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Sample records for meeren wellenenergie hat

  1. Hard-hat day

    CERN Multimedia

    2003-01-01

    CERN will be organizing a special information day on Friday, 27th June, designed to promote the wearing of hard hats and ensure that they are worn correctly. A new prevention campaign will also be launched.The event will take place in the hall of the Main Building from 11.30 a.m. to 2.00 p.m., when you will be able to come and try on various models of hard hat, including some of the very latest innovative designs, ask questions and pass on any comments and suggestions.

  2. DIY teleport hats - the consolation of technology

    DEFF Research Database (Denmark)

    Hansen, Lone Koefoed

    2009-01-01

    This instructable describes how to make a set of teleport hats. A teleport hat is a crocheted hat which doubles as a device with which you can teleport yourself to a person wearing the same type of hat in case you miss oneanother and want to be together without the hassle of driving, jetting or b...

  3. HAT-P-16b

    DEFF Research Database (Denmark)

    Buchhave, Lars A.; Bakos, G. A.; Hartman, J. D.

    2010-01-01

    We report the discovery of HAT-P-16b, a transiting extrasolar planet orbiting the V = 10.8 mag F8 dwarf GSC 2792-01700, with a period P = 2.775960 ± 0.000003 days, transit epoch Tc = 2455027.59293 ± 0.00031 (BJD10), and transit duration 0.1276 ± 0.0013 days. The host star has a mass of 1.22 ± 0...... theoretical models, we find that HAT-P-16b is consistent with a 1 Gyr H/He-dominated gas giant planet. HAT-P-16b resides in a sparsely populated region of the mass-radius diagram and has a non-zero eccentricity of e = 0.036 with a significance of 10s....

  4. HAT-P-25b

    DEFF Research Database (Denmark)

    Quinn, S.N.; Bakos, G. 'A; Hartman, J.

    2012-01-01

    We report the discovery of HAT-P-25b, a transiting extrasolar planet orbiting the V = 13.19 G5 dwarf star GSC 1788-01237, with a period P = 3.652836 +/- 0.000019 days, transit epoch Tc = 2455176.85173 +/- 0.00047 (BJD), and transit duration 0.1174 +/- 0.0017 days. The host star has mass of 1......(Jup), including those of core mass vs. metallicity, planet radius vs. equilibrium temperature, and orbital period vs. planet mass. We also note that HAT-P-25b orbits the faintest star found by HATNet to have a transiting planet to date, and is one of only a very few number of planets discovered from the ground...... these observations with recent theoretical models, we find that HAT-P-25b is consistent with a hydrogen-helium dominated gas giant planet with negligible core mass and age 3.2 +/- 2.3 Gyr. The properties of HAT-P-25b support several previously observed correlations for planets in the mass range 0.4

  5. HAT-P-38h

    DEFF Research Database (Denmark)

    Sato, Bun'ei; Hartman, Joel D.; Bakos, Gaspar Á.

    2012-01-01

    We report on the discovery of HAT-P-38b, a Saturn-mass exoplanet, transiting the V = 12.56 dwarf star GSC 2314-00559 on a P = 4.6404 d circular orbit. The host star is a 0.89 M-circle dot late G dwarf, with solar metallicity and a radius of 0.92 R-circle dot. The planetary companion has a mass of 0.......27 M-J and a radius of 0.82 R-J. HAT-P-38b is one of the planets the mass and radius of which have ever been discovered to be the closest to those of Saturn....

  6. ERRATUM: Work smart, wear your hard hat

    CERN Multimedia

    2003-01-01

    An error appeared in the article «Work smart, wear your hard hat» published in Weekly Bulletin 27/2003, page 5. The impact which pierced a hole in the hard hat worn by Gerd Fetchenhauer was the equivalent of a box weighing 5 kg and not 50 kg.

  7. HATS-39b, HATS-40b, HATS-41b, and HATS-42b: Three Inflated Hot Jupiters and a Super-Jupiter Transiting F Stars

    Science.gov (United States)

    Bento, J.; Hartman, J. D.; Bakos, G. Á.; Bhatti, W.; Csubry, Z.; Penev, K.; Bayliss, D.; de Val-Borro, M.; Zhou, G.; Brahm, R.; Espinoza, N.; Rabus, M.; Jordán, A.; Suc, V.; Ciceri, S.; Sarkis, P.; Henning, T.; Mancini, L.; Tinney, C. G.; Wright, D. J.; Durkan, S.; Tan, T. G.; Lázár, J.; Papp, I.; Sári, P.

    2018-03-01

    We report the discovery of four transiting hot Jupiters from the HATSouth survey: HATS-39, HATS-40, HATS-41 and HATS-42. These discoveries add to the growing number of transiting planets orbiting moderately bright (12.5 ≲ V ≲ 13.7) F dwarf stars on short (2-5 day) periods. The planets have similar radii, ranging from 1.33_{-0.20}^{+0.29} RJ for HATS-41b to 1.58_{-0.12}^{+0.16} RJ for HATS-40b. Their masses and bulk densities, however, span more than an order of magnitude. HATS-39b has a mass of 0.63 ± 0.13 MJ and an inflated radius of 1.57 ± 0.12 RJ making it a good target for future transmission spectroscopic studies. HATS-41b is a very massive 9.7 ± 1.6 MJ planet and one of only a few hot Jupiters found to date with a mass over 5 MJ. This planet orbits the highest metallicity star ([Fe/H]= 0.470 ± 0.010) known to host a transiting planet and is also likely on an eccentric orbit. The high mass, coupled with a relatively young age (1.34_{-0.51}^{+0.31} Gyr) for the host star, are factors that may explain why this planet's orbit has not yet circularised.

  8. "Work smart, wear your hard hat"

    CERN Multimedia

    2003-01-01

    Falling objects and collisions are frequent occurrences in work sites and hazardous areas. Hard hats can help prevent many types of accident and can even save lives. Just imagine an 800 g spanner falling from a 13 m high scaffold onto the head of someone standing below - a nightmare scenario! The impact to the head is equivalent to that of a 5 kg weight falling from 2 metres. That is just what happened to Gerd Fetchenhauer when he was working on the UA1 experiment. Fortunately, he was wearing a hard hat at the time. "That hat saved my life," he explains. "It punched a hole right through the hat and I was a bit dazed for a couple of hours but otherwise I was OK." Since that day, Gerd Fetchenhauer, now working on CMS, is never seen on a work site without his hard hat on. Work sites have proliferated at CERN with the construction of the LHC and its detectors, and the wearing of hard hats is compulsory (not to mention life-saving). In the underground caverns and experiment halls, where gantry cranes and other h...

  9. White or Black Hat? An Economic Analysis of Computer Hacking

    OpenAIRE

    Caitlin Brown

    2015-01-01

    Cyber attacks have increased sharply in recent years. This paper investigates the decision a profit-motivated hacker makes between working as a malicious hacker, called a black hat, and in cybersecurity as a white hat hacker. A key component of the model is the contest between white and black hats for some part of firm output that is vulnerable to attack. White and black hat earnings are increasing, nonlinear functions of the proportion of black hats. Multiple equilibria exist. Increasing the...

  10. Die ganzen zahlen hat Gott gemacht

    Indian Academy of Sciences (India)

    Home; Journals; Resonance – Journal of Science Education; Volume 6; Issue 9. Die ganzen zahlen hat Gott gemacht - Polynomials with Integer Values. B Sury. General Article Volume 6 Issue 9 September 2001 pp 46-60. Fulltext. Click here to view fulltext PDF. Permanent link:

  11. Association with the origin recognition complex suggests a novel role for histone acetyltransferase Hat1p/Hat2p

    Directory of Open Access Journals (Sweden)

    Greenblatt Jack F

    2007-09-01

    Full Text Available Abstract Background Histone modifications have been implicated in the regulation of transcription and, more recently, in DNA replication and repair. In yeast, a major conserved histone acetyltransferase, Hat1p, preferentially acetylates lysine residues 5 and 12 on histone H4. Results Here, we report that a nuclear sub-complex consisting of Hat1p and its partner Hat2p interacts physically and functionally with the origin recognition complex (ORC. While mutational inactivation of the histone acetyltransferase (HAT gene HAT1 alone does not compromise origin firing or initiation of DNA replication, a deletion in HAT1 (or HAT2 exacerbates the growth defects of conditional orc-ts mutants. Thus, the ORC-associated Hat1p-dependent histone acetyltransferase activity suggests a novel linkage between histone modification and DNA replication. Additional genetic and biochemical evidence points to the existence of partly overlapping histone H3 acetyltransferase activities in addition to Hat1p/Hat2p for proper DNA replication efficiency. Furthermore, we demonstrated a dynamic association of Hat1p with chromatin during S-phase that suggests a role of this enzyme at the replication fork. Conclusion We have found an intriguing new association of the Hat1p-dependent histone acetyltransferase in addition to its previously known role in nuclear chromatin assembly (Hat1p/Hat2p-Hif1p. The participation of a distinct Hat1p/Hat2p sub-complex suggests a linkage of histone H4 modification with ORC-dependent DNA replication.

  12. Quinoline Derivative MC1626, a Putative GCN5 Histone Acetyltransferase (HAT) Inhibitor, Exhibits HAT-Independent Activity against Toxoplasma gondii▿

    Science.gov (United States)

    Smith, Aaron T.; Livingston, Meredith R.; Mai, Antonello; Filetici, Patrizia; Queener, Sherry F.; Sullivan, William J.

    2007-01-01

    We report that quinoline derivative MC1626, first described as an inhibitor of the histone acetyltransferase (HAT) GCN5, is active against the protozoan parasite Toxoplasma gondii in vitro. However, MC1626 does not inhibit Toxoplasma GCN5 HATs or reduce HAT-mediated activity; rather, this quinoline may target the plastid organelle called the apicoplast. PMID:17178801

  13. Luftstaub über den Meeren

    DEFF Research Database (Denmark)

    Kacunko, Slavko; Kacunko, Sabine; Gorbushina, Ana

    2013-01-01

    Staub umgibt uns überall und alles wird auch irgendwann zu Staub - ob wir wollen oder nicht. Staub nicht nur zu bekämpfen, sondern zu untersuchen, bildet den Ausgangspunkt zahlreicher Forschungen in den Natur-, Ingenieur- und Kulturwissenschaften. Der vorliegende Band verbindet solche Beiträge au...

  14. HATS-43b, HATS-44b, HATS-45b, and HATS-46b: Four Short-period Transiting Giant Planets in the Neptune–Jupiter Mass Range

    Science.gov (United States)

    Brahm, R.; Hartman, J. D.; Jordán, A.; Bakos, G. Á.; Espinoza, N.; Rabus, M.; Bhatti, W.; Penev, K.; Sarkis, P.; Suc, V.; Csubry, Z.; Bayliss, D.; Bento, J.; Zhou, G.; Mancini, L.; Henning, T.; Ciceri, S.; de Val-Borro, M.; Shectman, S.; Crane, J. D.; Arriagada, P.; Butler, P.; Teske, J.; Thompson, I.; Osip, D.; Díaz, M.; Schmidt, B.; Lázár, J.; Papp, I.; Sári, P.

    2018-03-01

    We report the discovery of four short-period extrasolar planets transiting moderately bright stars from photometric measurements of the HATSouth network coupled to additional spectroscopic and photometric follow-up observations. While the planet masses range from 0.26 to 0.90 {M}{{J}}, the radii are all approximately a Jupiter radii, resulting in a wide range of bulk densities. The orbital period of the planets ranges from 2.7 days to 4.7 days, with HATS-43b having an orbit that appears to be marginally non-circular (e = 0.173 ± 0.089). HATS-44 is notable for having a high metallicity ([{Fe}/{{H}}] = 0.320 ± 0.071). The host stars spectral types range from late F to early K, and all of them are moderately bright (13.3 future detailed follow-up observations. HATS-43b and HATS-46b, with expected transmission signals of 2350 ppm and 1500 ppm, respectively, are particularly well suited targets for atmospheric characterization via transmission spectroscopy. The HATSouth network is operated by a collaboration consisting of Princeton University (PU), the Max Planck Institute für Astronomie (MPIA), the Australian National University (ANU), and the Pontificia Universidad Católica de Chile (PUC). The station at Las Campanas Observatory (LCO) of the Carnegie Institute is operated by PU in conjunction with PUC, the station at the High Energy Spectroscopic Survey (H.E.S.S.) site is operated in conjunction with MPIA, and the station at Siding Spring Observatory (SSO) is operated jointly with ANU. This paper includes data gathered with the MPG 2.2 m and ESO 3.6 m telescopes at the ESO Observatory in La Silla. This paper includes data gathered with the 6.5 meter Magellan Telescopes located at Las Campanas Observatory, Chile.

  15. VizieR Online Data Catalog: Spectroscopy and photometry for HAT-P-50--HAT-P-53 (Hartman+, 2015)

    Science.gov (United States)

    Hartman, J. D.; Bhatti, W.; Bakos, G. A.; Bieryla, A.; Kovacs, G.; Latham, D. W.; Csubry, Z.; de Val-Borro, M.; Penev, K.; Buchhave, L. A.; Torres, G.; Howard, A. W.; Marcy, G. W.; Johnson, J. A.; Isaacson, H.; Sato, B.; Boisse, I.; Falco, E.; Everett, M. E.; Szklenar, T.; Fulton, B. J.; Shporer, A.; Kovacs, T.; Hansen, T.; Beky, B.; Noyes, R. W.; Lazar, J.; Papp, I.; Sari, P.

    2016-04-01

    The HATNet network consists of six identical fully automated instruments, with four at Fred Lawrence Whipple Observatory (FLWO) in AZ, and two on the roof of the Submillimeter Array Hangar Building at Mauna Kea Observatory (MKO) in HI. The light-gathering elements of each instrument include an 11cm diameter telephoto lens, a Sloan r filter, and a 4K*4K front-side-illuminated CCD camera. Observations made in 2007 and early 2008 were carried out using a Cousins R filter. The instruments have a field of view of 10.6°*10.6° and a pixel scale of 9"/pixel at the center of an image. Additional time-series photometric measurements were obtained for all four of the systems using Keplercam on the FLWO 1.2m telescope. For HAT-P-50 we also obtained follow-up photometry with the CCD imager on the Byrne Observatory at Sedgwick (BOS) 0.8m telescope, located at Sedgwick Reserve in Santa Ynez Valley, CA, and operated by the Las Cumbres Observatory Global Telescope institute (LCOGT). HAT-P-50 was observed with HAT-10/G316 on 2008 Nov-2009 May, with HAT-5/G364 on 2009 May, with HAT-9/G364 on 2008 Dec-2009 May, with BOS on 2012 Feb 15, on 2012 Feb 21 and on 2012 Apr 08, and with Keplercam on 2012 Feb 18, on 2012 Nov 28, on 2012 Dec 23, on 2013 Jan 14, and on 2013 Jan 17. HAT-P-51 was observed with HAT-6/G164 on 2007 Sep-2008 Feb, with HAT-9/G164 on 2007 Sep-2008 Feb, with HAT-10/G165 on 2010 Sep-2011 Jan, with HAT-5/G165 on 2010 Nov-2011 Feb, with HAT-8/G165 on 2010 Nov-2011 Feb, with HAT-6/G209 on 2010 Nov-2011 Feb, with HAT-9/G209 on 2010 Nov-2011 Feb, with HAT-7/G210 on 2010 Nov-2011 Jan, and with Keplercam on 2011 Oct 21, on 2012 Jan 05, on 2012 Oct 05, on 2012 Oct 26, and on 2012 Nov 12. HAT-P-52 was observed with HAT-5/G212 on 2010 Sep-Nov, with HAT-8/G212 on 2010 Aug-Nov, and with Keplercam on 2010 Dec 23, on 2011 Sep 05, on 2011 Sep 27, on 2011 Nov 21, and on 2012 Jan 07. HAT-P-53 was observed with HAT-6/G164 on 2007 Sep-2008 Feb, with HAT-9/G164 on 2007 Sep-2008 Feb, with

  16. Engineering assessment of inactive uranium mill tailings: Mexican Hat site, Mexican Hat, Utah. Summary

    International Nuclear Information System (INIS)

    1981-09-01

    Ford, Bacon and Davis Utah Inc. has reevaluated the Mexican Hat site in order to revise the March 1977 engineering assessment of the problems resulting from the existence of radioactive uranium mill tailings at Mexican Hat, Utah. This engineering assessment has included the preparation of topographic maps, the performance of core drillings and radiometric measurements sufficient to determine areas and volumes of tailings and radiation exposures of individuals and nearby populations, the investigations of site hydrology and meteorology, and the investigations of site hydrology and meteorology, and the evaluation and costing of alternative corrective actions. Radon gas released from the 2.2 million tons of tailings at the Mexican Hat site constitutes the most significant environmental impact, although windblown tailings and external gamma radiation also are factors. The four alternative actions presented in this engineering assessment range from millsite decontamination with the addition of 3 m of stabilization cover material to removal of the tailings to remote disposal sites and decontamination of the tailings site. Cost estimates for the four options range from about $15,200,000 for stabilization in place, to about $45,500,000 for disposal at a distance of about 16 mi. Three principal alternatives for the reprocessing of the Mexican Hat tailings were examined: (a) heap leaching; treatment at an existing mill; and reprocessing at a new conventional mill constructed for tailings reprocessing. The cost of the uranium recovered would be about $115/lb of U 3 O 8 whether by heap leach or conventional plant processes. The spot market price for uranium was $25/lb early in 1981. Reprocessing the Mexican Hat tailings for uranium recovery is not economically attractive under present conditions

  17. The "Burgundian" hat from Herjolfsnes, Greenland: new discoveries, new dates

    DEFF Research Database (Denmark)

    Smith, Michèle Hayeur; Arneborg, Jette; Smith, Kevin

    2016-01-01

    In 1921, during Poul Nørlund’s excavation at the Norse farm Herjolfsnes, Greenland, a tall hat was recovered from the burial grounds surrounding the farm’s church, where a substantial collection of medieval garments had been recovered. This unusual hat came to symbolize not only the end of the Gr...

  18. Home telemanagement for patients with ulcerative colitis (UC HAT).

    Science.gov (United States)

    Cross, Raymond K; Cheevers, Nadia; Finkelstein, Joseph

    2009-11-01

    Effective therapies exist to treat ulcerative colitis (UC); nonadherence, inadequate monitoring, and side-effects result in suboptimal outcomes. Novel methods for monitoring are needed. Our objectives were to assess acceptance of home automated telemanagement in ulcerative colitis (UC HAT). The UC HAT system consists of a laptop connected to a scale, a decision support server, and a web-based clinician portal. The UC HAT system facilitates self-care in UC patients by monitoring patient symptoms, side-effects, and adherence, and helping patients in following their individualized treatment plans. Ten adult patients with UC were trained to use UC HAT. Attitudinal surveys and qualitative interviews were performed. The results showed that all patients reported that use of the computer was not complicated. 90% reported that the symptom diary and side-effect questions were not difficult. All patients reported that the training was adequate and 70% reported that testing took little time. Seventy percent would feel safer using the system, and 90% would agree to use UC HAT in the future. Patients felt UC HAT would keep the patient and provider up to date on changes in symptoms. Self-testing appeared to make patients accountable for managing the disease. It was discussed that improved monitoring is needed for UC. Patients with UC can be easily trained to use HAT, and patient acceptance of the UC HAT system is high. Home automated telemanagement has potential to improve clinical outcomes and patient satisfaction in UC.

  19. Long-term surveillance plan for the Mexican Hat disposal site, Mexican Hat, Utah

    International Nuclear Information System (INIS)

    1996-01-01

    This plan describes the long-term surveillance activities for the Uranium Mill Tailings Remedial Action (UMTRA) Project disposal site at Mexican Hat, Utah. The US Department of Energy (DOE) will carry out these activities to ensure that the disposal site continues to function as designed. This long-term surveillance plan (LTSP) was prepared as a requirement for acceptance under the US Nuclear Regulatory Commission (NRC) general license for custody and long-term care of residual radioactive material (RRM). This LTSPC documents the land ownership interests and details how the long-term care of the disposal site will be accomplished

  20. Bi-Directional Communication: A Critical Component of HAT

    Science.gov (United States)

    Shively, Robert J.

    2016-01-01

    Known problems with automation include lack of mode awareness, automation brittleness, and risk of miscalibrated trust. Human-Autonomy Teaming (HAT) is essential for improving these problems. This presentation outlines critical components for Human-Autonomy Teaming.

  1. On the placement of a number of strings in a cllection of hats ...

    African Journals Online (AJOL)

    The following problem is considered in this paper: Suppose k strings of unit length are to be distributed amongst x hats. If cuts in the strings are allowed, how should the string (parts) be distributed amongst the hats so that, if the shortest string is removed from each hat, the remaining (combined) string length in the hat with ...

  2. Environmental assessment of remedial action at the Mexican Hat uranium mill tailings site, Mexican Hat, Utah

    International Nuclear Information System (INIS)

    1987-10-01

    This document assesses the environmental impacts of the proposed remedial action at the Mexican Hat uranium mill tailings site located on the Navajo Reservation in southern Utah. The site covers 235 acres and contains 69 acres of tailings and several of the original mill structures. Remedial action must be performed in accordance with standards and with the concurrence of the US Nuclear Regulatory Commission and the Navajo Nation. The proposed action is to stabilize the tailings within the present tailings site by consolidating the tailings and associated contaminated soils into a recontoured pile. A radon barrier of compacted earth would be constructed over the pile, and various erosion control measures would be taken to assure the long-term stability of the pile. The no action alternative is also assessed in this document. 240 refs., 12 figs., 20 tabs

  3. Long-term surveillance plan for the Mexican Hat Disposal Site, Mexican Hat, Utah

    International Nuclear Information System (INIS)

    1996-02-01

    This plan describes the long-term surveillance activities for the Uranium Mill Tailings Remedial Action (UMTRA) Project disposal site at Mexican Hat, Utah. The U.S. Department of Energy (DOE) will carry out these activities to ensure that the disposal site continues to function as designed. This long-term surveillance plan (LTSP) was prepared as a requirement for acceptance under the U.S. Nuclear Regulatory Commission (NRC) general license for custody and long-term care of residual radioactive material (RRM). This LTSP (based on the DOE's Guidance for Implementing the UMTRA Project Long-term Surveillance Program), documents the land ownership interests and details how the long-term care of the disposal site will be accomplished

  4. VizieR Online Data Catalog: Photometry for HATS-31 through HATS-35 (de Val-Borro+, 2016)

    Science.gov (United States)

    de Val-Borro, M.; Bakos, G. A.; Brahm, R.; Hartman, J. D.; Espinoza, N.; Penev, K.; Ciceri, S.; Jordan, A.; Bhatti, W.; Csubry, Z.; Bayliss, D.; Bento, J.; Zhou, G.; Rabus, M.; Mancini, L.; Henning, T.; Schmidt, B.; Tan, T. G.; Tinney, C. G.; Wright, D. J.; Kedziora-Chudczer, L.; Bailey, J.; Suc, V.; Durkan, S.; Lazar, J.; Papp, I.; Sari, P.

    2017-05-01

    The HATSouth survey is a global network of homogeneous, completely automated wide-field telescopes located at three sites in the Southern Hemisphere: HS-1 and -2 are located at Las Campanas Observatory (LCO) in Chile, HS-3 and -4 are located at the High Energy Stereoscopic Survey (H.E.S.S.) site in Namibia, and HS-5 and -6 are located at Siding Spring Observatory (SSO) in Australia. Observations are performed using a Sloan-r filter with four-minute exposures. The HATSouth network was commissioned in 2009 and since then has proved to be a robust system for the monitoring of time-variable phenomena. Each HATSouth unit consists of four Takahashi E180 astrographs with an aperture of 18cm and an f/2.8 focal ratio on a common mount, equipped with Apogee 4096*4096 U16M ALTA cameras. HATS-31 was observed with the HS-1.4/G565 on 2012 Dec-2013 Jun, with the HS-3.4/G565 on 2012 Dec-2013 Jul, and with the HS-5.4/G565 on 2012 Dec-2013 Jul. HATS-32 was observed with the HS-2.3/G586 on 2010 Aug-2011 Nov, with the HS-4.3/G586 on 2010 Aug-2011 Nov, and with the HS-6.3/G586 on 2010 Aug-2011 Nov. HATS-33 was observed with the HS-1.4/G747 on 2013 Mar-2013 Oct, with the HS-2.4/G747 on 2013 Sep-2013 Oct, with the HS-3.4/G747 on 2013 Apr-2013 Nov, with the HS-4.4/G747 on 2013 Sep-2013 Nov, with the HS-5.4/G747 on 2013 Mar-2013 Nov, and with the HS-6.4/G747 on 2013 Sep-2013 Nov. HATS-34 was observed with the HS-2.4/G754 on 2012 Sep-2012 Dec, with the HS-4.4/G754 on 2012 Sep-2013 Jan, and with the HS-6.4/G754 on 2012 Sep-2012 Dec. HATS-35 was observed with the HS-2.4/G778 on 2011 May-2012 Nov, with the HS-4.4/G778 on 2011 Jul-2012 Nov, with the HS-6.4/G778 on 2011 Apr-2012 Oct. The egress of HATS-31b was observed on 2015 February 28 and 2015 April 02 with the Las Cumbres Observatory Global Telescope (LCOGT) 1m+Cerro Tololo Inter-American Observatory (CTIO) telescope network and the Swope 1m telescopes, respectively. Additionally, an almost full transit of HATS-31b was observed with LCOGT 1

  5. Collaborative care: Using six thinking hats for decision making.

    Science.gov (United States)

    Cioffi, Jane Marie

    2017-12-01

    To apply six thinking hats technique for decision making in collaborative care. In collaborative partnerships, effective communications need to occur in patient, family, and health care professional meetings. The effectiveness of these meetings depends on the engagement of participants and the quality of the meeting process. The use of six thinking hats technique to engage all participants in effective dialogue is proposed. Discussion paper. Electronic databases, CINAHL, Pub Med, and Science Direct, were searched for years 1990 to 2017. Using six thinking hats technique in patient family meetings nurses can guide a process of dialogue that focuses decision making to build equal care partnerships inclusive of all participants. Nurses will need to develop the skills for using six thinking hats technique and provide support to all participants during the meeting process. Collaborative decision making can be augmented by six thinking hat technique to provide patients, families, and health professionals with opportunities to make informed decisions about care that considers key issues for all involved. Nurses who are most often advocates for patients and their families are in a unique position to lead this initiative in meetings as they network with all health professionals. © 2017 John Wiley & Sons Australia, Ltd.

  6. RSRM top hat cover simulator lightning test, volume 1

    Science.gov (United States)

    1990-01-01

    The test sequence was to measure electric and magnetic fields induced inside a redesigned solid rocket motor case when a simulated lightning discharge strikes an exposed top hat cover simulator. The test sequence was conducted between 21 June and 17 July 1990. Thirty-six high rate-of-rise Marx generator discharges and eight high current bank discharges were injected onto three different test article configurations. Attach points included three locations on the top hat cover simulator and two locations on the mounting bolts. Top hat cover simulator and mounting bolt damage and grain cover damage was observed. Overall electric field levels were well below 30 kilowatts/meter. Electric field levels ranged from 184.7 to 345.9 volts/meter and magnetic field levels were calculated from 6.921 to 39.73 amperes/meter. It is recommended that the redesigned solid rocket motor top hat cover be used in Configuration 1 or Configuration 2 as an interim lightning protection device until a lightweight cover can be designed.

  7. Effectiveness Of Six Thinking Hats Training In Improving The ...

    African Journals Online (AJOL)

    This study investigated the effectiveness of Six Thinking Hats Training in improving the psychological well- being of prisoners. The study consisted of 24 convicted prisoners whose ages ranged from 19-60 years with a mean of 22.50 years. A 2x2 experimental group design was adopted, and subjects were randomly ...

  8. Dr. Edward de Bono's Six Thinking Hats and Numeracy

    Science.gov (United States)

    Paterson, Anne

    2006-01-01

    In education, the term "metacognition" describes thinking about thinking. Within mathematics, the term "metacomputation" describes thinking about computational methods and tools. This article shows how Dr. Edward de Bono's Six Thinking Hats can be used to demonstrate metacognition and metacomputation in the primary classroom. The article suggests…

  9. Broad-band spectrophotometry of HAT-P-32 b

    DEFF Research Database (Denmark)

    Mallonn, M.; Bernt, I.; Herrero, E.

    2016-01-01

    Multicolour broad-band transit observations offer the opportunity to characterize the atmosphere of an extrasolar planet with small- to medium-sized telescopes. One of the most favourable targets is the hot Jupiter HAT-P-32 b. We combined 21 new transit observations of this planet with 36 previou...

  10. The long duration flight of the TopHat experiment

    DEFF Research Database (Denmark)

    Silverberg, R. F.; Aguirre, J.; Bezaire, J.

    2003-01-01

    The TopHat instrument was designed to operate on the top of a high altitude balloon. From this location, the experiment could efficiently observe using a clean beam with extremely low contamination from the far side lobes of the instrument beam. The experiment was designed to scan a large portion...

  11. FACTORS & ELEMENTAL ANALYSIS OF SIX THINKING HATS TECHNIQUE USING ABCD FRAMEWORK

    OpenAIRE

    Dr. P. S. Aithal; V. T. Shailashree; Dr. P. M. Suresh Kumar

    2017-01-01

    De Bono's Six Thinking Hats technique suggests different types of thinking corresponding to six thinking roles for the analyst, associated with hats of six different colors. The technique correlates different thinking styles used in a systematic problem solving procedure with different coloured hats. Alternately, by conceptualizing each type of hat, the person focuses on the style of thinking associated with each colour so that the problem can be analysed from different angles and frame of re...

  12. Near UV Observation of HAT-P-16b

    Science.gov (United States)

    Pearson, Kyle; Turner, J.

    2013-06-01

    We observed the primary transit of the hot Jupiter HAT-P-16b in the near-UV photometric band on December 29, 2012 in an attempt to detect its magnetic field. Vidotto, Jardine & Helling (2011) postulate that the magnetic field of HAT-P-16b can be constrained if its near-UV light curve shows an early ingress compared to its optical light curve, while its egress remains unswayed. Predicted magnetic fields of Jupiter-like planets should range between 8 G (Reiners & Christensen 2010) and 40 G (Sanchez-Lavega 2004). However, we derived an upper limit of the magnetic field strength of HAT-P-16b to range between 0.0082 and 0.82 G (for a 1--100 G magnetic field strength range for the host star, HAT-P-16). Using these magnetic field values and an assumed B* of 100 G, the Vidotto, Jardine & Helling (2011) method predicts a timing difference of 19--38 mins. We did not detect an early ingress in our night of observing when using a cadence of 45 seconds and an average photometric precision of 2.25 mmag. We present the first near-UV light curve of HAT-P-16b and find a near-UV planetary radius of 1.242+-0.056 (R_Jup) which is consistent with its near-IR radius of R=1.289+-0.066 (R_Jup) (Buchhave 2010). We developed an automated reduction pipeline and a modeling package to process our data. The modeling package utilizes the Levenberg-Marquardt minimization algorithm to find a least-squares best fit and a differential evolution Markov Chain Monte Carlo to find the best fit to the light curve, and uses both the residual permutation (rosary bead) method and time-averaging method (Pont 2006) to constrain the red noise in both fitting methods.

  13. Oxylipin-coated hat-shaped ascospores of Ascoidea corymbosa.

    Science.gov (United States)

    Ncango, Desmond M; Pohl, Carolina H; Sebolai, Olihile M; Botes, Piet J; Strauss, Catharina J; Joseph, Manjusha; Van Wyk, Pieter W J; Nigam, Santosh; Kock, Johan L F

    2006-11-01

    We previously implicated 3-hydroxy oxylipins and ascospore structure in ascospore release from enclosed asci. Using confocal laser scanning microscopy on cells stained with fluorescein-coupled, 3-hydroxy oxylipin-specific antibodies, we found that oxylipins are specifically associated with ascospores and not the vegetative cells or ascus wall of Ascoidea corymbosa. Using gas chromatography--mass spectrometry the oxylipin 3-hydroxy 17:0 could be identified. Here, we visualize for the first time the forced release of oxylipin-coated, hat-shaped ascospores from terminally torn asci, probably through turgor pressure. We suggest that oxylipin-coated, razor-sharp, hat-shaped ascospore brims may play a role in rupturing the ascus to affect release.

  14. Analysis Of Kepler Observations Of HAT-P-7 b

    Science.gov (United States)

    Jackson, Brian; Deming, D.

    2011-09-01

    HAT-P-7 b is among the hottest hot Jupiters ever discovered. Its orbital distance of about 4 stellar radii from an F star suggests the planet has a dayside temperature in excess of 2700 K. Moreover, HAT-P-7 b exerts tremendous tidal influence on its host star, significantly distorting the star's equilibrium shape. Prompted in part by these expectations, the Kepler mission observed the HAT-P-7 system in its short-cadence mode (i.e. 60 second integration times) from May 2009 till December 2010. Early analyses of a subset of these data have revealed the unique phenomena exhibited by this system. Borucki et al. (2009) analyzed the first ten days of observations (quarter 0) and identified atmospheric emission from the planet, suggesting a dayside temperature of 2650 K and little day-to-nightside redistribution of stellar heating. Welsh et al. (2010) followed with an analysis of 34 days of observations (quarter 1) and found an increase in flux from the system as the planet passed through quadrature. These oscillations are consistent with variations in the host star's projected surface area resulting from its tidal distortion (ellipsoidal variations). Since those analyses, another 90 days (quarter 2) of Kepler data have been made public, nearly tripling the number of planetary transits observed. This increase in the number of transits allows more complete removal of other systematic variations, facilitating a search for planetary variability. In this presentation, we will discuss our analysis of the publicly available Kepler transit data of HAT-P-7 b. We will present improved constraints on transit parameters and the ellipsoidal variations exhibited by the host star. We will also discuss our search for changes from one orbit to the next in the planet's phase curve, indicative of meteorological variability. Jackson was funded through the NASA Postdoctoral Program (NPP).

  15. VizieR Online Data Catalog: iz follow-up photometry of HAT-P-65 and HAT-P-66 (Hartman+, 2016)

    Science.gov (United States)

    Hartman, J. D.; Bakos, G. A.; Bhatti, W.; Penev, K.; Bieryla, A.; Latham, D. W.; Kovacs, G.; Torres, G.; Csubry, Z.; de Val-Borro, M.; Buchhave, L.; Kovacs, T.; Quinn, S.; Howard, A. W.; Isaacson, H.; Fulton, B. J.; Everett, M. E.; Esquerdo, G.; Beky, B.; Szklenar, T.; Falco, E.; Santerne, A.; Boisse, I.; Hebrard, G.; Burrows, A.; Lazar, J.; Papp, I.; Sari, P.

    2017-05-01

    Both HAT-P-65 and Both HAT-P-66 were selected as candidate transiting planet systems based on Sloan r-band photometric time series observations carried out with the HATNet telescope network. HATNet consists of six 11cm aperture telephoto lenses, each coupled to an APOGEE front-side-illuminated CCD camera, and each placed on a fully automated telescope mount. Four of the instruments are located at Fred Lawrence Whipple Observatory (FLWO) in Arizona, USA, while two are located on the roof of the Submillimeter Array hangar building at Mauna Kea Observatory (MKO) on the island of Hawaii, USA. Each instrument observes a 10.6°*10.6° field of view. We conducted follow-up photometric time series observations of each object using KeplerCam on the 1.2m telescope at FLWO. HAT-P-65 was observed on 2009 Sep-Dec with a r-band filter using the HAT-6/G342 (located at FLWO) and the HAT-8/G342 (located on the roof of the Smithsonian Astrophysical Observatory Submillimeter Array hangar building at Mauna Kea Observatory in Hawaii), and on 2011 Jun 10 (i filter), 2011 Jun 26 (i filter), 2011 Jul 14 (i filter), 2011 Sep 20 (i filter), 2013 Sep 16 (z filter), 2013 Sep 29 (i filter), and 2013 Oct 04 (i filter) using the FLWO 1.2m/KeplerCam. HAT-P-66 was observed on 2011 Feb-2012 Mar using the HAT-10/G101 (located at FLWO) with a r-band filter, using the HAT-6/G101 (located at FLWO) with a r-band filter, and using the HAT-7/G101 (located at FLWO) with a r-band filter, on 2011 Feb-2012 Apr using the HAT-5/G101 (located at FLWO) with a r-band filter, on 2011 May-2012 Jun using the HAT-8/G101 (located on the roof of the Smithsonian Astrophysical Observatory Submillimeter Array hangar building at Mauna Kea Observatory in Hawaii) with a r-band filter, on 2011 Oct-2012 Jan using the HAT-9/G101 (located at FLWO) with a r-band filter, and on 2015 Apr 29 (i filter), 2015 Nov 26 (z filter), 2015 Dec 08 (i filter) using the FLWO 1.2m/KeplerCam. Spectroscopic observations of both HAT-P-65 and HAT

  16. UMTRA project water sampling and analysis plan, Mexican Hat, Utah

    International Nuclear Information System (INIS)

    1994-04-01

    The Mexican Hat, Utah, Uranium Mill Tailings Remedial Action (UMTRA) Project site is a former uranium mill that is undergoing surface remediation in the form of on-site tailings stabilization. Contaminated surface materials from the Monument Valley, Arizona, UMTRA Project site have been transported to the Mexican Hat site and are being consolidated with the Mexican Hat tailings. The scheduled completion of the tailings disposal cell is August 1995. Water is found in two geologic units at the site: the Halgaito Shale Formation and the Honaker Trail Formation. The tailings rest on the Halgaito Shale, and water contained in that unit is a result of milling activities and, to a lesser extent, water released from the tailings from compaction during remedial action construction of the disposal cell. Water in the Halgaito Shale flows through fractures and discharges at seeps along nearby arroyos. Flow from the seeps will diminish as water drains from the unit. Ground water in the lower unit, the Honaker Trail Formation, is protected from contamination by an upward hydraulic gradient. There are no nearby water supply wells because of widespread poor background ground water quality and quantity, and the San Juan River shows no impacts from the site. This water sampling and analysis plan (WSAP) recommends sampling six seeps and one upgradient monitor well compared in the Honaker Trail Formation. Samples will be taken in April 1994 (representative of high group water levels) and September 1994 (representative of low ground water levels). Analyses will be performed on filtered samples for plume indicator parameters

  17. USING SIX THINKING HATS AS A TOOL FOR LATERAL THINKING IN ORGANIZATIONAL PROBLEM SOLVING

    OpenAIRE

    Dr. P. S. Aithal; Dr. P. M. Suresh Kumar

    2016-01-01

    Six thinking hats is recently introduced technique which outlines different thinking styles required by an individual while analysing a given problem in an effective way. The technique correlates different thinking styles used in a systematic problem-solving procedure with different coloured hats. Alternately, by conceptualizing each type of hat, the person focuses on the style of thinking associated with each colour so that the problem can be analysed from different angles and frame of refer...

  18. Randomized, controlled trial of home telemanagement in patients with ulcerative colitis (UC HAT).

    Science.gov (United States)

    Cross, Raymond K; Cheevers, Nadia; Rustgi, Ankur; Langenberg, Patricia; Finkelstein, Joseph

    2012-06-01

    Outcomes are suboptimal in ulcerative colitis (UC). Telemedicine for UC is feasible and improves outcomes. Our goals were to evaluate a home telemanagement system for UC (UC HAT) on disease activity, quality of life (QoL), and adherence compared to best available care (BAC) in a randomized, controlled trial. Adults with UC were randomly assigned to receive UC HAT or BAC for 12 months. UC HAT recruits answered questions regarding disease activity, adherence, side effects, and measured their weight weekly. An educational curriculum was delivered after each session. Alerts and action plans were generated based on the results. BAC underwent routine follow-up, received written action plans, and were given educational fact sheets. Seo Index scores, Inflammatory Bowel Disease Questionnaire (IBDQ) scores, and adherence rates were compared between UC HAT and BAC at 1 year. Twenty-five patients were randomized to UC HAT and 22 to BAC. After 12 months, 11 withdrew in UC HAT compared to 5 in BAC. Disease activity, QoL, and adherence were not different between groups at any timepoint postbaseline. Adjusted analyses of trial completers using all available data demonstrated decreased Seo Index (11.9 in UC HAT (P = 0.08) versus 1.2 in BAC (P = 0.84) and increased IBDQ scores (12.5 in UC HAT (P = 0.04) versus to -3.8 in BAC (P = 0.47) from baseline in UC HAT compared to BAC. UC HAT did not improve disease activity, QoL, or adherence compared to BAC after 1 year. After adjustment for baseline disease knowledge, UC HAT trial completers experienced significant gains in disease-specific QoL from baseline compared to BAC trial completers. Our results suggest a potential benefit of UC HAT. Further research is indicated to determine if telemedicine improves outcomes in patients with IBD. Copyright © 2011 Crohn's & Colitis Foundation of America, Inc.

  19. Eagle Hats Mini-Technology Integration Experiment (TIE)

    Science.gov (United States)

    2005-07-01

    code base more portable to other Lisp dialects such as OpenMCL, LispWorks, Franz Lisp, and SBCL. The Hats mini-TIE Community Mechanics We have...is taken from stories in newspaper texts and is encoded in in the standard GB-scheme. Franz Kafka’s The Castle in the original German comprised the...the Chinese corpus, 32% of the Roma-ji corpus, 17% of the Orwell corpus, and 10% of the Kafka corpus, so it is not surprising that the algorithm

  20. Validation of buoyancy driven spectral tensor model using HATS data

    DEFF Research Database (Denmark)

    Chougule, A.; Mann, Jakob; Kelly, Mark C.

    2016-01-01

    We present a homogeneous spectral tensor model for wind velocity and temperature fluctuations, driven by mean vertical shear and mean temperature gradient. Results from the model, including one-dimensional velocity and temperature spectra and the associated co-spectra, are shown in this paper....... The model also reproduces two-point statistics, such as coherence and phases, via cross-spectra between two points separated in space. Model results are compared with observations from the Horizontal Array Turbulence Study (HATS) field program (Horst et al. 2004). The spectral velocity tensor in the model...

  1. Heroin-assisted treatment (HAT) a decade later: a brief update on science and politics

    NARCIS (Netherlands)

    Fischer, Benedikt; Oviedo-Joekes, Eugenia; Blanken, Peter; Haasen, Christian; Rehm, Jürgen; Schechter, Martin T.; Strang, John; van den Brink, Wim

    2007-01-01

    Since the initial Swiss heroin-assisted treatment (HAT) study conducted in the mid-1990s, several other jurisdictions in Europe and North America have implemented HAT trials. All of these studies embrace the same goal-investigating the utility of medical heroin prescribing for problematic opioid

  2. Giant Paperclip Necklaces, Soup-Can Rings and Cherry-Pie Hats

    Science.gov (United States)

    Winters, Laurel A.

    2011-01-01

    In this article, the author describes an art project inspired by the wearable sculpture art created by artist Marjorie Schick. Students used wallpaper paste and newspapers to create papier-mache for a mountain hat, a cherry-pie mask/hat, a "dress" shoe and a Cubistic mask. Cardboard was used in many of these things, in addition to being used as…

  3. Home Automated Telemanagement (HAT System to Facilitate Self-Care of Patients with Chronic Diseases

    Directory of Open Access Journals (Sweden)

    Joseph Finkelstein

    2003-06-01

    Full Text Available Successful patient self-management requires a multidisciplinary approach that includes regular patient assessment, disease-specific education, control of medication adherence, implementation of health behavior change models and social support. Existing systems for computer-assisted disease management do not provide this multidisciplinary patient support and do not address treatment compliance issues. We developed the Home Automated Telemanagement (HAT system for patients with different chronic health conditions to facilitate their self-care. The HAT system consists of a home unit, HAT server, and clinician units. Patients at home use a palmtop or a laptop connected with a disease monitor on a regular basis. Each HAT session consists of self-testing, feedback, and educational components. The self-reported symptom data and objective results obtained from disease-specific sensors are automatically sent from patient homes to the HAT server in the hospital. Any web-enabled device can serve as a clinician unit to review patient results. The HAT system monitors self-testing results and patient compliance. The HAT system has been implemented and tested in patients receiving anticoagulation therapy, patients with asthma, COPD and other health conditions. Evaluation results indicated high level of acceptance of the HAT system by the patients and that the system has a positive impact on main clinical outcomes and patient satisfaction with medical care.

  4. Incidence of Hospital Acquired Thrombosis (HAT) in a Tertiary Care Hospital.

    LENUS (Irish Health Repository)

    Khan, MI

    2017-04-01

    Venous thromboembolism (VTE) is a major cause of preventable morbidity and mortality in hospitalized patients. In spite of guidelines, VTE prophylaxis continues to be underutilised, and hospital acquired thrombosis (HAT) continues to be a problem. This study was conducted to estimate the incidence of HAT in a tertiary referral centre and to examine whether VTE risk assessment and thromboprophylaxis (TP) were implemented. Patients 18 years and above, with a radiologically-confirmed acute VTE during the study period of 15 weeks were included. Acute VTE was diagnosed in 100 patients and HAT was diagnosed in 48. There were 12,024 admissions over the study period, therefore the incidence of HAT was 0.4%. TP was prescribed in only 35% of patients, and 65% did not receive any or appropriate TP. Hospitals without active implementation of a formal risk assessment tool and TP policy are likely to continue to have increased incidence of HAT.

  5. The man who mistook his wife for a hat

    CERN Document Server

    Sacks, Oliver

    2011-01-01

    Oliver Sacks’s The Man Who Mistook His Wife for a Hat tells the stories of individuals afflicted with fantastic perceptual and intellectual aberrations: patients who have lost their memories and with them the greater part of their pasts; who are no longer able to recognize people and common objects; who are stricken with violent tics and grimaces or who shout involuntary obscenities; whose limbs have become alien; who have been dismissed as retarded yet are gifted with uncanny artistic or mathematical talents. If inconceivably strange, these brilliant tales remain, in Dr. Sacks’s splendid and sympathetic telling, deeply human. They are studies of life struggling against incredible adversity, and they enable us to enter the world of the neurologically impaired, to imagine with our hearts what it must be to live and feel as they do. A great healer, Sacks never loses sight of medicine’s ultimate responsibility: “the suffering, afflicted, fighting human subject.”

  6. Monitoring of BTX by passive sampling in Hat Yai

    Directory of Open Access Journals (Sweden)

    Proespichaya Kanatharana

    2004-02-01

    Full Text Available Laboratory-built passive samplers were used for monitoring of trace benzene, toluene and xylene (BTX in Hat Yai from 28 July to 12 August, 2003. Sampler bottles contained activated Tenax TA 60/80 meshand a lab-built thermal well were developed and evaluated for the sampling and analysis of BTX. The sampling was carried out for two weeks before the passive samplers were thermally desorbed, trapped ina sampling loop by a laboratory built purge and trap system and analysed by gas chromatography (GC equipped with a flame ionization detector. After optimization and calibration, the developed method showed high selectivity, a good sensitivity with detection limits for BTX of 0.8, 1.1 and 13.0 µg/m3 respectively and an acceptable precision. Ambient BTX measurements were conducted at many monitoring site i.e. hot spots (high exposure, residential areas/work places (common exposure and park (low exposure. The concentration at hot spots range from 3.2 to 5.4 µg/m3 for benzene, 38.0 to 80.3 µg/m3 for toluene and 29.7 to 66.7 µg/m3 for xylene.The low BTX were found at the city periphery (Tesco-Lotus billboard sampling stations, roof level and in Hat Yai Municipal Park but no absolute background concentration could be defined. The monitoring results showed that at higher level from the street surface, the level of BTX tended to decrease and the BTX pollution built up along a street canyon (Sanehanuson Road according to the wind direction. The highest BTX were found at the underground parking, 23.5 725.1 and 267.9 µg/m3 respectively where both WHO guideline for Benzene (16.3 µg/m3 and Toluene (260 µg/m3 were exceeded.

  7. Midterm evaluation of hemodynamics of the Top Hat supraannular aortic valve

    DEFF Research Database (Denmark)

    Aagaard, Jan; Nissen, Henrik; Geha, Alexander S

    2010-01-01

    measurements were compared in 38 patients with aortic valve stenosis. Hemodynamic data were comparable to those of other studies, but the Top Hat prosthesis implanted was significantly larger (by a mean of 3.29 mm) than the valve size indicated using an intraannular valve sizer in 48 patients. Mean effective...... studies of Top Hat or CarboMedics intraannular valves. Echocardiography was performed 6-48 months after surgery with Top Hat sizes 21-27. Parameters evaluated included mean gradient, peak gradient, effective orifice area, and effective orifice area index. Preoperative and postoperative echocardiographic...

  8. Maximizing prosthetic valve size with the Top Hat supra-annular aortic valve

    DEFF Research Database (Denmark)

    Aagaard, Jan; Geha, Alexander S.

    2007-01-01

    BACKGROUND AND AIM OF THE STUDY: The CarboMedics Top Hat supra-annular aortic valve allows a one-size (and often two-size) increase over the standard intra-annular valve. This advantage should minimize the risk of patient-prosthesis mismatch, where the effective prosthetic valve orifice area....... This study evaluates the authors' clinical experience with Top Hat supra-annular aortic valve size selection, and the technical aspects of implantation. METHODS: Between January 1999 and October 2005, a total of 251 consecutive patients underwent 252 aortic valve replacements with Top Hat supra...... required unplanned coronary bypass, and 30-day mortality was 2.0% (5/251), indicating a good safety profile for the valves implanted in this series. CONCLUSION: The general distribution of implant sizes in the US indicates that cardiac surgeons may be under-sizing the Top Hat supra-annular aortic valve...

  9. Heroin-assisted Treatment (HAT) a Decade Later: A Brief Update on Science and Politics

    Science.gov (United States)

    Oviedo-Joekes, Eugenia; Blanken, Peter; Haasen, Christian; Rehm, Jürgen; Schechter, Martin T.; Strang, John; van den Brink, Wim

    2007-01-01

    Since the initial Swiss heroin-assisted treatment (HAT) study conducted in the mid-1990s, several other jurisdictions in Europe and North America have implemented HAT trials. All of these studies embrace the same goal—investigating the utility of medical heroin prescribing for problematic opioid users—yet are distinct in various key details. This paper briefly reviews (initiated or completed) studies and their main parameters, including primary research objectives, design, target populations, outcome measures, current status and—where available—key results. We conclude this overview with some final observations on a decade of intensive HAT research in the jurisdictions examined, including the suggestion that there is a mounting onus on the realm of politics to translate the—largely positive—data from completed HAT science into corresponding policy and programming in order to expand effective treatment options for the high-risk population of illicit opioid users. PMID:17562183

  10. Application of Human-Autonomy Teaming (HAT) Patterns to Reduced Crew Operations (RCO)

    Science.gov (United States)

    Shively, R. Jay; Brandt, Summer L.; Lachter, Joel; Matessa, Mike; Sadler, Garrett; Battiste, Henri

    2016-01-01

    As part of the Air Force - NASA Bi-Annual Research Council Meeting, slides will be presented on recent Reduced Crew Operations (RCO) work. Unmanned aerial systems, robotics, advanced cockpits, and air traffic management are all examples of domains that are seeing dramatic increases in automation. While automation may take on some tasks previously performed by humans, humans will still be required, for the foreseeable future, to remain in the system. The collaboration with humans and these increasingly autonomous systems will begin to resemble cooperation between teammates, rather than simple task allocation. It is critical to understand this human-autonomy teaming (HAT) to optimize these systems in the future. One methodology to understand HAT is by identifying recurring patterns of HAT that have similar characteristics and solutions. A methodology for identifying HAT patterns to an advanced cockpit project is discussed.

  11. Application of Human-Autonomy Teaming (HAT) Patterns to Reduce Crew Operations (RCO)

    Science.gov (United States)

    Shively, R. Jay; Brandt, Summer L.; Lachter, Joel; Matessa, Mike; Sadler, Garrett; Battiste, Henri

    2016-01-01

    Unmanned aerial systems, robotics, advanced cockpits, and air traffic management are all examples of domains that are seeing dramatic increases in automation. While automation may take on some tasks previously performed by humans, humans will still be required, for the foreseeable future, to remain in the system. The collaboration with humans and these increasingly autonomous systems will begin to resemble cooperation between teammates, rather than simple task allocation. It is critical to understand this human-autonomy teaming (HAT) to optimize these systems in the future. One methodology to understand HAT is by identifying recurring patterns of HAT that have similar characteristics and solutions. This paper applies a methodology for identifying HAT patterns to an advanced cockpit project.

  12. Epigenetic control of learning and memory in Drosophila by Tip60 HAT action.

    Science.gov (United States)

    Xu, Songjun; Wilf, Rona; Menon, Trisha; Panikker, Priyalakshmi; Sarthi, Jessica; Elefant, Felice

    2014-12-01

    Disruption of epigenetic gene control mechanisms in the brain causes significant cognitive impairment that is a debilitating hallmark of most neurodegenerative disorders, including Alzheimer's disease (AD). Histone acetylation is one of the best characterized of these epigenetic mechanisms that is critical for regulating learning- and memory- associated gene expression profiles, yet the specific histone acetyltransferases (HATs) that mediate these effects have yet to be fully characterized. Here, we investigate an epigenetic role for the HAT Tip60 in learning and memory formation using the Drosophila CNS mushroom body (MB) as a well-characterized cognition model. We show that Tip60 is endogenously expressed in the Kenyon cells, the intrinsic neurons of the MB, and in the MB axonal lobes. Targeted loss of Tip60 HAT activity in the MB causes thinner and shorter axonal lobes while increasing Tip60 HAT levels cause no morphological defects. Functional consequences of both loss and gain of Tip60 HAT levels in the MB are evidenced by defects in immediate-recall memory. Our ChIP-Seq analysis reveals that Tip60 target genes are enriched for functions in cognitive processes, and, accordingly, key genes representing these pathways are misregulated in the Tip60 HAT mutant fly brain. Remarkably, we find that both learning and immediate-recall memory deficits that occur under AD-associated, amyloid precursor protein (APP)-induced neurodegenerative conditions can be effectively rescued by increasing Tip60 HAT levels specifically in the MB. Together, our findings uncover an epigenetic transcriptional regulatory role for Tip60 in cognitive function and highlight the potential of HAT activators as a therapeutic option for neurodegenerative disorders. Copyright © 2014 by the Genetics Society of America.

  13. Hats Off: A Study of Different Operating Room Headgear Assessed by Environmental Quality Indicators.

    Science.gov (United States)

    Markel, Troy A; Gormley, Thomas; Greeley, Damon; Ostojic, John; Wise, Angie; Rajala, Jonathan; Bharadwaj, Rahul; Wagner, Jennifer

    2017-11-01

    The effectiveness of operating room headgear in preventing airborne contamination has been called into question. We hypothesized that bouffant style hats would be as effective in preventing bacterial and particulate contamination in the operating room compared with disposable or cloth skull caps, and bouffant style hats would have similar permeability, particle penetration, and porosity compared with skull caps. Disposable bouffant and skull cap hats and newly laundered cloth skull caps were tested. A mock surgical procedure was used in a dynamic operating room environment. Airborne particulate and microbial contaminants were sampled. Hat fabric was tested for permeability, particle transmission, and pore sizes. No significant differences were observed between disposable bouffant and disposable skull caps with regard to particle or actively sampled microbial contamination. However, when compared with disposable skull caps, disposable bouffant hats did have significantly higher microbial shed at the sterile field, as measured by passive settle plate analysis (p particles and significantly higher microbial shed detected with passive analysis. Fabric assessment determined that disposable bouffant hats had larger average and maximum pore sizes compared with cloth skull caps, and were significantly more permeable than either disposable or cloth skull caps. Disposable bouffant hats had greater permeability, penetration, and greater microbial shed, as assessed by passive microbial analysis compared with disposable skull caps. When compared with cloth skull caps, disposable bouffants yielded greater permeability, greater particulate contamination, and greater passive microbial shed. Disposable style bouffant hats should not be considered superior to skull caps in preventing airborne contamination in the operating room. Copyright © 2017 American College of Surgeons. Published by Elsevier Inc. All rights reserved.

  14. Tip off the HAT- Epigenetic control of learning and memory by Drosophila Tip60.

    Science.gov (United States)

    Xu, Songjun; Elefant, Felice

    2015-01-01

    Disruption of epigenetic gene control mechanisms involving histone acetylation in the brain causes cognitive impairment, a debilitating hallmark of most neurodegenerative disorders. Histone acetylation regulates cognitive gene expression via chromatin packaging control in neurons. Unfortunately, the histone acetyltransferases (HATs) that generate such neural epigenetic signatures and their mechanisms of action remain unclear. Our recent findings provide insight into this question by demonstrating that Tip60 HAT action is critical for morphology and function of the mushroom body (MB), the learning and memory center in the Drosophila brain. We show that Tip60 is robustly produced in MB Kenyon cells and extending axonal lobes and that targeted MB Tip60 HAT loss results in axonal outgrowth disruption. Functional consequences of loss and gain of Tip60 HAT levels in the MB are evidenced by defects in memory. Tip60 ChIP-Seq analysis reveals enrichment for genes that function in cognitive processes and accordingly, key genes representing these pathways are misregulated in the Tip60 HAT mutant fly brain. Remarkably, increasing levels of Tip60 in the MB rescues learning and memory deficits resulting from Alzheimer's disease associated amyloid precursor protein (APP) induced neurodegeneration. Our studies highlight the potential of HAT activators as a therapeutic option for cognitive disorders.

  15. Gaussian-to-top-hat beam shaping: an overview of parameters, methods, and applications

    Science.gov (United States)

    Homburg, O.; Mitra, T.

    2012-02-01

    Direct laser patterning of various materials is today widely used in several micro-system production lines like inkjet printing, solar cell technology, flat-panel display production, LEDs, OLEDs, semiconductors and medicine. Typically single-mode solid state lasers and their higher harmonics (e. g. 266, 355, 532 and 1064 nm) are used especially for machining of holes and grooves. The striking advantages of flat top intensity distributions compared to Gaussian beam profiles with respect to the efficiency and quality of these processes were already demonstrated. Here we will give an overview of parameters, methods and applications of Gaussian-to-top-hat beam shaping. The top hat field size can start from about 30 μm with no upper size limitation in the far field of the optics. Beam shaping for various wavelengths were realized with field geometries of squares, rectangles and circles. With LIMO's compact Gaussian-to-top-hat converter an inhomogeneity better than 5% contrast was reached. Special focus is put on the integration of Gaussian-to-top-hat beam shapers in fast scanning systems employing Galvo mirrors and a specially developed f-Theta lens to avoid destruction of the top hat profile within the scan field. Results with a 50x50μm2 top hat size (inhomogeneity down to solar panels.

  16. HATS-50b through HATS-53b: Four Transiting Hot Jupiters Orbiting G-type Stars Discovered by the HATSouth Survey

    Science.gov (United States)

    Henning, Th.; Mancini, L.; Sarkis, P.; Bakos, G. Á.; Hartman, J. D.; Bayliss, D.; Bento, J.; Bhatti, W.; Brahm, R.; Ciceri, S.; Csubry, Z.; de Val-Borro, M.; Espinoza, N.; Fulton, B. J.; Howard, A. W.; Isaacson, H. T.; Jordán, A.; Marcy, G. W.; Penev, K.; Rabus, M.; Suc, V.; Tan, T. G.; Tinney, C. G.; Wright, D. J.; Zhou, G.; Durkan, S.; Lazar, J.; Papp, I.; Sari, P.

    2018-02-01

    We report the discovery of four close-in transiting exoplanets (HATS-50b through HATS-53b), discovered using the HATSouth three-continent network of homogeneous and automated telescopes. These new exoplanets belong to the class of hot Jupiters and orbit G-type dwarf stars, with brightness in the range V = 12.5–14.0 mag. While HATS-53 has many physical characteristics similar to the Sun, the other three stars appear to be metal-rich ([{Fe}/{{H}}]=0.2{--}0.3), larger, and more massive. Three of the new exoplanets, namely HATS-50b, HATS-51b, and HATS-53b, have low density (HATS-50b: 0.39+/- 0.10 {M}{{J}}, 1.130+/- 0.075 {R}{{J}}; HATS-51b: 0.768+/- 0.045 {M}{{J}}, 1.41+/- 0.19 {R}{{J}}; HATS-53b: 0.595+/- 0.089 {M}{{J}}, 1.340+/- 0.056 {R}{{J}}) and similar orbital periods (3.8297 days, 3.3489 days, 3.8538 days, respectively). Instead, HATS-52b is more dense (mass 2.24+/- 0.15 {M}{{J}} and radius 1.382+/- 0.086 {R}{{J}}) and has a shorter orbital period (1.3667 days). It also receives an intensive radiation from its parent star and, consequently, presents a high equilibrium temperature ({T}{eq}=1834+/- 73 K). HATS-50 shows a marginal additional transit feature consistent with an ultra-short-period hot super Neptune (upper mass limit 0.16 {M}{{J}}), which will be able to be confirmed with TESS photometry. The HATSouth network is operated by a collaboration consisting of Princeton University (PU), the Max Planck Institute für Astronomie (MPIA), the Australian National University (ANU), and the Pontificia Universidad Católica de Chile (PUC). The station at Las Campanas Observatory (LCO) of the Carnegie Institute is operated by PU in conjunction with PUC, the station at the High Energy Spectroscopic Survey (H.E.S.S.) site is operated in conjunction with MPIA, and the station at Siding Spring Observatory (SSO) is operated jointly with ANU. Based in part on observations made with the ESO 3.6 m, the NTT, the MPG 2.2 m and Euler 1.2 m Telescopes at the ESO Observatory in

  17. Remedial Action Plan for the codisposal and stabilization of the Monument Valley and Mexican Hat uranium mill tailings at Mexican Hat, Utah: Appendices C--E. Final report

    International Nuclear Information System (INIS)

    1993-02-01

    This document provides appendices C, D, and E this Remedial Action Plan (RAP) which is a revision of the original Mexican Hat Remedial Action Plan and RAP Modification submitted in July 1988 and January 1989, respectively, along with updated design documents. Appendix C provide the Radiological Support Plan, Appendix D provides the Site Characterization, and Appendix E provides the Water Resources Protection Strategy

  18. Remedial Action Plan for the codisposal and stabilization of the Monument Valley and Mexican Hat uranium mill tailings at Mexican Hat, Utah: Appendices C--E. Final report

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1993-02-01

    This document provides appendices C, D, and E this Remedial Action Plan (RAP) which is a revision of the original Mexican Hat Remedial Action Plan and RAP Modification submitted in July 1988 and January 1989, respectively, along with updated design documents. Appendix C provide the Radiological Support Plan, Appendix D provides the Site Characterization, and Appendix E provides the Water Resources Protection Strategy.

  19. Pope's hat sign: another valuable CT finding of early acute cholecystitis.

    Science.gov (United States)

    Choi, Seo-Youn; Lee, Hae Kyung; Yi, Boem Ha; Lee, Min Hee; Lee, Ji Eun; Min, Ji Hye; Moon, Ji Yoon; Kim, Jung Hoon

    2017-12-02

    To determine the diagnostic performance of minor computed tomography (CT) findings for acute cholecystitis and demonstrate the incremental benefit of pope's hat sign as an additional minor CT finding in patients suspected to have early acute cholecystitis. Two radiologists reviewed CT scans of 116 patients with early acute cholecystitis and 116 control patients. All cases in the patient group were surgically proven to have acute cholecystitis and preoperative dynamic CT scans. Evaluated CT parameters included major criteria (gallstone, distension of gallbladder (GB) lumen, GB wall edema, pericholecystic fat infiltration, and pericholecystic fluid collection) and minor criteria (GB bed hyperemia, tensile GB fundus sign, hyperdense GB wall sign, increased bile attenuation within GB, and pope's hat sign). In a univariate analysis, among the minor criteria, GB bed hyperemia, tensile GB fundus sign, increased bile attenuation within GB, and pope's hat sign were more frequently observed (P sign, and GB lumen > 3.05 cm were significant findings for differentiating the two groups (P sign exhibited the highest specificity (96.5%) and the combination of all three findings showed the highest sensitivity (94.0%). Pope's hat sign is a new finding that could improve CT diagnostic performance for early acute cholecystitis in patients with RUQ pain in the emergency department. The combination of pope's hat sign with GB bed hyperemia or GB lumen distension > 3.05 cm may be even more helpful in the early stage or in mild forms of acute cholecystitis.

  20. Material characterization with top-hat cw laser induced photothermal techniques: A short review

    International Nuclear Information System (INIS)

    Astrath, N G C; Shen, J; Astrath, F B G; Zhou, J; Baesso, M L; Malacarne, L C; Pedreira, P R B; Bento, A C

    2010-01-01

    In this work, we present a short review of the recent development of the theoretical models for top-hat cw laser induced spectroscopies of thermal lens and thermal mirror. With the same probe and top-hat excitation lasers, an apparatus is set up to concurrently measure both thermal lens and thermal mirror effects of transparent samples. With the theoretical models and the experimental apparatus, not only optical and thermal properties are measured, but also the fluorescence quantum coefficient and the temperature coefficient of the optical path length of a fluorescent sample are simultaneously determined with no need of any reference sample. Mechanical properties also could be measured. Opaque samples are also studied using top-hat cw laser thermal mirror and top-hat photothermal deflection techniques to determine thermal properties (e.g., thermal conductivity and unit volume specific heat). This work shows that the combined top-hat cw laser photothermal techniques are useful for nondestructive evaluation of both transparent and opaque samples with a less expensive non-TEM 00 Gaussian laser.

  1. Radiologic characterization of the Mexican Hat, Utah, uranium mill tailings remedial action site: Addendum D1

    Energy Technology Data Exchange (ETDEWEB)

    Ludlam, J.R.

    1985-01-01

    This radiologic characterization of the inactive uranium millsite at Mexican Hat, Utah, was conducted by Bendix Field Engineering Corporation for the US Department of Energy (DOE), Grand Junctions Project Office in response to and in accord with a Statement of Work prepared by the DOE Uranium Mill Tailings Remedial Action Project (UMTRAP) Technical Assistance Contractor, Jacobs Engineering Group, Inc. The objective of this project was to determine the horizontal and vertical extent of contamination that exceeds the US Environmental Protection Agency (EPA) standards at the Mexican Hat site. The data presented in this report are required for characterization of the areas adjacent to the Mexican Hat tailings piles and for the subsequent design of cleanup activities. Some on- pile sampling was required to determine the depth of the 15-pCi/g Ra- 226 interface in an area where wind and water erosion has taken place.

