Prognosis research strategy (PROGRESS) 4: Stratified medicine research

NARCIS (Netherlands)

A. Hingorani (Aroon); D.A.W.M. van der Windt (Daniëlle); R.D. Riley (Richard); D. Abrams; K.G.M. Moons (Karel); E.W. Steyerberg (Ewout); S. Schroter (Sara); W. Sauerbrei (Willi); D.G. Altman (Douglas); H. Hemingway; A. Briggs (Andrew); N. Brunner; P. Croft (Peter); J. Hayden (Jill); P.A. Kyzas (Panayiotis); N. Malats (Núria); G. Peat; P. Perel (Pablo); I. Roberts (Ian); A. Timmis (Adam)

2013-01-01

textabstractIn patients with a particular disease or health condition, stratified medicine seeks to identify thosewho will have the most clinical benefit or least harm from a specific treatment. In this article, thefourth in the PROGRESS series, the authors discuss why prognosis research should form

Progress Report Oct to Dec 1975(2)

International Nuclear Information System (INIS)

1976-01-01

Progress report NO. 2 of Tehran Nuclear Research Centre outlines a brief description of the progress made in each section of the centre. A complete list of dissertations for Master's degrees studied at the Nuclear Research Centre and a list of new technical employee are given at the beginning of the report. Research activities in the third section include, isotope separation, laser research, radiation chemistry, reactor management, environmental research, neutron physics, reactor engineering, and nuclear medicine. The fourth section deals with education and training; technical support and health physics are discussed in sections five and six respectively

Technical Progress of the New Worlds Observer Mission

Science.gov (United States)

Lo, Amy; Noecker, C.; Cash, W.; NWO Study Team

2009-01-01

We report on the technical progress of the New Worlds Observer (NWO) mission concept. NWO is a two spacecraft mission that is capable of detecting and characterizing extra-solar, terrestrial planets and planetary systems. NWO consists of an external starshade and an UV-optical space telescope, flying in tandem. The starshade is a petal-shaped, opaque screen that creates an extremely dark shadow large enough to shade the telescope aperture from the target star. The NWO team has been addressing the top technology challenges of the concept, and report here our progress. We will present the current mission configuration best suited to address Terrestrial Planet Finding requirements, and highlight the technological breakthroughs that we have achieved this year. In particular, we will report on progress made in precision deployables for the large starshade, and the trajectory & alignment control system for NWO. We will also briefly highlight advances in understanding the starshade optical performance.

Technical progress faced with the challenges of the energy sector in the future

International Nuclear Information System (INIS)

Maillard, D.

1999-01-01

The colloquium organised by the Association of Energy Economists dealing with the theme 'Technical progress faced with the challenges of the energy sector in the future' takes place against a backdrop of ever-increasing initiatives in this field, for example at the World Energy Council or the International Energy Agency Faith in technical progress is widespread but should be supported by studies without any preconceived ideas. Research and development efforts must be fully supported, and in a climate of opening markets and liberalization the public authorities have a major role to pay. Historically, the markets have always been able to meet new needs thanks to technology, but the ambitious targets that the international community has set itself regarding the emission of greenhouse gases imply technical improvements and major investments. (authors)

Treatment of progression of diffuse astrocytoma by herbal medicine ...

African Journals Online (AJOL)

It consisted of 4 types of herbal medicine which the subject was taking in form of tea once a day at regular intervals. The patient started phytotherapy along with temozolomide, which was the only oncological treatment she was under after the tumour had progressed. Following the finished chemotherapy, the patient ...

Evaporation by mechanical vapor recompression. Technical progress report, September 1-December 31, 1979

Energy Technology Data Exchange (ETDEWEB)

Iverson, C.H.; Coury, G.E.

1979-01-01

Progress to date in the development of a study of the application of the technologies of mechanical vapor recompression and falling film evaporators as applied to the beet sugar industry is reported. Progress is reported in the following areas: technical literature search and plant visitations of existing applications of VR/FFE.

Technical Developments and Clinical Use of Telemedicine in Sleep Medicine

Directory of Open Access Journals (Sweden)

Marie Bruyneel

2016-12-01

Full Text Available The use of assistive technology and telemedicine is likely to continue to shape our medical practice in the future, notably in the field of sleep medicine, especially within developed countries. Currently, the number of people suffering from obstructive sleep apnea syndrome (OSAS is increasing. Telemedicine (TM can be used in a variety of ways in sleep medicine: telediagnostics, teleconsultation, teletherapy and telemonitoring of patients being treated with positive pressure devices. In this review, we aim to summarize the recent scientific progresses of these techniques and their potential clinical applications and give consideration to the remaining problems related to TM application.

Experimental Facilities Division/User Program Division technical progress report 1999-2000

International Nuclear Information System (INIS)

2001-01-01

In October 1999, the two divisions of the Advanced Photon Source (APS), the Accelerator Systems Division (ASD) and the Experimental Facilities Division (XFD), were reorganized into four divisions (see high-level APS organizational chart, Fig. 1.1). In addition to ASD and XFD, two new divisions were created, the APS Operations Division (AOD), to oversee APS operations, and the User Program Division (UPD), to serve the APS user community by developing and maintaining the highest quality user technical and administration support. Previous XFD Progress Reports (ANL/APS/TB-30 and ANL/APS/TB-34) covered a much broader base, including APS user administrative support and what was previously XFD operations (front ends, interlocks, etc.) This Progress Report summarizes the main scientific and technical activities of XFD, and the technical support, research and development (R and D) activities of UPD from October 1998 through November 2000. The report is divided into four major sections, (1) Introduction, (2) SRI-CAT Beamlines, Technical Developments, and Scientific Applications, (3) User Technical Support, and (4) Major Plans for the Future. Sections 2 and 3 describe the technical activities and research accomplishments of the XFD and UPD personnel in supporting the synchrotron radiation instrumentation (SRI) collaborative access team (CAT) and the general APS user community. Also included in this report is a comprehensive list of publications (Appendix 1) and presentations (Appendix 2) by XFD and UPD staff during the time period covered by this report. The organization of section 2, SRI CAT Beamlines, Technical Developments, and Scientific Applications has been made along scientific techniques/disciplines and not ''geographical'' boundaries of the sectors in which the work was performed. Therefore items under the subsection X-ray Imaging and Microfocusing could have been (and were) performed on several different beamlines by staff in different divisions. The management of

Nuclear medicine and imaging research. Progress report, January 1, 1981-December 31, 1981

International Nuclear Information System (INIS)

Beck, R.N.; Cooper, M.C.

1981-09-01

The Progress Report for the period January 1, 1981-December 31, 1981 of the Franklin Memorial Research Institute discusses instrumentation and quantitative methods of evaluation in nuclear medicine and imaging research. Imaging systems and image evaluation are discussed in four projects: Radiation Detector Studies, Dual Purpose Scanner for Thyroid Imaging, Instrumentation for Image Processing and Enhancement, and Energy-Coded Processing in Nuclear Medicine

Sparking Thinking: Studying Modern Precision Medicine Will Accelerate the Progression of Traditional Chinese Medicine Patterns.

Science.gov (United States)

Liu, Bao-Cheng; Ji, Guang

2017-07-01

Incorporating "-omics" studies with environmental interactions could help elucidate the biological mechanisms responsible for Traditional Chinese Medicine (TCM) patterns. Based on the authors' own experiences, this review outlines a model of an ideal combination of "-omics" biomarkers, environmental factors, and TCM pattern classifications; provides a narrative review of the relevant genetic and TCM studies; and lists several successful integrative examples. Two integration tools are briefly introduced. The first is the integration of modern devices into objective diagnostic methods of TCM patterning, which would improve current clinical decision-making and practice. The second is the use of biobanks and data platforms, which could broadly support biological and medical research. Such efforts will transform current medical management and accelerate the progression of precision medicine.

Current situation of International Organization for Standardization/Technical Committee 249 international standards of traditional Chinese medicine.

Science.gov (United States)

Liu, Yu-Qi; Wang, Yue-Xi; Shi, Nan-Nan; Han, Xue-Jie; Lu, Ai-Ping

2017-05-01

To review the current situation and progress of traditional Chinese medicine (TCM) international standards, standard projects and proposals in International Organization for Standardization (ISO)/ technical committee (TC) 249. ISO/TC 249 standards and standard projects on the ISO website were searched and new standard proposals information were collected from ISO/TC 249 National Mirror Committee in China. Then all the available data were summarized in 5 closely related items, including proposed time, proposed country, assigned working group (WG), current stage and classifification. In ISO/TC 249, there were 2 international standards, 18 standard projects and 24 new standard proposals proposed in 2014. These 44 standard subjects increased year by year since 2011. Twenty-nine of them were proposed by China, 15 were assigned to WG 4, 36 were in preliminary and preparatory stage and 8 were categorized into 4 fifields, 7 groups and sub-groups based on International Classifification Standards. A rapid and steady development of international standardization in TCM can be observed in ISO/TC 249.

TREATMENT OF PROGRESSION OF DIFFUSE ASTROCYTOMA BY HERBAL MEDICINE: CASE REPORT.

Science.gov (United States)

Trogrlić, Ivo; Trogrlić, Dragan; Trogrlić, Zoran

2016-01-01

The paper presents the results of the use of phytotherapy in a 33-year-old woman who, after finishing the oncological treatment of diffuse astrocytoma, had tumour progression. Phytotherapy was introduced after the tumour had progressed. It consisted of 4 types of herbal medicine which the subject was taking in form of tea once a day at regular intervals. The patient started phytotherapy along with temozolomide, which was the only oncological treatment she was under after the tumour had progressed. Following the finished chemotherapy, the patient continued the treatment with herbal medicine only. She regularly took phytotherapy without interruption and to the fullest extent for 30 months, and the results of treatment were monitored by periodic scanning using nuclear magnetic resonance technique. The control scanning that was conducted after the end of combined treatment with temozolomide and phytotherapy showed tumour regression. The patient continued with phytotherapy after finishing chemotherapy and, during the following 24 months, it was the sole treatment option. In that period, the regression of the tumour continued, until a control examination 30 months after the introduction of phytotherapy showed no clinical and radiological signs of tumour. The results presented in this research paper clearly indicate the potential of phytotherapy in the treatment of some types of brain tumours. A complete regression of tumour following the treatment with nothing but herbal medicine offers support for such claim. Future research should demonstrate the effectiveness of phytotherapy, as a supplementary form of brain tumour treatment, and the results of this research should be compared with the existing information on the effectiveness of the protocols currently used in the treatment of these types of tumour.

Progressing a human embryonic stem-cell-based regenerative medicine therapy towards the clinic.

Science.gov (United States)

Whiting, Paul; Kerby, Julie; Coffey, Peter; da Cruz, Lyndon; McKernan, Ruth

2015-10-19

Since the first publication of the derivation of human embryonic stem cells in 1998, there has been hope and expectation that this technology will lead to a wave of regenerative medicine therapies with the potential to revolutionize our approach to managing certain diseases. Despite significant resources in this direction, the path to the clinic for an embryonic stem-cell-based regenerative medicine therapy has not proven straightforward, though in the past few years progress has been made. Here, with a focus upon retinal disease, we discuss the current status of the development of such therapies. We also highlight some of our own experiences of progressing a retinal pigment epithelium cell replacement therapy towards the clinic. © 2015 The Author(s).

The effects of environmental regulation and technical progress on CO2 Kuznets curve: An evidence from China

International Nuclear Information System (INIS)

Yin, Jianhua; Zheng, Mingzheng; Chen, Jian

2015-01-01

Based on environmental Kuznets curve theory, a panel data model which takes environmental regulation and technical progress as its moderating factors was developed to analyse the institutional and technical factors that affect the path of low-carbon economic development. The results indicated that there was a CO 2 emission Kuznets curve seen in China. Environmental regulation had a significant moderating effect on the curve, and the inflection of CO 2 emissions could come substantially earlier under stricter environmental regulation. Meanwhile, the impact of technical progress on the low-carbon economic development path had a longer hysteresis effect but restrained CO 2 emission during its increasing stage and accelerated its downward trend during the decreasing stage which was conducive to emission reduction. Strict environmental regulation could force the high-carbon emitting industries to transfer from the eastern regions to the central or the western regions of China, which would make the CO 2 Kuznets curve higher in its increasing stage and lower in its decreasing stage than that under looser regulation. Furthermore, energy efficiency, energy structure, and industrial structure exerted a significant direct impact on CO 2 emissions; we should consider the above factors as essential in the quest for low-carbon economic development. - Highlights: • Estimate moderating effect of environmental regulation and technical progress on EKC. • There was a CO 2 emission Kuznets curve in effect in China. • Environmental regulation presents significant moderating effect on EKC. • Technical progress moderates the relationship between income and CO 2 emissions

ERIP invention 637. Technical progress report 2nd quarter, April 1997--June 1997

Energy Technology Data Exchange (ETDEWEB)

Thacker, G.W.

1997-07-22

This technical report describes progress in the development of the Pegasus plow, a stalk and root embedding apparatus. Prototype testing is reported, and includes the addition of precision tillage. Disease data, organic matter, and nitrogen levels results are very briefly described. Progress in marketing is also reported. Current marketing issues include test use by cotton and wheat growers, establishment of dealer relationships, incorporation of design modifications, expansion of marketing activities, and expansion of loan and lease program.

Cassini RTG Program. Monthly technical progress report, 27 November--31 December 1995

International Nuclear Information System (INIS)

1996-01-01

This monthly technical progress report provided information on the following tasks: spacecraft integration and liaison; engineering support; safety analysis; qualified unicouple fabrication; ETG fabrication, assembly, and test; ground support equipment (GSE); RTG shipping and launch support; designs, reviews, and mission applications; project management, quality assurance, and reliability, and contractor acquired government owned (CAGO) property acquisition

Impact of Environmental Regulation and Technical Progress on Industrial Carbon Productivity: An Approach Based on Proxy Measure

Directory of Open Access Journals (Sweden)

Huan Zhang

2016-08-01

Full Text Available This research aims to study the main influencing factors of China’s industrial carbon productivity by incorporating environmental regulation and technical progress into an econometric model. The paper focuses on data from 35 of China’s industrial sectors and covers the period from 2006 to 2014, in order to examine the impact of environmental regulation and technical progress on carbon productivity. Methods applied include panel fixed effect model, panel random effect model and two stage least squares with instrumental variables (IV-2SLS. The effect of environmental regulation and technical progress has industrial heterogeneity. The paper subdivides industrial sectors into capital and technology intensive, resource intensive and labor intensive sectors according to factor intensiveness. The estimation results of the subgroups have uncovered that for capital and technology intensive and resource intensive sectors, environmental regulation has a more significant impact than technical progress; while for labor intensive sectors, innovation more significantly influences carbon productivity. In addition, foreign direct investment (FDI and industrialization level facilitate improving carbon productivity for the full sample. By contrast, industrial structure inhibits the overall industrial carbon productivity. The industry-specific results indicate that for capital and technology intensive sectors, optimizing of the industrial structure can improve carbon productivity; for resource intensive sectors, FDI and energy consumption structure should be emphasized more; for labor intensive sectors, industrialization levels help enhance carbon productivity. Finally the industrial sector-specific policy suggestions are proposed.

Recent progress in understanding activity cliffs and their utility in medicinal chemistry.

Science.gov (United States)

Stumpfe, Dagmar; Hu, Ye; Dimova, Dilyana; Bajorath, Jürgen

2014-01-09

The activity cliff concept is of high relevance for medicinal chemistry. Recent studies are discussed that have further refined our understanding of activity cliffs and suggested different ways of exploiting activity cliff information. These include alternative approaches to define and classify activity cliffs in two and three dimensions, data mining investigations to systematically detect all possible activity cliffs, the introduction of computational methods to predict activity cliffs, and studies designed to explore activity cliff progression in medicinal chemistry. The discussion of these studies is complemented with new findings revealing the frequency of activity cliff formation when different molecular representations are used and the distribution of activity cliffs across different targets. Taken together, the results have a number of implications for the practice of medicinal chemistry.

Technical efficiency of Shiraz school of medicine in research and education domains: a data envelopment analysis.

Science.gov (United States)

Delavari, Somayeh; Rezaee, Rita; Hatam, Nahid; Delavari, Sajad

2016-01-01

Efficiency evaluation of universities and faculties is one of the tools that help managers to identify the departments' strengths and weakness. The main objective of the present research was to measure and compare the technical efficiency of Shiraz school of medicine departments using Data Envelopment Analysis (DEA) technique. This cross-sectional and retrospective study was performed on clinical and non-clinical departments in research and education domains over the period of 2006 to 2011. Different inputs and outputs were considered for research and educational domain separately. Efficiency was measured based on the observed optimal performance. Findings showed that pathology and anatomy departments achieved the score of 100 in technical efficiency in education during 2006 to 2011. During this period, parasitology, psychiatric and pediatrics department's achieved the score of 100 for technical efficiency in research domain. The lowest mean of relative educational efficiency belonged to orthopedic department; as to relative research efficiency, the lowest mean was shown in orthopedics and genetics departments. The mean technical efficiency of non-medical departments in education and research domain was 91.93 and 76.08, respectively, while the mean technical efficiency of the clinical department in educational and research fields was 91.02 and 82.23, respectively. Using multiple input and output in DEA technique provided a comprehensive evaluation of efficiency in Shiraz school of medicine departments. The DEA could successfully estimate the technical efficiency of the departments in research and educational fields. Moreover, the deficiency in each department was found; this could help them to plan for improvement.

Technical protocol for laboratory tests of transformation of veterinary medicinal products and biocides in liquid manures. Version 1.0

Energy Technology Data Exchange (ETDEWEB)

Kreuzig, Robert [Technische Univ. Braunschweig (Germany). Inst. fuer Oekologische Chemie und Abfallanalytik

2010-07-15

The technical protocol under consideration describes a laboratory test method to evaluate the transformation of chemicals in liquid bovine and pig manures under anaerobic conditions and primarily is designed for veterinary medicinal products and biocides. The environmentally relevant entry routes into liquid manures occur via urine and feces of cattle and pigs in stable housings after excretion of veterinary medicinal products as parent compounds or metabolites and after the application of biocides in animal housings. Further entry routes such as solid dung application and direct dung pat deposition by production animals on pasture are not considered by this technical protocol. Thus, this technical protocol focused on the sampling of excrements from cattles and pigs kept in stables and fed under standard nutrition conditions. This approach additionally ensures that excrement samples are operationally free of any contamination by veterinary medicinal products and biocides. After the matrix characterization, reference-manure samples are prepared from the excrement samples by adding tap water to adjust defined dry substance contents typical for bovine or pig manures. This technical protocol comprehends a tiered experimental design in two parts: (a) Sampling of excrements and preparation of reference bovine and pig manures; (b) Testing of anaerobic transformation of chemicals in reference manures.

Research Progress in the Application of Chinese Herbal Medicines in Aquaculture: A Review

Directory of Open Access Journals (Sweden)

Hongyu Pu

2017-10-01

Full Text Available Due to increasing safety concerns regarding human consumption of fish products, an increasing number of medicinal chemicals are prohibited from use in aquaculture. As a result, Chinese herbal medicines are being increasingly used, coining the use of the term “green medicine.” Research shows that Chinese herbal medicines have many beneficial effects on fish, including growth promotion, enhancement of disease resistance, and improvement in meat quality. Many effective ingredients have been discovered in Chinese herbal medicines, which function to promote feed intake, improve meat flavor, and increase digestive enzyme activity. They also regulate and participate in processes that improve the specific and non-specific immunity of fish; however, the composition of Chinese herbal medicines is very complex and it is often difficult to identify the effective ingredients. This article reviews the latest research and application progress in Chinese herbal medicines regarding growth and feed utilization, immunity and disease resistance, and the meat quality of cultured fish. It also discusses research on the chemical constituents of classical Chinese medicinal herbs and problems with the application of Chinese herbal medicines in fish culture. This article concludes by proposing that future studies on Chinese herbal medicines should focus on how to cheaply refine and extract the effective ingredients in classical Chinese medicinal herbs, as well as how to use them efficiently in aquaculture.

Platelet-rich plasma regenerative medicine sports medicine, orthopedic, and recovery of musculoskeletal injuries

CERN Document Server

Santana, Maria; Belangero, William; Luzo, Angela

2014-01-01

Platelet-Rich Plasma (PRP) has gained tremendous popularity in recent years as a treatment option for specialties including Orthopedics, Dentistry, Sports Medicine, Otorhinolaryngology, Neurosurgery, Ophthalmology, Urology, Vascular, Cardiothoracic and Maxillofacial Surgery, and Veterinarian Medicine. Nowadays, PRP and Stem Cell Science have added an exciting dimension to tissue repair. This book begins by giving the reader a broad overview of current progress as well as a discussion of the technical aspects of preparation and therapeutic use of autologous PRP. It is followed by a review of platelet structure, function and major growth factors in PRP (PDGF and TGFβ).The third chapter outlines the basic principles of biochemical cellular metabolism that increases the efficacy of PRP. Analogous to the preparation of soil for a garden, restoring cellular health should be the first consideration in Regenerative Medicine. Standardization of PRP preparation to clinical use still remains a challenging prospect. In ...

Monitoring the Durability Performance of Concrete in Nuclear Waste Containment. Technical Progress Report No. 3

International Nuclear Information System (INIS)

Ulm, Franz-Josef

2000-01-01

OAK-B135 Monitoring the Durability Performance of Concrete in Nuclear Waste Containment. Technical Progress Report No. 3(NOTE: Part II A item 1 indicates ''PAPER'', but a report is attached electronically)

Total Factor Productivity Growth, Technical Progress & Efficiency Change in Vietnam Coal Industry - Nonparametric Approach

Science.gov (United States)

Phuong, Vu Hung

2018-03-01

This research applies Data Envelopment Analysis (DEA) approach to analyze Total Factor Productivity (TFP) and efficiency changes in Vietnam coal mining industry from 2007 to 2013. The TFP of Vietnam coal mining companies decreased due to slow technological progress and unimproved efficiency. The decadence of technical efficiency in many enterprises proved that the coal mining industry has a large potential to increase productivity through technical efficiency improvement. Enhancing human resource training, technology and research & development investment could help the industry to improve efficiency and productivity in Vietnam coal mining industry.

Sludge Treatment Evaluation: 1992 Technical progress

International Nuclear Information System (INIS)

Silva, L.J.; Felmy, A.R.; Ding, E.R.

1993-01-01

This report documents Fiscal Year 1992 technical progress on the Sludge Treatment Evaluation Task, which is being conducted by Pacific Northwest Laboratory. The objective of this task is to develop a capability to predict the performance of pretreatment processes for mixed radioactive and hazardous waste stored at Hanford and other US Department of Energy (DOE) sites. Significant cost savings can be achieved if radionuclides and other undesirable constituents can be effectively separated from the bulk waste prior to final treatment and disposal. This work is initially focused on chemical equilibrium prediction of water washing and acid or base dissolution of Hanford single-shell tank (SST) sludges, but may also be applied to other steps in pretreatment processes or to other wastes. Although SST wastes contain many chemical species, there are relatively few constituents -- Na, Al, NO 3 , NO 2 , PO 4 , SO 4 , and F -- contained in the majority of the waste. These constituents comprise 86% and 74% of samples from B-110 and U-110 SSTS, respectively. The major radionuclides of interest (Cs, Sr, Tc, U) are present in the sludge in small molal quantities. For these constituents, and other important components that are present in small molal quantities, the specific ion-interaction terms used in the Pitzer or NRTL equations may be assumed to be zero for a first approximation. Model development can also be accelerated by considering only the acid or base conditions that apply for the key pretreatment steps. This significantly reduces the number of chemical species and chemical reactions that need to be considered. Therefore, significant progress can be made by developing all the specific ion interactions for a base model and an acid dissolution model

Sludge Treatment Evaluation: 1992 Technical progress

Energy Technology Data Exchange (ETDEWEB)

Silva, L J; Felmy, A R; Ding, E R

1993-01-01

This report documents Fiscal Year 1992 technical progress on the Sludge Treatment Evaluation Task, which is being conducted by Pacific Northwest Laboratory. The objective of this task is to develop a capability to predict the performance of pretreatment processes for mixed radioactive and hazardous waste stored at Hanford and other US Department of Energy (DOE) sites. Significant cost savings can be achieved if radionuclides and other undesirable constituents can be effectively separated from the bulk waste prior to final treatment and disposal. This work is initially focused on chemical equilibrium prediction of water washing and acid or base dissolution of Hanford single-shell tank (SST) sludges, but may also be applied to other steps in pretreatment processes or to other wastes. Although SST wastes contain many chemical species, there are relatively few constituents -- Na, Al, NO[sub 3], NO[sub 2], PO[sub 4], SO[sub 4], and F -- contained in the majority of the waste. These constituents comprise 86% and 74% of samples from B-110 and U-110 SSTS, respectively. The major radionuclides of interest (Cs, Sr, Tc, U) are present in the sludge in small molal quantities. For these constituents, and other important components that are present in small molal quantities, the specific ion-interaction terms used in the Pitzer or NRTL equations may be assumed to be zero for a first approximation. Model development can also be accelerated by considering only the acid or base conditions that apply for the key pretreatment steps. This significantly reduces the number of chemical species and chemical reactions that need to be considered. Therefore, significant progress can be made by developing all the specific ion interactions for a base model and an acid dissolution model.

The history of aesthetic medicine and surgery.

Science.gov (United States)

Krueger, Nils; Luebberding, Stefanie; Sattler, Gerhard; Hanke, C William; Alexiades-Armenakas, Macrene; Sadick, Neil

2013-07-01

The history of beauty is as old as mankind itself--throughout history people have tried to improve their attractiveness and to enhance their beauty. The technical basis for many of nowadays procedures like lipoplasty, breast augmentation or rhinoplasty was thereby initiated more than a hundred years ago and evolved to the modern standards of today. The aim of this article is to recall the early days of aesthetic medicine and show the swift progress up to the highly specialized medical discipline of our modern time. Combining the past, present and future of aesthetic medicine, allows to incorporate this perspective and ultimately to delivery better patient care.

Decontamination Systems Information and Research Program. Quarterly technical progress report, January 1--March 31, 1994

Energy Technology Data Exchange (ETDEWEB)

1994-05-01

West Virginia University (WVU) and the US DOE Morgantown Energy Technology Center (METC) entered into a Cooperative Agreement on August 29, 1992 entitled ``Decontamination Systems Information and Research Programs.`` Stipulated within the Agreement is the requirement that WVU submit to METC a series of Technical Progress Reports on a quarterly basis. This report comprises the first Quarterly Technical Progress Report for Year 2 of the Agreement. This report reflects the progress and/or efforts performed on the sixteen (16) technical projects encompassed by the Year 2 Agreement for the period of January 1 through March 31, 1994. In situ bioremediation of chlorinated organic solvents; Microbial enrichment for enhancing in-situ biodegradation of hazardous organic wastes; Treatment of volatile organic compounds (VOCs) using biofilters; Drain-enhanced soil flushing (DESF) for organic contaminants removal; Chemical destruction of chlorinated organic compounds; Remediation of hazardous sites with steam reforming; Soil decontamination with a packed flotation column; Use of granular activated carbon columns for the simultaneous removal of organics, heavy metals, and radionuclides; Monolayer and multilayer self-assembled polyion films for gas-phase chemical sensors; Compact mercuric iodide detector technology development; Evaluation of IR and mass spectrometric techniques for on-site monitoring of volatile organic compounds; A systematic database of the state of hazardous waste clean-up technologies; Dust control methods for insitu nuclear and hazardous waste handling; Winfield Lock and Dam remediation; and Socio-economic assessment of alternative environmental restoration technologies.

Environmental Research Division technical progress report, January 1984-December 1985

International Nuclear Information System (INIS)

1986-05-01

Technical progress in the various research and assessment activities of Argonne National Laboratory's Environmental Research Division is reported for the period 1984 to 1985. Textual, graphic, and tabular information is used to briefly summarize (in separate chapters) the work of the Division's Atmospheric Physics, Environmental Effects Research, Environmental Impacts, Fundamental Molecular Physics and Chemistry, and Waste Management Programs. Information on professional qualifications, awards, and outstanding professional activities of staff members, as well as lists of publications, oral presentations, special events organized, and participants in educational programs, are provided in appendices at the end of each chapter

Environmental Research Division technical progress report, January 1984-December 1985

Energy Technology Data Exchange (ETDEWEB)

1986-05-01

Technical progress in the various research and assessment activities of Argonne National Laboratory's Environmental Research Division is reported for the period 1984 to 1985. Textual, graphic, and tabular information is used to briefly summarize (in separate chapters) the work of the Division's Atmospheric Physics, Environmental Effects Research, Environmental Impacts, Fundamental Molecular Physics and Chemistry, and Waste Management Programs. Information on professional qualifications, awards, and outstanding professional activities of staff members, as well as lists of publications, oral presentations, special events organized, and participants in educational programs, are provided in appendices at the end of each chapter.

Institutional effectiveness of REDD+ MRV: Countries progress in implementing technical guidelines and good governance requirements

NARCIS (Netherlands)

Ochieng, R.M.; Visseren-Hamakers, Ingrid; Arts, B.; Brockhaus, M.; Herold, M.

2016-01-01

The UNFCCC requires REDD+ countries wishing to receive results-based payments to measure, report and verify (MRV) REDD+ impacts; and outlines technical guidelines and good governance requirements for MRV. This article examines institutional effectiveness of REDD+ MRV by assessing countries’ progress

Index to Nuclear Safety: a technical progress review by chrology, permuted title, and author, Volume 11(1) through Volume 20(6)

Energy Technology Data Exchange (ETDEWEB)

Cottrell, W B; Passiakos, M

1980-06-01

This index to Nuclear Safety, a bimonthly technical progress review, covers articles published in Nuclear Safety, Volume II, No. 1 (January-February 1970), through Volume 20, No. 6 (November-December 1979). It is divided into three sections: a chronological list of articles (including abstracts) followed by a permuted-title (KWIC) index and an author index. Nuclear Safety, a bimonthly technical progress review prepared by the Nuclear Safety Information Center (NSIC), covers all safety aspects of nuclear power reactors and associated facilities. Over 600 technical articles published in Nuclear Safety in the last ten years are listed in this index.

Integrative Medicine in Preventive Medicine Education

OpenAIRE

Jani, Asim A.; Trask, Jennifer; Ali, Ather

2015-01-01

During 2012, the USDHHS?s Health Resources and Services Administration funded 12 accredited preventive medicine residencies to incorporate an evidence-based integrative medicine curriculum into their training programs. It also funded a national coordinating center at the American College of Preventive Medicine, known as the Integrative Medicine in Preventive Medicine Education (IMPriME) Center, to provide technical assistance to the 12 grantees. To help with this task, the IMPriME Center esta...

Nonequilibrium photochemical reactions induced by lasers. Technical progress report

International Nuclear Information System (INIS)

Steinfeld, J.I.

1978-04-01

Research has progressed in six principal subject areas of interest to DOE advanced (laser) isotope separation efforts. These are (1) Infrared double resonance spectroscopy of molecules excited by multiple infrared photon absorption, particularly SF 6 and vinyl chloride. (2) Infrared multiphoton excitation of metastable triplet-state molecules, e.g., biacetyl. (3) An Information Theory analysis of multiphoton excitation and collisional deactivation has been carried out. (4) The mechanism of infrared energy deposition and multiphoton-induced reactions in chlorinated ethylene derivatives; and RRKM (statistical) model accounts for all observed behavior of the system, and a deuterium-specific reaction pathway has been identified. (5) Diffusion-enhanced laser isotope separation in N 16 O/N 18 O. (6) A technical evaluation of laser-induced chemistry and isotope separation

Projects at the component development and integration facility. Quarterly technical progress report, April 1, 1994--June 30, 1994

International Nuclear Information System (INIS)

1994-01-01

This quarterly technical progress report presents progress on the projects at the Component Development and Integration Facility (CDIF) during the third quarter of FY94. The CDIF is a major Department of Energy test facility in Butte, Montana, operated by MSE, Inc. Projects in progress include: Biomass Remediation Project; Heavy Metal-Contaminated Soil Project; MHD Shutdown; Mine Waste Technology Pilot Program; Plasma Projects; Resource Recovery Project; and Spray Casting Project

[Research Progress of Carrion-breeding Phorid Flies for Post-mortem Interval Estimation in Forensic Medicine].

Science.gov (United States)

Li, L; Feng, D X; Wu, J

2016-10-01

It is a difficult problem of forensic medicine to accurately estimate the post-mortem interval. Entomological approach has been regarded as an effective way to estimate the post-mortem interval. The developmental biology of carrion-breeding flies has an important position at the post-mortem interval estimation. Phorid flies are tiny and occur as the main or even the only insect evidence in relatively enclosed environments. This paper reviews the research progress of carrion-breeding phorid flies for estimating post-mortem interval in forensic medicine which includes their roles, species identification and age determination of immatures. Copyright© by the Editorial Department of Journal of Forensic Medicine.

Modeling the impacts of climate change and technical progress on the wheat yield in inland China: An autoregressive distributed lag approach.

Science.gov (United States)

Zhai, Shiyan; Song, Genxin; Qin, Yaochen; Ye, Xinyue; Lee, Jay

2017-01-01

This study aims to evaluate the impacts of climate change and technical progress on the wheat yield per unit area from 1970 to 2014 in Henan, the largest agricultural province in China, using an autoregressive distributed lag approach. The bounded F-test for cointegration among the model variables yielded evidence of a long-run relationship among climate change, technical progress, and the wheat yield per unit area. In the long run, agricultural machinery and fertilizer use both had significantly positive impacts on the per unit area wheat yield. A 1% increase in the aggregate quantity of fertilizer use increased the wheat yield by 0.19%. Additionally, a 1% increase in machine use increased the wheat yield by 0.21%. In contrast, precipitation during the wheat growth period (from emergence to maturity, consisting of the period from last October to June) led to a decrease in the wheat yield per unit area. In the short run, the coefficient of the aggregate quantity of fertilizer used was negative. Land size had a significantly positive impact on the per unit area wheat yield in the short run. There was no significant short-run or long-run impact of temperature on the wheat yield per unit area in Henan Province. The results of our analysis suggest that climate change had a weak impact on the wheat yield, while technical progress played an important role in increasing the wheat yield per unit area. The results of this study have implications for national and local agriculture policies under climate change. To design well-targeted agriculture adaptation policies for the future and to reduce the adverse effects of climate change on the wheat yield, climate change and technical progress factors should be considered simultaneously. In addition, adaptive measures associated with technical progress should be given more attention.

Modeling the impacts of climate change and technical progress on the wheat yield in inland China: An autoregressive distributed lag approach.

Directory of Open Access Journals (Sweden)

Shiyan Zhai

Full Text Available This study aims to evaluate the impacts of climate change and technical progress on the wheat yield per unit area from 1970 to 2014 in Henan, the largest agricultural province in China, using an autoregressive distributed lag approach. The bounded F-test for cointegration among the model variables yielded evidence of a long-run relationship among climate change, technical progress, and the wheat yield per unit area. In the long run, agricultural machinery and fertilizer use both had significantly positive impacts on the per unit area wheat yield. A 1% increase in the aggregate quantity of fertilizer use increased the wheat yield by 0.19%. Additionally, a 1% increase in machine use increased the wheat yield by 0.21%. In contrast, precipitation during the wheat growth period (from emergence to maturity, consisting of the period from last October to June led to a decrease in the wheat yield per unit area. In the short run, the coefficient of the aggregate quantity of fertilizer used was negative. Land size had a significantly positive impact on the per unit area wheat yield in the short run. There was no significant short-run or long-run impact of temperature on the wheat yield per unit area in Henan Province. The results of our analysis suggest that climate change had a weak impact on the wheat yield, while technical progress played an important role in increasing the wheat yield per unit area. The results of this study have implications for national and local agriculture policies under climate change. To design well-targeted agriculture adaptation policies for the future and to reduce the adverse effects of climate change on the wheat yield, climate change and technical progress factors should be considered simultaneously. In addition, adaptive measures associated with technical progress should be given more attention.

The Impacts of Technical Progress on Sulfur Dioxide Kuznets Curve in China: A Spatial Panel Data Approach

Directory of Open Access Journals (Sweden)

Zhimin Zhou

2017-04-01

Full Text Available This paper aims to reveal the nexus for sulfur dioxide (SO2 emission and income, as well as the effects of technical progress on SO2 emission in China based on environment Kuznets curve (EKC hypothesis. The spatial panel technique is used in case the coefficient estimates are biased due to the negligence of spatial dependence. With the provincial panel data of China from 2004 to 2014, this is the first research that finds an inverse N-trajectory of the relationship between SO2 emission and economic growth and confirms the beneficial impacts of technical advancement on SO2 emission abatement. The empirical results also suggest that the industrial structure change is an important driving force of the SO2 EKC. In addition, the direct and spillover effects of determinants on sulfur emission are clarified and estimated by a correct approach. Finally, we check the stability of our conclusions on the EKC shape for SO2 and technical progress effects when controlling for different variables and specifications, through which we find the turning points are sensitive to variables selections.

Technical progress and climatic change

International Nuclear Information System (INIS)

Ausubel, J.H.

1995-01-01

The global warming debate has neglected and thus underestimated the importance of technical change in considering reduction in greenhouse gases and adaptation to climate change. Relevant quantitative cases of long-run technical change during the past 100 years are presented in computing, communications, transport, energy, and agriculture. A noteworthy technological trajectory is that of decarbonization, or decreasing carbon intensity of primary energy. If human societies have not yet reached the end of the history of technology, the cost structure for mitigation and adaptation changes could be cheap. (Author)

Western Research Institute: Annual technical progress report, October 1987--September 1988

Energy Technology Data Exchange (ETDEWEB)

1988-12-01

This report describes the technical progress made by the Western Research Institute of the University of Wyoming Research Institute of the University of Wyoming Research Corporation on work performed for the period October 1, 1987 through September 30, 1988. This research involves five resource areas: oil shale, tar sand, underground coal gasification, advanced process technology, and advanced fuels research. Under the terms of the cooperative agreement, an annual project plan has been approved by DOE. The work reported herein reflects the implementation of the research in the plan and follows the structure used therein. 49 refs., 32 figs., 87 tabs.

Technical meeting on progress in managing, and limiting the consequences of events exceeding the design basis

International Nuclear Information System (INIS)

Fabian, H.

2004-01-01

The Technical Groups on 'Reactor Safety' and 'Thermodynamics and Fluid Dynamics' of the Kerntechnische Gesellschaft e.V. organized a joint technical meeting on 'Progress in Managing, and Limiting the Consequences of, Events Exceeding the Design Basis' at the FTU Training Center of the Karlsruhe Research Center. The topic chosen, the papers presented, the presenters, and the non-technical part of the program met with lively interest on the part of institutions in the nuclear field. These were the objectives of the technical meeting: - Establishing a forum for communicating relevant topics. - In-depth discussion of the main topic, i.e. the advanced development of reactor safety, research in the field, and its application, in twenty selected papers presented by speakers from different institutions. - Presentation of topical work in a nuclear technology institution, the Karlsruhe Research Center. (orig.) [de

Studies in theoretical high energy particle physics: Technical progress report [February 1987-February 1988

International Nuclear Information System (INIS)

Sukhatme, U.P.; Keung, Wai-Yee; Kovacs, E.

1988-02-01

This is a technical progress report for grant No. FG02-84ER40173 for the period February 1987 to February 1988. Our research on supersymmetric quantum mechanics has yielded many interesting results. In particular, a systematic approach to the tunneling problem in double well potentials has been developed. Higgs boson related physics at the high energy hadron colliders has been extensively studied

[What is beauty? : Manifest for an aesthetic character medicine].

Science.gov (United States)

Harth, W

2017-12-01

Aesthetic medicine has in recent decades attained a growing social significance and firm place in the medical profession image. In a short time, a variety of technical procedures and processes have been developed and applied by specialized physicians. A further leading medical discussion regarding the central question "What is beauty" is missing compared with the technologically innovative progress. Beauty is characterized by an individual and subjective pleasure. Social media and fashion trends exert a central influence on common beauty ideals and aesthetic medicine. In practice, the artificial intervention must accord to the individual personality. Therefore, the professional term Aesthetic Medicine is insufficient and should be replaced by "Aesthetic Character Medicine". The particular purpose is the aim of graceful aging and a sustained adequate result which outlasts the zeitgeist. This requires medical know how and clear aesthetic self-conception of the physician. "Aesthetic Character Medicine" can be realized in a discourse, with the 10-step plan presented in this article.

The role of technical progress in the process of recalculating oil reserves; Le role du progres technique dans le processus de renouvellement des reserves petrolieres

Energy Technology Data Exchange (ETDEWEB)

Boulard, J.N. [Total/Fina/Institut Francais du Petrole (IFP), 92 - Rueil-Malmaison (France)

1999-08-01

Contrary to the concept of resources (which is essentially a geological one), the notion of reserves designates the quantities that are technically and economically recoverable. Beyond the production-related effect, the reserves therefore evolve over time in accordance with numerous technical and economic parameters. Among these parameters, it can be seen that technical progress plays a considerable role throughout the process of converting resources into reserves, including progress in the identification, accessibility and processing of the resources, and improvements in economic viability. After having tackled the problem of measuring the 'technical progress effects' and citing examples, we demonstrate that the evolution in oil reserves is subject to three types of impact. These are a quantitative impact by significantly improving the recovery rates or making it possible to identify hitherto undetectable oil fields, a qualitative impact by widening the resource base thanks to the adoption of new categories of oil (in particular the so-called 'unconventional' oils) and by carrying out the gradual substitution between these resources of differing qualities. There is also a dynamic impact, through the acceleration of resource availability. Through these three approaches, technical progress makes makes it possible to ensure continuity in oil supply and contributes significantly to the recalculation of reserves. It therefore acts as a compensating factor, counterbalancing the progressive depletion of resources. (author)

Renal diagnostic nuclear medicine procedures in progressive systemic scleroderma (PSS)

Energy Technology Data Exchange (ETDEWEB)

Ammari, B.; Hotze, A.; Gruenwald, F.; Biersack, H.J.; Blitz, H.; Kuester, W.; Kreysel, H.W.

1989-02-01

The involvement of kidneys in progressive systemic scleroderma (PSS) is one of the most frequent causes of death in this disease. Using clinical criteria and laboratory tests only the frequency of kidney involvement would be clearly underestimated. Invasive diagnostic procedures such as biopsy and angiography can not be applied in those patients. Nuclear medicine techniques (hippurate clearance, DMSA-scan), however, offer non invasive and sensitive methods in the diagnosis of renal involvement in PSS patients. In our study 46 of 76 patients (60%) revealed pathologic findings. The mentioned diagnostic techniques show a high sensitivity and are in agreement with pathological findings described in PSS.

Renal diagnostic nuclear medicine procedures in progressive systemic scleroderma (PSS)

International Nuclear Information System (INIS)

Ammari, B.; Hotze, A.; Gruenwald, F.; Biersack, H.J.; Blitz, H.; Kuester, W.; Kreysel, H.W.

1989-01-01

The involvement of kidneys in progressive systemic scleroderma (PSS) is one of the most frequent causes of death in this disease. Using clinical criteria and laboratory tests only the frequency of kidney involvement would be clearly underestimated. Invasive diagnostic procedures such as biopsy and angiography can not be applied in those patients. Nuclear medicine techniques (hippurate clearance, DMSA-scan), however, offer non invasive and sensitive methods in the diagnosis of renal involvement in PSS patients. In our study 46 of 76 patients (60%) revealed pathologic findings. The mentioned diagnostic techniques show a high sensitivity and are in agreement with pathological findings described in PSS. (orig.) [de

Amarillo National Resource Center for Plutonium. Quarterly technical progress report, May 1--July 31, 1998

Energy Technology Data Exchange (ETDEWEB)

NONE

1998-09-01

Progress is reported on research projects related to the following: Electronic resource library; Environment, safety, and health; Communication, education, training, and community involvement; Nuclear and other materials; and Reporting, evaluation, monitoring, and administration. Technical studies investigate remedial action of high explosives-contaminated lands, radioactive waste management, nondestructive assay methods, and plutonium processing, handling, and storage.

Organisation of nuclear medicine services. Health physics. Technical and administrative arrangement

International Nuclear Information System (INIS)

Chanteur, J.; Pellerin, P.

1975-01-01

Apart from safety and quality requirements the organisation of nuclear medicine services, or more generally of installations where non-sealed radioactive sources are used, is governed by profitability and efficiency criteria. In view of the high price of products and apparatus the equipment must be based on a rationalisation of options guiding the organisation arrangements as a whole. The following items are dealt with in succession: various categories of installations; general planning of equipment; equipment regulations based on a major requirement, the confinement of contamination sources; working rules examined with respect to the systematics adopted by the International Health Physics Commission and referred in turn to the protection of the patient and that of the surroundings practical observations concerning administrative and technical questions [fr

Surgical resident technical skill self-evaluation: increased precision with training progression.

Science.gov (United States)

Quick, Jacob A; Kudav, Vishal; Doty, Jennifer; Crane, Megan; Bukoski, Alex D; Bennett, Bethany J; Barnes, Stephen L

2017-10-01

Surgical resident ability to accurately evaluate one's own skill level is an important part of educational growth. We aimed to determine if differences exist between self and observer technical skill evaluation of surgical residents performing a single procedure. We prospectively enrolled 14 categorical general surgery residents (six post-graduate year [PGY] 1-2, three PGY 3, and five PGY 4-5). Over a 6-month period, following each laparoscopic cholecystectomy, residents and seven faculty each completed the Objective Structured Assessment of Technical Skills (OSATS). Spearman's coefficient was calculated for three groups: senior (PGY 4-5), PGY3, and junior (PGY 1-2). Rho (ρ) values greater than 0.8 were considered well correlated. Of the 125 paired assessments (resident-faculty each evaluating the same case), 58 were completed for senior residents, 54 for PGY3 residents, and 13 for junior residents. Using the mean from all OSATS categories, trainee self-evaluations correlated well to faculty (senior ρ 0.97, PGY3 ρ 0.9, junior ρ 0.9). When specific OSATS categories were analyzed, junior residents exhibited poor correlation in categories of respect for tissue (ρ -0.5), instrument handling (ρ 0.71), operative flow (ρ 0.41), use of assistants (ρ 0.05), procedural knowledge (ρ 0.32), and overall comfort with the procedure (ρ 0.73). PGY3 residents lacked correlation in two OSATS categories, operative flow (ρ 0.7) and procedural knowledge (ρ 0.2). Senior resident self-evaluations exhibited strong correlations to observers in all areas. Surgical residents improve technical skill self-awareness with progressive training. Less-experienced trainees have a tendency to over-or-underestimate technical skill. Copyright © 2017 Elsevier Inc. All rights reserved.

Radiology and the internet, basic principles and technical requirements

International Nuclear Information System (INIS)

Boegl, K.

2000-01-01

As a new communication media the Internet has revolutionized the global exchange of information which is one of the major sources of progress in medicine. This article reviews the history of the Internet's evolution and describes some fundamental technical concepts. The importance of Internet services for everyday professional work is examined with special consideration of radiology. Special emphasis is laid on the current technical limitations that have delayed a broad practical implementation of tele-medical applications. As a highly innovative medical speciality, radiology has always been at the forefront of research and development in the field of clinical Internet applications. By taking a look at recent innovations, the impact of the Internet on the radiologist's working environment of the future is highlighted. (orig.) [de

Productivity Change, Technical Progress, and Relative Efficiency Change in the Public Accounting Industry

OpenAIRE

Rajiv D. Banker; Hsihui Chang; Ram Natarajan

2005-01-01

We present evidence on components of productivity change in the public accounting industry toward the end of the 20th century. Using revenue and human resource data from 64 of the 100 largest public accounting firms in the United States for the 1995--1999 period, we analyze productivity change, technical progress, and relative efficiency change over time. The average public accounting firm experienced a productivity growth of 9.5% between 1995 and 1999. We find support for the hypothesis that...

