Radiation safety and operational health physics of hospital based medical cyclotrons

International Nuclear Information System (INIS)

Mukherjee, B.

2002-01-01

Full text: Compact, low energy, high current Medical Cyclotrons are now primarily used to produce large activities of short lived, neutron deficient, positron- emitting radioisotopes. These isotopes constitute the key ingredients of important PET (Positron Emission Tomography) radiopharmaceuticals used in diagnostic nuclear medicine. The PET-radioisotope producing Medical Cyclotrons are now increasingly installed in modern urban hospitals in many countries of the world. Modern Medical Cyclotrons run at a very high beam current (∼100-200 micro Amp) level and thereby produce intense fields of parasitic gamma rays and neutrons, causing the activation of cyclotron components, ambient air and radiation exposure to patients and members of the public. This report highlights the important operational aspects and the characteristics of the radiation fields produced by Medical Cyclotrons. The pathways of personnel radiation exposure are also analyzed. The above information constitutes the scientific basis of a sound operational health physics service, which is manifested in an effective dose reduction and an enhanced radiological safety of the Medical Cyclotron facility within the framework of ALARA

Radiation safety and quality control in the cyclotron laboratory

International Nuclear Information System (INIS)

Sharma, S.; Krause, G.; Ebadi, M.

2006-01-01

Radiation safety was determined to maintain quality control in the cyclotron laboratory. Based on the results of 438 runs in the Faraday cup (20 μA for 10 min), 20 runs on 18 O-water target (40 μA for 2 h) and 10 runs on 18 O-gas targets (30 μA for 45 min), we have established that occupationally exposed workers remain 10 ± 5 times below federal regulatory limits (FRLs) in the cyclotron vault, 30 ± 8 times below FRL in the radiochemistry laboratory and 200 ± 10 times below the FRL outside the cyclotron laboratory during beam operation. (The FRL for unrestricted area are <20 μSv in 1 h.) The non-occupationally exposed workers serving in offices in the vicinity of the cyclotron vault within 100 m distance remained 200 times below the FRL irrespective of beam being on or off, suggesting that routine beam operation of 40 μA for 2 h once a day during office hours is safe provided quality control and system performance measures as discussed in this report are strictly maintained. (authors)

Development of a Medical Cyclotron Production Facility

Science.gov (United States)

Allen, Danny R.

2003-08-01

Development of a Cyclotron manufacturing facility begins with a business plan. Geographics, the size and activity of the medical community, the growth potential of the modality being served, and other business connections are all considered. This business used the customer base established by NuTech, Inc., an independent centralized nuclear pharmacy founded by Danny Allen. With two pharmacies in operation in Tyler and College Station and a customer base of 47 hospitals and clinics the existing delivery system and pharmacist staff is used for the cyclotron facility. We then added cyclotron products to contracts with these customers to guarantee a supply. We partnered with a company in the process of developing PET imaging centers. We then built an independent imaging center attached to the cyclotron facility to allow for the use of short-lived isotopes.

Development of a Medical Cyclotron Production Facility

International Nuclear Information System (INIS)

Allen, Danny R.

2003-01-01

Development of a Cyclotron manufacturing facility begins with a business plan. Geographics, the size and activity of the medical community, the growth potential of the modality being served, and other business connections are all considered. This business used the customer base established by NuTech, Inc., an independent centralized nuclear pharmacy founded by Danny Allen. With two pharmacies in operation in Tyler and College Station and a customer base of 47 hospitals and clinics the existing delivery system and pharmacist staff is used for the cyclotron facility. We then added cyclotron products to contracts with these customers to guarantee a supply. We partnered with a company in the process of developing PET imaging centers. We then built an independent imaging center attached to the cyclotron facility to allow for the use of short-lived isotopes

Radioisotope production with a medical cyclotron

International Nuclear Information System (INIS)

Silvester, D.J.

1974-01-01

The cyclotron of Hammersmith hospital in England was completed and started the operation in 1955. The feature is in its design operable at high beam current, reaching 500μA in internal beam and 300μA in external beam. In 1960's, twelve nuclides of radioactive pharmaceuticals were produced with the cyclotron. C-11, N-13 and O-15 have been used in the form of radioactive gases such as CO or H 2 O to test lung functions. F-18 has been used for bone scanning. K-43 is employed in the research of electrolyte balancing together with Na-24 and Br-77. Fe-52 is utilized in iron ion researches as a tracer. Cs-129 is highly evaluated as an isotope for imaging cardiac clogging part. Radioisotopes must be much more used in the examination of in vivo metabolic function. For this purpose, peculiarly labelled compounds should be further developed. It is welcome that the persons paying attention to the medical prospect of cyclotrons are increasing. The author hopes to continue his endeavour to find new products made with the cyclotron for human welfare. (Wakatsuki, Y.)

Calculation of the neutrons shielding in cyclotron accelerator

International Nuclear Information System (INIS)

Ribeiro, Martha S.; Sanches, Matias P.; Rodrigues, Demerval L.

2000-01-01

The objective of radioprotection in cyclotron facilities is to reduce the dose levels in the workplaces to classify them like supervised areas. In this way, the radiation dose rates in areas occupied by workers during cyclotron operations should not exceed 7,5 μSv/h. In controlled areas these levels are not observed and some rigorous controls must be exerted by administrative procedures or protection mechanisms. The Cyclotron Laboratory at IPEN-CNEN/SP has a cyclotron model Cyclone 30, 30 MeV, used for research and it is also used for radioisotopes production for medical diagnosis and therapeutical applications. Among them, 123 I, 67 Ga and 18 F can be pointed. When accelerator is operating, failures in perforations and paths that conduce to room accelerator can be occur and thus, the dose levels are higher than that established by law. For this reason, a review for shielding structure was necessary in order to optimize radiation dose. The purpose of this work was to determine the shielding thickness and adequate material to diminish the dose rates in workplaces to a value below 7,5 μSv/h. It was used a method to employ the equivalent dose value in the facility areas for neutrons fluency rate for the principal reactions in target irradiation processes. The purposed shielding for the vault doors ensures dose levels lower than established limits to supervised areas. (author)

Review of Cyclotrons for the Production of Radioactive Isotopes for Medical and Industrial Applications

Science.gov (United States)

Schmor, Paul

2011-02-01

Radioactive isotopes are used in a wide range of medical, biological, environmental and industrial applications. Cyclotrons are the primary tool for producing the shorter-lived, proton-rich radioisotopes currently used in a variety of medical applications. Although the primary use of the cyclotron-produced short-lived radioisotopes is in PET/CT (positron emission tomography/computed tomography) and SPECT (single photon emission computed tomography) diagnostic medical procedures, cyclotrons are also producing longer-lived isotopes for therapeutic procedures as well as for other industrial and applied science applications. Commercial suppliers of cyclotrons are responding by providing a range of cyclotrons in the energy range of 3-70MeV for the differing needs of the various applications. These cyclotrons generally have multiple beams servicing multiple targets. This review article presents some of the applications of the radioisotopes and provides a comparison of some of the capabilities of the various current cyclotrons. The use of nuclear medicine and the number of cyclotrons supplying the needed isotopes are increasing. It is expected that there will soon be a new generation of small "tabletop" cyclotrons providing patient doses on demand.

Treatment vault shielding for a flattening filter-free medical linear accelerator

Science.gov (United States)

Kry, Stephen F.; Howell, Rebecca M.; Polf, Jerimy; Mohan, Radhe; Vassiliev, Oleg N.

2009-03-01

The requirements for shielding a treatment vault with a Varian Clinac 2100 medical linear accelerator operated both with and without the flattening filter were assessed. Basic shielding parameters, such as primary beam tenth-value layers (TVLs), patient scatter fractions, and wall scatter fractions, were calculated using Monte Carlo simulations of 6, 10 and 18 MV beams. Relative integral target current requirements were determined from treatment planning studies of several disease sites with, and without, the flattening filter. The flattened beam shielding data were compared to data published in NCRP Report No. 151, and the unflattened beam shielding data were presented relative to the NCRP data. Finally, the shielding requirements for a typical treatment vault were determined for a single-energy (6 MV) linac and a dual-energy (6 MV/18 MV) linac. With the exception of large-angle patient scatter fractions and wall scatter fractions, the vault shielding parameters were reduced when the flattening filter was removed. Much of this reduction was consistent with the reduced average energy of the FFF beams. Primary beam TVLs were reduced by 12%, on average, and small-angle scatter fractions were reduced by up to 30%. Head leakage was markedly reduced because less integral target current was required to deliver the target dose. For the treatment vault examined in the current study, removal of the flattening filter reduced the required thickness of the primary and secondary barriers by 10-20%, corresponding to 18 m3 less concrete to shield the single-energy linac and 36 m3 less concrete to shield the dual-energy linac. Thus, a shielding advantage was found when the linac was operated without the flattening filter. This translates into a reduction in occupational exposure and/or the cost and space of shielding.

Treatment vault shielding for a flattening filter-free medical linear accelerator

Energy Technology Data Exchange (ETDEWEB)

Kry, Stephen F; Howell, Rebecca M; Polf, Jerimy; Mohan, Radhe; Vassiliev, Oleg N [Department of Radiation Physics, University of Texas M. D. Anderson Cancer Center, Houston, TX (United States)], E-mail: sfkry@mdanderson.org

2009-03-07

The requirements for shielding a treatment vault with a Varian Clinac 2100 medical linear accelerator operated both with and without the flattening filter were assessed. Basic shielding parameters, such as primary beam tenth-value layers (TVLs), patient scatter fractions, and wall scatter fractions, were calculated using Monte Carlo simulations of 6, 10 and 18 MV beams. Relative integral target current requirements were determined from treatment planning studies of several disease sites with, and without, the flattening filter. The flattened beam shielding data were compared to data published in NCRP Report No. 151, and the unflattened beam shielding data were presented relative to the NCRP data. Finally, the shielding requirements for a typical treatment vault were determined for a single-energy (6 MV) linac and a dual-energy (6 MV/18 MV) linac. With the exception of large-angle patient scatter fractions and wall scatter fractions, the vault shielding parameters were reduced when the flattening filter was removed. Much of this reduction was consistent with the reduced average energy of the FFF beams. Primary beam TVLs were reduced by 12%, on average, and small-angle scatter fractions were reduced by up to 30%. Head leakage was markedly reduced because less integral target current was required to deliver the target dose. For the treatment vault examined in the current study, removal of the flattening filter reduced the required thickness of the primary and secondary barriers by 10-20%, corresponding to 18 m{sup 3} less concrete to shield the single-energy linac and 36 m{sup 3} less concrete to shield the dual-energy linac. Thus, a shielding advantage was found when the linac was operated without the flattening filter. This translates into a reduction in occupational exposure and/or the cost and space of shielding.

Treatment vault shielding for a flattening filter-free medical linear accelerator

International Nuclear Information System (INIS)

Kry, Stephen F; Howell, Rebecca M; Polf, Jerimy; Mohan, Radhe; Vassiliev, Oleg N

2009-01-01

The requirements for shielding a treatment vault with a Varian Clinac 2100 medical linear accelerator operated both with and without the flattening filter were assessed. Basic shielding parameters, such as primary beam tenth-value layers (TVLs), patient scatter fractions, and wall scatter fractions, were calculated using Monte Carlo simulations of 6, 10 and 18 MV beams. Relative integral target current requirements were determined from treatment planning studies of several disease sites with, and without, the flattening filter. The flattened beam shielding data were compared to data published in NCRP Report No. 151, and the unflattened beam shielding data were presented relative to the NCRP data. Finally, the shielding requirements for a typical treatment vault were determined for a single-energy (6 MV) linac and a dual-energy (6 MV/18 MV) linac. With the exception of large-angle patient scatter fractions and wall scatter fractions, the vault shielding parameters were reduced when the flattening filter was removed. Much of this reduction was consistent with the reduced average energy of the FFF beams. Primary beam TVLs were reduced by 12%, on average, and small-angle scatter fractions were reduced by up to 30%. Head leakage was markedly reduced because less integral target current was required to deliver the target dose. For the treatment vault examined in the current study, removal of the flattening filter reduced the required thickness of the primary and secondary barriers by 10-20%, corresponding to 18 m 3 less concrete to shield the single-energy linac and 36 m 3 less concrete to shield the dual-energy linac. Thus, a shielding advantage was found when the linac was operated without the flattening filter. This translates into a reduction in occupational exposure and/or the cost and space of shielding.

The Medical Cyclotron Facility in RMC, Parel, BARC

International Nuclear Information System (INIS)

Gopalakrishna, Arjun; Banerjee, Sharmila

2017-01-01

The Medical Cyclotron Facility in Radiation Medicine Centre (RMC) is the first one of its kind, installed in 2002. "1"8F based radiotracers are produced in this facility on a routine basis for Positron Emission Tomography (PET), of in-house patients, as well as for supply to other nuclear medicine centers in Mumbai as well as Pune. The facility consists of the following sub parts - Cyclotron and support equipment; Radiochemistry synthesis laboratory; Quality control (QC) laboratory

Optimization approach for saddling cost of medical cyclotrons with fuzziness

International Nuclear Information System (INIS)

Abass, S.A.; Massoud, E.M.A.

2007-01-01

Most radiation fields are combinations of different kinds of radiation. The radiations of most significance are fast neutrons, thermal neutrons, primary gammas and secondary gammas. Thermos's composite shielding materials are designed to attenuate these types of radiation. The shielding design requires an accurate cost-benefit analysis based on uncertainty optimization technique. The theory of fuzzy sets has been employed to formulate and solve the problem of cost-benefit analysis of medical cyclotron. This medical radioisotope production cyclotron is based in Sydney, Australia

Operational experience and recent developments at the National Medical Cyclotron, Sydney

International Nuclear Information System (INIS)

Conard, E.M.; Arnott, D.W.

1996-01-01

The National Medical Cyclotron, Sydney, Australia commenced operation in mid 1991, with a mission to provide PET and SPECT radionuclides throughout Australia. The realization of the present production capacity has been synonymous with the development of the facility's industrial cyclotron (IBA Cyclone 30). The choice of cyclotron was based on the Cyclone 30's virtues as a compact, user-friendly, energy efficient cyclotron, offering the beam quality characteristic of negative ion technology. Development of the cyclotron has improved reliability and increased beam capacity, while improvements to targetry have increased production reliability. More recently, the installation and commissioning of a new solid target irradiation facility has provided much needed redundancy. This paper describes the major cyclotron and targetry developments carried out to date. (orig.)

Operational health and physics service during the maintenance of the Australian National Medical Cyclotron

International Nuclear Information System (INIS)

Mukherjee, B.

1994-01-01

Modern Medical Cyclotrons use intense beams of high energy protons or deuterons to produce large activities of short and medium lived radionuclides. After continuous operation for prolonged periods the Cyclotron components become activated through various nuclear interactions therefore, the risk of personal radiation hazard while handling such activated cyclotron components is high. This paper describes all operational aspects of the Health Physics service evolved during the first preventative maintenance program of the Australian National Medical Cyclotron, which took place in June 1993. 5 refs., 3 tabs., 2 figs

Medical cyclotrons

International Nuclear Information System (INIS)

Wolf, A.P.

1976-01-01

Cyclotrons as tools for therapy and for the production of radionuclides for use in nuclear medicine have been extensively reviewed in the literature. The current world status with respect to cyclotrons used primarily for research, development and application in nuclear medicine is reviewed here in the context of geographical distribution and type of use, presently available commercial types, machine characteristics and trends. Aspects of design requirements from a user perspective such as machine, beam and target characteristics are covered. Some special problems concerning many factors which can lead to effective production of the desired radionuclide or product are considered in light of machine characteristics. Consideration is also given to future directions for accelerators in nuclear medicine

Optimisation of the radiation shielding of medical cyclotrons using a genetic algorithm

International Nuclear Information System (INIS)

Mukherjee, Bhaskar

2000-01-01

Effective radiation shielding is imperative for safe operation of modern Medical Cyclotrons producing large activities of short-lived radioisotopes on a commercial basis. The optimal cyclotron shielding design demands a careful balance between the radiological, economical and often the sociopolitical factors. One is required to optimize the cost of radiation protection and the cost of radiological-health detriment. The cost of radiation protection depends explicitly on a) the nature of the radiation field produced by the cyclotron, b) the cyclotron operation condition, c) the cost of shielding material, d) the level of dose reduction, e) the projected net revenue from the sale of the radioisotopes, and f) the depreciation rate of the cyclotron facility. The Genetic Algorithm (GA) is used for a cost -benefit analysis of this problem. The GA is a mathematical technique that emulates the Darwinian Evolution paradigm. It is ideally suited to search for a global optimum in a large multi-dimensional solution space, having demonstrated strength compared to the classical analytical methods. Furthermore the GA method runs on a PC in a Windows environment. This paper highlights an interactive spreadsheet macro program for the cost benefit analysis of the optimize Medical Cyclotron shielding using a GA search engine. (author)

Radiation shielding analysis of medical cyclotron at Radiation Medicine Centre, Parel

International Nuclear Information System (INIS)

Gathibandhe, M.V.; Agrawal, R.A.; Utge, C.G.

2003-01-01

Full text: PET (Positron Emission Tomography) is a diagnostic method to obtain 3-D functional images of the distribution of radio-nuclides introduced in the human body as tracers for specific biological processes. Tracers are produced by bombardment of different target nuclides by protons and deuterons of high energy produced in the cyclotron. A Wipro-GE medical cyclotron was installed in the basement of RMC, Parel. Shielding around the cyclotron is provided in the form of borated concrete walls of required thickness to limit dose rates to design values as per AERB criteria. The roof of the cyclotron room is made of heavy concrete. Entry in to the room is through a maze. Shielding analysis for the cyclotron room has been carried out using computer code ANISN. The maze has been analyzed using code MCNP. Based on the analysis carried out additional shielding was recommended to meet the design requirements. The paper discusses the shielding analysis carried out for the cyclotron room and the maze. Dose rate estimated at various locations are highlighted

The National Medical Cyclotron - An Australian experience in technology

International Nuclear Information System (INIS)

Barnes, R. K.

1997-01-01

The establishment of the National Medical Cyclotron (NMC) in the early 1990's was the practical outcome of a vision, held by nuclear medicine professionals, to complement the available neutron-rich radionuclides produced in Australia, with neutron-deficient radionuclides. The NMC is operated by the Australian Nuclear Science and Technology Organisation (ANSTO) in collaboration with the Royal Prince Alfred Hospital (RPAH) in Sydney where the PET department is able to use the short-lived radiotracers to good advantage. Neutron-deficient radionuclides, are also produced by the NMC laboratories. The cyclotron-generated radionuclides are used in over 70,000 patient studies per year

Medical radioisotopes production at the isochronous cyclotron in Alma-Ata

International Nuclear Information System (INIS)

Arzumanov, A.A.; Batischev, V.N.; Gladun, V.K.; Kochetkov, V.L.

1988-01-01

High efficiency cyclotron operations (up to 5200 hours of beam time a year) considerably increased the possibility to perform both fundamental and applied scientific work. There appeared possibility to accelerate protons in a wide energy range from 6 to 30 MeV and realize correspondingly the nuclear reactions up to (A, 3n). This paper reports that among different applied tasks performed at the cyclotron the special program of cyclotron production of short-lived medical radioisotopes iodine-123, thallium-201, cadmium-109 in the first place and some others to satisfy clinic needs of Alma-Ata and its region has special importance. In accordance with this program the preparation to produce iodine-123 is being held and regular production of Thallium chloride, thallium-201 pharmaceptical is started

The National Medical Cyclotron - An Australian experience in technology

Energy Technology Data Exchange (ETDEWEB)

Barnes, R K [Australian Nuclear Science and Technology Organisation (ANSTO), Lucas Heights, NSW (Australia). National Medical Cyclotron

1998-12-31

The establishment of the National Medical Cyclotron (NMC) in the early 1990`s was the practical outcome of a vision, held by nuclear medicine professionals, to complement the available neutron-rich radionuclides produced in Australia, with neutron-deficient radionuclides. The NMC is operated by the Australian Nuclear Science and Technology Organisation (ANSTO) in collaboration with the Royal Prince Alfred Hospital (RPAH) in Sydney where the PET department is able to use the short-lived radiotracers to good advantage. Neutron-deficient radionuclides, are also produced by the NMC laboratories. The cyclotron-generated radionuclides are used in over 70,000 patient studies per year. 7 refs., 1 tab.

Cost benefit analysis of the radiological shielding of medical cyclotrons using a genetic algorithm

International Nuclear Information System (INIS)

Mukherjee, Bhaskar

2001-01-01

Adequate radiation shielding is vital to the safe operation of modern commercial medical cyclotrons producing large yields of short-lived radioisotopes. The radiological shielding constitutes a significant capital investment for any new cyclotron-based radioisotope production facility; hence, the shielding design requires an accurate cost-benefit analysis often based on a complex multi-variant optimization technique. This paper demonstrates the application of a Genetic Algorithm (GA) for the optimum design of the high yield target cave of a Medical Cyclotron radioisotope production facility based in Sydney, Australia. The GA is a novel optimization technique that mimics the Darwinian Evolution paradigm and is ideally suited to search for global optima in a large multi-dimensional solution space

Operational experience and recent developments at the National Medical Cyclotron

International Nuclear Information System (INIS)

Conard, E.; Pac, B.; Arnott, D.W.

1994-01-01

The National Medical Cyclotron is a radioisotope production facility run by ANSTO and located on the grounds of the Royal Prince Alfred Hospital in Sydney, Australia. A CYCLONE 30 (IBA) cyclotron is used in the production of short-lived PET radiopharmaceuticals required by the hospital's PET Scanner and also to produce a number of bulk radiochemicals for processing and distribution throughout Australasia. Following commissioning of the cyclotron and beam lines in October 1991, and the overcoming of a number of early open-quote teething close-quote problems especially relating to the reliability of the r.f. and solid target transport systems, a steady program of improvements has been pursued. These improvements have included development of new beam diagnostics and the design and installation of a new beam line for SPECT radioisotope production. The current operations schedule includes the production of 18 FDG, 13 NH 3 , 15 O 2 and 201 Tl, 67 Ga and 123 I. This paper will discuss the process of development of the cyclotron to ably meet the present demands on it, and the problems resolved in the pursuit of this goal

Nuclear waste vault sealing

International Nuclear Information System (INIS)

Gyenge, M.

1980-01-01

A nuclear waste vault must be designed and built to ensure adequate isolation of the nuclear wastes from human contact. Consequently, after a vault has been fully loaded, it must be adequately sealed off to prevent radionuclide migration which may be provided by circulating groundwater. Vault sealing entails four major aspects, i.e.: (a) vault grouting; (b) borehole sealing; (c) buffer packing; and (d) backfilling. Of particular concern in vault sealing are the physical and chemical properties of the sealing material, its long-term durability and stability, and the techniques used for its emplacement. Present sealing technology and sealing materials are reviewed in terms of the particular needs of vault sealing. Areas requiring research and development are indicated

Neutron transport calculation for Activation Evaluation for Decommissioning of PET cyclotron Facility

Science.gov (United States)

Nobuhara, Fumiyoshi; Kuroyanagi, Makoto; Masumoto, Kazuyoshi; Nakamura, Hajime; Toyoda, Akihiro; Takahashi, Katsuhiko

2017-09-01

In order to evaluate the state of activation in a cyclotron facility used for the radioisotope production of PET diagnostics, we measured the neutron flux by using gold foils and TLDs. Then, the spatial distribution of neutrons and induced activity inside the cyclotron vault were simulated with the Monte Calro calculation code for neutron transport and DCHAIN-SP for activation calculation. The calculated results are in good agreement with measured values within factor 3. Therefore, the adaption of the advanced evaluation procedure for activation level is proved to be important for the planning of decommissioning of these facilities.

Use of cyclotrons in medical research: Past, present, future

Science.gov (United States)

Smathers, James B.; Myers, Lee T.

1985-05-01

The use of cyclotrons in medical research started in the late 1930s with the most prominent use being neutron irradiation in cancer therapy. Due to a lack of understanding of the biological effect of neutrons, the results were less than encouraging. In the 1940s and 1950s, small cyclotrons were used for isotope production and in the mid 60s, the biological effect of neutrons was more thoroughly studied, with the result that a second trial of neutron therapy was initiated at Hammersmith Hospital, England. Concurrent with this, work on the use of high energy charged particles, initially protons and alphas, was initiated in Sweden and Russia and at Harvard and Berkeley. The English success in neutron therapy led to some pilot studies in the USA using physics cyclotrons of various energies and targets. These results in turn lead to the present series of machines presently being installed at M.D. Anderson Hospital (42 MeV), Seattle (50 MeV) and UCLA (46 MeV). The future probably bodes well for cyclotrons at the two extremes of the energy range. For nuclear medicine the shift is away from the use of multiple isotopes, which requires a large range of particles and energies to 11C, 13N, 15O, and 18F, which can be incorporated in metabolic specific compounds and be made with small 8-10 MeV p+ "table top" cyclotrons. For tumor therapy machines of 60 MeV or so will probably be the choice for the future, as they allow the treatment of deep seated tumors with neutrons and the charged particles have sufficient range to allow the treatment of ocular tumors.

Cyclotron vault design for PET complex of C CSR

International Nuclear Information System (INIS)

Fiilop, M.

2004-01-01

The Cyclotron center of the Slovak Republic will be built in two building (pavilion I and J), In the pavilion I there is planed to build up a complex for production, research and application of positron radiopharmaceuticals for PET (Positron Emission Tomography). Production of radiopharmaceuticals for SPECT (Single Photon Emission Computerized Tomography) and radiotherapy is situated in the pavilion J of Slovak Institute of Metrology. The radiation protection of personal and inhabitants against ionizing radiation in the PET Complex is solved with regard to the International Basic Safety Standards for Protection against Ionizing Radiation and for the Safety of Radiation Sources [1], ICRP recommendations [2] and Slovak regulatory system, protection rules and criteria and optimization of radiation protection

E-Area Vault Concrete Material Property And Vault Durability/Degradation Projection Recommendations

Energy Technology Data Exchange (ETDEWEB)

Phifer, M. A. [Savannah River Site (SRS), Aiken, SC (United States). Savannah River National Lab. (SRNL)

2014-03-11

Subsequent to the 2008 E-Area Low-Level Waste Facility (ELLWF) Performance Assessment (PA) (WSRC 2008), two additional E-Area vault concrete property testing programs have been conducted (Dixon and Phifer 2010 and SIMCO 2011a) and two additional E-Area vault concrete durability modeling projections have been made (Langton 2009 and SIMCO 2012). All the information/data from these reports has been evaluated and consolidated herein by the Savannah River National Laboratory (SRNL) at the request of Solid Waste Management (SWM) to produce E-Area vault concrete hydraulic and physical property data and vault durability/degradation projection recommendations that are adequately justified for use within associated Special Analyses (SAs) and future PA updates. The Low Activity Waste (LAW) and Intermediate Level (IL) Vaults structural degradation predictions produced by Carey 2006 and Peregoy 2006, respectively, which were used as the basis for the 2008 ELLWF PA, remain valid based upon the results of the E-Area vault concrete durability simulations reported by Langton 2009 and those reported by SIMCO 2012. Therefore revised structural degradation predictions are not required so long as the mean thickness of the closure cap overlying the vaults is no greater than that assumed within Carey 2006 and Peregoy 2006. For the LAW Vault structural degradation prediction (Carey 2006), the mean thickness of the overlying closure cap was taken as nine feet. For the IL Vault structural degradation prediction (Peregoy 2006), the mean thickness of the overlying closure cap was taken as eight feet. The mean closure cap thicknesses as described here for both E-Area Vaults will be included as a key input and assumption (I&A) in the next revision to the closure plan for the ELLWF (Phifer et al. 2009). In addition, it has been identified as new input to the PA model to be assessed in the ongoing update to the new PA Information UDQE (Flach 2013). Once the UDQE is approved, the SWM Key I

E-Area Vault Concrete Material Property And Vault Durability/Degradation Projection Recommendations

International Nuclear Information System (INIS)

Phifer, M. A.

2014-01-01

Subsequent to the 2008 E-Area Low-Level Waste Facility (ELLWF) Performance Assessment (PA) (WSRC 2008), two additional E-Area vault concrete property testing programs have been conducted (Dixon and Phifer 2010 and SIMCO 2011a) and two additional E-Area vault concrete durability modeling projections have been made (Langton 2009 and SIMCO 2012). All the information/data from these reports has been evaluated and consolidated herein by the Savannah River National Laboratory (SRNL) at the request of Solid Waste Management (SWM) to produce E-Area vault concrete hydraulic and physical property data and vault durability/degradation projection recommendations that are adequately justified for use within associated Special Analyses (SAs) and future PA updates. The Low Activity Waste (LAW) and Intermediate Level (IL) Vaults structural degradation predictions produced by Carey 2006 and Peregoy 2006, respectively, which were used as the basis for the 2008 ELLWF PA, remain valid based upon the results of the E-Area vault concrete durability simulations reported by Langton 2009 and those reported by SIMCO 2012. Therefore revised structural degradation predictions are not required so long as the mean thickness of the closure cap overlying the vaults is no greater than that assumed within Carey 2006 and Peregoy 2006. For the LAW Vault structural degradation prediction (Carey 2006), the mean thickness of the overlying closure cap was taken as nine feet. For the IL Vault structural degradation prediction (Peregoy 2006), the mean thickness of the overlying closure cap was taken as eight feet. The mean closure cap thicknesses as described here for both E-Area Vaults will be included as a key input and assumption (I and A) in the next revision to the closure plan for the ELLWF (Phifer et al. 2009). In addition, it has been identified as new input to the PA model to be assessed in the ongoing update to the new PA Information UDQE (Flach 2013). Once the UDQE is approved, the SWM Key I and

Important radiation protection aspects of the operation of a commercial medical cyclotron

International Nuclear Information System (INIS)

Mukherjee, B.

1997-01-01

Since July 1991 the Radiopharmaceutical Division of the Australian Nuclear Science and Technology Organisation (ANSTO) operates a 30 MeV H'- ion Medical Cyclotron (Model; CYCLONE 30, Manufacturer: Ion Beam Applications, Louvain La Neuve, Belgium). During routine isotope production operations at the cyclotron a thick copper substrate plate electroplated with thin layer of selected enriched target material are bombarded with 30 MeV proton beam current up to 450 μA. The nuclear reaction of protons with the copper atoms result in the reduction of prompt evaporation neutrons with a peak energy of ∼ 1.8 MeV. These evaporation neutrons slow down via multiple collisions with the concrete shielding walls of the target cave, bounce back to the,interior space of the cave activating the cyclotron parts, beam tube components and other utilities installed in the irradiation cave. After the completion of 60 hour isotope production run, gamma dose equivalent rates of ∼10 5 μSvh -1 were measured at contact with the target irradiation stations and beam collimators. Evidently, these gamma rays emitted from the activated cyclotron components impose crucial radiation exposure hazard problems for the cyclotron maintenance technicians. Experiments had been carried out in order to identify the specific pathways of cyclotron component activation and to assess the probable personnel radiation exposure during handling of the activated cyclotron parts. The cool-down (radioactive decay) of the activated cyclotron components was estimated experimentally at different target bombardment conditions using the wall mounted gamma area monitors interfaced to the Health Physics Data Acquisition System. The gamma dose equivalent rates at contact with various locations of interest at the target irradiation station and at the typical work areas of the maintenance personnel were carefully recorded with a radiation (gamma) survey instrument during the three years operation period of the cyclotron. A

Status of Simulations for the Cyclotron Laboratory at the Institute for Nuclear Research and Nuclear Energy

Science.gov (United States)

Asova, G.; Goutev, N.; Tonev, D.; Artinyan, A.

2018-05-01

The Institute for Nuclear Research and Nuclear Energy is preparing to operate a high-power cyclotron for production of radioisotopes for nuclear medicine, research in radiochemistry, radiobiology, nuclear physics, solid state physics. The cyclotron is a TR24 produced by ASCI, Canada, capable to deliver proton beams in the energy range of 15 to 24 MeV with current as high as 400 µA. Multiple extraction lines can be fed. The primary goal of the project is the production of PET and SPECT isotopes as 18F, 67,68Ga, 99mTc, etc. This contribution reports the status of the project. Design considerations for the cyclotron vault will be discussed for some of the target radioisotopes.

Vault mobility depends in part on microtubules and vaults can be recruited to the nuclear envelope

International Nuclear Information System (INIS)

Zon, Arend van; Mossink, Marieke H.; Houtsmuller, Adriaan B.; Schoester, Martijn; Scheffer, George L.; Scheper, Rik J.; Sonneveld, Pieter; Wiemer, Erik A.C.

2006-01-01

Vaults are ribonucleoproteins that may function in intracellular transport processes. We investigated the intracellular distribution and dynamics of vaults in non-small cell lung cancer cells in which vaults are labeled with the green fluorescent protein. Immunofluorescence experiments showed that vaults are dispersed throughout the cytoplasm; a small fraction is found in close proximity to microtubules. Immunoprecipitation experiments corroborated these results showing co-precipitation of MVP and β-tubulin. Using quantitative fluorescence-recovery after photobleaching (FRAP), we demonstrated that vault mobility over longer distances in part depends on intact microtubules; vaults moving slower when microtubules are depolymerized by nocodazole. Biochemical fractionation indicated a small fraction of MVP associated with the nucleus, however, no GFP-tagged vaults could be observed inside the nucleus. We observed an accumulation of vaults at the nuclear envelope upon treatment of cells with the protein synthesis inhibitor cycloheximide. Analysis of nucleo-cytoplasmic transport using a fluorescent substrate containing a classical NLS and NES expressed in MVP +/+ and MVP -/- mouse embryonic fibroblasts indicated no differences in nuclear import/export kinetics, suggesting no role for vaults in these processes. We hypothesize that a subset of vaults moves directionally via microtubules, possibly towards the nucleus

PRTR ion exchange vault column sampling

International Nuclear Information System (INIS)

Cornwell, B.C.

1995-01-01

This report documents ion exchange column sampling and Non Destructive Assay (NDA) results from activities in 1994, for the Plutonium Recycle Test Reactor (PRTR) ion exchange vault. The objective was to obtain sufficient information to prepare disposal documentation for the ion exchange columns found in the PRTR Ion exchange vault. This activity also allowed for the monitoring of the liquid level in the lower vault. The sampling activity contained five separate activities: (1) Sampling an ion exchange column and analyzing the ion exchange media for purpose of waste disposal; (2) Gamma and neutron NDA testing on ion exchange columns located in the upper vault; (3) Lower vault liquid level measurement; (4) Radiological survey of the upper vault; and (5) Secure the vault pending waste disposal

Shielding evaluation of a medical linear accelerator vault in preparation for installing a high-dose rate 252Cf remote after-loader

International Nuclear Information System (INIS)

Melhus, C. S.; Rivard, M. J.; KurKomelis, J.; Liddle, C. B.; Masse, F. X.

2005-01-01

In support of the effort to begin high-dose rate 252 Cf brachytherapy treatments at Tufts-New England Medical Center, the shielding capabilities of a clinical accelerator vault against the neutron and photon emissions from a 1.124 mg 252 Cf source were examined. Outside the clinical accelerator vault, the fast neutron dose equivalent rate was below the lower limit of detection of a CR-39 etched track detector and below 0.14 ± 0.02 μSv h -1 with a proportional counter, which is consistent, within the uncertainties, with natural background. The photon dose equivalent rate was also measured to be below background levels (0.1 μSv h -1 ) using an ionisation chamber and an optically stimulated luminescence dosemeter. A Monte Carlo simulation of neutron transport through the accelerator vault was performed to validate measured values and determine the thermal-energy to low-energy neutron component. Monte Carlo results showed that the dose equivalent rate from fast neutrons was reduced by a factor of 100,000 after attenuation through the vault wall, and the thermal-energy neutron dose equivalent rate would be an additional factor of 1000 below that of the fast neutrons. Based on these findings, the shielding installed in this facility is sufficient for the use of at least 5.0 mg of 252 Cf. (authors)

Trends in cyclotrons for radionuclide production

International Nuclear Information System (INIS)

Vera Ruiz, H.; Lambrecht, R.M.

1999-01-01

The IAEA recently concluded a worldwide survey of the cyclotrons used for radionuclide production. Most of the institutions responded to the questionnaire. The responses identified technical, utilisation and administrative information for 206 cyclotrons. Compiled data includes the characteristics, performance and popularity of each of the different commercial cyclotrons. Over 20 cyclotrons are scheduled for installation in 1998. The expansion in the number of cyclotron installations during the last decade was driven by the advent of advances in medical imaging instrumentation (namely, positron emission tomography (PET), and more recently by 511 KeV emission tomography); introduction of user friendly compact medical cyclotrons; and recent governmental decisions that permit reimbursement for cyclotron radiopharmaceutical studies by the government or insurance companies. The priorities for the production of clinical, commercial and research radionuclides were identified. The emphasis is on radionuclides used for medical diagnosis with SPET (e.g. 123 I, 201 Tl) and PET (e.g. 11 C, 13 N, 15 O, 18 F) radiopharmaceuticals, and for individualized patient radiation treatment planning (e.g. 64 Cu, 86 Y, 124 I) with PET. There is an emerging trend to advance the cyclotron as an alternative method to nuclear reactors for the production of neutron-rich radionuclides (e.g. 64 Cu, 103 Pd, 186 Re) needed for therapeutic applications. (authors)

Occupational radiation exposure at the self-shielded IBA CYCLONE 10/5, cyclotron of the Austin and Repatriation Medical Centre, Melbourne, Australia

International Nuclear Information System (INIS)

Tochon-Danguy, H.; Sachinidis, J.I.; U, P.; Egan, G.; Mukherjee, B.

1999-01-01

A series of health physics measurements was carried out at the IBA CYCLONE 10/5 Medical Cyclotron of the Austin and Repatriation Medical Centre, Melbourne. The neutron attenuation factor of the cyclotron shielding was estimated using the Superheated Bubble dosimeters. The neutron and gamma dose rates at various public access and radiation worker's area in the vicinity of the cyclotron facility were evaluated during the 11 C, 18 F, 13 N and 15 O production conditions. (authors)

Commercial cyclotrons. Part I: Commercial cyclotrons in the energy range 10 30 MeV for isotope production

Science.gov (United States)

Papash, A. I.; Alenitsky, Yu. G.

2008-07-01

A survey of commercial cyclotrons for production of medical and industrial isotopes is presented. Compact isochronous cyclotrons which accelerate negative hydrogen ions in the energy range 10 30 MeV have been widely used over the last 25 years for production of medical isotopes and other applications. Different cyclotron models for the energy range 10 12 MeV with moderate beam intensity are used for production of 11C, 13N, 15O, and 18F isotopes widely applied in positron emission tomography. Commercial cyclotrons with high beam intensity are available on the market for production of most medical and industrial isotopes. In this work, the physical and technical parameters of different models are compared. Possibilities of improving performance and increasing intensity of H- beams up to 2 3 mA are discussed.

Direct production of ^99mTc using a small medical cyclotron

Energy Technology Data Exchange (ETDEWEB)

Lapi, Suzanne [Washington Univ., St. Louis, MO (United States)

2017-10-03

This project describes an investigation towards the production of ^99mTc with a small medical cyclotron. This endeavor addresses the current urgent problem of availability of ^99mTc due to the ongoing production reactor failures and the upcoming Canadian reactor shut down. Currently, ^99mTc is produced via nuclear fission using highly enriched uranium which is a concern due to nuclear proliferation risks. In addition to this, the United States is dependent solely on currently unreliable foreign sources of this important medical isotope. Clearly, a need exists to probe alternative production routes of ^99mTc. In the first year, this project measured cross-sections and production yields of potential pathways to ^99mTc and associated radionuclidic impurities produced via these pathways using a small 15 MeV medical cyclotron. During the second and third years target systems for the production of ^99mTc via the most promising reaction routes were developed and separation techniques for the isolation of ^99mTc from the irradiated target material will be investigated. Systems for the recycling of the enriched target isotopes as well as automated target processing systems were examined in years four and five. This project has the potential to alleviate some of the current crisis in the medical community by developing a technique to produce ^99mTc on location at a university hospital. This technology will be applicable at many other sites in the United States as many other similar, low energy (<20 MeV) cyclotrons (currently used for a few hours per day for the production of [¹⁸F]fluorodeoxyglucose) are available for production of ^99mTc though this method, thus leading to job creation and preservation.

Kinematic variables of table vault on artistic gymnastics

Directory of Open Access Journals (Sweden)

Sarah Maria Boldrini FERNANDES

2016-03-01

Full Text Available Abstract The table vault is an event of male and female Artistics Gymnastics. Although it can be performed in a variety of rotations and body positions in different phases, it can be separated in three groups: handspring, Yurchenko and Tsukahara. It is believed that kinematic variables of vault may vary according to group of vault or gymnast body position, but few studies compares the real differences among the three groups of vaults, comparing and describing the variables in different phases. Vault kinematic variables could be diversifying according to the approach or position of the vaulting, but little has been studied about the biomechanical differences, comparing and describing behaviours at different stages. The aim of this study was to organize critical, objective and to systematize the most relevant kinematic variables to performance on vaulting. A Meta analysis over the basis Pubmed, Sport Discus and Web of Science were performed about this issue. From the selected references, we described and analyzed the kinematics of the table vault. Vault can be characterized in seven phases of analysis. Most of the studies are descriptive, and some do not descript all phases. Differences among vault variables according to group vaults, technical level and gender were analysed only in recent studies. There still gaps of knowledge about kinematic variables of table vault, in order to provide comprehensive information about all possibilities of vaults in this gymnastic event. It is concluded that kinematic variables of table vault depends upon vault group and may be considered to the improvement of technical performance. More researches are needed to approach the coaching interface with biomechanics applicable knowledge.

Neutron measurements at BRIT/BARC medical cyclotron facility of RMC, Parel

International Nuclear Information System (INIS)

Sathian, Deepa; Sathian, V.; Phandnis, U.V.; Soni, P.S.; Mohite, D.Y.

2005-01-01

Neutron leakage and its long distance propagation in the atmosphere from the intense neutron facilities such as high energy accelerators like Cyclotron are very important for the shielding design of the facilities and resulting dose reduction to nearby population, because of strong penetrability of high energy neutrons. The neutron interaction cross sections are highly energy dependent, so different methods are adopted for measuring different energy neutrons. The method also depends on the amount of neutron fluence rate expected at the location. When the fluence rate is very high, the foil activation is the best method for the measurement of neutron fluence rate. In foil activation technique an inactive material is activated by neutrons and the activity is measured and correlated to the neutron fluence rate. In this paper, neutron fluence rate measurement using different activation foils at medical cyclotron room of Radiation Medicine Centre (RMC) is discussed. (author)

THE ROLE OF THE CYCLOTRON IN MEDICAL RESEARCH

Energy Technology Data Exchange (ETDEWEB)

Hamilton, Joseph G.

1950-04-19

The uses of radioactive isotopes in medical research can be conveniently divided into three principal categories; namely, the applications as tracers for the study of metabolic phenomena, as diagnostic aids in clinical medicine, and finally their role in therapy. Frequently radioisotopes available from the chain-reacting pile do not have a sufficient degree of specific activity for satisfactory use. A number of radioisotopes which can be produced with high specific activity in the pile possess half-lives too short to be of any practical value. Then, there are a few cases in which the desired radioisotope may be made in the pile with high specific activity, but concomitantly there is formed another radioisotope of the same element whose half-life is of such duration as to render its use hazardous in man. Finally, there are several elements of biological and medical interest whose radioactive isotopes can be produced only by the cyclotron.

A real-time positron monitor for the estimation of stack effluent releases from PET medical cyclotron facilities

International Nuclear Information System (INIS)

Mukherjee, Bhaskar.

2002-01-01

Large activities of short-lived positron emitting radiopharmaceuticals are routinely manufactured by modern Medical Cyclotron facilities for positron emission tomography (PET) applications. During radiochemical processing, a substantial fraction of the volatile positron emitting radiopharmaceuticals are released into the atmosphere. An inexpensive, fast response positron detector using a simple positron-annihilation chamber has been developed for real-time assessment of the stack release of positron emitting effluents at the Australian National Medical Cyclotron. The positron detector was calibrated by using a 3.0 ml (1.50 MBq) aliquot of 18 FDG and interfaced to an industrial standard datalogger for the real-time acquisition of stack release data

Super-light pearl-chain arch vaults

DEFF Research Database (Denmark)

Hertz, Kristian Dahl; Halding, Philip Skov

2014-01-01

Arch vaults are known as optimal and impressive structures, but due to their curved shapes they are extremely costly to produce in countries, where the cost of labor is high. By means of super-light pearl-chain technology arch vaults can be constructed from equal plane prefabricated elements, which...... that it is also applicable as basic elements for super-light pearl-chain vaults. Machines and software have been developed for automatic mass production of the elements, and the first factory has started production in Denmark in 2014 delivering SL-deck elements for a variety of building projects. This means...... is known from curved voluminous elements. The paper describes the first full-scale test of an arch vault made of SL-deck elements demonstrating the principle, documenting the load-bearing capacity, and solving a number of details needed in order to create vaults in practice. Considerations and plans...

MRS using a FUELSTOR vault

International Nuclear Information System (INIS)

Valentine, M.K.; Gunther, H.

1992-01-01

Siemens Nuclear Power Corporation and Siemens-KWU have developed a dry-vault storage concept for interim storage of the nation's spent commercial nuclear fuel. This paper discusses the concept called a FUELSTOR vault which seals individual PWR fuel assemblies in an inert atmosphere within a welded canister, then stores the canisters in a horizontal array. The canisters are cooled passively by natural convection. The FUELSTOR vault assures safe, long-term storage with high fuel-storage density, and is designed for maximum radiation shielding and protection of the fuel against natural and man-made accidents

A new generation of medical cyclotrons for the 90's

International Nuclear Information System (INIS)

Milton, B.F.

1995-08-01

Cyclotrons continue to be efficient accelerators for use in radio-isotope production. In recent years, developments in accelerator technology have greatly increased the practical beam current in these machines while also improving the overall system reliability. These developments combined with the development of new isotopes for medicine and industry, and a retiring of older machines indicates a strong future for commercial cyclotrons. In this paper the authors will survey recent developments in the areas of cyclotron technology as they relate to the new generation of commercial cyclotrons. Existing and potential markets for these cyclotrons will be presented. They will also discuss the possibility of systems capable of extracted energies up to 150 MeV and extracted beam currents of up to 2.0 mA

A new generation of medical cyclotrons for the 90's

International Nuclear Information System (INIS)

Milton, B.F.

1995-08-01

Cyclotrons continue to be efficient accelerators for use in radio-isotope production. In recent years, developments in accelerator technology have greatly increased the practical beam current in these machines while also improving the overall system reliability. These developments combined with the development of new isotopes for medicine and industry, and a retiring of older machines indicates a strong future for commercial cyclotrons. In this paper we will survey recent developments in the areas of cyclotron technology as they relate to the new generation of commercial cyclotrons. Existing and potential markets for these cyclotrons will be presented. We will also discuss the possibility of systems capable of extracted energies up to 150 MeV and extracted beam currents of up to 2.0 mA. (author)

Cranial vault thickness in primates: Homo erectus does not have uniquely thick vault bones.

Science.gov (United States)

Copes, Lynn E; Kimbel, William H

2016-01-01

Extremely thick cranial vaults have been noted as a diagnostic characteristic of Homo erectus since the first fossil of the species was identified, but relatively little work has been done on elucidating its etiology or variation across fossils, living humans, or extant non-human primates. Cranial vault thickness (CVT) is not a monolithic trait, and the responsiveness of its layers to environmental stimuli is unknown. We obtained measurements of cranial vault thickness in fossil hominins from the literature and supplemented those data with additional measurements taken on African fossil specimens. Total CVT and the thickness of the cortical and diploë layers individually were compared to measures of CVT in extant species measured from more than 500 CT scans of human and non-human primates. Frontal and parietal CVT in fossil primates was compared to a regression of CVT on cranial capacity calculated for extant species. Even after controlling for cranial capacity, African and Asian H. erectus do not have uniquely high frontal or parietal thickness residuals, either among hominins or extant primates. Extant primates with residual CVT thickness similar to or exceeding H. erectus (depending on the sex and bone analyzed) include Nycticebus coucang, Perodicticus potto, Alouatta caraya, Lophocebus albigena, Galago alleni, Mandrillus sphinx, and Propithecus diadema. However, the especially thick vaults of extant non-human primates that overlap with H. erectus values are composed primarily of cortical bone, while H. erectus and other hominins have diploë-dominated vault bones. Thus, the combination of thick vaults comprised of a thickened diploë layer may be a reliable autapomorphy for members of the genus Homo. Copyright © 2015 Elsevier Ltd. All rights reserved.

A real-time intercepting beam-profile monitor for a medical cyclotron

Energy Technology Data Exchange (ETDEWEB)

Hendriks, C.; Uittenbosch, T.; Cameron, D.; Kellogg, S.; Gray, D.; Buckley, K.; Schaffer, P.; Verzilov, V.; Hoehr, C. [TRIUMF, 4004 Wesbrook Mall, Vancouver, British Columbia V6T 2A3 (Canada)

2013-11-15

There is a lack of real-time continuous beam-diagnostic tools for medical cyclotrons due to high power deposition during proton irradiation. To overcome this limitation, we have developed a profile monitor that is capable of providing continuous feedback about beam shape and current in real time while it is inserted in the beam path. This enables users to optimize the beam profile and observe fluctuations in the beam over time with periodic insertion of the monitor.

Rupture loop annex ion exchange RLAIX vault deactivation

Energy Technology Data Exchange (ETDEWEB)

Ham, J.E.; Harris, D.L., Westinghouse Hanford

1996-08-01

This engineering report documents the deactivation, stabilization and final conditions of the Rupture Loop Annex Ion Exchange (RLAIX) Vault located northwest of the 309 Building`s Plutonium Recycle Test Reactor (PRTR). Twelve ion exchange columns, piping debris, and column liquid were removed from the vault, packaged and shipped for disposal. The vault walls and floor were decontaminated, and portions of the vault were painted to fix loose contamination. Process piping and drains were plugged, and the cover blocks and rain cover were installed. Upon closure,the vault was empty, stabilized, isolated.

Study of the neutron field in the vicinity of an unshielded PET cyclotron

International Nuclear Information System (INIS)

Mendez, R; Iniguez, M P; MartI-Climent, J M; Penuelas, I; Vega-Carrillo, H R; Barquero, R

2005-01-01

The neutron field in the proximity of an unshielded PET cyclotron was investigated during 18 F radioisotope production with an 18 MeV proton beam. Thermoluminescent detector (TLD) models TLD600 and TLD700 as well as Bonner moderating spheres were irradiated at different positions inside the vault room where the cyclotron is located to determine the thermal neutron flux, neutron spectrum and dose equivalent. Furthermore, from a combination of measurements and Monte Carlo simulations the neutron source intensity at the target was estimated. The resulting intensity is in good agreement with the IAEA recommendations. Neutron doses derived from the measured spectra were found to vary between 7 and 320 mSv per 1 μA h of proton-integrated current. Finally, gamma doses were determined from TLD700 readings and amounted to around 10% of the neutron doses

Study of the neutron field in the vicinity of an unshielded PET cyclotron

Energy Technology Data Exchange (ETDEWEB)

Mendez, R [Dpto. Fisica Teorica, Atomica y Optica, Universidad de Valladolid (Spain); Iniguez, M P [Dpto. Fisica Teorica, Atomica y Optica, Universidad de Valladolid (Spain); MartI-Climent, J M [Servicio de Medicina Nuclear, ClInica Universitaria de Navarra (Spain); Penuelas, I [Servicio de Medicina Nuclear, ClInica Universitaria de Navarra (Spain); Vega-Carrillo, H R [Dpto. Estudios Nucleares, IngenierIa Electrica, Matematicas, Universidad Autonoma de Zacatecas (Mexico); Barquero, R [Hospital Universitario RIo Hortega, Valladolid (Spain)

2005-11-07

The neutron field in the proximity of an unshielded PET cyclotron was investigated during {sup 18}F radioisotope production with an 18 MeV proton beam. Thermoluminescent detector (TLD) models TLD600 and TLD700 as well as Bonner moderating spheres were irradiated at different positions inside the vault room where the cyclotron is located to determine the thermal neutron flux, neutron spectrum and dose equivalent. Furthermore, from a combination of measurements and Monte Carlo simulations the neutron source intensity at the target was estimated. The resulting intensity is in good agreement with the IAEA recommendations. Neutron doses derived from the measured spectra were found to vary between 7 and 320 mSv per 1 {mu}A h of proton-integrated current. Finally, gamma doses were determined from TLD700 readings and amounted to around 10% of the neutron doses.