  2. HATS-1b: THE FIRST TRANSITING PLANET DISCOVERED BY THE HATSouth SURVEY

    Energy Technology Data Exchange (ETDEWEB)

    Penev, K.; Bakos, G. A.; Hartman, J. D.; Csubry, Z. [Department of Astrophysical Sciences, Princeton University, NJ 08544 (United States); Bayliss, D.; Zhou, G.; Conroy, P. [Australian National University, Canberra (Australia); Jordan, A.; Suc, V.; Rabus, M.; Brahm, R.; Espinoza, N. [Departamento de Astronomia y Astrofisica, Pontificia Universidad Catolica de Chile, Av. Vicuna Mackenna 4860, 7820436 Macul, Santiago (Chile); Mohler, M.; Mancini, L.; Henning, T.; Nikolov, N.; Csak, B. [Max Planck Institute for Astronomy, Heidelberg (Germany); Beky, B.; Noyes, R. W. [Harvard-Smithsonian Center for Astrophysics, Cambridge, MA (United States); Buchhave, L., E-mail: kpenev@astro.princeton.edu [Niels Bohr Institute, Copenhagen University (Denmark); and others

    2013-01-01

    We report the discovery of HATS-1b, a transiting extrasolar planet orbiting the moderately bright V = 12.05 G dwarf star GSC 6652-00186, and the first planet discovered by HATSouth, a global network of autonomous wide-field telescopes. HATS-1b has a period of P Almost-Equal-To 3.4465 days, mass of M{sub p} Almost-Equal-To 1.86 M{sub J}, and radius of R{sub p} Almost-Equal-To 1.30 R{sub J}. The host star has a mass of 0.99 M{sub Sun} and radius of 1.04 R{sub Sun }. The discovery light curve of HATS-1b has near-continuous coverage over several multi-day timespans, demonstrating the power of using a global network of telescopes to discover transiting planets.

  3. Analysis and test of superplastically formed titanium hat-stiffened panels under compression

    Science.gov (United States)

    Davis, Randall C.; Royster, Dick M.; Bales, Thomas T.

    1987-01-01

    Four hat-stiffened titanium panels with two different stiffener configurations were fabricated by superplastic forming/weld brazing and tested under a moderately heavy compressive load. The panels had the same overall dimensions but differed in the shape of the hat-stiffener webs; three panels had stiffeners with flat webs and the other panel had stiffeners with beaded webs. Analysis indicated that the local buckling strain of the flat stiffener web was considerably lower than the general panel buckling strain or cap buckling strain. The analysis also showed that beading the webs of the hat stiffeners removed them as the critical element for local buckling and improved the buckling strain of the panels. The analytical extensional stiffness and failure loads compared very well with experimental results.

  4. Targeting Specific HATs for Neurodegenerative Disease Treatment: Translating Basic Biology to Therapeutic Possibilities

    Directory of Open Access Journals (Sweden)

    Sheila K. Pirooznia

    2013-03-01

    Full Text Available Dynamic epigenetic regulation of neurons is emerging as a fundamental mechanism by which neurons adapt their transcriptional responses to specific developmental and environmental cues. While defects within the neural epigenome have traditionally been studied in the context of early developmental and heritable cognitive disorders, recent studies point to aberrant histone acetylation status as a key mechanism underlying acquired inappropriate alterations of genome structure and function in post-mitotic neurons during the aging process. Indeed, it is becoming increasingly evident that chromatin acetylation status can be impaired during the lifetime of neurons through mechanisms related to loss of function of histone acetyltransferase (HATs activity. Several HATs have been shown to participate in vital neuronal functions such as regulation of neuronal plasticity and memory formation. As such, dysregulation of such HATs has been implicated in the pathogenesis associated with age-associated neurodegenerative diseases and cognitive decline. In order to counteract the loss of HAT function in neurodegenerative diseases, the current therapeutic strategies involve the use of small molecules called histone deacetylase (HDAC inhibitors that antagonize HDAC activity and thus enhance acetylation levels. Although this strategy has displayed promising therapeutic effects, currently used HDAC inhibitors lack target specificity, raising concerns about their applicability. With rapidly evolving literature on HATs and their respective functions in mediating neuronal survival and higher order brain function such as learning and memory, modulating the function of specific HATs holds new promises as a therapeutic tool in neurodegenerative diseases. In this review, we focus on the recent progress in research regarding epigenetic histone acetylation mechanisms underlying neuronal activity and cognitive function. We discuss the current understanding of specific HDACs and

  5. Remedial Action Plan for the codisposal and stabilization of the Monument Valley and Mexican Hat uranium mill tailings at Mexican Hat, Utah

    International Nuclear Information System (INIS)

    1993-02-01

    This document is a revision of the original Mexiacan Hat Remedial Action Plan (RAP) and RAP Modification submitted in July 1988 and January 1989, respectively, along with updated design documents. This RAP has been developed to serve a two-fold purpose. It presents the activities proposed by the Department of Energy (DOE) to accomplish long-term stabilization and control of the residual radioactive materials (RRM) from Monument Valley, Arizona, and Mexican Hat, Utah, at the Mexican Hat disposal site. It also serves to document the concurrence of both the Navajo Nation and the Nuclear Regulatory Commission (NRC) in the remedial action. This agreement, upon execution by DOE and the Navajo Nation and concurrence by the NRC, becomes Appendix B of the Cooperative Agreement. This document has been structured to provide a comprehensive understanding of the remedial action proposed for the Monument Valley and Mexican Hat sites. It includes specific design and construction requirements for the remedial action. Pertinent information and data are included with reference given to the supporting documents. Section 2.0 presents the EPA standards, including a discussion of their objectives. Section 3. 0 summarizes the present site characteristics and provides a definition of site-specific problems. Section 4.0 is the site design for the proposed action. Section 5.0 presents the water resources protection strategy. Section 6.0 summarizes the plan for ensuring health and safety protection for the surrounding community and the on- site workers. Section 7.0 lists the responsibilities of the project participants. Section 8.0 describes the features of the long-term surveillance and maintenance plan

  6. Maximizing prosthetic valve size with the Top Hat supra-annular aortic valve

    DEFF Research Database (Denmark)

    Aagaard, Jan; Geha, Alexander S.

    2007-01-01

    BACKGROUND AND AIM OF THE STUDY: The CarboMedics Top Hat supra-annular aortic valve allows a one-size (and often two-size) increase over the standard intra-annular valve. This advantage should minimize the risk of patient-prosthesis mismatch, where the effective prosthetic valve orifice area...

  7. Hard Hats, Octopuses and Rubber Boots- Operational Managers in Building Processes

    DEFF Research Database (Denmark)

    Koch, Christian

    2004-01-01

    for these disturbances was coordination problems, but generally most types of interdependencies proved problematic. The needed skills for the site managers thus become those of the octopus handling processes in parallel with the necessary equipment of hard hats and rubber boots....

  8. Morphological hat-transform scale spaces and their use in pattern classification

    NARCIS (Netherlands)

    Jalba, Andrei C.; Wilkinson, Michael H.F.; Roerdink, Jos B.T.M.

    In this paper we present a multi-scale method based on mathematical morphology which can successfully be used in pattern classification tasks. A connected operator similar to the morphological hat-transform is defined, and two scale-space representations are built. The most important features are

  9. Planet-induced Stellar Pulsations in HAT-P-2's Eccentric System

    Energy Technology Data Exchange (ETDEWEB)

    Wit, Julien de [Department of Earth, Atmospheric and Planetary Sciences, MIT, 77 Massachusetts Avenue, Cambridge, MA 02139 (United States); Lewis, Nikole K. [Space Telescope Science Institute, 3700 San Martin Drive, Baltimore, MD 21218 (United States); Knutson, Heather A.; Batygin, Konstantin [Division of Geological and Planetary Sciences, California Institute of Technology, Pasadena, CA 91125 (United States); Fuller, Jim [TAPIR, Walter Burke Institute for Theoretical Physics, Mailcode 350-17, California Institute of Technology, Pasadena, CA 91125 (United States); Antoci, Victoria [Stellar Astrophysics Centre, Department of Physics and Astronomy, Aarhus University, Ny Munkegade 120, DK-8000 Aarhus C (Denmark); Fulton, Benjamin J. [Institute for Astronomy, University of Hawaii, Honolulu, HI 96822 (United States); Laughlin, Gregory [Department of Astronomy, Yale University, New Haven, CT 06511 (United States); Deming, Drake [Department of Astronomy, University of Maryland at College Park, College Park, MD 20742 (United States); Shporer, Avi [Jet Propulsion Laboratory, California Institute of Technology, 4800 Oak Grove Drive, Pasadena, CA 91009 (United States); Cowan, Nicolas B. [Department of Physics, Department of Earth and Planetary Sciences, McGill University, 3550 rue University, Montreal, QC H3A 2A7 (Canada); Agol, Eric [Department of Astronomy, University of Washington, Seattle, WA 98195 (United States); Burrows, Adam S. [Department of Astrophysical Sciences, Princeton University, Princeton, NJ 08544 (United States); Fortney, Jonathan J. [Department of Astronomy and Astrophysics, University of California, Santa Cruz, CA 95064 (United States); Langton, Jonathan [Department of Physics, Principia College, Elsah, IL 62028 (United States); Showman, Adam P. [Lunar and Planetary Laboratory, University of Arizona, Tucson, AZ 85721 (United States)

    2017-02-20

    Extrasolar planets on eccentric short-period orbits provide a laboratory in which to study radiative and tidal interactions between a planet and its host star under extreme forcing conditions. Studying such systems probes how the planet’s atmosphere redistributes the time-varying heat flux from its host and how the host star responds to transient tidal distortion. Here, we report the insights into the planet–star interactions in HAT-P-2's eccentric planetary system gained from the analysis of ∼350 hr of 4.5 μ m observations with the Spitzer Space Telescope . The observations show no sign of orbit-to-orbit variability nor of orbital evolution of the eccentric planetary companion, HAT-P-2 b. The extensive coverage allows us to better differentiate instrumental systematics from the transient heating of HAT-P-2 b’s 4.5 μ m photosphere and yields the detection of stellar pulsations with an amplitude of approximately 40 ppm. These pulsation modes correspond to exact harmonics of the planet’s orbital frequency, indicative of a tidal origin. Transient tidal effects can excite pulsation modes in the envelope of a star, but, to date, such pulsations had only been detected in highly eccentric stellar binaries. Current stellar models are unable to reproduce HAT-P-2's pulsations, suggesting that our understanding of the interactions at play in this system is incomplete.

  10. Planet-induced Stellar Pulsations in HAT-P-2's Eccentric System

    International Nuclear Information System (INIS)

    Wit, Julien de; Lewis, Nikole K.; Knutson, Heather A.; Batygin, Konstantin; Fuller, Jim; Antoci, Victoria; Fulton, Benjamin J.; Laughlin, Gregory; Deming, Drake; Shporer, Avi; Cowan, Nicolas B.; Agol, Eric; Burrows, Adam S.; Fortney, Jonathan J.; Langton, Jonathan; Showman, Adam P.

    2017-01-01

    Extrasolar planets on eccentric short-period orbits provide a laboratory in which to study radiative and tidal interactions between a planet and its host star under extreme forcing conditions. Studying such systems probes how the planet’s atmosphere redistributes the time-varying heat flux from its host and how the host star responds to transient tidal distortion. Here, we report the insights into the planet–star interactions in HAT-P-2's eccentric planetary system gained from the analysis of ∼350 hr of 4.5 μ m observations with the Spitzer Space Telescope . The observations show no sign of orbit-to-orbit variability nor of orbital evolution of the eccentric planetary companion, HAT-P-2 b. The extensive coverage allows us to better differentiate instrumental systematics from the transient heating of HAT-P-2 b’s 4.5 μ m photosphere and yields the detection of stellar pulsations with an amplitude of approximately 40 ppm. These pulsation modes correspond to exact harmonics of the planet’s orbital frequency, indicative of a tidal origin. Transient tidal effects can excite pulsation modes in the envelope of a star, but, to date, such pulsations had only been detected in highly eccentric stellar binaries. Current stellar models are unable to reproduce HAT-P-2's pulsations, suggesting that our understanding of the interactions at play in this system is incomplete.

  11. Six Thinking Hats and Social Workers' Innovative Competence: An Experimental Study

    Science.gov (United States)

    Azeez, Razaq Olugbenga

    2016-01-01

    Employees, no doubt, are the main force in organizations, and their innovative behaviours are vital for outcome efficacy. Innovative organisations, therefore, need creative employees who generate new ideas for product or process of innovation. This study investigated the effect of six thinking hats creativity technique on innovative competence of…

  12. Atmospheric circulation of eccentric hot Jupiter HAT-P-2B

    Energy Technology Data Exchange (ETDEWEB)

    Lewis, Nikole K. [Department of Earth, Atmospheric and Planetary Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139 (United States); Showman, Adam P. [Department of Planetary Sciences and Lunar and Planetary Laboratory, The University of Arizona, Tucson, AZ 85721 (United States); Fortney, Jonathan J. [Department of Astronomy and Astrophysics, University of California, Santa Cruz, CA 95064 (United States); Knutson, Heather A. [Division of Geological and Planetary Sciences, California Institute of Technology, Pasadena, CA 91125 (United States); Marley, Mark S., E-mail: nklewis@mit.edu [NASA Ames Research Center 245-3, Moffett Field, CA 94035 (United States)

    2014-11-10

    The hot Jupiter HAT-P-2b has become a prime target for Spitzer Space Telescope observations aimed at understanding the atmospheric response of exoplanets on highly eccentric orbits. Here we present a suite of three-dimensional atmospheric circulation models for HAT-P-2b that investigate the effects of assumed atmospheric composition and rotation rate on global scale winds and thermal patterns. We compare and contrast atmospheric models for HAT-P-2b, which assume one and five times solar metallicity, both with and without TiO/VO as atmospheric constituents. Additionally we compare models that assume a rotation period of half, one, and two times the nominal pseudo-synchronous rotation period. We find that changes in assumed atmospheric metallicity and rotation rate do not significantly affect model predictions of the planetary flux as a function of orbital phase. However, models in which TiO/VO are present in the atmosphere develop a transient temperature inversion between the transit and secondary eclipse events that results in significant variations in the timing and magnitude of the peak of the planetary flux compared with models in which TiO/VO are omitted from the opacity tables. We find that no one single atmospheric model can reproduce the recently observed full orbit phase curves at 3.6, 4.5 and 8.0 μm, which is likely due to a chemical process not captured by our current atmospheric models for HAT-P-2b. Further modeling and observational efforts focused on understanding the chemistry of HAT-P-2b's atmosphere are needed and could provide key insights into the interplay between radiative, dynamical, and chemical processes in a wide range of exoplanet atmospheres.

  13. HATS-17b: A Transiting Compact Warm Jupiter in a 16.3 Day Circular Orbit

    Science.gov (United States)

    Brahm, R.; Jordán, A.; Bakos, G. Á.; Penev, K.; Espinoza, N.; Rabus, M.; Hartman, J. D.; Bayliss, D.; Ciceri, S.; Zhou, G.; Mancini, L.; Tan, T. G.; de Val-Borro, M.; Bhatti, W.; Csubry, Z.; Bento, J.; Henning, T.; Schmidt, B.; Rojas, F.; Suc, V.; Lázár, J.; Papp, I.; Sári, P.

    2016-04-01

    We report the discovery of HATS-17b, the first transiting warm Jupiter of the HATSouth network. HATS-17b transits its bright (V = 12.4) G-type ({M}\\star = 1.131+/- 0.030 {M}⊙ , {R}\\star = {1.091}-0.046+0.070 {R}⊙ ) metal-rich ([Fe/H] = +0.3 dex) host star in a circular orbit with a period of P = 16.2546 days. HATS-17b has a very compact radius of 0.777+/- 0.056 {R}{{J}} given its Jupiter-like mass of 1.338+/- 0.065 {M}{{J}}. Up to 50% of the mass of HATS-17b may be composed of heavy elements in order to explain its high density with current models of planetary structure. HATS-17b is the longest period transiting planet discovered to date by a ground-based photometric survey, and is one of the brightest transiting warm Jupiter systems known. The brightness of HATS-17 will allow detailed follow-up observations to characterize the orbital geometry of the system and the atmosphere of the planet. The HATSouth network is operated by a collaboration consisting of Princeton University (PU), the Max Planck Institute für Astronomie (MPIA), the Australian National University (ANU), and the Pontificia Universidad Católica de Chile (PUC). The station at Las Campanas Observatory (LCO) of the Carnegie Institute is operated by PU in conjunction with PUC, the station at the High Energy Spectroscopic Survey (H.E.S.S.) site is operated in conjunction with MPIA, and the station at Siding Spring Observatory (SSO) is operated jointly with ANU. This paper includes data gathered with the MPG 2.2 m telescope at the ESO Observatory in La Silla and with the 3.9 m AAT in Siding Spring Observatory. This paper uses observations obtained with facilities of the Las Cumbres Observatory Global Telescope. Based on observations taken with the HARPS spectrograph (ESO 3.6 m telescope at La Silla) under programme 097.C-0571.

  14. Acoustic, fluorescent diagnosis of malignant lesions using HAT-D01 and ATX-S10

    Science.gov (United States)

    Nakajima, Susumu; Takemura, Takeshi; Sakata, Isao

    1995-03-01

    We have synthesized approximately 700 kinds of porphyrin derivatives and studied their side chain structures and affinities for tumor tissues. On the basis of these studies, a tumor localizing photo-chlorine photosensitizer named ATX-S10 has been synthesized for PDT and fluorescent diagnosis of malignant lesions. A non-photosensitive fluorescent diagnostic agent named HAT-D01 has also been synthesized. Both derivatives have the fluorescence near 680 nm that is far from the auto-fluorescence of biological tissue. For detection of tumor tissue, we have developed a new device that can pick up 670 - 680 nm fluorescence selectively and convert the intensity of fluorescence to the sound. By using this simple new device after ATX- S10, HAT-D01 administration we could detect well the malignant lesions.

  15. Characterizing Giant Exoplanets through Multiwavelength Transit Observations: HAT-P-57 b

    Science.gov (United States)

    Garver, Bethany Ray; Cole, Jackson Lane; Gardner, Cristilyn N.; Jarka, Kyla L.; Kar, Aman; McGough, Aylin M.; PeQueen, David Jeffrey; Rivera, Daniel Ivan; Kasper, David; Jang-Condell, Hannah; Kobulnicky, Henry; Dale, Daniel

    2018-01-01

    Giant planets have thick atmospheres. By observing transits through multiple filters at different wavelengths, we can make constraints on the atmospheres of those planets. When the planets are observed via transit, Rayleigh scattering can cause the transit depth to vary with wavelength. HAT-P-57 b is a giant exoplanet that is observable using the 2.3-meter telescope at the Wyoming Infrared Observatory. We observed half of a transit of HAT-P-57 b using Sloan filters g, r, i, and z. We present early results showing a variation in calculated radius with wavelength. Further observations are needed to confirm this variation and measure it more accurately. This work is supported by the National Science Foundation under REU grant AST 1560461.

  16. Potential ground water resources of Hat Yai Basin in Peninsular Thailand by gravity study

    Directory of Open Access Journals (Sweden)

    Warawutti Lohawijarn

    2005-05-01

    Full Text Available Residual gravity anomaly with a minimum of about -140 mm s-2 with approximately NS trend and a limited axial length was observed over Hat Yai Basin in Peninsular Thailand. The modeled Hat Yai basin is about 1 km deep at its deepest, 60 km long and 20 km wide. The porosity of basin sediment and the amount of potential ground water reserves within the basin are estimated to be 39% and 121.7±0.8 km3 respectively, assuming full saturation. Within the topmost 80 m of ground where the present extraction is concentrated, the estimated ground water reserve is 12.5±0.5 km3.

  17. Characterizing Giant Exoplanets through Multiwavelength Transit Observations: HAT-P-8b

    Science.gov (United States)

    Jarka, Kyla L.; Cole, Jackson Lane; Gardner, Cristilyn N.; Garver, Bethany Ray; Kar, Aman; McGough, Aylin Marie; PeQueen, David Jeffrey; Rivera, Daniel Ivan; Kasper, David; Jang-Condell, Hannah; Kobulnicky, Henry; Dale, Daniel

    2018-01-01

    Discovering and characterizing gas giants is important to the search for other life, as gas giants greatly affect the habitability of a solar system. Transits of exoplanets observed in visual photometric bands have been used to characterize their atmospheres and confirm planet parameters. We observed two primary transits of the hot gas giant HAT-P-8b with the Wyoming Infrared Observatory’s 2.3-meter telescope. Using multi-filter photometry in the g, r, i, and z bands (Sloan filters) we were able to update HAT-P-8b’s planet parameters and constrain characteristics of its atmosphere. Preliminary findings show that there is wavelength dependence in the depth of the transit observations. An infrared spectroscopic follow up of this candidate could yield more details on its atmospheric composition.

  18. Characterizing Giant Exoplanets through Multiwavelength Transit Observations: HAT-P-5 b

    Science.gov (United States)

    PeQueen, David Jeffrey; Cole, Jackson Lane; Gardner, Cristilyn N.; Garver, Bethany Ray; Jarka, Kyla L.; Kar, Aman; McGough, Aylin M.; Rivera, Daniel Ivan; Kasper, David; Jang-Condell, Hannah; Kobulnicky, Henry; Dale, Daniel

    2018-01-01

    During the summer of 2017, we observed hot Jupiter-type exoplanet transit events using the Wyoming Infrared Observatory’s 2.3 meter telescope. We observed 14 unique exoplanets during transit events; one such target was HAT-P-5 b. In total, we collected 53 usable science images in the Sloan filter set, particularly with the g’, r’, z’, and i’ band wavelength filters. This exoplanet transited approximately 40 minutes earlier than the currently published literature suggests. After reducing the data and running a Markov chain Monte Carlo analysis, we present results describing the planetary radius, semi-major axis, orbital period, and inclination of HAT-P-5 b. Characteristics of Rayleigh scattering are present in the atmosphere of this exoplanet. This work is supported by the National Science Foundation under REU grant AST 1560461.

  19. Laser direct micro-machining with top-hat-converted single mode lasers

    Science.gov (United States)

    Homburg, O.; Toennissen, F.; Mitra, T.; Lissotschenko, V.

    2008-02-01

    Laser direct micro-machining processes are used in a variety of industries like inkjet printing, semiconductor processing, solar technology, flat-panel display production and medicine. Various kinds of materials, e.g. ceramics, metals, isolators, oxides, organics and semiconductors are being structured. In most cases pulsed single mode solid state lasers with an inhomogeneous Gaussian beam profile are employed, like YAG lasers and their harmonics. However, the quality and functionality of the generated structures and micro-systems as well as the speed of the process can be improved by the utilization of homogeneous top hat profiles. The beam shaping principle of refractive Gaussian-to-top-hat converters is shown. Compact beam shaper modules based on this principle have been developed - supporting most direct laser micro-machining applications. The resulting process advantages are demonstrated by selected application results, namely the drilling of holes and patterning of trenches for different kinds of materials.

  20. HAT-P-26b: A Neptune-mass Exoplanet with Primordial Solar Heavy Element Abundance

    Science.gov (United States)

    Wakeford, Hannah R.; Sing, David K.; Kataria, Tiffany; Deming, Drake; Nikolov, Nikolay; Lopez, Eric; Tremblin, Pascal; Skalid Amundsen, David; Lewis, Nikole K.; Mandell, Avi; Fortney, Jonathan J.; Knutson, Heather; Benneke, Björn; Evans, Tom M.

    2017-01-01

    A trend in giant planet mass and atmospheric heavy elemental abundance was first noted last century from observations of planets in our own solar system. These four data points from Jupiter, Saturn, Uranus, and Neptune have served as a corner stone of planet formation theory. Here we add another point in the mass-metallicity trend from a detailed observational study of the extrasolar planet HAT-P-26b, which inhabits the critical mass regime near Neptune and Uranus. Neptune-sized worlds are among the most common planets in our galaxy and frequently exist in orbital periods very different from that of our own solar system ice giants. Atmospheric studies are the principal window into these worlds, and thereby into their formation and evolution, beyond those of our own solar system. Using the Hubble Space Telescope and Spitzer, from the optical to the infrared, we conducted a detailed atmospheric study of the Neptune-mass exoplanet HAT-P-26b over 0.5 to 4.5 μm. We detect prominent H2O absorption at 1.4 μm to 525 ppm in the atmospheric transmission spectrum. We determine that HAT-P-26b’s atmosphere is not rich in heavy elements (≈1.8×solar), which goes distinctly against the solar system mass-metallicity trend. This likely indicates that HAT-P-26b’s atmosphere is primordial and obtained its gaseous envelope late in its disk lifetime with little contamination from metal-rich planetesimals.

  1. The Γ-hat-genus and a regularization of an S1-equivariant Euler class

    International Nuclear Information System (INIS)

    Lu Rongmin

    2008-01-01

    We show that a new multiplicative genus, in the sense of Hirzebruch, can be obtained by generalizing a calculation due to Atiyah and Witten. We introduce this as the Γ-hat-genus, compute its value for some examples and highlight some of its interesting properties. We also indicate a connection with the study of multiple zeta values, which gives an algebraic interpretation for our proposed regularization procedure

  2. HAT-P-68b: A Transiting Hot Jupiter Around a K5 Dwarf Star

    Science.gov (United States)

    Lindor, Bethlee; Hartman, Joel D.

    2018-01-01

    One of the main goals of the astrophysical society has been to detect sources of life outside of Earth. To aid this search, astronomers have spent the last 2 decades focused on the discovery and characterization of exoplanets. The most effective method for doing so has been transit photometry, wherein we measure the brightness of stars over periods of time. These measurements, or light curves, are later analyzed for dips in brightness caused by objects passing in front of the star. However, variations in these time series can also occur due to non-planetary systems and a meticulous process is needed to distinguish the planets from the various false positives that are detected. HATNet is one of many surveys involved in this endeavor, and in this work I analyze HAT-P-68. First, I model the system as a single star with a transiting planet and derive estimates of the stellar and planetary physical parameters. I also model HAT-P-68 as a number of a false positives such as a pair of stars in an eclipsing binary blended with a background star, and a planet-sized star orbiting a Sun-like star. In order to rule out the possibility that HAT-P-68 is a blend, I carried out a statistical blend analysis of the photometric data and find that all blend models tested can be ruled out. Thus, I conclude that HAT-P-68 is a system with a transiting hot jupiter and consider what future observations would be most promising to further characterize the system.

  3. VizieR Online Data Catalog: Differential photometry of the EB* HATS551-027 (Zhou+, 2015)

    Science.gov (United States)

    Zhou, G.; Bayliss, D.; Hartman, J. D.; Rabus, M.; Bakos, G. A.; Jordan, A.; Brahm, R.; Penev, K.; Csubry, Z.; Mancini, L.; Espinoza, N.; de Val-Borro, M.; Bhatti, W.; Ciceri, S.; Henning, T.; Schmidt, B.; Murphy, S. J.; Butler, R. P.; Arriagada, P.; Shectman, S.; Crane, J.; Thompson, I.; Suc, V.; Noyes, R. W.

    2017-11-01

    The eclipses of HATS551-027 were first identified by observations from the HATSouth survey (Bakos et al. 2013PASP..125..154B). HATSouth is a global network of identical, fully robotic telescopes, providing continuous monitoring of selected 128 deg2 fields of the southern sky. A total of 16622 observations of HATS551-027 were obtained from HATSouth units HS-1, HS-2 in Chile, HS-3, HS-4 in Namibia, and HS-6 in Australia from 2009 September to 2010 September. Two secondary eclipses of HATS551-027 were observed by the Merope camera on 2-m Faulkes Telescope South (FTS), at Siding Spring Observatory, on 2012 December 12 and 2013 March 20. A near-complete primary eclipse of HATS551-027 was observed by the SITe#3 camera on the Swope 1 m telescope at Las Campanas Observatory, Chile, on 2013 February 26. (1 data file).

  4. iHAT: interactive Hierarchical Aggregation Table for Genetic Association Data

    Directory of Open Access Journals (Sweden)

    Heinrich Julian

    2012-05-01

    Full Text Available Abstract In the search for single-nucleotide polymorphisms which influence the observable phenotype, genome wide association studies have become an important technique for the identification of associations between genotype and phenotype of a diverse set of sequence-based data. We present a methodology for the visual assessment of single-nucleotide polymorphisms using interactive hierarchical aggregation techniques combined with methods known from traditional sequence browsers and cluster heatmaps. Our tool, the interactive Hierarchical Aggregation Table (iHAT, facilitates the visualization of multiple sequence alignments, associated metadata, and hierarchical clusterings. Different color maps and aggregation strategies as well as filtering options support the user in finding correlations between sequences and metadata. Similar to other visualizations such as parallel coordinates or heatmaps, iHAT relies on the human pattern-recognition ability for spotting patterns that might indicate correlation or anticorrelation. We demonstrate iHAT using artificial and real-world datasets for DNA and protein association studies as well as expression Quantitative Trait Locus data.

  5. Signatures of rocky planet engulfment in HAT-P-4. Implications for chemical tagging studies

    Science.gov (United States)

    Saffe, C.; Jofré, E.; Martioli, E.; Flores, M.; Petrucci, R.; Jaque Arancibia, M.

    2017-07-01

    Aims: We aim to explore the possible chemical signature of planet formation in the binary system HAT-P-4 by studying the trends of abundance vs. condensation temperature Tc. The star HAT-P-4 hosts a planet detected by transits, while its stellar companion does not have any detected planet. We also study the lithium content, which might shed light on the problem of Li depletion in exoplanet host stars. Methods: We derived for the first time both stellar parameters and high-precision chemical abundances by applying a line-by-line full differential approach. The stellar parameters were determined by imposing ionization and excitation equilibrium of Fe lines, with an updated version of the FUNDPAR program, together with ATLAS9 model atmospheres and the MOOG code. We derived detailed abundances of different species with equivalent widths and spectral synthesis with the MOOG program. Results: The exoplanet host star HAT-P-4 is found to be 0.1 dex more metal rich than its companion, which is one of the highest differences in metallicity observed in similar systems. This could have important implications for chemical tagging studies. We rule out a possible peculiar composition for each star, such as is the case for λ Boötis and δ Scuti, and neither is this binary a blue straggler. The star HAT-P-4 is enhanced in refractory elements relative to volatile when compared to its stellar companion. Notably, the Li abundance in HAT-P-4 is greater than that of its companion by 0.3 dex, which is contrary to the model that explains the Li depletion by the presence of planets. We propose a scenario where at the time of planet formation, the star HAT-P-4 locked the inner refractory material in planetesimals and rocky planets, and formed the outer gas giant planet at a greater distance. The refractories were then accreted onto the star, possibly as a result of the migration of the giant planet. This explains the higher metallicity, the higher Li content, and the negative Tc trend we

  6. [Fusion of dual color MWIR images based on support value transform and top-hat decomposition].

    Science.gov (United States)

    Lin, Su-Zhen; Yang, Feng-Bao; Chen, Lei

    2014-04-01

    Fusion method of dual color mid-wave infrared images is presented in this paper in order to solve such frequently rising issues as limited contrast ratio improvement and serious marginal area distortion in the fusion of the above two images using multi-scale top-hat decomposition. The detailed procedure is shown as the following: A low-frequency component image and a sequence of support value images of the two subdivision band images of mid-wave infrared are obtained respectively with support value transform. Multi-scale bright and dim information are first extracted from the last layer of low-frequency image using the multi-scale top-hat decomposition method respectively. Then they are fused by selecting the maximum gray of each pixel in two subdivision band images of mid-wave infrared respectively. Following that, the two resulted images are enhanced using the gray-scale normalization and Gaussian filtering and fused with the two low-frequency images to get the low-frequency fusion image. After that, this fusion image is reversely transformed with the support sequence image fused by selecting the maximum gray. The final image is got at last. The result shows that compared with the simple support value transform fusion and the multi-scale top-hat decomposition fusion, the method suggested in this paper successfully increases the contrast ratio by 11.69%, decreases the distortion factor by 63.42%, and increases the local coarseness by 38.12%. All these show that the validity of fusion method proposed has been proved, which indicates that both bright and dim information from low-frequency images can effectively solve the contradiction between improving fused image's contrast ratio and reducing its' distortion after the both are fused and enhanced respectively, and then fused with the two low-frequency images, which provides a new useful method for improving the quality of fused inferred images.

  7. REFINED SYSTEM PARAMETERS AND TTV STUDY OF TRANSITING EXOPLANETARY SYSTEM HAT-P-20

    Energy Technology Data Exchange (ETDEWEB)

    Sun, Leilei; Gu, Shenghong; Wang, Xiaobin; Cao, Dongtao; Wang, Yibo; Xiang, Yue [Yunnan Observatories, Chinese Academy of Sciences, Kunming 650011 (China); Cameron, Andrew Collier [School of Physics and Astronomy, University of St Andrews, North Haugh, St Andrews, Fife KY16 9SS (United Kingdom); Hui, Ho-Keung; Kwok, Chi-Tai [Ho Koon Nature Education cum Astronomical Centre, Sik Sik Yuen, Hong Kong (China); Yeung, Bill; Ng, Eric [Hong Kong Astronomical Society, Hong Kong (China); Horta, Ferran Grau, E-mail: wangxb@ynao.ac.cn [Observatori Ca l’Ou, C/de Dalt 18, Sant Martí Sesgueioles (Spain)

    2017-01-01

    We report new photometric observations of the transiting exoplanetary system HAT-P-20, obtained using CCD cameras at Yunnan Observatories and Ho Koon Nature Education cum Astronomical Centre, China, from 2010 to 2013, and Observatori Ca l’Ou, Sant Marti Sesgueioles, Spain, from 2013 to 2015. The observed data are corrected for systematic errors according to the coarse de-correlation and SYSREM algorithms, so as to enhance the signal of the transit events. In order to consistently model the star spots and transits of this exoplanetary system, we develop a highly efficient tool STMT based on the analytic models of Mandel and Agol and Montalto et al. The physical parameters of HAT-P-20 are refined by homogeneously analyzing our new data, the radial velocity data, and the earlier photometric data in the literature with the Markov chain Monte Carlo technique. New radii and masses of both host star and planet are larger than those in the discovery paper due to the discrepancy of the radius among K-dwarfs between predicted values by standard stellar models and empirical calibration from observations. Through the analysis of all available mid-transit times calculated with the normal model and spotted model, we conclude that the periodic transit timing variations in these transit events revealed by employing the normal model are probably induced by spot crossing events. From the analysis of the distribution of occulted spots by HAT-P-20b, we constrain the misaligned architecture between the planetary orbit and the spin of the host star.

  8. The Discovery of Ellipsoidal Variations in the Kepler Light Curve of HAT-P-7

    OpenAIRE

    Welsh, William F.; Orosz, Jerome A.; Seager, Sara; Fortney, Jonathan J.; Jenkins, Jon; Rowe, Jason F.; Koch, David; Borucki, William J.

    2010-01-01

    We present an analysis of the early Kepler observations of the previously discovered transiting planet HAT-P-7b. The light curve shows the transit of the star, the occultation of the planet, and the orbit phase-dependent light from the planet. In addition, phase-dependent light from the star is present, known as "ellipsoidal variations". The very nearby planet (only 4 stellar radii away) gravitationally distorts the star and results in a flux modulation twice per orbit. The ellipsoidal variat...

  9. The Occupancy Rate Modeling of Kendari Hotel Room using Mexican Hat Transformation and Partial Least Squares

    Directory of Open Access Journals (Sweden)

    Margaretha Ohyver

    2016-12-01

    Full Text Available Partial Least Squares (PLS method was developed in 1960 by Herman Wold. The method particularly suits with construct a regression model when the number of independent variables is many and highly collinear. The PLS can be combined with other methods, one of which is a Continuous Wavelet Transformation (CWT. By considering that the presence of outliers can lead to a less reliable model, and this kind of transformation may be required at a stage of pre-processing, the data is free of noise or outliers. Based on the previous study, Kendari hotel room occupancy rate was affected by the outlier, and it had a low value of R2. Therefore, this research aimed to obtain a good model by combining the PLS method and CWT transformation using the Mexican Hats them other wavelet of CWT. The research concludes that merging the PLS and the Mexican Hat transformation has resulted in a better model compared to the model that combined the PLS and the Haar wavelet transformation as shown in the previous study. The research shows that by changing the mother of the wavelet, the value of R2 can be improved significantly. The result provides information on how to increase the value of R2. The other advantage is the information for hotel managements to notice the age of the hotel, the maximum rates, the facilities, and the number of rooms to increase the number of visitors.

  10. Climatic change and environmental implications in the Medicine Hat region using Billings, Montana as an analogue

    International Nuclear Information System (INIS)

    Proudfoot, W.A.

    1994-01-01

    There is concern that climatic change due to anthropogenic enhancement of the greenhouse effect may have considerable impacts on the natural and agricultural environments in Canada. The Palliser Triangle in the southern prairie region is an area in which the impacts of climatic change could be significant; it is an important agricultural zone and is already sensitive due to its semi-arid climate. The possible effects of a change in the climate of the Medicine Hat (Alberta) area in the Palliser Triangle is examined through the use of a regional analogue in a warmer, more southerly area. The selected analogue region is the area around Billings, Montana. Aspects of the natural environment, including potential vegetation distribution, frost-free period, and drought, as well as aspects of the agricultural environment, including agricultural practices and examination of wheat yields, are studied within each region. Comparisons are drawn between the two regions to evaluate whether significant differences exist in the environmental aspects examined. It is shown that although a change in Medicine Hat's climate to one more like that of Billings may not have drastic impacts on the environment, such a change may require adjustments in current practices or adaptations to altered environmental conditions. Reviews of several policy areas will be necessary to ensure appropriate adjustments in agricultural or resource management practices. Regional analogy is shown to be an essential preliminary tool for determining possible effects of climatic change. 138 refs., 42 figs., 22 tabs

  11. FURTHER CONSTRAINTS ON THE OPTICAL TRANSMISSION SPECTRUM OF HAT-P-1b

    Energy Technology Data Exchange (ETDEWEB)

    Montalto, M.; Santos, N. C.; Martins, J. H. C.; Figueira, P.; Alonso, R. [Instituto de Astrofísica e Ciências do Espaço, Universidade do Porto, CAUP, Rua das Estrelas, PT4150-762 Porto (Portugal); Iro, N. [Theoretical Meteorology Group Klimacampus, University of Hamburg Grindelberg 5, D-20144, Hamburg (Germany); Desidera, S., E-mail: Marco.Montalto@astro.up.pt [INAF—Osservatorio Astronomico di Padova, Vicolo dellOsservatorio 5, Padova, I-35122 (Italy)

    2015-09-20

    We report on novel observations of HAT-P-1 aimed at constraining the optical transmission spectrum of the atmosphere of its transiting hot-Jupiter exoplanet. Ground-based differential spectrophotometry was performed over two transit windows using the DOLORES spectrograph at the Telescopio Nazionale Galileo. Our measurements imply an average planet to star radius ratio equal to R{sub p}/R{sub *} = (0.1159 ± 0.0005). This result is consistent with the value obtained from recent near-infrared measurements of this object, but differs from previously reported optical measurements, being lower by around 4.4 exoplanet scale heights. Analyzing the data over five different spectral bins of ∼600 Å wide, we observed a single peaked spectrum (3.7 σ level) with a blue cutoff corresponding to the blue edge of the broad absorption wing of sodium and an increased absorption in the region in-between 6180 and 7400 Å. We also infer that the width of the broad absorption wings due to alkali metals is likely narrower than the one implied by solar abundance clear atmospheric models. We interpret the result as evidence that HAT-P-1b has a partially clear atmosphere at optical wavelengths with a more modest contribution from an optical absorber than previously reported.

  12. Mexican-Hat-Like Response in a Flexible Tactile Sensor Using a Magnetorheological Elastomer

    Directory of Open Access Journals (Sweden)

    Takumi Kawasetsu

    2018-02-01

    Full Text Available A significant challenge in robotics is providing a sense of touch to robots. Even though several types of flexible tactile sensors have been proposed, they still have various technical issues such as a large amount of deformation that fractures the sensing elements, a poor maintainability and a deterioration in the sensitivity caused by the presence of a thick and soft covering. As one solution for these issues, we proposed a flexible tactile sensor composed of a magnet, magnetic transducer and dual-layer elastomer, which consists of a magnetorheological and nonmagnetic elastomer sheet. In this study, we first investigated the sensitivity of the sensor, which was found to be high (approximately 161 mV/N with a signal-to-noise ratio of 42.2 dB; however, the sensor has a speed-dependent hysteresis in its sensor response curve. Then, we investigated the spatial response and observed the following results: (1 the sensor response was a distorted Mexican-hat-like bipolar shape, namely a negative response area was observed around the positive response area; (2 the negative response area disappeared when we used a compressible sponge sheet instead of the incompressible nonmagnetic elastomer. We concluded that the characteristic negative response in the Mexican-hat-like response is derived from the incompressibility of the nonmagnetic elastomer.

  13. Radiologic characterization of the Mexican Hat, Utah, uranium mill tailings remedial action site: Appendix D, Addenda D1--D7

    Energy Technology Data Exchange (ETDEWEB)

    Ludlam, J.R.

    1985-01-01

    This radiologic characterization of the inactive uranium millsite at Mexican Hat, Utah, was conducted by Bendix Field Engineering Corporation foe the US Department of Energy (DOE), Grand Junction Project Office, in response to and in accord with a Statement of Work prepared by the DOE Uranium Mill tailings Remedial Action Project (UMTRAP) Technical Assistance Contractor, Jacobs Engineering Group, Inc. the objective of this project was to determine the horizontal and vertical extent of contamination that exceeds the US Environmental Protection Agency (EPA) standards at the Mexican Hat site. The data presented in this report are required for characterization of the areas adjacent to the Mexican Hat tailings piles and for the subsequent design of cleanup activities. Some on-pile sampling was required to determine the depth of the 15-pCi/g Ra-226 interface in an area where wind and water erosion has taken place.

  14. HAT-P-26b: A Neptune-mass exoplanet with a well-constrained heavy element abundance.

    Science.gov (United States)

    Wakeford, Hannah R; Sing, David K; Kataria, Tiffany; Deming, Drake; Nikolov, Nikolay; Lopez, Eric D; Tremblin, Pascal; Amundsen, David S; Lewis, Nikole K; Mandell, Avi M; Fortney, Jonathan J; Knutson, Heather; Benneke, Björn; Evans, Thomas M

    2017-05-12

    A correlation between giant-planet mass and atmospheric heavy elemental abundance was first noted in the past century from observations of planets in our own Solar System and has served as a cornerstone of planet-formation theory. Using data from the Hubble and Spitzer Space Telescopes from 0.5 to 5 micrometers, we conducted a detailed atmospheric study of the transiting Neptune-mass exoplanet HAT-P-26b. We detected prominent H 2 O absorption bands with a maximum base-to-peak amplitude of 525 parts per million in the transmission spectrum. Using the water abundance as a proxy for metallicity, we measured HAT-P-26b's atmospheric heavy element content ([Formula: see text] times solar). This likely indicates that HAT-P-26b's atmosphere is primordial and obtained its gaseous envelope late in its disk lifetime, with little contamination from metal-rich planetesimals. Copyright © 2017, American Association for the Advancement of Science.

  15. Earthquake Hazard and Segmented Fault Evolution, Hat Creek Fault, Northern California

    Science.gov (United States)

    Blakeslee, M. W.; Kattenhorn, S. A.

    2010-12-01

    Precise insight into surface rupture and the evolution and mechanical interaction of segmented normal fault systems is critical for assessing the potential seismic hazard. The Hat Creek fault is a ~35 km long, NNW trending segmented normal fault system located on the western boundary of the Modoc Plateau and within the extending backarc basin of the Cascadia subduction zone in northern California. The Hat Creek fault has a prominent surface rupture showing evidence of multiple events in the past 15 ka, although there have been no historic earthquakes. In response to interactions with volcanic activity, the fault system has progressively migrated several km westward, causing older scarps to become seemingly inactive, and producing three distinct, semi-parallel scarps with different ages. The oldest scarp, designated the “Rim”, is the farthest west and has up to 352 m of throw. The relatively younger “Pali” scarp has up to 174 m of throw. The young “Active” scarp has a maximum throw of 65 m in the 24±6 ka Hat Creek basalt, with 20 m of throw in ~15 ka glacial gravels (i.e., a Holocene slip rate of ~1.3 mm/yr). Changes in the geometry and kinematics of the separate scarps during the faulting history imply the orientation of the stress field has rotated clockwise, now inducing oblique right-lateral motion. Previous studies suggested that the Active scarp consists of 7 left-stepping segments with a cumulative length of 23.5 km. We advocate that the Active scarp is actually composed of 8 or 9 segments and extends 4 km longer than previous estimates. This addition to the active portion of the fault is based on detailed mapping of a young surface rupture in the northern portion of the fault system. This ~30 m high young scarp offsets lavas that erupted from Cinder Butte, a low shield volcano, but has a similar geometry and properties as the Active scarp in the Hat Creek basalt. At its northern end, the Active scarp terminates at Cinder Butte. Our mapping

  16. Engineering assessment of inactive uranium mill tailings, Mexican Hat site, Mexican Hat, Utah. A summary of the Phase II, Title I

    International Nuclear Information System (INIS)

    1977-01-01

    Ford, Bacon and Davis Utah Inc. has performed an engineering assessment of the problems resulting from the existence of radioactive uranium mill tailings at the Mexican Hat millsite in Utah. The Phase II, Title I services include the preparation of topographic maps, the performance of core drillings and radiometric measurements sufficient to determine areas and volumes of tailings and other radium-contaminated materials, the evaluation of resulting radiation exposures of individuals residing nearby, the investigation of site hydrology and meteorology, and the evaluation and costing of alternative corrective actions. Radon gas release from the 2,200,000 tons of tailings on the site constitutes the most significant environmental impact. The six alternative actions presented are directed towards restricting access to the site (Option I), returning the windblown tailings to the piles and stabilizing the piles with cover material (Options II, III, and IV), and consolidating the two piles into one pile and stabilizing it with cover material (Options V and VI). Fencing around the site or the tailings and the decontamination of mill buildings is included in all options. Options II and V provide 2 ft of cover material on the tailings, Options III, IV, and VI provide 4 ft, 13 ft, and 10 ft of cover, respectively. Costs of the options range from $370,000 to $4,390,000. Reprocessing the tailings for uranium is not feasible at present

  17. Final audit report of remedial action construction at the UMTRA Project Mexican Hat, Utah -- Monument Valley, Arizona, sites

    International Nuclear Information System (INIS)

    1995-10-01

    The final audit report for remedial action at the Mexican Hat, Utah, Monument Valley, Arizona, Uranium Mill Tailings Remedial Action (UMTRA) Project sites consists of a summary of the radiological surveillances/audits, quality assurance (QA) in-process surveillances, and QA remedial action close-out inspections performed by the US Department of Energy (DOE) and the Technical Assistance Contractor (TAC); on-site construction reviews (OSCR) performed by the US Nuclear Regulatory Commission (NRC); and a surveillance performed by the Navajo Nation. This report refers to remedial action activities performed at the Mexican Hat, Utah--Monument Valley, Arizona, Uranium Mill Tailings Remedial Action (UMTRA) Project sites

  18. Observations and modeling of the transiting exoplanets XO-2b, HAT-P-18b, and WASP-80b

    Directory of Open Access Journals (Sweden)

    Kjurkchieva Diana P.

    2017-01-01

    Full Text Available We present photometric observations and transit solutions of the exoplanets XO-2b, HAT-P-18b and WASP 80b. Our solution of the XO-2b transit gave system parameters whose values are close to those of the previous studies. The solutions of the new transits of HAT-P-18b and WASP 80b differ from the previous ones by bigger stellar and planet radii. We obtained new values of the target initial epochs corresponding to slightly different periods. Our investigation reaffirmed that small telescopes can be used successfully for the study of exoplanets orbiting stars brighter than 13 mag.

  19. HAT-P-65b and HAT-P-66b: Two Transiting Inflated Hot Jupiters and Observational Evidence for the Reinflation of Close-in Giant Planets

    Science.gov (United States)

    Hartman, J. D.; Bakos, G. Á.; Bhatti, W.; Penev, K.; Bieryla, A.; Latham, D. W.; Kovács, G.; Torres, G.; Csubry, Z.; de Val-Borro, M.; Buchhave, L.; Kovács, T.; Quinn, S.; Howard, A. W.; Isaacson, H.; Fulton, B. J.; Everett, M. E.; Esquerdo, G.; Béky, B.; Szklenar, T.; Falco, E.; Santerne, A.; Boisse, I.; Hébrard, G.; Burrows, A.; Lázár, J.; Papp, I.; Sári, P.

    2016-12-01

    We present the discovery of the transiting exoplanets HAT-P-65b and HAT-P-66b, with orbital periods of 2.6055 and 2.9721 days, masses of 0.527+/- 0.083 {M}{{J}} and 0.783+/- 0.057 {M}{{J}}, and inflated radii of 1.89+/- 0.13 {R}{{J}} and {1.59}-0.10+0.16 {R}{{J}}, respectively. They orbit moderately bright (V=13.145+/- 0.029 and V=12.993+/- 0.052) stars of mass 1.212+/- 0.050 {M}⊙ and {1.255}-0.054+0.107 {M}⊙ . The stars are at the main-sequence turnoff. While it is well known that the radii of close-in giant planets are correlated with their equilibrium temperatures, whether or not the radii of planets increase in time as their hosts evolve and become more luminous is an open question. Looking at the broader sample of well-characterized close-in transiting giant planets, we find that there is a statistically significant correlation between planetary radii and the fractional ages of their host stars, with a false-alarm probability of only 0.0041%. We find that the correlation between the radii of planets and the fractional ages of their hosts is fully explained by the known correlation between planetary radii and their present-day equilibrium temperatures; however, if the zero-age main-sequence equilibrium temperature is used in place of the present-day equilibrium temperature, then a correlation with age must also be included to explain the planetary radii. This suggests that, after contracting during the pre-main-sequence, close-in giant planets are reinflated over time due to the increasing level of irradiation received from their host stars. Prior theoretical work indicates that such a dynamic response to irradiation requires a significant fraction of the incident energy to be deposited deep within the planetary interiors. Based on observations obtained with the Hungarian-made Automated Telescope Network. Based on observations obtained at the W. M. Keck Observatory, which is operated by the University of California and the California Institute of Technology

  20. Soft computing for modeling the value of social capital at Red Hat

    OpenAIRE

    Siderska, Julia

    2014-01-01

    Artykuł finansowany ze stypendium naukowe w ramach projektu Urzędu Marszałkowskiego Województwa Podlaskiego „Stypendia dla doktorantów województwa podlaskiego” finansowanego w ramach Działania 8.2 – Transfer Wiedzy, Poddziałanie 8.2.2 – Regionalne Strategie Innowacji, Priorytet VIII PO KL, współfinansowanego ze środków EFS, budżetu państwa oraz środków budżetu województwa podlaskiego. The main objective of this paper is to predict the value of social capital at Red Hat Corporation, using a...

  1. Assessment of the radiological impact of the inactive uranium-mill tailings at Mexican Hat, Utah

    International Nuclear Information System (INIS)

    Haywood, F.F.; Goldsmith, W.A.; Ellis, B.S.; Hubbard, H.M. Jr.; Fox, W.F.; Shinpaugh, W.H.

    1980-03-01

    High surface soil concentrations of 226 Ra and high above-ground measurements of gamma-ray intensity in the vicinity of the inactive uranium-mill tailings at Mexican Hat show both wind and water erosion of the tailings. The former mill area, occupied by a trade school at the time of this survey, shows a comparatively high level of contamination, probably from unprocessed ore on the surface of the ore storage area near the location of the former mill buildings. However, the estimated health effect of exposure to gamma rays during a 2000-hr work year in the area represents an increase of 0.1% in the risk of death from cancer. Exposure of less than 600 persons within 1.6 km of the tailings to radon daughters results in an estimated 0.2%/year increase in risk of lung cancer

  2. An Overview of HATS: A Language Independent High Assurance Transformation System

    Energy Technology Data Exchange (ETDEWEB)

    Winter, V.L.

    1998-10-16

    Transformations that are based on syntax directed rewriting systems can have a significant impact on the construction of high assurance systems. However, in order for a transformational approach to be useful to a particular problem domain, a (general) transformation system must be adapted to the notation of that particular domain. A transformation system that can be easily adapted to various domain notations has the potential of having a wide range of applicability. In this paper we dissus why transforrmtion is attractive horn a high assurance perspective, as well as some issues surrounding automated transformation within specific problem domains. We then give an overview of a language independent High Assurance Transformation System (HATS) that is being developed at Sandia National Laboratories.

  3. Design of hat-stiffened composite panels loaded in axial compression

    Science.gov (United States)

    Paul, T. K.; Sinha, P. K.

    An integrated step-by-step analysis procedure for the design of axially compressed stiffened composite panels is outlined. The analysis makes use of the effective width concept. A computer code, BUSTCOP, is developed incorporating various aspects of buckling such as skin buckling, stiffener crippling and column buckling. Other salient features of the computer code include capabilities for generation of data based on micromechanics theories and hygrothermal analysis, and for prediction of strength failure. Parametric studies carried out on a hat-stiffened structural element indicate that, for all practical purposes, composite panels exhibit higher structural efficiency. Some hybrid laminates with outer layers made of aluminum alloy also show great promise for flight vehicle structural applications.

  4. Simulated response of top-hat electrostatic analysers - importance of phase-space resolution

    Science.gov (United States)

    De Marco, Rossana; Bruno, Roberto; D'Amicis, Raffaella; Federica Marcucci, Maria; Servidio, Sergio; Valentini, Francesco

    2016-04-01

    We use a numerical code able to reproduce the angular/energy response of a typical electrostatic analyzer of top-hat type starting from velocity distribution functions (VDFs) generated by numerical imulations.The simulations are based on the Hybrid Vlasov-Maxwell (HVM) numerical algorithm which integrates the Vlasov equation for the ion distribution function in multi-dimensional geometry in phase space, while the electrons are treated as a fluid. Virtual satellites launched through the simulation box measure the particle VDFs. Such VDFs are interpolated into a spacecraft reference frame and moved from the simulation Cartesian grid to energy-angular coordinates to mimic the response of a real electrostatic sensor in the solar wind and in the magnetosheath for different conditions. We discuss the results of this study with respect to the importance of phase-space resolution for a space plasma experiment meant to investigate kinetic plasma regime.

  5. A near-infrared transmission spectrum for the warm Saturn HAT-P-12b

    International Nuclear Information System (INIS)

    Line, Michael R.; Knutson, Heather; Desert, Jean-Michel; Deming, Drake; Wilkins, Ashlee

    2013-01-01

    We present a Hubble Space Telescope Wide Field Camera-3 (WFC3) transmission spectrum for the transiting exoplanet HAT-P-12b. This warm (1000 K) sub-Saturn-mass planet has a smaller mass and a lower temperature than the hot Jupiters that have been studied so far. We find that the planet's measured transmission spectrum lacks the expected water absorption feature for a hydrogen-dominated atmosphere and is instead best described by a model with high-altitude clouds. Using a frequentist hypothesis testing procedure, we can rule out a hydrogen-dominated cloud-free atmosphere to 4.9σ. When combined with other recent WFC3 studies, our observations suggest that clouds may be common in exoplanetary atmospheres.

  6. Analysis of web defects by correlating 1-D Morlet and 2-D Mexican hat wavelet transforms

    Science.gov (United States)

    Lewalle, Jacques; Keller, D. Steven

    2005-11-01

    The manufacturing processes for paper and similar non-woven fiber webs can affect end-use properties. In this paper, we document a new wavelet-based method of product diagnostic. The methods combines 1-dimensional Morlet and isotropic 2-dimensional Mexican hat wavelets, with wavelet-based filtering and denoising techniques. Two samples produced in pilot machines by different forming methods are examined for variations in their mass per unit area - the grammage. The grammage maps are decomposed into three layers: one associated with the nearly-periodic grammage streaks at large scale, one associated with flocs or related medium-size structures, and the background which combines pixel-size fluctuations and large-scale stochastic modulations. By correlating the structure and background fluctuations with the streaks local phase, we show that one sample exhibits formation streaks (statistical variations in properties other than mean grammage), which are not found in the other.

  7. "It's your badge of inclusion": the Red Hat Society as a gendered subculture of aging.

    Science.gov (United States)

    Barrett, Anne E; Pai, Manacy; Redmond, Rebecca

    2012-12-01

    Although studies document the health-enhancing effects of social engagement, they reveal little about the underlying mechanisms operating within specific organizational contexts. Limited attention is given to the role of inequality--particularly age and gender--in shaping either the organizations to which we belong or their consequences for our well-being. We address this issue by examining the Red Hat Society, a social organization for middle-aged and older women. Interviews with members (n=52) illustrate how age and gender inequality interact to shape the organization, which can be viewed as a gendered subculture of aging. Drawing on this framework, we discuss four processes through which participation generates benefits for older women involved in age- and gender-segregated organizations: enhancing social networks, countering invisibility, creating positive frames for aging experiences, and promoting youthful identities. Copyright © 2012 Elsevier Inc. All rights reserved.

  8. Using Edward de Bono's six hats game to aid critical thinking and reflection in palliative care.

    Science.gov (United States)

    Kenny, Lesley J

    2003-03-01

    This article describes the use of a creative thinking game to stimulate critical thinking and reflection with qualified health professionals undertaking palliative care education. The importance of reflective practice in nursing is well documented and numerous models are available. However, the author as a nurse teacher has found that many of these models are either too simple or too complex to be valuable in practice. The six hats game, devised by Edward de Bono, is a method that stimulates a variety of types of thinking and when used as a means of reflection helps students to become more critical about their practice. Using this game with a palliative care case study the author demonstrates how thinking more creatively about the patients' perceived needs and problems can assist in developing reflective skills. The article concludes with a discussion on some of the challenges of using this method and suggestions for future practical uses.

  9. 3D spin-orbit angle of Kepler-25 and HAT-P-7

    Directory of Open Access Journals (Sweden)

    Benomar Othman

    2015-01-01

    Full Text Available The number of discovered exoplanets now exceeds 1500, mostly due to the Kepler space instrument observations. Many of these planet orbit in less than a week around their host stars. This implies that the inward migration of those planets is a basic ingredient of successful theories of planet formation and evolution. Several mechanisms have been proposed to explain the observed periods, which lead to different orbit eccentricity and obliquity distributions. Here we summarise and discuss the results of obliquities for two Kepler stars: HAT-P-7 and Kepler-25. These are interesting stellar systems as we could carry out a joint analysis using asteroseismology, transit lightcurve and the Rossiter-McLaughlin effect in order to measure the three dimensional obliquity.

  10. Spherical top-hat collapse of a viscous unified dark fluid

    Energy Technology Data Exchange (ETDEWEB)

    Li, Wei [Bohai University, Department of Physics, Jinzhou (China); Dalian University of Technology, Institute of Theoretical Physics, Dalian (China); Xu, Lixin [Dalian University of Technology, Institute of Theoretical Physics, Dalian (China)

    2014-05-15

    In this paper, we test the spherical collapse of a viscous unified dark fluid (VUDF) which has constant adiabatic sound speed and show the nonlinear collapse for VUDF, baryons, and darkmatter, which are important in forming the large-scale structure of our Universe. By varying the values of the model parameters α and ζ{sub 0}, we discuss their effects on the nonlinear collapse of the VUDF model, and we compare its result to the ΛCDM model. The results of the analysis show that, within the spherical top-hat collapse framework, larger values of α and smaller values of ζ{sub 0} make the structure formation earlier and faster, and the other collapse curves are almost distinguished with the curve of ΛCDM model if the bulk viscosity coefficient ζ{sub 0} is less than 10{sup -3}. (orig.)

  11. Relativistic and correlation effects on molecular properties .2. The hydrogen halides HF, HCl, HBr, HI, and HAt

    NARCIS (Netherlands)

    Visscher, L; Styszynski, J.; Nieuwpoort, W.C

    1996-01-01

    A benchmark study of a number of four-component relativistic correlation methods is presented. Bond lengths, harmonic frequencies, and dissociation energies of the molecules HF, HCl, HBr, HI, and HAt are calculated at various levels of theory, using both the Schrodinger and the Dirac-Coulomb-(Gaunt)

  12. Possible formation pathways for the low-density Neptune-mass planet HAT-P-26b

    Science.gov (United States)

    Ali-Dib, Mohamad; Lakhlani, Gunjan

    2018-01-01

    We investigate possible pathways for the formation of the low-density Neptune-mass planet HAT-P-26b. We use two different formation models based on pebble and planetesimal accretion, and includes gas accretion, disc migration and simple photoevaporation. The models track the atmospheric oxygen abundance, in addition to the orbital period, and mass of the forming planets, which we compare to HAT-P-26b. We find that pebble accretion can explain this planet more naturally than planetesimal accretion that fails completely unless we artificially enhance the disc metallicity significantly. Pebble accretion models can reproduce HAT-P-26b with either a high initial core mass and low amount of envelope enrichment through core erosion or pebbles dissolution, or the opposite, with both scenarios being possible. Assuming a low envelope enrichment factor as expected from convection theory and comparable to the values we can infer from the D/H measurements in Uranus and Neptune, our most probable formation pathway for HAT-P-26b is through pebble accretion starting around 10 au early in the disc's lifetime.

  13. Survey of sugar beet (Beta vulgaris L.) hAT transposons and MITE-like hATpin derivatives.

    Science.gov (United States)

    Menzel, Gerhard; Krebs, Carmen; Diez, Mercedes; Holtgräwe, Daniela; Weisshaar, Bernd; Minoche, André E; Dohm, Juliane C; Himmelbauer, Heinz; Schmidt, Thomas

    2012-03-01

    Genome-wide analyses of repetitive DNA suggest a significant impact particularly of transposable elements on genome size and evolution of virtually all eukaryotic organisms. In this study, we analyzed the abundance and diversity of the hAT transposon superfamily of the sugar beet (B. vulgaris) genome, using molecular, bioinformatic and cytogenetic approaches. We identified 81 transposase-coding sequences, three of which are part of structurally intact but nonfunctional hAT transposons (BvhAT), in a B. vulgaris BAC library as well as in whole genome sequencing-derived data sets. Additionally, 116 complete and 497 truncated non-autonomous BvhAT derivatives lacking the transposase gene were in silico-detected. The 116 complete derivatives were subdivided into four BvhATpin groups each characterized by a distinct terminal inverted repeat motif. Both BvhAT and BvhATpin transposons are specific for species of the genus Beta and closely related species, showing a localization on B. vulgaris chromosomes predominantely in euchromatic regions. The lack of any BvhAT transposase function together with the high degree of degeneration observed for the BvhAT and the BvhATpin genomic fraction contrasts with the abundance and activity of autonomous and non-autonomous hAT transposons revealed in other plant species. This indicates a possible genus-specific structural and functional repression of the hAT transposon superfamily during Beta diversification and evolution.

  14. Inhibition of Different Histone Acetyltransferases (HATs) Uncovers Transcription-Dependent and -Independent Acetylation-Mediated Mechanisms in Memory Formation

    Science.gov (United States)

    Merschbaecher, Katja; Hatko, Lucyna; Folz, Jennifer; Mueller, Uli

    2016-01-01

    Acetylation of histones changes the efficiency of the transcription processes and thus contributes to the formation of long-term memory (LTM). In our comparative study, we used two inhibitors to characterize the contribution of different histone acetyl transferases (HATs) to appetitive associative learning in the honeybee. For one we applied…

  15. Development of a helmet/helmet-display-unit alignment tool (HAT) for the Apache helmet and display unit

    Science.gov (United States)

    McLean, William; Statz, Jonathan; Estes, Victor; Booms, Shawn; Martin, John S.; Harding, Thomas

    2015-05-01

    Project Manager (PM) Apache Block III contacted the U.S. Army Aeromedical Research Laboratory (USAARL), Fort Rucker, Alabama, requesting assistance to evaluate and find solutions to a government-developed Helmet Display Unit (HDU) device called the Mock HDU for helmet alignment of the Apache Advanced Integrated Helmet (AAIH). The AAIH is a modified Head Gear Unit No. 56 for Personnel (HGU-56/P) to replace the current Integrated Helmet and Sighting System (IHADSS). The current flashlight-based HDU simulator for helmet/HDU alignment was no longer in production or available. Proper helmet/HDU alignment is critical to position the right eye in the small HDU eye box to obtain image alignment and full field of view (FOV). The initial approach of the PM to developing a helmet/HDU fitting device (Mock HDU) was to duplicate the optical characteristics of the current tactical HDU using less complex optics. However, the results produced questionable alignment, FOV, and distortion issues, with cost and development time overruns. After evaluating the Mock HDU, USAARL proposed a cost effective, less complex optical design called the Helmet/HDU Alignment Tool (HAT). This paper will show the development, components, and evaluations of the HAT compared to the current flashlight HDU simulator device. The laboratory evaluations included FOV measurements and alignment accuracies compared to tactical HDUs. The Apache helmet fitter technicians and Apache pilots compared the HAT to the current flashlight based HDU and ranked the HAT superior.

  16. BALTIMORE’S M.S. LEVY AND SONS: Straw Hat Makers to the World, 1870-1960

    Directory of Open Access Journals (Sweden)

    Jessica I. Elfenbein

    2008-01-01

    Full Text Available From 1860 to 1960, Baltimore was an important center of the men’s ready-to- wear clothing industries. German-speaking Jews created many businesses that manufactured and sold underwear, men’s suits, and specialty items like hats and umbrellas. The straw hat making firm started by M.S. Levy is an interesting example of a Baltimore-based, family-owned niche business that existedfor 90 years, through three generations ofa singlefamily. The M.S. Levy and Sons story has two main chapters. The first covers the period from its founding by Michael Simon Levy in the 1870s through his son Julius’ death in 1926. This is the story of ascension. A premonition about the coming popularity of straw hats, together with a small but important technological breakthrough, positioned a family and a small industry for significant expansion. The second period began in 1930 with the introduction of wool felt hats and the death of William, M.S. Levy’s oldest son, and includes the Great Depression, unionization, merger, third generation leadership, and finally, in 1959, the family’s withdrawal from the industry. This later period, as told by grandsons of the founder, is the story of struggle followed by decline.

  17. TCUP: A novel hAT transposon active in maize tissue culture

    Directory of Open Access Journals (Sweden)

    Alan eSmith

    2012-01-01

    Full Text Available Transposable elements are capable of inducing heritable de novo genetic variation. The sequences capable of reactivation, and environmental factors that induce mobilization, remain poorly defined even in well-studied genomes such as maize. We treated maize tissue culture with the demethylating agent 5-aza-2-deoxcytidine and examined long-term tissue culture lines to discover silenced transposable elements that have the potential to induce heritable genetic variation. Through these screens we have identified a novel low copy number hAT transposon, Tissue Culture Up-Regulated (TCUP, which is transcribed at high levels in long-term maize Black Mexican Sweet (BMS tissue culture and up-regulated in response to treatment with 5-aza-2-deoxycytidine. Analysis of the TIGR Maize Gene Index revealed that this element is the most frequently represented EST from the BMS cell culture library and is not represented in other tissue libraries, which is the basis for its name. A full-length sequence was assembled in inbred B73 that contains the putative functional motifs required for autonomous movement of a hAT transposon. Transposon display detected movement of TCUP in two long-term tissue cultured cell lines of the genotype Hi-II AxB and BMS. This research implicates TCUP as a transposon that is capable of reactivation and which may also be particularly sensitive to the stress of the tissue culture environment. Our findings are consistent with the hypothesis that epigenetic alterations potentiate genomic responses to stress during clonal propagation of plants.