GPHS-RTGs in support of the Cassini RTG Program. Semi annual technical progress report, September 26, 1994--April 2, 1995

International Nuclear Information System (INIS)

1995-01-01

The technical progress achieved during the period 26 September 1994 through 2 April 1995 on Contract DE-AC03-91SF18852 Radioisotope Thermoelectric Generators and Ancillary Activities is described herein. Monthly technical activity for the period 27 February 1995 through 2 April 1995 is included in this progress report. The report addresses tasks, including: spacecraft integration and liaison; engineering support; safety; qualified unicouple production; ETG Fabrication, assembly, and test; ground support equipment; RTG shipping and launch support; designs, reviews, and mission applications; project management, quality assurance, reliability, contract changes, CAGO acquisition (operating funds), and CAGO maintenance and repair; and CAGO acquisition (capital funds)

Nuclear medicine and imaging research (quantitative studies in radiopharmaceutical science). Progress report, January 1, 1984-December 31, 1984

International Nuclear Information System (INIS)

Beck, R.N.; Cooper, M.D.

1984-09-01

This report presents progress in the areas of cardiac nuclear medicine, other imaging studies, investigations with biomolecules, and assessment of risks associated with the clinical use of radiopharmaceuticals

Inadequate progress for women in academic medicine: findings from the National Faculty Study.

Science.gov (United States)

Carr, Phyllis L; Gunn, Christine M; Kaplan, Samantha A; Raj, Anita; Freund, Karen M

2015-03-01

Women have entered academic medicine in significant numbers for 4 decades and now comprise 20% of full-time faculty. Despite this, women have not reached senior positions in parity with men. We sought to explore the gender climate in academic medicine as perceived by representatives to the Association of American Medical Colleges (AAMC) Group on Women in Medicine and Science (GWIMS) and Group on Diversity and Inclusion (GDI). We conducted a qualitative analysis of semistructured telephone interviews with GWIMS and GDI representatives and other senior leaders at 24 randomly selected medical schools of the 1995 National Faculty Study. All were in the continental United States, balanced for public/private status and AAMC geographic region. Interviews were audiotaped, transcribed, and organized into content areas before an inductive thematic analysis was conducted. Themes that were expressed by multiple informants were studied for patterns of association. Five themes were identified: (1) a perceived wide spectrum in gender climate; (2) lack of parity in rank and leadership by gender; (3) lack of retention of women in academic medicine (the "leaky pipeline"); (4) lack of gender equity in compensation; and (5) a disproportionate burden of family responsibilities and work-life balance on women's career progression. Key informants described improvements in the climate of academic medicine for women as modest. Medical schools were noted to vary by department in the gender experience of women, often with no institutional oversight. Our findings speak to the need for systematic review by medical schools and by accrediting organizations to achieve gender equity in academic medicine.

An innovative longitudinal curriculum to increase emergency medicine residents’ exposure to rarely encountered and technically challenging procedures

Directory of Open Access Journals (Sweden)

Grall KH

2014-07-01

Full Text Available Kristi H Grall,1 Lisa R Stoneking,1 Lawrence A DeLuca,1 Anna L Waterbrook,1 T Gail Pritchard,2,3 Kurt R Denninghoff1 1Department of Emergency Medicine, The College of Medicine, The University of Arizona, 2Office Medical Student Education, 3Office of Graduate Medical Education, The College of Medicine, The University of Arizona, Tucson, AZ, USA Background: Procedural skills have historically been taught at the bedside. In this study, we aimed to increase resident knowledge of uncommon emergency medical procedures to increase residents’ procedural skills in common and uncommon emergency medical procedures and to integrate cognitive training with hands-on procedural instruction using high- and low-fidelity simulation. Methods: We developed 13 anatomically/physiologically-based procedure modules focusing on uncommon clinical procedures and/or those requiring higher levels of technical skills. A departmental expert directed each session with collaboration from colleagues in related subspecialties. Sessions were developed based on Manthey and Fitch’s stages of procedural competency including 1 knowledge acquisition, 2 experience/technical skill development, and 3 competency evaluation. We then distributed a brief, 10-question, online survey to our residents in order to solicit feedback regarding their perceptions of increased knowledge and ability in uncommon and common emergency medical procedures, and their perception of the effectiveness of integrated cognitive training with hands-on instruction through high- and low-fidelity simulation. Results: Fifty percent of our residents (11/22 responded to our survey. Responses indicated the procedure series helped with understanding of both uncommon (65% strongly agreed [SA], 35% agreed [A] and common (55% SA, 45% A emergency medicine procedures and increased residents’ ability to perform uncommon (55% SA, 45% A and common (45% SA, 55% A emergency medical procedures. In addition, survey results

Works Technical Department progress report, March 1961

Energy Technology Data Exchange (ETDEWEB)

None

1961-04-19

This document details the activities of the Savannah River Works Technical Department during the month of March 1961. Topics discussed are: Reactor Technology, Separations Technology, Engineering Assistance, Health Physics, Laboratories Overview, and Technical Papers Issued.

[Progress in precision medicine: a scientific perspective].

Science.gov (United States)

Wang, B; Li, L M

2017-01-10

Precision medicine is a new strategy for disease prevention and treatment by taking into account differences in genetics, environment and lifestyles among individuals and making precise diseases classification and diagnosis, which can provide patients with personalized, targeted prevention and treatment. Large-scale population cohort studies are fundamental for precision medicine research, and could produce best evidence for precision medicine practices. Current criticisms on precision medicine mainly focus on the very small proportion of benefited patients, the neglect of social determinants for health, and the possible waste of limited medical resources. In spite of this, precision medicine is still a most hopeful research area, and would become a health care practice model in the future.

[Research progress in root rot diseases of Chinese herbal medicine and control strategy by antagonistic microorganisms].

Science.gov (United States)

Gao, Fen; Ren, Xiao-xia; Wang, Meng-liang; Qin, Xue-mei

2015-11-01

In recent years, root rot diseases of Chinese herbal medicine have been posing grave threat to the development of the traditional Chinese medicine industry. This article presents a review on the occurring situation of the root rot disease, including the occurrence of the disease, the diversity of the pathogens, the regional difference in dominant pathogens,and the complexity of symptoms and a survey of the progress in bio-control of the disease using antagonistic microorganisms. The paper also discusses the existing problems and future prospects in the research.

Radiation physics in medicine and veterinary medicine studies

International Nuclear Information System (INIS)

Popovic, D.; Djuric, G.

2000-01-01

Medical and veterinary medicine staff and specialists represent an important decision making group in national administration and institutions dealing with radiation protection and environmental protection matters in general. Still, their education in physics, especially in radiation physics is fragmentary and loose, both from technical and theoretical point of view. Within medicine and veterinary medicine studies as well as within other biomedical sciences (biology, pharmacology, biotechnology) radiation physics is usually incorporated in the first year curricula as a part of general physics or biophysics course. Some segments of radiation physics mainly as a technical base for different instrumentation methods and techniques could be also found within different graduate and post-graduate courses of radiology, physical therapy, radiation hygiene, environmental protection, etc. But the traditional approach in presenting the matter and inflexibility of the educational system strongly confront the growing public concern for the environmental problems dealing with radiation and demands for better informing and technical education for those involved in informing and administration. This paper considers some of these problems presenting a new approach in education in radiation physics for medical and veterinary medicine students based on education through student projects and work in the field, as well as on the strong collaboration among administration, universities and professional societies on the national and international level. (author)

Progress of research in treatment of hyperlipidemia by monomer or compound recipe of Chinese herbal medicine.

Science.gov (United States)

Dou, Xiao-bing; Wo, Xing-de; Fan, Chun-lei

2008-03-01

Hyperlipidemia (HLP) is the No.1 risk factor for patients with atherosclerosis (AS) and is directly related to the occurrence of coronary artery disease (CAD) and cerebrovascular disease. Therefore, prevention and treatment of AS is of great importance and of practical significance in controlling the incidence and mortality of CAD. With its peculiar syndrome-dependent therapy, traditional Chinese medicine (TCM) has accumulated abundant practical experiences in this field and good clinical effects have been achieved. Chinese herbal medicine, with its particularly unique advantages and high potentials yet to be tapped, displays its huge strength in HLP prevention and treatment. The progress of studies concerning prevention and treatment of HLP by Chinese herbal medicines, in the form of monomers or compound recipes, is reviewed in this paper.

[Research progress of genetic engineering on medicinal plants].

Science.gov (United States)

Teng, Zhong-qiu; Shen, Ye

2015-02-01

The application of genetic engineering technology in modern agriculture shows its outstanding role in dealing with food shortage. Traditional medicinal plant cultivation and collection have also faced with challenges, such as lack of resources, deterioration of environment, germplasm of recession and a series of problems. Genetic engineering can be used to improve the disease resistance, insect resistance, herbicides resistant ability of medicinal plant, also can improve the medicinal plant yield and increase the content of active substances in medicinal plants. Thus, the potent biotechnology can play an important role in protection and large area planting of medicinal plants. In the development of medicinal plant genetic engineering, the safety of transgenic medicinal plants should also be paid attention to. A set of scientific safety evaluation and judgment standard which is suitable for transgenic medicinal plants should be established based on the recognition of the particularity of medicinal plants.

Inadequate Progress for Women in Academic Medicine: Findings from the National Faculty Study

Science.gov (United States)

Gunn, Christine M.; Kaplan, Samantha A.; Raj, Anita; Freund, Karen M.

2015-01-01

Abstract Background: Women have entered academic medicine in significant numbers for 4 decades and now comprise 20% of full-time faculty. Despite this, women have not reached senior positions in parity with men. We sought to explore the gender climate in academic medicine as perceived by representatives to the Association of American Medical Colleges (AAMC) Group on Women in Medicine and Science (GWIMS) and Group on Diversity and Inclusion (GDI). Methods: We conducted a qualitative analysis of semistructured telephone interviews with GWIMS and GDI representatives and other senior leaders at 24 randomly selected medical schools of the 1995 National Faculty Study. All were in the continental United States, balanced for public/private status and AAMC geographic region. Interviews were audiotaped, transcribed, and organized into content areas before an inductive thematic analysis was conducted. Themes that were expressed by multiple informants were studied for patterns of association. Results: Five themes were identified: (1) a perceived wide spectrum in gender climate; (2) lack of parity in rank and leadership by gender; (3) lack of retention of women in academic medicine (the “leaky pipeline”); (4) lack of gender equity in compensation; and (5) a disproportionate burden of family responsibilities and work-life balance on women's career progression. Conclusions: Key informants described improvements in the climate of academic medicine for women as modest. Medical schools were noted to vary by department in the gender experience of women, often with no institutional oversight. Our findings speak to the need for systematic review by medical schools and by accrediting organizations to achieve gender equity in academic medicine. PMID:25658907

Nuclear structure theory. Annual technical progress report, October 1, 1976--September 30, 1977

International Nuclear Information System (INIS)

French, J.B.; Koltun, D.S.

1977-01-01

This report summarizes progress during the past year in the following areas of nuclear structure and reaction theory: (1) statistical spectroscopy, including giant resonances for beta and electromagnetic excitation and sum rules (including inverse-energy-weighted sum rules), statistical methods of truncating shell model spaces and renormalization of operators, study of state labelling and ''chains'' of groups, evaluation of fluctuation measures, technical aspects of operator averaging; (2) meson interactions with nuclei, including scattering and absorption of mesons by nuclei (general methods), models for absorption, single- and double-charge exchange of pions, role of rho mesons

FY 1992 work plan and technical progress reports

Energy Technology Data Exchange (ETDEWEB)

NONE

1992-11-01

The Desert Research Institute (DRI) is a division of the University of Nevada System devoted to multidisciplinary scientific research. For more than 25 years, DRI has conducted research for the US Department of Energy`s Nevada Field Office (DOE/NV) in support of operations at the Nevada Test Site (NTS). During that time, the research program has grown from an early focus on hydrologic studies to include the areas of geology, archaeology, environmental compliance and monitoring, statistics, database management, public education, and community relations. The range of DRI`s activities has also expanded to include a considerable amount of management and administrative support in addition to scientific investigations. DRI`s work plan for FY 1992 reflects a changing emphasis in DOE/NV activities from nuclear weapons testing to environmental restoration and monitoring. Most of the environmental projects from FY 1991 are continuing, and several new projects have been added to the Environmental Compliance Program. The Office of Technology Development Program, created during FY 1991, also includes a number of environmental projects. This document contains the FY 1992 work plan and quarterly technical progress reports for each DRI project.

Recent progress of research on medicinal mushrooms, foods, and other herbal products used in traditional Chinese medicine

Directory of Open Access Journals (Sweden)

Kuo-Hsiung Lee

2012-04-01

Full Text Available This article will review selected herbal products used in traditional Chinese medicine, including medicinal mushrooms (巴西蘑菇 bā xī mó gū; Agaricus blazei, 雲芝 yún zhī; Coriolus versicolor, 靈芝 líng zhī; Ganoderma lucidum, 香蕈 xiāng xùn; shiitake, Lentinus edodes, 牛樟芝 niú zhāng zhī; Taiwanofungus camphoratus, Cordyceps (冬蟲夏草 dōng chóng xià cǎo, pomegranate (石榴 shí liú; Granati Fructus, green tea (綠茶 lǜ chá; Theae Folium Non Fermentatum, garlic (大蒜 dà suàn; Allii Sativi Bulbus, turmeric (薑黃 jiāng huáng; Curcumae Longae Rhizoma, and Artemisiae Annuae Herba (青蒿 qīng hāo; sweet wormwood. Many of the discussed herbal products have gained popularity in their uses as dietary supplements for health benefits. The review will focus on the active constituents of the herbs and their bioactivities, with emphasis on the most recent progress in research for the period of 2003 to 2011.

Narrative Based Medicine and Neonatology: an interpretative approach

Directory of Open Access Journals (Sweden)

Massimiliano Zonza

2012-10-01

Full Text Available The use of Evidence Based Medicine (EBM has progressively lead doctors to focus their practice on the disease and not on the patient anymore. They consider a sick body or a sick part rather than a sick person. Such an attitude results in a progressive process of alienation or “unauthentic experience”. On the contrary the Medical Humanities represents a strong reaction to this state of things, and for Medicine a chance to embrace again its humanistic “vocation”. Narrative Based Medicine (NBM places at the center of the clinical practice the communicative and relational dimension. This study deepen the application of NBM to the scope of neonatal care. As a result of our work, we have identified in the NBM applied to the neonatal area a fundamental characteristic, the Neonatal Triangle (doctors, patient, parents, and a triple functionality (diagnostic, ethical and educational placed in three different ideal chronological moments (before, during and after. We explore the close connection between these functions and the clinical work and how the NBM model, through these same functions, enhance the opportunity of care and relationship. The main assumption is obviously the Doctors ability to build a shared narrative relation with the Parents of the little Patients, that in the technical terms of the Narrative Based Medicine is called co-construction of the illness history. We can remark that with the NBM we understand (the narrative frame, build (the therapeutic alliance and share (decisions.

Final Technical Progress Report: Development of Low-Cost Suspension Heliostat; December 7, 2011 - December 6, 2012

Energy Technology Data Exchange (ETDEWEB)

Bender, W.

2013-01-01

Final technical progress report of SunShot Incubator Solaflect Energy. The project succeeded in demonstrating that the Solaflect Suspension Heliostat design is viable for large-scale CSP installations. Canting accuracy is acceptable and is continually improving as Solaflect improves its understanding of this design. Cost reduction initiatives were successful, and there are still many opportunities for further development and further cost reduction.

New imaging systems in nuclear medicine. Technical progress report, January 1, 1985-November 1, 1985

International Nuclear Information System (INIS)

Brownell, G.L.

1985-01-01

Developments of improved imaging systems in nuclear medicine are reported with emphasis on development of positron emission tomographs that combine high resolution, with high sensitivity and high count rate capability. A second generation cylindrical analog positron camera design has provided excellent light collection with limited light spread, characteristics needed for high spatial and temporal resolution. Other aspects of the camera development include the design of associated electronics, and provision for data storage and processing. Utilizing the above camera basic studies have been performed to evaluate blood flow in the cat brain stem during auditory stimulation, ventilation in the dog using 13 N and blood flow in the canine heart. 2 refs., 2 figs

Generation and focusing of pulsed intense ion beams. Technical progress report, 20 August 1981-30 September 1982

International Nuclear Information System (INIS)

Hammer, D.A.; Kusse, B.R.; Sudan, R.N.

1983-07-01

The progress on this contract is described in two parts. The first deals with the technical operation of the LION accelerator which is the exact equivalent to one line of PBFA-I. The second part is concerned with the experimental results on the ion diode mounted at the front end of the LION accelerator

The U.S. nuclear waste management program - technical progress at Yucca Mountain

Energy Technology Data Exchange (ETDEWEB)

Barrett, L.H. [U.S. Department of Energy (United States)

2001-07-01

This paper discusses the current status of a national program being developed by the U.S. Department of Energy for the management of spent nuclear fuel and high-level radioactive waste produced by civilian nuclear power generation and defense-related activities. In 1987 the U.S. Congress directed the Department to characterize the Yucca Mountain site in Nevada and determine its suitability for development of a geologic repository. This paper will focus on the technical progress that has been made after more than 15 years of scientific and engineering investigations at Yucca Mountain, and the remaining work that is being done to support a decision on whether to recommend the site for development of a geologic repository. (author)

[Research progress of Chinese herbal medicine and traditional Chinese medicine resulting in liver injury].

Science.gov (United States)

Wang, Jingli; Zhou, Chaofan

2011-12-01

The adverse reactions caused by Chinese herbal medicine and traditional Chinese medicine are reported increased in recent years, among which the acute liver injury caused by Chinese herbal medicine accounts for 21.5% of total liver injuries. Despite the misuse of traditional Chinese medicine not in accordance with differentiation of symptoms and signs, the adverse reaction of Chinese herbal medicine itself can't be little to these adverse events. The paper summarizes the most common categories of traditional Chinese medicine resulting in liver injury, the mechanism, pathological characteristics, clinical symptom of liver injury, the reasons of the reaction and how to prevent. The research aims to enhance the clinical physician recognition of liver injury caused by Chinese herbal medicine, in order to ensure the safe and rational usage of traditional Chinese medicine.

Precision medicine, an approach for development of the future medicine technologies

Directory of Open Access Journals (Sweden)

Iraj Nabipour

2016-04-01

Full Text Available Precision medicine is an approach in medicine that takes into account individual differences in people's genes, environments, and lifestyle. This field of medicine redefines our understanding of disease onset and progression, treatment response, and health outcomes through the more precise measurement of molecular, environmental, and behavioral factors that contribute to health and disease. Undoubtedly, the advances in omics technologies including genomics, data collection and storage, computational analysis, and mobile health applications over the last decade produced significant progress for precision medicine. In fact, precision medicine is a platform for the growth of personalized medicine, wearable biosensors, mobile health, computational sciences, genomic singularity, and other omics technologies. In the pathway of precision medicine, mathematics and computational sciences will be revolutionized to overcome the challenges in Big Data. By the birth of precision medicine, novel therapeutic strategies for chronic complex diseases such as cardiovascular disease and cancers would be designed in Systems Medicine.

Progress in organizing national and international comparisons for nuclear medicine measurements

International Nuclear Information System (INIS)

Sahagia, Maria; Waetjen, Anamaria C.; Ivan, Constantin

2008-01-01

The paper presents the progress registered by the Radionuclide Metrology Laboratory (RML) from IFIN-HH, in improvement of the quality of radiopharmaceuticals activity measurement, and assurance of the whole traceability chain from international level to the national users. The progress in organization of comparisons for radiopharmaceuticals activity measurement is analyzed. A detailed description of two recent national comparisons, and an international one, regarding 131 I solutions, within the frame of the IAEA's CRP E2.10.05 'Harmonization of quality practices for nuclear medicine radioactivity measurements' is done, with the analysis of the strong and week points in measurements. The most important outcome of the paper is the analysis of the evolution in quality of comparisons since a previously reported one. At the RML level, the improvements are: demonstration of the international equivalence of primary Romanian activity standard, improvement of the secondary standard, relevance of the comparison within the IAEA frame, implementation of a quality system in standardization and in comparisons, and implication of the RML in calibrations and metrological checks. The participants' reported improvements refer to growing of the awareness in quality of measurement and improvement of the measurement equipment. Reasons for future comparisons organization are presented. (author)

[Establishing the idea of holistic integrative medicine, optimizing the quality of health care service in prevention and treatment].

Science.gov (United States)

Sun, Xing-guo

2015-07-01

Under background of reductionism in the modern science, physiology and medicine are stepwise refined into system, organ, disease, cell and gene etc. Although clinical medicine, only service in whole human object, obviously brought tremendous progress, it also appeared obvious defects and limits at the same time. Professionalized and specialized medicine not only needs to be integrated from basics to clinical fields, but also from prevention, health management, clinical treatment and functional rehabilitation medicine. People are indivisible organic whole. Professionalization, translation and integration must be combined. In order to provide the best quality and optimized medical service for the Chinese people and to lead in the world, we have to strengthen professional and technical knowledge, and have to establish the holistic integrative medical philosophy for physiology and medicine too.

The Development of K-8 Progress Monitoring Measures in Mathematics for Use with the 2% and General Education Populations: Kindergarten. Technical Report # 0921

Science.gov (United States)

Alonzo, Julie; Tindal, Gerald

2009-01-01

In this technical report, we describe the development and piloting of a series of mathematics progress monitoring measures intended for use with students in kindergarten. These measures, available as part of easyCBM[TM], an online progress monitoring assessment system, were developed in 2008 and administered to approximately 2800 students from…

Decontamination Systems Information and Research Program. Quarterly technical progress report, January 1--March 31, 1993

Energy Technology Data Exchange (ETDEWEB)

1993-04-01

This reports reports the progress/efforts performed on six technical projects: 1. systematic assessment of the state of hazardous waste clean-up technologies; 2. site remediation technologies (SRT):drain- enhanced soil flushing for organic contaminants removal; 3. SRT: in situ bio-remediation of organic contaminants; 4. excavation systems for hazardous waste sites: dust control methods for in-situ nuclear waste handling; 5. chemical destruction of polychlorinated biphenyls; and 6. development of organic sensors: monolayer and multilayer self-assembled films for chemical sensors.

Nuclear medicine and imaging research: instrumentation and quantitative methods of evaluation. Comprehensive progress report, January 1, 1980-January 14, 1983

International Nuclear Information System (INIS)

Beck, R.N.; Cooper, M.C.

1982-07-01

Progress is reported for the period January 1980 through January 1983 in the following project areas: (1) imaging systems in nuclear medicine and image evaluation; and (2) methodology for quantitative evaluation of diagnostic performance

Developing a programme on molecular nuclear medicine. Proceedings of a technical meeting

International Nuclear Information System (INIS)

2007-07-01

been increasingly applied for revealing the different profiles of normal and affected cells or tissues and also for the following-up treatment of certain diseases like minimal residual disease (MRD). The detection of changes in the level of transcription of certain genes using this approach has been a useful tool for the early detection of disease, improving the patient survival. At the Technical Meeting on Developing a Medium to Long Term Programme on Molecular Nuclear Medicine, held in Vienna, 29 November - 1 December 2004, certain areas were selected as the best candidates to be included in the IAEA's programme in relation to their applicability and potential to improve human health. The IAEA will continue supporting training activities and fellowships, and encouraging developing Member States to take advantage of the use of isotopic advanced molecular techniques for the resolution of their health problems. This TECDOC contains useful information for health workers in the nuclear medicine and molecular biology fields. Previous IAEA publications, Nuclear Medicine Resources Manual (STI/PUB/1198), Radionuclides in Molecular Technology for Diagnosis of Communicable Diseases (IAEA-TECDOC-748), In Vitro Radionuclide Techniques in Medical Diagnosis (IAEA-TECDOC-1001) and Organization of a Radioisotope Based Molecular Biology Laboratory (IAEA-TECDOC-1528), are separately focused on nuclear medicine and molecular biology techniques applied to human diseases, while the present publication provides presentations on the advances of molecular nuclear medicine techniques

Epistemology, Ethics, and Progress in Precision Medicine.

Science.gov (United States)

Hey, Spencer Phillips; Barsanti-Innes, Brianna

2016-01-01

The emerging paradigm of precision medicine strives to leverage the tools of molecular biology to prospectively tailor treatments to the individual patient. Fundamental to the success of this movement is the discovery and validation of "predictive biomarkers," which are properties of a patient's biological specimens that can be assayed in advance of therapy to inform the treatment decision. Unfortunately, research into biomarkers and diagnostics for precision medicine has fallen well short of expectations. In this essay, we examine the portfolio of research activities into the excision repair cross complement group 1 (ERCC1) gene as a predictive biomarker for precision lung cancer therapy as a case study in elucidating the epistemological and ethical obstacles to developing new precision medicines.

Nuclear Medicine Program progress report for quarter ending June 30, 1993

Energy Technology Data Exchange (ETDEWEB)

Knapp, F.F. Jr.; Ambrose, K.R.; Beets, A.L.; Callahan, A.P.; Hsieh, B.T.; McPherson, D.W.; Mirzadeh, S.; Lambert, C.R.

1993-07-01

The ``IQNP`` agent is an antagonist for the cholinergic-muscarinic receptor. Since the IQNP molecule has two asymmetric centers and either cis or trans isomerism of the vinyl iodide, there are eight possible isomeric combinations. In this report, the systematic synthesis, purification and animal testing of several isomers of radioiodinated ``IQNP`` are reported. A dramatic and unexpected relation between the absolute configuration at the two asymmetric centers and the stereochemistry of the vinyl iodide on receptor specificity was observed. The E-(R)(R) isomer shows specific and significant localization (per cent dose/gram at 6 hours) in receptor-rich cerebral structures (i.e. Cortex = 1.38 + 0.31; Striatum = 1.22 + 0.20) and low uptake in tissues rich in the M{sub 2} subtype (Heart = 0.10; Cerebellum = 0.04). In contrast, the E-(R)(S) isomer shows very low receptor-specific uptake (Cortex = 0.04; Striatum = 0.02), demonstrating the importance of absolute configuration at the acetate center. An unexpected and important observation is that the stereochemistry of the vinyl iodine appears to affect receptor subtype specificity, since the Z-(R,S)(R) isomer shows much higher uptake in the heart (0.56 + 0.12) and cerebellum (0.17 + 0.04). Studies are now in progress to confirm these exciting results in vitro. Progress has also continued during this period with several collaborative programs. The first large-scale clinical tungsten-188/rhenium-188 generator prototype (500 mCi) was fabricated and supplied to the Center for Molecular Medicine and Immunology (CMMI), in Newark, New Jersey, for Phase I clinical trials of rhenium-188-labeled anti CEA antibodies for patient treatment. Collaborative studies are also continuing in conjunction with the Nuclear Medicine Department at the University of Massachusetts where a generator is in use to compare the biological properties of {open_quotes}direct{close_quotes} and {open_quotes}indirect{close_quotes} labeled antibodies.

GPHS-RTGs in support of the Cassini Mission. Semi annual technical progress report, 1 April 1996--29 September 1996

International Nuclear Information System (INIS)

1996-01-01

This technical progress report discusses work on the Radioisotope Generators and Ancillary Activities for the Cassini spacecraft. The Cassini spacecraft is expected to launch in October 1997, and will explore Saturn and its moons. This progress report discusses issues in: spacecraft integration and liason, engineering support, safety, qualified unicouple fabrication, ETG fabrication and testing, ground support equipment, RTG shipping and launch support, designs, reviews and mission application. Safety analysis of the RTGs during reentry and launch accidents are covered. This report covers the period of April 1 to September 29, 1996

Technical reliability of geological disposal for high-level radioactive wastes in Japan. The second progress report. Part 1. Geological environment of Japan

Energy Technology Data Exchange (ETDEWEB)

NONE

1999-11-01

Based on the Advisory Committee Report on Nuclear Fuel Cycle Backend Policy submitted to the Japanese Government in 1997, JNC documents the progress of research and development program in the form of the second progress report (the first one published in 1992). It summarizes an evaluation of the technical reliability and safety of the geological disposal concept for high-level radioactive wastes (HLW) in Japan. The present document, the part 1 of the progress report, describes first in detail the role of geological environment in high-level radioactive wastes disposal, the features of Japanese geological environment, and programs to proceed the investigation in geological environment. The following chapter summarizes scientific basis for possible existence of stable geological environment, stable for a long period needed for the HLW disposal in Japan including such natural phenomena as volcano and faults. The results of the investigation of the characteristics of bed-rocks and groundwater are presented. These are important for multiple barrier system construction of deep geological disposal. The report furthermore describes the present status of technical and methodological progress in investigating geological environment and finally on the results of natural analog study in Tono uranium deposits area. (Ohno, S.)

Index to Nuclear Safety: a technical progress review by chronology, permuted title, and author. Vol. 11(1)--Vol. 18(6)

Energy Technology Data Exchange (ETDEWEB)

Cottrell, W.B.; Klein, A.

1978-04-11

This index to Nuclear Safety covers articles published in Nuclear Safety, Vol. 11, No. 1 (January-February 1970), through Vol. 18, No. 6 (November-December 1977). It is divided into three sections: a chronological list of articles (including abstracts) followed by a permuted-title (KWIC) index and an author index. Nuclear Safety, a bimonthly technical progress review prepared by the Nuclear Safety Information Center (NSIC), covers all safety aspects of nuclear power reactors and associated facilities. Over 450 technical articles published in Nuclear Safety in the last eight years are listed in this index.

Index to Nuclear Safety: a technical progress review by chronology, permuted title, and author. Vol. 11(1)--Vol. 18(6)

International Nuclear Information System (INIS)

Cottrell, W.B.; Klein, A.

1978-01-01

This index to Nuclear Safety covers articles published in Nuclear Safety, Vol. 11, No. 1 (January-February 1970), through Vol. 18, No. 6 (November-December 1977). It is divided into three sections: a chronological list of articles (including abstracts) followed by a permuted-title (KWIC) index and an author index. Nuclear Safety, a bimonthly technical progress review prepared by the Nuclear Safety Information Center (NSIC), covers all safety aspects of nuclear power reactors and associated facilities. Over 450 technical articles published in Nuclear Safety in the last eight years are listed in this index

[Practice of Internal Medicine in Latin America. Role of the internist].

Science.gov (United States)

Varela, Nacor

2002-01-01

This article explores the causes of the crisis in the role of internists. As in the United States, the progressive specialization of internists lead to a dehumanized, expensive and technical practice of medicine. Aiming to better incomes and prestige, more than 60% of internists practice as specialists. Primary care physicians, with a very low rate of problem solving, cover 75% of consultations. Specialists, with increasing costs, cover the rest of consultations. Patients, medical schools and health organizations are claiming the return of the general internal medicine specialist. To increase the interest for general internal medicine, several strategies are applicable. Medical students interested in general internal medicine could receive a focused training, provided by these specialists. A greater emphasis should be put on primary care. More independent, secondary care diagnostic and treatment centers, should be created. Continuous medical education should be done with periodical re certification of physicians. The public health system should increase its wages and the generalist view should be maintained by physicians when practicing at their private offices.

The Development of K-8 Progress Monitoring Measures in Mathematics for Use with the 2% and General Education Populations: Grade 1. Technical Report # 0919

Science.gov (United States)

Alonzo, Julie; Tindal, Gerald

2009-01-01

In this technical report, we describe the development and piloting of a series of mathematics progress monitoring measures intended for use with students in grade 1. These measures, available as part of easyCBM [TM], an online progress monitoring assessment system, were developed in 2008 and administered to approximately 2800 students from schools…

The Development of K-8 Progress Monitoring Measures in Mathematics for Use with the 2% and General Education Populations: Grade 2. Technical Report # 0920

Science.gov (United States)

Alonzo, Julie; Lai, Cheng Fei; Tindal, Gerald

2009-01-01

In this technical report, we describe the development and piloting of a series of mathematics progress monitoring measures intended for use with students in grades kindergarten through eighth grade. These measures, available as part of easyCBM[TM], an online progress monitoring assessment system, were developed in 2007 and 2008 and administered to…

The Development of K-8 Progress Monitoring Measures in Mathematics for Use with the 2% and General Education Populations: Grade 7. Technical Report 0908

Science.gov (United States)

Lai, Cheng Fei; Alonzo, Julie; Tindal, Gerald

2009-01-01

In this technical report, we describe the development and piloting of a series of mathematics progress monitoring measures intended for use with students in grades kindergarten through eighth grade. These measures, available as part of easyCBM[TM], an online progress monitoring assessment system, were developed in 2007 and 2008 and administered to…

Technical reliability of geological disposal for high-level radioactive wastes in Japan. The second progress report. Introductory part and summaries

International Nuclear Information System (INIS)

1999-11-01

Based on the Advisory Committee Report on Nuclear Fuel Cycle Backend Policy submitted to the Japanese Government in 1997, JNC documents the progress of research and development program in the form of the second progress report (the first one published in 1992). It summarizes an evaluation of the technical reliability and safety of the geological disposal concept for high-level radioactive wastes (HLW) in Japan and comprises seven chapters. Chapter I briefly describes the importance of HLW management in promoting nuclear energy utilization. According to the long-term program, the HLW separated from spent fuels at reprocessing plants is to be vitrified and stored for a period of 30 to 50 years to allow cooling, then be disposed of in a deep geological formation. Chapter II mainly explains the concepts of geological disposal in Japan. Chapters III to V are devoted to discussions on three important technical elements (the geological environment of Japan, engineering technology and safety assessment of the geological disposal system) which are necessary for reliable realization of the geological disposal concept. Chapter VI demonstrates the technical ground for site selection and for setup of safety standards of the disposal. Chapter VII summarizes together with plans for future research and development. (Ohno, S.)

Progresso tecnico, forme di mercato e disoccupazione. ( Technical progress, market forms and unemployment

Directory of Open Access Journals (Sweden)

A. ASIMAKOPULOS A.

2013-12-01

Full Text Available Lo scopo del presente lavoro è triplice . Il primo obiettivo è quello di sottolineare l'importanza delle intuizioni da trovare nel lavoro di Sylos Labini . Il secondo scopo è quello di espandere su di essa distinguendo tra i diversi tipi di progresso tecnico . Infine , il terzo obiettivo è quello di commentare il confronto di Labini di Ricardo e Keynes sulla possibilità di disoccupazione tecnologica . Per quanto riguarda la sua descrizione del progresso tecnologico come " risparmio di lavoro " , l'autore mostra che una descrizione più completa sarebbe più utile per i suoi scopiThe purpose of the present paper is threefold. The first purpose is to emphasise the importance of the insights to be found in Sylos Labini’s work. The second purpose is to expand upon it by distinguishing  between the different types of technical progress. Finally, the third purpose is to comment on Labini’s comparison of Ricardo and Keynes on the possibility of technological unemployment. Regarding his description of technological progress as “labour saving”, the author shows that a more comprehensive description would be more useful for his purposes.JEL: E24, J64, O33

Technical progress and efficiency changes in football teams participating in the UEFA Champions League

Directory of Open Access Journals (Sweden)

Lucía Isabel García Cebrián

2015-09-01

Full Text Available This paper commits to calculate and analyze productivy levels and its components for teams that participated in the UEFA Champions League between 2003 and 2012. It will pursue three objectives: 1 evaluate resources usage, 2 analyze the productivity levels of the football teams and the sports results, and 3 see the influence of participation experience in reference to productivity and sports results. Using Malmquist Productivity Index, the results reflect a lack of consistent progression of efficiency, productivity, and technical change. This competition does not reward the efficient usage of resources and there is not a conclusive relationshop between permanence in the competition and productivity.

Volatiles combustion in fluidized beds. Technical progress report, 4 March 1993--3 June 1993

Energy Technology Data Exchange (ETDEWEB)

Hesketh, R.P.

1993-09-01

The goal of this project is to investigate the conditions in which volatiles will burn within both the dense and freeboard regions of fluidized beds. Experiments using a fluidized bed operated at incipient fluidization will be performed to characterize the effect of particle surface area, initial fuel concentration, and particle type on the inhibition of volatiles within a fluidized bed. The work conducted during the period 4 March, 1993 through 3 June, 1993 is reported in this technical progress report. The work during this time period consists primarily of the startup and trouble shooting of the fluidized bed reactor and gas phase modeling of methane and propane.

Writing a technical note.

Science.gov (United States)

Ng, K H; Peh, W C G

2010-02-01

A technical note is a short article giving a brief description of a specific development, technique or procedure, or it may describe a modification of an existing technique, procedure or device applicable to medicine. The technique, procedure or device described should have practical value and should contribute to clinical diagnosis or management. It could also present a software tool, or an experimental or computational method. Technical notes are variously referred to as technical innovations or technical developments. The main criteria for publication will be the novelty of concepts involved, the validity of the technique and its potential for clinical applications.

Converting energy to medical progress [nuclear medicine

Energy Technology Data Exchange (ETDEWEB)

NONE

2001-04-01

For over 50 years the Office of Biological and Environmental Research (BER) of the United States Department of Energy (DOE) has been investing to advance environmental and biomedical knowledge connected to energy. The BER Medical Sciences program fosters research to develop beneficial applications of nuclear technologies for medical diagnosis and treatment of many diseases. Today, nuclear medicine helps millions of patients annually in the United States. Nearly every nuclear medicine scan or test used today was made possible by past BER-funded research on radiotracers, radiation detection devices, gamma cameras, PET and SPECT scanners, and computer science. The heart of biological research within BER has always been the pursuit of improved human health. The nuclear medicine of tomorrow will depend greatly on today's BER-supported research, particularly in the discovery of radiopharmaceuticals that seek specific molecular and genetic targets, the design of advanced scanners needed to create meaningful images with these future radiotracers, and the promise of new radiopharmaceutical treatments for cancers and genetic diseases.

Converting energy to medical progress [nuclear medicine

International Nuclear Information System (INIS)

2001-01-01

For over 50 years the Office of Biological and Environmental Research (BER) of the United States Department of Energy (DOE) has been investing to advance environmental and biomedical knowledge connected to energy. The BER Medical Sciences program fosters research to develop beneficial applications of nuclear technologies for medical diagnosis and treatment of many diseases. Today, nuclear medicine helps millions of patients annually in the United States. Nearly every nuclear medicine scan or test used today was made possible by past BER-funded research on radiotracers, radiation detection devices, gamma cameras, PET and SPECT scanners, and computer science. The heart of biological research within BER has always been the pursuit of improved human health. The nuclear medicine of tomorrow will depend greatly on today's BER-supported research, particularly in the discovery of radiopharmaceuticals that seek specific molecular and genetic targets, the design of advanced scanners needed to create meaningful images with these future radiotracers, and the promise of new radiopharmaceutical treatments for cancers and genetic diseases

The Development of K-8 Progress Monitoring Measures in Mathematics for Use with the 2% and General Education Populations: Grade 3. Technical Report # 09-02

Science.gov (United States)

Alonzo, Julie; Lai, Cheng Fei; Tindal, Gerald

2009-01-01

In this technical report, we describe the development and piloting of a series of mathematics progress monitoring measures intended for use with students in grades kindergarten through eighth grade. These measures, available as part of easyCBM[TM], an online progress monitoring assessment system, were developed in 2007 and 2008 and administered to…

The Development of K-8 Progress Monitoring Measures in Mathematics for Use with the 2% and General Education Populations: Grade 5. Technical Report # 09-01

Science.gov (United States)

Lai, Cheng Fei; Alonzo, Julie; Tindal, Gerald

2009-01-01

In this technical report, we describe the development and piloting of a series of mathematics progress monitoring measures intended for use with students in grades kindergarten through eighth grade. These measures, available as part of easyCBM[TM], an online progress monitoring assessment system, were developed in 2007 and 2008 and administered to…

The Development of K-8 Progress Monitoring Measures in Mathematics for Use with the 2% and General Education Populations: Grade 4. Technical Report # 09-03

Science.gov (United States)

Alonzo, Julie; Lai, Cheng Fei; Tindal, Gerald

2009-01-01

In this technical report, we describe the development and piloting of a series of mathematics progress monitoring measures intended for use with students in grades kindergarten through eighth grade. These measures, available as part of easyCBM[TM], an online progress monitoring assessment system, were developed in 2007 and 2008 and administered to…

The Development of K-8 Progress Monitoring Measures in Mathematics for Use with the 2% and General Education Populations: Grade 8. Technical Report # 09-04

Science.gov (United States)

Lai, Cheng Fei; Alonzo, Julie; Tindal, Gerald

2009-01-01

In this technical report, we describe the development and piloting of a series of mathematics progress monitoring measures intended for use with students in grades kindergarten through eighth grade. These measures, available as part of easyCBM[TM], an online progress monitoring assessment system, were developed in 2007 and 2008 and administered to…

National Council on Radiation Protection and Measurements semiannual technical progress report, March 1989--August 1989

International Nuclear Information System (INIS)

Ney, W.R.

1991-01-01

This semiannual technical progress report is for the period 1 March 1989 through 31 August 1989. This National Council on Radiation Protection and Measurements (NCRP) program is designed to provide recommendations for radiation protection based on scientific principles. During this period several reports were published covering the topics of occupational radiation exposure, medical exposure, radon control, dosimetry, and radiation protection standards. Accomplishments of various committees are also reported; including the committees on dental x-ray protection, radiation safety in uranium mining and milling, ALARA, instrumentation, records maintenance, occupational exposures of medical personnel, emergency planning, and others. (SM)

Index to Nuclear Safety: a technical progress review by chronology, permuted title, and author, Volume 18 (1) through Volume 22 (6)

International Nuclear Information System (INIS)

Cottrell, W.B.; Passiakos, M.

1982-06-01

This index to Nuclear Safety covers articles published in Nuclear Safety, Volume 18, Number 1 (January-February 1977) through Volume 22, Number 6 (November-December 1981). The index is divided into three section: a chronological list of articles (including abstracts), a permuted-title (KWIC) index, and an author index. Nuclear Safety, a bimonthly technical progress review prepared by the Nuclear Safety Information Center, covers all safety aspects of nuclear power reactors and associated facilities. Over 300 technical articles published in Nuclear Safety in the last 5 years are listed in this index

Index to Nuclear Safety: a technical progress review by chronology, permuted title, and author, Volume 18 (1) through Volume 22 (6)

Energy Technology Data Exchange (ETDEWEB)

Cottrell, W.B.; Passiakos, M.

1982-06-01

This index to Nuclear Safety covers articles published in Nuclear Safety, Volume 18, Number 1 (January-February 1977) through Volume 22, Number 6 (November-December 1981). The index is divided into three section: a chronological list of articles (including abstracts), a permuted-title (KWIC) index, and an author index. Nuclear Safety, a bimonthly technical progress review prepared by the Nuclear Safety Information Center, covers all safety aspects of nuclear power reactors and associated facilities. Over 300 technical articles published in Nuclear Safety in the last 5 years are listed in this index.

Predictors of employer satisfaction: technical and non-technical skills.

Science.gov (United States)

Danielson, Jared A; Wu, Tsui-Feng; Fales-Williams, Amanda J; Kirk, Ryan A; Preast, Vanessa A

2012-01-01

Employers of 2007-2009 graduates from Iowa State University College of Veterinary Medicine were asked to respond to a survey regarding their overall satisfaction with their new employees as well as their new employees' preparation in several technical and non-technical skill areas. Seventy-five responses contained complete data and were used in the analysis. Four technical skill areas (data collection, data interpretation, planning, and taking action) and five non-technical skill areas (interpersonal skills, ability to deal with legal issues, business skills, making referrals, and problem solving) were identified. All of the skill area subscales listed above had appropriate reliability (Cronbach's alpha>0.70) and were positively and significantly correlated with overall employer satisfaction. Results of two simultaneous regression analyses indicated that of the four technical skill areas, taking action is the most salient predictor of employer satisfaction. Of the five non-technical skill areas, interpersonal skills, business skills, making referrals, and problem solving were the most important skills in predicting employer satisfaction. Hierarchical regression analysis revealed that all technical skills explained 25% of the variation in employer satisfaction; non-technical skills explained an additional 42% of the variation in employer satisfaction.

Single-purpose nuclear medicine instruments

International Nuclear Information System (INIS)

Boucek, J.

Nuclear medicine requires the most up-to-date specialized technical facilities. The paper underlines the factor of reliability in purpose-designed equipment used for basic examinations. The possibility is also discussed of the automation of standard nuclear medicine instruments

Index to Nuclear Safety. A technical progress review by chronology, permuted title, and author. Vol. 11, No. 1--Vol. 17, No. 6

International Nuclear Information System (INIS)

Cottrell, W.B.; Klein, A.

1977-01-01

This index to Nuclear Safety covers articles in Nuclear Safety Vol. 11, No. 1 (Jan.-Feb. 1970), through Vol. 17, No. 6 (Nov.-Dec. 1976). The index includes a chronological list of articles (including abstract) followed by KWIC and Author Indexes. Nuclear Safety, a bimonthly technical progress review prepared by the Nuclear Safety Information Center, covers all safety aspects of nuclear power reactors and associated facilities. The index lists over 350 technical articles in the last six years of publication

Index to Nuclear Safety. A technical progress review by chronology, permuted title, and author. Vol. 11, No. 1--Vol. 17, No. 6

Energy Technology Data Exchange (ETDEWEB)

Cottrell, W.B.; Klein, A.

1977-02-23

This index to Nuclear Safety covers articles in Nuclear Safety Vol. 11, No. 1 (Jan.-Feb. 1970), through Vol. 17, No. 6 (Nov.-Dec. 1976). The index includes a chronological list of articles (including abstract) followed by KWIC and Author Indexes. Nuclear Safety, a bimonthly technical progress review prepared by the Nuclear Safety Information Center, covers all safety aspects of nuclear power reactors and associated facilities. The index lists over 350 technical articles in the last six years of publication.

A Procedural Skills OSCE: Assessing Technical and Non-Technical Skills of Internal Medicine Residents

Science.gov (United States)

Pugh, Debra; Hamstra, Stanley J.; Wood, Timothy J.; Humphrey-Murto, Susan; Touchie, Claire; Yudkowsky, Rachel; Bordage, Georges

2015-01-01

Internists are required to perform a number of procedures that require mastery of technical and non-technical skills, however, formal assessment of these skills is often lacking. The purpose of this study was to develop, implement, and gather validity evidence for a procedural skills objective structured clinical examination (PS-OSCE) for internal…

Digital Nuclear Medicine

International Nuclear Information System (INIS)

Erickson, J.J.; Rollo, F.D.

1982-01-01

This book is meant ''to provide the most comprehensive presentation of the technical as well as clincial aspects of computerized nuclear medicine''. It covers basic applications, and advice on acquisition and quality control of nuclear medicine computer systems. The book evolved from a series of lectures given by the contributors during the computer preceptorship program at their institution, Vanderbilt University in Nashville

42 CFR 493.1411 - Standard; Technical consultant qualifications.

Science.gov (United States)

2010-10-01

... technical consultant must— (1) (i) Be a doctor of medicine or doctor of osteopathy licensed to practice medicine or osteopathy in the State in which the laboratory is located; and (ii) Be certified in anatomic...; or (2)(i) Be a doctor of medicine, doctor of osteopathy, or doctor of podiatric medicine licensed to...

Progress report : Technical Physics Division

International Nuclear Information System (INIS)

Gopalaraman, C.P.; Deshpande, R.Y.

1978-01-01

The research and development work carried out in the Technical Physics Division of the Bhabha Atomic Research Centre, Bombay, is reported. Some of the achievements are: (1) fabrication of mass spectrometers for heavy water analysis and lithium 6/7 isotope ratio measurement, (2) fabrication of electronic components for mass spectrometers, (3) growing of sodium iodide crystals for radiation detectors, (4) development of sandwich detectors comprising of NaI(Tl) and CaI(Na), (5) fabrication of mass spectrometer type leak detectors and (6) fabrication of the high vacuum components of the vacuum system of the variable energy cyclotron based at Calcutta. (M.G.B.)

[Chinese medicine industry 4.0：advancing digital pharmaceutical manufacture toward intelligent pharmaceutical manufacture].

Science.gov (United States)

Cheng, Yi-Yu; Qu, Hai-Bin; Zhang, Bo-Li

2016-01-01

A perspective analysis on the technological innovation in pharmaceutical engineering of Chinese medicine unveils a vision on "Future Factory" of Chinese medicine industry in mind. The strategy as well as the technical roadmap of "Chinese medicine industry 4.0" is proposed, with the projection of related core technology system. It is clarified that the technical development path of Chinese medicine industry from digital manufacture to intelligent manufacture. On the basis of precisely defining technical terms such as process control, on-line detection and process quality monitoring for Chinese medicine manufacture, the technical concepts and characteristics of intelligent pharmaceutical manufacture as well as digital pharmaceutical manufacture are elaborated. Promoting wide applications of digital manufacturing technology of Chinese medicine is strongly recommended. Through completely informationized manufacturing processes and multi-discipline cluster innovation, intelligent manufacturing technology of Chinese medicine should be developed, which would provide a new driving force for Chinese medicine industry in technology upgrade, product quality enhancement and efficiency improvement. Copyright© by the Chinese Pharmaceutical Association.

