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Sample records for meditsinskogo izotopa 99mtc

  1. Thyroidal radioisotope uptake in euthyroid cats : a comparison between 131I and 99MTcO4

    Directory of Open Access Journals (Sweden)

    N. Lambrechts

    1997-07-01

    Full Text Available Two thyroidal evaluation systems in euthyroid cats (n = 12 were compared. A single, confirmed hyperthyroid cat was included for interest. Firstly, thyroidal uptake of an intravenous bolus of approximately 111 MBq (3 mCi 99MTcO4- was estimated by using a scintillation camera and calculating the ratio of thyroid to salivary activities at 20 min and 4 h. Thyroid to salivary activity ratios were 1:1 at 20 min and 2:1 at 4 h. Two discrete areas of salivary uptake were identified, namely a parotid/mandibular complex and a more rostral buccal/sublingual complex. These results were compared to radioiodine uptake of an oral dose of approximately 0.925 MBq (25 mCi 131I using a standard thyroid uptake system, measured at 1, 2, 4, 6, 8, 10, 12, 24 and 48 h after administration. Mean radioiodine thyroidal uptake started at 33 % at 1 h, stabilised at 21 % between 4 and 24 h, and dropped to 18 % at 48 h. There was a significant correlation between the early thyroid:salivary ratio of the parotid/mandibular complex and the radioiodine uptake at 12 h.

  2. Labelled Preformed liposomes with 99MTC-DTPA, 99 MTC-ECD, 99MTC-MDP and 99MTC-MIBI : Labelling procedures and stability studies

    International Nuclear Information System (INIS)

    Savio, E.O.; Teran, M.A.; Vales, M.E.; Frier, M.

    2004-01-01

    Liposomes labelled with gamma e miters like 99mTc, can be used for scintigraphic imaging to non-invasively track and quantify the distribution of liposomes in the body. In vitro studies were done to choose a suitable radiopharmaceutical (RF) to be attached to performed liposomes. 99mTc-Complexes (DTPA, ECD, MDP, MIBI) were used to label collagen liposomes. Commercial kits were labelled with 99mTc04-(TechnoNuclear). Quality controls of the RF were performed. Collagen liposomes suspended in saline 0.9% were incubated at 4.25.37 and 60 for 30 min. Efficiency of the labelling procedure was determined by gel filtration using Sephadex G25 (Pharmacia) and NaC10.9%. Samples of 100mL (74MBq), were seeded and fractions of 0.5mL were colleted and measured in an ionisation chamber (Capintec CRC). Stability of the labelled liposomes was assessed incubating 0.5mL, of the suspension with 1mL of human serum during 30 min at 37 . Dialysis was performed using dialysis bags of 64 K pore size and NaCI 0.9% at room temperature. Samples of the saline bath were collected at 30.60 and 90 min. and measured in a solid scintillation counter Ortec.Liposomes labelled with 99mTc-DTPA and 99mTcMIBI showed a labelling efficiency of 80%; liposomes incubated with 99mTc-MDP were labelled in a 50% and 99mTc-ECD did not bind to liposomes in the conditions of study. Incubation of labelled liposomes with human serum showed 50% of strong binding to the plasmatic proteins for 99mTc-DTPA but low values (5%) for the other specimens. Labelled liposomes were achieved, with different RF, showing a suitable in vitro stability to perform in vivo studies

  3. Calculated activities of some isotopes in the RA reactor highly enriched fuel significant for possible environmental contamination - Operational report; Radni izvestaj - Proracun aktivnosti nekih izotopa u visokoobogacenom uranskom gorivu reaktora RA, znacajnih sa gledista moguce kontaminacije okoline

    Energy Technology Data Exchange (ETDEWEB)

    Bulovic, V; Martinc, R; Cupac, S [Institute of Nuclear Sciences Boris Kidric, Vinca, Beograd (Serbia and Montenegro)

    1976-12-15

    This report contains calculation basis and obtained results of activities for three groups of isotopes in the RA reactor 80% enriched fuel element. The following isotopes are included: 1) {sup 85m}Kr, {sup 87}Kr, {sup 88}Kr, {sup 131}J, {sup 132}J, {sup 133}J, {sup 134}J, {sup 135}J, {sup 133}Xe, {sup 138}Xe i {sup 138}Cs, 2) {sup 89}Sr, {sup 90}Sr, {sup 91}Sr, {sup 92}Sr, {sup 95}Zr, {sup 97}Zr, {sup 103}Ru, {sup 105}Ru, {sup 106}Ru, {sup 129m}Te, {sup 134}Cs, {sup 137}Cs, {sup 140}Ba, {sup 144}Ce, kao i 3) {sup 238}Pu, {sup 239}Pu i {sup 240}Pu. It was estimated that the fuel is exposed to mean neutron flux. The periodicity of reactor operation is taken into account. Calculation results are given dependent on the time of exposure. These results are to be used as source data for Ra reactor safety analyses. [Serbo-Croat] Izlozene su osnove i prikazani su rezultati izvedenog proracuna aktivnosti tri grupe izotopa u gorivnom elementu reaktora RA sa 80% obogacenim uranom - 235. Obuhvaceni su: 1) {sup 85m}Kr, {sup 87}Kr, {sup 88}Kr, {sup 131}J, {sup 132}J, {sup 133}J, {sup 134}J, {sup 135}J, {sup 133}Xe, {sup 138}Xe i {sup 138}Cs, zatim, 2) {sup 89}Sr, {sup 90}Sr, {sup 91}Sr, {sup 92}Sr, {sup 95}Zr, {sup 97}Zr, {sup 103}Ru, {sup 105}Ru, {sup 106}Ru, {sup 129m}Te, {sup 134}Cs, {sup 137}Cs, {sup 140}Ba, {sup 144}Ce, kao i 3) {sup 238}Pu, {sup 239}Pu i {sup 240}Pu. Pretpostavljeno je da se gorivo ozracuje na srednjem fluksu neutrona, a periodicnost rada reaktora je uvazavana. Rezultati proracuna, dati u numerickom obliku, sistematizovani su kao funkcija toka vremena ozracivanja goriva. Ovi rezultati bice korisceni kao izvorni podaci kod izrade sigurnosnih analiza za reaktor RA (author)

  4. Intraarticular and intravenous administration of 99MTc-HMPAO-labeled human mesenchymal stem cells (99MTC-AH-MSCS): In vivo imaging and biodistribution

    International Nuclear Information System (INIS)

    Meseguer-Olmo, Luis; Montellano, Antonio Jesús; Martínez, Teresa; Martínez, Carlos M.; Revilla-Nuin, Beatriz; Roldán, Marta; Mora, Cristina Fuente; López-Lucas, Maria Dolores; Fuente, Teodomiro

    2017-01-01

    Introduction: Therapeutic application of intravenous administered (IV) human bone marrow-derived mesenchymal stem cells (ahMSCs) appears to have as main drawback the massive retention of cells in the lung parenchyma, questioning the suitability of this via of administration. Intraarticular administration (IAR) could be considered as an alternative route for therapy in degenerative and traumatic joint lesions. Our work is outlined as a comparative study of biodistribution of 99m Tc-ahMSCs after IV and IAR administration, via scintigraphic study in an animal model. Methods: Isolated primary culture of adult human mesenchymal stem cells was labeled with 99m Tc-HMPAO for scintigraphic study of in vivo distribution after intravenous and intra-articular (knee) administration in rabbits. Results: IV administration of radiolabeled ahMSCs showed the bulk of radioactivity in the lung parenchyma while IAR images showed activity mainly in the injected cavity and complete absence of uptake in pulmonary bed. Conclusions: Our study shows that IAR administration overcomes the limitations of IV injection, in particular, those related to cells destruction in the lung parenchyma. After IAR administration, cells remain within the joint cavity, as expected given its size and adhesion properties. Advances in knowledge: Intra-articular administration of adult human mesenchymal stem cells could be a suitable route for therapeutic effect in joint lesions. Implications for patient care: Local administration of adult human mesenchymal stem cells could improve their therapeutic effects, minimizing side effects in patients.

  5. 99MTC Alpha-Fetoprotein: A Novel, Specific Agent for the Detection of Human Breast Cancer

    National Research Council Canada - National Science Library

    Line, Bruce

    1998-01-01

    .... We have demonstrated that technetium-99m radiolabeled human alpha-fetoprotein (99mTc AFP) localizes in human breast cancer cells in-vivo, most likely concentrating in breast cancer cells due to a specific receptor not found in normal adult breast tissue...

  6. 99MTC Alpha-Fetoprotein: A Novel, Specific Agent for the Detection of Human Breast Cancer

    National Research Council Canada - National Science Library

    Line, Bruce

    1999-01-01

    .... We have demonstrated that technetium-99m radiolabeled human alpha-fetoprotein (99mTc AFP) localizes in human breast cancer cells in-vivo, most likely concentrating in breast cancer cells due to a specific receptor not found in normal adult breast tissue...

  7. Radio localization of inflammatory bowel diseases using 99mtc-colloidal bismuth subcitrate

    International Nuclear Information System (INIS)

    Pimentel, G.; Miranda, M.; Sanchez, I.; Oliva, J.; Velasco, M.; Paniagua, M.; Pinol, F.; Riano, A.; Paneque, A.; Castillo, J.; Leyvad, R.

    2006-01-01

    A correct diagnosis and adequate assessment of disease activity is crucial in the management and surveillance of inflammatory bowel diseases (IBDs). However, in certain occasions the obtained results by means of traditional techniques are not correlated specifically with the inflammatory state of the mucosal wall, mainly in case of the small bowel, due to its no accessibility. This investigation constituted a multi centric clinical trial phase I-II. Forty-four patients were prospectively evaluated with the objective of determining the validity of the scintigraphy with 99mTc-Sn-CBS for the diagnosis of illnesses with ulcerations of the intestinal tube. Of the evaluated patients, 20 presented Cohns Disease (in 1 of them the scintigraphy was not useful), Idiopathic Ulcerative Colitis, 3 gastric ulcer and 20 patients were seemingly healthy, conforming these last ones the group control. Five hundred mgs of CBS were labelled with 370 MBq (10 mCi) of 99mTc and administered by oral via as unique dose. The diagnostic test had duration of three days for each patient: first day for the patient's preparation with soft diet and 20% mannitol and two days for the image registrations. The images were carried out at 2, 4, 6 and 24 hours post administered the product. All procedures were performed by experienced examiners, who were blinded to the clinical data and other results. It was determined the sensibility and specificity of this technique taking like reference test, the colonoscopy, gastroduodenoscopy, intestinal transit and/or biopsy, achieving a sensibility of 91,3% and a specificity of 90%. During the whole study an adverse event appeared, which had not very probable causation according to the scale of Karch and Lasagna. It can be concluded that the diagnostic criteria established in this study can be useful for the evaluation of inflammatory bowel diseases by scintigraphy with 99mTc-Sn-CBS. (Author)

  8. Biodistribution of 99MTc-antimony trisulphide colloid in a species of squamate versus rats

    International Nuclear Information System (INIS)

    Lai, C.; Cooter, R.D.; Tsopelas, C.; Chatterton, B.E.; Munns, S.; Daniels, C.B.

    2003-01-01

    Full text: We were interested in visualising the lymphatic system of dragon lizards, as a prelude to a study investigating regenerating lymphatics in other squamate models. Subcutaneous injection of 99m Tc-antimony trisulphide colloid (AC) intradermally of the tail resulted in rapid migration to the pelvic plexus, with subsequent visualisation of the blood pool and intraabdominal organs. Thirty minutes after intravenous administration of 99m Tc-AC in dragon lizards, there was high blood activity of 7.50% dose/g, liver uptake of 0.27% dose/g, spleen uptake of 0.33% dose/g and femur uptake of 0.03% dose/g. In comparison to a mammalian model of similar size, intravenous injection of this tracer in rats resulted in far lower blood activity of 0.46% dose/g, and substantially higher liver uptake of 9.70% dose/g, spleen uptake of 22.30% dose/g and femur uptake of 1.72% dose/g. These results agree with the British Pharmacopoeial test limits set for the distribution of 99m Tc-AC in mice. In summary, results show the cold blooded lizards to have rapidly migrating lymph in the tail, appearing to enter the circulation near the pelvic plexus. A low metabolic rate of the squamate retained 99m Tc-AC in slowly circulating blood, gradually depositing this colloid in liver and spleen. In contrast, rats have much faster yet typical colloidal uptake by the reticuloendothelial system. Copyright (2003) The Australian and New Zealand Society of Nuclear Medicine Inc

  9. Single vial preparation of 99mtc ciprofloxacin for the detection of extrapulmonary tuberculosis

    International Nuclear Information System (INIS)

    Prasad, Vikas; Singh, B.; Bhattacharya, Anish; Mittal, B.R.; Nidhi; Singh, A.K.; Aggarwal, A.

    2005-01-01

    Full text: Aim: To ascertain the usefulness of single vial formulation of Tc-99m Ciprofloxacin (Diagnobact) in detecting extrapulmonary tuberculosis. Introductions: Tuberculosis is one of the major health concerns not only in developing countries but also in the developed nations. Imaging with radiolabelled broad-spectrum antibiotic, being more specific for infection, has the advantage over other nuclear medicine techniques. We are using Diagnobact to detect sites of infection. Methods: 12 patients (age-23 ±11 years, M:F-8:4) of tuberculosis, confirmed by culture/PCR underwent Diagnobact scan. Scanning was done at 1 hour, 4 hour and 24 hours after intravenous injection of 15 mCi of Diagnobact. Rising lesion to background ratio was taken as the criteria for labeling a Diagnobact scan to be positive.Results: Of the 12 patients, two had tibial tuberculous osteomyelitis (TBOM), two vertebral TBOM, one elbow TBOM, four hip joint TBOM, two shaft of femur TBOM and one patient had soft tissue tuberculosis of gluteal region. Diagnobact scan was positive in 10 patients while two patients with vertebral TBOM were negative. Conclusion: Diagnobact, like Infecton, is also useful for the detection of extra pulmonary tuberculosis but for vertebral TBOM. However, more patients need to be studied to reach at statistically significant conclusion. (author)

  10. The antibiotic peptide 99'MTc-alafosfalin detects inflamed bowel in rats

    International Nuclear Information System (INIS)

    Tsopelas, C.; Bartholomeusz, D.; Penglis, S.; Ruszkiewicz, A.

    2002-01-01

    Full text: Radiolabelled leucocyte scans are established as an accurate method of detecting inflammatory bowel disease and focal infection but involve complex in vitro cell labelling techniques. As antibiotic peptides accumulate at sites of inflammation, we studied the localisation of the antibiotic dipeptide 99m Tc-alafosfalin in a rat model of colitis and compared it to the non-specific marker 99m Tc-DTPA. Distal colitis was induced in female Sprague-Dawley rats (175g) 4 days following the rectal infusion of 1 ml trinitrobenzylsulphonic acid (80mg/ml; 30% aq. ethanol). Six colitic and 6 control rats were each injected intravenously with 5MBq 99m Tc-alafosfalin (>90% radiolabelling efficiency) and 5MBq 99m Tc-DTPA and organ and target site uptake measured by scintigraphy and quantitative counting of excised tissue (% injected dose/gram tissue) at 1 and 4 hours. Colitis was confirmed by histological examination of rectal specimens. The scans and tissue counts showed significant focal accumulation of 99m Tc-alafosfalin in inflamed rectum compared to normal bowel (p 99m Tc-alafosfalin compared to 99m Tc-DTPA (p=0.03). Copyright (2002) The Australian and New Zealand Society of Nuclear Medicine Inc

  11. Development and evaluation of a novel (99mtc-labeled annexin A5 for early detection of response to chemotherapy.

    Directory of Open Access Journals (Sweden)

    Kazuma Ogawa

    Full Text Available (99mTc-HYNIC-annexin A5 can be considered as a benchmark in the field of apoptosis imaging. However, (99mTc-HYNIC-annexin A5 has characteristics of high uptake and long retention in non-target tissues such as kidney and liver. To minimize this problem, we developed a novel (99mTc-labeled annexin A5 using a bis(hydroxamamide derivative [C3(BHam2] as a bifunctional chelating agent, and evaluated its usefulness as an imaging agent for detecting apoptosis. The amino group of C3(BHam2 was converted to a maleimide group, and was coupled to thiol groups of annexin A5 pretreated with 2-iminothiolane. (99mTc labeling was performed by a ligand exchange reaction with (99mTc-glucoheptonate. Biodistribution experiments for both (99mTc-C3(BHam2-annexin A5 and (99mTc-HYNIC-annexin A5 were performed in normal mice. In addition, in tumor-bearing mice, the relationship between the therapeutic effects of chemotherapy (5-FU and the tumor accumulation of (99mTc-C3(BHam2-annexin A5 just after the first treatment of 5-FU was evaluated. (99mTc-C3(BHam2-annexin A5 was prepared with a radiochemical purity of over 95%. In biodistribution experiments, (99mTc-C3(BHam2-annexin A5 had a much lower kidney accumulation of radioactivity than (99mTc-HYNIC-annexin A5. In the organs for metabolism, such as liver and kidney, radioactivity after the injection of (99mTc-HYNIC-annexin A5 was residual for a long time. On the other hand, radioactivity after the injection of (99mTc-C3(BHam2-annexin A5 gradually decreased. In therapeutic experiments, tumor growth in the mice treated with 5-FU was significantly inhibited. Accumulation of (99mTc-C3(BHam2-annexin A5 in tumors significantly increased after 5-FU treatment. The accumulation of radioactivity in tumor correlated positively with the counts of TUNEL-positive cells. These findings suggest that (99mTc-C3(BHam2-annexin A5 may contribute to the efficient detection of apoptotic tumor response after chemotherapy.

  12. Differential diagnosis of MRI detected intra cranial space occupying lesions (ICSOLS)-role of 99MTC tetrofosmin cerebral spect

    International Nuclear Information System (INIS)

    Padmal, S.; Sundaram, P.S.; Kumar, S.