PRTR ion exchange vault water removal

International Nuclear Information System (INIS)

Ham, J.E.

1995-11-01

This report documents the removal of radiologically contaminated water from the Plutonium Recycle Test Reactor (PRTR) ion exchange vault. Approximately 57,000 liters (15,000 gallons) of water had accumulated in the vault due to the absence of a rain cover. The water was removed and the vault inspected for signs of leakage. No evidence of leakage was found. The removal and disposal of the radiologically contaminated water decreased the risk of environmental contamination

Design of saltstone vaults

International Nuclear Information System (INIS)

Aiyar, G.S.; Hsiu, F.J.

1987-01-01

Radioactive waste from processed spent nuclear fuel at the Savannah River Plant, South Carolina, are stored in underground tanks. The wastes consist of sludge and supernate. Most of the radionuclides and some nonradioactive constituents are removed from the supernate. These along with the sludge are converted into a glass-crystallite matrix and cast into stainless steel cansisters for future disposal in a geological repository. The decontaminated salt solution is mixed with cement, fly ash, and a set-retarding agent, and the resulting grout is transferred to reinforced concrete vaults where it sets into a monolith termed saltstone. The vault is then capped with concrete. A total of 21 vaults measuring 600 x 100 x 27 ft are planned for disposal of the existing supernate plus any additional supernate generated up to the year 2000

Solid targets for 99mTc production on medical cyclotrons

International Nuclear Information System (INIS)

Hanemaayer, V.; Buckley, K.R.; Klug, J.; Ruth, T.J.; Schaffer, P.; Zeisler, S.K.; Benard, F.; Kovacs, M.; Leon, C.

2014-01-01

Recent disruptions in the molybdenum-technetium generator supply chain prompted a review of non-reactor based production methods for both 99 Mo and 99m Tc. Small medical cyclotrons (E p ∼ 16-24 MeV) are capable of producing Curie quantities of 99m Tc from isotopically enriched 100 Mo using the 100 Mo(p,2n) 99m Tc reaction. Unlike most other metallic target materials for routine production of medical radioisotopes, molybdenum cannot be deposited by reductive electroplating from aqueous salt solutions. To overcome this issue, we developed a new process for solid molybdenum targets based on the electrophoretic deposition of fine 100 Mo powder onto a tantalum plate, followed by high temperature sintering. The targets obtained were mechanically robust and thermally stable when irradiated with protons at high power density. (author)

Comparison of the production of medical radioisotopes on reactor and cyclotron

International Nuclear Information System (INIS)

Vucina, J.; Vuksanovic, Lj.; Dobrijevic, R.; Karanfilov, E.

1997-01-01

The production of radioisotopes for nuclear-medical applications can be performed either on nuclear reactor or on cyclotron. According to the nuclear reactions applied the radioisotopes of different physical characteristics can be produced. In the paper a comparison of the radioisotopes production given. Compared are the main steps in the production: choice of the nuclear reaction, targetry, irradiation and radiochemical separations performed on the irradiated target to isolate the desired radioisotope. The main characteristics of the produced radioisotopes are given and discussed. (author)

Ion source and injection line for high intensity medical cyclotron

Science.gov (United States)

Jia, XianLu; Guan, Fengping; Yao, Hongjuan; Zhang, TianJue; Yang, Jianjun; Song, Guofang; Ge, Tao; Qin, Jiuchang

2014-02-01

A 14 MeV high intensity compact cyclotron, CYCIAE-14, was built at China Institute of Atomic Energy (CIAE). An injection system based on the external H- ion source was used on CYCIAE-14 so as to provide high intensity beam, while most positron emission tomography cyclotrons adopt internal ion source. A beam intensity of 100 μA/14 MeV was extracted from the cyclotron with a small multi-cusp H- ion source (CIAE-CH-I type) and a short injection line, which the H- ion source of 3 mA/25 keV H- beam with emittance of 0.3π mm mrad and the injection line of with only 1.2 m from the extraction of ion source to the medial plane of the cyclotron. To increase the extracted beam intensity of the cyclotron, a new ion source (CIAE-CH-II type) of 9.1 mA was used, with maximum of 500 μA was achieved from the cyclotron. The design and test results of the ion source and injection line optimized for high intensity acceleration will be given in this paper.

Characterization of MVP and VPARP assembly into vault ribonucleoprotein complexes.

Science.gov (United States)

Zheng, Chun-Lei; Sumizawa, Tomoyuki; Che, Xiao-Fang; Tsuyama, Shinichiro; Furukawa, Tatsuhiko; Haraguchi, Misako; Gao, Hui; Gotanda, Takenari; Jueng, Hei-Cheul; Murata, Fusayoshi; Akiyama, Shin-Ichi

2005-01-07

Vaults are barrel-shaped cytoplasmic ribonucleoprotein particles composed of three proteins: the major vault protein (MVP), the vault poly(ADP-ribose)polymerase (VPARP), and the telomerase-associated protein 1, together with one or more small untranslated RNAs. To date, little is known about the process of vault assembly or about the stability of vault components. In this study, we analyzed the biosynthesis of MVP and VPARP, and their half-lives within the vault particle in human ACHN renal carcinoma cells. Using an immunoprecipitation assay, we found that it took more than 4h for newly synthesized MVPs to be incorporated into vault particles but that biosynthesized VPARPs were completely incorporated into vaults within 1.5h. Once incorporated into the vault complex, both MVP and VPARP were very stable. Expression of human MVP alone in Escherichia coli resulted in the formation of particles that had a distinct vault morphology. The C-terminal region of VPARP that lacks poly(ADP-ribose)polymerase activity co-sedimented with MVP particles. This suggests that the activity of VPARP is not essential for interaction with MVP-self-assembled vault-like particles. In conclusion, our findings provide an insight into potential mechanisms of physiological vault assembly.

New design for a medical cyclotron

Energy Technology Data Exchange (ETDEWEB)

Wilson, M

1985-12-01

The Oxford Instruments Group PLC, have designed a 30 MeV energy proton cyclotron incorporating a super-conducting magnet and a novel RF accelerating cavity. The energy range is suitable for the production of isotopes such as /sup 67/Ga, /sup 111/In, /sup 123/I and /sup 201/Tl, and the short lived isotopes of carbon, nitrogen, oxygen and fluorine for use in Positron Emmission Tomography (PET). A new magnet and RF cavity design permit a considerable power and weight reduction and a compact size (1.5m dia x 1.9m high), allowing the cyclotron to be transported to a shielded site as an assembly after factory testing. A method of beam extraction has been adopted which minimises activation of the accelerator components and so allows hands on maintenance to be carried out when required.

Future cyclotron systems : an industrial perspective

International Nuclear Information System (INIS)

Stevenson, N.R.; Dickie, W.J.

1995-09-01

The use of commercial cyclotron systems for the production of radioisotopes continues to grow on a world-wide scale. Improvements in technology have significantly increased the production capabilities of modem cyclotron-based isotope production facilities. In particular, the change to negative ion acceleration and new high power systems have resulted in dramatic improvements in reliability, increases in capacity, and decreases in personnel radiation dose. As more and more older machines are retired decisions regarding their replacement are made based on several factors including the market's potential and the cyclotron system's abilities. Taking the case of the recently upgraded TR30 cyclotron at TRIUMF/Nordion, we investigate the requirements industrial/medical users are likely to impose on future commercial cyclotron systems and the impact this will have on cyclotron technology by the end of the century. (author)

Future cyclotron systems: An industrial perspective

International Nuclear Information System (INIS)

Stevenson, N.R.; Dickie, W.J.

1995-09-01

The use of commercial cyclotron systems for the production of radioisotopes continues to grow on a world-wide scale. Improvements in technology have significantly increased the production capabilities of modern cyclotron-based isotope production facilities. In particular, the change to negative ion acceleration and new high power systems have resulted in dramatic improvements in reliability, increases in capacity, and decreases in personnel radiation dose. As more and more older machines are retired, decisions regarding their replacement are made based on several factors including the market's potential and the cyclotron system's abilities. Taking the case of the recently upgraded TR30 cyclotron at TRIUMF/Nordion, the authors investigate the requirements industrial/medical users are likely to impose on future commercial cyclotron systems and the impact this will have on cyclotron technology by the end of the century

Structure of the vault, a ubiquitous celular component.

Science.gov (United States)

Kong, L B; Siva, A C; Rome, L H; Stewart, P L

1999-04-15

The vault is a ubiquitous and highly conserved ribonucleoprotein particle of approximately 13 MDa. This particle has been shown to be upregulated in certain multidrug-resistant cancer cell lines and to share a protein component with the telomerase complex. Determination of the structure of the vault was undertaken to provide a first step towards understanding the role of this cellular component in normal metabolism and perhaps to shed some light on its role in mediating drug resistance. Over 1300 particle images were combined to calculate an approximately 31 A resolution structure of the vault. Rotational power spectra did not yield a clear symmetry peak, either because of the thin, smooth walls or inherent flexibility of the vault. Although cyclic eightfold (C8) symmetry was imposed, the resulting reconstruction may be partially cylindrically averaged about the eightfold axis. Our results reveal the vault to be a hollow, barrel-like structure with two protruding caps and an invaginated waist. Although the normal cellular function of the vault is as yet undetermined, the structure of the vault is consistent with either a role in subcellular transport, as previously suggested, or in sequestering macromolecular assemblies.

Kinematic variables of table vault on artistic gymnastics

OpenAIRE

FERNANDES,Sarah Maria Boldrini; CARRARA,Paulo; SERRÃO,Júlio Cerca; AMADIO,Alberto Carlos; MOCHIZUKI,Luis

2016-01-01

Abstract The table vault is an event of male and female Artistics Gymnastics. Although it can be performed in a variety of rotations and body positions in different phases, it can be separated in three groups: handspring, Yurchenko and Tsukahara. It is believed that kinematic variables of vault may vary according to group of vault or gymnast body position, but few studies compares the real differences among the three groups of vaults, comparing and describing the variables in different phases...

MVP and vaults: a role in the radiation response

International Nuclear Information System (INIS)

Lara, Pedro C; Pruschy, Martin; Zimmermann, Martina; Henríquez-Hernández, Luis Alberto

2011-01-01

Vaults are evolutionary highly conserved ribonucleoproteins particles with a hollow barrel-like structure. The main component of vaults represents the 110 kDa major vault protein (MVP), whereas two minor vaults proteins comprise the 193 kDa vault poly(ADP-ribose) polymerase (vPARP) and the 240 kDa telomerase-associated protein-1 (TEP-1). Additionally, at least one small and untranslated RNA is found as a constitutive component. MVP seems to play an important role in the development of multidrug resistance. This particle has also been implicated in the regulation of several cellular processes including transport mechanisms, signal transmission and immune responses. Vaults are considered a prognostic marker for different cancer types. The level of MVP expression predicts the clinical outcome after chemotherapy in different tumour types. Recently, new roles have been assigned to MVP and vaults including the association with the insulin-like growth factor-1, hypoxia-inducible factor-1alpha, and the two major DNA double-strand break repair machineries: non-homologous endjoining and homologous recombination. Furthermore, MVP has been proposed as a useful prognostic factor associated with radiotherapy resistance. Here, we review these novel actions of vaults and discuss a putative role of MVP and vaults in the response to radiotherapy

MVP and vaults: a role in the radiation response

Directory of Open Access Journals (Sweden)

Zimmermann Martina

2011-10-01

Full Text Available Abstract Vaults are evolutionary highly conserved ribonucleoproteins particles with a hollow barrel-like structure. The main component of vaults represents the 110 kDa major vault protein (MVP, whereas two minor vaults proteins comprise the 193 kDa vault poly(ADP-ribose polymerase (vPARP and the 240 kDa telomerase-associated protein-1 (TEP-1. Additionally, at least one small and untranslated RNA is found as a constitutive component. MVP seems to play an important role in the development of multidrug resistance. This particle has also been implicated in the regulation of several cellular processes including transport mechanisms, signal transmission and immune responses. Vaults are considered a prognostic marker for different cancer types. The level of MVP expression predicts the clinical outcome after chemotherapy in different tumour types. Recently, new roles have been assigned to MVP and vaults including the association with the insulin-like growth factor-1, hypoxia-inducible factor-1alpha, and the two major DNA double-strand break repair machineries: non-homologous endjoining and homologous recombination. Furthermore, MVP has been proposed as a useful prognostic factor associated with radiotherapy resistance. Here, we review these novel actions of vaults and discuss a putative role of MVP and vaults in the response to radiotherapy.

MVP and vaults: a role in the radiation response.

Science.gov (United States)

Lara, Pedro C; Pruschy, Martin; Zimmermann, Martina; Henríquez-Hernández, Luis Alberto

2011-10-31

Vaults are evolutionary highly conserved ribonucleoproteins particles with a hollow barrel-like structure. The main component of vaults represents the 110 kDa major vault protein (MVP), whereas two minor vaults proteins comprise the 193 kDa vault poly(ADP-ribose) polymerase (vPARP) and the 240 kDa telomerase-associated protein-1 (TEP-1). Additionally, at least one small and untranslated RNA is found as a constitutive component. MVP seems to play an important role in the development of multidrug resistance. This particle has also been implicated in the regulation of several cellular processes including transport mechanisms, signal transmission and immune responses. Vaults are considered a prognostic marker for different cancer types. The level of MVP expression predicts the clinical outcome after chemotherapy in different tumour types. Recently, new roles have been assigned to MVP and vaults including the association with the insulin-like growth factor-1, hypoxia-inducible factor-1alpha, and the two major DNA double-strand break repair machineries: non-homologous endjoining and homologous recombination. Furthermore, MVP has been proposed as a useful prognostic factor associated with radiotherapy resistance. Here, we review these novel actions of vaults and discuss a putative role of MVP and vaults in the response to radiotherapy.

Radiological Assessment Survey of the Vance road Facility Source Vault Building Materials, Oak Ridge Institute for Science and Education, Oak Ridge, Tennessee

International Nuclear Information System (INIS)

Morton, J. R.

2000-01-01

From the 1950s, the Vance Road laboratory was the site of extensive nuclear medical research and involved the used of numerous radionuclides. These nuclides were stored in a source vault stored on the first floor of the facility. Nuclear medical research is no longer conducted in this facility, and the source vault was remediated in preparation for converting the area to office space and general use. The Environmental Survey and Site Assessment Program (ESSAP) of ORISE performed a radiological assessment survey of the source vault and its associated miscellaneous building materials and laboratory equipment in preparation for the conversion to general use space

Directory of cyclotrons used for radionuclide production in Member States

International Nuclear Information System (INIS)

1998-03-01

The directory of cyclotrons used for radionuclide production is an update of the data base on cyclotrons that was compiled in 1983 by the International Atomic Energy Agency. The directory contains technical, utilization and administrative information supplied to the IAEA as of October 1997. The directory was prepared through information collected by questionnaires sent to institutions that either have a cyclotron, or that were identified to be in the process of installation of a cyclotron. The directory contains 206 entries for cyclotrons operating in 34 Member States. The largest concentration of cyclotrons for radionuclide production are located in the United States of America (66), Japan (33) and Germany (22). The largest number of cyclotrons for a single country is the United States of America. The expansion in number of cyclotrons during the last decade has been driven by the advent of advances in medical imaging instrumentation (PET, SPET and more recently 511 KeV emission tomography); introduction of user friendly compact medical cyclotrons from several companies that manufacture cyclotrons; and recent decisions that 15 O-oxygen PET studies in Japan, and 18 F-FDG PET studies in Germany are eligible for reimbursement by government or insurance companies

Directory of cyclotrons used for radionuclide production in Member States

Energy Technology Data Exchange (ETDEWEB)

NONE

1998-03-01

The directory of cyclotrons used for radionuclide production is an update of the data base on cyclotrons that was compiled in 1983 by the International Atomic Energy Agency. The directory contains technical, utilization and administrative information supplied to the IAEA as of October 1997. The directory was prepared through information collected by questionnaires sent to institutions that either have a cyclotron, or that were identified to be in the process of installation of a cyclotron. The directory contains 206 entries for cyclotrons operating in 34 Member States. The largest concentration of cyclotrons for radionuclide production are located in the United States of America (66), Japan (33) and Germany (22). The largest number of cyclotrons for a single country is the United States of America. The expansion in number of cyclotrons during the last decade has been driven by the advent of advances in medical imaging instrumentation (PET, SPET and more recently 511 KeV emission tomography); introduction of user friendly compact medical cyclotrons from several companies that manufacture cyclotrons; and recent decisions that {sup 15}O-oxygen PET studies in Japan, and {sup 18}F-FDG PET studies in Germany are eligible for reimbursement by government or insurance companies.

How cyclotrons work

International Nuclear Information System (INIS)

Nolan, D.

1992-01-01

The operating principles of a cyclic accelerator are presented based on the IBA Cyclone 30 negative ion cyclotron, selected for the Australia's first medical cyclotron. Its main features are: acceleration with variable energy of between 15-30 million electron volts, the capability of extracting two beams simultaneously, low power consumption, easy maintenance. Other aspects not directly related to the principle of operation discussed include the vacuum and the radio-frequency systems as well as the complex computerized control system used to automatically control start-up and shut-down operations. ills

Grouting of nuclear waste vault shafts

International Nuclear Information System (INIS)

Gyenge, M.

1980-01-01

A nuclear waste vault must be designed and built to ensure adequate isolation of the nuclear wastes from human contact. Consequently, after a vault has been fully loaded it must be adequately sealed off to prevent radionuclide migration which may be provided by circulating ground water. Of particular concern in vault sealing are the physical and chemical properties of the sealing materials its long-term durability and stability and the techniques used for its emplacement. Present grouting technology and grout material are reviewed in terms of the particular needs of shaft grouting. Areas requiring research and development are indicated

Survey on radionuclide producing using cyclotron method in Malaysia

International Nuclear Information System (INIS)

Mohd Fadli Mohammad Noh

2008-01-01

This research discuss about basic design and systems of medical cyclotron that Malaysia currently have, its applications in radionuclide production and upcoming technologies of cyclotron. Surveys have been carried out on cyclotron facilities at Hospital Putrajaya and Wijaya International Medical Center, WIMC as well as reactor facility at Malaysia Nuclear Agency. The sources in this research also involves on-line and library searches. Information obtained are recorded, categorized, synthesized and discussed. systems of cyclotron of Hospital Putrajaya are further discussed in details. Based from the surveys carried out, it is found out that cyclotron facilities both in Hospital Putrajaya and WIMC only produce ( 18 F)FDG with radioactivity of 18 F produced in 2007 are 16479 mCi and 92546 mCi respectively. Survey also revealed that radioisotope production at Nuclear Malaysia has had its operation been ceased. A new radiopharmaceutical, namely CHOL is suggested to be synthesized by both facilities as a new PET tracer. Latest developments concerning technologies of cyclotron as well as other accelerators such as laser for future medical accelerator, prospect of boron neutron capture and the potential of hadron therapy in Malaysia are discussed here. Radioisotope production in Malaysia is expected to keep booming in future due to increase in usage of PET techniques and the construction of more compact, easy to handle and less costly cyclotrons. (author)

New superconducting cyclotron driven scanning proton therapy systems

International Nuclear Information System (INIS)

Klein, Hans-Udo; Baumgarten, Christian; Geisler, Andreas; Heese, Juergen; Hobl, Achim; Krischel, Detlef; Schillo, Michael; Schmidt, Stefan; Timmer, Jan

2005-01-01

Since one and a half decades ACCEL is investing in development and engineering of state of the art particle-therapy systems. A new medical superconducting 250 MeV proton cyclotron with special focus on the present and future beam requirements of fast scanning treatment systems has been designed. The first new ACCEL medical proton cyclotron is under commissioning at PSI for their PROSCAN proton therapy facility having undergone successful factory tests especially of the closed loop cryomagnetic system. The second cyclotron is part of ACCEL's integrated proton therapy system for Europe's first clinical center, RPTC in Munich. The cyclotron, the energy selection system, the beamline as well as the four gantries and patient positioners have been installed. The scanning system and major parts of the control software have already been tested. We will report on the concept of ACCEL's superconducting cyclotron driven scanning proton therapy systems and the current status of the commissioning work at PSI and RPTC

Radiological air quality in a depleted uranium (DU) storage vault

International Nuclear Information System (INIS)

Robinson, T.; Cucchiara, A.L.

1999-01-01

The radiological air quality of two storage vaults, one with depleted uranium (DU) and one without, was evaluated and compared. The intent of the study was to determine if the presence of stored DU would significantly contribute to the gaseous/airborne radiation level compared to natural background. Both vaults are constructed out of concrete and are dimensionally similar. The vaults are located on the first floor of the same building. Neither vault has air supply or air exhaust. The doors to both vaults remained closed during the evaluation period, except for brief and infrequent access by the operational group. One vault contained 700 KG of depleted uranium, and the other vault contained documents inside of file cabinets. Radon detectors and giraffe air samplers were used to gather data on the quantity of gaseous/airborne radionuclides in both vaults. The results of this study indicated that there was no significant difference in the quantity of gaseous/airborne radionuclides in the two vaults. This paper gives a discussion of the effects of the stored DU on the air quality, and poses several theories supporting the results

Filigree Vaults

DEFF Research Database (Denmark)

2017-01-01

Filigree Vaults takes its point of departure in the use of ceramics in architecture.Today ceramic is in buildings mostly used as uniform modular elements for surface application - bricks and tiles. This project discusses and exemplifies new possibilities for ceramics in architecture, which emerge...

Commissioning of the Main Magnet of Kolkata K-500 Superconducting Cyclotron

CERN Document Server

Bhandari, Rakesh K

2005-01-01

Main magnet of the K-500 superconducting cyclotron at Kolkata has been fully assembled in the cyclotron vault. The assembly includes alpha and beta superconducting coils inside the liquid helium chamber, coil tank for the outer vacuum, liquid nitrogen shield, support links, cryogenic instrumentation and 80 ton magnet frame forming the pill box structure. Cooling of the coils was started in mid-December. It took about three weeks to fill the liquid helium chamber - fully immersing the coils. All the four temperature sensors embedded in the coil are steady at about 4.4K. At this time the liquid nitrogen line for cooling the shield seems to show a leak. So, we are not cooling the shield. The helium liquefier/regrigerator of 200W capacity has been functioning well and so is the network of vacuum jacketted and liquid nitrogen cooled cryogenic transfer lines. Energization of the main magnet will begin soon. Magnetic field measurement set up is in place to start the mapping. In this presentation, our experiences wit...

Sea urchin vault structure, composition, and differential localization during development

Directory of Open Access Journals (Sweden)

Dickey-Sims Carrie

2005-02-01

Full Text Available Abstract Background Vaults are intriguing ribonucleoprotein assemblies with an unknown function that are conserved among higher eukaryotes. The Pacific coast sea urchin, Strongylocentrotus purpuratus, is an invertebrate model organism that is evolutionarily closer to humans than Drosophila and C. elegans, neither of which possesses vaults. Here we compare the structures of sea urchin and mammalian vaults and analyze the subcellular distribution of vaults during sea urchin embryogenesis. Results The sequence of the sea urchin major vault protein (MVP was assembled from expressed sequence tags and genome traces, and the predicted protein was found to have 64% identity and 81% similarity to rat MVP. Sea urchin MVP includes seven ~50 residue repeats in the N-terminal half of the protein and a predicted coiled coil domain in the C-terminus, as does rat MVP. A cryoelectron microscopy (cryoEM reconstruction of isolated sea urchin vaults reveals the assembly to have a barrel-shaped external structure that is nearly identical to the rat vault structure. Analysis of the molecular composition of the sea urchin vault indicates that it contains components that may be homologs of the mammalian vault RNA component (vRNA and protein components (VPARP and TEP1. The sea urchin vault appears to have additional protein components in the molecular weight range of 14–55 kDa that might correspond to molecular contents. Confocal experiments indicate a dramatic relocalization of MVP from the cytoplasm to the nucleus during sea urchin embryogenesis. Conclusions These results are suggestive of a role for the vault in delivering macromolecules to the nucleus during development.

Research and investigation on medical usage of cyclotrons as a special research project

International Nuclear Information System (INIS)

1980-01-01

In the National Institute of Radiological Sciences, the special research project ''Research and investigation on the medical usage of cyclotrons'' had been carried out in the three years program from fiscal 1976 to 1978. Its purpose was to establish the methods of therapy using particle beam such as fast neutrons and the methods of diagnosis using short-lived radioisotopes and positron-emitting radioisotopes. The works were conducted comprehensively in cooperation of the personnel both in and outside the NIRS. Consequently, the purpose was able to be fulfilled satisfactorily. Following on this project, a new special research project ''Research and investigation on the medical usage of particle accelerators'' was started in fiscal 1979. These results are described on the effects of the therapy, diagnostic utilizations, and the medical usage of heavy ion accelerators. (J.P.N.)

Advances in superconducting cyclotrons at MSU

International Nuclear Information System (INIS)

Blosser, H.; Antaya, T.; Au, R.

1987-01-01

Intensive work on superconducting cyclotrons began at MSU in late 1973 (a brief earlier study had occurred in the early 1960's) and continues vigorously at present. One large cyclotron, the ''K500'', has been operating for a number of years, a second, the ''K800'', is nearing completion, the first operating tests of its magnet having occurred at the time of the previous conference, and a third, the ''medical cyclotron'', is now also nearing completion with first operation of its magnet expected just after the present conference. These cyclotrons like other superconducting cyclotrons are all dramatically smaller than comparable room temperature machines; overall weight is typically about 1/20th of that of room temperature cyclotrons of the same energy. This large reduction in the quantities of materials is partially offset by added complexity, but finally, a net overall cost savings of 50 to 70 % typically results; as a consequence the superconducting cyclotron is widely viewed as the cyclotron of the future. The thirteen years of experience at MSU involving three of these cyclotrons, together with much important work at other laboratories, gives a rather clear view of the advantages and disadvantages of various design approaches including by now a rather significant period of long term evaluation. This paper reviews highlights of this program. (author)

Medical isotope production experience at the V.G. Khlopin Radium Institute cyclotron

International Nuclear Information System (INIS)

Solin, L.M.

2000-01-01

Radium Institute cyclotron MGC-20 is used since 1990. There are four cyclotrons of such type in Russia and four abroad: in Finland, in Hungary, in North Korea and in Egypt. The Radium institute cyclotron was used in different fields, such as radioisotope production, nuclear physics, physics and engineering. For ten years some improvements of the Radium Institute cyclotron operation have been made. Those are: creation of the automatic control system based on IBM PC, development of a new power supply for the ion source, creation of the deflector electronic protection from discharges, change of the main elements of the cyclotron with high induced radioactivity. Moreover we investigated the possibility of the negative ions acceleration at the MGC-20 cyclotron without ion source exchange. The maximum value of the proton beam current reached was about 30 μA for 10 MeV H - beam energy. To extract the proton beam from the cyclotron after the stripping foil we made an additional output beam line. It was used for determination of the horizontal and vertical emittance. A special device was constructed and used for measurements of emittance. The latter amounted 30 π mm mrad for horizontal direction and 16 π mm mrad for vertical direction

Dynamic research of masonry vault in a technical scale

Science.gov (United States)

Golebiewski, Michal; Lubowiecka, Izabela; Kujawa, Marcin

2017-03-01

The paper presents preliminary results of dynamic tests of the masonry barrel vault in a technical scale. Experimental studies are intended to identify material properties of homogenized masonry vaults under dynamic loads. The aim of the work is to create numerical models to analyse vault's dynamic response to dynamic loads in a simplest and accurate way. The process of building the vault in a technical scale is presented in the paper. Furthermore a excitation of vibrations with an electrodynamic modal exciter placed on the vault, controlled by an arbitrary waveform function generator, is discussed. Finally paper presents trends in the research for homogenization algorithm enabling dynamic analysis of masonry vaults. Experimental results were compared with outcomes of so-called macromodels (macromodel of a brick masonry is a model in which masonry, i.e. a medium consisting of two different fractions - bricks and mortar, is represented by a homogenized, uniformed, material). Homogenization entail significant simplifications, nevertheless according to the authors, can be a useful approach in a static and dynamic analysis of masonry structures.

Expression of the Major Vault Protein (MVP) and Cellular Vault Particles in Fish.

Science.gov (United States)

Margiotta, Alyssa L; Bain, Lisa J; Rice, Charles D

2017-11-01

Cellular vaults are ubiquitous 13 mega Da multi-subunit ribonuceloprotein particles that may have a role in nucleocytoplasmic transport. Seventy percent of the vault's mass consists of a ≈100 kDa protein, the major vault protein (MVP). In humans, a drug resistance-associated protein, originally identified as lung resistance protein in metastatic lung cancer, was ultimately shown to be the previously described MVP. In this study, a partial MVP sequence was cloned from channel catfish. Recombinant MVP (rMVP) was used to generate a monoclonal antibody that recognizes full length protein in distantly related fish species, as well as mice. MVP is expressed in fish spleen, liver, anterior kidney, renal kidney, and gills, with a consistent expression in epithelial cells, macrophages, or endothelium at the interface of the tissue and environment or vasculature. We show that vaults are distributed throughout cells of fish lymphoid cells, with nuclear and plasma membrane aggregations in some cells. Protein expression studies were extended to liver neoplastic lesions in Atlantic killifish collected in situ at the Atlantic Wood USA-EPA superfund site on the southern branch of the Elizabeth River, VA. MVP is highly expressed in these lesions, with intense staining at the nuclear membrane, similar to what is known about MVP expression in human liver neoplasia. Additionally, MVP mRNA expression was quantified in channel catfish ovarian cell line following treatment with different classes of pharmacological agents. Notably, mRNA expression is induced by ethidium bromide, which damages DNA. Anat Rec, 2017. © 2017 Wiley Periodicals, Inc. Anat Rec, 300:1981-1992, 2017. © 2017 Wiley Periodicals, Inc. © 2017 Wiley Periodicals, Inc.

Proposed full automatic control system for the Medical Small Cyclotron C-30 at the Institute of Nuclear Studies, Poland

International Nuclear Information System (INIS)

Jankowski, A.

1987-01-01

The computer control system for the C-30 Medical Small Cyclotron, which is currently under construction at the Institute of Nuclear Studies will be presented. The features of this simple and secure system are briefly discussed. Some efforts have been done to make a conversational system easily understandable for operators. The keystone of the control system is an fibre optical link (wireless) between the cyclotron and the computer. The control system is based on the use of an extended configuration of the IBM PC/AT computer. A new system software is used to execute multitask hierarchical programs to control the cyclotron. The comercial adapters for control and data aquisition, connected with the fibre optic communication channels are used to transmit data and control codes. Two colour graphic CRT displays the ongoing status and function of each controlled units so that the operator can monitor the whole system conditions at a glance. The paper gives a general description of the programs which are executed on the computer. It also shows how the cyclotron is controlled by dedicated computer practically without special electronic equipment except of the hardware safety cutout switch. The cyclotron is protected against operating incidents and mistakes by a complex system of interlocks. (author)

JSW's baby cyclotron

International Nuclear Information System (INIS)

Toda, Y.; Kaneda, Y.; Satoh, Y.; Suzukawa, I.; Yamada, T.

1983-01-01

Designed by The Japan Steel Works, Ltd., specially for installation in a hospital's medical department and nuclear research laboratory, '' JSW BABY CYCLOTRON '' has been developed to produce short-lived radioisotopes such as 11C, 13N, 15O and 18F. JSW's Baby Cyclotron has some design features. 1) Fixed energy and four sector azimuthally varying field. 2) Compact figure desired for hospital's nuclear medical department 3) A bitter type magnet yoke shielding activity 4) Simple control and operation 5) Easy maintenance without skilled personnel. Type BC105 (P:10MeV, d:5MeV), BC107 (P:10MeV, d:7MeV), BC168 (P:16MeV, d:8MeV) and BC1710 (P:17MeV, d:10MeV) are available according to required amount of radioisotopes. In our radioisotope production test, yield and purity of 11C, 13N, 15O and 18F are usable to clinical diagnosis

Cyclotron produced radiopharmaceuticals

International Nuclear Information System (INIS)

Kopicka, K.; Fiser, M.; Hradilek, P.; Hanc, P.; Lebeda, O.

2003-01-01

Some of the cyclotron-produced radionuclides may serve as important materials for the production of radiopharmaceuticals. This lecture deals with basic information relating to various aspects of these compounds. In comparison with radionuclides /compounds used for non-medical purposes, radiopharmaceuticals are subject to a broader scale of regulations, both from the safety and efficacy point of view; besides that, there are both radioactive and medical aspects that must be taken into account for any radiopharmaceutical. According to the regulations and in compliance with general rules of work with radioactivity, radiopharmaceuticals should only be prepared/manufactured under special conditions, using special areas and special equipment and applying special procedures (e.g. sterilisation, disinfection, aseptic work). Also, there are special procedures for cleaning and maintenance. Sometimes the requirements for the product safety clash with those for the safety of the personnel; several examples of solutions pertaining to these cases are given in the lecture. Also, the specific role of cyclotron radiopharmaceuticals is discussed. (author)

H-superconducting cyclotron for PET isotope production

International Nuclear Information System (INIS)

Smirnov, V.L.; Vorozhtsov, S.B.; Vincent, J.

2014-01-01

The scientific design of a 14-MeV H - compact superconducting cyclotron for producing of the 18 F and 13 N isotopes has been developed. Main requirements to the facility as a medical accelerator are met in the design. In particular, the main requirement for the cyclotron was the smallest possible size due to the superconducting magnet. The calculations show that the proposed cyclotron allows extracted beam intensity over 500 μA. To increase system reliability and production rates, an external H - ion source is applied. The choice of the cyclotron concept, design of the structure elements, calculation of the electromagnetic fields and beam dynamics from the ion source to the extraction system were performed.

General aspects of meteorology and wind flow patterns at the National Medical Cyclotron site, Camperdown, NSW, Australia

International Nuclear Information System (INIS)

Clark, G.H.; Bartsch, F.J.K.

1994-06-01

As part of an assessment into the consequences of a potential accident at the National Medical Cyclotron, Camperdown, NSW., Australia, two meteorological stations were installed to monitor the winds, temperatures and atmospheric dispersion conditions. The data will be used to assess environmental impacts of the Cyclotron's operation. In spite of the relatively poor performance of the stations, the wind data indicated significant effects of local buildings and the general urban surface roughness features. The prevailing winds during the study were from the north-north-west at night and south-south-west or north-east sea breezes during the day. Atmospheric stability/dispersion categories were typical of an urban heat island location. 11 refs., 10 tabs, 6 figs

Structural and seismic analyses of waste facility reinforced concrete storage vaults

International Nuclear Information System (INIS)

Wang, C.Y.

1995-01-01

Facility 317 of Argonne National Laboratory consists of several reinforced concrete waste storage vaults designed and constructed in the late 1940's through the early 1960's. In this paper, structural analyses of these concrete vaults subjected to various natural hazards are described, emphasizing the northwest shallow vault. The natural phenomenon hazards considered include both earthquakes and tornados. Because these vaults are deeply embedded in the soil, the SASSI (System Analysis of Soil-Structure Interaction) code was utilized for the seismic calculations. The ultimate strength method was used to analyze the reinforced concrete structures. In all studies, moment and shear strengths at critical locations of the storage vaults were evaluated. Results of the structural analyses show that almost all the waste storage vaults meet the code requirements according to ACI 349--85. These vaults also satisfy the performance goal such that confinement of hazardous materials is maintained and functioning of the facility is not interrupted

309 plutonium recycle test reactor ion exchanger vault deactivitation report

International Nuclear Information System (INIS)

Griffin, P.W.

1996-03-01

This report documents the deactivation of the ion exchanger vault at the 309 Plutonium Recycle Test Reactor (PRTR) Facility in the 300 Area. The vault deactivation began in May 1995 and was completed in June 1995. The final site restoration and shipment of the low-level waste for disposal was finished in September 1995. The ion exchanger vault deactivation project involved the removal and disposal of twelve ion exchangers and decontaminating and fixing of residual smearable contamination on the ion exchanger vault concrete surfaces

Computational Fluid Dynamics Model for Saltstone Vault 4 Vapor Space

International Nuclear Information System (INIS)

Lee, Si Young

2005-01-01

Computational fluid dynamics (CFD) methods have been used to estimate the flow patterns for vapor space inside the Saltstone Vault No.4 under different operating scenarios. The purpose of this work is to examine the gas motions inside the vapor space under the current vault configurations. A CFD model took three-dimensional transient momentum-energy coupled approach for the vapor space domain of the vault. The modeling calculations were based on prototypic vault geometry and expected normal operating conditions as defined by Waste Solidification Engineering. The modeling analysis was focused on the air flow patterns near the ventilated corner zones of the vapor space inside the Saltstone vault. The turbulence behavior and natural convection mechanism used in the present model were benchmarked against the literature information and theoretical results. The verified model was applied to the Saltstone vault geometry for the transient assessment of the air flow patterns inside the vapor space of the vault region using the boundary conditions as provided by the customer. The present model considered two cases for the estimations of the flow patterns within the vapor space. One is the reference baseline case. The other is for the negative temperature gradient between the roof inner and top grout surface temperatures intended for the potential bounding condition. The flow patterns of the vapor space calculated by the CFD model demonstrate that the ambient air comes into the vapor space of the vault through the lower-end ventilation hole, and it gets heated up by the Benard-cell type circulation before leaving the vault via the higher-end ventilation hole. The calculated results are consistent with the literature information

Recent development and progress of IBA cyclotrons

Energy Technology Data Exchange (ETDEWEB)

Kleeven, W., E-mail: Willem.Kleeven@iba-group.com [Ion Beam Applications s.a. Chemin du Cyclotron 3, Louvain-la-Neuve (Belgium); Abs, M., E-mail: Michel.Abs@iba-group.com [Ion Beam Applications s.a. Chemin du Cyclotron 3, Louvain-la-Neuve (Belgium); Delvaux, J.L., E-mail: Jean-Luc.Delvaux@iba-group.com [Ion Beam Applications s.a. Chemin du Cyclotron 3, Louvain-la-Neuve (Belgium); Forton, E., E-mail: Eric.Forton@iba-group.com [Ion Beam Applications s.a. Chemin du Cyclotron 3, Louvain-la-Neuve (Belgium); Jongen, Y., E-mail: Yves.Jongen@iba-group.com [Ion Beam Applications s.a. Chemin du Cyclotron 3, Louvain-la-Neuve (Belgium); Medeiros Romao, L., E-mail: Luis.MedeirosRomao@iba-group.com [Ion Beam Applications s.a. Chemin du Cyclotron 3, Louvain-la-Neuve (Belgium); Nactergal, B., E-mail: Benoit.Nactergal@iba-group.com [Ion Beam Applications s.a. Chemin du Cyclotron 3, Louvain-la-Neuve (Belgium); Nuttens, V., E-mail: Vincent.Nuttens@iba-group.com [Ion Beam Applications s.a. Chemin du Cyclotron 3, Louvain-la-Neuve (Belgium); Servais, T., E-mail: Thomas.Servais@iba-group.com [Ion Beam Applications s.a. Chemin du Cyclotron 3, Louvain-la-Neuve (Belgium); Vanderlinden, T., E-mail: Thierry.Vanderlinden@iba-group.com [Ion Beam Applications s.a. Chemin du Cyclotron 3, Louvain-la-Neuve (Belgium); Zaremba, S., E-mail: Simon.Zaremba@iba-group.com [Ion Beam Applications s.a. Chemin du Cyclotron 3, Louvain-la-Neuve (Belgium)

2011-12-15

Several cyclotron development projects were recently realized by Ion Beam Applications S.A. (IBA). This contribution presents three of them: (i) the intensity enhancement of the Cyclone 30 cyclotron, a machine mainly used for the production of SPECT isotopes. This project is related with the increased demand for {sup 201}Tl because of the shortage of Mo/Tc generators from nuclear reactors, (ii) development of a new versatile multiple-particle K = 30 isotope-production cyclotron (the Cyclone 30XP) being able to accelerate H{sup -}, D{sup -} and also {alpha}-particles. The {alpha}-beam of this cyclotron will allow the production of new therapeutic isotopes (e.g. {sup 211}At) and (iii) commissioning of the Cyclone 70 cyclotron installed for Arronax in France. This machine is similar to the C30XP but provides higher energy (K = 70) and allows research on new types of medical isotopes.

Efflux kinetics and intracellular distribution of daunorubicin are not affected by major vault protein/lung resistance-related protein (vault) expression.

NARCIS (Netherlands)

Zon, van A; Mossink, MH; Schoester, M.; Scheper, R.J.; Sonneveld, P.; Wiemer, EA

2004-01-01

Vaults may contribute to multidrug resistance by transporting drugs away from their subcellular targets. To study the involvement of vaults in the extrusion of anthracyclines from the nucleus, we investigated the handling of daunorubicin by drug-sensitive and drug-resistant non-small lung cancer

Manufacturing on the radiopharmaceuticals produced by cyclotron

International Nuclear Information System (INIS)

Ueda, Nobuo

1994-01-01

Radiopharmaceutical (RP) produced by cyclotrons are widely used for the in vivo diagnosis of various diseases such as cancer, cerebral vascular disorders and cardiac diseases. The nuclides used as RPs and their nuclear reactions, and the quantity of RPs supplied in Japan in the last five years are shown. These RPs are delivered to about 1,100 hospitals in Japan. Thallium-201 and iodine-123 showed very high growth rate. Recently, two new I-123 RPs, BMIPP and MIBG which are heart-imaging agents, have been supplied. It suggests that the quantity of I-123 will increase much more in future. The image diagnostic method using RPs is called in vivo nuclear medicine, and has become the indispensable means for medical institutions together with X-ray CT, nuclear magnetic resonance imaging and ultrasonic diagnosis. The RPs for in vivo diagnosis generally used at present are classified into those labeled with the RIs produced with cyclotrons and those labeled with Tc-99m formed by the decay of Mo-99. The quantity being used is overwhelmingly more in the latter, but the former shows the tendency of growth. The commercial production of cyclotron RIs for medical use, the chemical forms and the diagnostic purposes of the RPs using cyclotron RIs, and the state of use of the cyclotron-produced RPs are reported. (K.I.)

Vault Nanoparticles Packaged with Enzymes as an Efficient Pollutant Biodegradation Technology.

Science.gov (United States)

Wang, Meng; Abad, Danny; Kickhoefer, Valerie A; Rome, Leonard H; Mahendra, Shaily

2015-11-24

Vault nanoparticles packaged with enzymes were synthesized as agents for efficiently degrading environmental contaminants. Enzymatic biodegradation is an attractive technology for in situ cleanup of contaminated environments because enzyme-catalyzed reactions are not constrained by nutrient requirements for microbial growth and often have higher biodegradation rates. However, the limited stability of extracellular enzymes remains a major challenge for practical applications. Encapsulation is a recognized method to enhance enzymatic stability, but it can increase substrate diffusion resistance, lower catalytic rates, and increase the apparent half-saturation constants. Here, we report an effective approach for boosting enzymatic stability by single-step packaging into vault nanoparticles. With hollow core structures, assembled vault nanoparticles can simultaneously contain multiple enzymes. Manganese peroxidase (MnP), which is widely used in biodegradation of organic contaminants, was chosen as a model enzyme in the present study. MnP was incorporated into vaults via fusion to a packaging domain called INT, which strongly interacts with vaults' interior surface. MnP fused to INT and vaults packaged with the MnP-INT fusion protein maintained peroxidase activity. Furthermore, MnP-INT packaged in vaults displayed stability significantly higher than that of free MnP-INT, with slightly increased Km value. Additionally, vault-packaged MnP-INT exhibited 3 times higher phenol biodegradation in 24 h than did unpackaged MnP-INT. These results indicate that the packaging of MnP enzymes in vault nanoparticles extends their stability without compromising catalytic activity. This research will serve as the foundation for the development of efficient and sustainable vault-based bioremediation approaches for removing multiple contaminants from drinking water and groundwater.

Recent achievements in Tc-99m radiopharmaceutical direct production by medical cyclotrons.

Science.gov (United States)

Boschi, Alessandra; Martini, Petra; Pasquali, Micol; Uccelli, Licia

2017-09-01

99m Tc is the most commonly used radionuclide in the field of diagnostic imaging, a noninvasive method intended to diagnose a disease, assess the disease state and monitor the effects of treatments. Annually, the use of 99m Tc, covers about 85% of nuclear medicine applications. This isotope releases gamma rays at about the same wavelength as conventional X-ray diagnostic equipment, and owing to its short half-life (t ½  = 6 h) is ideal for diagnostic nuclear imaging. A patient can be injected with a small amount of 99m Tc and within 24 h almost 94% of the injected radionuclide would have decayed and left the body, limiting the patient's radiation exposure. 99m Tc is usually supplied to hospitals through a 99 Mo/ 99m Tc radionuclide generator system where it is produced from the β decay of the parent nuclide 99 Mo (t ½  = 66 h), which is produced in nuclear reactors via neutron fission. Recently, the interruption of the global supply chain of reactor-produced 99 Mo, has forced the scientific community to investigate alternative production routes for 99m Tc. One solution was to consider cyclotron-based methods as potential replacement of reactor-based technology and the nuclear reaction 100 Mo(p,2n) 99m Tc emerged as the most worthwhile approach. This review reports some achievements about 99m Tc produced by medical cyclotrons. In particular, the available technologies for target design, the most efficient extraction and separation procedure developed for the purification of 99m Tc from the irradiated targets, the preparation of high purity 99m Tc radiopharmaceuticals and the first clinical studies carried out with cyclotron produced 99m Tc are described.

Rupture Loop Annex (RLA) ion exchange vault entry and characterization

International Nuclear Information System (INIS)

Ham, J.E.

1996-01-01

This engineering report documents the entry and characterization of the Rupture Loop Annex Ion Exchange (RLAIX) Vault located near the 309 Building's Plutonium Recycle Test Reactor (PRTR). Twelve ion exchange columns were found in the vault. Some of which contained transuranics, Cs 137, and Co 60. The characterization information is necessary for future vault cleanout and column disposal

Cyclotrons at the Institute of Physical and Chemical Research

International Nuclear Information System (INIS)

Imamura, Masashi.

1989-01-01

In this article the destruction by American forces, during World War II, of the Japanese cyclotrons and the subsequent construction of new cyclotrons at the Institute of Physical and Chemical Research, Japan is described. Their use for biological and medical radiation chemistry studies is summarized. (UK)

Diagnostic system for the nuclear medicine with baby cyclotron

International Nuclear Information System (INIS)

Kashihara, Masao; Wakasa, Shyuichiro

1982-01-01

The system of cyclotron nuclear medicine consists of ''RI-production by using the cyclotron'', ''production of radio-pharmaceuticals labeled with RI'', ''positron tomography''. On the other hand, Ultra compact cyclotron (Baby cyclotron) itself, RI production technique and positron tomography have been rapidly developed and advanced. We think that these three functions must be balance in the development in order to spread this system into the routine work in the hospital. However, since the technology of the synthesis for the labeled compounds is not so developed so far, more advance can be strongly expected. In this report, construction of the cyclotron nuclear medicine, utility for the practical use of RI produced by using the cyclotron, technique of RI production, and the studies on automated and efficient productions of radio-pharmaceuticals labeled with short-lived positron emitters for medical diagnostic use are described. (author)

Radiation safety aspects of a 30 MeV proton cyclotron

International Nuclear Information System (INIS)

Nandy, Maitreyee; Bandyopadhyay, Tapas; Sarkar, P.K.; Maiti, Moumita

2005-01-01

High current accelerators are increasingly used in nuclear medicine, power industry, material properties, material damage and astrophysical studies, etc. In the present work we have assessed the direct and transmitted neutron dose, build up and decay of air activity in the vault and soil activity for a 30 MeV 350 μA proton cyclotron. The transmitted dose equivalent H through ordinary concrete shield of different thickness has been estimated using the two different sets of values of the attenuation coefficient T eff . It is observed that while the two sets of H values differ by 25-26%, the required shield thickness is around 2.1 m. in both the cases to bring down the dose to the ICRP specified limit of 1 μSv/hr. Activity induced in the air due to 13 N and 15 O has been estimated. It has been found that for a target vault of 4m.x4m.x4m. dimension the activity concentration goes above the DAC value within a few seconds of commencement of operation even with 12 air changes per hour. A theoretical study of the radioactivity that may be induced in the soil indicates formation of 40 K, 24 Na, 56 Mn, 59 Fe, 27 Mg, 60 Co, 59,63,65 Ni, 64,66 Cu, 65,69 Zn radioisotopes. (author)

Neutron monitoring of plutonium at the ZPPR storage vault

International Nuclear Information System (INIS)

Caldwell, J.T.; Kuckertz, T.H.; Bieri, J.M.; France, S.W.; Goin, R.W.; Hastings, R.D.; Pratt, J.C.; Shunk, E.R.

1981-12-01

We investigated a method for monitoring a typical large storage vault for unauthorized removal of plutonium. The method is based on the assumption that the neutron field in a vault produced by a particular geometric configuration of bulk plutonium remains constant in time and space as long as the configuration is undisturbed. To observe such a neutron field, we installed an array of 25 neutron detectors in the ceiling of a plutonium storage vault at Argonne National Laboratory West. Each neutron detector provided an independent spatial measurement of the vault neutron field. Data collected by each detector were processed to determine whether statistically significant changes had occurred in the neutron field. Continuous observation experiments measured the long-term stability of the system. Removal experiments were performed in which known quantities of plutonium were removed from the vault. Both types of experiments demonstrated that the neutron monitoring system can detect removal or addition of bulk plutonium (11% 240 Pu) whose mass is as small as 0.04% of the total inventory

Radiation monitoring in a self-shielded cyclotron installation

International Nuclear Information System (INIS)

Capaccioli, L.; Gori, C.; Mazzocchi, S.; Spano, G.

2002-01-01

As nuclear medicine is approaching a new era with the spectacular growth of PET diagnosis, the number of medical cyclotrons installed within the major hospitals is increasing accordingly. Therefore modern medical cyclotron are highly engineered and highly reliable apparatus, characterised with reduced accelerating energies (as the major goal is the production of fluorine 18) and often self-shielded. However specific dedicated monitors are still necessary in order to assure the proper radioprotection. At the Careggi University Hospital in Florence a Mini trace 10 MeV self-shielded cyclotron produced by General Electric has been installed in 2000. In a contiguous radiochemistry laboratory, the preparation and quality control of 1 8F DG and other radiopharmaceuticals takes place. Aim of this work is the characterisation and the proper calibration of the above mentioned monitors and control devices

Fibrous dysplasia of the cranial vault: quantitative analysis based on neural networks

International Nuclear Information System (INIS)

Arana, E.; Marti-Bonmati, L.; Paredes, R.; Molla, E.