New imaging systems in nuclear medicine. Technical progress report, October 1, 1976--May 31, 1977

International Nuclear Information System (INIS)

Brownell, G.L.

1977-01-01

Work carried out on the development of instrumentation and techniques for positron scintigraphy is discussed. Progress in positron imaging instrumentation and applications is detailed. The assembly and initial evaluation of the new multicrystal positron camera, PC-II, has been completed. Images have been obtained in both two and three-dimensions which demonstrate the basic physical properties of the instrument. Successful measurements using transverse section imaging have been carried out on animals and human volunteers. Physiological investigation using PC-II is proceeding. A flexible and accurate computer program has been developed for transverse section reconstruction of data acquired by PC-II. This program makes it possible to reconstruct both the activity distribution and the distribution of absorption. The program has been developed in such a way that it can handle variations in the data collection procedure. Clinical studies using PC-I and PC-II are being carried on in areas of heart, lung and brain

Seminar Pediatrics. Medical and Technical Applications

International Nuclear Information System (INIS)

Montivero, M.; Nespral, D.O.; Alak, Maria del Carmen

2012-01-01

The Association of Biology and Nuclear Medicine has organized the 'Seminar Pediatrics - Medical and Technical Applications', held in Buenos Aires in May 2012, in order to collaborate with the scientific growth of nuclear medicine in pediatrics. The main topics covered were: management of pediatric patients and medical application in childhood, dosimetry in pediatric nuclear medicine, scope of radioisotope - studies in nephrourological pathologies, PET in pediatrics, among others.

What is legal medicine--are legal and forensic medicine the same?

Science.gov (United States)

Beran, Roy G

2010-04-01

Some consider the terms "forensic" and "legal" medicine to be synonymous but this is counter to the title of the Faculty of Forensic and Legal Medicine or the dual strands for progression to fellowship of the Australian College of Legal Medicine. The paper examines a very brief historical background to legal medicine and develops a definition of the strands thereof, namely legal and forensic medicine. It demonstrates that the two are different components of the application of medical knowledge upon the legal system. Legal medicine has greater relevance to civil and tort law, impacting upon patient care, whereas forensic medicine relates to criminal law and damage to, or by, patients.

The progress of Chinese burn medicine from the Third Military Medical University-in memory of its pioneer, Professor Li Ao.

Science.gov (United States)

Li, Haisheng; Zhou, Junyi; Peng, Yizhi; Zhang, Jiaping; Peng, Xi; Luo, Qizhi; Yuan, Zhiqiang; Yan, Hong; Peng, Daizhi; He, Weifeng; Wang, Fengjun; Liang, Guangping; Huang, Yuesheng; Wu, Jun; Luo, Gaoxing

2017-01-01

Professor Li Ao was one of the founders of Chinese burn medicine and one of the most renowned doctors and researchers of burns in China. He established one of the Chinese earliest special departments for burns at Third Military Medical University (TMMU) in 1958. To memorialize Professor Li Ao on his 100th birthday in 2017 and introduce our extensive experience, it is our honor to briefly review the development and achievement of the Chinese burn medicine from TMMU. The epidemiology and outcomes of admitted burn patients since 1958 were reviewed. Furthermore, main achievements of basic and clinical research for the past roughly 60 years were presented. These achievements mainly included the Chinese Rule of Nine, fluid resuscitation protocol, experience in inhalation injury, wound treatment strategies, prevention and treatment of burn infections, nutrition therapy, organ support therapies, and rehabilitation. The progress shaped and enriched modern Chinese burn medicine and promoted the development of world burn medicine.

INFLUENCE OF AEROSPACE MEDICINE ACHIEVEMENTS ON THE DEVELOPMENT OF SPORT MEDICINE METHODOLOGY.

Science.gov (United States)

R Yashina, E R; Kurashvili, V A; Turzin, P S

Modern technologies of aerospace medicine develop at rapid pace pulling on its orbit all spheres of the human activity, including sport. Innovations play a major role in the progress of sport medicine areas related to the biomedical support of precontest training. Overview of the most important aerospace medicine achievements and their methodical implications for sport medicine is presented. Discussion is devoted to how the aerospace medicine technologies can raise effectiveness of the biomedical support to different sectors of sport and fitness.

Solar lease grant program. Technical progress report

Energy Technology Data Exchange (ETDEWEB)

1981-04-01

Progress on a lease program for the installation of a solar water heater with no installation charge is reported. Information on the announcement of the program, the selection of participants, the contractural agreement, progress on installation of equipment, monitoring, and evaluation is summarized. The status of the budget concerned with the program is announced. Forms used for applications for the program and an announcement from Resource Alternatives for Cilco customers are presented.

Integrative Medicine in Preventive Medicine Education

Science.gov (United States)

Jani, Asim A.; Trask, Jennifer; Ali, Ather

2016-01-01

During 2012, the USDHHS’s Health Resources and Services Administration funded 12 accredited preventive medicine residencies to incorporate an evidence-based integrative medicine curriculum into their training programs. It also funded a national coordinating center at the American College of Preventive Medicine, known as the Integrative Medicine in Preventive Medicine Education (IMPriME) Center, to provide technical assistance to the 12 grantees. To help with this task, the IMPriME Center established a multidisciplinary steering committee, versed in integrative medicine, whose primary aim was to develop integrative medicine core competencies for incorporation into preventive medicine graduate medical education training. The competency development process was informed by central integrative medicine definitions and principles, preventive medicine’s dual role in clinical and population-based prevention, and the burgeoning evidence base of integrative medicine. The steering committee considered an interdisciplinary integrative medicine contextual framework guided by several themes related to workforce development and population health. A list of nine competencies, mapped to the six general domains of competence approved by the Accreditation Council of Graduate Medical Education, was operationalized through an iterative exercise with the 12 grantees in a process that included mapping each site’s competency and curriculum products to the core competencies. The competencies, along with central curricular components informed by grantees’ work presented elsewhere in this supplement, are outlined as a roadmap for residency programs aiming to incorporate integrative medicine content into their curricula. This set of competencies adds to the larger efforts of the IMPriME initiative to facilitate and enhance further curriculum development and implementation by not only the current grantees but other stakeholders in graduate medical education around integrative medicine

Antimicrobial resistance and the guidelines of the International Cooperation on Harmonisation of Technical Requirements for Registration of Veterinary Medicinal Products (VICH).

Science.gov (United States)

Marion, H

2012-04-01

The International Cooperation on Harmonisation of Technical Requirements for Registration of Veterinary Medicinal Products (VICH) is an international tripartite cooperation programme that brings together regulatory authorities and industry representatives from the European Union, Japan and the United States, with Australia, New Zealand and Canada as observers. VICH aims to improve international coordination and cooperation to achieve greater harmonisation of the requirements for veterinary product registration in the regions concerned. VICH develops harmonised data requirements, i.e., standards for the scientific studies on quality, safety and efficacy that are required to obtain a marketing authorisation for a veterinary medicinal product. It does this by publishing guidelines that provide uniform and consistent guidance for sponsors to follow in developing data for application dossiers as well as for post-marketing safety monitoring of veterinary medicinal products. Of the 49 VICH guidelines that have been developed so far, two guidelines in particular address issues related to antimicrobial resistance.

The story of technical cooperation

International Nuclear Information System (INIS)

Park, Yang Taek

1989-09-01

This book gives descriptions of technical cooperation, which is about why does technology transfer?, process of technology transfer with model, decisive cause and cooperation of technology transfer, cost and effect of technology transfer, historical experience of technology transfer, cases of technology transfer by field such as rubber tire, medicine and computer industry and automobile industry, technology transfer process and present condition of technical cooperation, and strategy for rising of technical cooperation : selection of technology for object of cooperation and development of human resources.

Management of Radioactive Spills in Nuclear Medicine; Teaching and Assessing with Objectively Structured Assessment of Technical Skills

International Nuclear Information System (INIS)

Hussain, Riffat Parveen

2015-01-01

Routine work in nuclear medicine requires the careful elution of radioactivity and its subsequent, storage and handling. Though all effort is maintained to prevent any “spill” of this radioactivity, accidents are bound to happen. The response to this spill is a methodically worked out a plan that is written and adopted as a “standard operating procedure.” This protocol is taught to all involved in the area of working as a mock drill/apprenticeship model. No formal evaluation of learning is in place except for the mock drills. The objectively structured assessment of technical skills (OSATS) is a variation on the Objective Structured Clinical Examination, which is a form of workplace based assessment. The OSATS is cited in the Accreditation Council of Graduate Medical Education evaluation toolbox on the website as the most desirable evaluation tool for the patient care topics. It is the objective of this paper is to introduce the “OSATS” for teaching, and assessment of the learning, of the protocol for the management of radioactive spill. As a review of the literature on the subject failed to reveal any such teaching protocol/material/document for this important technical skill, we hope that it may act as a landmark for the development of teaching and assessment of other technical skills also

Technical progress report

International Nuclear Information System (INIS)

1996-01-01

This report summarizes experimental and theoretical work in basic nuclear physics carried out between October 1, 1995, the closing of our last Progress Report, and September 30, 1996 at the Nuclear Physics Laboratory of the University of Colorado, Boulder, under contracts DE-FG03-93ER-40774 and DE-FG03-95ER-40913 with the United States Department of Energy. The experimental contract supports broadly-based experimental research in intermediate energy nuclear physics. This report includes results from studies of Elementary Systems involving the study of the structure of the nucleon via polarized high-energy positron scattering (the HERMES experiment) and lower energy pion scattering from both polarized and unpolarized nucleon targets. Results from pion- and kaon-induced reactions in a variety of nuclear systems are reported under the section heading Meson Reactions; the impact of these and other results on understanding the nucleus is presented in the Nuclear Structure section. In addition, new results from scattering of high-energy electrons (from CEBAF/TJNAF) and pions (from KEK) from a broad range of nuclei are reported in the section on Incoherent Reactions. Finally, the development and performance of detectors produced by the laboratory are described in the section titled Instrumentation

A systematic assessment of the state of hazardous waste clean-up technologies. Quarterly technical progress report, April 1--June 30, 1993

Energy Technology Data Exchange (ETDEWEB)

Berg, M.T.; Reed, B.E.; Gabr, M.

1993-07-01

West Virginia University (WVU) and the US DOE Morgantown Energy Technology Center (METC) entered into a Cooperative Agreement on August 29, 1992 entitled ``Decontamination Systems Information and Research Programs.`` Stipulated within the Agreement is the requirement that WVU submit to METC a series of Technical Progress Report for Year 1 of the Agreement. This report reflects the progress and/or efforts performed on the following nine technical projects encompassed by the Year 1 Agreement for the period of April 1 through June 30, 1993: Systematic assessment of the state of hazardous waste clean-up technologies; site remediation technologies -- drain-enhanced soil flushing (DESF) for organic contaminants removal; site remediation technologies -- in situ bioremediation of organic contaminants; excavation systems for hazardous waste sites; chemical destruction of polychlorinated biphenyls; development of organic sensors -- monolayer and multilayer self-assembled films for chemical sensors; Winfield lock and dam remediation; Assessments of Technologies for hazardous waste site remediation -- non-treatment technologies and pilot scale test facility implementation; and remediation of hazardous sites with stream reforming.

A concise guide to nuclear medicine

CERN Document Server

Elgazzar, Abdelhamid H

2011-01-01

Nuclear medicine is an important component of modern medicine. This easy-to-use book is designed to acquaint readers with the basic principles of nuclear medicine, the instrumentation used, the gamut of procedures available, and the basis for selecting specific diagnostic or therapeutic procedures and interpreting results. After an introductory chapter on the history, technical basis, and scope of nuclear medicine, a series of chapters are devoted to the application of nuclear medicine techniques in the different body systems. In addition, the use of nuclear medicine methods within oncology is

[Research progress on potential liver toxic components in traditional Chinese medicine].

Science.gov (United States)

Wu, Hao; Zhong, Rong-Ling; Xia, Zhi; Huang, Hou-Cai; Zhong, Qing-Xiang; Feng, Liang; Song, Jie; Jia, Xiao-Bin

2016-09-01

In recent years, the proportion of traditional Chinese medicine in scientific research and its clinical use increased gradually. The research result also becomes more and more valuable, but in the process of using traditional Chinese medicine, it also needs to pay more attention. With the gradual deepening of the toxicity of traditional Chinese medicine, some traditional Chinese medicines have also been found to have the potential toxicity, with the exception of some traditional toxicity Chinese medicine. Traditional Chinese medicine in the growth, processing, processing, transportation and other aspects of pollution or deterioration will also cause the side effects to the body. Clinical practice should be based on the theory of traditional Chinese medicine to guide rational drug use and follow the symptomatic medication, the principle of proper compatibility. The constitution of the patients are different, except for a few varieties of traditional Chinese medicines are natural herbs with hepatotoxicity, liver toxicity of most of the traditional Chinese medicine has idiosyncratic features. The liver plays an important role in drug metabolism. It is easy to be damaged by drugs. Therefore, the study of traditional Chinese medicine potential liver toxicity and its toxic components has become one of the basic areas of traditional Chinese medicine research. Based on the review of the literatures, this paper summarizes the clinical classification of liver toxicity, the pathogenesis of target cell injury, and systematically summarizes the mechanism of liver toxicity and toxic mechanism of traditional Chinese medicine. This paper provided ideas for the study of potential liver toxicity of traditional Chinese medicine and protection for clinical safety of traditional Chinese medicine. Copyright© by the Chinese Pharmaceutical Association.

76 FR 57054 - International Cooperation on Harmonisation of Technical Requirements for Registration of...

Science.gov (United States)

2011-09-15

...] International Cooperation on Harmonisation of Technical Requirements for Registration of Veterinary Medicinal... (MRK),'' (VICH GL46). This guidance has been developed for veterinary use by the International Cooperation on Harmonisation of Technical Requirements for Registration of Veterinary Medicinal Products (VICH...

Report of activities of the radiation medicine sector - 1983

International Nuclear Information System (INIS)

1984-01-01

The radiation medicine programs, participation in work groups, bibliography about radiation medicine, systematic register of nuclear accidents, technical-scientifical interexchange, participation in congress, seminaries and others events, elaboration of technical-scientifical works, bibliographical consults, participation in palestras of Prevention Weeks of Work Accidents, training in hygiene of ionizing radiations and so on, are the topics presented. (M.A.C.) [pt

GT-MHR COMMERCIALZATION STUDY. TECHNICAL PROGRESS AND COST MANAGEMENT REPORT FOR THE PERIOD MAY 1 THROUGH MAY 31, 2003

International Nuclear Information System (INIS)

SHENOY, A.S.

2003-01-01

A271 GT-MHR COMMERCIALZATION STUDY TECHNICAL PROGRESS AND COST MANAGEMENT REPORT FOR THE PERIOD MAY 1 THROUGH MAY 31, 2003. Petten advised GA the start of the HFR-EU2 irradiation is being delayed until late July 2004. HFR-EU1 (pebble fuel) is also delayed until February/March 2004. The reason for the delays was implementation of new financial regulations at Petten that delayed the contracts for capsule fabrication. Review of the MHR-2 Fuel Product Specification was completed. Revision of the specification to incorporate the review results is in progress. Detailed test matrices have been drafted for capsule irradiation tests and for post-irradiation heating tests proposed for development and qualification of advanced coated-particle fuels capable of meeting anticipated VHTR fuel performance requirements

Index to Nuclear Safety. A technical progress review by chronology, permuted title, and author. Vol 11, No. 1 through Vol. 16, No. 6

International Nuclear Information System (INIS)

Cottrell, W.B.; Klein, A.

1976-04-01

This index to Nuclear Safety covers articles in Nuclear Safety Vol. 11, No. 1 (Jan.-Feb. 1970) through Vol. 16, No. 6 (Nov.-Dec. 1975). Included in the index is a chronological list of articles (including abstract) followed by both a KWIC index and an Author Index. Nuclear Safety is a bimonthly technical progress review prepared by the Nuclear Safety Information Center and covers all safety aspects of nuclear power reactors and associated facilities. The index lists over 300 technical articles in the last six years of publication

Index to Nuclear Safety. A technical progress review by chronology, permuted title, and author. Vol 11, No. 1 through Vol. 16, No. 6

Energy Technology Data Exchange (ETDEWEB)

Cottrell, W.B.; Klein, A.

1976-04-01

This index to Nuclear Safety covers articles in Nuclear Safety Vol. 11, No. 1 (Jan.-Feb. 1970) through Vol. 16, No. 6 (Nov.-Dec. 1975). Included in the index is a chronological list of articles (including abstract) followed by both a KWIC index and an Author Index. Nuclear Safety is a bimonthly technical progress review prepared by the Nuclear Safety Information Center and covers all safety aspects of nuclear power reactors and associated facilities. The index lists over 300 technical articles in the last six years of publication.

Urology technical and non-technical skills development: the emerging role of simulation.

Science.gov (United States)

Rashid, Prem; Gianduzzo, Troy R J

2016-04-01

To review the emerging role of technical and non-technical simulation in urological education and training. A review was conducted to examine the current role of simulation in urology training. A PUBMED search of the terms 'urology training', 'urology simulation' and 'urology education' revealed 11,504 titles. Three hundred and fifty-seven abstracts were identified as English language, peer reviewed papers pertaining to the role of simulation in urology and related topics. Key papers were used to explore themes. Some cross-referenced papers were also included. There is an ongoing need to ensure that training time is efficiently utilised while ensuring that optimal technical and non-technical skills are achieved. Changing working conditions and the need to minimise patient harm by inadvertent errors must be taken into account. Simulation models for specific technical aspects have been the mainstay of graduated step-wise low and high fidelity training. Whole scenario environments as well as non-technical aspects can be slowly incorporated into the curriculum. Doing so should also help define what have been challenging competencies to teach and evaluate. Dedicated time, resources and trainer up-skilling are important. Concurrent studies are needed to help evaluate the effectiveness of introducing step-wise simulation for technical and non-technical competencies. Simulation based learning remains the best avenue of progressing surgical education. Technical and non-technical simulation could be used in the selection process. There are good economic, logistic and safety reasons to pursue the process of ongoing development of simulation co-curricula. While the role of simulation is assured, its progress will depend on a structured program that takes advantage of what can be delivered via this medium. Overall, simulation can be developed further for urological training programs to encompass technical and non-technical skill development at all stages, including

Power systems development facility. Quarterly technical progress report, January 1, 1994--March 31, 1994

Energy Technology Data Exchange (ETDEWEB)

1994-07-01

This quarterly technical progress report summarizes work completed during the last quarter of the Second Budget Period, January 1 through March 31, 1994, entitled {open_quotes}Hot Gas Cleanup Test Facility for Gasification and Pressurized Combustion.{close_quotes} The objective of this project is to evaluate hot gas particulate control technologies using coal-derived gas streams. This will entail the design, construction, installation, and use of a flexible test facility which can operate under realistic gasification and combustion conditions. The major particulate control device issues to be addressed include the integration of the particulate control devices into coal utilization systems, on-line cleaning techniques, chemical and thermal degradation of components, fatigue or structural failures, blinding, collection efficiency as a function of particle size, and scale-up of particulate control systems to commercial size.

[Application progress of proteomic in pharmacological study of Chinese medicinal formulae].

Science.gov (United States)

Liu, Yu-Qian; Zhan, Shu-Yu; Ruan, Yu-Er; Zuo, Zhi-Yan; Ji, Xiao-Ming; Wang, Shuai-Jie; Ding, Bao-Yue

2017-10-01

Chinese medicinal formulae are the important means of clinical treatment in traditional Chinese medicine. It is urgent to use modern advanced scientific and technological means to reveal the complicated mechanism of Chinese medicinal formulae because they have the function characteristics of multiple components, multiple targets and integrated regulation. The systematic and comprehensive research model of proteomic is in line with the function characteristics of Chinese medicinal formulae, and proteomic has been widely used in the study of pharmacological mechanism of Chinese medicinal formulae. The recent applications of proteomic in pharmacological study of Chinese medicinal formulae in anti-cardiovascular and cerebrovascular diseases, anti-liver disease, antidiabetic, anticancer, anti-rheumatoid arthritis and other diseases were reviewed in this paper, and then the future development direction of proteomic in pharmacological study of Chinese medicinal formulae was put forward. This review is to provide the ideas and method for proteomic research on function mechanism of Chinese medicinal formulae. Copyright© by the Chinese Pharmaceutical Association.

Analysis of External Treatment Methods and Technical Characteristics of External Treatment

Science.gov (United States)

Zhang, Rui; Miao, Mingsan; Bai, Ming

2018-01-01

Chinese medicine external therapy is a treatment method of Chinese medicine with Chinese characteristics. The effect of traditional Chinese medicine external treatment, convenient operation, external treatment and technology has great prospects for development. The traditional Chinese medicine external treatment method and technical characteristics were analyzed.

48 CFR 742.1170-4 - Progress reporting requirements and contract clause.

Science.gov (United States)

2010-10-01

... progress. (b) Because the cognizant technical officer is the individual most familiar with the contractor's performance, the contractor must submit the progress reports directly to the cognizant technical officer. The cognizant technical officer must review the reports and advise the contracting officer, in writing, of any...

Medicinal Plants in Neurodegenerative Diseases: Perspective of Traditional Persian Medicine.

Science.gov (United States)

Farzaei, Mohammad Hosein; Shahpiri, Zahra; Mehri, Mohammad Reza; Bahramsoltani, Roodabeh; Rezaei, Mahdi; Raeesdana, Azade; Rahimi, Roja

2018-01-01

Neurodegenerative diseases are a progressive loss of structure and/or function of neurons. Weak therapeutic response and progressive nature of the diseases, as well as a wide range of side effects caused by conventional therapeutic approaches make patients seek for complementary and alternative medicine. The aim of the present paper is to discuss the neuropharmacological basis of medicinal plants and their principle phytochemicals which have been used in traditional Persian medicine for different types of neurodegenerative diseases. Medicinal plants introduced in traditional Persian medicine perform beneficial effects in neurodegenerative diseases via various cellular and molecular mechanisms including suppression of apoptosis mediated by an increase in the expression of anti-apoptotic agents (e.g. Bcl-2) as well as a decrease in the expression and activity of proapoptotic proteins (e.g. Bax, caspase 3 and 9). Alleviating inflammatory responses and suppressing the expression and function of pro-inflammatory cytokines like Tumor necrosis factor α and interleukins, as well as improvement in antioxidative performance mediated by superoxide dismutase and catalase, are among other neuroprotective mechanisms of traditional medicinal plants. Modulation of transcription, transduction, intracellular signaling pathways including ERK, p38, and MAPK, with upstream regulatory activity on inflammatory cascades, apoptosis and oxidative stress associated pathways, play an essential role in the preventive and therapeutic potential of the plants in neurodegenerative diseases. Medicinal plants used in traditional Persian medicine along with their related phytochemicals by affecting various neuropharmacological pathways can be considered as future drugs or adjuvant therapies with conventional pharmacotherapeutics; though, further clinical studies are necessary for the confirmation of their safety and efficacy. Copyright© Bentham Science Publishers; For any queries, please email at

Progress on RNAi-based molecular medicines

OpenAIRE

Chen, Jing; Xie, Jianping

2012-01-01

Jing Chen, Jianping XieInstitute of Modern Biopharmaceuticals, State Key Laboratory Breeding Base of Ministry of Education Eco-Environment of the Three Gorges Reservoir Region, School of Life Sciences, Southwest University, Chongqing, ChinaAbstract: RNA interference (RNAi) is a promising strategy to suppress the expression of disease-relevant genes and induce post-transcriptional gene silencing. Their simplicity and stability endow RNAi with great advantages in molecular medicine. Several RNA...

Nuclear structure theory. Annual technical progress report, July 1, 1975--September 30, 1976

International Nuclear Information System (INIS)

French, J.B.; Koltun, D.S.

1976-01-01

This report summarizes progress during the past year in the following areas of nuclear structure and reaction theory: Meson interactions with nucleons and nuclei, including elastic and inelastic scattering of pions, three-body theories of scattering and absorption of pions by deuterons, π-p bremsstrahlung, and multiple-excitation models for meson absorption by heavier nuclei. Studies of the inverse scattering problem including 1 S 0 nucleon-nucleon scattering; the relativistic two-body problem, particularly for relativistic effects at low energies: the unitary-pole expansion in nucleon-nucleon scattering with hard-core interactions. Statistical spectroscopy including: strength distributions and sum rules(both energy weighted and inverse energy weighted) for nuclear excitations; fluctuations and correlations in spectra, strengths and expectation values; studies of Garvey-Kelson and similar mass relationships; spectroscopy in huge spaces including spectral methods for renormalization of the interaction and for using (two + three)-body Skyrme interactions; technical aspects of operator averaging

New imaging systems in nuclear medicine. Technical progress report

International Nuclear Information System (INIS)

Brownell, G.L.

1986-01-01

We continue to improve the operation of PCR-I, a single ring demonstration ststem employing analog coding to achieve high resolution (4 to 5 mm), high sensitivity (45,000 c/s/ Ci/cc) and high sampling frequency without interpolative motion. This device is designed for brain imaging in humans and for animal studies. An intensive program of software development was carried out concurrently with hardware development and led to the PL/S computer system used for PCI and PCII. Subsequently, more powerful systems were developed using a Data General Eclipse computer and, more recently, an IBM PC/AT computer with array processor. This experience gives us confidence that we can develop a computer system capable of handling the data processes and display requirements of PCR-II. 1 fig., 1 tab

Nuclear medicine and imaging research. Quantitative studies in radiopharmaceutical science. Comprehensive progress report, January 1, 1983-June 30, 1985

International Nuclear Information System (INIS)

Beck, R.N.; Cooper, M.D.

1985-09-01

This comprehensive report outlines the progress made during the past three years in the areas described below. In all instances, initial studies have been carried out and the technical feasibility of carrying through each study has been demonstrated. The studies described include development of cesium-130 and bromine-75 radioisotope generators, the feasibility of using rubidium-82 as a myocardial imaging agent, and radiochemical preparation of C-11 deoxyglucose. 28 refs. (DT)

Emergency medicine resident crisis resource management ability: a simulation-based longitudinal study

Directory of Open Access Journals (Sweden)

Samuel Clarke

2014-12-01

Full Text Available Background: Simulation has been identified as a means of assessing resident physicians’ mastery of technical skills, but there is a lack of evidence for its utility in longitudinal assessments of residents’ non-technical clinical abilities. We evaluated the growth of crisis resource management (CRM skills in the simulation setting using a validated tool, the Ottawa Crisis Resource Management Global Rating Scale (Ottawa GRS. We hypothesized that the Ottawa GRS would reflect progressive growth of CRM ability throughout residency. Methods: Forty-five emergency medicine residents were tracked with annual simulation assessments between 2006 and 2011. We used mixed-methods repeated-measures regression analyses to evaluate elements of the Ottawa GRS by level of training to predict performance growth throughout a 3-year residency. Results: Ottawa GRS scores increased over time, and the domains of leadership, problem solving, and resource utilization, in particular, were predictive of overall performance. There was a significant gain in all Ottawa GRS components between postgraduate years 1 and 2, but no significant difference in GRS performance between years 2 and 3. Conclusions: In summary, CRM skills are progressive abilities, and simulation is a useful modality for tracking their development. Modification of this tool may be needed to assess advanced learners’ gains in performance.

Precision medicine and traditional chinese medicine of dialogue

Directory of Open Access Journals (Sweden)

Lou Xin

2017-01-01

Full Text Available The precision medicine is more precise individualized medicine, based on the patient’s genes or physiological to formulate the specific treatment plan, for the realization of individualized treatment of various diseases to provide valuable information.But with the progress of modern science and technology, modern medicine dependence on medical instruments are too serious, traditional ways are gradually forgotten.If the machine depends on the instrument test results too serious which don’t combined with the actual diagnosis, the cause of misdiagnosis, so we should pay attention to the overall analysis of diseases and systematic diagnosis and examination, use of the overall treatment concept traced back to find the cause of Traditional Chinese Medicine, finally decide to select a best treatment plan.We should use the dialectical attitude to look at the precise medical. Not blindly requirements according to the road of precision medicine of Traditional Chinese Medicine to go, to shine in himself field, form of self characteristic of Traditional Chinese Medicine.Can learn some of the advantages of accurate concept, the good and rejecting the bad, hope the Traditional Chinese Medicine in the modern environment more walk more far.

A pluralist challenge to "integrative medicine": Feyerabend and Popper on the cognitive value of alternative medicine.

Science.gov (United States)

Kidd, Ian James

2013-09-01

This paper is a critique of 'integrative medicine' as an ideal of medical progress on the grounds that it fails to realise the cognitive value of alternative medicine. After a brief account of the cognitive value of alternative medicine, I outline the form of 'integrative medicine' defended by the late Stephen Straus, former director of the US National Centre for Complementary and Alternative Medicine. Straus' account is then considered in the light of Zuzana Parusnikova's recent criticism of 'integrative medicine' and her distinction between 'cognitive' and 'opportunistic' engagement with alternative medicine. Parusnikova warns that the medical establishment is guilty of 'dogmatism' and proposes that one can usefully invoke Karl Popper's 'critical rationalism' as an antidote. Using the example of Straus, I argue that an appeal to Popper is insufficient, on the grounds that 'integrative medicine' can class as a form of cognitively-productive, critical engagement. I suggest that Parusnikova's appeal to Popper should be augmented with Paul Feyerabend's emphasis upon the role of 'radical alternatives' in maximising criticism. 'Integrative medicine' fails to maximise criticism because it 'translates' alternative medicine into the theories and terminology of allopathic medicine and so erodes its capacity to provide cognitively-valuable 'radical alternatives'. These claims are then illustrated with a discussion of 'traditional' and 'medical' acupuncture. I conclude that 'integrative medicine' fails to exploit the cognitive value of alternative medicine and so should be rejected as an ideal of medical progress. Copyright © 2013 Elsevier Ltd. All rights reserved.

Nuclear waste glass melter: an update of technical progress

International Nuclear Information System (INIS)

Brouns, R.A.; Hanson, M.S.

1984-08-01

The direct slurry-fed ceramic-lined melter is currently the reference US process for treating defense and civilian high-level liquid waste. Extensive nonradioactive pilot-scale testing at Pacific Northwest Laboratory (PNL) and Savannah River Laboratory has proven the process, defined operating parameters, and identified successful equipment design concepts. Programs at PNL continue to support several of the planned US vitrification plants through preparation of equipment designs and flowsheet testing. Current emphasis is on remotization of equipment, radioactive verification testing, and resolution of remaining technical issues. Development of this technology, technical status, and planned development activities are discussed. 9 references, 4 figures

Tomography in nuclear medicine

International Nuclear Information System (INIS)

Levi de Cabrejas, Mariana

1999-01-01

This book is a contribution to the training and diffusion of the tomography method image diagnosis in nuclear medicine, which principal purpose is the information to professionals and technical personnel, specially for the spanish speaking staff

48 CFR 2052.211-70 - Preparation of technical reports.

Science.gov (United States)

2010-10-01

....211-70 Preparation of technical reports. As prescribed at 2011.104-70(a), the contracting officer... Reports (JAN 1993) All technical reports required by Section C and all Technical Progress Reports required... 48 Federal Acquisition Regulations System 6 2010-10-01 2010-10-01 true Preparation of technical...

Evolutionary molecular medicine.

Science.gov (United States)

Nesse, Randolph M; Ganten, Detlev; Gregory, T Ryan; Omenn, Gilbert S

2012-05-01

Evolution has long provided a foundation for population genetics, but some major advances in evolutionary biology from the twentieth century that provide foundations for evolutionary medicine are only now being applied in molecular medicine. They include the need for both proximate and evolutionary explanations, kin selection, evolutionary models for cooperation, competition between alleles, co-evolution, and new strategies for tracing phylogenies and identifying signals of selection. Recent advances in genomics are transforming evolutionary biology in ways that create even more opportunities for progress at its interfaces with genetics, medicine, and public health. This article reviews 15 evolutionary principles and their applications in molecular medicine in hopes that readers will use them and related principles to speed the development of evolutionary molecular medicine.

FY13 Annual Progress Report for SECA Core Technology Program

Energy Technology Data Exchange (ETDEWEB)

Stevenson, Jeffry W. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Koeppel, Brian J. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States)

2014-01-31

This progress report covers technical work performed during fiscal year 2013 at PNNL under Field Work Proposal (FWP) 40552. The report highlights and documents technical progress in tasks related to advanced cell and stack component materials development and computational design and simulation.

The challenge of the future. Technical progress and ecological perspectives

International Nuclear Information System (INIS)

Jischa, M.F.

1993-01-01

The book introduces readers into the interrelated global problems population dynamics, energy supply, imminent climate catastrophe, environmetal pollution, finite resources and the conflict between the North and South. It encourages probing more deeply into the technical challenges of the future. The author demonstrates why economic and technical issues will soon be outstripped by questions of the environmental, human and social compatibility of new technologies. (orig./UA) [de

Regional cooperation to stimulate technical progress

International Nuclear Information System (INIS)

Ridvan, M.; Ehjrej, P.L.

1987-01-01

The main principles of the IAEA regional agreement on co-operation in the field of researches, elaboration and training of specialists in nuclear science and engineering for the states of Asia and Pacific Ocean region (RAC) and of the ARCAL program in Latin America are considered. The RAC projects envisage co-operation in the field of medicine (radiotherapy and nuclear methods, sterilization, etc.), agriculture (nuclear methods, raising of plants, using radiation mutations, food irradiation, etc.), industry (application of isotopes and radiation technology) and others. The ARCAL projects comprise radiation protection, nuclear control instruments, nuclear analytic methods, radioimmune analysis in stock-breeding, product irradiation, nuclear information, etc

The Progress of Emergency Medicine in Taiwan, China, and Hong Kong: Perspective from Publications in Emergency Medicine Journals, 1992–2011

Directory of Open Access Journals (Sweden)

Ching-Hsing Lee

2014-01-01

Full Text Available Study Objective. The progress of emergency medicine (EM in Taiwan, China, and Hong Kong was evaluated from the perspective of publications in EM journals. Methods. This was a retrospective study. All articles published from 1992 to 2011 in all journals in the EM category in the 2010 Journal Citation Reports (JCR were included. A computerized literature search was conducted using the SciVerse Scopus database. The slope (β of the linear regression was used to evaluate the trends in the numbers of articles as well as the ratios to the total number of EM journal articles. Results. The trends in the numbers of articles from Taiwan, China, and Hong Kong were 6.170, 1.908, and 2.835 and the trends in the ratios of their publication numbers to the total number of EM journal articles were 15.0 × 10−4, 4.60 × 10−4, and 6.80 × 10−4, respectively. All P-values were <0.01. The mean, median, and 75th percentiles of the number of citations in all EM journals were greater than those of these three areas. Conclusions. The publications from Taiwan, China, and Hong Kong have increased at a higher rate than those of the overall EM field in the past 20 years and indicated the rapid progress in these three areas.

[Research progress in phytoestrogens of traditional Chinese medicine].

Science.gov (United States)

Zhao, Yuan; Zheng, Hong-Xia; Xu, Ying; Lin, Na

2017-09-01

Phytoestrogens are plant-derived compounds, which have a similarity in structure with human endogenous estrogen 17-β-estradiol. Structural likeness enables phytoestrogens to interact with estrogen receptors, not simply mimicking the effects of human steroidal estrogen but also exhibiting similar and divergent actions. The global literature relating to phytoestrogen in recent years was systematically summarized in this paper. Chemical compositions of phytoestrogens were mainly flavonoids, coumarins, lignans, terpenoids, steroids, etc., with a character of prevention and treatment of perimenopausal syndrome, osteoporosis, cardiovascular disease, metabolic diseases, cancer, regulation of brain function and other pharmacological effects. The mechanisms of action mainly included classical estrogen receptor pathway, epigenetic effect, activation of 5'-adenosyl-phospho-activated protein kinase, inhibition of kinase, activation of peroxisome proliferator-activated receptor, regulation of apoptosis-related proteins, inhibition of nuclear factor κB signaling pathway and so on. According to their efficacy classification, phytoestrogens were mainly distributed in the tonifying medicines, blood-activating and stasis-resolving medicines and heat-clearing medicines. The classical prescriptions with estrogen activity included tonifying formula, Qi-regulating formula and harmonizing formula, etc. This review was aimed at providing a certain reference for the further study of phytoestrogens by researchers and clinicians. Copyright© by the Chinese Pharmaceutical Association.

What Is Trust? Ethics and Risk Governance in Precision Medicine and Predictive Analytics.

Science.gov (United States)

Adjekum, Afua; Ienca, Marcello; Vayena, Effy

2017-12-01

Trust is a ubiquitous term used in emerging technology (e.g., Big Data, precision medicine), innovation policy, and governance literatures in particular. But what exactly is trust? Even though trust is considered a critical requirement for the successful deployment of precision medicine initiatives, nonetheless, there is a need for further conceptualization with regard to what qualifies as trust, and what factors might establish and sustain trust in precision medicine, predictive analytics, and large-scale biology. These new fields of 21st century medicine and health often deal with the "futures" and hence, trust gains a temporal and ever-present quality for both the present and the futures anticipated by new technologies and predictive analytics. We address these conceptual gaps that have important practical implications in the way we govern risk and unknowns associated with emerging technologies in biology, medicine, and health broadly. We provide an in-depth conceptual analysis and an operative definition of trust dynamics in precision medicine. In addition, we identify three main types of "trust facilitators": (1) technical, (2) ethical, and (3) institutional. This three-dimensional framework on trust is necessary to building and maintaining trust in 21st century knowledge-based innovations that governments and publics invest for progressive societal change, development, and sustainable prosperity. Importantly, we analyze, identify, and deliberate on the dimensions of precision medicine and large-scale biology that have carved out trust as a pertinent tool to its success. Moving forward, we propose a "points to consider" on how best to enhance trust in precision medicine and predictive analytics.

Periodic progress report, 6 months

DEFF Research Database (Denmark)

Juhl, Thomas Winther; Nielsen, Jakob Skov

This is the first progress report of the BriteEuram project named "High Power Laser Cutting for Heavy Industry" ("Powercut"). The report contains a summary of the objectives of the first period, an overview of the technical progress, a comparison between the planed and the accomplished work...

Decomposing productivity growth allowing efficiency gains and price-induced technical progress

NARCIS (Netherlands)

Oude Lansink, A.G.J.M.; Silva, E.; Stefanou, S.

2000-01-01

Time- and firm-specific output technical efficiency measures are generated within a price-induced technological change framework. The firm-specific production frontier incorporates past prices as an argument encouraging innovation and a time trend to account for exogenous technical change. The

[Progress of sulfur fumigation and modern processing technology of Chinese traditional medicines].

Science.gov (United States)

Lu, Tu-Lin; Shan, Xin; Li, Lin; Mao, Chun-Qin; Ji, De; Yin, Fang-Zhou; Lang, Yong-Ying

2014-08-01

Infestation, moldy and other phenomenon in the processing and storage of Chinese herbal medicines is a problem that faced in the production of Chinese traditional medicine. The low productivity of traditional processing methods can not guarantee the quality of Chinese herbal medicines. Sulfur fumigation is the first choice of grassroots to process the Chinese herbal medicine with its low cost and easy operation. Sulfur fumigation can solve some problems in the processing and storage of Chinese herbal medicines, but modern pharmacological studies show that long-term use of Chinese traditional medicine which is fumigated by sulfur can cause some serious harm to human liver, kidney and other organs. This paper conducts a review about the application history of sulfur fumigation, its influence to the quality of Chinese herbal medicines as well as domestic and foreign limits to sulfur quantity, and a brief introduction of the status of modern processing technologies in the processing of food and some Chinese herbal medicines, the problems ex- isting in the Chinese herbal medicines processing, which can provide a reference basis for the further research, development and application of investigating alternative technologies of sulfur fumigation.

PFBC HGCU Test Facility. Technical progress report No. 24, Third quarter, CY 1995

Energy Technology Data Exchange (ETDEWEB)

NONE

1995-10-01

This is the twenty-fourth and final Technical Progress Report submitted to the Department of Energy (DOE) in connection with the cooperative agreement between the DOE and Ohio Power Company for the Tidd PFBC Hot Gas Clean Up Test Facility. This report covers the work completed during the Third Quarter of CY 1995. All activity this quarter was directed toward the completion of the program final report. A draft copy of the final report was forwarded to DOE during this quarter, and DOE submitted their comments on the report to AEPSC. DOE requested that Westinghouse write an appendix to the report covering the performance of the fail-safe regenerator devices during Tad operation, and Westinghouse subsequently prepared the appendix. Additional DOE comments were incorporated into the report, and it will be issued in camera-ready form by the end of October, 1995, which is the program end date. Appendix 1 presents the results of filter candle posttest examination by Westinghouse performed on selected filter candles following final shutdown of the system.

Installations of in-vivo nuclear medicine: Minimal technical rules of design, operation and maintenance. Guide Nr 32 - Release of the 2017/05/24

International Nuclear Information System (INIS)

2017-01-01

After having evoked the regulatory context, this document details the different articles contained by a decision taken by the ASN in October 2014 to define the minimal technical rules of design, operation and maintenance of installations dedicated to in-vivo nuclear medicine. It is therefore written for the different professions involved in nuclear medicine, and its content is to be reflected by modifications introduced in the French labour code and public health code. The following issues and aspects are addressed: general principles adopted for the decision, design rules (for premises, for equipments and for premises ventilation), operation rules (general and specific rules), and various and transient measures. For each of these issues, the texts of concerned articles are indicated and their content is then explained in a detailed way

The progress of pediatric nuclear medicine

International Nuclear Information System (INIS)

Ishii, Katsumi

1979-01-01

Radioisotopes rarely used for children because of the risk of radiation. However, recently radioisotopes have been used extensively for children to make the early diagnosis of many disorders, such as Meckel's diverticum, tumors, infantile hepatitis, congenital common bileduct atresias, since the development of the radioisotopes with short half life, sup(99m)TcO 4 - or the similar substances labelled with sup(99m)Tc. There are few problems physically and technically dealing with the indication of radioisotopes for children. The radioisotopes with short half life therefore, seems to be used more commonly for children in the future. (author)

Potentials for progress in laser medicine

International Nuclear Information System (INIS)

Parrish, J.A.; Walsh, J.T. Jr.

1985-01-01

Lasers could come to occupy a highly important position in the armament of medicine. They are the brightest known sources of light, man-made or natural, and emit light having such properties as coherence and monochromaticity. Furthermore, lasers have the ability to deliver very brief pulses of light which can cause unique alterations in biological materials. The major obstacle to the increased use of lasers in medicine and surgery is not the availability of laser devices, but the dearth of basic information about laser-tissue interactions. We have recently demonstrated that, even in turbid tissue such as the dermis, it is possible simultaneously to induce microscopically selective thermal damage, localized to millions of selectively absorbing targets, while sparing surrounding tissues. These targets may be as small as organelles or as large as blood vessels. Such localized thermal damage is truly unique to pulsed laser exposures. The scope and medical utility of these lesions has yet to be fully understood. Thus, there is much research to be done in describing and characterizing laser-induced injury. There is, however, ample evidence that several laser therapies could be improved by using selectively absorbed, short pulses that lead to the spatial confinement of thermal injury. Treatment of port wine stains, pigmented lesions, atheromatous arterial plaques, and the fragmentation of kidney and gall stones are examples. It should also be possible to use a variety of systems to deliver exogenous laser targets on or within individual types of cells or organelles. Such chromophores may lead to new forms of cancer therapy, for example

Efficacy of clinical diagnostic procedures utilized in nuclear medicine. Technical progress report, 1 December 1981-30 November 1982

International Nuclear Information System (INIS)

Saenger, E.L.

1982-07-01

The efficacy of nuclear medicine diagnostic procedures was measured. Three levels of efficacy were defined. However, two different methods of evaluating efficacy itself were first compared. Using two methods, logistic regression and entropy-minimax pattern detection, substantial agreement was found between them in several clinical observations. (1) There are no attributes that indicate that any grouping of symptoms, signs, and laboratory findings is capable of suggesting that a patient does or does not have a pulmonary embolus. (2) The lung scan test is the only reliable method which indicates that a patient may have a pulmonary embolus or does not have a pulmonary embolus. (3) The validity of these conclusions and the ability to apply them widely to ongoing clinical practice is based on the prospective design of the Study which included an appropriate distribution of institutions by type, size, and geographic location. Also, the only judgement samples was that of the referring physician

[Application of digital earth technology in research of traditional Chinese medicine resources].

Science.gov (United States)

Liu, Jinxin; Liu, Xinxin; Gao, Lu; Wei, Yingqin; Meng, Fanyun; Wang, Yongyan

2011-02-01

This paper describes the digital earth technology and its core technology-"3S" integration technology. The advance and promotion of the "3S" technology provide more favorable means and technical support for Chinese medicine resources survey, evaluation and appropriate zoning. Grid is a mature and popular technology that can connect all kinds of information resources. The author sums up the application of digital earth technology in the research of traditional Chinese medicine resources in recent years, and proposes the new method and technical route of investigation in traditional Chinese medicine resources, traditional Chinese medicine zoning and suitability assessment by combining the digital earth technology and grid.

[Research progress on current pharmacokinetic evaluation of Chinese herbal medicines].

Science.gov (United States)

Li, Guofu; Zhao, Haoru; Yang, Jin

2011-03-01

In order to prove safety and efficacy, herbal medicines must undergo the rigorous scientific researches such as pharmacokinetic and bioavailability, before they are put on the market in the foreign countries. Botanical Drug Products promulgated by the US FDA could guide industry sponsors to develop herbal drugs, which was also an important reference for investigating Chinese herbal medicines. This paper reviews and discusses novel approaches for how to assess systemic exposure and pharmacokinetic of Chinese herbal medicines, which were in line with FDA guidance. This mainly focus on identifying pharmacokinetic markers of botanical products, integral pharmacokinetic study of multiple components, Biopharmaceutics drug disposition classification system, and population pharmacokinetic-pharmacodynamic study in herb-drug interaction.

[Research progress on standardization study of NIR spectroscopy based method for quality control of traditional Chinese medicine].

Science.gov (United States)

Li, Wen-Long; Qu, Hai-Bin

2016-10-01

In recent years, the near infrared (NIR) spectroscopy has gained wide acceptance within the quantitative analysis of traditional Chinese medicine (TCM). However, the lack of technical standards is the bottleneck problem in this process. To address this issue, standardization study of the NIR spectroscopy based method for the quantitative analysis of TCM is needed, in which the specific characteristics of TCM should be given full considerations. The main research contents include:the scope definition for the application of NIR spectroscopy in the TCM quantitative analysis field, the selection criteria for the sample pretreatment and spectral acquisition conditions, the rules for the model optimization and evaluation, and the regulations for the model update and transfer. In this paper, some foreign studies in the agricultural areas are reviewed for reference. Different chemometrics methods reported in the literature are investigated and compared systematically. This research is important actual significance to the theoretical development of NIR spectroscopy analytical techniques, and will effectively promote the application of the technology in the TCM industry. Furthermore, it is beneficial to improve the technical level of TCM quality control, and can also be used as references to achieve similar purposes for other natural products. Copyright© by the Chinese Pharmaceutical Association.

Appropriability, Technological Opportunity, Market Demand, and Technical Change - Empirical Evidence from Switzerland

OpenAIRE

Harabi, Najib

1992-01-01

The purpose of this paper is to analyze both theoretically and empirically those factors which underlay the - empirically observable - inter-industry differences in technical progress. At the theoretical level economists agree more and more that technical progress can be explained at the industry level by the following three factors: (1) the technological opportunities, (2) the appropriability conditions, meaning the ability to capture and protect the results of technical innovations and (3) ...

[Advanced organ failure in the elderly. Some issues from a geriatrics, palliative medicine and bioethics perspectives].