    2004-01-01

    Discriminating the correct etiology of Intra Cranial Space Occupying Lesions (ICSOLs) detected by MRI is of paramount importance in deciding the right therapeutic approach. Functional imaging like 99m Tc Tetrofosmin cerebral SPECT (C SPECT) can be used to differentiate malignant from other benign cerebral pathologies. Objective: Our aim was to assess the efficacy of C SPECT in differentiating various etiologies (i.e. Infective / Inflammatory, Neoplastic and Post Radiotherapy changes) of MRI detected ICSOLs. We also aimed to assess the incremental value of quantitative uptake ratios in identifying the exact nature of ICSOLs. Method: 26 Patients (M:F=20:6), age range 28-76 yrs, mean 42±7 yrs were evaluated by 99mTc Tetrofosmin cerebral SPECT. 14/26 patients were HIV positive cases while remaining 12 were treated patients of intracerebral malignancies. All these patients had one or more discrete MRI detected ICSOLs. 6/4 patients with HIV and 4/12 patients in the non HIV group showed more than 1 discrete ICSOLs. 20 mci of 99mTc Tetrofosmin was injected IV .15 min (early) and 2 hrs (delayed) post injection C SPECT images were acquired on a dual head variable angle Gamma camera. After reconstruction, transverse, coronal and sagittal images were co- registered with DICOM online available MRI images using aco- registration software. Focal Tetrofosmin uptake in MRI detected ICSOL was interpreted as abnormal. Tetrofosmin uptake index (Ix) was calculated in early and delayed images as ratio of counts in lesion to that of contra lateral region. A value of more than 1.3 was considered to be abnormal. Persistent Ix of more than 1.3 in initial and delayed images were considered to be malignant while Ix of more or less than 1.3 in initial but less than 1.3 in delayed images was considered to be benign in both groups. Results: In HIV group (14 pts), 4 patients showed an Ix of less than 1.3 in both early and delayed images and 7 patients showed an Ix of more than 1.3 in early but

  13. 99MTc - DMSA renal scintigraphy in the diagnosis and follow-up of acute pyelonephritis in children

    International Nuclear Information System (INIS)

    Wallin, L.

    1997-06-01

    The aim of the present thesis was to define and evaluate a strategy for identification of children who are at risk of developing progressive renal lesions after acute pyelonephritis. Qualitative and quantitative evaluation standards were elaborated to improve the interpretation of DMSA scintigraphy. The normal DMSA distribution pattern, the average background uptake, and scintigraphic kidney length according to age were assessed in 95 presumably healthy kidneys. Furthermore, typical DMSA distribution patterns in acute pyelonephritis were assessed on 65 kidneys in 38 children, and typical DMSA distribution patterns of 152 kidneys with VUR in 101 children with and without previous pyelonephritis. Measurement of scintigraphic kidney length, width and volume was validated in piglets and on a kidney phantom. The scintigraphic kidney length was found to be an accurate measure of renal size, whereas kidney width and volume were less reliable, at least on small kidneys. Criteria of kidney swelling in acute pyelonephritis were defined, and found to be beneficial for identifying reinfections in the absence of clinical symptoms. In 34 children with acute pyelonephritis quantitative and qualitative DMSA scintigraphic findings were correlated to clinical symptoms and laboratory data, in the acute stage and at follow up. We found that quantitative DMSA scintigraphy in the acute stage of pyelonephritis and again after one year will identify children who are at risk of developing progressive renal lesions. Qualitative assessment of DMSA distribution pattern is not reliable enough in this respect. 116 refs., 7 figs

  14. Scintigraphy with 99MTC-MIBI in the assessment and the prediction of multidrug resistance in patients with lymphoma

    International Nuclear Information System (INIS)

    Peña Quian, Yamilé; Perera Pintado, Alejandro; Batista Cuellar, Juan F.; Prats Capote, Anaís; Coca Pérez, Marco A.; Sánchez González, Yolaine; Quesada Pozo, Rodobaldo; Hernández Ramírez, Porfirio; Silva Marín, Caridad; Morales Pérez, Ernesto; Peña Coego, Andria; Toirac Garcías, Noresma

    2007-01-01

    To determine the utility of scintigraphy with 99m Tc-MIBI for non-invasively assessment and prediction of multidrug resistance in patients with lymphoma. 152 patients were evaluated (120 with lymphoma and 32 with benign diseases of the lymph nodes). The biopsy of lymph nodes constituted the gold standard. Static images of thorax, abdomen and pelvis were acquired at 20 min, 2h, 3h and 4h after the intravenous administration of 925-1110 MBq (20-30 mCi) of 99m Tc-MIBI. The uptake indexes were determined for each time and the index of maximum uptake (ICmax) of the radiopharmaceutical for all patients was also calculated. The index of maximum uptake was compared with the clinical and hematological response to chemotherapy. The studies with 99m Tc-MIBI showed values of sensibility, specificity and diagnostic accuracy of 96%, 75% and 92%, respectively. Once chemotherapeutic treatment was concluded, 48 of the 120 studied patients with lymphoma showed complete remission of the disease, meanwhile 32 of them showed partial remission and non response to chemotherapy was observed in 40 cases. The outcomes of the present work revealed that a high index of maximum uptake (ICmax ≥6) could be an indicator of good response to chemotherapy, values of ICmax in a range from 3 to 6 were associated to either complete or partial remission and a ICmax ≤3 could be an indicator of poor response to chemotherapy. The scintigraphy with 99m Tc-MIBI was a useful tool for the study of patients with lymphoma and the assessment of their response to chemotherapy. (author)

  15. 99MTC-HL91 spect image versus 18F-FDG PET for detection of head and neck carcinoma

    International Nuclear Information System (INIS)

    Chu, L.S.; Liu, R.S.; Chou, K.L.; Yang, B.H.; Liao, S.Q.; Yeh, S.H.

    2004-01-01

    Objective: Tumor hypoxia is a major complication of oncologic cell switch for chemotherapy(C/T) and / or radiotherapy(R/T). Such lesions detected by selective modem conventional examination remains difficult. 99mTc-HL91 is a potential agent for imaging hypoxic tissue in vivo. This study aimed to assess efficacy of 99mTc- HL91 in imaging of head and neck cancer and compared the result with 18F-fluorodeoxyglucose(FDG)PET. Methods: Sixteen pts with head and neck cancers (7 hypopharyngeal cancers, 4 laryngeal cancers, 5 tongue base cancers) were enrolled in this study. Primary tumors and suspicious local,regional metastases were diagnosed by clinical examination, CT/MRI , and biopsy. After intravenous injection of 740 MBq of 99mTc-HL91, whole body planar scan and regional SPECT at 2hr postinjection were performed. Tumor lesion -to- normal background(T/N) ratios with 3x3 pixels of background ROI were also measured. The reference range of T/N ratio greater 3.0 defined +, close to 2.4 defined +/- and less than 1.5 defined as -. The FDG images with dedicated PET system was performed at 4hr after completion of 99mTc-HL91 study. The visualized tumors uptake with ratio of standardized uptake value (SUV) greater than 2.5 defined as +.. less than 2.5 defined -. Results: In 7 hypopharyngeal cancers, there are 2FDG+/HL91+, 3FDG+/HL91-, 2FDG+/HL91+/-, In 4 laryngeal cancers, there are 3FDG+/HL91-, 1FDG+/HL91 +/-. In 5 tongue base cancers, there are 5FDG+/HL91-.(Table 1). The T/N ratios of all head and neck cancers in primary tumor and regional lymph nodes were ranged from l.3/1.5 and 1.1/1.2 respectively. The frequency of FDG + in hypopharyngeal cancers is 1.0,in laryngeal cancers is 1.0 and in tongue base cancers is 1.0. The frequency of HL91+/+/- in hypopharyngeal cancers is 0..58,in laryngeal cancers is 0.25.and in tongue base cancers is 0. The overall detection rate of head and neck cancer by FDG+ in this study is 100% and overall detection rate of local-regional hypoxia, by

  16. Dual-Phase 99MTc-MIBI Parathyroid Imaging Reveals Synchronous Parathyroid Adenoma and Papillary Thyroid Carcinoma: A Case Report

    Directory of Open Access Journals (Sweden)

    Ming-Che Chang

    2008-10-01

    Full Text Available The possibility of a coincidental appearance of hyperparathyroidism and thyroid cancer is not often considered because of its low incidence. Here, we present a case of a 49-year-old woman with a parathyroid adenoma coexisting with two sites of papillary thyroid carcinoma. Dual-phase 99mTc-methoxyisobutylisonitrile (MIBI parathyroid imaging before the operation correctly visualized the site of the parathyroid adenoma. In addition, two papillary thyroid carcinomas showed faint uptake of 99mTc-MIBI on delayed image. Total thyroidectomy and parathyroidectomy of a solitary parathyroid adenoma were performed. The patient subsequently underwent radioiodine-131 ablation and was treated with T4 suppression. This case illustrates the need for clinical awareness of concomitant hyperparathyroidism and thyroid cancer. Dual-phase 99mTc-MIBI parathyroid imaging may be useful for detecting indolent thyroid cancer before it becomes a distinct disease.

  17. Role of adenosine 99MTc sestamibi myocardial perfusion spect in evaluation of symptomatic hypertensives with recent onset left bundle branch block

    International Nuclear Information System (INIS)

    Padma, S.; Sundaram, P.S.; Zachariah, M.; Hariads, K.K.

    2004-01-01

    septal reversible perfusion defect had CAD. Interestingly all but one pt with isolated fixed septal defect had no significant stenosis angiographically. Specificity and negative predictive value (86% and 93%) were high only when septal and other reversible defects were considered. Conclusion: We conclude that 99mTc MIBI AMPI should be the imaging modality of choice in the evaluation of IHD in symptomatic hypertensive pts with LBBB. There is a high negative predictive value for IHD in our series.Our study also highlights those patients showing Septal reversible perfusion defect with or without associated reversible defects in AMPI definitely need to undergo Coronary angiogram while pts with isolated fixed septal defect need not be subjected for the same. (authors)

  18. Preparation of N-(3-BROMO-2,4,6-trimethylacetanilide) iminodiacetic acid and its 99MTc-complex for hepatobiliary imaging

    International Nuclear Information System (INIS)

    Choi, Ok Ja; Hong, Young Don; Gwon, Hui Jeong; Choi, Sang Mu; Choi, Sun Ju

    2005-01-01

    N-(3-bromo-2,4,6-trimethylacetanilide) iminodiacetic acid (BrTIDA) was synthesized using nitrilotriacetic anhydride prepared in situ, and lyophilized vials were prepared which contained 20 mg of BrTIDA and 0.4 mg of SnCl 2 . To evaluate the clinical efficacy of the in-house prepared lyophilized kit, a technetium-99m complex of BrTIDA was prepared; its in vivo pharmacokinetic behavior was evaluated via animal studies to assess the hepatocytic function and the functional status of the cystic duct and the gallbladder. Serial static image scans of rabbits and the biodistribution in mice injected with 99m Tc-BrTIDA revealed that none of the tissues except for the hepatobiliary system showed radioactivity concentrations, and a rapid clearance from the organs was observed. In conclusion, a lyophilized kit and its prepared 99m Tc-BrTIDA can be applied as a hepatobiliary imaging agent for the evaluation of the functional status of the hepatocytes and the patency of the biliary duct

  19. The prognostic value of 99MTc-MIBI stress-rest myocardial perfusion imaging in patients suspected with coronary artery disease

    International Nuclear Information System (INIS)

    Wu Zhifang; Li Sijin; Liu Jianzhong; Zhang Wanchun

    2004-01-01

    Objective: To evaluate the prognostic value of 99mTc-MIBI stress-rest myocardial perfusion imaging (MPI) for patients suspected with coronary artery disease (CAD). Methods: 206 consecutive patients suspected with CAD (165 males, 41 females; age range 16-90 years, mean age 55.94±12.46 years) underwent 99mTc-MIBI stress-rest myocardial perfusion imaging (two days protocol), 57 pts with hypertension, 68 pts with hyperlipemia, 39 pts with diabetes and 62 pts with the family history of CAD. According to the imaging results, the 206 patients were divided into 3 groups. G1, normal, 135 pts; G2, reversible defects, 20 pts; G3, fixed defects, 51 pts. The mean time of follow-up was 33.25±14.95 (1-56) months. Results: The rate of cardiac events (CE) occurrence of the three groups was 1.5% (2/135), 65% ( 13/20) and 7.8% (4/51) respectively and there was significant difference between them. Kaplan-Meier survival curves analyzing the no-CE rates in the three groups, ischemic patients demonstrated a more significantly lower than normal and infarction ones in the no-CE rates(Log-rank statistic, chi-square 124.89, P <0.0001). The better predictor of future cardiac events is the reversible defect. Over all, 23.9% of the patients with abnormal stress MPI occurred cardiac events, but only 7.5% of the patients with abnormal rest ones did(chi-square 5.80, P =0.016). The prognoses of patients with normal stress MPI result were better than those with normal rest ones (1.5% versus 9.7%, chi-square 8.94, P =0.0028). Compared with rest MPI, the stress one is a better predictable method to analyze the patient' s condition and evaluate the prognosis. Conclusions: 99mTc-MIBI stress-rest myocardial perfusion imaging is a better Methods to evaluate the prognosis of patients suspected with CAD, and the rate of CE occurrence was 65% in reversible defects patients in this study. (authors)

  20. The development of a highly specific radiochemical compound based on labeled 99mtc recombinant molecules for targeted imaging of cells with the overexpression of Her-2 / neu

    Directory of Open Access Journals (Sweden)

    Olga D. Bragina

    2017-01-01

    Full Text Available Currently, there is a urgent need to search for new diagnostic methods that allow us to reveal malignant tumors with the overexpression of Her-2/neu with high accuracy. In recent years radioisotope methods have been actively developing to identify specific tumor targets, with antibodies being the “targeting” module.The purpose of the study. Creation of a chemically stable radiochemical compound for the imaging of cells with the overexpression of Her-2/neu.Materials and methods. The study was conducted using two human adenocarcinoma cell lines with expression (BT-474 and without expression (MCF-7 Her-2/neu. The specificity of the binding of the test complex with Her-2/neu receptor was determined by direct radiometric and planar scintigraphy. To evaluate the differences in quantitative characteristics between the groups a non-parametric Mann – Whitney test was used.Results. The yield of the labeled complex was more than 91% and the radiochemical frequency was more than 94%. When performing a visual scintigraphic evaluation, a much higher accumulation rate of the studied radiopharmaceutical preparation (RFP was observed in the culture of cells with overexpression of the surface Her-2/neu receptor. Direct radiometric results also demonstrated a higher accumulation of RFPs in the human BT-474 mammary adenocarcinoma cell line with Her-2/neu overexpression in comparison with the control group.Conclusion. Preclinical studies demonstrated high stability of the test compound, as well as its accumulation in the group of cells with Her-2/neu overexpression

  1. Scatter and cross-talk correction for one-day acquisition of 123I-BMIPP and 99mtc-tetrofosmin myocardial SPECT.

    Science.gov (United States)

    Kaneta, Tomohiro; Kurihara, Hideyuki; Hakamatsuka, Takashi; Ito, Hiroshi; Maruoka, Shin; Fukuda, Hiroshi; Takahashi, Shoki; Yamada, Shogo

    2004-12-01

    123I-15-(p-iodophenyl)-3-(R,S)-methylpentadecanoic acid (BMIPP) and 99mTc-tetrofosmin (TET) are widely used for evaluation of myocardial fatty acid metabolism and perfusion, respectively. ECG-gated TET SPECT is also used for evaluation of myocardial wall motion. These tests are often performed on the same day to minimize both the time required and inconvenience to patients and medical staff. However, as 123I and 99mTc have similar emission energies (159 keV and 140 keV, respectively), it is necessary to consider not only scattered photons, but also primary photons of each radionuclide detected in the wrong window (cross-talk). In this study, we developed and evaluated the effectiveness of a new scatter and cross-talk correction imaging protocol. Fourteen patients with ischemic heart disease or heart failure (8 men and 6 women with a mean age of 69.4 yr, ranging from 45 to 94 yr) were enrolled in this study. In the routine one-day acquisition protocol, BMIPP SPECT was performed in the morning, with TET SPECT performed 4 h later. An additional SPECT was performed just before injection of TET with the energy window for 99mTc. These data correspond to the scatter and cross-talk factor of the next TET SPECT. The correction was performed by subtraction of the scatter and cross-talk factor from TET SPECT. Data are presented as means +/- S.E. Statistical analyses were performed using Wilcoxon's matched-pairs signed-ranks test, and p corrected total count was 26.0 +/- 5.3%. EDV and ESV after correction were significantly greater than those before correction (p = 0.019 and 0.016, respectively). After correction, EF was smaller than that before correction, but the difference was not significant. Perfusion scores (17 segments per heart) were significantly lower after as compared with those before correction (p correction revealed significant differences in EDV, ESV, and perfusion scores. These observations indicate that scatter and cross-talk correction is required for one

  2. Supranormal differential renal function in an obstructed kidney demonstrated on 99MTc-mercaptoacetyltriglycine (MAG3) diuresis renography - is it real or an artifact?

    International Nuclear Information System (INIS)

    Wegner, E.A.; Eagle, B.; Mitchell, G.; Rossleigh, M.A.