1998-01-01

To assess the utility of statistical analysis and neural networks in the quantitative analysis of fibrous dysplasia of the cranial vault. Ten patients with fibrous dysplasia (six women and four men with a mean age of 23.60±17.85 years) were selected from a series of 167 patients with lesions of the cranial vault evaluated by plain radiography and computed tomography (CT). Nineteen variables were taken from their medical records and radiological study. Their characterization was based on statistical analysis and neural network, and was validated by means of the leave-one-out method. The performance of the neural network was estimated by means of receiver operating characteristics (ROC) curves, using as a parameter the area under the curve A z . Bivariate analysis identified age, duration of symptoms, lytic and sclerotic patterns, sclerotic margin, ovoid shape, soft-tissue mas and periosteal reaction as significant variables. The area under the neural network curve was 0.9601±0.0435. The network selected the matrix and soft-tissue mass a variables that were indispensable for diagnosis. The neural network presents a high performance in the characterization of fibrous dysplasia of the cranial vault, disclosing occult interactions among the variables. (Author) 24 refs

Experimental Analysis of Dynamic Effects of FRP Reinforced Masonry Vaults

Science.gov (United States)

Corradi, Marco; Borri, Antonio; Castori, Giulio; Coventry, Kathryn

2015-01-01

An increasing interest in the preservation of historic structures has produced a need for new methods for reinforcing curved masonry structures, such as arches and vaults. These structures are generally very ancient, have geometries and materials which are poorly defined and have been exposed to long-term historical movements and actions. Consequently, they are often in need of repair or reinforcement. This article presents the results of an experimental study carried out in the laboratory and during on-site testing to investigate the behaviour of brick masonry vaults under dynamic loading strengthened with FRPs (Fiber Reinforced Polymers). For the laboratory tests, the brick vaults were built with solid sanded clay bricks and weak mortar and were tested under dynamic loading. The experimental tests were designed to facilitate analysis of the dynamic behaviour of undamaged, damaged and reinforced vaulted structures. On-site tests were carried out on an earthquake-damaged thin brick vault of an 18th century aristocratic residence in the city of L’Aquila, Italy. The provision of FRP reinforcement is shown to re-establish elastic behavior previously compromised by time induced damage in the vaults. PMID:28793697

Experimental Analysis of Dynamic Effects of FRP Reinforced Masonry Vaults.

Science.gov (United States)

Corradi, Marco; Borri, Antonio; Castori, Giulio; Coventry, Kathryn

2015-11-27

An increasing interest in the preservation of historic structures has produced a need for new methods for reinforcing curved masonry structures, such as arches and vaults. These structures are generally very ancient, have geometries and materials which are poorly defined and have been exposed to long-term historical movements and actions. Consequently, they are often in need of repair or reinforcement. This article presents the results of an experimental study carried out in the laboratory and during on-site testing to investigate the behaviour of brick masonry vaults under dynamic loading strengthened with FRPs (Fiber Reinforced Polymers). For the laboratory tests, the brick vaults were built with solid sanded clay bricks and weak mortar and were tested under dynamic loading. The experimental tests were designed to facilitate analysis of the dynamic behaviour of undamaged, damaged and reinforced vaulted structures. On-site tests were carried out on an earthquake-damaged thin brick vault of an 18th century aristocratic residence in the city of L'Aquila, Italy. The provision of FRP reinforcement is shown to re-establish elastic behavior previously compromised by time induced damage in the vaults.

Experimental Analysis of Dynamic Effects of FRP Reinforced Masonry Vaults

Directory of Open Access Journals (Sweden)

Marco Corradi

2015-11-01

Full Text Available An increasing interest in the preservation of historic structures has produced a need for new methods for reinforcing curved masonry structures, such as arches and vaults. These structures are generally very ancient, have geometries and materials which are poorly defined and have been exposed to long-term historical movements and actions. Consequently, they are often in need of repair or reinforcement. This article presents the results of an experimental study carried out in the laboratory and during on-site testing to investigate the behaviour of brick masonry vaults under dynamic loading strengthened with FRPs (Fiber Reinforced Polymers. For the laboratory tests, the brick vaults were built with solid sanded clay bricks and weak mortar and were tested under dynamic loading. The experimental tests were designed to facilitate analysis of the dynamic behaviour of undamaged, damaged and reinforced vaulted structures. On-site tests were carried out on an earthquake-damaged thin brick vault of an 18th century aristocratic residence in the city of L’Aquila, Italy. The provision of FRP reinforcement is shown to re-establish elastic behavior previously compromised by time induced damage in the vaults.

An estimation of tritium inventory limits for the E-Area vaults

International Nuclear Information System (INIS)

Yu, A.D.; Cook, J.R.

1991-01-01

At the request of Waste Management, Interim Waste Technology has conducted a modeling study to estimate the tritium inventory limits for the E-Area vaults. These inventory limits are based on the groundwater impact of the planned waste disposal. The tritium inventory limit for an Intermediate Level Tritium Vault (ILTV) is estimated to be 400,000 Curies with a 100 year storage period. During this period, it is assumed that the ILTV will be vented, any leachate will be extracted, and its performance will be carefully monitored. The tritium inventory limits for a Low Activity Waste Vault (LAWV) and an Intermediate Level Non-Tritium Vault (ILNTV) are estimated to be 15,000 and 11,000 Curies, respectively. Venting and leachate extraction were not assumed necessary. These operational alternatives would further enhance the performance of these vaults. These limits are significantly higher than the forecasted maximum tritium inventories for the vaults. Details of the modeling study are described in the attached report

The Effect of the Crystalline Lens on Central Vault After Implantable Collamer Lens Implantation.

Science.gov (United States)

Qi, Meng-Ying; Chen, Qian; Zeng, Qing-Yan

2017-08-01

To identify associations between crystalline lens-related factors and central vault after Implantable Collamer Lens (ICL) (Staar Surgical, Monrovia, CA) implantation. This retrospective clinical study included 320 eyes from 186 patients who underwent ICL implantation surgery. At 1 year after surgery, the central vault was measured using anterior segment optical coherence tomography. Preoperative anterior chamber depth, lens thickness, lens position (lens position = anterior chamber depth + 1/2 lens thickness), and vault were analyzed to investigate the effects of lens-related factors on postoperative vault. The mean vault was 513 ± 215 µm at 1 year after surgery. Vault was positively correlated with preoperative anterior chamber depth (r = 0.495, P lens position (r = 0.371, P lens thickness (r = -0.262, P lens position than eyes in the other two vault groups (which had vaults ≥ 250 µm) (P lens position less than 5.1 mm had greatly reduced vaults (P lens could have an important influence on postoperative vault. Eyes with a shallower anterior chamber and a forward lens position will have lower vaults. [J Refract Surg. 2017;33(8):519-523.]. Copyright 2017, SLACK Incorporated.

Westinghouse Hanford Company special nuclear material vault storage study

International Nuclear Information System (INIS)

Borisch, R.R.

1996-01-01

Category 1 and 2 Special Nuclear Materials (SNM) require storage in vault or vault type rooms as specified in DOE orders 5633.3A and 6430.1A. All category 1 and 2 SNM in dry storage on the Hanford site that is managed by Westinghouse Hanford Co (WHC) is located in the 200 West Area at Plutonium Finishing Plant (PFP) facilities. This document provides current and projected SNM vault inventories in terms of storage space filled and forecasts available space for possible future storage needs

Seismic analysis of the ICPP high level liquid waste tanks and vaults

International Nuclear Information System (INIS)

Uldrich, E.D.; Malik, L.E.

1991-01-01

Two buried, closely spaced, reinforced concrete vaults founded on base rock were evaluated for gravity and safe shutdown earthquake loads. These vaults enclose steel tanks used to store high level radioactive liquid waste. Detailed 3-dimensional finite element models were used for state-of-the-art structure-soil-structure interaction (SSSI) analyses. Three soil dynamic property profiles were used to address soil variability. Vault accelerations are not significantly affected by the variability of soil dynamic properties. Lower bound soil properties yield maximum member forces and moments. Demands on the side closer to the other vault due to horizontal motions are lower due to SSSI effects. Combined gravity and seismic demand on the vault force resisting system was calculated. The vaults were qualified, using member capacities based on current design codes

Exploratory Investigation of Impact Loads During the Forward Handspring Vault

Directory of Open Access Journals (Sweden)

Penitente Gabriella

2015-06-01

Full Text Available The purpose of this study was to examine kinematic and kinetic differences in low and high intensity hand support impact loads during a forward handspring vault. A high-speed video camera (500 Hz and two portable force platforms (500 Hz were installed on the surface of the vault table. Two-dimensional analyses were conducted on 24 forward handspring vaults performed by 12 senior level, junior Olympic program female gymnasts (16.9 ±1.4 yr; body height 1.60 ±0.1 m; body mass 56.7 ±7.8 kg. Load intensities at impact with the vault table were classified as low (peak force 0.8 × body weight. These vaults were compared via crucial kinetic and kinematic variables using independent t-tests and Pearson correlations. Statistically significant (p < 0.001 differences were observed in peak force (t(24 = 4.75, ES = 3.37 and time to peak force (t(24 = 2.07, ES = 1.56. Statistically significant relationships between the loading rate and time to peak force were observed for high intensity loads. Peak force, time to peak force, and a shoulder angle at impact were identified as primary variables potentially involved in the determination of large repetitive loading rates on the forward handspring vault.

Major vault protein in cardiac and smooth muscle.

Science.gov (United States)

Shults, Nataliia V; Das, Dividutta; Suzuki, Yuichiro J

Major vault protein (MVP) is the major component of the vault particle whose functions are not well understood. One proposed function of the vault is to serve as a mechanism of drug transport, which confers drug resistance in cancer cells. We show that MVP can be found in cardiac and smooth muscle. In human airway smooth muscle cells, knocking down MVP was found to cause cell death, suggesting that MVP serves as a cell survival factor. Further, our laboratory found that MVP is S-glutathionylated in response to ligand/receptor-mediated cell signaling. The S-glutathionylation of MVP appears to regulate protein-protein interactions between MVP and a protein called myosin heavy chain 9 (MYH9). Through MYH9 and Vsp34, MVP may form a complex with Beclin-1 that regulates autophagic cell death. In pulmonary vascular smooth muscle, proteasome inhibition promotes the ubiquitination of MVP, which may function as a mechanism of proteasome inhibition-mediated cell death. Investigating the functions and the regulatory mechanisms of MVP and vault particles is an exciting new area of research in cardiovascular/pulmonary pathophysiology.

Radiological performance assessment for the E-Area Vaults Disposal Facility

Energy Technology Data Exchange (ETDEWEB)

Cook, J.R.; Hunt, P.D. [Westinghouse Savannah River Co., Aiken, SC (United States)

1994-04-15

The E-Area Vaults (EAVs) located on a 200 acre site immediately north of the current LLW burial site at Savannah River Site will provide a new disposal and storage site for solid, low-level, non-hazardous radioactive waste. The EAV Disposal Facility will contain several large concrete vaults divided into cells. Three types of structures will house four designated waste types. The Intermediate Level Non-Tritium Vaults will receive waste radiating greater than 200 mR/h at 5 cm from the outer disposal container. The Intermediate Level Tritium Vaults will receive waste with at least 10 Ci of tritium per package. These two vaults share a similar design, are adjacent, share waste handling equipment, and will be closed as one facility. The second type of structure is the Low Activity Waste Vaults which will receive waste radiating less than 200 mR/h at 5 cm from the outer disposal container and containing less than 10 Ci of tritium per package. The third facility, the Long Lived Waste Storage Building, provides covered, long term storage for waste containing long lived isotopes. Two additional types of disposal are proposed: (1) trench disposal of suspect soil, (2) naval reactor component disposal. To evaluate the long-term performance of the EAVs, site-specific conceptual models were developed to consider: (1) exposure pathways and scenarios of potential importance; (2) potential releases from the facility to the environment; (3) effects of degradation of engineered features; (4) transport in the environment; (5) potential doses received from radionuclides of interest in each vault type.

Radiological performance assessment for the E-Area Vaults Disposal Facility

International Nuclear Information System (INIS)

Cook, J.R.; Hunt, P.D.

1994-01-01

The E-Area Vaults (EAVs) located on a 200 acre site immediately north of the current LLW burial site at Savannah River Site will provide a new disposal and storage site for solid, low-level, non-hazardous radioactive waste. The EAV Disposal Facility will contain several large concrete vaults divided into cells. Three types of structures will house four designated waste types. The Intermediate Level Non-Tritium Vaults will receive waste radiating greater than 200 mR/h at 5 cm from the outer disposal container. The Intermediate Level Tritium Vaults will receive waste with at least 10 Ci of tritium per package. These two vaults share a similar design, are adjacent, share waste handling equipment, and will be closed as one facility. The second type of structure is the Low Activity Waste Vaults which will receive waste radiating less than 200 mR/h at 5 cm from the outer disposal container and containing less than 10 Ci of tritium per package. The third facility, the Long Lived Waste Storage Building, provides covered, long term storage for waste containing long lived isotopes. Two additional types of disposal are proposed: (1) trench disposal of suspect soil, (2) naval reactor component disposal. To evaluate the long-term performance of the EAVs, site-specific conceptual models were developed to consider: (1) exposure pathways and scenarios of potential importance; (2) potential releases from the facility to the environment; (3) effects of degradation of engineered features; (4) transport in the environment; (5) potential doses received from radionuclides of interest in each vault type

Mapping genetic variants for cranial vault shape in humans

DEFF Research Database (Denmark)

Roosenboom, Jasmien; Lee, Myoung Keun; Hecht, Jacqueline T

2018-01-01

The shape of the cranial vault, a region comprising interlocking flat bones surrounding the cerebral cortex, varies considerably in humans. Strongly influenced by brain size and shape, cranial vault morphology has both clinical and evolutionary relevance. However, little is known about the geneti...

Development of baby cyclotron for PET in Korea

International Nuclear Information System (INIS)

Chai, J.S.; Kim, Y.S.; Hu, J.Y.; Shin, Y.C.; Yoon, M.H.

2001-01-01

Development of a 13 MeV cyclotron for Positron Emission Tomography (PET) has been in progress since April 1999 at the Korea Cancer Center Hospital (KCCH). The study has been carried out in a joint collaboration between KCCH and the Pohang University of Science and Technology (POSTECH). Increasing desire for an uninterrupted, reliable and timely supply of the isotopes to customers has prompted obtaining a dedicated 5-13 MeV cyclotron for PET applications and pursuing the purchase of another 30MeV medical cyclotron in the very near future. A decision has been made to design the PET cyclotron in Korea. This will not only ease the problems associated with maintenance during operation but also keep the door open for continuous upgrading of the machine in the future

Clinical diagnostic system using a small cyclotron for medical use

International Nuclear Information System (INIS)

Yonekura, Y.; Magata, Y.; Konishi, J.

1990-01-01

Since a small cyclotron and a positron emission tomography (PET) scanner have been installed at the Kyoto University Hospital in 1983, a great deal of effort has been directed to the clinical application of the PET-cyclotron system. This paper outlines the experience with PET in the clinical setting, including the facility, equipments and staff involved, weekly schedule, typical clinical protocols, and some results from the patients. The system consists of small cyclotron for production of the short-lived positron emitting radionuclides, fully automated synthesis system for labeling various compounds, scanning for measurement of radioactivities, and data analysis system for calculating physiological parameters. A resolving cylinder target system with eight smaller cylinders is equipped for production of C-11, N-13, O-15, and F-18. Labeled compounds are quickly delivered to the PET scanner room by two systems--the continuous delivery system for the labeled gas and the rapid delivery system for the liquid compounds by compressed air. A PET scanner devoted for clinical studies is a multislice whole-body PET scanner. Ten PET studies are performed weekly on the average for measuring blood flow and oxygen and glucose metabolism in the brain, blood flow and glucose and fatty acid metabolism in the heart, blood flow and amino acid uptake in the pancreas, lung ventilation, and tumor glucose metabolism. The availability of PET-cyclotron system is still limited in view of cost. The previous clinical studies suggest the contribution of PET to the the understanding of the mechanism of disease pathophysiology. (N.K.)

Thermal analysis of the failed equipment storage vault system

International Nuclear Information System (INIS)

Jerrell, J.; Lee, S.Y.; Shadday, A.

1995-07-01

A storage facility for failed glass melters is required for radioactive operation of the Defense Waste Processing Facility (DWPF). It is currently proposed that the failed melters be stored in the Failed Equipment Storage Vaults (FESV's) in S area. The FESV's are underground reinforced concrete structures constructed in pairs, with adjacent vaults sharing a common wall. A failed melter is to be placed in a steel Melter Storage Box (MSB), sealed, and lowered into the vault. A concrete lid is then placed over the top of the FESV. Two melters will be placed within the FESV/MSB system, separated by the common wall. There is no forced ventilation within the vault so that the melter is passively cooled. Temperature profiles in the Failed Equipment Storage Vault Structures have been generated using the FLOW3D software to model heat conduction and convection within the FESV/MSB system. Due to complexities in modeling radiation with FLOW3D, P/THERMAL software has been used to model radiation using the conduction/convection temperature results from FLOW3D. The final conjugate model includes heat transfer by conduction, convection, and radiation to predict steady-state temperatures. Also, the FLOW3D software has been validated as required by the technical task request

Development of cyclotron solid targetry

International Nuclear Information System (INIS)

D'Souza, J.; Deans, T.; Cryer, D.; Price, R.

2004-01-01

Full text: Western Australia's first medical cyclotron was recently installed in the Department of Medical Technology and Physics at Sir Charles Gairdner Hospital. The cyclotron is routinely used for 18 F production using a liquid target, and now research is being undertaken into solid target bombardment for production of novel isotopes such as 124 I, 64 Cu and 96 Tc. The IBA Cyclone 18/9 has a maximum proton beam energy of 18MeV and maximum beam current of 80μA. A proton beam is generated by the acceleration of H- ions in the evacuated cyclotron (10 -6 bar) which are then stripped of 2 electrons just prior to exiting a target port. Each port has two strippers which are made of 10μm thick carbon with dimensions 12mmxl3mm. Due to their thinness, the strippers are easily ruptured. The Cyclone 18/9 has 8 target ports. In order to fit a target onto the cyclotron when the cyclotron is already evacuated the target is first evacuated to 10 -3 bar by a roughing pump before an isolation valve at the port is opened. This stops any damage that may occur by the flow of air from the target reservoir to the cyclotron eg to the strippers. The first step in the project to develop solid targetry is to build a beam line in order to measure the beam profile. If successful, this design will be improved in order to have a beam line and target holder that are suitable for use in solid target bombardment. A 40cm beam line with an internal diameter of 3.6cm was built to fit onto the IBA Cyclone 18/9. The beam line, made out of aluminium, incorporates a step 5cm from the end at which a target material can be fitted. A cover fits onto the beam line, behind the target in order to maintain vacuum. The cover is held in place by the vacuum within the beam line. At the end of bombardment, the beam line can be isolated from the vacuum of the target and normal air pressure restored. In doing so the cover plate falls open and the target falls into a lead pot, ready for removal from the cyclotron

The problems of high efficient extraction from the isochronous cyclotron

International Nuclear Information System (INIS)

Schwabe, J.

1994-06-01

The problem of high efficient extraction (η ≥ 50%) from isochronous cyclotrons (with the exception of the stripping method) is not completely solved up to this day. This problem is specifically important, because these cyclotrons are being also applied in the production of medical radioisotopes, labeled pharmaceuticals as well as in neutron therapy (oncology), machine industry, agriculture (plant mutagenesis), etc. The aim of the proposed topic is to solve this problem on the AIC-144 isochronous cyclotron in the INP (Institute of Nuclear Physics). Lately, a beam of 20 MeV deuterons with an efficiency of ca. 15% was extracted from this cyclotron. (author). 25 refs, 14 figs

Monitoring and detection of plutonium movement in storage vaults

International Nuclear Information System (INIS)

Kuckertz, T.H.; Bieri, J.M.; Caldwell, J.T.; France, S.W.; Hastings, R.D.; Pratt, J.C.; Shunk, E.R.; Goin, R.W.

1981-01-01

We investigated a method for monitoring a typical large storage vault for unauthorized removal of plutonium. The method is based on the assumption that the neutron field in a vault produced by a particular geometric configuration of bulk plutonium remains constant in time and space as long as the configuration is undisturbed. To observe such a neutron field, we installed an array of 25 3 He proportional counters in the ceiling of a plutonium storage vault at Argonne National Laboratory West. Data collected by each counter were processed to determine whether statistically significant changes had occurred in the neutron field. Continuous observation experiments measured the long-term stability of the system. Removal experiments were performed in which known quantities of plutonium were removed from the vault. Both types of experiments demonstrated that the neutron monitoring system can detect removal or addition of bulk plutonium (11% 240 Pu) whose mass is as small as 0.04% of the total inventory

Thermal Stabilization of Cryogenic System in Superconducting Cyclotron

International Nuclear Information System (INIS)

Shin, Seung Jae; Kim, Kyung Min; Cho, Hyung Hee; Hong, Bong Hwan; Kang, Joon Sun; Ahn, Dong Hyun

2011-01-01

Radiology has some useful applications for medical purpose. For cancer therapy, the superconducting cyclotron should generate heavy ion beams. It radiates heavy ion beams to cancer patients. In order to make cyclotron system stable, the cryogenic system which makes superconducting state should work constantly. However, radiation heat transfer of cryogenic system should be considered because liquid helium's boiling point is extremely low and there is huge temperature difference between the cryogenic system and ambient temperature. Accordingly, thermal analysis should be carried out. In this paper, the numerical analysis of the cryogenic system in practical superconducting cyclotron show temperature distribution and suggest the number of coolers using ANSYS Workbench program

Radionuclide limits for vault disposal at the Savannah River Site

International Nuclear Information System (INIS)

Cook, James R.

1992-01-01

The Savannah River Site is developing a facility called the E-Area Vaults which will serve as the new radioactive waste disposal facility beginning early in 1992. The facility will employ engineered below-grade concrete vaults for disposal and above grade storage for certain long-lived mobile radionuclides. This report documents the determination of interim upper limits for radionuclide inventories and concentrations which should be allowed in the disposal structures. The work presented here will aid in the development of both waste acceptance criteria and operating limits for the E-Area Vaults. Disposal limits for forty isotopes which comprise the SRS waste streams were determined. The limits are based on total facility and vault inventories for those radionuclides which impact groundwater) and on waste package concentrations for those radionuclides which could affect intruders. (author)

An investigation into the technical feasibility of cyclotron production of technetium-99m

International Nuclear Information System (INIS)

Egan, G.F.; Lagunas-Solar, M.C.

1994-01-01

The role of technetium-99m in nuclear medicine is well established with 80 per cent to 90 per cent of all nuclear medicine studies utilising this isotope. Technetium-99m is currently produced from nuclear reactors via production of the parent radionuclide molybdenum-99. The reactor production of 99m Tc has both significant financial and environmental costs, with unresolved problems in the areas of radioactive waste disposal and reactor decommissioning. Recent scientific publications have indicated that medical quality 99m Tc may be produced using cyclotrons without having the associated problems of waste disposal and decommissioning. Further scientific research is now required to demonstrate the feasibility of this cyclotron production technique. A collaboration between the Cyclotron and PET Centre, Austin Hospital, the National Medical Cyclotron, ANSTO, Sydney, and the Crocker Nuclear Laboratory, University of California, Davis, USA has been proposed. The general objective of the proposed collaboration is to acquire additional scientific data to evaluate the 99m Tc cyclotron production method and to determine the feasibility of cyclotron technology for Australian nuclear medicine. 16 refs., 2 tabs

Magnet design and test of positron emission tomography cyclotron

International Nuclear Information System (INIS)

Wei Tao; Yang Guojun; He Xiaozhong; Pang Jian; Zhao Liangchao; Zhang Kaizhi

2012-01-01

An 11 MeV H - compact cyclotron used for medical radioactive isotope production is under construction in Institute of Fluid Physics, CAEP. The cyclotron magnet adopts the design of small valley gaps and coulee structure which can provide high average magnetic field and strong focus ability. To achieve 5 × 10 -4 measuring accuracy, a magnetic field mapping system has been developed. After iterative correction using field measurement data, the total phase excursion of the cyclotron is within ± 9° and the first harmonic is less than 10 -3 T, which are all acceptable. Furthermore, the beam testing declares the successful construction of the cyclotron magnet. Besides, some magnetic field influence factors were discussed, including the magnetic field distortion and measurement error. (authors)

Atmospheric tracer tests and assessment of a potential accident at the National Medical Cyclotron, Camperdown, NSW, Australia

International Nuclear Information System (INIS)

Clark, G.H.; Bartsch, F.J.K.; Stone, D.J.M.

1994-08-01

In order to assess the impact of a potential atmospheric release of radionuclides from the National Medical Cyclotron facility, in Camperdown, an atmospheric tracer release, sampling and analysis system using SF 6 was developed. During eight experiments conducted in a variety of meteorological conditions, ten samplers were located in the vicinity of the Cyclotron building and other nearby buildings on the rapid downward movement of the tracer gas plume. The atmospheric dilution factors which lead to the highest observed air concentrations were then applied to the releases of I 123 and Xe 123 from a potential accident scenario in order to assess the impact on nearby receptors. Even given the conservative assumptions about the release of I 123 , the estimated radiation doses were at least an order of magnitude below the international standards for doses to member of the public. 27 refs., 8 tabs., 5 figs

Atmospheric tracer tests and assessment of a potential accident at the National Medical Cyclotron, Camperdown, NSW, Australia

Energy Technology Data Exchange (ETDEWEB)

Clark, G H; Bartsch, F J.K.; Stone, D J.M.

1994-08-01

In order to assess the impact of a potential atmospheric release of radionuclides from the National Medical Cyclotron facility, in Camperdown, an atmospheric tracer release, sampling and analysis system using SF{sub 6} was developed. During eight experiments conducted in a variety of meteorological conditions, ten samplers were located in the vicinity of the Cyclotron building and other nearby buildings on the rapid downward movement of the tracer gas plume. The atmospheric dilution factors which lead to the highest observed air concentrations were then applied to the releases of I{sup 123} and Xe{sup 123} from a potential accident scenario in order to assess the impact on nearby receptors. Even given the conservative assumptions about the release of I{sup 123}, the estimated radiation doses were at least an order of magnitude below the international standards for doses to member of the public. 27 refs., 8 tabs., 5 figs.

The Midwest Proton Radiation Institute project at the Indiana University Cyclotron Facility

Energy Technology Data Exchange (ETDEWEB)

Anferov, V; Broderick, B; Collins, J C; Friesel, D L; Jenner, D; Jones, W P; Katuin, J; Klein, S B; Starks, W; Self, J; Schreuder, N [IUCF, Bloomington, Indiana 47408 (United States)

2001-12-12

The IUCF cyclotrons ceased delivering particle beams for physics research and became dedicated medical proton beam accelerators in 1999. Removal of the beam lines and nuclear research facilities associated with the cyclotrons to make room for the new medical beam delivery systems was completed in October, 2000. A new achromatic beam line was completed, extending from the main stage cyclotron and ending at a temporary research platform. This beam line is being commissioned during ongoing applied research. The achromatic line will deliver 0.5 {mu}A of 205 MeV protons from which the treatment room technician may draw current at any time via fast switching, laminated magnets located at the entrances to the energy selection systems upstream of each of the treatment rooms. Three treatment rooms are planned, one containing two fixed horizontal lines and two gantry rooms. The cyclotrons will also support full time research in radiation effects, single event upset, radiation biology and pre-clinical research. This contribution describes the status of the medical construction project.

Concept study: Use of grout vaults for disposal of long-length contaminated equipment

International Nuclear Information System (INIS)

Clem, D.K.

1994-01-01

Study considers the potential for use of grout vaults for disposal of untreated long length equipment removed from waste tanks. Looks at ways to access vaults, material handling, regulatory aspects, and advantages and disadvantages of vault disposal

Directory of cyclotrons used for radionuclide production in Member States [2006 update

International Nuclear Information System (INIS)

2006-10-01

The present directory of cyclotron facilities used for the production of radionuclides in Member States is an update of the one compiled by the International Atomic Energy Agency (IAEA) in late 2001 and published in 2002. This directory was prepared through information collected by questionnaires that the IAEA sent to known institutions operating cyclotrons for radionuclide production. Technical as well as administrative data supplied to the IAEA as of November 2005 were taken into account. The directory is considered to include most of the cyclotrons of the world that are used at least partially for radionuclide production. There are 262 entries for cyclotrons operating in 39 Member States of the IAEA. This is an increase of 7% over the 246 reported in the 2002 cyclotron directory. This can be compared to the 350 or so cyclotrons believed to be presently operating in the world, which are involved in some aspects of radionuclide production. The increase has been in the number of cyclotrons in developed countries, but even more so in the developing countries. The increase in number during the last four years was driven by several factors, i.e. advent of advances in medical imaging, introduction of compact, user friendly medical cyclotron, and a recent decision that costs for 15 O-oxygen position emission tomography (PET) studies in Japan and 18 F-FDG PET studies in Germany and the United States of America are eligible for reimbursement by government or health insurance companies. There is no doubt that the fastest growing segment of the market is in the commercial distribution of FDG to local hospitals. The IAEA is promoting cyclotron technology as applied to nuclear medicine. Requests for cyclotron technology is steadily increasing; many developing Member States are interested in this technology. There is need to stimulate, build and maintain consulting capability in interested developing Member States. There are good reasons to believe that the number of cyclotron

Design study of the KIRAMS-430 superconducting cyclotron magnet

International Nuclear Information System (INIS)

Kim, Hyun Wook; Kang, Joonsun; Hong, Bong Hwan; Jung, In Su

2016-01-01

Design study of superconducting cyclotron magnet for the carbon therapy was performed at the Korea Institute of Radiological and Medical Science (KIRAMS). The name of this project is The Korea Heavy Ion Medical Accelerator (KHIMA) project and a fixed frequency cyclotron with four spiral sector magnet was one of the candidate for the accelerator type. Basic parameters of the cyclotron magnet and its characteristics were studied. The isochronous magnetic field which can guide the "1"2C"6"+ ions up to 430 MeV/u was designed and used for the single particle tracking simulation. The isochronous condition of magnetic field was achieved by optimization of sector gap and width along the radius. Operating range of superconducting coil current was calculated and changing of the magnetic field caused by mechanical deformations of yokes was considered. From the result of magnetic field design, structure of the magnet yoke was planned.

Design study of the KIRAMS-430 superconducting cyclotron magnet

Energy Technology Data Exchange (ETDEWEB)

Kim, Hyun Wook; Kang, Joonsun, E-mail: genuinei@kirams.re.kr; Hong, Bong Hwan; Jung, In Su

2016-07-01

Design study of superconducting cyclotron magnet for the carbon therapy was performed at the Korea Institute of Radiological and Medical Science (KIRAMS). The name of this project is The Korea Heavy Ion Medical Accelerator (KHIMA) project and a fixed frequency cyclotron with four spiral sector magnet was one of the candidate for the accelerator type. Basic parameters of the cyclotron magnet and its characteristics were studied. The isochronous magnetic field which can guide the {sup 12}C{sup 6+} ions up to 430 MeV/u was designed and used for the single particle tracking simulation. The isochronous condition of magnetic field was achieved by optimization of sector gap and width along the radius. Operating range of superconducting coil current was calculated and changing of the magnetic field caused by mechanical deformations of yokes was considered. From the result of magnetic field design, structure of the magnet yoke was planned.

An analytical approach of thermodynamic behavior in a gas target system on a medical cyclotron.

Science.gov (United States)

Jahangiri, Pouyan; Zacchia, Nicholas A; Buckley, Ken; Bénard, François; Schaffer, Paul; Martinez, D Mark; Hoehr, Cornelia

2016-01-01

An analytical model has been developed to study the thermo-mechanical behavior of gas targets used to produce medical isotopes, assuming that the system reaches steady-state. It is based on an integral analysis of the mass and energy balance of the gas-target system, the ideal gas law, and the deformation of the foil. The heat transfer coefficients for different target bodies and gases have been calculated. Excellent agreement is observed between experiments performed at TRIUMF's 13 MeV cyclotron and the model. Copyright © 2015 Elsevier Ltd. All rights reserved.

PIXE analysis by baby cyclotron

International Nuclear Information System (INIS)

Yoshida, Hyogo; Tanaka, Teruaki; Ito, Takashi; Toda, Yohjiro; Wakasa, Hideichiro

1988-01-01

The Japan Steel Works, Ltd. has been supplying a very small sized cyclotron (Baby Cyclotron) to hospitals and research facilities. The cyclotron is designed to produce short-lived radioisotopes for medical use. In the present study, this cyclotron is modified so that it can serve for PIXE analysis. The PIXE (particle induced X-ray emission) technique has the following features: (1) Down to 1 ng of trace material in a sample (mg - μg) can be detected, (2) An analysis run is completed in one to ten minutes, permitting economical analysis for a large number of samples, (3) Several elements can be analyzed simultaneously, with an almost constant sensitivity for a variety of elements ranging from aluminum to heavy metals, (4) Analysis can be performed nondestructively without a chemical process, and (5) The use of microbeam can provide data on the distribution of elements with a resolution of several μm. Software for analysis is developed to allow the modified equipment to perform peak search, background fitting, and identification and determination of peaks. A study is now being conducted to examine the performance of the equipment for PIXE analysis of thin samples. Satisfactory results have been obtained. The analysis time, excluding the background correction, is 5-10 min. (Nogami, K.)

Geometric principles in additive systems for construction of vaults

DEFF Research Database (Denmark)

Jaeger, Thomas Arvid

2015-01-01

della Fiore. The Barouque style followed with the domes of Borromini; Bernini and Guarini. The Period of Enlightenment had iconic tunnel- and dome vault projects by Etienne l. Boulée. All these stone vaults were made by additive systems in bricks and mortar. In the 20.th century concrete was introduced...

Vaginal vault recurrences of endometrial cancer in non-irradiated patients

DEFF Research Database (Denmark)

Hardarson, Hordur Alexander; Nyhøj Heidemann, Lene; Christensen, René dePont

2015-01-01

are few and limited to previously irradiated patients or patients with advanced disease. Investigation of surgical treatment for isolated vaginal vault recurrence is practically nonexistent. The aim of this study is to evaluate the efficacy of RT and ST in a non-irradiated group with recurrent endometrial...... cancer limited to the vaginal vault. METHODS: Patients treated for recurrent endometrial cancer at Odense University Hospital, Denmark between 2003 and 2012 were identified, n = 118. Thirty-three patients had an isolated vaginal vault recurrence and were treated with either RT, ST or both. Re...

Radioisotope production in the I. Ph. P. E. cyclotron for medical application

Energy Technology Data Exchange (ETDEWEB)

Krasnov, N.N.; Dmitriyev, P.P.; Konjakhin, N.A.; Ognev, A.A. (Gosudarstvennyj Komitet po Ispol' zovaniyu Atomnoj Ehnergii SSSR, Obninsk. Fiziko-Ehnergeticheskij Inst.)

1982-01-01

The production methods for seven radioisotopes, Ga-67, Sr-85, Pd-103, In-111, Tm-167, Hg-197 and Pb-203, by using a classical 1.5m cyclotron in the Institute of Physics and Power Engineering, Obninsk, USSR, are described. At present, more than 50 cyclotrons in different countries are used for the production of radioisotopes applied to medicine. Radioisotopes are produced with the cyclotron in the I.Ph.P.E. in the form of irradiated targets, which are delivered to Moscow radiopharmaceutical factory, where radiopharmaceuticals are produced on the base of these targets. The cyclotron is operated in two regimes providing the acceleration of protons, deuterons and alpha -particles. Two types of target assemblies are used for irradiation, the one is intended for the internal beam, and the other is for the external beam. The reactions used for the production of seven radioisotopes described above, the types of targets, particle energy, respective irradiated materials, beam current, thick target yield and the amount of respective radioisotopes produced per year are reported. Metals have large heat conductivity, therefore the use of metal targets increases beam current, and increases the production rate of radioisotopes.

Seismic review of vault for MFTF upgrade project

International Nuclear Information System (INIS)

Franklin, H.A.

1983-01-01

This letter report was prepared in accordance with the scope of work for the preconceptual seismic evaluation of the (α + T) Tandem Mirror Fusion Machine concrete vault. The scope of the work was developed with the assistance of the Bechtel site representative Dr. Sunil Ghose. The report contains comments and preconceptual recommendations on wall upgrading for an 150-ton crane installation, concrete vault seismic capability for (α + T) conditions, and recommendations for future work

Modern compact cyclotrons for nuclear medicine designed and manufactured in NIIEFA

International Nuclear Information System (INIS)

Bogdanov, P.V.; Vasilchenko, I.N.; Gavrish, Yu.N.; Galchuk, A.V.; Grigorenko, S.V.; Kuzhlev, A.N.; Menshov, Yu.D.; Mudroyubov, V.G.; Ponomarenko, V.I.; Strokach, A.P.

2012-01-01

A series of compact cyclotrons, the CC-12, CC-18/9 and MCC-30/15, intended for the production of radionuclides for diagnostics and therapy directly in medical institutions has been designed and manufactured in NIIEFA. These cyclotrons provide the acceleration of negative hydrogen and deuterium ions injected from external sources. Beams of accelerated particles are extracted by stripping negative ions to protons and deuterons by carbon foils. Shielding-type electromagnets with the vertically located median plane are applied in these cyclotrons.

Solid targets and irradiation facilities for production of diagnostic and therapeutic radionuclides at the Debrecen cyclotron

International Nuclear Information System (INIS)

Tarkanyi, F.; Ando, L.; Szucs, Z.; Mahunka, I.; Kovacs, Z.

2000-01-01

The MGC-20E (NIIEFA, Leningrad, USSR) variable energy compact cyclotron (k=20) was installed in ATOMKI (Debrecen, Hungary) in 1985. Protons, deuterons, 3 He- and α-particles can be accelerated with currents up to 300 μA for internal irradiation and up to 50 μA for external beams. The establishment of the Cyclotron Laboratory was partly supported by the International Atomic Energy Agency. The application of the cyclotron is multipurpose: basic nuclear research, application of activation technique for analytical and wear studies, application of intense fast neutron source for agro-biological, bio-medical application and for radiation damage test of electronic components, and finally radioisotope production for medical diagnostics and for other scientific and applied fields. The cyclotron laboratory has six target rooms, a radiochemistry laboratory and a medical unit equipped with PET

Performance test of electron cyclotron resonance ion sources for the Hyogo Ion Beam Medical Center

Science.gov (United States)

Sawada, K.; Sawada, J.; Sakata, T.; Uno, K.; Okanishi, K.; Harada, H.; Itano, A.; Higashi, A.; Akagi, T.; Yamada, S.; Noda, K.; Torikoshi, M.; Kitagawa, A.

2000-02-01

Two electron cyclotron resonance (ECR) ion sources were manufactured for the accelerator facility at the Hyogo Ion Beam Medical Center. H2+, He2+, and C4+ were chosen as the accelerating ions because they have the highest charge to mass ratio among ion states which satisfy the required intensity and quality. The sources have the same structure as the 10 GHz ECR source at the Heavy Ion Medical Accelerator in Chiba except for a few improvements in the magnetic structure. Their performance was investigated at the Sumitomo Heavy Industries factory before shipment. The maximum intensity was 1500 μA for H2+, 1320 μA for He2+, and 580 μA for C4+ at the end of the ion source beam transport line. These are several times higher than required. Sufficient performance was also observed in the flatness and long-term stability of the pulsed beams. These test results satisfy the requirements for medical use.

Accurate Monte Carlo modeling of cyclotrons for optimization of shielding and activation calculations in the biomedical field

Science.gov (United States)

Infantino, Angelo; Marengo, Mario; Baschetti, Serafina; Cicoria, Gianfranco; Longo Vaschetto, Vittorio; Lucconi, Giulia; Massucci, Piera; Vichi, Sara; Zagni, Federico; Mostacci, Domiziano

2015-11-01

Biomedical cyclotrons for production of Positron Emission Tomography (PET) radionuclides and radiotherapy with hadrons or ions are widely diffused and established in hospitals as well as in industrial facilities and research sites. Guidelines for site planning and installation, as well as for radiation protection assessment, are given in a number of international documents; however, these well-established guides typically offer analytic methods of calculation of both shielding and materials activation, in approximate or idealized geometry set up. The availability of Monte Carlo codes with accurate and up-to-date libraries for transport and interactions of neutrons and charged particles at energies below 250 MeV, together with the continuously increasing power of nowadays computers, makes systematic use of simulations with realistic geometries possible, yielding equipment and site specific evaluation of the source terms, shielding requirements and all quantities relevant to radiation protection. In this work, the well-known Monte Carlo code FLUKA was used to simulate two representative models of cyclotron for PET radionuclides production, including their targetry; and one type of proton therapy cyclotron including the energy selection system. Simulations yield estimates of various quantities of radiological interest, including the effective dose distribution around the equipment, the effective number of neutron produced per incident proton and the activation of target materials, the structure of the cyclotron, the energy degrader, the vault walls and the soil. The model was validated against experimental measurements and comparison with well-established reference data. Neutron ambient dose equivalent H*(10) was measured around a GE PETtrace cyclotron: an average ratio between experimental measurement and simulations of 0.99±0.07 was found. Saturation yield of 18F, produced by the well-known 18O(p,n)18F reaction, was calculated and compared with the IAEA recommended

Development of HM12 cyclotron for PET

International Nuclear Information System (INIS)

Morita, Takuzo; Kawama, Tetsuo; Fujii, Kazuo

2000-01-01

In Japan, there are at present more than 30 PET (Positron Emission Tomography) facilities. The movements of medical insurance application to the PET diagnosis using [ 18 F] FDG (2-[ 18 F]-fluoro-2-deoxy-glucose) by the Ministry of Health and Welfare are being enhanced by PET related people. Therefore, more clinical centers using PET system are expected to be built in the near future. HM12 cyclotron was developed to meet such market demands for PET, and the prototype machine has been rent to Cyclotron Radio Isotope Center (CYRIC) of Tohoku University since Oct. 1998 for their use of clinical research with positron emitters like 11 C, 13 N, 15 O and 18 F. We got many technical data of HM12 Cyclotron on the clinical base. The data was enough to establish the reliability of HM12 system operation under the clinical condition. The first commercial product of HM12 Cyclotron was delivered to National Cancer Center in March 2000. The final performance test will be finished by the end of June 2000. (author)

Effect of materials and manufacturing on the bending stiffness of vaulting poles

Science.gov (United States)

Davis, C. L.; Kukureka, S. N.

2012-09-01

The increase in the world record height achieved in pole vaulting can be related to the improved ability of the athletes, in terms of their fitness and technique, and to the change in materials used to construct the pole. For example in 1960 there was a change in vaulting pole construction from bamboo to glass fibre reinforced polymer (GFRP) composites. The lighter GFRP pole enabled the athletes to have a faster run-up, resulting in a greater take-off speed, giving them more kinetic energy to convert into potential energy and hence height. GFRP poles also have a much higher failure stress than bamboo, so the poles were engineered to bend under the load of the athlete, thereby storing elastic strain energy that can be released as the pole straightens, resulting in greater energy efficiency. The bending also allowed athletes to change their vaulting technique from a style that involved the body remaining almost upright during the vault to one where the athlete goes over the bar with their feet upwards. Modern vaulting poles can be made from GFRP and/or carbon fibre reinforced polymer (CFRP) composites. The addition of carbon fibres maintains the mechanical properties of the pole, but allows a reduction in the weight. The number and arrangement of the fibres determines the mechanical properties, in particular the bending stiffness. Vaulting poles are also designed for an individual athlete to take into account each athlete’s ability and physical characteristics. The poles are rated by ‘weight’ to allow athletes to select an appropriate pole for their ability. This paper will review the development of vaulting poles and the requirements to maximize performance. The properties (bending stiffness and pre-bend) and microstructure (fibre volume fraction and lay-up) of typical vaulting poles will be discussed. Originally published as Davis C L and Kukureka S N (2004) Effect of materials and manufacturing on the bending stiffness of vaulting poles The Engineering of

Radiation protection studies for medical particle accelerators using FLUKA Monte Carlo code

International Nuclear Information System (INIS)

Infantino, Angelo; Mostacci, Domiziano; Cicoria, Gianfranco; Lucconi, Giulia; Pancaldi, Davide; Vichi, Sara; Zagni, Federico; Marengo, Mario

2017-01-01

Radiation protection (RP) in the use of medical cyclotrons involves many aspects both in the routine use and for the decommissioning of a site. Guidelines for site planning and installation, as well as for RP assessment, are given in international documents; however, the latter typically offer analytic methods of calculation of shielding and materials activation, in approximate or idealised geometry set-ups. The availability of Monte Carlo (MC) codes with accurate up-to-date libraries for transport and interaction of neutrons and charged particles at energies below 250 MeV, together with the continuously increasing power of modern computers, makes the systematic use of simulations with realistic geometries possible, yielding equipment and site-specific evaluation of the source terms, shielding requirements and all quantities relevant to RP at the same time. In this work, the well-known FLUKA MC code was used to simulate different aspects of RP in the use of biomedical accelerators, particularly for the production of medical radioisotopes. In the context of the Young Professionals Award, held at the IRPA 14 conference, only a part of the complete work is presented. In particular, the simulation of the GE PETtrace cyclotron (16.5 MeV) installed at S. Orsola-Malpighi University Hospital evaluated the effective dose distribution around the equipment; the effective number of neutrons produced per incident proton and their spectral distribution; the activation of the structure of the cyclotron and the vault walls; the activation of the ambient air, in particular the production of "4"1Ar. The simulations were validated, in terms of physical and transport parameters to be used at the energy range of interest, through an extensive measurement campaign of the neutron environmental dose equivalent using a rem-counter and TLD dosemeters. The validated model was then used in the design and the licensing request of a new Positron Emission Tomography facility. (authors)

Superconducting cyclotrons

International Nuclear Information System (INIS)

Blosser, H.G.; Johnson, D.A.; Burleigh, R.J.

1976-01-01

Superconducting cyclotrons are particularly appropriate for acceleration of heavy ions. A review is given of design features of a superconducting cyclotron with energy 440 (Q 2 /A) MeV. A strong magnetic field (4.6 tesla average) leads to small physical size (extraction radius 65 cm) and low construction costs. Operating costs are also low. The design is based on established technology (from present cyclotrons and from large bubble chambers). Two laboratories (in Chalk River, Canada and in East Lansing, Michigan) are proceeding with construction of full-scale prototype components for such cyclotrons

The Acoustics of the Double Elliptical Vault of the Royal Palace of Caserta (Italy

Directory of Open Access Journals (Sweden)

Umberto Berardi

2017-03-01

Full Text Available This work investigates the acoustic characteristics of the double elliptical vault, which overlooks the Grand Staircase of the Royal Palace of Caserta (Italy. The Royal Palace was built by the architect Luigi Vanvitelli in the Seventeenth Century and it is the largest royal building in Italy. The double elliptical vault presents a great scenography effect. Inside the vault, on the planking level, musicians used to play for the king and his guests when the royal procession, going up the grand staircase, entered the royal apartments, creating astonishment among the guests who heard the music without understanding from where it was coming. Since the musicians were inside the vault, the long reverberation made the listeners perceive the vault to be enveloped by the music. To investigate this effect, the acoustic characteristics of the double vault were measured, putting the sound source on the planking level of the vault, while the microphones were put along the staircase and in the vestibule towards the royal apartments. Finally, the spatial distribution of several acoustic parameters is evaluated also using architectural acoustic simulations.

Decommissioning analyzis of a university cyclotron

International Nuclear Information System (INIS)

Eggermont, G.X.; Buls, N.; Hermanne, A.

1996-01-01

In the widespread use of some medical nuclear facilities, such as cyclotrons for isotope production, Life cycle analyzis, including decommissioning, was not taken into account. The structural materials of an accelerator and the concrete shielding of the bunker are activated by neutrons. This could yield a considerable volume of nuclear waste and needs radiation protection concern for occupational workers and the environment during some decennia. At the university of Brussels (WB) a prospective radiation protection and waste analyzis is being made for the later decommissioning of their cyclotron. Only few similar studies have been published. In Belgium future nuclear dismantling operations will be submitted to a radiation protection authorization procedure. Meanwhile the nuclear waste authorities insist on dismantling planning, including financial provisioning. An optimization exercise was made at the VUB-cyclotron, taking into account international trends to clearance levels for low level nuclear waste. Conceptual prevention opportunities e.g. selective material choice could be identified for future accelerator constructions. (author)

Design features and operating characteristics of the MC-50 cyclotron

International Nuclear Information System (INIS)

Bak, Hae Ill; Bak, Joo Shik

1989-01-01

The MC-50 cyclotron at Korean Cancer Center Hospital is now operational for neutron therapy and medical radioisotope production. Design features, mechanical structures and operating characteristics of the MC-50 are described in this paper. Optimum operating condition for this cyclotron has been determined by the repetitive running, and the performances of the internal beam have been investigated through the measurements of intensity and spatial distribution of the internal beam as a function of the radius of the cyclotron. Routinely, the 40 μA of 50 MeV protons have been obtained at first Faraday cup with a extraction efficiency of 61%. (Author)

Cryoelectron microscopy imaging of recombinant and tissue derived vaults: localization of the MVP N termini and VPARP.

Science.gov (United States)

Mikyas, Yeshi; Makabi, Miriam; Raval-Fernandes, Sujna; Harrington, Lea; Kickhoefer, Valerie A; Rome, Leonard H; Stewart, Phoebe L

2004-11-12

The vault is a highly conserved ribonucleoprotein particle found in all higher eukaryotes. It has a barrel-shaped structure and is composed of the major vault protein (MVP); vault poly(ADP-ribose) polymerase (VPARP); telomerase-associated protein 1 (TEP1); and small untranslated RNA (vRNA). Although its strong conservation and high abundance indicate an important cellular role, the function of the vault is unknown. In humans, vaults have been implicated in multidrug resistance during chemotherapy. Recently, assembly of recombinant vaults has been established in insect cells expressing only MVP. Here, we demonstrate that co-expression of MVP with one or both of the other two vault proteins results in their co-assembly into regularly shaped vaults. Particles assembled from MVP with N-terminal peptide tags of various length are compared. Cryoelectron microscopy (cryoEM) and single-particle image reconstruction methods were used to determine the structure of nine recombinant vaults of various composition, as well as wild-type and TEP1-deficient mouse vaults. Recombinant vaults with MVP N-terminal peptide tags showed internal density that varied in size with the length of the tag. Reconstruction of a recombinant vault with a cysteine-rich tag revealed 48-fold rotational symmetry for the vault. A model is proposed for the organization of MVP within the vault with all of the MVP N termini interacting non-covalently at the vault midsection and 48 copies of MVP forming each half vault. CryoEM difference mapping localized VPARP to three density bands lining the inner surface of the vault. Difference maps designed to localize TEP1 showed only weak density inside of the caps, suggesting that TEP1 may interact with MVP via a small interaction region. In the absence of atomic-resolution structures for either VPARP or TEP1, fold recognition methods were applied. A total of 21 repeats were predicted for the TEP1 WD-repeat domain, suggesting an unusually large beta-propeller fold.

HYDRAULIC AND PHYSICAL PROPERTIES OF SALTSTONE GROUTS AND VAULT CONCRETES

International Nuclear Information System (INIS)

Dixon, K.; Harbour, J.; Phifer, M.