Science.gov (United States)

Alonso-Renedo, Francisco Javier; González-Ercilla, Leire; Iráizoz-Apezteguía, Itziar

2014-01-01

To analyze the literature as regards the knowledge, skills and attitudes that these disciplines can provide in improving technical, ethical and human quality health care in the elderly with advanced organ failure, multimorbidity, frailty and progressive dementia. A comprehensive review focused on available references on the interrelationship between geriatric medicine and palliative medicine, education in bioethics, prognostic tools, functional status, and the humanization of health care. Advance care planning, comprehensive geriatric assessment, the study of the values of the patient and their introduction in decision-making process, as well as the need to promote moral, care, and healthcare organizational ethics, are essential elements to achieve this objective. Practitioners and healthcare organizations should seek excellence as a moral requirement. To achieve this, there is a priority to acquire virtues of care and fundamental concepts of geriatric and palliative medicine, assessing functional status, advance care planning and patient/family needs as essential issues to protect, care for and promote them in all care settings. Copyright © 2013 SEGG. Published by Elsevier Espana. All rights reserved.

High temperature turbine technology program. Phase II. Technology test and support studies. Annual technical progress report, January 1, 1979-December 31, 1979

Energy Technology Data Exchange (ETDEWEB)

1980-01-01

Work performed on the High Temperature Turbine Technology Program, Phase II - Technology Test and Support Studies during the period from January 1, 1979 through December 31, 1979 is summarized. Objectives of the program elements as well as technical progress and problems encountered during this Phase II annual reporting period are presented. Progress on design, fabrication and checkout of test facilities and test rigs is described. LP turbine cascade tests were concluded. 350 hours of testing were conducted on the LP rig engine first with clean distillate fuel and then with fly ash particulates injected into the hot gas stream. Design and fabrication of the turbine spool technology rig components are described. TSTR 60/sup 0/ sector combustor rig fabrication and testing are reviewed. Progress in the design and fabrication of TSTR cascade rig components for operation on both distillate fuel and low Btu gas is described. The new coal-derived gaseous fuel synthesizing facility is reviewed. Results and future plans for the supporting metallurgical programs are discussed.

GPHS-RTGs in support of the Cassini mission. Semi annual technical progress report, 2 October 1995--31 March 1996

International Nuclear Information System (INIS)

1996-01-01

The technical progress achieved during the period 2 October 1995 through 31 March 1996 on Contract No. DE-AC03-91SF18852, Radioisotope Generators and Ancillary Activities is described herein. This report is organized by the program task structure as follows: spacecraft integration and liaison; engineering support; safety; qualified unicouple fabrication; ETG fabrication, assembly, and test; ground support equipment (GSE); RTG shipping and launch support; designs, reviews, and mission applications; project management, quality assurance and reliability, contract changes, non-capital CAGO acquisition, and CAGO maintenance; contract acquired government-owned property (CAGO) acquisition; and program calendars

Regulatory problems in nuclear medicine

International Nuclear Information System (INIS)

Vandergrift, J.F.

1987-01-01

Governmental involvement in the practice of medicine has increased sharply within the past few years. The impact on health care has, for the most part, been in terms of financial interactions between health care facilities and federally funded health services programs. One might say that this type of governmental involvement has indirect impact on the medical and/or technical decisions in the practice of nuclear medicine. In other areas, however, governmental policies and regulations have had a more direct and fundamental impact on nuclear medicine than on any other medical specialty. Without an understanding and acceptance of this situation, the practice of nuclear medicine can be very frustrating. This chapter is thus written in the hope that potential frustration can be reduced or eliminated

ISABELLE: a progress report

Energy Technology Data Exchange (ETDEWEB)

Hahn, H

1980-01-01

This paper discusses the ISABELLE project, which has the objective of constructing a high-energy proton colliding beam facility at Brookhaven National Laboratory. The major technical features of the intersecting storage accelerators with their projected performance are described. Application of over 1000 superconducting magnets in the two rings represents the salient characteristic of the machine. The status of the entire project, the technical progress made so far, and difficulties encountered are reviewed.

ISABELLE: a progress report

International Nuclear Information System (INIS)

Hahn, H.

1980-01-01

This paper discusses the ISABELLE project, which has the objective of constructing a high-energy proton colliding beam facility at Brookhaven National Laboratory. The major technical features of the intersecting storage accelerators with their projected performance are described. Application of over 1000 superconducting magnets in the two rings represents the salient characteristic of the machine. The status of the entire project, the technical progress made so far, and difficulties encountered are reviewed

The general technical regulation and the standardization

International Nuclear Information System (INIS)

Laverie, Michel; Houze, Christian; Lebouleux, Philippe

1980-01-01

Through a certain number of procedures, the thorough appreciation of the safety of a nuclear installation relies more on a specific appreciation taking into account the references as a whole, than on a technical regulation which claims to cover all the problems. Nevertheless, a French technical regulation structure regarding the safety domain must be built up progressively. The authors consider the principles of such a structure, and together they make the inventory of the works, finished, in progress or contemplated. The description of this specifically French approach emphazises the multiple and complementary forms given to statutory implements [fr

Innovations in travel medicine and the progress of tourism-Selected narratives

DEFF Research Database (Denmark)

Hjalager, Anne Mette

2009-01-01

Health and tourism is an emerging theme in research. Focus of this article is on travel medicine, which is a well-established discipline in the medical sciences, but not yet quite so in the social sciences. There is a limited insight into the relationship between innovations and developments...... in medicines on the one hand, and economics and institutionalisation of tourism on the other hand. The article explores this issue. Three narratives provide examples of the interconnections. The first case describes developments in drugs for malaria and relations with tourism. The second case addresses...... recreational drugs. The third case investigates the concept of wilderness medicine and the pharmaceuticals and medical gears that facilitate this category of tourism. Thus, the paper demonstrates through some examples that innovations in the medical fields and institutionalisation of the use of medicine may...

Non-technical constraints to eradication: the Italian experience.

Science.gov (United States)

Moda, Giuliana

2006-02-25

Although technical constraints to eradication of bovine tuberculosis are well-recognised, non-technical constraints can also delay progress towards eradication, leading to inefficiency and increased programme costs. This paper seeks to analyse the main non-technical constraints that can interfere with the successful implementation of tuberculosis eradication plans, based on experiences from an area of high tuberculosis prevalence in Regione Piemonte, Italy. The main social and economic constraints faced in the past 20 years are reviewed, including a social reluctance to recognise the importance of seeking eradication as the goal of disease control, effective communication of technical issues, the training and the organization of veterinary services, the relationship between the regional authority and farmers and their representatives, and data management and epidemiological reporting. The paper analyses and discusses the solutions that were applied in Regione Piemonte and the benefits that were obtained. Tuberculosis eradication plans are one of the most difficult tasks of the Veterinary Animal Health Services, and non-technical constraints must be considered when progress towards eradication is less than expected. Organizational and managerial resources can help to overcome social or economic obstacles, provided the veterinary profession is willing to address technical, but also non-technical, constraints to eradication.

Progress in scaffold-free bioprinting for cardiovascular medicine.

Science.gov (United States)

Moldovan, Nicanor I

2018-06-01

Biofabrication of tissue analogues is aspiring to become a disruptive technology capable to solve standing biomedical problems, from generation of improved tissue models for drug testing to alleviation of the shortage of organs for transplantation. Arguably, the most powerful tool of this revolution is bioprinting, understood as the assembling of cells with biomaterials in three-dimensional structures. It is less appreciated, however, that bioprinting is not a uniform methodology, but comprises a variety of approaches. These can be broadly classified in two categories, based on the use or not of supporting biomaterials (known as "scaffolds," usually printable hydrogels also called "bioinks"). Importantly, several limitations of scaffold-dependent bioprinting can be avoided by the "scaffold-free" methods. In this overview, we comparatively present these approaches and highlight the rapidly evolving scaffold-free bioprinting, as applied to cardiovascular tissue engineering. © 2018 The Author. Journal of Cellular and Molecular Medicine published by John Wiley & Sons Ltd and Foundation for Cellular and Molecular Medicine.

TECHNICAL COORDINATION

CERN Multimedia

A. Ball and W. Zeuner

2011-01-01

In this report we will review the main achievements of the Technical Stop and the progress of several centrally-managed projects to support CMS operation and maintenance and prepare the way for upgrades. Overview of the extended Technical Stop  The principal objectives of the extended Technical Stop affecting the detector itself were the installation of the TOTEM T1 telescopes on both ends, the readjustment of the alignment link-disk in YE-2, the replacement of the light-guide sleeves for all PMs of both HFs, and some repairs on TOTEM T2 and CASTOR. The most significant tasks were, however, concentrated on the supporting infrastructure. A detailed line-by-line leak search was performed in the C6F14 cooling system of the Tracker, followed by the installation of variable-frequency drives on the pump motors of the SS1 and SS2 tracker cooling plants to reduce pressure transients during start-up. In the electrical system, larger harmonic filters were installed in ...

Effects of humic substances on the migration of radionuclides: complexation and transport of actinides. First technical progress report (work period 01.97 - 12.97)

International Nuclear Information System (INIS)

Buckau, G.

1998-08-01

The present report describes progress within the first year of the EC-project 'Effects of Humic Substances on the Migration of Radionuclides: Complexation and Transport of Actinides'. The project is conducted within the EC-Cluster 'Radionuclide Transport/Retardation Processes'. Contrary to formal requirements of the Commission, this report with a great deal of detail is established already after one year of project work. It is scheduled to be followed by a second technical progress report covering the second year of the project. In agreement with the contractual obligations a final report of similar technical detail will also be generated. The report contains an executive summary written by the coordinator (FZK/INE) with strong support from the other three task leaders (BGS, CEA-SGC and RMC-E). More detailed results are given by individual contributions of the project partners in 13 annexes. In the executive summary report the origin of results presented is given, also serving as guidance for finding more detailed results in the annexes. Not all results are discussed or referred to in the executive summary report and thus readers with a deeper interest also need to consult the annexes. (orig.)

Progress report 1981

International Nuclear Information System (INIS)

Chalupka, A.; Dirninger, G.

1982-01-01

The progress report describes the scientific work and research results of the institute for radium research and nuclear physics of the Austrian Academy of Sciences for the period of 1981. The progress report covers the subject areas of nuclear theory, nuclear model calculations, experimental nuclear physics and neutron involved reactions, medium energy physics, instrumentation and detectors, evaluation of nuclear data and numerical data processing, dating, applications in medicine, dosimetry and environmental studies. A list of publications of this institute is given. (A.N.)

Progress report 1982

International Nuclear Information System (INIS)

Chalupka, A.; Wild, E.; Dirninger, G.

1983-01-01

The progress report describes the scientific work and research results of the institute for radium research and nuclear physics of the Austrian Academy of Sciences for the period of 1982. The progress report covers the subject areas of nuclear theory, nuclear model calculations, experimental nuclear physics and neutron involved reactions, medium energy physics, instrumentation and detectors, evaluation of nuclear data and numerical data processing, dating, applications in medicine, dosimetry and environmental studies. A list of publications of this institute is given. (A.N.)

[Location information acquisition and sharing application design in national census of Chinese medicine resources].

Science.gov (United States)

Zhang, Xiao-Bo; Li, Meng; Wang, Hui; Guo, Lan-Ping; Huang, Lu-Qi

2017-11-01

In literature, there are many information on the distribution of Chinese herbal medicine. Limited by the technical methods, the origin of Chinese herbal medicine or distribution of information in ancient literature were described roughly. It is one of the main objectives of the national census of Chinese medicine resources, which is the background information of the types and distribution of Chinese medicine resources in the region. According to the national Chinese medicine resource census technical specifications and pilot work experience, census team with "3S" technology, computer network technology, digital camera technology and other modern technology methods, can effectively collect the location information of traditional Chinese medicine resources. Detailed and specific location information, such as regional differences in resource endowment and similarity, biological characteristics and spatial distribution, the Chinese medicine resource census data access to the accuracy and objectivity evaluation work, provide technical support and data support. With the support of spatial information technology, based on location information, statistical summary and sharing of multi-source census data can be realized. The integration of traditional Chinese medicine resources and related basic data can be a spatial integration, aggregation and management of massive data, which can help for the scientific rules data mining of traditional Chinese medicine resources from the overall level and fully reveal its scientific connotation. Copyright© by the Chinese Pharmaceutical Association.

Designing HIGH-COST medicine: hospital surveys, health planning, and the paradox of progressive reform.

Science.gov (United States)

Perkins, Barbara Bridgman

2010-02-01

Inspired by social medicine, some progressive US health reforms have paradoxically reinforced a business model of high-cost medical delivery that does not match social needs. In analyzing the financial status of their areas' hospitals, for example, city-wide hospital surveys of the 1910s through 1930s sought to direct capital investments and, in so doing, control competition and markets. The 2 national health planning programs that ran from the mid-1960s to the mid-1980s continued similar strategies of economic organization and management, as did the so-called market reforms that followed. Consequently, these reforms promoted large, extremely specialized, capital-intensive institutions and systems at the expense of less complex (and less costly) primary and chronic care. The current capital crisis may expose the lack of sustainability of such a model and open up new ideas and new ways to build health care designed to meet people's health needs.

Some aspects of the development of nuclear medicine in the USSR

International Nuclear Information System (INIS)

Kasatkin, Yu.N.

1989-01-01

Principle directions of the development of nuclear medicine in the USSR are presented.Some problems, which solution affects the state of nuclear medicine in the country are discussed. Problems of technical equipment of nuclear-diagnostic investigations are considered. Measures, directed to improvement of proffesional traing of specialists dealing with nuclear medicine are planned

Technical and economical analysis of costs of diagnostic agents in 'in vivo' nuclear medicine. proposition of fixing of a price scale

International Nuclear Information System (INIS)

Karcher, G.; Prigent, A.; Pelletier, J.L.; Gremillet, E.; Fallais, Ch.

2005-03-01

By basing us on indisputable scientific references for the good practices of nuclear medicine (recommendations of learned and international societies for the most part of acts), on precise technical analysis for certain difficult points (generators of 99 mTc, factors of calibration,multi doses flasks ), on an inquiry of frequency of acts concerning about 300 000 acts in 43 services in 2003, and on price lists of 2005 of the products available on the French market (which almost totality were analyzed by the commission of transparency of the A.F.S.S.a.P.S. during the granting of the approval in aid of communities), we were able to calculate the unit costs of radiopharmaceuticals used for each of the acts of the C.C.A.M. recovering from the nuclear medicine, that is a hundred of values. By grouping together these values according to a rigorous methodology, we built 12 groups of heterogeneousness limited in ±15 Euros for the weakest values and ±15 % for the others, and which constitute a useful tariff base in daily practice. (N.C.)

The research progress of nuclear medicine on cardiovascular molecular imaging

International Nuclear Information System (INIS)

Yin Xiaohua; Zhang Yongxue

2007-01-01

Cardiovascular molecular imaging is a rapidly evolving discipline and its clinical application is promising. Nuclear medicine is playing a leading role in this field with its special superiority of noninvasive, quantifiability, high sensitivity and specificity. It provides broad opportunities for exploring the pathophysiologic process of cardiovascular diseases and monitoring its gene therapy in the molecular level. In this review, we mainly discuss some basic knowledge on cardiovascular molecular imaging, and then focus on the applied research prospect of nuclear medicine radionuclide imaging. (authors)

A Retrospective Analysis of Precision Medicine Outcomes in Patients With Advanced Cancer Reveals Improved Progression-Free Survival Without Increased Health Care Costs.

Science.gov (United States)

Haslem, Derrick S; Van Norman, S Burke; Fulde, Gail; Knighton, Andrew J; Belnap, Tom; Butler, Allison M; Rhagunath, Sharanya; Newman, David; Gilbert, Heather; Tudor, Brian P; Lin, Karen; Stone, Gary R; Loughmiller, David L; Mishra, Pravin J; Srivastava, Rajendu; Ford, James M; Nadauld, Lincoln D

2017-02-01

The advent of genomic diagnostic technologies such as next-generation sequencing has recently enabled the use of genomic information to guide targeted treatment in patients with cancer, an approach known as precision medicine. However, clinical outcomes, including survival and the cost of health care associated with precision cancer medicine, have been challenging to measure and remain largely unreported. We conducted a matched cohort study of 72 patients with metastatic cancer of diverse subtypes in the setting of a large, integrated health care delivery system. We analyzed the outcomes of 36 patients who received genomic testing and targeted therapy (precision cancer medicine) between July 1, 2013, and January 31, 2015, compared with 36 historical control patients who received standard chemotherapy (n = 29) or best supportive care (n = 7). The average progression-free survival was 22.9 weeks for the precision medicine group and 12.0 weeks for the control group ( P = .002) with a hazard ratio of 0.47 (95% CI, 0.29 to 0.75) when matching on age, sex, histologic diagnosis, and previous lines of treatment. In a subset analysis of patients who received all care within the Intermountain Healthcare system (n = 44), per patient charges per week were $4,665 in the precision treatment group and $5,000 in the control group ( P = .126). These findings suggest that precision cancer medicine may improve survival for patients with refractory cancer without increasing health care costs. Although the results of this study warrant further validation, this precision medicine approach may be a viable option for patients with advanced cancer.

Recent progress in medical imaging technology

International Nuclear Information System (INIS)

Endo, Masahiro

2004-01-01

Medical imaging is name of methods for diagnosis and therapy, which make visible with physical media such as X-ray, structures and functions of man's inside those are usually invisible. These methods are classified by the physical media into ultrasound imaging, magnetic resonance imaging, nuclear medicine imaging and X-ray imaging etc. Having characteristics different from one another, these are used complementarily in medical fields though in some case being competitive. Medical imaging is supported by highly progressed technology, which is called medical imaging technology. This paper describes a survey of recent progress of medical imaging technology in magnetic resonance imaging, nuclear medicine imaging and X-ray imaging. (author)

Personalized medicine in dentistry

Directory of Open Access Journals (Sweden)

Pushpa S Pudakalkatti

2017-01-01

Full Text Available Personalized medicine is a branch of medicine that proposes customization of healthcare in which decisions and treatment are tailored according to individual patient needs. The field of personalized medicine relies on genetic information, proteomic information and clinical patient characteristics to individualize treatment. With advances in genetics, proteomics, pharmacogenetics and knowledgeable patient population, the opportunity exists to deliver never before levels of personalized care. Although general dentists may consider personalized medicine a concept for the future, the reality is that its direct application to everyday dentistry is closer than one might think. Use of personalized medicine in dentistry, especially in periodontology is progressing rapidly, and dentist should consider this approach while treating patients. Google and PubMed search was done to select articles for present review. Total 17 articles were used to compile information.

Cardiovascular nuclear medicine and MRI

International Nuclear Information System (INIS)

Reiber, J.H.C.; Wall, E.E. van der

1992-01-01

This book is based on a meeting of the Working Group on Nuclear Cardiology, which held March 22-23,1991 under the auspices of the European Society of Cardiology and the Interuniversity Cardiology Institute of the Netherlands, and on the Second International Symposium on Computer Applications in Nuclear Medicine and Cardiac Magnetic Resonance Imaging, which was held March 20-22,1991 in Rotterdam, the Netherlands. It covers almost every aspect of quantitative cardio-vascular nuclear medicine and magnetic resonance imaging. The main topics are: single photon emission computed tomography (technical aspects); new development in cardiovascular nuclear medicine; advances in cardiovascular imaging; cardiovascular clinical applications; and cardiac magnetic resonance imaging. (A.S.). refs.; figs.; tabs

COMPETENCE IN MEDICINE

Directory of Open Access Journals (Sweden)

Hélio Teixeira MD.

2005-01-01

Full Text Available Medical competence is the result of a lifelong evolving process, based on the development of efficiency, experience and ethical principles. Efficiency in medical practice depends on scientific knowledge, technical abilities and communication skills. Experience is a process of personal refinement, breeding knowledge and wisdom. Finally, medical ethics is founded on the quest for justice, compassion and love. Didactically, we can distinguish three phases in the professional evolution of a physician: a Professional infancy, or linear vision: the physician restricts his attention to the morbid process only, often neglecting the patient in his totality. His approach is almost exclusively technical, with limited perception of medicine as an art. b Professional maturity or humanistic vision: it results from the evolution of personality, culture and experience of the physician, who foccuses now on the patient as a whole with his disease(s. c Professional excellence, or holistic vision, the highest stage: when the physician's integrated dimensions and wisdom are projected into the patient, fostering the natural conditions for optimal healing. We conclude that the practice of medicine is best fulfilled when both, art and cience, are considered and exercised together by the doctor.

Progress report for '89

International Nuclear Information System (INIS)

Podest, M.

1990-08-01

The 1989 Progress Report presents the most important scientific and technical achievements of the Nuclear Research Institute's research work. Some specialized products prepared at or fabricated by the NRI are mentioned as well. (author). 24 figs., 8 tabs., 101 refs

Precision medicine for nurses: 101.

Science.gov (United States)

Lemoine, Colleen

2014-05-01

To introduce the key concepts and terms associated with precision medicine and support understanding of future developments in the field by providing an overview and history of precision medicine, related ethical considerations, and nursing implications. Current nursing, medical and basic science literature. Rapid progress in understanding the oncogenic drivers associated with cancer is leading to a shift toward precision medicine, where treatment is based on targeting specific genetic and epigenetic alterations associated with a particular cancer. Nurses will need to embrace the paradigm shift to precision medicine, expend the effort necessary to learn the essential terminology, concepts and principles, and work collaboratively with physician colleagues to best position our patients to maximize the potential that precision medicine can offer. Copyright © 2014 Elsevier Inc. All rights reserved.

C-Mod Collaboration Informal Technical Progress Report

International Nuclear Information System (INIS)

Kenneth W. Gentle

2007-01-01

The aims of the collaboration have not changed. A specific list of tasks was agreed upon during the Fall of 2006 in preparation for the 2007 C-Mod campaign by Earl Marmar, Head of the Alcator Project, Kenneth Gentle, Principal Investigator, and William Rowan, Collaboration Coordinator with the facilitation of Adam Rosenberg (DOE grant monitor for the collaboration). The activities follow the list of tasks and are discussed in this progress report

Essentials of nuclear medicine physics and instrumentation

CERN Document Server

Powsner, Rachel A; Powsner, Edward R

2013-01-01

An excellent introduction to the basic concepts of nuclear medicine physics This Third Edition of Essentials of Nuclear Medicine Physics and Instrumentation expands the finely developed illustrated review and introductory guide to nuclear medicine physics and instrumentation. Along with simple, progressive, highly illustrated topics, the authors present nuclear medicine-related physics and engineering concepts clearly and concisely. Included in the text are introductory chapters on relevant atomic structure, methods of radionuclide production, and the interaction of radiation with matter. Fu

Progress report 1979

International Nuclear Information System (INIS)

1980-12-01

This progress report deals with technical and research work done at the AAEC Research Establishment in the twelve month period ending September 30, 1979. Work done in the following research divisions is reported: Applied Maths and Computing, Chemical Technology, Engineering Research, Environmental Science, Instrumentation and Control, Isotope, Materials and Physics

76 FR 57060 - International Cooperation on Harmonisation of Technical Requirements for Registration of...

Science.gov (United States)

2011-09-15

...] International Cooperation on Harmonisation of Technical Requirements for Registration of Veterinary Medicinal... veterinary use by the International Cooperation on Harmonisation of Technical Requirements for Registration... regulatory authorities and industry associations to promote the international harmonization of regulatory...

77 FR 20406 - International Cooperation on Harmonisation of Technical Requirements for Registration of...

Science.gov (United States)

2012-04-04

...] International Cooperation on Harmonisation of Technical Requirements for Registration of Veterinary Medicinal... been developed for veterinary use by the International Cooperation on Harmonisation of Technical... industry associations to promote the international harmonization of regulatory requirements. FDA has...

78 FR 14308 - International Cooperation on Harmonisation of Technical Requirements for Registration of...

Science.gov (United States)

2013-03-05

...] International Cooperation on Harmonisation of Technical Requirements for Registration of Veterinary Medicinal... been developed for veterinary use by the International Cooperation on Harmonisation of Technical... regulatory authorities and industry associations to promote the international harmonization of regulatory...

Progress ill Small-Bowel Physiology and Disease

African Journals Online (AJOL)

1971-10-23

Oct 23, 1971 ... Gastro-intestinal Clinic and Department of Medicine, Groote Schuur Hospital and University of Cape Town ... Many of these advances have been due to technical skills in physiology, biochemistry and radiology, but newer.

PACS in nuclear medicine

International Nuclear Information System (INIS)

Kang, Keon Wook

2000-01-01

PACS (Picture Archiving and Communication System) is being rapidly spread and installed in many hospitals, but most of the system do not include nuclear medicine field. Although additional costs of hardware for nuclear medicine PACS is low, the complexity in developing viewing software and little market have made the nuclear medicine PACS not popular. Most PACS utilize DICOM 3.0 as standard format, but standard format in nuclear medicine has been Interfile. Interfile should be converted into DICOM format if nuclear images are to be stored and visualized in most PACS. Nowadays, many vendors supply the DICOM option in gamma camera and PET. Several hospitals in Korea have already installed nucler PACS with DICOM, but only the screen captured images are supplied. Software for visualizing pseudo-color with color lookup tables and expressing with volume view should be developed to fulfill the demand of referring physicians and nuclear medicine physicians. PACS is going to integrate not only radiologic images but also endoscopic and pathologic images. Web and PC based PACS is now a trend and is much compatible with nuclear medicine PACS. Most important barrier for nuclear medicine PACS that we encounter is not a technical problem, but indifference of investor such as administrator of hospital or PACS. Now it is time to support and invest for the development of nuclear medicine PACS

Progress report [of] Technical Physics Division

International Nuclear Information System (INIS)

Vijendran, P.; Deshpande, R.Y.

1975-01-01

Activities of the Technical Physics Division of the Bhabha Atomic Research Centre, Bombay, over the last few years are reported. This division is engaged in developing various technologies supporting the development of nuclear technology. The various fields in which development is actively being carried out are : (i) vacuum technology, (ii) mass spectrometry, (iii) crystal technology, (iv) cryogenics, and (v) magnet technology. For surface studies, the field emission microscope and the Auger electron spectrometer and other types of spectrometers have been devised and perfected. Electromagnets of requisite strength to be used in MHD programme and NMR instruments are being fabricated. Various crystals such as NaI(Tl), Ge, Fluorides, etc. required as windows and prisms in X and gamma-ray spectroscopy, have been grown. In the cryogenics field, expansion engines required for air liquefaction plants, vacuum insulated dewars, helium gas thermometers etc. have been constructed. In addition to the above, the Division provides consultancy and training to personnel from various institutions and laboratories. Equipment and systems perfected are transferred to commercial organizations for regular production. (A.K.)

Stem cells: progressions and applications in clinical medicine

Directory of Open Access Journals (Sweden)

Ali Hosseini Bereshneh

2016-05-01

Full Text Available Stem cells are undifferentiated and multi pluripotent cells which can differentiate into a variety of mature cells and tissues such as nervous tissue, muscle tissue, epithelial tissue, skeletal tissue and etc. Stem cells from all different source have three unique features: 1 Proliferative capability: Stem cells are capable of self dividing and self renewing for long periods or more than six months at least that called immortalization. 2 Undifferentiated nature: It’s considered as one of the essential characteristics of stem cell, so it doesn't have any tissue-specific construction. 3 Differentiation to the different cells from all organs: This ability can Induced by tissue specific transcription factors. Because of that, they are so important in prevention and treatment of human disease. Depending on the sources from which they derive, they have different types which can be used to produce special cells and tissues. The most significant types of stem cells are; embryonic stem cells (ESCs which are derived from embryos, adult stem cells (ASCs which are derived from differentiated cells in a specific tissue, induced pluripotent stem cells (iPSs which are produced from adult differentiated cells that have been genetically reprogrammed to act resemble to an embryonic stem cell and cord blood stem cells which contains haematopoietic stem cells and derived from the umbilical cord after gestation. By providing a medium containing of special growth factor, it is possible to orientated stem cell differentiation pathway and gained certain cells from them. The important uses of stem cells includes damaged heart tissue cells improvements and bone tissue repairing, cancer treatment, damaged neurological and spinal tissue repairing, improving burns and injuries and the treatment of diabetes, infertility and spermatogenesis dysfunction. Furthermore, the application of them in gene therapy is an important issue in the modern medicine science due to the role

The development of an e-learning software, ''Technical ethics''

International Nuclear Information System (INIS)

Matsue, Kazuki; Madarame, Haruki; Okamoto, Koji

2004-01-01

For the engineers and researchers, it is coming to the time when they are asked not only technical progress but also their ethics view. In this study, I aim to develop of the education software ''Technical Ethics'', which cultivates ethics view of the engineers. (author)

Defining user requirements for tele-nuclear medicine applications: from technical feasibility to clinical results

International Nuclear Information System (INIS)

Todd-Pokropek, A.; Chanachai, R.

2002-01-01

Purpose: Defining the user requirements for tele-nuclear medicine systems, in particular in developing countries, is an important prerequisite to establishing a service. However, the availability of low cost PC based servers and, now, access to local ISPs, has made the technical provision of such networks relatively simple and low cost, although transfer of data to and form legacy systems still present many difficulties. Method and Materials: The key driving force in developing countries is the imbalance between skills in the relatively few centres of excellence and the increasing number of installations overall. Requirements include both very rapid remote reporting and/or overnight tele-consultation. Original raw NM data must be available not just 'images'. Using current network standards (VPN) data transfer rate requirements are low. Provision of image fusion between NM, CT and MRI is also highly desirable. Results: Experience has been obtained e.g. in Thailand and Morocco, where a network of servers and remote users, with cardiac application of particular importance, has demonstrated benefit, and increasing volumes of usage. Conclusions: However, the requirements need to be clearly defined, and a staff training program is essential, as is a full evaluation. The transfer of skills is important in raising the overall quality of health care

75 FR 18505 - International Cooperation on Harmonisation of Technical Requirements for Registration of...

Science.gov (United States)

2010-04-12

...] International Cooperation on Harmonisation of Technical Requirements for Registration of Veterinary Medicinal... veterinary use by the International Cooperation on Harmonisation of Technical Requirements for Registration... promote the international harmonization of regulatory requirements. FDA has participated in efforts to...

76 FR 57057 - International Cooperation on Harmonisation of Technical Requirements for Registration of...

Science.gov (United States)

2011-09-15

...] International Cooperation on Harmonisation of Technical Requirements for Registration of Veterinary Medicinal... veterinary use by the International Cooperation on Harmonisation of Technical Requirements for Registration... undertaken by regulatory authorities and industry associations to promote the international harmonization of...

76 FR 57058 - International Cooperation on Harmonisation of Technical Requirements for Registration of...

Science.gov (United States)

2011-09-15

...] International Cooperation on Harmonisation of Technical Requirements for Registration of Veterinary Medicinal... has been developed for veterinary use by the International Cooperation on Harmonisation of Technical... been undertaken by regulatory authorities and industry associations to promote the international...

75 FR 18508 - International Cooperation on Harmonisation of Technical Requirements for Registration of...

Science.gov (United States)

2010-04-12

...] International Cooperation on Harmonisation of Technical Requirements for Registration of Veterinary Medicinal... use by the International Cooperation on Harmonisation of Technical Requirements for Registration of... promote the international harmonization of regulatory requirements. FDA has participated in efforts to...

Recent progress in translational cystic fibrosis research using precision medicine strategies.

Science.gov (United States)

Cholon, Deborah M; Gentzsch, Martina

2018-03-01

Significant progress has been achieved in developing precision therapies for cystic fibrosis; however, highly effective treatments that target the ion channel, CFTR, are not yet available for many patients. As numerous CFTR therapeutics are currently in the clinical pipeline, reliable screening tools capable of predicting drug efficacy to support individualized treatment plans and translational research are essential. The utilization of bronchial, nasal, and rectal tissues from individual cystic fibrosis patients for drug testing using in vitro assays such as electrophysiological measurements of CFTR activity and evaluation of fluid movement in spheroid cultures, has advanced the prediction of patient-specific responses. However, for precise prediction of drug effects, in vitro models of CFTR rescue should incorporate the inflamed cystic fibrosis airway environment and mimic the complex tissue structures of airway epithelia. Furthermore, novel assays that monitor other aspects of successful CFTR rescue such as restoration of mucus characteristics, which is important for predicting mucociliary clearance, will allow for better prognoses of successful therapies in vivo. Additional cystic fibrosis treatment strategies are being intensively explored, such as development of drugs that target other ion channels, and novel technologies including pluripotent stem cells, gene therapy, and gene editing. The multiple therapeutic approaches available to treat the basic defect in cystic fibrosis combined with relevant precision medicine models provide a framework for identifying optimal and sustained treatments that will benefit all cystic fibrosis patients. Copyright © 2017 European Cystic Fibrosis Society. Published by Elsevier B.V. All rights reserved.

[Research progress on resources and quality evaluation of Tibetan medicine in Qinghai-Tibet Plateau].

Science.gov (United States)

Li, Xuan-Hao; Zhao, Cai-Yun; Liu, Yue; Wan, Li; Jia, Min-Ru; Xie, Cai-Xiang; Zhang, Yi

2016-02-01

With the development of Tibetan medicine industry, the demands for Tibetan medicine were rising sharply. In addition, with the eco-environment vulnerability of Qinghai-Tibet Plateau region and the phenomenon of synonymies and homonymies in Tibetan medicine, there were a lack of resources and varieties in the clinical application of Tibetan medicine. At present, the shortage of Tibetan medicine and the inadequacy of its quality standard have become the two major problems that seriously restricted the sustainable development of Tibetan medicine industry. Therefore, it is important to develop the resources investigation and quality evaluation for Tibetan medicine, which were contribute to its resources protection and sustainable utilization. In this paper, current status of resources investigation, quality standardization, artificial breeding and germplasm resources of Tibetan medicine were presented by the integrated application of the new technologies, such as DNA barcoding and 1H-NMR, which provided a reference information for resources protection, sustainable utilization, variety identification and quality standardization of Tibetan medicine resources in Qinghai-Tibet Plateau. Copyright© by the Chinese Pharmaceutical Association.

Nuclear medicine in China

International Nuclear Information System (INIS)

Wang, Shihchen; Liu, Xiujie

1986-01-01

Since China first applied isotopes to medical research in 1956, over 800 hospitals and research institutions with 4000 staff have taken up nuclear technology. So far, over 120 important biologically active materials have been measured by radioimmunoassay in China, and 44 types of RIA kit have been supplied commercially. More than 50,000 cases of hyperthyroidism have been treated satisfactorily with 131 I. Radionuclide imaging of practically all organs and systems of the human body has been performed, and adrenal imaging and nuclear cardiology have become routine clinical practice in several large hospitals. The thyroid iodine uptake test, renogram tracing and cardiac function studies with a cardiac probe are also commonly used in most Chinese hospitals. The active principles of more than 60 medicinal herbs have been labelled with isotopes in order to study the drug metabolism and mechanism of action. Through the use of labelled neurotransmitters or deoxyglucose, RIA, radioreceptor assay and autoradiography, Chinese researchers have made remarkable achievements in the study of the scientific basis of acupuncture analgesia. In 1980 the Chinese Society of Nuclear Medicine was founded, and since 1981 the Chinese Journal of Nuclear Medicine has been published. Although nuclear medicine in China has already made some progress, when compared with advanced countries, much progress is still to be made. It is hoped that international scientific exchange will be strengthened in the future. (author)

Final Technical Report

Energy Technology Data Exchange (ETDEWEB)

John Ross

2003-04-30

The Final Technical Report summarizes research accomplishments and Publications in the period of 5/1/99 to 4/30/03 done on the grant. Extensive progress was made in the period covered by this report in the areas of chemical kinetics of non-linear systems; spatial structures, reaction - diffusion systems, and thermodynamic and stochastic theory of electrochemical and general systems.

[Exploration of how to formulate guidelines on post-marketing traditional Chinese medicine surveillance].

Science.gov (United States)

Zhang, Wen; Xie, Yan-Ming; Yu, Wen-Ya

2013-09-01

Combining the world health organization's (WHO), the United States and the European union's relevant laws and guidelines on post-marketing drug surveillance to judge the status of post-marketing surveillance of traditional Chinese medicine(TCM) in China. We found that due to the late start of post-marketing surveillance of traditional Chinese medicine, the appropriate guidelines are yet to be developed. Hence, hospitals, enterprises and research institutions do not have a shared foundation from which to compare their research results. Therefore there is an urgent need to formulate such post-marketing surveillance guidelines. This paper has used as guidance various technical documents such as, "procedures to formulate national standards" and "testing methods of management in formulating traditional Chinese medicine standards" and has combined these to produce a version of post-marketing surveillance particular to Chinese medicine in China. How to formulate these guidelines is discussed and procedures and methods to formulate technical specifications are introduced. These provide a reference for future technical specifications and will assist in the development of TCM.

Progressive statistics for studies in sports medicine and exercise science.

Science.gov (United States)

Hopkins, William G; Marshall, Stephen W; Batterham, Alan M; Hanin, Juri

2009-01-01

Statistical guidelines and expert statements are now available to assist in the analysis and reporting of studies in some biomedical disciplines. We present here a more progressive resource for sample-based studies, meta-analyses, and case studies in sports medicine and exercise science. We offer forthright advice on the following controversial or novel issues: using precision of estimation for inferences about population effects in preference to null-hypothesis testing, which is inadequate for assessing clinical or practical importance; justifying sample size via acceptable precision or confidence for clinical decisions rather than via adequate power for statistical significance; showing SD rather than SEM, to better communicate the magnitude of differences in means and nonuniformity of error; avoiding purely nonparametric analyses, which cannot provide inferences about magnitude and are unnecessary; using regression statistics in validity studies, in preference to the impractical and biased limits of agreement; making greater use of qualitative methods to enrich sample-based quantitative projects; and seeking ethics approval for public access to the depersonalized raw data of a study, to address the need for more scrutiny of research and better meta-analyses. Advice on less contentious issues includes the following: using covariates in linear models to adjust for confounders, to account for individual differences, and to identify potential mechanisms of an effect; using log transformation to deal with nonuniformity of effects and error; identifying and deleting outliers; presenting descriptive, effect, and inferential statistics in appropriate formats; and contending with bias arising from problems with sampling, assignment, blinding, measurement error, and researchers' prejudices. This article should advance the field by stimulating debate, promoting innovative approaches, and serving as a useful checklist for authors, reviewers, and editors.

Technical reliability of geological disposal for high-level radioactive wastes in Japan. The second progress report. An extra issue: background of the geological disposal

International Nuclear Information System (INIS)

1999-11-01

Based on the Advisory Committee Report on Nuclear Fuel Cycle Backend Policy submitted to the Japanese Government in 1997, JNC documents the progress of research and development program in the form of the second progress report (the first one published in 1992). It summarizes an evaluation of the technical reliability and safety of the geological disposal concept for high-level radioactive wastes (HLW) in Japan. The present document, an extra issue of the progress report, was prepared for the expected readers of the report to have background information on the geological disposal. Thus it gives information about (1) generation of high-level radioactive wastes, (2) history of plans proposed for HLW disposal in Japan, and (3) procedure until the geological disposal plan is finally adopted and basic future schedules. It further discusses on such problems in HLW treatment and disposal, as for example a problem of reliable safety for a very long period. (Ohno, S.)

GT-MHR COMMERCIALZATION STUDY. TECHNICAL PROGRESS AND COST MANAGEMENT REPORT FOR THE PERIOD JUNE 1 THROUGH JUNE 30, 2003

International Nuclear Information System (INIS)

SHENOY, A.S.

2003-01-01

A271 GT-MHR COMMERCIALZATION STUDY TECHNICAL PROGRESS AND COST MANAGEMENT REPORT FOR THE PERIOD JUNE 1 THROUGH JUNE 30, 2003. Petten was provided with irradiation dimensional change data for both fuel compacts and H-451 graphite for design of the graphite sleeves that hold the fuel compacts to be irradiated in HFR-EU2. The Fuel Sample Product Specification for the Fuel Performance Irradiation Test Capsule MHR-2 was completed and approved. A Work Breakdown Structure was prepared for the development and qualification of advanced coated-particle fuels capable of meeting anticipated fuel performance requirements and work was initiated on preparation of schedules and a cost estimates for the test matrices

Electrical and Electronics Technical Team Roadmap

Energy Technology Data Exchange (ETDEWEB)

None

2013-06-01

The Electrical and Electronics Technical Team’s (EETT's) mission is to enable cost-effective, smaller, lighter, and efficient power electronics and electric motors for electric traction drive systems (ETDSs) while maintaining performance of internal combustion engine (ICE)-based vehicles. The EETT also identifies technology gaps, establishes R&D targets, develops a roadmap to achieve technical targets and goals, and evaluates the R&D progress toward meeting the established R&D targets and goals.

Nuclear technology education at the new AKR-2 of the technical university Dresden

International Nuclear Information System (INIS)

Hansen, W.; Wolf, T.; Hurtado, A.

2009-01-01

The former research and training reactor AKR-1 was completely renewed, including the peripheral technical systems and the modernization of the reactor instrumentation with digital control technology. After licensing by the local authorities the technical University Dresden has Germany's latest training reactor. Basic experiments are performed for the following disciplines: nuclear energy technology, physics, teacher training, industrial engineering, nuclear medicine. Training courses cover nuclear medicine, nuclear physics, radiation protection and reactor physics. Further tasks include research program on neutron detectors, neutron physics, radiation spectroscopy, nuclear data bases.

EVOLUTIONARY FOUNDATIONS FOR MOLECULAR MEDICINE

Science.gov (United States)

Nesse, Randolph M.; Ganten, Detlev; Gregory, T. Ryan; Omenn, Gilbert S.

2015-01-01

Evolution has long provided a foundation for population genetics, but many major advances in evolutionary biology from the 20th century are only now being applied in molecular medicine. They include the distinction between proximate and evolutionary explanations, kin selection, evolutionary models for cooperation, and new strategies for tracing phylogenies and identifying signals of selection. Recent advances in genomics are further transforming evolutionary biology and creating yet more opportunities for progress at the interface of evolution with genetics, medicine, and public health. This article reviews 15 evolutionary principles and their applications in molecular medicine in hopes that readers will use them and others to speed the development of evolutionary molecular medicine. PMID:22544168

ATR Technical Specification Upgrade Program

International Nuclear Information System (INIS)

McCracken, R.T.; Durney, J.L.; Freund, G.A.

1990-01-01

The Advanced Test Reactor (ATR) is a 250 MW, uranium-aluminum fueled test reactor which began full power operation in 1969. The initial operation was controlled by an Operating Limits document based on the original Safety Analysis Report. Additional safety bases were later developed to support Technical Specifications which were approved and implemented in 1977. The Technical Specifications which were initially developed with content and format specified in ANSI/ANS--15.1, ''The Development of Technical Specifications for Research Reactors.'' The safety basis documentation and the Technical Specifications have been updated as required to maintain them current with the ATR facility configuration. All revisions have been made with a content, format and style consistent with the original. A major, two-phase program to upgrade the content, format and style is in progress. This paper describes the first phase of this program

Technical progress report, 1 April-30 June 1981

Energy Technology Data Exchange (ETDEWEB)

None

1981-01-01

This report describes the technical accomplishments during the quarter ending June 1981, on the commercial nuclear waste management programs under the direction of the Office of Nuclear Waste Isolation (ONWI). The ONWI program is organized into 8 tasks entitled: systems, waste package, site, repository, regulatory and institutional, test facilities and excavations, land acquisition, and program management. Principal investigators in each of these areas have submitted summaries of quarterly highlights for inclusion in this report. Separate abstracts have been prepared for 5 of these tasks for inclusion in the Energy Data Base. (DMC)

Technical progress of nuclear energy: economic and environmental prospects

International Nuclear Information System (INIS)

Naudet, G.

1994-01-01

This document deals with three different aspects of the nuclear energy: first the operating and economic performances of nuclear power plants in the world, the French nuclear competitiveness. Then, the technical and economic perspectives about reactors and fuels cycle and the advantages towards atmospheric pollution are discussed to favour a new worldwide nuclear development. (TEC). 8 refs., 4 figs., 6 tabs

Nuclear medicine

International Nuclear Information System (INIS)

Kand, Purushottam

2012-01-01

Nuclear medicine is a specialized area of radiology that uses very small amounts of radioactive materials to examine organ function and structure. Nuclear medicine is older than CT, ultrasound and MRI. It was first used in patients over 60-70 years ago. Today it is an established medical specialty and offers procedures that are essential in many medical specialities like nephrology, pediatrics, cardiology, psychiatry, endocrinology and oncology. Nuclear medicine refers to medicine (a pharmaceutical) that is attached to a small quantity of radioactive material (a radioisotope). This combination is called a radiopharmaceutical. There are many radiopharmaceuticals like DTPA, DMSA, HIDA, MIBI and MDP available to study different parts of the body like kidneys, heart and bones etc. Nuclear medicine uses radiation coming from inside a patient's body where as conventional radiology exposes patients to radiation from outside the body. Thus nuclear imaging study is a physiological imaging, whereas diagnostic radiology is anatomical imaging. It combines many different disciplines like chemistry, physics mathematics, computer technology, and medicine. It helps in diagnosis and to treat abnormalities very early in the progression of a disease. The information provides a quick and accurate diagnosis of wide range of conditions and diseases in a person of any age. These tests are painless and most scans expose patients to only minimal and safe amounts of radiation. The amount of radiation received from a nuclear medicine procedure is comparable to, or often many times less than, that of a diagnostic X-ray. Nuclear medicine provides an effective means of examining whether some tissues/organs are functioning properly. Therapy using nuclear medicine in an effective, safe and relatively inexpensive way of controlling and in some cases eliminating, conditions such as overactive thyroid, thyroid cancer and arthritis. Nuclear medicine imaging is unique because it provides doctors with

Self vs expert assessment of technical and non-technical skills in high fidelity simulation.

Science.gov (United States)

Arora, Sonal; Miskovic, Danilo; Hull, Louise; Moorthy, Krishna; Aggarwal, Rajesh; Johannsson, Helgi; Gautama, Sanjay; Kneebone, Roger; Sevdalis, Nick

2011-10-01

Accurate assessment is imperative for learning, feedback and progression. The aim of this study was to examine whether surgeons can accurately self-assess their technical and nontechnical skills compared with expert faculty members' assessments. Twenty-five surgeons performed a laparoscopic cholecystectomy (LC) in a simulated operating room. Technical and nontechnical performance was assessed by participants and faculty members using the validated Objective Structured Assessment of Technical Skills (OSATS) and the Non-Technical Skills for Surgeons scale (NOTSS). Assessment of technical performance correlated between self and faculty members' ratings for experienced (median score, 30.0 vs 31.0; ρ = .831; P = .001) and inexperienced (median score, 22.0 vs 28.0; ρ = .761; P = .003) surgeons. Assessment of nontechnical skills between self and faculty members did not correlate for experienced surgeons (median score, 8.0 vs 10.5; ρ = -.375; P = .229) or their more inexperienced counterparts (median score, 9.0 vs 7.0; ρ = -.018; P = .953). Surgeons can accurately self-assess their technical skills in virtual reality LC. Conversely, formal assessment with faculty members' input is required for nontechnical skills, for which surgeons lack insight into their behaviours. Copyright © 2011 Elsevier Inc. All rights reserved.

The situation of chinese nuclear medicine technologists and strategy in future

International Nuclear Information System (INIS)

Zhang Yongxue

2001-01-01

Nuclear medicine technologists is an important part of nuclear medicine professionals, and play an important role in the progress of nuclear medicine. The professional quality of nuclear medicine technologists must adapt to the development of nuclear medicine. There is a relatively great gap between China mainland and developed countries in the field of nuclear medicine. In future, it is urgent to improve the professional quality and the educational level of nuclear medicine technologists

Nuclear theory research. Technical progress report

International Nuclear Information System (INIS)

1982-01-01

Progress is briefly described on the following studies: (1) Dirac phenomenology for deuteron elastic scattering, (2) Dirac wave functions in nuclear distorted wave calculations, (3) impulse approximation for p→p → dπ + reaction above the 3-3 resonance, (4) coherent π production, (5) nuclear potentials from Dirac bound state wavefunctions, (6) nonlocality effects in nuclear reactions, (7) unhappiness factors in DWBA description of (t,p) and (p,t) reactions, (8) absolute normalization of three-nucleon transfer reactions, (9) formulation of a finite-range CCBA computer program, (10) crossing symmetric solutions of the low equations, (11) pion scattering from quark bags, (12) study of the p 11 channel in the delta model, (13) isovector corrections in pion-nucleus scattering, (14) pionic excitation of nuclear giant resonances, and (15) isospin dependence of the second-order pion-nucleus optical potential

Nuclear Medicine week in Colombia

International Nuclear Information System (INIS)

Padhy, A.K.