    2003-01-01

    Full text: Diuresis renography has been used extensively as a noninvasive method of estimating differential renal function (DRF), which may determine patient management. There has been controversy as to whether the phenomenon of supranormal DRF (>55%) in an obstructed kidney exists and the significance of this finding. A case study of a child with supranormal renal function is presented and the impact of different background regions on DRF calculations is demonstrated. Serial MAG3 studies were performed at ages 3 weeks, 2 and 10 months on a male with an antenatal diagnosis of right hydronephrosis. A weight adjusted dose of MAG3 was given simultaneously with frusemide (1mg/kg). DRF was calculated at 1.5-2.5 minutes following tracer administration. Background correction regions were drawn at the lower pole of each kidney. Supranormal DRF (61%) of the hydronephrotic kidney was demonstrated on the baseline study. There was deterioration in scan appearances and persistent supranormal DRF (64%) on the follow up study and the patient proceeded to pyeloplasty. The post-operative study demonstrated an improvement in scan findings and DRF returned to normal (55%). When suprarenal and perirenal background regions were used, supranormal DFR values were not obtained. Suprarenal background - 47%, 50%, 55% and perirenal background - 55%, 57% and 54% DRF on sequential studies. Review of the literature provides conflicting evidence as to the significance and even existence of this phenomenon. The location of background correction regions appears to influence DRF results. This occurs particularly when MAG3 is used, because of physiological uptake in the liver. Copyright (2003) The Australian and New Zealand Society of Nuclear Medicine Inc

  3. Evaluation of myocardial preconditioning and adenosine effects in cardioprotection in rat hearts with ischemia-reperfusion injury using 99MTc-glucarate imaging

    International Nuclear Information System (INIS)

    Liu Zhonglin; Barrett, H.H.; Koon Yan Pak

    2004-01-01

    Significant tolerance to myocardial ischemia-reperfusion injury, as assessed by biochemical assay and noninvasive infarct-avid imaging, was induced with an IPC protocol in the rat model. The cardioprotection of IPC could be simulated by adenosine receptor A1 agonist CCPA, or blocked by antagonist SPT. Thus, adenosine mediates protection by ischemic preconditioning in this specific rat heart model. 99mTc-glucarate imaging is not only useful in detecting early ischemia-reperfusion injury, but also invaluable in evaluating the effects of cardioprotective treatments. uantitative anal ses on dynamic images with 99m Tc-glucarate would make it possible to identify myocardial ischemia-reperfusion injury more accurate, and provide a unique tool for evaluation of cardioprotection. The FASTSPECT imaging with the ischenuc-reperfused rat heart model provides a solution-specific approach with high-resolution and fast dynamic acquisition for kinetic studies of new myocardial imaging agents as the evidence of its major role in the present study. (authors)

  4. Incremental value of combined 99MTc tetrofosmin parathyroid scintigraphy, rapid intra operative PTH assays and minimally invasive radio-guided surgery (MIRS) in optimizing parathyroidectomies

    International Nuclear Information System (INIS)

    Padma, S.; Kumar, S.; Babu, T.; Kumar, H.; Nair, V.; Nair, G.K.

    2004-01-01

    Objective: Aim of our study was to evaluate incremental diagnostic value of 99mTc Tetrofosmin parathyroid SPECT (TPSPECT), rapid intra operative quick parathyroid hormone measurement (QPTH) combined with radio guidance provided by scintillation probe (Minimally Invasive Radio guided Surgery MIRS) in parathyroid surgeries. While TPSPECT is an established investigation in preoperative workup of hyperparathyroidism patients , MIRS is a relatively new concept in Indian subcontinent. Methods: 29 pts (M: F = 18: 11), age range 16- 65 yrs (mean 41+ 9 yrs) having clinical and biochemical hyperparathyroidism underwent TPSPECT between Jan 02 -04, using 20 mci IV 99mTc Tetrofosmin. Pts with familial hyperparathyroidism , previous nodular goiters and previous neck irradiation were excluded from study. Scintigraphy comprised of immediate, delayed planar and SPECT imaging of neck and chest. Imagewise abnormal, persistent tracer uptake was considered positive for adenoma and diffuse uptake for hyperplasia. 26 pts underwent exploration (22 adenomas and 4 hyperplasias).18 pts had benefit of intraoperative QPTH. A select group (after Dec 2003) i.e. 9 pts got the assistance of radioguided probing. Peroperatively NM physician used cordless handheld gamma probe (Gamma Finder, World of Medicine, Germany) in neck and mediastinum to detect parathyroid adenoma / hyperplasias. A five fold increase in radioactive counts perceived by probe when compared to background was considered positive for parathyroid adenoma / hyperplasia. If PTH levels fell from baseline by at least 50%, the surgery was concluded as complete. Results: In all 22 pts suspected to have primary hyperparathyroidism TPSPECT identified adenomas (100 % sensitivity). While planar imaging had a sensitivity of 90.1% (20/22 pts), SPECT identified the adenoma in all pts. Interestingly only 3/22 pts had ectopic glands while 5 had more than one adenomas. The most commonly involved gland was left inferior. In secondary

  5. Optimization of working conditions of medical staff of isotopic diagnostic departments. Optimizatsiya uslovij truda meditsinskogo personala radiodiagnosticheskikh otdelenij

    Energy Technology Data Exchange (ETDEWEB)

    Ovsyannikov, A S [Akademiya Meditsinskikh Nauk SSSR, Moscow (USSR). Inst. Gigieny Truda i Professional' nykh Zabolevanij

    1989-01-01

    The study was undertaken to analyze the characteristics of the work of medical staff of isotopic diagnostic departments during use of {sup 99m}Tc isotope generators. The data on the functional load of physicians and paramedical staff were given along with the description of radiation doses and dose rates at various stages of work. The measures on optimization of labour conditions by means of the appropriate department's design, improvement of the regime of nurses' work and adequate allocation and utilization of medical equipment were developed.

  6. Production of radioisotopes at the Boris Kidric Institute of Nuclear Sciences at Vinca, Yugoslavia; Proizvodnja radioaktivnih izotopa

    Energy Technology Data Exchange (ETDEWEB)

    Teofilovski, C [Institute of Nuclear Sciences Boris Kidric, Vinca, Beograd (Serbia and Montenegro)

    1969-07-01

    The investigations in order to master the production of radioisotopes were commenced simultaneously with the beginning of RA nuclear reactor construction at Vinca, in 1956. A new organization division - Laboratory for chemistry of high activity accepting beside other problems also the programme for mastering the regular production of radioactive material was formed in 1959. Various problems during the realization of this programme have been solved, starting with the staff training for work with radioactive material on the high level activity (to 7500 Ci/source), construction and equipment of the laboratory area for safe work, up to development of the whole series of chemical-technological procedures and techniques for regular production of various radioactive products, as well as the methods for their chemical, radiometric and pharmaceutical control. Owing to the successful realization of this programme, the Institute 'Boris Kidric' supplies to-day regularly 110 organizations in the country with various radioactive products, applied in medicine, industry and research. The annual product of the radioactive solutions of radioisotopes J-131, Au-198, P-32, S-35 etc., amounts to about 75 Ci, radiographic sources Ir-192 and Co-60 to 2000 Ci and Co-60 sources for teletherapy and the other applications to many thousand curies (author) [Serbo-Croat] Paralelno sa pocetkom izgradnje nuklearnog reaktora RA u Vinci 1956. godine zapoceta su istrazivanja u oblasti osvajanja proizvodnje radioizotopa. 1958. god. formirana je nova organizaciona jedinica - Laboratorija za hemiju visoke aktivnosti, koja je, pored ostalog, prihvatila i program osvajanja redovne proizvodnje radioaktivnog materijala. U toku realizacije programa reseni su raznovrsni problemi pocev od pripreme kadrova za rad sa radioaktivnim materijalom na visokom nivou aktivnosti (do 7500 Ci/izvor), izgradnje i opremanja laboratorijskog prostora za bezbedan rad, do razvoja citavog niza hemijsko-tehnoloskih postupaka i tehnika za redovnu proizvodnju raznovrsnog radioaktivnog materijala kao i metoda za njegovu hemijsku, radiometrijsku i farmaceutsku kontrolu. Zahvaljujuci uspesnoj realizaciji ovog programa Institut 'Boris Kidric' danas redovno snabdeva 110 ustanova u zemlji raznovrsnim radioaktivnim materijalom, koji se primenjuje u medicini, industriji i istrazivackim ustanovama. Godisnja proizvodnja radioaktivnih rastvora radioizotopa J-131, Au-198, P-32, S-35 i dr, iznosi oko 75 Ci, radiografskih izvora Ir-192 i Co-60 oko 2000 Ci i izvora Co-60 za teleterapiju i druge primene vise hiljada kirija (author)

  7. Role of 99MTc-DTPA renal scintigraphy using gates protocol with extended acquisition time in evaluation of the function of pre-operative donor kidneys and post-operative remaining kidney

    International Nuclear Information System (INIS)

    Trinh Thi Minh Chau; Nguyen Xuan Canlh; Le Huu tam; Truong Quang Xuan

    2004-01-01

    Introduction: Radionuclide Methods have been extensively used in kidney transplantation. This non-invasive technique provides quantitative analysis of total and individual renal function as well as assessment of urinary outflow tract. Aim of this study was to evaluate renal function of potential kidney-donors and follow up post-nephrectomy kidney-donors by 99mTc-DTPA renal scintigraphy using Gates protocol with extended acquisition. MATERIALS AND Methods: This study included 72 living kidney donors. In addition to routine laboratory and radiological evaluations, a 99mTc-DTPA dynamic renal scintigraphy was acquired 15 second per frame for 30 minutes. Glomerular filtration rate (GFR) was calculated based on Gates protocol. Urinary outflow tract was assayed by renogram generated and consecutive dynamic renal images of up to 30 minute. Renal scintigraphy was also performed in follow-up of 37 post-nephrectomy kidney donors. Results 6 of 72 (8.3%) living related donors were excluded from nephrectomy due to reduced GFR of either total or individual kidney. One of 6 excluded donors had one non-functional kidney. No donors have shown urinary tract obstruction. In 66 kidney donors who were indicated nephrectomy, pre-nephrectomy mean total GFR, calculated by Gates method, was 108 mi/minute that was significantly higher than GFR result of 94 mi/minute by Cockcroft and Gault prediction equation (p 0.05). These results are not significant, indicative of functional compensation occuring after unilateral nephrectomy. Conclusion: Tc-99m DTPA dynamic renal scintigraphy using Gates protocol with extended acquisition time is a valuable simple radionuclide technique which is able to assess total and individual renal function and urinary outflow tract. This technique should be used as an integral part of the pre-operative evaluation contributing to the choice of nephrectomy side in potential kidney donors and as follow-up of post-operative remaining kidney. (authors)

  8. Synthesis and evaluation of the 99mtc-complexes of L-cysteine acetyldiglycine (a hybrid of MAG3 and L,L-EC) and of L-β-homocysteine acetyldiglycine

    International Nuclear Information System (INIS)

    Mang'era, K.; Vanbilloen, H.; Cleynhens, B.; Groot, T. de; Bormans, G.; Verbruggen, A.; Verbeke, K.

    2000-01-01

    L-Cysteine acetyldiglycine (L-CAG2), a hybrid compound of L,L-EC and MAG3, and its L-β-homocysteine analogue L-HAG2 were synthesized. After labeling with 99m Tc, 99m Tc-L-CAG2 and 99m Tc-L-HAG2 gave two peaks on high performance liquid chromatography. Urinary excretion of both isomers of 99m Tc-L-CAG2 and 99m Tc-L-HAG2 was slower than for the 'parent' complexes 99m Tc-MAG3 or 99m Tc-L,L-EC. Isomer B of 99m Tc-L-CAG2 showed pronounced kidney retention in mice (57% of ID in kidneys at 30 min postinjection), but further evaluation in baboon did not reproduce this phenomenon

  9. Detection of viral hepatitis B markers by radioimmunoassay in medical personnel. Vyyavlenie markerov virusnogo gepatita B u meditsinskogo personala radioimmunologicheskim metodom

    Energy Technology Data Exchange (ETDEWEB)

    Marievskij, V F; Lejbenzon, A S

    1990-10-01

    Results of revealing B markers of viral hepatitis (VHB) in medical personnel in the city of Zaporozhe by radioimmunoassay method are presented. By the frequency of revealing two markers (HB {sub s}Ag and anti-HB{sub s}) risk groups are indicated depending on the profession, age (length of service) of medical personnel.

  10. Os{sup 187}-isotope abundances in terrestrial and meteoritic osmium and an attempt to determine Re/Os-ages of iron meteorites; Anomalies dans l'abondance isotopique de l'osmium-187 dans l'osmium terrestre et meteoritique - Essai de determination de l'age des meteorites de fer au moyen du rapport Re/Os; Anomalii v rasprostranennosti izotopa osmiya-187 v zemnom i meteoritnom osmie i popytka opredeleniya vozrastov reniya/osmiya v zheleznykh meteoritakh; Anomalias en la abundancia isotopica del {sup 187}Os en el osmio terrestre y meteoritico. Ensayo para determinar la edad de los meteoritos de hierro por medio de la razon Re Os

    Energy Technology Data Exchange (ETDEWEB)

    Herr, W; Hoffmeister, W; Langhoff, J [Max-Planck-Institut fuer Chemie (Otto-Hahn-Institut) Mainz, Federal Republic of Germany (Germany); Geiss, J; Hirt, B; Houtermans, F G [Physikalisches Institut der Universitaet Bern (Switzerland)

    1962-01-15

    The isotopic composition of a large number of Os-samples from terrestrial platinum ores and from iron meteorites has been investigated by mass-spectrometry. The observed isotope-ratios Os{sup 187}:Os{sup 186} in Os/Ir-ores and in Os-samples, extracted quantitatively from iron meteorites, vary in limit from 0.88 to 1.41. These variations may be explained by the production of radiogenic Os following the decay of Re{sup 187}, a natural {beta}-emitter with the lowest known {beta}-energy. Neutron activation analysis proves that Re and Os are common trace elements in iron meteorites. As dating of these bodies by conventional methods suffers from enormous difficulties, the application of the Re/Os method has been studied. From our experiments a primordial Os{sup 187}:Os{sup 186} ratio is assumed and 'minimum ages' are discussed. They differ widely and are found presumably in the range from 3.7 to 5.6x10{sup 9} yr. (author) [French] Les auteurs ont etudie au moyen de la spectrometrie de masse la composition isotopique d'un grand nombre d'echantillons d'osmium provenant de minerais terrestres de platine et d'holosideres. Le rapport isotopique osmium-187/ osmium-186 observe dans l'osmiure d'iridium et dans les echantillons d'osmium extraits en quantite mesurable des holosideres varie entre 0,88 et 1,41. Ces variations peuvent etre expliquees par la production d'osmium radiogenicjue resultant de la desintegration du rhenium-187, emetteur naturel de rayonnements beta connu comme ayant la plus faible energie beta. L'analyse par activation des neutrons montre que le rhenium et l'osmium se trouvent communement a l'etat de traces dans les holosideres. Comme il est extremement difficile d'evaluer l'age de ces corps en recourant aux methodes classiques, les auteurs du memoire ont examine la possibilite d'utiliser le rapport Re/Os. Apres avoir assume de leurs experiences le rapport osmium-187/osmium-186, ils examinent la question des . Ceux-ci different sensiblement et semblent etre de l'ordre de 3,7 a 5,6 {center_dot} 10{sup 9} ans. (author) [Spanish] Los autores han investigado por espectrometria de masas la composicion isotopica de gran numero de muestras de osmio procedentes de minerales terrestres de platino y de meteorites de hierro. Las razones isotopicas {sup 187}Os : {sup 186}Os observadas en los minerales de Os/Ir y en las muestras de Os, extraidas cuantitativamente de meteoritos de hierro, varian entre 0,88 y 1,41. Estas variaciones pueden explicarse por la formacion de Os radiogenico a consecuencia de la desintegracion del {sup 187}Re, que es el emisor natural {beta} que posee la energia {beta} mas baja conocida. Los analisis por activacion neutronica demuestran que en los meteoritos de hierro se suelen encontrar vestigios do Re y Os. Como la determinacion de la edad de estos cuerpos con ayuda de los metodos clasicos tropieza con enormes dificultades, los autores han estudiado la posibilidad de aplicar un metodo basado en la evaluacion de la razon Re/Os. Despues de haber deducido experimentalmente una razon basica {sup 187}Os : {sup 186}Os, los autores examinan la cuestion de las edades minimas. Estas varian sensiblemente y estan al parecer comprendidas entre 3,7 y 5,6 x 10{sup 9} anos. (author) [Russian] Pri pomoshchi massovoj spektrometrii byl izuchen izotopnyj sostav bol'shogo chisla prob osmiya zemnykh platinovykh rud i zheleznykh meteoritov. Poluchennoe sootnoshenie mezhdu izotopami osmiya-187 i osmiya-186 v rudakh osmiya i zheleza i v probakh osmiya, kolichestvenno, izvlechennykh iz zheleznykh meteoritov, izmenyaetsya v predelakh ot 0,88 do 1,41. EHti izmeneniya mogut byt' ob{sup y}asneny obrazovaniem radiogennogo osmiya vsled za raspadom reniya-187, yavlya- yushchegosya prirodnym beta-izluchatelem s naibolee nizkoj izvestnoj beta-ehnergiej. Aktiva- tsionnyj analiz pri pomoshchi nejtronov dokazyvaet, chto renij i osmij yavlyayutsya obshchimi ehlementami zheleznykh meteoritov, soderzhashchimisya v nikh v nichtozhnykh kolichestvakh. Tak kak opredelenie vozrasta ehtikh tel obychnymi metodami predstavlyaet ochen' bol'shie zatrudneniya, byl izuchen metod ispol'zovaniya reniya/osmiya. Iz nashikh issledovanij bylo vyvedeno preobladayushchee sootnoshenie mezhdu osmiem-187 i osmiem-186; obsuzhdaetsya ikh ''minimal'nyj vozrast''. EHtot vozrast izmenyaetsya v znachitel'nykh predelakh i veroyatno zaklyuchaetsya v intervale ot 3,7-109 do 5,6-109 let. (author)

  11. Comparison of D2 receptor binding (123I-IBZM) and rCBF (99mTc-HMPAO) in extrapyramidal disorders

    International Nuclear Information System (INIS)

    Saur, H.B.; Bartenstein, P.; Schober, O.; Oberwittler, C.; Lerch, H.; Masur, H.

    1994-01-01

    The aim of this SPECT study was to determine whether there is a correlation between rCBF ( 99m Tc-HMPAO) and D2 receptor binding ( 123 I-IBZM) in disorders of the extrapyramidal system and in which situation the 99 MTc-HMPAO scan could predict the outcome of the 123 I-IBZM study. 13 patients with Parkinson's syndrome and 13 patients with hyperkinetic extrapyramidal disorders were studied. In all patients the two SPECT studies were performed within 2-7 days. ROIs were placed over the basal ganglia (BG), the frontal cortex (FC) and the cerebellum (CE). The ratios BG/FC and BG/CE were calculated. In both groups the scatter was lower when the frontal cortex was used as reference region. Among the patients with hyperkinetic extrapyramidal hyperkinetic extrapyramidal disorders the two patients with Huntington's chorea had lower rCBF and D2 receptor binding compared to other hyperkinetic extrapyramidal disorders. There was no correlation between D2 receptor binding and rCBF in the basal ganglia. The 99 MTc-HMPAO studies did not provide clinically useful information, except in Huntington's chorea. (orig.) [de

  12. Interna kontaminacija medicinski značajnim radionuklidima

    OpenAIRE

    Duraković, A.