  18. Imbalance between HAT and HDAC activities in the PBMCs of patients with ankylosing spondylitis or rheumatoid arthritis and influence of HDAC inhibitors on TNF alpha production.

    Directory of Open Access Journals (Sweden)

    Eric Toussirot

    Full Text Available OBJECTIVE: Acetylation or deacetylation of histone proteins may modulate cytokine gene transcription such as TNF alpha (TNF. We evaluated the balance between histone deacetytlase (HDAC and histone acetyltransferase (HAT in patients with rheumatoid arthritis (RA or ankylosing spondylitis (AS compared to healthy controls (HC and determined the influence of HDAC inhibitors (trichostatin A -TSA- or Sirtinol -Sirt- on these enzymatic activities and on the PBMC production of TNF. METHODS: 52 patients with RA, 21 with AS and 38 HC were evaluated. HAT and HDAC activities were measured on nuclear extracts from PBMC using colorimetric assays. Enzymatic activities were determined prior to and after ex vivo treatment of PBMC by TSA or Sirt. TNF levels were evaluated in PBMC culture supernatants in the absence or presence of TSA or Sirt. RESULTS: HAT and HDAC activities were significantly reduced in AS, while these activities reached similar levels in RA and HC. Ex vivo treatment of PBMC by HDACi tended to decrease HDAC expression in HC, but Sirt significantly reduced HAT in RA. TNF production by PBMC was significantly down-regulated by Sirt in HC and AS patients. CONCLUSION: HAT and HDAC were disturbed in AS while no major changes were found in RA. HDACi may modulate HDAC and HAT PBMC expression, especially Sirt in RA. Sirtinol was able to down regulate TNF production by PBMC in HC and AS. An imbalance between HAT and HDAC activities might provide the rationale for the development of HDACi in the therapeutic approach to inflammatory rheumatic diseases.

  19. Optimization of the Laser Hardening Process by Adapting the Intensity Distribution to Generate a Top-hat Temperature Distribution Using Freeform Optics

    Directory of Open Access Journals (Sweden)

    Fritz Klocke

    2017-06-01

    Full Text Available Laser hardening is a surface hardening process which enables high quality results due to the controllability of the energy input. The hardened area is determined by the heat distribution caused by the intensity profile of the laser beam. However, commonly used top-hat laser beams do not provide an ideal temperature profile. Therefore, in this paper the beam profile, and thus the temperature profile, is optimized using freeform optics. The intensity distribution is modified to generate a top-hat temperature profile on the surface. The results of laser hardening with the optimized distribution are thereupon compared with results using a top-hat intensity distribution.

  20. Structure of the Hat Creek graben region: Implications for the structure of the Hat Creek graben and transfer of right-lateral shear from the Walker Lane north of Lassen Peak, northern California, from gravity and magnetic anomalies

    Science.gov (United States)

    Langenheim, Victoria; Jachens, Robert C.; Clynne, Michael A.; Muffler, L. J. Patrick

    2016-01-01

    Interpretation of magnetic and new gravity data provides constraints on the geometry of the Hat Creek Fault, the amount of right-lateral offset in the area between Mt. Shasta and Lassen Peak, and confirmation of the influence of pre-existing structure on Quaternary faulting. Neogene volcanic rocks coincide with short-wavelength magnetic anomalies of both normal and reversed polarity, whereas a markedly smoother magnetic field occurs over the Klamath Mountains and its Paleogene cover. Although the magnetic field over the Neogene volcanic rocks is complex, the Hat Creek Fault, which is one of the most prominent normal faults in the region and forms the eastern margin of the Hat Creek Valley, is marked by the eastern edge of a north-trending magnetic and gravity high 20-30 km long. Modeling of these anomalies indicates that the fault is a steeply dipping (~75-85°) structure. The spatial relationship of the fault as modeled by the potential-field data, the youngest strand of the fault, and relocated seismicity suggests that deformation continues to step westward across the valley, consistent with a component of right-lateral slip in an extensional environment. Filtered aeromagnetic data highlight a concealed magnetic body of Mesozoic or older age north of Hat Creek Valley. The body’s northwest margin strikes northeast and is linear over a distance of ~40 km. Within the resolution of the aeromagnetic data (1-2 km), we discern no right-lateral offset of this body. Furthermore, Quaternary faults change strike or appear to end, as if to avoid this concealed magnetic body and to pass along its southeast edge, suggesting that pre-existing crustal structure influenced younger faulting, as previously proposed based on gravity data.

  1. A Damage Tolerance Comparison of Composite Hat-Stiffened and Honeycomb Sandwich Structure for Launch Vehicle Interstage Applications

    Science.gov (United States)

    Nettles, A. T.

    2011-01-01

    In this study, a direct comparison of the compression-after-impact (CAI) strength of impact-damaged, hat-stiffened and honeycomb sandwich structure for launch vehicle use was made. The specimens used consisted of small substructure designed to carry a line load of approx..3,000 lb/in. Damage was inflicted upon the specimens via drop weight impact. Infrared thermography was used to examine the extent of planar damage in the specimens. The specimens were prepared for compression testing to obtain residual compression strength versus damage severity curves. Results show that when weight of the structure is factored in, both types of structure had about the same CAI strength for a given damage level. The main difference was that the hat-stiffened specimens exhibited a multiphase failure whereas the honeycomb sandwich structure failed catastrophically.

  2. Finite element normal mode analysis of resistance welding jointed of dissimilar plate hat structure

    Science.gov (United States)

    Nazri, N. A.; Sani, M. S. M.

    2017-10-01

    Structural joints offer connection between structural element (beam, plate, solid etc.) in order to build a whole assembled structure. The complex behaviour of connecting elements plays a valuable role in characteristics of dynamic such as natural frequencies and mode shapes. In automotive structures, the trustworthiness arrangement of the structure extremely depends on joints. In this paper, top hat structure is modelled and designed with spot welding joint using dissimilar materials which is mild steel 1010 and stainless steel 304, using finite element software. Different types of connector elements such as rigid body element (RBE2), welding joint element (CWELD), and bar element (CBAR) are applied to represent real connection between two dissimilar plates. Normal mode analysis is simulated with different types of joining element in order to determine modal properties. Natural frequencies using RBE2, CBAR and CWELD are compared to equivalent rigid body method. Connection that gives the lowest percentage error among these three will be selected as the most reliable joining for resistance spot weld. From the analysis, it is shown that CWELD is better compared to others in term of weld joining among dissimilar plate materials. It is expected that joint modelling of finite element plays significant role in structural dynamics.

  3. Effects of metric hierarchy and rhyme predictability on word duration in The Cat in the Hat.

    Science.gov (United States)

    Breen, Mara

    2018-05-01

    Word durations convey many types of linguistic information, including intrinsic lexical features like length and frequency and contextual features like syntactic and semantic structure. The current study was designed to investigate whether hierarchical metric structure and rhyme predictability account for durational variation over and above other features in productions of a rhyming, metrically-regular children's book: The Cat in the Hat (Dr. Seuss, 1957). One-syllable word durations and inter-onset intervals were modeled as functions of segment number, lexical frequency, word class, syntactic structure, repetition, and font emphasis. Consistent with prior work, factors predicting longer word durations and inter-onset intervals included more phonemes, lower frequency, first mention, alignment with a syntactic boundary, and capitalization. A model parameter corresponding to metric grid height improved model fit of word durations and inter-onset intervals. Specifically, speakers realized five levels of metric hierarchy with inter-onset intervals such that interval duration increased linearly with increased height in the metric hierarchy. Conversely, speakers realized only three levels of metric hierarchy with word duration, demonstrating that they shortened the highly predictable rhyme resolutions. These results further understanding of the factors that affect spoken word duration, and demonstrate the myriad cues that children receive about linguistic structure from nursery rhymes. Copyright © 2018 Elsevier B.V. All rights reserved.

  4. Improvement and evaluation of polymer-matrix composite panels with hat stiffeners

    Directory of Open Access Journals (Sweden)

    Li S. J.

    2016-01-01

    Full Text Available Hat-stiffened composite panels fabricated by co-curing technologies are widely used in the fuselage panel due to the good structural stability and high efficiency of axial load transferring. The bonding capability between the stiffener and skin is a primary criterion to assess the co-curing quality. In this paper, two reinforcement technologies of filling filler in the triangle region and adding split-stopping tape between the stiffener and skin were employed to improve the bonding capability. Effect of filler and split-stopping tape on the interface strength was analyzed, and the optimal size range of the filler and split-stopping tape were obtained. To improve the universality of application for the two reinforcement techniques, the filling coefficient of 0.62~0.77 and the split-stopping tape width coefficient of 0.56~0.67 were obtained by calculation. Results of the study can be used to develop other kinds of stiffened panels and will ultimately lead to optimized skin/stiffener designs.

  5. Sampling of BTX in Hat Yai city using cost effective laboratory-built PCB passive sampler.

    Science.gov (United States)

    Subba, Jas Raj; Thammakhet, Chongdee; Thavarungkul, Panote; Kanatharana, Proespichaya

    2016-08-23

    A laboratory-built printed circuit board (PCB) passive sampler used for the monitoring of xylene and styrene in copy print shops was re-validated for detecting benzene, toluene and xylene (BTX) and applied for the sampling of ambient air from Hat Yai city, Songkhla, Thailand, in the month of November 2014. For monitoring, the PCB passive samplers were exposed to target analytes in 16 locations covering high to low exposure areas. After sampling, the samplers were thermally desorbed and the analytes were trapped by multi-walled carbon nanotubes packed into a micro-preconcentrator coupled to a gas chromatograph (GC) equipped with a flame ionization detector. At the optimum GC operating conditions, the linear dynamic ranges for BTX were 0.06-5.6 µg for benzene, 0.07-2.2 µg for toluene and 0.23-2.5 µg for xylene with R(2) > 0.99 with the limits of detection being 6.6, 6.8 and 19 ng for benzene, toluene and xylene, respectively. The concentrations of BTX in the 16 sampling sites were in the range of N.D.-1.3 ± 1.6, 4.50 ± 0.76-49.6 ± 3.7 and 1.00 ± 0.21-39.6 ± 3.1 µg m(-3), respectively. When compared to past studies, there had been an increase in the benzene concentration.

  6. Hospital Acquired Thrombosis (HAT) Prevention in an Acute Hospital; A Single Centre Cross-Sectional Study

    LENUS (Irish Health Repository)

    Khan, MI

    2017-04-01

    Evidence based guidelines are effective in reducing incidence of venous thromboembolism (VTE) which is associated with morbidly, mortality and economic burden. This study aimed to identify the proportion of inpatients who had a VTE risk assessment (RA) performed and who received thromboprophylaxis (TP), in Cork University Hospital. There was no structured RA tool at the time; information was obtained from medical and drug charts to ascertain if a RA was performed. Patients were then RA by researchers and stratified as per NICE guidelines and the proportion who received TP was calculated. One thousand and nineteen inpatients were screened. Risk was documented in 24% of cases. TP was prescribed in 43.2% of inpatients. Following application of a RA tool >80% were at high risk of VTE with low risk of bleeding with TP prescription in 46.3% of inpatients. A national collaborative effort should be encouraged to develop a standardized approach for safe RA of inpatients and prescription of TP for prevention of HAT

  7. Detection of microcalcification with top-hat transform and the Gibbs random fields.

    Science.gov (United States)

    Bharadwaj, Akshay S; Celenk, Mehmet

    2015-01-01

    Breast cancer is one of the most common causes of death in women aged 40 and above. Early detection of breast cancer has been one of the prime topics of research in biomedical engineering area. Micro-calcifications (MCs) are the indicators of early stages of breast cancer, and the detection of these MCs will, in turn, lead to diagnosis and treatment of breast cancer at its earliest stages. This paper proposes a new method to detect MCs in a digital mammogram. The approach starts with the segmentation of the digital mammogram to isolate the breast region, using fuzzy C means clustering algorithm. The segmented image is then further segmented using top-hat transform to localize the region of interest. A watershed transform is used to isolate the region of interest from rest of the image. The Gibbs random fields are employed to analyze the pixels in conjunction with the devised clique patterns and detect MCs in the image. A thresholding is performed on the processed image where the MCs are detected. The proposed algorithm is highly effective in reducing the region of interest to the region which has a high probability of finding a calcification or MC. It has an overall detection rate of 94.4% and accuracy of 88.2% with a false negative detection rate of 5.6%, respectively.

  8. Hats around the World. A Thematic Mini-Unit for Emergent Readers. Grades K-2 [and] Teaching Guide.

    Science.gov (United States)

    Charlesworth, Liza; Spann, Mary Beth

    This kit presents a 16-page child-sized book full of photographs and easy, predictable text; a read-along audiotape; and a teaching guide on the topic of hats from 12 different cultures. Although written for emergent readers, the book in the kit includes all the elements of a real book--title page, dedication, author photo, and an easy-to-read…

  9. HATS-36b and 24 Other Transiting/Eclipsing Systems from the HATSouth-K2 Campaign 7 Program

    Science.gov (United States)

    Bayliss, D.; Hartman, J. D.; Zhou, G.; Bakos, G. Á.; Vanderburg, A.; Bento, J.; Mancini, L.; Ciceri, S.; Brahm, R.; Jordán, A.; Espinoza, N.; Rabus, M.; Tan, T. G.; Penev, K.; Bhatti, W.; de Val-Borro, M.; Suc, V.; Csubry, Z.; Henning, Th.; Sarkis, P.; Lázár, J.; Papp, I.; Sári, P.

    2018-03-01

    We report on the result of a campaign to monitor 25 HATSouth candidates using the Kepler space telescope during Campaign 7 of the K2 mission. We discover HATS-36b (EPIC 215969174b, K2-145b), an eccentric (e=0.105+/- 0.028) hot Jupiter with a mass of 3.216+/- 0.062 {M}{{J}} and a radius of 1.235+/- 0.043 {R}{{J}}, which transits a solar-type G0V star (V = 14.386) in a 4.1752-day period. We also refine the properties of three previously discovered HATSouth transiting planets (HATS-9b, HATS-11b, and HATS-12b) and search the K2 data for TTVs and additional transiting planets in these systems. In addition, we also report on a further three systems that remain as Jupiter-radius transiting exoplanet candidates. These candidates do not have determined masses, however pass all of our other vetting observations. Finally, we report on the 18 candidates that we are now able to classify as eclipsing binary or blended eclipsing binary systems based on a combination of the HATSouth data, the K2 data, and follow-up ground-based photometry and spectroscopy. These range in periods from 0.7 day to 16.7 days, and down to 1.5 mmag in eclipse depths. Our results show the power of combining ground-based imaging and spectroscopy with higher precision space-based photometry, and serve as an illustration as to what will be possible when combining ground-based observations with TESS data.

  10. Ideologiekritik des E-Learnings. Welchen Nutzen hat die Einführung von E-Learning?

    Directory of Open Access Journals (Sweden)

    Katharina Kaiser-Müller

    2015-03-01

    Full Text Available Vor etwa sieben Jahren hat das damalige Bundesministerium für Unterricht, Kunst und Kultur (bm:ukk, das seit 2014 Bundesministerium für Bildung und Frauen (BMBF genannt wird, verschiedene Maßnahmen im Blick auf neuen Medien – insbesondere im Blick auf das E-Learning – gesetzt, um einen Beitrag zur Vorbereitung der Lernenden auf eine Informations- und Wissensgesellschaft zu leisten. E-Learning wurde als Erfolgsfaktor für die Zukunft gesehen und mit der Begründung, es fördere das individuelle und selbst gesteuerte Lernen, gefördert. Die zentrale Frage ist dabei: Welchen Nutzen hat die Einführung von E-Learning? In diesem Artikel wird dahingehend aufgezeigt, dass E-Learning nicht wegen pädagogischem Bedarf, sondern durch ministeriell gesetzte Maßnahmen eingeführt wurde und dadurch – wenn auch nicht bewusst und schon gar nicht als solches kommuniziert – neoliberale Strukturen durchgesetzt wurden. Die Einführung von E-Learning hat somit für deren Akzeptanz gesorgt.

  11. TASTE IV: Refining ephemeris and orbital parameters for HAT-P-20b and WASP-1b

    Science.gov (United States)

    Granata, V.; Nascimbeni, V.; Piotto, G.; Bedin, L. R.; Borsato, L.; Cunial, A.; Damasso, M.; Malavolta , L.

    2014-10-01

    We present four new light curves of the transiting exoplanets WASP-1b and HAT-P-20b, observed within the TASTE ({The Asiago Search for Transit timing variations of Exoplanets}) project. We re-analyzed light curves from the literature in a homogeneous way, calculating a refined ephemeris and orbital-physical parameters for both objects. WASP-1b does not show any significant Transit Timing Variation signal at the 120 s level. As for HAT-P-20b, we detected a deviation from our re-estimated linear ephemeris that could be ascribed to the presence of a perturber or, more probably, to a previously unnoticed high level of stellar activity. The rotational period of HAT-P-20 A that we obtained from archival data ({P_rot≃ 14.5} d), combined with its optical variability and strong emission of Ca II H & K lines, is consistent with a young stellar age ({< 1} Gyr) and support the hypothesis that stellar activity may be responsible of the measured deviations of the transit times.

  12. The Queensland fruit fly, Bactrocera tryoni, contains multiple members of the hAT family of transposable elements.

    Science.gov (United States)

    Pinkerton, A C; Whyard, S; Mende, H A; Coates, C J; O'Brochta, D A; Atkinson, P W

    1999-11-01

    Members of the hAT transposable element family are mobile in non-host insect species and have been used as transformation vectors in some of these species. We report that the Queensland fruit fly, Bactrocera tryoni, contains at least two types of insect hAT elements called Homer and a Homer-like element (HLE). The Homer element is 3789 bp in size and contains 12-bp imperfect inverted terminal repeats. The Homer element contains a long open reading frame (ORF) that encodes a putative transposase. Three different copies of this long ORF were recovered from the B. tryoni genome and, upon transcription and translation in an in vitro system, all produced transposase. The HLE is an incomplete element since no 3' inverted terminal repeat (ITR) was found. Homer and the HLE are as related to one another as either is to the other insect hAT elements such as Hermes, hobo, hermit and hopper. The structure and distribution of these two Homer elements is described.

  13. The acetyltransferase HAT1 moderates the NF-κB response by regulating the transcription factor PLZF.

    Science.gov (United States)

    Sadler, Anthony J; Suliman, Bandar A; Yu, Liang; Yuan, Xiangliang; Wang, Die; Irving, Aaron T; Sarvestani, Soroush T; Banerjee, Ashish; Mansell, Ashley S; Liu, Jun-Ping; Gerondakis, Steve; Williams, Bryan R G; Xu, Dakang

    2015-04-13

    To date, the activities of protein kinases have formed the core of our understanding of cell signal transduction. Comprehension of the extent of protein acetylation has raised expectations that this alternate post-transcriptional modification will be shown to rival phosphorylation in its importance in mediating cellular responses. However, limited instances have been identified. Here we show that signalling from Toll-like or TNF-α receptors triggers the calcium/calmodulin-dependent protein kinase (CaMK2) to activate histone acetyltransferase-1 (HAT1), which then acetylates the transcriptional regulator PLZF. Acetylation of PLZF promotes the assembly of a repressor complex incorporating HDAC3 and the NF-κB p50 subunit that limits the NF-κB response. Accordingly, diminishing the activity of CaMK2, the expression levels of PLZF or HAT1, or mutating key residues that are covalently modified in PLZF and HAT1, curtails control of the production of inflammatory cytokines. These results identify a central role for acetylation in controlling the inflammatory NF-κB transcriptional programme.

  14. Sanitation conditions of clean food good taste restaurants in Hat Yai City Municipality

    Directory of Open Access Journals (Sweden)

    Sopon, A.

    2004-01-01

    Full Text Available Sanitation conditions and microbiological quality of 52 “Clean Food Good Taste” restaurants in Hat Yai city municipality were examined using a standard food sanitation survey checklist based on the Department of Health and Department of Medical Science, Ministry of Public Health. Coliform bacteria and Escherichia coli (E. coli were investigated in samples of foods and drinking water, whereas total bacterial count (TBC was carried out in samples of foods, plates, spoons, glasses and food handlers. The methods of investigation were the Most Probable Number (MPN method for coliform bacteria, E. coli and the standard plate count method for TBC. The SI-2 field test kit was used to indicate microbiological contamination, particularly coliform bacteria. It was found that 38/52 (73.1% restaurants passed all items of food sanitation standard. The food sanitation condition with the lowest number passing was the dressing of food handlers (45/52, 86.5% followed by the area for eating, preparing and cooking (47/52, 90.4%. Microbiological quality of food samples based on both MPN of coliform bacteria and E. coli was at an acceptable level in 190/202 samples (94.1%. However, in samples of drinking water only 19/52 (36.5% passed the MPN standard for coliform bacteria and 45/52 (86.5% that for E. coli. Moreover, among the 52 restaurants, the numbers (percentages passing the standard TBC in samples of plate, spoon, glass, cooker handlers and server handlers were 32 (61.5%, 27(51.9%, 20 (38.5%, 2 (3.9% and 1 (1.9%, respectively. Comparison of microbiological quality between the SI-2 test kit and MPN coliform/TBC showed no significant differences for samples of foods, but significant differences for the rest of the samples (p<0.05, t-test.

  15. Groundwater evolution beneath Hat Yai, a rapidly developing city in Thailand

    Science.gov (United States)

    Lawrence, A. R.; Gooddy, D. C.; Kanatharana, P.; Meesilp, W.; Ramnarong, V.

    2000-09-01

    Many cities and towns in South and Southeast Asia are unsewered, and urban wastewaters are often discharged either directly to the ground or to surface-water canals and channels. This practice can result in widespread contamination of the shallow groundwater. In Hat Yai, southern Thailand, seepage of urban wastewaters has produced substantial deterioration in the quality of the shallow groundwater directly beneath the city. For this reason, the majority of the potable water supply is obtained from groundwater in deeper semi-confined aquifers 30-50 m below the surface. However, downward leakage of shallow groundwater from beneath the city is a significant component of recharge to the deeper aquifer, which has long-term implications for water quality. Results from cored boreholes and shallow nested piezometers are presented. The combination of high organic content of the urban recharge and the shallow depth to the water table has produced strongly reducing conditions in the upper layer and the mobilisation of arsenic. A simple analytical model shows that time scales for downward leakage, from the surface through the upper aquitard to the semi-confined aquifer, are of the order of several decades. Résumé. De nombreuses villes du sud et du sud-est de l'Asie ne possèdent pas de réseaux d'égouts et les eaux usées domestiques s'écoulent souvent directement sur le sol ou dans des canaux et des cours d'eau de surface. Ces pratiques peuvent provoquer une contamination dispersée de la nappe phréatique. A Hat Yai (sud de la Thaïlande), les infiltrations d'eaux usées domestiques sont responsables d'une détérioration notable de la qualité de la nappe phréatique directement sous la ville. Pour cette raison, la majorité de l'eau potable est prélevée dans des aquifères semi-captifs plus profonds, situés entre 30 et 50 m sous la surface. Cependant, une drainance à partir de la nappe phréatique sous la ville constitue une composante significative de la recharge

  16. Possible detection of a bimodal cloud distribution in the atmosphere of HAT-P-32 A b from multiband photometry

    Science.gov (United States)

    Tregloan-Reed, J.; Southworth, J.; Mancini, L.; Mollière, P.; Ciceri, S.; Bruni, I.; Ricci, D.; Ayala-Loera, C.; Henning, T.

    2018-03-01

    We present high-precision photometry of eight separate transit events in the HAT-P-32 planetary system. One transit event was observed simultaneously by two telescopes of which one obtained a simultaneous multiband light curve in three optical bands, giving a total of 11 transit light curves. Due to the filter selection and in conjunction with using the defocused photometry technique, we were able to obtain an extremely high-precision, ground-based transit in the u band (350 nm), with an rms scatter of ≈1 mmag. All 11 transits were modelled using PRISM and GEMC, and the physical properties of the system calculated. We find the mass and radius of the host star to be 1.182 ± 0.041 M⊙ and 1.225 ± 0.015 R⊙, respectively. For the planet, we find a mass of 0.80 ± 0.14 MJup, a radius of 1.807 ± 0.022 RJup, and a density of 0.126 ± 0.023 ρJup. These values are consistent with those found in the literature. We also obtain a new orbital ephemeris for the system T0 = BJD/TDB 2 454 420.447187(96) + 2.15000800(10) × E. We measured the transmission spectrum of HAT-P-32 A b and compared it to theoretical transmission spectra. Our results indicate a bimodal cloud particle distribution consisting of Rayleigh-like haze and grey absorbing cloud particles within the atmosphere of HAT-P-32 A b.

  17. Treatment efficiency in wastewater treatment plant of Hat Yai Municipality by quantitative removal of microbial indicators

    Directory of Open Access Journals (Sweden)

    Duangporn Kantachote

    2009-11-01

    Full Text Available The efficiency of treatment in a wastewater treatment plant of Hat Yai Municipality through stabilization ponds and constructed wetlands was monitored by using the bacterial indicators, total coliforms (TC, fecal coliforms (FC, Escherichia coli and fecal streptococci (FS, and photosynthetic microbes. The sequence of water flow in the wastewater treatment plant is as follows: primary or anaerobic pond (P, facultative pond (F, maturation pond (M, constructed wetlands (W1, W2 and W3, and an effluent storage pond (S for the treated wastewater. The wastewater treatment plant has an approximate area of 3,264,000 m2 (2,040 rai and its dry weather flow was running at only 40,000 m3/ day. There were 10 sampling times used for all the 7 ponds during July-October, 2006.Statistical analysis using a Two-Factorial Design model, indicated that pond types significantly affected temperature, dissolved oxygen (DO, and pH (p<0.05, whereas the time of sampling during the day had a significant effect (p<0.05 only on the temperature and light intensity available to the ponds. There were also significant different removal efficiencies of the different bacterial indicator groups tested (p<0.05. The overall performance of the wastewater treatment plant effectively removed TC, FC, E. coli, and FS as follows, 99.8%, 99.8%, 75.8% and 98.8%, respectively. The amounts of bacterial indicators, except for E. coli, showed a negative correlation with levels of light intensity and DO, whereas there was no correlation between the pH and the different indicator bacteria. There was a positive middle level correlation between pHand chlorophyll a.There were five different divisions of photosynthetic organisms detected throughout the plant as follows, Cyanophyta, Chlorophyta, Bacillariophyta, Euglenophyta, and Pyrrhophyta. The least diversity was found in the anaerobic pond (P as there were only 15 genera. Euglena, an indicator of dirty water, was detected only in this pond. The

  18. Point source detection using the Spherical Mexican Hat Wavelet on simulated all-sky Planck maps

    Science.gov (United States)

    Vielva, P.; Martínez-González, E.; Gallegos, J. E.; Toffolatti, L.; Sanz, J. L.

    2003-09-01

    We present an estimation of the point source (PS) catalogue that could be extracted from the forthcoming ESA Planck mission data. We have applied the Spherical Mexican Hat Wavelet (SMHW) to simulated all-sky maps that include cosmic microwave background (CMB), Galactic emission (thermal dust, free-free and synchrotron), thermal Sunyaev-Zel'dovich effect and PS emission, as well as instrumental white noise. This work is an extension of the one presented in Vielva et al. We have developed an algorithm focused on a fast local optimal scale determination, that is crucial to achieve a PS catalogue with a large number of detections and a low flux limit. An important effort has been also done to reduce the CPU time processor for spherical harmonic transformation, in order to perform the PS detection in a reasonable time. The presented algorithm is able to provide a PS catalogue above fluxes: 0.48 Jy (857 GHz), 0.49 Jy (545 GHz), 0.18 Jy (353 GHz), 0.12 Jy (217 GHz), 0.13 Jy (143 GHz), 0.16 Jy (100 GHz HFI), 0.19 Jy (100 GHz LFI), 0.24 Jy (70 GHz), 0.25 Jy (44 GHz) and 0.23 Jy (30 GHz). We detect around 27 700 PS at the highest frequency Planck channel and 2900 at the 30-GHz one. The completeness level are: 70 per cent (857 GHz), 75 per cent (545 GHz), 70 per cent (353 GHz), 80 per cent (217 GHz), 90 per cent (143 GHz), 85 per cent (100 GHz HFI), 80 per cent (100 GHz LFI), 80 per cent (70 GHz), 85 per cent (44 GHz) and 80 per cent (30 GHz). In addition, we can find several PS at different channels, allowing the study of the spectral behaviour and the physical processes acting on them. We also present the basic procedure to apply the method in maps convolved with asymmetric beams. The algorithm takes ~72 h for the most CPU time-demanding channel (857 GHz) in a Compaq HPC320 (Alpha EV68 1-GHz processor) and requires 4 GB of RAM memory; the CPU time goes as O[NRoN3/2pix log(Npix)], where Npix is the number of pixels in the map and NRo is the number of optimal scales needed.

  19. Assessment of efficiency of water supply system in Prince of Songkla University, Hat Yai Campus

    Directory of Open Access Journals (Sweden)

    Chaivisit, P.

    2007-03-01

    Full Text Available Assessment of efficiency of water production system in Prince of Songkla University, Hat Yai Campus, was conducted in this study. Topics covered include 1 quality and quantity of raw water, 2 water productionprocess, 3 management and maintenance of water production system, and 4 quality of finished water. Totally, 494 water samples were collected during the study. All water samples were analyzed for turbidity,pH, temperature, conductivity, TDS, total coliforms, fecal coliforms and residual chlorine. In addition to the mentioned parameters, 30 of these water samples were also analyzed for hardness, chloride, nitratenitrogen,sulfate and heavy metals (manganese, copper, zinc, iron, chromium, cadmium, lead and mercury. All water samples were collected during November, 2004 (rainy season and March, 2005 (summer season.It was found that the quality of the water in the Sritrang reservoir fell into Class 2 of Thailand Surface Water Quality Standard that requires ordinary water treatment processes prior to consumptions.Cadmium, lead and mercury were not detected by Inductively Coupled Plasma (ICP method. There are 2 sets of water production system. The first set consists of 4 pressure filters which could reduce turbidity atvarying efficiencies: 33.83%, 18.26%, 42.76% and 65.67% depending mainly on the extent of chemical dosing control and the maintenance of the filter media. Another system employed sedimentation tank andrapid sand filter, which could remove turbidity at 89.28%. When combined finished water from both systems were analyzed, it was found that removals of manganese, copper, zinc, iron and chromium were 42.65%,30.02%, 19.54%, 56.82% and 15.12%, respectively. Residual chlorine concentration of the finished water was not more than 0.2 mg/L and no total coliforms or fecal coliforms were detected. The plant had sufficientand competent personnel to carry out their normal tasks but occasional negligence and lack of specific water testing or

  20. Characterizing Giant Exoplanets through Multiwavelength Transit Observations: HAT-P-14 b & TrES-1 b

    Science.gov (United States)

    Rivera, Daniel Ivan; Cole, Jackson Lane; Gardner, Cristilyn N.; Garver, Bethany Ray; Jarka, Kyla L.; Kar, Aman; McGough, Aylin Marie; PeQueen, David Jeffrey; Kasper, David; Jang-Condell, Hannah; Kobulnicky, Henry; Dale, Daniel

    2018-01-01

    Much current work focuses on characterizing exoplanets. We observed several known exoplanets using the 2.3 meter Wyoming Infrared Observatory over the course of ten weeks using the ugriz Sloan filters. Our goal was to quantify planet-to-star radius ratio, a ratio that is potentially wavelength dependent due to exoplanet atmospherics. We present the results for exoplanets HAT-P 14 b and TrES-1 b. Complementary data from the literature are utilized to supplement our analysis. This work is supported by the National Science Foundation under REU grant AST 1560461 and PAARE grant AST 1559559.

  1. Diversity of higher marine fungi at Hat Khanom-Mu Ko Thale Tai National Park, Southern Thailand

    Directory of Open Access Journals (Sweden)

    Jariya Sakayaroj

    2011-02-01

    Full Text Available Species occurrence and distribution of higher marine fungi at Hat Khanom-Mu Ko Thale Tai National Park, Nakhon SiThammarat Province, Southern Thailand was investigated. Four collections from four sites yielded 112 higher marine fungirepresenting 79 ascomycetes, 3 basidiomycetes, 30 anamorphic fungi, while others await further identification. Average percentageoccurrence of fungi recorded ranged from 0.05-11.3%. Species diversity, richness, and evenness were greatest atSite IV, Ao Tok, Koh Taen. The most frequently encountered taxa for all sites (>10% were Corollospora maritima andLindra thallasiae. Lindra thallasiae and Swampomyces aegyptiacus were recorded for the first time in Thailand.

  2. A novel hAT element in Bombyx mori and Rhodnius prolixus: its relationship with miniature inverted repeat transposable elements (MITEs) and horizontal transfer.

    Science.gov (United States)

    Zhang, H-H; Shen, Y-H; Xu, H-E; Liang, H-Y; Han, M-J; Zhang, Z

    2013-10-01

    Comparative analysis of transposable elements (TEs) from different species can make it possible to reconstruct their history over evolutionary time. In this study, we identified a novel hAT element in Bombyx mori and Rhodnius prolixus with characteristic GGGCGGCA repeats in its subterminal region. Meanwhile, phylogenetic analysis demonstrated that the elements in these two species might represent a separate cluster of the hAT superfamily. Strikingly, a previously identified miniature inverted repeat transposable element (MITE) shared high identity with this autonomous element across the entire length, supporting the hypothesis that MITEs are derived from the internal deletion of DNA transposons. Interestingly, identity of the consensus sequences of this novel hAT element between B. mori and R. prolixus, which diverged about 370 million years ago, was as high as 96.5% over their full length (about 3.6 kb) at the nucleotide level. The patchy distribution amongst species, coupled with overall lack of intense purifying selection acting on this element, suggest that this novel hAT element might have experienced horizontal transfer between the ancestors of B. mori and R. prolixus. Our results highlight that this novel hAT element could be used as a potential tool for germline transformation of R. prolixus to control the transmission of Trypanosoma cruzi, which causes Chagas disease. © 2013 Royal Entomological Society.

  3. ANALYSIS OF SPIN-ORBIT ALIGNMENT IN THE WASP-32, WASP-38, AND HAT-P-27/WASP-40 SYSTEMS

    Energy Technology Data Exchange (ETDEWEB)

    Brown, D. J. A.; Collier Cameron, A.; Enoch, B.; Miller, G. R. M. [SUPA, School of Physics and Astronomy, University of St Andrews, North Haugh, St Andrews, Fife KY16 9SS (United Kingdom); Diaz, R. F. [LAM (Laboratoire d' Astrophysique de Marseille), Aix Marseille Universite, CNRS, UMR 7326, F-13388 Marseille (France); Doyle, A. P.; Smalley, B.; Anderson, D. R.; Hellier, C.; Maxted, P. F. L. [Astrophysics Group, School of Physical and Geographical Sciences, Lennard-Jones Building, Keele University, Staffordshire ST5 5BG (United Kingdom); Gillon, M. [Institut d' Astrophysique et de Geophysique, Universite de Liege, Allee du 6 Aout, 17 (Bat. B5C) Sart Tilman, B-4000 Liege (Belgium); Lendl, M.; Triaud, A. H. M. J.; Queloz, D. [Observatoire Astronomique de l' Universite de Geneve, 51 Chemin des Maillettes, CH-1290 Sauverny (Switzerland); Pollacco, D. [Astrophysics Research Centre, School of Mathematics and Physics, Queen' s University, University Road, Belfast BT7 1NN (United Kingdom); Boisse, I. [Centro de Astrofisica, Universidade do Porto, Rua das Estrelas, 4150-762 Porto (Portugal); Hebrard, G., E-mail: djab@st-andrews.ac.uk [Institut dAstrophysique de Paris, UMR7095 CNRS, Universite Pierre and Marie Curie, 98bis boulevard Arago, F-75014 Paris (France)

    2012-12-01

    We present measurements of the spin-orbit alignment angle, {lambda}, for the hot Jupiter systems WASP-32, WASP-38, and HAT-P-27/WASP-40, based on data obtained using the HARPS spectrograph. We analyze the Rossiter-McLaughlin effect for all three systems and also carry out Doppler tomography for WASP-32 and WASP-38. We find that WASP-32 (T {sub eff} = 6140{sup +90} {sub -100} K) is aligned, with an alignment angle of {lambda} = 10.{sup 0}5{sup +6.4} {sub -6.5} obtained through tomography, and that WASP-38 (T {sub eff} = 6180{sup +40} {sub -60} K) is also aligned, with tomographic analysis yielding {lambda} = 7.{sup 0}5{sup +4.7} {sub -6.1}. The latter result provides an order-of-magnitude improvement in the uncertainty in {lambda} compared to the previous analysis of Simpson et al. We are only able to loosely constrain the angle for HAT-P-27/WASP-40 (T{sub eff} = 5190{sup +160} {sub -170} K) to {lambda} = 24.{sup 0}2{sup +76.0}{sub -44.5}, owing to the poor signal-to-noise ratio of our data. We consider this result a non-detection under a slightly updated version of the alignment test of Brown et al. We place our results in the context of the full sample of spin-orbit alignment measurements, finding that they provide further support for previously established trends.

  4. Structural basis of hAT transposon end recognition by Hermes, an octameric DNA transposase from Musca domestica.

    Science.gov (United States)

    Hickman, Alison B; Ewis, Hosam E; Li, Xianghong; Knapp, Joshua A; Laver, Thomas; Doss, Anna-Louise; Tolun, Gökhan; Steven, Alasdair C; Grishaev, Alexander; Bax, Ad; Atkinson, Peter W; Craig, Nancy L; Dyda, Fred

    2014-07-17

    Hermes is a member of the hAT transposon superfamily that has active representatives, including McClintock's archetypal Ac mobile genetic element, in many eukaryotic species. The crystal structure of the Hermes transposase-DNA complex reveals that Hermes forms an octameric ring organized as a tetramer of dimers. Although isolated dimers are active in vitro for all the chemical steps of transposition, only octamers are active in vivo. The octamer can provide not only multiple specific DNA-binding domains to recognize repeated subterminal sequences within the transposon ends, which are important for activity, but also multiple nonspecific DNA binding surfaces for target capture. The unusual assembly explains the basis of bipartite DNA recognition at hAT transposon ends, provides a rationale for transposon end asymmetry, and suggests how the avidity provided by multiple sites of interaction could allow a transposase to locate its transposon ends amidst a sea of chromosomal DNA. Copyright © 2014 Elsevier Inc. All rights reserved.

  5. A SEARCH FOR WATER IN THE ATMOSPHERE OF HAT-P-26b USING LDSS-3C

    Energy Technology Data Exchange (ETDEWEB)

    Stevenson, Kevin B.; Bean, Jacob L.; Seifahrt, Andreas; Gilbert, Gregory J. [Department of Astronomy and Astrophysics, University of Chicago, 5640 S Ellis Avenue, Chicago, IL 60637 (United States); Line, Michael R. [NASA Ames Research Center, Moffett Field, CA 94035 (United States); Désert, Jean-Michel [Anton Pannekoek Institute for Astronomy, University of Amsterdam, Amsterdam (Netherlands); Fortney, Jonathan J., E-mail: kbs@uchicago.edu [Department of Astronomy and Astrophysics, University of California, Santa Cruz, CA 95064 (United States)

    2016-02-01

    The characterization of a physically diverse set of transiting exoplanets is an important and necessary step toward establishing the physical properties linked to the production of obscuring clouds or hazes. It is those planets with identifiable spectroscopic features that can most effectively enhance our understanding of atmospheric chemistry and metallicity. The newly commissioned LDSS-3C instrument on Magellan provides enhanced sensitivity and suppressed fringing in the red optical, thus advancing the search for the spectroscopic signature of water in exoplanetary atmospheres from the ground. Using data acquired by LDSS-3C and the Spitzer Space Telescope, we search for evidence of water vapor in the transmission spectrum of the Neptune-mass planet HAT-P-26b. Our measured spectrum is best explained by the presence of water vapor, a lack of potassium, and either a high-metallicity, cloud-free atmosphere or a solar-metallicity atmosphere with a cloud deck at ∼10 mbar. The emergence of multi-scale-height spectral features in our data suggests that future observations at higher precision could break this degeneracy and reveal the planet’s atmospheric chemical abundances. We also update HAT-P-26b’s transit ephemeris, t{sub 0} = 2455304.65218(25) BJD{sub TDB}, and orbital period, p = 4.2345023(7) days.

  6. An Algorithm of Building Extraction in Urban Area Based on Improved Top-hat Transformations and LBP Elevation Texture

    Directory of Open Access Journals (Sweden)

    HE Manyun

    2017-09-01

    Full Text Available Classification of building and vegetation is difficult solely by LiDAR data and vegetation in shadows can't be eliminated only by aerial images. The improved top-hat transformations and local binary patterns (LBP elevation texture analysis for building extraction are proposed based on the fusion of aerial images and LiDAR data. Firstly, LiDAR data is reorganized into grid cell, the algorithm removes ground points through top-hat transform. Then, the vegetation points are extracted by normalized difference vegetation index (NDVI. Thirdly, according to the elevation information of LiDAR points, LBP elevation texture is calculated and achieving precise elimination of vegetation in shadows or surrounding to the buildings. At last, morphological operations are used to fill the holes of building roofs, and region growing for complete building edges. The simulation is based on the complex urban area in Vaihingen benchmark provided by ISPRS, the results show that the algorithm affording higher classification accuracy.

  7. Importance of energy and angular resolutions in top-hat electrostatic analysers for solar wind proton measurements

    Science.gov (United States)

    De Marco, R.; Marcucci, M. F.; Bruno, R.; D'Amicis, R.; Servidio, S.; Valentini, F.; Lavraud, B.; Louarn, P.; Salatti, M.

    2016-08-01

    We use a numerical code which reproduces the angular/energy response of a typical top-hat electrostatic analyser starting from solar wind proton velocity distribution functions (VDFs) generated by numerical simulations. The simulations are based on the Hybrid Vlasov-Maxwell numerical algorithm which integrates the Vlasov equation for the ion distribution function, while the electrons are treated as a fluid. A virtual satellite launched through the simulation box measures the particle VDFs. Such VDFs are moved from the simulation Cartesian grid to energy-angular coordinates to mimic the response of a real sensor in the solar wind. Different energy-angular resolutions of the analyser are investigated in order to understand the influence of the phase-space resolution in existing and upcoming space missions, with regards to determining the key parameters of plasma dynamics.

  8. Convolutional Neural Networks with Batch Normalization for Classifying Hi-hat, Snare, and Bass Percussion Sound Samples

    DEFF Research Database (Denmark)

    Gajhede, Nicolai; Beck, Oliver; Purwins, Hendrik

    2016-01-01

    After having revolutionized image and speech processing, convolu- tional neural networks (CNN) are now starting to become more and more successful in music information retrieval as well. We compare four CNN types for classifying a dataset of more than 3000 acoustic and synthesized samples...... of the most prominent drum set instru- ments (bass, snare, hi-hat). We use the Mel scale log magnitudes (MLS) as a representation for the input of the CNN. We compare the classification results of 1) a CNN (3 conv/max-pool layers and 2 fully connected layers) without drop-out and batch normalization vs. three...... variants, 2) with drop-out, 3) with batch normalization (BN), and 4) with both drop-out and BN. The CNNs with BN yield the best classification results (97% accuracy)....

  9. Comments on the paper "The Mexican Hat Wavelet Family. Application to point source detection in CMB maps" by J. Gonzalez-Nuevo et al. (astro-ph/0604376)

    OpenAIRE

    Vio, Roberto; Andreani, Paola

    2006-01-01

    The arguments presented by Gonzalez-Nuevo et. al (2006) in favour of the Mexican Hat Wavelet Family (MHWF) are critically discussed here. These authors allege the optimal properties of this new class of filters in the detection of point sources embedded in a noise background but their claim is not based upon a solid mathematical foundation and proof.

  10. The Effect of the Six Hats Based on Program in the Development of the Pivotal Thinking of Islamic Concepts Students in Hussein University

    Science.gov (United States)

    Alkhateeb, Omar Salem

    2015-01-01

    This study aimed to detect the effect based on the strategies of the six hats in the development of the pivotal thinking on the achievement of the Al-Hussein University students Islamic concepts of the program has reached the study sample (216) students, were divided randomly into two groups: an experimental group of (108) students and consisted…

  11. Scanner deflection of top-hat converted single-mode lasers for cost-effective micro-machining at highest quality

    Science.gov (United States)

    Guetlich, B.; Mitra, T.; Toennissen, F.; Homburg, O.; Aschke, L.

    2009-02-01

    Direct laser patterning of various materials is today widely used in several micro-system production lines like inkjet printing, solar cell technology, flat-panel display production and medicine. Typically single-mode solid state lasers and their higher harmonics are used especially for machining of holes and grooves. The most prominent lasers are pulsed Nd:YAG lasers and their harmonics @ 266, 355 and 532 nm. Recently, the striking advantages of flat top intensity distributions for the efficiency and quality of these processes were demonstrated. The use of LIMO's compact Gaussian-to- top-hat converter enables the creation of steeper and sharper edges. Additionally, the higher energy efficiency of rectangular top hat profiles compared to smooth, circular Gaussian shapes allows for faster patterning. A standard method to reduce process times is the use of optical scanning systems. Yet, the application of Gaussian-to-top-hat converters in combination with a scanner was hindered by distortions of the top hat introduced by the F-Theta focussing lens of the scanners even at very small deflection angles (solar panels.

  12. Transiting Exoplanet Monitoring Project (TEMP). II. Refined System Parameters and Transit Timing Analysis of HAT-P-33b

    Science.gov (United States)

    Wang, Yong-Hao; Wang, Songhu; Liu, Hui-Gen; Hinse, Tobias C.; Laughlin, Gregory; Wu, Dong-Hong; Zhang, Xiaojia; Zhou, Xu; Wu, Zhenyu; Zhou, Ji-Lin; Wittenmyer, R. A.; Eastman, Jason; Zhang, Hui; Hori, Yasunori; Narita, Norio; Chen, Yuanyuan; Ma, Jun; Peng, Xiyan; Zhang, Tian-Meng; Zou, Hu; Nie, Jun-Dan; Zhou, Zhi-Min

    2017-08-01

    We present 10 R-band photometric observations of eight different transits of the hot Jupiter HAT-P-33b, which has been targeted by our Transiting Exoplanet Monitoring Project. The data were obtained by two telescopes at the Xinglong Station of National Astronomical Observatories of China (NAOC) from 2013 December through 2016 January, and exhibit photometric scatter of 1.6{--}3.0 {mmag}. After jointly analyzing the previously published photometric data, radial-velocity (RV) measurements, and our new light curves, we revisit the system parameters and orbital ephemeris for the HAT-P-33b system. Our results are consistent with the published values except for the planet to star radius ratio ({R}{{P}}/{R}* ), the ingress/egress duration (τ) and the total duration (T 14), which together indicate a slightly shallower and shorter transit shape. Our results are based on more complete light curves, whereas the previously published work had only one complete transit light curve. No significant anomalies in Transit Timing Variations (TTVs) are found, and we place upper mass limits on potential perturbers, largely supplanting the loose constraints provided by the extant RV data. The TTV limits are stronger near mean-motion resonances, especially for the low-order commensurabilities. We can exclude the existence of a perturber with mass larger than 0.6, 0.3, 0.5, 0.5, and 0.3 {M}\\oplus near the 1:3, 1:2, 2:3, 3:2, and 2:1 resonances, respectively.

  13. En hat er vel en hat ... eller?

    DEFF Research Database (Denmark)

    Bøilerehauge, Dorrit

    2007-01-01

    Mens vi kører i høj fart på "the information highway" - i den helt store bus midt på vejen - glemmer vi ofte noget meget vigtigt i vores glæde over, at verden tilsyneladende åbner sig for os, og vi kan kommunikere med hele verden med ét klik. Vi glemmer, at selvom trafikskilte som oftest er ens -...

  14. Radiological audit of remedial action activities at the processing sites Mexican Hat, Utah and Monument Valley, Arizona. Audit date: May 3--7, 1993, Final report

    International Nuclear Information System (INIS)

    1993-05-01

    The Uranium Mill Tailings Remedial Action (UMTRA) Project's Technical Assistance Contractor (TAC) performed a radiological audit of the Remedial Action Contractor (RAC), MK-Ferguson and CWM Federal Environmental Services, Inc., at the processing sites in Mexican Hat, Utah, and Monument Valley, Arizona. This audit was conducted May 3--7, 1993, by Bill James and Gerry Simiele of the TAC. Three site-specific findings and four observations were identified during the audit and are presented in this report. The overall conclusion from the audit is that the majority of the radiological aspects of the Mexican Hat, Utah, and Monument Valley, Arizona, remedial action programs are performed adequately. However, the findings identify that there is some inconsistency in following procedures and meeting requirements for contamination control, and a lack of communication between the RAC and the DOE on variances from the published remedial action plan (RAP)

  15. Two hAT transposon genes were transferred from Brassicaceae to broomrapes and are actively expressed in some recipients

    Science.gov (United States)

    Sun, Ting; Renner, Susanne S.; Xu, Yuxing; Qin, Yan; Wu, Jianqiang; Sun, Guiling

    2016-01-01

    A growing body of evidence is pointing to an important role of horizontal gene transfer (HGT) in the evolution of higher plants. However, reports of HGTs of transposable elements (TEs) in plants are still scarce, and only one case is known of a class II transposon horizontally transferred between grasses. To investigate possible TE transfers in dicots, we performed transcriptome screening in the obligate root parasite Phelipanche aegyptiaca (Orobanchaceae), data-mining in the draft genome assemblies of four other Orobanchaceae, gene cloning, gene annotation in species with genomic information, and a molecular phylogenetic analysis. We discovered that the broomrape genera Phelipanche and Orobanche acquired two related nuclear genes (christened BO transposase genes), a new group of the hAT superfamily of class II transposons, from Asian Sisymbrieae or a closely related tribe of Brassicaceae, by HGT. The collinearity of the flanking genes, lack of a classic border structure, and low expression levels suggest that BO transposase genes cannot transpose in Brassicaceae, whereas they are highly expressed in P. aegyptiaca. PMID:27452947

  16. Buckling and limit states of composite profiles with top-hat channel section subjected to axial compression

    Science.gov (United States)

    RóŻyło, Patryk; Debski, Hubert; Kral, Jan

    2018-01-01

    The subject of the research was a short thin-walled top-hat cross-section composite profile. The tested structure was subjected to axial compression. As part of the critical state research, critical load and the corresponding buckling mode was determined. Later in the study laminate damage areas were determined throughout numerical analysis. It was assumed that the profile is simply supported on the cross sections ends. Experimental tests were carried out on a universal testing machine Zwick Z100 and the results were compared with the results of numerical calculations. The eigenvalue problem and a non-linear problem of stability of thin-walled structures were carried out by the use of commercial software ABAQUS®. In the presented cases, it was assumed that the material is linear-elastic and non-linearity of the model results from the large displacements. Solution to the geometrically nonlinear problem was conducted by the use of the incremental-iterative Newton-Raphson method.

  17. Peak center and area estimation in gamma-ray energy spectra using a Mexican-hat wavelet

    Energy Technology Data Exchange (ETDEWEB)

    Qin, Zhang-jian; Chen, Chuan; Luo, Jun-song; Xie, Xing-hong; Ge, Liang-quan [School of Information Science & Technology, Chengdu University of Technology, Chengdu (China); Wu, Qi-fan [Department of Engineering Physics, Tsinghua University, Beijing (China)

    2017-06-21

    Wavelet analysis is commonly used to detect and localize peaks within a signal, such as in Gamma-ray energy spectra. This paper presents a peak area estimation method based on a new wavelet analysis. Another Mexican Hat Wavelet Signal (MHWS) named after the new MHWS is obtained with the convolution of a Gaussian signal and a MHWS. During the transform, the overlapping background on the Gaussian signal caused by Compton scattering can be subtracted because the impulse response function MHWS is a second-order smooth function, and the amplitude of the maximum within the new MHWS is the net height corresponding to the Gaussian signal height, which can be used to estimate the Gaussian peak area. Moreover, the zero-crossing points within the new MHWS contain the information of the Gaussian variance whose valve should be obtained when the Gaussian peak area is estimated. Further, the new MHWS center is also the Gaussian peak center. With that distinguishing feature, the channel address of a characteristic peak center can be accurately obtained which is very useful in the stabilization of airborne Gamma energy spectra. In particular, a method for determining the correction coefficient k is given, where the peak area is calculated inaccurately because the value of the scale factor in wavelet transform is too small. The simulation and practical applications show the feasibility of the proposed peak center and area estimation method.

  18. THE HAT-P-13 EXOPLANETARY SYSTEM: EVIDENCE FOR SPIN-ORBIT ALIGNMENT AND A THIRD COMPANION

    International Nuclear Information System (INIS)

    Winn, Joshua N.; Albrecht, Simon; Johnson, John Asher; Howard, Andrew W.; Marcy, Geoffrey W.; Bakos, Gaspar A.; Hartman, Joel; Torres, Guillermo; Narita, Norio

    2010-01-01

    We present new radial velocity (RV) measurements of HAT-P-13, a star with two previously known companions: a transiting giant planet 'b' with an orbital period of 3 days and a more massive object 'c' on a 1.2 yr, highly eccentric orbit. For this system, dynamical considerations would lead to constraints on planet b's interior structure, if it could be shown that the orbits are coplanar and apsidally locked. By modeling the Rossiter-McLaughlin effect, we show that planet b's orbital angular momentum vector and the stellar spin vector are well aligned on the sky (λ = 1.9 ± 8.6 deg). The refined orbital solution favors a slightly eccentric orbit for planet b (e = 0.0133 ± 0.0041), although it is not clear whether it is apsidally locked with c's orbit (Δω = 36 +27 -36 deg). We find a long-term trend in the star's RV and interpret it as evidence for an additional body 'd', which may be another planet or a low-mass star. Predictions are given for the next few inferior conjunctions of c, when transits may happen.

  19. Single step synthesis of gold-amino acid composite, with the evidence of the catalytic hydrogen atom transfer (HAT) reaction, for the electrochemical recognition of Serotonin

    Science.gov (United States)

    Choudhary, Meenakshi; Siwal, Samarjeet; Nandi, Debkumar; Mallick, Kaushik

    2016-03-01

    A composite architecture of amino acid and gold nanoparticles has been synthesized using a generic route of 'in-situ polymerization and composite formation (IPCF)' [1,2]. The formation mechanism of the composite has been supported by a model hydrogen atom (H•≡H++e-) transfer (HAT) type of reaction which belongs to the proton coupled electron transfer (PCET) mechanism. The 'gold-amino acid composite' was used as a catalyst for the electrochemical recognition of Serotonin.

  20. Performance of the SD BIOLINE® HAT rapid test in various diagnostic algorithms for gambiense human African trypanosomiasis in the Democratic Republic of the Congo.

    Directory of Open Access Journals (Sweden)

    Crispin Lumbala

    Full Text Available We carried out a study to compare the performance, in terms of sensitivity and specificity, of the new SD BIOLINE® HAT rapid diagnostic test (RDT with the card agglutination test for trypanosomiasis (CATT for diagnosis of human African trypanosomiasis (HAT in the Democratic Republic of the Congo (DRC. Participants were enrolled actively by four mobile teams, and passively at four health facilities in three provinces. Consenting participants were tested concurrently with the RDT and CATT on whole blood. Those found positive by either test were tested with CATT on serial dilutions of plasma, and with a parasitological composite reference standard (CRS. Cases were only the individuals found positive by the CRS, while controls were negative by both CATT and RDT, as well as those that were positive by CATT or RDT, but were negative by the CRS, and had no history of HAT. Over five months, 131 cases and 13,527 controls were enrolled. The sensitivity of the RDT was 92.0% (95% confidence interval (CI = 86.1-95.5, which was significantly higher than CATT (sensitivity 69.1%; 95% CI = 60.7-76.4. The sensitivity of CATT on plasma at a dilution of 1:8 was 59.0% (95% CI = 50.2-67.2. The specificity of the RDT was 97.1% (95% CIs = 96.8-97.4 while that of CATT was 98.0% (95% CIs = 97.8, 98.2 and specificities of algorithms involving CATT at 1:8 dilution were 99.6% (95% CI = 99.5-99.7. Reproducibility of results was excellent. We concluded that an algorithm in which the SD BIOLINE® HAT RDT is used for screening is optimal for case detection in both passive and active screening settings. However, the lower specificity of the RDT compared to that of CATT would result in a larger number of false positive individuals undergoing confirmatory testing.

  1. Performance of the SD BIOLINE® HAT rapid test in various diagnostic algorithms for gambiense human African trypanosomiasis in the Democratic Republic of the Congo.

    Science.gov (United States)

    Lumbala, Crispin; Bessell, Paul R; Lutumba, Pascal; Baloji, Sylvain; Biéler, Sylvain; Ndung'u, Joseph M

    2017-01-01

    We carried out a study to compare the performance, in terms of sensitivity and specificity, of the new SD BIOLINE® HAT rapid diagnostic test (RDT) with the card agglutination test for trypanosomiasis (CATT) for diagnosis of human African trypanosomiasis (HAT) in the Democratic Republic of the Congo (DRC). Participants were enrolled actively by four mobile teams, and passively at four health facilities in three provinces. Consenting participants were tested concurrently with the RDT and CATT on whole blood. Those found positive by either test were tested with CATT on serial dilutions of plasma, and with a parasitological composite reference standard (CRS). Cases were only the individuals found positive by the CRS, while controls were negative by both CATT and RDT, as well as those that were positive by CATT or RDT, but were negative by the CRS, and had no history of HAT. Over five months, 131 cases and 13,527 controls were enrolled. The sensitivity of the RDT was 92.0% (95% confidence interval (CI) = 86.1-95.5), which was significantly higher than CATT (sensitivity 69.1%; 95% CI = 60.7-76.4). The sensitivity of CATT on plasma at a dilution of 1:8 was 59.0% (95% CI = 50.2-67.2). The specificity of the RDT was 97.1% (95% CIs = 96.8-97.4) while that of CATT was 98.0% (95% CIs = 97.8, 98.2) and specificities of algorithms involving CATT at 1:8 dilution were 99.6% (95% CI = 99.5-99.7). Reproducibility of results was excellent. We concluded that an algorithm in which the SD BIOLINE® HAT RDT is used for screening is optimal for case detection in both passive and active screening settings. However, the lower specificity of the RDT compared to that of CATT would result in a larger number of false positive individuals undergoing confirmatory testing.

  2. THE STELLAR OBLIQUITY AND THE LONG-PERIOD PLANET IN THE HAT-P-17 EXOPLANETARY SYSTEM

    Energy Technology Data Exchange (ETDEWEB)

    Fulton, Benjamin J.; Howard, Andrew W. [Institute for Astronomy, University of Hawaii at Manoa, 2680 Woodlawn Dr, Honolulu, HI 96822 (United States); Winn, Joshua N.; Albrecht, Simon [Department of Physics and Kavli Institute for Astrophysics and Space Research, Massachusetts Institute of Technology, Cambridge, MA 02139 (United States); Marcy, Geoffrey W.; Isaacson, Howard [University of California, Berkeley, Berkeley, CA (United States); Crepp, Justin R. [University of Notre Dame, Department of Physics, Notre Dame, IN (United States); Bakos, Gaspar A.; Hartman, Joel D. [Princeton University, Department of Astrophysical Sciences, Princeton, NJ (United States); Johnson, John Asher; Knutson, Heather A. [California Institute of Technology, Pasadena, CA (United States); Zhao Ming [Department of Astronomy and Astrophysics, 525 Davey Laboratory, Pennsylvania State University, University Park, PA 16802 (United States)

    2013-08-01

    We present the measured projected obliquity-the sky-projected angle between the stellar spin axis and orbital angular momentum-of the inner planet of the HAT-P-17 multi-planet system. We measure the sky-projected obliquity of the star to be {lambda}=19{sup +14}{sub -16} deg by modeling the Rossiter-McLaughlin effect in Keck/HIRES radial velocities (RVs). The anomalous RV time series shows an asymmetry relative to the midtransit time, ordinarily suggesting a nonzero obliquity-but in this case at least part of the asymmetry may be due to the convective blueshift, increasing the uncertainty in the determination of {lambda}. We employ the semi-analytical approach of Hirano et al. that includes the effects of macroturbulence, instrumental broadening, and convective blueshift to accurately model the anomaly in the net RV caused by the planet eclipsing part of the rotating star. Obliquity measurements are an important tool for testing theories of planet formation and migration. To date, the measured obliquities of {approx}50 Jovian planets span the full range, from prograde to retrograde, with planets orbiting cool stars preferentially showing alignment of stellar spins and planetary orbits. Our results are consistent with this pattern emerging from tidal interactions in the convective envelopes of cool stars and close-in planets. In addition, our 1.8 yr of new RVs for this system show that the orbit of the outer planet is more poorly constrained than previously thought, with an orbital period now in the range of 10-36 yr.

  3. Quality of life effects of automatic external defibrillators in the home: results from the Home Automatic External Defibrillator Trial (HAT).

    Science.gov (United States)

    Mark, Daniel B; Anstrom, Kevin J; McNulty, Steven E; Flaker, Greg C; Tonkin, Andrew M; Smith, Warren M; Toff, William D; Dorian, Paul; Clapp-Channing, Nancy E; Anderson, Jill; Johnson, George; Schron, Eleanor B; Poole, Jeanne E; Lee, Kerry L; Bardy, Gust H

    2010-04-01

    Public access automatic external defibrillators (AEDs) can save lives, but most deaths from out-of-hospital sudden cardiac arrest occur at home. The Home Automatic External Defibrillator Trial (HAT) found no survival advantage for adding a home AED to cardiopulmonary resuscitation (CPR) training for 7,001 patients with a prior anterior wall myocardial infarction. Quality of life (QOL) outcomes for both the patient and spouse/companion were secondary end points. A subset of 1,007 study patients and their spouse/companions was randomly selected for ascertainment of QOL by structured interview at baseline and 12 and 24 months after enrollment. The primary QOL measures were the Medical Outcomes Study 36-Item Short-Form psychological well-being (reflecting anxiety and depression) and vitality (reflecting energy and fatigue) subscales. For patients and spouse/companions, the psychological well-being and vitality scales did not differ significantly between those randomly assigned an AED plus CPR training and controls who received CPR training only. None of the other QOL measures collected showed a clinically and statistically significant difference between treatment groups. Patients in the AED group were more likely to report being extremely or quite a bit reassured by their treatment assignment. Spouse/companions in the AED group reported being less often nervous about the possibility of using AED/CPR treatment than those in the CPR group. Adding access to a home AED to CPR training did not affect QOL either for patients with a prior anterior myocardial infarction or their spouse/companion but did provide more reassurance to the patients without increasing anxiety for spouse/companions. Copyright 2010 Mosby, Inc. All rights reserved.

  4. Characterization and biological treatment of colored textile wastewaters from the typical Tunisian hat Chechia dyeing using newly isolated Aspergillus niger

    Directory of Open Access Journals (Sweden)

    Hajer Barouni

    2016-09-01

    Full Text Available This study aimed to characterize and investigate, for the first time, the treatment of real colored wastewaters from the artisanal dyeing of the typical Tunisian hat Chechia, using a newly isolated fungal strain. This textile effluent was a mixture called Mix of colored wastewaters from the three main types of Chechia. The major pollutant of the Mix was the toxic Azo dye Amaranth Acid or Acid Red 27. The fungal strain that made the cleanup was discovered in a Chechia dyeing wastewater’s container and identified by ITS rDNA gene sequencing. This isolated Aspergillus niger showed interesting performances on the demonstration of Chechia wastewater’s biodegradation in batch cultures. In order to understand the effect of agitation, Mix dilution and inoculum size on decolourisation and pollution removal, a full factorial experimental design 23 was set up. At the optimal conditions which were 20% inoculum size, 25% Chechia Mix dilution and an agitation of 100 rpm, Aspergillus niger was able to remove color as high as 70.18±2.84% at an initial dye concentration of 1346.6±0.01 mg/L, and to reduce COD to 74.17±14.52% at an initial COD of 4157±422 mg/L. FT-IR spectra analysis confirmed the decolourisation by biodegradation and transformation of the dyes. The treatment by the isolated Aspergillus niger could be successfully applied as a sustainable method to solve one of handicraft dyeing plants environmental management issues.

  5. Classification of Ultra-High Resolution Orthophotos Combined with DSM Using a Dual Morphological Top Hat Profile

    Directory of Open Access Journals (Sweden)

    Qian Zhang

    2015-12-01

    Full Text Available New aerial sensors and platforms (e.g., unmanned aerial vehicles (UAVs are capable of providing ultra-high resolution remote sensing data (less than a 30-cm ground sampling distance (GSD. This type of data is an important source for interpreting sub-building level objects; however, it has not yet been explored. The large-scale differences of urban objects, the high spectral variability and the large perspective effect bring difficulties to the design of descriptive features. Therefore, features representing the spatial information of the objects are essential for dealing with the spectral ambiguity. In this paper, we proposed a dual morphology top-hat profile (DMTHP using both morphology reconstruction and erosion with different granularities. Due to the high dimensional feature space, we have proposed an adaptive scale selection procedure to reduce the feature dimension according to the training samples. The DMTHP is extracted from both images and Digital Surface Models (DSM to obtain complimentary information. The random forest classifier is used to classify the features hierarchically. Quantitative experimental results on aerial images with 9-cm and UAV images with 5-cm GSD are performed. Under our experiments, improvements of 10% and 2% in overall accuracy are obtained in comparison with the well-known differential morphological profile (DMP feature, and superior performance is observed over other tested features. Large format data with 20,000 × 20,000 pixels are used to perform a qualitative experiment using the proposed method, which shows its promising potential. The experiments also demonstrate that the DSM information has greatly enhanced the classification accuracy. In the best case in our experiment, it gives rise to a classification accuracy from 63.93% (spectral information only to 94.48% (the proposed method.