2003-01-01

During the week of 6-12 October 2003 the IAEA organized a Research Coordination Meeting on 'Relationship between lower Respiratory Tract Infection, Gastroesophageal reflux and bronchial Asthma in children' at Hospital San Ignacio in Bogota. Besides there were four workshops in Bogota; workshops on Bone infection and Bone scan in Pediatric ortopaedics at Hospital Militar and Fundacion CardioInfantil, a workshop for Nuclear Medicine Technologists and a workshop on Sentinel Lymph Node mapping and Surgical Gamma Probe Application at Institute of Oncology. A nuclear cardiology workshop was organized in Medellin, and finally crowning them all was the 9th Congress of the Colombian Association of Nuclear Medicine at Cali from 10-12 October, 2003; probably the largest and best Colombian nuclear medicine congress every held in the country. A workshop was also organized in Cali for nuclear medicine technologists in conjunction with the Annual Convention. It was a mix of IAEA's Technical Cooperation and Regular Budget activities along with the activities of Colombian Association of Nuclear Medicine, bringing in absolute synergy to galvanize the entire nuclear medicine community of the country. The week saw nuclear medicine scientists from more than 20 IAEA Member States converging on Colombia to spread the message of nuclear medicine, share knowledge and to foster International understanding and friendship among the nuclear medicine people of the world

The application of biotechnology in medicinal plants breeding research in China.

Science.gov (United States)

Huang, He-Ping; Li, Jin-Cai; Huang, Lu-Qi; Wang, Dian-Lei; Huang, Peng; Nie, Jiu-Sheng

2015-07-01

Breeding is not only an important area of medicinal plants research but also the foundation for the superior varieties acquirement of medicinal plants. The rise of modern biotechnology provides good opportunities and new means for medicinal plants breeding research in China. Biotechnology shows its technical advantages and new development prospects in breeding of new medicinal plants varieties with high and stable yield, good quality, as well as stress-resistance. In this paper, we describe recent advances, problems, and development prospects about the application of modern biotechnology in medicinal plants breeding research in China.

Basalt Waste Isolation Project Technical Program Evaluation Process: a criteria-based method

International Nuclear Information System (INIS)

Babad, H.; Evans, G.C.; Wolfe, B.A.

1982-01-01

The need to objectively evaluate the progress being made by the Basalt Waste Isolation Project (BWIP) toward establishing the feasibility of siting a nuclear waste repository in basalt (NWRB) mandates a process for evaluating the technical work of the project. To assist BWIP management in the evaluation process, the Systems Department staff has developed a BWIP Technical Program Evaluation Process (TPEP). The basic process relates progress on project technical work to the SWIP Functional and System Performance Criteria as defined in National Waste Terminal Storage (MWTS) Criteria Documents. The benefits of the TPEP to BWIP and future plans for TPEP are discussed. During fiscal year (FY) 1982, TPEP wll be further formalized and further applied to the review of BWIP technical activities

Technical Progress Report on Application and Development of Appropriate Tools and Technologies for Cost-Effective Carbon Sequestration

Energy Technology Data Exchange (ETDEWEB)

Bill Stanley; Patrick Gonzalez; Sandra Brown; Jenny Henman; Ben Poulter; Sarah Woodhouse Murdock; Neil Sampson; Tim Pearson; Sarah Walker; Zoe Kant; Miguel Calmon; Gilberto Tiepolo

2006-06-30

The Nature Conservancy is participating in a Cooperative Agreement with the Department of Energy (DOE) National Energy Technology Laboratory (NETL) to explore the compatibility of carbon sequestration in terrestrial ecosystems and the conservation of biodiversity. The title of the research project is ''Application and Development of Appropriate Tools and Technologies for Cost-Effective Carbon Sequestration''. The objectives of the project are to: (1) improve carbon offset estimates produced in both the planning and implementation phases of projects; (2) build valid and standardized approaches to estimate project carbon benefits at a reasonable cost; and (3) lay the groundwork for implementing cost-effective projects, providing new testing ground for biodiversity protection and restoration projects that store additional atmospheric carbon. This Technical Progress Report discusses preliminary results of the six specific tasks that The Nature Conservancy is undertaking to answer research needs while facilitating the development of real projects with measurable greenhouse gas reductions. The research described in this report occurred between April 1st and July 30th 2006. The specific tasks discussed include: Task 1: carbon inventory advancements; Task 2: emerging technologies for remote sensing of terrestrial carbon; Task 3: baseline method development; Task 4: third-party technical advisory panel meetings; Task 5: new project feasibility studies; and Task 6: development of new project software screening tool. Work is being carried out in Brazil, Belize, Chile, Peru and the USA.

Nuclear medicine. 1 part. Manual

International Nuclear Information System (INIS)

Shlygina, O.E.; Borisenko, A.R.

2006-01-01

Current manual is urged to give wide-scale readers a submission on a key principles and methods of nuclear medicine, and it opportunities and restrictions in diagnostics and treatment of different diseases. Nuclear medicine is differing first of all by combination of diverse knowledge fields: special knowledge of a doctor, knowledge of physical processes bases, related with radiation, grounds of radiopharmaceutics, dosimetry. In the base of the book the 5th edition of 'Nuclear medicine' manual in 2 parts of German authors - Schicha, G.; Schober, O. is applied. In the book publishing the stuff of the Institute of Nuclear Physics of the National Nuclear Center of Republic of Kazakhstan has been worked. Modifications undergo practically all chapters: especially the second one, forth and sixth was enlarged. The 1 part of the book was published due to support of IAEA within the Technical cooperation project 'Implementation of Nuclear Medicine and Biophysics Center' (KAZ/6/007). The manual second part - devoted to applications of nuclear medicine methods for diagnostics and treatment - will be published in 2007

Radiation sources and technical services

International Nuclear Information System (INIS)

Stonek, K.; Satorie, Z.; Vyskocil, I.

1981-01-01

Work is briefly described of the department for sealed sources production of the Institute, including leak testing and surface contamination of sealed sources. The department also provides technical services including the inspections of sealed sources used in medicine and geology and repair of damaged sources. It carries out research of the mechanical and thermal strength of sealed sources and of the possibility of reprocessing used 226 Ra sources. The despatch department is responsible for supplying the entire country with home and imported radionuclides. The department of technical services is responsible for testing imported radionuclides, assembling materials testing, industrial and medical irradiation devices, and for the collection and storage of low-level wastes on a national scale. (M.D.)

Non-technical skills in histopathology: definition and discussion.

Science.gov (United States)

Johnston, Peter W; Fioratou, Evie; Flin, Rhona

2011-09-01

Health care is a high-risk industry, with most documented adverse incidents being associated with 'human factors' including cognitive and social skills termed 'non-technical skills'. Non-technical skills complement the diagnostic and specialist skills and professional attributes required by medical practitioners, including histopathologists, and can enhance the quality of practice and delivery of health-care services and thus contribute to patient safety. This review aims to introduce histopathologists to non-technical skills and how these pertain to everyday histopathological practice. Drawing from other domains in medicine, specifically anaesthesia and surgery, a variety of non-technical skills are identified and described in the context of histopathology to illustrate the role each plays, often collectively, in daily practice. The generic non-technical skills are defined as situation awareness, decision-making, communication, teamwork, leadership, managing stress and coping with fatigue. Example scenarios from histopathology are presented and the contributions to outcomes made by non-technical skills are explained. Consideration of these specific non-technical skills as a component in histopathology training may benefit practitioners as well as assuring patient safety. © 2011 Blackwell Publishing Limited.

Equity and Value in 'Precision Medicine'.

Science.gov (United States)

Gray, Muir; Lagerberg, Tyra; Dombrádi, Viktor

2017-04-01

Precision medicine carries huge potential in the treatment of many diseases, particularly those with high-penetrance monogenic underpinnings. However, precision medicine through genomic technologies also has ethical implications. We will define allocative, personal, and technical value ('triple value') in healthcare and how this relates to equity. Equity is here taken to be implicit in the concept of triple value in countries that have publicly funded healthcare systems. It will be argued that precision medicine risks concentrating resources to those that already experience greater access to healthcare and power in society, nationally as well as globally. Healthcare payers, clinicians, and patients must all be involved in optimising the potential of precision medicine, without reducing equity. Throughout, the discussion will refer to the NHS RightCare Programme, which is a national initiative aiming to improve value and equity in the context of NHS England.

Lifestyle medicine curriculum for a preventive medicine residency program: implementation and outcomes.

Science.gov (United States)

Nawaz, Haq; Petraro, Paul V; Via, Christina; Ullah, Saif; Lim, Lionel; Wild, Dorothea; Kennedy, Mary; Phillips, Edward M

2016-01-01

The vast majority of the healthcare problems burdening our society today are caused by disease-promoting lifestyles (e.g., physical inactivity and unhealthy eating). Physicians report poor training and lack of confidence in counseling patients on lifestyle changes. To evaluate a new curriculum and rotation in lifestyle medicine for preventive medicine residents. Training included didactics (six sessions/year), distance learning, educational conferences, and newly developed lifestyle medicine rotations at the Institute of Lifestyle Medicine, the Yale-Griffin Prevention Research Center, and the Integrative Medicine Center. We used a number of tools to assess residents' progress including Objective Structured Clinical Examinations (OSCEs), self-assessments, and logs of personal health habits. A total of 20 residents participated in the lifestyle medicine training between 2010 and 2013. There was a 15% increase in residents' discussions of lifestyle issues with their patients based on their baseline and follow-up surveys. The performance of preventive medicine residents on OSCEs increased each year they were in the program (average OSCE score: PGY1 73%, PGY2 83%, PGY3 87%, and PGY4 91%, p=0.01). Our internal medicine and preliminary residents served as a control, since they did participate in didactics but not in lifestyle medicine rotations. Internal medicine and preliminary residents who completed the same OSCEs had a slightly lower average score (76%) compared with plural for resident, preventive medicine residents (80%). However, this difference did not reach statistical significance (p=0.11). Incorporating the lifestyle medicine curriculum is feasible for preventive medicine training allowing residents to improve their health behavior change discussions with patients as well as their own personal health habits.

Lifestyle medicine curriculum for a preventive medicine residency program: implementation and outcomes

Science.gov (United States)

Nawaz, Haq; Petraro, Paul V.; Via, Christina; Ullah, Saif; Lim, Lionel; Wild, Dorothea; Kennedy, Mary; Phillips, Edward M.

2016-01-01

Background The vast majority of the healthcare problems burdening our society today are caused by disease-promoting lifestyles (e.g., physical inactivity and unhealthy eating). Physicians report poor training and lack of confidence in counseling patients on lifestyle changes. Objective To evaluate a new curriculum and rotation in lifestyle medicine for preventive medicine residents. Methods Training included didactics (six sessions/year), distance learning, educational conferences, and newly developed lifestyle medicine rotations at the Institute of Lifestyle Medicine, the Yale-Griffin Prevention Research Center, and the Integrative Medicine Center. We used a number of tools to assess residents’ progress including Objective Structured Clinical Examinations (OSCEs), self-assessments, and logs of personal health habits. Results A total of 20 residents participated in the lifestyle medicine training between 2010 and 2013. There was a 15% increase in residents’ discussions of lifestyle issues with their patients based on their baseline and follow-up surveys. The performance of preventive medicine residents on OSCEs increased each year they were in the program (average OSCE score: PGY1 73%, PGY2 83%, PGY3 87%, and PGY4 91%, p=0.01). Our internal medicine and preliminary residents served as a control, since they did participate in didactics but not in lifestyle medicine rotations. Internal medicine and preliminary residents who completed the same OSCEs had a slightly lower average score (76%) compared with plural for resident, preventive medicine residents (80%). However, this difference did not reach statistical significance (p=0.11). Conclusion Incorporating the lifestyle medicine curriculum is feasible for preventive medicine training allowing residents to improve their health behavior change discussions with patients as well as their own personal health habits. PMID:27507540

Lifestyle medicine curriculum for a preventive medicine residency program: implementation and outcomes

Directory of Open Access Journals (Sweden)

Haq Nawaz

2016-08-01

Full Text Available Background: The vast majority of the healthcare problems burdening our society today are caused by disease-promoting lifestyles (e.g., physical inactivity and unhealthy eating. Physicians report poor training and lack of confidence in counseling patients on lifestyle changes. Objective: To evaluate a new curriculum and rotation in lifestyle medicine for preventive medicine residents. Methods: Training included didactics (six sessions/year, distance learning, educational conferences, and newly developed lifestyle medicine rotations at the Institute of Lifestyle Medicine, the Yale-Griffin Prevention Research Center, and the Integrative Medicine Center. We used a number of tools to assess residents’ progress including Objective Structured Clinical Examinations (OSCEs, self-assessments, and logs of personal health habits. Results: A total of 20 residents participated in the lifestyle medicine training between 2010 and 2013. There was a 15% increase in residents’ discussions of lifestyle issues with their patients based on their baseline and follow-up surveys. The performance of preventive medicine residents on OSCEs increased each year they were in the program (average OSCE score: PGY1 73%, PGY2 83%, PGY3 87%, and PGY4 91%, p=0.01. Our internal medicine and preliminary residents served as a control, since they did participate in didactics but not in lifestyle medicine rotations. Internal medicine and preliminary residents who completed the same OSCEs had a slightly lower average score (76% compared with plural for resident, preventive medicine residents (80%. However, this difference did not reach statistical significance (p=0.11. Conclusion: Incorporating the lifestyle medicine curriculum is feasible for preventive medicine training allowing residents to improve their health behavior change discussions with patients as well as their own personal health habits.

[Standardization of names in prescriptions of traditional Chinese medicines].

Science.gov (United States)

Li, Chao-Feng; Zhang, Yu-Jun; Fan, Dong-He; Zhang, Meng-Jie; Bai, Xue; Yang, Wen-Hua; Qi, Shu-Ya; Zhang, Zhi-Jie; Xue, Chun-Miao; Mao, Liu-Ying; Cao, Jun-Ling

2017-01-01

Chinese medicine prescriptions are a type of medical documents written by doctors after they understand the patients' conditions for syndrome differentiation. Chinese medicine prescriptions are also the basis for pharmacy personnel to dispense medicines and guide patients to use drugs. It has the legal, technical and economic significances. Chinese medicine prescriptions contain such information of names, quantity and usage. Whether the names of drugs in Chinese medicine prescriptions are standardized or not is directly related to the safety and efficacy of the drugs. At present, nonstandard clinical prescriptions are frequently seen. With "Chinese medicine prescription", "names of drug in Chinese medicine prescription" and "standards of Chinese medicine prescription" as key words, the author searched CNKI, Wanfang and other databases, and consulted nearly 100 literatures, so as to summarize current names of drugs in traditional Chinese medicine prescription, analyze the reasons, and give suggestions, in the expectation of standardizing the names of drugs used in traditional Chinese medicine prescriptions. Copyright© by the Chinese Pharmaceutical Association.

Essential Medicines in National Constitutions

Science.gov (United States)

Toebes, Brigit; Hogerzeil, Hans

2016-01-01

Abstract A constitutional guarantee of access to essential medicines has been identified as an important indicator of government commitment to the progressive realization of the right to the highest attainable standard of health. The objective of this study was to evaluate provisions on access to essential medicines in national constitutions, to identify comprehensive examples of constitutional text on medicines that can be used as a model for other countries, and to evaluate the evolution of constitutional medicines-related rights since 2008. Relevant articles were selected from an inventory of constitutional texts from WHO member states. References to states’ legal obligations under international human rights law were evaluated. Twenty-two constitutions worldwide now oblige governments to protect and/or to fulfill accessibility of, availability of, and/or quality of medicines. Since 2008, state responsibilities to fulfill access to essential medicines have expanded in five constitutions, been maintained in four constitutions, and have regressed in one constitution. Government commitments to essential medicines are an important foundation of health system equity and are included increasingly in state constitutions. PMID:27781006

Technical reliability of geological disposal for high-level radioactive wastes in Japan. The second progress report. Part 3. Safety assessment for geological disposal systems

International Nuclear Information System (INIS)

1999-11-01

Based on the Advisory Committee Report on Nuclear Fuel Cycle Backend Policy submitted to the Japanese Government in 1997, JNC documents the progress of research and development program in the form of the second progress report (the first one published in 1992). It summarizes an evaluation of the technical reliability and safety of the geological disposal concept for high-level radioactive wastes (HLW) in Japan. The present document, the part 3 of the progress report, concerns safety assessment for geological disposal systems definitely introduced in part 1 and 2 of this series and consists of 9 chapters. Chapter I concerns the methodology for safety assessment while Chapter II deals with diversity and uncertainty about the scenario, the adequate model and the required data of the systems above. Chapter III summarizes the components of the geological disposal system. Chapter IV refers to the relationship between radioactive wastes and human life through groundwater, i.e. nuclide migration. In Chapter V is made a reference case which characterizes the geological environmental data using artificial barrier specifications. (Ohno. S.)

Experimental nuclear medicine

Energy Technology Data Exchange (ETDEWEB)

Dormehl, I C [Nuclear Development Corp. of South Africa (Pty.) Ltd., Pelindaba, Pretoria. Inst. of Life Sciences; Du Plessis, M; Jacobs, D J

1983-07-01

Exciting investigative research, widening the dimensions of conventional nuclear medicine, is being conducted in Pretoria where the development and evaluation of new radiopharmaceuticals in particular is attracting international attention. Additional to this, the development of new diagnostic techniques involving sophisticated data processing, is helping to place South Africa firmly in the front line of nuclear medical progress.

Review of Anti-Inflammatory Herbal Medicines

Directory of Open Access Journals (Sweden)

Mona Ghasemian

2016-01-01

Full Text Available Medicinal plants and their secondary metabolites are progressively used in the treatment of diseases as a complementary medicine. Inflammation is a pathologic condition that includes a wide range of diseases such as rheumatic and immune-mediated conditions, diabetes, cardiovascular accident, and etcetera. We introduce some herbs which their anti-inflammatory effects have been evaluated in clinical and experimental studies. Curcuma longa, Zingiber officinale, Rosmarinus officinalis, Borago officinalis, evening primrose, and Devil’s claw are some of the introduced medicinal herbs in this review. Since the treatment of inflammation is not a one-dimensional remedy, this review tries to reach a multidimensional therapeutic approach to inflammation with the help of herbal medicine and modification in lifestyle.

Defining a Progress Metric for CERT RMM Improvement

Science.gov (United States)

2017-09-14

REV-03.18.2016.0 Defining a Progress Metric for CERT-RMM Improvement Gregory Crabb Nader Mehravari David Tobar September 2017 TECHNICAL ...fendable resource allocation decisions. Technical metrics measure aspects of controls implemented through technology (systems, soft- ware, hardware...implementation metric would be the percentage of users who have received anti-phishing training . • Effectiveness/efficiency metrics measure whether

Introducing errors in progress ratios determined from experience curves

NARCIS (Netherlands)

van Sark, W.G.J.H.M.

2008-01-01

Progress ratios (PRs) derived from historical data in experience curves are used for forecasting development of many technologies as a means to model endogenous technical change in for instance climate–economy models. These forecasts are highly sensitive to uncertainties in the progress ratio. As a

The Basalt Waste Isolation Project technical program evaluation process: A criteria-based method

International Nuclear Information System (INIS)

Babad, H.; Evans, C.; Wolfe, B.A.

1982-01-01

The need to objectively evaluate the progress being made by the Basalt Waste Isolation Project (BWIP) toward establishing the feasibility of siting a nuclear waste repository in basalt (NWRB) mandates a process for evaluating the technical work of the project. To assist BWIP management in the evaluation process, the Systems Department staff has developed a BWIP Technical Program Evaluation Process (TPEP). The basic process relates progress on project technical work to the BWIP Functional and System Performance Criteria as defined in National Waste Terminal Storage (NWTS) Criteria Documents. The benefits of the TPEP to BWIP and future plans for TPEP are discussed. During fiscal year (FY) 1982, TPEP will be further formalized and further applied to the review of BWIP technical activities

The progress test of medicine: the Dutch experience

NARCIS (Netherlands)

Tio, R.A.; Schutte, B.; Meiboom, A.A.; Greidanus, J.; Dubois, E.A.; Bremers, A.J.

2016-01-01

Progress testing in the Netherlands has a long history. It was first introduced at one medical school which had a problem-based learning (PBL) curriculum from the start. Later, other schools with and without PBL curricula joined. At present, approximately 10,000 students sit a test every three

Infrared thermography in veterinary medicine

International Nuclear Information System (INIS)

Hudak, R.; Zivcak, J.; Sevcik, A.; Danko, J.

2008-01-01

The use of infrared thermography in veterinary medicine has been practiced since at least the 1960's, but it is only now, in approximately the last 5 years, that it has been viewed with a reasonably open mind in the veterinary community at large. One of the reasons is progress in sensors technology, which contributed for an outstanding improvement of the thermal imager parameters. Paper deals with veterinary thermography and with description of applications at the University of Veterinary Medicine in Kosice. (authors)

[Research Progress on Forensic Entomotoxicology].

Science.gov (United States)

Liu, Zhi-jiang; Zhai, Xian-dun; Guan, Ling; Mo, Yao-nan

2015-06-01

Forensic entomotoxicology is a branch of forensic medicine, which applies entomology, toxicology and other related studies to solve the poisoning cases. It has an obvious advantage in the investigation on poisoning death. Based on the expounding definition and research of entomotoxicology, this paper reviews research progress and application value in some aspects of forensic medicine, such as the effects of drugs/toxins on the growth and development of sarcosaphagous insects and the qualitative and quantitative analysis of the drugs/toxins in the poisoned body tissue.

Feed-in tariffs versus quotas: how to promote renewable s and stimulate technical progress for cost decrease?

International Nuclear Information System (INIS)

Menanteau, Ph.; Finon, D.; Lamy, M.L.

2002-01-01

Incentive schemes for the development of renewable energy sources may focus on quantities (defining national targets and setting up bidding systems, or quota systems providing for green certificate trading), or they may focus on prices (feed-in tariffs). Whatever the system chosen, the role of the public authorities is quite specific: to stimulate technical progress and speed up the technological learning processes so that ultimately renewable energy technologies will be able to compete with conventional technologies, once the environmental costs have been internalized. A comparison of instruments must thus take into account the characteristics of the innovation process and adoption conditions (uncertainties regarding cost curves, learning effects) which means also looking at dynamic efficiency criteria. The paper concludes that a system of feed-in tariffs is more efficient than a bidding system, but highlights the theoretical interest of green certificate trading which must be confirmed through practice, given the influence of market structures and rules on the performance of this type of approach. (author)

Evaluating M.D.-Level Competence in Internal Medicine.

Science.gov (United States)

Anderson, Alexander S.; Botticelli, Max G.

1981-01-01

The implementation of a clinical clerkship in internal medicine that was flexible in time required that a new evaluation program be developed to assess the progress of students. The progress of the classes of 1979 and 1980 toward achievement of predetermined levels of mastery is presented. (Author/MLW)

Progress report for 1978-79, Technical Physics Division

International Nuclear Information System (INIS)

Gopalaraman, C.P.; Deshpande, R.Y.

1980-01-01

The research and development activities of the Technical Physics Division (TPD) of the Bhabha Atomic Research Centre, Bombay, during the calendar years 1978 and 1979 are reported. The TPD's major areas of work are electronics instrumentation, crystal technology, mass spectrometers, cryogenic equipment and vacuum equipment. Some of the major achievements are: (1) fabrication of various electronic instruments and components for the pulsed nuclear magnetic resonance spectrometers, (2) growth of large size NaI(Tl) and Ge crystals, (3) growth of CsI, KDP and arsenic selenide crystals, (4) fabrication of quadrupole mass filters and (5) fabrication of mass spectrometers for gas analysis and D/H analysis in water samples. (M.G.B.)

Enhancing health care non-technical skills: the TINSELS programme.

Science.gov (United States)

Gordon, Morris; Box, Helen; Halliwell, Jo-Anne; Farrell, Michael; Parker, Linda; Stewart, Alison

2015-12-01

Training in 'non-technical skills', i.e. social (communication and teamwork) and cognitive (analytical and personal behaviour) skills, in health care have been of great interest over the last decade. Whereas the majority of publications focus on 'whether' such education can be successful, they overlook 'how' they enhance skills. We designed and piloted a theoretically robust teaching package that addresses non-technical skills in the context of medicine safety through simulation-based interprofessional learning: the Training In Non-technical Skills to Enhance Levels of Medicines Safety (TINSELS) programme. A modified Delphi process was completed to identify learning outcomes, and multi-professional teams were recruited through local publicity. The faculty staff developed a three-session simulation-based intervention: firstly, a simulated ward encounter with multiple medicine-related activities; secondly, an extended debriefing and facilitated discussion; and finally, a 'chamber of horrors', where interprofessional teams identified potential sources of error. Each session was completed in the simulation suite with between six and nine participants, lasted approximately 90 minutes and took place over 2 weeks. Full details of the course will be presented to facilitate dissemination. Training in 'non-technical skills' in health care have been of great interest over the last decade Feedback was collected on a Likert scale after the course (1, strongly disagree; 5, strongly agree). Mean scores were all greater than 4, with qualitative feedback noting the fidelity of the authentic interprofessional groups. A previously validated safety attitudes questionnaire found changes in attitudes towards handover of care and perceptions of safety in the workplace. An original, simulation-based, multi-professional training programme has been developed with learning and assessment materials available for widespread replication. © 2015 John Wiley & Sons Ltd.

Sources of technical assistance

International Nuclear Information System (INIS)

Laue, H.J.

1977-01-01

This paper shows examples of technical assistance programmes within bilateral cooperation agreements between the Federal Republic of Germany and a number of developing countries of very different characteristics and summarizes the possibilities of technical assistance granted by international organizations, such as IAEA, UNDP, etc. A basic requirement for a successful transfer of technology is a high knowledge level of the indigenous scientists and engineers. Therefore, programmes for training and education and for information exchange are presented. Based on these, the means and methods of planning, performance and quality assurance are explained by practical examples and are related to the progress achieved in the use of nuclear energy and in establishing a national industry in the developing countries. (orig.) [de

Nephrotoxicity and Chinese Herbal Medicine.

Science.gov (United States)

Yang, Bo; Xie, Yun; Guo, Maojuan; Rosner, Mitchell H; Yang, Hongtao; Ronco, Claudio

2018-04-03

Chinese herbal medicine has been practiced for the prevention, treatment, and cure of diseases for thousands of years. Herbal medicine involves the use of natural compounds, which have relatively complex active ingredients with varying degrees of side effects. Some of these herbal medicines are known to cause nephrotoxicity, which can be overlooked by physicians and patients due to the belief that herbal medications are innocuous. Some of the nephrotoxic components from herbs are aristolochic acids and other plant alkaloids. In addition, anthraquinones, flavonoids, and glycosides from herbs also are known to cause kidney toxicity. The kidney manifestations of nephrotoxicity associated with herbal medicine include acute kidney injury, CKD, nephrolithiasis, rhabdomyolysis, Fanconi syndrome, and urothelial carcinoma. Several factors contribute to the nephrotoxicity of herbal medicines, including the intrinsic toxicity of herbs, incorrect processing or storage, adulteration, contamination by heavy metals, incorrect dosing, and interactions between herbal medicines and medications. The exact incidence of kidney injury due to nephrotoxic herbal medicine is not known. However, clinicians should consider herbal medicine use in patients with unexplained AKI or progressive CKD. In addition, exposure to herbal medicine containing aristolochic acid may increase risk for future uroepithelial cancers, and patients require appropriate postexposure screening. Copyright © 2018 by the American Society of Nephrology.

Geothermal progress monitor. Progress report No. 3, March-April 1980

Energy Technology Data Exchange (ETDEWEB)

1980-01-01

Progress is reviewed in the following areas: electric uses; direct heat uses; drilling activities; exploration; leases; outreach and technical assistance; feasibility studies and application demonstrations; geothermal loan guarantee program; general activities; R and D activities; legal, institutional, and regulatory activities; environmental activities; and state, local, and private sector activities. Also included are a list of reports and publications and a directory of individuals in the geothermal community. (MHR)

Index of International Publications in Aerospace Medicine

Science.gov (United States)

2010-10-01

Aerospace Medicine technical reports are available in full-text from the Civil Aerospace Medical Institute’s publications Web site: www.faa.gov/library...System in Space and Other Extreme Conditions. England – USA: Harwood Academic Publishers, 1991. Konstantinova IV, Petrov RV. Sistema Immuniteta v

A manual of nuclear medicine procedures

International Nuclear Information System (INIS)

Das, B.K.; Noreen Norfaraheen Lee Abdullah

2012-01-01

Nuclear medicine is a fast growing specialty. The procedures provide quantitative parameters of organ functions required for modern practice of medicine. With the development of new machines and increased application of computer software, the procedures are under continuous change. Some procedures have become outdated or redundant while new methods have been introduced to enhance the quality of information obtained from a particular application. Although there are a few books published abroad to inform doctors and technical staff about the procedures, a comprehensive source to give quick information about how different test are performed, particularly the new developments and the expected outcome both in normal and abnormal cases has been a long felt need. The physician ordering a Nuclear Medicine test also needs to know what patient preparations are required for optimal results, how to satisfy the queries of the patient particularly in respect of radiation exposure which sometimes can be a major concern of the patient. This manual has been prepared not only to describe technical details of various procedures that are currently practiced in Nuclear Medicine, but also to provide quick information for the doctors and health care personnel on how to inform the patients about the investigation for which they are being referred and how to interpret the results. Since there is no such comprehensive book published yet in Asia including South-East Asia, it is likely to be in great demand in the region. All students of Master Degree, M.D., DRM, DMRIT, M.Sc. (Nuclear Medicine) and technologists already working in various diagnostic centers will likely buy this book. General practitioners and specialists who refer patients for different radioisotope investigations may find this book useful for quick reference. (author)

Current Status and Future Perspective in the Globalization of Traditional Chinese Medicines

Directory of Open Access Journals (Sweden)

Wan-Ying Wu

2015-01-01

Full Text Available Globalization of traditional Chinese medicines started around 1996, which was initiated by the Chinese government. However, substantial progress was only achieved in recent years including the adoption of TCM quality monographs in the western pharmacopoeias (United States Pharmacopoeia and European Pharmacopoeia and registration in main stream drug regulatory agencies such as US Food and Drug Administration (FDA and European Medicines Agency (EMA. So far, several TCM herbal quality monographs were adopted by the United States Pharmacopoeia including Chinese Salvia, Ganoderma lucidum and Panax notoginseng, etc. Over 45 TCM quality monographs were recorded in the European Pharmacopoeia with 20 more in progress. After the successful registration of the first TCM product named Diao Xin Xue Kang as traditional medicine via the Medicines Evaluation Board of the Netherlands, several other TCM herbal products are in the registration process in several European member states. So far, there has been still not any TCM product authorized as a drug by the FDA regardless of a few TCM products in phase III or phase II clinical trials. This review summarizes the progress made in the globalization of traditional Chinese medicines in recent years and future issues in this regard.

River Protection Project waste feed delivery program technical performance measurement assessment plan

International Nuclear Information System (INIS)

O'TOOLE, S.M.

1999-01-01

This plan establishes a formal technical performance-monitoring program. Technical performance is assessed by establishing requirements based performance goals at the beginning of a program and routinely evaluating progress in meeting these goals at predetermined milestones throughout the project life cycle

Integral Fast Reactor Program annual progress report, FY 1994

International Nuclear Information System (INIS)

Chang, Y.I.; Walters, L.C.; Laidler, J.J.; Pedersen, D.R.; Wade, D.C.; Lineberry, J.J.

1994-12-01

This report summarizes highlights of the technical progress made in the Integral Fast Reactor (IFR) Program in FY 1994. Technical accomplishments are presented in the following areas of the IFR technology development activities: metal fuel performance; pyroprocess development; safety experiments and analyses; core design development; fuel cycle demonstration; and LMR technology R ampersand D

Nuclear medicine program progress report for quarter ending December 31, 1996

Energy Technology Data Exchange (ETDEWEB)

Knapp, F.F. Jr.; Beets, A.L.; Boll, R.; Luo, H.; McPherson, D.W.; Mirzadeh, S.

1997-03-20

In this report the authors describe the use of an effective method for concentration of the rhenium-188 bolus and the results of the first Phase 1 clinical studies for bone pain palliation with rhenium-188 obtained from the tungsten-188/rhenium-188 generator. Initial studies with therapeutic levels of Re-188-HEDP at the Clinic for Nuclear Medicine at the University of Bonn, Germany, have demonstrated the expected good metastatic uptake of Re-188-HEDP in four patients who presented with skeletal metastases from disseminated prostatic cancer with good pain palliation and minimal marrow suppression. In addition, skeletal metastatic targeting of tracer doses of Re-188(V)-DMSA has been evaluated in several patients with metastases from prostatic cancer at the Department of Nuclear Medicine at the Canterbury and Kent Hospital in Canterbury, England. In this report the authors also describe further studies with the E-(R,R)-IQNP ligand developed in the ORNL Nuclear Medicine Program as a potential imaging agent for detection of changes which may occur in the cerebral muscarinic-cholinergic receptors (mAChR) in Alzheimer`s and other diseases.

Geothermal direct-heat utilization assistance. Quarterly project progress report, April--June 1993

Energy Technology Data Exchange (ETDEWEB)

Lienau, P.

1993-06-01

Technical assistance was provided to 60 requests from 19 states. R&D progress is reported on: evaluation of lineshaft turbine pump problems, geothermal district heating marketing strategy, and greenhouse peaking analysis. Two presentations and one tour were conducted, and three technical papers were prepared. The Geothermal Progress Monitor reported: USGS Forum on Mineral Resources, Renewable Energy Tax Credits Not Working as Congress Intended, Geothermal Industry Tells House Panel, Newberry Pilot Project, and Low-Temperature Geothermal Resources in Nevada.

The Current Status and Future Perspectives of Nuclear Medicine in Korea

International Nuclear Information System (INIS)

Lee, Myung Chul; Oh, So Won; Chung, June Key; Lee, Dong Soo

2010-01-01

Since the introduction of nuclear medicine in 1959, Korea accomplished a brilliant development in terms of both clinical practice and research activities, which was mainly due to the dedication of nuclear medicine specialists, consisting of physicians, technicians, and scientists, and strong support from the Korean Government. Now, Korea has 150 medical institutes, performing approximately 561,000 nuclear imaging procedures and 11.6 million in vitro studies in 2008, and ranked fourth in the number of presentations at the Annual Meeting of the Society of Nuclear Medicine (SNM) in 2008. The successful progress in this field has allowed Korea to focus on the international promotion of nuclear medicine, especially in the developing and underdeveloped countries. In consequence, the Asian Regional Cooperative Council for Nuclear Medicine (ARCCNM) was established in 2001, and Seoul hosted the 9th Congress of the World Federation of Nuclear Medicine and Biology (WFNMB) in 2006. In the future, Korea will strive to sustain its rate of advancement in the field and make every effort to share its progress and promote the exchange of scientific information at the international level.

Geothermal direct-heat utilization assistance. Quarterly progress report, April--June 1993

Energy Technology Data Exchange (ETDEWEB)

1993-08-01

Progress is reported on the following R&D activities: evaluation of lineshaft turbine pump problems, geothermal district heating marketing strategy, and greenhouse peaking analysis. Other activities are reported on technical assistance, technology transfer, and the geothermal progress monitor.

Integral Fast Reactor Program. Annual progress report, FY 1992

Energy Technology Data Exchange (ETDEWEB)

Chang, Y.I.; Walters, L.C.; Laidler, J.J.; Pedersen, D.R.; Wade, D.C.; Lineberry, M.J.

1993-06-01

This report summarizes highlights of the technical progress made in the Integral Fast Reactor (IFR) Program in FY 1992. Technical accomplishments are presented in the following areas of the IFR technology development activities: (1) metal fuel performance, (2) pyroprocess development, (3) safety experiments and analyses, (4) core design development, (5) fuel cycle demonstration, and (6) LMR technology R&D.

Nanotechnology in medicine: concepts and concerns

International Nuclear Information System (INIS)

Cancino, Juliana; Marangoni, Valeria S.; Zucolotto, Valtencir

2014-01-01

The recent advances in the development of nanomaterials have opened new and exciting opportunities for their applications in medicine. These applications include molecular imaging, drug-delivery, and photothermal therapy. Despite the progress in medicinal applications of nanomaterials, several key problems remain unaddressed. Recent advances in this area include the enhancement of sensitivity in early diagnosis and therapy, in addition to investigations into the possible toxicity of nanomaterials. However, since little is known about the toxicity of nanomaterials, the regulation of these materials is a slow and complex process. This paper reviews the current scenario in the applications of nanomaterials in medicine as well as the main concerns and regulatory questions. (author)

Aspects and progresses of the Program for Regulatory Inspection of Nuclear Medicine in Brazil

International Nuclear Information System (INIS)

Alves, Carlos Eduardo Gonzalez Ribeiro

2004-01-01

This work aims to show the advances in the Nuclear Medicine auditing field performed by the Nuclear Medicine Group of the Division of Radiotherapy and Nuclear Medicine of the Inst. of Radiation Protection and Dosimetry. The main aspects observed during the auditing are presented as well as the evolution of the non-conformities. It is shown that the occurrence of these non-conformities decreases year by year, primarily as a function of the severity of the auditing and the consciousness of the personal of Nuclear Medicine Services. Results point clearly to the importance of the coercion actions to guarantee a radiation protection level in compliance with the standards established by the Brazilian Nuclear Energy Commission. (author)

Gatlinburg conference: barometer of progress in analytical chemistry

International Nuclear Information System (INIS)

Shults, W.D.

1981-01-01

Much progress has been made in the field of analytical chemistry over the past twenty-five years. The AEC-ERDA-DOE family of laboratories contributed greatly to this progress. It is not surprising then to find a close correlation between program content of past Gatlinburg conferences and developments in analytical methodology. These conferences have proved to be a barometer of technical status

[Palliativer medicine in surgery].

Science.gov (United States)

Gutiérrez Samperio, César; Ruiz Canizales, Raúl; Arellano Rodríguez, Salvador; Romero Zepeda, Hilda; Hall, Robert T; García Camino, Bernardo

The concepts and background of palliative medicine, the patient-health team relationship and the right of the patients to receive palliative care, its application in surgery, the criterion defining the terminally ill, proportionate and disproportionate measures, where it is applied and what this consists of, drugs and procedures used, who should administrate them and for how long, the requirements for advanc directives and avoidance of therapeutic obstinacy, were reviewed. It describes and reflects their ethical and legal bases. It describes the main changes to the law in México in 2009 and 2012. It concludes that palliative medicine is not against scientific and technological progress, but promotes its appropriate use with respect to the will and dignity of the patient. It should be applied by a multidisciplinary team, who accompany the patient throughout the progression of their condition, strengthening the doctor's and health team's relationship with the patients and their families. Copyright © 2016 Academia Mexicana de Cirugía A.C. Publicado por Masson Doyma México S.A. All rights reserved.

Technical reliability of geological disposal for high-level radioactive wastes in Japan. The second progress report. Part 2. Engineering technology for geological disposal

International Nuclear Information System (INIS)

1999-11-01

Based on the Advisory Committee Report on Nuclear Fuel Cycle Backend Policy submitted to the Japanese Government in 1997, JNC documents the progress of research and development program in the form of the second progress report (the first one published in 1992). It summarizes an evaluation of the technical reliability and safety of the deep geological disposal concept for high-level radioactive wastes (HLW) in Japan. The present document, part 2 of the progress report, concerns engineering aspect with reference to Japanese geological disposal plan, according to which the vitrified HLW will be disposed of into a deep, stable rock mass with thick containers and surrounding buffer materials at the depth of several hundred meters. It discusses on multi-barrier systems consisting of a series of engineered and natural barriers that will isolate radioactive nuclides effectively and retard their migrations to the biosphere environment. Performance of repository components, including specifications of containers for vitrified HLW and their overpacks under design as well as buffer material such as Japanese bentonite to be placed in between are described referring also to such possible problems as corrosion arising from the supposed system. It also presents plans and designs for underground disposal facilities, and the presumed management of the underground facilities. (Ohno, S.)

Robotics in medicine

Science.gov (United States)

Kuznetsov, D. N.; Syryamkin, V. I.

2015-11-01

Modern technologies play a very important role in our lives. It is hard to imagine how people can get along without personal computers, and companies - without powerful computer centers. Nowadays, many devices make modern medicine more effective. Medicine is developing constantly, so introduction of robots in this sector is a very promising activity. Advances in technology have influenced medicine greatly. Robotic surgery is now actively developing worldwide. Scientists have been carrying out research and practical attempts to create robotic surgeons for more than 20 years, since the mid-80s of the last century. Robotic assistants play an important role in modern medicine. This industry is new enough and is at the early stage of development; despite this, some developments already have worldwide application; they function successfully and bring invaluable help to employees of medical institutions. Today, doctors can perform operations that seemed impossible a few years ago. Such progress in medicine is due to many factors. First, modern operating rooms are equipped with up-to-date equipment, allowing doctors to make operations more accurately and with less risk to the patient. Second, technology has enabled to improve the quality of doctors' training. Various types of robots exist now: assistants, military robots, space, household and medical, of course. Further, we should make a detailed analysis of existing types of robots and their application. The purpose of the article is to illustrate the most popular types of robots used in medicine.

Technical Standards for Nursing Education Programs in the 21st Century.

Science.gov (United States)

Ailey, Sarah H; Marks, Beth

The Institute of Medicine (2000, 2002) exposed serious safety problems in the health system and called for total qualitative system change. The Institute of Medicine (2011, 2015) also calls for improving the education of nurses to provide leadership for a redesigned health system. Intertwined with improving education is the need to recruit and retain diverse highly qualified students. Disability is part of diversity inclusion, but current technical standards (nonacademic requirements) for admission to many nursing programs are a barrier to the entry of persons with disabilities. Rehabilitation nurse leaders are in a unique position to improve disability diversity in nursing. The purpose of this paper is to discuss the importance of disability diversity in nursing. The history of existing technical standards used in many nursing programs is reviewed along with examples. On the basis of the concept that disability inclusion is a part of diversity inclusion, we propose a new model of technical standards for nursing education. Rehabilitation nurse leaders can lead in eliminating barriers to persons with disabilities entering nursing.

Technical progress report for the quarter 1 October-31 December 1980

International Nuclear Information System (INIS)

1981-01-01

This report describes the technical accomplishments on the commercial nuclear waste management programs and on the geologic disposal of nuclear wastes. The program is organized into eight tasks: systems, waste package, site, repository, regulatory and institutional, test facilities and excavations, land acquisition, and program management

Development of TRITN : In-house technical information network of Technical Research Institute in The Chugoku Electric Power Co., Inc.

Science.gov (United States)

Ebara, Hisao

With the increase in information amount, progress in information network, diversified technology and change in in-house organization the Technical Research Institute has necessitated to shift the conventional technical database processing by use of personal computers into new system promised for future use. It enables to; provide classification system which meets the needs of the institute; execute distributed processing using workstations; make the low cost processing using commercial softwares; make networks using LAN, WAN personal computer communication, and provide primary materials (text data) on facsimiles using optical disks. Such features are those of technical information database system "TRITN" which is available to any persons and at any time. This paper describes how TRITN was developed and the system outline.

Office of Waste Isolation progress report, October 1976

International Nuclear Information System (INIS)

1977-01-01

Progress of the National Waste Terminal Storage program is reported under: technical projects, facility projects, systems projects, and regulatory affairs. Various media (salt, shales, rocks) for geologic storage are covered

Research progress on high altitude retinopathy and application of Traditional Chinese Medicine

Directory of Open Access Journals (Sweden)

Hai-Xiang Huang

2014-11-01

Full Text Available High altitude retinopathy(HARrefers to the body which can't adapt to the hypobaric hypoxia environment at high altitude leading to retinal diseases, which typically manifested as retinal hemorrhages, optic disc edema and cotton wool spots. With the development of high altitude medicine, HAR become a hot topic of eye research in recent years. New researches show a significantly higher incidence of HAR, and HAR has a close contact with acute mountain sickness, high altitude cerebral edema and high altitude pulmonary edema. A further study in pathogenesis and prevention measures of HAR will promote the prevention of altitude sickness. Traditional Chinese Medicine has achieved good effects in the prevention of altitude sickness, but the effect and mechanism of herbs on HAR has not been reported. Through read and summarize the relevant literatures and reports, the author will give an overview of the research advances on HAR's pathogenesis and application of Traditional Chinese Medicine.

Holistic pediatric veterinary medicine.

Science.gov (United States)

Pesch, Lisa

2014-03-01

Holistic veterinary medicine treats the whole patient including all physical and behavioral signs. The root cause of disease is treated at the same time as accompanying clinical signs. Herbal and nutritional supplements can help support tissue healing and proper organ functioning, thereby reducing the tendency of disease progression over time. Proper selection of homeopathic remedies is based on detailed evaluation of clinical signs. Herbal medicines are selected based on organ(s) affected and the physiologic nature of the imbalance. Many herbal and nutraceutical companies provide support for veterinarians, assisting with proper formula selection, dosing, drug interactions, and contraindications. Copyright © 2014 Elsevier Inc. All rights reserved.

Teaching non-technical (professional) competence in a veterinary school curriculum.

Science.gov (United States)

Burns, Gilbert A; Ruby, Kathleen L; Debowes, Richard M; Seaman, Susan J; Brannan, Julia K

2006-01-01

Data from focused studies and comprehensive surveys suggest that developing or enhancing non-technical (professional) skills will result in a more satisfied and successful veterinary student or veterinary graduate. The College of Veterinary Medicine at Washington State University has devoted considerable time, effort, and resources to augmenting the non-technical aspects of its curriculum while maintaining the traditional strengths of its DVM program. Here we summarize pertinent research and best-practice recommendations from a variety of sources and outline the steps that have been taken, with the underlying rationales, to integrate the teaching and modeling of non-technical (professional) competence throughout a four-year course of veterinary study.

Annual technical progress report: reactor safety, Government fiscal year 1978

International Nuclear Information System (INIS)

1978-01-01

Progress in LMFBR safety studies on accident debris behavior is reported under the following subtask titles: high-temperature-concentration aerosols, large-scale molten fuel tests, sodium release tests, and risk analysis

[Innovation guidelines and strategies for pharmaceutical engineering of Chinese medicine and their industrial translation].

Science.gov (United States)

Cheng, Yi-Yu; Qu, Hai-Bin; Zhang, Bo-Li

2013-01-01

This paper briefly analyzes the bottlenecks and major technical requirements for pharmaceutical industry of Chinese medicine, providing current status of pharmaceutical engineering of Chinese medicine. The innovation directions and strategies of the pharmaceutical engineering for manufacturing Chinese medicine are proposed along with the framework of their core technology. As a consequence, the development of the third-generation pharmaceutical technology for Chinese medicine, featured as "precision, digital and intelligent", is recommended. The prospects of the pharmaceutical technology are also forecasted.

Recent progress in sodium technology

Energy Technology Data Exchange (ETDEWEB)

Hallett, W. J.

1963-10-15

Progress over the past year in U. S. laboratories studying some of the materials and engineering problems that must be resolved in bringing the technology of sodium to an economically and technically attractive point is reviewed. The status of sodium cooled power reactors in the U. S. is described. (P.C.H.)

1984-85 ISN progress report

International Nuclear Information System (INIS)

1985-01-01

This progress report ISN 1984-1985 deals with the following subjects: nuclear physics theory, peripheral and intermediate energy physics, characteristics of reaction mechanisms in heavy ion collisions, nuclear structure, fundamental interactions, experimental methods and new instrumentation, some interdisciplinary research activities and technical activities, the SARA cyclotron and finally, technology transfer and valorisation [fr

Instrumentation of dynamic gas pulse loading system. Technical progress report, first quarter 1992

Energy Technology Data Exchange (ETDEWEB)

Mohaupt, H.