2008-01-01

The Saltstone Disposal Facility (SDF), located in the Z-Area of the Savannah River Site (SRS), is used for the disposal of low-level radioactive salt solution. The SDF currently contains two vaults: Vault 1 (6 cells) and Vault 4 (12 cells). Additional disposal cells are currently in the design phase. The individual cells of the saltstone facility are filled with saltstone. Saltstone is produced by mixing the low-level radioactive salt solution, with blast furnace slag, fly ash, and cement (dry premix) to form a dense, micro-porous, monolithic, low-level radioactive waste form. The saltstone is pumped into the disposal cells where it subsequently solidifies. Significant effort has been undertaken to accurately model the movement of water and contaminants through the facility. Key to this effort is an accurate understanding of the hydraulic and physical properties of the solidified saltstone. To date, limited testing has been conducted to characterize the saltstone. The primary focus of this task was to estimate the hydraulic and physical properties of three types of saltstone and two vault concretes. The saltstone formulations included saltstone premix batched with (1) Deliquification, Dissolution, and Adjustment (DDA) salt simulant (w/pm 0.60), (2) Actinide Removal Process (ARP)/Modular Caustic Side Solvent Extraction Unit (MCU) salt simulant (w/pm 0.60), and (3) Salt Waste Processing Facility (SWPF) salt simulant (w/pm 0.60). The vault concrete formulations tested included the Vault 1/4 concrete and two variations of the Vault 2 concrete (Mix 1 and Mix 2). Wet properties measured for the saltstone formulations included yield stress, plastic viscosity, wet unit weight, bleed water volume, gel time, set time, and heat of hydration. Hydraulic and physical properties measured on the cured saltstone and concrete samples included saturated hydraulic conductivity, moisture retention, compressive strength, porosity, particle density, and dry bulk density. These properties

Fusée ceramic vaults and domes in the Netherlands

NARCIS (Netherlands)

Kamerling, M.W.

2011-01-01

This paper gives an overview of the fusée Ceramique vaults and domes constructed in The Netherlands just after World War II and describes the technique of construction as well as the advantages and disadvantages. Using only a minimum of concrete and steel, the environmental load of the vaults is

Radiation protection problems by the operation of the cyclotron facility

International Nuclear Information System (INIS)

Durcik, M.; Nikodemova, D.

1998-01-01

The Cyclotron Center in Bratislava will consist of two cyclotrons. First - cyclotron DC-72 with maximal energy of 72 MV for protons for making experiments, for teaching process, for radioisotope production as 123 I and for neutron and proton therapy. Second - compact cyclotron with maximal proton energy of 18 MeV will be used for radioisotopes production for medical diagnosis as 1 *F (fluorodeoxyglucose), 81 Rb/ 81 Kr generator. This paper deals with the radiation protection problems by the operation of tis cyclotron facility as radiation protection of workers, monitoring plan, ventilation, safety lock and limitation and radiation monitoring. For proposed and continuing practices at the accelerator facility, the following general principles have to be fulfilled: (1) practices should produce sufficient benefit to offset the radiation detriment they case (justification); (2) the magnitude of the individual doses should be kept as low as achievable (optimization of protection); (3) individual exposures are subject to dose limits and some control of risk from potential exposures (dose and risk limits)

Engineering and safety features of modular vault dry storage

International Nuclear Information System (INIS)

Deacon, D.; Wheeler, D.J.

1984-01-01

This paper discusses the need for interim dry storage and reviews detailed features of the Modular Vault Dry storage concept. The concept meets three basic utility requirements. Firstly, the technology and safety features have been demonstrated on existing plant; secondly, it can be built and licensed in an acceptably short timescale; and thirdly, economic analysis shows that a modular vault dry store is often the cheapest option for interim storage

The performance assessment and the design of an intermediate level tritium disposal vault

International Nuclear Information System (INIS)

Yu, A.D.

1991-01-01

The topic of this report is the assessment of the performance and design of the tritium disposal vault for the Westinghouse River Company at the Savannah River Laboratory. This paper describes how the groundwater modeling has affected the design of a tritium disposal vault at the Savannah River Site and this new vault will meet the regulatory performance requirements. (MB)

Vancouver Cyclotron Conference

International Nuclear Information System (INIS)

Clark, David J.

1993-01-01

Although no longer on the high energy frontier, the cyclotron field is still a major scientific growth area. Its progress is highlighted at the international conference on cyclotron design, development and utilization held at intervals of about three years, under the auspices of the International Union of Pure and Applied Physics (IUPAP). Vancouver, surrounded by mountains, water and some cyclotrons, provided a pleasant setting for the 13th Conference, held last summer. With over 200 cyclotrons in operation around the world, the attendance, 241 delegates and 26 industrial exhibitors, was a near record, reflecting the flourishing state of the field. The early sessions covered the initial operation of new or upgraded cyclotron facilities. Major facilities completed since the previous Conference in Berlin in May 1989 included the 400 MeV ring cyclotron at Osaka, the U400M cyclotron at Dubna which will be coupled to the U400 to give 20 MeV nucléon uranium beams, the 130 MeV cyclotron at Jyvaskyla (in Finland, the furthest north!), the 110 MeV JAERI machine in Japan, and the 65 MeV proton therapy cyclotron in Nice. Among the facility upgrades were the KFA cyclotron at Julich which will inject the 2.5 GeV storage ring COSY, and the addition of an FM mode to the K=200 CW mode at Uppsala to give protons up to 180 MeV. The impressive current of 1.5 mA at 72 MeV obtained from the PSI Injector II will soon be injected into the 590 MeV ring

Desalination of painted brick vaults

DEFF Research Database (Denmark)

Larsen, Poul Klenz

The subject of the thesis is salt and moisture movement that causes damage to wall paintings on church vaults. The deterioration was studied in the churches of Fanefjord, Kirkerup and Brarup. A desalination method was tested om location. The salt and moisture transfer was examined in detail...

Is Postoperative Intensive Care Unit Care Necessary following Cranial Vault Remodeling for Sagittal Synostosis?

Science.gov (United States)

Wolfswinkel, Erik M; Howell, Lori K; Fahradyan, Artur; Azadgoli, Beina; McComb, J Gordon; Urata, Mark M

2017-12-01

Of U.S. craniofacial and neurosurgeons, 94 percent routinely admit patients to the intensive care unit following cranial vault remodeling for correction of sagittal synostosis. This study aims to examine the outcomes and cost of direct ward admission following primary cranial vault remodeling for sagittal synostosis. An institutional review board-approved retrospective review was undertaken of the records of all patients who underwent primary cranial vault remodeling for isolated sagittal craniosynostosis from 2009 to 2015 at a single pediatric hospital. Patient demographics, perioperative course, and outcomes were recorded. One hundred ten patients met inclusion criteria with absence of other major medical problems. Average age at operation was 6.7 months, with a mean follow-up of 19.8 months. Ninety-eight patients (89 percent) were admitted to a general ward for postoperative care, whereas the remaining 12 (11 percent) were admitted to the intensive care unit for preoperative or perioperative concerns. Among ward-admitted patients, there were four (3.6 percent) minor complications; however, there were no major adverse events, with none necessitating intensive care unit transfers from the ward and no mortalities. Average hospital stay was 3.7 days. The institution's financial difference in cost of intensive care unit stay versus ward bed was $5520 on average per bed per day. Omitting just one intensive care unit postoperative day stay for this patient cohort would reduce projected health care costs by a total of $540,960 for the study period. Despite the common practice of postoperative admission to the intensive care unit following cranial vault remodeling for sagittal craniosynostosis, the authors suggest that postoperative care be considered on an individual basis, with only a small percentage requiring a higher level of care. Therapeutic, III.

Solid targets for production of radioisotopes with cyclotron

International Nuclear Information System (INIS)

Paredes G, L.; Balcazar G, M.

1999-01-01

The design of targets for production of radioisotopes and radiopharmaceuticals of cyclotron to medical applications requires a detailed analysis of several variables such as: cyclotron operation conditions, choice of used materials as target and their physicochemical characteristics, activity calculation, the yielding of each radioisotope by irradiation, the competition of nuclear reactions in function of the projectiles energy and the collision processes amongst others. The objective of this work is to determine the equations for the calculation for yielding of solid targets at the end of the proton irradiation. (Author)

Analysis of Hydrogen Generation and Accumulation in U-233 Tube Vaults

International Nuclear Information System (INIS)

Ally, M.R.; Willis, K.J.

1999-01-01

The purpose of the 233 U Safe Storage Program is to enhance the safe storage of 233 U-bearing materials. This report describes the work done at the Oak Ridge National Laboratory's Radiochemical Development Facility (RDF) to address questions related to possible hydrogen generation and accumulation in 233 U tube vaults. The objective of this effort was to verify assumptions in the mathematical model used to estimate the hydrogen content of the gaseous atmosphere that possibly could occur inside the tube vaults in Building 3019 and to evaluate proposed measures for mitigating any hydrogen concerns. A mathematical model was developed using conservative assumptions to evaluate possible hydrogen generation and accumulation in the tube vaults. The model concluded that an equilibrium concentration would be established below the lower flammability limit (LFL) of 4.1% hydrogen. The major assumptions used in the model that were validated are as follows: (1) The shield plug does not form a seal with the tube vault wall, thus allowing the hydrogen gas to diffuse past the shield plug to the upper section of the tube vault. (2) The tube vault end-cap leaks sufficiently to allow air to be drawn into the tube vault by the off-gas system, thereby purging hydrogen from the upper section of the tube vault. (3) Any hydrogen gas generated completely mixes with the other gases present in the lower section of the tube vault and does not stratify beneath the shield plug. (4) The diffusion coefficient determined from the literature for constant diffusion of hydrogen in air is valid. The coefficient is corrected for temperatures from 0 to 25 C. Another assumption used in the model, that hydrogen generated by radiolytic decomposition of hydrogen-bearing materials (e.g., moisture and plastic) leaks from the cans under steady-state condition, as opposed to a sudden release resulting from rupture of the can(s), was beyond the scope of this investigation. Several parameters from the original

Regulatory Compliance to Assure the Safety of the Operation of a Medical Cyclotron

International Nuclear Information System (INIS)

Dela Cruz, Joselito

2015-01-01

Khealth Corporation, in Partnership with the National Kidney and Transplant Institute, has established a medical cyclotron facility to accommodate the up-and-coming needs of tracers for PET/CT in different centers and hospitals all over the country. This facility houses a 16.5 MeV GE PET trace 880 particle accelerator that can produce 14 Ci (518 GBq) of Fluorine-18. Its structure has adopted global standard designs in meeting the safety during its use, radiopharmaceutical production and distribution. Compliances were remarkably fulfilled from the building construction, machine acquisition, commissioning, operations up to the quality control and assurance. Furthermore, various regulatory challenges during the current standardization of radiopharmaceutical utilization were encountered however time dedication and efforts were wielded until all have been successfully justified and acquired. (author)

A prediction model for the radiation safety management behavior of medical cyclotrons

International Nuclear Information System (INIS)

Jung, Ji Hye; Han, Eun Ok; Kim, Ssang Tae

2008-01-01

This study attempted to provide reference materials for improving the behavior level in radiation safety managements by drawing a prediction model that affects the radiation safety management behavior because the radiation safety management of medical Cyclotrons, which can be used to produce radioisotopes, is an important factor that protects radiation caused diseases not only for radiological operators but average users. In addition, this study obtained follows results through the investigation applied from January 2 to January 30, 2008 for the radiation safety managers employed in 24 authorized organizations, which have already installed Cyclotrons, through applying a specific form of questionnaire in which the validity was guaranteed by reference study, site investigation, and focus discussion by related experts. The radiation safety management were configured as seven steps: step 1 is a production preparation step, step 2 is an RI production step, step 3 is a synthesis step, step 4 is a distribution step, step 5 is a quality control step, step 6 is a carriage container packing step, and step 7 is a transportation step. It was recognized that the distribution step was the most exposed as 15 subjects (62.5%), the items of 'the sanction and permission related works' and 'the guarantee of installation facilities and production equipment' were the most difficult as 9 subjects (37.5%), and in the trouble steps in such exposure, the item of 'the synthesis and distribution' steps were 4 times, respectively (30.8%). In the score of the behavior level in radiation safety managements, the minimum and maximum scores were 2.42 and 4.00, respectively, and the average score was 3.46 ± 0.47 out of 4. Prosperity and well-being programs in the behavior and job in radiation safety managements (r=0.529) represented a significant correlation statistically. In the drawing of a prediction model based on the factors that affected the behavior in radiation safety managements, general

Seismic Behaviour of Masonry Vault-Slab Structures

International Nuclear Information System (INIS)

Chesi, Claudio; Butti, Ferdinando; Ferrari, Marco

2008-01-01

Spandrel walls typically play a structural role in masonry buildings, transferring load from a slab to the supporting vault. Some indications are given in the literature on the behaviour of spandrels under the effect of vertical loads, but little attention is given to the effect coming from lateral forces acting on the building. An opportunity to investigate this problem has come from the need of analyzing a monumental building which was damaged by the Nov. 24, 2004 Val Sabbia earthquake in the north of Italy. The finite element model set up for the analysis of the vault-spandrel-slab system is presented and the structural role resulting for the spandrels is discussed

Experiments for post accident hydrogen dispersion in F.M. vault using helium

International Nuclear Information System (INIS)

Bajaj, S.S.; Bhattacharyya, D.; Mishra, S.

1994-01-01

Under certain postulated accident scenarios involving a Loss of Coolant Accident (LOCA) simultaneous with impairment of Emergency Core Cooling (ECC), generation of hydrogen due to reaction between the zirconium clad and coolant is predicted in the coolant channel. The hydrogen generated in the coolant channels would eventually get released either in Fuelling Machine (FM) vault or in the pump room atmosphere depending on the location of the break. Analytical studies carried out so far to estimate the time dependent hydrogen concentration in the accident FM Vault consider the entire vault as a single volume. Tests were, therefore, planned to assess the mixing within the FM vault atmosphere with and without the availability of cooling fan units by releasing a known quantity of helium (instead of hydrogen) at selected locations and monitoring the relative concentration of helium in air at various locations. Test was conducted by releasing about 360 1 helium over a period of to 4 minutes at preselected locations and by measuring the relative concentration (leak rates indicated by helium leak detectors) at various locations in the FM vault. The results of cases with fans operating indicate repeatable and consistent trends of good mixing in the vault. For other cases (non turbulent, still condition) the results are sensitive to various factors including orientation of release. The former set of cases (turbulent. fans operating) are more relevant for postulated accident conditions. (author). 1 tab., 18 figs

Health physics challenges involved with opening a "seventeen-inch" concrete waste vault.

Science.gov (United States)

Sullivan, Patrick T; Pizzulli, Michelle

2005-05-01

This paper describes the various activities involved with opening a sealed legacy "Seventeen-inch" concrete vault and the health physics challenges and solutions employed. As part of a legacy waste stream that was removed from the former Hazardous Waste Management Facility at Brookhaven National Laboratory, the "Seventeen-inch" concrete vault labeled 1-95 was moved to the new Waste Management Facility for ultimate disposal. Because the vault contained 239Pu foils with a total activity in excess of the transuranic waste limits, the foils needed to be removed and repackaged for disposal. Conventional diamond wire saws could not be used because of facility constraints, so this project relied mainly on manual techniques. The planning and engineering controls put in place enabled personnel to open the vault and remove the waste while keeping dose as low as reasonably achievable.

Neutron radiography by using JSW baby cyclotron

International Nuclear Information System (INIS)

Toda, Yojiro

1995-01-01

At present, JSW baby cyclotrons are mostly used for the production of the radioisotopes for medical use. The attempt to use this baby cyclotron for neutron radiography began already in 1981. The feasibility of the neutron radiography for the explosives in metallic cases which are used for H1 rockets was investigated. In 1983, it was shown that the neutron radiography by using the baby cyclotron in Muroran Works, Japan Steel Works, Ltd. was able to be carried out as a routine work. Since then, the nondestructive inspection by neutron radiography has been performed for rocket pyrotechnic articles, and contributed to heighten their reliability. Further, the radiography by using fast neutrons was developed and put to practical use for recent large H2 rockets. The JSW baby cyclotron BC 168 which has been used for neutron radiography can accelerate 16 MeV protons or 8 MeV deuterons up to 50 μA. The principle of thermal neutron radiography is the generation of fast neutrons by irradiating a Be target with the proton beam accelerated by a baby cyclotron, the moderation of the fast neutrons, the formation of the thermal neutron flux of uniform distribution with a collimator, the thermal neutron flux hitting the Gd plate in a film cassette through an object, and the exposure of an X-ray film to electrons from the Gd plate. Fast neutron radiography apparatus, and commercial neutron radiography are described. (K.I.)

Special Analysis: Revision of Saltstone Vault 4 Disposal Limits (U)

Energy Technology Data Exchange (ETDEWEB)

Cook, J

2005-05-26

New disposal limits have been computed for Vault 4 of the Saltstone Disposal Facility based on several revisions to the models in the existing Performance Assessment and the Special Analysis issued in 2002. The most important changes are the use of a more rigorous groundwater flow and transport model, and consideration of radon emanation. Other revisions include refinement of the aquifer mesh to more accurately model the footprint of the vault, a new plutonium chemistry model accounting for the different transport properties of oxidation states III/IV and V/VI, use of variable infiltration rates to simulate degradation of the closure system, explicit calculation of gaseous releases and consideration of the effects of settlement and seismic activity on the vault structure. The disposal limits have been compared with the projected total inventory expected to be disposed in Vault 4. The resulting sum-of-fractions of the 1000-year disposal limits is 0.2, which indicates that the performance objectives and requirements of DOE 435.1 will not be exceeded. This SA has not altered the conceptual model (i.e., migration of radionuclides from the Saltstone waste form and Vault 4 to the environment via the processes of diffusion and advection) of the Saltstone PA (MMES 1992) nor has it altered the conclusions of the PA (i.e., disposal of the proposed waste in the SDF will meet DOE performance measures). Thus a PA revision is not required and this SA serves to update the disposal limits for Vault 4. In addition, projected doses have been calculated for comparison with the performance objectives laid out in 10 CFR 61. These doses are 0.05 mrem/year to a member of the public and 21.5 mrem/year to an inadvertent intruder in the resident scenario over a 10,000-year time-frame, which demonstrates that the 10 CFR 61 performance objectives will not be exceeded. This SA supplements the Saltstone PA and supersedes the two previous SAs (Cook et al. 2002; Cook and Kaplan 2003).

MICHIGAN: Cyclotron conference

Energy Technology Data Exchange (ETDEWEB)

Anon.

1984-10-15

A sense of excitement was in the air as cyclotron physicists and engineers from 17 countries convened on 30 April for the opening of the Tenth International Conference on Cyclotrons and Their Applications. Some 50 years after its invention, the redoubtable cyclotron remains a topic of compelling current interest. Cyclotron experts gathered at Michigan State University's Kellogg Center to hear of latest developments, of progress and successes on new machines which had come into operation, of new projects which were underway, and of dreams which lay ahead.

Risk Management in the Original Extreme Sporting Event: The Pole Vault

Science.gov (United States)

Bemiller, Jim; Hardin, Robin

2010-01-01

The pole vault was considered the ultimate test of physical ability and daring before the advent of modern extreme sports such as skateboarding, snowboarding, and mountain biking. The inherent risks of the pole vault have been well documented. The National Center for Catastrophic Sport Injury Research reported in 2007 that the catastrophic injury…

Electromagnetic cyclotron harmonic waves

International Nuclear Information System (INIS)

Ohnuma, T.; Watanabe, T.; Hamamatsu, K.

1981-09-01

Electromagnetic electron cyclotron harmonic waves just below the electron cyclotron harmonics are investigated numerically and experimentally. Backward waves which are observed to propagate nearly perpendicular to the magnetic field just below the electron cyclotron frequency in a high density magnetoplasma are confirmed to be in accord with the theoretical electromagnetic cyclotron waves. (author)

MICHIGAN: Cyclotron conference

International Nuclear Information System (INIS)

Anon.

1984-01-01

A sense of excitement was in the air as cyclotron physicists and engineers from 17 countries convened on 30 April for the opening of the Tenth International Conference on Cyclotrons and Their Applications. Some 50 years after its invention, the redoubtable cyclotron remains a topic of compelling current interest. Cyclotron experts gathered at Michigan State University's Kellogg Center to hear of latest developments, of progress and successes on new machines which had come into operation, of new projects which were underway, and of dreams which lay ahead

3D SURVEYING AND GEOMETRIC ASSESSMENT OF A GOTHIC NAVE VAULTING FROM POINT CLOUDS

Directory of Open Access Journals (Sweden)

A. Costa-Jover

2017-02-01

Full Text Available The development of massive data captures techniques (MDC in recent years, such as the Terrestrial laser Scanner (TLS, raises the possibility of developing new assessment procedures for architectural heritage. The 3D models that it is able to obtain is a great potential tool, both for conservation purposes and for historical and architectural studies. The paper proposes a simple, non-invasive methodology for the assessment of masonry vaults from point clouds which makes it possible to obtain relevant data about the formal anomalies. The methodology is tested in Tortosa’s Gothic Cathedral’s vaults, where the geometrical differences between vaults, a priori equal, are identified and related with the partially known construction phases. The procedure can be easily used on any other vaulted construction of any kind, but is especially useful to deal with the complex geometry of Gothic masonry vaults.

Automated cyclotron tuning using beam phase measurements

International Nuclear Information System (INIS)

Timmer, J.H.; Roecken, H.; Stephani, T.; Baumgarten, C.; Geisler, A.

2006-01-01

The ACCEL K250 superconducting cyclotron is specifically designed for the use in proton therapy systems. The compact medical 250 MeV proton accelerator fulfils all present and future beam requirements for fast scanning treatment systems and is delivered as a turn key system; no operator is routinely required. During operation of the cyclotron heat dissipation of the RF system induces a small drift in iron temperature. This temperature drift slightly detunes the magnetic field and small corrections must be made. A non-destructive beam phase detector has been developed to measure and quantify the effect of a magnetic field drift. Signal calculations were made and the design of the capacitive pickup probe was optimised to cover the desired beam current range. Measurements showed a very good agreement with the calculated signals and beam phase can be measured with currents down to 3 nA. The measured phase values are used as input for a feedback loop controlling the current in the superconducting coil. The magnetic field of the cyclotron is tuned automatically and online to maintain a fixed beam phase. Extraction efficiency is thereby optimised continuously and activation of the cyclotron is minimised. The energy and position stability of the extracted beam are well within specification

Nitrate Diffusional Releases from the Saltstone Facility, Vault 2, with Respect to Different Concrete Wall Thicknesses

International Nuclear Information System (INIS)

ROBERT, HIERGESELL

2005-01-01

To assist the Saltstone Vault 2 Design Team, an investigation was conducted to evaluate the effectiveness of alternative concrete wall thicknesses in limiting nitrate diffusion away from the planned facility. While the current design calls for 18-inch concrete walls, alternative thicknesses of 12-in, 8-in, and 6-in were evaluated using a simplified 1-D numerical model. To serve as a guide for Saltstone Vault 2 conceptual design, the results of this investigation were applied to Saltstone Vault 4 to determine what the hypothetical limits would be for concrete wall thicknesses thinner than the planned 18-inches. This was accomplished by adjusting the Vault 4 Limits, based on the increased nitrate diffusion rates through the thinner concrete walls, such that the 100-m well limit of 44 mg/L of nitrate as nitrate was not exceeded. The implication of these preliminary results is that as thinner vault walls are implemented there is a larger release of nitrate, thus necessitating optimal vault placement to minimize the number of vaults placed along a single groundwater flow path leading to the discharge zone

A preliminary assessment of temperature distributions associated with a radioactive waste vault

International Nuclear Information System (INIS)

Tammemagi, H.Y.

1978-09-01

The temperature distributions of models which simulated radioactive waste vaults were determined, using a finite difference computer code to solve the transient heat conduction equation. Input parameters to the code included thermal properties for granitic rock and heat generation decay data for wastes that would be separated from CANDU fuel if it were recycled. Due to the preliminary nature of the study, only simple models were analysed. A disc source was utilized to approximate a one-level repository. Various parameters were investigated such as depth of disc, thermal properties of rock, and long-term effects. It was shown that, for a vault at 500 m depth with an initial areal heat flux of 31 W/m 2 , a maximum temperature increase of about 80 deg C occurs at the vault level about 30 years after waste emplacement; maximum increases near the earth's surface occur after about 1000 years and are less than 1 deg C. Modelling the vault by a number of vertical waste boreholes on one horizontal level, instead of by a disc, with the gross areal heat flux again 31 W/m 2 , did not cause serious local temperature increases as long as the initial heat generation rate of each container was less than about 750 W. It was also shown that, by using the vertical dimension available in granitic plutons and constructing either multiple-level vaults or very deep boreholes, initial areal heat fluxes greater than 31 W/m 2 can be utilized without exceeding the 80 deg C maximum temperature increase anywhere in the vault. (author)

Electrochemical desalination of the ionic mixture measured in the vault of Rørby Church - Laboratory scale

DEFF Research Database (Denmark)

Rörig-Dalgaard, Inge; Bøllingtoft, P.

2011-01-01

Salt induced deterioration of the vault in Rørby Church has resulted in extensive deterioration of the vault itself and of the murals on the lower surface of the vault. The upper surface of the vault has previously been covered with cement mortar. After removing this cement mortar some...... of the bricks erode and form brick powder. The brick powder was collected in 2002, 2005 and 2011 and measured for the most common salts in Danish vault structures. On the basis of the actual measured ions two different salt mixtures were made and used for contamination of brick specimens. By use of an applied...

Preoperative Biometric Parameters Predict the Vault after ICL Implantation: A Retrospective Clinical Study.

Science.gov (United States)

Zheng, Qian-Yin; Xu, Wen; Liang, Guan-Lu; Wu, Jing; Shi, Jun-Ting

2016-01-01

To investigate the correlation between the preoperative biometric parameters of the anterior segment and the vault after implantable Collamer lens (ICL) implantation via this retrospective study. Retrospective clinical study. A total of 78 eyes from 41 patients who underwent ICL implantation surgery were included in this study. Preoperative biometric parameters, including white-to-white (WTW) diameter, central corneal thickness, keratometer, pupil diameter, anterior chamber depth, sulcus-to-sulcus diameter, anterior chamber area (ACA) and central curvature radius of the anterior surface of the lens (Lenscur), were measured. Lenscur and ACA were measured with Rhinoceros 5.0 software on the image scanned with ultrasound biomicroscopy (UBM). The vault was assessed by UBM 3 months after surgery. Multiple stepwise regression analysis was employed to identify the variables that were correlated with the vault. The results showed that the vault was correlated with 3 variables: ACA (22.4 ± 4.25 mm2), WTW (11.36 ± 0.29 mm) and Lenscur (9.15 ± 1.21 mm). The regressive equation was: vault (mm) = 1.785 + 0.017 × ACA + 0.051 × Lenscur - 0.203 × WTW. Biometric parameters of the anterior segment (ACA, WTW and Lenscur) can predict the vault after ICL implantation using a new regression equation. © 2016 The Author(s) Published by S. Karger AG, Basel.

Risk assessment of 30 MeV cyclotron facilities

Energy Technology Data Exchange (ETDEWEB)

Jeong, Gyo Seong; Lee, Jin Woo [Advanced Radiation Technology Institute, Korea Atomic Energy Research Institute, Jeongeup (Korea, Republic of); Kim, Chong Yeal [Dept. of Radiation Science and Technology, Chonbuk National University, Jeonju (Korea, Republic of)

2017-03-15

A cyclotron is a kind of particle accelerator that produces a beam of charged particles for the production of medical, industrial, and research radioisotopes. More than 30 cyclotrons are operated in Korea to produce 18F, an FDG synthesis at hospitals. A 30-MeV cyclotron was installed at ARTI (Advanced Radiation Technology Institute, KAERI) mainly for research regarding isotope production. In this study, we analyze and estimate the items of risk such as the problems in the main components of the cyclotron, the loss of radioactive materials, the leakage of coolant, and the malfunction of utilities, fres and earthquakes. To estimate the occurrence frequency in an accident risk assessment, five levels, i.e., Almost certain, Likely, Possible, Unlikely, and Rare, are applied. The accident consequence level is classified under four grades based on the annual permissible dose for radiation workers and the public in the nuclear safety law. The analysis of the accident effect is focused on the radioactive contamination caused by radioisotope leakage and radioactive material leakage of a ventilation filter due to a free. To analyze the risks, Occupation Safety and Health Acts is applied. In addition, action plans against an accident were prepared after a deep discussion among relevant researchers. In this acts, we will search for hazard and introduce the risk assessment for the research 30-MeV cyclotron facilities of ARTI.

Risk assessment of 30 MeV cyclotron facilities

International Nuclear Information System (INIS)

Jeong, Gyo Seong; Lee, Jin Woo; Kim, Chong Yeal

2017-01-01

A cyclotron is a kind of particle accelerator that produces a beam of charged particles for the production of medical, industrial, and research radioisotopes. More than 30 cyclotrons are operated in Korea to produce 18F, an FDG synthesis at hospitals. A 30-MeV cyclotron was installed at ARTI (Advanced Radiation Technology Institute, KAERI) mainly for research regarding isotope production. In this study, we analyze and estimate the items of risk such as the problems in the main components of the cyclotron, the loss of radioactive materials, the leakage of coolant, and the malfunction of utilities, fres and earthquakes. To estimate the occurrence frequency in an accident risk assessment, five levels, i.e., Almost certain, Likely, Possible, Unlikely, and Rare, are applied. The accident consequence level is classified under four grades based on the annual permissible dose for radiation workers and the public in the nuclear safety law. The analysis of the accident effect is focused on the radioactive contamination caused by radioisotope leakage and radioactive material leakage of a ventilation filter due to a free. To analyze the risks, Occupation Safety and Health Acts is applied. In addition, action plans against an accident were prepared after a deep discussion among relevant researchers. In this acts, we will search for hazard and introduce the risk assessment for the research 30-MeV cyclotron facilities of ARTI

Cyclotron waves in plasma

CERN Document Server

Lominadze, D G

2013-01-01

Cyclotron Waves in Plasma is a four-chapter text that covers the basic physical concepts of the theory of cyclotron waves and cyclotron instabilities, brought about by the existence of steady or alternating plasma currents flowing perpendicular to the magnetic field.This book considers first a wide range of questions associated with the linear theory of cyclotron oscillations in equilibrium plasmas and in electron plasmas in metals and semiconductors. The next chapter deals with the parametric excitation of electron cyclotron oscillations in plasma in an alternating electric field. A chapter f

The PET / cyclotron facility at Putrajaya Hospital - an update

International Nuclear Information System (INIS)

Siti Najila Mohd Janib; Suzilawati Muhd Sarowi; Munira Shaikh Nasir; Zulkifli Mohamed Hashim

2006-01-01

Malaysia desire to have a cyclotron for nuclear medical use came into realisation recently with the establishment of a PET/Cyclotron Facility at Putrajaya Hospital. The testing and commissioning of the cyclotron, hot cells, QC equipment and PET/CT started on March 27, culminating in the first patient to be injected on May 10 2006. Three other patients were to be followed on May 15. The patients from both the Kuala Lumpur and Putrajaya Hospital were pre-selected by physicians from these hospitals. The 18 MeV cyclotron is capable of generating 16.4 MeV protons and 8.4 MeV deuterons. The cyclotron at Putrajaya has three targets (2 liquid and 1 gas) and is capable of producing 18 F-FDG and 18 F-DOPA. To complement this, the facility has 2 modules for FDG synthesis, 1 for F-DOPA and 1 for nucleophilic synthesis. The facility will be GMP compliant. For the first production for human use, the water-18 target was irradiated for 50 minutes at 20 mA to produce 1.3 Ci of F-18. At the end of synthesis, the activity of the FDG obtained was 600 mCi. The product was then injected to a 26-year-old female, with a suspected adenocarcinoma. (Author)

Intelligent low-level RF system by non-destructive beam monitoring device for cyclotrons

Science.gov (United States)

Sharifi Asadi Malafeh, M. S.; Ghergherehchi, M.; Afarideh, H.; Chai, J. S.; Yoon, Sang Kim

2016-04-01

The project of a 10 MeV PET cyclotron accelerator for medical diagnosis and treatment was started at Amirkabir University of Technology in 2012. The low-level RF system of the cyclotron accelerator is designed to stabilize acceleration voltage and control the resonance frequency of the cavity. In this work an Intelligent Low Level Radio Frequency Circuit or ILLRF, suitable for most AVF cyclotron accelerators, is designed using a beam monitoring device and narrow band tunable band-pass filter. In this design, the RF phase detection does not need signal processing by a microcontroller.

Design analysis report for the 244-AR vault Interim Stabilization interior transfer system

International Nuclear Information System (INIS)

CARLSON, A.B.

2002-01-01

The purpose of this calculation note is to verify that the 244-AR Vault Interior Transfer System piping installed in the vault meets ASME B31.3 code requirements. This calculation also evaluates the pipe support loads

A COMPARISON OF UPPER-EXTREMITY REACTION FORCES BETWEEN THE YURCHENKO VAULT AND FLOOR EXERCISE

Directory of Open Access Journals (Sweden)

Matthew Kirk Seeley

2005-06-01

Full Text Available The purpose of this study was to examine reaction forces transmitted to the upper extremities of high-level gymnasts during the round-off phase of the Yurchenko vault. A secondary purpose of this study was to compare reaction forces during the Yurchenko vault to reaction forces observed in a tumbling pass during the floor exercise. Ten high-level, female gymnasts volunteered to participate. Conditions of the independent variable were the Yurchenko vault and floor exercise; dependent variables were peak vertical and peak anterior-posterior reaction forces. Each participant performed three trials of both conditions with the trail hand contacting a force platform. Vertical and anterior-posterior reaction forces, normalized to body weight, were greater (p < 0.05 during the round-off phase of the Yurchenko vault (2.38 than during the floor exercise round-off (2.15. Vertical reaction forces during the round-off phase of the Yurchenko vault and floor exercise round-off are similar to reaction forces transmitted to upper extremities during other gymnastic skills and ground reaction forces transmitted to lower extremities while running and walking at various speeds. Results of this study reveal a need for further research considering methods aimed at reducing reaction forces transmitted to the upper extremities during the Yurchenko vault and floor exercise.

Geochemical factors influencing vault design and layout

International Nuclear Information System (INIS)

Gascoyne, M.; Stroes-Gascoyne, S.; Sargent, F.P.

1995-01-01

The design and construction of a vault for used nuclear fuel in crystalline rock may be influenced by a number of geochemical factors. During the siting stage, information is needed regarding the rock type, heterogeneities in its composition and the mineralogy of permeable zones because these will cause variations in thermal conductivity, strength and radionuclide sorptive properties of the rock. These factors may affect decisions regarding depth of vault construction, tunnel dimensions and spacing of panels and waste containers. The decision on whether groundwaters are allowed to flow freely into a planned excavation may depend on measurements of their chemical compositions, microbiological contents and presence of hazardous or corrosive constituents. During site characterization, borehole drilling from the surface and subsequent hydraulic testing will introduce both chemical and microbiological contaminants that may further influence this decision. During vault construction, the geochemistry of the rock may cause changes to the characterization, design and construction of the vault. For example, high salinity fluids in micropores in the rock could prevent the use of radar surveys to detect fractures in the surrounding rock. High rock salinity may also cause unacceptably high total dissolved solids loadings in water discharged from the facility. Again, the presence of toxic, corrosive or radioactive constituents in inflowing groundwater may require grouting or, if inflow is needed for service operations, development of treatment facilities both above and below ground. In addition, the use of explosives will cause high organic and nitrate loadings in service water as well as the possible impregnation of these chemicals in the damaged wall-rock surrounding an excavation. These chemicals may remain despite cleaning efforts and act as nutrients to promote microbial activity in the post-closure phase. In the operational phase, further design and construction, changes

Cyclotron waves in plasma

International Nuclear Information System (INIS)

Lominadse, D.G.

1975-01-01

The book deals with fundamental physical concepts of the theory of cyclotron waves and cyclotron instabilities conditioned by the presence in plasma of direct or alternating electric currents passing in it perpendicularily to a magnetic field. A great variety of problems is considered connected with the linear theory of cyclotron oscillations in equilibrium and electron plasma of metals and semiconductors. Parametric excitations of electron cyclotron oscillations of plasma in an alternating electric field are studied. Particular attention is paid to the investigation of plasma turbulence arising as a result of development of cyclotron instabilities. Experimental data are discussed and compared with theoretical results

Cyclotrons: 1978

International Nuclear Information System (INIS)

Martin, J.A.

1978-01-01

A compilation is presented of the experimental facilities of the world's cyclotrons including history and status, staff and operation, research staff, target facilities, magnet, acceleration system, vacuum system, characteristic beams, beam properties, and a plan view of the facility for each cyclotron

A prediction model for the radiation safety management behavior of medical cyclotrons

Energy Technology Data Exchange (ETDEWEB)

Jung, Ji Hye; Han, Eun Ok [Daegu Health College, Daegu (Korea, Republic of); Kim, Ssang Tae [CareCamp Inc., Seoul (Korea, Republic of)

2008-06-15

This study attempted to provide reference materials for improving the behavior level in radiation safety managements by drawing a prediction model that affects the radiation safety management behavior because the radiation safety management of medical Cyclotrons, which can be used to produce radioisotopes, is an important factor that protects radiation caused diseases not only for radiological operators but average users. In addition, this study obtained follows results through the investigation applied from January 2 to January 30, 2008 for the radiation safety managers employed in 24 authorized organizations, which have already installed Cyclotrons, through applying a specific form of questionnaire in which the validity was guaranteed by reference study, site investigation, and focus discussion by related experts. The radiation safety management were configured as seven steps: step 1 is a production preparation step, step 2 is an RI production step, step 3 is a synthesis step, step 4 is a distribution step, step 5 is a quality control step, step 6 is a carriage container packing step, and step 7 is a transportation step. It was recognized that the distribution step was the most exposed as 15 subjects (62.5%), the items of 'the sanction and permission related works' and 'the guarantee of installation facilities and production equipment' were the most difficult as 9 subjects (37.5%), and in the trouble steps in such exposure, the item of 'the synthesis and distribution' steps were 4 times, respectively (30.8%). In the score of the behavior level in radiation safety managements, the minimum and maximum scores were 2.42 and 4.00, respectively, and the average score was 3.46 {+-} 0.47 out of 4. Prosperity and well-being programs in the behavior and job in radiation safety managements (r=0.529) represented a significant correlation statistically. In the drawing of a prediction model based on the factors that affected the behavior in

The subtle attractions of dry vault storage

International Nuclear Information System (INIS)

Ealing, C.J.

1993-01-01

Utilities in the United States of America, Scotland and Hungary have all adopted dry vault technology in their plans for spent fuel storage. This article looks at what makes dry storage an attractive option. (author)

The military health system's personal health record pilot with Microsoft HealthVault and Google Health.

Science.gov (United States)

Do, Nhan V; Barnhill, Rick; Heermann-Do, Kimberly A; Salzman, Keith L; Gimbel, Ronald W

2011-01-01

To design, build, implement, and evaluate a personal health record (PHR), tethered to the Military Health System, that leverages Microsoft® HealthVault and Google® Health infrastructure based on user preference. A pilot project was conducted in 2008-2009 at Madigan Army Medical Center in Tacoma, Washington. Our PHR was architected to a flexible platform that incorporated standards-based models of Continuity of Document and Continuity of Care Record to map Department of Defense-sourced health data, via a secure Veterans Administration data broker, to Microsoft® HealthVault and Google® Health based on user preference. The project design and implementation were guided by provider and patient advisory panels with formal user evaluation. The pilot project included 250 beneficiary users. Approximately 73.2% of users were Microsoft® HealthVault, and 81 (32.4%) selected Google® Health as their PHR of preference. Sample evaluation of users reflected 100% (n = 60) satisfied with convenience of record access and 91.7% (n = 55) satisfied with overall functionality of PHR. Key lessons learned related to data-transfer decisions (push vs pull), purposeful delays in reporting sensitive information, understanding and mapping PHR use and clinical workflow, and decisions on information patients may choose to share with their provider. Currently PHRs are being viewed as empowering tools for patient activation. Design and implementation issues (eg, technical, organizational, information security) are substantial and must be thoughtfully approached. Adopting standards into design can enhance the national goal of portability and interoperability.

Radioisotope production by reactors and cyclotrons in Japan

International Nuclear Information System (INIS)

Murakami, Yukio

1978-01-01

Present status of radioisotope production in Japan and the increasing demand from various fields are generally reviewed. Future problems associated with the shortage of economical supply are also discussed. The first half of this report is devoted to general review of the increasing demand for various radioisotopes from increasing number of users. The present status and future trends of the distribution of users of specific radioisotopes and their demands are shown. The remaining half of this report reviews the production with reactors and cyclotrons. The Japanese reactors producing radioisotopes are limited to low flux (10 13 ) research reactors at JAERI. Some problems associated with the improvement of availability and with the organizational structure are discussed. As for the production with cyclotrons, available facilities and the method of production are explained in detail. For clinical use, especially for the production of short lived radioisotopes, the advantage of a small special purpose cyclotron at each medical organization is emphasized. (Aoki, K.)

ROLE OF MESH REPAIR IN PELVIC ORGAN PROLAPSE, WITH PARTICULAR REFERENCE TO VAULT PROLAPSE & NULLIPAROUS PROLAPSE

Directory of Open Access Journals (Sweden)

Geeta Vandana Reddi

2017-12-01

Full Text Available BACKGROUND Pelvic organ prolapse is a common complaint in gynaecological practice. Nulliparous prolapse is seen in 2% of female population and vault prolapse in 0.5% following hysterectomy. Various surgical procedures have been described for the repair of vault prolapse e.g. transvaginal sacrospinous colpopexy, transabdominal sacral colpopexy, Le Forte's operation, colpoclesis, posterior intravaginal sling plasty etc. The introduction of synthetic mesh like Prolene, Mersilene for the repair of vault prolapse have the advantage of tensile strength. In nulliparous prolapse and uterovaginal prolapse also, the supports of uterus are weakened, so there seems to be a definite advantage of mesh repair over sling surgeries. MATERIALS AND METHODS A prospective study done in 50 patients with vault prolapse, Nulliparous prolapse and patients with UV prolapse who want to retain their menstrual and reproductive function were identified and repair of defects were done. 2 cases who underwent both hysterectomy and sacral colpopexy in two sittings were included in the study. They were followed up for a period of 6 weeks - 29 months. RESULTS In the present study, the mean age for vault prolapse was 52.14 years, mean parity was 3.36. Vault prolapses were found to be more common after abdominal hysterectomy 60.97% compared to vaginal 39.02%. Common indication for hysterectomy is pelvic organ prolapse followed by DUB in this study. The mean time between the hysterectomy and vault prolapse in this study was 5.46 years. Importance should be given to proper enterocoele repair and vault suspense time of primary surgery. In this study incidence of smoking in vault prolapse cases was 34.14% significant. In cases of sacral colpopexy for vault prolapse in this study there were no major mesh related complications and the cure rate was 97.5%. So, sacral colpopexy with prolene mesh i.e. abdominal mesh repair can be employed as the primary surgery for vault prolapse. The safety

Vault Safety and Inventory System users manual, PRIME 2350. Revision 1

International Nuclear Information System (INIS)

Downey, N.J.

1994-01-01

This revision is issued to request review of the attached document: VSIS User Manual, PRIME 2350, which provides user information for the operation of the VSIS (Vault Safety and Inventory System). It describes operational aspects of Prime 2350 minicomputer and vault data acquisition equipment. It also describes the User's Main Menu and menu functions, including REPORTS. Also, system procedures for the Prime 2350 minicomputer are covered

Vault Safety and Inventory System users manual, PRIME 2350. Revision 1

Energy Technology Data Exchange (ETDEWEB)

Downey, N.J.

1994-12-14

This revision is issued to request review of the attached document: VSIS User Manual, PRIME 2350, which provides user information for the operation of the VSIS (Vault Safety and Inventory System). It describes operational aspects of Prime 2350 minicomputer and vault data acquisition equipment. It also describes the User`s Main Menu and menu functions, including REPORTS. Also, system procedures for the Prime 2350 minicomputer are covered.

The mechanism of vault opening from the high resolution structure of the N-terminal repeats of MVP.

Science.gov (United States)

Querol-Audí, Jordi; Casañas, Arnau; Usón, Isabel; Luque, Daniel; Castón, José R; Fita, Ignasi; Verdaguer, Nuria

2009-11-04

Vaults are ubiquitous ribonucleoprotein complexes involved in a diversity of cellular processes, including multidrug resistance, transport mechanisms and signal transmission. The vault particle shows a barrel-shaped structure organized in two identical moieties, each consisting of 39 copies of the major vault protein MVP. Earlier data indicated that vault halves can dissociate at acidic pH. The crystal structure of the vault particle solved at 8 A resolution, together with the 2.1-A structure of the seven N-terminal domains (R1-R7) of MVP, reveal the interactions governing vault association and provide an explanation for a reversible dissociation induced by low pH. The structural comparison with the recently published 3.5 A model shows major discrepancies, both in the main chain tracing and in the side chain assignment of the two terminal domains R1 and R2.

LIBO - boosting medical cyclotron facilities for cancer therapy Exhibition LEPFest 2000

CERN Multimedia

2000-01-01

Length : Energy boost : From 62 to 200 MeVAccelerating gradient : 10 MeV/metreAccelerating frequency : 3 GHz Collaboration : CERN, INFN and University of Milan, INFN and University of Naples and TERA foundation Prototype test in 2001 : SC cyclotron Catania

The Study of 99mTc Production Using Medical Cyclotrons in Ukraine

Directory of Open Access Journals (Sweden)

Borys M. Bondar

2017-12-01

Conclusions. The obtained results showed satisfied 99mTс tracer yields and feasibility of further development of this method, which will significantly improve the efficiency of cyclotron installations.

GOTHIC analysis of post-accident hydrogen mixing behaviour in CANDU fuelling machine vault

International Nuclear Information System (INIS)

Yim, K.; Wong, R.C.; Fluke, R.J.

1997-01-01

The GOTHIC code was used to assess the post-accident hydrogen gas mixing patterns in a CANDU reactor containment and demonstrate the acceptability of Ontario Hydro Nuclear's hydrogen mitigation methods. The fuelling machine vault, being a small volume room containing major reactor piping, is the room of most concern with respect to hydrogen concentrations. Detailed three dimensional modelling of the gas mixing patterns in the fuelling machine vault was completed. Results showed that, even without forced air circulation, there is enough dispersion of hydrogen to other parts of containment to preclude the build-up of sensitive mixtures in the vault. For a brief time during the peak period of hydrogen release, hydrogen concentrations rise to close to the lower ignition limit in a small portion of the vault, but these hydrogen-steam-air mixtures are considered acceptable. Natural mixing alone is sufficient to preclude damaging hydrogen burns. (author)

Cyclotrons as mass spectrometers

International Nuclear Information System (INIS)

Clark, D.J.

1984-04-01

The principles and design choices for cyclotrons as mass spectrometers are described. They are illustrated by examples of cyclotrons developed by various groups for this purpose. The use of present high energy cyclotrons for mass spectrometry is also described. 28 references, 12 figures

Beyond BLASTing: Tertiary and Quaternary Structure Analysis Helps Identify Major Vault Proteins

Science.gov (United States)

Daly, Toni K.; Sutherland-Smith, Andrew J.; Penny, David

2013-01-01

We examine the advantages of going beyond sequence similarity and use both protein three-dimensional (3D) structure prediction and then quaternary structure (docking) of inferred 3D structures to help evaluate whether comparable sequences can fold into homologous structures with sufficient lateral associations for quaternary structure formation. Our test case is the major vault protein (MVP) that oligomerizes in multiple copies to form barrel-like vault particles and is relatively widespread among eukaryotes. We used the iterative threading assembly refinement server (I-TASSER) to predict whether putative MVP sequences identified by BLASTp and PSI Basic Local Alignment Search Tool are structurally similar to the experimentally determined rodent MVP tertiary structures. Then two identical predicted quaternary structures from I-TASSER are analyzed by RosettaDock to test whether a pair-wise association occurs, and hence whether the oligomeric vault complex is likely to form for a given MVP sequence. Positive controls for the method are the experimentally determined rat (Rattus norvegicus) vault X-ray crystal structure and the purple sea urchin (Strongylocentrotus purpuratus) MVP sequence that forms experimentally observed vaults. These and two kinetoplast MVP structural homologs were predicted with high confidence value, and RosettaDock predicted that these MVP sequences would dock laterally and therefore could form oligomeric vaults. As the negative control, I-TASSER did not predict an MVP-like structure from a randomized rat MVP sequence, even when constrained to the rat MVP crystal structure (PDB:2ZUO), thus further validating the method. The protocol identified six putative homologous MVP sequences in the heterobolosean Naegleria gruberi within the excavate kingdom. Two of these sequences are predicted to be structurally similar to rat MVP, despite being in excess of 300 residues shorter. The method can be used generally to help test predictions of homology via

An after-market, five-port vertical beam line extension for the PETtrace

Science.gov (United States)

Barnhart, T. E.; Engle, J. W.; Severin, G. W.; Valdovinos, H. F.; Gagnon, K.; Nickles, R. J.

2012-12-01

Most commercial cyclotrons intended for medical isotope production provide a limited number of beam ports crowded into a minimal vault space. Taking advantage of our new lab construction, we planned and installed a beam-line on port ♯2 of our GEMS PETtrace to bring beam to an additional 5 target positions. These are oriented in the vertical plane, with the downward directed beam well suited for molten target substrates.

CAS CERN Accelerator School: Cyclotrons, linacs and their applications. Proceedings

International Nuclear Information System (INIS)

Turner, S.

1996-01-01

These proceedings present the lectures given at the eighth specialized course organized by the CERN Accelerator School (CAS), the topic this time being 'Cyclotrons, Linacs and Their Applications'. Following an introductory lecture on linacs, the fundamental features of electron, ion and induction linacs are described together with their RF systems and particle sources. Cyclotrons are then introduced followed by details of their different types, their magnet and RF design, and their injection and extraction systems, with a glance towards exotic and possible future machines. Chapters are then presented on the use of linacs and cyclotrons for medical, fission, fusion and material applications, as well as for isotope production. Finally, descriptions of the design of a radioisotope facility, the matching of accelerators to their task and the computational tools used in their design are included. (orig.)

CAS CERN Accelerator School: Cyclotrons, linacs and their applications. Proceedings

Energy Technology Data Exchange (ETDEWEB)

Turner, S [ed.

1996-03-04

These proceedings present the lectures given at the eighth specialized course organized by the CERN Accelerator School (CAS), the topic this time being `Cyclotrons, Linacs and Their Applications`. Following an introductory lecture on linacs, the fundamental features of electron, ion and induction linacs are described together with their RF systems and particle sources. Cyclotrons are then introduced followed by details of their different types, their magnet and RF design, and their injection and extraction systems, with a glance towards exotic and possible future machines. Chapters are then presented on the use of linacs and cyclotrons for medical, fission, fusion and material applications, as well as for isotope production. Finally, descriptions of the design of a radioisotope facility, the matching of accelerators to their task and the computational tools used in their design are included. (orig.).

The TROVE module: a common element in Telomerase, Ro and Vault ribonucleoproteins.

Science.gov (United States)

Bateman, Alex; Kickhoefer, Valerie

2003-10-16

Ribonucleoproteins carry out a variety of important tasks in the cell. In this study we show that a number of these contain a novel module, that we speculate mediates RNA-binding. The TROVE module--Telomerase, Ro and Vault module--is found in TEP1 and Ro60 the protein components of three ribonucleoprotein particles. This novel module, consisting of one or more domains, may be involved in binding the RNA components of the three RNPs, which are telomerase RNA, Y RNA and vault RNA. A second conserved region in these proteins is shown to be a member of the vWA domain family. The vWA domain in TEP1 is closely related to the previously recognised vWA domain in VPARP a second component of the vault particle. This vWA domain may mediate interactions between these vault components or bind as yet unidentified components of the RNPs. This work suggests that a number of ribonucleoprotein components use a common RNA-binding module. The TROVE module is also found in bacterial ribonucleoproteins suggesting an ancient origin for these ribonucleoproteins.