  6. RIP1-HAT1-SirT complex identification and targeting in treatment and prevention of cancer.

    Science.gov (United States)

    Carafa, Vincenzo; Nebbioso, Angela; Cuomo, Francesca; Rotili, Dante; Cobellis, Gilda; Bontempo, Paola; Baldi, Alfonso; Spugnini, Enrico P; Citro, Gennaro; Chambery, Angela; Russo, Rosita; Ruvo, Menotti; Ciana, Paolo; Maravigna, Luca; Shaik, Jani; Radaelli, Enrico; De Antonellis, Pasqualino; Tarantino, Domenico; Pirolli, Adele; Ragno, Rino; Zollo, Massimo; Stunnenberg, Hendrik G; Mai, Antonello; Altucci, Lucia

    2018-03-13

    Alteration in cell death is a hallmark of cancer. A functional role regulating survival, apoptosis and necroptosis has been attributed to RIP1/3 complexes. We have investigated the role of RIP1 and the effects of MC2494 in cell death induction, using different methods as flow cytometry, transcriptome analysis, immunoprecipitation, enzymatic assays, transfections, mutagenesis and in vivo studies with different mice models. Here, we show that RIP1 is highly expressed in cancer and we define a novel RIP1/3-SIRT1/2-HAT1/4 complex. Mass Spectrometry identified 5 acetylations in the kinase and death domain of RIP1. The novel characterised pan-SirT inhibitor, MC2494, increases RIP1 acetylation at 2 additional sites in the death domain. Mutagenesis of the acetylated lysine decreases RIP1-dependent cell death suggesting a role for acetylation of the RIP1 complex in cell death modulation. Accordingly, MC2494 displays tumour-selective potential in vitro, in leukemic blasts ex vivo, and in vivo in both xenograft and allograft cancer models. Mechanistically, MC2494 induces bona fide tumour-restricted acetylated RIP1/caspase-8-mediated apoptosis. Excitingly, MC2494 displays tumour-preventive activity by blocking DMBA-induced mammary gland hyper-proliferation in vivo. These preventive features might prove useful in patients who may benefit from a recurrence-preventive approach with low toxicity during follow-up phases and in cases of established cancer predisposition. Thus, targeting the newly identified RIP1 complex may represent an attractive novel paradigm in cancer treatment and prevention. Copyright ©2018, American Association for Cancer Research.

  7. Household wireless electroencephalogram hat

    Science.gov (United States)

    Szu, Harold; Hsu, Charles; Moon, Gyu; Yamakawa, Takeshi; Tran, Binh

    2012-06-01

    We applied Compressive Sensing to design an affordable, convenient Brain Machine Interface (BMI) measuring the high spatial density, and real-time process of Electroencephalogram (EEG) brainwaves by a Smartphone. It is useful for therapeutic and mental health monitoring, learning disability biofeedback, handicap interfaces, and war gaming. Its spec is adequate for a biomedical laboratory, without the cables hanging over the head and tethered to a fixed computer terminal. Our improved the intrinsic signal to noise ratio (SNR) by using the non-uniform placement of the measuring electrodes to create the proximity of measurement to the source effect. We computing a spatiotemporal average the larger magnitude of EEG data centers in 0.3 second taking on tethered laboratory data, using fuzzy logic, and computing the inside brainwave sources, by Independent Component Analysis (ICA). Consequently, we can overlay them together by non-uniform electrode distribution enhancing the signal noise ratio and therefore the degree of sparseness by threshold. We overcame the conflicting requirements between a high spatial electrode density and precise temporal resolution (beyond Event Related Potential (ERP) P300 brainwave at 0.3 sec), and Smartphone wireless bottleneck of spatiotemporal throughput rate. Our main contribution in this paper is the quality and the speed of iterative compressed image recovery algorithm based on a Block Sparse Code (Baranuick et al, IEEE/IT 2008). As a result, we achieved real-time wireless dynamic measurement of EEG brainwaves, matching well with traditionally tethered high density EEG.

  8. The N-kink, bell-shape and hat-shape solitary solutions of b-family equation in the case of b=0

    Energy Technology Data Exchange (ETDEWEB)

    Xia, Baoqiang, E-mail: xiabaoqiang@126.com [School of Mathematics and Statistics, Jiangsu Normal University, Xuzhou, Jiangsu 221116 (China); Qiao, Zhijun, E-mail: qiao@utpa.edu [Department of Mathematics, University of Texas-Pan American, Edinburg, TX 78541 (United States)

    2013-11-08

    In this Letter, we study the solutions of equation m{sub t}=m{sub x}u, m=u−u{sub xx}, which actually comes from the so-called b-family equation m{sub t}=m{sub x}u+bmu{sub x}, m=u−u{sub xx} in the case of b=0. We show that this equation admits both N-peakon and N-kink solutions. In particular, the bell-shape soliton, hat-shape soliton, single-kink, and two-kink solutions are presented in an explicit formula.

  9. Az egykulcsos személyi jövedelemadó várható hatásai az agrárfoglalkoztatásra

    OpenAIRE

    Horvath, Gabor; Paragi, Marton

    2011-01-01

    A személyi jövedelemadó rendszert érintő 2011. évi változásokkal kapcsolatban elhangzott vélemények és értékelések rendkívül egysíkúak. A változások és az eredmények bemutatásakor az adózó magánszemélyt állították a középpontba, a magánszemélyeket érő pozitív és negatív hatásokat összevetve, s így mérleget vonva. Az intézkedések gazdaságpolitikai dimenzióit ugyanakkor figyelmen kívül hagyták: az ágazati szinten megnyilvánuló hatások számszerűsítése, illetve a makrogazdasági következmények öss...

  10. The HAT TRICK programme for improving physical activity, healthy eating and connectedness among overweight, inactive men: study protocol of a pragmatic feasibility trial.

    Science.gov (United States)

    Caperchione, Cristina M; Bottorff, Joan L; Oliffe, John L; Johnson, Steven T; Hunt, Kate; Sharp, Paul; Fitzpatrick, Kayla M; Price, Ryley; Goldenberg, S Larry

    2017-09-06

    Physical activity, healthy eating and maintaining a healthy weight are associated with reduced risk of cardiovascular disease, type 2 diabetes and cancer and with improved mental health. Despite these benefits, many men do not meet recommended physical activity guidelines and have poor eating behaviours. Many health promotion programmes hold little appeal to men and consequently fail to influence men's health practices. HAT TRICK was designed as a 12-week face-to-face, gender-sensitised intervention for overweight and inactive men focusing on physical activity, healthy eating and social connectedness and was delivered in collaboration with a major junior Canadian ice hockey team (age range 16-20 years). The programme was implemented and evaluated to assess its feasibility. This article describes the intervention design and study protocol of HAT TRICK. HAT TRICK participants (n=60) were men age 35 years, residing in the Okanagan Region of British Columbia, who accumulate 150 min of moderate to vigorous physical activity a week, with a body mass index of >25 kg/m 2 and a pant waist size of >38'. Each 90 min weekly session included targeted health education and theory-guided behavioural change techniques, as well as a progressive (ie, an increase in duration and intensity) group physical activity component. Outcome measures were collected at baseline, 12 weeks and 9 months and included the following: objectively measured anthropometrics, blood pressure, heart rate, physical activity and sedentary behaviour, as well as self-reported physical activity, sedentary behaviour, diet, smoking, alcohol consumption, sleep habits, risk of depression, health-related quality of life and social connectedness. Programme feasibility data (eg, recruitment, satisfaction, adherence, content delivery) were assessed at 12 weeks via interviews and self-report. Ethical approval was obtained from the University of British Columbia Okanagan Behavioural Research Ethics Board (reference no H

  11. Modification to the Remedial Action Plan and site design for stabilization of the inactive uranium mill tailings site at Mexican Hat, Utah: Volume 1, Text, Attachments 1--6. Final report

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1989-01-01

    This document provides the modifications to the 1988 Remedial Action Plan (RAP) of the contaminated materials at the Monument Valley, Arizona, and Mexican Hat, Utah. The text detailing the modifications and attachments 1 through 6 are provided with this document. The RAP was developed to serve a two-fold purpose. It presents the activities proposed by the Department of Energy (DOE) to accomplish long-term stabilization and control of the residual radioactive materials (RRM) from Monument Valley, Arizona, and Mexican Hat, Utah, at the Mexican Hat disposal site. It also serves to document the concurrence of both the Navajo Nation and the Nuclear Regulatory Commission (NRC) in the remedial action. This agreement, upon execution by DOE and the Navajo Nation and concurrence by the NRC, becomes Appendix B of the Cooperative Agreement. This document has been structured to provide a comprehensive understanding of the remedial action proposed for the Monument Valley and Mexican Hat sites. It includes specific design and construction requirements for the remedial action. Pertinent information and data are included with reference given to the supporting documents.

  12. Hubble PanCET: an isothermal day-side atmosphere for the bloated gas-giant HAT-P-32Ab

    Science.gov (United States)

    Nikolov, N.; Sing, D. K.; Goyal, J.; Henry, G. W.; Wakeford, H. R.; Evans, T. M.; López-Morales, M.; García Muñoz, A.; Ben-Jaffel, L.; Sanz-Forcada, J.; Ballester, G. E.; Kataria, T.; Barstow, J. K.; Bourrier, V.; Buchhave, L. A.; Cohen, O.; Deming, D.; Ehrenreich, D.; Knutson, H.; Lavvas, P.; Lecavelier des Etangs, A.; Lewis, N. K.; Mandell, A. M.; Williamson, M. H.

    2018-02-01

    We present a thermal emission spectrum of the bloated hot Jupiter HAT-P-32Ab from a single eclipse observation made in spatial scan mode with the Wide Field Camera 3 (WFC3) aboard the Hubble Space Telescope (HST). The spectrum covers the wavelength regime from 1.123 to 1.644 μm which is binned into 14 eclipse depths measured to an averaged precision of 104 parts-per million. The spectrum is unaffected by a dilution from the close M-dwarf companion HAT-P-32B, which was fully resolved. We complemented our spectrum with literature results and performed a comparative forward and retrieval analysis with the 1D radiative-convective ATMO model. Assuming solar abundance of the planet atmosphere, we find that the measured spectrum can best be explained by the spectrum of a blackbody isothermal atmosphere with Tp = 1995 ± 17 K, but can equally well be described by a spectrum with modest thermal inversion. The retrieved spectrum suggests emission from VO at the WFC3 wavelengths and no evidence of the 1.4 μm water feature. The emission models with temperature profiles decreasing with height are rejected at a high confidence. An isothermal or inverted spectrum can imply a clear atmosphere with an absorber, a dusty cloud deck or a combination of both. We find that the planet can have continuum of values for the albedo and recirculation, ranging from high albedo and poor recirculation to low albedo and efficient recirculation. Optical spectroscopy of the planet's day-side or thermal emission phase curves can potentially resolve the current albedo with recirculation degeneracy.

  13. Identification of a high frequency transposon induced by tissue culture, nDaiZ, a member of the hAT family in rice.

    Science.gov (United States)

    Huang, Jian; Zhang, Kewei; Shen, Yi; Huang, Zejun; Li, Ming; Tang, Ding; Gu, Minghong; Cheng, Zhukuan

    2009-03-01

    Recent completion of rice genome sequencing has revealed that more than 40% of its genome consists of repetitive sequences, and most of them are related to inactive transposable elements. In the present study, a transposable element, nDaiZ0, which is induced by tissue culture with high frequency, was identified by sequence analysis of an allelic line of the golden hull and internode 2 (gh2) mutant, which was integrated into the forth exon of GH2. The 528-bp nDaiZ0 has 14-bp terminal inverted repeats (TIRs), and generates an 8-bp duplication of its target sites (TSD) during its mobilization. nDaiZs are non-autonomous transposons and have no coding capacity. Bioinformatics analysis and southern blot hybridization showed that at least 16 copies of nDaiZ elements exist in the japonica cultivar Nipponbare genome and 11 copies in the indica cultivar 93-11 genome. During tissue culture, only one copy, nDaiZ9, located on chromosome 5 in the genome of Nipponbare can be activated with its transposable frequency reaching 30%. However, nDaiZ9 was not present in the 93-11 genome. The larger elements, DaiZs, were further identified by database searching using nDaiZ0 as a query because they share similar TIRs and subterminal sequences. DaiZ can also generate an 8-bp TSD. DaiZ elements contain a conserved region with a high similarity to the hAT dimerization motif, suggesting that the nDaiZ-DaiZ transposon system probably belongs to the hAT superfamily of class II transposons. Phylogenetic analysis indicated that it is a new type of plant hAT-like transposon. Although nDaiZ is activated by tissue culture, the high transposable frequency indicates that it could become a useful gene tagging system for rice functional genomic studies. In addition, the mechanism of the high transposable ability of nDaiZ9 is discussed.

  14. The significance of the Medicine Hat Block (southern Alberta, northern Montana) in the assembly of Laurentia: New interpretations from recent single grain zircon geochronological and geochemical data

    Science.gov (United States)

    LaDouceur, B. O.; Gifford, J.; Malone, S.; Davis, B.

    2017-12-01

    Keywords: Medicine Hat Block, Zircon, U/Pb ages, Hf isotopes, Laurentia The Medicine Hat Block (MHB) is one of the core cratonic elements that amalgamated in the Paleoproterozoic to form Laurentia. However, unlike many of the other cratons, the role of the MHB in the formation of Laurentia is poorly constrained. Virtually all of the MHB is concealed by Proterozoic and younger supracrustal sequences, limiting the data collected from this craton. The primary source of samples from the MHB comes from two sources: 1) xenoliths of variably metamorphoses gneisses, amphibolites, and meta-plutonic rocks collected from Eocene volcanic rock, and 2) similar lithologies recovered from boreholes that penetrate to the MHB basement. Multigrain zircon TIMS analyses yielded U/Pb ages ranging from 1.70 Ga to 3.26 Ga. Recent zircon single-grain LA-ICPMS U-Pb ages revealed a slightly older range of Archean ages, 2.63 Ga to 3.27 Ga, and two samples yielding Paleoproterozoic ages at 1.78 and 1.82 Ga. Whole-rock Sm/Nd data indicated that the samples formed from crustal sources, with model ages ranging between 1.80 Ga to 3.48 Ga. In-situ zircon Hf isotopic results revealed that Archean-aged zircon are generally suprachondritic, with eHf(t) values between 8.3 and -8.7. In contrast, the Paleoproterozoic grains yielded negative eHf(t) values ranging from -6.8 to -21.2, suggestive of a reworked Archean crustal component in their genesis. In particular, the Sweetgrass Hill xenolith suite is characterized solely by Paleoproterozoic ages, with evolved eHf(t) suggesting that any older U-Pb ages were reset by granulite facies metamorphism and zircon recrystallization. The combined U-Pb and Hf isotopic data from these samples helps illuminate the character of the MHB and its relationships to the Wyoming and Hearne cratons, as well as the Great Falls Tectonic Zone (GFTZ). The ages overlap between cratonic elements; however, the abundance of positive eHf(t) values of the 2.8 Ga ages suggests that the

  15. Tectonic geomorphology and volcano-tectonic interaction in the eastern boundary of the Southern Cascades (Hat Creek Graben region, California, USA

    Directory of Open Access Journals (Sweden)

    Engielle Mae Raot-raot Paguican

    2016-07-01

    Full Text Available The eastern boundary of the Southern Cascades (Hat Creek Graben region, California, USA, is an extensively faulted volcanic corridor between the Cascade Range and Modoc Plateau. The east-west extending region is in the transition zone between the convergence and subduction of the Gorda Plate underneath the North American Plate; north-south shortening within the Klamath Mountain region; and transcurrent movement in the Walker Lane. We describe the geomorphological and tectonic features, their alignment and distribution, in order to understand the tectonic geomorphology and volcano-tectonic relationships. One outcome of the work is a more refined morpho-structural description that will affect future hazard assessment in the area.A database of volcanic centers and structures was created from interpretations of topographic models generated from satellite images. Volcanic centers in the region were classified by morphological type into cones, sub-cones, shields and massifs. A second classification by height separated the bigger and smaller edifices and revealed an evolutionary trend. Poisson Nearest Neighbor analysis shows that bigger volcanoes are spatially dispersed while smaller ones are clustered. Using volcano centroid locations, about 90 lineaments consisting of at least three centers within 6km of one another were found, revealing that preferential north-northwest directed pathways control the transport of magma from the source to the surface, consistent with the strikes of the major fault systems. Most of the volcano crater openings are perpendicular to the maximum horizontal stress, expected for extensional environments with dominant normal regional faults. These results imply that the extension of the Hat Creek Graben region and impingement of the Walker Lane is accommodated mostly by extensional faults and partly by the intrusions that formed the volcanoes. Early in the history of a volcano or volcano cluster, melt produced at depth in the

  16. Investigations of solution-processed charge generation unit with low concentration of small molecule doped in p-type/HAT-CN{sub 6} for tandem OLED

    Energy Technology Data Exchange (ETDEWEB)

    Talik, N.A., E-mail: azrina_talik@hotmail.com [Low Dimensional Material Research Centre (LDMRC), Physics Dept., Faculty of Science, University of Malaya, 50603 Kuala Lumpur (Malaysia); Yeoh, K.H. [Low Dimensional Material Research Centre (LDMRC), Physics Dept., Faculty of Science, University of Malaya, 50603 Kuala Lumpur (Malaysia); Centre for Photonics and Advanced Materials Research (CPR), Lee Kong Chian Faculty of Engineering and Science, University Tunku Abdul Rahman, 43000 Kajang, Selangor (Malaysia); Ng, C.Y.B. [Low Dimensional Material Research Centre (LDMRC), Physics Dept., Faculty of Science, University of Malaya, 50603 Kuala Lumpur (Malaysia); Tan, C.Y. [Centre of Advanced Manufacturing & Material Processing (AMMP), Department of Mechanical Engineering, Faculty of Engineering, University of Malaya, 50603 Kuala Lumpur (Malaysia); Yap, B.K., E-mail: kbyap@uniten.edu.my [Centre of Microelectronic and Nano Engineering (CeMNE), College of Engineering, Universiti Tenaga Nasional, 43000 Kajang, Selangor (Malaysia)

    2016-01-15

    We investigated the charge generation and injection mechanism in solution processed charge generation unit (CGU) used in our high performance tandem organic light emitting diode (OLED) via capacitance–voltage (C–V) and current density–voltage (J–V) measurements. By doping 2 wt% of small molecule 1,1-bis-(4-bis(4-tolyl)-aminophenyl) cyclohexene (TAPC) into Poly (N-vinylcarbazole) (PVK) as p-type layer of the CGU, we obtained more than two folds improvement in the tandem device efficiency compared to single device. The performance improvement of the TAPC doped CGU could be attributed to low built-in potential, large vacuum level shift as well as high charge density for efficient charge generation. - Highlights: • Charge-generation and injection mechanism in CGU for tandem OLED is investigated. • Small molecule, TAPC doped in p-type/HAT-CN{sub 6} has been used for tandem OLED. • The improvement attributes to the lower V{sub bi} and larger ΔV{sub L} in doped layer. • Narrower W and high carrier density also contribute to efficiency improvement.

  17. High-resolution, Two-Dimensional Geophysical Investigation of several small faults at the northern end of the Hat Creek graben, Shasta, Californi

    Science.gov (United States)

    Kozaci, O.; O'Connell, D. R. H.; Page, W. D.

    2014-12-01

    Several faults were identified as Quaternary in age near the Pit River at the northern end of the Hat Creek graben based on their geomorphic expression. Preliminary paleoseismic trenching confirmed that Fault 3432 had displacements in the late Quaternary indicating that it is with long recurrence, but the style of faulting and its role within the greater geologic context remains unresolved. Detailed site-specific geophysical investigations were performed in order to help characterize the Fault 3432 and plan future paleoseismic investigations. Seven two-dimensional seismic reflection lines were acquired using a distributed networked recording configuration. Standard seismic reflection processing and surface wave processing using IMASW were performed to resolve shallow stratigraphy within Camp Shasta Basin and Burney Mountain Hillside Basin locations. Using this data combined with geomorphology facilitated our mapping and interpretation of fault zone architecture within the study area. In both Camp Shasta and Burney Mountain locations, seismic reflection data helped locate discrete fault strands extending near surface. In addition, our interpretation of seismic profiles show that near-vertical steep faults merge at depth indicating negative flower structure. This fault structure suggests that the dominant style of faulting in the study area is strike slip with a normal component.

  18. Peptide Inhibitor of Complement C1 (PIC1) demonstrates antioxidant activity via single electron transport (SET) and hydrogen atom transfer (HAT).

    Science.gov (United States)

    Gregory Rivera, Magdielis; Hair, Pamela S; Cunnion, Kenji M; Krishna, Neel K

    2018-01-01

    Reactive oxygen species (ROS) are natural byproducts of oxidative respiration that are toxic to organs and tissues. To mitigate ROS damage, organisms have evolved a variety of antioxidant systems to counteract these harmful molecules, however in certain pathological conditions these protective mechanisms can be overwhelmed. We have recently demonstrated that Peptide Inhibitor of Complement C1 (PIC1) mitigates peroxidase activity of the heme bearing proteins myeloperoxidase, hemoglobin, and myoglobin through a reversible process. To determine if this property of PIC1 was antioxidant in nature, we tested PIC1 in a number of well-established antioxidant assays. PIC1 showed dose-dependent antioxidant activity in a total antioxidant (TAC) assay, hydroxyl radical antioxidant capacity (HORAC) assay, oxygen radical antioxidant capacity (ORAC) assay as well as the thiobarbituric acid reactive substances (TBARS) assay to screen for PIC1 antioxidant activity in human plasma. The antioxidant activity of PIC1 in the TAC assay, as well as the HORAC/ORAC assay demonstrated that this peptide acts via the single electron transport (SET) and hydrogen atom transfer (HAT) mechanisms, respectively. Consistent with this mechanism of action, PIC1 did not show activity in a metal chelating activity (MCA) assay. PIC1 contains two vicinal cysteine residues and displayed similar antioxidant activity to the well characterized cysteine-containing tripeptide antioxidant molecule glutathione (GSH). Consistent with the role of the cysteine residues in the antioxidant activity of PIC1, oxidation of these residues significantly abrogated antioxidant activity. These results demonstrate that in addition to its described complement inhibiting activity, PIC1 displays in vitro antioxidant activity.

  19. Design of a Family of Ln3 Triangles with the HAT Ligand (1,4,5,8,9,12-Hexaazatriphenylene): Single-Molecule Magnetism.

    Science.gov (United States)

    Díaz-Ortega, Ismael F; Herrera, Juan Manuel; Gupta, Tulika; Rajaraman, Gopalan; Nojiri, Hiroyuki; Colacio, Enrique

    2017-05-15

    A series of trinuclear Ln 3 complexes (Ln III = Yb (1), Er (2), Dy (3) and Gd (4)) were prepared from the tris-chelate bidentate ligand 1,4,5,8,9,12-hexaazatriphenylene (HAT). 1 and 2 exhibited field-induced single-molecule-magnet (SMM) behavior with estimated U eff values of 21.30 and 13.86 K, respectively. Complex 3 behaved as a SMM even at zero field, and two different thermally assisted relaxation processes were detected with U eff values of 29.6 K (fast relaxation process, FR) and 69 K (slow relaxation process, SR) due to the existence of two magnetically different Dy III centers in the molecule. Ab initio studies reveal that all the Dy 3+ centers have almost an Ising ground state. The local anisotropy axes are not coplanar but form angles with the Dy3 plane in the range 58-78°. The magnetic interaction between the anisotropic Dy 3+ ions is antiferromagnetic in nature and very weak in magnitude. However, due to the extreme feebleness of the magnetic interaction with regard to the local excitation energies, the magnetization blockade is most probably of single-ion origin. Calculations support the existence of two relaxation processes, which take place through the first excited state following an Orbach/Raman mechanism. Finally, for complex 4, the magnetocaloric effect was simulated using the magnetic parameters extracted from the fit of the magnetization and susceptibility data and demonstrated that the simulated -ΔS m values were almost coincident with those extracted from the integration of the field dependence of the magnetization. The simulated MCE value at 2 K and 5 T (20.46 J kg -1 K -1 ) makes complex 4 an attractive candidate for cryogenic magnetization.

  20. Histone acetyltransferase (HAT) activity of p300 modulates human T lymphotropic virus type 1 p30II-mediated repression of LTR transcriptional activity

    International Nuclear Information System (INIS)

    Michael, Bindhu; Nair, Amrithraj M.; Datta, Antara; Hiraragi, Hajime; Ratner, Lee; Lairmore, Michael D.

    2006-01-01

    Human T-lymphotropic virus type-1 (HTLV-1) is a deltaretrovirus that causes adult T cell leukemia/lymphoma, and is implicated in a variety of lymphocyte-mediated inflammatory disorders. HTLV-1 provirus has regulatory and accessory genes in four pX open reading frames. HTLV-1 pX ORF-II encodes two proteins, p13 II and p30 II , which are incompletely defined in virus replication or pathogenesis. We have demonstrated that pX ORF-II mutations block virus replication in vivo and that ORF-II encoded p30 II , a nuclear-localizing protein that binds with CREB-binding protein (CBP)/p300, represses CREB and Tax responsive element (TRE)-mediated transcription. Herein, we have identified p30 II motifs important for p300 binding and in regulating TRE-mediated transcription in the absence and presence of HTLV-1 provirus. Within amino acids 100-179 of p30 II , a region important for repression of LTR-mediated transcription, we identified a single lysine residue at amino acid 106 (K3) that significantly modulates the ability of p30 II to repress TRE-mediated transcription. Exogenous p300, in a dose-responsive manner, reverses p30 II -dependent repression of TRE-mediated transcription, in the absence or presence of the provirus, In contrast to wild type p300, p300 HAT mutants (defective in histone acetyltransferase activity) only partially rescued p30 II -mediated LTR repression. Deacetylation by histone deacetylase-1 (HDAC-1) enhanced p30 II -mediated LTR repression, while inhibition of deacetylation by trichostatin A decreases p30 II -mediated LTR repression. Collectively, our data indicate that HTLV-1 p30 II modulates viral gene expression in a cooperative manner with p300-mediated acetylation

  1. An international survey on hypoglycemia among insulin-treated type I and type II diabetes patients: Turkey cohort of the non-interventional IO HAT study.

    Science.gov (United States)

    Emral, Rıfat; Tetiker, Tamer; Sahin, Ibrahim; Sari, Ramazan; Kaya, Ahmet; Yetkin, İlhan; Cil, Sefika Uslu; Tütüncü, Neslihan Başcıl

    2018-02-13

    Limited real-world data are currently available on hypoglycemia in diabetes patients. The International Operations Hypoglycemia Assessment Tool (IO HAT) study was designed to estimate hypoglycemia in insulin-treated type I (T1DM) and type II (T2DM) diabetes mellitus patients from 9 countries. The data from Turkey cohort are presented here. A non-interventional study to determine the hypoglycemia incidence, retrospectively and prospectively, in Turkish T1DM and T2DM patients using a 2-part self-assessment questionnaire. Overall, 2348 patients were enrolled in the Turkey cohort (T1DM = 306 patients, T2DM = 2042 patients). In T1DM patients, 96.8% patients reported hypoglycemic events (Incidence rate [IR]: 68.6 events per patient-year [ppy]), prospectively, while 74.0% patients reported hypoglycemic events (IR: 51.7 events ppy), retrospectively. In T2DM patients, 95.9% patients (IR: 28.3 events ppy) reported hypoglycemic events, prospectively, while 53.6% patients (IR: 23.0 events ppy) reported hypoglycemic events, retrospectively. Nearly all patients reported hypoglycemia during the prospective period. This is a first patient-reported dataset on hypoglycemia in Turkish, insulin-treated diabetes patients. A high incidence of patient-reported hypoglycemia confirms that hypoglycemia remains under-estimated. Hypoglycemia increased healthcare utilization impacting patients' quality of life. Hypoglycemia remains a common side effect with insulin-treatment and strategies to optimize therapy and reduce hypoglycemia occurrence in diabetes patients are required. Clinicaltrials.gov, NCT02306681 (Date of registration: 12 Nov 2014; retrospectively registered).

  2. Smartphone Household Wireless Electroencephalogram Hat

    Directory of Open Access Journals (Sweden)

    Harold Szu

    2013-01-01

    Full Text Available Rudimentary brain machine interface has existed for the gaming industry. Here, we propose a wireless, real-time, and smartphone-based electroencephalogram (EEG system for homecare applications. The system uses high-density dry electrodes and compressive sensing strategies to overcome conflicting requirements between spatial electrode density, temporal resolution, and spatiotemporal throughput rate. Spatial sparseness is addressed by close proximity between active electrodes and desired source locations and using an adaptive selection of N active among 10N passive electrodes to form m-organized random linear combinations of readouts, m≪N≪10N. Temporal sparseness is addressed via parallel frame differences in hardware. During the design phase, we took tethered laboratory EEG dataset and applied fuzzy logic to compute (a spatiotemporal average of larger magnitude EEG data centers in 0.3 second intervals and (b inside brainwave sources by Independent Component Analysis blind deconvolution without knowing the impulse response function. Our main contributions are the fidelity of quality wireless EEG data compared to original tethered data and the speed of compressive image recovery. We have compared our recovery of ill-posed inverse data against results using Block Sparse Code. Future work includes development of strategies to filter unwanted artifact from high-density EEGs (i.e., facial muscle-related events and wireless environmental electromagnetic interferences.

  3. Habitat Testbed (HaT)

    Data.gov (United States)

    National Aeronautics and Space Administration — A key capability of the Deep Space Habitat project is the Deep Space Habitat Testbed. The DSH Testbed serves as the proof of concept and early integration platform...

  4. Welches Geschlecht hat die Avantgarde?

    Directory of Open Access Journals (Sweden)

    Gertrud Lehnert

    2000-07-01

    Full Text Available Das Buch betrachtet das Theater der französischen und amerikanischen ‚Avantgarde‘ der Moderne und Postmoderne unter dem Aspekt des Geschlechts: Welcher Verfahren bedient sich avantgardistische Kunst, ist avantgardistische Kunst in geschlechtlicher Hinsicht restriktiv, oder ermöglicht sie die subversive feministische oder auch lesbisch-schwule Ausformung spezifischer Formen?

  5. Wearing more than one hat?

    DEFF Research Database (Denmark)

    Høgedahl, Laust Kristian; Ibsen, Flemming

    and working conditions in accordance with a private model. This also applies to the use of the so-called weapons of conflict – strikes/blockades and lockouts/boycotts – in connection with labour disputes if the involved parties are unable to reach agreement through negotiations or mediation...

  6. hatü’l-İnsân (Pend-Nâme-i Enûşîrvân’ın Türkçe Bir Tercümesi A Turkish Translation of Râhatü’l-İnsân (Pend-Nâme-i Enûşîrvân

    Directory of Open Access Journals (Sweden)

    Müjgân ÇAKIR

    2012-09-01

    Full Text Available Islamic literatures include many texts on the justice and counsels of Sassanian ruler Nûşîrevân. One of these is a work of Persian Literature which recounts the counsels written on his crown and figures with the titles of “Râhatü’l-insân” or “Pend-nâme-i Enûşîrvân” in some sources. Rıza Kulı Han Hidayet states that the text belongs to Bedâyi‛-i Belhî; however the identity of the author is disputed. It is also argued that the “Şerîf-i Şair,” whose name appears in the introduction to the text edited by Charles Schefer in his work entitled Chrestomathie Persane, is Ebû Şerîf Muhalledi-yi Gurgânî. Râhatü’l-insân has manuscripts in Turkish libraries. This article treats this work and its Turkish prose translation located at Süleymaniye Library, Fatih Section No. 5385 under the title “Pend-i Nûşîrevân-ı Âdil.” In this translation, the counsels written on the seventeen slices (küngüre of Nûşîrevân’s crown are given and it is told that this ruler had his crown put up somewhere appropriate every year for the soldiers to read his counsels. The purposes of Nûşîrevân’s counsels are proving a moral education to the public, directing his relations with his people as well as organizing the relations between them. Some of the counsels written on Nûşîrevân’s crown are as follows: “Respect the old and the weak, observe the rights of your parents, consult scholars before you do your business, have a command of your speech, do not betray trust, think before you speak.” The article will also treat some of the differences between the Persian manuscripts of the work and its Turkish translation. The transcription of the Turkish translation will be given. İslâmî edebiyatlarda Sasani hükümdarı Nûşîrevân’ın adaleti ve nasihatlarıyla ilgili birçok metin yazılmıştır. Bu metinlerden biri Fars Edebiyatı’nda onun tacının üzerinde yazılı olan nasihatları anlatan ve baz

  7. Operations Nougat and Whetstone events: Hard Hat, Danny Boy, Marshmallow, Mudpack, Wishbone, Gumdrop, Diluted Waters, and Tiny Tot, 15 February 1962-17 June 1965. Final report 15 Feb 62-19 Jun 68

    Energy Technology Data Exchange (ETDEWEB)

    Brady, W.J.; Horton, K.K.; Eubank, B.F.

    1984-01-31

    This report is a personnel oriented history of DOD participation in underground nuclear weapons testing during Operations NOUGAT and WHETSTONE, test events HARD HAT, DANNY BOY, MARSHMALLOW, MUDPACK, WISHBONE, GUMDROP, DILUTED WATERS, and TINY TOT. It is the first in a series of historical reports which will include all DOD underground nuclear weapons tests and DOE underground nuclear weapons tests with significant DOD participation from 1962 forward. In addition to these volumes presenting a history of the underground nuclear test program, a later restricted volume will identify all DOD participants, (military, civilian, and their contractors) and will list their dosimetry data.

  8. Sözden Yazıya, Yinelemeden Hatırlamaya, Ritüelden Estetiğe Devam Eden Anlatı / Narrative Continuing from Oral to Text, Repetition to Memory, Ritual to Aesthetics

    Directory of Open Access Journals (Sweden)

    M. Emir İlhan

    2017-04-01

    Full Text Available Abstract This study examines how a narrative transform from oral to text, repetition to memory and ritual to aesthetics. The study consists of three sections. In the first section; the questions about “what is the protected one?” and “what is the changed one?” in narration while a narration transforms to text will be discussed. In the second section, it is investigated that how "repetition" transformed to "remembering" in terms of memory, or in other words, how "symbolic" connotative recall transferred to "imaginary" thinkable remembering as the basic notion of oral culture. In the last section, the transition between symbolic and imaginary shown as they are actually the foundation of an evolution from aesthetic narrative to ritualistic words. Consequently, on contrary to the modern thoughts and thinkers which/who claim that the tension caused by the differentiation of ages is a “break”, the main purpose of this study is to show that it is not a “break” but “continuation”. The age difference of narration which occurs as a result of the difference between the word and writing/literacy; which is opposed to modernize the ideas and thinkers which handle this difference as a "break" may be seen as a "continuing". Öz Bu çalışmada, bir anlatının sözden yazıya, tekrardan hatırlamaya, ritüelden estetiğe nasıl bir dönüşüm geçirdiği ortaya konulmaktadır. Çalışmada, bir anlatının sözden yazıya geçerken tekrardan hatırlamaya doğru nasıl bir form değişikliğine uğradığı; bunun sonucu olarak da sözün yinelemeye dayalı ritüelistik formunun, yazıyla birlikte hatırlamayla oluşan bir estetik forma dönüştüğü ortaya konulacaktır. Çalışma üç bölümden oluşmaktadır. Birinci bölümde, sözden yazıya geçişte, “anlatıda korunan şey nedir?” ve “anlatıyla birlikte değişen şey nedir?”, sorusu irdelenecektir. Sözden yazıya, anlatıda devam eden form ve özün izlekleri ortaya

  9. Hatékony leadership magatartások szlovák szervezeti környezetben (Effective leadership behaviors in Slovak organizational environment – Introduction to the Slovak implict leadership theories –Results of the GLOBE research)

    OpenAIRE

    Bauer, Dávid

    2014-01-01

    Az itt bemutatott kutatás célja az volt, hogy azonosítsa és feltárja a szlovák vállalati környezetben követett és kívánatosnak tartott leadership dimenziókat és bemutassa azokat az implicit leadership elmélet alapján meghatározott magatartásokat, amelyek a sikeres leadershipet támogató magatartásokként jelennek meg (az implicit leadership elmélet szerint az egyének magatartásokhoz kapcsolódó hiedelmeik, meggyőződéseik és értékítéleteik alapján határozzák meg, kit tekintenek vezető...

  10. Enhanced B-Raf-mediated NRF2 gene transcription and HATs-mediated NRF2 protein acetylation contributes to ABCC1-mediated chemoresistance and glutathione-mediated survival in acquired topoisomerase II poison-resistant cancer cells.

    Science.gov (United States)

    Chen, Huang-Hui; Chang, Hsin-Huei; Chang, Jang-Yang; Tang, Ya-Chu; Cheng, Yung-Chi; Lin, Li-Mei; Cheng, Shu-Ying; Huang, Chih-Hsiang; Sun, Man-Wu; Chen, Chiung-Tong; Kuo, Ching-Chuan

    2017-12-01

    Nuclear factor erythroid-2-related factor 2 (NRF2) mainly regulates transcriptional activation through antioxidant-responsive elements (AREs) present in the promoters of NRF2 target genes. Recently, we found that NRF2 was overexpressed in a KB-derived drug-resistant cancer cell panel. In this panel, KB-7D cells, which show acquired resistance to topoisomerase II (Top II) poisons, exhibited the highest NRF2 activation. To investigate whether NRF2 directly contributed to acquired resistance against Top II poisons, we manipulated NRF2 by genetic and pharmacological approaches. The result demonstrated that silencing of NRF2 by RNA interference increased the sensitivity and treatment with NRF2 activator decreased the sensitivity of KB and KB-7D cells toward Top II poisons. Further, increased B-Raf-mediated NRF2 gene transcription and HATs-mediated NRF2 protein acetylation activated NRF2 signaling in KB-7D cells. Moreover, increased binding of NRF2 to an ARE in the promoter of ATP-binding cassette subfamily C member 1 (ABCC1) directly contributed to Top II poison resistance. In addition, activation of NRF2 increased glutathione level and antioxidant capacity in KB-7D cells compared with that in KB cells; moreover, high glutathione level provided survival advantage to KB-7D cells. Our study is the first to show that aberrant NRF2 activation is via increased B-Raf-mediated NRF2 gene transcription and HATs-mediated NRF2 protein acetylation, which increases the acquired resistance and promote the survival of Top II poison-resistant cancer cells. Importantly, NRF2 downstream effectors ABCC1 and glutathione directly contribute to acquired resistance and survival, respectively. These results suggest that blockade of NRF2 signaling may enhance therapeutic efficacy and reduce the survival of Top II poison-refractory tumors in clinical. Copyright © 2017 Elsevier Inc. All rights reserved.

  11. The Parameterization of Top-Hat Particle Sensors with Microchannel-Plate-Based Detection Systems and its Application to the Fast Plasma Investigation on NASA's Magnetospheric MultiScale Mission

    Science.gov (United States)

    Gershman, Daniel J.; Gliese, Ulrik; Dorelli, John C.; Avanov, Levon A.; Barrie, Alexander C.; Chornay, Dennis J.; MacDonald, Elizabeth A.; Holland, Matthew P.; Pollock, Craig J.

    2015-01-01

    The most common instrument for low energy plasmas consists of a top-hat electrostatic analyzer geometry coupled with a microchannel-plate (MCP)-based detection system. While the electrostatic optics for such sensors are readily simulated and parameterized during the laboratory calibration process, the detection system is often less well characterized. Furthermore, due to finite resources, for large sensor suites such as the Fast Plasma Investigation (FPI) on NASA's Magnetospheric Multiscale (MMS) mission, calibration data are increasingly sparse. Measurements must be interpolated and extrapolated to understand instrument behavior for untestable operating modes and yet sensor inter-calibration is critical to mission success. To characterize instruments from a minimal set of parameters we have developed the first comprehensive mathematical description of both sensor electrostatic optics and particle detection systems. We include effects of MCP efficiency, gain, scattering, capacitive crosstalk, and charge cloud spreading at the detector output. Our parameterization enables the interpolation and extrapolation of instrument response to all relevant particle energies, detector high voltage settings, and polar angles from a small set of calibration data. We apply this model to the 32 sensor heads in the Dual Electron Sensor (DES) and 32 sensor heads in the Dual Ion Sensor (DIS) instruments on the 4 MMS observatories and use least squares fitting of calibration data to extract all key instrument parameters. Parameters that will evolve in flight, namely MCP gain, will be determined daily through application of this model to specifically tailored in-flight calibration activities, providing a robust characterization of sensor suite performance throughout mission lifetime. Beyond FPI, our model provides a valuable framework for the simulation and evaluation of future detection system designs and can be used to maximize instrument understanding with minimal calibration

  12. SPITZER SECONDARY ECLIPSE DEPTHS WITH MULTIPLE INTRAPIXEL SENSITIVITY CORRECTION METHODS OBSERVATIONS OF WASP-13b, WASP-15b, WASP-16b, WASP-62b, AND HAT-P-22b

    Energy Technology Data Exchange (ETDEWEB)

    Kilpatrick, Brian M.; Tucker, Gregory S. [Department of Physics, Box 1843, Brown University, Providence, RI 02904 (United States); Lewis, Nikole K. [Space Telescope Science Institute, Baltimore, MD 21218 (United States); Kataria, Tiffany [Jet Propulsion Laboratory, California Institute of Technology, 4800 Oak Grove Drive, Pasadena, CA 91109 (United States); Deming, Drake [Department of Astronomy, University of Maryland, College Park, MD 20742 (United States); Ingalls, James G.; Krick, Jessica E., E-mail: brian_kilpatrick@brown.edu, E-mail: nlewis@stsci.org, E-mail: tiffany.kataria@jpl.nasa.gov, E-mail: ddeming@astro.umd.edu, E-mail: krick@ipac.caltech.edu [Spitzer Science Center, Infrared Processing and Analysis Center, California Institute of Technology, Mail Code 220-6, Pasadena, CA 91125 (United States)

    2017-01-01

    We measure the 4.5 μ m thermal emission of five transiting hot Jupiters, WASP-13b, WASP-15b, WASP-16b, WASP-62b, and HAT-P-22b using channel 2 of the Infrared Array Camera (IRAC) on the Spitzer Space Telescope . Significant intrapixel sensitivity variations in Spitzer IRAC data require careful correction in order to achieve precision on the order of several hundred parts per million (ppm) for the measurement of exoplanet secondary eclipses. We determine eclipse depths by first correcting the raw data using three independent data reduction methods. The Pixel Gain Map (PMAP), Nearest Neighbors (NNBR), and Pixel Level Decorrelation (PLD) each correct for the intrapixel sensitivity effect in Spitzer photometric time-series observations. The results from each methodology are compared against each other to establish if they reach a statistically equivalent result in every case and to evaluate their ability to minimize uncertainty in the measurement. We find that all three methods produce reliable results. For every planet examined here NNBR and PLD produce results that are in statistical agreement. However, the PMAP method appears to produce results in slight disagreement in cases where the stellar centroid is not kept consistently on the most well characterized area of the detector. We evaluate the ability of each method to reduce the scatter in the residuals as well as in the correlated noise in the corrected data. The NNBR and PLD methods consistently minimize both white and red noise levels and should be considered reliable and consistent. The planets in this study span equilibrium temperatures from 1100 to 2000 K and have brightness temperatures that require either high albedo or efficient recirculation. However, it is possible that other processes such as clouds or disequilibrium chemistry may also be responsible for producing these brightness temperatures.

  13. ALICE doffs hat to two companies

    CERN Multimedia

    2007-01-01

    During the fifth annual ALICE Industrial Awards ceremony, the ALICE Collaboration honoured two companies for their outstanding contributions to the construction of the experiment.For the past five years, the ALICE collaboration has been presenting its industrial partners with awards for meeting demanding or unusual requirements, for excellence in design or execution, for delivery on-time and on-budget and for outstanding cooperation. This year, on 9 March, ALICE presented awards to two companies for their exceptional performance. From left to right: Kees Oskamp (ALICE SSD), Arie de Haas (ALICE SSD), Gert-Jan Nooren (ALICE SSD), Shon Shmuel (FIBERNET), Yehuda Mor-Yosef (FIBERNET), Hans Boggild (ALICE), Jurgen Schukraft (ALICE Spokesperson), Catherine Decosse (ALICE) and Jean-Robert Lutz (ALICE SSD). FIBERNET Ltd., based in Yokneam, Israel, was rewarded for the excellent and timely assembly of the Silicon Strip Detector boards (SSD) of the Inner Tracking System with cable connections. Special low-mass cables, ...

  14. 'n Kritiese beskouing van HAT3

    African Journals Online (AJOL)

    definisies van subleksikale lemmas, in die besonder tegnostamme, gekritiseer word. Onder die 55 beginkomponente wat opgeneem is, word 38 as "woord- element(e)" beskryf, 5 word "voorvoegsel(s)" genoem (herni-, hiper-, hipo-, intro-, tele-), 6 word as "eerste lid van samestellings / woorde" beskryf (aero-,. R eprod u ced.

  15. Hats off to CERN's Master of Apprenticeships!

    CERN Multimedia

    2004-01-01

    Roland Gay of the HR Department (at right) recently received a special diploma from the Geneva Industrial Union (UIG). Presented by Carlo Lamprecht, Head of the Department of Economy, Employment and External Affairs of the State of Geneva, the diploma was awarded in recognition of the 199 CERN apprentices Roland has guided through the Certificat Fédéral de Capacité (CFC), an end-of-apprenticeship certificate awarded by the Cantonal authorities. Roland will be retiring in December 2004 after 37 years of service, 32 of which he spent in the role of apprenticeship supervisor.

  16. Die ganzen zahlen hat Gott gemacht

    Indian Academy of Sciences (India)

    primes in progression shows that the polynomial aX + b takes infinitely many prime values. In general, it may be very difficult to decide whether a given polynomial takes infinitely many prime values. For instance, it is not known if X2 + 1 represents infinitely many primes. Dirichlet proved that an arithmetic progression {ax +.

  17. Switching Hats: From Accessibility to Possibility

    Directory of Open Access Journals (Sweden)

    Sarah McGann

    2009-11-01

    Full Text Available Neil is a sporty, outdoorsy sort of bloke. He spends verylittle time at home, preferring to golf, surf, go to the footy and hang out with his mates: You can tell just by looking inside his house—a huge TV in the darkened lounge, and golf equipment, surf boards and motorbike gear fill up the room. That was before last October. Now, in June, Neil is a paraplegic, his house is inaccessible and his boys-toys are in the way. For Neil, his home, previously an inwardly focused place to sleep and store, will become the centre of his world (when he can eventually get into it. Initially, accessibility is the key problem to be solved. To this end the architectural advisor from the rehabilitation unit proposed formulaic adjustments to the bathroom to allow for wheelchair access. However, accessibility is only one facet of the problem. This environment, relatively unimportant before,now needs to enable and inspire the occupant both physically and emotionally. As physical abilities dramatically change the spatial practices of everyday life also change.The home environment is ever more important to support and help heal emotional scarring after a life-changing event.In the context of shorter hospital and rehabilitation stays,the home provides a vital extension to the healthcare system. Therefore it is important that architectural advice given to enable this move considers the holistic qualities ofdesign thinking rather than be restricted to short-term solutions.

  18. Hats off to the particle suppliers

    CERN Multimedia

    Rolf Heuer

    2010-01-01

    A couple of weeks into the LHC’s first high energy physics run, and we’ve already got an impressive story to tell. Long fills for physics are becoming routine, luminosity scans have increased the collision rate. The operators are becoming adept at squeezing the beams ever smaller, and higher intensity studies are progressing well. With the experiments, it’s the same story.   Following the plots that the spokespersons were able to show on 30 March after just one hour of running, the experiments have already made significant inroads into re-measuring all the Standard Model parameters necessary to ensure that they fully understand their detectors before any new discoveries can be announced. It’s impressive stuff, and the attention is rightly on the LHC and its experiments. But we shouldn’t lose sight of the fact that all this relies on the seamless operation of many other systems. Starting from a deceptively simple bottle of hydrogen, an LHC proton ...

  19. Verbreitung rassistischen Gedankenguts – Meinungsfreiheit hat Grenzen

    Directory of Open Access Journals (Sweden)

    Hendrik Cremer

    2017-12-01

    Full Text Available Die Meinungsfreiheit ist ein zentrales Menschenrecht, das – so formuliert es das Bundesverfassungsgericht – für die freiheitlich-demokratische Staatsordnung „schlechthin konstituierend“ ist. Die Meinungsfreiheit ist jedoch kein Freifahrtschein für rassistische Diffamierungen und Parolen. Dies ergibt sich aus der grund- und menschenrechtlichen Schutzpflicht des Staates, die Bevölkerung vor rassistischer Propaganda zu schützen.

  20. Wer hat Recht? Who Has Legal Rights?

    Directory of Open Access Journals (Sweden)

    Swantje Lichtenstein

    2004-07-01

    Full Text Available Der Zusammenhang zwischen sexueller Differenz und deren juristischen Folgen wird in der Wiener Studie näher beleuchtet. Auch wenn die Zeiten der offenen Diskriminierung vorüber zu sein scheinen, die Ungleichheit vor dem Recht bleibt bestehen. Noch immer liegen die Verdienste von Frauen deutlich unter denen von Männern, immer noch wird – auch gesetzlich – der Bereich des Privaten als genuin weiblicher verstanden, die Öffentlichkeit dagegen ist männlich. Hier setzen die Fragen zur gerechten Machtverteilung an, die der Band behandelt. Die Interdependenz von gesellschaftlicher Veränderung und rechtlichem Wandel wird von Elisabeth Holzleithner anhand verschiedener Diskurse vorgeführt.The connection between sexual difference and its juridicial consequences is examined more closely in this Viennese study. Even when the times of open discrimination seem to have subsided, inequality in the legal sphere still remains. Women’s incomes are still distinctly below those of men. The private sphere is still understood—also legally—as being genuinely feminine, whereas the public sphere is considered masculine. The questions considered in the volume regarding the just distribution of power stem from these issues. The interdependence of societal change and legal transformation is presented by Elisabeth Holzleithner on the basis of various discourses.

  1. Getting started with Red Hat Enterprise virtualization

    CERN Document Server

    Subramanian, Pradeep

    2014-01-01

    If you are a system administrator who is interested in implementing and managing open source virtualization infrastructures, this is the book for you. A basic knowledge of virtualization and basic Linux command line experience is needed.

  2. Computer Security: White hats for CERN

    CERN Multimedia

    Stefan Lueders, Computer Security Team

    2016-01-01

    CERN is under attack. Permanently. Even right now. In particular, the CERN web environment, with its thousands of websites and millions of webpages, is a popular target for evil-doers as well as for security researchers.   Usually, their attacks are unsuccessful and fade away over time. Sometimes, however, they are successful and manage to break into a CERN website or web server… It is imperative that we learn about our weaknesses before others do – and fix them! Hackers with bad intentions are usually named “black hats” as they misuse their power to cause destruction or downtime via any weakness they can find. “Grey hats” are more moderate and might just have some fun with the weaknesses they find, for example by putting naked teddy bears or a personal message (such as “I hacked U”) on the compromised website. Last but not least, “white hats” report their findings directly to us and suggest that...

  3. Jede Nation hat eben ihre eigen Wahrheit

    Czech Academy of Sciences Publication Activity Database

    Stach, Stephan

    Č. 118 (2016), s. 13 ISSN 0174-4909 R&D Projects: GA ČR(CZ) GJ16-01775Y Institutional support: RVO:68378114 Keywords : politics of memory * Museum of the Second World War * Poland Subject RIV: AB - History

  4. Hats for Sale: A Salute to Directors.

    Science.gov (United States)

    Ferguson, Sue

    Experiences related to pursuing excellence and a positive attitude as a campus childcare director are presented. The paper describes the emotional quotient (EQ) as a complex, multifaceted quality incorporating self- and social-awareness, empathy, optimism, and persistence that may predict one's success in certain kinds of work. Optimism may be…

  5. Hatékonyság növelése tervezéssel - avagy: aggregált tervezés alkalmazása egy magyar vállalatnál = Improving efficiency with production planning - Applying aggregate planning at a Hungarian company

    OpenAIRE

    Gelei, Andrea; Pálfi, József; Dobos, Imre

    2009-01-01

    A cikk alapvető kérdése, hogy miképpen használható a tervezés a termelési folyamatok, s ezzel a vállalati m}uködés egészének hatékonyságnövelése érdekében. A termeléstervezés szintjei és eszközei közül a középtávú aggregált tervezésre koncentrálunk. Ennek oka elsősorban az, hogy tapasztalatunk szerinte tervezési szint gyakorlati alkalmazása még nem tekinthető elterjedtnek, s ebből következően az eszköz alaposabb ismerete és alkalmazásának elterjedése jelentős tartalékokat tárhat fel a m...

  6. Big Hat, No Cattle: Managing Human Resources, Part 1.

    Science.gov (United States)

    Skinner, Wickham

    1982-01-01

    Presents an in-depth analysis of problems and a suggested approach to developing human resources which goes beyond identifying symptoms and provides a comprehensive perspective for building an effective work force. (JOW)

  7. Middle School Girls Sample "Hard Hat" Life at Construction Camp

    Science.gov (United States)

    Brown, Aneeta

    2013-01-01

    On a Monday morning in July, a fan as tall as a refrigerator churned noisily in the cavernous classroom. As the outdoor temperature crept higher, teenage girls wearing hardhats and safety glasses wiped perspiration and sawdust from their faces. This was not a field trip. This was the second hour of camp at Ranken Technical College in St. Louis,…

  8. Welches Geschlecht hat die Avantgarde? Which gender has the Avantgarde?

    Directory of Open Access Journals (Sweden)

    Gertrud Lehnert

    2000-07-01

    Full Text Available Das Buch betrachtet das Theater der französischen und amerikanischen ‚Avantgarde‘ der Moderne und Postmoderne unter dem Aspekt des Geschlechts: Welcher Verfahren bedient sich avantgardistische Kunst, ist avantgardistische Kunst in geschlechtlicher Hinsicht restriktiv, oder ermöglicht sie die subversive feministische oder auch lesbisch-schwule Ausformung spezifischer Formen?In this book the French and American avantgarde theatre of the modern and postmodern period is analysed from aspects of gender. The questions raised are which processes serve to develop avantgarde art, whether avantgarde art is restrictive with regard to gender, or whether it enables a subversive feminist or specific lesbian/gay forms of theatre?

  9. Hard-Hat Detection for Construction Safety Visualization

    OpenAIRE

    Shrestha, Kishor; Shrestha, Pramen P.; Bajracharya, Dinesh; Yfantis, Evangelos A.

    2015-01-01

    In 2012, 775 fatalities were recorded, and many more were injured at construction sites in the United States. Of these, 415 fatalities (54%) were due to fall, slips, and trips as well as being struck by falling objects. In order to decrease fatalities at construction sites to these types of events, the Occupational Safety and Health Administration (OSHA) provides Fall Prevention and OSHA-10 trainings to construction workers. Moreover, safety personnel monitor whether the workers use personal ...

  10. The White-hat Bot: A Novel Botnet Defense Strategy

    Science.gov (United States)

    2012-06-14

    WHB Yes nodeH BlackEnergy Bot WHB Yes nodeI BlackEnergy Bot WHB Yes nodeJ Sample Bot CC WHB Yes nodeK Sample Bot WHB Yes nodeL Sample Bot WHB Yes...Bot nodeC Sample Bot nodeD nodeE nodeF nodeG BlackEnergy Bot Sample Bot Torpig Bot Torpig CC nodeH nodeI nodeJ

  11. Computer Security: Join the CERN WhiteHat Challenge!

    CERN Multimedia

    Computer Security Team

    2014-01-01

    Over the past couple of months, several CERN users have reported vulnerabilities they have found in computing services and servers running at CERN. All were relevant, many were interesting and a few even surprising. Spotting weaknesses and areas for improvement before malicious people can exploit them is paramount. It helps protect the operation of our accelerators and experiments as well as the reputation of the Organization. Therefore, we would like to express our gratitude to those people for having reported these weaknesses! Great job and well done!   Seizing the opportunity, we would like to reopen the hunt for bugs, vulnerabilities and insecure configurations of CERN applications, websites and devices. You might recall we ran a similar initiative (“Hide & Seek”) in 2012 where we asked you to sift through CERN’s webpages and send us those that hold sensitive and confidential information. Quite a number of juicy documents were found and subsequently remov...

  12. Ambush marketing. A case of the Heineken Bullhorn hat

    NARCIS (Netherlands)

    Jan de Leeuw

    2006-01-01

    Een definitie van Ambush marketing is: "de verzameling van activiteiten van een organisatie die zich niet officieel als sponsor aan een ander organisatie heeft verbonden, maar via haar marketingactiviteiten wel doet voorkomen dat deze relatie bestaat." In feite probeert de organisatie bij de

  13. Veils, Caps and Hats: The Language of Headgear between the ...

    African Journals Online (AJOL)

    L'autrice tratta l'uso del copricapo nel Medievo e all'inizio dell'Età moderna, con continui riferimenti ai testi di San Paolo e alle prediche quattrocentesche dei frati minori dell'osservanza francescana. Viene altresì considerato l'impiego della mantellina, del velo e del piumaggio, tipiche della moda del tempo, in relazione alle ...

  14. Black Hats and White Hats: The Effect of Organizational Culture and Institutional Identity on the Twenty-third Air Force

    Science.gov (United States)

    2006-12-01

    an ex- amination of CSAR and AFSOF culture suggests that humans are more important than hardware. But in accordance with the Air Force measurement of...that “[an Army artilleryman’s] pride is in the art of laying a battery of guns for accurate fire. The kind of gun . . . is inci- dental ; the power...Army and Air Force cemented a symbiotic partnership that dictated their force-structure initiatives in the 1980s due to the Soviet threat, as well

  15. Black Hats and White Hats: The Effect of Organizational Culture and Institutional Identity on the Twenty-third Air Force

    National Research Council Canada - National Science Library

    Koskinas, Ioannis

    2006-01-01

    .... Although brief, the Twenty-third Air Force's experience provides sufficient data for a thorough analysis of the effect of organizational culture and institutional agendas on the evolution of a nascent organization...

  16. Extremely high prevalence of multi-resistance among uropathogens ...

    African Journals Online (AJOL)

    Extremely high prevalence of multi-resistance among uropathogens from hospitalised children in Beira, Mozambique. BT van der Meeren, KD Chhaganlal, A Pfeiffer, E Gomez, JJ Ferro, M Hilbink, C Macome, FJ van der Vondervoort, K Steidel, PC Wever ...

  17. South African Medical Journal - Vol 103, No 6 (2013)

    African Journals Online (AJOL)

    Extremely high prevalence of multi-resistance among uropathogens from hospitalised children in Beira, Mozambique · EMAIL FREE FULL TEXT EMAIL FREE FULL TEXT · DOWNLOAD FULL TEXT DOWNLOAD FULL TEXT. BT van der Meeren, KD Chhaganlal, A Pfeiffer, E Gomez, JJ Ferro, M Hilbink, C Macome, FJ van ...

  18. Cortical control of generalized absence seizures: effects of lidocaine applied to the somatosensory cortex in wag/rij rats

    NARCIS (Netherlands)

    Sitnikova, E.Y.; Luijtelaar, E.L.J.M. van; Luijtelaar, E.L.J.M. van; Kuznetsova, G.D.; Coenen, A.M.L.; Chepurnov, S.A.

    2004-01-01

    In the WAG/Rij rat strain, a genetic model of absence epilepsy, generalized spike-wave discharges (SWDs) are initiated in a specific area of the somatosensory cortex and quickly spread over the cortex and thalamus. This cortical focus regarded as a "leading" spot, driving SWDs (Meeren et al., J.

  19. The problem of low variance voxels in statistical parametric mapping; a new hat avoids a 'haircut'.

    Science.gov (United States)

    Ridgway, Gerard R; Litvak, Vladimir; Flandin, Guillaume; Friston, Karl J; Penny, Will D

    2012-02-01

    Statistical parametric mapping (SPM) locates significant clusters based on a ratio of signal to noise (a 'contrast' of the parameters divided by its standard error) meaning that very low noise regions, for example outside the brain, can attain artefactually high statistical values. Similarly, the commonly applied preprocessing step of Gaussian spatial smoothing can shift the peak statistical significance away from the peak of the contrast and towards regions of lower variance. These problems have previously been identified in positron emission tomography (PET) (Reimold et al., 2006) and voxel-based morphometry (VBM) (Acosta-Cabronero et al., 2008), but can also appear in functional magnetic resonance imaging (fMRI) studies. Additionally, for source-reconstructed magneto- and electro-encephalography (M/EEG), the problems are particularly severe because sparsity-favouring priors constrain meaningfully large signal and variance to a small set of compactly supported regions within the brain. (Acosta-Cabronero et al., 2008) suggested adding noise to background voxels (the 'haircut'), effectively increasing their noise variance, but at the cost of contaminating neighbouring regions with the added noise once smoothed. Following theory and simulations, we propose to modify--directly and solely--the noise variance estimate, and investigate this solution on real imaging data from a range of modalities. Copyright © 2011 Elsevier Inc. All rights reserved.

  20. Deciphering the Fluorine Code-The Many Hats Fluorine Wears in a Protein Environment.

    Science.gov (United States)

    Berger, Allison Ann; Völler, Jan-Stefan; Budisa, Nediljko; Koksch, Beate

    2017-09-19

    Deciphering the fluorine code is how we describe not only the focus of this Account, but also the systematic approach to studying the impact of fluorine's incorporation on the properties of peptides and proteins used by our groups and others. The introduction of fluorine has been shown to impart favorable, but seldom predictable, properties to peptides and proteins, but up until about two decades ago the outcomes of fluorine modification of peptides and proteins were largely left to chance. Driven by the motivation to extend the application of the unique properties of the element fluorine from medicinal and agro chemistry to peptide and protein engineering we have established extensive research programs that enable the systematic investigation of effects that accompany the introduction of fluorine into this class of biopolymers. The introduction of fluorine into amino acids offers a universe of options for modifications with regard to number and position of fluorine substituents in the amino acid side chain. Moreover, it is important to emphasize that the consequences of incorporating the C-F bond into a biopolymer can be attributed to two distinct yet related phenomena: (i) the fluorine substituent can directly engage in intermolecular interactions with its environment and/or (ii) the other functional groups present in the molecule can be influenced by the electron withdrawing nature of this element (intramolecular) and in turn interact differently with their immediate environment (intermolecular). Based on our studies, we have shown that a change in number and/or position of as subtle as one single fluorine substituent has the power to considerably modify key properties of amino acids such as hydrophobicity, polarity, and secondary structure propensity. These properties are crucial factors in peptide and protein engineering, and thus, fluorinated amino acids can be applied to fine-tune properties such as protein folding, proteolytic stability, and protein-protein interactions provided we understand and become able to predict the outcome of a fluorine substitution in this context. With this Account, we attempt to analyze information we gained from our recent projects on how the nature of the fluorine atom and C-F bond influence four key properties of peptides and proteins: peptide folding, protein-protein interactions, ribosomal translation, and protease stability. These results impressively show why the introduction of fluorine creates a new class of amino acids with a repertoire of functionalities that is unique to the world of proteins and in some cases orthogonal to the set of canonical and natural amino acids. Our concluding statements aim to offer a few conserved design principles that have emerged from systematic studies over the last two decades; in this way, we hope to advance the field of peptide and protein engineering based on the judicious introduction of fluorinated building blocks.

  1. The Cohen and Kuttel Stories: Is the Place Where I Hang my Hat Still ...

    African Journals Online (AJOL)

    The two key cases in South African jurisprudence that are cited whenever the question of residence or ordinary residence is raised are Cohen v CIR and CIR v Kuttel. These cases form the foundation of this article as they examine the meaning of “resident” and “ordinary” resident” in the modern milieu. The article provides ...

  2. "Jeder Mensch hat einen Name": Legal and Ethical Dimensions of Human Experiments under National Socialism.

    Science.gov (United States)

    This paper considers whether it is right to identify by name victims of experiments abused either for psychiatric research, or for other types of experimentation in psychiatric hospitals and institutions. Similar questions arise as to whether it is possible to identify any of the persons for whom brains and other body parts were held for medical research and teaching.

  3. "...dass man einen festen Glauben daran hat, dass das jetzige System die Rettung sei"

    DEFF Research Database (Denmark)

    Lammers, Karl Christian

    2011-01-01

    Undersøgelse af den danske gesandt i Berlin Herluf Zahles beretning om og vurdering af forholdet mellem Hitler og tyskerne.......Undersøgelse af den danske gesandt i Berlin Herluf Zahles beretning om og vurdering af forholdet mellem Hitler og tyskerne....

  4. The Epidemiology of Childhood Asthma in Red Deer and Medicine Hat, Alberta

    Directory of Open Access Journals (Sweden)

    Patrick A Hessel

    2001-01-01

    Full Text Available OBJECTIVES: To document the prevalence of asthma among school-aged children in two Alberta communities, to understand host and indoor environmental factors associated with asthma, and to compare these factors between the two communities.

  5. ZB MED: Welchen Stellenwert hat die bibliothekarische Infrastruktur für die Wissenschaft?

    Directory of Open Access Journals (Sweden)

    Brintzinger, Klaus-Rainer

    2016-09-01

    Full Text Available This article deals with the expected effects of the recommendation of the senate of the Leibniz Association to the Joint Science Conference to stop the co-funding of ZB MED – Leibniz Information Centre for Life Sciences by federal and state authorities. Until the founding of the Leibniz Association servicing as a specialized library for medicine had been ZB MED’s main task, while evaluation was done under scientific perspectives. The now suspected close-down of this indispensable national information agency would do great harm and damage to medical literature und information supply throughout Germany. For this reason the Association of German Librarians took initiatives for ZB MED’s persistence.

  6. Visual structure analysis of compound reliefs of milli hats used by ...

    African Journals Online (AJOL)

    The major part of Kurdish arts has been traditionally created by women. These women have inherited old distant memories generations after generations and will also leave them as inheritance to succeeding generations. The most significant of these arts is the art of knitting which bears significant importance amongst ...

  7. Commodity Cluster Computing for Remote Sensing Applications using Red Hat LINUX

    Science.gov (United States)

    Dorband, John

    2003-01-01

    Since 1994, we have been doing research at Goddard Space Flight Center on implementing a wide variety of applications on commodity based computing clusters. This talk is about these clusters and haw they are used on these applications including ones for remote sensing.