    1986-01-01

    Sve češća primjena radioaktivnih izotopa u industriji, znanosti i medicini i mogućnost kontaminacije biosfere produktima nuklearne fisije iz radioaktivnih padavina kao rezultat nuklearnih pokusa predmet su zanimanja medicinskih stručnjaka. Među opasnosti koje prijete od radionuklida inkorporiranih u ciljnim organima spadaju različita oštećenja tkiva od ionizirajućeg zračenja i posebice maligne promjene na mjestima njihove retencije. U ovom se prikazu daju smjernice za razumijevanje mehanizama...

  13. Radionuclides and maternal lactation

    International Nuclear Information System (INIS)

    Zamora, H.H.

    1989-01-01

    The increase in the number of nuclear medicine centers, both official and private in the country, as well as the increase in the number of patients, due to the effectiveness of their diagnostic and therapeutic procedures, brings out new situations that must be studied from the point of view of radioprotection. This work makes a revision in the medical literature about procedures with radioisotopes during the maternal nursing period. In general, it is recommended to stop nursing for 24 hours for 99mtc test, and to resume it after the draining of the milky content. This can be done in spite of the sensitivity of the target organ of the baby, because the dosage will be below permissible limits accepted by international agencies with respect to diagnostic test and I-131 treatment, and if continuing nursing is desired, it is recommended to use other diagnostic or therapeutic procedures before discontinuing the most important nutritional resource at this age

  14. Work on the hot atom chemistry at the Institute of Nuclear Sciences Boris Kidric, Vinca, Yugoslavia; Hemija vruceg atoma

    Energy Technology Data Exchange (ETDEWEB)

    Veljkovic, S [Institute of Nuclear Sciences Boris Kidric, Vinca, Beograd (Serbia and Montenegro)

    1969-07-01

    A survey of work on hot atom chemistry from the establishment of the Institute up to now, where the role of Prof. P. Savic, should be specially emphasized, is given. The investigations in this domain during the first period, were directed to solve various problems in production of radioactive isotopes. Today these investigations are closely associated with the work in radiochemistry, physical chemistry of liquid and solid systems and fast reaction kinetics improving the development of these branches (author) [Serbo-Croat] Daje se pregled rada na hemiji vruceg atoma od osnivanja Instituta do danas, pri cemu se narocito istice uloga koju je u tome imao prof. P. Savic. Dok su u prvom periodu istrazivanja u ovoj oblasti doprinosila resavanju raznih problema proizvodnje radioaktivnih izotopa, ona su danas tesno povezana sa radom u radiohemiji, fizickoj hemiji tecnih i cvrstih sistema, kinetici brzih reakcija, doprinoseci sa svoje strane razvoju tih oblasti (author)

  15. Twenty years of chemistry associated with the needs and utilization of nuclear reactors at the 'Boris Kidric' Institute of nuclear sciences, Vinca, Yugoslavia; Dvadeset godina hemije vezane za potrebe i koriscenje nuklearnih reaktora u Institutu za nuklearne nauke 'Boris kidric' i Vinci

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1969-07-01

    This publication covers nine review papers on the following topics related to the needs and utilization of nuclear reactors in the Boris Kidric Institute of nuclear sciences during previous twenty years: radiochemistry, hot atom chemistry, isotope production, spent nuclear fuel reprocessing, chemistry of transuranium elements; liquid radioactive waste processing, purification of reactor coolant water by inorganic ion exchangers, research related to deuterium concentration processes, and chemical dosimetry at the RA reactor. [Serbo-Croat] Ova publikacija obuhvata devet radova, po sledecim naslovima, a odnose se na potrebe i uslove nuklearnih reaktora u Institutu za nuklearne nauke 'Boris Kidric' tokom prethodnih dvadeset godina: radiohemija, hemija vruceg atoma, proizvodnja radioaktivnih izotopa, prerada isluzenog nuklearnog goriva, hemija transuranskih elemenata, obrada radioaktivnih otpadnih voda, preciscavanje vode za hladjenje nuklearnih reaktora pomocu neorganskih jonoizmenjivaca, istrazivanje procesa za koncentrovanje deuterijuma i hemijska dozimetrija reaktora RA.

  16. Task 08/41, Low temperature loop at the RA reactor, Review I of materials planned for irradiation within the five-year plan of nuclear power development in Federal Peoples Republic of Yugoslavia; Zadatak 08/41, Niskotemperaturna petlja u reaktoru 'A', Pregled I materijala predvidjenih za ozracivanje petogodisnjim planom razvoja nuklearne energije FNRJ

    Energy Technology Data Exchange (ETDEWEB)

    Milenkovic, S; Milasin, N [Institute of Nuclear Sciences Boris Kidric, Vinca, Beograd (Serbia and Montenegro)

    1961-12-15

    For the purpose of designing the low-temperature loop at the RA reactor, a list of materials that would be irradiated in the reactor was made. This review includes materials which should be irradiated in for isotope production and materials to be irradiated for research and testing purposes. The neutron flux needed for materials testing should be much higher than presently available neutron flux of 10{sup 12} n/cm{sup 2} sec. [Serbo-Croat] Za potrebe projektovanja niskotemperaturne petlje na reaktoru RA nacinjen je pregled materijala za ozracivanje u reaktoru. Pregled sadrzi materijale za ozracivanje u cilju proizvodnje izotopa i materijale za specijalna ozracivanja u cilju ispitivanja materijala. Za ispitivanje materijala potreban bi bio fluks neutron koji je znatno veci od raspolozivog fluksa od 10{sup 12} n/cm{sup 2} sec.

  17. Development of methods for theoretical analysis of nuclear reactors (Phase II), I-V, Part IV, Fuel depletion; Razrada metoda teorijske analize nuklearnih reaktora (II faza), I-V, IV Deo, Promena izotopnog sastava goriva

    Energy Technology Data Exchange (ETDEWEB)

    Pop-Jordanov, J [Institute of Nuclear Sciences Boris Kidric, Vinca, Beograd (Serbia and Montenegro)

    1962-10-15

    This report includes the analysis of plutonium isotopes from U{sup 238} depletion chain. Two theoretical approaches for solving the depletion of fuel are shown. One results in the system of differential equations that can be solved only by using electronic calculators and the second, Machinari-Goto method enables obtaining analytical equations for approximative values of particular nuclei. In addition, differential equations are given for different approximation levels in calculating Pu {sup 239}, as well as relations between the released energy and irradiation. Ova faza obuhvata analizu stvaranja izotopa plutonijuma u lancu U{sup 238}. Prikazana su dva teorijska pristupa resavanju problema 'konverzije goriva', jedan dovodi do sistema diferecijalnih jednacina za cije je resavanje neophodno koriscenje elektronskih racunskih masina, i drugi, Machinari-Goto metod koji omogucava da se dobiju analiticki izrazi vrednosti aproksimacije pojedinih jezgara. Osim toga date su diferencijalne jednacine raznih stepena aproksimacije u racunanju Pu {sup 239}, kao i veze izmedju oslobodjene energije i ozracivanja.

  18. Adenoma paratiroideo ectópico mediastinal: Diagnóstico por sonda de detección gamma y resección por videotoracoscopia Ectopic mediastinal parathyroid adenoma: Detection with a radioisotopic probe and resolution with videothoracoscopy

    Directory of Open Access Journals (Sweden)

    Daniel Moncet

    2006-10-01

    Full Text Available Presentamos el caso de una mujer de 66 años con diagnóstico de hiperparatiroidismo primario por adenoma paratiroideo ectópico mediastinal realizado por gammagrafía paratiroidea con 99mtc-metoxi-isobutil-isonitrito (Tc99-MIBI. Fue intervenida exitosamente mediante la técnica de videotoracoscopia. Durante el procedimiento se utilizó la medición de parathormona y a los 10 minutos de extirpado el adenoma se obtuvo un descenso mayor del 50% del basal. La sonda de detección gamma no fue efectiva in situ por la superposición del radioisótopo con el miocardio pero confirmó la radioactividad dentro del quirófano una vez extirpado el adenoma. La paciente normalizó los valores de calcemia y parathormona en el postoperatorio y permaneció normocalcémica luego de 9 meses de seguimiento. En nuestro caso, la localización prequirúrgica y el monitoreo de parathormona intraoperatoria fueron de gran utilidad para el éxito quirúrgico, la sonda detectora marcada con Tc99-MIBI no fue efectiva in situ pero confirmó la radioactividad una vez extirpado el adenoma. El tratamiento quirúrgico endoscópico por videotoracoscopia fue bien tolerado, menos doloroso que la toracotomía y acortó el tiempo de internación.We report a 66 years old woman with a diagnosis of primary hyperparathyroidism. Localization to mediastinum was obtained with parathyroid scintigraphy using 99mtc-methoxy-isobutyl-isonitrite (Tc99-MIBI. The patient was successfully operated upon by means of a videothora-coscopic approach. During the procedure serum parathormone was measured before and 10 minutes after adenomectomy, showing a more than 50% reduction from the basal level. An attempt to detect the precise site of the adenoma with a Tc99-MIBI probe was unsuccessful because of its proximity to the myocardium, but radioactivity was confirmed on the surgical specimen after resection. The patient's calcemia and parathormone levels became normal during the postoperative course and she

  19. Brain Single Photon Emission Computed Tomography in Anosmic Subjects Ater Closed Head Trauma

    Directory of Open Access Journals (Sweden)

    Roozbeh Banan

    2011-01-01

    Full Text Available Anosmia following head trauma is relatively common and in many cases is persistent and irreversible. The ability to objectively measure such a decline in smelling, for both clinical and medicolegal goals, is very important. The aim of this study was to find results of brain Single Photon Emission Computed Tomography (SPECT in anosmic subjects after closed head trauma. This case-control cross sectional study was conducted in a tertiary referral University Hospital. The brain perfusion state of nineteen anosmic patients and thirteen normal controls was evaluated by means of the SPECT with 99mtc- ECD infusion- before and after olfactory stimulation. The orbitofrontal lobe of the brain was assumed as the region of interest and changes in perfusion of this area before and after the stimulations were compared in two groups. The mean of brain perfusion in controls before and after the stimulation was 8.26% ± 0.19% and 9.89% ± 0.54%, respectively (P < 0.0001. Among patients group, these quantities were 7.97% ± 1.05% and 8.49% ± 1.5%, respectively (P < 0.004. The difference between all the measures in cases and controls were statistically significant (P < 0.0001. There were no differences in age and sex between two groups. The brain SPECT is an objective technique suitable for evaluating anosmia following the head trauma and it may be used with other diagnostic modalities

  20. Audit Calculations of ATWS for Ulchin Unit 1 and 2 Power Uprate

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Jun Soo; Huh, Byung Gil; Choi, Yong Seog; Seul, Kwang Won [Korea Institute of Nuclear Safety, Daejeon (Korea, Republic of)

    2013-10-15

    In this study, the regulatory audit calculation for ATWS of Ulchin Unit 1 and 2 with 4.5% power uprate was performed to support the licensing review and to confirm the validity of licensee's calculation. In order to simulate the transient behavior of ATWS initiated by a loss of feed water, the systems of Ulchin Unit 1 and 2 was modeled with MARS-KS 1.3. In this study, the regulatory audit calculation of ATWS for Ulchin 1 and 2 with 4.5% power uprating and 99% MTC in the specific cycle designs was performed. It is conformed that the analysis results of ATWS for Ulchin 1 and 2 power uprate meets the RCS pressure acceptance criteria. An anticipated transient accompanied by a failure in the Reactor Trip System (RTS) to shut down the reactor is defined as an Anticipated Transient Without Scram (ATWS). Under certain postulated conditions, the ATWS could lead to Reactor Coolant system (RCS) pressure boundary fracture and/or core damage. For a conventional pressurized water reactor (PWR), the temperature corresponding to the NSSC notice No.2013.09(Performance Criteria for ECCS of the Pressurized Water Reactor Nuclear Power Plants), 1204 .deg. C and the pressure corresponding to the ASME Boiler and Pressure Vessel Code service level C stress, 221.5 bar is assumed to be an unacceptable plant condition against ATWS, above which the RCS pressure boundary could deform to the point of inoperability and the safe shutdown by injection of borated water could be challenged. Such potentially excessive RCS overpressure may occur in the ATWS initiated from a loss of heat sink. Currently, the modification of Ulchin 1 and 2 operating license for 4.5% power uprate is under review.

  1. Incomplete palmar fracture of the proximal extremity of the third metacarpal bone in horses: ten cases (1981-1986)

    International Nuclear Information System (INIS)

    Lloyd, K.C.K.; Koblik, P.; Ragle, C.; Wheat, J.D.; Lakritz, J.

    1988-01-01

    In 4 adult horses, simple, non displaced, incomplete fracture of the proximal extremity of the third metacarpal bone (MC3) was identified radiographically only on the dorsopalmar projection. Lameness was slight to moderate. Although nerve blocks of the foot and fetlock did not alter the lameness, high palmar regional nerve block improved the gait in 1 of the 2 horses on which it was performed. Pain on palpation or swollen distal accessory (inferior check) ligament, flexor tendons, and suspensory ligament were not found in any horse. The fracture was localized to the palmar surface of the proximal extremity of the MC3 on the basis of the intense uptake of radiopharmaceutical (99MTc-labeled sodium medronate) observed in that area during the soft tissue and delayed bone phases of a nuclear scintigraphic examination (nuclear scan) performed concurrently with radiography. Of 4 horses evaluated 6 months after the initial diagnosis, 3 had medullary sclerosis without radiographic evidence of fracture; results of follow-up nuclear scintigraphy performed in one of these horses at the same time were normal. Incomplete fracture also was suspected in another 6 adult horses with clinical lameness referable to the proximal extremity of the MC3. Although a fracture line could not be seen radiographically, trabecular hypertrophy and/or medullary sclerosis of the proximal extremity of the MC3 were detected on the dorsopalmar projection. Further, during nuclear scintigraphy, an intense uptake of the radiopharmaceutical was observed on the palmar aspect of the proximal extremity of the MC3 in all 6 horses

  2. Influence of radiation on the blood-brain barrier and optimum time of chemotherapy

    International Nuclear Information System (INIS)

    Qin, D.X.; Zheng, R.; Tang, J.; Li, J.X.; Hu, Y.H.

    1990-01-01

    A pilot study of the destructive effects of radiation on the blood-brain barrier (BBB) was made on 14 patients with localized and limited brain tumors by 99MTc-GH imaging from August 1988 to November 1989. Count/pixel data were obtained from the unirradiated, irradiated, and tumor areas before and after radiotherapy of 30-40 Gy. It was observed that the BBB in the unirradiated area outside the radiation portal was not changed and the degree of destructive effect on the BBB in the irradiated normal area was directly proportional to the radiation dose. For 30-40 Gy, the count/pixel change enhances to average 24.7% [(147.6-118.4)/118.4], and (c) the BBB in the tumor area is partially destroyed on an average of 22.1% [(206.8-169.4)/169.4] by the tumor. The radiotherapy further enhances this effect to an average of 74.7% [(206.8-118.4)/118.4]. Case 3 showed that before radiation, the degree of destructive effect on the BBB in the tumor area was 22% [(167-137)/137] higher than normal brain tissue. After a dose of 30 Gy of irradiation, it increased to 76.7% [(242-137)/137]; 8 months later it decreased to 17% [(160.3-137)/137]. It has been proven that the BBB can recover at least partially. Based on these observations, the authors believe that in the combined treatment of operated brain tumors, radiotherapy should precede chemotherapy so as to enhance the destruction of the BBB, facilitating the incorporation of drugs into the tumor. The dose at which to start chemotherapy is 20-30 Gy

  3. Operation, maintenance and utilization of the RA reactor, Annual report 1978; Pogon, odrzavanje i eksploatacija reaktora RA, Izvestaj o radu u 1978. godini

    Energy Technology Data Exchange (ETDEWEB)

    Milosevic, M [Institute of Nuclear Sciences Boris Kidric, Vinca, Beograd (Serbia and Montenegro)

    1978-12-15

    It has been planned for 1978 that the RA reactor would be operated for 158 dana at nominal power of 6.5 MW meaning production of 24 648 MWh. The plan was fulfilled since 24 652 MWh was produces. Reactor operation for 158 days is relevant to reactor operation for 200 days in the period before 1975. The reason is increased neutron flux achieved due to improved fuel management and the characteristics of the new 80% enriched fuel. At the end of 1978 the reactor core contained 45% of 80% enriched fuel elements. Increase of neutron flux has shortened the typical time needed for irradiation of the most important samples for isotope production. This significant success in reactor operation is at the same time an obligation for increasing its utilization. Some new trends proposed for increasing reactor utilization capacities were presented at the Conference on utilization of research nuclear reactors in Yugoslavia held in May 1978. [Serbo-Croat] Reaktor RA imao je u planu za 1978. godinu 158 dana rada na nominalnoj snazi od 6.5 MW, sto odgovara radu od 24 648 MWh. Ostvareno je 24 652 MWh sto znaci da je plan ostvaren. Rad reaktora od 158 dana odgovara radu reaktora od 200 dana u periodu pre 1975. godine. Razlog je povecanje neutronskog fluksa zahvaljujuci usavrsenom rukovanju gorivom i karakteristikama novog 80% obogacenog goriva. Krajem 1978. godine 45% jezgra reaktora bilo je popunjeno novim 80% obogacenim gorivom. Povecani neutronski fluks omogucio je skracenje vremena ozracivanja vaznih uzoraka za proizvodnju radioaktivnih izotopa. Ovaj znacajan uspeh je istovremeno obaveza znatno veceg iskoriscenja reaktora RA. Rezultati napora da se postigne vece iskoriscenje reaktora RA prezentirani su na Konferenciji o koriscenju nuklearnih reaktora u Jugoslaviji koja je odrzana u maju 1978.