Data Vaults: Database Technology for Scientific File Repositories

NARCIS (Netherlands)

M.G. Ivanova (Milena); M.L. Kersten (Martin); S. Manegold (Stefan); Y. Kargin (Yagiz)

2013-01-01

htmlabstractCurrent data-management systems and analysis tools fail to meet scientists’ data-intensive needs. A "data vault" approach lets researchers effectively and efficiently explore and analyze information.

On the tenth value distance of the photon field along the maze of high-energy linear accelerator vaults.

Science.gov (United States)

Han, Zhaohui; Chin, Lee M

2018-03-01

There is a wide range in the reported photon tenth value distance (TVD) in the maze of high-energy linear accelerator vaults. In order to gain insight into the appropriate use of the TVD value during door design, we performed measurements of the photon dose in the maze of four vaults. In addition, our study represents the first to describe a scenario where an inner borated polyethylene (BPE) door for neutron shielding is installed in the maze downstream to Point A, the point on the maze centerline that is just visible from the isocenter. The measurements were made along the maze centerline at 1 m above the floor. In all cases, the accelerator operated at a nominal energy of 15 MV. Of the four vaults, three were equipped with an inner BPE door at a distance of 1.0-2.1 m downstream to Point A. The door was made of 10.16 cm (4″) BPE sandwiched between two 0.635 cm (1/4″) steel face plates. The photon dose in the maze without a BPE door decreases exponentially with a characteristic TVD of 6 m beyond a distance of 2.5 m from Point A. The presence of a BPE door in an identical vault not only reduces the photon intensity in the maze by about an order of magnitude, but also softens the energy spectrum with a shortened TVD of 4.7 m, significantly lessening the shielding burden at the outer maze entrance. In contrast to the common use of Point A as the reference point to specify distance, the photon dose in the maze with a BPE door located downstream to Point A can be satisfactorily described as exponential functions of the distance measured from the door, which shows good consistency among the three vaults of different room parameters. © 2018 The Authors. Journal of Applied Clinical Medical Physics published by Wiley Periodicals, Inc. on behalf of American Association of Physicists in Medicine.

Preliminary modelling study of geochemical interactions between a used-fuel disposal vault and the surrounding geosphere

International Nuclear Information System (INIS)

McMurry, J.

1995-10-01

In the Environmental Impact Statement (EIS) and the related documents that describe the Canadian nuclear fuel waste disposal concept (AECL 1994), it has been assumed that a disposal vault would have no significant geochemical impact on the geosphere, and so no such effects were included explicitly in the postclosure assessment model. The purpose of this study was to estimate the general magnitude and significance of vault-induced geochemical changes over an expected range of temperatures. The results of the preliminary modelling are used broadly to evaluate the implications of these changes for the migration of radionuclides through the geosphere. The geochemical modelling program PHREEQE was used to calculate the changes in mineral solubilities that would result from the transfer of aqueous species from the vault to the geosphere or that would result from groundwater-granite interactions enhanced by vault-derived elevated temperatures. Twelve representative vault water compositions, derived from predicted interactions with buffer material and backfill over a range of temperatures up to 95 deg C, were used in the modelling. For the conditions modelled it was determined that the interactions of the geosphere with dissolved vault constituents, and the relatively modest maximum increase in groundwater temperature produced by a vault, would have a limited impact on the geosphere. The conclusions of this preliminary study are qualified by some of the simplifying assumptions used in the modelling. More realistic modelling of natural systems requires a more detailed representation of water-solid interactions with a variety of vault materials at elevated temperatures. (author) 48 refs., 13 tabs, 4 figs

Design study of an ultra-compact superconducting cyclotron for isotope production

Science.gov (United States)

Smirnov, V.; Vorozhtsov, S.; Vincent, J.

2014-11-01

A 12.5 MeV, 25 μA, proton compact superconducting cyclotron for medical isotope production has been designed and is currently in fabrication. The machine is initially aimed at producing 13N ammonia for Positron Emission Tomography (PET) cardiology applications. With an ultra-compact size and cost-effective price point, this system will offer clinicians unprecedented access to the preferred radiopharmaceutical isotope for cardiac PET imaging. A systems approach that carefully balanced the subsystem requirements coupled to precise beam dynamics calculations was followed. The system is designed to irradiate a liquid target internal to the cyclotron and to minimize the need for radiation shielding. The main parameters of the cyclotron, its design, and principal steps of the development work are presented here.

The disposal of Canada's nuclear fuel waste: the vault model for postclosure assessment

International Nuclear Information System (INIS)

Johnson, L.H.; LeNeveu, D.M.; Shoesmith, D.W.; Oscarson, D.W.; Gray, M.N.; Lemire, R.J.; Garisto, N.C.

1994-01-01

The concept for disposal of Canada's nuclear fuel waste involves emplacing the waste in a vault excavated at a depth of 500 to 1000 m in plutonic rock of thc Canadian Shield. The solid waste would be isolated from the biosphere by a multibarrier system consisting of engineered barriers, including corrosion-resistant containers and clay- and cement-based sealing materials, and the natural barrier provided by the massive geological formation. The technical feasibility of this concept, and its impact on the environment and human health, is being documented in an Environmental Impact Statement (EIS) that will be submitted for review under the federal Environmental Assessment and Review Process. The present report is one of nine EIS primary references. The report describes the vault model, which is used to calculate the time-dependent release of radioactive and non-radioactive contaminants from the engineered barrier system (vault) into the surrounding rock (geosphere). The model calculations presented are for a specific reference vault design that comprises used CANDU (CANada Deuterium Uranium) fuel bundles in Grade-2 titanium containers, which would be emplaced in boreholes in the floor of a mined excavation located at a depth of 500 m in plutonic rock. The containers would be surrounded by a compacted buffer material that is a mixture of 50 wt. % sand and 50 wt. % bentonite. Disposal rooms and tunnels would be sealed with a layer of backfill mixture composed of 25 % glacial lake clay and 75% crushed granite and an overlying layer of buffer material. The vault model is a computer code that calculates the failure times of titanium containers, the rate of release of radionuclides from used-fuel bundles into the groundwater that would flow into the failed containers, and the rate of transport of radionuclides from the fuel through the groundwater-saturated buffer and backfill materials and into the surrounding rock. The vault model uses distributed or probabilistic

First experiences with electrochemical in-situ desalination of bricks in a church vault construction

DEFF Research Database (Denmark)

Rörig-Dalgaard, Inge

2012-01-01

was chosen. Salt profiles from three different bricks within this area clarified two bricks with low ion contents and one with a high ion content which is representative for church vault constructions. The idea of using a climate chamber for dissolution of present salts for minimizing additional water supply...... problematic in relation to church vault constructions with murals as the surface deterioration can result in loss of valuable cultural heritage. An electrochemical method has been investigated with focus on possible use for desalination of salt loaded vault constructions with murals in laboratory scale...

Vault lining for 340 waste handling facility, 300 area

International Nuclear Information System (INIS)

Hollenbeck, R.G.

1997-01-01

Coating systems by Protection Enterprises, Ameron, Carboline, and Steelcote were evaluated. Each manufacturer has a coating system that is acceptable for use in the 340 Vault (see Appendix A). The choice of which system to use will be made after in-place adhesion tests are complete. The Protection Enterprises coating has the greatest potential for acceptable adhesion with minimal surface preparation. Total project cost for engineering and construction is $1,220,000 including 50% for contingency (see Appendix B). If the existing vault coverblock access hatch can satisfy entry requirements, $95,000 can be saved from the removal of coverblocks and the erection and disassembly of the greenhouse

Vault submodel for the second interim assessment of the Canadian concept for nuclear fuel waste disposal

International Nuclear Information System (INIS)

LeNeveu, D.M.

1986-02-01

The consequences to man and the environment of the disposal of nuclear fuel waste are being studied within the Canadian Nuclear Fuel Waste Management Program. The concept being assessed is that of a sealed disposal vault at a depth of 1000 m in plutonic rock in the Canadian Shield. To determine the consequences, the vault and its environment are simulated using a SYstem Variability Analysis Code (SYVAC), a stochastic model of the disposal system. SYVAC contains three submodels that represent the three major parts of the disposal system: the vault, the geosphere and the biosphere. This report documents the conceptual and mathematical framework of the vault submodel

Architecture - re-Construction - Geometry: a knowledge path applied to the study of Plantery's vaults in Turin

Directory of Open Access Journals (Sweden)

Roberta Spallone

2012-06-01

Full Text Available Plantery's vaults, by the name of the architect working in Turin since first years of '700, are composed by a main vault intersected by some axial and angular secondary vaults. Plantery's vaults allow to roof over unitary spaces obtaining effects of lightness also by small rises. Their diffusion, up to the '80s of the century, in boardrooms as palaces halls, and the richness of variations on the theme, justifies a research, that makes use of survey and digital modeling. This research is focused on the relationships between geometric models and built architecture, connected by use of materials, construction techniques and decorative styles.

Association of lens vault with narrow angles among different ethnic groups.

Science.gov (United States)

Lee, Roland Y; Huang, Guofu; Cui, Qi N; He, Mingguang; Porco, Travis C; Lin, Shan C

2012-06-01

To compare lens vault between open-angle and narrow-angle eyes in African-, Caucasian-, Hispanic-, Chinese- and Filipino-Americans. In this prospective study, 436 patients with open angle and narrow angle based on the Shaffer gonioscopic grading classification underwent anterior-segment optical coherence tomography. The Zhongshan Angle Assessment Program was used to calculate lens vault. The narrow-angle group included 32 Chinese-Americans, 22 Filipino-Americans, 26 African-Americans, 24 Hispanic-Americans and 73 Caucasian-Americans. The open-angle group included 56 Chinese-Americans, 29 Filipino-Americans, 45 African-Americans, 27 Hispanic-Americans and 102 Caucasian-Americans. Linear mixed effect regression models, accounting for the use of both eyes and adjusting for age, sex, pupil diameter and spherical equivalent, were used to test for the ethnicity and angle coefficients. Tukey's multiple comparison test was used for pairwise comparisons among the open-angle racial groups. Significant difference in lens vault was found among the open-angle racial groups (P = 0.022). For the open-angle patients, mean values for the lens vault measurements were 265 ± 288 µm for Chinese-Americans, 431 ± 248 µm for Caucasian-Americans, 302 ± 213 µm for Filipino-Americans, 304 ± 263 µm for Hispanic-Americans and 200 ± 237 µm for African-Americans. Using Tukey's multiple comparison for pairwise comparisons among the open-angle racial groups, a significant difference was found between African-American and Caucasian-Americans groups (P values for the rest of the pairwise comparisons were not statistically significant. No significant difference was found among the narrow-angle racial groups (P = 0.14). Comparison between the open angle and narrow angle within each racial group revealed significant difference for all racial groups (P < 0.05). Among all the ethnicities included in this study, narrow-angle eyes have greater lens vault compared to open

The TROVE module: A common element in Telomerase, Ro and Vault ribonucleoproteins

Directory of Open Access Journals (Sweden)

Bateman Alex

2003-10-01

Full Text Available Abstract Background Ribonucleoproteins carry out a variety of important tasks in the cell. In this study we show that a number of these contain a novel module, that we speculate mediates RNA-binding. Results The TROVE module – Telomerase, Ro and Vault module – is found in TEP1 and Ro60 the protein components of three ribonucleoprotein particles. This novel module, consisting of one or more domains, may be involved in binding the RNA components of the three RNPs, which are telomerase RNA, Y RNA and vault RNA. A second conserved region in these proteins is shown to be a member of the vWA domain family. The vWA domain in TEP1 is closely related to the previously recognised vWA domain in VPARP a second component of the vault particle. This vWA domain may mediate interactions between these vault components or bind as yet unidentified components of the RNPs. Conclusions This work suggests that a number of ribonucleoprotein components use a common RNA-binding module. The TROVE module is also found in bacterial ribonucleoproteins suggesting an ancient origin for these ribonucleoproteins.

Survey and assessment of radioactive waste management facilities in the United States. Section 2.5. Air-cooled vault storage facilities

International Nuclear Information System (INIS)

1986-01-01

There are two basic types of air-cooled vaults for the storage of spent nuclear fuel or vitrified HLRW. The two types, differentiated by the method of air cooling used, are the open-vault concept and the closed-vault concept. The following aspects of these air-cooled vault storage facility concepts are discussed: description and operation of facilities; strucutral design considerations and analysis; nuclear design considerations and analyses; vault environmental design considerations; unique design features; and accident analysis

Radiation survey of first Hi-Art II Tomotherapy vault design in India

International Nuclear Information System (INIS)

Kinhikar, Rajesh A.; Jamema, S.V.; Pai, Rajeshree; Sharma, P.K. Dash; Deshpande, Deepak D.

2009-01-01

A vault as per government-regulation compliance with adequate shielding needs was designed and constructed for Hi-Art II Tomotherapy machine being the first in India. Radiation measurements around this Tomotherapy treatment vault were carried out to check the shielding adequacy of the source housing and the vault. It was mandatory to get this un-conventional machine 'Type Approved' by Atomic Energy Regulatory Board (AERB) in India. The aim of this paper was to report on the radiation levels measured during the radiation survey carried out for this machine. The radiation levels in and around the vault were measured for stationary as well as rotational treatment procedures with the largest open field size (5 cm x 40 cm) at the isocenter with and without scattering medium. The survey was performed at three locations near each wall surrounding the vault as well. The leakage radiation from the source housing was measured both in the patient plane outside the treatment field and one meter distance from the source outside the patient plane. The radiation levels both for stationary as well as rotational procedures were within 1 mR/h. No significance difference was observed in the radiation levels measured for rotational procedures with and without scattering medium. The leakage radiation in the patient plane was found to be 0.04% (Tolerance 0.2%), while the head leakage was 0.007% (Tolerance 0.5%) of the dose rate at the isocenter. The treatment delivery with Tomotherapy does play safe radiation levels around the installation layout and also passes the leakage criteria as well.

An after-market, five-port vertical beam line extension for the PETtrace

Energy Technology Data Exchange (ETDEWEB)

Barnhart, T. E.; Engle, J. W.; Severin, G. W.; Valdovinos, H. F.; Gagnon, K.; Nickles, R. J. [Department of Medical Physics, University of Wisconsin, Madison, WI (United States); Los Alamos National Lab, Los Alamos, NM (United States); Hevesy Laboratory, Danish Technical University, Riso (Denmark); Department of Medical Physics, University of Wisconsin, Madison, WI (United States); Department of Radiology, University of Washington, Seattle, WA (United States); Department of Medical Physics, University of Wisconsin, Madison, WI (United States)

2012-12-19

Most commercial cyclotrons intended for medical isotope production provide a limited number of beam ports crowded into a minimal vault space. Taking advantage of our new lab construction, we planned and installed a beam-line on port Music-Sharp-Sign 2 of our GEMS PETtrace to bring beam to an additional 5 target positions. These are oriented in the vertical plane, with the downward directed beam well suited for molten target substrates.

Skull morphometry and vault sutures of Myrmecophaga tridactyla and Tamandua tetradactyla

Directory of Open Access Journals (Sweden)

Camila M. de S. Hossotani

2017-10-01

Full Text Available ABSTRACT This study aimed to examine the relationship between skull size and the level of cranial vault suture closure. A total of 50 Myrmecophaga tridactyla Linnaeus, 1758 and 178 Tamandua tetradactyla Linnaeus, 1758 skulls were analyzed in relation to 18 skull dimensions. The skulls were grouped into three levels of suture closure: no sutures closed (level 0, one or all the fallowing sutures closed: interfrontalis, sagitalis and coronalis (level 1 and all sutures closed (level 2. The results indicated that among the 18 variables measured, 17 showed significant differences (p ≤ 0.01 between level 0 and level 1 skulls of T. tetradactyla; as well as between level 0 and level 1, and level 0 and level 2 skulls of M. tridactyla. M. tridactyla level 1 and level 2 had no significant difference among any of the 18 dimensions. The foramen magnum height in both species showed no significant difference (p > 0.05 among any suture categories. In principle, suture closure level and cranial dimensions are related. The specimens with larger cranial dimensions showed greater number of cranial vault sutures closed for both species of anteaters. Tamandua tetradactyla and M. tridactyla specimens with none of the cranial vault suture closed have a foramen magnum height similar to those with cranial vault suture closed.

The cyclotron laboratory and the RFQ accelerator in Bern

International Nuclear Information System (INIS)

Braccini, S.; Ereditato, A.; Kreslo, I.; Nirkko, M.; Weber, M.; Scampoli, P.; Bremen, K. von

2013-01-01

Two proton accelerators have been recently put in operation in Bern: an 18 MeV cyclotron and a 2 MeV RFQ linac. The commercial IBA 18/18 cyclotron, equipped with a specifically conceived 6 m long external beam line ending in a separate bunker, will provide beams for routine 18-F and other PET radioisotope production as well as for novel detector, radiation biophysics, radioprotection, radiochemistry and radiopharmacy developments. The accelerator is embedded into a complex building hosting two physics laboratories and four Good Manufacturing Practice (GMP) laboratories. This project is the result of a successful collaboration between the Inselspital, the University of Bern and private investors, aiming at the constitution of a combined medical and research centre able to provide the most cutting-edge technologies in medical imaging and cancer radiation therapy. The cyclotron is complemented by the RFQ with the primary goals of elemental analysis via Particle Induced Gamma Emission (PIGE), and the detection of potentially dangerous materials with high nitrogen content using the Gamma-Resonant Nuclear Absorption (GRNA) technique. In this context, beam instrumentation devices have been developed, in particular an innovative beam profile monitor based on doped silica fibres and a setup for emittance measurements using the pepper-pot technique. On this basis, the establishment of a proton therapy centre on the campus of the Inselspital is in the phase of advanced study

The cyclotron laboratory and the RFQ accelerator in Bern

Energy Technology Data Exchange (ETDEWEB)

Braccini, S.; Ereditato, A.; Kreslo, I.; Nirkko, M.; Weber, M. [Albert Einstein Center for Fundamental Physics, Laboratory for High Energy Physics (LHEP), University of Bern, Sidlerstrasse 5, CH-3012 Bern (Switzerland); Scampoli, P. [Albert Einstein Center for Fundamental Physics, Laboratory for High Energy Physics (LHEP), University of Bern, Sidlerstrasse 5, CH-3012 Bern, Switzerland and Department of Physical Sciences, University Federico II, Via Cintia, I-60126 Napoli (Italy); Bremen, K. von [SWAN Isotopen AG, Inselspital, CH-3010 Bern (Switzerland)

2013-07-18

Two proton accelerators have been recently put in operation in Bern: an 18 MeV cyclotron and a 2 MeV RFQ linac. The commercial IBA 18/18 cyclotron, equipped with a specifically conceived 6 m long external beam line ending in a separate bunker, will provide beams for routine 18-F and other PET radioisotope production as well as for novel detector, radiation biophysics, radioprotection, radiochemistry and radiopharmacy developments. The accelerator is embedded into a complex building hosting two physics laboratories and four Good Manufacturing Practice (GMP) laboratories. This project is the result of a successful collaboration between the Inselspital, the University of Bern and private investors, aiming at the constitution of a combined medical and research centre able to provide the most cutting-edge technologies in medical imaging and cancer radiation therapy. The cyclotron is complemented by the RFQ with the primary goals of elemental analysis via Particle Induced Gamma Emission (PIGE), and the detection of potentially dangerous materials with high nitrogen content using the Gamma-Resonant Nuclear Absorption (GRNA) technique. In this context, beam instrumentation devices have been developed, in particular an innovative beam profile monitor based on doped silica fibres and a setup for emittance measurements using the pepper-pot technique. On this basis, the establishment of a proton therapy centre on the campus of the Inselspital is in the phase of advanced study.

Experimental modelling of core debris dispersion from the vault under a PWR pressure vessel. Pt. 2

International Nuclear Information System (INIS)

Rose, P.W.

1987-12-01

In previous experiments, done on a 1/25 scale model in Perspex of the vault under a PWR pressure vessel, the instrument tubes support structure built into the vault was not included. It consists of a number of grids made up of fairly massive steel girders. These have now been added to the model and experiments performed using water to simulate molten core debris assumed to have fallen on to the vault floor and high-pressure air to simulate the discharge of steam or gas from the assumed breach at the bottom of the pressure vessel. The results show that the tubes support structure considerably reduces the carry-over of liquid via the vault access shafts. (author)

Disruption of the murine major vault protein (MVP/LRP) gene does not induce hypersensitivity to cytostatics.

Science.gov (United States)

Mossink, Marieke H; van Zon, Arend; Fränzel-Luiten, Erna; Schoester, Martijn; Kickhoefer, Valerie A; Scheffer, George L; Scheper, Rik J; Sonneveld, Pieter; Wiemer, Erik A C

2002-12-15

Vaults are ribonucleoprotein particles with a distinct structure and a high degree of conservation between species. Although no function has been assigned to the complex yet, there is some evidence for a role of vaults in multidrug resistance. To confirm a direct relation between vaults and multidrug resistance, and to investigate other possible functions of vaults, we have generated a major vault protein (MVP/lung resistance-related protein) knockout mouse model. The MVP(-/-) mice are viable, healthy, and show no obvious abnormalities. We investigated the sensitivity of MVP(-/-) embryonic stem cells and bone marrow cells derived from the MVP-deficient mice to various cytostatic agents with different mechanisms of action. Neither the MVP(-/-) embryonic stem cells nor the MVP(-/-) bone marrow cells showed an increased sensitivity to any of the drugs examined, as compared with wild-type cells. Furthermore, the activities of the ABC-transporters P-glycoprotein, multidrug resistance-associated protein and breast cancer resistance protein were unaltered on MVP deletion in these cells. In addition, MVP wild-type and deficient mice were treated with the anthracycline doxorubicin. Both groups of mice responded similarly to the doxorubicin treatment. Our results suggest that MVP/vaults are not directly involved in the resistance to cytostatic agents.

The Application of Carbon Composites in the Rehabilitation of Historic Baroque Vaults

OpenAIRE

Jiří Witzany; Jiří Brožovský; Tomáš Čejka; Klára Kroftová; Jan Kubát; Daniel Makovička; Radek Zigler

2015-01-01

The stabilization and reinforcement of damaged barrel vaults with lunettes over an arcaded walk, applying composite strips based on high-strength carbon fibers and epoxy resin, was performed during the restoration of a historic monastery. The application of reinforcing composite strips in the soffit of damaged barrel vaults was preceded by relatively extensive experimental research and theoretical analyses. This method significantly reduces the interventions into and the degradation of the or...

Seismic analysis of the mirror fusion test facility shielding vault

International Nuclear Information System (INIS)

Gabrielsen, B.L.; Tsai, K.

1981-04-01

This report presents a seismic analysis of the vault in Building 431 at Lawrence Livermore National Laboratory which houses the mirror Fusion Test Facility. The shielding vault structure is approximately 120 ft long by 80 ft wide and is constructed of concrete blocks approximately 7 x 7 x 7 ft. The north and south walls are approximately 53 ft high and the east wall is approximately 29 ft high. These walls are supported on a monolithic concrete foundation that surrounds a 21-ft deep open pit. Since the 53-ft walls appeared to present the greatest seismic problem they were the first investigated

Hazard Evaluation for 244-CR Vault

Energy Technology Data Exchange (ETDEWEB)

GRAMS, W.H.

1999-08-19

This document presents the results of a hazards identification and evaluation performed on the 244-CR Vault to close a USQ (USQ No.TF-98-0785, Potential Inadequacy in Authorization Basis (PIAB): To Evaluate Miscellaneous Facilities Listed In HNF-2503 And Not Addressed In The TWRS Authorization Basis) that was generated as part of an evaluation of inactive TWRS facilities.

Hazard Evaluation for 244-CR Vault

International Nuclear Information System (INIS)

GRAMS, W.H.

1999-01-01

This document presents the results of a hazards identification and evaluation performed on the 244-CR Vault to close a USQ (USQ No.TF-98-0785, Potential Inadequacy in Authorization Basis (PIAB): To Evaluate Miscellaneous Facilities Listed In HNF-2503 And Not Addressed In The TWRS Authorization Basis) that was generated as part of an evaluation of inactive TWRS facilities

PHASE II VAULT TESTING OF THE ARGONNE RFID SYSTEM

Energy Technology Data Exchange (ETDEWEB)

Willoner, T.; Turlington, R.; Koenig, R.

2012-06-25

The U.S. Department of Energy (DOE) (Environmental Management [EM], Office of Packaging and Transportation [EM-45]) Packaging and Certification Program (DOE PCP) has developed a Radio Frequency Identification (RFID) tracking and monitoring system, called ARG-US, for the management of nuclear materials packages during transportation and storage. The performance of the ARG-US RFID equipment and system has been fully tested in two demonstration projects in April 2008 and August 2009. With the strong support of DOE-SR and DOE PCP, a field testing program was completed in Savannah River Site's K-Area Material Storage (KAMS) Facility, an active Category I Plutonium Storage Facility, in 2010. As the next step (Phase II) of continued vault testing for the ARG-US system, the Savannah River Site K Area Material Storage facility has placed the ARG-US RFIDs into the 910B storage vault for operational testing. This latest version (Mark III) of the Argonne RFID system now has the capability to measure radiation dose and dose rate. This paper will report field testing progress of the ARG-US RFID equipment in KAMS, the operability and reliability trend results associated with the applications of the system, and discuss the potential benefits in enhancing safety, security and materials accountability. The purpose of this Phase II K Area test is to verify the accuracy of the radiation monitoring and proper functionality of the ARG-US RFID equipment and system under a realistic environment in the KAMS facility. Deploying the ARG-US RFID system leads to a reduced need for manned surveillance and increased inventory periods by providing real-time access to status and event history traceability, including environmental condition monitoring and radiation monitoring. The successful completion of the testing program will provide field data to support a future development and testing. This will increase Operation efficiency and cost effectiveness for vault operation. As the next step

Phase II Vault Testing of the Argonne RFID System

International Nuclear Information System (INIS)

Willoner, T.; Turlington, R.; Koenig, R.

2012-01-01

The U.S. Department of Energy (DOE) (Environmental Management (EM), Office of Packaging and Transportation (EM-45)) Packaging and Certification Program (DOE PCP) has developed a Radio Frequency Identification (RFID) tracking and monitoring system, called ARG-US, for the management of nuclear materials packages during transportation and storage. The performance of the ARG-US RFID equipment and system has been fully tested in two demonstration projects in April 2008 and August 2009. With the strong support of DOE-SR and DOE PCP, a field testing program was completed in Savannah River Site's K-Area Material Storage (KAMS) Facility, an active Category I Plutonium Storage Facility, in 2010. As the next step (Phase II) of continued vault testing for the ARG-US system, the Savannah River Site K Area Material Storage facility has placed the ARG-US RFIDs into the 910B storage vault for operational testing. This latest version (Mark III) of the Argonne RFID system now has the capability to measure radiation dose and dose rate. This paper will report field testing progress of the ARG-US RFID equipment in KAMS, the operability and reliability trend results associated with the applications of the system, and discuss the potential benefits in enhancing safety, security and materials accountability. The purpose of this Phase II K Area test is to verify the accuracy of the radiation monitoring and proper functionality of the ARG-US RFID equipment and system under a realistic environment in the KAMS facility. Deploying the ARG-US RFID system leads to a reduced need for manned surveillance and increased inventory periods by providing real-time access to status and event history traceability, including environmental condition monitoring and radiation monitoring. The successful completion of the testing program will provide field data to support a future development and testing. This will increase Operation efficiency and cost effectiveness for vault operation. As the next step (Phase

The potential for microbial life in a Canadian high-level nuclear fuel waste disposal vault

International Nuclear Information System (INIS)

Stroes-Gascoyne, S.

1989-12-01

Recent studies have concluded that microbial contamination of a nuclear fuel waste disposal vault is inevitable. Factors that will affect the development of substantial population of micro-organisms include: physiological tolerance of microbes; fluid movement in a vault; availability of nutrients; and availability of energy sources. It is difficult to resolve whether microbial growth will either positively or negatively affect the performance of a vault. One of the necessary steps towards ultimately answering this question is to assess the potential for microbial growth in a disposal vault, based on a nutrient and energy budget. This report gives a quantitative (but conservative) inventory of nutrients and potential energy sources present in a Canadian nuclear fuel waste vault, which hypothetically could support the growth of micro-organisms. Maximum population densities are calculated based on these inventories and assuming that all conditions for microbial growth are optimal, although this will certainly not be the case. Laboratory studies under the vault-relevant conditions are being performed to put realistic boundaries on the calculated numbers. Initial results from these studies, combined with data from a natural analogue site indicate that the calculated population densities could be overestimated by four to five orders of magnitude. Limited data show no effect of the presence of microbes on the transport of Tc, I, and Sr in backfill sand columns. Additional work is needed to address transport effects on buffer and backfill clay columns

Compact superconducting 250 MeV proton cyclotron for the PSI PROSCAN proton therapy project

International Nuclear Information System (INIS)

Schillo, M.; Geisler, A.; Hobl, A.; Klein, H.U.; Krischel, D.; Meyer-Reumers, M.; Piel, C.; Blosser, H.; Kim, J.-W.; Marti, F.; Vincent, J.; Brandenburg, S.; Beijers, J.P.M.

2001-01-01

A cyclotron for proton therapy has to fulfill many requirements set by the specific operational and safety needs of a medical facility and the medical environment. These are for instance high extraction efficiency, high availability and reliability, simple and robust operation. ACCEL Instruments GmbH has refined the design concept of a medical cyclotron for the PSI PROSCAN project with the objective to use this cyclotron as the standard accelerator in complete proton therapy facilities, which ACCEL intends to market. Starting from the design, we have carried out further detail clarifications, optimizations and adaptations to the needs of PSI. The work was performed in a collaboration between ACCEL, NSCL and KVI in view of the requirements from the PSI PROSCAN project. An overview on the design will be given touching on subjects such as the 3D structural analysis of the coil, detailed magnetic modeling for optimization of the inner region and the spiral, optimization of the RF power, optimization of the cryogenic design based on available cryocoolers instead of a liquefaction plant and Monte Carlo simulations to estimate the heat balance produced by neutrons at 4K components

Injection and extraction for cyclotrons

International Nuclear Information System (INIS)

Heikkinen, P.

1994-01-01

External ion sources for cyclotrons are needed for polarised and heavy ions. This calls for injection systems, either radial or axial. Radial injection is also needed when a cyclotron works as a booster after another cyclotron or a linear accelerator (usually tandem). Requirements for injection differ from separated sector cyclotrons where there is plenty of room to house inflectors and/or strippers, to superconducting cyclotrons where the space is limited by a small magnet gap, and high magnetic field puts other limitations to the inflectors. Several extraction schemes are used in cyclotrons. Stripping injection is used for H - and also for heavy ions where the q/m ratio is usually doubled. For other cases, electric and magnetic deflection has to be used. To increase the turn separation before the first deflector, both resonant and non-resonant schemes are used. In this lecture, external injection systems are surveyed and some rules to thumb for injection parameters are given. Extraction schemes are also reviewed. (orig.)

Radioactive air emissions notice of construction use of a portable exhauster at 244-AR vault. Revision 2

International Nuclear Information System (INIS)

Carrell, D.J.

1997-01-01

This document serves as a notice of construction (NOC), pursuant to the requirements of Washington Administrative Code (WAC) 246-247-060, and as a request for approval to construct, pursuant to 40 Code of Federal Regulations (CFR) 61.96, a portable exhauster at the 244-AR Vault. The exhauster would be used during air jetting of accumulated liquids from the cell sumps into the tanks and to make transfers among the tanks within the vault when needed. The 244-AR Vault is considered to be a double-contained receiver tank (OCRT) based on its functional characteristics, although it is not listed as one of the five designated DCRTs in the 200 Area Tank Farm systems. Process operations at the vault have been inactive since 1978 and the vault's two stacks have not operated since 1993. Since cessation of vault operations an extremely large amount of rain water and snow melt have accumulated in the cell sumps. The water level in the sumps is substantially above their respective operating levels and there is concern for leakage to the environment through containment failure due to corrosion from backed-up sump liquid. Active ventilation is required to provide contamination control during air jetting operations within the vault. It has been determined that it would not be cost effective to repair the existing exhaust systems to an operational condition; thus, a portable exhauster will be used to support the intermittent operations

Cleanup Verification Package for the 118-F-7, 100-F Miscellaneous Hardware Storage Vault

International Nuclear Information System (INIS)

Appel, M.J.

2006-01-01

This cleanup verification package documents completion of remedial action for the 118-F-7, 100-F Miscellaneous Hardware Storage Vault. The site consisted of an inactive solid waste storage vault used for temporary storage of slightly contaminated reactor parts that could be recovered and reused for the 100-F Area reactor operations

Cleanup Verification Package for the 118-F-7, 100-F Miscellaneous Hardware Storage Vault

Energy Technology Data Exchange (ETDEWEB)

M. J. Appel

2006-11-02

This cleanup verification package documents completion of remedial action for the 118-F-7, 100-F Miscellaneous Hardware Storage Vault. The site consisted of an inactive solid waste storage vault used for temporary storage of slightly contaminated reactor parts that could be recovered and reused for the 100-F Area reactor operations.

Focusing and bunching of ion beam in axial injection channel of IPHC cyclotron TR24

Science.gov (United States)

Adam, T.; Ivanenko, I.; Kazarinov, N.; Osswald, F.; Traykov, E.

2017-07-01

The CYRCe cyclotron (CYclotron pour la ReCherche et l’Enseignement) is used at IPHC (Institut Pluridisciplinaire Hubert Curien) for the production of radio-isotopes for diagnostics, medical treatments and fundamental research in radiobiology. The TR24 cyclotron produced and commercialized by ACSI (Canada) delivers a 16-25 MeV proton beam with intensity from few nA up to 500 μA. The solenoidal focusing instead of existing quadrupole one is proposed in this report. The changing of the focusing elements will give the better beam matching with the acceptance of the spiral inflector of the cyclotron. The parameters of the focusing solenoid are found. Additionally, the main parameters of the bunching system are evaluated in the presence of the beam space charge. This system consists of the buncher installed in the axial injection beam line of the cyclotron. The using of the grid-less multi harmonic buncher may increase the accelerated beam current and will give the opportunity to new proton beam applications.

Cyclotrons for isotope production

International Nuclear Information System (INIS)

Milton, B.F.; Stevenson, N.R.

1995-06-01

Cyclotrons continue to be efficient accelerators for radioisotope production. In recent years, developments in the accelerator technology have greatly increased the practical beam current in these machines while also improving the overall system reliability. These developments combined with the development of new isotopes for medicine and industry, and a retiring of older machines indicates a strong future for commercial cyclotrons. In this paper we will survey recent developments in the areas of cyclotron technology, and isotope production, as they relate to the new generation of commercial cyclotrons. We will also discuss the possibility of systems capable of extracted energies up to 100 MeV and extracted beam currents of up to 2.0 mA. (author). 6 refs., 2 tabs., 3 figs

An after-market, five-port vertical beam line extension for the PETtrace

DEFF Research Database (Denmark)

Barnhart, T. E.; Engle, J. W.; Severin, Gregory

2012-01-01

Most commercial cyclotrons intended for medical isotope production provide a limited number of beam ports crowded into a minimal vault space. Taking advantage of our new lab construction, we planned and installed a beam-line on port ♯2 of our GEMS PETtrace to bring beam to an additional 5 target...... positions. These are oriented in the vertical plane, with the downward directed beam well suited for molten target substrates. © 2012 American Institute of Physics...

Isochronous cyclotron data base description

International Nuclear Information System (INIS)

Kiyan, I.N.; Vorozhtsov, S.B.; Tarashkevich, R.

2004-01-01

The relational data base of the control parameters of the isochronous cyclotron, Isochronous Cyclotron Data Base (ICDB), is described. The relational data base under consideration, written in Transact SQL for the MS SQL Server 2000 with the use of MS Enterprise Manager and MS Query Analyzer, was installed on the server of the AIC144 isochronous cyclotron in Krakow, which operates under the control of the operating system MS Windows Server 2003 (Standard Edition). The interface of the data base under considerations is written in C++ with the use of Visual C++ .NET and is built in the Cyclotron Operator Help Program (COHP), which is used for modeling the operational modes of the isochronous cyclotron. Communication between the COHP and the relational data base is realised on the base of the Open Data Base Connectivity protocol. The relational data base of the control parameter of the isochronous cyclotron is intended: firstly, for systematization and automatic use of all measured and modelled magnetic field maps in the process of modeling the operational modes; secondly, for systematization and convenient access to the stored operational modes; thirdly, for simplifying the operator's work. The relational data base of the control parameter of the isochronous cyclotron reflects its physical structure and the logic of its operator's work. (author)

Accounting for cranial vault growth in experimental design.

Science.gov (United States)

Power, Stephanie M; Matic, Damir B; Holdsworth, David W

2014-05-01

Earlier studies have not accounted for continued growth when using the rat calvarial defect model to evaluate bone healing in vivo. The purpose of this study was: 1) to calculate rat cranial vault growth over time; and 2) to determine the effects of accounting for growth on defect healing. Bilateral parietal defects were created in 10 adult Wistar rats. Serial microscopic computerized tomography scans were performed. Bone mineral content (BMC) measured according to standard technique and repeated accounting for cranial growth over time was compared with the use of parametric and nonparametric tests. Cranial vault growth continued through 22 weeks of age, increasing 7.5% in width and 9.1% in length, and calvarial defects expanded proportionately. BMC was greater within defects accounting for growth 2-12 weeks postoperatively (P accounting for cranial growth given advances in serial imaging techniques. Crown Copyright © 2014. Published by Mosby, Inc. All rights reserved.

The Cyclotron Center of the Slovak Republic

International Nuclear Information System (INIS)

Podhorsky, D.; Ruzicka, J.; Macasek, F.; Makaiova, I.; Saro, S.; Kristiak, J.; Fulup, M.

2001-01-01

The Cyclotron Center of the Slovak Republic was established at the beginning of August 1999 - within the Slovak-Office of Standards, Metrology and Testing (SOSMT), in Bratislava, Slovak Republic. It will have two cyclotrons - a large heavy and light cyclotron DC-72, which will be constructed by the Joint Institute for Nuclear Research (JINR), Dubna, Russian Federation, and a small commercial light ion cyclotron IBA 18/9. The heavy ion source of the electron resonance type (DECRS-2M) will be used for low and medium energy experiments in physics. The small electron accelerator is planned for different applications, including improving the properties of plastics, increasing the resistance of cables to fire and temperature, the sterilization of medical disposables in the CC SR. The main purpose of the Cyclotron Center of the Slovak Republic (CC SR) is to catch the present approach and trends in the area of improving of inhabitants life and health quality using the progressive technology, which is introduced by bringing into practice of the physical equipment - accelerators, producing beams of high energy particles. Experts of nuclear physics and of the related branches have no experimental basis in Slovakia, as after dissolution of the former the Czech and Slovak Federal Republic all bigger nuclear equipment were left in the Czech Republic. The Slovak Republic is one of the European countries where cancer and cardiovascular diseases have a rapidly increasing tendency (the rate of new oncological cases is approximately 20,000/year at the population of 5 million inhabitants) - early diagnostics of population is necessary to be updated urgently. The Slovak Republic use a great part of electricity (about 60 %) from its own nuclear power stations and thus it is in need of education of rising generations of experts from different nuclear fields. The Government of the Slovak republic on June 18, 1996 approved the strategic aim of building up the Cyclotron Laboratory at the

The evolution of cerebellar tonsillar herniation after cranial vault remodeling surgery.

Science.gov (United States)

Leikola, J; Hukki, A; Karppinen, A; Valanne, L; Koljonen, V

2012-10-01

We sought to examine the pre- and postoperative changes of cerebellar tonsillar herniation by MR imaging in asymptomatic pediatric patients with nonsyndromic, single-suture craniosynostosis (N-SSSC), who underwent cranial vault remodeling surgery without suboccipital decompression. We required cerebellar tonsillar herniation through foramen magnum ≥3 mm for Chiari type I malformation (CMI). We hypothesized that the increase of intracranial volume by cranial vault remodeling would correct the asymptomatic CMI. We identified 9 patients among 121 N-SSSC children undergoing craniofacial surgery from January 2004 to October 2010 with CMI. However, two of them were excluded from the study due to missing postoperative MR images. In the final study population, six were males, five were scaphocephalic, while two were diagnosed with coronal synostosis. In four of the cases, the CMI was decreased in postoperative MR imaging varying from 6 to 12 mm. In three cases, the herniation remained stable. The median change of cerebellar tonsillar herniation was -6.5 mm. We conclude that asymptomatic patients with existing CMI may benefit from cranial vault remodeling surgery alone increasing the intracranial volume.

Fourier Transform Ion Cyclotron Resonance Mass Spectrometry at the Cyclotron Frequency.

Science.gov (United States)

Nagornov, Konstantin O; Kozhinov, Anton N; Tsybin, Yury O

2017-04-01

The phenomenon of ion cyclotron resonance allows for determining mass-to-charge ratio, m/z, of an ensemble of ions by means of measurements of their cyclotron frequency, ω c . In Fourier transform ion cyclotron resonance mass spectrometry (FT-ICR MS), the ω c quantity is usually unavailable for direct measurements: the resonant state is located close to the reduced cyclotron frequency (ω + ), whereas the ω c and the corresponding m/z values may be calculated via theoretical derivation from an experimental estimate of the ω + quantity. Here, we describe an experimental observation of a new resonant state, which is located close to the ω c frequency and is established because of azimuthally-dependent trapping electric fields of the recently developed ICR cells with narrow aperture detection electrodes. We show that in mass spectra, peaks close to ω + frequencies can be reduced to negligible levels relative to peaks close to ω c frequencies. Due to reduced errors with which the ω c quantity is obtained, the new resonance provides a means of cyclotron frequency measurements with precision greater than that achieved when ω + frequency peaks are employed. The described phenomenon may be considered for a development into an FT-ICR MS technology with increased mass accuracy for applications in basic research, life, and environmental sciences. Graphical Abstract ᅟ.

Building on TR-24 success. Advanced Cyclotron Systems Inc. launches a new cyclotron model

International Nuclear Information System (INIS)

Russell Watt; William Gyles; Alexander Zyuzin

2015-01-01

ACSI is designing a new 30 MeV cyclotron based on the TR-24. While minimizing changes from the proven TR-24, including maintaining the same outer dimensions, the energy of the cyclotron will be increased to 30 MeV, which will make it the most compact, non-superconducting, 30 MeV cyclotron design to date. Maximum beam current will match the TR-24 at 1 mA. With the size and footprint of a typical low energy PET cyclotron, this system will offer users a cost effective solution for a diversified facility capable of producing a wide spectrum of PET and SPECT radioisotopes for research and commercial distribution. (author)

Backfill formulations for a nuclear fuel waste disposal vault

International Nuclear Information System (INIS)

Yong, R.N.; Boonsinsuk, P.; Wong, G.; Ming, X.D.; Caporuscio, F.; Lytle, P.

1987-01-01

Atomic Energy of Canada Limited and Ontario Hydro are studying the concept of disposing of nuclear fuel wastes in a vault within the Canadian Shield. After nuclear waste containers have been emplaced in a vault, the vault will have to be backfilled permanently. A suitable backfill material should have low hydraulic conductivity and high radionuclide sorption capacity. The research was done with a goal of recommending a specification for formulating this backfill material. This report suggests that such a backfill material should be a mixture of coarse aggregates and swelling clay. Actual trial mixtures were prepared using crushed granite and natural Lake Agassiz clay. Various trial mixtures were subjected to constant-head permeability tests. The results indicate that the hydraulic conductivity of the aggregate-clay mixtures could be close to those of the clay (by itself) when the clay content was in the range of 25% or more. The resulting hydraulic conductivity of about 10 -10 m/s is considered to be low, especially since the maximum grain size is 19.1 mm. Selected mixtures were evaluated for free swell and swelling pressure, both of which increased with increasing clay content. When the clay content was 25%, the free swell was about 4%, compared with 6% for the 100% clay. The corresponding swelling pressure was about 16 kPa - in comparison to 48 kPa for the 100% clay. These results indicate that the proposed backfill material should contain about 25% clay, with a maximum grain size of 19.1 mm. The selected mixture was also tested to evaluate the effects of mixing methods, load-carrying capacity and compaction techniques suitable for the underground vault conditions. The proposed backfill material appeared to perform satisfactorily according to the criteria demanded. The backfill material proposed was further tested for its behaviour during water intake. The unsaturated hydraulic conductivity was found to be approximately 10 -10 m/s and the swelling pressure was

The Application of Carbon Composites in the Rehabilitation of Historic Baroque Vaults

Directory of Open Access Journals (Sweden)

Jiří Witzany

2015-12-01

Full Text Available The stabilization and reinforcement of damaged barrel vaults with lunettes over an arcaded walk, applying composite strips based on high-strength carbon fibers and epoxy resin, was performed during the restoration of a historic monastery. The application of reinforcing composite strips in the soffit of damaged barrel vaults was preceded by relatively extensive experimental research and theoretical analyses. This method significantly reduces the interventions into and the degradation of the original historic structure (surface application and is reversible.

A Protective Vaccine against Chlamydia Genital Infection Using Vault Nanoparticles without an Added Adjuvant.

Science.gov (United States)

Jiang, Janina; Liu, Guangchao; Kickhoefer, Valerie A; Rome, Leonard H; Li, Lin-Xi; McSorley, Stephen J; Kelly, Kathleen A

2017-01-19

Chlamydia trachomatis genital infection is the most common sexually transmitted bacterial disease, causing a significant burden to females due to reproductive dysfunction. Intensive screening and antibiotic treatment are unable to completely prevent female reproductive dysfunction, thus, efforts have become focused on developing a vaccine. A major impediment is identifying a safe and effective adjuvant which induces cluster of differentiation 4 (CD4) cells with attributes capable of halting genital infection and inflammation. Previously, we described a natural nanocapsule called the vault which was engineered to contain major outer membrane protein (MOMP) and was an effective vaccine which significantly reduced early infection and favored development of a cellular immune response in a mouse model. In the current study, we used another chlamydial antigen, a polymorphic membrane protein G-1 (PmpG) peptide, to track antigen-specific cells and evaluate, in depth, the vault vaccine for its protective capacity in the absence of an added adjuvant. We found PmpG-vault immunized mice significantly reduced the genital bacterial burden and histopathologic parameters of inflammation following a C. muridarum challenge. Immunization boosted antigen-specific CD4 cells with a multiple cytokine secretion pattern and reduced the number of inflammatory cells in the genital tract making the vault vaccine platform safe and effective for chlamydial genital infection. We conclude that vaccination with a Chlamydia -vault vaccine boosts antigen-specific immunities that are effective at eradicating infection and preventing reproductive tract inflammation.

A Protective Vaccine against Chlamydia Genital Infection Using Vault Nanoparticles without an Added Adjuvant

Directory of Open Access Journals (Sweden)

Janina Jiang

2017-01-01

Full Text Available Chlamydia trachomatis genital infection is the most common sexually transmitted bacterial disease, causing a significant burden to females due to reproductive dysfunction. Intensive screening and antibiotic treatment are unable to completely prevent female reproductive dysfunction, thus, efforts have become focused on developing a vaccine. A major impediment is identifying a safe and effective adjuvant which induces cluster of differentiation 4 (CD4 cells with attributes capable of halting genital infection and inflammation. Previously, we described a natural nanocapsule called the vault which was engineered to contain major outer membrane protein (MOMP and was an effective vaccine which significantly reduced early infection and favored development of a cellular immune response in a mouse model. In the current study, we used another chlamydial antigen, a polymorphic membrane protein G-1 (PmpG peptide, to track antigen-specific cells and evaluate, in depth, the vault vaccine for its protective capacity in the absence of an added adjuvant. We found PmpG-vault immunized mice significantly reduced the genital bacterial burden and histopathologic parameters of inflammation following a C. muridarum challenge. Immunization boosted antigen-specific CD4 cells with a multiple cytokine secretion pattern and reduced the number of inflammatory cells in the genital tract making the vault vaccine platform safe and effective for chlamydial genital infection. We conclude that vaccination with a Chlamydia-vault vaccine boosts antigen-specific immunities that are effective at eradicating infection and preventing reproductive tract inflammation.

Side loading vault system and method for the disposal of radioactive waste

International Nuclear Information System (INIS)

Meess, D.C.; Jones, B.J.; Mello, R.M.; Weiss, T.G. Jr.; Wright, J.B.

1990-01-01

This patent describes a method for the disposal of hazardous radioactive waste. It comprises: constructing a floor slab in the earth; constructing an elongated wall assembly over the floor slab having sidewalls and a front wall and a back wall at either end the side walls being longer than the front and back walls; providing an accessway in the front wall; constructing a ceiling slab over the wall assembly that is supported at least in part by the wall assembly to form a vault cell; inspecting the vault cell for structural defects, introducing hazardous radioactive waste through the accessway in the front wall and loading the cell with the waste from the back wall to the front wall in rows, each of which is substantially parallel to the back wall to minimize radiation exposure to workers loading the cell, and closing the accessway of the vault cell by constructing a removable wall structure within the accessway

The "Akopian" vault performed by elite male gymnasts: Which biomechanical variables are related to a judge's score?

Directory of Open Access Journals (Sweden)

Roman Farana

2015-03-01

Full Text Available Background: A vaulting performance takes a short time and it is influenced by and affects the quantity of mechanical variables. The significant relationships between the vaulting score and specific aspects of the gymnast's vault should conduct coaches to monitor these variables as a part of training or routine testing. Objective: The aim of the current study was to determine the biomechanical variables that are related to a successful performance of the Akopian vaults performed by top level male gymnasts during the World Cup competition. Methods: Fifteen top-level male gymnasts participated in this study. For the 3D analysis, two digital camcorders with a frame rate of 50 Hz were used. The data were digitized by the Simi motion software. The Hay and Reid method was used to identify the biomechanical variables that determine the linear and angular motions of the handspring and front somersault vaults. A correlation analysis was used to establish the relationship between the biomechanical variables and the judges' scores. The level of statistical significance was determined at the value of p < .05. Results: In the Akopian vaults, in five out of 24 variables arising from the deterministic model showed a significant relationship to the score. A significant correlation was found in the maximum height of the body center of mass in the second flight phase, in the height of the body center of mass at the mat touchdown, in the change of the vertical velocity during the take-off from the vaulting table, and in the duration of the second flight phase. Conclusions: The results of the study suggest that a successful execution of Akopian vaults and the achievement of a higher score required: to maximize the change in vertical velocity in the table contact phase and maximize vertical velocity in the table take-off phase; to maximize the amplitude of the second flight phase, which is determined by the duration of the second flight phase, by the maximum

Introduction of microbial nutrients in a nuclear fuel waste disposal vault as a result of excavation and operation activities

Energy Technology Data Exchange (ETDEWEB)

Stroes-Gascoyne, S; Gascoyne, M; Onagi, D; Thomas, D A; Hamon, C J; Watson, R; Porth, R J

1996-08-01

A nuclear fuel waste disposal vault would not likely be a sterile environment. Bacterial activity would be expected in those areas of the vault conducive to bacterial life, i.e., where effects of heat, moisture content, radiation and compaction would not prevent or severely restrict bacterial life and where suitable and sufficient nutrients would be present. An inventory of bacterial nutrients that would be emplaced `intentionally` with vault materials (fuel waste, waste containers, buffer and backfill materials) has been made previously. This report assesses bacterial nutrients that would be added `inadvertently` to a vault in the form of residues of materials used to excavate and operate a vault. Measurements of blasting material residues in the various water supplies, excavated broken rock (muck) and in cores drilled in old and new tunnel walls were made at AECL`s Underground Research Laboratory. Results show that the largest potential nutrient addition (both carbon and nitrogen) to a vault would result from using untreated excavated broken rock as part of the backfill. (author). 16 refs., 4 tabs., 10 figs.