  8. "Tied together like a woven hat:" Protective pathways to Alaska native sobriety

    Directory of Open Access Journals (Sweden)

    Mohatt Gerald V

    2004-11-01

    Full Text Available Abstract Background The People Awakening Project (1RO1 AA 11446-03 had two purposes, completed in Phase I and Phase II of the project. The purpose of Phase I was to complete a qualitative study; the research objective was discovery oriented with the specific aim of identification of protective and recovery factors in Alaska Native sobriety. Results were used to develop a heuristic model of protective and recovery factors, and measures based on these factors. The research objective of Phase II was to pilot these measures and provide initial validity data. Methods Phase I utilized a life history methodology. People Awakening interviewed a convenience sample of 101 Alaska Natives who had either recovered from alcoholism (n = 58 or never had a drinking problem (n = 43. This later group included both lifetime abstainers (LAs and non-problem drinkers (NPs. Life histories were transcribed and analyzed using grounded theory and consensual data analytic procedures within a participatory action research framework. Analyses were utilized to generate heuristic models of protection and recovery from alcohol abuse among Alaska Natives. Results Analyses generated a heuristic model of protective factors from alcohol abuse. The resulting multilevel and multi-factorial model describes interactive and reciprocal influences of (a individual, family, and community characteristics; (b trauma and the individual and contextual response to trauma, (c experimental substance use and the person's social environment; and (d reflective processes associated with a turning point, or a life decision regarding sobriety. The importance of cultural factors mediating all these protective processes is emphasized. For NPs, the resilience process drew from personal stores of self-confidence, self-efficacy, and self-mastery that derived from ability to successfully maneuver within stressful or potentially traumatizing environments. In contrast, for many LAs, efficacy was instead described in more socially embedded terms better understood as communal mastery. One style of mastery is more associated with individualistic orientations, the other with more collectivistic. Future research is needed regarding the generalizeability of this group difference. Conclusions Results suggest that preventative interventions should focus on intervening simultaneously at the community, family, and individual levels to build resilience and protective factors at each level. Of particular importance is the building of reflexivity along with other cognitive processes that allow the individual to think through problems and to reach a life decision to not abuse alcohol.

  9. Hatefulle ytringer. Delrapport 2: Forskning på hat og diskriminering

    OpenAIRE

    Eggebø, Helga; Stubberud, Elisabeth

    2016-01-01

    De siste årene har hatefulle ytringer blitt aktualisert som et viktig demokratisk spørsmål på den offentlige og politiske dagsordenen. Likevel finnes det foreløpig lite forskningsbasert kunnskap om hatefulle ytringer i norsk sammenheng. Denne rapporten har som formål å samle, oppsummere og vurdere forskning som belyser sammenhengen mellom hatefulle ytringer og diskriminering, mobbing og vold på den ene siden, og forskning om konsekvenser for samfunnet og for de gruppene som er utsatt på den a...

  10. The TopHat experiment: A balloon-borne instrument for mapping millimeter and submillimeter emission

    DEFF Research Database (Denmark)

    Silverberg, R.F.; Cheng, E.S.; Aguirre, J.E.

    2005-01-01

    from 175 to 630 GHz. The telescope was a compact, 1 m, on-axis Cassegrain telescope designed to scan the sky at a fixed elevation of 78 degrees. The radiometer used cryogenic bolometers coupled to a single feed horn via a dichroic filter system. The observing strategy was intended to efficiently cover...

  11. CALLIGRAPHY OF STACKED FRUIT IN ART OF CALLIGRAPHY / HAT SANATINDA MEYVE ISTIFLI HATLAR

    Directory of Open Access Journals (Sweden)

    Dr. Zübeyde Cihan ÖZSAYINER

    2008-10-01

    Full Text Available Calligraphy with stacked fruit in the art ofcalligraphy In Turkish culture fruit has created afundamental element used lovingly in architecture,calligraphy, miniatures, woodwork, metalwork, porcelain art, carpets, towels, edging, printed cloth, embroidery,folk art and gravestones. As a result of studies, it hasbeen shown that fruit has the symbolic meanings ofimmortality, the existence that is the core of something, ajewel and truth. It is seen that the symbolisms of fruit byitself changes according to societies. The apple becamethe fruit of the tree in paradise and the “golden apple” isthe symbol of immortality. The grape symbolizes autumn,the pomegranate bountifulness, reproduction, maternityand birth. As a result of my research in the art ofcalligraphy it has been proven that there are manuscriptsreflecting religious and mystic subjects have beenstacked neatly in the forms of pears, apples andpomegranate. In the Turkish Foundation CalligraphicArts Museum, the only such one in Turkey and in theworld there are three examples of calligraphy neatlystacked in pear form. It seems that the stacked fruit inthe form of pears, apples and pomegranates and writtenin various techniques were lovingly used by calligrapherswho had great creative power, sought change in theTurkish art of calligraphy and worked in religious andmystic circles.

  12. Decommissioning. Success with preparation; Mit kompetenten Mitarbeitern gelingt der Rueckbau. Erfolg hat, wer darauf vorbereitet ist

    Energy Technology Data Exchange (ETDEWEB)

    Klasen, Joerg [ENBW Kernkraft GmbH, Neckarwestheim (Germany); Schulz, Rolf [Rolf Schulz HR Consultants AG, Baden-Baden (Germany); Wilhelm, Oliver

    2017-02-15

    The decommissioning of a nuclear power plant poses a significant challenge for the operating company. The business model is turned upside down and a working culture developed for power operation has to be adapted while necessary know- how for the upcoming tasks has to be built up. The trauma for the employees induced by the final plant shut-down has to be considered and respected. The change of working culture in the enterprise has to be managed and the organization has to be prepared for the future. Here the methods of Change-Management offer a systematic and effective approach. Confidence in the employee's competencies is one of the key success factors for the change into the future.

  13. Measurement of the diffractive structure function in deep inelastic scattering hat HERA

    International Nuclear Information System (INIS)

    Derrick, M.; Krakauer, D.; Magill, S.

    1995-05-01

    This paper presents an analysis of the inclusive properties of diffractive deep inelastic scattering events produced in ep interactions at HERA. The events are characterised by a rapidity gap between the outgoing proton system and the remaining hadronic system. Inclusive distributions are presented and compared with Monte Carlo models for diffractive processes. The data are consistent with models where the pomeron structure function has a hard and a soft contribution. The diffractive structure function is measured as a function of x IP , the momentum fraction lost by the proton, of β, the momentum fraction of the struck quark with respect to x IP , and of Q 2 . The x IP dependence is consistent with the form (1/x IP ) a where a=1.30-±0.80(stat) -0.14 +0.08 (sys) in all bins of βand Q 2 . In the measured Q 2 range, the diffractive structure function approximately scales with Q 2 at fixed β. In an Ingelman-Schlein type model, where commonly used pomeron flux factor normalisations are assumed, it is found that the quarks within the pomeron do not saturate the momentum sum rule. (orig.)

  14. Stimulation of cytolytic T lymphocytes by azaguanine-resistant mouse tumor cells in selective hat medium

    International Nuclear Information System (INIS)

    Snick, J. van; Uyttenhove, C.; Pel, A. van; Boon, T.

    1981-01-01

    Primed syngeneic or umprimed allogeneic mouse spleen cells were stimulated with azaguanine-resistant P815 tumor cells that were killed by the addition of aminopterin to the stimulation medium. The recovery of lymphocytes and their cytolytic activity and specificity were similar to those obtained after stimulation with irradiated cells. This method conveniently replaces the inactivation of stimulatory cells by irradiation or mitomycin treatment. Moreover, it has the advantage of inactivating not only the stimulatory cells but also the tumor cells that often contaminate the spleens of tumor-bearing animals, provided these animals have been inoculated with azaguanine-resistant tumor cell mutants. (Auth.)

  15. Cylinders out of a top hat: counts-in-cells for projected densities

    Science.gov (United States)

    Uhlemann, Cora; Pichon, Christophe; Codis, Sandrine; L'Huillier, Benjamin; Kim, Juhan; Bernardeau, Francis; Park, Changbom; Prunet, Simon

    2018-03-01

    Large deviation statistics is implemented to predict the statistics of cosmic densities in cylinders applicable to photometric surveys. It yields few percent accurate analytical predictions for the one-point probability distribution function (PDF) of densities in concentric or compensated cylinders; and also captures the density-dependence of their angular clustering (cylinder bias). All predictions are found to be in excellent agreement with the cosmological simulation Horizon Run 4 in the quasi-linear regime where standard perturbation theory normally breaks down. These results are combined with a simple local bias model that relates dark matter and tracer densities in cylinders and validated on simulated halo catalogues. This formalism can be used to probe cosmology with existing and upcoming photometric surveys like DES, Euclid or WFIRST containing billions of galaxies.

  16. Basic Business and Economics: Did You Throw Your Hat in the Arena?

    Science.gov (United States)

    Scriven, Jolene D.

    1977-01-01

    The author suggests that teachers of basic business and economics need to be involved in introducing current social and political issues in the classroom. If teachers encourage students to critically examine issues it should improve students' decision making skills and make classes more exciting and challenging. (HD)

  17. „Strenger Geschmack hat bei uns keine Freunde”. Griechenland in der deutschen Werbung

    OpenAIRE

    Reimann, Sandra

    2016-01-01

    Den im Band präsentierten Beiträgen liegt sowohl theoretisch als auch empirisch eine medienlinguistische Perspektive in der Betrachtung gegenwärtiger gesellschaftspolitischer Ereignisse in Deutschland und Polen, die in letzter Zeit viele kontroverse Debatten hervorgerufen haben, zugrunde. Die gezeigten unterschiedlichen Möglichkeiten der Vernetzung linguistischer und medienorientierter Forschungen resultieren deshalb aus der Überzeugung, dass die Medien die Welt der Politik auf ihre Art inter...

  18. Hat sich das Gehirn beim Haushunde, im Vergleich mit Wildhundarten, vergrössert, oder verkleinert

    NARCIS (Netherlands)

    Dubois, Eug.

    1922-01-01

    In dem inhaltreichen Buche „Der Mensch. Sein Ursprung und seine Entwicklung” von W. LECHE ¹) finden sich die sehr merkwürdigen Abbildungen zweier „Skeletten von nahezu derselben Grösse, das eine von einem zahmen Hund, das andere von einer wilden Hundeart”, nach der Meinung des Autors „schlagende

  19. Indigenous Knowledge in the Life Sciences Classroom: Put on Your de Bono Hats!

    Science.gov (United States)

    de Beer, Josef; Whitlock, Elrina

    2009-01-01

    The whole world was united in its condemnation of the pre-1994 apartheid regime in South Africa. Apartheid meant that many South Africans were robbed of their democratic voices and cultural identities. In this article, the authors pose the question: Are you guilty of "knowledge apartheid" in your biology classroom? Does every student have a voice…

  20. "Die Nato hat einen grossen Fehler begangen" / Toomas Hendrik Ilves ; interv. Ansgar Graw

    Index Scriptorium Estoniae

    Ilves, Toomas Hendrik, 1953-

    2008-01-01

    Eesti president räägib sõjalistest kokkupõrgetest Gruusias, vajadusest uue rahvusvahelise julgeolekustruktuuri järele, ootustest rahvusvahelise üldsuse suhtes, Balti riikide julgeolekust ning kritiseerib NATO otsust mitte anda Gruusiale NATO liikmelisuse tegevuskava

  1. Moccasins into Slippers: Woodlands Indian Hats, Bags, and Shoes in Tradition and Transformation.

    Science.gov (United States)

    Phillips, Ruth B.

    1990-01-01

    In the mid-nineteenth century, an abrupt transformation occurred in textiles and other art forms of northeastern Woodlands Indians. Trade, tourism, and survival needs sparked changes in materials used and garment types produced, as well as substitution of a new vocabulary of floral imagery for "pagan" iconographic traditions. (SV)

  2. hat is the Relationship between Entrepreneurship and Unemployment in Visegrad Countries?

    Directory of Open Access Journals (Sweden)

    Ondrej Dvoulety

    2017-06-01

    Full Text Available The presented study aims to quantify the determinants of entrepreneurship in the four countries of the Visegrad (V4 group (the Czech Republic, Hungary, Poland and Slovakia with a particular focus on the relationship between entrepreneurship and unemployment. The purpose of the research was to analyze whether, during the periods of higher unemployment rate, individuals more likely engage into entrepreneurial activity. Data were collected from the national statistical offices of the Visegrad countries, World Bank, Eurostat and Heritage Foundation. The collected sample covered years 1998-2015. To achieve the main objective of the article, regression models with the dependent variable, the rate of registered businesses per economically active inhabitant, were quantified. Estimated regressions proved a positive relationship between entrepreneurship and unemployment. A higher unemployment rate was associated with the increase in overall entrepreneurial activity. Estimated models further confirmed the negative influence of the administrative barriers on the overall entrepreneurial activity. Several policy and research implications are discussed in the study.

  3. Corked Hats and "Coronation Street": British and New Zealand Children's Imaginative Geographies of the Other.

    Science.gov (United States)

    Holloway, Sarah L.; Valentine, Gill

    2000-01-01

    Explores the ways British and New Zealand children imagined each other's environments and cultures. Illustrates the sources and importance of stereotypical understandings of landscape, people, and patterns of daily life in other nations, and the ways these may be contested through Internet contact. (JPB)

  4. Hat das humane Wachtumshormon (hGH eine Relevanz in der Kontrolle der penilen Erektion?

    Directory of Open Access Journals (Sweden)

    Ückert St

    2003-01-01

    Full Text Available Allgemeines: Schon seit langem wird die Frage einer Beteiligung des Hypophysenhormons Human Growth Hormone (Wachstumshormon, hGH, GH an der Kontrolle der sexuellen Maturation und der Reproduktionsfunktion des Menschen diskutiert. Die Symptome eines GH-Defizits beim Mann sind u. a. allgemeine Antriebslosigkeit, Oligo- oder Azoospermie, eine Verminderung der Libido sowie eine Beeinträchtigung der normalen Erektionsfähigkeit. Es wird vermutet, daß die biologischen Effekte des GH eine durch das Somatomedin Insulin-like Growth Factor 1 (IGF-1 vermittelte Stimulation der Produktion von Stickoxid (NO durch die endotheliale und neuronale Form des Enzyms NO-Synthase einschließen. So konnte gezeigt werden, daß physiologische Konzentrationen von GH den adrenergen Tonus isolierter Streifenpräparate humaner Schwellkörpermuskulatur antagonisieren und den Gewebegehalt des Second Messengers cGMP erhöhen. Im Rahmen dieser Studie haben wir in einem Kollektiv gesunder Männer und in einer Gruppe von Patienten mit erektiler Dysfunktion (ED die systemischen und cavernösen Serumkonzentrationen von GH während verschiedener peniler Funktionszustände, d. h. verschiedener Stadien der sexuellen Erregung, untersucht. Methoden: 35 gesunden männlichen Probanden und 45 Patienten mit einer ED organogener oder psychogener Genese wurden während der penilen Flakzidität, Tumeszenz, Rigidität - dieses Stadium wurde nur von den Gesunden erreicht - und Detumeszenz zeitgleich Blutproben aus einer Cubitalvene und dem Corpus cavernosum penis entnommen. Tumeszenz und Rigidität wurden durch visuelle und taktile Stimulation ausgelöst. Die Quantifizierung von GH in Aliquots der Serumfraktionen erfolgte mit immunradiometrischen Methoden (IRMA. Ergebnisse: In der Gruppe der gesunden Männer stieg die mittlere systemische und cavernöse Serumkonzentration von GH während der Tumeszenz an, während in den Phasen der Rigidität und Detumeszenz eine Abnahme registriert wurde. Eine Unterteilung des Patientenkollektivs nach einer psychogenen und organogenen Genese der ED ergab, daß die mittleren GH-Konzentrationen im Blut der psychogenen Patienten in den Stadien der Flakzidität, Tumeszenz und Detumeszenz sich nicht wesentlich von denen im Serum der gesunden Männer unterschieden. Die GH-Spiegel im systemischen und cavernösen Blut der organogenen Patienten waren nicht nur deutlich erniedrigt, auch eine Erhöhung der mittleren GH-Serumkonzentration während der penilen Tumeszenz wurde nur in geringem Maße registriert. Schlußfolgerung: Unsere Resultate lassen vermuten, daß dem GH wahrscheinlich eine zentrale Rolle in der Aufrechterhaltung der erektilen Funktion zukommt und daß eine Störung der normalen GH-Sekretion zur Manifestation einer ED beitragen kann.

  5. Score a Facilities Hat Trick: Strategic Goals for Successful Hiring, Training, and Team Commitment

    Science.gov (United States)

    Loy, Darcy

    2012-01-01

    Granted, it might be a bit of a stretch to find comparable attributes between an ice hockey team and facilities management organizations. However, if you are open-minded to the possibility and begin to analyze each of these entities, you will find there are some distinct similarities. Ice hockey is a fast-paced and ever-changing game, much like a…

  6. Clare Soper's Hat: New Education Fellowship Correspondence between Bloomsbury and New Zealand, 1938-1946

    Science.gov (United States)

    Middleton, Sue

    2013-01-01

    Broadening horizons beyond nations, transnational histories trace global flows connecting people and places. Historians have studied the New Education Fellowship (NEF) as a global network. Focused within the nation, research on New Zealand's involvement with NEF has emphasised how its activities before the Second World War impacted on the Labour…

  7. Evaluation of histone deacetylase inhibitors (HDACi) as therapeutic leads for human African trypanosomiasis (HAT).

    Science.gov (United States)

    Carrillo, Angela K; Guiguemde, W Armand; Guy, R Kiplin

    2015-08-15

    Two of the histone deacetylases, TbDAC1 and TbDAC3, have been reported to be essential genes in trypanosomes. Therefore, we tested the activity of a panel of human histone deacetylase inhibitors (HDACi) for their ability to block proliferation of Trypanosoma brucei brucei. Among the HDACi's, the hydroxamic acid derivatives panobinostat and belinostat exhibited potency that appeared to make them viable candidates for development due to their reported pharmacokinetic characteristics. However, cellular pharmacodynamic analysis demonstrated that these drugs were unable to kill cultured parasites at exposures seen in patients at their tolerated doses and additionally failed to show any synergistic effects in combination with pentamidine, suramin, melarsoprol, or nifurtimox. Analysis of the potency of the entire HDACi panel revealed no correlations between potency against any human HDAC isoform and inhibition of T. brucei proliferation, suggesting that the trypanosome histone deacetylases possess a unique specificity. These studies confirmed that HDAC inhibitors have potential as leads against human African trypanosomiasis but that none of the current clinical candidates can be directly repurposed. Therefore, development of HDACi's with appropriate specificity and potency may be a viable route to a new class of anti-trypanosomal drugs. Copyright © 2014 Elsevier Ltd. All rights reserved.

  8. CAT in the HAT: catabolic inhibition by the histone acetyltransferase GCN5.

    Science.gov (United States)

    Liu, Yi; Montminy, Marc

    2006-06-01

    The nuclear hormone receptor coactivator PGC-1alpha is a key regulator of gluconeogenic genes during fasting. In this issue of Cell Metabolism, Puigserver and colleagues (Lerin et al., 2006) report that the histone acetyltransferase GCN5 inhibits gluconeogenesis by acetylating and sequestering PGC-1alpha in nuclear foci.

  9. Am I Wearing the Right Hat? Navigating Professional Relationships between Parent-Teachers and Their Colleagues

    Science.gov (United States)

    Lipsky, Eliana; Friedman, Ilana Dvorin; Harkema, Rebecca

    2017-01-01

    Utilizing organizational role theory and cognitive role theory as a theoretical framework, this phenomenological study examined the experience of parent-teachers and colleague-teachers in small educational settings and their perceptions of these dynamic relationships and potential areas of conflict. Findings highlighted perceived strengths, yet…

  10. Ma e to ca hat hav nihot e ssava ve und escul

    African Journals Online (AJOL)

    SAM

    CBSD, and it is likely that natural selection has occurred in areas of high disease pressure. 'Nachinyaya' was identified in 1995 from southern Tanzania (Thresh, 2003) with delayed onset of necrosis (Hillocks, 2003). Recently, screening of germplasm has been extended to. Mozambique, Kenya, Uganda and Tanzania, but ...

  11. Shear dominated failure in the 'hat' specimen from the 2013 Sandia Fracture Challenge.

    Energy Technology Data Exchange (ETDEWEB)

    Corona, Edmundo [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)

    2016-11-01

    The objective of this memo is to present a brief report of the progress achieved during FY2016 on the investigation of ductile failure in the 2013 Sandia Fracture Challenge specimen. It is a follow-up to the results of an experimental investigation presented in [1]. The experi- mental investigation was conducted with both the original steel A286 material used in the fracture challenge as well as with Al 7075-T651. The new results include further microscopy work for the steel A286 specimens, failure criterion veri cation for both materials and the implementation of a nite element model containing `material imperfections' to simulate the limit load in the response of the steel A286 specimens. Funding used to conduct the work presented here was provided by the ASC V&V program on validation of shear failure (Benjamin Reedlunn, PI) and from Sandia's LDRD program. This memo assumes that the reader is familiar with the material in [1].

  12. Shear dominated failure in the 'hat' specimen from the 2013 Sandia Fracture Challenge.

    Energy Technology Data Exchange (ETDEWEB)

    Corona, Edmundo [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)

    2016-11-01

    The objective of this memo is to present a brief report of the progress achieved during FY2016 on the investigation of ductile failure in the 2013 Sandia Fracture Challenge specimen. The experimental investigation was conducted with both the original steel A286 material used in the fracture challenge as well as with Al 7075-T651. The new results include further microscopy work for the steel A286 specimens, failure criterion verification for both materials and the implementation of a finite element model containing `material imperfections' to simulate the limit load in the response of the steel A286 specimens. Funding used to conduct the work presented here was provided by the ASC V&V program on validation of shear failure (Benjamin Reedlunn, PI) and from Sandia's LDRD program.

  13. Adoption of open source software in business models: a Red Hat and IBM case study

    CSIR Research Space (South Africa)

    Munga, N

    2009-10-01

    Full Text Available beyond those of customer demand. Linux provided it with a common set of APIs across its entire product line, providing a unified architecture for software developers. IBM refocused on targeting its traditional large corporate customers, and the need... and its position in the market identified [15]. Various types of business models are discussed in the literature. Rappa [16], using the customer relationship as the primary dimension, defines the brokerage model, information intermediary model...

  14. White hats or Don Quixotes? Human rights vigilantes in the global economy

    OpenAIRE

    Kimberly Ann Elliot; Richard B. Freeman

    2004-01-01

    With the continuing expansion of global economic integration, labor standards in developing countries have become a hot button issue. One result has been a proliferation of efforts to use the market to put pressure directly on multinational corporations to improve wages and working conditions in their overseas operations and to insist that their suppliers do so as well. This paper analyzes the dynamics of these efforts in terms of a 'market for standards' in which consumers, stimulated by hum...

  15. HAT: Hypergeometric Analysis of Tiling-arrays with application to promoter-GeneChip data

    NARCIS (Netherlands)

    E. Taskesen (Erdogan); R. Beekman (Renée); J. de Ridder (Jeroen); B.J. Wouters (Bas); J. Peeters (Justine); I.P. Touw (Ivo); M.J.T. Reinders (Marcel); H.R. Delwel (Ruud)

    2010-01-01

    textabstractBackground: Tiling-arrays are applicable to multiple types of biological research questions. Due to its advantages (high sensitivity, resolution, unbiased), the technology is often employed in genome-wide investigations. A major challenge in the analysis of tiling-array data is to define

  16. HAT : Hypergeometric Analysis of Tiling-arrays with application to promoter-GeneChip data

    NARCIS (Netherlands)

    Taskesen, E.; Beekman, R.; De Ridder, J.; Wouters, B.J.; Peeters, J.K.; Touw, I.P.; Reinders, M.J.T.; Delwel, R.

    2010-01-01

    Background: Tiling-arrays are applicable to multiple types of biological research questions. Due to its advantages (high sensitivity, resolution, unbiased), the technology is often employed in genome-wide investigations. A major challenge in the analysis of tiling-array data is to define

  17. The rabbit in the hat: dubious argumentation and the persuasive effects of prescription drug advertising (DTCA).

    Science.gov (United States)

    Rubinelli, Sara; Nakamoto, Kent; Schulz, Peter J

    2008-01-01

    There is an ongoing global debate over the potential benefits and risks of allowing direct-to-consumer advertising of prescription medicines (DTCA). The core of this debate concerns the identification of DTCA either as a beneficial procedure to be promoted or as a damaging procedure to be abolished. Economic data on DTCA suggest that this form of advertising has an impact on consumers. Based on this premise, we explore the use of argumentation theory to inquire into the reasons for this success. In particular, by combining perspectives from argumentation theory and marketing research this paper aims to test the hypothesis of whether DTCA presents information framed in potentially misleading, but persuasive, argumentative structures. We highlight and discuss the results of two studies designed to assess whether readers perceive DTCA as argumentative and, if so, which explicit and implicit elements provide groundings for the inference that consumers draw from the ads. The analysis highlights the presence in DTCA of dubious arguments (fallacies and distracting claims) that may go unnoticed. Also, it illustrates the nature of readers' wrong assumptions that arise independently from the contents of the ads. These factors seem to influence the level of the self-perceived persuasiveness of DTCA.

  18. Aging Trajectories in Different Body Systems Share Common Environmental Etiology : The Healthy Aging Twin Study (HATS)

    NARCIS (Netherlands)

    Moayyeri, Alireza; Hart, Deborah J.; Snieder, Harold; Hammond, Christopher J.; Spector, Timothy D.; Steves, Claire J.

    Little is known about the extent to which aging trajectories of different body systems share common sources of variance. We here present a large twin study investigating the trajectories of change in five systems: cardiovascular, respiratory, skeletal, morphometric, and metabolic. Longitudinal

  19. DSM-IV und DSM-5: Was hat sich tatsächlich verändert?

    OpenAIRE

    Ehret, Anna M.; Berking, Matthias

    2013-01-01

    Im Mai 2013 ist die fünfte Auflage des Diagnostischen und Statistischen Manuals Psychischer Störungen (DSM-5) der American Psychiatric Association erschienen. Um die Vor- und Nachteile des DSM-5 beurteilen und gegebenenfalls in Forschung und Praxis angemessen berücksichtigen zu können, sollten Wissenschaftler und Praktiker gleichermaßen über die Änderungen gegenüber dem DSM-IV informiert sein. In diesem Beitrag werden die wesentlichen Unterschiede zwischen dem DSM-IV und DSM-5 beschrieben. Ze...

  20. "Hats off, gentlemen, to our Australian mothers!" Representations of white femininity in North Queensland in the early twentieth century.

    Science.gov (United States)

    Henningham, N

    2001-01-01

    This paper examines some representations of the anxiety and uncertainty about "white woman's place" in tropical North Queensland that were present in medical and general discourse in the early twentieth century. It focuses on white women's work in the private sphere as both the source of and the solution to these anxieties. Although 'White Australia' had been legislatively established in the "public sphere" by the 1920s, through the passage of the Queensland Aboriginal Protection Act of 1897, and the Commonwealth Immigration Restriction Act of 1901, in the tropics there was still public concern about how it would be established in the "private sphere". This was because even though the conventional wisdom that a white man could not work in the tropics and remain healthy had been successfully challenged by the early twentieth century, the same could not be said about such wisdom as it applied to white women and children. This paper looks at some of the ways that ideologies of race and gender intersected in the early twentieth century to construct white women and children as a group that could bring down the successful establishment of "White Australia", and this group was specially targeted for surveillance by the "new experts" of medicine, sociology and domestic science.

  1. A new hat for librarians: providing REDCap support to establish the library as a central data hub.

    Science.gov (United States)

    Read, Kevin; LaPolla, Fred Willie Zametkin

    2018-01-01

    REDCap, an electronic data capture tool, supports good research data management, but many researchers lack familiarity with the tool. While a REDCap administrator provided technical support and a clinical data management support unit provided study design support, a service gap existed. Librarians with REDCap expertise sought to increase and improve usage through outreach, workshops, and consultations. In collaboration with a REDCap administrator and the director of the clinical data management support unit, the role of the library was established in providing REDCap training and consultations. REDCap trainings were offered to the medical center during the library's quarterly data series, which served as a springboard for offering tailored REDCap support to researchers and research groups. Providing REDCap support has proved to be an effective way to associate the library with data-related activities in an academic medical center and identify new opportunities for offering data services in the library. By offering REDCap services, the library established strong partnerships with the Information Technology Department, Clinical Data Support Department, and Compliance Office by filling in training gaps, while simultaneously referring users back to these departments when additional expertise was required. These new partnerships continue to grow and serve to position the library as a central data hub in the institution.

  2. Diabetes and obesity are significant risk factors for morning hypertension: from Ibaraki Hypertension Assessment Trial (I-HAT).

    Science.gov (United States)

    Toyama, Masahiro; Watanabe, Shigeyuki; Miyauchi, Takashi; Kuroda, Yasuhisa; Ojima, Eiji; Sato, Akira; Seo, Yoshihiro; Aonuma, Kazutaka

    2014-05-28

    Although morning hypertension (HT) has been identified as a major cardiovascular risk, susceptible populations remain unknown. This study aimed to clarify the relationship between morning HT and diabetes or obesity in a large-scale population. Clinic blood pressure (BP) and BP upon awakening were recorded in 2554 outpatients with HT who attended 101 clinics or hospitals for two weeks. Mean clinic and awakening BP>140/90 and >135/85 mmHg, respectively, were considered as HT. The patients were classified according to values for clinic and home BP, into normal BP, white coat HT, masked HT, and sustained HT. Morning BP (mmHg) significantly and progressively elevated in the order of normal glucose tolerance, impaired glucose tolerance and diabetes (134.1 ± 12.2, 135.4 ± 13.1 and 137.5 ± 11.5; pmorning HT significantly increased and progressively in the same order (53.4%, 55.6%, 66.4%, pMorning BP was significantly higher among obese patients with diabetes than among non-obese and non-diabetic patients (138.8 ± 10.5, 133.1 ± 11.9, pmorning HT was significantly higher in obese diabetic patients than in non-obese and non-diabetic patients (73.0% vs. 49.9%, pmorning HT. Copyright © 2014 Elsevier Inc. All rights reserved.

  3. Square-Toed Boots and Felt Hats: Irish Revolutionaries and the Invasion of Canada (1848-1871

    Directory of Open Access Journals (Sweden)

    Marta Ramón-García

    2010-03-01

    Full Text Available The Fenian movement was born in 1858 as an alliance between the Irish Republican Brotherhood, a revolutionary secret society, and the Fenian Brotherhood, an Irish-American organisation intended to supply this society with funds and trained officers. This was not the first time that Irish nationalists on both sides of the Atlantic had tried to cooperate, but it was the first time that there was a steady arrangement in place. The Fenian partnership was extremely successful on the surface, but it was undermined by fundamental differences in customs, political attitudes and ultimate goals between Irish and American Fenians. The clearest evidence of these differences was afforded by the Fenian Brotherhood’s successive attempts to invade Canada between 1866 and 1871. As military episodes the Canadian raids were negligible; as Irish revolutionary attempts they seem absurd. However, they were a perfectly coherent manifestation of the Irish-American “hyphenated identity”. The present article traces the parallel evolution of the Irish Republican Brotherhood and the Fenian Brotherhood up to 1866, and reconstructs the cultural and political reasons for the revival of the Canadian scheme, the ensuing split in the Fenian Brotherhood, and the final collapse of the Fenian alliance.

  4. Knowledge, behaviours, practices and beliefs regarding Human African Trypanosomiasis (HAT) among inhabitants of Kinshasa (Democratic Republic of Congo).

    Science.gov (United States)

    Tshimungu, Kandolo; Kalambayi, Barthélemy Banza; Kiyombo, Mbela; Okenge, Léon Ngongo; Mol, Patrick De

    2008-01-01

    In Kinshasa, an average of less than 50 new cases of Human African Trypanosomiasis was notified, per year, between 1969 and 1995. The situation of endemic sleeping sickness suddenly worsened in 1996 with 254 new cases identified thanks to passive detection. No study dealing with conceptions relative to sleeping sickness was ever listed to date. The objective of this study was to determine the level of knowledge, behaviours, practices and local beliefs about sleeping sickness among residents of the endemic zone of Kinshasa. The investigation relied on a case/control study. We used a quantitative and qualitative methodology (structured questionnaire and focus on discussion groups). Case-patients were people affected by trypanosomiasis between the 1st of January 2004 and the 31st of December 2005 and who registered to the National Human African Trypanosomiasis Program (PNLTHA-RDC). Controls were seronegative residents. The case/control ratio was of 1/2. A total of 437 case-patients and 874 controls were included in the study. Level of knowledge of elementary concepts about trypanosomiasis was low among case-patients (44%). The proportion of participants with a low level of education was more important in the group of case-patients (40%) than in the control group (25.6%). The supernatural origin of trypanosomiasis was evoked such as divine, sorcery and transgression of rules. Many respondents (31.4%) call on churches for help when they are not satisfied with the health centre where first therapeutic aid is provided. An important proportion of people who participated to the study (87%) were in favour of a passive detection. After testing the degree of statistical significance, several variables appeared to be determining factors for the acquisition of knowledge of Human African Trypanosomiasis in the city of Kinshasa: education level (elevated: 81%, low: 19%; p age (> or =20 years old: 89.9%, old: 10.1%; p fight against trypanosomiasis. Beliefs and practices of Kinshasa's inhabitants (coming from their conceptions) also stand in the way of plans meant to fight the disease. It is necessary to improve the knowledge of preventive strategies and to fight social prejudice and false beliefs by informing and educating populations.

  5. Evaluation of Contact Heat Transfer Coefficient and Phase Transformation during Hot Stamping of a Hat-Type Part

    Science.gov (United States)

    Kim, Heung-Kyu; Lee, Seong Hyeon; Choi, Hyunjoo

    2015-01-01

    Using an inverse analysis technique, the heat transfer coefficient on the die-workpiece contact surface of a hot stamping process was evaluated as a power law function of contact pressure. This evaluation was to determine whether the heat transfer coefficient on the contact surface could be used for finite element analysis of the entire hot stamping process. By comparing results of the finite element analysis and experimental measurements of the phase transformation, an evaluation was performed to determine whether the obtained heat transfer coefficient function could provide reasonable finite element prediction for workpiece properties affected by the hot stamping process. PMID:28788046

  6. Schreiben hat auch eine Stimme. Eine explorative Untersuchung über die Beziehung zwischen lautem Sprechen und Schreiben.

    OpenAIRE

    Lohmeier-Weidner, Yvonne (B. A.)

    2017-01-01

    Die Aufgabe in dieser Arbeit ist die Untersuchung der Beziehung zwischen lautem Sprechen und Schreiben im Schreibprozess. Grundlage ist die Annahme, dass beides zusammengehört und das Verbalisieren von Gedanken zum Schreiben, ob im Dialog oder im Selbstgespräch, selbiges positiv unterstützt. Dazu werden drei Studentinnen der Universität Paderborn, die an einem Abschlussarbeitenworkshop des Kompetenzzentrums Schreiben teilnahmen, durch ein fokussiertes Interview befragt. Diese Interviews werde...

  7. In vitro antioxidant capacity of tea of Echinodorus grandiforus, “leather hat,” in Wistar rat liver

    Directory of Open Access Journals (Sweden)

    RAFAELA F. LUNARDI

    2014-09-01

    Full Text Available Oxidative stress has been considered as one of the factors responsible for hepatic diseases, which sometimes require new ways of treatment. The present study aimed to evaluate the in vitro antioxidant capacity of the tea of Echinodorus grandiforus (“leather hat” plant in rat liver. Different preparations of tea were evaluated for phenolic composition, antioxidant activity by DPPH assay and ability to inhibit lipid peroxidation induced by copper sulfate. The antioxidant activity was assessed in liver tissue treated with sodium azide in the presence or absence of tea by assays for lipid peroxidation (TBARS, protein oxidation (carbonyl and the antioxidant enzymes catalase (CAT and superoxide dismutase (SOD. The results show that different preparations of tea are important sources of polyphenols and contain theobromine, catechin and vitexin. Furthermore, the results indicate that this tea exhibits an antioxidant activity by its ability to scavenge DPPH radical. Different preparations of tea prevented damage to lipids and proteins induced by sodium azide, as well as assisting in restoring CAT and SOD activities. Thus, it can be seen that E. grandiforus tea had antioxidant activity in serum and liver being able to prevent oxidative damages generated by sodium azide.

  8. Sulfonamides as new hydrogen atom transfer (HAT) catalysts for photoredox allylic and benzylic C-H arylations.

    Science.gov (United States)

    Tanaka, Hirotaka; Sakai, Kentaro; Kawamura, Atsushi; Oisaki, Kounosuke; Kanai, Motomu

    2018-02-02

    A catalytic amount of a sterically and electronically tuned diarylsulfonamide promoted allylic and benzylic C-H arylations in cooperation with a visible light photoredox catalyst. This is the first example of the catalytic use of a sulfonamidyl radical to promote the hydrogen atom transfer process.

  9. Heat transfer in a couple stress fluid over a continuous moving surface with internal hat generation and convective boundary conditions

    Energy Technology Data Exchange (ETDEWEB)

    Hayat, Tasawar [Quaid-i-Azam Univ., Islamabad (Pakistan). Dept. of Mathematics; King Saud Univ., Riyadh (Saudi Arabia). Dept. of Physics; Iqbal, Zahid [Quaid-i-Azam Univ., Islamabad (Pakistan). Dept. of Mathematics; Qasim, Muhammad [COMSATS Institute of Information Technology (CIIT), Islamabad (Pakistan). Dept. of Mathematics; Aldossary, Omar M. [King Saud Univ., Riyadh (Saudi Arabia). Dept. of Physics

    2012-05-15

    This investigation reports the boundary layer flow and heat transfer characteristics in a couple stress fluid flow over a continuos moving surface with a parallel free stream. The effects of heat generation in the presence of convective boundary conditions are also investigated. Series solutions for the velocity and temperature distributions are obtained by the homotopy analysis method (HAM). Convergence of obtained series solutions are analyzed. The results are obtained and discussed through graphs for physical parameters of interest. (orig.)

  10. Wann und wo hat die große Rezession die Unterstützung der Demokratie unterminiert?

    NARCIS (Netherlands)

    Pennings, Paul

    2017-01-01

    It is likely that ten years of economic crisis have eroded the support of democracy in Europe. But how much? The existing research is divided on this issue. Some claim that the degree of satisfaction with democracy has declined across the whole of Europe during the Great Recession. Other researchers

  11. The development of a practical tool for risk assessment of manual work – the HAT-tool

    NARCIS (Netherlands)

    Kraker, H. de; Douwes, M.

    2008-01-01

    For the Dutch Ministry of Social Affairs and Employment we developed a tool to assess the risks of developing complaints of the arm, neck or shoulders during manual work. The tool was developed for every type of organization and is easy to use, does not require measurements other than time and can

  12. Effect of Web Assisted Education Supported by Six Thinking Hats on Students' Academic Achievement in Science and Technology Classes

    Science.gov (United States)

    Ercan, Orhan; Bilen, Kadir

    2014-01-01

    Advances in computer technologies and adoption of related methods and techniques in education have developed parallel to each other. This study focuses on the need to utilize more than one teaching method and technique in education rather than focusing on a single teaching method. By using the pre-test post-test and control group semi-experimental…

  13. Purple Boas, Lesbian Affection, and John Deere Hats: Teacher Educators' Role in Addressing Homophobia in Secondary Schools

    Science.gov (United States)

    Jones, Joseph R.

    2014-01-01

    This article examines how one group of teachers discussed their perceptions of homophobia in their schools. A qualitative study was conducted that utilized the following: individual and group interviews, participant reflective journals, professional development sessions, and a research journal. The study illuminated how the role of hegemonic…

  14. Selective Hydrogen Atom Abstraction via Induced Bond Polarization: The Direct -Arylation of Alcohols via Photoredox, HAT and Nickel Catalysis.

    Science.gov (United States)

    Twilton, Jack; Christensen, Melodie; DiRocco, Daniel A; Ruck, Rebecca T; Davies, Ian W; MacMillan, David William

    2018-02-28

    The combination of nickel metallaphotoredox catalysis, hydrogen atom transfer catalysis, and a Lewis acid activation mode, has led to the development of an arylation protocol for the selective functionalization of alcohol -hydroxy C-H bonds. This approach employs zinc-mediated alcohol deprotonation to activate -hydroxy C-H bonds while simultaneously suppressing C-O bond formation by inhibiting formation of nickel alkoxide species. The use of Zn based Lewis acids also deactivates other hydridic bonds such as -amino and -oxy C-H bonds. This technology facilitates rapid access to benzylic alcohols, an important motif in drug discovery. A 3-step synthesis of the Prozac exemplifies the utility of this new method. © 2018 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  15. Gümnaasiumis õppivad venekeelsed noored / Margarita Kazjulja, Jelena Helemäe, Aida Hatšaturjan

    Index Scriptorium Estoniae

    Kazjulja, Margarita, 1961-

    2013-01-01

    Uuringu raames toimunud rühmaintervjuudes otsiti vastuseid küsimustele, millisteks peetakse vene keelsete gümnaasiumis õppivate noorte haridusalaseid perspektiive ja millisteks hinnatakse venekeelsete noorte lõimumisperspektiive

  16. Yeast Sgf73/Ataxin-7 serves to anchor the deubiquitination module into both SAGA and Slik(SALSA HAT complexes

    Directory of Open Access Journals (Sweden)

    Lee Kenneth K

    2009-02-01

    Full Text Available Abstract Spinocerebellar ataxia (SCA is a physically devastating, genetically inherited disorder characterized by abnormal brain function that results in the progressive loss of the ability to coordinate movements. There are many types of SCAs as there are various gene mutations that can cause this disease. SCA types 1–3, 6–10, 12, and 17 result from a trinucleotide repeat expansion in the DNA-coding sequence. Intriguingly, recent work has demonstrated that increased trinucleotde expansions in the SCA7 gene result in defect in the function of the SAGA histone acetyltransferase complex. The SCA7 gene encodes a subunit of the SAGA complex. This subunit is conserved in yeast as the SGF73 gene. We demonstrate that Sgf73 is required to recruit the histone deubiquitination module into both SAGA and the related SliK(SALSA complex, and to maintain levels of histone ubiquitination, which is necessary for regulation of transcription at a number of genes.

  17. Calcium in pollen-pistil interaction in `Petunia hybrida Hat`. Pt. 3. Localization of Ca{sup 2+} ions and Ca{sup 2+}-ATPase in pollinated pistil

    Energy Technology Data Exchange (ETDEWEB)

    Bednarska, E.; Butowt, R. [Uniwersytet Mikolaja Kopernika, Torun (Poland)

    1995-12-31

    Studies were carried out of Ca{sup 2+} and Ca{sup 2+}-ATPase localization in pollinated (6 and 48 h after pollination) pistils of `Petunia hybrida`. The results were confronted with Ca{sup 2+} localization in mature pollen grain and in unpollinated pistil. It has been found that after pollination the number of Ca{sup 2+} sequestered in the stigmal exudate and in the sporoderm of the pollen grain gets lower. That phenomenon was associated with the appearance of a large number of Sb/Ca precipitates in the submembrane cytoplasm of the germinating pollen. In the vacuolized pollen grain, i.e. grown into a pollen tube, there were only a few precipitates. In the pollen tube, Ca{sup 2+} were found in the organelles of the tip cytoplasm and in the external pectin cell wall. Studies with the use of {sup 45}Ca{sup 2+} have revealed that the source of calcium ions incorporated into the pollen tube tip and its pectin wall is the transmitting tract of the style. In the transmitting tract overgrown with pollen tubes, Ca{sup 2+} were localized in the intercellular matrix and in the transmitting cell. Sb/Ca precipitates occurred in the nuclei, around the secretary vesicles and on the plasmalemma in the transverse walls region. Elevated Ca{sup 2+} level was found in degenerating cells (inhibited pollen tubes, transmitting cells, nucellar cells). The progressing degeneration process of the cells of the transmitting tract of the pollinated pistil was associated with a decrease in the activity of plasmalemma Ca{sup 2+}-ATPase. (author). 30 refs, 19 figs.

  18. Environmental radioactivity monitoring. 30 years after Chernobyl - what has changed?; Ueberwachung der Umweltradioaktivitaet. 30 Jahre nach Tschernobyl. Was hat sich veraendert?

    Energy Technology Data Exchange (ETDEWEB)

    Bieringer, Jacqueline [Bundesamt fuer Strahlenschutz, Freiburg (Germany). Fachgebiet SW 2.5; Steinkopff, Thomas [Deutscher Wetterdienst, Offenbach (Germany); Wershofen, Herbert [Physikalisch-Technische Bundesanstalt, Braunschweig (Germany). Lab. 6.301

    2016-05-01

    Since the 50ies environmental radiation monitoring was assigned to federal and federal state authorities with respect to radionuclide releases from USSR and US nuclear weapon tests. First fallout measurements were performed since 1953 at the measuring point Schauinsland by the University Freiburg. In consequence of the obligations form the Euratom treaty 1957 and the increasing civil nuclear power utilization the radiation monitoring was extended and legally regulated.

  19. More than one rabbit out of the hat: Radiation, transgenic and symbiont-based approaches for sustainable management of mosquito and tsetse fly populations

    International Nuclear Information System (INIS)

    Bourtzis, K.; Lees, R.S.; Hendrichs, J.; Vreysen, M.J.B.

    2016-01-01

    Mosquitoes (Diptera: Culicidae) and tsetse flies (Diptera: Glossinidae) are bloodsucking vectors of human and animal pathogens. Mosquito-borne diseases (malaria, filariasis, dengue, chikungunya and Zika) cause severe mortality and morbidity annually, and tsetse fly-borne diseases (African trypanosomes causing sleeping sickness in humans and nagana in livestock) cost Sub-Saharan Africa an estimated US$ 4750 million annually. Current reliance on insecticides for vector control is unsustainable: due to increasing insecticide resistance and growing concerns about health and environmental impacts of chemical control there is a growing need for novel, effective and safe biologically- based methods that are more sustainable. The integration of the sterile insect technique has proven successful to manage crop pests and disease vectors, particularly tsetse flies, and is likely to prove effective against mosquito vectors, particularly once sexseparation methods are improved. Transgenic and symbiont-based approaches are in development, and more advanced in (particularly Aedes) mosquitoes than in tsetse flies; however, issues around stability, sustainability and biosecurity have to be addressed, especially when considering population replacement approaches. Regulatory issues and those relating to intellectual property and economic cost of application must also be overcome. Standardised methods to assess insect quality are required to compare and predict efficacy of the different approaches. Different combinations of these three approaches could be integrated to maximise their benefits, and all have the potential to be used in tsetse and mosquito area-wide integrated pest management programmes. (author)

  20. What are the consequences of the reactor accident in Fukushima for the evaluation of nuclear risk?; Welche Folgen hat der Kernkraftwerksunfall in Fukushima fuer die Bewertung von Kernenergierisiken?

    Energy Technology Data Exchange (ETDEWEB)

    Renn, Ortwin [Univ. Stuttgart (Germany). Inst. Sozialwissenshaften V; Gallego Carrera, Diana [Univ. Stuttgart (Germany). ZIRIUS Zentrum fuer Interdiszipliaere Risiko- und Innovationsforschung

    2015-06-01

    There are historical breaks in the relation of risk analysis, risk perception and regulation policy. The year 2011 with the reactor accident in the NPP Fukushima was such a break, especially in Germany. The nuclear phase-out was reduced to ten years the energy policy turnaround received a broad societal agreement. Nuclear facilities loose public acceptance, the risk perception has changed. The Japanese evaluation results on faulty and nontransparent behavior and the lack of governance of responsible persons and authorities including a poor accident management have further decreased the public confidence. A new concept of safety culture for all nuclear facilities including the radioactive waste management is required, the communication processes between plant operator, authorities, science and the public have to be intensified.

  1. Mating and memory: an educational primer for use with "epigenetic control of learning and memory in Drosophila by Tip60 HAT action".

    Science.gov (United States)

    Schmidt, Rebecca L; Sheeley, Sara L

    2015-05-01

    An article by Xu et al. in the December 2014 issue of GENETICS can be used to illustrate epigenetic modification of gene expression, reverse genetic manipulation, genetic/epigenetic influence on behavioral studies, and studies using the Drosophila model organism applied to human disease. This Primer provides background information; technical explanations of genetic, biochemical, and behavioral approaches from the study; and an example of an approach for classroom use with discussion questions to aid in student comprehension of the research article. Copyright © 2015 by the Genetics Society of America.

  2. Hats off to CERN's Master of Apprenticeships ! Roland Gay of the HR Department (at right) recently received a special diploma from the Geneva Industrial Union (UIG).

    CERN Multimedia

    2004-01-01

    Presented by Carlo Lamprecht, Head of the Department of Economy, Employment and External Affairs of the State of Geneva, the diploma was awarded in recognition of the 199 CERN apprentices Roland has guided through the Certificat Fédéral de Capacité (CFC), an end-of-apprenticeship certificate awarded by the Cantonal authorities. Roland will be retiring in December 2004 after 37 years of service, 32 of which he spent in the role of apprenticeship supervisor.

  3. Limitations of Short Range Mexican Hat Connection for Driving Target Selection in a 2D Neural Field: Activity Suppression and Deviation from Input Stimuli.

    Directory of Open Access Journals (Sweden)

    Geoffrey eMégardon

    2015-10-01

    Full Text Available Dynamic Neural Field models (DNF often use a kernel of connection with short range excitation and long range inhibition. This organization has been suggested as a model for brain structures or for artificial systems involved in winner-take-all processes such as saliency localisation, perceptual decision or target/action selection. A good example of such a DNF is the superior colliculus (SC, a key structure for eye movements. Recent results suggest that the superficial layers of the SC (SCs exhibit relatively short range inhibition with a longer time constant than excitation. The aim of the present study was to further examine the properties of a DNF with such an inhibition pattern in the context of target selection. First we tested the effects of stimulus size and shape on when and where self-maintained clusters of firing neurons appeared, using three variants of the model. In each model variant, small stimuli led to rapid formation of a spiking cluster, a range of medium sizes led to the suppression of any activity on the network and hence to no target selection, while larger sizes led to delayed selection of multiple loci. Second, we tested the model with two stimuli separated by a varying distance. Again single, none, or multiple spiking clusters could occur, depending on distance and relative stimulus strength. For short distances, activity attracted towards the strongest stimulus, reminiscent of well-known behavioural data for saccadic eye movements, while for larger distances repulsion away from the second stimulus occurred. All these properties predicted by the model suggest that the SCs, or any other neural structure thought to implement a short range MH, is an imperfect winner-take-all system. Although those properties call for systematic testing, the discussion gathers neurophysiological and behavioural data suggesting that such properties are indeed present in target selection for saccadic eye movements.

  4. »... daß einem leid tut, wie er aufgehört hat, deutsch zu sein« Alexander von Humboldt, Preußen und Amerika

    Directory of Open Access Journals (Sweden)

    Ottmar Ette

    2002-04-01

    Full Text Available Article in German, Abstract in English.Within the context of the recent "Prussia Tricentennial 2001", this paper encourages a different view of Prussia by offering a new look on the writings and activities of one of its most famous citizens, Alexander von Humboldt. Starting with the traditional (and problematic image of Prussia focussed on the Hohenzollern and, above all, Friedrich II, it highlights the problems between Prussian and German historiography on one side, and the author of "Cosmos" and his world-wide prestige on the other. Interestingly enough, the tensions or misunderstandings between Alexander and his home country can be dated back to the Humboldt family, i.e. to Wilhelm from Humboldt who noted, in a letter to his wife, how his brother had "stopped to be German". Alexander von Humboldt's cosmopolitanism and the characteristic development of his scientific conceptions, building a globalized and globalizing praxis based upon a scientific network and continous comparisons in global scale, allow us to discover new dimensions in Humboldtian science and thinking as well as promising perspectives for understanding Alexander von Humboldt's role and significance for transdisciplinary science today -and a different view of Prussia and cultural identity in Europe beyond the well-known stereotypes

  5. “Wer jetzt kein Haus hat, baut sich keines mehr”. Notes on Bruce O’Neill’s "The Space of Boredom"

    Directory of Open Access Journals (Sweden)

    George Tudorie

    2017-12-01

    Full Text Available Bruce O’Neill describes homeless men and women in Bucharest who could not navigate the downward spiral which followed the meltdown of the state-run economy after 1989. Deprived of the culturally treasured anchors of work, home, and family, and unable to participate in anything recognizably meaningful, these individuals are forced into a position of malignant contemplation, even when busy surviving. It is an experience of paralyzed restlessness which resonates with the ruins they zigzag through. The Space of Boredom captures this landscape convincingly, and in elegant prose. The book moves effortlessly from the discussion of scholarly works in a number of fields, to observation of sometimes cinematic quality. It is well argued, abundantly researched, and clear about its theoretical assumptions. If some questions remain to be answered, at least to this reader, this may be an artifact of background. Assumptions, including important ones about the nature of affects, and about boredom itself, may not be shared. Some questions of this kind will be raised in the following.

  6. Application of Haar and Mexican hat wavelets to double divisor-ratio spectra for the multicomponent determination of ascorbic acid, acetylsalicylic acid and paracetamol in effervescent tablets

    OpenAIRE

    Dinç, Erdal; Baleanu, Dumitru

    2008-01-01

    Simultaneous determination of ascorbic acid (AA), acetylsalicylic acid (ASP) and paracetamol (PAR) in their synthetic mixtures and effervescent tablets were performed by Haar and Mexican continuous wavelet transforms (HAAR-CWT and MEXH-CWT, respectively) together with double divisor technique. The signal processing methods are based on the application of HAAR-CWT and MEXH-CWT to the double divisor-ratio spectra (DDRS). These spectra were obtained by dividing the absorption spectra of pure com...

  7. Pisanello’s hat. The costume and weapons depicted in Pisanello’s medal for John VIII Palaeologus. A discussion of the saber and related weapons

    Directory of Open Access Journals (Sweden)

    Alexander, David

    2004-12-01

    Full Text Available A group of six drawings by the Veronese artist Antonio Pisano depicted the Bizantine Emperor John VIII Paleologus wearing costumes and weapons according to islamic types. This paper studies these objects in relation to other contemporary islamic weapons.

    Un grupo de seis dibujos del artista veronés Antonio Pisano representa al emperador bizantino Juan VIII Paleólogo vestido y armado según modelos islámicos. Este trabajo estudia dichos objetos en relación a otras armas islámicas contemporáneas.

  8. Limitations of short range Mexican hat connection for driving target selection in a 2D neural field: activity suppression and deviation from input stimuli.

    Science.gov (United States)

    Mégardon, Geoffrey; Tandonnet, Christophe; Sumner, Petroc; Guillaume, Alain

    2015-01-01

    Dynamic Neural Field models (DNF) often use a kernel of connection with short range excitation and long range inhibition. This organization has been suggested as a model for brain structures or for artificial systems involved in winner-take-all processes such as saliency localization, perceptual decision or target/action selection. A good example of such a DNF is the superior colliculus (SC), a key structure for eye movements. Recent results suggest that the superficial layers of the SC (SCs) exhibit relatively short range inhibition with a longer time constant than excitation. The aim of the present study was to further examine the properties of a DNF with such an inhibition pattern in the context of target selection. First we tested the effects of stimulus size and shape on when and where self-maintained clusters of firing neurons appeared, using three variants of the model. In each model variant, small stimuli led to rapid formation of a spiking cluster, a range of medium sizes led to the suppression of any activity on the network and hence to no target selection, while larger sizes led to delayed selection of multiple loci. Second, we tested the model with two stimuli separated by a varying distance. Again single, none, or multiple spiking clusters could occur, depending on distance and relative stimulus strength. For short distances, activity attracted toward the strongest stimulus, reminiscent of well-known behavioral data for saccadic eye movements, while for larger distances repulsion away from the second stimulus occurred. All these properties predicted by the model suggest that the SCs, or any other neural structure thought to implement a short range MH, is an imperfect winner-take-all system. Although, those properties call for systematic testing, the discussion gathers neurophysiological and behavioral data suggesting that such properties are indeed present in target selection for saccadic eye movements.

  9. Preliminary Results on HAT-P-4, TrES-3, XO-2, and GJ 436 from the NASA EPOXI Mission

    OpenAIRE

    Ballard, Sarah; Charbonneau, David; A'Hearn, Michael F.; Deming, Drake; Holman, Matthew J.; Christiansen, Jessie L.; Weldrake, David T. F.; Barry, Richard K.; Kuchner, Marc J.; Livengood, Timothy A.; Pedelty, Jeffrey; Schultz, Alfred; Hewagama, Tilak; Sunshine, Jessica M.; Wellnitz, Dennis D.

    2008-01-01

    EPOXI (EPOCh + DIXI) is a NASA Discovery Program Mission of Opportunity using the Deep Impact flyby spacecraft. The EPOCh (Extrasolar Planet Observation and Characterization) Science Investigation will gather photometric time series of known transiting exoplanet systems from January through August 2008. Here we describe the steps in the photometric extraction of the time series and present preliminary results of the first four EPOCh targets.

  10. More than one rabbit out of the hat: Radiation, transgenic and symbiont-based approaches for sustainable management of mosquito and tsetse fly populations.

    Science.gov (United States)

    Bourtzis, Kostas; Lees, Rosemary Susan; Hendrichs, Jorge; Vreysen, Marc J B

    2016-05-01

    Mosquitoes (Diptera: Culicidae) and tsetse flies (Diptera: Glossinidae) are bloodsucking vectors of human and animal pathogens. Mosquito-borne diseases (malaria, filariasis, dengue, zika, and chikungunya) cause severe mortality and morbidity annually, and tsetse fly-borne diseases (African trypanosomes causing sleeping sickness in humans and nagana in livestock) cost Sub-Saharan Africa an estimated US$ 4750 million annually. Current reliance on insecticides for vector control is unsustainable: due to increasing insecticide resistance and growing concerns about health and environmental impacts of chemical control there is a growing need for novel, effective and safe biologically-based methods that are more sustainable. The integration of the sterile insect technique has proven successful to manage crop pests and disease vectors, particularly tsetse flies, and is likely to prove effective against mosquito vectors, particularly once sex-separation methods are improved. Transgenic and symbiont-based approaches are in development, and more advanced in (particularly Aedes) mosquitoes than in tsetse flies; however, issues around stability, sustainability and biosecurity have to be addressed, especially when considering population replacement approaches. Regulatory issues and those relating to intellectual property and economic cost of application must also be overcome. Standardised methods to assess insect quality are required to compare and predict efficacy of the different approaches. Different combinations of these three approaches could be integrated to maximise their benefits, and all have the potential to be used in tsetse and mosquito area-wide integrated pest management programmes. Copyright © 2016 The Authors. Published by Elsevier B.V. All rights reserved.

  11. Hat die Ejakulation in Medium einen Effekt auf die Schwangerschaftsrate bei der Intrazytoplasmatischen Spermieninjektion bei Patienten mit schwerer Oligoasthenoteratozoospermie? Ergebnisse einer retrospektiven Analyse

    Directory of Open Access Journals (Sweden)

    Zollner K-P

    2002-01-01

    Full Text Available Durch die Gewinnung einer Samenprobe in Medium erhöht sich der Anteil der antikörperfreien Spermatozoen in Samenproben mit antikörperbehafteten Spermien und erhöht somit die Fertilisationsrate in vitro. Das Ziel dieser Studie war es zu untersuchen, ob sich dieser Verdünnungseffekt auch günstig auf Ejakulate mit einem Oligoasthenoterato-zoospermie (OAT-Syndrom auswirkt, in denen oft eine große Anzahl an Bakterien und Zelldetritus den Spermien anhaftet. Die Zugabe von Medium vor der Verflüssigung könnte das Anhaften von Bakterien und Detritus an der Spermienoberfläche verhindern und somit zu besseren Befruchtungschancen führen. 173 Patienten, die in einem Probespermiogramm oder einem früheren IVF-Zyklus ein schweres OAT-Syndrom zeigten, wurden in diese retrospektive Studie eingeschlossen. Alle Patienten durchliefen 1997 und 1998 das ICSI-ET (Intrazytoplasmatische Spermieninjektion und Embryotransfer Programm an der Universität Würzburg. 118 Patienten gewannen ihre Samenprobe in leere, sterile Gefäße (Gruppe A und 55 Patienten ejakulierten in 20 ml Hepes gepuffertes Ham's F-10-Medium, das mit 10 % HSA (humanes Serumalbumin versetzt war (Gruppe B. Das Alter der Patientinnen und der Ehemänner, die Ejakulatparameter und die Anzahl der transferierten Embryonen war in beiden Gruppen vergleichbar. Alle Ejakulate wurden gemäß WHO-Kriterien klassifiziert. Nach Gewinnung der Samenprobe in Medium wurde das Ejakulat der Gruppe B für 30 min inkubiert, anschließend zentrifugiert und mit einer Swim-up-Technik aufbereitet. Die Ejakulate der Gruppe A wurden ebenfalls mit einer Swim-up-Technik präpariert. Bei den 173 ICSI-Zyklen konnten durchschnittlich 9,3 Eizellen gewonnen werden. Die mediane Fertilisationsrate (FR lag bei 83,3 % und unterschied sich in den Gruppen A (FR = 87,5 % und B (FR = 77,8 % nicht signifikant. Es wurden im Mittel 2,7 Embryonen transferiert. 27 von 118 Patientinnen der Gruppe A konzipierten, was zu einer klinischen Schwangerschaftsrate von 22,9 % führte. In Gruppe B konnte eine Schwangerschaftsrate von 34,5 % (19 Konzeptionen von 55 Patientinnen erzielt werden (n.s.. Die Ergebnisse zeigen, daß die Vorlage von Hepes gepuffertem Ham's F-10-Medium bei der Ejakulation bei Patienten mit Oligoasthenoteratozoospermie zu einer deutlichen, wenn auch nicht statistisch signifikanten Erhöhung der klinischen Schwangerschaftsrate führen kann. Es ist eine einfache und effiziente Methode, die bei allen Patienten mit schwerer männlicher Subfertilität Anwendung finden könnte.

  12. "Und immer hat's geklungen...". Zu Dämonie und Erlebniskrise in Brentanos "Lore Lay" und in der von Hoffmann und Kierkegaard gedeuteten Mozartschen Don-Juan-Figur

    DEFF Research Database (Denmark)

    Ekmann, Bjørn

    1995-01-01

    Clemens Brentano, fremmedgørelse, indlevelse, romantik, oplevelseskrise, Mozart, E.T.A. Hoffmann, Søren Kierkegaard, forførelsesmotiv......Clemens Brentano, fremmedgørelse, indlevelse, romantik, oplevelseskrise, Mozart, E.T.A. Hoffmann, Søren Kierkegaard, forførelsesmotiv...

  13. The Spacecraft Earth has no emergency exit. Energy and politics in the anthropocene; Das Raumschiff Erde hat keinen Notausgang. Energie und Politik im Anthropozaen

    Energy Technology Data Exchange (ETDEWEB)

    Crutzen, Paul J.; Mastrandrea, Michael D.; Schneider, Stephen H.; Davis, Mike; Sloterdijk, Peter

    2011-07-01

    The accident at the nuclear power plant in Fukushima reminds us that the handling of the people with their planet looks like a disaster movie, where rival mafia groups deliver a gun battle with large caliber weapons on board of an aircraft at an altitude of 12,000 meters. In this book contributions of climate scientists, sociologists and philosophers are compared. Michael Mastrandrea and Stephen Schneider from the Intergovernmental Panel on Climate Change (IPCC) provide a compact overview of their work and their recommendations for policy makers. Mike Davis talks about the criticism of the IPCC reports and explains why ecologic and truly democratic cities can offer a way out of the climate crisis. Peter Sloterdijk thinks about Buckminster Fuller's metaphor of the 'spaceship earth' and the end of the 'kinetic expressionism.

  14. Edebî Tür Olarak Mektup, Hatıra ve Günlüklere Yansıyanlar: Çanakkale’de Savaşan Askerlerin Mektup Hatıra ve Günlüklerinde Yer Alan Motivasyon Unsurları

    Directory of Open Access Journals (Sweden)

    Korhan Altunyay

    2014-01-01

    Full Text Available Science of literature uses different genres such as diaries, memories and letters as both literary genres and a resource of research. These genres/resources are also used for psychological researches. Letters, memories and diaries are used to analyze the writer’s subconscious and to understand from which angle the writer looks at the problems, events and life. memories and diaries. In this paper, we will use letters, memories and diaries of our soldiers in the Battle of Canakkale in order to reveal the motivation behind their behavior.

  15. Normally ordered expansion of the inverse of the coordinate operator and the momentum operator

    Energy Technology Data Exchange (ETDEWEB)

    Fan Hongyi [CCAST (World Laboratory), PO Box 8730, Beijing 100080 (China); Fu Liang [Special Class for the Gifted Young, University of Science and Technology of China, Hefei, Anhui 230026 (China)

    2003-05-09

    We derive the normally ordered expansion formulae of 1/X-hat{sup n} and 1/P-hat{sup n} by virtue of the method of integral within an ordered product of operators in the sense of the principal value integral, where X-hat, P-hat are the coordinate and momentum operator, respectively. Application of the new formula is briefly discussed.

  16. Poisson sampling - The adjusted and unadjusted estimator revisited

    Science.gov (United States)

    Michael S. Williams; Hans T. Schreuder; Gerardo H. Terrazas

    1998-01-01

    The prevailing assumption, that for Poisson sampling the adjusted estimator "Y-hat a" is always substantially more efficient than the unadjusted estimator "Y-hat u" , is shown to be incorrect. Some well known theoretical results are applicable since "Y-hat a" is a ratio-of-means estimator and "Y-hat u" a simple unbiased estimator...

  17. The effect of nine common polymorphisms in coagulation factor genes (F2, F5, F7, F12 and F13 ) on the effectiveness of statins: the GenHAT study.

    Science.gov (United States)

    Maitland-van der Zee, Anke-Hilse; Peters, Bas J M; Lynch, Amy I; Boerwinkle, Eric; Arnett, Donna K; Cheng, Suzanne; Davis, Barry R; Leiendecker-Foster, Catherine; Ford, Charles E; Eckfeldt, John H

    2009-05-01

    Pharmacogenetic research has shown that genetic variation may influence statin responsiveness. Statins exert a variety of beneficial effects beyond lipid lowering, including antithrombotic effects, which contribute to the risk reduction of cardiovascular disease. Statins have been shown to influence the expression of coagulation factors II, V, VII, XII and XIII. Data from a large randomized clinical trial of pravastatin, designed to show efficacy relative to usual care, were used to investigate whether a pharmacogenetic effect of polymorphisms in genes coding for coagulation factors II, V, VII, XII and XIII is associated with reduced fatal coronary heart disease (CHD) and nonfatal myocardial infarction, combined CHD and all-cause mortality. The Genetics of Hypertension Associated Treatment is an ancillary study of the Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial. The genotyped population in the lipid-lowering trial of Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial included 9624 participants randomly assigned to pravastatin or to usual care. The efficacy of pravastatin in reducing risk of all-cause mortality, CHD and nonfatal myocardial infarction and combined CHD, was compared among genotype strata by examining an interaction term in a proportional hazards model. None of the polymorphisms were associated with the clinical outcomes. For the F7 (-323) ins/del polymorphism there was no interaction with pravastatin for either outcome. For both the F5 Arg506Gln G>A (rs6025) polymorphism and F7 Arg353Gln G>A (rs6046) polymorphism there were no interactions with pravastatin in relation to all-cause mortality, but there were significant interactions with combined CHD [interaction hazard ratio = 1.33, 95% confidence interval (1.01-1.76) and interaction hazard ratio = 1.92, 95% confidence interval (1.00-3.65), respectively]. There were no interactions between the polymorphisms in the other coagulation genes and pravastatin in relation to any outcome. Polymorphisms in anticoagulation genes (F5 and F7) seem to modify the efficacy of pravastatin in reducing risk of cardiovascular events.