1992-04-14

The overall goal of this work is to further develop and field test a system of stimulating oil and gas wells, which increases the effective radius of the well bore so that more oil can flow into it, by recording pressure during the gas generation phase in real time so that fractures can be induced more predictably in the producing formation. Task 1: Complete the laboratory studies currently underway with the prototype model of the instrumentation currently being studied. Task 2: Perform field tests of the model in the Taft/Bakersfield area, utilizing operations closest to the engineers working on the project, and optimize the unit for various conditions encountered there. Task 3: Perform field test of the model in DGPL jobs which are scheduled in the mid-continent area, and optimize the unit for downhole conditions encountered there. Task 4: Analyze and summarize the results achieved during the complete test series, documenting the steps for usage of downhole instrumentation in the field, and compile data specifying use of the technology by others. Task 5: Prepare final report for DOE, and include also a report on the field tests completed. Describe and estimate the probability of the technology being commercialized and in what time span. The project has made substantial technical progress, though we are running about a month behind schedule. Expenditures are in line with the schedule. Increased widespread interest in the use of DGPL stimulation has kept us very busy. The computer modeling and test instrumentation developed under this program is already being applied to commercial operations.

The BGO collaboration progress report 1990

International Nuclear Information System (INIS)

Anon.

1990-01-01

A large solid angle BGO calorimeter is under contruction for photo-nuclear experiments at intermediate energy facilities. In this note the status progress of the project, the technical steps undertaken in the construction of the apparatus and the goals of this initiative are reviewed

Are Allopathic and Holistic Medicine Incommensurable?

Science.gov (United States)

Evangelatos, Nikolaos; Eliadi, Irini

2016-01-01

The shift from the Aristotelian to the Newtonian scientific paradigm gave birth to progresses in the natural, hard sciences and contributed to the emergence of modernity. Allopathic medicine gradually implemented those progresses, transforming itself into contemporary biomedicine. In the early 20th century, replacement of Newtonian physics by quantum mechanics and Einstein's theory of relativity resulted in a new paradigm shift in the natural, hard sciences. This shift gave birth to post-modern perceptions, which attempt to put those changes in context. Within this new context, holistic therapeutic approaches are considered more compatible with the new paradigm. Different paradigms in the natural, hard sciences are considered to be incommensurable (in the Kuhnian sense). This incommensurability is also transferred to the different societal contexts, the different «Weltanschauungen» that rely on different scientific paradigms. However, drawing on arguments that range from historical and philosophical to practical and sociological ones, we argue that, although based on different scientific paradigms, allopathic and holistic medicine are not incommensurable, but rather complementary. This may be related to the inherent attributes of medicine, a fact that reinforces the debate on its epistemological status. © 2016 S. Karger GmbH, Freiburg.

Savannah River Plant, Works Technical Department monthly progress report for March 1956

International Nuclear Information System (INIS)

1956-01-01

This document details activities of the Works Technical Department during the month of March 1956. It covers reactor technology, separations technology, engineering assistance and heavy water technology

Induced pluripotent stem cell technology: a decade of progress.

Science.gov (United States)

Shi, Yanhong; Inoue, Haruhisa; Wu, Joseph C; Yamanaka, Shinya

2017-02-01

Since the advent of induced pluripotent stem cell (iPSC) technology a decade ago, enormous progress has been made in stem cell biology and regenerative medicine. Human iPSCs have been widely used for disease modelling, drug discovery and cell therapy development. Novel pathological mechanisms have been elucidated, new drugs originating from iPSC screens are in the pipeline and the first clinical trial using human iPSC-derived products has been initiated. In particular, the combination of human iPSC technology with recent developments in gene editing and 3D organoids makes iPSC-based platforms even more powerful in each area of their application, including precision medicine. In this Review, we discuss the progress in applications of iPSC technology that are particularly relevant to drug discovery and regenerative medicine, and consider the remaining challenges and the emerging opportunities in the field.

Technical progress report for the quarter 1 October-31 December 1980

Energy Technology Data Exchange (ETDEWEB)

1981-01-01

This report describes the technical accomplishments on the commercial nuclear waste management programs and on the geologic disposal of nuclear wastes. The program is organized into eight tasks: systems, waste package, site, repository, regulatory and institutional, test facilities and excavations, land acquisition, and program management. (DLC)

TECHNICAL COORDINATION

CERN Multimedia

Austin Ball

2013-01-01

  Since the last report, much visible progress has been made, as the LS1 programme approaches the halfway point. From early October, technical and safety shift-crew have been present around the clock, allowing detectors to stay switched on overnight, ensuring that safety systems are operational and instructions for non-expert shift-crew are clear. LS1 progress Throughout the summer, whilst the solenoid vacuum tank and YB0 surfaces were accessible, an extensive installation programme took place to prepare for Tracker colder operation and the PLT installation, in 2014, the Phase 1 Pixel Tracker installation, in 2016–’17, and the HCAL Phase 1 upgrade completion, ending in LS2. This included pipework for N2 or dry air to flush the Tracker bulkhead region, many sensors to monitor temperature and dew point in the Tracker and its service channels, heating wires outside the Tracker cooling bundles, supports for the new vacuum-jacketed, concentric, CO2 Pixel cooling lines, the PLT cool...

Progress and status of the Integral Fast Reactor (IFR) fuel cycle development

International Nuclear Information System (INIS)

Till, C.E.; Chang, Y.I.

1993-01-01

The Integral Fast Reactor (IFR) fuel cycle holds promise for substantial improvements in economics, diversion-resistance, and waste management. This paper discusses technical features of the IFR fuel cycle, its technical progress, the development status, and the future plans and directions

Progress and status of the Integral Fast Reactor (IFR) fuel cycle development

Energy Technology Data Exchange (ETDEWEB)

Till, C.E.; Chang, Y.I.

1993-03-01

The Integral Fast Reactor (IFR) fuel cycle holds promise for substantial improvements in economics, diversion-resistance, and waste management. This paper discusses technical features of the IFR fuel cycle, its technical progress, the development status, and the future plans and directions.

Progress and status of the Integral Fast Reactor (IFR) fuel cycle development

Energy Technology Data Exchange (ETDEWEB)

Till, C.E.; Chang, Y.I.

1993-01-01

The Integral Fast Reactor (IFR) fuel cycle holds promise for substantial improvements in economics, diversion-resistance, and waste management. This paper discusses technical features of the IFR fuel cycle, its technical progress, the development status, and the future plans and directions.

Integral Fast Reactor Program annual progress report, FY 1991

International Nuclear Information System (INIS)

1992-06-01

This report summarizes highlights of the technical progress made in the Integral Fast Reactor (IFR) Program in FY 1991. Technical accomplishments are presented in the following areas of the IFR technology development activities: (1) metal fuel performance, (2) pyroprocess development, (3) safety experiments and analyses, (4) core design development, (5) fuel cycle demonstration, and (6) LMR technology R ampersand D

Integral Fast Reactor Program. Annual progress report, FY 1993

Energy Technology Data Exchange (ETDEWEB)

Chang, Y.I.; Walters, L.C.; Laidler, J.J.; Pedersen, D.R.; Wade, D.C.; Lineberry, M.J.

1994-10-01

This report summarizes highlights of the technical progress made in the Integral Fast Reactor (IFR) Program in FY 1993. Technical accomplishments are presented in the following areas of the IFR technology development activities: (1) metal fuel performance, (2) pyroprocess development, (3) safety experiments and analyses, (4) core design development, (5) fuel cycle demonstration, and (6) LMR technology R and D.

Integral Fast Reactor Program. Annual progress report, FY 1993

International Nuclear Information System (INIS)

Chang, Y.I.; Walters, L.C.; Laidler, J.J.; Pedersen, D.R.; Wade, D.C.; Lineberry, M.J.

1994-10-01

This report summarizes highlights of the technical progress made in the Integral Fast Reactor (IFR) Program in FY 1993. Technical accomplishments are presented in the following areas of the IFR technology development activities: (1) metal fuel performance, (2) pyroprocess development, (3) safety experiments and analyses, (4) core design development, (5) fuel cycle demonstration, and (6) LMR technology R and D

FROM PERSONALIZED TO PRECISION MEDICINE

Directory of Open Access Journals (Sweden)

K. V. Raskina

2017-01-01

Full Text Available The need to maintain a high quality of life against a backdrop of its inevitably increasing duration is one of the main problems of modern health care. The concept of "right drug to the right patient at the right time", which at first was bearing the name "personalized", is currently unanimously approved by international scientific community as "precision medicine". Precision medicine takes all the individual characteristics into account: genes diversity, environment, lifestyles, and even bacterial microflora and also involves the use of the latest technological developments, which serves to ensure that each patient gets assistance fitting his state best. In the United States, Canada and France national precision medicine programs have already been submitted and implemented. The aim of this review is to describe the dynamic integration of precision medicine methods into routine medical practice and life of modern society. The new paradigm prospects description are complemented by figures, proving the already achieved success in the application of precise methods for example, the targeted therapy of cancer. All in all, the presence of real-life examples, proving the regularity of transition to a new paradigm, and a wide range  of technical and diagnostic capabilities available and constantly evolving make the all-round transition to precision medicine almost inevitable.

[Quo vadis, modern intensive care medicine? Outdated considerations regarding risks and side effects].

Science.gov (United States)

Duttge, G

2016-04-01

Modern intensive care medicine is faced with large challenges which are not solely caused by medical-technical progress, but above all by the demographic and value-related changes of society and its citizens. Thereby, three central problem areas are of particular interest: the fragile effectiveness of a patient's right to self-determination at the end of life, the uncertainties regarding the demarcation of futility, and the question of the influence of economic considerations (rationing) in view of the different levels for the allocation of duties and execution of duties. This article contains the revised version of the lecture from June 18, 2015 on the occasion of the 47th annual joint conference of DGIIN (Deutschen Gesellschaft für Internistische Intensivmedizin und Notfallmedizin) and ÖGIAIN (Österreichischen Gesellschaft für Internistische und Allgemeine Intensivmedizin und Notfallmedizin) on the general subject: "quality and humanity".

Quality Management Audits in Nuclear Medicine Practices. 2. Ed

International Nuclear Information System (INIS)

2015-01-01

Quality management systems are essential and should be maintained with the intent to continuously improve effectiveness and efficiency, enabling nuclear medicine to achieve the expectations of its quality policy, satisfy its customers and improve professionalism. The quality management (QM) audit methodology in nuclear medicine practice, introduced in this publication, is designed to be applied to a variety of economic circumstances. A key outcome is a culture of reviewing all processes of the clinical service for continuous improvement in nuclear medicine practice. Regular quality audits and assessments are vital for modern nuclear medicine services. More importantly, the entire QM and audit process has to be systematic, patient oriented and outcome based. The management of services should also take into account the diversity of nuclear medicine services around the world and multidisciplinary contributions. The latter include clinical, technical, radiopharmaceutical, medical physics and radiation safety procedures

International Telemedicine/Disaster Medicine Conference: Papers and Presentations

Science.gov (United States)

1991-01-01

The first International Telemedicine/Disaster Medicine Conference was held in Dec. 1991. The overall purpose was to convene an international, multidisciplinary gathering of experts to discuss the emerging field of telemedicine and assess its future directions; principally the application of space technology to disaster response and management, but also to clinical medicine, remote health care, public health, and other needs. This collection is intended to acquaint the reader with recent landmark efforts in telemedicine as applied to disaster management and remote health care, the technical requirements of telemedicine systems, the application of telemedicine and telehealth in the U.S. space program, and the social and humanitarian dimensions of this area of medicine.

Effective legal protection in the licensing of technical installations

International Nuclear Information System (INIS)

Froehler, L.

1987-01-01

Undeterminate concepts of law shall match the dynamism of technical progress in licensing technical installations (e.g. section 7, para. 2 no. 3 Atomic Energy Act). The administration and the courts have the duty to equalize normative deficits of regulation. Decrees and administrative provisions have an important impact. Administrative courts shall exercise legal protection more efficiently what e.g. can be possible after a shortening of stages of appeal. (CW) [de

Technical and economical availability of radioisotopes production in Brazil

International Nuclear Information System (INIS)

Lima, J.O.V.

1981-10-01

The technical and economical availability of radioisotopes production in Brazil by a low power research reactor, are done. The importance of radioisotope utilization and controled radiations, in areas such as medicine, industry and cost evaluation for the production in nuclear reactors. In the cost evaluation of a radioisotope production reactor, the studies developed by the Department of Nuclear Engineering of Universidade Federal de Minas Gerais - DEN/UFMG were used. The information analysis justify the technical and economical availability and the necessity of the radioisotopes production in Brazil. (E.G.) [pt

Sleep medicine services in Saudi Arabia: The 2013 national survey

Directory of Open Access Journals (Sweden)

Ahmed S Bahammam

2014-01-01

Conclusion: The sleep medicine services provided in the KSA have improved since the 2005 survey; however, these services are still below the level of service provided in developed countries. Organized efforts are needed to overcome the identified obstacles and challenges to the progress of sleep medicine in the KSA.

Determination of aims military-technical policy of Ukraine

Directory of Open Access Journals (Sweden)

O. F. Salnikova

2014-06-01

Full Text Available In the article the aims of military-technical policy are considered. Determination of aims (tasks of military-technical policy, its maintenance, requirements to it and directions of its further development it must come true by the analysis of different factors of external and internal environment. Among such factors: geopolitical and military-political position of Ukraine and its military doctrine; realized and operating programs of development (reformation of the soldiery forming and them technical rigging; terms of future military operations and progress of their maintenance, forms, methods and characteristic signs of battle actions trend; substantive provisions of art of war; conceptions, theories and doctrines of battle application of the soldiery forming of the different states; resources dedicated by the state on development of military-technical sphere and others like that. The fundamental chart of sequence of forming of public military-technical policy is presented in the article.

Humic substances in performance assessment of nuclear waste disposal: Actinide and iodine migration in the far-field. First technical progress report

International Nuclear Information System (INIS)

Buckau, G.

2003-04-01

The present project is one in a series of research activities supported by the European Commission on the role of humic substances for the long-term safety of nuclear waste disposal. These activities started in the mid eighties within the MIRAGE project (MIgration of RAdionuclides in the GEosphere) with the most recent project being ''Effects of humic substances on the migration of radionuclides: Complexation and transport of actinides (HUMICS)'' (FI4W-CT96-0028). The HUMICS project was conducted within the fourths framework of the European Commissions research program. It started January 1997 and had a duration of three years. The results of the HUMICS project can be found in three open technical progress reports and a final report [1-4]. In analogy with the HUMICS project, the present project makes use of annual technical progress reports where individual results are published as papers in the form of annexes. By this approach, results rapidly become available to interested parties in a compact form before their publication in various scientific journals and conference proceedings. Furthermore, some of the more preliminary and/or detailed results are not likely to appear in scientific journals and proceedings. The present project is conducted within the fifths framework of the European Commissions research program. It started November 2001 and has a duration of three years. The present report covers the first project year, i.e. November 2001 to September 2002. The project is divided into eight different work packages. These are (i) ''Critical assessment of experimental methods'', (ii) ''Generation and characterization of humic substances'', (iii) ''Radionuclide humate interaction data by designed system investigations'', (iv) ''Characterization of radionuclide humate complexes'', (v) ''Natural chemical analogue studies'', (vi) ''Radionuclide transport experiments'', (vii) ''Model development'', and (viii) ''Performance assessment''. Division of work into

The pharmacology of regenerative medicine.

Science.gov (United States)

Christ, George J; Saul, Justin M; Furth, Mark E; Andersson, Karl-Erik

2013-07-01

Regenerative medicine is a rapidly evolving multidisciplinary, translational research enterprise whose explicit purpose is to advance technologies for the repair and replacement of damaged cells, tissues, and organs. Scientific progress in the field has been steady and expectations for its robust clinical application continue to rise. The major thesis of this review is that the pharmacological sciences will contribute critically to the accelerated translational progress and clinical utility of regenerative medicine technologies. In 2007, we coined the phrase "regenerative pharmacology" to describe the enormous possibilities that could occur at the interface between pharmacology, regenerative medicine, and tissue engineering. The operational definition of regenerative pharmacology is "the application of pharmacological sciences to accelerate, optimize, and characterize (either in vitro or in vivo) the development, maturation, and function of bioengineered and regenerating tissues." As such, regenerative pharmacology seeks to cure disease through restoration of tissue/organ function. This strategy is distinct from standard pharmacotherapy, which is often limited to the amelioration of symptoms. Our goal here is to get pharmacologists more involved in this field of research by exposing them to the tools, opportunities, challenges, and interdisciplinary expertise that will be required to ensure awareness and galvanize involvement. To this end, we illustrate ways in which the pharmacological sciences can drive future innovations in regenerative medicine and tissue engineering and thus help to revolutionize the discovery of curative therapeutics. Hopefully, the broad foundational knowledge provided herein will spark sustained conversations among experts in diverse fields of scientific research to the benefit of all.

Technical errors in planar bone scanning.

Science.gov (United States)

Naddaf, Sleiman Y; Collier, B David; Elgazzar, Abdelhamid H; Khalil, Magdy M

2004-09-01

Optimal technique for planar bone scanning improves image quality, which in turn improves diagnostic efficacy. Because planar bone scanning is one of the most frequently performed nuclear medicine examinations, maintaining high standards for this examination is a daily concern for most nuclear medicine departments. Although some problems such as patient motion are frequently encountered, the degraded images produced by many other deviations from optimal technique are rarely seen in clinical practice and therefore may be difficult to recognize. The objectives of this article are to list optimal techniques for 3-phase and whole-body bone scanning, to describe and illustrate a selection of deviations from these optimal techniques for planar bone scanning, and to explain how to minimize or avoid such technical errors.

Progress and status of the Integral Fast Reactor (IFR) fuel cycle development

International Nuclear Information System (INIS)

Till, C.E.; Chang, Y.I.

1991-01-01

The Integral Fast Reactor (IFR) fuel cycle holds promise for substantial improvements in economics, diversion-resistance, and waste management. This paper discusses technical features of the IFR fuel cycle, its technical progress, the development status, and the future plans and directions. 10 refs

Progress and status of the Integral Fast Reactor (IFR) fuel cycle development

Energy Technology Data Exchange (ETDEWEB)

Till, C.E.; Chang, Y.I.

1991-01-01

The Integral Fast Reactor (IFR) fuel cycle holds promise for substantial improvements in economics, diversion-resistance, and waste management. This paper discusses technical features of the IFR fuel cycle, its technical progress, the development status, and the future plans and directions. 10 refs.

Progress and status of the Integral Fast Reactor (IFR) fuel cycle development

International Nuclear Information System (INIS)

Till, C.E.; Chang, Y.I.

1991-01-01

The Integral Fast Reactor (IFR) fuel cycle holds promise for substantial improvements in economics, diversion-resistance, and waste management. This paper discusses technical features of the IFR fuel cycle, its technical progress, the development status, and the future plans and directions. (author)

Evaluation of Herbal Medicines: Value Addition to Traditional Medicines Through Metabolism, Pharmacokinetic and Safety Studies.

Science.gov (United States)

Thelingwani, Roslyn; Masimirembwa, Collen

2014-01-01

The safety and efficacy of herbal medicines remain major issues of concern especially in the developing world where the use is high. The World Health Organisation estimates up to 80% of the population in Africa relies on herbal medicines for treatment of many diseases. Minimum safety evaluations need to be done for both the herbal and conventional drugs, in particular when there is a high likelihood of co-administration. This is particularly important in Africa where there is increased access to antiretrovirals in the treatment of HIV/AIDS, which are being used in a population background characterized by rampant use of herbal medicines. Many techniques used in the discovery and evaluation of conventional drugs can be adapted to herbal medicines. Such evaluations will add value to herbal medicines as doctors and patients will be better informed on which drugs and herbal medicines to take or not take together. This can also lead to the adoption of guidelines by regulatory agents such as the European Medicines Agency (EMA), Food and Drug Administration (FDA) and governmental agencies controlling the use of medicines. Of current interest is the evaluation of drug-herb interactions (DHI) involving the absorption, distribution, metabolism and excretion (ADME) of medicines where there is a promising possibility to adopt the current FDA and EMA guidelines on the evaluation of herbal medicines for drug-drug interactions (DDI). In this review we demonstrate progress made so far in DHI and point to possible future developments that will contribute to the safe use of herbal medicines.

GT-MHR COMMERCIALIZATION STUDY TECHNICAL PROGRESS AND COST MANAGEMENT REPORT FOR THE PERIOD AUGUST 1 THROUGH AUGUST 31, 2003

International Nuclear Information System (INIS)

Shenoy, A.S.

2003-01-01

OAK A271 GT-MHR COMERCIALiZATION STUDY TECHNICAL PROGRESS AND COST MANAGEMENT REPORT FOR THE PERIOD AUGUST 1 THROUGH AUGUST 31, 2003. In the process of fabricating the MHR-1 irradiation test capsule, Petten has advised that three thermocouples (out of 24) and the Self Powered Neutron detector were damaged during high temperature brazing with the upper capsule lid. Procurement of new TCs and SPN is in process but there will be a delay in the irradiation test of about nine weeks. Startup of the irradiation is now projected to be July or August 2004. In preparation for performing the nuclear design analysis activities required by the advanced fuel studies task, a complete 3-D nuclear design analysis is first being performed of the GT-MHR reference design. This will serve as the baseline for studies of the advanced fuel nuclear design performance

Fundamental studies of separation processes. Technical progress report

International Nuclear Information System (INIS)

Rogers, L.B.

1975-06-01

Studies using high-precision gas chromatography and supercritical fluid chromatography have produced new types of information on liquid crystals and on behavior of substances in the region of the critical temperature, respectively. In addition, the first successful studies of the effects of pressure on cation exchange have been made using aqueous solutions of alkali metal nitrates. In contrast, progress on separations of isotopic species using gas chromatography has been disappointing. In that area, the chief accomplishment has been a determination of the levels of accuracy and precision with which isotopic abundances can be measured using our quadrupole mass spectrometer. (U.S.)

The Michigan high-level radioactive waste program: Final technical progress report

International Nuclear Information System (INIS)

1987-01-01

This report comprises the state of Michigan's final technical report on the location of a proposed high-level radioactive waste disposal site. Included are a list of Michigan's efforts to review the DOE proposal and a detailed report on the application of geographic information systems analysis techniques to the review process

The Medicinal Chemistry of Therapeutic Oligonucleotides.

Science.gov (United States)

Wan, W Brad; Seth, Punit P

2016-11-10

Oligonucleotide-based therapeutics have made rapid progress in the clinic for treatment of a variety of disease indications. Unmodified oligonucleotides are polyanionic macromolecules with poor drug-like properties. Over the past two decades, medicinal chemists have identified a number of chemical modification and conjugation strategies which can improve the nuclease stability, RNA-binding affinity, and pharmacokinetic properties of oligonucleotides for therapeutic applications. In this perspective, we present a summary of the most commonly used nucleobase, sugar and backbone modification, and conjugation strategies used in oligonucleotide medicinal chemistry.

Site characterization progress report: Yucca Mountain, Nevada. Progress report number 17, April 1, 1997--September 30, 1997

Energy Technology Data Exchange (ETDEWEB)

NONE

1998-04-01

The US Department of Energy`s (DOE) Office of Civilian Radioactive Waste Management (OCRWM), created with the enactment of the Nuclear Waste Policy Act of 1982 (NWPA), is tasked to accept and dispose of the nation`s high-level radioactive waste and spent nuclear fuel in a deep geologic repository (high-level radioactive waste program). The report summarizes significant site characterization activities during the period from April 1, 1997 through September 30, 1997, in the evaluation of Yucca Mountain as a potential site for the geologic disposal of spent nuclear fuel and high-level radioactive wastes. The progress report also cites technical reports and research products that provide the detailed information on these activities. Chapter 2 outlines technical and regulatory issues that must be addressed by the Project and planned work toward achieving future objectives concerning the viability assessment, the environmental impact statement, the site recommendation, and the license application. Chapter 3 describes technical progress in preclosure radiological safety analysis, postclosure performance assessment, and performance confirmation activities. Chapter 4 describes various aspects of repository and waste package design and construction. It also discusses the Exploration Studies Facility cross drift. Chapter 5 describes site characterization activities, and Chapter 6 contains a complete list of references.

Site characterization progress report: Yucca Mountain, Nevada. Progress report number 17, April 1, 1997 - September 30, 1997

International Nuclear Information System (INIS)

1998-04-01

The US Department of Energy's (DOE) Office of Civilian Radioactive Waste Management (OCRWM), created with the enactment of the Nuclear Waste Policy Act of 1982 (NWPA), is tasked to accept and dispose of the nation's high-level radioactive waste and spent nuclear fuel in a deep geologic repository (high-level radioactive waste program). The report summarizes significant site characterization activities during the period from April 1, 1997 through September 30, 1997, in the evaluation of Yucca Mountain as a potential site for the geologic disposal of spent nuclear fuel and high-level radioactive wastes. The progress report also cites technical reports and research products that provide the detailed information on these activities. Chapter 2 outlines technical and regulatory issues that must be addressed by the Project and planned work toward achieving future objectives concerning the viability assessment, the environmental impact statement, the site recommendation, and the license application. Chapter 3 describes technical progress in preclosure radiological safety analysis, postclosure performance assessment, and performance confirmation activities. Chapter 4 describes various aspects of repository and waste package design and construction. It also discusses the Exploration Studies Facility cross drift. Chapter 5 describes site characterization activities, and Chapter 6 contains a complete list of references

Significance of technical rules for environmental pollution control

International Nuclear Information System (INIS)

Grefen, K.

1989-01-01

Technical rules for environmental pollution control are very important in times of intensified technical progress and especially in view of the alterations of the legislative basis of the European Market in 1992. In the fields of jurisprudence, science and technology they serve as a decision-making aid for authorities, specialists in plant development and operation and the preparatory stages of international legislation. The topic is explained by the development of guidelines with the VDI-Commission on Air Pollution Prevention. (orig.) [de

TECHNICAL COORDINATION

CERN Multimedia

Austin Ball

Summary of progress since last CMS week. Ten years of construction work have been completed. CMS is closed, in very close to the ideal low luminosity configuration, and performed well in the first tests with LHC beam. Behind this encouraging news is the story of a summer of intense commitment by many teams (from the collaboration and 3 CERN departments) working together, against the clock and despite many minor setbacks, to ensure that the experiment was ready to play a leading role in the excitement of September 10. Following beampipe bakeout and refill with pure neon, a magnificent effort by the ECAL group and the pt 5 technical crew made it possible to install and commission all 4 ECAL endcap Dees before the end of August. In the shadow of this activity, the barrel and forward pixel trackers and part of the beam monitoring were installed within the vac tank. The pt 5 technical teams then succeeded in safely removing the 20t installation tables and their support blocks from beneath the already installed ...

Activity Progress report 1982-1985

International Nuclear Information System (INIS)

1986-01-01

This reports gives a summary of all activities of the Elementary Particle Physics Department at Saclay between the beginning of 1982 and the end of 1985. The experiments in progress or in preparation are presented by subject. The main technical studies and achievements are also described. Finally lists of publications and information concerning Department organization are given [fr

Advancing Simulation-Based Education in Pain Medicine.

Science.gov (United States)

Singh, Naileshni; Nielsen, Alison A; Copenhaver, David J; Sheth, Samir J; Li, Chin-Shang; Fishman, Scott M

2018-02-27

The Accreditation Council for Graduate Medical Education (ACGME) has recently implemented milestones and competencies as a framework for training fellows in Pain Medicine, but individual programs are left to create educational platforms and assessment tools that meet ACGME standards. In this article, we discuss the concept of milestone-based competencies and the inherent challenges for implementation in pain medicine. We consider simulation-based education (SBE) as a potential tool for the field to meet ACGME goals through advancing novel learning opportunities, engaging in clinically relevant scenarios, and mastering technical and nontechnical skills. The sparse literature on SBE in pain medicine is highlighted, and we describe our pilot experience, which exemplifies a nascent effort that encountered early difficulties in implementing and refining an SBE program. The many complexities in offering a sophisticated simulated pain curriculum that is valid, reliable, feasible, and acceptable to learners and teachers may only be overcome with coordinated and collaborative efforts among pain medicine training programs and governing institutions.

Radiosanitary control in nuclear medicine

International Nuclear Information System (INIS)

Degrossi, O.J.

1987-01-01

Nuclear Medicine has recently modified radiosanitary control standards for the three sectors involved: patients, personnel and general population. Nuclear Medicine does not constitute an important source of radiation, including patients and population, compared with radiology. The basic problems of radiosanitary controls are: the absorbed dose and the patient. Low risk deferred stochastic effects may appear with correct use of these controls. On the other hand, risk of stochastic consequences and non stochastic complications appear with incorrect applications. The following aspects should be considered for correct uses: A-1- The critical organ, which is not always the one under study. 2-The rest of the organism, specially the more sensitive organs. B- The radiopharmaceutical used, considering the following periods: physical, biological and effective. C-Technical and human resources that include quality control for the equipment. Radiosanitary control aims at a common objetive: dose limitation to the patient, personnel and general population. For this, it is necessary to accomplish the training programme for proffesional and technical personnel about quality control and to stablish basic standards for the equipment. Current law and regulations assign to the National Atomic Energy Comission the responsibility for controlling the use of radioisotopes and radiations in order to safeguard the health and life of the population. (M.E.L.) [es

Aerospace Medicine and Biology. A continuing bibliography with indexes

Science.gov (United States)

1982-01-01

This bibliography lists 244 reports, articles, and other documents introduced into the NASA scientific and technical information system in February 1981. Aerospace medicine and aerobiology topics are included. Listings for physiological factors, astronaut performance, control theory, artificial intelligence, and cybernetics are included.

Aerospace medicine and biology. A continuing bibliography with indexes

International Nuclear Information System (INIS)

1982-03-01

This bibliography lists 244 reports, articles, and other documents introduced into the NASA scientific and technical information system in February 1981. Aerospace medicine and aerobiology topics are included. Listings for physiological factors, astronaut performance, control theory, artificial intelligence, and cybernetics are included

Treating gynaecological disorders with traditional Chinese medicine ...

African Journals Online (AJOL)

Traditional Chinese Medicine (TCM) has significant advantages in treating gynaecological disorders. The paper has provided a brief introduction on the current progress of treating some gynaecological disorders including endometriosis, infertility, dysmenorrhea, abnormal uterine bleeding, premenstrual syndrome, ...

[Current status and prospect of translational medicine in nanotechnology].

Science.gov (United States)

Gao, Guang-yu; Chen, Mei-ling; Li, Ming-yuan; Yang, Zhen-bo; Li, Zhi-ping; Mei, Xing-guo

2015-08-01

Nowadays, nanotechnologies have shown wide application foreground in the biomedical field of medicine laboratory tests, drug delivery, gene therapy and bioremediation. However, in recent years, nanomaterials have been labeled poisonous, because of the disputes and misunderstandings of mainstream views on their safety. Besides, for the barriers of technical issues in preparation like: (1) low efficacy (poor PK & PD and low drug loading), (2) high cost (irreproducibility and difficulty in scale up), little of that research has been successfully translated into commercial products. Currently, along with the new theory of "physical damage is the origin of nanotoxicity", biodegradability and biocompatibility of nanomaterials are listed as the basic principle of safe application of nanomaterials. Combining scientific design based on molecular level with precision control of process engineering will provide a new strategy to overcome the core technical challenges. New turning point of translational medicine in nanotechnology may emerge.

Influence of comorbidities on therapeutic progression of diabetes treatment in Australian veterans: a cohort study.

Directory of Open Access Journals (Sweden)

Agnes I Vitry

Full Text Available BACKGROUND: This study assessed whether the number of comorbid conditions unrelated to diabetes was associated with a delay in therapeutic progression of diabetes treatment in Australian veterans. METHODOLOGY/PRINCIPAL FINDINGS: A retrospective cohort study was undertaken using data from the Australian Department of Veterans' Affairs (DVA claims database between July 2000 and June 2008. The study included new users of metformin or sulfonylurea medicines. The outcome was the time to addition or switch to another antidiabetic treatment. The total number of comorbid conditions unrelated to diabetes was identified using the pharmaceutical-based comorbidity index, Rx-Risk-V. Competing risk regression analyses were conducted, with adjustments for a number of covariates that included age, gender, residential status, use of endocrinology service, number of hospitalisation episodes and adherence to diabetes medicines. Overall, 20,134 veterans were included in the study. At one year, 23.5% of patients with diabetes had a second medicine added or had switched to another medicine, with 41.4% progressing by 4 years. The number of unrelated comorbidities was significantly associated with the time to addition of an antidiabetic medicine or switch to insulin (subhazard ratio [SHR] 0.87 [95% CI 0.84-0.91], P<0.001. Depression, cancer, chronic obstructive pulmonary disease, dementia, and Parkinson's disease were individually associated with a decreased likelihood of therapeutic progression. Age, residential status, number of hospitalisations and adherence to anti-diabetic medicines delayed therapeutic progression. CONCLUSIONS/SIGNIFICANCE: Increasing numbers of unrelated conditions decreased the likelihood of therapeutic progression in veterans with diabetes. These results have implications for the development of quality measures, clinical guidelines and the construction of models of care for management of diabetes in elderly people with comorbidities.

A Simple extension of Dematerialization Theory: Incorporation of Technical Progress and the Rebound Effect

OpenAIRE

Magee, Christopher L.; Devezas, Tessaleno C.

2016-01-01

Dematerialization is the reduction in the quantity of materials needed to produce something useful over time. Dematerialization fundamentally derives from ongoing increases in technical performance but it can be counteracted by demand rebound - increases in usage because of increased value (or decreased cost) that also results from increasing technical performance. A major question then is to what extent technological performance improvement can offset and is offsetting continuously increasin...

Electronic refrigerant leak detector. Quarterly technical progress report

Energy Technology Data Exchange (ETDEWEB)

Talamas, E. Jr.

1998-10-15

The project comprises three main tasks. They are (1) Develop, design, and fabricate sensors, (2) Develop, design, and fabricate test instruments, (3) Testing and data analysis. The milestone includes 17 sub-tasks for the 52-weeks project period, starting on May 1, 1998 and ending on April 30, 1999. As stated in the Application for Federal Assistance, Micronic intended to relocate to a new office by June of 1998. This decision was delayed, since the first partial payment was transferred on August 12, 1998. Micronic plans to relocate this November. A second Provisional Application for a US patent has been filed. Progress made during this period is reported.

Retrospective analysis of anthropometric and fitness characteristics associated with long-term career progression in Rugby League.

Science.gov (United States)

Till, Kevin; Cobley, Steve; O'Hara, John; Morley, David; Chapman, Chris; Cooke, Carlton

2015-05-01

The current study retrospectively investigated the differences in anthropometric and fitness characteristics of junior rugby league players selected onto a talent identification and development (TID) programme between long-term career progression levels (i.e., amateur, academy, professional). Retrospective design. Former junior rugby league players (N=580) selected to a TID programme were grouped according to their career progression level. Anthropometric (height, sitting height, body mass and sum of four skinfolds), maturational and fitness (power, speed, change of direction speed and estimated V̇O2max) assessments were conducted at 13-15 years. Multivariate analysis of covariance (MANCOVA) analyzed differences between career progression levels controlling for chronological age. 57.1% and 12.1% of players selected to the TID programme progressed to academy and professional levels in rugby league, respectively. Sum of four skinfolds (η(2)=0.03), vertical jump (η(2)=0.02), 10 m (η(2)=0.02), 20 m (η(2)=0.02), 30 m (η(2)=0.02), and 60 m (η(2)=0.03) speed, agility 505 left (η(2)=0.06), agility 505 right (η(2)=0.05) and estimated V̇O2max (η(2)=0.03) were superior within junior players who progressed to professional compared to amateur levels. No significant differences were identified between future academy and professional players for any measure. Findings suggest that lower sum of four skinfolds and advanced fitness characteristics within junior (13-15 years) rugby league players may partially contribute to long-term career progression. Therefore, TID programmes within rugby league should aim to assess and develop body composition and fitness characteristics, especially change of direction speed. However, TID programmes should also consider technical, tactical and psycho-social characteristics of junior rugby league players that may be important for long-term career progression. Copyright © 2014 Sports Medicine Australia. Published by Elsevier Ltd. All

Progress in the domain of emissions tracking and environment radioactivity monitoring - Proceedings of the technical days organised by the SFRP Environment Section

International Nuclear Information System (INIS)

Calmet, Dominique; Calvez, Marianne; Rivasseau, Corinne Cea; Monfort, Marguerite; Manificat, Guillaume; Pierrard, Olivier; Couvez, Celine; Masson, Olivier; Bruno, Valerie; Renaud, Philippe; Genova, Zhana; Reynal, Nathalie; Le Coz, Eric; Tchilian, Nathalie; Diana, Jean-Jacques; Beguinel, Philippe; Cortes, Pierre; Puydarrieux, Stephane; Brun, Thierry; Devin, Patrick; Clavel, Benoit; Hemidy, Pierre-Yves; Gontier, Gilles; Delloye, Thierry; Mailliat, Alain; Ferreri, Giovanni; LECLERC, Elisabeth

2015-11-01

The Environment Section of the French Society of Radiation Protection (SFRP) organized a technical meeting on the progress made in the domain of emissions tracking and environment radioactivity monitoring. This document brings together the abstracts and the presentations (slides) of the different talks given at the meeting: 1 - Environment monitoring at the global, national and local scale: historical overview (Dominique CALMET, CEA); 2 - Evolution of radioactivity monitoring in the environment from 1960 to the present day (Guillaume MANIFICAT, IRSN); 3 - Euratom's legal framework (Zhana GENOVA, CTE); 4 - Main regulatory changes during the last decade (Nathalie REYNAL, ASN); 5 - Progress of standardization works on radioactive effluent emissions control and environment monitoring (Philippe BEGUINEL, BNEN); 6 - From operators' self-monitoring to ASN's inspections: a many components control system (Eric LE COZ, ASN); 7 - Control of effluents and emissions management at CEA Centres (Marianne CALVEZ, CEA); 8 - Liquid and gaseous effluents of ITER experimental facility: description and impacts (Pierre CORTES, IO); 9 - Effluents and emissions management strategy at AREVA NC La Hague facility (Stephane PUYDARRIEUX, AREVA); 10 - Radioactive effluents from nuclear facilities ongoing deconstruction: from dimensioning to real effluents (Benoit CLAVEL, EDF); 11 - Radionuclides decontamination process for liquid effluents using micro-algae at the laboratory scale (Corinne RIVASSEAU, CEA); 12 - Radioactive effluents from nuclear medicine services: management, monitoring and impact measurement methods (Nathalie TCHILIAN, ASN); 13 - Evolution history of effluents management and environment monitoring at the Solvay La Rochelle site (Thierry DELLOYE, SOLVAY); 14 - Different international approaches in effluents management and monitoring: example of French and German gaseous effluents - regulation, analyses, accounting rules (Jean-Jacques DIANA, ASN); 15 - Environment

Professional Technical Standards in Colleges and Schools of Pharmacy

Science.gov (United States)

Berry, Tricia M.; Chichester, Clinton O.; Sanoski, Cynthia A.; Woodward, Donald A.; Worley, Marcia M.; Early, Johnnie L.

2011-01-01

Objective To determine the prevalence, characteristics, and use of professional technical standards among colleges and schools of pharmacy accredited by the Accreditation Council for Pharmacy Education (ACPE). Methods The Web site of every college and school of pharmacy accredited by ACPE was searched to identify information regarding the availability, content, and use of technical standards and to obtain demographic information. Results Information was obtained from all of the 114 colleges and schools of pharmacy and 67 (59%) had technical standards in place. Common themes for technical standards were: observation; communication; motor; intellectual, conceptual, integrative and quantitative abilities; and behavioral and social attributes. Of those colleges and schools with technical standards, 61 (91%) had standards that addressed all 5 of these themes and 34 (51%) specified that the technical standards were used in their admission, progression, and graduation procedures. Conclusion More than half of the colleges and schools of pharmacy examined in this study have technical standards; however, 41% have yet to develop and implement them. Colleges and schools of pharmacy looking for guidance in technical standards development could use the technical standards themes identified in this study. PMID:21655404

Efficacy of clinical diagnostic procedures utilized in nuclear medicine. Nine month progress report

Energy Technology Data Exchange (ETDEWEB)

None

1978-01-01

This study is designed to determine the efficacy of nuclear medicine procedures in clinical practice. Several methods of determining efficacy will be evaluated to determine those most suitable. Nuclear medicine methods will be confined to the study of lung diseases by pulmonary perfusion and ventilation. In addition to evaluating the above methods data will be obtained to determine the sensitivity, specificity, predictive value and efficiency of the test under consideration. These values, corrected for prevalence of the disease processes under consideration will then be compared to the values obtained by the MACRO and MICRO methods and will help to bound the clinical reliability of the diagnostic method depending on the degree to which the several methods trend together. Depending on the practicality of these two methods, in addition to the determination of efficacy, cost effectiveness factors and benefit-risk estimates which are used to apply to radiation effects will be determined for nuclear medicine studies of the brain, bone, heart, liver and thyroid subsequently. The measurement techniques will then be utilized to establish guidelines for the most useful applications of the given procedure so that clinicians will be able to obtain a pretest estimate of the utility of the nuclear medicine test.

Coal to SNG: Technical progress, modeling and system optimization through exergy analysis

International Nuclear Information System (INIS)

Li, Sheng; Ji, Xiaozhou; Zhang, Xiaosong; Gao, Lin; Jin, Hongguang

2014-01-01

Highlights: • Technical progresses of coal to SNG technologies are reported. • The entire coal to SNG system is modeled. • Coupling between SNG production and power generation is investigated. • Breakthrough points for further energy saving are determined. • System performance is optimized based on the first and second laws of thermodynamics. - Abstract: For both energy security and CO 2 emission reduction, synthetic natural gas (SNG) production from coal is an important path to implement clean coal technologies in China. In this paper, an overview of the progress of coal to SNG technologies, including the development of catalysts, reactor designs, synthesis processes, and systems integration, is provided. The coal to SNG system is modeled, the coupling between SNG production and power generation is investigated, the breakthrough points for further energy savings are determined, and the system performance is optimized based on the first and the second laws of thermodynamics. From the viewpoint of the first law of thermodynamics, the energy conversion efficiency of coal to SNG system can reach 59.8%. To reduce the plant auxiliary power, the breakthrough points are the development of low-energy-consumption oxygen production technology and gas purification technology or seeking new oxidants for coal gasification instead of oxygen. From the viewpoint of the second law of thermodynamics, the major exergy destruction in a coal to SNG system occurs in the coal gasification unit, SNG synthesis unit and the raw syngas cooling process. How to reduce the exergy destruction in these units is the key to energy savings and system performance enhancement. The conversion ratio of the first SNG synthesis reactor and the split ratio of the recycle gas are key factors that determine the performance of both the SNG synthesis process and the whole plant. A “turning point” phenomenon is observed: when the split ratio is higher than 0.90, the exergy destruction of the SNG

Power systems development facility. Quarterly technical progress report, July 1--September 30, 1993

Energy Technology Data Exchange (ETDEWEB)

1993-12-31

This quarterly technical progress report summarizes work completed during the Second Quarter of the Second Budget Period, July 1 through September 30, 1993, under the Department of Energy (DOE) Cooperative Agreement No. DE-FC21-90MC25140 entitled ``Hot Gas Cleanup Test Facility for Gasification and Pressurized Combustion.`` The objective of this project is to evaluate hot gas particle control technologies using coal-derived gas streams. This will entail the design, construction, installation, and use of a flexible test facility which can operate under realistic gasification and combustion conditions. The major particulate control device issues to be addressed include the integration of the particulate control devices into coal utilization systems, on-line cleaning techniques, chemical and thermal degradation of components, fatigue or structural failures, blinding, collection efficiency as a function of particle size, and scaleup of particulate control systems to commercial size. The conceptual design of the facility was extended to include a within scope, phased expansion of the existing Hot Gas Cleanup Test Facility Cooperative Agreement to also address systems integration issues of hot particulate removal in advanced coal-based power generation systems. This expansion included the consideration of the following modules at the test facility in addition to the existing Transport Reactor gas source and Hot Gas Cleanup Units: Carbonizer/Pressurized Circulating Fluidized Bed Gas Source. Hot Gas Cleanup Units to mate to all gas streams; Combustion Gas Turbine; and Fuel Cell and associated gas treatment. This expansion to the Hot Gas Cleanup Test Facility is herein referred to as the Power Systems Development Facility (PSDF). The major emphasis during this reporting period was continuing the detailed design of the facility.

Scientific progress as increasing verisimilitude.

Science.gov (United States)

Niiniluoto, Ilkka

2014-06-01

According to the foundationalist picture, shared by many rationalists and positivist empiricists, science makes cognitive progress by accumulating justified truths. Fallibilists, who point out that complete certainty cannot be achieved in empirical science, can still argue that even successions of false theories may progress toward the truth. This proposal was supported by Karl Popper with his notion of truthlikeness or verisimilitude. Popper's own technical definition failed, but the idea that scientific progress means increasing truthlikeness can be expressed by defining degrees of truthlikeness in terms of similarities between states of affairs. This paper defends the verisimilitude approach against Alexander Bird who argues that the "semantic" definition (in terms of truth or truthlikeness alone) is not sufficient to define progress, but the "epistemic" definition referring to justification and knowledge is more adequate. Here Bird ignores the crucial distinction between real progress and estimated progress, explicated by the difference between absolute (and usually unknown) degrees of truthlikeness and their evidence-relative expected values. Further, it is argued that Bird's idea of returning to the cumulative model of growth requires an implausible trick of transforming past false theories into true ones.

Private sector involvement in the US program of technical assistance to IAEA safeguards

International Nuclear Information System (INIS)

Pepper, S.E.; Epel, L.; Maise, G.; Reisman, A.; Skalyo, J.

1995-01-01

The US Program of Technical Assistance to IAEA Safeguards (POTAS) relies on technical expertise found in the U. S private and public sectors. Since 1993, the international Safeguards Project Office (ISPO) has sought to increase the role of the private sector in POTAS. ISPO maintains and continues to develop a database of US companies interested in providing technical expertise to the IAEA. This database is used by ISPO to find appropriate contractors to respond to IAEA requests for technical assistance when the assistance can be provided by the private sector. The private sector is currently providing support in the development of equipment, training, and procedure preparation. POTAS also supports the work of private consultants. This paper discusses ISPO's efforts to identify suitable vendors and discusses conditions that hinder more substantial involvement by the private sector. In addition, the paper will discuss selected projects that are currently in progress and identify common problems that impede the progress and success of tasks performed by the private sector

Progress of the HTR-10 project

International Nuclear Information System (INIS)

Zhong, D.; Xu, Y.

1996-01-01

This paper briefly introduces the main technical features and the design specifications of the HTR-10. Present status and main progress of the license applications, the design and manufacture of the main components and the engineering experiments as well as the construction of the HTR-10 are summarized. (author). 3 tabs

Tanks Focus Area FY98 midyear technical review

Energy Technology Data Exchange (ETDEWEB)

Schlahta, S.N.; Brouns, T.M.

1998-06-01

The Tanks Focus Area (TFA) serves as the DOE`s Office of Environmental Management`s national technology and solution development program for radioactive waste tank remediation. Its technical scope covers the major functions that comprise a complete tank remediation system: waste retrieval, waste pretreatment, waste immobilization, tank closure, and characterization of both the waste and tank with safety integrated into all the functions. In total, 17 technologies and technical solutions were selected for review. The purpose of each review was to understand the state of development of each technology selected for review and to identify issues to be resolved before the technology or technical solution progressed to the next level of maturity. The reviewers provided detailed technical and programmatic recommendations and comments. The disposition of these recommendations and comments and their impact on the program is documented in this report.

Tanks Focus Area FY98 midyear technical review

International Nuclear Information System (INIS)

Schlahta, S.N.; Brouns, T.M.

1998-06-01

The Tanks Focus Area (TFA) serves as the DOE's Office of Environmental Management's national technology and solution development program for radioactive waste tank remediation. Its technical scope covers the major functions that comprise a complete tank remediation system: waste retrieval, waste pretreatment, waste immobilization, tank closure, and characterization of both the waste and tank with safety integrated into all the functions. In total, 17 technologies and technical solutions were selected for review. The purpose of each review was to understand the state of development of each technology selected for review and to identify issues to be resolved before the technology or technical solution progressed to the next level of maturity. The reviewers provided detailed technical and programmatic recommendations and comments. The disposition of these recommendations and comments and their impact on the program is documented in this report

The role of general nuclear medicine in breast cancer

International Nuclear Information System (INIS)

Greene, Lacey R; Wilkinson, Deborah

2015-01-01

The rising incidence of breast cancer worldwide has prompted many improvements to current care. Routine nuclear medicine is a major contributor to a full gamut of clinical studies such as early lesion detection and stratification; guiding, monitoring, and predicting response to therapy; and monitoring progression, recurrence or metastases. Developments in instrumentation such as the high-resolution dedicated breast device coupled with the diagnostic versatility of conventional cameras have reinserted nuclear medicine as a valuable tool in the broader clinical setting. This review outlines the role of general nuclear medicine, concluding that targeted radiopharmaceuticals and versatile instrumentation position nuclear medicine as a powerful modality for patients with breast cancer

Chemistry of gaseous lower-valent actinide halides. Technical progress report

International Nuclear Information System (INIS)

Hildenbrand, D.L.