Introduction of microbial nutrients in a nuclear fuel waste disposal vault as a result of excavation and operation activities

International Nuclear Information System (INIS)

Stroes-Gascoyne, S.; Gascoyne, M.; Onagi, D.; Thomas, D.A.; Hamon, C.J.; Watson, R.; Porth, R.J.

1996-08-01

A nuclear fuel waste disposal vault would not likely be a sterile environment. Bacterial activity would be expected in those areas of the vault conducive to bacterial life, i.e., where effects of heat, moisture content, radiation and compaction would not prevent or severely restrict bacterial life and where suitable and sufficient nutrients would be present. An inventory of bacterial nutrients that would be emplaced 'intentionally' with vault materials (fuel waste, waste containers, buffer and backfill materials) has been made previously. This report assesses bacterial nutrients that would be added 'inadvertently' to a vault in the form of residues of materials used to excavate and operate a vault. Measurements of blasting material residues in the various water supplies, excavated broken rock (muck) and in cores drilled in old and new tunnel walls were made at AECL's Underground Research Laboratory. Results show that the largest potential nutrient addition (both carbon and nitrogen) to a vault would result from using untreated excavated broken rock as part of the backfill. (author). 16 refs., 4 tabs., 10 figs

All-magnetic extraction for cyclotron beam reacceleration

Science.gov (United States)

Hudson, E.D.; Mallory, M.L.

1975-07-22

An isochronous cyclotron can be modified to provide an initial electron stripping stage, a complete acceleration of the stripped ions through the cyclotron to a first energy state, means for returning the ions to an intermediate cyclotron orbit through a second stripping stage, further acceleration of the now higher energy stripped ions through the cyclotron to their final energy, and final extraction of the ions from the cyclotron. (auth)

Disruption of the murine major vault protein (MVP/LRP) gene does not induce hypersensitivity to cytostatics

NARCIS (Netherlands)

M.H. Mossink (Marieke); A. van Zon (Arend); A.A. Fränzel-Luiten (Erna); M. Schoester (Martijn); V.A. Kickhoefer; G.L. Scheffer (George); R.J. Scheper (Rik); P. Sonneveld (Pieter); E.A.C. Wiemer (Erik)

2002-01-01

textabstractVaults are ribonucleoprotein particles with a distinct structure and a high degree of conservation between species. Although no function has been assigned to the complex yet, there is some evidence for a role of vaults in multidrug resistance. To confirm a direct

The 200 MeV cyclotron facility

International Nuclear Information System (INIS)

1987-01-01

Beams of protons with several different energies have now been successfully transported between the injector cyclotron SPC1 and the SSC. Some small modifications to the placement of steering magnets and diagnostic equipment have been made in the light of our operational experience, which should improve the ease of tuning this beamline. Proton beams up to 200 MeV in energy have been transported to the experimental areas, where experiments in nuclear physics have been successful conducted. Three of the experimental beamlines are now in operation. Beams of 66 MeV protons have also been transported to targets in the isotope production vault, without difficulty. Field mapping of the remaining quadrupoles on site has been completed. Installation of and alignment of magnets up to the beam swinger is also complete, although the beam tube itself, plus vacuum and diagnostic equipment must still be tackled. The beam swinger has been designed and detailed in the drawing office, and is now being manufactured locally. The beamline elements for the sepctrometer beamline remain to be purchased. A personal computer has been purchased for controlling the field-mapping equipment for the spectrometer magnets, which are being manufactured in this country. A number of computer programs have been written for conversion of calibrated quadrupole and dipole magnet field data to absolute current values for the control system. Other programs permit diagnostic measurements of beam profiles to be used to calculated the beam emittance, or to set steering magnets so that the beam is correctly aligned

Conceptual design of the RF accelerating cavities for a superconducting cyclotron

International Nuclear Information System (INIS)

Maggiore, M.; Calabretta, L.; Di Giacomo, M.; Rifuggiato, D.; Battaglia, D.; Piazza, L.

2006-01-01

A superconducting cyclotron accelerating ions up to 250 A MeV, for medical applications and radioactive ions production is being studied at Laboratori Nazionali del Sud in Catania. The radio frequency (RF) system, working in the fourth harmonic, is based on four normal conducting radio frequency cavities operating at 93 MHz. This paper describes an unusual multi-stem cavity design, performed with 3D electromagnetic codes. Our aim is to obtain a cavity, completely housed inside the cyclotron, with a voltage distribution ranging from 65 kV in the injection region to a peak value of 120 kV in the extraction region, and having a low power consumption

Hazard evaluation for 244-AR vault facility

International Nuclear Information System (INIS)

BRAUN, D.J.

1999-01-01

This document presents the results of a hazard identification and evaluation performed on the 244-AR Vault Facility to close a USQ (USQ No. TF-98-0785, Potential Inadequacy in Authorization Basis (PIAB): To Evaluate Miscellaneous Facilities Listed in HNF-2503 And Not Addressed In The TWRS Authorization Basis) that was generated as part of an evaluation of inactive TWRS facilities

SIIOS in Alaska - Testing an `In-Vault' Option for a Europa Lander Seismometer.

Science.gov (United States)

Bray, V. J.; Weber, R. C.; DellaGiustina, D. N.; Bailey, H.; Schmerr, N. C.; Pettit, E. C.; Dahl, P.; Albert, D.; Avenson, B.; Byrne, S.; Siegler, M.; Bland, M. T.; Patterson, G. W.; Selznick, S.

2017-12-01

The surface environment of Europa within the radiation-heavy jovian system, poses extreme technical challenges for potential landed missions. The need for radiation shielding and protection from the cold requires instruments to be housed within a thermally insulated and radiation protected `vault'. Unfortunately, this is non-ideal for seismometers as instrument-to-surface coupling is an important factor in the quality of returned data. Delivering a seismic package to an icy world would therefore benefit from the development of a cold-tolerant, radiation-hardened sensor that can survive outside of a protective vault. If such an instrument package were not technologically mature enough, or if lander safety considerations prevent deployment on lander legs, an in-vault location is still a viable option. For such a case, a better understanding of the transmission of seismic signals received through the lander legs is necessary for interpretation of the received signals. The performance, mass, and volume of the `Seismometer to investigate ice and ocean structure' (SIIOS) already meet or exceed flight requirements identified in lander studies for the icy moon Europa. We are testing this flight-candidate in several configurations around and within a lander mock-up, assuming a 1x1 meter vault with extended legs. We compare the received signals from a SIIOS device on the ice with those received by an identical sensor directly above it in the `vault'. We also compare the data from these single-point receivers to that received by two short base-line arrays - A 4-point "in-vault" array and another 4-point array arranged at the ice surface at the base of the lander legs. Our field-testing is performed at Gulkana Glacier, Alaska. The summer melt season provides kilometer-scale regions of coexisting ice, water, and silicate material, thereby providing seismic contrasts analogous to the ice-water layers and possible sub-surface lakes expected at Europa. We demonstrate the

Dispersion, mixing and intentional ignition of hydrogen in the Darlington reactor vault

International Nuclear Information System (INIS)

Lee, J.H.S.; Knystautas, R.

1989-03-01

The present report reviews the Darlington Safety Report (DSR) which has been used as basis for decisions regarding intentional ignition in the Darlington reactor vault. The validity of the assumptions in the DSR regarding mixing of contents is assessed and possible hydrogen release scenarios, specific to the Darlington reactor vault, are examined. The combustion analysis in the DSR vent code calculations are reviewed in the light of existing state of the art information on high speed turbulent flames and transition to detonation. Limitations of the vent code, in this context, are identified and improvements recommended

Experimental modelling of core debris dispersion from the vault under a PWR pressure vessel: Part 1

International Nuclear Information System (INIS)

Macbeth, R.V.; Trenberth, R.

1987-12-01

Modelling experiments have been done on a 1/25 scale model in Perspex of the vault under a PWR pressure vessel. Various liquids have been used to simulate molten core debris assumed to have fallen on to the vault floor from a breach at the bottom of the pressure vessel. High pressure air and helium have been used to simulate the discharge of steam and gas from the breach. The dispersion of liquid via the vault access shafts has been measured. Photographs have been taken of fluid flow patterns and velocity profiles have been obtained. The requirements for further experiments are indicated. (author)

Seismic scoping evaluation of high level liquid waste tank vaults at the Idaho Chemical Processing Plant

International Nuclear Information System (INIS)

Hashimoto, P.S.; Uldrich, E.D.; McGee, W.D.

1991-01-01

A seismic scoping evaluation of buried vaults enclosing high level liquid waste storage tanks at the Idaho Chemical Processing Plant has been performed. The objective of this evaluation was to scope out which of the vaults could be demonstrated to be seismically adequate against the Safe Shutdown Earthquake (SSE). Using approximate analytical methods, earthquake experience data, and engineering judgement, this study determined that one vault configuration would be expected to meet ICPP seismic design criteria, one would not be considered seismically adequate against the SSE, and one could be shown to be seismically adequate against the SSE using nonlinear analysis

Computer design of a compact cyclotron

International Nuclear Information System (INIS)

Bing Wang; Huanfeng Hao; Qinggao Yao; Jinquan Zhang; Mingtao Song; Vorozhtsov, S.B.; Smirnov, V.L.; Hongwei Zhao

2011-01-01

Here we present results of the computer design of the structural elements of a compact cyclotron by the example of HITFiL cyclotron selected as the driving accelerator that is under construction at the Institute of Modern Physics (Lanzhou, China). In the article a complex approach to modeling of the compact cyclotron, including calculation of electromagnetic fields of the structural elements and beam dynamics calculations, is described. The existing design data on the axial injection, magnetic, acceleration and extraction systems of the cyclotron are used as a starting point in the simulation. Some of the upgrades of the cyclotron structural elements were proposed, which led to substantial improvement of the beam quality and transmission

Thickened cranial vault and parasagittal keeling: correlated traits and autapomorphies of Homo erectus?

Science.gov (United States)

Balzeau, Antoine

2013-06-01

Homo erectus sensu lato (s.l.) is a key species in the hominin fossil record for the study of human evolution, being one of the first species discovered and perhaps the most documented, but also because of its long temporal range and having dispersed out of Africa earlier than any other human species. Here I test two proposed autapomorphic traits of H. erectus, namely the increased thickness of the upper cranial vault and parasagittal keeling. The definition of these two anatomical features and their expression and variation among hominids are discussed. The results of this study indicate that the upper vault in Asian H. erectus is not absolutely thicker compared with fossil anatomically modern Homo sapiens, whereas Broken Hill and Petralona have values above the range of variation of H. erectus. Moreover, this anatomical region in Asian H. erectus is not significantly thicker compared with Pan paniscus. In addition, these results demonstrate that cranial vault thickness should not be used to make hypotheses regarding sexual attribution of fossil hominin specimens. I also show that the relation between relief on the external surface of the upper vault, parasagittal keeling and bregmatic eminence, and bone thickness is complex. In this context, the autapomorphic status of the two analysed traits in H. erectus may be rejected. Nevertheless, different patterns in the distribution of bone thickness on the upper vault were identified. Some individual variations are visible, but specificities are observable in samples of different species. The pattern of bone thickness distribution observed in Asian H. erectus, P. paniscus, possibly australopiths, and early Homo or Homo ergaster/erectus appears to be shared by these different species and would be a plesiomorphic trait among hominids. In contrast, two apomorphic states for this feature were identified for Neandertals and H. sapiens. Copyright © 2013 Elsevier Ltd. All rights reserved.

Startup work on Inshas cyclotron

International Nuclear Information System (INIS)

Vorogushin, M.F.; Strokach, A.P.; Shikhov, V.Ya.; Galchuk, A.V.; Soliman, A.N.; El-Abyad, M.; Comsan, M.N.H.; Saleh, Z.A.; Azzam, A.N.

2001-01-01

Startup works on the MGC-20 variable energy cyclotron in the Inshas Nuclear Research Center (Egypt) are described. The cyclotron is intended for acceleration of hydrogen and helium ions in a wide energy range (for protons - from 5 to 20 MeV). Main units of the cyclotron and results of computer experimental acceleration of protons to 18 MeV are described. The prospects of furthers investigations are presented [ru

Operating experience of vault type dry storage and its relevance to future storage needs

International Nuclear Information System (INIS)

Maxwell, E.O.; Deacon, D.

1982-01-01

An outline description of the early passive cooled vault type dry stores for irradiated magnox fuel at the Wylfa Nuclear Power Station together with the valuable operating experience gained over many years. An outline description of the world's first air-cooled vault type dry store (350 Te) and comments on its construction and successful operation. A description of the basic principles that were used in the design of this store and how these principles have been developed for use on vault type storage systems for oxide fuel and vitrified waste. An examination of the basic parameters that the author's consider should be used to measure the adequacy of the many storage options currently being considered around the world is included in order that a better assessment of the various systems may be obtained

Measurements and evaluation of the risks due to external radiation exposures and to intake of activated elements for operational staff engaged in the maintenance of medical cyclotrons.

Science.gov (United States)

Calandrino, R; del Vecchio, A; Parisi, R; Todde, S; De Felice, P; Savi, A; Pepe, A; Mrskova, A

2010-06-01

The aim of this paper is to assess the activation phenomena and to evaluate the risk of external exposure and intake doses for the maintenance staff of two medical cyclotrons. Two self-shielded cyclotrons are currently operating in the facility for the routine production of (11)C and (18)F. Four radiochemistry laboratories are linked to the cyclotrons by means of shielded radioisotope delivery lines. Radiopharmaceuticals are prepared both for the PET Diagnostic Department, where four CT-PET scanners are operating with a mean patient workload of 40 d(-1) and for [(18)F]FDG external distribution, to provide radiopharmaceuticals for other institutions. In spite of the fact that air contamination inside the radiochemistry laboratories during the synthesis represents the largest 'slice of the pie' in the evaluation of annual intake dose, potential contamination due to the activated particulate, generated during cyclotron irradiation by micro-corrosion of targets and other components potentially struck by the proton beam and generated neutrons, should be considered. In this regard, the most plausible long-lived (T(1/2) > 30 d) radioisotopes formed are: (97)Tc, (56)Co, (57)Co, (58)Co, (60)Co, (49)V, (55)Fe, (109)Cd, (65)Zn and (22)Na. The results for the operating personnel survey has revealed only low-level contamination for (65)Zn in one test, together with minor (18)F intake, probably due to the environmental dispersion of the radioisotope during the [(18)F]FDG synthesis.

Choosing the right materials for a dry vault store

International Nuclear Information System (INIS)

Walters, J.

1985-01-01

Britain's National Nuclear Corporation has been treating various materials to see if they would be suitable for the construction of a dry vault store for spent fuel and/or vitrified waste. The factors influencing the choice of materials are considered. (UK)

Overexpression of the human major vault protein in gangliogliomas.

NARCIS (Netherlands)

Aronica, E; Gorter, J.A.; Vliet, van EA; Spliet, WG; Veelen, van CW; Rijen, van PC; Leenstra, S.; Ramkema, MD; Scheffer, G.L.; Scheper, R.J.; Sisodiya, SM; Troost, D.

2003-01-01

PURPOSE: Recent evidence has been obtained that the major vault protein (MVP) may play a role in multidrug resistance (MDR). We investigated the expression and cellular localization of MVP in gangliogliomas (GGs), which are increasingly recognized causes of chronic pharmacoresistant epilepsy.

Overexpression of the human major vault protein in gangliogliomas

NARCIS (Netherlands)

Aronica, Eleonora; Gorter, Jan A.; van Vliet, Erwin A.; Spliet, Wim G. M.; van Veelen, Cees W. M.; van Rijen, Peter C.; Leenstra, Sieger; Ramkema, Marja D.; Scheffer, George L.; Scheper, Rik J.; Sisodiya, Sanjay M.; Troost, Dirk

2003-01-01

Purpose: Recent evidence has been obtained that the major vault protein (MVP) may play a role in multidrug resistance (MDR). We investigated the expression and cellular localization of MVP in gangliogliomas (GGs), which are increasingly recognized causes of chronic pharmacoresistant epilepsy.

Data vaults: a database welcome to scientific file repositories

NARCIS (Netherlands)

Ivanova, M.; Kargın, Y.; Kersten, M.; Manegold, S.; Zhang, Y.; Datcu, M.; Espinoza Molina, D.

2013-01-01

Efficient management and exploration of high-volume scientific file repositories have become pivotal for advancement in science. We propose to demonstrate the Data Vault, an extension of the database system architecture that transparently opens scientific file repositories for efficient in-database

Correlation of Palatal Rugoscopy with Gender, Palatal Vault Height ...

African Journals Online (AJOL)

Allen in 1889[3] discussed their role as an identification method. ... a typical orientation pattern, once formed; only changed in its length due to ... along with palatal vault forms as well as ABO blood groups for racial and individualistic soft.

Expression profiles of vault components MVP, TEP1 and vPARP and their correlation to other multidrug resistance proteins in ovarian cancer.

Science.gov (United States)

Szaflarski, Witold; Sujka-Kordowska, Patrycja; Pula, Bartosz; Jaszczyńska-Nowinka, Karolina; Andrzejewska, Małgorzata; Zawierucha, Piotr; Dziegiel, Piotr; Nowicki, Michał; Ivanov, Pavel; Zabel, Maciej

2013-08-01

Vaults are cytoplasmic ribonucleoprotein particles composed of three proteins (MVP, TEP1, vPARP) and vault‑associated RNAs (vRNAs). Although the cellular functions of vaults remain unclear, vaults are strongly linked to the development of multidrug resistance (MDR), the major obstacle to the efficient treatment of cancers. Available published data suggest that vaults and their components are frequently upregulated in broad variety of multidrug-resistant cancer cell lines and tumors of different histological origin. Here, we provide detailed analysis of vault protein expression in post-surgery ovarian cancer samples from patients that were not exposed to chemotherapy. Our analysis suggests that vault proteins are expressed in the ovaries of healthy individuals but their expression in cancer patients is changed. Specifically, MVP, TEP1 and vPARP mRNA levels are significantly decreased in cancer samples with tendency of lower expression in higher-grade tumors. The pattern of vault protein mRNA expression is strongly correlated with the expression of other MDR-associated proteins such as MDR1, MRP1 and BCRP. Surprisingly, the protein levels of MVP, TEP1 and vPARP are actually increased in the higher‑grade tumors suggesting existence of post-transcriptional regulation of vault component production.

Status report on electron cyclotron resonance ion sources at the Heavy Ion Medical Accelerator in Chiba

CERN Document Server

Kitagawa, A; Sekiguchi, M; Yamada, S; Jincho, K; Okada, T; Yamamoto, M; Hattori, T G; Biri, S; Baskaran, R; Sakata, T; Sawada, K; Uno, K

2000-01-01

The Heavy Ion Medical Accelerator in Chiba at the National Institute of Radiological Sciences (NIRS) is not only dedicated to cancer therapy, it is also utilized with various ion species for basic experiments of biomedical science, physics, chemistry, etc. Two electron cyclotron resonance (ECR) ion sources are installed for production of gaseous ions. One of them, the NIRS-ECR, is a 10 GHz ECR ion source, and is mainly operated to produce C/sup 4+/ ions for daily clinical treatment. This source realizes good reproducibility and reliability and it is easily operated. The other source, the NIRS-HEC, is an 18 GHz ECR ion source that is expected to produce heavier ion species. The output ion currents of the NIRS-ECR and the NIRS-HEC are 430e mu A for C/sup 4+/ and 1.1e mA for Ar/sup 8+/, respectively. (14 refs).

Cyclotron-produced radioisotopes and their clinical use at the Austin PET Centre

International Nuclear Information System (INIS)

Tochon-Danguy, H.J.

1997-01-01

A Centre for Positron Emission Tomography (PET) has been established within the Department of Nuclear Medicine at the Austin and Repatriation Medical Centre in Melbourne. PET is a non-invasive technique based on the use of biologically relevant compounds labelled with short-lived positron-emitting radionuclides such as carbon-11, nitrogen-13, oxygen-15 and fluorine-18. The basic equipment consists of a medical cyclotron (10 MeV proton and 5 MeV deuteron), six lead-shielded hot cells with associated radiochemistry facilities and a whole body PET scanner. During its first five years of operation, the Melbourne PET Centre, has pursued a strong radiolabelling development program, leading to an ambitious clinical program in neurology, oncology and cardiology. This presentation will describe the basic principles of the PET technique and review the cyclotron-produced radioisotopes and radiopharmaceuticals. Radiolabelling development programs and clinical applications are also addressed

General aspects of radiological protection to consider for the licensing a hospital cyclotron

International Nuclear Information System (INIS)

Andrada Contardi, F.A.; Fruttero, N.H.; Bozzo, R.H.; Moschella, E.G.

2010-01-01

The use of PET/PET-CT studies for a variety of diagnoses has increased significantly on a global scale. Modern medical cyclotrons must be placed in or near hospitals on account of the short radioactive half-life of the pharmaceuticals used in such studies. Many countries in Latin America are now licensing cyclotrons and laboratories for the production of radio-pharmaceuticals for the first time, and most are expected to have installations within the near future. This report outlines the general aspects of radiological protection important to consideration during the licensing of these facilities, and includes the following: general operation of the cyclotron and laboratory for the production of radiopharmaceuticals, safety systems (shielding, interlocks, ventilation, manual safety systems, alarms and monitors), and general aspects for licensing an installation (monitoring, accidental and incidental events, activation of components, etc.) and personnel. (authors) [es

A comparison of Coulomb and pseudo-Coulomb friction implementations: Application to the table contact phase of gymnastics vaulting.

Science.gov (United States)

Jackson, M I; Hiley, M J; Yeadon, M R

2011-10-13

In the table contact phase of gymnastics vaulting both dynamic and static friction act. The purpose of this study was to develop a method of simulating Coulomb friction that incorporated both dynamic and static phases and to compare the results with those obtained using a pseudo-Coulomb implementation of friction when applied to the table contact phase of gymnastics vaulting. Kinematic data were obtained from an elite level gymnast performing handspring straight somersault vaults using a Vicon optoelectronic motion capture system. An angle-driven computer model of vaulting that simulated the interaction between a seven segment gymnast and a single segment vaulting table during the table contact phase of the vault was developed. Both dynamic and static friction were incorporated within the model by switching between two implementations of the tangential frictional force. Two vaulting trials were used to determine the model parameters using a genetic algorithm to match simulations to recorded performances. A third independent trial was used to evaluate the model and close agreement was found between the simulation and the recorded performance with an overall difference of 13.5%. The two-state simulation model was found to be capable of replicating performance at take-off and also of replicating key contact phase features such as the normal and tangential motion of the hands. The results of the two-state model were compared to those using a pseudo-Coulomb friction implementation within the simulation model. The two-state model achieved similar overall results to those of the pseudo-Coulomb model but obtained solutions more rapidly. Copyright © 2011 Elsevier Ltd. All rights reserved.

Evaluating the potential for large-scale fracturing at a disposal vault: an example using the underground research laboratory

Energy Technology Data Exchange (ETDEWEB)

Martin, C D; Chandler, N A; Brown, Anton

1994-09-01

The potential for large-scale fracturing (> 10 m{sup 2}) around a nuclear fuel waste disposal vault is investigated in this report. The disposal vault is assumed to be located at a depth of 500 m in the plutonic rocks of the Canadian Shield. The rock mass surrounding the disposal vault is considered to have similar mechanical properties and in situ stress conditions to that found at a depth of 420 m at the Underground Research Laboratory. Theoretical, experimental and field evidence shows that Mode I fractures propagate in a plane perpendicular to {sigma}{sub 3} and only if the tensile stress at the tip of the advancing crack is sufficient to overcome the tensile strength of the rock. Because the stress state at a depth of 500 m or more is compressive, and will very probably stay so during the 10,000 year life of the disposal vault, there does not appear to be any mechanism which could propagate large-scale Mode I fracturing in the rock mass surrounding the vault. In addition because {sigma}{sub 3} is near vertical any Mode I fracture propagation that might occur would be in a horizontal plane. The development of either Mode I or large-scale shear fractures would require a drastic change in the compressive in situ stress state at the depth of the disposal vault. The stresses developed as a result of both thermal and glacial loading do not appear sufficient to cause new fracturing. Glacial loading would reduce the shear stresses in the rock mass and hence improve the stability of the rock mass surrounding the vault. Thus, it is not feasible that large-scale fracturing would occur over the 10,000 year life of a disposal vault in the Canadian Shield, at depths of 500 m or greater, where the compressive stress state is similar to that found at the Underground Research Laboratory. 107 refs., 44 figs.

Evaluating the potential for large-scale fracturing at a disposal vault: an example using the underground research laboratory

International Nuclear Information System (INIS)

Martin, C.D.; Chandler, N.A.; Brown, Anton.

1994-09-01

The potential for large-scale fracturing (> 10 m 2 ) around a nuclear fuel waste disposal vault is investigated in this report. The disposal vault is assumed to be located at a depth of 500 m in the plutonic rocks of the Canadian Shield. The rock mass surrounding the disposal vault is considered to have similar mechanical properties and in situ stress conditions to that found at a depth of 420 m at the Underground Research Laboratory. Theoretical, experimental and field evidence shows that Mode I fractures propagate in a plane perpendicular to σ 3 and only if the tensile stress at the tip of the advancing crack is sufficient to overcome the tensile strength of the rock. Because the stress state at a depth of 500 m or more is compressive, and will very probably stay so during the 10,000 year life of the disposal vault, there does not appear to be any mechanism which could propagate large-scale Mode I fracturing in the rock mass surrounding the vault. In addition because σ 3 is near vertical any Mode I fracture propagation that might occur would be in a horizontal plane. The development of either Mode I or large-scale shear fractures would require a drastic change in the compressive in situ stress state at the depth of the disposal vault. The stresses developed as a result of both thermal and glacial loading do not appear sufficient to cause new fracturing. Glacial loading would reduce the shear stresses in the rock mass and hence improve the stability of the rock mass surrounding the vault. Thus, it is not feasible that large-scale fracturing would occur over the 10,000 year life of a disposal vault in the Canadian Shield, at depths of 500 m or greater, where the compressive stress state is similar to that found at the Underground Research Laboratory. 107 refs., 44 figs

Standardized high current solid targets for cyclotron production of radionuclides

International Nuclear Information System (INIS)

Al-Jammaz, Ibrahim

2000-01-01

The Cyclotron and Radiopharmaceuticals Department (CRP) is an advanced and modern facility that encompasses two essential components: radioisotope research, and radiopharmaceuticals manufacturing. Radiopharmaceuticals manufacturing program is not only quite unique, but also an essential component of King Faisal Specialist Hospital and Research Center (KFSH and RC) in providing quality patient care for the population of the Kingdom. Accurate diagnosis and therapy with medical imaging equipment requires quality radiopharmaceuticals that are available readily and with reliability. The CRP Department provides that quality and reliability. Research activities of the CRP Department are focused on developing new radiotracers with potential usefulness in biomedical research and clinical applications. Research projects consist of: developing cyclotron targetry for radioisotope production; developing synthesis methods for radiolabeling biomolecules; and developing analytical methods for quality control. The CRP Department operates a semi-commercial radiopharmaceuticals manufacturing program that supplies the diagnostic radioactive products to several hospitals in the Kingdom and neighboring countries. These products for clinical applications are produced according to the international standards of Good Manufacturing Practices of quality and efficacy. At the heart of the radioisotope program is a medium energy cyclotron capable of accelerating a number of particles for transformation of non-radioactive atoms into radionuclides that are the primary sources for research and development activities, and for preparing radiopharmaceuticals. In addition to having the only cyclotron facility in the region, KFSH and RC also has the only Positron Emission Tomography Center (PET) in this part of the world. This combination of cyclotron and the ultra modern PET facility translates into advanced and specialized care for the patients at KFSH and RC

Remote tooling for inspection and repair in Pickering NGS-A calandria vault

International Nuclear Information System (INIS)

Hadji-Mirzai, M.; Tokarz, A.; Vandenberg, J.P.

1993-01-01

In recent years it has been necessary to develop capabilities for the inspection and repair of carbon steel components located within calandria vaults at Ontario Hydro's Pickering Nuclear Generating Station 'A'. Concerns about corrosion of piping and some of the structural components have made necessary the development of remote manipulators to inspect and repair carbon steel components within the vaults to ensure continued reliable operation of the units. Remote manipulators for this program have been designed to perform a number of inspection and repair tasks, and several versions have been developed to specialise in detailed inspection techniques and precision tooling module manipulation. (author)

244-AR vault cooling water stream-specific report

International Nuclear Information System (INIS)

1990-08-01

The proposed wastestream designation for the 244-AR Vault cooling water wastestream is that this stream is not a dangerous waste, pursuant to the Washington (State) Administration Code (WAC) 173-303, Dangerous Waste Regulations. A combination of process knowledge and sampling data was used to make this determination. 21 refs., 6 figs., 7 tabs

Present states and views on vault storage systems

International Nuclear Information System (INIS)

Yoshimura, Eiji

2003-01-01

Storage capacity of spent nuclear fuel storage pools in nuclear power station is reaching to a condition near its limit, and under a condition inevitable on delay of the Pu-thermal utilization plan importance on interim storage of the spent nuclear fuels is further rising. In U.S.A., Germany, and so on, a condition incapable of presenting nuclear energy business itself without its intermediate storage is approaching, so in Japan it will also be a key to smoothly promote the nuclear energy business how the interim storage is used and operated. Under such condition, in Japan storage facilities using a system called by 'metal cask' are established at areas of nuclear power stations to begin their operations. As on the system expensive metal containers are used for storage in themselves, it has a demerit of its high cost. On the other hand, on foreign countries, a storing system called by concrete cask, horizontal silo, or vault is occupying its main stream. Here was introduced present states and future views on vault storage system. (G. K)

Evaluation of {sup 18}F radioactive concentration in exhaust at cyclotron facility at Chosun University

Energy Technology Data Exchange (ETDEWEB)

Jeong, Cheol Ki; Jang, Han; Lee, Goung Jin [Dept. of Nuclear Engineering, Chsoun University, Gwangju (Korea, Republic of)

2016-11-15

the recent prevalence of PET examinations in Korea has led to an increase in the number of cyclotrons. the medical isotope 18F produced in most cyclotron facilities currently operating in Korea is emitted into the environment during the production of [{sup 18}F]FdG, a cancerdiagnosis reagent. the amount of [{sup 18}F]FdG synthesized determines the radioactive concentration of {sup 18}F in the exhaust. at some facilities, this amount temporarily exceeds the emission limit. In this study, we evaluated the {sup 18}F radioactivity concentration in the exhaust from the cyclotron facility at chosun university. the {sup 18}F radioactivity concentration was measured using an air sampler and a hPGe semiconductor detector. the measurements showed that the radioactive concentration of {sup 18}F in the exhaust at the cyclotron facility at Chosun university was the highest during [{sup 18}F]FdG synthesis but remained under the legal limit of 2,000 Bq m{sup -3}.

Commercial and PET radioisotope manufacturing with a medical cyclotron

International Nuclear Information System (INIS)

Boothe, T.E.; McLeod, T.F.; Plitnikas, M.; Kinney, D.; Tavano, E.; Feijoo, Y.; Smith, P.; Szelecsenyi, F.

1993-01-01

Mount Sinai has extensive experience in producing radionuclides for commercial sales and for incorporation into radiopharmaceuticals, including PET. Currently, an attempt is being made to supply radiochemicals to radiopharmaceutical manufacturers outside the hospital, to prepare radiopharmaceuticals for in-house use, and to prepare PET radiopharmaceuticals, such as 2-[F-18] FDG, for outside sales. This use for both commercial and PET manufacturing is atypical for a hospital-based cyclotron. To accomplish PET radiopharmaceutical sales, the hospital operates a nuclear pharmacy. A review of operational details for the past several years shows a continuing dependence on commercial sales which is reflected in research and developmental aspects and in staffing. Developmental efforts have centered primarily on radionuclide production, target development, and radiochemical processing optimization. (orig.)

Commercial and PET radioisotope manufacturing with a medical cyclotron

Science.gov (United States)

Boothe, T. E.; McLeod, T. F.; Plitnikas, M.; Kinney, D.; Tavano, E.; Feijoo, Y.; Smith, P.; Szelecsényi, F.

1993-06-01

Mount Sinai has extensive experience in producing radionuclides for commercial sales and for incorporation into radiopharmaceuticals, including PET. Currently, an attempt is being made to supply radiochemicals to radiopharmaceutical manufacturers outside the hospital, to prepare radiopharmaceuticals for in-house use, and to prepare PET radiopharmaceuticals, such as 2-[F-18] FDG, for outside sales. This use for both commercial and PET manufacturing is atypical for a hospital-based cyclotron. To accomplish PET radiopharmaceutical sales, the hospital operates a nuclear pharmacy. A review of operational details for the past several years shows a continuing dependence on commercial sales which is reflected in research and developmental aspects and in staffing. Developmental efforts have centered primarily on radionuclide production, target development, and radiochemical processing optimization.

Development of vault model 'VERMIN' for post closure behaviour of repositories for non-heat generating radioactive wastes

International Nuclear Information System (INIS)

1983-10-01

The computer model VERMIN has been developed to simulate the post closure time dependent behaviour of the vault section of a Land 3 and a Land 2 type repository. Development was carried out within the constraints of the computer code SYVAC. Output from the new model, in terms of radionuclide fluxes versus time, provides the source term for that code. A number of conceptual designs for different geological conditions were produced and used to develop the model. Unlike SYVAC, the boundary of the vault was considered to be at the interface between the damaged rock zone and the undamaged host rock. VERMIN treats the vault as a series of engineered barriers namely: waste matrix, waste package, backfill material liner and the damaged rock zone. For the Land 3 repository, the vault was considered to be fully saturated and consequently corrosion, leading to eventual package failure, will occur. VERMIN allows for package failure and subsequent leaching and then calculates the migration of nuclides from within the vault out to its boundary. One dimensional advection and two dimensional diffusion/dispersion are modelled allowing for retardation due to sorption radionuclide saturation and radionuclide decay. Radioactive decay chains up to eight members can be modelled by VERMIN. (author)

SU-E-T-267: Construction and Evaluation of a Neutron Wall to Shield a 15 MV Linac in a Low-Energy Vault.

Science.gov (United States)

Speiser, M; Hager, F; Foster, R; Solberg, T

2012-06-01

To design and quantify the shielding efficacy of an inner Borated Polyethylene (BPE)wall for a 15 MV linac in a low energy vault. A Varian TrueBeam linac with a maximum photon energy of 15 MV was installed in asmaller, preexisting vault. This vault originally housed a low-energy machine and did not havesufficient maze length recommended for neutron attenuation. Effective dose rate calculationswere performed using the Modified Kersey's Method as detailed in NCRP Report No. 151 andfound to be unacceptably high. An initial survey following the machine installation confirmedthese calculations. Rather than restrict the linac beam energy to 10 MV, BPE was investigatedas a neutron moderating addition. An inner wall and door were planned and constructed using4'×8'×1″ thick 5% BPE sheets. The resulting door and wall had 2″ of BPE; conduits and ductwork were also redesigned and shielded. A survey was conducted following construction of thewall. The vault modification reduced the expected effective dose at the vault door from 36.23to 0.010 mSv/week. As specific guidelines for vault modification are lacking, this project quantitativelydemonstrates the potential use of BPE for vault modification. Such modifications may provide alow-cost shielding solution to allow for the use of high energy modes in smaller treatment vaults. © 2012 American Association of Physicists in Medicine.

A line-of-sight electron cyclotron emission receiver for electron cyclotron resonance heating feedback control of tearing modes

DEFF Research Database (Denmark)

Oosterbeek, J.W.; Bürger, A.; Westerhof, E.

2008-01-01

An electron cyclotron emission (ECE) receiver inside the electron cyclotron resonance heating (ECRH) transmission line has been brought into operation. The ECE is extracted by placing a quartz plate acting as a Fabry-Perot interferometer under an angle inside the electron cyclotron wave (ECW) bea...

Correlation of Palatal Rugoscopy with Gender, Palatal Vault Height ...

African Journals Online (AJOL)

Background: Palatal rugae (PR) are asymmetrical irregular elevations, recorded during maxillary cast fabrication , that can be used for identification purpose if previous comparative sources are available. Aim: This study investigated uniqueness of PR patterns in relation to gender, palatal vault forms, and ABO blood groups ...

Method and apparatus for ion cyclotron spectrometry

Science.gov (United States)

Dahl, David A [Idaho Falls, ID; Scott, Jill R [Idaho Falls, ID; McJunkin, Timothy R [Idaho Falls, ID

2010-08-17

An ion cyclotron spectrometer may include a vacuum chamber that extends at least along a z-axis and means for producing a magnetic field within the vacuum chamber so that a magnetic field vector is generally parallel to the z-axis. The ion cyclotron spectrometer may also include means for producing a trapping electric field within the vacuum chamber that includes at least a first section that induces a first magnetron effect that increases a cyclotron frequency of an ion and at least a second section that induces a second magnetron effect that decreases the cyclotron frequency of an ion. The cyclotron frequency changes induced by the first and second magnetron effects substantially cancel one another so that an ion traversing the at least first and second sections will experience no net change in cyclotron frequency.

Commercial compact cyclotrons in the 90's

International Nuclear Information System (INIS)

Milton, B.F.

1995-09-01

Cyclotrons continue to be efficient accelerators for radio-isotope production. In recent years, developments in the accelerator technology have greatly increased the practical beam current in these machines while also improving the overall system reliability. These developments combined with the development of new isotopes for medicine and industry, and a retiring of older machines indicate a strong future for commercial cyclotrons. In this paper we will survey recent developments in the areas of cyclotron technology, as they relate to the new generation of commercial cyclotrons. Design criteria for the different types of commercial cyclotrons will be presented, with reference to those demands that differ from those in a research oriented cyclotron project. We will also discuss the possibility of systems designed for higher energies and capable of extracted beam currents of up to 2.0 mA. (author)

Commercial compact cyclotrons in the 90's

International Nuclear Information System (INIS)

Milton, B.F.

1995-09-01

Cyclotrons continue to be efficient accelerators for radio-isotope production. In recent years, developments in the accelerator technology have greatly increased the practical beam current in these machines while also improving the overall system reliability. These developments combined with the development of new isotopes for medicine and industry, and a retiring of older machines indicate a strong future for commercial cyclotrons. In this paper the authors will survey recent developments in the areas of cyclotron technology, as they relate to the new generation of commercial cyclotrons. Design criteria for the different types of commercial cyclotrons will be presented, with reference to those demands that differ from those in a research oriented cyclotron project. The authors also discuss the possibility of systems designed for higher energies and capable of extracted beam currents of up to 2.0 mA

Overview of the future upgrade of the INFN-LNS superconducting cyclotron

Science.gov (United States)

Calabretta, Luciano; Calanna, Alessandra; Cuttone, Giacomo; D'Agostino, Grazia; Rifuggiato, Danilo; Domenico Russo, Antonio

2017-06-01

The LNS Superconducting Cyclotron, named “Ciclotrone Superconduttore” (CS), has been in operation for more than 20 years. A wide range of ion species from hydrogen to lead, with energy in the range 10 to 80 AMeV, have been delivered to users. The maximum beam power is limited to 100 W due to the beam dissipation on the electrostatic deflectors. To fulfil the demand of users aiming at studying rare processes in nuclear physics, an upgrade of the cyclotron is necessarily intended to increase the intensity of ion beams with mass lower than 40 a.m.u. up to a power 10 kW. This will be achieved by means of extraction by stripping. This solution needs to replace the cryostat including the superconducting coils. The present capability of the cyclotron will be maintained, i.e. all the ion species allowed by the operating diagram will be available, being extracted by electrostatic extraction. In addition to the high power beams for nuclear physics, it will be possible to produce medical radioisotopes like 211At using an internal target.

244-AR Vault Interim Stabilization Project Plan

International Nuclear Information System (INIS)

LANEY, T.

2000-01-01

The 244-AR Vault Facility, constructed between 1966 and 1968, was designed to provide lag storage and treatment for the Plutonium-Uranium Extraction Facility (PUREX) tank farm sludges. Tank farm personnel transferred the waste from the 244-AR Vault Facility to B Plant for recovery of cesium and strontium. B Plant personnel then transferred the treatment residuals back to the tank farms for storage of the sludge and liquids. The last process operations, which transferred waste supporting the cesium/strontium recovery mission, occurred in April 1978. After the final transfer in 1978, the 244-AR facility underwent a cleanout. However, 2,271 L (600 gal) of sludge were left in Tank 004AR from an earlier transfer from Tank 241-AX-104. When the cleanout was completed, the facility was placed in a standby status. The sludge had been transferred to Tank 004AR to support Pacific Northwest National Laboratory [PNNL] vitrification work. Documentation of waste transfers suggests that a portion of the sludge may have been moved from Tank 004AR to Tank 002AR in preparation for transfer back to the AX Tank Farm; however, quantities of the sludge that were moved to Tank 002AR from that transfer must be estimated

Ion-cyclotron-resonance- and Fourier-transform-ion-cyclotron-resonance spectroscopy: technology and application

International Nuclear Information System (INIS)

Luederwald, I.

1977-01-01

Instrumentation and technology of Ion-Cyclotron-Resonance and Fourier-Transform-Ion-Cyclotron-Resonance Spectroscopy are described. The method can be applied to studies of ion/molecule reactions in gas phase, to obtain thermodynamic data as gas phase acidity or basicity, proton and electron affinity, and to establish reaction mechanisms and ion structures. (orig.) [de

Cyclotron-produced radioisotopes and their clinical use at the Austin PET Centre

Energy Technology Data Exchange (ETDEWEB)

Tochon-Danguy, H.J. [Centre for PET, Melbourne, VIC (Australia). Austin and Repatriation Medical Centre

1997-12-31

A Centre for Positron Emission Tomography (PET) has been established within the Department of Nuclear Medicine at the Austin and Repatriation Medical Centre in Melbourne. PET is a non-invasive technique based on the use of biologically relevant compounds labelled with short-lived positron-emitting radionuclides such as carbon-11, nitrogen-13, oxygen-15 and fluorine-18. The basic equipment consists of a medical cyclotron (10 MeV proton and 5 MeV deuteron), six lead-shielded hot cells with associated radiochemistry facilities and a whole body PET scanner. During its first five years of operation, the Melbourne PET Centre, has pursued a strong radiolabelling development program, leading to an ambitious clinical program in neurology, oncology and cardiology. This presentation will describe the basic principles of the PET technique and review the cyclotron-produced radioisotopes and radiopharmaceuticals. Radiolabelling development programs and clinical applications are also addressed. 30 refs., 1 tab., 1 fig.

A new method for generating an invariant iris private key based on the fuzzy vault system.

Science.gov (United States)

Lee, Youn Joo; Park, Kang Ryoung; Lee, Sung Joo; Bae, Kwanghyuk; Kim, Jaihie

2008-10-01

Cryptographic systems have been widely used in many information security applications. One main challenge that these systems have faced has been how to protect private keys from attackers. Recently, biometric cryptosystems have been introduced as a reliable way of concealing private keys by using biometric data. A fuzzy vault refers to a biometric cryptosystem that can be used to effectively protect private keys and to release them only when legitimate users enter their biometric data. In biometric systems, a critical problem is storing biometric templates in a database. However, fuzzy vault systems do not need to directly store these templates since they are combined with private keys by using cryptography. Previous fuzzy vault systems were designed by using fingerprint, face, and so on. However, there has been no attempt to implement a fuzzy vault system that used an iris. In biometric applications, it is widely known that an iris can discriminate between persons better than other biometric modalities. In this paper, we propose a reliable fuzzy vault system based on local iris features. We extracted multiple iris features from multiple local regions in a given iris image, and the exact values of the unordered set were then produced using the clustering method. To align the iris templates with the new input iris data, a shift-matching technique was applied. Experimental results showed that 128-bit private keys were securely and robustly generated by using any given iris data without requiring prealignment.

Homology of the cranial vault in birds: new insights based on embryonic fate-mapping and character analysis

Science.gov (United States)

Maddin, Hillary C.; Piekarski, Nadine; Sefton, Elizabeth M.; Hanken, James

2016-08-01

Bones of the cranial vault appear to be highly conserved among tetrapod vertebrates. Moreover, bones identified with the same name are assumed to be evolutionarily homologous. However, recent developmental studies reveal a key difference in the embryonic origin of cranial vault bones between representatives of two amniote lineages, mammals and birds, thereby challenging this view. In the mouse, the frontal is derived from cranial neural crest (CNC) but the parietal is derived from mesoderm, placing the CNC-mesoderm boundary at the suture between these bones. In the chicken, this boundary is located within the frontal. This difference and related data have led several recent authors to suggest that bones of the avian cranial vault are misidentified and should be renamed. To elucidate this apparent conflict, we fate-mapped CNC and mesoderm in axolotl to reveal the contributions of these two embryonic cell populations to the cranial vault in a urodele amphibian. The CNC-mesoderm boundary in axolotl is located between the frontal and parietal bones, as in the mouse but unlike the chicken. If, however, the avian frontal is regarded instead as a fused frontal and parietal (i.e. frontoparietal) and the parietal as a postparietal, then the cranial vault of birds becomes developmentally and topologically congruent with those of urodeles and mammals. This alternative hypothesis of cranial vault homology is also phylogenetically consistent with data from the tetrapod fossil record, where frontal, parietal and postparietal bones are present in stem lineages of all extant taxa, including birds. It further implies that a postparietal may be present in most non-avian archosaurs, but fused to the parietal or supraoccipital as in many extant mammals.

High power targets for cyclotron production of 99mTc‡

OpenAIRE

Zeisler, S. K.; Hanemaayer, V.; Buckley, K. R.; Hook, B. K.; MeDiarmid, S.; Klug, J.; Corsaut, J.; Kovacs, M.; Cockburn, N.; Exonomou, C.; Harper, R.; Valliant, J. F.; Ruth, T. J.; Schaffer, P.

2015-01-01

Introduction Technetium-99m, supplied in the form of 99Mo/99mTc generators, is the most widely used radioisotope for nuclear medical imaging. The parent isotope 99Mo is currently produced in nuclear reactors. Recent disruptions in the 99Mo supply chain [1] prompted the development of methods for the direct accelerator-based production of 99mTc. Our approach involves the 100Mo(p,2n)99mTc reaction on isotopically enriched molybdenum using small medical cyclotrons (Ep ≤ 20 MeV), which is ...

20 years Rossendorf cyclotron

International Nuclear Information System (INIS)

1978-08-01

On the occasion of the 20th anniversary of initiating of the Rossendorf cyclotron accounts are given of most important works and results in the field of accelerator engineering and utilization of this machine. The reports show the trend of development and actual spectrum of application. The enclosed literature lists give a survey of technical and experimental works at cyclotron. (author)

In-house cyclotron production of high-purity Tc-99m and Tc-99m radiopharmaceuticals.

Science.gov (United States)

Martini, Petra; Boschi, Alessandra; Cicoria, Gianfranco; Zagni, Federico; Corazza, Andrea; Uccelli, Licia; Pasquali, Micòl; Pupillo, Gaia; Marengo, Mario; Loriggiola, Massimo; Skliarova, Hanna; Mou, Liliana; Cisternino, Sara; Carturan, Sara; Melendez-Alafort, Laura; Uzunov, Nikolay M; Bello, Michele; Alvarez, Carlos Rossi; Esposito, Juan; Duatti, Adriano

2018-05-30

In the last years, the technology for producing the important medical radionuclide technetium-99m by cyclotrons has become sufficiently mature to justify its introduction as an alternative source of the starting precursor [ 99m Tc][TcO 4 ] - ubiquitously employed for the production of 99m Tc-radiopharmaceuticals in hospitals. These technologies make use almost exclusively of the nuclear reaction 100 Mo(p,2n) 99m Tc that allows direct production of Tc-99m. In this study, it is conjectured that this alternative production route will not replace the current supply chain based on the distribution of 99 Mo/ 99m Tc generators, but could become a convenient emergency source of Tc-99m only for in-house hospitals equipped with a conventional, low-energy, medical cyclotron. On this ground, an outline of the essential steps that should be implemented for setting up a hospital radiopharmacy aimed at the occasional production of Tc-99m by a small cyclotron is discussed. These include (1) target production, (2) irradiation conditions, (3) separation/purification procedures, (4) terminal sterilization, (5) quality control, and (6) Mo-100 recovery. To address these issues, a comprehensive technology for cyclotron-production of Tc-99m, developed at the Legnaro National Laboratories of the Italian National Institute of Nuclear Physics (LNL-INFN), will be used as a reference example. Copyright © 2018 Elsevier Ltd. All rights reserved.

Data Vaults: a Database Welcome to Scientific File Repositories

NARCIS (Netherlands)

M.G. Ivanova (Milena); Y. Kargin (Yagiz); M.L. Kersten (Martin); S. Manegold (Stefan); Y. Zhang (Ying); M. Datcu (Mihai); D. Espinoza Molina

2013-01-01

textabstractEfficient management and exploration of high-volume scientific file repositories have become pivotal for advancement in science. We propose to demonstrate the Data Vault, an extension of the database system architecture that transparently opens scientific file repositories for efficient

C235-V3 cyclotron for a proton therapy center to be installed in the hospital complex of radiation medicine (Dimitrovgrad)

Science.gov (United States)

Galkin, R. V.; Gurskii, S. V.; Jongen, Y.; Karamysheva, G. A.; Kazarinov, M. Yu.; Korovkin, S. A.; Kostromin, S. A.; Calderan, J.-M.; Cahay, P.; Mokrenko, S. P.; Morozov, N. A.; Nkongolo, H.; Ol'shevskii, A. G.; Paradis, Y.; Petrov, D. S.; Romanov, V. M.; Samsonov, E. V.; Syresin, E. M.; Shakun, A. N.; Shakun, N. G.; Shirkov, G. D.; Shirkov, S. G.

2014-06-01

Proton therapy is an effective method of treating oncologic diseases. In Russia, construction of several centers for proton and ion therapy is slated for the years to come. A proton therapy center in Dimitrovgrad will be the first. The Joint Institute for Nuclear Research (Russia) in collaboration with Ion Beam Application (IBA) (Belgium) has designed an C235-V3 medical proton cyclotron for this center. It outperforms previous versions of commercial IBA cyclotrons, which have already been installed in 11 oncologic hospital centers in different countries. Experimental and calculation data for the beam dynamics in the C235-V3 medical cyclotron are presented. Reasons for beam losses during acceleration are considered, the influence of the magnetic field radial component in the midplane of the accelerator and main resonances is studied, and a beam extraction system is designed. In 2011-2012 in Dubna, the cyclotron was mounted, its magnetic field was properly configured, acceleration conditions were optimized, and beam extraction tests were carried out after which it was supplied to Dimitrovgrad. In the C235-V3 cyclotron, an acceleration efficiency of 72% and an extraction efficiency of 62% have been achieved without diaphragming to form a vertical profile of the beam.