  18. The judgement of the Federal Constitutional Court on the nuclear phase-out in Germany. Every light hat its shadow; Das Urteil des BVerfG zum Atomausstieg in Deutschland. Licht und Schatten

    Energy Technology Data Exchange (ETDEWEB)

    Leidinger, Tobias [Luther Rechtsanwaltsgesellschaft, Duesseldorf (Germany)

    2017-01-15

    The 13th amendment of the German Atomic Energy Act (AtG) was a direct result of the accident in Fukushima in March 2011. As a result, not only the provisional (three-month) shutdown of the eight nuclear power plants immediately shut down after the accident finally passed the parliament, but fixed shutdown times were also decided for the remaining nine NPP's. This was both an increase of the AtG amendment of 2002 and the extension of the NPP licenses decided a few months earlier. Nuclear energy should therefore continue to serve as a ''bridge technology'' within the framework of the Federal Government's energy concept for a longer period. On 6 December 2016 the Federal Constitutional Court (BVerfG) has decided that the act on the accelerated phasing-out of nuclear energy in Germany is partly unconstitutional. The judgment is clear on a whole series of legal issues. At the same time, it raises new questions with a view to the final clarification of the compensation.

  19. Consequences of modern information display technologies in power plant control rooms. What has changed in control rooms?; Konsequenzen moderner Informationsdarbietung in der Kraftwerkswarte. Was hat sich in der Warte veraendert?

    Energy Technology Data Exchange (ETDEWEB)

    Kruip, Jochen [KSG/GfS, Essen (Germany)

    2007-03-15

    Control rooms of power plants have undergone major developments and changes, some of them considerable, over the past few years. The most visible change has been the display of information on a variety of video screens and projectors. The question examined in the article is whether the visible or invisible changes in power plant control rooms have any influence on the training of operators. In a contribution coming from the Simulator Center, this question naturally focuses on simulator training, which is to be discussed in the light of the basic objectives of this type of training. The main duty of the Essen Simulator Center is to offer first training and in-career training to the licensed operators of nuclear power plants. The experience accumulated in nearly thirty years of simulator training has been laid down in the 'Kompendium der Simulatorschulung' (Handbook of Simulator Training). Simulator training, as referred to above, is a major component of all training programs. The two main objectives of simulator training are 'reliability in operation' and 'experience' in handling the new information systems and digital I and C systems. In the future, simulators can also be used for advanced developments and for advance testing and training. (orig.)

  20. A szélsőséges időjárási jelenségek hatásai (Effects of the Extreme Weather Events

    Directory of Open Access Journals (Sweden)

    Tamás Molnár

    2015-04-01

    Full Text Available Economist Sir Nicholas Stern warned that the global warming could cause major blow to the world economy than the two world wars and the crisis in the 1930s. But where are we in this process now and what can be expected in the near future and what opportunities we are to curb the negative effects and to slow down the global warming. The world’s population is more than 7 billion people now and we will live more than 9 billion on the planet in 2050 according to the conservative estimation because daily the number of inhabitants increases by approximitaly a quarter of a million people (National Rural Strategy, 2020. The water and ecosystem resources are diminishing due to overuse and the values of ecological footprint are very high especially in the developed countries. The increase of extreme weather events and its effects associated with the global warming have also growing impact on agricultural production. This phenomenon is important because to solve the famine and the water shortage will be much bigger problem due to climate change than today. The VAHAVA reports (change-impact-response draw also attention to the issue which is also important for experts of climate change: Is it clearly climate change and if so than what the role of the human activity in it is? It seems clear that the assumption is almost poetic as the earth sends clear messages: the concentration of greenhouse gases increased suddenly in the atmosphere (carbon-dioxide, methan, nitrous oxide, etc, the average temperature continues to rise (increasing number of hot records, the sea temperature is also rising, the area of glaciers is shrinking dramatically and prolonged drought and flood waters in some places appear. The habitats of plans and animals, routes of bird migration change. The negative effects of extreme weather events thus represent a broad problem area. The effects can be devide into several groups. Some of them have impact already relatively short-term (for example affect of health of people another part of them, however, exerts a negative influence in an indirect way for a long period of time. According to our present knowledge these processes are irreversible. The 4th Water Report published by UNESCO is dealing with the one of the biggest problems which draws attention to hazards which are related water quality, groundwater, desertification, land degradation and drought (UNESCO, 2013. The report finds that the water problem occurs globally and it stresses the dangers of „isolated” thinking related to climate chnage. However, the isolated thinking appears not only within the geographical boundaries but it also can be observed in sectors together with the „isolated” solution search. Solution to the problems outlined as an innovation process have already begun in developed countries, however, the developing countries need serious help in that regard. The situation is further aggravated by perpetual competition for water between the ecosystem and socio-economic sectors.

  1. Rezension von: Gaby Temme, Christine Künzel (Hg.: Hat Strafrecht ein Geschlecht? Zur Deutung und Bedeutung der Kategorie Geschlecht in strafrechtlichen Diskursen vom 18. Jahrhundert bis heute. Bielefeld: transcript Verlag 2010.

    Directory of Open Access Journals (Sweden)

    Monika Frommel

    2010-12-01

    Full Text Available Das moderne Strafrecht sollte informelle Geschlechternormen neutralisieren. Dies gelingt auch, kann aber bei der Strafzumessung unterlaufen werden. Wie der vorliegende Band in historisch ausgerichteten Einzelstudien zeigt, war das Strafrecht nie so objektivierend, wie es die Reformen seit den 1970er Jahren anstreben. Am Beispiel der Kindsmörderin wird nachgewiesen, dass der Verstoß gegen Geschlechtertugenden auch heute noch jederzeit mit harten Strafen sanktioniert werden kann.

  2. Moorovo prokletí : na alternativní zdroje energie si počkáme, spoléhat na rychlý pokrok techniky je zrádné

    Czech Academy of Sciences Publication Activity Database

    Cílek, Václav

    2009-01-01

    Roč. 20, č. 3 (2009), s. 66-67 ISSN 0862-6545 Institutional research plan: CEZ:AV0Z30130516 Keywords : energy * energy sources * coal * petroleum * renewable resources Subject RIV: DB - Geology ; Mineralogy

  3. 1:0 for Spain. After the soccer World Championship, Spain won an important solar contest in South Africa; 1:0 fuer Spanien. Nach der Fussball-WM hat Spanien in Suedafrika nun einen wichtigen Solarwettbewerb gewonnen

    Energy Technology Data Exchange (ETDEWEB)

    Rosell, Alejandro Diego; Mattke, Sascha

    2012-03-15

    Spanish manufacturers acquired more orders for construction of industrial-scale PV systems in South Africa than their competitors from other countries. German manufacturers managed to get contracts as partners in several projects.

  4. "Zu allen diesen kirchen arbeiten hat er zugleich auch die Risse verfertigt...". Brněnský sochař Ondřej Schweigl (1735 - 1812) jako kreslíř, dekoratér a architekt

    Czech Academy of Sciences Publication Activity Database

    Valeš, Tomáš

    2013-01-01

    Roč. 62, č. 2 (2013), s. 122-137 ISSN 1211-7390 R&D Projects: GA ČR GAP409/12/0617 Institutional support: RVO:68378033 Keywords : And reas Schweigl * drawing * graphic art * sculpture * 18th century * Moravia * Brno Subject RIV: AL - Art , Architecture, Cultural Heritage

  5. The countdown for the negotiations on the exit of Great Britain from the EU and Euratom has begun; Alea iacta est. Der Countdown fuer die Verhandlungen ueber den Ausstieg Grossbritanniens aus EU und EURATOM hat begonnen

    Energy Technology Data Exchange (ETDEWEB)

    Feldmann, Ulrike

    2017-07-15

    On 29 March 2017 the official letter from the United Kingdom to the President of the EU Council was presented to inform the European Council of its intention to withdraw from the European Union (EU). The period of 2 years in Article 50 of the EU Treaty provided for the exit negotiations has thus begun to run. In the letter to the President of the Council, the UK Government expressly declares its intention to withdraw from the EU and from the Euratom Treaty (EAV). Thus the controversy about the conjunction of the withdrawal from the EU and Euratom has become obsolete.

  6. A szélsőséges időjárási jelenségek hatásai (Effects of the Extreme Weather Events)

    OpenAIRE

    Tamás Molnár; Katalin M. Barna

    2015-01-01

    Economist Sir Nicholas Stern warned that the global warming could cause major blow to the world economy than the two world wars and the crisis in the 1930s. But where are we in this process now and what can be expected in the near future and what opportunities we are to curb the negative effects and to slow down the global warming. The world’s population is more than 7 billion people now and we will live more than 9 billion on the planet in 2050 according to the conservative estimation bec...

  7. MRI in the early stage of spinal cord injury: does it have clinical relevance? An experimental study; Hat die MRT in der Fruehphase des spinalen Traumas klinische Relevanz? Eine experimentelle Studie

    Energy Technology Data Exchange (ETDEWEB)

    Hannmann, T.T. [Universitaetsklinikum Heidelberg (Germany). Abt. fuer Neuroradiologie; Freund, M. [Klinikum Aschaffenburg (Germany). Inst. fuer Radiologie und Neuroradiologie

    2007-05-15

    Purpose: An experimental technique for producing a ventral spinal trauma which imitates a slipped intervertebral disc or a fractured vertebra was evaluated using magnetic resonance imaging and histology. The results were evaluated with respect to their clinical importance. Materials and Methods: A total of 69 Wistar rats were used for this study. An inflatable angioplasty balloon device was placed dorsally or ventrally to the spinal cord in order to produce a spinal trauma. 30 rats were used to compare neurological pathologies between ventral and dorsal trauma. 30 animals underwent graded ventral spinal cord compression. Magnetic resonance imaging was performed and the results were compared to histology. Results: Using this technique, the balloon device can be placed ventrally to the spinal cord. The compression time had a direct effect on changes on magnetic resonance images and edema in histology, but a longer compression time did not produce increased bleeding. The T2-weighted MRI scans showed hyperintense changes immediately after spinal compression. Therefore, they are the appropriate way for diagnosing acute spinal injuries. Although the T1-weighted MRI scans did not change after spinal compression, they are important for diagnosing epidural hematomas. (orig.)

  8. „Ob man an die kleinen Kinder gedacht hat ...?“ Die Verhandlungen über medizinische Hilfe für deutsche Flüchtlinge in Dänemark am Ende des Zweiten Weltkriegs.

    Directory of Open Access Journals (Sweden)

    Michael Schultheiss

    2009-12-01

    Full Text Available At the beginning of May 1945 almost 250.000 refugees from the eastern parts of Germany were in Denmark, having been evacuated into the occupied kingdom. From the arrival of the first refugee in February until the German capitulation in Denmark on May 5, 1945, 6.580 refugees lost their lives. Among them were more than 4.000 children who mostly died of malnutrition and pneumonia.This article examines the reasons behind this death toll and sheds light on the negotiations pertaining to medical help for the refugees between the Danish administration and the German authorities. However, due to egoistical and political considerations both on the German and Danish sides, an agreement was never settled upon.

  9. "Kann jemand, der diese Musik gehört hat, […] noch ein schlechter Mensch sein?" – om Wieslers forandring og kunstens påståtte rolle i denne prosessen

    Directory of Open Access Journals (Sweden)

    Roswitha Skare

    2012-10-01

    Full Text Available The Life of Others (2006 has been a successful film, winning the Oscar for Best Foreign Feature in 2007. It is a film about surveillance, but also about  the lives of artists and writers in East Berlin in the middle of the 1980s, and about what role  literature and art played in the GDR and in the events of autumn 1989. The article focuses on the way the film portrays Wiesler’s transformation from hard-boiled Stasi officer into the guardian angel of his target, and shows how art – both literature and music – plays an important role in this process.

  10. Beyond Tsetse--Implications for Research and Control of Human African Trypanosomiasis Epidemics.

    Science.gov (United States)

    Welburn, Susan C; Molyneux, David H; Maudlin, Ian

    2016-03-01

    Epidemics of both forms of human African trypanosomiasis (HAT) are confined to spatially stable foci in Sub-Saharan Africa while tsetse distribution is widespread. Infection rates of Trypanosoma brucei gambiense in tsetse are extremely low and cannot account for the catastrophic epidemics of Gambian HAT (gHAT) seen over the past century. Here we examine the origins of gHAT epidemics and evidence implicating human genetics in HAT epidemiology. We discuss the role of stress causing breakdown of heritable tolerance in silent disease carriers generating gHAT outbreaks and see how peculiarities in the epidemiologies of gHAT and Rhodesian HAT (rHAT) impact on strategies for disease control. Copyright © 2015 Elsevier Ltd. All rights reserved.

  11. Histone acetyltransferases: challenges in targeting bi-substrate enzymes.

    Science.gov (United States)

    Wapenaar, Hannah; Dekker, Frank J

    2016-01-01

    Histone acetyltransferases (HATs) are epigenetic enzymes that install acetyl groups onto lysine residues of cellular proteins such as histones, transcription factors, nuclear receptors, and enzymes. HATs have been shown to play a role in diseases ranging from cancer and inflammatory diseases to neurological disorders, both through acetylations of histone proteins and non-histone proteins. Several HAT inhibitors, like bi-substrate inhibitors, natural product derivatives, small molecules, and protein-protein interaction inhibitors, have been developed. Despite their potential, a large gap remains between the biological activity of inhibitors in in vitro studies and their potential use as therapeutic agents. To bridge this gap, new potent HAT inhibitors with improved properties need to be developed. However, several challenges have been encountered in the investigation of HATs and HAT inhibitors that hinder the development of new HAT inhibitors. HATs have been shown to function in complexes consisting of many proteins. These complexes play a role in the activity and target specificity of HATs, which limits the translation of in vitro to in vivo experiments. The current HAT inhibitors suffer from undesired properties like anti-oxidant activity, reactivity, instability, low potency, or lack of selectivity between HAT subtypes and other enzymes. A characteristic feature of HATs is that they are bi-substrate enzymes that catalyze reactions between two substrates: the cofactor acetyl coenzyme A (Ac-CoA) and a lysine-containing substrate. This has important-but frequently overlooked-consequences for the determination of the inhibitory potency of small molecule HAT inhibitors and the reproducibility of enzyme inhibition experiments. We envision that a careful characterization of molecular aspects of HATs and HAT inhibitors, such as the HAT catalytic mechanism and the enzyme kinetics of small molecule HAT inhibitors, will greatly improve the development of potent and

  12. EPOXI INFLIGHT CALIBRATIONS - HRIV STELLAR PSFS V1.0

    Data.gov (United States)

    National Aeronautics and Space Administration — This data set contains a clear-filtered High Resolution Visible CCD (HRIV) point spread function (PSF) for exoplanet transit targets GJ 436, HAT-P-4, HAT-P-7,...

  13. Mobile Device Management in the DOD Enterprise Network: Factors for Risk Management, Integration, and It Acquisition

    Science.gov (United States)

    2013-03-01

    the term hacker into four classes : black hat, white hat, gray hat, and suicide. Black hats do not apply for authorization or approval to access...remote devices by individual users or a class of users that may have escalated privileges in an attempt to gain access to specific devices. An...leftmost vertical column. Attributes included antivirus and malware detection, phishing protection, and spam protection. 52 Question 19 addresses

  14. The unknown risk of vertical transmission in sleeping sickness--a literature review.

    Directory of Open Access Journals (Sweden)

    Andreas K Lindner

    Full Text Available BACKGROUND: Children with human African trypanosomiasis (HAT present with a range of generally non-specific symptoms. Late diagnosis is frequent with often tragic outcomes. Trypanosomes can infect the foetus by crossing the placenta. Unequivocal cases of congenital infection that have been reported include newborn babies of infected mothers who were diagnosed with HAT in the first 5 days of life and children of infected mothers who had never entered an endemic country themselves. METHODS: This review systematically summarizes the literature on the vertical transmission of HAT, to our knowledge for the first time. To approach the broader aspects of the subject, articles considering the epidemiology of childhood HAT and HAT in pregnancy were also included. The HAT guidelines and technical reports of the World Health Organisation, Médecins Sans Frontières, Institut de Recherche pour le Développement, and of one endemic country were reviewed. RESULTS: Publications describing congenital HAT are very limited and consist only of single case reports and small case series. Generally it is assumed to be a rare event, but it has never been systematically investigated. In two publications, it is hypothesized that congenital HAT occurs more often than suspected. Not all guidelines and not all HAT literature mention this transmission route. CONCLUSIONS: The risk of vertical transmission is unknown. Awareness of congenital HAT is insufficient, and as a result opportunities for an early diagnosis in newborns may be missed. All HAT guidelines and local HAT protocols should stress that in endemic areas pregnant women should be systematically checked for HAT and that newborns of HAT infected mothers should be assessed for the disease as soon as possible. Studies on the impact of HAT on fertility and pregnancy and studies on congenital HAT are long overdue.

  15. Untitled

    African Journals Online (AJOL)

    haemoflagelates of the genus Trypanosoma. It has been reported that there remains 200 active foci for HAT between latitudes lSON and 1508. Sixty million people living in ... Definition of HAT case: A person was considered to have HAT if he/she was positive for trypanosomes in blood or cerebrospinal. fluid by haematocrit ...

  16. Inhibition of the PCAF histone acetyl transferase and cell proliferation by isothiazolones

    NARCIS (Netherlands)

    Dekker, Frank J.; Ghizzoni, Massimo; van der Meer, Nanette; Wisastra, Rosalina; Haisma, Hidde J.

    2009-01-01

    Small molecule HAT inhibitors are useful tools to unravel the role of histone acetyl transferases (HATs) in the cell and have relevance for oncology. We present a systematic investigation of the inhibition of the HAT p300/CBP Associated Factor (PCAF) by isothiazolones with different substitutions.

  17. The Evolution of a Symbol: Mokorotlo and National Identity in Lesotho

    African Journals Online (AJOL)

    The process by which these hats became associated with Moshoeshoe is reflective of the construction of national identity in Lesotho. The hat had become a powerful symbol of the nation, as one Mosotho stated, "everytime we see that hat on the flag or on the automotive licence plates we are reminded of Moshoeshoe."

  18. A Phase III Diagnostic Accuracy Study of a Rapid Diagnostic Test for Diagnosis of Second-Stage Human African Trypanosomiasis in the Democratic Republic of the Congo

    Directory of Open Access Journals (Sweden)

    Marleen Boelaert

    2018-01-01

    Conclusion: The high sensitivity of the HAT Sero K-SeT is in line with previously published estimates, though the sample of HAT cases in this study was small. The specificity estimate was very high and precise. This test, when negative, allows the clinician to rule out HAT in a clinical suspect in a hospital setting in this endemic region.

  19. Matrix transformation of Fibonacci band matrix on generalized $bv$-space and its dual spaces

    Directory of Open Access Journals (Sweden)

    Anupam Das

    2018-07-01

    Full Text Available In this paper we introduce a new sequence space $bv(\\hat{F}$ by using the Fibonacci band matrix $\\hat{F}.$ We also establish a few inclusion relations concerning this space and determine its $\\alpha-,\\beta-,\\gamma-$duals. Finally we characterize some matrix classes on the space $bv(\\hat{F}.$

  20. 16 CFR 1610.36 - Application of Act to particular types of products.

    Science.gov (United States)

    2010-01-01

    ... products. 1610.36 Section 1610.36 Commercial Practices CONSUMER PRODUCT SAFETY COMMISSION FLAMMABLE FABRICS.... (b) Hats, gloves, and footwear. Fabrics intended or sold for use in those hats, gloves, and footwear... intended end use of such fabrics, and any person manufacturing hats, gloves, or footwear containing such...

  1. Human African trypanosomiasis in non-endemic countries.

    Science.gov (United States)

    Sudarshi, Darshan; Brown, Mike

    2015-02-01

    Human African trypanosomiasis (HAT) or sleeping sickness is a parasitic disease, acquired by the bite of an infected tsetse fly. In non-endemic countries HAT is rare, and therefore the diagnosis may be delayed leading to potentially fatal consequences. In this article the clinical presentation, diagnosis and treatment of the two forms of HAT are outlined. Rhodesiense HAT is an acute illness that presents in tourists who have recently visited game parks in Eastern or Southern Africa, whereas Gambiense HAT has a more chronic clinical course, in individuals from West or Central Africa. © 2015 Royal College of Physicians.

  2. Matrix Representation in Quantum Mechanics with Non-Negative QDF in the Case of a Hydrogen-Like Atom

    CERN Document Server

    Zhidkov, E P; Lovetsky, K P; Tretiakov, N P

    2002-01-01

    The correspondence rules A(q,p)\\mapsto\\hat{A} of the orthodoxal quantum mechanics do not allow one to introduce into the theory the non-negative quantum distribution function F(q,p). The correspondence rules A(q,p)\\mapsto\\hat{O}(A) of Kuryshkin's quantum mechanics (QMK) do allow one to do it. Besides, the operators \\hat{O}(A) turn out to be \\hat{A} bounded and \\hat{A} small at infinity for all systems of auxiliary functions {\\varphi_k}. This allows one to realise canonical matrix representation of QMK to investigate its dependence on the systems of functions {\\varphi_k}.

  3. The ladder operator normal ordering problem for quantum confined systems and the generalization of the Stirling and Bell numbers

    International Nuclear Information System (INIS)

    Aleixo, A N F; Balantekin, A B

    2010-01-01

    We solve the normal ordering problem for the ladder operators B-hat + and B-hat - for strings in the form (B-hat + r B-hat - s ) n for supersymmetric and shape-invariant potential systems, with r, s and n positive integers. We provide exact and explicit expressions for their normal form N{(B-hat + r B-hat - s ) n }, where N{...} all B-hat - are at the right side, and find that the solution involves an expansion coefficients sequence which, for r, s > 1, corresponds to the generalization, for any shape-invariant potential system, of the classical Stirling and Bell numbers. We show that these numbers are obtained for families of polynomials generated with parameters related to the forms of the supersymmetric partner potentials. We apply the general formalism to Poeschl-Teller, Morse, Scarf and self-similar potential systems.

  4. Knowledge and prevalence of Human African Trypanosomiasis among residents of Kachia grazing reserve, Kachia local government area, Kaduna state, Nigeria, 2012.

    Science.gov (United States)

    Uba, Belinda Vernyuy; Aliyu, Ahmad; Abubakar, Aisha; Uba, Sabo Ado; Gidado, Saheed; Edukugho, Aboyowa; Anagbogu, Ifeoma; Kalejaiye, John; Nguku, Patrick

    2016-01-01

    Human African Trypanosomiasis (HAT) is a vector borne parasitic disease transmitted to humans by infected tse-tse flies cause morbidity including delayed child mental development. Reports of nuisance and bites from tse-tse flies by residents of Kachia grazing led to the study to determine the knowledge, practices and prevalence of HAT among residents of the grazing reserve. We conducted active case search in a cross-sectional study using multi-stage sampling with probability proportionate to size. We administered structured questionnaire on Knowledge, practices relating to HAT prevention and screened for HAT using card agglutination test for Trypanosomiasis (CATT). Knowledge of HAT was scored 0-5 and categorized good (3-5) and poor (0-2) based on score, predisposition to risk of HAT as exposure to ≥two risk factors and, a case of HAT as any respondent that tested positive on CATT. We analysed data using Epi-info and MS-excel. Of the 300 respondents, mean age 39(±17years) interviewed, 56.3% were males, 12.0% had good knowledge of HAT and 76.3% were exposed to HAT risk factors. Prevention practices included clearing of overgrown bushes around houses (99%), use of insecticidal treated nets (75.7%) and protective clothing (41.0%). Males {Odds Ratio [OR] 5.0; 95% Confidence Interval (CI) 1.8 - 13.6}, age above 40 years {OR 5.0; 95% CI 1.1 - 24.4} and family history of HAT {OR 8.7; 95% CI 2.4 - 32.1} were significantly associated with HAT knowledge. None tested positive on CATT. Despite poor knowledge of HAT, residents practiced HAT preventive measures and zero HAT prevalence was recorded.

  5. Fundamental investigations for a OWC-tidal power plant with a conventional hydraulic turbine; Basisuntersuchungen fuer ein OWC-Wellenenergiekraftwerk mit konventioneller Hydroturbine. Abschlussbericht

    Energy Technology Data Exchange (ETDEWEB)

    Graw, K.U.; Lengricht, J.; Schimmels, S.

    2001-07-01

    At the present the OWC-tidal power plant is the most forward-looking way of converting tidal energy into usable electric power. Current research works focus on the dimensions of the structures in terms of occurring loads, the minimisation of hydraulic losses and the development of new turbine-generator types. The development of all air-turbine systems, which have been investigated so far, is considered as problematic and the commercialisation is likely to be a hindrance. Based on international research results an inventory tata of available hydraulic turbines is supposed to be gathered and fundamental investigations are supposed to check, if the application of conventional hydraulic turbines are an energetic progress in the OWC-tidal power plant. In order to considerably increase the efficiency compared to current developments, small-scale investigations at a physical model are supposed to show if and how a hydraulic turbine can be realised in a OWC-tidal power plant and how a concept of flow rectification as well as a flow-optimised form of inflow and outflow chambers can be achieved. (orig.) [German] Das OWC-Wellenenergiekraftwerk ist der zur Zeit zukunftstraechtigste Typ zur Umwandlung von Wellenenergie in nutzbaren Strom. Die laufenden Forschungsarbeiten beschaeftigen sich insbesondere mit der Dimensionierung der Strukturen hinsichtlich auftretender Belastungen, der Minimierung der hydraulischen Verluste und der Entwicklung von neuartigen Turbinen-Generatoren-Typen. Die Entwicklung aller bisher untersuchten Luftturbinensysteme wird jedoch als problematisch und die Kommerzialisierung hindernd angesehen. Aufbauend auf den internationalen Forschungsergebnissen sollen eine Bestandaufnahme der verfuegbaren Hydroturbinen durchgefuehrt und mit Baisuntersuchungen geprueft werden, ob ein Einsatz konventionaller Hydroturbinen im OWC-Wellenenergiekraftwerk eine energetische Weiterentwicklung darstellen kann. Um den Wirkungsgrad gegenueber derzeitigen Entwicklungen

  6. A Human-Autonomy Teaming Approach for a Flight-Following Task

    Science.gov (United States)

    Brandt, Summer L.; Russell, Ricky; Lachter, Joel; Shively, Robert

    2017-01-01

    Managing aircraft is becoming more complex with increasingly sophisticated automation responsible for more flight tasks. With this increased complexity, it is becoming more difficult for operators to understand what the automation is doing and why. Human involvement with increasingly autonomous systems must adjust to allow for a more dynamic relationship involving cooperation and teamwork. As part of an ongoing project to develop a framework for human-autonomy teaming (HAT) in aviation, a part-task study was conducted to demonstrate, evaluate and refine proposed critical aspects of HAT. These features were built into an automated recommender system on a ground station available from previous studies. Participants performed a flight-following task once with the original ground station (i.e., No HAT condition) and once with the HAT features enabled (i.e., HAT condition). Behavioral and subjective measures were collected; subjective measures are presented here. Overall, participants preferred the ground station with HAT features enabled compared to the station without the HAT features. Participants reported that the HAT displays and automation were preferred for keeping up with operationally important issues. Additionally, participants reported that the HAT displays and automation provided enough situation awareness to complete the task and reduced workload relative to the No HAT baseline.

  7. The relationship between the biomass of Cameroonian tropical forests and radiation reflected in middle infrared wavelengths (3.0-5.0 micro m)

    International Nuclear Information System (INIS)

    Boyd, D.S.; Foody, G.M.; Curran, P.J.

    1999-01-01

    The continued northwards spread of Rhodesian sleeping sickness or Human African Trypanosomiasis (HAT) within Uganda is raising concerns of overlap with the Gambian form of the disease. Disease convergence would result in compromised diagnosis and treatment for HAT. Spatial determinants for HAT are poorly understood across small areas. This study examines the relationships between Rhodesian HAT and several environmental, climatic and social factors in two newly affected districts, Kaberamaido and Dokolo. A one-step logistic regression analysis of HAT prevalence and a two-step logistic regression method permitted separate analysis of both HAT occurrence and HAT prevalence. Both the occurrence and prevalence of HAT were negatively correlated with distance to the closest livestock market in all models. The significance of distance to the closest livestock market strongly indicates that HAT may have been introduced to this previously unaffected area via the movement of infected, untreated livestock from endemic areas. This illustrates the importance of the animal reservoir in disease transmission, and highlights the need for trypanosomiasis control in livestock and the stringent implementation of regulations requiring the treatment of cattle prior to sale at livestock markets to prevent any further spread of Rhodesian HAT within Uganda. (author)

  8. Spatial predictions of Rhodesian Human African Trypanosomiasis (sleeping sickness prevalence in Kaberamaido and Dokolo, two newly affected districts of Uganda.

    Directory of Open Access Journals (Sweden)

    Nicola A Batchelor

    2009-12-01

    Full Text Available The continued northwards spread of Rhodesian sleeping sickness or Human African Trypanosomiasis (HAT within Uganda is raising concerns of overlap with the Gambian form of the disease. Disease convergence would result in compromised diagnosis and treatment for HAT. Spatial determinants for HAT are poorly understood across small areas. This study examines the relationships between Rhodesian HAT and several environmental, climatic and social factors in two newly affected districts, Kaberamaido and Dokolo. A one-step logistic regression analysis of HAT prevalence and a two-step logistic regression method permitted separate analysis of both HAT occurrence and HAT prevalence. Both the occurrence and prevalence of HAT were negatively correlated with distance to the closest livestock market in all models. The significance of distance to the closest livestock market strongly indicates that HAT may have been introduced to this previously unaffected area via the movement of infected, untreated livestock from endemic areas. This illustrates the importance of the animal reservoir in disease transmission, and highlights the need for trypanosomiasis control in livestock and the stringent implementation of regulations requiring the treatment of cattle prior to sale at livestock markets to prevent any further spread of Rhodesian HAT within Uganda.

  9. Impact of Aging and Cognition on Hearing Assistive Technology Use.

    Science.gov (United States)

    Jorgensen, Lindsey E; Messersmith, Jessica J

    2015-08-01

    Many factors go into appropriate recommendation and use of hearing assistive technology (HAT). The aging auditory system presents with its own complications and intricacies; there are many types of age-related hearing loss, and it is possible that the underlying cause of hearing loss can significantly impact the recommendations and performance with HATs. The audiologist should take into consideration peripheral and central auditory function when selecting HATs for the aging adult population as well as when selecting appropriate types of technology including personal sound amplification products, hearing aids, cochlear implants, and other assistive technology. The cognitive ability of the patient plays a central role in the recommendations of HAT. It is possible that the use of HATs could mitigate some of the effects of cognitive decline and thus should be considered as early as possible. Assessment of ability and appropriate recommendations are crucial to consistent use of HAT devices.

  10. SOME EMBEZZLEMENT (CORRUPTION CLAIMS TOOK PLACE IN ISTANBUL PRESS TOWARDS THE COMMITTEE OF UNION AND PROGRESS / İTTİHAT VE TERAKKİ’YE YÖNELİK İSTANBUL BASININDA YER ALAN BAZI YOLSUZLUK İDDİALARI

    Directory of Open Access Journals (Sweden)

    Dr. Mehmet AYDIN

    2008-12-01

    Full Text Available The aim of this study is to handle theembezzlement (corruption claims stemmed from scial,political and economical policy of the Committee of Unionand Progress and also took place in Đstanbul Press drungthe World War, I. This study also deals with the reasonsand results of these embezzlement claims took place inthe press and states that the mentioned claims had inrelation whith the national economy policy and thestatist economy policy of the Committee of Union andProgress.

  11. A PROSAIC BOOK OF ADVICES WRITTEN IN 16. CENTURY: ABDULKERIM BIN MEHMED’S NESAYIHU’L-EBRAR 16. ASIRDA YAZILMIŞ MENSUR BİR NASİHAT-NÂME: ABDÜLKERİM BİN MEHMED’İN NESÂYİHÜ’L-EBRÂR’I

    Directory of Open Access Journals (Sweden)

    Ramazan EKİNCİ

    2012-06-01

    Full Text Available Works that direct people to the good, the beauty, the truth and raise moral and benefical individuals for society are called book of advice. These moral and didactic works have poetical and prosaic samples. One of the prosaic book of advices is Nesayihu’l-Ebrar, which was written by Abdulkerim bin Mehmed, grandson of Şeyhulislam Ebussuud Efendi who was famous for his shaykh al-islam position and his many books written in law, hermeneutics, doctrines, language and literature.In this article, Nesayihu’l-Ebrar, which has many transcripts in national libraries and libraries in abroad, will be introduced. The life of Abdulkerim bin Mehmed will be laid emphasis on and four transcripts of the work will be criticized comperatively. İnsanları iyiye, doğruya ve güzele yöneltmek; topluma faydalı, ahlâklı bireyler yetişmesini sağlamak maksadıyla kaleme alınan eserlere nasihat-nâme, pend-nâme, öğüt-nâme vb. adlar verilir. Ahlâkî-didaktik nitelikteki bu eserlerin manzum ve mensur örnekleri mevcuttur. Mensur nasihat-nâmelerden biri de tefsir, hukuk, akaid, dil ve edebiyat alanında birçok eser yazan, fetvalarıyla ve uzun süre şeyhülislâmlık makamında bulunmasıyla meşhur olan Şeyhülislâm Ebüssuûd Efendi’nin torunu Abdülkerim bin Mehmed tarafından kaleme alınan Nesâyihü’l-Ebrâr adlı eserdir. Bu makalede, yurtiçi ve yurtdışındaki kütüphanelerde ondan fazla nüshası bulunan Nesâyihü’l-Ebrâr tanıtılacak; ulaşabildiğimiz kaynaklar doğrultusunda eserin müellifi Abdülkerim bin Mehmed’in hayatı üzerinde durulacak ve söz konusu nasihat-nâmenin dört nüshası esas alınarak tenkitli metni verilecektir.

  12. Birleştirme-II Tekniğinin Fransızca Okuma Dersinde Öğrenilen Sözcükleri Hatırda Tutmaya Etkisi (Effect of Jigsaw-II on the Retention of New Words Learned in the Course of Reading in French

    Directory of Open Access Journals (Sweden)

    Zühre YILMAZ GÜNGÖR

    2011-10-01

    Full Text Available The purpose of this research is to find the effect of the Jigsaw-II technique regarding the retention of new words learned in the French reading course conducted with freshman of the French Foreign Language Department. In this research, comparative unsynchronized group post-test model was used. The participants of this research are 1st year students studying in the French Foreign Language Department of the Anadolu University (Eskişehir during the spring semester of the academic year 2009-2010. There were 16 participants in the experimental group, 14 participants in the control group. The data were analyzed by analysis of frequency and percentage. As a result, in contrast to the control group using traditional teaching methods, students of the experimental group were greatly remembered new words learned in French reading course.

  13. William Wordsworth's 'Double Awareness' of Memory in Virginia Woolf's Mrs Dalloway = William Wordsworth'un 'Hatıranın Çift Yönlü Algılaması' Kavramının Virgina Woolf'un Mrs Dalloway Adlı Romanındaki Kullanımı

    Directory of Open Access Journals (Sweden)

    Ali GÜNEŞ

    2003-06-01

    Full Text Available This article deals with Romanticism in modernist British writer Virginia Woolf's novel, Mrs Dalloway. Although her works are experimental and new, they are part of a wider and developing perspective in the historical process of literary tradition, so that they cannot be viewed as completely breaking away from literary tradition, but rather as a reworking and redevelopment in its evolution. In her reworking of the traditional novel, this paper may suggest that Woolf made it "new" by returning to the Romantics, particularly to Wordsworth. By this claim, this paper does not mean that Woolf copied Wordsworth exactly, but was profoundly and pervasively influenced by his aesthetic views, especially in relation to her understanding of life as "consciousness". By returning to the Romantics, Woolf develops her sense of "reality" as both fragmented and whole, and of the "self" as fragmented but desiring and imagining unity. Hence she not only strove to construct a poetical or lyrical novel to express that contradictory view but also used her fiction to explore the mystery of the subjective consciousness as the dominant modernist view. In order to express her perception of modernist identity, Woolf used memory as a device in Mrs Dalloway and thus developed a new way of narration as well as a new view of human identity. By means of this new method, she left the objective narration of the traditional novel, and thus meaning or the view of identity in Woolf's late fiction is not static but undecided, unfinished and mysterious.

  14. A globalizáció és a kohéziós politika hatása Magyarországon a 2014-2020-as időszakban (Globalisation and the Effect of the Cohesion Policy in Hungary in 2014-2020

    Directory of Open Access Journals (Sweden)

    Csaba Sarido

    2016-08-01

    Full Text Available Globalisation entails social, political, technological, environmental and cultural cross-border exchange and links, which connect individuals, communities and governments, all over the world. Major environmental problems, such as air pollution, deforestation, the hole in the ozone layer and global warming, have to be solved, because they affect everyone living on earth. Saving ecosystems through the conservation of non-renewable energy sources and the preservation of natural habitats is of primary importance, as well. According to the EU budget for 2014-2020 the cohesion policy invests 325 billion euros in member states in order to be able to accomplish the aims related to growth and the creation of workplaces and deal with the challenges of climate change, energy dependency and social exclusion. The smart, sustainable and inclusive growth should be highlighted from the strategic objectives of cohesion policy and the 11 thematic objectives, the accomplishment of which is compulsory for all the member states. The template requirement of the implementation of EU goals makes it difficult to enforce national aims and their representation in development plans. Another problem is that among the goals there are no specifically regional ones. The most important regulatory changes in the new budget cycle refer to the reduction of utilizable funds, strengthening resource and thematic concentration, stricter measurement of results, and making it more difficult to access funds. The system of aims of the Széchenyi 2020 development plan is adjusted to the regulations following the value aims of Europe 2020 strategy and formulates sustainable, high added value production, expansion of employment and national aims promoting economic growth. The 8 cohesion programs including the national contribution envisage the use of 25297 billion euros, the 60 percent of which serves the goals of economic development. Priority is given to regional and municipal development, environmental and energy efficiency, traffic and human resource development. In the paper we deal with the changes and strategy of cohesion policy and the Széchenyi 2020 development plan. We evaluate the development possibilities regarding self-governments, the decentralization of funds and new regional integration tools. Hungary meets the EU requirements in the 7 year period starting in 2014, and takes one of the most advantageous net positions in the ranking of EU 28.

  15. Foglalkoztatási lehetőségek a határon túl – avagy a migrációs folyamatok vizsgálata a kelet-közép-európai térben (Employment Opportunities beyond the Border – Analysis of Migration Trends in Central-Eastern-European Space

    Directory of Open Access Journals (Sweden)

    Katalin Lipták

    2015-12-01

    Full Text Available In this study I examine the main factors of migration, in particular to globalization, as well as the unemployment. This factor affects the migration processes. The main effect of globalization on labor market is manifested most in demand for labor flexibility and growth rather than an overall reduction in demand site. The factors of production in the global economy will be higher mobility than before, so the workforce as an economic factor in the globalization movement across national boundaries thereof. The processes associated with adverse global decline in the working age population (whose evolution I demonstrate this with calculating the Hoover index. A variety of factors can not easily be separated from each other of migration trends with respect. An increasing number of skilled workers get work in Eastern Europe.

  16. Chernobyl - 30 years thereafter. Has radiation protection in Switzerland been improved for the handling of emergency situations and the long-term consequences?; Tschernobyl. 30 Jahre danach. Hat sich der Strahlenschutz in der Schweiz zur Bewaeltigung einer Notfallsituation und deren langfristiger Konsequenzen verbessert?

    Energy Technology Data Exchange (ETDEWEB)

    Murith, Christophe [Bundesamt fuer Gesundheit (BAG), Bern (Switzerland). Abt. Strahlenschutz

    2016-05-01

    30 years ago the Chernobyl reactor accident has surprised the whole world. It was shown that severe nuclear accidents contaminating large areas for a long time are possible. At this time each state was overstrained and unable to cope with the situation. Switzerland was oscillating between the French disregard and the German psychosis resulting in chaotic communication increased by incoherency and missing consultation with the neighboring countries.

  17. Demonstration of Human-Autonomy Teaming Principles

    Science.gov (United States)

    Shively, Robert Jay

    2016-01-01

    Known problems with automation include lack of mode awareness, automation brittleness, and risk of miscalibrated trust. Human-Autonomy Teaming (HAT) is essential for improving these problems. We have identified some critical components of HAT and ran a part-task study to introduce these components to a ground station that supports flight following of multiple aircraft. Our goal was to demonstrate, evaluate, and refine HAT principles. This presentation provides a brief summary of the study and initial findings.

  18. Some properties of Generalized Fibonacci difference bounded and $p$-absolutely convergent sequences

    Directory of Open Access Journals (Sweden)

    Bipan Hazarika

    2018-01-01

    Full Text Available The main objective of this paper is to introduced a new sequence space $l_{p}(\\hat{F}(r,s,$ $ 1\\leq p \\leq \\infty$ by using the band matrix $\\hat{F}(r,s.$ We also establish a few inclusion relations concerning this space and determine its $\\alpha-,\\beta-,\\gamma-$duals. We also characterize some matrix classes on the space $l_{p}(\\hat{F}(r,s$ and examine some geometric properties of this space.

  19. Accuracy of individual rapid tests for serodiagnosis of gambiense sleeping sickness in West Africa.

    Directory of Open Access Journals (Sweden)

    Vincent Jamonneau

    2015-02-01

    Full Text Available Individual rapid tests for serodiagnosis (RDT of human African trypanosomiasis (HAT are particularly suited for passive screening and surveillance. However, so far, no large scale evaluation of RDTs has been performed for diagnosis of Trypanosoma brucei gambiense HAT in West Africa. The objective of this study was to assess the diagnostic accuracy of 2 commercial HAT-RDTs on stored plasma samples from West Africa.SD Bioline HAT and HAT Sero-K-Set were performed on 722 plasma samples originating from Guinea and Côte d'Ivoire, including 231 parasitologically confirmed HAT patients, 257 healthy controls, and 234 unconfirmed individuals whose blood tested antibody positive in the card agglutination test but negative by parasitological tests. Immune trypanolysis was performed as a reference test for trypanosome specific antibody presence. Sensitivities in HAT patients were respectively 99.6% for SD Bioline HAT, and 99.1% for HAT Sero-K-Set, specificities in healthy controls were respectively 87.9% and 88.3%. Considering combined positivity in both RDTs, increased the specificity significantly (p ≤ 0.0003 to 93.4%, while 98.7% sensitivity was maintained. Specificities in controls were 98.7-99.6% for the combination of one or two RDTs with trypanolysis, maintaining a sensitivity of at least 98.1%.The observed specificity of the single RDTs was relatively low. Serial application of SD Bioline HAT and HAT Sero-K-Set might offer superior specificity compared to a single RDT, maintaining high sensitivity. The combination of one or two RDTs with trypanolysis seems promising for HAT surveillance.

  20. Human African trypanosomiasis in a Belgian traveller returning from the Masai Mara area, Kenya, February 2012.

    Science.gov (United States)

    Clerinx, J; Vlieghe, E; Asselman, V; Van de Casteele, S; Maes, M B; Lejon, V

    2012-03-08

    A Belgian traveller was diagnosed with human African trypanosomiasis (HAT) due to Trypanosoma brucei rhodesiense nine days after visiting the Masai Mara area in Kenya. He presented with an inoculation chancre and was treated with suramin within four days of fever onset. Two weeks earlier, HAT was also reported in a German traveller who had visited the Masai Mara area. Because no cases have occurred in the area for over 12 years, this may indicate a focal cluster of HAT.

  1. Las actividades rurales no-agrarias en familias campesinas de la sierra norte del Perú

    OpenAIRE

    Jackeline Velazco

    1998-01-01

    The aim of the document is to analyse the options of expansion that hat manufacture within peasant families of Bambamarca have. This is a part of one objective: the promotion of non-farming rural activities as a strategy to increase poor family’s income. A theoretical model, which allows identifying the growing possibilities of traditional transforming activities (Z goods), is developed. For the manufacture of hats case the problem was: how to transform hats from inferior goods to normal good...

  2. Searching for cosmological preferred axis using cosmographic approach

    Science.gov (United States)

    Salehi, Amin; Setare, Mohammad Reza

    2017-12-01

    Recent released Planck data and other astronomical observations show that the universe may be anisotropic on large scales. This hints a cosmological privileged axis in our anisotropic expanding universe. This paper proceeds a modified redshift in anisotropic cosmological model as 1+\\tilde{z}(t,\\hat{{p})=a(t_{0)}/a(t)(1-A(\\hat{n}.\\hat{p})) (where A is the magnitude of anisotropy, \\hat{n} is the direction of privileged axis, and \\hat{p} is the direction of each SNe Ia sample to galactic coordinates) along with anisotropic parameter δ =A(\\hat{n}.\\hat{p})/1+A(\\hat{n.\\hat{p})}. The luminosity distance is expanded with model-independent cosmographic parameters as a function of modified redshift \\tilde{z}. As the transformation matrix M(n× n) is obtained to convert the Taylor series coefficients of isotropic luminosity distance to corresponding anisotropic parameters. These results culminate the magnitude of anisotropy about \\mid A\\mid ˜eq 10^{-3} and the direction of preferred axis as (l,b)=( 297^{-34}_{+34},3^{-28}_{+28}) , which are consistent with other studies in 1-σ confidence level.

  3. 'n Evaluasie van Pharos Aanleerderwoordeboek vir skole/ Learner's ...

    African Journals Online (AJOL)

    'n Evaluasie van Pharos Aanleerderwoordeboek vir skole/ Learner's Dictionary for Schools en Longman-HAT Afrikaans Dictionary and Grammar for English Speakers in 'n Afrikaanse taalverwerwingskursus op universiteitsvlak.

  4. Mulle meeldis! / Toomas Velmet

    Index Scriptorium Estoniae

    Velmet, Toomas, 1942-

    2009-01-01

    14. augustil Birgitta festivali raames toimunud Aram Hatšaturjani balleti "Spartacus" (lavastajad-koreograafid Natalja Kassatkina ja Vladimir Vassiljov) etendamisest Moskva Riikliku Akadeemilise Balletiteatri trupi esituses

  5. Monitoring the elimination of human African trypanosomiasis: Update to 2014.

    Directory of Open Access Journals (Sweden)

    José R Franco

    2017-05-01

    Full Text Available The World Health Organization (WHO has targeted the elimination of Human African trypanosomiasis (HAT 'as a public health problem' by 2020. The selected indicators of elimination should be monitored every two years, and we provide here a comprehensive update to 2014. The monitoring system is underpinned by the Atlas of HAT.With 3,797 reported cases in 2014, the corresponding milestone (5,000 cases was surpassed, and the 2020 global target of 'fewer than 2,000 reported cases per year' seems within reach. The areas where HAT is still a public health problem (i.e. > 1 HAT reported case per 10,000 people per year have halved in less than a decade, and in 2014 they corresponded to 350 thousand km2. The number and potential coverage of fixed health facilities offering diagnosis and treatment for HAT has expanded, and approximately 1,000 are now operating in 23 endemic countries. The observed trends are supported by sustained surveillance and improved reporting.HAT elimination appears to be on track. For gambiense HAT, still accounting for the vast majority of reported cases, progress continues unabated in a context of sustained intensity of screening activities. For rhodesiense HAT, a slow-down was observed in the last few years. Looking beyond the 2020 target, innovative tools and approaches will be increasingly needed. Coordination, through the WHO network for HAT elimination, will remain crucial to overcome the foreseeable and unforeseeable challenges that an elimination process will inevitably pose.

  6. Monitoring the elimination of human African trypanosomiasis: Update to 2014.

    Science.gov (United States)

    Franco, José R; Cecchi, Giuliano; Priotto, Gerardo; Paone, Massimo; Diarra, Abdoulaye; Grout, Lise; Mattioli, Raffaele C; Argaw, Daniel

    2017-05-01

    The World Health Organization (WHO) has targeted the elimination of Human African trypanosomiasis (HAT) 'as a public health problem' by 2020. The selected indicators of elimination should be monitored every two years, and we provide here a comprehensive update to 2014. The monitoring system is underpinned by the Atlas of HAT. With 3,797 reported cases in 2014, the corresponding milestone (5,000 cases) was surpassed, and the 2020 global target of 'fewer than 2,000 reported cases per year' seems within reach. The areas where HAT is still a public health problem (i.e. > 1 HAT reported case per 10,000 people per year) have halved in less than a decade, and in 2014 they corresponded to 350 thousand km2. The number and potential coverage of fixed health facilities offering diagnosis and treatment for HAT has expanded, and approximately 1,000 are now operating in 23 endemic countries. The observed trends are supported by sustained surveillance and improved reporting. HAT elimination appears to be on track. For gambiense HAT, still accounting for the vast majority of reported cases, progress continues unabated in a context of sustained intensity of screening activities. For rhodesiense HAT, a slow-down was observed in the last few years. Looking beyond the 2020 target, innovative tools and approaches will be increasingly needed. Coordination, through the WHO network for HAT elimination, will remain crucial to overcome the foreseeable and unforeseeable challenges that an elimination process will inevitably pose.

  7. Human African trypanosomiasis control: Achievements and challenges.

    Science.gov (United States)

    Aksoy, Serap; Buscher, Phillipe; Lehane, Mike; Solano, Philippe; Van Den Abbeele, Jan

    2017-04-01

    Sleeping sickness, also known as human African trypanosomiasis (HAT), is a neglected disease that impacts 70 million people living in 1.55 million km2 in sub-Saharan Africa. Since the beginning of the 20th century, there have been multiple HAT epidemics in sub-Saharan Africa, with the most recent epidemic in the 1990s resulting in about half a million HAT cases reported between 1990 and 2015. Here we review the status of HAT disease at the current time and the toolbox available for its control. We also highlight future opportunities under development towards novel or improved interventions.

  8. Factors influencing passive surveillance for T. b. rhodesiense human african trypanosomiasis in Uganda.

    Science.gov (United States)

    Acup, Christine; Bardosh, Kevin Louis; Picozzi, Kim; Waiswa, Charles; Welburn, Susan Christina

    2017-01-01

    Sleeping sickness or Human African Trypanosomiasis (HAT) is a neglected tropical disease of public health importance across much of Sub-Saharan Africa. In Uganda, chronic T. b. gambiense HAT (gHAT) and acute T. b. rhodesiense HAT (rHAT) occur in two large but discrete geographical foci. Both forms are difficult to diagnose, expensive to treat and ultimately fatal in the absence of treatment. The area affected by zoonotic rHAT has been steadily expanding, placing a high burden on local health systems. HAT is a disease of neglected populations and is notorious for being under-reported. Here we examine the factors that influence passive rHAT surveillance within the district health system in four Ugandan districts into which the disease had recently been introduced, focusing on staff knowledge, infrastructure and data management. A mixed methods study was undertaken between 2011 and 2013 in Dokolo, Kaberamaido, Soroti and Serere districts to explore health facility capacity and clinical service provision, diagnostic capacity, HAT knowledge and case reporting. Structured interviews were undertaken with 86 medical personnel, including clinicians, nurses, midwives and technicians across 65 HC-II and HC-III medical facilities, where the health infrastructure was also directly observed. Eleven semi-structured interviews were undertaken with medical staff in each of the three designated HAT treatment facilities (Dokolo, Lwala and Serere HC-IV) in the area. HAT treatment centre case records, collected between 2009 and 2012, were analyzed. Most medical staff in HC-II and HC-III facilities had been made aware of HAT from radio broadcasts, newspapers and by word of mouth, suggestive of a lack of formal training. Key knowledge as regards the causative agent, clinical signs and that HAT drugs are provided free of charge was lower amongst HC-II than HC-III staff. Many respondents did not know whether HAT was endemic in their district. In rHAT specialist treatment centres, staff

  9. Conflict and human African trypanosomiasis.

    Science.gov (United States)

    Berrang-Ford, Lea; Lundine, Jamie; Breau, Sebastien

    2011-02-01

    Human African Trypanosomiasis (HAT) has reemerged in sub-Saharan Africa as a disease of major public health importance. The success of HAT elimination in sub-Saharan Africa is subject to the feasibility of controlling, eliminating, or mitigating the determinants of incidence in affected countries. Conflict has been widely recognized and cited as a contributing factor to the resurgence of HAT in many countries, as well as to continuing HAT incidence in politically unstable and resource-poor regions. Despite extensive anecdotal and qualitative recognition of the role of conflict, there has been no quantitative research of this topic at the population level in affected African countries. We characterize the qualitative and quantitative associations between HAT incidence and conflict-related processes in HAT-affected African countries over the past 30 years. HAT and conflict-related data were collected for 35 affected countries in sub-Saharan Africa for the years 1976-2004. Descriptive and univariate inferential statistics, as well as negative binomial regression modeling, are used to assess the associations between HAT and conflict. A space-time scan statistic is used to identify significant incidence clusters. Clusters of HAT incidence over the past 30 years have predominantly coincided with periods of conflict or socio-political instability. HAT cases occurred significantly more often in countries and during years with conflict, high political terror, and internationalized civil war. The results indicate a lag period between the start of conflict events and a peak in incidence of approximately 10 years. We recommend explicit consideration and quantification of socio-political measures such as conflict and terror indices in GIS (Geographic Information Systems)-based risk assessments for HAT policy and intervention. Copyright © 2010 Elsevier Ltd. All rights reserved.

  10. Die Reformdiskussion in der senegalesischen Sprachplanungs- politik

    African Journals Online (AJOL)

    Die neue Schule hat sowohl die Eigenschaften der Kanone wie des Magnets: Mit der Kanone teilte sie die Wirksamkeit einer Kampfwaffe. Besser als die Kanone es kann, verleiht die Schule der Eroberung auf Dauer. Die Kanone bezwingt nur den Leib, die Schule erobert die Seelen. […] Mit dem Magnet hat die Schule die.

  11. First Things First: Similar List Length and Output Order Effects for Verbal and Nonverbal Stimuli

    Science.gov (United States)

    Cortis, Cathleen; Dent, Kevin; Kennett, Steffan; Ward, Geoff

    2015-01-01

    When participants are presented with a short list of unrelated words and they are instructed that they may recall in any order, they nevertheless show a very strong tendency to recall in forward serial order. Thus, if asked to recall "in any orde"r: "hat, mouse, tea, stairs," participants often respond "hat, mouse, tea,…

  12. Spin Triplet Nematic Pairing Symmetry and Superconducting Double Transition in U1-xThxBe13

    Science.gov (United States)

    Machida, Kazushige

    2018-03-01

    Motivated by a recent experiment on U1-xThxBe13 with x = 3%, we develop a theory to narrow down the possible pair symmetry to consistently describe the double transition utilizing various theoretical tools, including group theory and Ginzburg-Landau theory. It is explained in terms of the two-dimensional representation Eu with spin triplet. Symmetry breaking causes the degenerate Tc to split into two. The low-temperature phase is identified as the cyclic p wave: d(k) = \\hat{x}kx + ɛ \\hat{y}ky + ɛ 2\\hat{z}kz with ɛ3 = 1, whereas the biaxial nematic phase: d(k) = √{3} (\\hat{x}kx - \\hat{y}ky) is the high-temperature one. This allows us to simultaneously identify the uniaxial nematic phase: d(k) = 2\\hat{z}kz - \\hat{x}kx - \\hat{y}ky for UBe13, which spontaneously breaks the cubic symmetry of the system. Those pair functions are fully consistent with this description and existing data. We comment on the accidental scenario in addition to this degeneracy scenario and the intriguing topological nature hidden in this long-known material.

  13. Is there a suburban sleeping sickness in Libreville?

    African Journals Online (AJOL)

    EB

    The frequent detection of sleeping sickness cases in an area not absolutely suggests that the area may be a HAT focus, since there are some rural foci with urban manifestation3. A local transmission of. HAT is confirmed when a local contact between tsetse flies and human is demonstrated (origin of tsetse blood meal) and ...

  14. Partial brood release in woodlice: A bet- hedging tactic?

    African Journals Online (AJOL)

    1994-06-06

    Jun 6, 1994 ... total brood failure (Houston & McNamara 1992), It is also possible \\hat, by delaying \\he release of part of the brood,. \\hose offspring \\hat remain behind suffer reduced morJality,. Immediately following release from \\he marsupium off- spring undergo a series of moults. It is over this time period that offspring ...

  15. Journal of Agriculture, Forestry and the Social Sciences: Submissions

    African Journals Online (AJOL)

    REFERENCES This should take the format of the current American Psychological Society Association (APA) editorial style. For Books Busola,A.E.(2004) :Hat making in the 21st Century.2nd ed.: Madandola Publishers, Calabar. For Journal articles Busola, A.E.(2004): Hat and Birthday cakes in the humid tropics of Africa and ...

  16. Human African Trypanosomiasis and challenges to its control in ...

    African Journals Online (AJOL)

    There was poor capacity for most of the health facilities in the diagnosis, treatment and control of HAT. In both districts, communities were knowledgeable of the tsetse identity (82.4%) and had experienced tsetse bites (94%). The majority (91.4%) of the community members knew that they were at risk of acquiring HAT.

  17. Arabidopsis CDS blastp result: AK241867 [KOME

    Lifescience Database Archive (English)

    Full Text Available AK241867 J065217K01 At3g13010.1 68416.m01621 hAT dimerisation domain-containing pro...tein contains Pfam profile PF04937: Protein of unknown function (DUF 659), weak hit to PF05699: hAT family dimerisation domain 1e-16 ...

  18. Arabidopsis CDS blastp result: AK241867 [KOME

    Lifescience Database Archive (English)

    Full Text Available AK241867 J065217K01 At3g22220.1 68416.m02803 hAT dimerisation domain-containing pro...tein contains Pfam profiles PF04937: Protein of unknown function (DUF 659), PF05699 hAT family dimerisation domain 8e-28 ...

  19. Arabidopsis CDS blastp result: AK241867 [KOME

    Lifescience Database Archive (English)

    Full Text Available AK241867 J065217K01 At3g13030.1 68416.m01623 hAT dimerisation domain-containing pro...tein contains Pfam profile: PF04937 domain of unknown function (DUF659), weak hit to PF05699 hAT family dimerisation domain 5e-20 ...

  20. Arabidopsis CDS blastp result: AK067280 [KOME

    Lifescience Database Archive (English)

    Full Text Available AK067280 J013103D22 At3g22220.1 hAT dimerisation domain-containing protein contains... Pfam profiles PF04937: Protein of unknown function (DUF 659), PF05699 hAT family dimerisation domain 6e-85 ...

  1. Arabidopsis CDS blastp result: AK068883 [KOME

    Lifescience Database Archive (English)

    Full Text Available AK068883 J013170M12 At1g79740.1 hAT dimerisation domain-containing protein contains... Pfam profiles: PF04937 domain of unknown function (DUF659), PF05699 hAT family dimerisation domain 1e-165 ...

  2. Arabidopsis CDS blastp result: AK101946 [KOME

    Lifescience Database Archive (English)

    Full Text Available AK101946 J033075C16 At1g79740.1 hAT dimerisation domain-containing protein contains... Pfam profiles: PF04937 domain of unknown function (DUF659), PF05699 hAT family dimerisation domain 1e-165 ...

  3. Arabidopsis CDS blastp result: AK241867 [KOME

    Lifescience Database Archive (English)

    Full Text Available AK241867 J065217K01 At1g79740.1 68414.m09302 hAT dimerisation domain-containing pro...tein contains Pfam profiles: PF04937 domain of unknown function (DUF659), PF05699 hAT family dimerisation domain 2e-30 ...

  4. Arabidopsis CDS blastp result: AK073579 [KOME

    Lifescience Database Archive (English)

    Full Text Available AK073579 J033048H06 At3g13020.1 hAT dimerisation domain-containing protein contains... Pfam profile: PF04937 domain of unknown function (DUF659), weak hit to PF05699: hAT family dimerisation domain 7e-70 ...

  5. 75 FR 45654 - Notice of Intent to Repatriate a Cultural Item: Taylor Museum of the Colorado Springs Fine Arts...

    Science.gov (United States)

    2010-08-03

    ... originally stood in front of a house, and both were used by Chief Son- i-hat, ``Southeast Wind,'' of the.... Chief Son-i-Hat also had a home not far from present-day Kasaan, which is currently the only remaining traditional Haida longhouse in Alaska. The pole was bought by a man from Los Angeles around 1908. The pole and...

  6. Precipitate coarsening parameters for gas induced semi-solid cast ...

    Indian Academy of Sciences (India)

    2017-10-31

    Oct 31, 2017 ... 2Department of Mechanical Engineering, Faculty of Engineering, Prince of Songkla University, Hat Yai, Songkhla 90112,. Thailand. 3Department of Mining and Materials Engineering, Faculty of Engineering, Prince of Songkla University, Hat Yai,. Songkhla 90112, Thailand. 4Department of Materials and ...

  7. Multiple glass transitions in the plastic crystal phase of triphenylene derivates

    NARCIS (Netherlands)

    Yildirim, Z.; Wubbenhorst, M.; Mendes, E.; Picken, S.J.; Paraschiv, I.; Marcelis, A.T.M.; Zuilhof, H.; Sudhölter, E.J.R.

    2005-01-01

    The dynamics and phase behavior of the discotic liquid crystalline compound hexahexyloxytriphenylene (HAT6) and a derivative were studied by broad-band dielectric spectroscopy, differential scanning calorimetry, X-ray diffraction and optical microscopy. While the pristine compound HAT6 forms both a

  8. Synthesis and bioactivity of novel histone acetylation inhibitors : potential new drugs for treatment of cancer and inflammation

    NARCIS (Netherlands)

    Ghizzoni, Massimo

    2011-01-01

    There is an increasing interest in histone acetyltransferases (HATs) as new therapeutic targets for treatment of diseases like, for example, inflammation and cancer. However, only few small and cell-permeable molecule inhibitors of HATs are currently available. The work described in this thesis

  9. Nucleic acid sequence-based amplification with oligochromatography for detection of Trypanosoma brucei in clinical samples

    NARCIS (Netherlands)

    Mugasa, Claire M.; Laurent, Thierry; Schoone, Gerard J.; Kager, Piet A.; Lubega, George W.; Schallig, Henk D. F. H.

    2009-01-01

    Molecular tools, such as real-time nucleic acid sequence-based amplification (NASBA) and PCR, have been developed to detect Trypanosoma brucei parasites in blood for the diagnosis of human African trypanosomiasis (HAT). Despite good sensitivity, these techniques are not implemented in HAT control

  10. Palladium-Catalyzed Atom-Transfer Radical Cyclization at Remote Unactivated C(sp3 )-H Sites: Hydrogen-Atom Transfer of Hybrid Vinyl Palladium Radical Intermediates.

    Science.gov (United States)

    Ratushnyy, Maxim; Parasram, Marvin; Wang, Yang; Gevorgyan, Vladimir

    2018-03-01

    A novel mild, visible-light-induced palladium-catalyzed hydrogen atom translocation/atom-transfer radical cyclization (HAT/ATRC) cascade has been developed. This protocol involves a 1,5-HAT process of previously unknown hybrid vinyl palladium radical intermediates, thus leading to iodomethyl carbo- and heterocyclic structures. © 2018 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

  11. Early vascular complications after pediatric liver transplantation

    NARCIS (Netherlands)

    Sieders, E; Peeters, PMJG; Ten Vergert, EM; de Jong, KP; Porte, RJ; Zwaveling, JH; Bijleveld, CMA; Slooff, MJH

    Vascular complications have a detrimental effect on the outcome after liver transplantation. Most studies focus exclusively on hepatic artery thrombosis (HAT), The current study analyzed the incidence, consequences, and risk factors for HAT, portal vein thrombosis (PVT), and venous outflow tract

  12. EPOXI EXOPLANET TRANSIT OBS - HRIV STELLAR PHOTOMETRY V1.0

    Data.gov (United States)

    National Aeronautics and Space Administration — This data set contains aperture photometry of known transiting planet systems GJ 436, HAT-P-4, HAT-P-7, TrES-2, TrES-3, and WASP-3 derived from radiance calibrated,...

  13. Resensieartikel – Germanistische Linguistik

    African Journals Online (AJOL)

    user

    Jana Luther, Fred Pheiffer en Rufus H. Gouws (Redakteurs). HAT. Hand- woordeboek van die Afrikaanse Taal. Sesde uitgawe. 2015, xviii + 1618 pp. ISBN 978-1-77025-700-9. Kaapstad: Pearson. Prys: R490. Indien jy bevrediging geput het uit die gebruik van die vorige uitgawes van die. HAT, sal jy nog meer bevrediging ...

  14. Assessment of the burden of human African trypanosomiasis by ...

    African Journals Online (AJOL)

    Background: The public health and socio-economic burden of Human African Trypanosomiasis (HAT) in East Africa is not well documented. Understanding the epidemiology and impact of HAT in such settings is difficult due to a lack of robust surveillance and reporting systems, restricting evidence-based policy ...

  15. 79 A retrospective study of Human African Trypanosomiasis in three ...

    African Journals Online (AJOL)

    (hidden) areas surrounding 'natural' game parks and reserves. ... diagnosis of HAT was made on the basis of finding trypanosomes on a thick blood film ... 100,000 (Figure 3). Figure 3: The prevalence of HAT in Malawi, 2000-2006. When individual districts were analyzed, Nkhotakota had its highest case detection rate in.

  16. Knowledge and prevalence of Human African Trypanosomiasis ...

    African Journals Online (AJOL)

    Knowledge and prevalence of Human African Trypanosomiasis among residents of Kachia grazing reserve, Kachia local government area, Kaduna state, ... Knowledge of HAT was scored 0-5 and categorized good (3-5) and poor (0-2) based on score, predisposition to risk of HAT as exposure to ≥two risk factors and, ...

  17. Detection of Trypanosoma brucei parasites in blood samples using real-time nucleic acid sequence-based amplification

    NARCIS (Netherlands)

    Mugasa, Claire M.; Schoone, Gerard J.; Ekangu, Rosine A.; Lubega, George W.; Kager, Piet A.; Schallig, Henk D. F. H.

    2008-01-01

    Currently, the conventional diagnosis of human African trypanosomiasis (HAT) is by microscopic demonstration of trypomastigotes in blood, lymph, and/or cerebrospinal fluid. However, microscopic diagnosis of HAT is not sensitive enough and may give false-negative results, thus, denying the patient

  18. Human African Trypanosomiasis in three Malawian districts | Chisi ...

    African Journals Online (AJOL)

    Human African Trypanosomiasis (HAT) is a neglected tropical disease (NTD). Surveillance in many of the endemic areas is often inadequate. Up to date information on the HAT situation in Malawi, where the disease is endemic in some districts, provides opportunity to raise the profile of the disease and interest in ...