  4. Report of the Technology Service - Annex B; Prilog B - Izvestaj o radu tehnoloske sluzbe

    Energy Technology Data Exchange (ETDEWEB)

    Cupac, S; Vukadin, Z [Institute of Nuclear Sciences Boris Kidric, Vinca, Beograd (Serbia and Montenegro)

    1992-01-01

    svojina Instituta u Krakovu, i spektrometra za merenje vremena preleta neutrona izradjenog u Institutu. Ovaj prilog sadrzi i analizu mogucnosti za neutronsku radiografiju i razvoj proizvodnje radioaktivnih izotopa, kao i dozimetrijske podatke.

  5. Operation and maintenance of the RA Reactor in 1985, Part 1, Annex B - Report of the Technology Service; Deo 1 - Pogon i odrzavanje nuklearnog reaktora RA u 1985. godini - Prilog B - Izvestaj o radu tehnoloske sluzbe

    Energy Technology Data Exchange (ETDEWEB)

    Martinc, R; Vukadin, Z; Stosic, O; Cupac, S [Institute of Nuclear Sciences Boris Kidric, Vinca, Beograd (Serbia and Montenegro)

    1985-12-01

    Technology service is established according to the need of unified technology control of the reactor, based on the organizational structure developed in USA, a part of which was applied at the Krsko NPP. Tasks of this service are: regular control and recording of operating reactor parameters under steady state and accidental conditions; control of chemical state of the reactor core (control of Ph values and electro conductivity of the heavy water and technical water); dosimetry parameters control and recording; safety and optimisation analyses when planning reactor core modifications; (changing the type of fuel, design of new components); cooperation with the reactor users during isotope production, activation analyses, application of neutron beams; participating in research programs; planning refueling. The most important task performed by this service was conversion of the core from 2% to 80% enriched fuel elements. A methodology for optimizing the reactor application was developed. Operation of the heavy water purification system, heavy water parameters, and operation of the gas system were controlled. Radiation and contamination levels in the working environment were measured, individual and collective doses. [Serbo-Croat] Tehnoloska sluzba uspostavljena je u skladu sa ispoljenim potrebama jedinstvene tehnoloske kontrole reaktora, oslanjajajucui se na organizacionu semu koja je razvijena u SAD, a cija je jedna varijanta primenjena na NE Krsko. Zadaci sluzbe su obavljanje sledecih zadataka: redovna kontrola i evidencija radnih parametara reaktora u redovnim i akcidentalnim uslovima; kontrola hemijskog rezima u reaktoru (kontrola PH vrednosti i elektroprovodnosti teske i tehnicke vode); kontrola i evidencija tehnicke dozimetrije; sigurnosne i optimizacione analize prilikom planiranja izmena na reaktoru (promene vrste goriva, izgradnja novih elemenata opreme); saradnja sa korisnicima reaktora prilikom prozivodnje izotopa, aktivacione analize, koriscenja

  6. The Determination of the Half-Life of U{sup 238} by Absolute Counting of {alpha} Particles in a 4 {pi}-Liquid Scintillation Counter; Determination de la periode de l'U{sup 238} au moyen du comptage absolu de particules {alpha} dans un comtpeur 4 {pi} a scintillateur liquide; Opredelenie perioda poluraspadda U{sup 238} posredstvom absolyutnogo scheta {alpha}-chastits v zhidkostnom stsintillyatsionnom schetchike 4 {pi}; Determinacion del periodo del U{sup 238} por recuento absoluto de las particulas {alpha} con un contador 4 {pi} de centelleador liquido

    Energy Technology Data Exchange (ETDEWEB)

    Steyn, J; Strelow, F W. E. [Council of Scientific and Industrial Research, Pretoria (South Africa)

    1960-06-15

    }-chastits. Uran byl poluchen iz produktov ego raspada ehkstraktsiej metil-izobutilketona , i obraztsy ehtogo rastvora byli dobavleny neposredstvenn o v zhidkij stsintillyator. Bylo predprinyato kolichestvenno e issledovanie otdeleniya urana iz toriya s pomoshch'yu metoda ehkstraktsii. Predpolozhiv, chto U{sup 238} i U{sup 234} nakhodyatsya v ravnovesii, i sdelav popravku na prisutstvie U{sup 235}, byli podschitany udel'naya aktivnost' izotopa U{sup 238} i period ego poluraspada. (author)

  7. Application of the {beta}-Decay of Te{sup 132} for the Preparation of I{sup 132} -Labelled Molecules; Application de la Desintegration {sup 132}Te {beta}{sup -} -> {sup 132}I a la preparation de Molecules Marquees; ИСПОЛЬЗОВАНИЕ {beta}-РАСПАДА Te{sup 132} - J{sup 132} ДЛЯ ПОЛУЧЕНИЯ МЕЧЕНЫХ МОЛЕКУЛ; Preparacion de Moleculas Marcadas Aplicando la Desintegracion {sup 132}Te {beta}{sup -} {sup 132}I

    Energy Technology Data Exchange (ETDEWEB)

    Adloff, J. -P.; Adloff-Bacher, M. [Departement de Chimie Nucleaire, Centre de Recherches Nucleaires, Strasbourg (France)

    1963-03-15

    de gases y los diversos compuestos, marcados por radiosintesis, se separan por destilacion en presencia de portadores. Los productos marcados pueden resultar de reacciones de intercambio isotopico o de sustitucion y fragmentacion. En ciertos casos, el empleo de un medio organico conveniente permite lograr una marcacion practicamente especifica. (author) [Russian] Korotkij period poluraspada izotopa J{sup 132} (T{sub 1/2} = 2,3 chasa), kotoryj opravdyvaet Interes, projavljaemyj k nemu v biologii i: medicine, i kotoryj javljaetsja svoego roda radioaktivnym indikatorom, predstavljaet vmeste s tem samoe bol'shoe neudobstvo, kogda idet rech' o provedenii sinteza mechenyh molekul. Otmechaetsja vozmozhnost' ispol'zovanija himicheskoj reaktivnosti 'dochernego' izotopa joda, obrazujushhegosja v rezul'tate raspada Te{sup 1}'3{sup 2} dlja bystrogo poluchenija mechenyh molekul s bol'shoj udel'noj aktivnost'ju. Jeta reaktivnost' voznikaet iz jenergii vozbuzhdenija joda, poduchaemoj v rezul'tate rezkogo izmenenija zarjada jadra v processe raspada, a takzhe vnutrennej konversii, soprovozhdajushhejsja {beta}-izlucheniem, sledujushhej za Je-raspadom. Jod-132 obrazuetsja v sisteme, prednaznachennoj dlja mechenija; naibolee podhodjashhej himicheskoj formoj ishodnogo komponenta javljaetsja chetyrehhloristyj Te{sup 132} v opredelennom organichjoskom rastvo rntele. V svjazi o jetim issledovanijam podvergalis' neskol'ko sistem (aromaticheskie uglevodorody i proizvodnye, spirty i pr.), Posde obluchenija v techenie neskol'kih chasov organicheskij rastvor analizirovalsja metodom gazovoj hromatografii. Razlichnye mechenye komponenty otdeljalis' putem distilljacii s nositelem. Mechenye produkty mogut byt' polucheny v rezul'tate reakcij izotopnogo obmena, zameshhenija i razlozhenija. Ispol'zovanie podhodjashhej organicheskoj sredy pozvoljaet v opredelennyh sluchajah proizvodit' na praktike specificheskoe mechenie. (author)

  8. First Results of a Systematic Study of Internal Contamination Due to Fall-Out; Premiers Resultats d'une Etude Systematique des Contaminations Internes Consecutives aux Retombees Radioactives; 041f 0415 0420 0414 ; Resultados Iniciales de un Estudio Sistematico de las Contaminaciones Internas Debidas a la Precipitacion Radiactiva

    Energy Technology Data Exchange (ETDEWEB)

    Pellerin, P.; Moroni, J. P.; Remy, M. L. [Travail du Service Central de Protection Contre les Rayonnements Ionisants, Ministere de la Sante Publique, Paris (France)

    1964-11-15

    organismo humano tendria capital importancia, pero la medicion directa de este isotopo mediante el antropogammametro no puede realizarse cuando se trata de bajas actividades. Por lo tanto, los autores procuraron evaluar el orden de magnitud de dicha carga por dos metodos diferentes: primeramente, el estudio del cesio-137, cuya concentracion en las precipitaciones radiactivas sigue una evolucion sensiblemente paralela al del estroncio-90, permite hallar una primera aproximacion. Ademas, los autores midieron la excrecion urinaria de estroncio-90 en cierto numero de sujetos, con el proposito de deducir asi la carga total o, por lo menos, encontrar un limite superior para la concentracion de dicho isotopo. (author) [Russian] S sentjabrja 1961 goda Central'naja sluzhba zashhity ot ionizirujushhih izluchenij provela svyshe 500 obsledovanij s pomosh'ju schetchika dlja izmerenija radioaktivnosti vsego organizma cheloveka. Mnogie lica obsledovalis' v techenii treh ili shesti mesjacev . Pri jetih obsledovanijah chasto ispol'zovalsja radioanaliz mochi, v celom radiohimicheskomu issledovaniju predshestvovalo sistematicheskoe izuchenie obrazcov mochi s pomosh'ju gamma-spektrometrii.Sravnitel'noe izuchenie rezul'tatov jetih razlichnyh issledovanij pozvoljaet vyjavit' nekotorye fakty, otnosjashhiesja k vnutrennemu zarazheniju v rezul'tate radioaktivnyh vypadenij: 1. Cezij-137 javljaetsja edinstvennym iskustvennym radioizotopom, kotoryj postojanno obnaruzhivalsja pri obsledovanijah s pomoshh'ju schetchika dlja izmerenija aktivnosti vsego organizma. Jevoljucija obshhego srednego soderzhanija izotopa mozhet byt' proslezhena v techenie vsego perioda vremeni, otvedennogo na vse issledovanija. Dopolnitel'no mozhno otmetit' izmenenija, i k tomu zhe obychnye, radioaktivnogo zarazhenija v zavisimosti ot pola. 2. Chto kasaetsja obychno vstrechajushhihsja slabyh aktivnostej, to nam udalos' izuchit' svjaz' mezhdu vydeleniem s mochoj cezija-137 i obshhim soderzhaniem jetogo izotopa v organizme. Rezul

  9. Human Internal Contamination with Strontium-90 Titanate; Contamination Interne du Corps Humain par le Titanate de Strontium 90; 0412 041d 0414 ; Contaminacion Interna del Cuerpo Humano con Titanato de Estroncio-90

    Energy Technology Data Exchange (ETDEWEB)

    Bradley, F. J.; Wald, N.; Wechsler, R. L. [Graduate School of Public Health and School of Medicine, University of Pittsburgh, Pittsburgh, PA (United States)

    1964-11-15

    'zovalis' tri metoda. Pervyj metod- izmerenie obluchenija vsego organizma. Ono provodilos' d-rom Ch.Millerom v Argonskoj nacional'noj laboratorii, chto pozvolilo opredelit' tol'ko verhnij predel iz-za nejarko vyrazhennogo spektra tormoznogo izluchenija stroncij-90 - ittrij-90 i ukazalo na pervonachal'noe soderzhanie radioaktivnosti vo vsem organizme ravnoe'4,8 mkkjuri. Vtoroj metod - sbor vsego kolichestva mochi i- kala dal 5 mkkjuri dlja pervyh 20 dnej.: Putem soedinenija jetogo kolichestva s predpolagaemym kolichestvom, ostavshimsja v organizme,bylo polucheno pervonachal'noe1 soderzhanie radioaktivnosti vo vsem-organizme 5,2. mkkjuri. Tretij metod -opredelenie .radioaktivnosti krovi ukazal na pervonachal'noe soderzhanie radioaktivnosti vo vsem organizme ravnoe -6 mkkjuri. Sootnoshenie vydelenija izotopa s mochoj i kalom v pervye 20.dnej sostavljalo 15,: 1 i 94% vydeljajushhegosja stroncija-90 prohodilo cherez zheludochno-kishechnyj trakt. Odnako interesno otmetit', chto znachitel'naja frakcjja byla nesomnenno rastvorima. K 20 dnju posle avarii bylo podschitano', chto zaderzhka izotopa v organizme sostavljala tol'ko 5% ot obshhego pogloshhenija. Daetsja opisanie metodov, ispol'zovavshihsja v jetot'period, dlja uvelichenija vyvedenija s'kalom s pomoshh'ju- MgSO i vydelenija s mochoj putem kombinacii gljukonata kal'cija's NH{sub 4}Cl. Predstavleny posledujushhie sposoby vyvedenija -odnovremennaja ocenka ostavshegosja v organizme kolichestva izotopa. (author)

  10. Two Cases of Chronic Occupational Exposure to Radioactive Materials; Deux Cas d'Exposition Professionnelle Chronique a des Matieres Radioactives; 0414 0412 0414 ; Dos Casos de Exposicion Cronica Profesional a Sustancias Radiactivas

    Energy Technology Data Exchange (ETDEWEB)

    Rundo, J. [United Kingdom Atomic Energy Authority, Atomic Energy Research Establishment, Harwell, Berks. (United Kingdom)

    1964-11-15

    de estroncio en el organismo humano mostro que los resultados eran compatibles con una absorcion cronica que duro 4 anos (hasta 1957), y que despues de esta ultima fecha no habia habido absorcion considerable, sin embargo como la velocidad de excrecion observada en 1963 fue cinco veces mayor, como minimo, que la calculada, pudiera haber habido alguna pequefla absorcion poco antes de efectuar las mediciones en 1963. La retencion de estroncio-90 por el sujeto B puso de manifiesto un perfodo biologico de unos 6 a, lo que concuerda con el valor calculado a partir de la velocidad de excrecion (4,5 a 8,0 a). Despues de un aumento inicial del cuadruple, el contenido de torio-228 del sujeto A disminuyo exponencialmente entre 1959 y 1963 con un periodo efectivo de 1,4 a, como mfnimo. El contenido del sujeto B aumento de 1959 a 1960, pero la disminucion registrada de 1950 a 1963 no se diferencio apreciablemente de la debida a la desintegracion radiactiva con un perfodo de 1,90 a. La memoria termina con una discusion del valor del exponente de la ecuacion que expresa en forma exponencial la retencion de radio en el organismo humano. (author) [Russian] V doklade privodjatsja rezul'taty i interpretacija izmerenij radioaktivnosti organizma i vydelenij u dvuh chelovek s dlitel'noj (do 16 let) istoriej obluchenija radiem-226, stronciem-90 i toriem-228. Izmerenija proizvodilis' v techenie 1957, 1959, 1960 i 1963 godov. U pacienta A ne obnaruzheno zametnogo snizhenija soderzhanija radija v period mezhdu 1957 (0,13 mkkju.ri) i 1963 (0.14 mkkjuri), v 1959 ono bylo na 30%vyshe. Skorost' vydelenija v 1957 godu byla znachitel'noj soglasno modeli zaderzhki, vychislennoj s pomoshh'ju uravnenija silovoj funkcii, pri hronicheskom pogloshhenii porjadka 2 mkkjuri v den' v techenie predydushhih desjati let. Znachitel'no bolee nizkaja skorost' vydelenija nabljudalas' v 1963 godu, chto ukazyvaet na otsutstvie novogo postuplenija izotopa. Soderzhanie radija u pacienta V snizilos' s 1,19 mkkjuri v

  11. Interpretation of Bioassay Data; Interpretation des Donnees de l'Analyse d'Echantillons Biologiques; Interpretatsiya dannykh biologicheskikh issledovanij; Interpretacion de Datos Obtenidos por Bioanalisis

    Energy Technology Data Exchange (ETDEWEB)

    Dolphin, G. W.; Jackson, S. [Health Physics and Medical Division, Atomic Energy Research Establishment, Harwell, Berkshire (United Kingdom)

    1964-10-15

    dlja izotopov kazhdoj iz jetih grupp. Podcherkivaetsja, chto posle diagnostiki sluchajnogo popadanija v organizm izotopa zhelatel'no provesti seriju analizov mochi, chtoby izmerit' skorost' vydelenija izotopa s mochoj za sootvetstvujushhij period vremeni. Takim obrazom, netochnosti v kazhdom otdel'nom sluchae, svjazannye s kolebaniem skorosti vydelenija, mogut byt' svedeny k minimumu. Neskol'ko drugim mozhet byt' podhod v sluchae vzjatija prob pri obychnom obsledovanii gruppy personala. Imejushhiesja dannye otnositel'no obmena radioizotopov ispol'zujutsja dlja ocenki pogranichnogo urovnja, a imenno - skorosti vydelenija s mochoj, sootvetstvujushhej izbrannomu urovnju soderzhanija v organizme. Vazhno, chtoby izmerenija pri obychnom obsledovanii proizvodilis' s maksimal'noj tochnost'ju i tshhatjol'no registrirovalis'. Jeti izmerenija mogut byt' ispol'zovany v znachitel'noj mere dlja ocenki hronicheskogo postuplenija izotopa. Predstavleny vyvody po imejushhimsja dannym ob obmene i vydelenii s mochoj tritija, cezija, urana, stroncija, radija i plutonija u cheloveka. (author)

  12. Nuclear Reactor RA Safety Report, Vol. 1, Introduction; Izvestaj o sigurnosti nuklearnog reaktora RA, Knjiga 1, Uvod

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1986-11-01

    i citavog primarnog kola reaktora kobaltom; 1970. godine - zbog slanja teske vode u Francusku na izotopsku regeneraciju; 1979/80. i 1983. godine - zbog talozenja aluminijum oksihidrata na kosuljicama gorivnih elemenata u aktivnoj zoni reaktora i 1985/86. godine - zbog rekonstrukcije sistema ventilacije i izgradnje sistema za hladjenje jezgra reaktora u nuzdi. RA je tip teskovodnog istrazivackog reaktora sa sudom. Kod njega teska voda sluzi i kao moderator neutrona i kao primarni hladilac. Od pocetka rada, na reaktoru je korisceno 2% obogaceno uransko metalno gorivo. Od 1976. godine, na reaktoru je pocelo da se delimicno koristi 80% obogaceno oksidno uransko gorivo, da bi se od 1981. godine, na reaktoru koristilo isklucivo ovo visokoobogaceno gorivo. Reaktor RA je tako projektovan da mu snaga u normalnom radnom rezimu bude 6,5 MW, a u forsiranom 10 MW. Kao izvor neutrona, reaktor je namenjen za istrazivanja u oblasti reaktorske i neutronske fizike, fizike cvrstog stanja, radijacione hemije, biologije, a narocito za proizvodnju readioaktivnih izotopa. Reaktor RA su izgradila jugoslovenska gradjevinska i montazna preduzeca, na osnovu sovjetskog projekta. U SSSR su fabrikovane glavne komponente njegovih sistema i uredjaja.