1984-01-01

Objective is to provide thermochemical data for key actinide halide and oxyhalide systems. Progress is reported on bond dissociation energies of gaseous ThCl 4 , ThCl 3 , ThCl 2 , and ThCl; bond dissociation energies of ruthenium fluorides; and mass spectroscopy of UF 6

Reconciling evidence-based medicine and precision medicine in the era of big data: challenges and opportunities.

Science.gov (United States)

Beckmann, Jacques S; Lew, Daniel

2016-12-19

This era of groundbreaking scientific developments in high-resolution, high-throughput technologies is allowing the cost-effective collection and analysis of huge, disparate datasets on individual health. Proper data mining and translation of the vast datasets into clinically actionable knowledge will require the application of clinical bioinformatics. These developments have triggered multiple national initiatives in precision medicine-a data-driven approach centering on the individual. However, clinical implementation of precision medicine poses numerous challenges. Foremost, precision medicine needs to be contrasted with the powerful and widely used practice of evidence-based medicine, which is informed by meta-analyses or group-centered studies from which mean recommendations are derived. This "one size fits all" approach can provide inadequate solutions for outliers. Such outliers, which are far from an oddity as all of us fall into this category for some traits, can be better managed using precision medicine. Here, we argue that it is necessary and possible to bridge between precision medicine and evidence-based medicine. This will require worldwide and responsible data sharing, as well as regularly updated training programs. We also discuss the challenges and opportunities for achieving clinical utility in precision medicine. We project that, through collection, analyses and sharing of standardized medically relevant data globally, evidence-based precision medicine will shift progressively from therapy to prevention, thus leading eventually to improved, clinician-to-patient communication, citizen-centered healthcare and sustained well-being.

[Quality assurance systems and occupational medicine system: an history twenty years along].

Science.gov (United States)

Apostoli, Pietro

2014-01-01

Along the last tventy years, in our country the quality assurance systems and the occupational medicine deeply interacted both in theoretical and practical fields of interest at three levels: (i) the need of preventive and therefore of occupational medicine in quality assurance systems; (ii) the need on reverse of quality in prevention and occupational mnedicine mainly in qualification and updating process; (iii) the evidence, proofs of efficacy or appropriateness of different preventive procedures and occupational physician activities; (iv) the connection with European and national legal directives and with technical or good practice norms. Finally we discuss about the role of occupational physician as the global consultant for enterprise, as a mandatory strategic technical figure in a typical multidisciplinary processes as the implementation of the quality systems.

Intensive care medicine trainees' perception of professionalism: a qualitative study.

NARCIS (Netherlands)

Mook, W.N. van; Grave, W.S. De; Gorter, S.L.; Zwaveling, J.H.; Schuwirth, L.W.; Vleuten, C.P.M. van der

2011-01-01

The Competency-Based Training program in Intensive Care Medicine in Europe identified 12 competency domains. Professionalism was given a prominence equal to technical ability. However, little information pertaining to fellows' views on professionalism is available. A nationwide qualitative study was

Jet Joint Undertaking. Progress report 1990

International Nuclear Information System (INIS)

1991-03-01

This JET Progress Reports provides an overview summary and puts into context the scientific and technical advances made on JET during 1990. In addition, the Report is supplemented by appendices of contributions (in preprint form) of the more important JET articles published during the year, which set out the details of JET activities

Geothermal Progress Monitor Report No. 2, January/February 1980

Energy Technology Data Exchange (ETDEWEB)

1980-01-01

Progress is reviewed in the following aspects of the program: electrical uses; direct-heat uses; leases; outreach and technical assistance; general activities; legal, institutional, and regulatory activities; and reports and publications. (MHR)

Technical and tactical soccer players' performance in conceptual small-sided games

Directory of Open Access Journals (Sweden)

Cristian Javier Ramirez Lizana

2015-09-01

Full Text Available AbstractConceptual small-sided games (CSSGs may be interesting as a methodology for training soccer players given its connection to the unpredictability that is inherent to soccer. Our aim was investigate, through videogrammetry, if the technical and tactical principles promoted through the adoption of distinct rules from two distinct CSSGs (maintaining ball possession; and progression to the target would actually be achieved. The study included 24 athletes assigned to 6-player teams. Our data showed that the CSSGs' organising principles create situations with differing levels of difficulty that obey the propositions of maintaining ball possession and progression to the target, i.e., CSSGs permit systematic training on technical and tactical components in order to emphasize the concepts adopted in this study in games context. Our data credit the CSSGs for teaching technical and tactical lessons that, when coupled with adequate physical conditioning, can facilitate a player's capacity to merge thoughts and events in different situations.

Human genomics projects and precision medicine.

Science.gov (United States)

Carrasco-Ramiro, F; Peiró-Pastor, R; Aguado, B

2017-09-01

The completion of the Human Genome Project (HGP) in 2001 opened the floodgates to a deeper understanding of medicine. There are dozens of HGP-like projects which involve from a few tens to several million genomes currently in progress, which vary from having specialized goals or a more general approach. However, data generation, storage, management and analysis in public and private cloud computing platforms have raised concerns about privacy and security. The knowledge gained from further research has changed the field of genomics and is now slowly permeating into clinical medicine. The new precision (personalized) medicine, where genome sequencing and data analysis are essential components, allows tailored diagnosis and treatment according to the information from the patient's own genome and specific environmental factors. P4 (predictive, preventive, personalized and participatory) medicine is introducing new concepts, challenges and opportunities. This review summarizes current sequencing technologies, concentrates on ongoing human genomics projects, and provides some examples in which precision medicine has already demonstrated clinical impact in diagnosis and/or treatment.

Why Physics in Medicine?

Science.gov (United States)

Samei, Ehsan; Grist, Thomas M

2018-05-18

Despite its crucial role in the development of new medical imaging technologies, in clinical practice, physics has primarily been involved in the technical evaluation of technologies. However, this narrow role is no longer adequate. New trajectories in medicine call for a stronger role for physics in the clinic. The movement toward evidence-based, quantitative, and value-based medicine requires physicists to play a more integral role in delivering innovative precision care through the intentional clinical application of physical sciences. There are three aspects of this clinical role: technology assessment based on metrics as they relate to expected clinical performance, optimized use of technologies for patient-centered clinical outcomes, and retrospective analysis of imaging operations to ensure attainment of expectations in terms of quality and variability. These tasks fuel the drive toward high-quality, consistent practice of medical imaging that is patient centered, evidence based, and safe. While this particular article focuses on imaging, this trajectory and paradigm is equally applicable to the multitudes of the applications of physics in medicine. Copyright © 2018 American College of Radiology. Published by Elsevier Inc. All rights reserved.

Quarterly technical progress report, February 1, 1996--April 30, 1996

Energy Technology Data Exchange (ETDEWEB)

NONE

1996-05-28

This report from the Amarillo National REsource Center for PLutonium provides research highlights and provides information regarding the public dissemination of information. The center is a a scientific resource for information regarding the issues of the storage, disposition, potential utilization and transport of plutonium, high explosives, and other hazardous materials generated from nuclear weapons dismantlement. The center responds to informational needs and interpretation of technical and scientific data raised by interested parties and advisory groups. Also, research efforts are carried out on remedial action programs and biological/agricultural studies.

Technical aspects of high converter reactors

International Nuclear Information System (INIS)

1992-02-01

The meeting provided an opportunity to review and discuss national R and D programs, various technical aspects of and worldwide progress in the implementation of high conversion reactors. The meeting was attended by 66 participants from 18 countries and 2 international organizations. 33 papers were presented. A separate abstract was prepared for each of these papers. Refs, figs, tabs, slides and diagram

Progress in the medicinal chemistry of silicon: C/Si exchange and beyond.

Science.gov (United States)

Fujii, Shinya; Hashimoto, Yuichi

2017-04-01

Application of silyl functionalities is one of the most promising strategies among various 'elements chemistry' approaches for the development of novel and distinctive drug candidates. Replacement of one or more carbon atoms of various biologically active compounds with silicon (so-called sila-substitution) has been intensively studied for decades, and is often effective for alteration of activity profile and improvement of metabolic profile. In addition to simple C/Si exchange, several novel approaches for utilizing silicon in medicinal chemistry have been suggested in recent years, focusing on the intrinsic differences between silicon and carbon. Sila-substitution offers great potential for enlarging the chemical space of medicinal chemistry, and provides many options for structural development of drug candidates.

[Precision medicine: new opportunities and challenges for molecular epidemiology].

Science.gov (United States)

Song, Jing; Hu, Yonghua

2016-04-01

Since the completion of the Human Genome Project in 2003 and the announcement of the Precision Medicine Initiative by U.S. President Barack Obama in January 2015, human beings have initially completed the " three steps" of " genomics to biology, genomics to health as well as genomics to society". As a new inter-discipline, the emergence and development of precision medicine have relied on the support and promotion from biological science, basic medicine, clinical medicine, epidemiology, statistics, sociology and information science, etc. Meanwhile, molecular epidemiology is considered to be the core power to promote precision medical as a cross discipline of epidemiology and molecular biology. This article is based on the characteristics and research progress of medicine and molecular epidemiology respectively, focusing on the contribution and significance of molecular epidemiology to precision medicine, and exploring the possible opportunities and challenges in the future.

Filling the gap between traditional Chinese medicine and modern medicine, are we heading to the right direction?

Science.gov (United States)

Chen, Xiuping; Pei, Lixia; Lu, Jinjian

2013-06-01

Traditional Chinese medicine (TCM), the ancient medicine popular in China and surrounding areas, has been recognized as a typical representative of complementary and alternative medicine. Over long period in clinical practice, especially the progress in basic research, data on the effectiveness and beneficial contribution of TCM herbs to public health and disease control have been accumulated while the quality of the evidence is generally poor. The most common clinical practice of TCM herbs is herb combination called formula which consists of several types of medicinal herbs or minerals, which is quite different from modern medicine. Definitely, tens of hundreds of compounds could be identified in even a small formula. With the regained enthusiasm on natural products based new drug R&D, the proposed multi-target drug discovery strategy, the booming of -omics technologies, and the implementation of ambitious plan of TCM modernization in China, attempts have been made to fill the gap between TCM herbs and modern drugs. However, are we heading to the right direction? Copyright © 2013 Elsevier Ltd. All rights reserved.

Strategy in Regulatory Decision-Making for Management of Progressive Multifocal Leukoencephalopathy

DEFF Research Database (Denmark)

Segec, A; Keller-Stanislawski, B; Vermeer, N S

2015-01-01

Progressive multifocal leukoencephalopathy (PML) has been observed after the use of several medicines, including monoclonal antibodies. As these drugs play important roles in the therapeutic armamentarium, it is important to address the challenges that this severe adverse reaction poses to the safe...... use of medicines. Considering the need for consistent outcomes of regulatory decisions, the European Medicines Agency Pharmacovigilance Risk Assessment Committee (PRAC) used PML as an example to develop a systematic approach to labeling and risk minimization....

Proceedings: Computer Science and Data Systems Technical Symposium, volume 1

Science.gov (United States)

Larsen, Ronald L.; Wallgren, Kenneth

1985-01-01

Progress reports and technical updates of programs being performed by NASA centers are covered. Presentations in viewgraph form are included for topics in three categories: computer science, data systems and space station applications.

The 1988 progress report of the Nuclear Safety and Protection Institut

International Nuclear Information System (INIS)

Anon.

1988-01-01

The 1988 progress report of the Nuclear Safety and Protection Institut (CEA, France). The Institute's fields of action involve: The activities and technical safety of the nuclear power plants, the environmental and human radiation protection which includes technical, health and medical aspects, the nuclear materials compatibility and control and the accident intervention actions. The 1988 Institute activities are characterized by the continuity of the previous technical safety directives, by the improvement of the nuclear risk communication and of the international cooperation [fr

100 Areas technical activities report, engineers - March 1951

Energy Technology Data Exchange (ETDEWEB)

1951-04-01

This is the monthly 100 areas technical activities report from the engineering division for the month of March 1951. It reports on engineering activities related directly to the different production reactors, and gives progress reports on various engineering projects which are in development by the engineering group.

Basic requirements of nuclear medicine services

Energy Technology Data Exchange (ETDEWEB)

Belcher, E H

1993-12-31

Technological progress in nuclear medicine continues, not always to the immediate advantage of the developing world. The capital expense, operational demands and maintenance requirements of ever more complex equipment, the consequent need for highly trained staff, the necessity to assure regular supplies of costly radioactive materials, all present problems to which compromise or alternative solutions must often be sought. This chapter constitutes an attempt to define the basic requirements for thr practice of nuclear medicine with respect to staff, equipment, accommodation, supplies and supporting services with particular reference to the needs of institutions in developing countries

Basic requirements of nuclear medicine services

International Nuclear Information System (INIS)

Belcher, E.H.

1992-01-01

Technological progress in nuclear medicine continues, not always to the immediate advantage of the developing world. The capital expense, operational demands and maintenance requirements of ever more complex equipment, the consequent need for highly trained staff, the necessity to assure regular supplies of costly radioactive materials, all present problems to which compromise or alternative solutions must often be sought. This chapter constitutes an attempt to define the basic requirements for thr practice of nuclear medicine with respect to staff, equipment, accommodation, supplies and supporting services with particular reference to the needs of institutions in developing countries

Medical application of nuclear science: nuclear medicine and production of radiopharmaceuticals

International Nuclear Information System (INIS)

Cornet, L.

1997-01-01

Nuclear science in attendance on medicine or from Radium to Radiopharmaceuticals. By a brief historical reminder of the evolution of the radioactivity and development of nuclear science, we could see a very early interest and application of the radioactivity in the medical field. Main steps: Detection of natural radioactivity/Discovery of artificial radioactivity/First treatment of leukaemia and thyroid/First nuclear reactor/First radioisotope laboratory in hospital/First scintigraphy/First radiopharmaceutical/First cyclotron and cyclotron products/First immunoscintigraphy/Biotechnology and radioisotope/Evolution of technics [equipment for diagnosis (imaging, scintigraphy) and therapy]/Evolution of production technics and concept of products (generators of Technetium) and machines, reactor, cyclotron/Evolution of importance and interest of nuclear medicine/Creation of international association of nuclear medicine and producers (example ARPR)/Evolution of safety and pharmaceuticals regulation. After the sixties, period extremely rich in invention of products, characterized by a high fertility specially due to a non-restrictive regulation in terms of safety and pharmaceutical consideration, the evolution of technics, the importance of costs (investment, research, healthcare and the evolution of the regulations) have smoothly but continuously transformed the contexts and different actors. Consequences and facts: Rationalization and standardization of the catalogues, total integration of radiopharmaceuticals into the pharmaceutical laws, stop of nuclear research reactors, increase of number of cyclotrons, transformation of size and role of the producers and nuclear centers, risk in supply of some raw materials like Molybdenum, medical nuclear application as a worldwide business

An Unprecedented Revolution in Medicinal Chemistry Driven by the Progress of Biological Science.

Science.gov (United States)

Chou, Kuo-Chen

2017-01-01

The eternal or ultimate goal of medicinal chemistry is to find most effective ways to treat various diseases and extend human beings' life as long as possible. Human being is a biological entity. To realize such an ultimate goal, the inputs or breakthroughs from the advances in biological science are no doubt most important that may even drive medicinal science into a revolution. In this review article, we are to address this from several different angles. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.org.

Bioethics for Technical Experts

Science.gov (United States)

Asano, Shigetaka

Along with rapidly expanding applications of life science and technology, technical experts have been implicated more and more often with ethical, social, and legal problems than before. It should be noted that in this background there are scientific and social uncertainty elements which are inevitable during the progress of life science in addition to the historically-established social unreliability to scientists and engineers. In order to solve these problems, therefore, we should establish the social governance with ‘relief’ and ‘reliance’ which enables for both citizens and engineers to share the awareness of the issues, to design social orders and criterions based on hypothetical sense of values for bioethics, to carry out practical use management of each subject carefully, and to improve the sense of values from hypothetical to universal. Concerning these measures, the technical experts can learn many things from the present performance in the medical field.

A review on primary progressive aphasia

Directory of Open Access Journals (Sweden)

Gabriel C Léger

2007-01-01

Full Text Available Gabriel C Léger1,2, Nancy Johnson31Neurology Service, Hôtel-Dieu du Centre Hospitalier de l’Univertité de Montréal, Montréal, Québec, Canada; 2Faculty of Medicine, Université de Montréal, Montréal, Québec, Canada; 3Cognitive Neurology and Alzheimer’s Disease Center, Department of Psychiatry and Behavioral Science, Northwestern University Feinberg School of Medicine, Chicago, IL, USAAbstract: Primary progressive aphasia (PPA is a neurodegenerative disease of insidious onset presenting with progressive isolated loss of language function, without significant impairment in other cognitive domains. Current diagnostic criteria require the language dysfunction to remain isolated for at least two years, and to remain the salient feature as the disease progresses, usually to involve other domains such as behavior, executive functions, and judgment. Although PPA in its early stages can usually be differentiated from probable Alzheimer’s disease (PRAD and the behavioral variant of frontotemporal lobar degeneration by the absence of significant changes in memory and behavior, and the preservation of activities daily living, progression of the disease often leads to deficits more consistent with the latter. Underlying etiologies remain heterogeneous: the neuropathological characteristics associated with frontotemporal lobar degeneration, cortocobasal degeneration, and motor neuron disease are usually found. There is a strong genetic susceptibility with affliction of first-degree relatives with similar disease in up to 40 to 50% in some series. Pathogenic mutations in genes coding for the proteins tau and progranulin have been isolated. These are leading to a better understanding of the neuropathological mechanisms and hopefully targeted disease-modifying therapy. Current therapy is limited to improving mood symptoms and targeting behavior changes as they develop. Referral to specialized centers where speech therapy, counseling, and education

Technical Progress and Development Directions of Oceanic Spatial Information Datum

Directory of Open Access Journals (Sweden)

BAO Jingyang

2017-10-01

Full Text Available This paper briefly analyzes the basic development and technical situation of oceanic spatial information datum, reviews the main processes of oceanic vertical datum and correlative oceanic tidal study, such as improvement and perfect methods of determining tidal station vertical datum, realizing form of vertical datum controlled by tidal station, effect on maintaining vertical datum by long-term tidal station, oceanic tidal model establishing, and also construction and transformation of tidal datum, and then forecasts the key development directions of oceanic spatial information datum on high-accuracy marine position service, vertical datum and the transferring model refinement and spatial datum application.

Bench-scale testing of on-line control of column flotation using a novel analyzer. Third quarterly technical progress report, April 1, 1993--June 30, 1993

Energy Technology Data Exchange (ETDEWEB)

1993-08-24

This document contains the third quarterly technical progress report for PTI`s Bench-Scale Testing Project of a circuit integrating PTI`s KEN-FLOTETM Column Flotation Technology and PTI`s On-Line Quality Monitor and Control System. The twelve-month project involves installation and testing of a 200--300 lb/hr. bench-scale flotation circuit at PETC`s Coal Preparation Process Research Facility (CPPRF) for two bituminous coals (Upper Freeport and Pittsburgh No. 8 Seam Raw Coals). Figure 1 contains the project plan, as well as the approach to completing the major tasks within the twelve-month project schedule. The project is broken down into three phases, which include: Phase I -- Preparation: The preparation phase was performed principally at PTI`s Calumet offices from October through December, 1992. It involved building of the equipment and circuitry, as well as some preliminary design and equipment testing; Phase II -- ET Circuit Installation and Testing: This installation and testing phase of the project was performed at PETC`s CPPRF from January through June, 1993, and was the major focus of the project. It involved testing of the continuous 200--300 lb/hr. circuit; and Phase III -- Project Finalization: The project finalization phase is occurring from July through September, 1993, at PTI`s Calumet offices and involves finalizing analytical work and data evaluation, as well as final project reporting. This Third Quarterly Technical Progress Report principally summarizes the results from the benchscale testing with the second coal (Pittsburgh No. 8 Seam Coal), which occurred in April through June, 1993. It also contains preliminary economic evaluations that will go into the Final Report, as well as the plan for the final reporting task.

Imaging and visual documentation in medicine

International Nuclear Information System (INIS)

Wamsteker, K.; Jonas, U.; Veen, G. van der; Waes, P.F.G.M. van

1987-01-01

DOCUMED EUROPE '87 was organized to provide information to the physician on the constantly progressing developments in medical imaging technology. Leading specialists lectured on the state-of-the-art of imaging technology and visual documentation in medicine. This book presents a collection of the papers presented at the conference. refs.; figs.; tabs

Prismatic displacement effect of progressive multifocal glasses on reaction time and accuracy in elderly people

OpenAIRE

Ellison, Ashton C; Campbell, A John; Robertson, M Clare; Sanderson, Gordon F

2014-01-01

Ashton C Ellison, A John Campbell, M Clare Robertson, Gordon F SandersonDunedin School of Medicine, Department of Medicine, Dunedin, New ZealandBackground: Multifocal glasses (bifocals, trifocals, and progressives) increase the risk of falling in elderly people, but how they do so is unclear. To explain why glasses with progressive addition lenses increase the risk of falls and whether this can be attributed to false projection, this study aimed to 1) map the prismatic displacement of a progr...

Evolution of Quality Assurance for Clinical Immunohistochemistry in the Era of Precision Medicine. Part 3: Technical Validation of Immunohistochemistry (IHC) Assays in Clinical IHC Laboratories.

Science.gov (United States)

Torlakovic, Emina E; Cheung, Carol C; D'Arrigo, Corrado; Dietel, Manfred; Francis, Glenn D; Gilks, C Blake; Hall, Jacqueline A; Hornick, Jason L; Ibrahim, Merdol; Marchetti, Antonio; Miller, Keith; van Krieken, J Han; Nielsen, Soren; Swanson, Paul E; Vyberg, Mogens; Zhou, Xiaoge; Taylor, Clive R

2017-03-01

Validation of immunohistochemistry (IHC) assays is a subject that is of great importance to clinical practice as well as basic research and clinical trials. When applied to clinical practice and focused on patient safety, validation of IHC assays creates objective evidence that IHC assays used for patient care are "fit-for-purpose." Validation of IHC assays needs to be properly informed by and modeled to assess the purpose of the IHC assay, which will further determine what sphere of validation is required, as well as the scope, type, and tier of technical validation. These concepts will be defined in this review, part 3 of the 4-part series "Evolution of Quality Assurance for Clinical Immunohistochemistry in the Era of Precision Medicine."

Rise of radiation protection: science, medicine and technology in society, 1896--1935

International Nuclear Information System (INIS)

Serwer, D.P.

1976-12-01

The history of radiation protection before World War II is treated as a case study of interactions between science, medicine, and technology. The fundamental concerns include the following: are how medical and technical decisions with social impacts are made under conditions of uncertainty; how social pressures are brought to bear on the development of science, medicine, and technology; what it means for medicine or technology to be scientific; why professional groups seek international cooperation; and the roles various professionals and organizations play in controlling the harmful side effects of science, medicine, and technology. These questions are addressed in the specific context of protection from the biological effects of x-rays and radium in medical use

Rise of radiation protection: science, medicine and technology in society, 1896--1935

Energy Technology Data Exchange (ETDEWEB)

Serwer, D.P.

1976-12-01

The history of radiation protection before World War II is treated as a case study of interactions between science, medicine, and technology. The fundamental concerns include the following: are how medical and technical decisions with social impacts are made under conditions of uncertainty; how social pressures are brought to bear on the development of science, medicine, and technology; what it means for medicine or technology to be scientific; why professional groups seek international cooperation; and the roles various professionals and organizations play in controlling the harmful side effects of science, medicine, and technology. These questions are addressed in the specific context of protection from the biological effects of x-rays and radium in medical use.

Proceedings: Computer Science and Data Systems Technical Symposium, volume 2

Science.gov (United States)

Larsen, Ronald L.; Wallgren, Kenneth

1985-01-01

Progress reports and technical updates of programs being performed by NASA centers are covered. Presentations in viewgraph form, along with abstracts, are included for topics in three catagories: computer science, data systems, and space station applications.

Sensitivity of climate change mitigation estimates to assumptions about technical change

International Nuclear Information System (INIS)

Dowlatabadi, H.

1998-01-01

With greater certainty in anthropogenic influence on observed changes in climate there is increasing pressure for agreements to control emissions of greenhouse gases ([HOUGHTON]). While it is difficult to assess the appropriate level of mitigation, it has been argued that flexibility in meeting emission targets offers significant economic savings. Such flexibility can be exercised in terms of timing of mitigation (i.e. delay) or geographic location of the intervention (e.g. permit trading and Joint-Implementation). Much of this insight is based on standard models of technical change in energy supply and demand. However, standard model formulations rarely consider: (i) a link between the pattern of technical change and policy interventions; (ii) economies of learning; and (iii) technical progress in discovery and recovery of oil and gas. While there is evidence to support the importance of these factors in historic patterns of technical progress, the data necessary to calibrate internally consistent economic models of these phenomena have not been available. In this paper simple representations of endogenous and induced technical change have been used to explore the sensitivity of mitigation cost estimates to how technical change is represented in energy economics models. The scenarios involve control of CO 2 emissions to limit its concentration to no more than 550 ppm(v), starting in the year 2000, and delayed to 2025. This sensitivity analysis has revealed four robust insights: (i) If endogenous technical change is assumed, expected business as usual emissions are higher than otherwise estimated - nevertheless, while 25% greater CO 2 control is required for meeting the CO 2 concentration target, the cost of mitigation is 40% lower; (ii) If technical progress in oil and gas discovery and recovery is assumed, energy use and CO 2 emissions increase by 75% and 65%, respectively above the standard estimates; (iii) If the economies of learning exhibited in various

Nuclear science and technology at epoch of scientific and technical revolution

International Nuclear Information System (INIS)

Petros'yants, A.M.

1979-01-01

It is pointed out at the great revolutionizing influence of practical application of the nuclear energy with development of scientific and technical progress. Nowadays atomic energy being directed on the peaceful application of it is acquiring in the life of society significance which is difficult to overestimate. Completely new branch of industry has been created which is as to technology, culture of production and precision is concerned, exceeding all which had been created by mankind. Now it is difficult to manage without atomic energy in every branch of industry, in agriculture, medicine and scientific researches. History and modern state are stated of the development of main directions of nuclear science and technology, in particular: in the field of charged particles physics; nuclear physics; production of transuranium elements. Particular place is occupied by the works on creation of new energy sources, in particular, using controlled thermonuclear reactions and energy of fission. One of the forms of utilization of plasma processes is creation of MHD - generators. Structure has been shown of development of nuclear energetics in the CMEA member-states. Main types of power reactors have been listed and their characteristics have been given. Perspectives of nuclear ships building is given, as well as perspectives of applications of radioisotopes and radiations in different fields of science and technology, in particular, in different branches of industry and in nuclear medicine. The role of CMEA is stated in organizing and co-ordination of efforts of the countries of socialism in the field of development of peaceful applications of nuclear energy [ru

World progress toward fusion energy

International Nuclear Information System (INIS)

Davies, N.A.

1989-01-01

The author discusses international progress in fusion research during the last three years. Much of the technical progress has been achieved through international collaboration in magnetic fusion research. This progress has stimulated political interest in a multinational effort, aimed at designing and possibly constructing the world's first experimental fusion reactor. This interest was reflected in recent summit-level discussions involving President Mitterand, General Secretary Gorbachev, and President Reagan. Most recently, the European Community (EC), Japan, the United States, and the U.S.S.R. have decided to begin serious preparation for taking the next step toward practical fusion energy. These parties have agreed to begin the design and supporting R and D for an International Thermonuclear Experimental Reactor (ITER) under the auspices of the International Atomic Energy Agency (IAEA). The initiation of this international program to prepare for a fusion test reactor is discussed

Pharmacological study on traditional Chinese medicine and natural product in China

Institute of Scientific and Technical Information of China (English)

Yong-xiang ZHANG

2017-01-01

China is abundant in natural medicinal resources. Natural medicine (NP), especially traditional Chinese medicine (TCM), have been widely employed in prevention and treatment of diseases in China for thousands of years, which make a great contribution to health care of Chinese people and the prosperity of the Chinese nation. TCM is the excellence culture inheritance of China and a medicine system with long history, tradition and unique theory and technique. Prescriptions or formula are the main form of TCM and the compatibility and composition of them are made up following the theory of TCM among which the theory of compatibility is the essential part. Clinical application and modern pharmacological study both demonstrated that TCM prescription possesses unique effect in comparison with chemical drugs. However, the pharmacological study of TCM prescription is very difficult due to multiple herbs which contain complicated chemical components in the prescription. So, the key point for the pharmacological study of TCM prescription is to elucidate its integrative effect and the mechanism of action. In recent years, great advances have been achieved in the research on TCM prescription and modern study of TCM prescription, including pharmacological and chemical studies, has becoming a hot research field in China. The pharmacological studies of TCM and NP are conducted with different ways and methods including holistic approaches in various experimental model animals and in vitro experiments in tissue, organ and cell models. In addition, a lot of new technics and methods such as″ omics″ technologies were employed in the molecular level studies, for example, researches on the mechanism of action of TCM and NP. In addition, a lot of new drugs have been developed from TCM prescriptions in China. The classical preparations of TCM, including decoction, pill, powder, ointment and pellet, etc, are prepared with traditional methods. While, the new preparations are similar to

Drones in medicine-The rise of the machines.

Science.gov (United States)

Balasingam, Manohari

2017-09-01

This is a medical kitty hawk moment. Drones are pilotless aircrafts that were initially used exclusively by the military but are now also used for various scientific purposes, public safety, and in commercial industries. The healthcare industry in particular can benefit from their technical capabilities and ease of use. Common drone applications in medicine include the provision disaster assessments when other means of access are severely restricted; delivering aid packages, medicines, vaccines, blood and other medical supplies to remote areas; providing safe transport of disease test samples and test kits in areas with high contagion; and potential for providing rapid access to automated external defibrillators for patients in cardiac arrest. Drones are also showing early potential to benefit geriatric medicine by providing mobility assistance to elderly populations using robot-like technology. Looking further to the future, drones with diagnostic imaging capabilities may have a role in assessing health in remote communities using telemedicine technology. The Federal Aviation Administration (FAA) in the United States and the European Aviation Safety Agency (EASA) in the European Union are some examples of legislative bodies with regulatory authority over drone usage. These agencies oversee all technical, safety, security and administrative issues related to drones. It is important that drones continue to meet or exceed the requirements specified in each of these regulatory areas. The FAA is challenged with keeping pace legislatively with the rapid advances in drone technology. This relative lag has been perceived as slowing the proliferation of drone use. Despite these regulatory limitations, drones are showing significant potential for transforming healthcare and medicine in the 21st century. © 2017 John Wiley & Sons Ltd.

The Emerging Role of Proteomics in Precision Medicine: Applications in Neurodegenerative Diseases and Neurotrauma.

Science.gov (United States)

Alaaeddine, Rana; Fayad, Mira; Nehme, Eliana; Bahmad, Hisham F; Kobeissy, Firas

2017-01-01

Inter-individual variability in response to pharmacotherapy has provoked a higher demand to personalize medical decisions. As the field of pharmacogenomics has served to translate personalized medicine from concept to practice, the contribution of the "omics" disciplines to the era of precision medicine seems to be vital in improving therapeutic outcomes. Although we have observed significant advances in the field of genomics towards personalized medicine , the field of proteomics-with all its capabilities- is still in its infancy towards the area of personalized precision medicine. Neurodegenerative diseases and neurotrauma are among the areas where the implementation of neuroproteomics approaches has enabled neuroscientists to broaden their understanding of neural disease mechanisms and characteristics. It has been shown that the influence of epigenetics, genetics and environmental factors were among the recognized factors contributing to the diverse presentation of a single disease as well as its treatment establishing the factor-disease interaction. Thus, management of these variable single disease presentation/outcome necessitated the need for factoring the influence of epigenetics, genetics, epigenetics, and other factors on disease progression to create a custom treatment plan unique to each individual. In fact, neuroproteomics with its high ability to decipher protein alterations along with their post translational modifications (PTMs) can be an ideal tool for personalized medicine goals including: discovery of molecular mechanisms underlying disease pathobiology, development of novel diagnostics, enhancement of pharmacological neurotherapeutic approaches and finally, providing a "proteome identity" for patients with certain disorders and diseases. So far, neuroproteomics approaches have excelled in the areas of biomarker discovery arena where several diagnostic, prognostic and injury markers have been identified with a direct impact on the

Radiological protection in medicine: work of ICRP Committee 3

International Nuclear Information System (INIS)

Vañó, E.; Cosset, J.M.; Rehani, M.M.

2012-01-01

Committee 3 of the International Commission on Radiological Protection (ICRP) is concerned with protection in medicine, and develops recommendations and guidance on the protection of patients, staff, and the public against radiation exposure in medicine. This paper presents an overview of the work of Committee 3 over recent years, and the work in progress agreed at the last annual meeting in Bethesda, MD in October 2011. The reports published by ICRP dealing with radiological protection in medicine in the last 10 years cover topics on: education and training in radiological protection; preventing accidental exposures in radiation therapy; dose to patients from radiopharmaceuticals; radiation safety aspects of brachytherapy; release of patients after therapy with unsealed radionuclides; managing patient dose in digital radiology and computed tomography; avoidance of radiation injuries from medical interventional procedures; pregnancy and medical radiation; and diagnostic reference levels in medical imaging. Three new reports will be published in the coming months dealing with aspects of radiological protection in fluoroscopically guided procedures outside imaging departments; cardiology; and paediatric radiology. The work in progress agreed by Committee 3 is also described.

Systems medicine advances in interstitial lung disease.

Science.gov (United States)

Greiffo, Flavia R; Eickelberg, Oliver; Fernandez, Isis E

2017-09-30

Fibrotic lung diseases involve subject-environment interactions, together with dysregulated homeostatic processes, impaired DNA repair and distorted immune functions. Systems medicine-based approaches are used to analyse diseases in a holistic manner, by integrating systems biology platforms along with clinical parameters, for the purpose of understanding disease origin, progression, exacerbation and remission.Interstitial lung diseases (ILDs) refer to a heterogeneous group of complex fibrotic diseases. The increase of systems medicine-based approaches in the understanding of ILDs provides exceptional advantages by improving diagnostics, unravelling phenotypical differences, and stratifying patient populations by predictable outcomes and personalised treatments. This review discusses the state-of-the-art contributions of systems medicine-based approaches in ILDs over the past 5 years. Copyright ©ERS 2017.

[Challenges of Digital Medicine].

Science.gov (United States)

Blaser, Jürg

2018-06-01

Challenges of Digital Medicine Abstract. Digitization is increasingly covering more and more sectors, including medicine. To ensure medical operation 365 × 24 hours, progressively more human and financial resources are necessary. The transformation of patient histories from paper into electronic patient records focused initially on documentation. Today, hospital information systems are increasingly used as a platform for the communication of all professionals involved in the patient process - in Switzerland, however, so far without providing patients direct access to their data. Digititizing processes intend to increase efficiency, but also to enhance clinical and administrative decision support and quality assurance. The introduction of the electronic patient record in Switzerland in 2020 is expected to provide cross-company, more complete documentation of patient care. Multimorbid patients, often treated in different institutions and by different specialists, should benefit from this in particular. Advances in artificial intelligence offer new opportunities in medicine. Challenges include ensuring reliable data protection, and better interoperability of the systems involved. Semantically structured, machine-readable data exchange is a necessity for both networked services and internationally competitive research.

Artificial intelligence in medicine

OpenAIRE

Scerri, Mariella; Grech, Victor E.

2016-01-01

Various types of artificial intelligence programs are already available as consultants to physicians, and these help in medical diagnostics and treatment. At the time of writing, extant programs constitute “weak” AI—lacking in consciousness and intentionality. With AI currently making rapid progress in all domains, including those of healthcare, physicians face possible competitors—or worse, claims that doctors may become obsolete. We will explore the development of AI and robotics in medicin...

Strategy in Regulatory Decision-Making for Management of Progressive Multifocal Leukoencephalopathy.

Science.gov (United States)

Segec, A; Keller-Stanislawski, B; Vermeer, N S; Macchiarulo, C; Straus, S M; Hidalgo-Simon, A; De Bruin, M L

2015-11-01

Progressive multifocal leukoencephalopathy (PML) has been observed after the use of several medicines, including monoclonal antibodies. As these drugs play important roles in the therapeutic armamentarium, it is important to address the challenges that this severe adverse reaction poses to the safe use of medicines. Considering the need for consistent outcomes of regulatory decisions, the European Medicines Agency Pharmacovigilance Risk Assessment Committee (PRAC) used PML as an example to develop a systematic approach to labeling and risk minimization. © 2015 American Society for Clinical Pharmacology and Therapeutics.

Present situation and proposal for nuclear medicine development

International Nuclear Information System (INIS)

Oliva Gonzalez, Juan P.

2003-01-01

In the present paper, the current situation of the Cuban nuclear medicine, after its introduction in the country in the 40s of the 20 th century and its expansion since 1962 and, particularly, from the installation of the first gamma camera in 1980, is analyzed. Nowadays, there is a total 14 Nuclear Medicine Departments or Services in our country within the National Oncology Networks and national Health System (SNS), which provide medical attention to the population depending on the nuclear equipment available A Program for the medical and technical personnel's training is proposed, as well as for gradual development of nuclear medicine department's (including the installation of gamma cameras, divided into two stages: 2003-2004 and 2005-2006). The prospective results of the proposed program are analyzed, as well as the impact on the populations health

Fifth technical meeting on quality

International Nuclear Information System (INIS)

Girard, A.

1998-01-01

This article reports on the 5th Technical Meeting on Quality which was held in San Diego on 20-22 October 1997 and which was attended by representatives of the Home and Joint Central Team and of manufacturers currently involved in the Large R and D projects. The meeting made progress towards the finalization of the ITER Quality Manual document for inclusion in the Final Design Report and the definition of the quality necessary for ITER procurement and construction

Environmental Research Division technical progress report: January 1986--October 1987

International Nuclear Information System (INIS)

1988-07-01

Technical process in the various research activities of Argonne National Laboratory's Environmental Research Division is reported for the period 1986-1987. Textual, graphic, and tabular information is used to briefly summarize (in separate chapters) the work of the Division's Atmospheric Physics, Environmental Effects Research, Fundamental Molecular Physics and Chemistry, and Organic Geochemistry and Environmental Instrumentation Programs. Information on professional qualifications, awards, and outstanding professional activities of staff members, as well as lists of publications, oral presentations, special events organized, and participants in educational programs, are provided in appendices at the end of each chapter. Individual projects under each division are processed separately for the data bases

Environmental Research Division technical progress report: January 1986--October 1987

Energy Technology Data Exchange (ETDEWEB)

1988-07-01

Technical process in the various research activities of Argonne National Laboratory's Environmental Research Division is reported for the period 1986-1987. Textual, graphic, and tabular information is used to briefly summarize (in separate chapters) the work of the Division's Atmospheric Physics, Environmental Effects Research, Fundamental Molecular Physics and Chemistry, and Organic Geochemistry and Environmental Instrumentation Programs. Information on professional qualifications, awards, and outstanding professional activities of staff members, as well as lists of publications, oral presentations, special events organized, and participants in educational programs, are provided in appendices at the end of each chapter. Individual projects under each division are processed separately for the data bases.

TREATMENT OF PSORIASIS WITH HOMEOPATHIC MEDICINES

Directory of Open Access Journals (Sweden)

V. A. Molochkov

2014-01-01

Full Text Available Background: Psoriasis is a disease with growing incidence predominantly affecting young and middle-aged patients. It is characterized by frequent exacerbations, insufficient efficacy of the routine therapy and common adverse effects. Thus, use of alternative therapies is of great importance. Aim: To assess efficacy and safety of homeopathic medicine Loma Lux Psoriasis in patients with different forms of psoriasis. Materials and methods: 45 patients with progressive (n=17 and stable (n=28 psoriasis and mean PASI (Psoriasis Area and Severity Index value 17.3 (5–30 were treated with homeopathic medicine Loma Lux Psoriasis in combination with topical medicines: salicylic Vaseline 2%, tar and naphthalane preparations, ointments with fluocinolone acetonide and mometasone, betametasone/salicylic acid combinations. Diet was also recommended. Results: After 12 weeks, significant improvement (PASI decrease 75–100% was demonstrated in 40%  of the patients including completely absent skin desquamation, resorption of psoriatic papules and patches with residual hyper- or depigmentation. 57.8% of the patient had moderate improvement (PASI decrease 25–75%. In one patient with only slight improvement (PASI decrease less than 25% treatment was prolonged for 4  weeks and significant improvement was achieved. Therapy was well tolerated in all patients. No side effects or treatment-related complications were reported. Clinical recover was associated with marked tendency to improvement of blood biochemistry and immunology: elevation of immunoregulatory index up to 1.6 and T-helpers content up to 44.3%. Conclusion: Homeopathic medicine Loma Lux Psoriasis is characterized by good efficacy and safety profile and may be recommended as addon to comprehensive treatment of stable and progressing psoriasis.

Nuclear medicine and imaging research (instrumentation and quantitative methods of evaluation)

International Nuclear Information System (INIS)

Beck, R.N.; Cooper, M.; Chen, C.T.

1992-07-01

This document is the annual progress report for project entitled ''Instrumentation and Quantitative Methods of Evaluation.'' Progress is reported in separate sections individually abstracted and indexed for the database. Subject areas reported include theoretical studies of imaging systems and methods, hardware developments, quantitative methods of evaluation, and knowledge transfer: education in quantitative nuclear medicine imaging

75 FR 18507 - International Cooperation on Harmonisation of Technical Requirements for Registration of...

Science.gov (United States)

2010-04-12

...] International Cooperation on Harmonisation of Technical Requirements for Registration of Veterinary Medicinal... guidance has been developed for veterinary use by the International Cooperation on Harmonisation of... associations to promote the international harmonization of regulatory requirements. FDA has participated in...

The trigger values in the environmental risk assessment for (veterinary) medicines in the European Union: a critical appraisal

NARCIS (Netherlands)

Montforts MHMM; SEC

2005-01-01

A critical appraisal of the data used for the establishment of the trigger values for the exposure of the aquatic environment to human medicines and the terrestrial environment to veterinary medicines leads to the recommendation to change these values. The (draft) technical guidance documents in

Medical humanities' challenge to medicine.

Science.gov (United States)

Macnaughton, Jane

2011-10-01

Medicine is predicated on a view of human nature that is highly positivist and atomistic. This is apparent in the way in which its students are taught, clinical consultations are structured and medical evidence is generated. The field of medical humanities originally emerged as a challenge to this overly narrow view, but it has rarely progressed beyond tinkering around the edges of medical education. This is partly because its practitioners have largely been working from within a pervasive medical culture from which it is difficult to break free, and partly because the field has been insufficiently armed with scholarly thinking from the humanities. This is beginning to change and there is a sign that research in medical humanities has the potential to mount a persuasive challenge to medicine's ways of teaching, working and finding out. This article problematizes medicine's narrow viewpoint, grounding its critique in philosophical ideas from phenomenology and pragmatism. I will reflect upon the historical context within which medical humanities has emerged and briefly examine specific examples of how its interdisciplinary approach, involving humanities scholars with clinicians and medical scientists, may develop new research directions in medicine. © 2011 Blackwell Publishing Ltd.

Technical writing versus technical writing

Science.gov (United States)

Dillingham, J. W.

1981-01-01

Two terms, two job categories, 'technical writer' and 'technical author' are discussed in terms of industrial and business requirements and standards. A distinction between 'technical writing' and technical 'writing' is made. The term 'technical editor' is also considered. Problems inherent in the design of programs to prepare and train students for these jobs are discussed. A closer alliance between industry and academia is suggested as a means of preparing students with competent technical communication skills (especially writing and editing skills) and good technical skills.

Annual progress report, July 1, 1979-June 30, 1980

International Nuclear Information System (INIS)

1980-01-01

Research progress is reported for the year 1979-1980. The report is divided into sections dealing individually with the divisions of Biomolecular and Cellular Science, Environmental Biology, and Nuclear Medicine. The sections have been individually entered into EDB

Dementia Etiologies and Remedies in Traditional Persian Medicine; A Review of Medicinal Plants and Phytochemistry.

Science.gov (United States)

Shirbeigi, Laila; Dalfardi, Behnam; Abolhassanzadeh, Zohreh; Nejatbakhsh, Fatemeh

2018-01-01

Dementia is a chronic neurodegenerative disease causing progressive and gradual impairment of different brain's cognitive functions. The prevalence of dementia is about 3 to 7% in different parts of the world. The aim of this study was to determine the etiologies of dementia according to the Traditional Persian Medicine scientists' viewpoint and introduce their recommended herbal remedies for this disease. The authors explored six main Traditional Persian Medicine textbooks for the disease of dementia, its etiologies and related recommended herbal treatments. Two main keywords of "Lisarghes" and" Nesyan" were searched for this purpose. Medical databases, including PubMed, Scopus, Google Scholar, and Science Direct were searched for related articles published between 1966 and 2016 to review the pharmacological components and active ingredients of suggested herbal medicines. According to the Traditional Persian Medicine, dementia is resulted from brain dystemperament, a condition caused by cold and moist or cold and dry tempers. To treat this disease, Traditional Persian scientists recommended various herbal remedies. Current studies have demonstrated that some of these medicinal plants have beneficial effects for the aforementioned disease, including acetyl cholinesterase inhibitory function, neuroprotective effects, and memory enhancing role. The Traditional Persian Medicine literature suggested different herbal remedies for treating dementia. Modern studies support the usefulness of some of these medicines. However, the effect of a large number of these remedies has remained unexamined, a matter which needs to be investigated in future researches. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.org.

The Relevance of Hyperbaric Oxygen to Combat Medicine

Science.gov (United States)

2001-06-01

and Hyperbaric Conditions [les Questions medicales a caractere oprationel liees aux conditions hypobares ou hyperbares ] To order the complete...UNCLASSIFIED Defense Technical Information Center Compilation Part Notice ADPO 11081 TITLE: The Relevance of Hyperbaric Oxygen to Combat Medicine...following component part numbers comprise the compilation report: ADPO11059 thru ADP011100 UNCLASSIFIED 25-1 The Relevance of Hyperbaric Oxygen to

Medicine and ionizing rays: a help sheet in analysing risks in nuclear medicine

International Nuclear Information System (INIS)

Gauron, C.

2006-01-01

This document first proposes the various applicable legal and regulatory texts concerning radioprotection in the medical sector (European directives, institutions in charge of radioprotection, general arrangements, regulatory texts concerning worker protection against ionizing radiations, personnel specialized in medical radio-physics, electro-radiology operators, quality control of medical devices, and nuclear medicine and radiology). The second part proposes a synthesis of useful knowledge for radioprotection in the case of nuclear medicine when performing in vivo diagnosis, positron emission tomography or PET being excluded. Several aspects are considered: the concerned personnel, the course of treatment procedures, the hazards, the identification of the risk associated with ionizing radiation, the risk assessment and the determination of exposure levels, the strategy to control the risks (reduction of risks, technical measures concerning the installation or the personnel, teaching and information, prevention and medical monitoring), and risk control assessment. The next parts present the same kind of information but for positron emission tomography or PET with Fluorine 18, for therapeutic practice without hospitalization (activity of iodine 137 less than 740 MBq), for therapeutic practice in case of hospitalization (iodine 137 activity greater than 740 MBq), and when taking patients into care after treatment in a nuclear medicine (in this last case, legal and regulatory information focus on patients)

Inertial fusion research: Annual technical report, 1985

International Nuclear Information System (INIS)

Larsen, J.T.; Terry, N.C.