  19. Histone acetyltransferases : challenges in targeting bi-substrate enzymes

    NARCIS (Netherlands)

    Wapenaar, Hannah; Dekker, Frank J

    2016-01-01

    Histone acetyltransferases (HATs) are epigenetic enzymes that install acetyl groups onto lysine residues of cellular proteins such as histones, transcription factors, nuclear receptors, and enzymes. HATs have been shown to play a role in diseases ranging from cancer and inflammatory diseases to

  20. Bericht am Feuer. Gespräche, E-Mails und Telefonate zum Werk von Christoph Ransmayr von Insa Wilke (Hg.

    Directory of Open Access Journals (Sweden)

    Johanna Lenhart

    2014-09-01

    Full Text Available Christoph Ransmayr baut seine Bücher immer ausgehend von Gesprächen auf. Anlässlich seines 60. Geburtstags hat Insa Wilke einen Materialienband herausgegeben, den Johanna Lenhart für die MEDIENIMPULSE rezensiert hat

  1. 16 CFR 1609.1 - Text of the Flammable Fabrics Act of 1953, as amended in 1954.

    Science.gov (United States)

    2010-01-01

    ..., as amended in 1954. 1609.1 Section 1609.1 Commercial Practices CONSUMER PRODUCT SAFETY COMMISSION... be worn by individuals except hats, gloves, and footwear: Provided, however, That such hats do not... form an integral part of another garment: And provided further, That such footwear does not consist of...

  2. 16 CFR 1611.36 - Application of act to particular types of products.

    Science.gov (United States)

    2010-01-01

    ... products. 1611.36 Section 1611.36 Commercial Practices CONSUMER PRODUCT SAFETY COMMISSION FLAMMABLE FABRICS... intended or sold for use in those hats, gloves, and footwear which are excluded under the definition of..., and any person manufacturing hats, gloves, or footwear containing such fabrics maintains records which...

  3. Expression profiling of S. pombe acetyltransferase mutants identifies redundant pathways of gene regulation

    Directory of Open Access Journals (Sweden)

    Wright Anthony PH

    2010-01-01

    Full Text Available Abstract Background Histone acetyltransferase enzymes (HATs are implicated in regulation of transcription. HATs from different families may overlap in target and substrate specificity. Results We isolated the elp3+ gene encoding the histone acetyltransferase subunit of the Elongator complex in fission yeast and characterized the phenotype of an Δelp3 mutant. We examined genetic interactions between Δelp3 and two other HAT mutants, Δmst2 and Δgcn5 and used whole genome microarray analysis to analyze their effects on gene expression. Conclusions Comparison of phenotypes and expression profiles in single, double and triple mutants indicate that these HAT enzymes have overlapping functions. Consistent with this, overlapping specificity in histone H3 acetylation is observed. However, there is no evidence for overlap with another HAT enzyme, encoded by the essential mst1+ gene.

  4. New Insights in Staging and Chemotherapy of African Trypanosomiasis and Possible Contribution of Medicinal Plants

    Directory of Open Access Journals (Sweden)

    Paul F. Seke Etet

    2012-01-01

    Full Text Available Human African trypanosomiasis (HAT is a fatal if untreated fly-borne neuroinflammatory disease caused by protozoa of the species Trypanosoma brucei (T.b.. The increasing trend of HAT cases has been reversed, but according to WHO experts, new epidemics of this disease could appear. In addition, HAT is still a considerable burden for life quality and economy in 36 sub-Saharan Africa countries with 15–20 million persons at risk. Following joined initiatives of WHO and private partners, the fight against HAT was re-engaged, resulting in considerable breakthrough. We present here what is known at this day about HAT etiology and pathogenesis and the new insights in the development of accurate tools and tests for disease staging and severity monitoring in the field. Also, we elaborate herein the promising progresses made in the development of less toxic and more efficient trypanocidal drugs including the potential of medicinal plants and related alternative drug therapies.

  5. Mathematical models of human african trypanosomiasis epidemiology.

    Science.gov (United States)

    Rock, Kat S; Stone, Chris M; Hastings, Ian M; Keeling, Matt J; Torr, Steve J; Chitnis, Nakul

    2015-03-01

    Human African trypanosomiasis (HAT), commonly called sleeping sickness, is caused by Trypanosoma spp. and transmitted by tsetse flies (Glossina spp.). HAT is usually fatal if untreated and transmission occurs in foci across sub-Saharan Africa. Mathematical modelling of HAT began in the 1980s with extensions of the Ross-Macdonald malaria model and has since consisted, with a few exceptions, of similar deterministic compartmental models. These models have captured the main features of HAT epidemiology and provided insight on the effectiveness of the two main control interventions (treatment of humans and tsetse fly control) in eliminating transmission. However, most existing models have overestimated prevalence of infection and ignored transient dynamics. There is a need for properly validated models, evolving with improved data collection, that can provide quantitative predictions to help guide control and elimination strategies for HAT. Copyright © 2015 Elsevier Ltd. All rights reserved.

  6. New Insights in Staging and Chemotherapy of African Trypanosomiasis and Possible Contribution of Medicinal Plants

    Science.gov (United States)

    Seke Etet, Paul F.; Fawzi Mahomoodally, M.

    2012-01-01

    Human African trypanosomiasis (HAT) is a fatal if untreated fly-borne neuroinflammatory disease caused by protozoa of the species Trypanosoma brucei (T.b.). The increasing trend of HAT cases has been reversed, but according to WHO experts, new epidemics of this disease could appear. In addition, HAT is still a considerable burden for life quality and economy in 36 sub-Saharan Africa countries with 15–20 million persons at risk. Following joined initiatives of WHO and private partners, the fight against HAT was re-engaged, resulting in considerable breakthrough. We present here what is known at this day about HAT etiology and pathogenesis and the new insights in the development of accurate tools and tests for disease staging and severity monitoring in the field. Also, we elaborate herein the promising progresses made in the development of less toxic and more efficient trypanocidal drugs including the potential of medicinal plants and related alternative drug therapies. PMID:22593674

  7. Assessing the capacity to diagnose human African trypanosomiasis among health care personnel from Chama and Mambwe districts of eastern Zambia.

    Science.gov (United States)

    Mulenga, Gloria M; Likwa, Rosemary N; Namangala, Boniface

    2015-09-11

    Human African Trypanosomiasis (HAT) is a neglected tropical disease affecting poor rural communities living in tsetse-infested regions of sub-Saharan Africa. In Zambia, sporadic cases of HAT have been reported mainly in the old foci along the tsetse-infested Luangwa river valley in north-eastern part of the country. In such places where malaria is the major endemic febrile disease, with possibilities of co-infections of HAT and malaria and where the levels of alertness to the presence of HAT among health care personnel (HCP) is low, there is a high chance of misdiagnosing HAT for malaria because of their similarities in clinical presentation. This study, conducted in Zambia's tsetse-infested rural health centres (RHCs) of Chama and Mambwe districts, was designed to investigate the staffing levels, the HCP levels of alertness to the occurrence of HAT and their capacity to detect the disease. Structured questionnaires were used to collect information pertaining to HAT alertness and the capacity to detect the disease from 101 HCP in a cross sectional study of 23 RHCs drawn from Zambia's Chama and Mambwe districts between April and July 2013. The data collected were analyzed using Stata/SE version 11.0. Participants from both Chama and Mambwe district RHCs reported similar very low levels of qualified HCP and laboratory technicians, and that they had similar basic tools for HAT diagnosis. Although not statistically significant, respondents from Chama (~89%) tended to be more aware about the occurrence of HAT compared to their Mambwe counterparts (~78%). Whereas ~40% of the HCP from Chama district (n = 52) claimed to have encountered at least one case of HAT, only ~4% of their Mambwe counterparts (n = 49) had similar experiences (P = 0.000). Health care personnel in RHCs from Chama tended to be more alert to the occurrence of HAT than the HCP from Mambwe district. The extremely low levels of categorized HCP, general absence of functional laboratories, coupled with

  8. Application of Human-Autonomy Teaming to an Advanced Ground Station for Reduced Crew Operations

    Science.gov (United States)

    Ho, Nhut; Johnson, Walter; Panesar, Karanvir; Wakeland, Kenny; Sadler, Garrett; Wilson, Nathan; Nguyen, Bao; Lachter, Joel; Stallmann, Summer

    2017-01-01

    Within human factors there is burgeoning interest in the "human-autonomy teaming" (HAT) concept as a way to address the challenges of interacting with complex, increasingly autonomous systems. The HAT concept comes out of an aspiration to interact with increasingly autonomous systems as a team member, rather than simply use automation as a tool. The authors, and others, have proposed core tenets for HAT that include bi-directional communication, automation and system transparency, and advanced coordination between human and automated teammates via predefined, dynamic task sequences known as "plays." It is believed that, with proper implementation, HAT should foster appropriate teamwork, thus increasing trust and reliance on the system, which in turn will reduce workload, increase situation awareness, and improve performance. To this end, HAT has been demonstrated and/or studied in multiple applications including search and rescue operations, healthcare and medicine, autonomous vehicles, photography, and aviation. The current paper presents one such effort to apply HAT. It details the design of a HAT agent, developed by Human Automation Teaming Solutions, Inc., to facilitate teamwork between the automation and the human operator of an advanced ground dispatch station. This dispatch station was developed to support a NASA project investigating a concept called Reduced Crew Operations (RCO); consequently, we have named the agent R-HATS. Part of the RCO concept involves a ground operator providing enhanced support to a large number of aircraft with a single pilot on the flight deck. When assisted by R-HATS, operators can monitor and support or manage a large number of aircraft and use plays to respond in real-time to complicated, workload-intensive events (e.g., an airport closure). A play is a plan that encapsulates goals, tasks, and a task allocation strategy appropriate for a particular situation. In the current implementation, when a play is initiated by a user, R-HATS

  9. A munkaerő-piaci politika hatása a nemek közötti egyenlőségre a gazdasági átalakulás és az EU-csatlakozás időszakában: Csehország, Magyarország és Szlovénia összehasonlítása

    Czech Academy of Sciences Publication Activity Database

    Nagy, B.; Křížková, Alena; Kanjuo-Mrčela, A.

    2012-01-01

    Roč. 22, č. 1 (2012), s. 30-60 ISSN 1216-2051 R&D Projects: GA ČR GAP404/10/0021 Institutional support: RVO:68378025 Keywords : female employment * gender equality * child care institutions Subject RIV: AO - Sociology, Demography

  10. Factorizing the time evolution operator

    International Nuclear Information System (INIS)

    Garcia Quijas, P C; Arevalo Aguilar, L M

    2007-01-01

    There is a widespread belief in the quantum physical community, and textbooks used to teach quantum mechanics, that it is a difficult task to apply the time evolution operator e itH-hat/h on an initial wavefunction. Because the Hamiltonian operator is, generally, the sum of two operators, then it is not possible to apply the time evolution operator on an initial wavefunction ψ(x, 0), for it implies using terms like (a-hat + b-hat). A possible solution is to factorize the time evolution operator and then apply successively the individual exponential operator on the initial wavefunction. However, the exponential operator does not directly factorize, i.e. e a-hat+b-hat ≠ e a-hat e b-hat . In this study we present a useful procedure for factorizing the time evolution operator when the argument of the exponential is a sum of two operators, which obey specific commutation relations. Then, we apply the exponential operator as an evolution operator for the case of elementary unidimensional potentials, like a particle subject to a constant force and a harmonic oscillator. Also, we discuss an apparent paradox concerning the time evolution operator and non-spreading wave packets addressed previously in the literature

  11. Quantum-Classical Phase Transition of the Escape Rate of Two-Sublattice Antiferromagnetic Large Spins

    Science.gov (United States)

    Owerre, Solomon Akaraka; Paranjape, M. B.

    2014-11-01

    The Hamiltonian of a two-sublattice antiferromagnetic spins, with single (hard-axis) and double ion anisotropies described by H = J {\\hat S}1...\\hatS 2-2Jz \\hat {S}1z\\hat {S}2z+K(\\hat {S}1z2 +\\hat {S}2z2) is investigated using the method of effective potential. The problem is mapped to a single particle quantum-mechanical Hamiltonian in terms of the relative coordinate and reduced mass. We study the quantum-classical phase transition of the escape rate of this model. We show that the first-order phase transition for this model sets in at the critical value Jc = (Kc+Jz, c)/2 while for the anisotropic Heisenberg coupling H = J(S1xS2x +S1yS2y) + JzS1zS2z + K(S1z2+ S2z2) we obtain Jc = (2Kc-Jz, c)/3. The phase diagrams of the transition are also studied.

  12. Human African trypanosomiasis in South Sudan: how can we prevent a new epidemic?

    Directory of Open Access Journals (Sweden)

    José A Ruiz-Postigo

    Full Text Available Human African trypanosomiasis (HAT has been a major public health problem in South Sudan for the last century. Recurrent outbreaks with a repetitive pattern of responding-scaling down activities have been observed. Control measures for outbreak response were reduced when the prevalence decreased and/or socio-political crisis erupted, leading to a new increase in the number of cases. This paper aims to raise international awareness of the threat of another outbreak of sleeping sickness in South Sudan. It is a review of the available data, interventions over time, and current reports on the status of HAT in South Sudan. Since 2006, control interventions and treatments providing services for sleeping sickness have been reduced. Access to HAT diagnosis and treatment has been considerably diminished. The current status of control activities for HAT in South Sudan could lead to a new outbreak of the disease unless 1 the remaining competent personnel are used to train younger staff to resume surveillance and treatment in the centers where HAT activities have stopped, and 2 control of HAT continues to be given priority even when the number of cases has been substantially reduced. Failure to implement an effective and sustainable system for HAT control and surveillance will increase the risk of a new epidemic. That would cause considerable suffering for the affected population and would be an impediment to the socioeconomic development of South Sudan.

  13. Human-Autonomy Teaming in a Flight Following Task

    Science.gov (United States)

    Shively, Robert J.

    2017-01-01

    The NATO HFM-247 Working Group is creating a summary report of the group's activities on human-autonomy teaming. This chapter is a summary of our at NASA Ames work toward developing a framework for human-autonomy teaming (HAT) in aviation. The purpose of this project was to demonstrate and evaluate proposed tenets of HAT. The HAT features were derived from three tenets and were built into an automated recommender system on a ground station. These tenets include bi-directional communication, automation transparency, and operator directed interface. This study focused primarily on interactions with one piece of automation, the Autonomous Constrained Flight Planner (ACFP). The ACFP is designed to support rapid diversion decisions for commercial pilots in off-nominal situations. Much effort has gone into enhancing this tool not only in capability but also in transparency. In this study, participants used the ACFP at a ground station designed to aid dispatchers in a flight following role to reroute aircraft in situations such as inclement weather, system failures and medical emergencies. Participants performed this task both with HAT features enabled and without and provided feedback. We examined subjective and behavioral indicators of HAT collaborations using a proof-of-concept demonstration of HAT tenets. The data collected suggest potential advantages and disadvantages of HAT.

  14. Development of multiplex serological assay for the detection of human African trypanosomiasis.

    Science.gov (United States)

    Nzou, Samson Muuo; Fujii, Yoshito; Miura, Masashi; Mwau, Matilu; Mwangi, Anne Wanjiru; Itoh, Makoto; Salam, Md Abdus; Hamano, Shinjiro; Hirayama, Kenji; Kaneko, Satoshi

    2016-04-01

    Human African trypanosomiasis (HAT) is a disease caused by Kinetoplastid infection. Serological tests are useful for epidemiological surveillance. The aim of this study was to develop a multiplex serological assay for HAT to assess the diagnostic value of selected HAT antigens for sero-epidemiological surveillance. We cloned loci encoding eight antigens from Trypanosoma brucei gambiense, expressed the genes in bacterial systems, and purified the resulting proteins. Antigens were subjected to Luminex multiplex assays using sera from HAT and VL patients to assess the antigens' immunodiagnostic potential. Among T. b. gambiense antigens, the 64-kDa and 65-kDa invariant surface glycoproteins (ISGs) and flagellar calcium binding protein (FCaBP) had high sensitivity for sera from T. b. gambiense patients, yielding AUC values of 0.871, 0.737 and 0.858 respectively in receiver operating characteristics (ROC) analysis. The ISG64, ISG65, and FCaBP antigens were partially cross-reactive to sera from Trypanosoma brucei rhodesiense patients. The GM6 antigen was cross-reactive to sera from T. b. rhodesiense patients as well as to sera from VL patients. Furthermore, heterogeneous antibody responses to each individual HAT antigen were observed. Testing for multiple HAT antigens in the same panel allowed specific and sensitive detection. Our results demonstrate the utility of applying multiplex assays for development and evaluation of HAT antigens for use in sero-epidemiological surveillance. Copyright © 2015 The Authors. Published by Elsevier Ireland Ltd.. All rights reserved.

  15. Inner Core Anisotropy: Can Seismic Observations be Reconciled with Ab Initio Calculations of Elasticity?

    Science.gov (United States)

    Song, X.; Jordan, T. H.

    2016-12-01

    Body-wave and normal-mode observations have revealed an inner-core structure that is radially layered, axially anisotropic, and hemispherically asymmetric. Previous theoretical studies have examined the consistency of these features with the elasticity of iron crystals thought to dominate inner-core composition, but a fully consistent model has been elusive. Here we compare the seismic observation with effective-medium models derived from ab initio calculations of the elasticity tensors for hcp-Fe and bcc-Fe. Our estimates are based on Jordan's (GJI, 2015) effective medium theory, which is derived from a self-consistent, second-order Born approximation. The theory provides closed-form expressions for the effective elastic parameters of 3D anisotropic, heterogeneous media in which the local anisotropy is a constant hexagonal stiffness tensor C stochastically oriented about a constant symmetry axis \\hat{s} and the statistics of the small-scale heterogeneities are transversely isotropic in the plane perpendicular to \\hat{s}. The stochastic model is then described by a dimensionless "aspect ratio of the heterogeneity", 0 ≤ η body-wave observations, then these hcp-Fe models predict that the fast polarization of the S waves is in the plane perpendicular to \\hat{s}, which disagrees with most normal-mode models. We have attempted to resolve this discrepancy by examining alternative hcp-Fe models, including radially anisotropic distributions of stochastic anisotropy and heterogeneity (i.e., where \\hat{s} = \\hat{r}), as well as bcc-Fe models. Our calculations constrain the form of C needed to satisfy the seismological inferences.

  16. Evaluation of the diagnostic accuracy of prototype rapid tests for human African trypanosomiasis.

    Directory of Open Access Journals (Sweden)

    Jeremy M Sternberg

    2014-12-01

    Full Text Available Diagnosis of human African trypanosomiasis (HAT remains a challenge both for active screening, which is critical in control of the disease, and in the point-of-care scenario where early and accurate diagnosis is essential. Recently, the first field deployment of a lateral flow rapid diagnostic test (RDT for HAT, "SD BIOLINE HAT" has taken place. In this study, we evaluated the performance of "SD BIOLINE HAT" and two new prototype RDTs.The performance of "SD BIOLINE HAT" and 2 prototype RDTs was tested using archived plasma from 250 Trypanosoma brucei gambiense patients, and 250 endemic controls. As well as comparison of the sensitivity and specificity of each device, the performance of individual antigens was assessed and the hypothetical performance of novel antigen combinations extrapolated. Neither of the prototype devices were inferior in sensitivity or specificity to "SD BIOLINE HAT" (sensitivity 0.82±0.01, specificity 0.97±0.01, 95% CI at the 5% margins, while one of the devices (BBI had significantly superior sensitivity (0.88±0.03. Analysis of the performance of individual antigens was used to model new antigen combinations to be explored in development of the next generation of HAT RDTs. The modelling showed that an RDT using two recombinant antigens (rLiTat1.5 and rISG65 would give a performance similar to the best devices in this study, and would also offer the most robust performance under deteriorating field conditions.Both "SD BIOLINE HAT" and the prototype devices performed comparably well to one another and also to the published performance range of the card agglutination test for trypanosomiasis in sensitivity and specificity. The performance of individual antigens enabled us to predict that an all-recombinant antigen RDT can be developed with an accuracy equivalent to " SD BIOLINE HAT." Such an RDT would have advantages in simplified manufacture, lower unit cost and assured reproducibility.

  17. Enhanced passive screening and diagnosis for gambiense human African trypanosomiasis in north-western Uganda - Moving towards elimination.

    Directory of Open Access Journals (Sweden)

    Charles Wamboga

    Full Text Available The incidence of gambiense human African trypanosomiasis (gHAT in Uganda has been declining, from 198 cases in 2008, to only 20 in 2012. Interruption of transmission of the disease by early diagnosis and treatment is core to the control and eventual elimination of gHAT. Until recently, the format of available screening tests had restricted screening and diagnosis to central health facilities (passive screening. We describe a novel strategy that is contributing to elimination of gHAT in Uganda through expansion of passive screening to the entire population at risk.In this strategy, patients who are clinically suspected of having gHAT at primary health facilities are screened using a rapid diagnostic test (RDT, followed by parasitological confirmation at strategically located microscopy centres. For patients who are positive with the RDT and negative by microscopy, blood samples undergo further testing using loop-mediated isothermal amplification (LAMP, a molecular test that detects parasite DNA. LAMP positive patients are considered strong suspects, and are re-evaluated by microscopy. Location and upgrading of facilities to perform microscopy and LAMP was informed by results of georeferencing and characterization of all public healthcare facilities in the 7 gHAT endemic districts in Uganda. Three facilities were upgraded to perform RDTs, microscopy and LAMP, 9 to perform RDTs and microscopy, and 200 to screen patients with RDTs. This reduced the distance that a sick person must travel to be screened for gHAT to a median distance of 2.5km compared to 23km previously. In this strategy, 9 gHAT cases were diagnosed in 2014, and 4 in 2015.This enhanced passive screening strategy for gHAT has enabled full coverage of the population at risk, and is being replicated in other gHAT endemic countries. The improvement in case detection is making elimination of the disease in Uganda an imminent possibility.

  18. The Changing Epidemiology of Human African Trypanosomiasis among Patients from Nonendemic Countries –1902–2012

    Science.gov (United States)

    Neuberger, Ami; Meltzer, Eyal; Leshem, Eyal; Dickstein, Yaakov; Stienlauf, Shmuel; Schwartz, Eli

    2014-01-01

    Background Although human African trypanosomiasis (HAT) is uncommon among patients from non-endemic countries (NEC), there has been an increase in the number of cases reported in recent years. Methods A systematic review of the literature was performed. The number of incoming tourists to HAT endemic countries was obtained from the United Nations World Tourism Organization. All HAT cases diagnosed in patients from NEC were included. Immigrants and refugees were excluded. We compared patients during and after the colonial period, and analyzed the relationship between the number of incoming travellers and the number of HAT cases. Results Between 1902 and 2012, HAT was reported in 244 patients. Most HAT cases were reported before 1920, and after the year 2000. In the colonial era the average age of patients was lower (32.5±7.8 vs. 43.0±16.1 years, Ptrypanosomiasis accounted for 86/110, (78%) of cases. In the post-colonial era most patients 91/125 (72.8%) were short-term tourists to game parks in Eastern and South-Eastern Africa (mainly in Tanzania); Rhodesian trypanosomiasis accounted for 94/123 (76.4%) of cases. Between 1995 and 2010 there has been a constant linear increase in the number of incoming tourists to Tanzania, and HAT cases occurred in small outbreaks rather than following a similar linear pattern. Conclusions In recent decades HAT patients from NEC are older, and more likely to be tourists who acquired the disease while visiting game-parks in Eastern and South-Eastern Africa. While Rhodesian trypanosomiasis is relatively uncommon among Africans, it now accounts for most cases reported among patients from NEC. Returning febrile travellers without an alternative diagnosis should be evaluated for HAT. Cases among travellers may serve as sentinels for Rhodesian trypanosomiasis “hot spots” in Africa. PMID:24586363

  19. The changing epidemiology of human African trypanosomiasis among patients from nonendemic countries--1902-2012.

    Science.gov (United States)

    Neuberger, Ami; Meltzer, Eyal; Leshem, Eyal; Dickstein, Yaakov; Stienlauf, Shmuel; Schwartz, Eli

    2014-01-01

    Although human African trypanosomiasis (HAT) is uncommon among patients from non-endemic countries (NEC), there has been an increase in the number of cases reported in recent years. A systematic review of the literature was performed. The number of incoming tourists to HAT endemic countries was obtained from the United Nations World Tourism Organization. All HAT cases diagnosed in patients from NEC were included. Immigrants and refugees were excluded. We compared patients during and after the colonial period, and analyzed the relationship between the number of incoming travellers and the number of HAT cases. Between 1902 and 2012, HAT was reported in 244 patients. Most HAT cases were reported before 1920, and after the year 2000. In the colonial era the average age of patients was lower (32.5±7.8 vs. 43.0±16.1 years, Ptrypanosomiasis accounted for 86/110, (78%) of cases. In the post-colonial era most patients 91/125 (72.8%) were short-term tourists to game parks in Eastern and South-Eastern Africa (mainly in Tanzania); Rhodesian trypanosomiasis accounted for 94/123 (76.4%) of cases. Between 1995 and 2010 there has been a constant linear increase in the number of incoming tourists to Tanzania, and HAT cases occurred in small outbreaks rather than following a similar linear pattern. In recent decades HAT patients from NEC are older, and more likely to be tourists who acquired the disease while visiting game-parks in Eastern and South-Eastern Africa. While Rhodesian trypanosomiasis is relatively uncommon among Africans, it now accounts for most cases reported among patients from NEC. Returning febrile travellers without an alternative diagnosis should be evaluated for HAT. Cases among travellers may serve as sentinels for Rhodesian trypanosomiasis "hot spots" in Africa.

  20. Enhanced passive screening and diagnosis for gambiense human African trypanosomiasis in north-western Uganda - Moving towards elimination.

    Science.gov (United States)

    Wamboga, Charles; Matovu, Enock; Bessell, Paul Richard; Picado, Albert; Biéler, Sylvain; Ndung'u, Joseph Mathu

    2017-01-01

    The incidence of gambiense human African trypanosomiasis (gHAT) in Uganda has been declining, from 198 cases in 2008, to only 20 in 2012. Interruption of transmission of the disease by early diagnosis and treatment is core to the control and eventual elimination of gHAT. Until recently, the format of available screening tests had restricted screening and diagnosis to central health facilities (passive screening). We describe a novel strategy that is contributing to elimination of gHAT in Uganda through expansion of passive screening to the entire population at risk. In this strategy, patients who are clinically suspected of having gHAT at primary health facilities are screened using a rapid diagnostic test (RDT), followed by parasitological confirmation at strategically located microscopy centres. For patients who are positive with the RDT and negative by microscopy, blood samples undergo further testing using loop-mediated isothermal amplification (LAMP), a molecular test that detects parasite DNA. LAMP positive patients are considered strong suspects, and are re-evaluated by microscopy. Location and upgrading of facilities to perform microscopy and LAMP was informed by results of georeferencing and characterization of all public healthcare facilities in the 7 gHAT endemic districts in Uganda. Three facilities were upgraded to perform RDTs, microscopy and LAMP, 9 to perform RDTs and microscopy, and 200 to screen patients with RDTs. This reduced the distance that a sick person must travel to be screened for gHAT to a median distance of 2.5km compared to 23km previously. In this strategy, 9 gHAT cases were diagnosed in 2014, and 4 in 2015. This enhanced passive screening strategy for gHAT has enabled full coverage of the population at risk, and is being replicated in other gHAT endemic countries. The improvement in case detection is making elimination of the disease in Uganda an imminent possibility.

  1. Geometric Weil representation in characteristic two

    OpenAIRE

    Genestier, Alain; Lysenko, Sergey

    2009-01-01

    International audience; Let k be an algebraically closed field of characteristic two. Let R be the ring of Witt vectors of length two over k. We construct a group stack \\hat G over k, the metaplectic extension of the Greenberg realization of Sp_{2n}(R). We also construct a geometric analog of the Weil representation of \\hat G, this is a triangulated category on which \\hat G acts by functors. This triangulated category and the action are geometric in a suitable sense.

  2. Von der konventionellen laparoskopischen Prostatektomie zur DaVinci-Prostatektomie

    Directory of Open Access Journals (Sweden)

    Fehr JL

    2006-01-01

    Full Text Available Die Operationstechnik der radikalen Prostatektomie hat sich in den letzten 20 Jahren grundlegend verändert. Einerseits hat sich die Technik verfeinert und berücksichtigt die neuesten anatomischen Erkenntnisse der Prostata (Sphinkterapparat, Gefäßnervenbahnen, andererseits hat sich der minimalinvasive Zugang mittels Laparoskopie etabliert und findet nun mit der Roboterunterstützung (DaVinci-Technologie eine weitere Verbreitung. Die Autoren berichten über ihre Erfahrungen beim Wechsel von der konventionellen laparoskopischen Prostatektomie zur laparoskopischen DaVinci-Prostatektomie.

  3. Challenges of controlling sleeping sickness in areas of violent conflict: experience in the Democratic Republic of Congo

    Directory of Open Access Journals (Sweden)

    Yun Oliver

    2011-05-01

    Full Text Available Abstract Background Human African trypanosomiasis (HAT, or sleeping sickness, is a fatal neglected tropical disease if left untreated. HAT primarily affects people living in rural sub-Saharan Africa, often in regions afflicted by violent conflict. Screening and treatment of HAT is complex and resource-intensive, and especially difficult in insecure, resource-constrained settings. The country with the highest endemicity of HAT is the Democratic Republic of Congo (DRC, which has a number of foci of high disease prevalence. We present here the challenges of carrying out HAT control programmes in general and in a conflict-affected region of DRC. We discuss the difficulties of measuring disease burden, medical care complexities, waning international support, and research and development barriers for HAT. Discussion In 2007, Médecins Sans Frontières (MSF began screening for HAT in the Haut-Uélé and Bas-Uélé districts of Orientale Province in northeastern DRC, an area of high prevalence affected by armed conflict. Through early 2009, HAT prevalence rate of 3.4% was found, reaching 10% in some villages. More than 46,000 patients were screened and 1,570 treated for HAT during this time. In March 2009, two treatment centres were forced to close due to insecurity, disrupting patient treatment, follow-up, and transmission-control efforts. One project was reopened in December 2009 when the security situation improved, and another in late 2010 based on concerns that population displacement might reactivate historic foci. In all of 2010, 770 patients were treated at these sites, despite a limited geographical range of action for the mobile teams. Summary In conflict settings where HAT is prevalent, targeted medical interventions are needed to provide care to the patients caught in these areas. Strategies of integrating care into existing health systems may be unfeasible since such infrastructure is often absent in resource-poor contexts. HAT care in

  4. Tsetse Flies (Glossina as Vectors of Human African Trypanosomiasis: A Review

    Directory of Open Access Journals (Sweden)

    Florence Njeri Wamwiri

    2016-01-01

    Full Text Available Human African Trypanosomiasis (HAT transmitted by the tsetse fly continues to be a public health issue, despite more than a century of research. There are two types of the disease, the chronic gambiense and the acute rhodesiense-HAT. Fly abundance and distribution have been affected by changes in land-use patterns and climate. However, disease transmission still continues. Here, we review some aspects of HAT ecoepidemiology in the context of altered infestation patterns and maintenance of the transmission cycle as well as emerging options in disease and vector control.

  5. Tsetse Flies (Glossina) as Vectors of Human African Trypanosomiasis: A Review.

    Science.gov (United States)

    Wamwiri, Florence Njeri; Changasi, Robert Emojong

    2016-01-01

    Human African Trypanosomiasis (HAT) transmitted by the tsetse fly continues to be a public health issue, despite more than a century of research. There are two types of the disease, the chronic gambiense and the acute rhodesiense-HAT. Fly abundance and distribution have been affected by changes in land-use patterns and climate. However, disease transmission still continues. Here, we review some aspects of HAT ecoepidemiology in the context of altered infestation patterns and maintenance of the transmission cycle as well as emerging options in disease and vector control.

  6. Estimating the burden of rhodesiense sleeping sickness during an outbreak in Serere, eastern Uganda

    Directory of Open Access Journals (Sweden)

    Coleman Paul G

    2008-03-01

    Full Text Available Abstract Background Zoonotic sleeping sickness, or HAT (Human African Trypanosomiasis, caused by infection with Trypanosoma brucei rhodesiense, is an under-reported and neglected tropical disease. Previous assessments of the disease burden expressed as Disability-Adjusted Life Years (DALYs for this infection have not distinguished T.b. rhodesiense from infection with the related, but clinically distinct Trypanosoma brucei gambiense form. T.b. rhodesiense occurs focally, and it is important to assess the burden at the scale at which resource-allocation decisions are made. Methods The burden of T.b. rhodesiense was estimated during an outbreak of HAT in Serere, Uganda. We identified the unique characteristics affecting the burden of rhodesiense HAT such as age, severity, level of under-reporting and duration of hospitalisation, and use field data and empirical estimates of these to model the burden imposed by this and other important diseases in this study population. While we modelled DALYs using standard methods, we also modelled uncertainty of our parameter estimates through a simulation approach. We distinguish between early and late stage HAT morbidity, and used disability weightings appropriate for the T.b. rhodesiense form of HAT. We also use a model of under-reporting of HAT to estimate the contribution of un-reported mortality to the overall disease burden in this community, and estimate the cost-effectiveness of hospital-based HAT control. Results Under-reporting accounts for 93% of the DALY estimate of rhodesiense HAT. The ratio of reported malaria cases to reported HAT cases in the same health unit was 133:1, however, the ratio of DALYs was 3:1. The age productive function curve had a close correspondence with the HAT case distribution, and HAT cases occupied more patient admission time in Serere during 1999 than all other infectious diseases other than malaria. The DALY estimate for HAT in Serere shows that the burden is much greater

  7. How can molecular diagnostics contribute to the elimination of human African trypanosomiasis?

    Science.gov (United States)

    Büscher, Philippe; Deborggraeve, Stijn

    2015-05-01

    A variety of molecular diagnostic tests for human African trypanosomiasis (HAT) (sleeping sickness) has been developed. Some are effectively used for research and confirmation diagnosis in travel medicine, usually following non-standardized protocols. Others have become commercially available as diagnostic kits. WHO aims to eliminate HAT as a public health problem by the year 2020, and zero transmission by the year 2030. This article gives an overview of the recent progress in molecular diagnostics for sleeping sickness, including the most recent data on test performances. Also discussed is how molecular diagnostics can play an important role in the process toward the elimination of HAT.

  8. Challenges of controlling sleeping sickness in areas of violent conflict: experience in the Democratic Republic of Congo.

    Science.gov (United States)

    Tong, Jacqueline; Valverde, Olaf; Mahoudeau, Claude; Yun, Oliver; Chappuis, François

    2011-05-26

    Human African trypanosomiasis (HAT), or sleeping sickness, is a fatal neglected tropical disease if left untreated. HAT primarily affects people living in rural sub-Saharan Africa, often in regions afflicted by violent conflict. Screening and treatment of HAT is complex and resource-intensive, and especially difficult in insecure, resource-constrained settings. The country with the highest endemicity of HAT is the Democratic Republic of Congo (DRC), which has a number of foci of high disease prevalence. We present here the challenges of carrying out HAT control programmes in general and in a conflict-affected region of DRC. We discuss the difficulties of measuring disease burden, medical care complexities, waning international support, and research and development barriers for HAT. In 2007, Médecins Sans Frontières (MSF) began screening for HAT in the Haut-Uélé and Bas-Uélé districts of Orientale Province in northeastern DRC, an area of high prevalence affected by armed conflict. Through early 2009, HAT prevalence rate of 3.4% was found, reaching 10% in some villages. More than 46,000 patients were screened and 1,570 treated for HAT during this time. In March 2009, two treatment centres were forced to close due to insecurity, disrupting patient treatment, follow-up, and transmission-control efforts. One project was reopened in December 2009 when the security situation improved, and another in late 2010 based on concerns that population displacement might reactivate historic foci. In all of 2010, 770 patients were treated at these sites, despite a limited geographical range of action for the mobile teams. In conflict settings where HAT is prevalent, targeted medical interventions are needed to provide care to the patients caught in these areas. Strategies of integrating care into existing health systems may be unfeasible since such infrastructure is often absent in resource-poor contexts. HAT care in conflict areas must balance logistical and medical capacity

  9. Exposición al humo ambiental del tabaco y medidas de control del tabaquismo

    OpenAIRE

    Martínez Sánchez, José M.

    2010-01-01

    [spa] Antecedentes: En España, hasta 3.200 defunciones anuales son atribuidas al tabaquismo pasivo. La exposición al humo ambiental del tabaco (HAT) aumenta el riesgo de padecer enfermedades crónicas como cáncer de pulmón, enfermedades cardiovasculares y enfermedades respiratorias. Hipótesis: 1) Existe una relación entre la exposición al HAT medida mediante cuestionario y la concentración de cotinina en saliva. 2) La exposición al HAT y la concentración de cotinina en saliva es mayor en l...

  10. Characterization of High Altitude Turbulence for Air Force Platforms

    National Research Council Canada - National Science Library

    Ruggiero, Frank H; Werne, Joe; Mahalov, Alex; Nichols, Basil; Wroblewski, Donald E

    2007-01-01

    ...) on systems that operate at or propagate through those attitudes. Examples of systems affected by HAT include surveillance aircraft such as the U-2 and the unmanned Global Hawk, developing weapons systems such as the Airborne Laser (ABL...

  11. 5 CFR 591.102 - Definitions.

    Science.gov (United States)

    2010-01-01

    ... limited to, such items as shoes, boots, hats, shirts, slacks, skirts, or outerwear an employee is required... U.S.C. 7903 or normal business or work attire purchased at the discretion of the employee. Year...

  12. Safety audits/Verkehrssicherheitsaudits : ein vielsprechendes Instrument zur Förderung der Verkehrssicherheit ?

    NARCIS (Netherlands)

    Wegman, F.C.M. & Schagen, I.N.L.G. van

    1998-01-01

    Das Instrument `Verkehrssicherheitsaudit' (`Audits') hat zum Zweck die infrastrukturellen Bedingungen für Verkehrssicherheit bereits während der Entwurf- und Realisierungsphase der Verkehrsinfrastruktur einzubauen. Dieser Bericht gibt ein Übersicht der Tragweite des Audits. Ausserdem werden

  13. 76 FR 9049 - Notice of Intent To Repatriate Cultural Items: University of Pennsylvania Museum of Archaeology...

    Science.gov (United States)

    2011-02-16

    ... piece, from the root of the red cedar, and is painted with greenish-blue, red, black, and white pigment...). It is a basketry hat, woven of spruce tree roots, which has been painted white. A design representing...

  14. Winter Safety Tips for Older Adults

    Science.gov (United States)

    Winter Safety Tips for Older Adults Expert Information from Healthcare Professionals Who Specialize in the Care of ... thick clothing. Think about getting your thermals! –Essential winter wears: hats, gloves or preferably mittens, winter coat, ...

  15. Nachhaltigkeit und Projektmanagement: Für eine breitere Perspektive auf Projekte

    OpenAIRE

    Martinuzzi, Robert-Andre; Gareis, Roland; Huemann, Martina; Sedlacko, Michal; Ringhofer, Claudia

    2011-01-01

    Im Projektmanagement hat bisher keine substantielle Auseinandersetzung mit den Prinzipien nachhaltiger Entwicklung stattgefunden. Derzeit arbeiten Expert(inn)en aus Nachhaltigkeitsforschung und Projektmanagement gemeinsam an einem konzeptionellen Rahmen, neuen Instrumenten und ersten Fallstudien.

  16. Rezension: Die Kultur des 20. Jahrhunderts im Überblick - von Werner Faulstich (Hg.

    Directory of Open Access Journals (Sweden)

    Raffaela Rogy

    2013-03-01

    Full Text Available Im Sammelband „Die Kultur des 20. Jahrhunderts im Überblick“ geben AutorInnen wie Knut Hickethier einen kultur-, kunst-, sowie mediengeschichtlichen Abriss des vorherigen Jahrhunderts. Die Rezension hat Raffaela Rogy übernommen.

  17. Netzformen und VDE-Bestimmungen

    Science.gov (United States)

    Bernstein, Herbert

    Der Verband Deutscher Elektrotechniker (VDE) hat eine Reihe von Vorschriften ausgearbeitet, die dem Schutz von Leben und Sachen beim Umgang mit elektrischer Energie dienen. Besonders wichtig sind die in den VDE-Bestimmungen 0100 und 0411 festgelegten Vorschriften.

  18. „Aber bitte kein Infotainment!"

    NARCIS (Netherlands)

    Schönbach, K.

    2009-01-01

    Warum sind manche Zeitungen erfolgreich, andere nicht? Seit 13 Jahren befasst sich Klaus Schönbach mit dieser Frage. Mehr als 500 Tageszeitungen hat der Medienforscher untersucht und ist zu erstaunlichen Ergebnissen gekommen.

  19. Dynamical correlation functions of the quadratic coupling spin-Boson model

    Science.gov (United States)

    Zheng, Da-Chuan; Tong, Ning-Hua

    2017-06-01

    The spin-boson model with quadratic coupling is studied using the bosonic numerical renormalization group method. We focus on the dynamical auto-correlation functions {C}O(ω ), with the operator \\hat{O} taken as {\\hat{{{σ }}}}x, {\\hat{{{σ }}}}z, and \\hat{X}, respectively. In the weak-coupling regime α index and X is the boson displacement operator. Close to the spin flip point, the high frequency peak of {C}{{{σ }}x}(ω ) is broadened significantly and the line shape changes qualitatively, showing enhanced dephasing at the spin flip point. Project supported by the National Key Basic Research Program of China (Grant No. 2012CB921704), the National Natural Science Foundation of China (Grant No. 11374362), the Fundamental Research Funds for the Central Universities, China, and the Research Funds of Renmin University of China (Grant No. 15XNLQ03).

  20. Chemotherapy

    Science.gov (United States)

    ... cause nerve problems and burning, numbness, tingling, or shooting pain in the fingers and toes. Certain types ... more comfortable wearing hats, scarves, or wigs to school or other events. Or, you may look great ...

  1. Prevent Injury After a Disaster

    Science.gov (United States)

    ... Preventing Violence Pressure Washer Safety Trench Foot or Immersion Foot Emergency Wound Care Wound Management for Healthcare ... as hard hat, safety glasses, hearing protection, heavy work gloves, and cut-resistant legwear. Avoid contact with ...

  2. Raynaud's Phenomenon

    Science.gov (United States)

    ... Institutes of Health Get Email Updates Contact Us Top Utility Nav Community Outreach Publications in Asian Languages ... several layers of loose clothing, socks, hats, and gloves or mittens. Keep pocket warmers in your pockets ...

  3. Subdural hematoma

    Science.gov (United States)

    ... a head injury. For example, use hard hats, bicycle or motorcycle helmets, and seat belts. Older individuals ... Amit M. Shelat, DO, FACP, Attending Neurologist and Assistant Professor of Clinical Neurology, SUNY Stony Brook, School ...

  4. 76 FR 2955 - Office of the Chief of Protocol; Gifts to Federal Employees from Foreign Government Sources...

    Science.gov (United States)

    2011-01-18

    ... of the S.D.B., Secretary of donor and U.S. fountains of the State, Holy See. Government. Vatican; Bible in a burgundy leather case; book entitled ``Vatican City''; two children's hats; children's puzzle...

  5. Quantitative Zusammensetzung des Gehirns der Mitteleuropäischen Fledermäuse (Rhinolophidae und Vespertilionidae)

    NARCIS (Netherlands)

    Sigmund, Leo; Zajícová, Anna

    1970-01-01

    Die Hirnanalyse der untersuchten Hirnstrukturen von 12 einheimischen Fledermausarten hat gezeigt, dass die Microchiroptera im Hirnbau nicht einheitlich sind. Es lassen sich deutlich die Vertreter der Gattung Myotis, von den Vertretern der Gattung Rhinolophus und Eptesicus unterscheiden. Die Gattung

  6. Race Matters… Still. Rezension zu Tom Angotti und Sylvia Morse (Hg. (2016: Zoned Out! Race, Displacement, and City Planning in New York City. New York City: Terreform.

    Directory of Open Access Journals (Sweden)

    Yuca Meubrink

    2017-06-01

    Full Text Available In ihrem Sammelband Zoned Out! identifizieren Tom Angotti und Sylvia Morse zoning als eines der Planungsinstrumente, welches die historischen Muster ethnischer Diskriminierung und Segregation in New York bis heute immer wieder reproduziert hat. [...

  7. Chaotic inflation in supergravity

    CERN Document Server

    Kawasaki, M

    2001-01-01

    It is shown that chaotic inflation naturally takes place in the framework of supergravity if we assume hat the Kahler potential has a shift symmetry of the inflaton chiral multiplet and introduce a small breaking parameter.

  8. Small molecule inhibitors of histone deacetylases and acetyltransferases as potential therapeutics in oncology

    NARCIS (Netherlands)

    van den Bosch, Thea; Leus, Niek; Timmerman, Tirza; Dekker, Frank J

    2016-01-01

    Uncontrolled cell proliferation and resistance to apoptosis in cancer are, among others, regulated by post-translational modifications of histone proteins. The most investigated type of histone modification is lysine acetylation. Histone acetyltransferases (HATs), acetylate histone lysine residues,

  9. Asymptotic expansion of the wavelet transform with error term

    OpenAIRE

    Pathak, R S; Pathak, Ashish

    2014-01-01

    UsingWong's technique asymptotic expansion for the wavelet transform is derived and thereby asymptotic expansions for Morlet wavelet transform, Mexican Hat wavelet transform and Haar wavelet transform are obtained.

  10. Disease: H01611 [KEGG MEDICUS

    Lifescience Database Archive (English)

    Full Text Available hat includes problems in controlling one's drinking, being preoccupied with alcohol, continuing to use alcoh...g withdrawal symptoms when one rapidly decreases or stops drinking. The contribut

  11. Head Lice: Prevention and Control

    Science.gov (United States)

    ... contact during play and other activities at home, school, and elsewhere (sports activities, playground, slumber parties, camp). Do not share clothing such as hats, scarves, coats, sports uniforms, hair ribbons, or barrettes. Do not share combs, ...

  12. Head Lice: Malathion Frequently Asked Questions

    Science.gov (United States)

    ... contact during play and other activities at home, school, and elsewhere (slumber parties, sports activities, camp, playground). Do not share clothing such as hats, scarves, coats, sports uniforms, hair ribbons, or barrettes. Do not share combs, ...

  13. Retransplantation in Late Hepatic Artery Thrombosis: Graft Access and Transplant Outcome

    Directory of Open Access Journals (Sweden)

    Bettina M. Buchholz, MD, FEBS

    2017-08-01

    Conclusions. Inequity in graft access and peritransplant sepsis are fundamental obstacles for successful re-LT in L-HAT. Offering a graft for those in need at the best window of opportunity could facilitate earlier engrafting with improved outcomes.

  14. More Than Just a Break from Treatment: How Substance Use Disorder Patients Experience the Stable Environment in Horse-Assisted Therapy.

    Science.gov (United States)

    Kern-Godal, Ann; Brenna, Ida Halvorsen; Arnevik, Espen Ajo; Ravndal, Edle

    2016-01-01

    Inclusion of horse-assisted therapy (HAT) in substance use disorder (SUD) treatment is rarely reported. Our previous studies show improved treatment retention and the importance of the patient-horse relationship. This qualitative study used thematic analysis, within a social constructionist framework, to explore how eight patients experienced contextual aspects of HAT's contribution to their SUD treatment. Participants described HAT as a "break from usual treatment". However, four interrelated aspects of this experience, namely "change of focus", "activity", "identity", and "motivation," suggest HAT is more than just a break from usual SUD treatment. The stable environment is portrayed as a context where participants could construct a positive self: one which is useful, responsible, and accepted; more fundamentally, a different self from the "patient/self" receiving treatment for a problem. The implications extend well beyond animal-assisted or other adjunct therapies. Their relevance to broader SUD policy and treatment practices warrants further study.

  15. GPCR Interaction: 106 [GRIPDB[Archive

    Lifescience Database Archive (English)

    Full Text Available hat the oligomerization processes take place early during biosynthesis. Agonists ... homo- and hetero-dimers. In addition, ER fractions include homo- and hetero-dimers. These results suggest t

  16. Pilot Preferences on Vector Moving-Map Displays

    National Research Council Canada - National Science Library

    Lohrenz, Maura C; Myrick, Stephanie A; Trenchard, Michael E; Ruffner, John W; Cohan, Tyrus

    2009-01-01

    ... to a detailed questionnaire concerning the usefulness of each display. This paper summarises aircrew interviews from that study pertaining to both vector moving-map displays and vector feature overlays, including Height-Above-Threshold (HAT...

  17. Diagnostic Accuracy of Molecular Amplification Tests for Human African Trypanosomiasis-Systematic Review

    NARCIS (Netherlands)

    Mugasa, Claire M.; Adams, Emily R.; Boer, Kimberly R.; Dyserinck, Heleen C.; Büscher, Philippe; Schallig, Henk D. H. F.; Leeflang, Mariska M. G.

    2012-01-01

    Background: A range of molecular amplification techniques have been developed for the diagnosis of Human African Trypanosomiasis (HAT); however, careful evaluation of these tests must precede implementation to ensure their high clinical accuracy. Here, we investigated the diagnostic accuracy of

  18. Future treatment options for human African trypanosomiasis.

    Science.gov (United States)

    Jones, Amy J; Avery, Vicky M

    2015-01-01

    Over the past 17 years, the number of reported cases of human African trypanosomiasis (HAT) has declined by over 90%, a significant result since the disease was highlighted as a public health problem by the WHO in 1995. However, if the goal of eliminating HAT by 2020 is to be achieved, then new treatments need to be identified and developed. A plethora of compound collections has been screened against Trypanosoma brucei spp, the etiological agents of HAT, resulting in three compounds progressing to clinical development. However, due to the high attrition rates in drug discovery, it is essential that research continues to identify novel molecules. Failure to do so, will result in the absence of molecules in the pipeline to fall back on should the current clinical trials be unsuccessful. This could seriously compromise control efforts to date, resulting in a resurgence in the number of HAT cases.

  19. The natural progression of Gambiense sleeping sickness: what is the evidence?

    Directory of Open Access Journals (Sweden)

    Francesco Checchi

    Full Text Available Gambiense human African trypanosomiasis (HAT, sleeping sickness is widely assumed to be 100% pathogenic and fatal. However, reports to the contrary exist, and human trypano-tolerance has been postulated. Furthermore, there is uncertainty about the actual duration of both stage 1 and stage 2 infection, particularly with respect to how long a patient remains infectious. Understanding such basic parameters of HAT infection is essential for optimising control strategies based on case detection. We considered the potential existence and relevance of human trypano-tolerance, and explored the duration of infectiousness, through a review of published evidence on the natural progression of gambiense HAT in the absence of treatment, and biological considerations. Published reports indicate that most gambiense HAT cases are fatal if untreated. Self-resolving and asymptomatic chronic infections probably constitute a minority if they do indeed exist. Chronic carriage, however, deserves further study, as it could seed renewed epidemics after control programmes cease.

  20. Comparison of nucleic acid sequence-based amplification and loop-mediated isothermal amplification for diagnosis of human African trypanosomiasis

    NARCIS (Netherlands)

    Mugasa, Claire M.; Katiti, Diana; Boobo, Alex; Lubega, George W.; Schallig, Henk D. F. H.; Matovu, Enock

    2014-01-01

    Diagnosis of human African trypanosomiasis (HAT) using molecular tests should ideally achieve high sensitivity without compromising specificity. This study compared 2 simplified tests, nucleic acid sequence-based amplification (NASBA) combined with oligochromatography (OC) and loop-mediated

  1. Sequence Classification: 889373 [

    Lifescience Database Archive (English)

    Full Text Available hat stimulates the activity of serine palmitoyltransferase (Lcb1p, Lcb2p) several-fold; involved in sphingolipid biosynthesis; Tsc3p || http://www.ncbi.nlm.nih.gov/protein/14270689 ...

  2. Dandruff: How to Treat

    Medline Plus

    Full Text Available ... potential to make your scalp more sensitive to sunlight. If you use this type of dandruff shampoo, it’s important to protect your scalp from the sun by wearing a hat when outdoors and seeking ...

  3. Disease: H01676 [KEGG MEDICUS

    Lifescience Database Archive (English)

    Full Text Available hat cause inflammation of the arachnoid, such as subarachnoid hemorrhage, traumatic brain injury, or menin...gitis. As many as half of patients with NPH have no identifiable risk factor, and i

  4. Pesticide knowledge, practice and attitude and how it affects the ...

    African Journals Online (AJOL)

    2014-06-02

    scale farmers in Uganda: a cross-sectional ... protective equipment (PPE (e.g. mask, boots, gloves, long sleeved shirt, overalls, hat)) ..... What do you wear doing pesticide spraying (PPE)?. Ordinary clothing. 229 (73) 105 (70).

  5. Corporate Social Responsibility. Wider ethische Fehltritte

    OpenAIRE

    Lunau, York

    2001-01-01

    Die Bedeutung von "Corporate Social Responsibility" hat zugenommen. Sie ist ein Garant für einen nachhaltigen Unternehmenserfolg und verhindert, dass bei unternehmensethischen Fehltritten allzu hohe finanzielle Konsequenzen drohen.

  6. Disease: H01626 [KEGG MEDICUS

    Lifescience Database Archive (English)

    Full Text Available nclude age, male gender, smoking, hypertension, hyperlipidemia, diabetes mellitus...hat some micro RNAs could be serum markers for early-stage ASO. Vascular disease ... Cigarette smoking

  7. Rezension: Die Tode in Venedig/Morte a Venezia. Thomas Mann/Luchino Visconti: un confronto von Francesco Bono, Luigi Cimmino und Giorgio Pangaro (Hg.

    Directory of Open Access Journals (Sweden)

    Valerio Furneri

    2014-12-01

    Full Text Available Valerio Furneri rezensiert einen schönen, soeben in Italien erschienenen Band zum 'Tod in Venedig' bei Thomas Mann und Luchino Visconti, der erneut das interessante Forschungsfeld zwischen Kino und Literatur zum Gegenstand hat ...

  8. Human African trypanosomiasis in the Democratic Republic of the Congo: disease distribution and risk.

    Science.gov (United States)

    Lumbala, Crispin; Simarro, Pere P; Cecchi, Giuliano; Paone, Massimo; Franco, José R; Kande Betu Ku Mesu, Victor; Makabuza, Jacquies; Diarra, Abdoulaye; Chansy, Shampa; Priotto, Gerardo; Mattioli, Raffaele C; Jannin, Jean G

    2015-06-06

    For the past three decades, the Democratic Republic of the Congo (DRC) has been the country reporting the highest number of cases of human African trypanosomiasis (HAT). In 2012, DRC continued to bear the heaviest burden of gambiense HAT, accounting for 84 % of all cases reported at the continental level (i.e., 5,968/7,106). This paper reviews the status of sleeping sickness in DRC between 2000 and 2012, with a focus on spatio-temporal patterns. Epidemiological trends at the national and provincial level are presented. The number of HAT cases reported yearly from DRC decreased by 65 % from 2000 to 2012, i.e., from 16,951 to 5,968. At the provincial level a more complex picture emerges. Whilst HAT control in the Equateur province has had a spectacular impact on the number of cases (97 % reduction), the disease has proved more difficult to tackle in other provinces, most notably in Bandundu and Kasai, where, despite substantial progress, HAT remains entrenched. HAT prevalence presents its highest values in the northern part of the Province Orientale, where a number of constraints hinder surveillance and control. Significant coordinated efforts by the National Sleeping Sickness Control Programme and the World Health Organization in data collection, reporting, management and mapping, culminating in the Atlas of HAT, have enabled HAT distribution and risk in DRC to be known with more accuracy than ever before. Over 18,000 locations of epidemiological interest have been geo-referenced (average accuracy ≈ 1.7 km), corresponding to 93.6 % of reported cases (period 2000-2012). The population at risk of contracting sleeping sickness has been calculated for two five-year periods (2003-2007 and 2008-2012), resulting in estimates of 33 and 37 million people respectively. The progressive decrease in HAT cases reported since 2000 in DRC is likely to reflect a real decline in disease incidence. If this result is to be sustained, and if further progress is to be made

  9. Polen vor der Middle-Income-Trap? Entwicklungsplan bis 2030 soll den Aufholprozess beschleunigen

    OpenAIRE

    Holtemöller, Oliver; Kämpfe, Martina

    2017-01-01

    Polen hat seinen Abstand gegenüber den entwickelten Marktwirtschaften Westeuropas seit dem Beginn der 1990er Jahre bis heute gemessen am Pro-Kopf-Einkommen stark verringert. Galt das Land in den ersten zwei Jahrzehnten unter den mittelosteuropäischen Ländern als Vorreiter beim Wirtschaftswachstum, so hat sich das Aufholtempo in den letzten Jahren verlangsamt. Die polnische Regierung reagierte darauf mit einem strategischen Entwicklungsplan ('Morawiecki'-Plan), der Maßnahmen und Ziele bis 2030...

  10. The Search for a Permanent Home: Explaining the Organizational Instability of Air Force Rescue

    Science.gov (United States)

    2015-06-01

    owned the first USAF dedicated rescue force, which was called the Air Rescue Service (ARS) from 1946 to 1966. In 1966 MATS 3 Recovery, an umbrella...standalone rescue force came into existence. Established in March 1946, this force was called the United States’ Air Rescue Service and fell under Air...154. 20 Koskinas, Black Hats and White Hats, 155. 26 the mission area from the Twenty-third Air Force and reactivating the Air Rescue Service on

  11. Socio-economic and cultural determinants of human african trypanosomiasis at the Kenya - Uganda transboundary.

    Directory of Open Access Journals (Sweden)

    Jane Jemeli Rutto

    Full Text Available BACKGROUND: Kenya and Uganda have reported different Human African Trypanosomiasis incidences in the past more than three decades, with the latter recording more cases. This cross-sectional study assessed the demographic characteristics, tsetse and trypanosomiasis control practices, socio-economic and cultural risk factors influencing Trypanosoma brucei rhodesiense (T.b.r. infection in Teso and Busia Districts, Western Kenya and Tororo and Busia Districts, Southeast Uganda. A conceptual framework was postulated to explain interactions of various socio-economic, cultural and tsetse control factors that predispose individuals and populations to HAT. METHODS: A cross-sectional household survey was conducted between April and October 2008. Four administrative districts reporting T.b.r and lying adjacent to each other at the international boundary of Kenya and Uganda were purposely selected. Household data collection was carried out in two villages that had experienced HAT and one other village that had no reported HAT case from 1977 to 2008 in each district. A structured questionnaire was administered to 384 randomly selected household heads or their representatives in each country. The percent of respondents giving a specific answer was reported. Secondary data was also obtained on socio-economic and political issues in both countries. RESULTS: Inadequate knowledge on the disease cycle and intervention measures contributed considerable barriers to HAT, and more so in Uganda than in Kenya. Gender-associated socio-cultural practices greatly predisposed individuals to HAT. Pesticides-based crop husbandry in the 1970's reportedly reduced vector population while vegetation of coffee and banana's and livestock husbandry directly increased occurrence of HAT. Livestock husbandry practices in the villages were strong predictors of HAT incidence. The residents in Kenya (6.7% applied chemoprophylaxis and chemotherapeutic controls against trypanosomiasis to a

  12. China - Nicht alles Gold, was glänzt!

    OpenAIRE

    Kolle, Christian

    2008-01-01

    Anlässlich der XXIX. olympischen Sommerspiele in Peking beschäftigt sich die August-Ausgabe der Recherche Spezial mit den zahlreichen sozialwissenschaftlichen Aspekten und Facetten, die der bevölkerungsreichste Staat der Erde zu bieten hat. Der rasante Aufstieg zur Wirtschaftsmacht innerhalb von nur drei Jahrzehnten hat dem chinesischen Staat zwar internationale Anerkennung gepaart mit ängstlicher Ehrfurcht beschert, ist aber gleichzeitig auch Ursprung einer Reihe von sozialen Problemen i...

  13. Zur Standardisierung der DSH-Prüfungen: Bestandsaufnahme und Perspektiven des Online-Angebotes

    OpenAIRE

    Schneider, Agnieszka

    2010-01-01

    Das Internet ist im 21. Jahrhundert zum wichtigsten Informations- und Kommunikationsmedium geworden und hat auch in der Hochschullandschaft einen festen Platz eingenommen. Das Lernen mit und auf Internetplattformen hat sich im universitären Bereich stark etabliert. Auch die Bedeutung von Online-Prüfungen ist infolge der unter dem Schlagwort "Bologna-Prozess" bekannten Umstrukturierungen stark angestiegen. Da im Bereich der deutschen Sprachprüfung für den Hochschulzugang (DSH) bisher nur wenig...

  14. Eine Entdeckung von ganz außerordentlicher Tragweite Schrödingers Briefwechsel zur Wellenmechanik und zum Katzenparadoxon

    CERN Document Server

    Meyenn, Karl von

    2011-01-01

    Mit der Bekanntgabe seiner Wellenmechanik Anfang des Jahres 1926 eröffnetet Erwin Schrödinger viele neue physikalische Perspektiven. Auch heute noch bildet die Schrödingergleichung die Grundlage der gesamten Mikrophysik und ihrer Anwendungen. Die Entstehungsgeschichte dieser Entdeckung beleuchtet der Band anhand von 300 Briefen, die Schrödinger mit Zeitgenossen, darunter Albert Einstein, ausgetauscht hat. Die Briefe hat der Herausgeber mit Anmerkungen und Kommentaren versehen und in ihren wissenschaftlichen und historischen Kontext gestellt.

  15. Eine ökonomische Analyse der wissensintensiven Dienstleistung Coaching

    OpenAIRE

    Gross, Peter-Paul

    2013-01-01

    Über die letzten 20 Jahre hat sich Coaching zu einer der gefragtesten Personalentwicklungsdienstleistungen entwickelt. Aus dem Sport kommend, wurde Coaching zunächst als exklusive Maßnahme für Top-Führungskräfte konzipiert. In den 1980er Jahren wurden erste Angebote von Top-Executive-Coaching, orientiert an amerikanischen Vorbildern, in Deutschland angeboten. Bis heute hat Coaching darauf einen unglaublichen Boom erlebt. Da ...

  16. A mixed methods study of a health worker training intervention to increase syndromic referral for gambiense human African trypanosomiasis in South Sudan.

    Science.gov (United States)

    Palmer, Jennifer J; Surur, Elizeous I; Checchi, Francesco; Ahmad, Fayaz; Ackom, Franklin Kweku; Whitty, Christopher J M

    2014-03-01

    Active screening by mobile teams is considered the most effective method for detecting gambiense-type human African trypanosomiasis (HAT) but constrained funding in many post-conflict countries limits this approach. Non-specialist health care workers (HCWs) in peripheral health facilities could be trained to identify potential cases for testing based on symptoms. We tested a training intervention for HCWs in peripheral facilities in Nimule, South Sudan to increase knowledge of HAT symptomatology and the rate of syndromic referrals to a central screening and treatment centre. We trained 108 HCWs from 61/74 of the public, private and military peripheral health facilities in the county during six one-day workshops and assessed behaviour change using quantitative and qualitative methods. In four months prior to training, only 2/562 people passively screened for HAT were referred from a peripheral HCW (0 cases detected) compared to 13/352 (2 cases detected) in the four months after, a 6.5-fold increase in the referral rate observed by the hospital. Modest increases in absolute referrals received, however, concealed higher levels of referral activity in the periphery. HCWs in 71.4% of facilities followed-up had made referrals, incorporating new and pre-existing ideas about HAT case detection into referral practice. HCW knowledge scores of HAT symptoms improved across all demographic sub-groups. Of 71 HAT referrals made, two-thirds were from new referrers. Only 11 patients completed the referral, largely because of difficulties patients in remote areas faced accessing transportation. The training increased knowledge and this led to more widespread appropriate HAT referrals from a low base. Many referrals were not completed, however. Increasing access to screening and/or diagnostic tests in the periphery will be needed for greater impact on case-detection in this context. These data suggest it may be possible for peripheral HCWs to target the use of rapid diagnostic tests

  17. Tsetse Control and Gambian Sleeping Sickness; Implications for Control Strategy.

    Directory of Open Access Journals (Sweden)

    Inaki Tirados

    Full Text Available Gambian sleeping sickness (human African trypanosomiasis, HAT outbreaks are brought under control by case detection and treatment although it is recognised that this typically only reaches about 75% of the population. Vector control is capable of completely interrupting HAT transmission but is not used because it is considered too expensive and difficult to organise in resource-poor settings. We conducted a full scale field trial of a refined vector control technology to determine its utility in control of Gambian HAT.The major vector of Gambian HAT is the tsetse fly Glossina fuscipes which lives in the humid zone immediately adjacent to water bodies. From a series of preliminary trials we determined the number of tiny targets required to reduce G. fuscipes populations by more than 90%. Using these data for model calibration we predicted we needed a target density of 20 per linear km of river in riverine savannah to achieve >90% tsetse control. We then carried out a full scale, 500 km2 field trial covering two HAT foci in Northern Uganda to determine the efficacy of tiny targets (overall target density 5.7/km2. In 12 months, tsetse populations declined by more than 90%. As a guide we used a published HAT transmission model and calculated that a 72% reduction in tsetse population is required to stop transmission in those settings.The Ugandan census suggests population density in the HAT foci is approximately 500 per km2. The estimated cost for a single round of active case detection (excluding treatment, covering 80% of the population, is US$433,333 (WHO figures. One year of vector control organised within the country, which can completely stop HAT transmission, would cost US$42,700. The case for adding this method of vector control to case detection and treatment is strong. We outline how such a component could be organised.

  18. Control and surveillance of human African trypanosomiasis.

    Science.gov (United States)

    2013-01-01

    In the 1960s, it appeared that human African trypanosomiasis (HAT) could be effectively controlled, but by the beginning of the twenty-first century several decades of neglect had led to alarming numbers of reported new cases, with an estimated 300 000 people infected. The World Health Organization (WHO) responded with a series of initiatives aimed at bringing HAT under control again. Since 2001, the pharmaceutical companies that produce drugs for HAT have committed themselves to providing them free of charge to WHO for distribution for the treatment of patients. In addition, funds have been provided to WHO to support national sleeping sickness control programmes to boost control and surveillance of the disease. That, coupled with bilateral cooperation and the work of nongovernmental organizations, helped reverse the upward trend in HAT prevalence. By 2012, the number of reported cases was fewer than 8000. This success in bringing HAT under control led to its inclusion in the WHO Roadmap for eradication, elimination and control of neglected tropical diseases, with a target set to eliminate the disease as a public health problem by 2020. A further target has been set, by countries in which HAT is endemic, to eliminate gambiense HAT by reducing the incidence of infection to zero in a defined geographical area. This report provides information about new diagnostic approaches, new therapeutic regimens and better understanding of the distribution of the disease with high-quality mapping. The roles of human and animal reservoirs and the tsetse fly vectors that transmit the parasites are emphasized. The new information has formed the basis for an integrated strategy with which it is hoped that elimination of gambiense HAT will be achieved. The report also contains recommendations on the approaches that will lead to elimination of the disease.