  13. The Use of Technetium-99m as a Clinical Scanning Agent for Thyroid, Liver and Brain; Utilisation du {sup 99m}Tc comme Agent d'Exploration Clinique de la Thyroide, du Foie et du Cerveau; Ispol'zovanie Tc{sup 99m} kak klinicheskogo agenta pri skennirovanii shchitovidnoj zhelezy, pecheni i mozga; Empleo del {sup 99m}Tc como Agente para la Exploracion Clinica de la Tiroides, el Higado y el Cerebro

    Energy Technology Data Exchange (ETDEWEB)

    Harper, P. V.; Lathrop, K. A.; McCardle, R. J.; Andros, G. [Argonne Cancer Research Hospital and Department of Surgery, University of Chicago Hospitals and Clinics, Chicago, IL (United States)

    1964-10-15

    selectivamente por la tiroides, el estomago y las glandulas salivales. Los datos facilitados por la excrecion indican que su periodo biologico es de unos 2 d. Con una dosis de irradiacion calculada en 100 mrad para la glandula y en 5 mrad para el cuerpo entero, se pueden efectuar exploraciones tiroideas de muy buena calidad entre meedia hora y una hora despues de administrar 1 me de esta sustancia lo que representa una gran ventaja sobre el {sup 131}I. El TcO{sub 4} no atraviesa libremente la barrera hematoencefalica, lo que ha permitido obtener excelentes imagenes del cerebro con un tiempo de exploracion de 2 a 5 min aprovechando el elevado fndice de recuento correspondiente a dosis de 5 a 10 me de {sup 99m}Tc. Como el tiocianap pentavalente se disuelve en una emulsion de grasa, gran parte del {sup 99m}Tc se localiza en el higado; en este caso el elevado fndice de recuento permite tambien proceder a una rapida exploracion de esta glandula con un'mayor poder de resolucion. Es muy probable que este tipo de mejores resultados aun utilizando sondas mas eficaces y adaptando los parametros biologicos y quimicos a condiciones optimas. (author) [Russian] Pri poiskah ''ideal'nogo'' izotopa dlja skennirovanija tehnecij-99m, povidimomu, imeet mnogo preimushhestv. Jeto veshhestvo javljaetsja chistym gamma-izluchatelem s jenergiej 140 kjev (9% konveosija) otsutstvii izluchenija chastic, imeet shestichasovoj fizicheskij period poluraspada, umerennuju stoimost', javljaetsja dostupnym dochernim produktom molibdena-99 s periodom poluraspada 2,7 dnja, ot kotorogo on legko otdeljaetsja na kolonke s okis'ju aljuminija. V obychnoj forme (Tc{sup 99m}O{sub 4}{sup -}) on raspredeljaetsja v organizme tak zhe kak CIO{sub 4}{sup -} i J, bystro rasprostranjajas' vo vnekletochnom prostranstve, izbiratel'no zahvatyvaetsja shhitovidnoj zhelezoj, zheludkom i sljunnymi zhelezami. 5 sootvetstvii s dannymi vydelenija period poluvyvedenija sostavljaet priblizitel'no dva dnja. Chetkie skennogrammy shhitovidnoj

  14. Coincidence scanning with positron-emitting arsenic or copper in the diagnosis of focal intracranial disease; Exploration par coincidences avec l'Arsenic ou le Cuivre Emetteurs de Positrons dans le Diagnostic des Maladies intracraniennes localisees; Raspoznavanie ochagovykh vnutricherepnykh zabolevanij putem podscheta (skanirovaniya) sovpralenij s primeneniem mysh'yaka ili medi, vydelyayushchikh pozitrony; Exploracion por coincidencia con arsenico o cobre emisores de positrones en el diagnostico de enfermedades intracraneanas localizadas

    Energy Technology Data Exchange (ETDEWEB)

    Sweet, William H; Mealey, John Jr; Brownell, Gordon L; Aronow, Saul [Departments of Surgery and Medicine, Harvard Medical School, and Neurosurgical Service and Physics Research Laboratory of Massachusetts General Hospital, Boston, MA (United States)

    1959-07-01

    suficiente para proceder a la reseccion quirurgica, quizas sea esta la contribucion mas importante del metodo hasta la fecha. En cambio, los resultados con tumores subtentoriales fueron menos satisfactorios, pues se fracaso en 23 de 39 casos, es decir en el 59 por ciento. En el grupo de enfermedades benignas, el arsenico permitid localizar 7 de 8 hematomas subdurales, mientras que la exploracion mediante cobre no dio ningun resultado positivo en tres casos. En cuatro casos sobre cinco el empleo del arsenico permitio localizar coagulos intracerebrales diagnosticados. La totalidad de los 10 abscesos estudiados fue diagnosticada mediante el arsenico, y 3 de cada 4 mediante el cobre. En los tres pacientes que sufrian de leucoencefalopatia, la exploracion mediante arsenico indico las zonas principales de desmielinizacion. De 10 pacientes que hablan sido sometidos a un total de 16 exploraciones, y a los que posteriormente se efectuo una craneotomia exploratoria con resultado negative, no hubo mas que dos en los cuales la exploracion (mediante arsenico y cobre respectivamente) habia permitido diagnosticar una anormalidad localizada y bien definida. (author) [Russian] Nastoyashchij doklad posvyashchen podschetu metodom sovpadenij v chelovecheskom organizme parnykh annigilyatsonny kh gamma-luchej, vydelyaemykh pri pozitroniem raspade izotopov medi i mysh'yaka. V nem rassmatrivaets ya biologicheskoe pove denie neorganicheskoj soli mysh'yakovoj i mysh'yakovistoj kisloty ili mednogo versenata, a takzhe rezul'taty ispol'zovaniya veshchestv pri provedenii issledovanij s pomoshch'yu avtomaticheski rabotayushchej apparatury v tselyakh lokalizatsii vnutricherepnykh mass. Radioaktivnost' glavnykh normal'nykh golovnykh tkanej, a takzhe razlichnykh novoobrazovanij , krovyanykh opukholej (gematom), gnojnikov (abstsessov) i zon razrusheniya mielina byla analizirovana metodom biopsii. Pri primenenii mysh'yaka koehffitsient sootnosheniya mezhdu zakhvatom izotopa v mozgovoj opukholi i ego

  15. The Assessment of Radioactive Caesium in Man; Determination du Radiocesium chez l'Homme; 041e 041f 0420 0415 0414 ; Determinacion del Cesio Radiactivo en el Hombre

    Energy Technology Data Exchange (ETDEWEB)

    Rundo, J.; Taylor, B. T. [United Kingdom Atomic Energy Research Establishment, Harwell, Berks. (United Kingdom)

    1964-11-15

    metodov pokazyvaet, chto ispol'zovanie srednego kojefficienta kalibrovki, poluchennogo na fantome, daet rezul'taty s oshibkoj ne bolee {+-}12%dlja obsleduemyh vesom ot 50 do 100 kg. Pri opredelenii soderzhanija radioaktivnogo cezija s pomoshh'ju analiza vydelenij sushhestvujut razlichnye istochniki netochnosti. Period poluvyvedenija menjaetsja u otdel'nyh lic ot 50 do 150 dnej ili bolee, pri srednej velichine okolo 110 dnej. Pojetomu ispol'zovanie srednej velichiny dlja podscheta soderzhanija izotopa v organizme na osnovanii skorosti sutochnogo vydelenija mozhet privesti k oshibochnomu rezul'tatu s faktorom, dostigajushhim 2. Predstavleny jeksperimental'nye dannye, pokazyvajushhie, chto vo mnogih slu~ chajah period poluvyvedenija mozhno opredelit', vychisliv otnoshenie velichin vydelenija s mochoj i jekskrementami. Vlijanie komponentov s korotkim periodom poluraspada pri zaderzhke cezija na opredelenie soderzhanija ego v organizme imeet gorazdo bbl'shee znachenie. Ispol'zovanie pravil'noj velichiny skorosti vydelenija s mochoj, osnovannoj na opredelenii komponentov s dlitel'nom periodom poluraspada, mozhet privesti k pereocenke velichiny soderzhanija pochti v 8 raz pri primenenii jetoj velichiny k opredeleniju soderzhanija cezija v moche, vydelennoj v pervye sutki posle pogloshhenija izotopa. Pereocenka pri issledovanii sutochnyh prob mochi u otdel'nyh lic ne snizhaetsja nizhe 50%v techenie nedeli posle pogloshhenija. Oshibki pri otdelenii kolebanij v raznye dni sostavljajut ne bolee {+-}30%. Otmechajutsja znachitel'nye dnevnye kolebanija skorosti vydelenija cezija s mochoj; umnozhenie na 3 velichiny soderzhanija cezija v 8-chasovoj probe mochi, vydelennoj za den', dlja vychislenija sutochnogo vydelenija vedet k pereocenke skorosti vydelenija ne bolee chem na 30%. Peremennye velichiny soderzhanija cezija-137 v organizme (v mikrokjuri) poluchajutsja za schet umnozhenija kojefficienta Cs{sup 137} (kalij v nanokjuri/g) v moche na 450. Obsuzhdajutsja pogreshnosti pri jetom

  16. Ranges of Iodine and Bromine Isotopes Produced in the Interaction of High-Energy Protons with Uranium; Isotopes de l'Iode et du Brome Produits par l'Interaction de Protons de Haute Energie avec l'Uranium; 041f 0420 041e 0411 0415 0413 0418 0418 0417 041e 0422 041e 041f 041e 0412 0419 041e 0414 0410 0418 0411 0420 041e 041c 0410 , 041f 041e 041b 0423 0427 0415 041d 041d 042b 0425 041f 0420 0418 0412 0417 0410 0418 041c 041e 0414 0415 0419 0421 0422 0412 0418 0418 041f 0420 041e - 0422 041e 041d 041e 0412 0411 041e 041b 042c 0428 041e 0419 042d 041d 0415 0420 0413 0418 0418 0421 0423 0420 0410 041d 041e 041c ; Alcance de los Isotopos del Yodo y del Bromo Producidos en la Interaccion de Protones de Alta Energia con el Uranio

    Energy Technology Data Exchange (ETDEWEB)

    Brandt, R. [CERN, Geneva (Switzerland); Max Planck Institut fuer Kernphysik, Heidelberg, Federal Republic of Germany (Germany)

    1965-07-15

    la produccion de isotopos deficientes en neutrones vuelve a observarse empleando altas energias de bombardeo. El autor centra su estudio en esos isotopos deficientes en neutrones, que practicamente se producen solo a niveles superiores a 1 GeV; a energias de bombardeo mas elevadas, su alcance esta limitado aproximada mente a la mitad del alcance de los productos de fision normales, lo que indica que se forman en virtud de un proceso distinto del de fision. El autor examina estas conclus iones teniendo en cuenta modelosde 'espalacion ' y de ' fragmentacion '. definiendo de nuevo estos dos terminos. (author) [Russian] Obychnye jeksperimenty po probegam s ispol'zovaniem tolstoj uranovoj fol'gi vmeste s aljuminievymi lovushkami i dozimetrami provodjatsja na dvuh uskoriteljah CERN s protonami, imejushhimi jenergii 0,55 Bjev i 18,2 Bjev. Iod (ili brom) vydeljadtsja himicheshim putem i razdeljaetsja v separatore radioizotopov v CERN. V rezul'tate poluchajut obrazcy bez nositelja, soderzhashhie po sushhestvu tol'ko odin chistyj radioaktivnyj izotop. Opredeljaetsja takzhe vyhod himicheskih produktov. Analiz dannyh pozvoljaet poluchit' neposredstvenno probeg dlja kazhdogo izotopa v urane. Vse izotopy joda imejut odin i tot zhe probeg pri jenergii protonov 0,55 Bjev, t.e. oni vse obrazujutsja v processe delenija. Ranee bylo izvestno, chto izotopy Joda s izbytkom nejtronov imejut priblizitel'no odin i tot zhe probeg, nezavisimo ot togo,prevyshaet li jenergija protonov 1 Bjev ili ona nizhe jetogo urovnja, a takzhe, chto izotopy joda s nedostatkom nejtronov dajut rezkoe sokrashhenie, priblizitel'no na polovinu, pri uvelichenii jenergii protonov svyshe 1 Bjev. Pokazyvaetsja, chto jeto sokrashhenie probega proishodit dovol'no vnezapno, privodja k skachku na krivoj zavisimosti probega ot massy izotopa joda. Izotopy s nedostatkom nejtronov, imeja sokrashhennyj probeg pri jenergii protonov svyshe I Bjev, javljajutsja temi zhe samymi izotopami, v otnoshenii kotoryh nabljudalos' sil

  17. The adsorption of hydrogen on a molecular sieve at -196{sup o}C and the observation of an isotope effect; Adsorption d'hydrogene sur un tamis moleculaire a -196{sup o}C et observation d'un effet isotopique; Absorbtsiya vodoroda na molekulyarnom fil'tre pri -196{sup o} i nablyudenie rezul'tatov dejstviya izotopov; Adsorcion de hidrogeno en un tamiz molecular a -196{sup o}C y observacion de un efecto isotopico

    Energy Technology Data Exchange (ETDEWEB)

    Duncombe, W G [Wellcome Research Laboratories, Beckenham, Kent (United Kingdom)

    1962-03-15

    adsorbio en el tamiz molecular cerca del 99 % del hidrogeno inicial antes de comenzar la desorcion por bombeo. Por lo tanto, parece probable que el considerable fraccionamiento observado tenga lugar principalmente durante la desorcion y que el efecto carezca de importancia cuando el tamiz se emplea para manipular pequenos volumenes de isotopos del hidrogeno ya que, por lo general, la desorcion total se efectuara por calentamiento. (author) [Russian] Ispytyvalsya molekulyarnyj fil'tr Linde 4 A v kachestve vozmozhnogo sredstva obrashcheniya s nebol'shimi ob{sup e}mami izotopov vodoroda v vakuume, vmesto primenyayushchegosya v nastoyashchee vremya nasosa Toiplera. Davlenie ravnovesiya (P) izmeryaetsya razlichnymi ob{sup e}mami (V) vodoroda, absorbiruemogo odnim grammom fil'tra pri temperature -196{sup o}. EHksperimenty s aktivirovannym drevesnym uglem pokazyvayut preimushchestvo fil'tra kak absorbenta vodoroda. Odin gramm fil'tra v sisteme s ob{sup e}mom v 500 ml absorbiruet okolo 97 % odnogo ml obraztsa vodoroda. Absorbtsiya neznachitel'na pri temperature -78{sup o}, i desorbtsiya yavlyaetsya kolichestvennoj i b'kpro protekaet pri komnatnoj temperature. Vozmozhnost' rezul'tatov dejstviya izotopa izuchalas' putem absorbirovaniya izmeryaemykh ob{sup e}mov tritiya (5 millikyuri/mol') pri ravnomernom davlenii okolo 5 mm, pri ehtom proiskhodilo vykachivanie sistemy v periode do 15 minut i izmerenie ob{sup e}ma ostatochnogo vodoroda. Poslednij prevrashchalsya kolichestvenno v vodu, zatem v butan i gaz. Udel'naya aktivnost' byla vsegda vyshe, chem aktivnost' tritiya, kotoryj prokhodil 10 tsiklov absorbtsii i desorbtsii bez promezhutochnogo vykachivaniya s tem, chtoby ne bylo nikakikh chistykh poter' gaza. EHto imelo takuyu zhe udel'nuyu aktivnost', kak u neobrabotannogo tritiya, vzyatogo iz rezervnoj kolby. Bylo obnaruzheno, chto logarifm (ostatochnyj ob{sup e}m/nachal'nyj ob{sup e}m) proportsionalen 1/logarifm (ostatochnaya udel'naya aktivnost'/ nachal'naya udel'naya aktivnost') v

  18. Half-Life Studies of Radiocaesium in Humans; Etudes sur la Periode de Radiocesium chez l'Homme; 0418 0421 0421 041b 0415 0414 ; Estudio sobre el Periodo Biologico del Radiocesio en el Hombre

    Energy Technology Data Exchange (ETDEWEB)

    Naversten, Y.; Liden, K. [Radiation Physics Department, University of Lund (Sweden)

    1964-11-15

    estos estudios, sobre todo en lo que respecta a la velocidad de eliminacion del cesio, es decir, al periodo biologico y a su variacion segun el sexo y la edad. Por lo general, los periodos biologicos determinados experimentalmente oscilan entre 30 y 90 d. (author) [Russian] Izuchalas zaderzhka cezija-137 u ljudej pri razlichnyh obstojatel'stvah. Dvum vzroslym muzhchinam vvodili vnutrivenno malye kolichestva cezija-137. Pacienty nahodilis' pod nabljudeniem 300 dnej, v techenie kotoryh proizvodilis' chastye izmerenija radio aktivnosti vsego organizma.i sbor vydelenij v nachal'nom periode. Stepen' zaderzhki izotopa snizhalas' kak summa dvuh jeksponencial'nyh velichin. Naibolee medlenno izmenjajushhajasja velichina snizhalas' s periodom poluvyvedenija okolo 75 dnej. Olin iz pacientov poluchal cezij-137 vnutr' 2 goda spustja,prichem nabljudalsja tot zhe tip vydelenija, kak i posle vnutrivennogo vvedenija. Skorost' vydelenija cezija-137 izuchalas' takzhe drugim sposobom u bol'shoj gruppy muzhchin, zhenshhin i detej putem sravnenija dannyh issledovanija diety. Pri obsledovanii gruppy iz 10 dobrovol'cev, izmenivshih svoju dietu, okazalos' vozmozhnym rasschitat' srednjuju skorost' vydelenija na osnovanii izmerenija radioaktivnosti vsego organizma s intervalom v 6 nedel'. Vydelenija opredeljali takzhe u 2-h chelovek posle priema vnutr' cezija-137. Predstavleny podrobnye dannye jetih issledovanij, v osobennosti v otnoshenii skorosti vydelenija cezija, t.e. perioda ego poluvyvedenija i ego variacij v zavisimosti ot pola i vozrasta. V srednem byli polucheny sroki poluvyvedenija ot 30 do 90 dnej. (author)