1986-03-01

This report describes the inertial confinement fusion (ICF) research activities undertaken at KMS Fusion (KMSF) during 1985. It is organized into three main technical sections; the first covers fusion experiments and theoretical physics, the second is devoted to progress in materials development and target fabrication, and the third describes laser technology research. These three individual sections have been cataloged separately

Yucca Mountain Project technical status report (TSR), October 1989--March 1990

International Nuclear Information System (INIS)

1990-01-01

This Yucca Mountain Project Technical Status Report (TSR) on site characterization is the second in a series of reports that will be issued at approximately six-month intervals during site characterization. In addition, progress made toward the initiation and conduct of new site characterization activities is included. For this report, information on the technical progress made by Yucca Mountain Project participating organizations has been compiled covering the period from October 1989, through March 31, 1990. The status report consists of three sections: an introductory section; a section on the status of site characterization, which includes preparatory activities, sites programs, repository design, seals system design, waste package design, and performance assessment; and a reference section, which provides a complete listing of all published documents cited in the text. 59 refs

A Portfolio Analysis Tool for Measuring NASAs Aeronautics Research Progress toward Planned Strategic Outcomes

Science.gov (United States)

Tahmasebi, Farhad; Pearce, Robert

2016-01-01

Description of a tool for portfolio analysis of NASA's Aeronautics research progress toward planned community strategic Outcomes is presented. The strategic planning process for determining the community Outcomes is also briefly described. Stakeholder buy-in, partnership performance, progress of supporting Technical Challenges, and enablement forecast are used as the criteria for evaluating progress toward Outcomes. A few illustrative examples are also presented.

Technological advances in precision medicine and drug development.

Science.gov (United States)

Maggi, Elaine; Patterson, Nicole E; Montagna, Cristina

New technologies are rapidly becoming available to expand the arsenal of tools accessible for precision medicine and to support the development of new therapeutics. Advances in liquid biopsies, which analyze cells, DNA, RNA, proteins, or vesicles isolated from the blood, have gained particular interest for their uses in acquiring information reflecting the biology of tumors and metastatic tissues. Through advancements in DNA sequencing that have merged unprecedented accuracy with affordable cost, personalized treatments based on genetic variations are becoming a real possibility. Extraordinary progress has been achieved in the development of biological therapies aimed to even further advance personalized treatments. We provide a summary of current and future applications of blood based liquid biopsies and how new technologies are utilized for the development of biological therapeutic treatments. We discuss current and future sequencing methods with an emphasis on how technological advances will support the progress in the field of precision medicine.

The Rise of Mitochondria in Medicine

Science.gov (United States)

Picard, Martin; Wallace, Douglas C; Burelle, Yan

2016-01-01

Once considered exclusively the cell's powerhouse, mitochondria are now recognized to perform multiple essential cellular functions beyond energy production, impacting most areas of cell biology and medicine. Since the emergence of molecular biology and the discovery of pathogenic mitochondrial DNA defects in the 1980's, research advances have revealed a number of common human diseases which share an underlying pathogenesis involving mitochondrial dysfunction. Mitochondria undergo function-defining dynamic shape changes, communicate with each other, regulate gene expression within the nucleus, modulate synaptic transmission within the brain, release molecules that contribute to oncogenic transformation and trigger inflammatory responses systemically, and influence the regulation of complex physiological systems. Novel “mitopathogenic” mechanisms are thus being uncovered across a number of medical disciplines including genetics, oncology, neurology, immunology, and critical care medicine. Increasing knowledge of the bioenergetic aspects of human disease has provided new opportunities for diagnosis, therapy, prevention, and in connecting various domains of medicine. In this article, we overview specific aspects of mitochondrial biology that have contributed to – and likely will continue to enhance the progress of modern medicine. PMID:27423788

Annual progress report, July 1, 1979-June 30, 1980

Energy Technology Data Exchange (ETDEWEB)

1980-01-01

Research progress is reported for the year 1979-1980. The report is divided into sections dealing individually with the divisions of Biomolecular and Cellular Science, Environmental Biology, and Nuclear Medicine. The sections have been individually entered into EDB. (ACR)

History and progress of Japanese acupuncture.

Science.gov (United States)

Kobayashi, Akiko; Uefuji, Miwa; Yasumo, Washiro

2010-09-01

After Chiso brought acupuncture to Japan from Wu (China) in the sixth century, it has progressed in unique ways within the various historical milieus of the past 1500 years. Ishitsu-rei, the first medical law of Japan established in 701, explains the medical system of acupuncture in detail showing that acupuncture was being administered under the authorization of the national government. For the next 1200 years, acupuncture continued to be an important facet of public health in Japan. From the Azuchimomoyama through the Edo period, the knowledge exchange with China became active and people who studied in China developed new styles and techniques of acupuncture treatment and organized their own private schools or ryu-ha in Japan. In 1635, when the Edo government decided to close the country, Japan cut-off exchange with foreign countries for over 200 years. The national isolation caused some development that was unique to Japan. During that time, acupuncture filtered into people's everyday lives. Moxibustion, in particular, became popular as a treatment that ordinary people could practice by themselves. Also in this period of isolation, Western medicine was imported from Holland, the only country allowed to maintain trade with Japan. This novel modern medicine had a strong impact on Japanese medicine, which has its foundation of Chinese traditional medicine. At the same time, Japanese acupuncture was introduced into Europe via Holland. When Japan opened its borders in 1865 period, the new government was eager to accept Western culture to the extent of prohibiting the progress of Japanese acupuncture for a period of time. Even so, Japanese acupuncture has survived and flourished up to the present day due to the strong demand and the great efforts of the practitioners. Scientific studies are now in the process of establishing a firm evidence base for over a millennium of clinical use, respecting the classic ideas of the traditional treatment.

Intensive skills week for military medical students increases technical proficiency, confidence, and skills to minimize negative stress.

Science.gov (United States)

Mueller, Genevieve; Hunt, Bonnie; Wall, Van; Rush, Robert; Molof, Alan; Schoeff, Jonathan; Wedmore, Ian; Schmid, James; Laporta, Anthony

2012-01-01

The effects of stress induced cortisol on learning and memory is well documented in the literature.1-3 Memory and learning are enhanced at low levels while high levels are detrimental. Repetitive training in stressful situations enables management of the stress response4 as demonstrated by the high intensity training military members undergo to prepare for tactical situations. Appropriate management of one?s stress response is critical in the medical field, as the negative effects of stress can potentially hinder life-saving procedures and treatments. This also applies to physicians-in-training as they learn and practice triage, emergency medicine, and surgical skills prior to graduation. Rocky Vista University?s Military Medicine Honor?s Track (MMHT) held a week long high-intensity emergency medicine and surgical Intensive Skills Week (ISW), facilitated by military and university physicians, to advance students? skills and maximize training using the Human Worn Partial Surgical Task Simulator (Cut Suit). The short-term goal of the ISW was to overcome negative stress responses to increase confidence, technical and non-technical knowledge, and skill in surgery and emergency medicine in an effort to improve performance as third-year medical students. The long-term goal was to enhance performance and proficiency in residency and future medical practice. The metrics for the short-term goals were the focus of this pilot study. Results show an increase in confidence and decrease in perceived stress as well as statistically significant improvements in technical and non-technical skills and surgical instrumentation knowledge throughout the week. There is a correlative benefit to physician and non-physician military personnel, especially Special Operations Forces (SOF) medical personnel, from developing and implementing similar training programs when live tissue or cadaver models are unavailable or unfeasible. 2012.

Attitudes to evidence-based medicine of primary care physicians in Asir region, Saudi Arabia.

Science.gov (United States)

Khoja, T A; Al-Ansary, L A

2007-01-01

A questionnaire survey was made of primary health care physicians in Asir region, Saudi Arabia in 1999 to explore their awareness of and attitude towards evidence-based medicine. The 272 respondents welcomed the principles of evidence-based medicine. Awareness and use of extracting journals, review publications and databases was low. Pharmaceutical company sponsored journals were the most commonly read. Bibliographic databases could only be accessed by 13% of respondents and the Internet by only 6%. There was only partial understanding of technical terms used in evidence-based medicine. Absence of a local library and increased patient workload were seen by most respondents as the main obstacles to practising evidence-based medicine.

[AVIATION MEDICINE: THEORETICAL CONCEPTS AND FOCAL FUNDAMENTAL AND PRACTICAL ISSUES (for the 80th anniversary of the Research Test Center of Aerospace Medicine and Military Ergonomics)].

Science.gov (United States)

Zhdanko, I M; Pisarev, A A; Vorona, A A; Lapa, V V; Khomenko, M N

2015-01-01

The article discloses postulates of theoretical concepts that make the methodological basis for addressing the real-world aviation medicine challenges of humanizing aviator's environment, labor content and means, and health and performance maintenance. Under consideration are focal fundamental and practical issues arising with the technological progress in aviation and dealt with at the AF CRI Research Test Center of Aerospace Medicine and Military Ergonomics.

Network Medicine for Alzheimer's Disease and Traditional Chinese Medicine.

Science.gov (United States)

Jarrell, Juliet T; Gao, Li; Cohen, David S; Huang, Xudong

2018-05-11

Alzheimer’s Disease (AD) is a neurodegenerative condition that currently has no known cure. The principles of the expanding field of network medicine (NM) have recently been applied to AD research. The main principle of NM proposes that diseases are much more complicated than one mutation in one gene, and incorporate different genes, connections between genes, and pathways that may include multiple diseases to create full scale disease networks. AD research findings as a result of the application of NM principles have suggested that functional network connectivity, myelination, myeloid cells, and genes and pathways may play an integral role in AD progression, and may be integral to the search for a cure. Different aspects of the AD pathology could be potential targets for drug therapy to slow down or stop the disease from advancing, but more research is needed to reach definitive conclusions. Additionally, the holistic approaches of network pharmacology in traditional Chinese medicine (TCM) research may be viable options for the AD treatment, and may lead to an effective cure for AD in the future.

Progress of the radioactive waste management at the Dalat Nuclear Research Institute and the role of an IAEA technical co-operation project in this process

International Nuclear Information System (INIS)

Nang, N.T.; Ngoc, O.V.; Nhu Thuy, T.T.; Nghi, D.V.; Thu, N.T.

2002-01-01

At present, the main radioactive waste generator in Vietnam is the Dalat Nuclear Research Institute (DNRI). For safe management of radioactive waste generated from this nuclear center, in 1982 Soviet specialists newly constructed one combined technology system for low level radioactive waste management. The existing system consists of two main parts, a Liquid Radioactive Waste Treatment Station and a Storage/Disposal Facility. The liquid treatment station can in principle meet the needs for this nuclear center but disposal technology and storage/disposal facilities are not good enough both with respect to safety and economy, especially the storage/disposal facility placed in Dalat, the tourist city. In order to help DNRI and Vietnam to solve the radioactive waste management problem, the IAEA Technical Co-operation (TC) project VIE/9/007 was implemented in Vietnam. The facilities and IAEA experts provided under this project gradually help to develop radioactive waste management at DNRI, Vietnam. This paper outlines progress under way in the management of the radioactive waste at the Nuclear Research Institute (NRI), Dalat, Vietnam, and the role of the IAEA Technical Co-operation (TC) project in this process. (author)

Application of step-frequency radars in medicine

Science.gov (United States)

Anishchenko, L.; Alekhin, M.; Tataraidze, A.; Ivashov, S.; Bugaev, Alexander S.; Soldovieri, F.

2014-05-01

The paper summarizes results of step-frequency radars application in medicine. Remote and non-contact control of physiological parameters with modern bioradars provides a wide range of possibilities for non-contact remote monitoring of a human psycho-emotional state and physiological condition. The paper provides information about technical characteristics of bioradars designed at Bauman Moscow State Technical University and experiments using them. Results of verification experiment showed that bioradars of BioRASCAN type may be used for simultaneous remote measurements of breathing and heart rate parameters. In addition, bioradar assisted experiments for detecting of different sleep disorders are described. Their results proved that method of bioradiolocation allows correct estimation of obstructive sleep apnea severity compared to the polysomnography method, which satisfies standard medical recommendations.

Paradigm shifts in critical care medicine: the progress we have made.

Science.gov (United States)

Vincent, Jean-Louis; Creteur, Jacques

2015-01-01

There have really been no single, major, advances in critical care medicine since the specialty came into existence. There has, however, been a gradual, continuous improvement in the process of care over the years, which has resulted in improved patient outcomes. Here, we will highlight just a few of the paradigm shifts we have seen in processes of critical care, including the move from small, closed units to larger, more open ICUs; from a paternal "dictatorship" to more "democratic" team-work; from intermittent to continuous, invasive to less-invasive monitoring; from "more" interventions to "less" thus reducing iatrogenicity; from consideration of critical illness as a single event to realization that it is just one part of a trajectory; and from "four walls" to "no walls" as we take intensive care outside the physical ICU. These and other paradigm shifts have resulted in improvements in the whole approach to patient management, leading to more holistic, humane care for patients and their families. As critical care medicine continues to develop, further paradigm shifts in processes of care are inevitable and must be embraced if we are to continue to provide the best possible care for all critically ill patients.

Paradigm shifts in critical care medicine: the progress we have made

Science.gov (United States)

2015-01-01

There have really been no single, major, advances in critical care medicine since the specialty came into existence. There has, however, been a gradual, continuous improvement in the process of care over the years, which has resulted in improved patient outcomes. Here, we will highlight just a few of the paradigm shifts we have seen in processes of critical care, including the move from small, closed units to larger, more open ICUs; from a paternal "dictatorship" to more "democratic" team-work; from intermittent to continuous, invasive to less-invasive monitoring; from "more" interventions to "less" thus reducing iatrogenicity; from consideration of critical illness as a single event to realization that it is just one part of a trajectory; and from "four walls" to "no walls" as we take intensive care outside the physical ICU. These and other paradigm shifts have resulted in improvements in the whole approach to patient management, leading to more holistic, humane care for patients and their families. As critical care medicine continues to develop, further paradigm shifts in processes of care are inevitable and must be embraced if we are to continue to provide the best possible care for all critically ill patients. PMID:26728199

Toward precision medicine in primary biliary cholangitis.

Science.gov (United States)

Carbone, Marco; Ronca, Vincenzo; Bruno, Savino; Invernizzi, Pietro; Mells, George F

2016-08-01

Primary biliary cholangitis is a chronic, cholestatic liver disease characterized by a heterogeneous presentation, symptomatology, disease progression and response to therapy. In contrast, clinical management and treatment of PBC is homogeneous with a 'one size fits all' approach. The evolving research landscape, with the emergence of the -omics field and the availability of large patient cohorts are creating a unique opportunity of translational epidemiology. Furthermore, several novel disease and symptom-modifying agents for PBC are currently in development. The time is therefore ripe for precision medicine in PBC. In this manuscript we describe the concept of precision medicine; review current approaches to risk-stratification in PBC, and speculate how precision medicine in PBC might develop in the near future. Copyright © 2016 Editrice Gastroenterologica Italiana S.r.l. Published by Elsevier Ltd. All rights reserved.

Analytical Chemistry Division annual progress report for period ending December 31, 1979

International Nuclear Information System (INIS)

Shults, W.D.; Lyon, W.S.

1980-05-01

The progress is reported in the following sections: analytical methodology, mass and emission spectrometry, technical support, bio-organic analysis, nuclear and radiochemical analysis, and quality assurance

Progress Report. Teilinstitut Nukleare Festkoerperphysik

International Nuclear Information System (INIS)

Kaefer, K.

1978-10-01

This Progress Report of the Teilinstitut Nukleare Festkoerperphysik covers the work done at the Institute during the period from June 1, 1977 to May 31, 1978. The main research areas presently under investigation are underlined by the arrangement of the report: structure and dynamics of solids, electronic structure and magnetism of solids, and the development and investigation of novel materials. Some technical developments important in carrying out this research are included as well. (orig.) [de

Assessing Progress in Mastery of Counseling Communication Skills

NARCIS (Netherlands)

A.J. Kuntze (Jeroen)

2009-01-01

textabstractDuring the last century the attention paid in higher education to the development of professional skills has progressively increased. In the first half of the last century the term ‘skill’ mainly referred to motor or technical actions, for instance driving a car or operating a machine

Technical Assessment of Cryo-Compressed Hydrogen Storage Tank Systems for Automotive Applications

Energy Technology Data Exchange (ETDEWEB)

Ahluwalia, Rajesh [Argonne National Lab. (ANL), Argonne, IL (United States); Hua, T. Q. [Argonne National Lab. (ANL), Argonne, IL (United States); Peng, J. -K. [Argonne National Lab. (ANL), Argonne, IL (United States); Lasher, S. [TIAX LLC, Lexington, MA (United States); McKenney, Kurtis [TIAX LLC, Lexington, MA (United States); Sinha, J. [TIAX LLC, Lexington, MA (United States)

2009-12-01

Technical report describing DOE's second assessment report on a third generation (Gen3) system capable of storing hydrogen at cryogenic temperatures within a pressure vessel on-board a vehicle. The report includes an overview of technical progress to date, including the potential to meet DOE onboard storage targets, as well as independent reviews of system cost and energy analyses of the technology paired with delivery costs.

Consolidated fuel reprocessing program. Progress report, July 1-September 30, 1981

International Nuclear Information System (INIS)

1981-12-01

Technical progress is reported in overview fashion in the following areas: process development, laboratory R and D, engineering research, engineering systems, integrated equipment test facility (IET) operations, and HTGR fuel reprocessing

Technical and economic feasibility of membrane technology. Fourth technical progress report, June 17-September 16, 1980

Energy Technology Data Exchange (ETDEWEB)

Sandre, A.

1980-10-01

Progress is reported on the investigation of the potential application of reverse osmosis, ultrafiltration and electrodialysis to the system of solids concentration in beet sugar process streams. During this period, emphasis was put on running reverse osmosis tests with a new prototype machine to select the most suitable membranes for the concentrating of sugar solutions. An economic analysis of using reverse osmosis in a factory producing 10/sup 6/ gal/day of thin juice is discussed. (DMC)

Sport and medicine in ancient Greece.

Science.gov (United States)

Appelboom, T; Rouffin, C; Fierens, E

1988-01-01

Sport and medicine in ancient Greece were the result of a widespread tradition of liberty, which was at the heart of one of the most brilliant civilizations in history. Whereas war encouraged the development of surgical knowledge springing out of medical experience on the battlefield, peace promoted the burgeoning of sport as an integral part of Greek upbringing, allowing the channeling of young people's aggressiveness into physical competition. Medicine was magical and mythological, especially in the time of Homer (9th century BC); Aesculapius, the mythical god of healing, was its reference point. With Hippocrates (5th century BC), the body of medical experience was to be codified and built up, and was to undergo a novel evolution based on the theory of the balance of the four humors. The athlete's mentality, faced with trauma in the sports ground, underwent a change; injury was no longer considered a punishment by the gods. At the same time, temple offerings tendered in the hope of victory gave way to the athlete's personal preparation based on a specifically modified lifestyle, diet, and training. The resulting progress in medicine and public health, especially from the 5th century BC onward, was not only to favor athletic performances of high quality but also surgical techniques that were very advanced for their time. Thus it can be seen that the medical knowledge associated with the practice of sport progressed during antiquity because of its obligation to follow the warrior and then the athlete.

State of emergency medicine in Rwanda 2015: an innovative trainee and trainer model.

Science.gov (United States)

Mbanjumucyo, Gabin; DeVos, Elizabeth; Pulfrey, Simon; Epino, Henry M

2015-01-01

The 1994 Rwandan war and genocide left more than 1 million people dead; millions displaced; and the country's economic, social, and health infrastructure destroyed. Despite remaining one of the poorest countries in the world, Rwanda has made remarkable gains in health, social, and economic development over the last 20 years, but modern emergency care has been slow to progress. Rwanda has recently established the Human Resources for Health program to rapidly build capacity in multiple sectors of its healthcare delivery system, including emergency medicine. This project involves multiple medical and surgical residencies, nursing programs, allied health professional trainings, and hospital administrative support. A real strength of the program is that trainers work with international faculty at Rwanda's referral hospital, but also as emergency medicine specialty trainers when returning to their respective district hospitals. Rwanda's first emergency medicine trainees are playing a unique and important role in the implementation of emergency care systems and education in the country's district hospitals. While there has been early vital progress in building emergency medicine's foundations in Rwanda, there remains much work to be done. This will be accomplished with careful planning and strong commitment from the country's healthcare and emergency medicine leaders.

Analytical Chemistry Division annual progress report for period ending December 31, 1979

Energy Technology Data Exchange (ETDEWEB)

Shults, W.D.; Lyon, W.S. (ed.)

1980-05-01

The progress is reported in the following sections: analytical methodology, mass and emission spectrometry, technical support, bio-organic analysis, nuclear and radiochemical analysis, and quality assurance. (DLC)

Use of radiation technologies in agriculture and medicine

International Nuclear Information System (INIS)

Petukhov, V.K.; Chekushin, A.I.

1994-01-01

The most important directions of radiation and radiation biological technologies in the agriculture and medicine are elucidated. Kazakstan have possibility for application radiation technologies. There is powerful irradiation plant on the base of WWR-K reactor such could use for medicine materials sterilization. Has been proposed gamma-radiation plant with following technical characteristics: sources activity - 100-120 Ku; effective energy of radiation - 0,6-0,7 MeV; gamma-radiation use coefficient - 35 %; irradiation dose rate - 30-40 R/c; nonuniform irradiation rate - 12 %. Processing tools have being situated to hermetically sealed cylindrical container (height - 2 m; diameter - 1,2 m) and then have being put down under water towards gamma-irradiators

[Medicine and truth: between science and narrative].

Science.gov (United States)

Materia, Enrico; Baglio, Giovanni

2009-01-01

To which idea of truth may medicine refer? Evidence-based medicine (EBM) is rooted in the scientific truth. To explain the meaning and to trace the evolution of scientific truth, this article outlines the history of the Scientific Revolution and of the parable of Modernity, up to the arrival of pragmatism and hermeneutics. Here, the concept of truth becomes somehow discomfiting and the momentum leans towards the integration of different points of view. The fuzzy set theory for the definition of disease, as well as the shift from disease to syndrome (which has operational relevance for geriatrics), seems to refer to a more complex perspective on knowledge, albeit one that is less defined as compared to the nosology in use. Supporters of narrative medicine seek the truth in the interpretation of the patients' stories, and take advantage of the medical humanities to find the truth in words, feelings and contact with the patients. Hence, it is possible to mention the parresia, which is the frank communication espoused by stoicism and epicureanism, a technical and ethical quality which allows one to care in the proper way, a true discourse for one's own moral stance. Meanwhile, EBM and narrative medicine are converging towards a point at which medicine is considered a practical knowledge. It is the perspective of complexity that as a zeitgeist explains these multiple instances and proposes multiplicity and uncertainty as key referents for the truth and the practice of medicine.

JET Joint Undertaking. Progress report 1991 - volume 1

International Nuclear Information System (INIS)

1992-04-01

The ninth JET Progress Report provides an overview summary and puts into context the scientific and technical advances made on JET during 1991. The report contains a brief summary of the background to the project, and describes the basic objectives of JET and the principal design aspects of the machine

From Bertha Roentgen's hand to current medical imaging: one century of radiological progress

International Nuclear Information System (INIS)

Tubiana, M.

1997-01-01

From 1896 to 1996 radiology progressed at an amazing and unforeseen pace. The analysis of a few examples shows that these developments were due to a few groups and were enhanced by a close interaction between radiologists, physicists, engineers and manufacturers. Radiologists emphasize needs and are often able to suggest avenues for research; engineers exploit the basic discoveries of physicists and find new technologies. Manufacturers proceed from prototypes to instruments that can be built on an industrial scale at an affordable price. This system works efficiently only in a few developed countries. The gap between developing and developed countries is not narrowing and a large proportion of the world population has no access to adequate medical imaging. Very sophisticated imaging technologies used in industrialized countries are costly in terms of both money and human resources and in developing countries may usurp the limited assets that are needed for public health. Thus, the current challenge facing radiology is to take advantage of technological progress, firstly for building affordable and easy to maintain equipment giving images of sufficient quality, and secondly, through progress in telecommunications and computers, to improve medical education, telemedicine and build hospital networks. These networks will enable easier access to consultations with specialized radiologists and will give physicians the means of sharing their medical expertise. The aim is not only to narrow the gap but to provide a sufficient level of care in imaging medicine and radiotherapy throughout the world. This will only be achieved through a clear strategy and adequate human, technical and financial resources. The role of the radiological community, in particular ISR, RSNA and EAR, shall be crucial in this endeavour. (orig.)

Progress report of Technical Physics Division: April 1980 - March 1982

International Nuclear Information System (INIS)

Chaudhry, Ramesh; Vijendran, P.

1983-01-01

Activities, with an individual summary of each, of the Technical Physics Division (TPD) of the Bhabha Atomic Research Centre (BARC), Bombay are reported for the period April 1980 - March 1982. The major thrust of the TPD's work has been in: (i) design and fabrication of instruments, devices and equipment and (ii) development of techniques in the frontline research and technology areas like vacuum science, surface analysis, cryogenics and crystal growing. The Division also provided custombuilt electronics equipment, vacuum systems and glass components and devices to the various Divisions of BARC and other units of the DAE. Training and manpower development activities and technology transfer activities are also reported. Lists of seminars, colloquia, publications during the period of the report are given. (M.G.B.)

Technical minutes of the ninth INDC meeting. Vienna, 16-20 May 1977

International Nuclear Information System (INIS)

Motz, H.

1978-05-01

Progress reports from data centres on data measurements, facilities and evaluations, on coordinating activities are presented along with reports of technical, ad-hoc and policy subcommittees, on plans for cooperation and past meetings

Nuclear medicine. State of the art and future. Nuklearmedizin. Stand und Zukunft

Energy Technology Data Exchange (ETDEWEB)

Schmidt, H A.E.; Woldring, M [eds.

1978-01-01

This proceedings volume contains the compacts of about 200 papers on problems in nuclear medicine. The following subjects are treated in detail: computed tomography, data processing, radiopharmaceuticals, cyclotron products and technical equipment, osteology, oncology, nephrology, neurology, radiology, haematology, gastroenterology, pulmanology, thyroid, and radioimmunoassay.

University of Florida, University research program in robotics. Annual technical progress report

International Nuclear Information System (INIS)

Crane, C.D. III; Tulenko, J.S.

1994-05-01

Progress is reported in the areas of environmental hardening, database, world modeling, vision, man-machine interface, advanced liquid metal reactor inspection robot, and articulated transporter/manipulator system (ATMS) development

University of Florida, University research program in robotics. Annual technical progress report

Energy Technology Data Exchange (ETDEWEB)

Crane, C.D. III; Tulenko, J.S.

1994-05-01

Progress is reported in the areas of environmental hardening, database, world modeling, vision, man-machine interface, advanced liquid metal reactor inspection robot, and articulated transporter/manipulator system (ATMS) development.

Influence of admission marks on the academic performance of technical architecture students

OpenAIRE

Gaspar Fàbregas, Kàtia; Núñez Andrés, María Amparo; Rodríguez Jordana, Juan; Jordana Riba, Francisco de Paula

2016-01-01

Traditionally, students from higher training cycle and upper secondary school education access higher technical education with a wide range of access marks in each group. The purpose of this article is to analyse how students’ backgrounds and access marks really influence their success in the first academic year and further evolution to obtain the degree of Technical Architecture. To achieve this aim, the progress of students from different backgrounds was analysed for three acade...

Progress Report for Period Ending December 1961. Department of Reactor Physics

Energy Technology Data Exchange (ETDEWEB)

Tell, B [ed.

1962-08-15

This is the second Progress Report from the Department for Reactor Physics of Aktiebolaget Atomenergi, which is issued for the information of institutions and persons interested in the progress of the work. In this report the activities of the General Physics Section have been included, since this section nowadays belongs to the department. This is merely an informal progress report, and the results and data presented must be taken as preliminary. Final results will be submitted for publication either in the regular technical journals or as monographs in the series AE-reports.

Crystalline Repository Project. Technical progress report, October 1982-March 1983

International Nuclear Information System (INIS)

1985-01-01

This document reports the progress being made periodically on the development of a geologic repository in crystalline rock for the permanent disposal of high-level nuclear waste. The reporting elements are arranged by the work breakdown structure so that related studies are presented together. The studies are reported by the Office of Crystalline Respository Development (OCRD), a prime contractor of the US Department of Energy Repository Project Office. The studies include work by other prime contractors and by subcontractors to OCRD

Towards a space-borne quantum gravity gradiometer: progress in laboratory demonstration

Science.gov (United States)

Yu, Nan; Kohel, James M.; Kellogg, James R.; Maleki, Lute

2005-01-01

This paper describes the working principles and technical benefits of atom-wave interferometer-based inertial sensors, and gives a progress report on the development of a quantum gravity gradiometer for space applications at JPL.

Association Euratom - Risø National Laboratory, Technical University of Denmark - Annual Progress Report 2007

DEFF Research Database (Denmark)

Michelsen, Poul; Korsholm, Søren Bang; Juul Rasmussen, Jens

The programme of the Research Unit of the Fusion Association Euratom - Risø National Laboratory, Technical University of Denmark, covers work in fusion plasma physics and in fusion technology. The fusion plasma physics research focuses on turbulence and transport, and its interaction with the pla......The programme of the Research Unit of the Fusion Association Euratom - Risø National Laboratory, Technical University of Denmark, covers work in fusion plasma physics and in fusion technology. The fusion plasma physics research focuses on turbulence and transport, and its interaction...... phased out during 2007. Minor activities are system analysis, initiative to involve Danish industry in ITER contracts and public information. A summary is presented of the results obtained in the Research Unit during 2007....

IAEA Technical co-operation. A partner in development. Nuclear science serving people

International Nuclear Information System (INIS)

Kinley, D.; Perez Vargaz, J.

1997-01-01

This issue contains descriptions of IAEA technical cooperation programs in a variety of disciplines and locations. It includes articles on the eradication of Tsetse flies in Africa, biofertilizers for agriculture, new strains of rice, water resource management, pollution control for a sustainable environment, nuclear medicine, and ensuring nuclear reactor safety

Particle beam fusion progress report, January-June 1980

International Nuclear Information System (INIS)

1981-05-01

An overview and technical summaries are given for research progress in each of the following general areas: (1) fusion target studies; (2) target experiments; (3) particle beam source theory; (4) diagnostics development; (5) particle beam experiments; (6) pulsed power research and development; (7) pulse power application; and (8) Electron Beam Fusion Accelerator project

Effectiveness of medicines authentication technology to detect counterfeit, recalled and expired medicines: a two-stage quantitative secondary care study

Science.gov (United States)

Naughton, Bernard; Roberts, Lindsey; Dopson, Sue; Chapman, Stephen; Brindley, David

2016-01-01

Objectives To identify the authentication and detection rate of serialised medicines using medicines authentication technology. Design and intervention 4192 serialised medicines were entered into a hospital dispensary over two separate 8-week stages in 2015. Medicines were authenticated using secure external database cross-checking, triggered by the scanning of a two-dimensional data matrix with a unit specific 12-digit serial code. 4% of medicines included were preprogrammed with a message to identify the product as either expired, pack recalled, product recalled or counterfeit. Setting A site within a large UK National Health Service teaching hospital trust. Participants Accredited checking staff, pharmacists and dispensers in a pharmacy department. Primary outcome measures Authentication and detection rate of counterfeit expired and recalled medicines. Results The operational detection rate of counterfeit, recalled and expired medicines scanned as a combined group was 81.4% (stage 1 (S1)) and 87% (stage 2 (S2)). The technology's technical detection rate (TDR) was 100%; however, not all medicines were scanned and of those that were scanned not all that generated a warning message were quarantined. Owing to an operational authentication rate (OAR) of 66.3% (over both stages), only 31.8% of counterfeit medicines, 58% of recalled drugs and 64% of expired medicines were detected as a proportion of those entered into the study. Response times (RTs) of 152 ms (S1) and 165 ms (S2) were recorded, meeting the falsified medicines directive-mandated 300 ms limit. Conclusions TDRs and RTs were not a limiting factor in this study. The suboptimal OAR poses significant quality and safety issues with this detection approach. Authentication at the checking stage, however, demonstrated higher OARs. There is a need for further qualitative research to establish the reasons for less than absolute authentication and detection rates in the hospital environment to improve this

Theoretical particle physics. Technical progress report, May 1, 1985-April 30, 1986

International Nuclear Information System (INIS)

Gottlieb, S.A.; Hendry, A.W.; Kostelecky, V.A.; Lichtenberg, D.B.

1986-05-01

Research activities during this past year included theoretical work in lattice gauge theory, EMC effect, supersymmetry and supergravity, weak interactions including CP violation, and superstrings. Progress in all these areas is reported

[Recent advances in internal medicine].

Science.gov (United States)

Von Düring, Stephan; Mavrakanas, Thomas; Muller, Halima; Primmaz, Steve; Grosgurin, Olivier; Louis Simonet, Martine; Marti, Christophe; Nendaz, Mathieu; Serratrice, Jacques; Stirnemann, Jérome; Carballo, Sebastian; Darbellay Farhoumand, Pauline

2018-01-17

In medicine, there are progresses which radically transform practices, change recommendations and win unanimous support in the medical community. There are some which divide, questioning principles that seemed established. There are also small advances, which can answer the questions that internists ask themselves in the daily care of their patients. Here are several articles published in 2017, read and commented for you by hospitalists, selected according to their impact on the medical world.

Stem Cells in Regenerative Medicine

OpenAIRE

Sykova, Eva; Forostyak, Serhiy

2013-01-01

Background: A number of cardiovascular, neurological, musculoskeletal and other diseases have a limited capacity for repair and only a modest progress has been made in treatment of brain diseases. The discovery of stem cells has opened new possibilities for the treatment of these maladies, and cell therapy now stands at the cutting-edge of modern regenerative medicine and tissue engineering. Experimental data and the first clinical trials employing stem cells have shown their broad therapeuti...

NAEP 1999 Long-Term Trend Technical Analysis Report: Three Decades of Student Performance. NCES 2005-484

Science.gov (United States)

Allen, Nancy L.; McClellan, Catherine A.; Stoeckel, Joan J.

2005-01-01

This report provides an update to the technical analysis procedures documenting the 1996 National Assessment of Educational Progress (NAEP) as presented in "The NAEP 1996 Technical Report" (Allen, Carlson, and Zelenak, 1999). It describes how the 1999 long-term trend data were incorporated into the trend analyses. Since no national main…

Nuclear medicine and imaging research. Instrumentation and quantitative methods of evaluation. Progress report, January 15, 1985-January 14, 1986

International Nuclear Information System (INIS)

Beck, R.N.; Cooper, M.D.

1985-09-01

This program of research addresses problems involving the basic science and technology of radioactive tracer methods as they relate to nuclear medicine and imaging. The broad goal is to develop new instruments and methods for image formation, processing, quantitation, and display, so as to maximize the diagnostic information per unit of absorbed radiation dose to the patient. These developments are designed to meet the needs imposed by new radiopharmaceuticals developed to solve specific biomedical problems, as well as to meet the instrumentation needs associated with radiopharmaceutical production and quantitative clinical feasibility studies of the brain with PET VI. Project I addresses problems associated with the quantitative imaging of single-photon emitters; Project II addresses similar problems associated with the quantitative imaging of positron emitters; Project III addresses methodological problems associated with the quantitative evaluation of the efficacy of diagnostic imaging procedures. The original proposal covered work to be carried out over the three-year contract period. This report covers progress made during Year Three. 36 refs., 1 tab

An Emerging Complimentary Medicine-Yolk Oil Made from Heating Method

Directory of Open Access Journals (Sweden)

Tsung-Ming Hu

2012-07-01

Full Text Available Yolk oil is common in Asia. According to the Flora Sinensis, yolk oil is a multipurpose medicine, with specific dermatological and fever indications. Nowadays, it is generally used as a complimentary medicine for heart diseases. Yolk oil can be made from heating or chemical extraction method. It is generally believed that yolk oil made from heating (YOheat method is more effective as a medicine than that from extraction (YOext. The technical details of the heating method remain an issue of argument, including the degree of char and the threat of carcinogens formed during the heating process. Most yolk oil related studies used YOext as research material. Nevertheless, animal studies have showed that YOheat reduced triglycerides and total cholesterol in rodent liver. It is expected an easy-to-make complimentary medicine like YOheat may become even more common and thus evidence based studies should be conducted to verify its pharmacological effects and safety.

Assuring PSA technical adequacy for new advanced light water reactor designs

International Nuclear Information System (INIS)

Lutz, R.J.; Detar, H.L.; Schneider, R.E.

2012-01-01

The Probabilistic Safety Assessment (PSA) for an Advanced Light Water Reactor (ALWR) must exhibit a high level of technical adequacy, or technical quality, in order to be used as a reliable tool for making risk informed decisions concerning design and eventual operation of the plant. During the design phase, decisions on some design features may use the PSA as an input. Also, the PSA may be used as input to other operational decisions during plant design and construction including the development of procedures, development of technical specification limiting conditions for operation and scheduling of preventive maintenance activities. For the existing fleet of light water reactors (LWRs), PSA technical adequacy can be judged from wide ranging acceptance criteria such as the PRA (Probabilistic Risk Assessment) Standard in the United States of America that was developed jointly by the American Society of Mechanical Engineers (ASME) and the American Nuclear Society (ANS). However, the requirements for PRA technical adequacy in this PRA Standard assumes that the plant is built and has operation experience. Some of the requirements cannot be met for ALWRs in the design or construction phase and with no operational history. Key elements of a high level of technical adequacy include procedures, operator interviews, plant walk-downs and equipment reliability histories. The ability to include these key elements into the ALWR PSA to improve technical adequacy will progress as the ALWR progresses from the design stage through the construction stage and finally to the fuel load / pre-operational stage. As the technical adequacy becomes more robust, more confidence can be placed on risk-informed decisions that are made with the PSA. To assist in using the PSA as input to design and operational decisions in the design and construction stages of an ALWR, an addition to the ASME/ANS PRA Standard is being developed. The intent of this addition to the Standard is to provide

Pillars of peace: The evolution of nuclear technical cooperation

International Nuclear Information System (INIS)

Cetto, A.M.

2003-01-01

The twentieth century witnessed unprecedented scientific and technological progress, unfortunately paralleled by the development of weapons of mass destruction. And with this progress came an incredible amount of responsibility for scientists and governments. The creation of the IAEA and its technical cooperation programme brought together scientists and governments to use nuclear technology for the 'peaceful pursuits of mankind'. The programme supports application of nuclear techniques to solve socio-economic and human development problems in areas as diverse as agriculture, health, natural resource management, and radiation protection. Fifty years after President Eisenhower's famous 'Atoms for Peace' speech, the IAEA technical cooperation programme provides more than $70 million worth of experts, training, and procurement services each year to approximately 75% of its 137 Member States. But as development budgets shrink, the programme is seeking to make more meaningful use of resources at hand (national capacities, regional resources, development partners and the voluntary Technical Cooperation Fund), targeting specific problems of Member States and partnering with other sustainable development organizations. At the same time, efforts continue to overcome the past legacy that necessitated the 'Atoms for Peace' proposal in the first place. Even as development challenges are addressed, the IAEA, its partners and governments face other challenges along the way, including public opinion for a technology that had a devastating global introduction

Opportunities for the Cardiovascular Community in the Precision Medicine Initiative.

Science.gov (United States)

Shah, Svati H; Arnett, Donna; Houser, Steven R; Ginsburg, Geoffrey S; MacRae, Calum; Mital, Seema; Loscalzo, Joseph; Hall, Jennifer L

2016-01-12

The Precision Medicine Initiative recently announced by President Barack Obama seeks to move the field of precision medicine more rapidly into clinical care. Precision medicine revolves around the concept of integrating individual-level data including genomics, biomarkers, lifestyle and other environmental factors, wearable device physiological data, and information from electronic health records to ultimately provide better clinical care to individual patients. The Precision Medicine Initiative as currently structured will primarily fund efforts in cancer genomics with longer-term goals of advancing precision medicine to all areas of health, and will be supported through creation of a 1 million person cohort study across the United States. This focused effort on precision medicine provides scientists, clinicians, and patients within the cardiovascular community an opportunity to work together boldly to advance clinical care; the community needs to be aware and engaged in the process as it progresses. This article provides a framework for potential involvement of the cardiovascular community in the Precision Medicine Initiative, while highlighting significant challenges for its successful implementation. © 2016 American Heart Association, Inc.

Concerning nuclear medicine services. Notes on the practical situation in 1977

International Nuclear Information System (INIS)

Ducassou, Dominique.

1977-01-01

Nuclear medicine presents a certain number of teething problems, which are analysed here. An attempt is made first to estimate the worthwhileness or utility/cost ratio of a nuclear medicine service by determining firstly the expenses involved and secondly the services rendered. Problems connected with the running of nuclear medicine services are then discussed: civil and penal responsibility of the nuclear practitioner in relation to the human administration of radioactive preparations for diagnostic or therapeutic purposes; limited availability of scintillation cameras (1 for 500,000 inhabitants, a number considered hopelessly inadequate at the present time); organisation of premises; training of personnel (nuclear doctors, radiopharmacists, paramedical staff, technical staff). Finally the problems encountered in applying the nomenclature are dealt with [fr

31 CFR 560.533 - Brokering sales of agricultural commodities, medicine, and medical devices.

Science.gov (United States)

2010-07-01

... technical data, software, or information) that are subject to license application requirements of another... IRANIAN TRANSACTIONS REGULATIONS Licenses, Authorizations and Statements of Licensing Policy § 560.533 Brokering sales of agricultural commodities, medicine, and medical devices. (a) General license for...

[Integration of fundamental and applied medical and technical research made at the department of the biomedical systems, Moscow State Institute of Electronic Engineering].

Science.gov (United States)

Selishchev, S V

2004-01-01

The integration results of fundamental and applied medical-and-technical research made at the chair of biomedical systems, Moscow state institute of electronic engineering (technical university--MSIEE), are described in the paper. The chair is guided in its research activity by the traditions of higher education in Russia in the field of biomedical electronics and biomedical engineering. Its activities are based on the extrapolation of methods of electronic tools, computer technologies, physics, biology and medicine with due respect being paid to the requirements of practical medicine and to topical issues of research and design.

[Research advance in metabolism of effective ingredients from traditional Chinese medicines by probiotics].

Science.gov (United States)

Dai, Cheng-En; Li, Hai-Long; He, Xiao-Ping; Zheng, Fen-Fen; Zhu, Hua-Liu; Liu, Liang-Feng; Du, Wei

2018-01-01

The pharmacological activity of active ingredients from Chinese medicine depends greatly on the microecological environment of probiotics in the human body. After effective ingredients from traditional Chinese medicines are metabolized or biotransformed by probiotics, their metabolites can increase pharmacological activity, and can be absorbed more easily to improve the bioavailability. Therefore, the combination of Chinese medicines with probiotics is the innovation point in R&D of functional food and Chinese medicines, and also a new thinking for the modernization of Chinese medicine.This review summarizes and analyses the research progress on metabolism effects of gut microbiota on Chinese medicines components, the regulating effect of effective ingredients from Chinese medicine on intestinal probiotics, the application status of probiotics in traditional Chinese medicines, and the main problems and prospects in the research and development of Chinese medicines products with probiotic, aiming to provide theoretical guidance and practical value for the fermentation engineering of Chinese herbal medicine. Copyright© by the Chinese Pharmaceutical Association.

Recent progress on the traditional Chinese medicines that regulate the blood

Directory of Open Access Journals (Sweden)

Hsin-Yi Hung

2016-04-01

Full Text Available In traditional Chinese medicine, the herbs that regulate blood play a vital role. Here, nine herbs including Typhae Pollen, Notoginseng Root, Common Bletilla Tuber, India Madder Root and Rhizome, Chinese Arborvitae Twig, Lignum Dalbergiae Oderiferae, Chuanxiong Rhizoma, Corydalis Tuber, and Motherwort Herb were selected and reviewed for their recent studies on anti-tumor, anti-inflammatory and cardiovascular effects. Besides, the analytical methods developed to qualify or quantify the active compounds of the herbs are also summarized.

IAEA progress report. Highlights of report to ECOSOC

Energy Technology Data Exchange (ETDEWEB)

NONE

1959-07-15

The report notes that the application of radioisotope techniques to the general industrial economy is already well established in a number of the more developed countries, but because of rapid scientific and technical advance and the prospect of entirely new fields of utilization being opened up, the picture is continually changing with an increasing number of applications. The report states: 'The applications of radiation and radioisotopes in medicine and agriculture are most promising for the economic and social progress of the less developed countries, and the Agency, in consultation with WHO and FAO, is assisting in their promotion'. As for the medical uses of radioisotopes, the report describes diagnosis as 'a particularly important example of a complete change in the methods now being employed as a result of the use of radioisotope techniques'. It draws attention to the seminar on medical radioisotope scanning held in February under the joint auspices of IAEA and WHO, and to the award of contracts by IAEA for research on the medical applications of radioisotopes. Referring to the work being done in a number of advanced countries on the possibility of preserving food by irradiation, the report discloses that a survey of this work is being made by the Agency in consultation with FAO, in order to determine whether such applications would be economically feasible in the less developed areas of the world. The report says: 'it is expected that in the long run, the development of nuclear power will be the most important peaceful application of atomic energy, and that the Agency's assistance to Member States in this field will become its leading or at least one of its major activities'. It explains that the Agency's initial work is concerned with both the technical and economic aspects of the matter, with particular reference to the needs of the less developed countries. The report notes the importance of the Agency's work in the field of technical assistance and

The historical development of academic journals in occupational medicine, 1901-2009.

Science.gov (United States)

Smith, Derek R

2009-01-01

Academic journals in a specialist field provide an interesting historical record of its development and progression over time. This article describes the evolution of some major international journals of occupational medicine, including some historical background on their editorial board. As North America, the United Kingdom, and Northern Europe are known to have the highest contribution to scientific production, it was considered appropriate to investigate the main occupational medicine periodicals in these regions. Given the remarkable improvements in Japanese occupational health following the Second World War, it was also considered worthwhile to investigate the two English-language journals of occupational medicine from this country.

Biology and medicine division annual report, 1979-1980

International Nuclear Information System (INIS)

1981-03-01

Progress for 1979-1980 is reported from the following research groups and/or areas: research medicine; Donner Pavilion; Peralta Cancer Research Institute; environmental physiology; radiation biophysics and structural biophysics. Abstracts have been prepared for the 61 separate research programs described in this report for inclusion in the Energy Data Base

Chinese Herbal Medicine Meets Biological Networks of Complex Diseases: A Computational Perspective

OpenAIRE

Shuo Gu; Jianfeng Pei

2017-01-01

With the rapid development of cheminformatics, computational biology, and systems biology, great progress has been made recently in the computational research of Chinese herbal medicine with in-depth understanding towards pharmacognosy. This paper summarized these studies in the aspects of computational methods, traditional Chinese medicine (TCM) compound databases, and TCM network pharmacology. Furthermore, we chose arachidonic acid metabolic network as a case study to demonstrate the regula...

[Shippingport Station Decommissioning Project]: FY 1987 annual progress report, October 1, 1986-September 30, 1987

International Nuclear Information System (INIS)

1988-01-01

This report presents progress on the Shippingport Station Decommissioning Project for FY 1987. There are two main topics: Project Management and Decommissioning Project Activities. Changes from technical and managerial concepts developed in the original Decommissioning Plan are presented with the related technical, economic, or schedule considerations. 3 refs., 9 figs., 4 tabs

Shippingport Station Decommissioning Project: FY 1988 annual progress report, October 1, 1987--September 30, 1988

International Nuclear Information System (INIS)

1989-01-01

This report presents progress on the Shippingport Station Decommissioning Project for FY 1988. There are two main topics: Project Management and Decommissioning Project Activities. Changes from technical and managerial concepts developed in the original Decommissioning Plan are presented with the related technical, economic, or schedular considerations. 4 refs., 17 figs., 2 tabs

Women in medicine and dermatology: history and advances.

Science.gov (United States)

França, Katlein; Ledon, Jennifer; Savas, Jessica; Nouri, Keyvan

2014-01-01

The history of women in medicine has been marked by many challenges and achievements. Although the role of women in the "art of healing" can be traced back many centuries, only males are traditionally highlighted in history. Across antiquity, access to medical education was denied to females. Dermatology is a medical specialty in which women displayed particular skill and proficiency. Gradually, determination and competence allowed women to lay claim in an essentially male-dominated world. This article presents a brief review of the performance, progress and achievements of women in the history of medicine and dermatology.