  19. Socio-Economic and Cultural Determinants of Human African Trypanosomiasis at the Kenya – Uganda Transboundary

    Science.gov (United States)

    Rutto, Jane Jemeli; Osano, Odipo; Thuranira, Elias Gitonga; Kurgat, Richard Kiptum; Odenyo, Victor Agab Omondi

    2013-01-01

    Background Kenya and Uganda have reported different Human African Trypanosomiasis incidences in the past more than three decades, with the latter recording more cases. This cross-sectional study assessed the demographic characteristics, tsetse and trypanosomiasis control practices, socio-economic and cultural risk factors influencing Trypanosoma brucei rhodesiense (T.b.r.) infection in Teso and Busia Districts, Western Kenya and Tororo and Busia Districts, Southeast Uganda. A conceptual framework was postulated to explain interactions of various socio-economic, cultural and tsetse control factors that predispose individuals and populations to HAT. Methods A cross-sectional household survey was conducted between April and October 2008. Four administrative districts reporting T.b.r and lying adjacent to each other at the international boundary of Kenya and Uganda were purposely selected. Household data collection was carried out in two villages that had experienced HAT and one other village that had no reported HAT case from 1977 to 2008 in each district. A structured questionnaire was administered to 384 randomly selected household heads or their representatives in each country. The percent of respondents giving a specific answer was reported. Secondary data was also obtained on socio-economic and political issues in both countries. Results Inadequate knowledge on the disease cycle and intervention measures contributed considerable barriers to HAT, and more so in Uganda than in Kenya. Gender-associated socio-cultural practices greatly predisposed individuals to HAT. Pesticides-based crop husbandry in the 1970's reportedly reduced vector population while vegetation of coffee and banana's and livestock husbandry directly increased occurrence of HAT. Livestock husbandry practices in the villages were strong predictors of HAT incidence. The residents in Kenya (6.7%) applied chemoprophylaxis and chemotherapeutic controls against trypanosomiasis to a larger extent than

  20. Experimental and Analytical Studies of the Behavior of Cold-Formed Steel Roof Truss Elements

    OpenAIRE

    Nuttayasakul, Nuthaporn

    2005-01-01

    Cold-formed steel roof truss systems that use complex stiffener patterns in existing hat shape members for both top and bottom chord elements are a growing trend in the North American steel framing industry. When designing cold-formed steel sections, a structural engineer typically tries to improve the local buckling behavior of the cold-formed steel elements. The complex hat shape has proved to limit the negative influence of local buckling, however, distortional buckling can be the contro...

  1. Die transkulturelle Integration außereuropäischer Konzepte in den zweiten deutschen Gesundheitsmarkt, dargestellt am Beispiel Shiatsu Forschungsstand und Endpunktanalyse klinischer Studien zur Wirksamkeit des heterodoxen Verfahrens Shiatsu

    OpenAIRE

    Kleinau, Andrea (Dr.)

    2016-01-01

    Shiatsu, eine japanische Lebensform und ein Behandlungsverfahren der Körperarbeit zugleich, hat auf dem sogenannten zweiten Gesundheitsmarkt in den letzten Jahrzehn-ten in Europa einen festen Platz eingenommen im Zuge einer Integration fremdkultureller Konzepte in die Eigenkultur. Dabei kann in dieser Arbeit belegt werden, dass das Ver-fahren selbst bereits kulturelle Verflechtungen in sich trägt und Anteile anderer Kulturen übernommen hat, so auch der deutschen Lebensform. Eine kontinuierlic...

  2. Einkaufen unter veränderten Vorzeichen: Ausgewählte Erfolgsfaktoren des "Konsortial-Benchmarking Einkauf 2010"

    OpenAIRE

    Kreysa, Jennifer

    2010-01-01

    Die Finanz- und Wirtschaftskrise hat für viele Unternehmen nicht nur das externe Einkaufsumfeld, sondern auch die internen Anforderungen an den Einkauf stark verändert. Für das diesjährige Konsortial-Benchmarking im Einkauf hat die Abteilung Technologiemanagement des Fraunhofer IPT gemeinsam mit einem hochkarätigen Industriekonsortium erneut die Vorgehensweisen und Ansätze besonders erfolgreicher Einkaufsabteilungen analysiert. Die Ergebnisse des Projekts geben nicht nur Aufschluss darüber, w...

  3. Histone acetylation mediates epigenetic regulation of transcriptional reprogramming in insects during metamorphosis, wounding and infection

    Directory of Open Access Journals (Sweden)

    Mukherjee Krishnendu

    2012-10-01

    Full Text Available Abstract Background Gene expression in eukaryotes is regulated by histone acetylation/deacetylation, an epigenetic process mediated by histone acetyltransferases (HATs and histone deacetylases (HDACs whose opposing activities are tightly regulated. The acetylation of histones by HATs increases DNA accessibility and promotes gene expression, whereas the removal of acetyl groups by HDACs has the opposite effect. Results We explored the role of HDACs and HATs in epigenetic reprogramming during metamorphosis, wounding and infection in the lepidopteran model host Galleria mellonella. We measured the expression of genes encoding components of HATs and HDACs to monitor the transcriptional activity of each enzyme complex and found that both enzymes were upregulated during pupation. Specific HAT inhibitors were able to postpone pupation and to reduce insect survival following wounding, whereas HDAC inhibitors accelerated pupation and increased survival. The administration of HDAC inhibitors modulated the expression of effector genes with key roles in tissue remodeling (matrix metalloproteinase, the regulation of sepsis (inhibitor of metalloproteinases from insects and host defense (antimicrobial peptides, and simultaneously induced HAT activity, suggesting that histone acetylation is regulated by a feedback mechanism. We also discovered that both the entomopathogenic fungus Metarhizium anisopliae and the human bacterial pathogen Listeria monocytogenes can delay metamorphosis in G. mellonella by skewing the HDAC/HAT balance. Conclusions Our study provides for the first evidence that pathogenic bacteria can interfere with the regulation of HDACs and HATs in insects which appear to manipulate host immunity and development. We conclude that histone acetylation/deacetylation in insects mediates transcriptional reprogramming during metamorphosis and in response to wounding and infection.

  4. “SALOME gave my dignity back”: The role of randomized heroin trials in transforming lives in the Downtown Eastside of Vancouver, Canada

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    Ehsan Jozaghi

    2014-03-01

    Full Text Available Although numerous studies on heroin-assisted treatment (HAT have been published in leading international journals, little attention has been given to HAT's clients, their stories, and what constitutes the most influential factor in the treatment process. The present study investigates the role of HAT in transforming the lives of injection drug users (IDUs in Vancouver, Canada. This study is qualitative focusing on 16 in-depth interviews with patients from the randomized trials of HAT. Interviews were transcribed verbatim and analyzed thematically using NVivo 10 software. The findings revealed a positive change in many respects: the randomized trials reduce criminal activity, sex work, and illicit drug use. In addition, the trials improved the health and social functioning of its clients, with some participants acquiring work or volunteer positions. Many of the participants have been able to reconnect with their family members, which was not possible before the program. Furthermore, the relationship between the staff and patients at the project appears to have transformed the behavior of participants. Attending HAT in Vancouver has been particularly effective in creating a unique microenvironment where IDUs who have attended HAT have been able to form a collective identity advocating for their rights. The result of this research points to the need for continuation of the project beyond the current study, leading toward a permanent program.

  5. OBLIQUITIES OF HOT JUPITER HOST STARS: EVIDENCE FOR TIDAL INTERACTIONS AND PRIMORDIAL MISALIGNMENTS

    Energy Technology Data Exchange (ETDEWEB)

    Albrecht, Simon; Winn, Joshua N. [Department of Physics, and Kavli Institute for Astrophysics and Space Research, Massachusetts Institute of Technology, Cambridge, MA 02139 (United States); Johnson, John A. [Department of Astrophysics, California Institute of Technology, MC249-17, Pasadena, CA 91125 (United States); Howard, Andrew W.; Marcy, Geoffrey W. [Department of Astronomy, University of California, Berkeley, CA 94720 (United States); Butler, R. Paul [Department of Terrestrial Magnetism, Carnegie Institution of Washington, 5241 Broad Branch Road NW, Washington, DC 20015 (United States); Arriagada, Pamela [Department of Astronomy, Pontificia Universidad Catolica de Chile, Casilla 306, Santiago 22 (Chile); Crane, Jeffrey D.; Shectman, Stephen A.; Thompson, Ian B. [The Observatories of the Carnegie Institution of Washington, 813 Santa Barbara Street, Pasadena, CA 91101 (United States); Hirano, Teruyuki [Department of Physics, University of Tokyo, Tokyo 113-0033 (Japan); Bakos, Gaspar; Hartman, Joel D. [Department of Astrophysical Sciences, Princeton University, Peyton Hall, Princeton, NJ 08544 (United States)

    2012-09-20

    We provide evidence that the obliquities of stars with close-in giant planets were initially nearly random, and that the low obliquities that are often observed are a consequence of star-planet tidal interactions. The evidence is based on 14 new measurements of the Rossiter-McLaughlin effect (for the systems HAT-P-6, HAT-P-7, HAT-P-16, HAT-P-24, HAT-P-32, HAT-P-34, WASP-12, WASP-16, WASP-18, WASP-19, WASP-26, WASP-31, Gl 436, and Kepler-8), as well as a critical review of previous observations. The low-obliquity (well-aligned) systems are those for which the expected tidal timescale is short, and likewise the high-obliquity (misaligned and retrograde) systems are those for which the expected timescale is long. At face value, this finding indicates that the origin of hot Jupiters involves dynamical interactions like planet-planet interactions or the Kozai effect that tilt their orbits rather than inspiraling due to interaction with a protoplanetary disk. We discuss the status of this hypothesis and the observations that are needed for a more definitive conclusion.

  6. OBLIQUITIES OF HOT JUPITER HOST STARS: EVIDENCE FOR TIDAL INTERACTIONS AND PRIMORDIAL MISALIGNMENTS

    International Nuclear Information System (INIS)

    Albrecht, Simon; Winn, Joshua N.; Johnson, John A.; Howard, Andrew W.; Marcy, Geoffrey W.; Butler, R. Paul; Arriagada, Pamela; Crane, Jeffrey D.; Shectman, Stephen A.; Thompson, Ian B.; Hirano, Teruyuki; Bakos, Gaspar; Hartman, Joel D.

    2012-01-01

    We provide evidence that the obliquities of stars with close-in giant planets were initially nearly random, and that the low obliquities that are often observed are a consequence of star-planet tidal interactions. The evidence is based on 14 new measurements of the Rossiter-McLaughlin effect (for the systems HAT-P-6, HAT-P-7, HAT-P-16, HAT-P-24, HAT-P-32, HAT-P-34, WASP-12, WASP-16, WASP-18, WASP-19, WASP-26, WASP-31, Gl 436, and Kepler-8), as well as a critical review of previous observations. The low-obliquity (well-aligned) systems are those for which the expected tidal timescale is short, and likewise the high-obliquity (misaligned and retrograde) systems are those for which the expected timescale is long. At face value, this finding indicates that the origin of hot Jupiters involves dynamical interactions like planet-planet interactions or the Kozai effect that tilt their orbits rather than inspiraling due to interaction with a protoplanetary disk. We discuss the status of this hypothesis and the observations that are needed for a more definitive conclusion.

  7. Ladder Operators for Lamé Spheroconal Harmonic Polynomials

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    Ricardo Méndez-Fragoso

    2012-10-01

    Full Text Available Three sets of ladder operators in spheroconal coordinates and their respective actions on Lamé spheroconal harmonic polynomials are presented in this article. The polynomials are common eigenfunctions of the square of the angular momentum operator and of the asymmetry distribution Hamiltonian for the rotations of asymmetric molecules, in the body-fixed frame with principal axes. The first set of operators for Lamé polynomials of a given species and a fixed value of the square of the angular momentum raise and lower and lower and raise in complementary ways the quantum numbers $n_1$ and $n_2$ counting the respective nodal elliptical cones. The second set of operators consisting of the cartesian components $hat L_x$, $hat L_y$, $hat L_z$ of the angular momentum connect pairs of the four species of polynomials of a chosen kind and angular momentum. The third set of operators, the cartesian components $hat p_x$, $hat p_y$, $hat p_z$ of the linear momentum, connect pairs of the polynomials differing in one unit in their angular momentum and in their parities. Relationships among spheroconal harmonics at the levels of the three sets of operators are illustrated.

  8. Als Clinicus over de Grenzen van de Psychiatrie. De verwantschap tussen literatuur en wetenschap in het werk van de psychiater H.C. Rümke (1893-1967

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    Ingrid Kloosterman

    2010-09-01

    Full Text Available As a clincian beyond the boundaries of psychiatry. The congeniality of literature and psychiatry in the work of psychiatrist H.C. Rümke (1893-1967 One of the most important Dutch psychiatrists in the interwar period was H.C. Rümke (1893-1967. With his eclectic interest in psychiatric approaches such as both psychoanalysis and phenomenology, Rümke is most well known for his remarkable diagnostic and therapeutic skills. The life and work of Rümke has been studied in detail, most notably by the Dutch historian Jacob Van Belzen. Despite this extensive research, in this paper it is stated that a relevant aspect of Rümke’s work has been largely disregarded – namely his profound interest in and use of poetry and literature. Not only did Rümke write poems himself under the pseudonym of H. Cornelius, in his scholarly work he frequently refers to fictional literature and at the end of his career he wrote a comprehensive analysis of Frederik van Eeden’s novel Van de Koele Meeren des Doods. For the eclectic clinician Rümke literature and poetry are a source of knowledge to gain insight into the human psyche. Furthermore, according to Rümke, often literature succeeds better at expressing the human condition than the science of psychiatry can. In this article it is argued that for a coherent interpretation of the life and work of Rümke this literal and poetic aspect of his work cannot be disregarded. It is precisely Rümke’s profound interest in literature and poetry that reflects his two main theses about the science of psychiatry. These are on the one hand the centrality of clinical practice and on the other hand the boundaries of psychiatry. As a clinical practitioner Rümke’s aim was to be able to understand the suffering of the patient – literature and poetry could help him do that. Rümke’s use of literature and poetry can be understood by taking into account the context of the clinic, but the intertwinement between psychiatry

  9. Influence of Pastoralists' Sociocultural Activities on Tsetse-Trypanosome-Cattle Reservoir Interface: The Risk of Human African Trypanosomiasis in North-Central Nigeria.

    Science.gov (United States)

    Alhaji, N B; Kabir, J

    2016-06-01

    The study investigated socio-cultural characteristics of pastoralists that influenced on the tsetse-trypanosome-cattle reservoir interface thereby predisposing them to HAT in Niger State, North-central Nigeria. It was a cross-sectional survey of adult pastoral herders, aged 30 years and above, and conducted between October 2012 and February 2013. A face-to-face structured questionnaire was administered on the pastoralists nested in 96 cattle herds with questions focused on pastoralists' socio-cultural activities and behavioral practices related to HAT risk. Descriptive and analytic statistics were used to describe the obtained data. A total of 384 pastoralists participated, with mean age of 49.6  ± 10.76 SD years. Male respondents constituted 86.7% of gender, while pastoralists of age group 40-49 years constituted 35.4% of respondents. About 59.4% of the pastoralists had knowledge about HAT and its symptoms and only 33.9% of them believed that cattle served as reservoir of HAT trypanosome. Knowledge/belief levels of the pastoralists about African trypanosomiasis occurrence in humans and animals were statistically significant. Males were four times more likely to be exposed to HAT (OR = 3.67; 95% CI: 1.42, 9.52); age group 60-69 was also four times more likely to be exposed (OR = 3.59; 95% CI: 1.56, 8.28); and nomadic pastoralists were two times more likely to be exposed to HAT (OR = 2.07; 95% CI: 1.37, 3.14). All cultural practices significantly influenced exposure to HAT with extensive husbandry system three times more likely to predisposed pastoralists to HAT (OR = 3.21; 95% CI: 1.65, 6.24). Socio-cultural characteristics of pastoralists influenced exposure to HAT risk and, therefore, there is a need to sensitize them to bring changes to their socio-cultural practices and perceptions to achieve effective and long term sustainable HAT control. Elimination strategies of parasites in animals and vectors should be considered to avoid reintroduction

  10. Human Leukocyte Antigen-G: A Promising Prognostic Marker of Disease Progression to Improve the Control of Human African Trypanosomiasis.

    Science.gov (United States)

    Gineau, Laure; Courtin, David; Camara, Mamadou; Ilboudo, Hamidou; Jamonneau, Vincent; Dias, Fabricio C; Tokplonou, Leonidas; Milet, Jacqueline; Mendonça, Priscila B; Castelli, Erick C; Camara, Oumou; Camara, Mariam; Favier, Benoit; Rouas-Freiss, Nathalie; Moreau, Philippe; Donadi, Eduardo A; Bucheton, Bruno; Sabbagh, Audrey; Garcia, André

    2016-11-01

     Human African trypanosomiasis (HAT) caused by Trypanosoma brucei gambiense can be diagnosed in the early hemolymphatic stage (stage 1 [S1]) or meningoencephalitic stage (stage 2 [S2]). Importantly, individuals harbouring high and specific antibody responses to Tbg antigens but negative parasitology are also diagnosed in the field (seropositive [SERO]). Whereas some develop the disease in the months following their initial diagnosis (SERO/HAT), others remain parasitologically negative for long periods (SERO) and are apparently able to control infection. Human leucocyte antigen (HLA)-G, an immunosuppressive molecule, could play a critical role in this variability of progression between infection and disease.  Soluble HLA-G (sHLA-G) was measured in plasma for patients in the SERO (n = 65), SERO/HAT (n = 14), or HAT (n = 268) group and in cerebrospinal fluid for patients in S1 (n = 55), early S2 (n = 93), or late S2 (n = 110). Associations between these different statuses and the soluble level or genetic polymorphisms of HLA-G were explored.  Plasma sHLA-G levels were significantly higher in HAT (P = 6 × 10 -7 ) and SERO/HAT (P = .007) than SERO patients. No difference was observed between the SERO/HAT and HAT groups. Within the HAT group, specific haplotypes (HG010102 and HG0103) displayed increased frequencies in S1 (P = .013) and late S2 (P = .036), respectively.  These results strongly suggest the involvement of HLA-G in HAT disease progression. Importantly, high plasma sHLA-G levels in SERO patients could be predictive of subsequent disease development and could represent a serological marker to help guide therapeutic decision making. Further studies are necessary to assess the predictive nature of HLA-G and to estimate both sensitivity and specificity. © The Author 2016. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail journals.permissions@oup.com.

  11. Impact of mass chemotherapy in domestic livestock for control of zoonotic T. b. rhodesiense human African trypanosomiasis in Eastern Uganda.

    Science.gov (United States)

    Fyfe, Jenna; Picozzi, Kim; Waiswa, Charles; Bardosh, Kevin Louis; Welburn, Susan Christina

    2017-01-01

    Human African trypanosomiasis (HAT) comprises two fatal parasitic diseases. Uganda is home to both chronic T. b. gambiense (gHAT) and the acute zoonotic form T. b. rhodesiense (rHAT) which occur in two large but discrete geographical foci. The area affected by rHAT has been rapidly expanding due to importation of T. b. rhodesiense infected cattle into tsetse infested but previously HAT free districts. Migration of rHAT has resulted in a considerable human health burden in these newly affected districts. Here, we examined the impact of a single, district-wide, mass chemotherapeutic livestock intervention, on T. b. rhodesiense prevalence in cattle and on incidence and distribution of human rHAT cases in Kamuli and Soroti districts in eastern Uganda. A single mass intervention in domestic cattle (n=30,900) using trypanocidal drugs was undertaken in November and December 2002 under the EU funded Farming in Tsetse Controlled Areas (FITCA) programme. The intervention targeted removal of the reservoir of infection i.e. human infective T. b. rhodesiense parasites in cattle, in the absence of tsetse control. Interventions were applied in high-risk sub-counties of Kamuli district (endemic for rHAT) and Soroti district (where rHAT has been recently introduced). The prevalence of T. brucei s.l. and the human infective subspecies, T. b. rhodesiense in cattle (n=1833) was assessed before and 3 and 12 months after intervention using PCR-based methods. A combination of descriptive statistical analysis and spatial scan statistics were applied to analyse rHAT cases reported over a 5-year period (January 2000-July 2005). A single intervention was highly effective at removing human infective T. b. rhodesiense parasites from the cattle reservoir and contributed to a significant decrease in human rHAT cases. Intervention coverage was higher in Kamuli (81.1%) than in Soroti (47.3%) district but despite differences in coverage both districts showed a reduction in prevalence of T. b

  12. Cardiac alterations in human African trypanosomiasis (T.b. gambiense with respect to the disease stage and antiparasitic treatment.

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    Johannes A Blum

    Full Text Available In Human African Trypanosomiasis, neurological symptoms dominate and cardiac involvement has been suggested. Because of increasing resistance to the available drugs for HAT, new compounds are desperately needed. Evaluation of cardiotoxicity is one parameter of drug safety, but without knowledge of the baseline heart involvement in HAT, cardiologic findings and drug-induced alterations will be difficult to interpret. The aims of the study were to assess the frequency and characteristics of electrocardiographic findings in the first stage of HAT, to compare these findings to those of second stage patients and healthy controls and to assess any potential effects of different therapeutic antiparasitic compounds with respect to ECG changes after treatment.Four hundred and six patients with first stage HAT were recruited in the Democratic Republic of Congo, Angola and Sudan between 2002 and 2007 in a series of clinical trials comparing the efficacy and safety of the experimental treatment DB289 to the standard first stage treatment, pentamidine. These ECGs were compared to the ECGs of healthy volunteers (n = 61 and to those of second stage HAT patients (n = 56.In first and second stage HAT, a prolonged QTc interval, repolarization changes and low voltage were significantly more frequent than in healthy controls. Treatment in first stage was associated with repolarization changes in both the DB289 and the pentamidine group to a similar extent. The QTc interval did not change during treatment.Cardiac involvement in HAT, as demonstrated by ECG alterations, appears early in the evolution of the disease. The prolongation of the QTC interval comprises a risk of fatal arrhythmias if new drugs with an additional potential of QTC prolongation will be used. During treatment ECG abnormalities such as repolarization changes consistent with peri-myocarditis occur frequently and appear to be associated with the disease stage, but not with a specific drug.

  13. E2A proteins enhance the histone acetyltransferase activity of the transcriptional co-activators CBP and p300.

    Science.gov (United States)

    Hyndman, Brandy D; Thompson, Patrick; Bayly, Richard; Côté, Graham P; LeBrun, David P

    2012-05-01

    The E2A gene encodes the E-protein transcription factors E12 and E47 that play critical roles in B-lymphopoiesis. A somatic chromosomal translocation detectable in 5% of cases of acute lymphoblastic leukemia (ALL) involves E2A and results in expression of the oncogenic transcription factor E2A-PBX1. CREB binding protein (CBP) and its close paralog p300 are transcriptional co-activators with intrinsic histone acetyltransferase (HAT) activity. We and others have shown that direct binding of an N-terminal transcriptional activation domain present in E12/E47 and E2A-PBX1 to the KIX domain of CBP/p300 contributes to E2A protein function. In the current work we show for the first time that the catalytic HAT activity of CBP/p300 is increased in the presence of residues 1-483 of E2A (i.e., the portion present in E2A-PBX1). The addition of purified, recombinant E2A protein to in vitro assays results in a two-fold augmentation of CBP/p300 HAT activity, whereas in vivo assays show a ten-fold augmentation of HAT-dependent transcriptional induction and a five-fold augmentation of acetylation of reporter plasmid-associated histone by CBP in response to co-transfected E2A. Our results indicate that the HAT-enhancing effect is independent of the well-documented E2A-CBP interaction involving the KIX domain and suggest a role for direct, perhaps low affinity binding of E2A to a portion of CBP that includes the HAT domain and flanking elements. Our findings add to a growing body of literature indicating that interactions between CBP/p300 and transcription factors can function in a specific manner to modulate HAT catalytic activity. Copyright © 2012 Elsevier B.V. All rights reserved.

  14. The socio-economic burden of human African trypanosomiasis and the coping strategies of households in the South Western Kenya foci.

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    Salome A Bukachi

    2017-10-01

    Full Text Available Human African Trypanosomiasis (HAT, a disease caused by protozoan parasites transmitted by tsetse flies, is an important neglected tropical disease endemic in remote regions of sub-Saharan Africa. Although the determination of the burden of HAT has been based on incidence, mortality and morbidity rates, the true burden of HAT goes beyond these metrics. This study sought to establish the socio-economic burden that households with HAT faced and the coping strategies they employed to deal with the increased burden.A mixed methods approach was used and data were obtained through: review of hospital records; structured interviews (152; key informant interviews (11; case narratives (12 and focus group discussions (15 with participants drawn from sleeping sickness patients in the south western HAT foci in Kenya. Quantitative data were analysed using descriptive statistics while qualitative data was analysed based on emerging themes.Socio-economic impacts included, disruption of daily activities, food insecurity, neglect of homestead, poor academic performance/school drop-outs and death. Delayed diagnosis of HAT caused 93% of the affected households to experience an increase in financial expenditure (ranging from US$ 60-170 in seeking treatment. Out of these, 81.5% experienced difficulties in raising money for treatment resorting to various ways of raising it. The coping strategies employed to deal with the increased financial expenditure included: sale of agricultural produce (64%; seeking assistance from family and friends (54%; sale/lease of family assets (22%; seeking credit (22% and use of personal savings (17%.Coping strategies outlined in this study impacted negatively on the affected households leading to further food insecurity and impoverishment. Calculation of the true burden of disease needs to go beyond incidence, mortality and morbidity rates to capture socio-economic variables entailed in seeking treatment and coping strategies of HAT

  15. Novel insect leaf-mining after the end-Cretaceous extinction and the demise of cretaceous leaf miners, Great Plains, USA.

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    Michael P Donovan

    Full Text Available Plant and associated insect-damage diversity in the western U.S.A. decreased significantly at the Cretaceous-Paleogene (K-Pg boundary and remained low until the late Paleocene. However, the Mexican Hat locality (ca. 65 Ma in southeastern Montana, with a typical, low-diversity flora, uniquely exhibits high damage diversity on nearly all its host plants, when compared to all known local and regional early Paleocene sites. The same plant species show minimal damage elsewhere during the early Paleocene. We asked whether the high insect damage diversity at Mexican Hat was more likely related to the survival of Cretaceous insects from refugia or to an influx of novel Paleocene taxa. We compared damage on 1073 leaf fossils from Mexican Hat to over 9000 terminal Cretaceous leaf fossils from the Hell Creek Formation of nearby southwestern North Dakota and to over 9000 Paleocene leaf fossils from the Fort Union Formation in North Dakota, Montana, and Wyoming. We described the entire insect-feeding ichnofauna at Mexican Hat and focused our analysis on leaf mines because they are typically host-specialized and preserve a number of diagnostic morphological characters. Nine mine damage types attributable to three of the four orders of leaf-mining insects are found at Mexican Hat, six of them so far unique to the site. We found no evidence linking any of the diverse Hell Creek mines with those found at Mexican Hat, nor for the survival of any Cretaceous leaf miners over the K-Pg boundary regionally, even on well-sampled, surviving plant families. Overall, our results strongly relate the high damage diversity on the depauperate Mexican Hat flora to an influx of novel insect herbivores during the early Paleocene, possibly caused by a transient warming event and range expansion, and indicate drastic extinction rather than survivorship of Cretaceous insect taxa from refugia.

  16. Novel insect leaf-mining after the end-Cretaceous extinction and the demise of cretaceous leaf miners, Great Plains, USA.

    Science.gov (United States)

    Donovan, Michael P; Wilf, Peter; Labandeira, Conrad C; Johnson, Kirk R; Peppe, Daniel J

    2014-01-01

    Plant and associated insect-damage diversity in the western U.S.A. decreased significantly at the Cretaceous-Paleogene (K-Pg) boundary and remained low until the late Paleocene. However, the Mexican Hat locality (ca. 65 Ma) in southeastern Montana, with a typical, low-diversity flora, uniquely exhibits high damage diversity on nearly all its host plants, when compared to all known local and regional early Paleocene sites. The same plant species show minimal damage elsewhere during the early Paleocene. We asked whether the high insect damage diversity at Mexican Hat was more likely related to the survival of Cretaceous insects from refugia or to an influx of novel Paleocene taxa. We compared damage on 1073 leaf fossils from Mexican Hat to over 9000 terminal Cretaceous leaf fossils from the Hell Creek Formation of nearby southwestern North Dakota and to over 9000 Paleocene leaf fossils from the Fort Union Formation in North Dakota, Montana, and Wyoming. We described the entire insect-feeding ichnofauna at Mexican Hat and focused our analysis on leaf mines because they are typically host-specialized and preserve a number of diagnostic morphological characters. Nine mine damage types attributable to three of the four orders of leaf-mining insects are found at Mexican Hat, six of them so far unique to the site. We found no evidence linking any of the diverse Hell Creek mines with those found at Mexican Hat, nor for the survival of any Cretaceous leaf miners over the K-Pg boundary regionally, even on well-sampled, surviving plant families. Overall, our results strongly relate the high damage diversity on the depauperate Mexican Hat flora to an influx of novel insect herbivores during the early Paleocene, possibly caused by a transient warming event and range expansion, and indicate drastic extinction rather than survivorship of Cretaceous insect taxa from refugia.

  17. The socio-economic burden of human African trypanosomiasis and the coping strategies of households in the South Western Kenya foci.

    Science.gov (United States)

    Bukachi, Salome A; Wandibba, Simiyu; Nyamongo, Isaac K

    2017-10-01

    Human African Trypanosomiasis (HAT), a disease caused by protozoan parasites transmitted by tsetse flies, is an important neglected tropical disease endemic in remote regions of sub-Saharan Africa. Although the determination of the burden of HAT has been based on incidence, mortality and morbidity rates, the true burden of HAT goes beyond these metrics. This study sought to establish the socio-economic burden that households with HAT faced and the coping strategies they employed to deal with the increased burden. A mixed methods approach was used and data were obtained through: review of hospital records; structured interviews (152); key informant interviews (11); case narratives (12) and focus group discussions (15) with participants drawn from sleeping sickness patients in the south western HAT foci in Kenya. Quantitative data were analysed using descriptive statistics while qualitative data was analysed based on emerging themes. Socio-economic impacts included, disruption of daily activities, food insecurity, neglect of homestead, poor academic performance/school drop-outs and death. Delayed diagnosis of HAT caused 93% of the affected households to experience an increase in financial expenditure (ranging from US$ 60-170) in seeking treatment. Out of these, 81.5% experienced difficulties in raising money for treatment resorting to various ways of raising it. The coping strategies employed to deal with the increased financial expenditure included: sale of agricultural produce (64%); seeking assistance from family and friends (54%); sale/lease of family assets (22%); seeking credit (22%) and use of personal savings (17%). Coping strategies outlined in this study impacted negatively on the affected households leading to further food insecurity and impoverishment. Calculation of the true burden of disease needs to go beyond incidence, mortality and morbidity rates to capture socio-economic variables entailed in seeking treatment and coping strategies of HAT affected

  18. Syndromic algorithms for detection of gambiense human African trypanosomiasis in South Sudan.

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    Jennifer J Palmer

    Full Text Available Active screening by mobile teams is considered the best method for detecting human African trypanosomiasis (HAT caused by Trypanosoma brucei gambiense but the current funding context in many post-conflict countries limits this approach. As an alternative, non-specialist health care workers (HCWs in peripheral health facilities could be trained to identify potential cases who need testing based on their symptoms. We explored the predictive value of syndromic referral algorithms to identify symptomatic cases of HAT among a treatment-seeking population in Nimule, South Sudan.Symptom data from 462 patients (27 cases presenting for a HAT test via passive screening over a 7 month period were collected to construct and evaluate over 14,000 four item syndromic algorithms considered simple enough to be used by peripheral HCWs. For comparison, algorithms developed in other settings were also tested on our data, and a panel of expert HAT clinicians were asked to make referral decisions based on the symptom dataset. The best performing algorithms consisted of three core symptoms (sleep problems, neurological problems and weight loss, with or without a history of oedema, cervical adenopathy or proximity to livestock. They had a sensitivity of 88.9-92.6%, a negative predictive value of up to 98.8% and a positive predictive value in this context of 8.4-8.7%. In terms of sensitivity, these out-performed more complex algorithms identified in other studies, as well as the expert panel. The best-performing algorithm is predicted to identify about 9/10 treatment-seeking HAT cases, though only 1/10 patients referred would test positive.In the absence of regular active screening, improving referrals of HAT patients through other means is essential. Systematic use of syndromic algorithms by peripheral HCWs has the potential to increase case detection and would increase their participation in HAT programmes. The algorithms proposed here, though promising, should be

  19. Actigraphy in human African trypanosomiasis as a tool for objective clinical evaluation and monitoring: a pilot study.

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    Alfred K Njamnshi

    Full Text Available Human African trypanosomiasis (HAT or sleeping sickness leads to a complex neuropsychiatric syndrome with characteristic sleep alterations. Current division into a first, hemolymphatic stage and second, meningoencephalitic stage is primarily based on the detection of white blood cells and/or trypanosomes in the cerebrospinal fluid. The validity of this criterion is, however, debated, and novel laboratory biomarkers are under study. Objective clinical HAT evaluation and monitoring is therefore needed. Polysomnography has effectively documented sleep-wake disturbances during HAT, but could be difficult to apply as routine technology in field work. The non-invasive, cost-effective technique of actigraphy has been widely validated as a tool for the ambulatory evaluation of sleep disturbances. In this pilot study, actigraphy was applied to the clinical assessment of HAT patients.Actigraphy was recorded in patients infected by Trypanosoma brucei gambiense, and age- and sex-matched control subjects. Simultaneous nocturnal polysomnography was also performed in the patients. Nine patients, including one child, were analyzed at admission and two of them also during specific treatment. Parameters, analyzed with user-friendly software, included sleep time evaluated from rest-activity signals, rest-activity rhythm waveform and characteristics. The findings showed sleep-wake alterations of various degrees of severity, which in some patients did not parallel white blood cell counts in the cerebrospinal fluid. Actigraphic recording also showed improvement of the analyzed parameters after treatment initiation. Nocturnal polysomnography showed alterations of sleep time closely corresponding to those derived from actigraphy.The data indicate that actigraphy can be an interesting tool for HAT evaluation, providing valuable clinical information through simple technology, well suited also for long-term follow-up. Actigraphy could therefore objectively contribute to

  20. Estimating the economic and social consequences for patients diagnosed with human African trypanosomiasis in Muchinga, Lusaka and Eastern Provinces of Zambia (2004-2014).

    Science.gov (United States)

    Mwiinde, Allan Mayaba; Simuunza, Martin; Namangala, Boniface; Chama-Chiliba, Chitalu Miriam; Machila, Noreen; Anderson, Neil; Shaw, Alexandra; Welburn, Susan C

    2017-10-10

    Acute human African trypanosomiasis (rHAT) caused by Trypanosoma brucei rhodesiense is associated with high mortality and is fatal if left untreated. Only a few studies have examined the psychological, social and economic impacts of rHAT. In this study, mixed qualitative and quantitative research methods were used to evaluate the socio-economic impacts of rHAT in Mambwe, Rufunsa, Mpika and Chama Districts of Zambia. Individuals diagnosed with rHAT from 2004 to 2014 were traced using hospital records and discussions with communities. Either they, or their families, were interviewed using a structured questionnaire and focus group discussions were conducted with affected communities. The burden of the disease was investigated using disability adjusted life years (DALYs), with and without discounting and age-weighting. The impact of long-term disabilities on the rHAT burden was also investigated. Sixty four cases were identified in the study. The majority were identified in second stage, and the mortality rate was high (12.5%). The total number of DALYs was 285 without discounting or age-weighting. When long-term disabilities were included this estimate increased by 50% to 462. The proportion of years lived with disability (YLD) increased from 6.4% to 37% of the undiscounted and un-age-weighted DALY total. When a more active surveillance method was applied in 2013-2014 the cases identified increased dramatically, suggesting a high level of under-reporting. Similarly, the proportion of females increased substantially, indicating that passive surveillance may be especially failing this group. An average of 4.9 months of productive time was lost per patient as a consequence of infection. The health consequences included pain, amnesia and physical disability. The social consequences included stigma, dropping out of education, loss of friends and self-esteem. Results obtained from focus group discussions revealed misconceptions among community members which could be

  1. Towards the Atlas of human African trypanosomiasis

    Directory of Open Access Journals (Sweden)

    Mattioli Raffaele C

    2009-03-01

    Full Text Available Abstract Background Updated, accurate and comprehensive information on the distribution of human African trypanosomiasis (HAT, also known as sleeping sickness, is critically important to plan and monitor control activities. We describe input data, methodology, preliminary results and future prospects of the HAT Atlas initiative, which will allow major improvements in the understanding of the spatial distribution of the disease. Methods Up-to-date as well as historical data collected by national sleeping sickness control programmes, non-governmental organizations and research institutes have been collated over many years by the HAT Control and Surveillance Programme of the World Health Organization. This body of information, unpublished for the most part, is now being screened, harmonized, and analysed by means of database management systems and geographical information systems (GIS. The number of new HAT cases and the number of people screened within a defined geographical entity were chosen as the key variables to map disease distribution in sub-Saharan Africa. Results At the time of writing, over 600 epidemiological reports and files from seventeen countries were collated and included in the data repository. The reports contain information on approximately 20,000 HAT cases, associated to over 7,000 different geographical entities. The oldest epidemiological records considered so far date back to 1985, the most recent having been gathered in 2008. Data from Cameroon, Central African Republic, Chad, Congo, Equatorial Guinea and Gabon from the year 2000 onwards were fully processed and the preliminary regional map of HAT distribution is presented. Conclusion The use of GIS tools and geo-referenced, village-level epidemiological data allow the production of maps that substantially improve on the spatial quality of previous cartographic products of similar scope. The significant differences between our preliminary outputs and earlier maps of HAT

  2. Transfection using hydroxyapatite nanoparticles in the inner ear via an intact round window membrane in chinchilla

    Energy Technology Data Exchange (ETDEWEB)

    Wu Xuewen; Ding Dalian [Central South University, Department of Otolaryngology Head and Neck Surgery, The Third Xiangya Hospital (China); Jiang Haiyan [State University of New York at Buffalo, Center for Hearing and Deafness (United States); XingXiaowei [Central South University, Department of Otolaryngology Head and Neck Surgery, The Third Xiangya Hospital (China); Huang, Suping [Central South University, State Key Laboratory of Powder Metallurgy (China); Liu Hong [Central South University, Department of Otolaryngology Head and Neck Surgery, The Third Xiangya Hospital (China); Chen Zhedong [Central South University, State Key Laboratory of Powder Metallurgy (China); Sun Hong, E-mail: shjhaj@vip.163.com [Central South University, Department of Otolaryngology Head and Neck Surgery, Xiangya Hospital (China)

    2012-01-15

    Hydroxyapatite nanoparticles (nHAT) are known to have excellent biocompatibility, and have attracted increasing attention as new candidates of non-viral vectors for gene therapy. In our previous studies, nHAT carrying a therapeutic gene and a reporter gene were successfully transfected into the spiral ganglion neurons in the inner ear of guinea pigs in vivo as well as in the cultured cell lines, although the transfection efficiencies were never higher than 30%. In this study, the surface modification of nHAT with polyethylenimine (PEI) was made (PEI-nHAT, diameter = 73.09 {+-} 27.32 nm) and a recombinant plasmid carrying enhanced green fluorescent protein (EGFP) gene and neurotrophin-3 (NT-3) gene was constructed as pEGFPC2-NT3. The PEI modified nHAT and the recombinant plasmid was then connected to form the nHAT-based vector-gene complex (PEI-nHAT-pEGFPC2-NT3). This complex was then placed onto the intact round window membranes of the chinchillas for inner ear transfection. Auditory brainstem response (ABR) was tested to evaluate auditory function. Green fluorescence of EGFP was observed using confocal microscopy 48 h after administering vector-gene complexes. There was no significant threshold shift in tone burst-evoked ABR at any tested frequency. Abundant, condensed green fluorescence was found in dark cells on both sides of the crista and around the macula of the utricle. Scattered EGFP signals were also detected in vestibular hair cells, some Schwann cells in the cochlear spiral ganglion region, some outer pillar cells in the organ of Corti, and a few cells in the stria vascularis. The density of green fluorescence-marked cells was obviously higher in the vestibular dark cell area than in other areas of the inner ear, suggesting that vestibular dark cells may have the ability to actively engulf the nHAT-based vector-gene complexes. Considering the high transfection efficiency in the vestibular system, PEI-nHAT may be a potential vector for gene therapy of

  3. The changing epidemiology of human African trypanosomiasis among patients from nonendemic countries--1902-2012.

    Directory of Open Access Journals (Sweden)

    Ami Neuberger

    Full Text Available BACKGROUND: Although human African trypanosomiasis (HAT is uncommon among patients from non-endemic countries (NEC, there has been an increase in the number of cases reported in recent years. METHODS: A systematic review of the literature was performed. The number of incoming tourists to HAT endemic countries was obtained from the United Nations World Tourism Organization. All HAT cases diagnosed in patients from NEC were included. Immigrants and refugees were excluded. We compared patients during and after the colonial period, and analyzed the relationship between the number of incoming travellers and the number of HAT cases. RESULTS: Between 1902 and 2012, HAT was reported in 244 patients. Most HAT cases were reported before 1920, and after the year 2000. In the colonial era the average age of patients was lower (32.5±7.8 vs. 43.0±16.1 years, P<0.001, the proportion of females was lower (10.0% vs. 23.9%, P<0.01], most cases were diagnosed in expatriates, missionaries and soldiers (74.3%, and Gambian trypanosomiasis accounted for 86/110, (78% of cases. In the post-colonial era most patients 91/125 (72.8% were short-term tourists to game parks in Eastern and South-Eastern Africa (mainly in Tanzania; Rhodesian trypanosomiasis accounted for 94/123 (76.4% of cases. Between 1995 and 2010 there has been a constant linear increase in the number of incoming tourists to Tanzania, and HAT cases occurred in small outbreaks rather than following a similar linear pattern. CONCLUSIONS: In recent decades HAT patients from NEC are older, and more likely to be tourists who acquired the disease while visiting game-parks in Eastern and South-Eastern Africa. While Rhodesian trypanosomiasis is relatively uncommon among Africans, it now accounts for most cases reported among patients from NEC. Returning febrile travellers without an alternative diagnosis should be evaluated for HAT. Cases among travellers may serve as sentinels for Rhodesian trypanosomiasis "hot

  4. Mapping the capacities of fixed health facilities to cover people at risk of gambiense human African trypanosomiasis.

    Science.gov (United States)

    Simarro, Pere P; Cecchi, Giuliano; Franco, José R; Paone, Massimo; Diarra, Abdoulaye; Ruiz-Postigo, José A; Mattioli, Raffaele C; Jannin, Jean G

    2014-02-11

    The emphasis placed on the activities of mobile teams in the detection of gambiense human African trypanosomiasis (HAT) can at times obscure the major role played by fixed health facilities in HAT control and surveillance. The lack of consistent and detailed data on the coverage of passive case-finding and treatment further constrains our ability to appreciate the full contribution of the health system to the control of HAT. A survey was made of all fixed health facilities that are active in the control and surveillance of gambiense HAT. Information on their diagnostic and treatment capabilities was collected, reviewed and harmonized. Health facilities were geo-referenced. Time-cost distance analysis was conducted to estimate physical accessibility and the potential coverage of the population at-risk of gambiense HAT. Information provided by the National Sleeping Sickness Control Programmes revealed the existence of 632 fixed health facilities that are active in the control and surveillance of gambiense HAT in endemic countries having reported cases or having conducted active screening activities during the period 2000-2012. Different types of diagnosis (clinical, serological, parasitological and disease staging) are available from 622 facilities. Treatment with pentamidine for first-stage disease is provided by 495 health facilities, while for second-stage disease various types of treatment are available in 206 health facilities only. Over 80% of the population at-risk for gambiense HAT lives within 5-hour travel of a fixed health facility offering diagnosis and treatment for the disease. Fixed health facilities have played a crucial role in the diagnosis, treatment and coverage of at-risk-population for gambiense HAT. As the number of reported cases continues to dwindle, their role will become increasingly important for the prospects of disease elimination. Future updates of the database here presented will regularly provide evidence to inform and monitor a

  5. Acetylation of Mammalian ADA3 Is Required for Its Functional Roles in Histone Acetylation and Cell Proliferation.

    Science.gov (United States)

    Mohibi, Shakur; Srivastava, Shashank; Bele, Aditya; Mirza, Sameer; Band, Hamid; Band, Vimla

    2016-10-01

    Alteration/deficiency in activation 3 (ADA3) is an essential component of specific histone acetyltransferase (HAT) complexes. We have previously shown that ADA3 is required for establishing global histone acetylation patterns and for normal cell cycle progression (S. Mohibi et al., J Biol Chem 287:29442-29456, 2012, http://dx.doi.org/10.1074/jbc.M112.378901). Here, we report that these functional roles of ADA3 require its acetylation. We show that ADA3 acetylation, which is dynamically regulated in a cell cycle-dependent manner, reflects a balance of coordinated actions of its associated HATs, GCN5, PCAF, and p300, and a new partner that we define, the deacetylase SIRT1. We use mass spectrometry and site-directed mutagenesis to identify major sites of ADA3 acetylated by GCN5 and p300. Acetylation-defective mutants are capable of interacting with HATs and other components of HAT complexes but are deficient in their ability to restore ADA3-dependent global or locus-specific histone acetylation marks and cell proliferation in Ada3-deleted murine embryonic fibroblasts (MEFs). Given the key importance of ADA3-containing HAT complexes in the regulation of various biological processes, including the cell cycle, our study presents a novel mechanism to regulate the function of these complexes through dynamic ADA3 acetylation. Copyright © 2016, American Society for Microbiology. All Rights Reserved.

  6. Assessment of health awareness and its sources among journalism and mass communication students at yarmouk university, jordan.

    Science.gov (United States)

    El-Qaderi, S S

    1997-01-01

    This study assesses the overall health awareness level of students of the Department of Journalism and Mass Communication at Yarmouk University/Jordan who are supposed to have an important leadership role among mass media professionals in Jordan. A Health Awareness Test (HAT) was administered to a random sample of 139 students of this group (52.85% of the target population). Findings revealed that their overall average performance on the HAT was significantly much lower than the acceptable criterion score determined by the HAT authors. Female students' performance on the HAT was significantly higher than males' performance. The academic level of these students (2nd, 3rd or 4th academic year) did not have significant influence on their scores. Furthermore, the two-way ANOVA analysis showed that there was no significant difference in the achievement of the study subjects on the HAT by sex and academic level. The major sources of the health awareness information of these students ranked by order were: mass media, self-education, academic preparation (information included in the curricula), family and peers, and finally cultural events in the form of extra-curricular activities at the University. Recommendations based upon these results are given.

  7. Alpha-tocopherol transfer factor (aTTF) from rat liver mediates the transfer of d-alpha-(/sup 3/H)-tocopherol from liposomes to human erythrocyte ghosts and exhibits saturation kinetics

    Energy Technology Data Exchange (ETDEWEB)

    Verdon, C.P.; Blumberg, J.B.

    1986-01-01

    aTTF was observed to transfer d-alpha-(/sup 3/H)-tocopherol (/sup 3/HaT) from egg lecithin liposomes to human erythrocyte ghosts (EG). aTTF may be associated with the 32,000-35,000 MW alpha-Tocopherol Binding Protein previously described to transfer /sup 3/HaT from liposomes to rat liver microsomes and mitochondria prepared by ammonium sulfate precipitation of rat liver cytosol followed by dialysis against 50 mM TRIS-HCl/1 mM EDTA buffer, pH 7.4. Assay for aTTF activity consisted of incubating liposomal /sup 3/HaT and EG in the presence of aTTF or buffer blank for various time periods at 37/sup 0/C, then counting the resulting radioactivity in washed EG after pelleting by centrifugation. Liposomes were prelabeled-with non-exchangable glycerol-(/sup 14/C)-trioleate to correct for liposomes adhering to pelleted EG. Greater than 50% of the tritium found with the EG pellet was recovered by HPLC as /sup 3/HaT. aTTF activity increased with increasing liposomal /sup 3/HaT concentration before reaching a plateau. aTTF activity was similarly saturated by increasing EG concentrations. The same assay conditions with buffer blank along resulted in negligible transfer activity.

  8. Investigating the potential of a novel low-energy house concept with hybrid adaptable thermal storage

    International Nuclear Information System (INIS)

    Hoes, P.; Trcka, M.; Hensen, J.L.M.; Hoekstra Bonnema, B.

    2011-01-01

    Research highlights: → In conventional buildings thermal mass is a permanent building characteristic. → Permanent thermal mass concepts are not optimal in all operational conditions. → We propose a concept that combines the benefits of low and high thermal mass. → Building simulation shows the concept is able to reduce the energy demand with 35%. → Furthermore, the concept increases the performance robustness of the building. -- Abstract: In conventional buildings thermal mass is a permanent building characteristic depending on the building design. However, none of the permanent thermal mass concepts are optimal in all operational conditions. We propose a concept that combines the benefits of buildings with low and high thermal mass by applying hybrid adaptable thermal storage (HATS) systems and materials to a lightweight building. The HATS concept increases building performance and the robustness to changing user behavior, seasonal variations and future climate changes. Building performance simulation is used to investigate the potential of the novel concept for reducing heating energy demand and increasing thermal comfort. Simulation results of a case study in the Netherlands show that the optimal quantity of the thermal mass is sensitive to the change of seasons. This implies that the building performance will benefit from implementing HATS. Furthermore, the potential of HATS is quantified using a simplified HATS model. Calculations show heating energy demand reductions of up to 35% and increased thermal comfort compared to conventional thermal mass concepts.

  9. The challenging problem of disease staging in human African trypanosomiasis (sleeping sickness): a new approach to a circular question.

    Science.gov (United States)

    Njamnshi, Alfred K; Gettinby, George; Kennedy, Peter G E

    2017-05-01

    Human African trypanosomiasis (HAT), also known as sleeping sickness, puts millions of people at risk in sub-Saharan Africa and is a neglected parasitic disease that is almost always fatal if untreated or inadequately treated. HAT manifests itself in two stages that are difficult to distinguish clinically. The problem of staging in HAT is extremely important since treatment options, some of which are highly toxic, are directly linked to the disease stage. Several suggested investigations for disease staging have been problematic because of the lack of an existing gold standard with which to compare new clinical staging markers. The somewhat arbitrary current criteria based on the cerebrospinal fluid (CSF) white blood cell (WBC) count have been widely used, but the new potential biomarkers are generally compared with these, thereby making the problem somewhat circular in nature. We propose an alternative 'reverse' approach to address this problem, conceptualised as using appropriate statistical methods to test the performance of combinations of established laboratory variables as staging biomarkers to correlate with the CSF WBC/trypanosomes and clinical features of HAT. This approach could lead to the use of established laboratory staging markers, potentially leading to a gold standard for staging and clinical follow-up of HAT. © The Author 2017. Published by Oxford University Press on behalf of Royal Society of Tropical Medicine and Hygiene. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

  10. A nanoparticle-based epigenetic modulator for efficient gene modulation

    Science.gov (United States)

    Pongkulapa, Thanapat

    Modulation of gene expression through chromatin remodeling involves epigenetic mechanisms, such as histone acetylation. Acetylation is tightly regulated by two classes of enzymes, histone acetyltransferases (HATs) and histone deacetylases (HDACs). Molecules that can regulate these enzymes by altering (activating or inhibiting) their functions have become a valuable tool for understanding cell development and diseases. HAT activators, i.e. N-(4-Chloro-(3-trifluoromethyl)phenyl)-2-ethoxybenzamide (CTB), have shown a therapeutic potential for many diseases, including cancer and neurodegeneration. However, these compounds encounter a solubility and a membrane permeability issue, which restricts their full potential for practical usage, especially for in vivo applications. To address this issue, in this work, we developed a nanoparticle-based HAT activator CTB, named Au-CTB, by incorporating a new CTB analogue onto gold nanoparticles (AuNPs) along with a poly(ethylene glycol) moiety and a nuclear localization signal (NLS) peptide to assist with solubility and membrane permeability. We found that our new CTB analogue and Au-CTB could activate HAT activity. Significantly, an increase in potency to activate HAT activity by Au-CTB proved the effectiveness of using the nanoparticle delivery platform. In addition, the versatility of Au-CTB platform permits the attachment of multiple ligands with tunable ratios on the nanoparticle surface via facile surface functionalization of gold nanoparticles. Due to its high delivery efficiency and versatility, Au-CTB can be a powerful platform for applications in epigenetic regulation of gene expression.

  11. Emotion recognition through static faces and moving bodies: a comparison between typically-developed adults and individuals with high level of autistic traits

    Directory of Open Access Journals (Sweden)

    Rossana eActis-Grosso

    2015-10-01

    Full Text Available We investigated whether the type of stimulus (pictures of static faces vs. body motion contributes differently to the recognition of emotions. The performance (accuracy and response times of 25 Low Autistic Traits (LAT group young adults (21 males and 20 young adults (16 males with either High Autistic Traits (HAT group or with High Functioning Autism Spectrum Disorder was compared in the recognition of four emotions (Happiness, Anger, Fear and Sadness either shown in static faces or conveyed by moving bodies (patch-light displays, PLDs. Overall, HAT individuals were as accurate as LAT ones in perceiving emotions both with faces and with PLDs. Moreover, they correctly described non-emotional actions depicted by PLDs, indicating that they perceived the motion conveyed by the PLDs per se. For LAT participants, happiness proved to be the easiest emotion to be recognized: in line with previous studies we found a happy face advantage for faces, which for the first time was also found for bodies (happy body advantage. Furthermore, LAT participants recognized sadness better by static faces and fear by PLDs. This advantage for motion kinematics in the recognition of fear was not present in HAT participants, suggesting that i emotion recognition is not generally impaired in HAT individuals, ii the cues exploited for emotion recognition by LAT and HAT groups are not always the same. These findings are discussed against the background of emotional processing in typically and atypically developed individuals.

  12. Emotion recognition through static faces and moving bodies: a comparison between typically developed adults and individuals with high level of autistic traits.

    Science.gov (United States)

    Actis-Grosso, Rossana; Bossi, Francesco; Ricciardelli, Paola

    2015-01-01

    We investigated whether the type of stimulus (pictures of static faces vs. body motion) contributes differently to the recognition of emotions. The performance (accuracy and response times) of 25 Low Autistic Traits (LAT group) young adults (21 males) and 20 young adults (16 males) with either High Autistic Traits or with High Functioning Autism Spectrum Disorder (HAT group) was compared in the recognition of four emotions (Happiness, Anger, Fear, and Sadness) either shown in static faces or conveyed by moving body patch-light displays (PLDs). Overall, HAT individuals were as accurate as LAT ones in perceiving emotions both with faces and with PLDs. Moreover, they correctly described non-emotional actions depicted by PLDs, indicating that they perceived the motion conveyed by the PLDs per se. For LAT participants, happiness proved to be the easiest emotion to be recognized: in line with previous studies we found a happy face advantage for faces, which for the first time was also found for bodies (happy body advantage). Furthermore, LAT participants recognized sadness better by static faces and fear by PLDs. This advantage for motion kinematics in the recognition of fear was not present in HAT participants, suggesting that (i) emotion recognition is not generally impaired in HAT individuals, (ii) the cues exploited for emotion recognition by LAT and HAT groups are not always the same. These findings are discussed against the background of emotional processing in typically and atypically developed individuals.

  13. Influence of different seasons during late gestation on Holstein cows' colostrum and postnatal adaptive capability of their calves

    Science.gov (United States)

    Trifković, Julijana; Jovanović, Ljubomir; Đurić, Miloje; Stevanović-Đorđević, Snežana; Milanović, Svetlana; Lazarević, Miodrag; Sladojević, Željko; Kirovski, Danijela

    2018-02-01

    Season may affect calves' thermal comfort and behavior, but the data related to the overall influence of seasonal variations on dams' colostrum and postnatal adaptive capability of calves are limited. The aim of this study was to measure the effects of a 49-day-long low air temperature (LAT) season (5.20 ± 0.46 °C mean air temperature) and a 53-day-long high air temperature (HAT) season (27.40 ± 0.39 °C mean air temperature) on dams' colostrum quality and physiological, biochemical, hormonal, and oxidative stress parameters of their calves during the first 7 days of life. The dams' colostrum was sampled at 2, 14, and 26 h after calving, before feeding of their calves. Calves' blood samples were taken before the first colostrum intake and on days 1, 2, 3, and 7 of life. Calves' physiological parameters were measured on days 0 and 7. HAT season significantly reduced the quality of dams' colostrum. The ingestion of the low-quality colostrum, combined with the thermal discomfort during HAT season, probably provoked impaired physiological, biochemical, hormonal, and oxidative stress parameters in samples taken from the post-colostral calves. Additionally, intravenous glucose tolerance test was performed on day 7, which suggested an enhanced insulin response in HAT season calves. This study highlights the importance of adequate supporting strategies for the care of the late gestation cows and postnatal calves during the HAT season.

  14. Delivery of antihuman African trypanosomiasis drugs across the blood-brain and blood-CSF barriers.

    Science.gov (United States)

    Sekhar, Gayathri N; Watson, Christopher P; Fidanboylu, Mehmet; Sanderson, Lisa; Thomas, Sarah A

    2014-01-01

    Human African trypanosomiasis (HAT or sleeping sickness) is a potentially fatal disease caused by the parasite, Trypanosoma brucei sp. The parasites are transmitted by the bite of insect vectors belonging to the genus Glossina (tsetse flies) and display a life cycle strategy that is equally spread between human and insect hosts. T.b. gambiense is found in western and central Africa whereas, T.b. rhodesiense is found in eastern and southern Africa. The disease has two clinical stages: a blood stage after the bite of an infected tsetse fly, followed by a central nervous system (CNS) stage where the parasite penetrates the brain; causing death if left untreated. The blood-brain barrier (BBB) makes the CNS stage difficult to treat because it prevents 98% of all known compounds from entering the brain, including some anti-HAT drugs. Those that do enter the brain are toxic compounds in their own right and have serious side effects. There are only a few drugs available to treat HAT and those that do are stage specific. This review summarizes the incidence, diagnosis, and treatment of HAT and provides a close examination of the BBB transport of anti-HAT drugs and an overview of the latest drugs in development. © 2014 Elsevier Inc. All rights reserved.

  15. A Brief Review of Drug Discovery Research for Human African Trypanosomiasis.

    Science.gov (United States)

    Cullen, Danica R; Mocerino, Mauro

    2017-01-01

    Human African Trypanosomiasis (HAT), a neglected disease endemic in Sub- Saharan Africa, is usually fatal if left untreated. It is caused by the parasite Trypanosoma brucei, and is spread by the tsetse fly. The drugs currently available to treat HAT are few, and limited in efficacy. Furthermore, resistance towards these drugs is beginning to grow. In the last 25 years, only one advance has been made into HAT treatment and consequently, there is an increasing need for new drugs to be sought that are able to effectively treat this disease. This review provides a brief overview of drug discovery research for HAT, focusing on research published in the last four years, identifying new molecules with the potential to be developed into anti-HAT agents. The methods of drug discovery have been grouped into three key areas; new molecules inspired by known antitrypanosomal agents, target-based screening, and phenotypic screening. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.org.

  16. A targeted door-to-door strategy for sleeping sickness detection in low-prevalence settings in Côte d’Ivoire

    Directory of Open Access Journals (Sweden)

    Koffi Mathurin

    2016-01-01

    Full Text Available Significant efforts to control human African trypanosomiasis (HAT over the three past decades have resulted in drastic reductions of disease prevalence in Côte d’Ivoire. In this context, the costly and labor-intensive active mass screening strategy is no longer efficient. In addition to a more cost-effective passive surveillance system being implemented in this low-prevalence context, our aim was to develop an alternative targeted active screening strategy. In 2012, we carried out a targeted door-to-door (TDD survey focused on the immediate vicinities of former HAT patients detected in the HAT focus of Bonon and compared the results to those obtained during classical active mass screening (AMS surveys conducted from 2000 to 2012 in the same area. The TDD that provides a friendlier environment, inviting inhabitants to participate and gain awareness of the disease, detected significantly more HAT cases than the AMS. These results suggest that the TDD is an efficient and useful strategy in low-prevalence settings where very localized transmission cycles may persist and, in combination with passive surveillance, could help in eliminating HAT.

  17. Assessment of the burden of human African trypanosomiasis by rapid participatory appraisal in three high-risk villages in Urambo District, Northwest Tanzania.

    Science.gov (United States)

    Reid, H; Kibona, S; Rodney, A; McPherson, B; Sindato, C; Malele, I; Kinung'hi, S; Jennaway, M; Changalucha, J; Blake, B; Vallely, A

    2012-06-01

    The public health and socio-economic burden of Human African Trypanosomiasis (HAT) in East Africa is not well documented. Understanding the epidemiology and impact of HAT in such settings is difficult due to a lack of robust surveillance and reporting systems, restricting evidence-based policy development and contributing to the continued neglect of this disease. To investigate the burden of HAT in Urambo District, Tanzania in order to inform future public health policy. A rapid participatory appraisal (RPA) using a combination of qualitative and quantitative methods was conducted, that included key informant interviews, hospital record analysis, and tools adapted from participatory learning and action. Three villages adjacent to Ugala Game Reserve appeared to be the most affected. High levels of under-reporting were noted due to a lack of diagnostic tools at peripheral health care facilities and limited access to specialist services. Community stakeholders perceived the health and socio-economic burden of HAT to be similar to that of malaria. The burden of HAT in remote rural communities is difficult to capture through routine surveillance systems alone. The RPA represents an efficient mechanism for engaging communities in public health action for trypanosomiasis control in northwest Tanzania.

  18. Kynurenine Pathway Activation in Human African Trypanosomiasis.

    Science.gov (United States)

    Sternberg, Jeremy M; Forrest, Caroline M; Dalton, R Neil; Turner, Charles; Rodgers, Jean; Stone, Trevor W; Kennedy, Peter G E

    2017-03-01

    The kynurenine pathway of tryptophan oxidation is associated with central nervous system (CNS) inflammatory pathways. Inhibition of this pathway ameliorates CNS inflammation in rodent models of the late (meningoencephalitic) stage of human African trypanosomiasis (HAT). In this study, we evaluate whether the kynurenine pathway is activated in clinical HAT and associated with CNS inflammatory responses. We measured cerebrospinal fluid (CSF) tryptophan and kynurenine metabolite concentrations in patients infected with Trypanosoma brucei rhodesiense, using liquid chromatography-mass spectrometry. Kynurenine concentration in CSF was increased in both the early and late stages of disease, with a progressive increase in tryptophan oxidation associated with stage progression. Kynurenine pathway activation was associated with increases in neuroinflammatory markers, but there was no clear relationship to neurological symptoms. CNS kynurenine pathway activation occurs during HAT, including cases prior to the current diagnostic cutoff for late-stage infection, providing evidence for early CNS involvement in HAT. Metabolite data demonstrate that the kynurenine-3-monooxygenase and kynurenine aminotransferase branches of the kynurenine pathway are active. The association between tryptophan oxidation and CNS inflammatory responses as measured by CSF interleukin 6 (IL-6) concentration supports a role of kynurenine metabolites in the inflammatory pathogenesis of late-stage HAT. © The Author 2016. Published by Oxford University Press for the Infectious Diseases Society of America.

  19. Design and Parametric Sizing of Deep Space Habitats Supporting NASA'S Human Space Flight Architecture Team

    Science.gov (United States)

    Toups, Larry; Simon, Matthew; Smitherman, David; Spexarth, Gary

    2012-01-01

    NASA's Human Space Flight Architecture Team (HAT) is a multi-disciplinary, cross-agency study team that conducts strategic analysis of integrated development approaches for human and robotic space exploration architectures. During each analysis cycle, HAT iterates and refines the definition of design reference missions (DRMs), which inform the definition of a set of integrated capabilities required to explore multiple destinations. An important capability identified in this capability-driven approach is habitation, which is necessary for crewmembers to live and work effectively during long duration transits to and operations at exploration destinations beyond Low Earth Orbit (LEO). This capability is captured by an element referred to as the Deep Space Habitat (DSH), which provides all equipment and resources for the functions required to support crew safety, health, and work including: life support, food preparation, waste management, sleep quarters, and housekeeping.The purpose of this paper is to describe the design of the DSH capable of supporting crew during exploration missions. First, the paper describes the functionality required in a DSH to support the HAT defined exploration missions, the parameters affecting its design, and the assumptions used in the sizing of the habitat. Then, the process used for arriving at parametric sizing estimates to support additional HAT analyses is detailed. Finally, results from the HAT Cycle C DSH sizing are presented followed by a brief description of the remaining design trades and technological advancements necessary to enable the exploration habitation capability.

  20. IL-6 is Upregulated in Late-Stage Disease in Monkeys Experimentally Infected with Trypanosoma brucei rhodesiense

    Directory of Open Access Journals (Sweden)

    Dawn Nyawira Maranga

    2013-01-01

    Full Text Available The management of human African trypanosomiasis (HAT is constrained by lack of simple-to-use diagnostic, staging, and treatment tools. The search for novel biomarkers is, therefore, essential in the fight against HAT. The current study aimed at investigating the potential of IL-6 as an adjunct parameter for HAT stage determination in vervet monkey model. Four adult vervet monkeys (Chlorocebus aethiops were experimentally infected with Trypanosoma brucei rhodesiense and treated subcuratively at 28 days after infection (dpi to induce late stage disease. Three noninfected monkeys formed the control group. Cerebrospinal fluid (CSF and blood samples were obtained at weekly intervals and assessed for various biological parameters. A typical HAT-like infection was observed. The late stage was characterized by significant (P<0.05 elevation of CSF IL-6, white blood cell count, and total protein starting 35 dpi with peak levels of these parameters coinciding with relapse parasitaemia. Brain immunohistochemical staining revealed an increase in brain glial fibrillary acidic protein expression indicative of reactive astrogliosis in infected animals which were euthanized in late-stage disease. The elevation of IL-6 in CSF which accompanied other HAT biomarkers indicates onset of parasite neuroinvasion and show potential for use as an adjunct late-stage disease biomarker in the Rhodesian sleeping sickness.