  19. Production of Short-Lived Radionuclides at the Hahn-Meitner Institute in West Berlin; Production de Radionuclides a Courte Periode a l'Institut Hahn-Meitner de Berlin-Ouest; ПРОИЗВОДСТВО КОРОТКОЖИВУЩИХ РАДИОИЗОТОПОВ В ИНСТИТУТЕ ХАНА-МАЙТНЕРА В ЗАПАДНОМ БЕРЛИНЕ; Produccion de Radionuclidos de Periodo Corto en el Instituto Hahn-Meitner de Berlin Occidental

    Energy Technology Data Exchange (ETDEWEB)

    Felix, F. W.; Pirrwitz, D.; Szabo de Bucs, E. [Hahn - Meitner-Institut fuer Kern Forschung, Berlin, Federal Republic of Germany (Germany)

    1963-03-15

    la capadidad de produccion del citado Instituto. (author) [Russian] Nachinaja s I960 goda Institut po jdernym issledovanijam Hana-Majtnera proizvodit korotkozhivushhie radioizotopy dlja medicinskih i nauchnyh celej dlja rajona Zapadnogo Berlina. V nastojashhee vremja proizvodjatsja izotopy, primenjaemye obychno v medicine, takie, kak Na{sup 25}, K{sup 42}, Au{sup 198}, a takzhe nekotorye menee rasprostranennye, kak Cu{sup 64}, Zn{sup 69m} i F{sup 18}. Na{sup 24} i K{sup 42} byli polucheny v rezul'tate nejtronnogo obluchenija hloridov i razoslany posle kalibrovki v vide tverdyh veshhestv. Au1 Registered-Sign 8, obluchennyj v forme metalla, upotrebljaetsja dlja implantacii pri lechenii raka. F{sup 19} poluchaetsja v rezul'tate reakcii O{sup 16} (t, n) i obluchenija LiNO{sub 3} Otdelenie F{sup 16} pri pomoshhi ionnogo obmena dalo luchshie rezul'taty, chem opisyvaemye obychno v literature metody. Dlja proizvodstva Cu{sup 64} i Zn{sup 89m} byl razrabotan special'nyj metod jelektroliza dlja jekstragirovanija izotopov, poluchennyh pri pomoshhi reakcii Scilard-Hal'mersa s ftalocianinami. Oba jeti izotopa nahodjat primenenie v medicinskoj diagnostike. Privodjatsja podrobnye dannye otnositel'no oborudovanija i tehniki obluchenija, sposobov proizvodstva i apparatury, kalibrovki poluchennyh izotopov i proizvoditel'noj sposobnosti. (author)

  20. Mass dependence of intermetallic diffusion; Influence de la masse sur la diffusion intermetallique; Zavisimost' massy intermetallicheskoj diffuzii; Influencia de la masa sobre la difusion entre metales

    Energy Technology Data Exchange (ETDEWEB)

    Lazarus, D [Department of Physics, University of Illinois, Urbana, IL (United States)

    1962-01-15

    disolvente. El autor analiza tambien la influencia ejercida por la temperatura sobre ese efecto. (author) [Russian] Byli provedeny ehksperimenty dlya opredeleniya spetsificheskogo ehffekta izotopnykh mass na stepen' intermetallicheskoj diffuzii dlya togo, chtoby proverit' primenenie teorii ob{sup e}ma absolyutnoj reaktsii k protsessu diffuzii, a takzhe vychisleniya Bardina i KHerringa v otnoshenii korrelyatsii mezhdu izotopnym indikatorom i atomnymi perekhodami v rastvoritele. Primenyayutsya metody tochnykh sechenij s ispol'zovaniem izotopnykh indikatorov zheleza-55 i zheleza-59 v chistykh serebryanykh i mednykh odnokristallicheskikh obraztsakh. Dlya izmereniya nebol'shoj zavisimosti massy pri provedenii opyta trebuetsya bol'shaya tochnost'. Poskol'ku oba izotopa zheleza imeyut sovershenno razlichnye skhemy raspada, to tochnoe differentsirovannoe izmerenie aktivnosti mozhet byt' osushchestvleno s pomoshch'yu poglotitelej iz zolota i berilliya posle radiokhimicheskogo otdeleniya izotopnykh indikatorov ot osnovnogo materiala. Rezul'taty pokazyvayut, chto otnositel'naya skorost' diffuzii dvukh dannykh izotopov yavlyaetsya znachitel'no men'shej po sravneniyu s obychno ozhidaemoj skorost'yu blagodarya ili smeshcheniyu ot svoego polozheniya ravnovesiya vo vremya perekhodov v ehlementarnoj diffuzii ili sil'noj korrelyatsii mezhdu atomnymi perekhodami rastvoryaemogo veshchestva i rastvoritelya. Takzhe rassmatrivaetsya zavisimost' ehffekta ot temperatury. (author)

  1. The isotope-dilution method of fluorine microestimation; Microdosage du fluor pur dilution isotopique; Mikroopredelenie ftora no metodu razbavleniya izotopov; Microvaloracion del fluor por dilucion isotopica

    Energy Technology Data Exchange (ETDEWEB)

    Kudahl, J N; Fremlin, J H; Hardwick, J L [Department of Physics, University of Birmingham (United Kingdom)

    1962-01-15

    des matieres organiques peuvent etre reduites en cendres en toute securite si des ions de calcium ou de magnesium sont presents. La precision de la methode ne depend pas de la concentration du fluorure jusqu'a concurrence de valeurs representant une fraction d'une ppm. (author) [Spanish] El vidrio adsorbe los iones fluoruro de las soluciones acidas, y si estas soluciones contienen menos de 100 ppm de fluor, la cantidad adsorbida varia muy regularmente en funcion de la concentracion. El metodo empleado por los autores consiste en anadir a cada uno de los integrantes ele una serie de soluciones acidas, que pueden contener unos miligramos, o menos, de fluoruro, un cierto volumen de una solucion del isotopo inestable {sup 18}F libre de portador. Si estas soluciones se aplican a un area determinada de vidrio, parte del {sup 18}F es adsorbida y puede ser fijada elevando el pH una vez alcanzado el equilibrio. La radiactividad del vidrio constituye una medida de la cantidad total de fluoruro presente sobre el vidrio, y puede utilizarse para trazar una isotermia de adsorcion de la cual se puede deducir el contenido en fluor de una solucion desconocida de la serie. Luego de estudiar los efectos del pH de la presencia de iones calcio y fosfato, los autores ban comprobado que las sustancias organicas pueden ser calcinadas sin peligro alguno siempre que se encuentreu presentes iones calcio o magnesio. La precision del metodo no depende de la concentracion de fluoruro siempre que esta sea inferior a 1 ppm. (author) [Russian] Ion ftora iz kislotnogo rastvora adsorbiruetsya na steklo, i dlya rastvorov, soderzhashchikh menee 100 chastej ftora na million, adsorbiruemoe kolichestvo izmenyaetsya ochen' regulyarno v zavisimosti ot kontsentratsii. K kazhdomu iz kislotnykh rastvorov ftora v dannoj serii, ne prevyshayushchikh po vesu neskol'kikh milligrammov, a to i men'she, dobavlyaetsya nekotoryj ob{sup e}m svobodnogo ot nositelej rastvora neustojchivogo izotopa F{sup 18}. Esli rastvory

  2. Uptake, retention and excretion of strontium in man; Assimilation, retention et excretion du strontium chez l'homme; Pogloshchenie, zaderzhka i vydelenie strontsiya organizmom cheloveka; Absorcion, retencion y excrecion del estroncio en el hombre

    Energy Technology Data Exchange (ETDEWEB)

    Harrison, G. E. [Radiobiological Research Unit, Medical Research Council, Harwell (United Kingdom)

    1963-02-15

    estroncio en el esqueleto y sugiere que existen por lo menos tres grados de fijacion del estroncio radiactivo en los huesos. Estudia particularmente la retencion despues de varios meses de aplicada la dosis y la relacion existente entre esta retencion y la dosis de radiacion de {sup 90}Sr recibida por el esqueleto. Propone por ultimo una formula para evaluar la retencion en el organismo de una dosis de estroncio radiactivo a partir del valor de la radiactividad excretada con la orina. (author) [Russian] Obsuzhdaetsya vopros o vsasyvanii strontsiya iz zheludochno-kishechnogo trakta v svyazi s dietoj i razlichnymi komponentami khlebnomolochnoj diety. Privodyatsya rezul'taty, poluchennye pri ispol'zovanii kompleksnykh soedinenij, i diety s vysokim soderzhaniem kal'tsiya dlya umen'sheniya pogloshcheniya strontsiya. Obsutdaetsya sootnoshenie strontsiya i kal'tsiya v razlichnykh chastyakh tela u vzroslogo cheloveka. Privodyatsya rezul'taty nedavnikh ehksperimental'nykh issledovanij, provedennykh u zdorovykh lyudej na postoyannoj diete, pri ehtom osoboe vnimanie udelyaetsya vydeleniyu s mochoj i zaderzhke strontsiya-85, soderzhashchegosya v ehksperimental'noj diete. Opredelyalos' takzhe ehndogennoe vydelenie s ehkskrementami. Ehti dannye sravnivayutsya s rezul'tatami, poluchennymi pri odnokratnom vnutrivennom vvedenii radioaktivnogo strontsiya. Vo vsekh sluchayakh uderzhanie strontsiya opoedelyalos' izmereniem radioaktivnosti vsego organizma s pomoshch'yu amplitudnogo analizatora impul'sov. Analiziruyutsya prichiny ehaderkhki strontsiya a' skelete i postiliruetsya, chto imeyutsya, po krajnej meretri stepeni svyazi radioaktivnogo strontsiya s kostyami. Obsukhdaetsya, v chastnosti, zaderkhka izotopa v techenie neskol'kikh mesyatsev posle ego vvedeniya, a tayue svyaz' ehtoj zaderzhki s dozoj oblucheniya, poluchaemoj skeletom ot strontsiya-90. Predlagaetsya formula dlya opredeleniya uderzhaniya organizmom radioaktivnoj dozy strontsiya v zavisimosti ot radioaktivnosti, vydelyaemoj s

  3. A modification of the method for determining current efficiency of aluminium electrolytic cells; Modification de la methode permettant de determiner le rendement des cuves dans la production d'aluminium par electrolyse; Izmenenie metoda opredeleniya ehffektivnosti toka v alyuminievykh ehlektroliticheskikh bakakh; Modificacion del metodo para determinar el rendimiento de las celdas utilizadas en la produccion de aluminio por electrolisis

    Energy Technology Data Exchange (ETDEWEB)

    Pradzynski, A [Institute of Basic Technical Problems, Polish Academy of Sciences. Warsaw (Poland); Orman, Z [Institute of Nonferrous Metals, Gliwice (Poland)

    1962-01-15

    alyuminievykh pechakh, opisannyj vpervye REMPELEM i dr., byl usovershenstvovan BOZUKI i dr. pri pomoshchi ispol'zovaniya radioaktivnogo izotopa zolota Au{sup 198}. Pri provedenii upomyanutogo issledovaniya byli izgotovleny obraztsy splavov alyuminiya s zolotom Au{sup 198}, i proby ehtikh obraztsov s vysokoj udel'noj aktivnost'yu byli izmereny pri pomoshchi schetchika Gejgera-Myullera so svintsovym poglotitelem, vstavlennym mezhdu schetchikom i proboj. Udel'naya aktivnost' obraztsa splava byla izmerena posle razbavleniya ego opredelennym kolichestvom chistogo alyuminiya. Takim obrazom proby razbavlennogo splava i proby, vzyatye iz ehlektroliticheskogo baka, imeli udel'nuyu aktivnost' togo zhe poryadka velichiny i mogli izmeryat'sya bez vsyakogo poglotitelya. Dlya togo, chtoby oblegchit' primenenie ehtogo metoda na alyuminievom zavode i vo izbezhanie vsyakikh ogranichenij i opasnosti, svyazannykh s obrashcheniem s otkrytymi radioaktivnymi istochnikami vne osobykh laboratorij, prednaznachennykh dlya issledovaniya radioaktivnykh izotopov, byl ispol'zovan radioaktivatsionnyj analiz. K obraztsu splava, a takzhe i v nakhodyashchuyusya v ehlektroliticheskom bake plavil'nuyu vannu bylo dobavleno neaktivirovannoe zoloto. Kontsentratsiya zolota kak v obraztsakh splava, tak i v plavil'noj smesi byla zatem izmerena posle oblucheniya prob v yadernom reaktore. (author)

  4. Advanced epithermal thorium reactor (AETR) physics; Physique d'un reacteur au thorium, a neutrons epithermiques, de type perfectionne (AETR); Fizika usovershenstvovannog o nadteplovogo torievogo reaktora; Fisica del reactor epitermico de tipo avanzado, alimentado con torio (AETR)

    Energy Technology Data Exchange (ETDEWEB)

    Campise, A. V. [Atomics International, Canoga Park, CA (United States)

    1962-03-15

    del {sup 233}Pa y de isotopos del uranio sobre el balance neutronico relativo y se evalua la probable razon de reproduccion y las caracteristicas de combustion teniendo en cuenta la imprecision en el conocimiento de las secciones eficaces nucleares. (author) [Russian] Rassmatrivayuts ya printsipy konstruirovani ya usovershenstvovannog o nadteplovogo torievogo reaktora s uchetom sushchestvuyushchej teorii yadernykh parametrov i potentsial'nogo poleznogo ispol'zovaniya nejtronov. Byl izuchen ehffekt rezonansnogo zakhvata toriya v sistemakhs grafitovym zamedlitelem dlya nejtronov s ehnergiyami ot 0,10 do 100 kehv. Ispol'zuyutsya formuly uzkogo rezonansa i shirokogo rezonansa v tselyakh polucheniya zavisimogo ot temperatury ehffektivnogo rezo- nansnogo integrala torievogo sterzhnya, kotoryj vyrazhaetsya v vide ehkvivalentnykh mnogogruppovykh sechenij. Neobkhodimost' v poluchenii yadernykh dannykh v oblasti promezhutochnykh ehnergij privela k sozdaniyu proekta i konstruktsii kriticheskoj sborki. Yadernyj proekt ehtoj sborki podcherkivaet vazhnost' dannykh poperechnykh sechenij i teoreticheskoj interpretatsii ehksperimental'nykh rezul'tatov, imeyushchikh otnoshenie k usovershenstvovannom u nadteplovomu torievomu reaktoru. Tochnost' analiticheskikh metodov byla podtverzhdena pri analize ehksperimental'nykh rezul'tatov, poluchennykh na reaktore nulevoj moshchnosti ZPR-III. Provodyatsya sravneniya trekh konfiguratsij teploperedachi s ispol'zovaniem udvoennogo vremeni v kachestve optimal'nogo parametra. EHffekt proizvodstva izotopa protaktiniya-233 i urana pri otnositel'no poleznom ispol'zovanii nejtronov, vozmozhnye koehffitsienty vosproizvodstva i kharakteristiki vygoraniya otsenivayutsya v svyazi s netochnostyami v yadernykh poperechnykh secheniyakh. (author)

  5. The Estimation of Internal Contamination with Uranium from Urine Analysis Results; Evaluation de la Contamination Interne par l'Uranium a Partir des Resultats de l'Analyse d'Urines; 041e 0426 0414 ; Evaluacion de la Contaminacion Interna con Uranio a Partir de los Resultados del Analisis de Orina

    Energy Technology Data Exchange (ETDEWEB)

    Jackson, S. [Authority Health and Safety Branch, Radiological Protection Division, United Kingdom Atomic Energy Authority, Harwell, Berks. (United Kingdom)

    1964-11-15

    ' kolichestvo osevshego v organizme urana, chem obshhee kolichestvo pogloshhennogo izotopa. Jetogo mozhno dobit'sja putem issledovanija obrazcov, vzjatyh ne srazu posle obluchenija, a cherez nekotoroe vremja. Prakticheski obrazcy, vzjatye u ljudej posle vozvrashhenija iz otpuska, javljajutsja ochevidno nailuchshim materialom, no mozhet byt sleduet vzjat' obrazcy posle vyhodnogo dnja, v techenie kotorogo obluchenie otsutstvovalo. (author)

  6. Determination of Fallout Radionuclides in Environmental Samples by Gamma-Ray Spectrometry; Mesure Spectrometrique Gamma des Radionucleides de Retombee Presents dans des Echantillons du Millieu; Opredelenie radioizotopov radioaktivnykh osadkov v probakh iz okruzhayushchej sredy pri pomoshchi spektrometrii gamma-luchej; Determinacion, por Espectrometria Gamma, de los Radionuclidos de Precipitaciones en Muestras del Medio Ambiente

    Energy Technology Data Exchange (ETDEWEB)

    Ward, G. M.; Johnson, J. E.; Wilson, D. W. [Department of Animal Science, Colorado State University, Fort Collins, CO (United States)