Numerical and experimental analysis of an in-scale masonry cross-vault prototype up to failure

Energy Technology Data Exchange (ETDEWEB)

Rossi, Michela; Calderini, Chiara; Lagomarsino, Sergio [Department of Civil, Chemical and Environmental Engineering, University of Genoa, Via Montallegro 1, Genoa (Italy); Milani, Gabriele [Department of Architecture, Built Environment and Construction Engineering, Milan Polytechnic University, Piazza Leonardo da Vinci 32, Milan (Italy)

2015-12-31

A heterogeneous full 3D non-linear FE approach is validated against experimental results obtained on an in-scale masonry cross vault assembled with dry joints, and subjected to various loading conditions consisting on imposed displacement combinations to the abutments. The FE model relies into a discretization of the blocks by means of few rigid-infinitely resistant parallelepiped elements interacting by means of planar four-noded interfaces, where all the deformation (elastic and inelastic) occurs. The investigated response mechanisms of vault are the shear in-plane distortion and the longitudinal opening and closing mechanism at the abutments. After the validation of the approach on the experimentally tested cross-vault, a sensitivity analysis is conducted on the same geometry, but in real scale, varying mortar joints mechanical properties, in order to furnish useful hints for safety assessment, especially in presence of seismic action.

Application of superconductivity in cyclotron construction

International Nuclear Information System (INIS)

Blosser, H.G.

1982-01-01

This paper reviews major concepts and design features of the new class of cyclotrons which use superconducting coils to provide main magnet excitation. The discussion begins with a brief historical review tracing the evolution of these ''superconducting'' cyclotrons and the impact of this application of superconductivity in pushing back traditional cyclotron construction limits. This is followed by a review of the principal phenomena which come into play to set new limits on the operating regime, and the nature of these limits, some of which arise from orbit properties and some of which result from construction intricacies in the coil and in the rf system. Conclusions anticipate a future widely encompassing role in the application of superconductivity to cyclotron

Sex determination by three-dimensional geometric morphometrics of the vault and midsagittal curve of the neurocranium in a modern Greek population sample.

Science.gov (United States)

Chovalopoulou, Maria-Eleni; Valakos, Efstratios D; Manolis, Sotiris K

2016-06-01

The aim of this study is to assess sexual dimorphism of adult crania in the vault and midsagittal curve of the vault using three-dimensional geometric morphometric methods. The study sample consisted of 176 crania of known sex (94 males, 82 females) belonging to individuals who lived during the 20th century in Greece. The three-dimensional co-ordinates of 31 ecto-cranial landmarks and 30 semi-landmarks were digitized using a MicroScribe 3DX contact digitizer. Generalized Procrustes analysis (GPA) was used to obtain size and shape variables for statistical analysis. Shape, size and form analyses were carried out by logistic regression and three discriminant function analyses. Results indicate that there are shape differences between sexes. Females in the region of the parietal bones are narrower and the axis forming the frontal and occipital bones is more elongated; the frontal bone is more vertical. Sex-specific shape differences give better classification results in the vault (79%) compared with the midsagittal curve of the neurocranium (68.8%). Size alone yielded better results for cranial vault (82%), while for the midsagittal curve of the vault the result is poorer (68.1%). As anticipated, the classification accuracy improves when both size and shape are combined (89.2% for vault, and 79.4% for midsagittal curve of the vault). These latter findings imply that, in contrast to the midsagittal curve of the neurocranium, the shape of the cranial vault can be used as an indicator of sex in the modern Greek population. Copyright © 2016. Published by Elsevier GmbH.

Vault-Scale Modelling of pH Buffering Capacity in Crushed Granite Backfills

International Nuclear Information System (INIS)

Benbow, Steven; Savage, David; Robinson, Peter; Watson, Sarah

2004-04-01

consist of grains of quartz of uniform size of either 4 or 32 mm diameter. The cement pore fluid diffusing from the waste package was assumed to be pure water saturated with portlandite [Ca(OH) 2 ] at 25 deg C. The pore fluid saturating the backfill was assumed to be pure water equilibrated with quartz at 25 deg C. A number of different simulations were carried out for both 4 and 32 mm diameter gravel backfill grains: 1. A 2D horizontal slice through the vault length with a transmissive feature in the host rock parallel to the vault length, but positioned roughly two vault widths from the vault. 2. As (1) above, but considering a 2D vertical slice through the vault. 3. A 2D horizontal slice through the vault width with a transmissive feature in the host rock normal to the vault length. 4. A 2D horizontal slice through the vault length with a transmissive feature in the host rock intersecting the vault at 45 deg to the vault. An additional simulation was also carried out for the geometry considered in model variant (4) above where reaction of quartz was excluded so that only the reaction of Ca(OH) 2 -saturated fluid with ambient groundwater was simulated. The results of the model variants incorporating reaction of quartz were broadly similar, with few differences apparent for the different orientations of the transmissive feature in the host rock. Most simulations showed that the gravel backfill was capable of maintaining pH 4 moles after 10,000 years in a representative 1 m thick slice through the backfill) were dissolved in the gravel adjacent to the waste package to achieve pH buffering. All of the dissolved quartz was converted to CSH solids (tobermorite and gyrolite). Reactions in simulations with the 4 mm diameter backfill grains were slightly faster, but the results were otherwise identical to those for the 32 mm diameter grains. The model variant with no chemical reaction of the backfill particles was considerably different from the other simulations with pH > 11

Creep in the sparsely fractured rock between a disposal vault and a zone of highly fractured rock

International Nuclear Information System (INIS)

Wilkins, B.J.S.; Rigby, G.L.

1993-08-01

AECL Research is responsible for investigating the feasibility and safety of the disposal of Canada's nuclear fuel waste deep in the plutonic rock of the Canadian Shield. The excavation of the disposal vault, the installation of sealing systems and the heat generated by the fuel waste will all perturb the in situ stress state of the rock mass. This computer codes HOTROK, MCROC and MCDIRC are used to analyze the influence of these stress perturbations on the mechanical behaviour of the rock mass. Time-dependent microcracking of the rock mass will lead to creep around openings in the vault. The analysis specifically estimates the resulting creep strain in the sparsely fractured rock between the edge of the disposal vault and a postulated zone of highly fractured rock. The estimates are extremely conservative. The conclusion reached is that the rock mass more than 3 m beyond the edge of the vault will experience < 0.001 creep strain 100 000 years after the fuel waste is emplaced. (author). 10 refs., 4 tabs., 4 figs

Feasibility Study for a Two-Energy Compact Medical Cyclotron Controlled by Two Pairs of Main Coils

International Nuclear Information System (INIS)

Blum, D.; Breckow, J.; Zink, K.

2013-01-01

At Paul Scherrer Institute, Villigen, Switzerland, protons are accelerated for the proton therapy by a 250 MeV isochronous cyclotron. As for radiotherapy less energy is required (about 70 MeV) a carbon degrader reduces the extracted beam energy. This involves the increase of emittance, decrease of transmission, more activated components and a higher dose for the staff. By extracting a lower energy beam from the cyclotron, less degrade would be necessary and the above mentioned side-effects could be minimized. A possible solution could be to extract two energies from the cyclotron, 250 MeV for very deep located tumours and 230-235 MeV for others. A technically easy and affordable solution for this problem might be a two-energy cyclotron controlled by just two pairs of main coils. The feasibility of this solution has been analysed in this study. The compounded magnetic flux density B is the sum of the coil's and the iron's flux density. The amount caused by a coil is mainly responsible for the shape of the compounded flux density. Therefore a split of the coil pair was simulated to obtain more possibilities in the adjustment of a lower-energy beam to its ideal isochronous shape. The result is a simulated isochronous 240 MeV beam which was found with an tangential split of the coil pair, their repositioning and the increasing of current in the first coil pair and decreasing in the other one. The tangential split seemed to reduce the problem of the irons linear share of B. This feasibility study is seen as a first step before using 3D-capable software which considers a higher spatial resolution and the influence of temperature.(author)

Safety assessment of a vault-based disposal facility using the ISAM methodology

International Nuclear Information System (INIS)

Kelly, E.; Kim, C.-L.; Lietava, P.; Little, R.; Simon, I.

2002-01-01

As part of the IAEA's Co-ordinated Research Project (CRP) on Improving Long-term of Safety Assessment Methodologies for Near Surface Waste Disposal Facilities (ISAM), three example cases were developed. The aim was to testing the ISAM safety assessment methodology using as realistic as possible data. One of the Test Cases, the Vault Test Case (VTC), related to the disposal of low level radioactive waste (LLW) to a hypothetical facility comprising a set of above surface vaults. This paper uses the various steps of the ISAM safety assessment methodology to describe the work undertaken by ISAM participants in developing the VTC and provides some general conclusions that can be drawn from the findings of their work. (author)

Development of a New Cryptographic Construct Using Palmprint-Based Fuzzy Vault

Directory of Open Access Journals (Sweden)

Amioy Kumar

2009-01-01

Full Text Available The combination of cryptology and biometrics has emerged as promising component of information security. Despite the current popularity of palmprint biometric, there has not been any attempt to investigate its usage for the fuzzy vault. This paper therefore investigates the possible usage of palmprint in fuzzy vault to develop a user friendly and reliable crypto system. We suggest the use of both symmetric and asymmetric approach for the encryption. The ciphertext of any document is generated by symmetric cryptosystem; the symmetric key is then encrypted by asymmetric approach. Further, Reed and Solomon codes are used on the generated asymmetric key to provide some error tolerance while decryption. The experimental results from the proposed approach on the palmprint images suggest its possible usage in an automated palmprint-based key generation system.

SHAPE AND CONSTRUCTION OF BRICK VAULTS. CRITERIA, METHODS AND TOOLS FOR A POSSIBLE CATALOGUE

Directory of Open Access Journals (Sweden)

R. Brumana

2017-05-01

Full Text Available The use of cloister vaults in the construction of noble buildings, as covering elements for square or rectangular rooms, is widespread and well-known. The geometric continuity at the intrados makes generally possible the execution all over the span of frescoes, stucco and decorations. The construction of brick vaults, from the late Middle Age, was sped up by limiting the centering to the wooden planks arches that were instrumental in the profile determination. Nowadays, the availability of several procedures, phases and tools for carrying out a survey allows to draw reliable assumptions about the construction methods and the execution time. It is mandatory to determine the properties of the binders, the shape and dimensions of the bricks, and to carry out a comparison between the geometry of the intrados surface and the evidences emerging at the extrados. The support of the laser scanner technique allows to accurately identify the surface profile and thickness. All these indications, in turn, are useful, in view of an interpretation of the structural behavior, to identify weaknesses, and to highlight contributing factors of instability (if any. The paper focuses on a well-documented case, the Magio Grasselli palace in Cremona in which the cloister vaults of two main rooms show different construction systems, although they were built almost at the same time. The thermographic recordings and laser-scanner surveys highlight the various arrangements used for the cloister vaults.

From the semicircular vault to the flattened vault in masonry bridges. The influence of rise/span ratio and the resistant backfill in the breaking load

Directory of Open Access Journals (Sweden)

J. R. Urruchi-Rojo

2017-04-01

Full Text Available The shape of the vaults in masonry bridges has evolved during the history, so that we can find bibliography where, besides recommending one way of build instead of others depending on the period, is also prescribed the way to carry out the backfill of the extrados. All of this emerged initially as a result of the experiences acquired during the construction and the observation of bridges. Hence, during the 18th century new formulations started to arise, but they led to one result in some cases and to the opposite in others. This article tries to make a comparison between some of these formulations, as well as carrying out an analysis of the influence of both, the lowering rise/span ratio of the vaults and the presence of a resistant backfill in its extrados, on the variation of the breaking load.

Cyclotrons and positron emitting radiopharmaceuticals

International Nuclear Information System (INIS)

Wolf, A.P.; Fowler, J.S.

1984-01-01

The state of the art of Positron Emission Tomography (PET) technology as related to cyclotron use and radiopharmaceutical production is reviewed. The paper discusses available small cyclotrons, the positron emitters which can be produced and the yields possible, target design, and radiopharmaceutical development and application. 97 refs., 12 tabs

A new cyclotron for biomedical research

International Nuclear Information System (INIS)

Wolber, G.

1988-01-01

This paper presents the rationale for replacing the old AEG Compact Cyclotron (built in 1969/71) of the Institute for Radiology and Pathophysiology at the German Cancer Research Center by a 30 MeV H - /15 MeV D - cyclotron. A status report is followed by the scientific and technical reasoning as well as budgetary and organizational considerations. In the appendix we tried to explain the function of a cyclotron in a simple and comprehensive manner. (orig.) [de

49 CFR 192.187 - Vaults: Sealing, venting, and ventilation.

Science.gov (United States)

2010-10-01

... explosive mixture might be ignited, and there must be a means for testing the internal atmosphere before removing the cover; (2) If the vault or pit is vented, there must be a means of preventing external sources... ventilating effect of a pipe 4 inches (102 millimeters) in diameter; (2) The ventilation must be enough to...

Cyclotron Phase-Coherent Ion Spatial Dispersion in a Non-Quadratic Trapping Potential is Responsible for FT-ICR MS at the Cyclotron Frequency

Science.gov (United States)

Nagornov, Konstantin O.; Kozhinov, Anton N.; Tsybin, Yury O.

2018-01-01

Fourier transform ion cyclotron resonance mass spectrometry (FT-ICR MS) at the cyclotron frequency instead of the reduced cyclotron frequency has been experimentally demonstrated using narrow aperture detection electrode (NADEL) ICR cells. Here, based on the results of SIMION simulations, we provide the initial mechanistic insights into the cyclotron frequency regime generation in FT-ICR MS. The reason for cyclotron frequency regime is found to be a new type of a collective motion of ions with a certain dispersion in the initial characteristics, such as pre-excitation ion velocities, in a highly non-quadratic trapping potential as realized in NADEL ICR cells. During ion detection, ions of the same m/z move in phase for cyclotron ion motion but out of phase for magnetron (drift) ion motion destroying signals at the fundamental and high order harmonics that comprise reduced cyclotron frequency components. After an initial magnetron motion period, ion clouds distribute into a novel type of structures - ion slabs, elliptical cylinders, or star-like structures. These structures rotate at the Larmor (half-cyclotron) frequency on a plane orthogonal to the magnetic field, inducing signals at the true cyclotron frequency on each of the narrow aperture detection electrodes. To eliminate the reduced cyclotron frequency peak upon dipolar ion detection, a number of slabs or elliptical cylinders organizing a star-like configuration are formed. In a NADEL ICR cell with quadrupolar ion detection, a single slab or an elliptical cylinder is sufficient to minimize the intensity of the reduced cyclotron frequency components, particularly the second harmonic. [Figure not available: see fulltext.

Cyclotrons and positron emitting radiopharmaceuticals

Energy Technology Data Exchange (ETDEWEB)

Wolf, A.P.; Fowler, J.S.

1984-01-01

The state of the art of Positron Emission Tomography (PET) technology as related to cyclotron use and radiopharmaceutical production is reviewed. The paper discusses available small cyclotrons, the positron emitters which can be produced and the yields possible, target design, and radiopharmaceutical development and application. 97 refs., 12 tabs. (ACR)

Ernest Orlando Lawrence (1901-1958), Cyclotron and Medicine

Energy Technology Data Exchange (ETDEWEB)

Chu, William T.

2005-09-01

, constructed a 13-cm diameter model that had all the features of early cyclotrons, accelerating protons to 80,000 volts using less than 1,000 volts on a semi-circular accelerating electrode, now called the ''dee''. Following the discovery by J. D. Cockcroft and E. T. S. Walton of how to produce larger currents at higher voltages, Lawrence constructed the first two-dee 27-Inch (69-cm) Cyclotron, which produced protons and deuterons of 4.8 MeV. The 27-Inch Cyclotron was used extensively in early investigations of nuclear reactions involving neutrons and artificial radioactivity. In 1939, working with William Brobeck, Lawrence constructed the 60-Inch (150-cm) Cyclotron, which accelerated deuterons to 19 MeV. It was housed in the Crocker Laboratory, where scientists first made transmutations of some elements, discovered several transuranic elements, and created hundreds of radioisotopes of known elements. At the Crocker Laboratory the new medical modality called nuclear medicine was born, which used radioisotopes for diagnosis and treatment of human diseases. In 1939 Lawrence was awarded the Nobel Prize in Physics, and later element 103 was named ''Lawrencium'' in his honor.

CLEARANCE OF ARCHIVE TAPE VAULT (BUILDING 186)

CERN Multimedia

EP Division

1999-01-01

The archive tape vault is being cleared to make way for the LHC experiments silicon facility.Experiments were contacted in February to arrange for the extended storage or destruction of archived volumes. Any who have not yet done so are asked to contactR. Minchin/IT immediately.This is also an opportunity to clear unused tapes or cartridges from around the site and have them destroyed ecologically. Please contact ep.smi.helpdesk@cern.ch to arrange for collection.A.E. Ball/EP-SMI

Expression and proteasomal degradation of the major vault protein (MVP) in mammalian oocytes and zygotes.

Science.gov (United States)

Sutovsky, Peter; Manandhar, Gaurishankar; Laurincik, Jozef; Letko, Juraj; Caamaño, Jose Nestor; Day, Billy N; Lai, Liangxue; Prather, Randall S; Sharpe-Timms, Kathy L; Zimmer, Randall; Sutovsky, Miriam

2005-03-01

Major vault protein (MVP), also called lung resistance-related protein is a ribonucleoprotein comprising a major part (>70%) of the vault particle. The function of vault particle is not known, although it appears to be involved in multi-drug resistance and cellular signaling. Here we show that MVP is expressed in mammalian, porcine, and human ova and in the porcine preimplantation embryo. MVP was identified by matrix-assisted laser-desorption ionization-time-of-flight (MALDI-TOF) peptide sequencing and Western blotting as a protein accumulating in porcine zygotes cultured in the presence of specific proteasomal inhibitor MG132. MVP also accumulated in poor-quality human oocytes donated by infertile couples and porcine embryos that failed to develop normally after in vitro fertilization or somatic cell nuclear transfer. Normal porcine oocytes and embryos at various stages of preimplantation development showed mostly cytoplasmic labeling, with increased accumulation of vault particles around large cytoplasmic lipid inclusions and membrane vesicles. Occasionally, MVP was associated with the nuclear envelope and nucleolus precursor bodies. Nucleotide sequences with a high degree of homology to human MVP gene sequence were identified in porcine oocyte and endometrial cell cDNA libraries. We interpret these data as the evidence for the expression and ubiquitin-proteasome-dependent turnover of MVP in the mammalian ovum. Similar to carcinoma cells, MVP could fulfill a cell-protecting function during early embryonic development.

Grout to meet physical and chemical requirements for closure at Hanford grout vaults. Final report

International Nuclear Information System (INIS)

1994-01-01

The US Army Engineer Waterways Experiment Station (WES) developed a grout based on portland cement, Class F fly ash, and bentonite clay, for the Hanford Grout Vault Program. The purpose of this grout was to fill the void between a wasteform containing 106-AN waste and the vault cover blocks. Following a successful grout development program, heat output, volume change, and compressive strength were monitored with time in simulated repository conditions and in full-depth physical models. This research indicated that the cold-cap grout could achieve and maintain adequate volume stability and other required physical properties in the internal environment of a sealed vault. To determine if contact with 106-AN liquid waste would cause chemical deterioration of the cold-cap grout, cured specimens were immersed in simulated waste. Over a period of 21 days at 150 F, specimens increased in mass without significant changes in volume. X-ray diffraction of reacted specimens revealed crystallization of sodium aluminum silicate hydrate. Scanning electron microscopy used with X-ray fluorescence showed that clusters if this phase had formed in grout pores, increasing grout density and decreasing its effective porosity. Physical and chemical tests collectively indicate a sealing component. However, the Hanford Grout Vault Program was cancelled before completion of this research. This report summarizes close-out Waterways Experiment Station when the Program was cancelled

Grout for closure of the demonstration vault at the US DOE Hanford Facility. Final report

International Nuclear Information System (INIS)

Wakeley, L.D.; Ernzen, J.J.

1992-08-01

The Waterways Experiment Station (WES) developed a grout to be used as a cold- (nonradioactive) cap or void-fill grout between the solidified low-level waste and the cover blocks of a demonstration vault for disposal of phosphate-sulfate waste (PSW) at the US Department of Energy (DOE) Hanford Facility. The project consisted of formulation and evaluation of candidate grouts and selection of the best candidate grout, followed by a physical scale-model test to verify grout performance under project-specific conditions. Further, the project provided data to verify numerical models (accomplished elsewhere) of stresses and isotherms inside the Hanford demonstration vault. Evaluation of unhardened grout included obtaining data on segregation, bleeding, flow, and working time. For hardened grout, strength, volume stability, temperature rise, and chemical compatibility with surrogate wasteform grout were examined. The grout was formulated to accommodate unique environmental boundary conditions (vault temperature = 45 C) and exacting regulatory requirements (mandating less than 0.1% shrinkage with no expansion and no bleeding); and to remain pumpable for a minimum of 2 hr. A grout consisting of API Class H oil-well cement, an ASTM C 618 Class F fly ash, sodium bentonite clay, and a natural sand from the Hanford area met performance requirements in laboratory studies. It is recommended for use in the DOE Hanford demonstration PSW vault

Development of the RF cavity for the SKKUCY-9 compact cyclotron

International Nuclear Information System (INIS)

Shin, Seungwook; Lee, Jongchul; LEE, Byeong-No; Ha, Donghyup; Namgoong, Ho; Chai, Jongseo

2015-01-01

A 9 MeV compact cyclotron, named SKKUCY-9, for a radiopharmaceutical compound especially fludeoxyglucose (FDG) production for a positron emission tomography (PET) machine was developed at Sungkyunkwan University. H − ions which are produced from a Penning Ionization Gauge(PIG) ion source, travel through a normal conducting radio frequency (RF) cavity which operates at 83.2 MHz for an acceleration and electro-magnet for a beam focusing until the ions acquire energy of about 9 MeV. For installation at a small local hospital, our SKKUCY-9 cyclotron is developed to be compact and light-weight, comparable to conventional medical purpose cyclotrons. For compactness, we adapted a deep valley and large angle hill type for the electro-magnet design. Normally a RF cavity is installed inside of the empty space of the magnet valley region, which is extremely small in our case. We faced problems such as difficulties of installing the RF cavity, low Q-value. Despite of those difficulties, a compact RF cavity and its system including a RF power coupler to feed amplified RF power to the RF cavity and a fine tuner to compensate RF frequency variations was successfully developed and tested

Development of the RF cavity for the SKKUCY-9 compact cyclotron

Science.gov (United States)

Shin, Seungwook; Lee, Jongchul; LEE, Byeong-No; Ha, Donghyup; Namgoong, Ho; Chai, Jongseo

2015-09-01

A 9 MeV compact cyclotron, named SKKUCY-9, for a radiopharmaceutical compound especially fludeoxyglucose (FDG) production for a positron emission tomography (PET) machine was developed at Sungkyunkwan University. H- ions which are produced from a Penning Ionization Gauge(PIG) ion source, travel through a normal conducting radio frequency (RF) cavity which operates at 83.2 MHz for an acceleration and electro-magnet for a beam focusing until the ions acquire energy of about 9 MeV. For installation at a small local hospital, our SKKUCY-9 cyclotron is developed to be compact and light-weight, comparable to conventional medical purpose cyclotrons. For compactness, we adapted a deep valley and large angle hill type for the electro-magnet design. Normally a RF cavity is installed inside of the empty space of the magnet valley region, which is extremely small in our case. We faced problems such as difficulties of installing the RF cavity, low Q-value. Despite of those difficulties, a compact RF cavity and its system including a RF power coupler to feed amplified RF power to the RF cavity and a fine tuner to compensate RF frequency variations was successfully developed and tested.

Vaginal vault drainage after complicated single-port access laparoscopic-assisted vaginal hysterectomy

Directory of Open Access Journals (Sweden)

Soo-Jeong Lee

2017-05-01

Conclusion: Vaginal vault drainage could be a safe alternative that allows for the management of postoperative morbidity and retains the advantages of minimally invasive surgery after complicated SPA-LAVH.

Monitored Retrievable Storage conceptual system study: open cycle vault

International Nuclear Information System (INIS)

Smith, R.I.

1983-11-01

This report provides a modified description of the Open Cycle Vault Storage Concept which meets a specified set of requirements; an estimate of the costs of construction, operation, and decommissioning of the concepts; the costs required to expand the facility throughput and storage capability; and the life-cycle costs of the facility. 11 references, 23 figures, 35 tables

Cyclotron method for heavy ion acceleration

International Nuclear Information System (INIS)

Gikal, B.N.; Gul'bekyan, G.G.; Kutner, V.B.; Oganesyan, R.Ts.

1984-01-01

Studies on heavy ion beams in a wide range of masses (up to uranium) and energies disclose essential potential opportunities for solution of both fundamental scientific and significant economical problems. A cyclotron method for heavy ion acceleration is considered. Development of low and medium energy heavy ion accelerators is revealed. The design of a complex comprising two isochronous cyclotrons which is planned to be constrdcted 1n the JINR is described. The cyclotron complex includes the U-400 and the U-400 M cyclotrons and it is intended for acceleration of both 35-20 MeV/nucleon superheavy ions such as Xe-U and 120 MeV/nucleon light ions. Certain systems of the accelerators are described. Prospects of the U-400 and the U-400 M development are displayed

Novel Technique for the UX15 Cavern Vault Support System

CERN Document Server

Rammer, H

2000-01-01

The overall LHC project schedule requires the civil engineering work to begin before the final LEP shutdown. The new caverns for the ATLAS experiment will be built in and around the existing underground structures at point 1. In order to make the best possible use of the time available for the LHC civil engineering before the shutdown of LEP, a particular arrangement for the construction of the UX15 cavern vault has been developed. The basic concept of this arrangement consists of the excavation of the cavern top heading and the installation of the concrete vault immediately afterwards, prior to the subsequent bench excavation after LEP shutdown. A temporary support of the dead weight of the concrete roof will be achieved by the suspension of the roof by 38 no. pre-stressed ground anchors of 225 tons capacity each. This support system will work up to the construction of the cavern base slab and walls and the completion of the permanent concrete lining.

Solid targets for production of radioisotopes with cyclotron; Blancos solidos para produccion de radioisotopos con ciclotron

Energy Technology Data Exchange (ETDEWEB)

Paredes G, L.; Balcazar G, M. [Instituto Nacional de Investigaciones Nucleares, Direccion de Investigacion Tecnologica, A.P. 18-1027, 11801 Mexico D.F. (Mexico)

1999-07-01

The design of targets for production of radioisotopes and radiopharmaceuticals of cyclotron to medical applications requires a detailed analysis of several variables such as: cyclotron operation conditions, choice of used materials as target and their physicochemical characteristics, activity calculation, the yielding of each radioisotope by irradiation, the competition of nuclear reactions in function of the projectiles energy and the collision processes amongst others. The objective of this work is to determine the equations for the calculation for yielding of solid targets at the end of the proton irradiation. (Author)

Conceptual design of shaft seals for a nuclear waste disposal vault

Energy Technology Data Exchange (ETDEWEB)

NONE

1993-04-01

The concept of a disposal vault in the Canadian Shield for the effective isolation of nuclear fuel wastes is being assessed as part of the Canadian Nuclear Fuel Waste Management Program. The vault would be accessed from the surface by a number of shafts, which would likely penetrate the vault environment and intersect significant rock fractures and thereby form preferential pathways for the migration of radionuclides from the disposal area to the biosphere. Golder Associates were retained to conduct a conceptual design study of sealing and backfilling the shafts. The first volume of this report reviews current shaft sinking and lining technologies, and recommends the preferred construction methods for the shafts. Factors that could affect the design of a shaft seal system are reviewed, and a conceptual shaft seal is proposed. The second volume addresses the performance assessment of a shaft seal system. While there are no specific performance criteria against which to compare the anticipated containment characteristics of the shaft seal system proposed, the methodology developed for the performance assessment of the reference design should enable the design to be modified to meet performance criteria as they are developed. The report estimates that it will cost $133.7 million in 1986 Canadian dollars to seal three reference shafts, including $18 million for labour and equipment, $103.4 million for backfill and sealing materials, $9.5 million for project indirect costs, and $2.8 million project management. (author). 53 refs., 36 tabs., 43 figs.

Conceptual design of shaft seals for a nuclear waste disposal vault

International Nuclear Information System (INIS)

1993-04-01

The concept of a disposal vault in the Canadian Shield for the effective isolation of nuclear fuel wastes is being assessed as part of the Canadian Nuclear Fuel Waste Management Program. The vault would be accessed from the surface by a number of shafts, which would likely penetrate the vault environment and intersect significant rock fractures and thereby form preferential pathways for the migration of radionuclides from the disposal area to the biosphere. Golder Associates were retained to conduct a conceptual design study of sealing and backfilling the shafts. The first volume of this report reviews current shaft sinking and lining technologies, and recommends the preferred construction methods for the shafts. Factors that could affect the design of a shaft seal system are reviewed, and a conceptual shaft seal is proposed. The second volume addresses the performance assessment of a shaft seal system. While there are no specific performance criteria against which to compare the anticipated containment characteristics of the shaft seal system proposed, the methodology developed for the performance assessment of the reference design should enable the design to be modified to meet performance criteria as they are developed. The report estimates that it will cost $133.7 million in 1986 Canadian dollars to seal three reference shafts, including $18 million for labour and equipment, $103.4 million for backfill and sealing materials, $9.5 million for project indirect costs, and $2.8 million project management. (author). 53 refs., 36 tabs., 43 figs

Operational readiness review of the Low Level Waste vaults at Savannah River Site: A case study

International Nuclear Information System (INIS)

Ahmad, M.; McVay, C.; Venkatesh, S.

1994-01-01

Low Level radioactive Waste (LLW) at the Savannah River Site at Aiken, South Carolina, has traditionally been disposed of using engineered trenches in accordance with the guidelines and technology existing at the time. Recently, subgrade concrete vaults known as E-Area Vaults (EAV) have been constructed at SRS. The EAV project is a comprehensive effort for upgrading LLW disposal at SRS based on meeting the requirements of current Department of Energy (DOE) Orders, and addressing more stringent federal and state regulations. The EAV is a first of its kind state-of-the-art facility designed and built in the United States to receive LLW. Westinghouse Savannah River Company (WSRC) conducted an Operational Readiness Review (ORR) of the vaults prior to startup. The objective of the EAV ORR was to perform a comprehensive review of the operational readiness of the facilities per DOE guidelines including Defense Nuclear Facilities Safety Board (DNFSB) recommendations. This review included assessing construction of the vaults as per design, adequate approved procedures, and training of all the personnel associated with the facility operations. EAV ORR incorporated the lessons learned from other DOE ORRs, included DNFSB recommendations, used a graded approach, and utilized subject matter experts for each functional area of assessment

The effect of organic matter in clay sealing materials on the performance of a nuclear fuel waste disposal vault

International Nuclear Information System (INIS)

Oscarson, D.W.; Stroes-Gascoyne, S.; Cheung, S.C.H.

1986-12-01

The potential effect of organic matter in clay sealing materials on the performance of a nuclear fuel waste disposal vault was examined. The available data indicate that the engineering properties of clays are not significantly affected by the relatively low levels of organic matter (< 1.2 wt.%) present in the clay sealing materials. Complexing of radionuclides by organic substances that are released from the clay sealing materials or produced by microorganisms will likely inhibit rather than promote radionuclide mobility in the compacted sealing materials because of the relatively large size of organic complexing species. Decreasing the level of organic matter in the clay sealing materials will not eliminate microorganisms, and perhaps not decrease their numbers significantly, because chemolithotrophic microorganisms (microorganisms that utilize inorganic forms of C) will be present in a disposal vault. Furthermore, an examination of the nutrient budget in a disposal vault indicates that N, rather than C, will likely be the limiting nutrient for microbial growth. Finally, there is not suitable, proven method for decreasing the level of organic matter in the large amounts of clay needed to seal a vault. It is concluded that the organic matter present in the clay sealing material will not adversely affect the performance of a disposal vault

Solid targetry for compact cyclotrons

International Nuclear Information System (INIS)

Comor, J.

2004-01-01

In this presentation authors present experimental results of solid targetry for compact cyclotrons. It is concluded: Solid targetry is not restricted to large accelerator centers anymore; Small and medium scale radioisotope production is feasible with compact cyclotrons; The availability of versatile solid target systems is expected to boost the radiochemistry of 'exotic' positron emitters

Criticality design evaluation of the White Sands reactor building storage vault

International Nuclear Information System (INIS)

Philbin, J.S.; Nelson, W.E.

1979-03-01

This report describes the conceptual design and criticality evaluation of a storage vault for components of the fast pulse reactor at White Sands Missile Range. Criticality calculations were performed with the KENO-IV Monte Carlo code for various storage configurations in order to investigate the coupling between the portable reactor and storage arrays of spare reactor rings or other fissile components of similar mass. Abnormal conditions corresponding to pseudo--random arrays of the fuel components, as well as a number of flooded configurations, were also evaluated to assess criticality potential for highly unlikely situations. In a normal, dry configuration, the neutron self-multiplication factor, k/sub eff/, of the fully loaded 3 x 8 planar array plus the reactor is less than 0.87. A completely flooded vault was found to produce self-multiplication factors in excess of 1.2

The potential for vault-induced seismicity in nuclear fuel waste disposal: experience from Canadian mines

International Nuclear Information System (INIS)

Martin, C.D.; Chandler, N.A.

1996-12-01

A seismic event which causes damage to an underground opening is called a rockburst. Practical experience indicates that these damaging seismic events are associated with deep mines where extraction ratios are greater than 0.6. For the arrangement being considered by AECL for nuclear fuel waste disposal vaults, extraction ratios, for the room and pillar design, will be less than 0.3. At this extraction ratio the stress magnitudes will not be sufficient to induce seismic events that can damage the underground openings. Documented world-wide experience shows that unless the underground opening is very close to the source of a naturally occurring seismic event, such as an earthquake, the opening will also not experience any significant damage. Backfilling a disposal vault will improve its resistance to earthquake damage. Backfilling a disposal vault will also reduce the total convergence of the openings caused by thermal loads and hence minimize the potential for thermally-induced seismic events. (author)

Ponderomotive force near cyclotron resonance

Energy Technology Data Exchange (ETDEWEB)

Kono, Mitsuo; Sanuki, Heiji

1987-01-01

The ponderomotive force, which is involved in the excitation of macroscopic behaviors of plasma caused by wave motion, plays an important role in various non-linear wave motion phenomena. In the present study, equations for the pondermotive force for plasma in a uniform magnetic field is derived using a renormalization theory which is based on the Vlasov equation. It is shown that the pondermotive force, which diverges at the cyclotron resonence point according to adiabatic approximation, can be expressed by a non-divergent equation by taking into account the instability of the cyclotron orbit due to high-order scattering caused by a wave. This is related with chaotic particle behaviors near cyclotron resonance, where the pondermotive force is small and the diffusion process prevails. It is assumed here that the amplitude of the high-frequency electric field is not large and that the broadening of cyclotron levels is smaller than the distance between the levels. A global chaos will be created if the amplitude of the electric field becomes greater to allow the broadening to exceed the distance between the levels. (Nogami, K.).

Cyclotron transitions of bound ions

Science.gov (United States)

Bezchastnov, Victor G.; Pavlov, George G.

2017-06-01

A charged particle in a magnetic field possesses discrete energy levels associated with particle rotation around the field lines. The radiative transitions between these levels are the well-known cyclotron transitions. We show that a bound complex of particles with a nonzero net charge displays analogous transitions between the states of confined motion of the entire complex in the field. The latter bound-ion cyclotron transitions are affected by a coupling between the collective and internal motions of the complex and, as a result, differ from the transitions of a "reference" bare ion with the same mass and charge. We analyze the cyclotron transitions for complex ions by including the coupling within a rigorous quantum approach. Particular attention is paid to comparison of the transition energies and oscillator strengths to those of the bare ion. Selection rules based on integrals of collective motion are derived for the bound-ion cyclotron transitions analytically, and the perturbation and coupled-channel approaches are developed to study the transitions quantitatively. Representative examples are considered and discussed for positive and negative atomic and cluster ions.

Cyclotron for medicine and research; Zyklotron fuer Medizin und Forschung

Energy Technology Data Exchange (ETDEWEB)

Anon.

2012-11-01

35 tons, weighs the major medical device, which has been delivered in early may at the Julic campus. A heavy-duty crane hoisted the new compact cyclotron to its destination, an underground concrete bunker. There it will from summer 2013 produce radionuclides for the synthesis of radiopharmaca, by which it is possible among others to detect tumors, to pursue metabolic processes, and to investigate the mechanisms of action of drugs.

TARGET-DIRECTED RUNNING IN GYMNASTICS: THE ROLE OF THE SPRINGBOARD POSITION AS AN INFORMATIONAL SOURCE TO REGULATE HANDSPRINGS ON VAULT

Directory of Open Access Journals (Sweden)

T. Heinen

2011-11-01

Full Text Available Empirical evidence highlights the role of visual information to control gymnastics vaulting and thus neglects a stereotyped approach run. However, there is no evidence on which informational source this regulation is based on. The aim of this study was to examine the position of the springboard as an informational source in the regulation of the handspring on vault. The hypothesis tested was that the action of running towards the springboard brings about changes in the approach run kinematics and handspring kinematics that relate directly to the position of the springboard. Therefore, kinematics of N = 14 female expert gymnasts’ handsprings on vault and their approach runs were examined while manipulating the position of the springboard. The results revealed that expert gymnasts placed their feet on average in the same position on the springboard and adapted to the springboard position during the last three steps of the approach run. A smaller springboard distance to the front edge of the vaulting table resulted in a different hand placement on the vaulting table, a shorter first flight phase, a take-off angle closer to 90° and a longer second flight phase. Findings suggest that the position of the springboard is a relevant informational source in gymnastics vaulting. We state that knowledge about relationships between informational sources in the environment and the resulting regulatory processes in athletes may help coaches to develop specific training programmes in order to optimize performance in complex skills.

arXiv Cyclotrons: Magnetic Design and Beam Dynamics

CERN Document Server

Zaremba, Simon

Classical, isochronous, and synchro-cyclotrons are introduced. Transverse and longitudinal beam dynamics in these accelerators are covered. The problem of vertical focusing and iscochronism in compact isochronous cyclotrons is treated in some detail. Different methods for isochronization of the cyclotron magnetic field are discussed. The limits of the classical cyclotron are explained. Typical features of the synchro-cyclotron, such as the beam capture problem, stable phase motion, and the extraction problem are discussed. The main design goals for beam injection are explained and special problems related to a central region with an internal ion source are considered. The principle of a Penning ion gauge source is addressed. The issue of vertical focusing in the cyclotron centre is briefly discussed. Several examples of numerical simulations are given. Different methods of (axial) injection are briefly outlined. Different solutions for beam extraction are described. These include the internal target, extracti...

The Casa Pizano and the Construction of Light Vaults in Colombia. The Origin of a Modern Tradition

Directory of Open Access Journals (Sweden)

Julián García

2018-05-01

Full Text Available At the beginning of the 20th Century several buildings were covered with tile vaults all through Latin America. However, two houses designed and built by Le Corbusier (the Maisons Sarabhai (Ahmadabad 1955 and Jaoul (Paris 1955 have traditionally been considered the main influence for later vaulted buildings covered with this technique in the area in the 60s and 70s. Since there were built examples contemporary or previous to the buildings by the Swiss architect, it seems logical to think that the influence of the Jaoul or Sarabhai houses in Latin American vault construction might have been somehow less relevant. There are several examples that support that idea: the most relevant is the Casa Pizano, a missing Bogota building designed by the local architect Francisco Pizano de Brigard, which was Le Corbusier's main inspiration for the aforementioned houses. The hypothesis of this paper is that local networks were also essential in the task of connecting similar technical initiatives regarding vault construction. To verify this hypothesis, several examples of buildings from different Latin American countries, starting from the Casa Pizano, will be studied, and some possible contacts between architects will be proposed.

A THERMAL MODEL OF THE IMMOBILIZATION OF LOW-LEVEL RADIOACTIVE WASTE AS GROUT IN CONCRETE VAULTS

Energy Technology Data Exchange (ETDEWEB)

Shadday, M

2008-10-27

Salt solution will be mixed with cement and flyash/slag to form a grout which will be immobilized in above ground concrete vaults. The curing process is exothermic, and a transient thermal model of the pouring and curing process is herein described. A peak temperature limit of 85 C for the curing grout restricts the rate at which it can be poured into a vault. The model is used to optimize the pouring.

Synchro-cyclotron

CERN Multimedia

CERN PhotoLab

1972-01-01

The electromagnetic coil which forms the first section of the proton extraction channel in the improved synchro-cyclotron. The photograph shows the positioning gear and the current septum. An extraction efficiency above 50% is expected.

One year's experience of the WA medical cyclotron and radiopharmaceutical production facility

International Nuclear Information System (INIS)

DeRoach, J.; Tuchyna, T.; Jones, C.; Price, R.

2004-01-01

Full text: The WA PET Centre Medical Cyclotron, a facility novel in Western Australia, produced its first bolus of FDG for patient injection for PET scanning in August 2003. This paper describes the methodology and practices employed during the past 12 months for ensuring that reliable routine provision of FDG is maintained, in parallel with facilitating the development and production of achievable new radiopharmaceuticals. An FDG production team of six staff and, a maintenance and development team of 4 staff were created from the 3.4 staff specifically recruited for this service and from incumbent staff. Teams were also set up to carry out development projects related to the service. Training procedures were created under the department's ISO9001:2000 accreditation system for the certification of production and maintenance staff. Practices and documentation systems were put in place in anticipation of a pending cGMP audit. Several unplanned major changes to equipment and infrastructure were necessary post commissioning. These changes included purchase of a different FDG synthesis module from that originally supplied, and modifications to engineering services, including changes to air conditioning, changes to supply of vacuum and upgrading of drainage in the laboratory area. A device for the measurement of end of bombardment yield was built, so that the efficiencies of the various synthesis modules could be accurately determined. Strict radiation protection procedures were put in place. All staff were provided with luxels and finger TLDs for monthly reporting of their radiation levels, as well as electronic monitors for real-time monitoring. From August 2003 to June 2004 (11 months) 2229 FDG patient doses were produced and dispensed by this facility. An average of 8.0 patient doses per available working day were dispensed during the 2003 period, rising to 11.1 patient doses per day in 2004. Several 11 NH3 doses were also delivered. The cyclotron was unavailable for

Compact superconducting cyclotron C400 for hadron therapy

Energy Technology Data Exchange (ETDEWEB)

Jongen, Y.; Abs, M.; Blondin, A.; Kleeven, W.; Zaremba, S.; Vandeplassche, D. [IBA, Chemin du Cyclotron 3, B-1348 Louvain-la-Neuve (Belgium); Aleksandrov, V.; Gursky, S.; Karamyshev, O. [JINR, Joliot-Curie 6, 141980 Dubna, Moscow region (Russian Federation); Karamysheva, G., E-mail: gkaram@nu.jinr.r [JINR, Joliot-Curie 6, 141980 Dubna, Moscow region (Russian Federation); Kazarinov, N.; Kostromin, S.; Morozov, N.; Samsonov, E.; Shirkov, G.; Shevtsov, V.; Syresin, E.; Tuzikov, A. [JINR, Joliot-Curie 6, 141980 Dubna, Moscow region (Russian Federation)

2010-12-01

The compact superconducting isochronous cyclotron C400 has been designed by the IBA-JINR collaboration. It will be the first cyclotron in the world capable of delivering protons, carbon and helium ions for cancer treatment. The cyclotron construction is started this year within the framework of the Archade project (Caen, France). {sup 12}C{sup 6+} and {sup 4}He{sup 2+} ions will be accelerated to 400 MeV/uu energy and extracted by the electrostatic deflector, H{sub 2}{sup +} ions will be accelerated to the energy of 265 MeV/uu and extracted by stripping. The magnet yoke has a diameter of 6.6 m, the total weight of the magnet is about 700 t. The designed magnetic field corresponds to 4.5 T in the hills and 2.45 T in the valleys. Superconducting coils will be enclosed in a cryostat; all other parts of the cyclotron will be warm. Three external ion sources will be mounted on the switching magnet on the injection line located below the cyclotron. The main parameters of the cyclotron, its design, the current status of the development work on the cyclotron systems are presented.

Advanced Accelerators for Medical Applications

Science.gov (United States)

Uesaka, Mitsuru; Koyama, Kazuyoshi

We review advanced accelerators for medical applications with respect to the following key technologies: (i) higher RF electron linear accelerator (hereafter “linac”); (ii) optimization of alignment for the proton linac, cyclotron and synchrotron; (iii) superconducting magnet; (iv) laser technology. Advanced accelerators for medical applications are categorized into two groups. The first group consists of compact medical linacs with high RF, cyclotrons and synchrotrons downsized by optimization of alignment and superconducting magnets. The second group comprises laser-based acceleration systems aimed of medical applications in the future. Laser plasma electron/ion accelerating systems for cancer therapy and laser dielectric accelerating systems for radiation biology are mentioned. Since the second group has important potential for a compact system, the current status of the established energy and intensity and of the required stability are given.

Estimation of induced activity in super conducting cyclotron at VECC: Monte Carlo calculations

International Nuclear Information System (INIS)

Chatterjee, S.; Bandyopadhyay, T.

2011-01-01

Super Conducting Cyclotron (K500) at Variable Energy Cyclotron Centre, Kolkata (VECC) is at an advanced stage of commissioning and has successfully delivered many internal beams (light to heavy particles) up to the extraction radius. One of the external beam lines has already been completed and commissioned. The SCC along with the other subsystems is getting ready to deliver beam for experiments. Beam loss of during beam tuning and also during a steady beam delivery to the different experimental facilities due to many operational factors and requirements. Extraction of beam from the machine to the beam line is also a major player for the loss of beam. The interaction of the lost beam of accelerated charge particles with the machine parts will undergo different nuclear reaction and induced activity will be produced at the different parts of the machine. Moreover secondary neutrons produced having energy maximum limiting to the beam energy will also produce radioactivity in the different parts of the machine as well it will also induce radioactivity on the radiation shield constructed around the accelerator. Radio-activation of different parts of an accelerator, radiation shield walls around the machine and materials available in the room poses a radiation hazard inside the machine vault and experimental caves especially during maintenance of the machine. During the shutdown and maintenance period of the machine occupational workers will be exposed to these induced activity produced during operation of the machine. An effort was made to estimate these residual activity and dose for 80 MeV proton bombarded on Stainless Steel thereon activity produced on different materials like Cu, Al, Concrete and SS of different thickness. Cu, Al, SS are among many other materials which are widely used for fabrication of any accelerator. A simulation of the scenario was created using a Monte Carlo approach using FLUKA 2006.3b-general purpose multi particle transport code. Estimation

Cyclotron Production of Technetium-99m

Science.gov (United States)

Gagnon, Katherine M.

Technetium-99m (99mTc) has emerged as the most widely used radionuclide in medicine and is currently obtained from a 99Mo/ 99mTc generator system. At present, there are only a handful of ageing reactors worldwide capable of producing large quantities of the parent isotope, 99Mo, and owing to the ever growing shutdown periods for maintenance and repair of these ageing reactors, the reliable supply 99mTc has been compromised in recent years. With an interest in alternative strategies for producing this key medical isotope, this thesis focuses on several technical challenges related to the direct cyclotron production of 99mTc via the 100Mo(p,2n)99mTc reaction. In addition to evaluating the 100Mo(p,2n)99mTc and 100Mo(p,x)99Mo reactions, this work presented the first experimental evaluation of the 100Mo(p,2n) 99gTc excitation function in the range of 8-18 MeV. Thick target calculations suggested that large quantities of cyclotron-produced 99mTc may be possible. For example, a 6 hr irradiation at 500 μA with an energy window of 18→10 MeV is expected to yield 1.15 TBq of 99mTc. The level of coproduced 99gTc contaminant was found to be on par with the current 99Mo/99mTc generator standard eluted with a 24 hr frequency. Highly enriched 100Mo was required as the target material for 99mTc production and a process for recycling of this expensive material is presented. An 87% recovery yield is reported, including metallic target preparation, irradiation, 99mTc extraction, molybdate isolation, and finally hydrogen reduction to the metal. Further improvements are expected with additional optimization experiments. A method for forming structurally stable metallic molybdenum targets has also been developed. These targets are capable of withstanding more than a kilowatt of beam power and the reliable production and extraction of Curie quantities of 99mTc has been demonstrated. With the end-goal of using the cyclotron-produced 99mTc clinically, the quality of the cyclotron

A light, superconducting H- cyclotron for medical diagnostics and neutron radiography

International Nuclear Information System (INIS)

Finlan, M.F.; Kruip, M.; Wilson, M.N.

1987-01-01

Oxford Instruments, working in close collaboration with Amersham International are developing a compact, lightweight, low radiation field superconducting cyclotron. The combination of superconductivity, H - acceleration and no internal yoke as such makes this possible. It is intended for use as a generator of short half lived isotopes for use in hospitals for PET and other imaging procedures, for use in industrial PET imaging, and as a neutron generator for neutron radiography. With a weight of 2000 kg, it is transportable and comparitively easy to handle and is capable in the 17 MeV version of generating 1.8 10 13 neutrons/second for neutron radiography. (author)

Status report on cyclotron operation

International Nuclear Information System (INIS)

Kovacs, P.; Szuecs, I.; Ander, I.; Lakatos, T.; Fenyvesi, A.; Ditroi, F.; Takacs, S.; Tarkanyi, F.

2004-01-01

The operation of the cyclotron in 2003 was again concentrated to 9 months; January, July and August were reserved for maintenance, renewal works and holidays. The overall working time of the accelerator was 4051 hours. The cyclotron was available for users for 3682 hours. In order to improve the circumstances of the irradiations renewal and improvements were done. (N.T.)

Global ex-situ crop diversity conservation and the Svalbard Global Seed Vault: assessing the current status.

Directory of Open Access Journals (Sweden)

Ola T Westengen

Full Text Available Ex-situ conservation of crop diversity is a global concern, and the development of an efficient and sustainable conservation system is a historic priority recognized in international law and policy. We assess the completeness of the safety duplication collection in the Svalbard Global Seed Vault with respect to data on the world's ex-situ collections as reported by the Food and Agriculture Organization of the United Nations. Currently, 774,601 samples are deposited at Svalbard by 53 genebanks. We estimate that more than one third of the globally distinct accessions of 156 crop genera stored in genebanks as orthodox seeds are conserved in the Seed Vault. The numbers of safety duplicates of Triticum (wheat, Sorghum (sorghum, Pennisetum (pearl millet, Eleusine (finger millet, Cicer (chickpea and Lens (lentil exceed 50% of the estimated numbers of distinct accessions in global ex-situ collections. The number of accessions conserved globally generally reflects importance for food production, but there are significant gaps in the safety collection at Svalbard in some genera of high importance for food security in tropical countries, such as Amaranthus (amaranth, Chenopodium (quinoa, Eragrostis (teff and Abelmoschus (okra. In the 29 food-crop genera with the largest number of accessions stored globally, an average of 5.5 out of the ten largest collections is already represented in the Seed Vault collection or is covered by existing deposit agreements. The high coverage of ITPGRFA Annex 1 crops and of those crops for which there is a CGIAR mandate in the current Seed Vault collection indicates that existence of international policies and institutions are important determinants for accessions to be safety duplicated at Svalbard. As a back-up site for the global conservation system, the Seed Vault plays not only a practical but also a symbolic role for enhanced integration and cooperation for conservation of crop diversity.

Global ex-situ crop diversity conservation and the Svalbard Global Seed Vault: assessing the current status.