    1965-10-15

    neposredstvennoe opredelenie cezija-137 i drugih radioizotopov, to hranenie prob do raspada cirkonija-95 i niobija-95 (T1/2 - 65 sutok) i rutenija-103 (T1/2 - 40 sutok) daet vozmozhnost' opoznat' fotopiki ostavshihsja radioizotopov. Cezij-137 i marganec-54 mogut byt' otdeleny himicheskim sposobom putem rastvorenija prob v koncentrirovannom rastvore NaOH (cezij-137 iz radio- aktivnyh osadkov rastvorjaetsja polnost'ju tol'ko v sil'nyh shhelochnyh rastvorah) i fil'tro- vanija, chto daet vozmozhnost' udalit' okolo 95% cirkonija-95 i niobija-95. Vymyvanie koncentratov dozhdevoj vody iz kolonki pri pomoshhi odnomoljarnoj NH4 N03 kolichestvenno vydeljaet cezij-137 i jeffektivnym obrazom otdeljaet aktivnost' cirkonija-95 i niobija-95 ot aktivnosti marganca-54. Posle togo, kak vse fotopiki oyli vyjavleny lioo posredstvom raspada, lioo po- sredstvom himicheskogo otdelenija, dal'nejshee kolichestvennoe opredelenie kazhdogo radio- izotopa stanovitsja vozmozhnym posredstvom kalibrovki pri pomoshhi k a zh d o g o izotopa i podscheta komptonovskogo jeffekta kazhdogo iz nih. Poluchennye uravnenija byli resheny na schetno-reshajushhem ustrojstve IBM 1620, i byla sostavlena programma dlja razreshenija problemy koncentracii kazhdogo iz devjati upomjanutyh vyshe radioizotopov. Ta zhe samaja programma byla ispol'zovana dlja opredelenija soderzhanija cezija-137i kalija-40 v moloke, mjase i moche, chto predstavljaetsja bolee prostym sposobom i osushhestvimo s men'shimi po- greshnostjami. (author)

  7. Transmutation doping and recoil effects in semiconductors exposed to thermal neutrons; Transmutations provoquees et effets de recul dans les semi-conducteurs exposes aux neutrons thermiques; Prisadka i sdacha v rezul'tate prevrashcheniya poluprovodnikov pod dejstviem teplovykh nejtronov; Impurificacion por transmutacion y efectos de retroceso en los semiconductores expuestos a neutrones termicos

    Energy Technology Data Exchange (ETDEWEB)

    Crawford, Jr, J H; Cleland, J W [Solid State Division, Oak Ridge National Laboratory, Oak Ridge, TN (United States)

    1962-01-15

    ({sup 71}Ga); una correcta eleccion de la exposicion permite por tanto disminuir la concentracion de electrones en el germanio de tipo n hasta valores muy bajos, o transformar el germanio de tipo n en germanio de tipo p. Afortunadamente, el periodo de semidesintegracion del nuclido que da origen al {sup 71}Ga es largo; ello permite observar en detalle el curso de la ''valoracion radiactiva'' por medicion del coeficiente de Hall y de la comductividad. Los experimentos demuestran tambien que los defectos que producen en la red cristalina los retrocesos de nucleos causados por la emision gamma consecutiva a la captura neutronica eliminan aproximadamente un electron por cada neutron capturado. El recocido a unos 450 Degree-Sign C hace que los atomos desplazados vuelvan a los sitios que les corresponden en la red cristalina. Tambien se han observado efectos del retroceso en el silicio; cada captura da lugar a la eliminacion de, aproximadamente, dos portadores de carga. Los autores analizaran las deducciones a que llevan estos resultados y los obtenidos con el germanio, basandose en los espectros de rayos gamma de captura. En el caso del antimoniuro de indio, los rayos gamma de captura emitidos por el {sup 115}In no bastan para desplazar un numero grande de nucleos, de modo que el efecto principal es la formacion de {sup 116}Sn, que es un donor cuando sustituye a un atomo de indio en una red cristalina de este elemento. La impurificacion por transmutacion nuclear ofrece una posibilidad de estudiar numerosos semiconductores compuestos en los que resulta dificil introducir impurezas por procomientos quimicos. (author) [Russian] Byli provedeny podrobnye issledovaniya vozdejstviya teplovykh nejtronov na germanij. Iz pyati izotopov tri izotopa prevrashchayutsya v khimicheskie primesi, vykhod kotorykh, v chisle atomov na 100 zakhvatov nejtronov, i ikh periody poluraspada predstavlyayutsya v sleduyushchem vide: Ga{sup 71} - 30,4, 11,4 dnya; As{sup 75} - 9,8, 82 min; Se{sup 77} - 1

  8. Liquid Scintillation Detection of Tritium and other Radioisotopes in Insoluble or Quenching Organic Samples; Detection par compteur a scintillations a liquides du tritium et des autres radioelements contenus dans des echantillons organiques insolubles ou coupeurs; Obnaruzhenie tritiya metodom zhidkostnoj stsintillyatsii v nerastvorimykh ili sposo'nykh gasit' izluchenie organicheskikh o'raztsakh; Deteccion del tritio u otros radioisotopos por centelleo liquido en muestras organicas insolubles o que provocan extincion

    Energy Technology Data Exchange (ETDEWEB)

    Eastham, J F; Westbrook, H L; Gonzales, D [University of Tennessee, Knoxville, TN (United States)

    1962-01-15

    las sustancias organicas, a saber, el recuento por centelleos de liquidos. Estos inconvenientes, que son la extincion del centelleo producida por. muchas muestras organicas y la escasa solubilidad de otras, son particularmente frecuentes en las sustancias de importancia biologica. El procedimiento ideado por los autores consiste en lo siguiente: combustion de la muestra, envuelta en papel de filtro, en un matraz lleno de oxigeno; disolucion de los productos de combustion en un disolvente adecuado que se introduce en el matraz antes de la combustion, y recuento por centelleo de la actividad de la solucion. Ademas de superar los inconvenientes mencionados, este procedimiento posee otras ventajas: eficacia con muestras de actividades muy diversas (algunas, tan baja como 1{mu}c/M), precision (tan elevada como la de cualquier otro metodo general de radioanalisis del {sup 3}H) y posibilidad de aplicarlo a otros emisores beta blandos ({sup 14}C y {sup 35}S). Con un espectrometro de centelleo y merced al procedimiento ideado, es posible efectuar un radioanalisis diferencial de muestras marcadas con tres indicadores ({sup 3}H, {sup 14}C y {sup 35}S). Los autores describen con detalle las tecnicas y los sistemas de disolventes utilizados. Asimismo, exponen los resultados obtenidos en el analisis de sustancias que provocan extincion, como 2,4- dinitrofenilhidrazona s y colorantes de tiazol, y de sustancias insolubles, como proteinas e hidratos de carbono. Estudian la aplicacion de estas tecnicas al analisis de los efectos isotopicos {sup 1}H/{sup 3}H en ciertas reacciones de reduccion. (author) [Russian] CHtoby oblegchit' izuchenie vliyaniya izotopa H{sup 1}/H{sup 3} na vosstanovlenie organicheskikh soedinenij neobkhodimo bylo razrabotat' protsedury dlya preodoleniya dvukh osnovnykh ogranichenij v naibolee udobnom obshchem metode izmereniya radioaktivnosti organicheskikh veshchestv posredstvom zhidkostnogo stsintillyatora . EHti ogranicheniya, kotorymi yavlyayutsya

  9. The Determination of Components of Radioactive Decay Mixtures by Computer Analysis of Count-Rate Data; Determination des Composants de Melanges Radioactifs en Decroissance par Analyse a l'Ordinateur des Resultats du Comptage; Opredelenie komponentov smesej radioaktivnogo raspada posredstvom analiza dannykh skorostej scheta s pomoshch'yu schetno-reshayushchego ustrojstva; Determinacion de los Componentes de Mezclas Radiactivas por Analisis de los Datos de Recuento Mediante Calculadoras

    Energy Technology Data Exchange (ETDEWEB)

    Airman, W. D.F.; Tyler, S. A.; Dipertand, M. H.; Sedlet, J. [Argonne National Laboratory, Argonne, IL (United States)

    1965-10-15

    izmenjaetsja znachitel'nym obrazom za period vremeni nabljudenija, libo v rezul'tate neposredstvennogo raspada, libo vsledstvie narastanija produktov raspada. Dlja kazhdoj novoj smesi predstavljaetsja vozmozhnym predskazat' sostav vozmozhnyh komponentov na osnovanii takih soobrazhenij, kak proishozhdenie i posledujushhaja jevoljucija smesi, harakter himii otdelenija i metod ili metody scheta. Esli takogo roda soobrazhenija primenjajutsja nadlezhashhim obrazom, to sostav vozmozhnyh komponentov vkljuchit vse dejstvitel'nye komponenty smesi. V takom sluchae mozhno sostavit' nadlezhashhie uravnenija narastanija i raspada i reshit' ih odnovremenno dlja poluchenija kazhdogo komponenta, ili zhe smes' mozhet byt' razlozhena na sostavnye chasti graficheski putem jekstrapoljacii linejnyh otrezkov krivoj obshhego raspada i narastanija. Odnako v sluchae bol'shogo chisla komponentov, esli rech' idet o kompleksnyh shemah raspada, jeti dva metoda libo okazyvajutsja nepriemlemymi, libo ne predstavljaetsja vozmozhnym opredelit' velichiny pogreshnostej, svjazannyh s vychislenijami. Otbor komponentov raspada po metodu naimen'shih kvadratov daet luchshuju ocenku, chem samo po sebe odnovremennoe reshenie uravnenij. Pojetomu na osnovanii metoda naimen'shih kvadratov byla vyrabotana programma po fortranu dlja schetno-reshajushhego ustrojstva (oboznachennaja po kodu {sup K}ORD{sup )}, kotoraja razreshaet sledujushhuju obshhuju problemu: zadajutsja momenty vremeni i otschety za edinicu vremeni dlja proby, vozmozhnye ishodnye radioizo- ' topy i shemy ih raspada, a takzhe vse sootvetstvujushhie konstanty raspada i jeffektivnosti obnaruzhenija; trebuetsja podschitat' kolichestvo kazhdogo ishodnogo izotopa, dejstvitel'no prisutstvujushhego v zaranee opredelennoe nulevoe vremja. V dopolnenie k jetomu programma daet kolichestvo ishodnyh i dochernih produktov v ljuboj moment registracii dannyh. Ispol'zovannaja pervonachal'no dlja bioanalizov i dlja analiza vzjatyh iz okruzhajushhej sredy prob, jeta programma

  10. Moessbauer Effect Study of the Isomeric De-Excitation in Sn{sup 119m}; Etude, par Effet Moessbauer, de la Desexcitation Isomerique dans {sup 119m}Sn; 0418 0417 0423 0427 0415 041d 0418 0415 041c 0415 0421 0421 0411 0410 0423 0415 0420 0421 041a 041e 0413 041e 042d 0424 0424 0415 041a 0422 0410 041f 0420 0418 0418 0417 041e 041c 0415 0420 041d 041e 041c 0421 041d 042f 0422 0418 0418 0412 041e 0417 0411 0423 0416 0414 0415 041d 0418 042f 0412 041e 041b 041e 0412 0415 -119{sup m}; Estudio de la Desexcitacion Isomerica del {sup 119m}Sn Mediante el Efecto Moessbauer

    Energy Technology Data Exchange (ETDEWEB)

    Herber, R. H.; Stoeckler, H. A. [School of Chemistry, Rutgers, State University, New Brunswick, NJ (United States)

    1965-04-15

    aproximacion no relativistica) la energia de retroceso ha de ser inferior a Tilde-Operator 0,3 keV ( Tilde-Operator 7 kcal/mol), valor que es considerablemente menor que las energias de enlace quimico que entran en juego. (author) [Russian] Kak i v sluchae K-zahvata i gamma-izluchenija ego raspada kobal'ta-57 himicheskie posledstvija izomernogo raspada olova-119{sup m} mogut byt' izucheny po spektroskopicheskomu metodu Messbauera. Snjatie vozbuzhdenija s 245-dnevnogo izotopa v sostojanii i/2 soprovozhdaetsja jemissiej kaskadnogo gamma-izluchenija v 65,3kjev(M4) i 23,8kjev(M1-E2). Po metodu Mess''auera mogut byt' izucheny tri glavnyh himicheskih jeffekta jadernyh prevrashhenij, a imenno: a) posledstvija reakcii Sn{sup 118} (n, {gamma})Sn{sup 119m} i jeffekty soputstvujushhego gamma-izluchenija pri obluchenii v reaktore; '') dejstvie otdachi, soprovozhdajushhej raspad M4 i s) dejstvie vnutrennej konversii raspada M4. Jeti jeffekty byli izucheny na dvuokisi olova, metallicheskom (serom) olove i na tetrafenile olova, kazhdyj iz kotoryh byl markirovan izotopom olova-119{sup m}. V Sn{sup 119m}O{sub 2} ni vozdejstvie gamma-radiacii pri obluchenii v reaktore, ni jemissija (i vnutrennjaja konversija) radiacii v 65,3 kjev ne privodjat k zametnym izmenenijam formy ili polozhenija linii rezonansa. Jeto nabljudenie rezko otlichaetsja ot togo, chto proishodit v analogichnyh uslovijah pri raspade (K-jeahvate i gamma-izluchenii) Co{sup 57} O. V oboih sluchajah izvestny dva sostojanija okislenija metallicheskoj okisi [sootvetstvenno Fe (II), Fe(III) i Sn (I), Sn(IV)], no tol'ko v sluchae Co{sup 57} O, v rezul'tate predshestvovavshego jadernogo prevrashhenija, nabljudalos' nalichie oboih sostojanij. Analogichnye otricatel'nye rezul'taty poluchajutsja dlja metallicheskogo (serogo) slova, chto soglasuetsja s nabljudenijami nad kobal'tom-57, rassejannym v metallicheskom zheleze i ispol'zovannom v kachestve Messbauerovskogo istochnika. Odnako, kak i v sluchae mechennogo kobal'tom-57

  11. Nuclear geophysics in prospecting for ore and coal deposits; Geophysique nucleaire et prospection des gisements de charbon et autres mineraux; Yadernaya geofizika pri razvedke rudnykh i ugol'nykh mestorozhdenij; Geofisica nuclear u prospeccion de yacimientos de carbon y otros minerales

    Energy Technology Data Exchange (ETDEWEB)

    Bulashevich, Yu P; Voskobojnikov, G M; Muzyukin, L V

    1962-01-15

    , intensivnost' kotoroj rezko oslablyaetsya s uvelicheniem srednego atomnogo nomera ehlementov sredy. EHtim metodom uspeshno vydelyayutsya rudnye zony s tyazhelymi ehlementami (svinets, vol'fram, rtut' i dr.). CHuvstvitel'nost' metoda poryadka 0,01 % SGGK uspeshno primenyaetsya na zhelezorudnykh (sideritovykh) mestorozhde- niyakh. Anomal'no bol'shoe sechenie zakhvata teplovykh nejtronov borom pozvolyaet vydelyat' v razreze skvazhin boronosnye zony metodami NGK i NNK. Meshayushchee vliyanie vody isklyuchaetsya inversionnymi zondami. EHti nejtronnye metody, a takzhe nejtronno-aktivatsionnyj karotazh nashli primenenie takzhe na mestorozhdeniyakh medi, margantsa, alyuminiya i nekotorykh drugikh. Nepreryvnyj aktivatsionnyj karotazh tselesoobrazen pri podkhodyashchem periode poluraspada voznikayushchego radioaktivnogo izotopa. Pri ehtom teoriya pozvolyaet ustanovit' optimal'nye usloviya karotazha (skorost', dlina zonda i t.d.). Registratsiya nejtronov pri foto-nejtronnom karotazhe pozvolyaet vydelyat' zony, obogashchennye berilliem, i otsenivat' soderzhaniya ehtogo ehlementa, nachinaya s 0,001%. Opyt podtverzhdaet ehffektivnost' i ehkonomicheskuyu tselesoobraznost' primeneniya metodov yadernoj geofiziki pri razvedke rudnykh i ugol'nykh mestorozhdenij. (author)

  12. Some factors influencing the absorption, retention and elimination of ruthenium; Facteurs agissant sur l'absorption, la retention et l'elimination du ruthenium; Nekotorye faktory, vliyakshchie na vsasyvanie, zaderzhku i vydelenie ruteniya; Factores que influyen sobre la absorcion, retencion y eliminacion de rutenio

    Energy Technology Data Exchange (ETDEWEB)

    Bruce, R. S. [Radiobiological Research Council, Medical Research Council, Harwell (United Kingdom)

    1963-02-15

    el suero inmediatamente despues de una inyeccion endovenosa o una administracion por via oral, pero desaparece con rapidez. Es probable que una vez que el rutenio sea absorbido en una forma que difunde libremente, parte del mismo reaccione con las proteinas del suero y que en un primer momento permanezca confinado en el espacio vascular; una parte es eliminada sin demora por los rinones y otra se difunde rapidamente en el espacio extravascular y en los tejidos. Esta ultima fraccion puede, bien reaccionar con el tejido y quedar retenida o difundirse de nuevo a la sangre, bien ser excretada. Despues de los primeros dias, la concentracion de rutenio en el suero disminuye a una velocidad que guarda una relacion estrecha con la velocidad de degradacion de las seroproteinas. Es posible que la retencion del rutenio en otros tejidos se rija tambien por su velocidad catabolica. (author) [Russian] Dva radioaktivnykh izotopa ruteniya, rutenij-103 (T1/2 = 40 dnej) i rutenij-106 (T1/2 = 1 god) obrazuyutsya v otnositel'no bol'shom kolichestve v rezul'tate rasshchepleniya urana-235. Pochti ket informatsii otnositel'no metabolizma ruteniya v organizme cheloveka, i privodimye soobrazheniya osnovyvayutsya ka issledovaniyakh krys i krolikov. KHarakter i razmer opasnosti, vyzyvaemoj radioruteniem, zavisit ne tol'ko ot uslovij zarazheniya, no i ot fizicheskogo i khimicheskogo sostoyaniya ruteniya. Rutenij-106, prinyatyj vnutr' v vide dvuokisi, vsasyvaetsya iz zheludochno-kishechnogo trakta v neznachitel'noj stepeni, kogda on prisutstvuet v forme chastits s nositelem, no pri vvedenii v vide kolloida bez nositelya pogloshchenie ego pochti takoe zhe, kak posle vvedeniya khlorida (3 - 5%). Nitratoproizvodnye nitroehila ruteniya mogut vsasyvat'sya eshche v bol'shej stepeni (u krolikov v srednem vsasyvaetsya okolo 13%). Vsasyvanie u negolodavshikh krys zakanchivaetsya v techenie odnogo chasa i ogranicheno vnutrizheludochnoJ dozoj. Ogranichennyj period vsasyvaniya mozhet ob'yasnyatsya skorost