Science.gov (United States)

Westengen, Ola T; Jeppson, Simon; Guarino, Luigi

2013-01-01

Ex-situ conservation of crop diversity is a global concern, and the development of an efficient and sustainable conservation system is a historic priority recognized in international law and policy. We assess the completeness of the safety duplication collection in the Svalbard Global Seed Vault with respect to data on the world's ex-situ collections as reported by the Food and Agriculture Organization of the United Nations. Currently, 774,601 samples are deposited at Svalbard by 53 genebanks. We estimate that more than one third of the globally distinct accessions of 156 crop genera stored in genebanks as orthodox seeds are conserved in the Seed Vault. The numbers of safety duplicates of Triticum (wheat), Sorghum (sorghum), Pennisetum (pearl millet), Eleusine (finger millet), Cicer (chickpea) and Lens (lentil) exceed 50% of the estimated numbers of distinct accessions in global ex-situ collections. The number of accessions conserved globally generally reflects importance for food production, but there are significant gaps in the safety collection at Svalbard in some genera of high importance for food security in tropical countries, such as Amaranthus (amaranth), Chenopodium (quinoa), Eragrostis (teff) and Abelmoschus (okra). In the 29 food-crop genera with the largest number of accessions stored globally, an average of 5.5 out of the ten largest collections is already represented in the Seed Vault collection or is covered by existing deposit agreements. The high coverage of ITPGRFA Annex 1 crops and of those crops for which there is a CGIAR mandate in the current Seed Vault collection indicates that existence of international policies and institutions are important determinants for accessions to be safety duplicated at Svalbard. As a back-up site for the global conservation system, the Seed Vault plays not only a practical but also a symbolic role for enhanced integration and cooperation for conservation of crop diversity.

Production of radiopharmaceuticals by cyclotrons

International Nuclear Information System (INIS)

Schmitz, F.; Van Naemen, J.; Monclus, M.; Van Gansbeke, B.; Kadiata, M.; Ekelmans, D.; Moray, M.; Penninckx, R.; Goldman, S.

2004-01-01

Companies specialized in the development and installation of accelerator-based systems dedicated to the medical applications brought on the market cyclotrons well fitted to the requests of the industrial community or universities and so covering every segment of the market. These machines are fully automatic, and need reduced maintenance; they are highly specialized for defined tasks. They can produce high beam intensity and realize dual beam irradiation. Also the prices are reducing considerably. The targets and the automatic system follow the same trend. Unfortunately, the flexibility of these devices for new area of research and development has been dramatically reduced. The growing number of PET cameras has increased the popularity of PET tracers used for nuclear imaging. Consequently, there is a growing demand for these radiopharmaceuticals compounds labeled with short-lived radioisotopes for clinical applications. From a research and development tool in the eighties, PET has now grown up to a clinical tool. Moreover, depending of the social welfare, reimbursement of some PET examinations is granted, which accelerates the trend for an extended use of PET tracers. Regulatory affairs try to establish and standardize the control on these radiopharmaceutical compounds produced in a growing number of local radio pharmacies owning a baby cyclotron. On the other hand, the attention of equipment suppliers was brought in the setting up of a total quality control follow up. These efforts were successively achieved by getting for instance the ISO 9001 certificate

Slow wave cyclotron maser

International Nuclear Information System (INIS)

Kho, T.H.; Lin, A.T.

1988-01-01

Cyclotron masers such as Gyrotrons and the Autoresonance Masers, are fast wave devices: the electromagnetic wave's phase velocity v rho , is greater than the electron beam velocity, v b . To be able to convert the beam kinetic energy into radiation in these devices the beam must have an initial transverse momentum, usually obtained by propagating the beam through a transverse wiggler magnet, or along a nonuniform guide magnetic field before entry into the interaction region. Either process introduces a significant amount of thermal spread in the beam which degrades the performance of the maser. However, if the wave phase velocity v rho v b , the beam kinetic energy can be converted directly into radiation without the requirement of an initial transverse beam momentum, making a slow wave cyclotron maser a potentially simpler and more compact device. The authors present the linear and nonlinear physics of the slow wave cyclotron maser and examine its potential for practical application

A lime based mortar for thermal insulation of medieval church vaults

DEFF Research Database (Denmark)

Larsen, P.K.; Hansen, Tessa Kvist

A new mortar for thermal insulation of medieval church vaults was tested in a full scale experiment in Annisse Church, DK. The mortar consists of perlite, a highly porous aggregate, mixed with slaked lime. These materials are compatible with the fired clay bricks and the lime mortar joints....... The lambda-value of the insulation mortar is 0.08 W/m K or twice the lambda-value for mineral wool. The water vapour permeability is equal to a medieval clay brick, and it has three times higher capacity for liquid water absorption. The mortar was applied to the top side of the vaults in a thickness of 10 cm......, despite a water vapour pressure gradient up to 500 Pa between the nave and attic. There was no reduction in energy consumption the first winter, possibly due to the increased heat loss related to the drying of the mortar....

Quality assurance plan for placement of cold-cap grout, demonstration vault, Hanford Grout Vault Program. Final report

Energy Technology Data Exchange (ETDEWEB)

Harrington, P.T.; Wakeley, L.D.; Ernzen, J.J.; Walley, D.M.

1992-08-01

During FY 91, the U.S. Army Engineer Waterways Experiment Station (WES) developed a grout to be used as a cold cap, a nonradioactive layer, between the solidified waste and the cover blocks of a demonstration waste disposal vault at the U.S. Department of Energy Hanford Facility. This document recommends requirements for a quality assurance (QA) plan for field mixing and placing of the cold-cap grout during final closure of the demonstration vault. Preplacement activities emphasize selection and testing of materials that will match the performance of materials used in the WES grout. Materials sources and applicable American Society of Testing and Materials, American Concrete Institute, and American Petroleum Institute specifications and requirements are provided. Archiving of physical samples of materials is essential, in addition to careful maintenance of test reports and laboratory data. Full-scale field trial mixing and a detailed preconstruction conference are recommended. Placement activities focus on production and placement of a grout that remains sufficiently constant throughout all batches and meets performance requirements. QA activities must be coordinated between the batch plant and delivery site. Recommended sampling during placement includes cylinders cast for subsequent tests of compressive strength and for nondestructive evaluation and prisms cast for monitoring volume stability. A minimum of two lifts is recommended. Postplacement activities include long-term monitoring of the properties of grout specimens cast during placement. Minimum testing of cylinders includes pulse velocity, fundamental frequency, and unconfined compressive strength. Monitoring characteristics of the microstructure also are recommended. The QA plan should designate an organization to have responsibility for maintaining complete records, reports, and archived samples, including details of deviations from plans written before field placement.

Giant osteoma of the skull vault: A rare case of mixed variety

Directory of Open Access Journals (Sweden)

Harisha P.N.

2016-12-01

Full Text Available Osteoma is the most common primary bone tumor in the craniofacial skeleton. However, most of these are small, asymptomatic and arise from the facial bones or in relation to the paranasal sinuses. Cranial vault osteomas, that too giant and symptomatic are much rarer. We report a case of sixty year-old gentleman presented with a very slowly increasing, painless, hard swelling on the left side of his head. Computerized tomography scan showed the left parietal calvarial tumor to be having large exostotic and enostotic components. He underwent an en-bloc excision of the tumor and cranioplasty. Giant, symptomatic cranial vault osteoma with concurrent exostotic and enostotic components is extremely rare. These lesions can be safely and completely excised with careful planning and attention to detail.

Recruitment of the major vault protein by InlK: a Listeria monocytogenes strategy to avoid autophagy.

Directory of Open Access Journals (Sweden)

Laurent Dortet

2011-08-01

Full Text Available L. monocytogenes is a facultative intracellular bacterium responsible for listeriosis. It is able to invade, survive and replicate in phagocytic and non-phagocytic cells. The infectious process at the cellular level has been extensively studied and many virulence factors have been identified. Yet, the role of InlK, a member of the internalin family specific to L. monocytogenes, remains unknown. Here, we first show using deletion analysis and in vivo infection, that InlK is a bona fide virulence factor, poorly expressed in vitro and well expressed in vivo, and that it is anchored to the bacterial surface by sortase A. We then demonstrate by a yeast two hybrid screen using InlK as a bait, validated by pulldown experiments and immunofluorescence analysis that intracytosolic bacteria via an interaction with the protein InlK interact with the Major Vault Protein (MVP, the main component of cytoplasmic ribonucleoproteic particules named vaults. Although vaults have been implicated in several cellular processes, their role has remained elusive. Our analysis demonstrates that MVP recruitment disguises intracytosolic bacteria from autophagic recognition, leading to an increased survival rate of InlK over-expressing bacteria compared to InlK(- bacteria. Together these results reveal that MVP is hijacked by L. monocytogenes in order to counteract the autophagy process, a finding that could have major implications in deciphering the cellular role of vault particles.

EFFECTS OF RUN-UP VELOCITY ON PERFORMANCE, KINEMATICS, AND ENERGY EXCHANGES IN THE POLE VAULT

Directory of Open Access Journals (Sweden)

Nicholas P. Linthorne

2012-06-01

Full Text Available This study examined the effect of run-up velocity on the peak height achieved by the athlete in the pole vault and on the corresponding changes in the athlete's kinematics and energy exchanges. Seventeen jumps by an experienced male pole vaulter were video recorded in the sagittal plane and a wide range of run-up velocities (4.5-8.5 m/s was obtained by setting the length of the athlete's run-up (2-16 steps. A selection of performance variables, kinematic variables, energy variables, and pole variables were calculated from the digitized video data. We found that the athlete's peak height increased linearly at a rate of 0.54 m per 1 m/s increase in run-up velocity and this increase was achieved through a combination of a greater grip height and a greater push height. At the athlete's competition run-up velocity (8.4 m/s about one third of the rate of increase in peak height arose from an increase in grip height and about two thirds arose from an increase in push height. Across the range of run-up velocities examined here the athlete always performed the basic actions of running, planting, jumping, and inverting on the pole. However, he made minor systematic changes to his jumping kinematics, vaulting kinematics, and selection of pole characteristics as the run-up velocity increased. The increase in run-up velocity and changes in the athlete's vaulting kinematics resulted in substantial changes to the magnitudes of the energy exchanges during the vault. A faster run-up produced a greater loss of energy during the take-off, but this loss was not sufficient to negate the increase in run-up velocity and the increase in work done by the athlete during the pole support phase. The athlete therefore always had a net energy gain during the vault. However, the magnitude of this gain decreased slightly as run-up velocity increased

Development of a low-level RF control system for PET cyclotron CYCIAE-14

Energy Technology Data Exchange (ETDEWEB)

Li, Pengzhan, E-mail: lipengzhan@ciae.ac.cn; Yin, Zhiguo; Ji, Bin; Zhang, Tianjue; Zhao, Zhenlu

2014-01-21

The project of a 14 MeV PET cyclotron aiming at medical diagnosis and treatment was proposed and started at CIAE in 2010. The low-level RF system is designed to stabilize acceleration voltage and control the resonance of the cavity. Based on the experience of the existing CRM Cyclotron in CIAE, a new start-up sequence is developed and tested. The frequency sweeping is used to activate the RF system. Before the tuner is put into use, a new state called “DDS tuning” is applied to trace the resonance frequency to the designed value. This new option state helps to cover the tuning range, if a large frequency variation occurs because of a thermal cavity deformation. The logic control unit detects the spark, reflection, Pulse/CW state and the frequency of the RF source to perform all kinds of protection and state operations. The test bench and on-line test are carried out to verify the initial design. -- Highlights: • The low-level RF system is designed and verified for PET cyclotron CYCIAE-14. • The frequency sweeping is used to activate the RF system. • A new state called “DDS tuning” is applied to trace the resonance frequency. • This new option state helps to cover the tuning range. • Protection module allows a quick restart after an alarm and improves cyclotron's efficiency.

Evaluation of the production capabilities of 18F, 11C, 13N and 15O PET isotopes at the PET-cyclotron-radiochemistry site of Messina University

OpenAIRE

Auditore, Lucrezia; Amato, Ernesto; Italiano, Antonio; Pagano, Benedetta; Baldari, Sergio

2017-01-01

The production of 18F, 11C, 13N, and 15O positron emitting radionuclides for PET imaging is usually accomplished in Nuclear Medicine Departments through direct nuclear reactions induced by protons accelerated by compact medical cyclotrons on liquid or gaseous targets. Messina University has funded the construction of a PET-cyclotron-radio-chemistry plant at the Messina University Hospital, equipped with a 11 MeV self-shielded cyclotron. We estimated the expected production yields of these nuc...

Isotope separation by ionic cyclotron resonance

International Nuclear Information System (INIS)

Compant La Fontaine, A.; Gil, C.; Louvet, P.

1986-10-01

The principle of the process of isotopic separation by ionic cyclotron resonance is explained succinctly. The theoretical calculation of the isotopic effect is given as functions of the electric and magnetic fields in the frame of single particle approximation and of plasma collective theory. Then, the main parts of the demonstration device which is in operation at the CEA, are described here: the supraconducting magnetic field, the used diagnostics, the principle of the source and the collecting apparatus. Some experimental results are given for chromium. The application of the process to ponderal separation of metal isotopes, as chromium, nickel and molybdenum is discussed in view of production of medical, structural and irradiation isotopes

PFP vault operations containers for Plutonium Handling and Storage Critical Characteristics

International Nuclear Information System (INIS)

BONADIE, E.P.

2000-01-01

This document specifies the critical characteristics for containers procured for Plutonium Finishing Plant's (PFP's) Vault Operations system as required by HNF-PRO-268 and HNF-PRO-1819. These are the minimum specifications that the equipment must meet in order to perform its safety function

Rf structure of superconducting cyclotron for therapy application

International Nuclear Information System (INIS)

Takekoshi, Hidekuni; Matsuki, Seishi; Mashiko, Katuo; Shikazono, Naomoto.

1981-01-01

Advantages of fast neutrons in therapeutical application are now widely recognized. Fast neutrons are generated by bombarding a thick beryllium target with high energy protons and deuterons. The AVF cyclotrons which deliver 50 MeV protons and 25 MeV deuterons are commonly used and are commercially available now. At the treatment usually rotational irradiation is taken to prevent an injury to normal tissue from the high LET effect of fast neutrons. The construction cost of both cyclotrons and isocentric irradiation installation are relatively high, so that the spread of neutron therapy is obstructed. A superconducting cyclotron for neutron therapy application was proposed by a Chalk River group. This low cost design allows the installation to be a dedicated facility located in a hospital, and small size allows installations of the complete cyclotron in a rotatable gantry. The design studies of the superconducting cyclotron based on this idea are going on at Kyoto University. The full scale model experiments for a rf structure of the cyclotron were carried out. (author)

Commissioning of cryogen delivery system for superconducting cyclotron magnet

International Nuclear Information System (INIS)

Pal, G.; Nandi, C.; Bhattacharyya, T.K.; Chaudhuri, J.; Bhandari, R.K.

2005-01-01

A K-500 superconducting cyclotron is being constructed at VECC Kolkata. The cryogen delivery system distributes liquid helium and liquid nitrogen to the superconducting cyclotron. Liquid helium is required to cool the cyclotron magnet and cryopanels. Liquid nitrogen is used to reduce the capacity of the helium liquefier. This paper describes the system, the current status and the commissioning experiences of cryogen delivery system for cyclotron magnet. (author)

Progress report: Variable Energy Cyclotron Centre, Calcutta

International Nuclear Information System (INIS)

1999-01-01

This volume of the progress report brings out the scientific and technical activities of Variable Energy Cyclotron Centre, Calcutta during the year 1999. This includes brief review of the various R and D activities of the Centre and outside users of the cyclotron from the universities and other research institutes. The operational activities of the cyclotron with ECR ion sources, accelerator oriented research activities, activities on detector, target and electronics are reported. The activities of the Computer and Informatics group are described. The status report of the ongoing projects is also provided. The main activities of the superconducting cyclotron project, radioactive ion beam project, heavy ion experimental facility, advanced computational facility, recovery and analysis of helium from hot springs and material science research are described

10 GHz ECRIS for Warsaw Cyclotron

CERN Document Server

Sudlitz, K

1999-01-01

Cusp type, 10 GHz ECRIS has been built and tested earlier. For obtaining intensive beams, more relevant for cyclotron, cusp geometry has been replaced by hexapole. Discharge chamber (stainless steel, 50 mm diameter, 250 mm long) is an extension of a coaxial line, feeding RF (9,6 GHz, up to 200 W) to the plasma. The NdFeB hexapole (0,52 T on the surface) has been used. The axial magnetic field is created by water cooled coils. The axial injection line dedicated to K160 isochronous heavy ion cyclotron has been constructed. The line consists of Glaser lenses, double focusing magnet, solenoid and mirror type inflector. The system provides sufficient transmission of the beam from ECR ion source to the firsts orbits of the cyclotron for m/q ranging from 7 to 2. After successful initial tests which were done in July 1997 the ECRIS serves as an external source for Warsaw Cyclotron.

Electron cyclotron harmonic wave acceleration

Science.gov (United States)

Karimabadi, H.; Menyuk, C. R.; Sprangle, P.; Vlahos, L.

1987-01-01

A nonlinear analysis of particle acceleration in a finite bandwidth, obliquely propagating electromagnetic cyclotron wave is presented. It has been suggested by Sprangle and Vlahos in 1983 that the narrow bandwidth cyclotron radiation emitted by the unstable electron distribution inside a flaring solar loop can accelerate electrons outside the loop by the interaction of a monochromatic wave propagating along the ambient magnetic field with the ambient electrons. It is shown here that electrons gyrating and streaming along a uniform, static magnetic field can be accelerated by interacting with the fundamental or second harmonic of a monochromatic, obliquely propagating cyclotron wave. It is also shown that the acceleration is virtually unchanged when a wave with finite bandwidth is considered. This acceleration mechanism can explain the observed high-energy electrons in type III bursts.

Electron cyclotron harmonic wave acceleration

International Nuclear Information System (INIS)

Karimabadi, H.; Menyuk, C.R.; Sprangle, P.; Vlahos, L.; Salonika Univ., Greece)

1987-01-01

A nonlinear analysis of particle acceleration in a finite bandwidth, obliquely propagating electromagnetic cyclotron wave is presented. It has been suggested by Sprangle and Vlahos in 1983 that the narrow bandwidth cyclotron radiation emitted by the unstable electron distribution inside a flaring solar loop can accelerate electrons outside the loop by the interaction of a monochromatic wave propagating along the ambient magnetic field with the ambient electrons. It is shown here that electrons gyrating and streaming along a uniform, static magnetic field can be accelerated by interacting with the fundamental or second harmonic of a monochromatic, obliquely propagating cyclotron wave. It is also shown that the acceleration is virtually unchanged when a wave with finite bandwidth is considered. This acceleration mechanism can explain the observed high-energy electrons in type III bursts. 31 references

83-inch cyclotron research program. Final report

International Nuclear Information System (INIS)

Parkinson, W.C.

1983-07-01

In June of 1960 the US Atomic Energy Commission authorized the construction of a modern variable energy cyclotron facility at The University of Michigan to be used for research in nuclear spectroscopy. The Legislature of the State of Michigan made available funds for construction of a building to house the 83-inch cyclotron and auxiliary equipment as well as the University's remodeled 42-inch cyclotron. The research program centered around the 83-inch cyclotron was funded by the AEC and its successors, the Energy Research and Development Administration (ERDA) and the Department of Energy (DOE), from September 1964 through March 1977. The program represented a continuation of the research effort using the 42-inch cyclotron facility which had been supported continuously by the AEC since February 1950. This final report to DOE briefly describes the research facility, the research program, and highlights the principal accomplishments of the effort. It begins with a historical note to place this effort within the context of nuclear physics research in the Department of Physics of the University of Michigan

Recycling and recommissioning a used biomedical cyclotron

International Nuclear Information System (INIS)

Carroll, L.R.; Ramsey, F.; Armbruster, J.; Montenero, M.

2001-01-01

Biomedical Cyclotrons have a very long life, but there eventually comes a time when any piece of equipment has to be retired from service. From time to time, we have the opportunity to help find new homes for used cyclotrons which, with relatively modest overhaul and refurbishment, can have many additional years of productive service, and thus represent a very valuable asset. The reasons for retiring a cyclotron vary, of course, but in our experience it is often due to an institution's changing priorities or changing needs, rather than the due to any fundamental age-related deficiency in the cyclotron itself. In this paper we will report on the relocation and successful restoration of a used TCC CP-42 cyclotron, which was moved from M.D. Anderson Hospital in Houston to Denton, Texas in early 1998, where it is presently being used for R and D and commercial production of biomedical isotopes. Ownership of the machine has been transferred to the University of North Texas; facility, manpower, and operational resources are provided by International Isotopes, Inc

Method and apparatuses for ion cyclotron spectrometry

Science.gov (United States)

Dahl, David A [Idaho Falls, ID; Scott, Jill R [Idaho Falls, ID; McJunkin, Timothy R [Idaho Falls, ID

2012-03-06

An ion cyclotron spectrometer may include a vacuum chamber that extends at least along a z-axis and means for producing a magnetic field within the vacuum chamber so that a magnetic field vector is generally parallel to the z-axis. The ion cyclotron spectrometer may also include means for producing a trapping electric field within the vacuum chamber. The trapping electric field may comprise a field potential that, when taken in cross-section along the z-axis, includes at least one section that is concave down and at least one section that is concave up so that ions traversing the field potential experience a net magnetron effect on a cyclotron frequency of the ions that is substantially equal to zero. Other apparatuses and a method for performing ion cyclotron spectrometry are also disclosed herein.

Cyclotron radiation by a multi-group method

International Nuclear Information System (INIS)

Chu, T.C.

1980-01-01

A multi-energy group technique is developed to study conditions under which cyclotron radiation emission can shift a Maxwellian electron distribution into a non-Maxwellian; and if the electron distribution is non-Maxwellian, to study the rate of cyclotron radiation emission as compared to that emitted by a Maxwellian having the same mean electron density and energy. The assumptions in this study are: the electrons should be in an isotropic medium and the magnetic field should be uniform. The multi-group technique is coupled into a multi-group Fokker-Planck computer code to study electron behavior under the influence of cyclotron radiation emission in a self-consistent fashion. Several non-Maxwellian distributions were simulated to compare their cyclotron emissions with the corresponding energy and number density equivalent Maxwellian distribtions

Low energy cyclotron for radiocarbon dating

International Nuclear Information System (INIS)

Welch, J.J.

1984-12-01

The measurement of naturally occurring radioisotopes whose half lives are less than a few hundred million years but more than a few years provides information about the temporal behavior of geologic and climatic processes, the temporal history of meteoritic bodies as well as the production mechanisms of these radioisotopes. A new extremely sensitive technique for measuring these radioisotopes at tandem Van de Graaff and cyclotron facilities has been very successful though the high cost and limited availability have been discouraging. We have built and tested a low energy cyclotron for radiocarbon dating similar in size to a conventional mass spectrometer. These tests clearly show that with the addition of a conventional ion source, the low energy cyclotron can perform the extremely high sensitivity 14 C measurements that are now done at accelerator facilities. We found that no significant background is present when the cyclotron is tuned to accelerate 14 C negative ions and the transmission efficiency is adequate to perform radiocarbon dating on milligram samples of carbon. The internal ion source used did not produce sufficient current to detect 14 C directly at modern concentrations. We show how a conventional carbon negative ion source, located outside the cyclotron magnet, would produce sufficient beam and provide for quick sampling to make radiocarbon dating milligram samples with a modest laboratory instrument feasible

Operation of the Karlsruhe Isochronous Cyclotron in 1975

International Nuclear Information System (INIS)

Schulz, F.; Schweickert, H.

1976-06-01

The operation of the Karlsruhe Isochronous Cyclotron in 1975 is briefly surveyed. The main reasons for a very short period for maintenance, repair and installation, and several additional efforts to improve the reliability of the accelerator installation, are discussed. The status and the results of several technical developments for the cyclotron are described: 1) the axial injection system; 2) computer aided cyclotron operation; 3) ion source development; 4) capacitive current measurement at the external beam; 5) new correction coils for the cyclotron; 6) improvement of the neutron time-of-flight spectrometer. As there is an increasing interest in using this type of accelerator for research in fields other than nuclear physics, it was felt appropriate to present short surveys on investigations at our cyclotron in 1975 in the fields of: 1) solid state physics; 2) engineering; 3) materials research; 4) nuclear medicine; 5) nuclear chemistry. (orig.) [de

Follow-up after repair of vaginal vault prolapse with abdominal colposacropexy

DEFF Research Database (Denmark)

Pilsgaard, K; Mouritsen, L

1999-01-01

BACKGROUND: Vaginal vault prolapse after hysterectomy is a rare complication, with a prevalence of less than 1/2%. The vaginal depth an axis can be restored by colposacropexy with preservation of coital function. The aim of this follow-up study was to assess the results of colposacropexy with spe...

Present and future superconducting cyclotrons

International Nuclear Information System (INIS)

Nolen, J.A. Jr.

1987-01-01

This paper begins with a brief review of the status of present superconducting (SC) cyclotron projects, including the two which are currently operating and the six which are under construction. The next section summarizes the main features shared by five of these machines, while the third section presents recent developments and new concepts introduced in the other three ''second generation'' SC cyclotrons. Projects in early stages of development are discussed in the fourth section

NIRS-Chiba isochronous cyclotron 1975

International Nuclear Information System (INIS)

Ogawa, H.; Kumamoto, Y.; Yamada, T.; Hiramoto, T.

1976-02-01

The cyclotron facility installed according to the recommendation of the Atomic Energy Committee of Japan is used for neutron therapy and production of short-lived radioisotopes. Construction on the facility was started in the autumn of 1972, and completed in March 1974. Described are the following: beam transport and the experimental hall, machine research and improvement, machine time sharing and the particles and energies, characteristics of the cyclotron, and facility personnel. (auth.)

Knowledge based operation assist system for JAERI AVF cyclotron

International Nuclear Information System (INIS)

Agematsu, T.; Okumura, S.; Yokota, W.; Arakawa, K.; Murakami, T.; Okamura, T.

1992-01-01

We have developed two operation assist systems for easy and rapid operation of the JAERI AVF cyclotron. One is a knowledge based expert system guiding the sequence of parameter adjustment to inexperienced cyclotron operators. The other is a real-time simulation of the beam trajectories which are calculated from actual operating parameters. It graphically indicates feasible setting range of parameters that satisfies the acceptance of the cyclotron. These systems provide a human interface to adjust the parameters of the cyclotron. (author)

Isochronous cyclotron for thermonuclear reactors driving

International Nuclear Information System (INIS)

Alenitskij, Yu.G.

1998-01-01

The main requirements to an accelerator as a part of an electronuclear power plant are considered. The range of the parameters of the accelerated proton and deuteron beams, for which the isochronous cyclotron is the most profitable, is proposed. An opportunity of using the cyclotron to drive the research reactors of various types is considered

A thermal model of the immobilization of low-level radioactive waste as grout in concrete vaults

International Nuclear Information System (INIS)

Shadday, Martin A.

2009-01-01

Salt solution, from radioactive waste generated by the production of plutonium and tritium in nuclear reactors at the Savannah River Site, will be mixed with cement and flyash/slag to form a grout which will be poured into above ground concrete vaults. The curing process is exothermic, and a transient thermal model of the pouring and curing process is herein described. A peak temperature limit of 85 o C for the curing grout restricts the rate at which it can be poured into a vault. The model is used to optimize the pouring.

Cyclotron to Oslo University

International Nuclear Information System (INIS)

Sandstad, J.

1978-01-01

The new cyclotron was delivered to Oslo University on September 21st 1978, and was mannfactured by A/B Scandtronix of Uppsala, Sweden. The contract price was 6,8 million Norwegian kroner and installation will cost a further 4 million. The main specifications are given. The energy will be 36 MeV for protons and alpha particles, 18 MeV deuterons and 48 MeV for helium 3. The principle of a cyclotron is briefly described. While the primary purpose of the machine is nuclear research it is also planned to produce short-lived radioisotopes, primarily iodine 123. (JIW)

Safety assessment for deep underground disposal vault-pathways analysis

International Nuclear Information System (INIS)

Lyon, R.B.; Rosinger, E.L.J.

1980-01-01

The concept verification phase of the Canadian programme for the disposal of nuclear fuel waste encompasses a period of about three years before the start of site selection. During this time, the methodology for Environmental and Safety Assessment studies is being developed by focusing on a model site. Pathways analysis is an important component of these studies. It involves the prediction of the rate at which radionuclides might be released from a disposal vault and travel through the geosphere and biosphere to reach man. The pathways analysis studies cover three major topics: geosphere pathways analysis, biosphere pathways analysis and potentially-disruptive-phenomena analysis. Geosphere pathways analysis includes a total systems analysis, using the computer program GARD2, vault analysis, which considers container failure and waste leaching, hydrogeological modelling and geochemical modelling. Biosphere pathways analysis incorporates a compartmental modelling approach using the computer program RAMM, and a food chain analysis using the computer program FOOD II. Potentially-disruptive-phenomena analysis involves the estimation of the probability and consequences of events such as earthquakes which might reduce the effectiveness of the barriers preventing the release of radionuclides. The current stage of development of the required methodology and data is discussed in each of the three areas and preliminary results are presented. (author)

Cyclotron for industrial production of radioisotopes: relevants characteristics

International Nuclear Information System (INIS)

Lima, Wanderley de

1997-01-01

The industrial production of radioisotopes requests cyclotrons with easy maintenance services, high productivity and low operation costs. To obtain this performance the experts on the have achieved excellent results, taking advantage of modern resources in calculation and modeling. Only by the maximum exploitation of the azimutal variation of the magnetic field, a physical concept introduced in 1967 with the isocronous cyclotrons, it was possible to construct cyclotrons with only 30% of the electrical consumption required by the former cyclotrons. On the other hand, the acceleration of negative ions enable the 100% accelerated beam utilization, without internal energy dissipation, obtaining beam intensities up to 1mA in continuous running which represents an increased factor of 15. Other construction parameters were optimized aiming at reliability and reduction in the components activation. Concerning energy consumption and the beam intensity supplied, a present cyclotron with 30 MeV and 300μA of protons current is 15 times more efficient than its precedent. (author). 6 refs., 1 fig., 2 tabs

Experimental investigation of the long term dissolution properties of a cement-based vault backfill

International Nuclear Information System (INIS)

Butcher, E.J.; Borwick, J.; Thorburn, A.A.; Williams, S.J.

2012-01-01

One concept for the long-term management of packages of intermediate-level radioactive waste (ILW) is to place them in underground vaults in a Geological Disposal Facility (GDF). After the packaged waste is placed in the vault it is planned to fill the space around the waste packages with a cement-based backfill prior to closure of the facility. The currently specified backfill is the NRVB (Nirex Reference Vault Backfill), composed of a blend of Portland cement, limestone flour and hydrated lime. Leaching trials are ongoing at the UK National Nuclear Laboratory (NNL) to investigate the dissolution of NRVB until pH values typical of calcium carbonate are achieved. The objective of this work is to determine the buffering capacity of samples of the NRVB, and to allow the sequential release of the alkalinity from the intact samples to be monitored. Leaching is being performed utilising three leachants: deionised water and two saline solutions. Trials have been performed in duplicate for each leachant to allow an initial assessment to be made of the reproducibility of the data produced. In order to simulate the conditions expected in the GDF the approach being used in the trials is a flow through experiment utilising a flexible wall permeameter, within a 35 deg temperature-controlled cell

Present situation of 'baby cyclotron'

International Nuclear Information System (INIS)

Yamada, Teruo

1981-01-01

A ''baby cyclotron'' has been developed by the Japan Steel Works, Ltd. Its No. 1 model (proton 9.4 MeV) was delivered to the Nakano Hospital of National Sanatorium in March, 1979. It is being used successfully for the production of 11 C, 13 N and 15 O and labeled compounds. The proton or deuteron particles accelerated in the cyclotron collide on target materials. The target box, which is automatically changeable, is directly installed to the accelerating box, thereby taking the safety measures for any leaking radiation. The following matters are described: the production of short-lived radioisotopes (RI yields and treatment); the processes of production in the Nakano Hospital, with No. 1 baby cyclotron, including the photosynthesis of labeled compounds such as 11 C-labeled glucose; the research on the automation in the synthesis of organic labeled compounds like 11 C-palmitic acid. (J.P.N.)

Cryogenic system for VECC K500 superconducting cyclotron

CERN Document Server

Pal, G; Bhattacharyya, T K; Bhandari, R K

2009-01-01

VEC Centre, Kolkata in India is at an advanced stage of commissioning a K500 superconducting cyclotron. The superconducting coil of the magnet for cyclotron is cooled by liquid helium. Three liquid helium cooled cryopanels, placed inside the Dees of the radiofrequency system, maintain the vacuum in the acceleration region of the superconducting cyclotron. The cryogenic system for magnet for cyclotron has been tested by cooling the coil and energizing the magnet. The cryogenic system for cryopanels has also been tested. Heater and temperature sensor were placed on the liquid helium cold head for cryopanel. The temperature of the cold head was observed to be below 20 K upto a heat load of 11.7 watt.

Effect of Plyometric Training on Handspring Vault Performance and Functional Power in Youth Female Gymnasts.

Directory of Open Access Journals (Sweden)

Emma Hall

Full Text Available This study aimed to determine the effect of plyometric training (PT when added to habitual gymnastic training (HT on handspring vault (HV performance variables. Twenty youth female competitive gymnasts (Age: 12.5 ± 1.67 y volunteered to participate and were randomly assigned to two independent groups. The experimental plyometric training group (PTG undertook a six-week plyometric program, involving two additional 45 min PT sessions a week, alongside their HT, while the control group (CG performed regular HT only. Videography was used (120 Hz in the sagittal plane to record both groups performing three HVs for both the baseline and post-intervention trials. Furthermore, participants completed a countermovement jump test (CMJ to assess the effect of PT on functional power. Through the use of Quintic biomechanics software, significant improvements (P < 0.05 were found for the PTG for run-up velocity, take-off velocity, hurdle to board distance, board contact time, table contact time and post-flight time and CMJ height. However, there were no significant improvements on pre-flight time, shoulder angle or hip angle on the vault for the PTG. The CG demonstrated no improvement for all HV measures. A sport-specific PT intervention improved handspring vault performance measures and functional power when added to the habitual training of youth female gymnasts. The additional two hours plyometric training seemingly improved the power generating capacity of movement-specific musculature, which consequently improved aspects of vaulting performance. Future research is required to examine the whether the improvements are as a consequence of the additional volume of sprinting and jumping activities, as a result of the specific PT method or a combination of these factors.

Special radiation protection aspects of medical accelerators

CERN Document Server

Silari, Marco

2001-01-01

Radiation protection aspects relevant to medical accelerators are discussed. An overview is first given of general safety requirements. Next. shielding and labyrinth design are discussed in some detail for the various types of accelerators, devoting more attention to hadron machines as they are far less conventional than electron linear accelerators. Some specific aspects related to patient protection are also addressed. Finally, induced radioactivity in accelerator components and shielding walls is briefly discussed. Three classes of machines are considered: (1) medical electron linacs for 'conventional' radiation therapy. (2) low energy cyclotrons for production of radionuclides mainly for medical diagnostics and (3) medium energy cyclotrons and synchrotrons for advanced radiation therapy with protons or light ion beams (hadron therapy). (51 refs).

Near-field thermal transient and thermomechanical stress analysis of a disposal vault in crystalline hard rock

International Nuclear Information System (INIS)

Tsui, K.K.; Tsai, A.; Lee, C.F.

1981-01-01

The Canadian Nuclear Fuel Waste Management Program currently focuses on the development of a disposal vault in crystalline hard rock at a reference depth of 1 km below the surface in a suitable pluton in the Canadian Shield. As part of Ontario Hydro's technical assistance to the Atomic Energy of Canada Limited in this program, studies are being carried out to determine the effects of radiogenic heat on the near-field behaviour of a disposal vault. This paper presents the study results obtained to date. Temperature and stress fields were computed and cross-checked by several finite element codes. A comparison between vertical and horizontal borehole emplacement concepts is made. The effects of material non-linearity (temperature dependence) and three-dimensionality on the thermomechanical response are evaluated. Case histories of thermal spalling or fracturing in rock were summarized and discussed to illustrate the possible mechanisms and processes involved in thermal fracturing. An assessment of the thermomechanical stability of the rock mass around a disposal vault under a state of high horizontal in-situ stress is also presented

Variable-Energy Cyclotron for Proton Therapy Application

CERN Document Server

Alenitsky, Yu G; Vorozhtsov, A S; Glazov, A A; Mytsyn, G V; Molokanov, A G; Onishchenko, L M

2004-01-01

The requirements to characteristics of the beams used for proton therapy are considered. The operation and proposed cyclotrons for proton therapy are briefly described. The technical decisions of creation of the cyclotron with energy variation in the range 70-230 MeV and with current up to 100 nA are estimated. Taking into account the fact, that the size and cost of the cyclotron are approximately determined by the maximum proton energy, it is realistically offered to limit the maximum proton energy to 190 MeV and to elaborate a cyclotron project with a warm winding of the magnet for acceleration of H^{-} ions. The energy of the extracted protons for each run is determined by a stripped target radius in the vacuum chamber of the accelerator, and the radiation dose field for the patient is created by the external devices using the developed techniques.

In-situ radiation measurements of the C1 and C2 waste storage tank vault

International Nuclear Information System (INIS)

Yong, L.K.; Womble, P.C.; Weems, L.D.

1996-09-01

In August of 1996, the Applied Radiation Measurements Department (ARMD) of the Waste Management and Remedial Action Division (WMRAD) at Oak Ridge National Laboratory (ORNL) was tasked with characterizing the radiation fields in the C 1 and C 2 Liquid Low Level Waste (LLLW) tank vault located at ORNL. These in-situ measurements were made to provide data for evaluating the potential radiological conditions for personnel working in or around the vault during future planned activities. This report describes the locations where measurements were made, the types of radiation detection instruments used, the methods employed, the problems encountered and resolved, and discusses the results obtained

Device for providing a leak-tight penetration for electric cables through a reactor vault roof

International Nuclear Information System (INIS)

Eyral, M.; Mahe, A.

1979-01-01

The device for providing a cable penetration through the vault roof of a liquid sodium cooled fast reactor comprises a vertical tube closed at the top end by a flange-plate. Electric cables connected to measuring and detecting instruments are passed through the flange-plate which is joined to the reactor vault roof in leak-tight manner and enclosed within a removable hood. At least one horizontal plate is mounted within the vertical tube and provided with orifices for the leak-tight passage of the cables. Cable storage reels are placed within the tube and can be locked in position or released by controlled mechanical means

Radiation exposure to workers at cyclotron facilities

International Nuclear Information System (INIS)

Ribeiro, M.S.; Sanches, M.P.; Sanchez, A.S.; Rodrigues, D.L.

2001-01-01

Radiopharmaceuticals quickly furnish the information doctors need to establish a precise diagnosis of the patient's condition, and therefore to prescribe the most effective therapy. In cancerology, F18-FDG, the most widely used PET imaging tracer, excels in the early detection of cancer tumors, even very tiny ones, which it locates and clearly distinguishes from healthy surrounding tissues. IPEN-CNEN/SP has two cyclotron accelerators used mainly for radioisotope production to be utilized in nuclear medicine for diagnosis and therapy. The first is a CV-28 cyclotron, variable energy that came into operation in 1982, which was used to produce F18-FDG and Iodine 123 up to 1998. The second, a Cyclone 30 cyclotron, 30 MeV, commenced operation in 1998 for certification purpose, and due to increase demand for radiopharmaceuticals in Brazil, started F18-FDG production in 1999. Cyclotron Laboratory will be a reference Research and Developing Center in our country and will help the Brazilian and Latin-American community. It is necessary to have an adequate database to allow regular follow up and analysis of the individual dose distributions for each group involved in the cyclotron activities. These databases are also important means to assess the effectiveness of efforts in order to maintain doses ALARA and reduce inequalities. The official individual occupational dosimetry is provided by certified Laboratory of Thermoluminescent Dosimetry at IPEN-CNEN/SP. This paper describes the occupational doses distribution in Laboratory of Cyclotrons at IPEN-CNEN/SP from January, 1998 to July, 2000 and propose improvements for the future. (author)

Ramifide resonators for cyclotrons

International Nuclear Information System (INIS)

Smirnov, Yu.V.

2000-01-01

The resonators with the conductors ramified form for cyclotrons are systematized and separated into the self-contained class - the ramified resonators for cyclotrons (Carr). The ramified resonators are compared with the quarter-wave and half-wave nonramified resonators, accomplished from the transmitting lines fragments. The CRR are classified into two types: ones with the additional structural element, switched in parallel and in series. The CRR may include several additional structural elements. The CRR calculations may be concluded by analytical methods - the method of matrix calculation or the method of telegraph equations and numerical methods - by means of the ISFEL3D, MAFIA and other programs [ru

Status Report on Cyclotron Operation

International Nuclear Information System (INIS)

Kovacs, P.; Szuecs, I.; Ander, I.; Lakatos, T.; Tarkanyi, F.

2004-01-01

Complete text of publication follows. The operation of the cyclotron in 2004 was concentrated to the usual 9 months; January, July and August were reserved for maintenance and holidays. The overall working time of the accelerator was 3554 hours, the time used for systematic maintenance was 450 hours. The breakdown periods amounted to 70 hours last year, included in it a 50 hours repair of RF control module under guarantee. The cyclotron was available for users during 3034 hours. The effectively used beam-on-target time statistics is summarized in Table 1. Developments: A new measuring site with a HPGe detector based gamma spectrometer is under installation in the basement of the Cyclotron Laboratory. A two channel pneumatic rabbit system is also under development to enable fast transport of samples between the new measuring site and two irradiation sites (the low intensity fast neutron irradiation site and the beam line used for Thin Layer Activation). (author)

Cyclotron-based neutron source for BNCT

Energy Technology Data Exchange (ETDEWEB)

Mitsumoto, T.; Yajima, S.; Tsutsui, H.; Ogasawara, T.; Fujita, K. [Sumitomo Heavy Industries, Ltd (Japan); Tanaka, H.; Sakurai, Y.; Maruhashi, A. [Kyoto University Research Reactor Institute (Japan)

2013-04-19

Kyoto University Research Reactor Institute (KURRI) and Sumitomo Heavy Industries, Ltd. (SHI) have developed a cyclotron-based neutron source for Boron Neutron Capture Therapy (BNCT). It was installed at KURRI in Osaka prefecture. The neutron source consists of a proton cyclotron named HM-30, a beam transport system and an irradiation and treatment system. In the cyclotron, H- ions are accelerated and extracted as 30 MeV proton beams of 1 mA. The proton beams is transported to the neutron production target made by a beryllium plate. Emitted neutrons are moderated by lead, iron, aluminum and calcium fluoride. The aperture diameter of neutron collimator is in the range from 100 mm to 250 mm. The peak neutron flux in the water phantom is 1.8 Multiplication-Sign 109 neutrons/cm{sup 2}/sec at 20 mm from the surface at 1 mA proton beam. The neutron source have been stably operated for 3 years with 30 kW proton beam. Various pre-clinical tests including animal tests have been done by using the cyclotron-based neutron source with {sup 10}B-p-Borono-phenylalanine. Clinical trials of malignant brain tumors will be started in this year.

The solubility of U, Np, Pu, Th and Tc in a geological disposal vault for used nuclear fuel

International Nuclear Information System (INIS)

Lemire, R.J.; Garisto, F.

1989-12-01

This document describes the solubility model used to calculate the concentrations of uranium, thorium, technetium, neptunium and plutonium in a geological disposal vault for used nuclear fuel. This model is incorporated in the vault model of SYVAC3-CC3 - the third generation of the Systems Variability Analysis Code used to assess the long-term safety of the disposal of Canada's nuclear fuel waste. The data for the solubility model and the sources for these data are also reported

324 Radiochemical engineering cells and high level vault tanks mixed waste compliance status

International Nuclear Information System (INIS)

1994-01-01

The 324 Building in the Hanford 300 Area contains Radiochemical Engineering Cells and High Level Vault tanks (the open-quotes REC/HLVclose quotes) for research and development activities involving radioactive materials. Radioactive mixed waste within this research installation, found primarily in B-Cell and three of the high level vault tanks, is subject to RCRA/DWR (open-quotes RCRAclose quotes) regulations for storage. This white paper provides a baseline RCRA compliance summary of MW management in the REC/HLV, based on best available knowledge. The REC/HLV compliance project, of which this paper is a part, is intended to achieve the highest degree of compliance practicable given the special technical difficulties of managing high activity radioactive materials, and to assure protection of human health and safety and the environment. The REC/HLV was constructed in 1965 to strict standards for the safe management of highly radioactive materials. Mixed waste in the REC/HLV consists of discarded tools and equipment, dried feed stock from nuclear waste melting experiments, contaminated particulate matter, and liquid feed stock from various experimental programs in the vault tanks. B-Cell contains most of these materials. Total radiological inventory in B-Cell is estimated at 3 MCi, about half of which is potentially open-quotes dispersibleclose quotes, that is, it is in small pieces or mobile particles. Most of the mixed waste currently in the REC/HLV was generated or introduced before mixed wastes were subjected to RCRA in 1987

Studies concerning the degradation of concrete vaults for intermediate-level radioactive waste disposal

International Nuclear Information System (INIS)

Duffo, Gustavo S.; Arva, Esteban A; Giordano, Celia M.; Lafont, Claudio J.

2007-01-01

The National Atomic Energy Commission (CNEA) is the responsible for developing a management nuclear waste disposal programme. This programme contemplates the design and construction of a facility for the final disposal of intermediate-level radioactive wastes. The proposed model is the near-surface monolithic repository similar to those in operation in El Cabril, Spain. The design of this type of repository is based on the use of multiple, independent and redundant barriers. Since the vault and cover are major components of the engineered barriers, the durability of this concrete structures is an important aspect for the facilities integrity. This work presents a laboratory and field investigation performed for the last 6 years on reinforced concrete specimens, in order to predict the service life of the intermediate level radioactive waste disposal vaults from data obtained from electrochemical techniques. On the other hand, the development of sensors that allow on-line measurements of rebar corrosion potential and corrosion current density; incoming oxygen flow that reaches the metal surface; concrete electrical resistivity and chloride concentration is shown. Those sensors, properly embedded in a new full scale vault (nowadays in construction), will allow the monitoring of the corrosion process of the steel rebars embedded in the structure. All the information obtained from the sensors will be used for the final design of the container in order to achieve a service life more or equal than the foreseen durability for this type of facilities. (author) [es

NORTICA - a new code for cyclotron analysis

International Nuclear Information System (INIS)

Gorelov, D.; Johnson, D.; Marti, F.

2001-01-01

The new package NORTICA (Numerical ORbit Tracking In Cyclotrons with Analysis) of computer codes for beam dynamics simulations is under development at NSCL. The package was started as a replacement for the code MONSTER developed in the laboratory in the past. The new codes are capable of beam dynamics simulations in both CCF (Coupled Cyclotron Facility) accelerators, the K500 and K1200 superconducting cyclotrons. The general purpose of this package is assisting in setting and tuning the cyclotrons taking into account the main field and extraction channel imperfections. The computer platform for the package is Alpha Station with UNIX operating system and X-Windows graphic interface. A multiple programming language approach was used in order to combine the reliability of the numerical algorithms developed over the long period of time in the laboratory and the friendliness of modern style user interface. This paper describes the capability and features of the codes in the present state

NORTICA—a new code for cyclotron analysis

Science.gov (United States)

Gorelov, D.; Johnson, D.; Marti, F.

2001-12-01

The new package NORTICA (Numerical ORbit Tracking In Cyclotrons with Analysis) of computer codes for beam dynamics simulations is under development at NSCL. The package was started as a replacement for the code MONSTER [1] developed in the laboratory in the past. The new codes are capable of beam dynamics simulations in both CCF (Coupled Cyclotron Facility) accelerators, the K500 and K1200 superconducting cyclotrons. The general purpose of this package is assisting in setting and tuning the cyclotrons taking into account the main field and extraction channel imperfections. The computer platform for the package is Alpha Station with UNIX operating system and X-Windows graphic interface. A multiple programming language approach was used in order to combine the reliability of the numerical algorithms developed over the long period of time in the laboratory and the friendliness of modern style user interface. This paper describes the capability and features of the codes in the present state.

GOTHIC CHURCHES IN PARIS ST GERVAIS ET ST PROTAIS IMAGE MATCHING 3D RECONSTRUCTION TO UNDERSTAND THE VAULTS SYSTEM GEOMETRY

Directory of Open Access Journals (Sweden)

M. Capone

2015-02-01

benefits and the troubles. From a methodological point of view this is our workflow: - theoretical study about geometrical configuration of rib vault systems; - 3D model based on theoretical hypothesis about geometric definition of the vaults' form; - 3D model based on image matching 3D reconstruction methods; - comparison between 3D theoretical model and 3D model based on image matching;

Intensity limits of the PSI Injector II cyclotron

Science.gov (United States)

Kolano, A.; Adelmann, A.; Barlow, R.; Baumgarten, C.

2018-03-01

We investigate limits on the current of the PSI Injector II high intensity separate-sector isochronous cyclotron, in its present configuration and after a proposed upgrade. Accelerator Driven Subcritical Reactors, neutron and neutrino experiments, and medical isotope production all benefit from increases in current, even at the ∼ 10% level: the PSI cyclotrons provide relevant experience. As space charge dominates at low beam energy, the injector is critical. Understanding space charge effects and halo formation through detailed numerical modelling gives clues on how to maximise the extracted current. Simulation of a space-charge dominated low energy high intensity (9.5 mA DC) machine, with a complex collimator set up in the central region shaping the bunch, is not trivial. We use the OPAL code, a tool for charged-particle optics calculations in large accelerator structures and beam lines, including 3D space charge. We have a precise model of the present (production) Injector II, operating at 2.2 mA current. A simple model of the proposed future (upgraded) configuration of the cyclotron is also investigated. We estimate intensity limits based on the developed models, supported by fitted scaling laws and measurements. We have been able to perform more detailed analysis of the bunch parameters and halo development than any previous study. Optimisation techniques enable better matching of the simulation set-up with Injector II parameters and measurements. We show that in the production configuration the beam current scales to the power of three with the beam size. However, at higher intensities, 4th power scaling is a better fit, setting the limit of approximately 3 mA. Currents of over 5 mA, higher than have been achieved to date, can be produced if the collimation scheme is adjusted.

Considerations, measurements and logistics associated with low-energy cyclotron decommissioning

International Nuclear Information System (INIS)

Sunderland, J. J.; Erdahl, C. E.; Bender, B. R.; Sensoy, L.; Watkins, G. L.

2012-01-01

The University of Iowa’s 20-year-old 17 MeV Scanditronix cyclotron underwent decommissioning in the summer of 2011. To satisfy local, state and federal regulations defining removal, transportation and long-term safe and environmentally secure disposal of the 22 ton activated cyclotron, a series of nuclear spectroscopic measurements were performed to characterize the nature and extent of proton and neutron activation of the 22-ton cyclotron, its associated targets, and the concrete wall that was demolished to remove the old cyclotron. Neutron activation of the concrete wall was minimal and below exempt concentrations resulting in standard landfill disposal. The cyclotron assessment revealed the expected array of short and medium-lived radionuclides. Subsequent calculations suggest that meaningful levels residual activity will have decayed virtually to background after 15 years, with the total residual activity of the entire cyclotron dropping below 37 MBq (1 mCi).

High Yield F-18 Target for KOTRON-13 Cyclotron

International Nuclear Information System (INIS)

Lee, W. K.; Song, J. Y.; Park, J. Y.; Jung, K. I.; Chae, S. K.

2009-01-01

Currently the domestic radiation market for medical diagnosis witnesses a high increase of the use of PET/CT for the purpose of cancer diagnosis, and the cases of cancer diagnosis using PET/CT increase by geometric progression every year. In case of domestic practice, full body scan is taken by using FDG medical isotope medicines mainly using F-18, but the necessity of various medical radioactive isotopes according to each medical purpose is increasing. F-18 output yield is directly proportional to energy of protons and beam current, and has correlation with heat production rate in case of target and decides the function of target in accordance with the efficiency of a cooling device. At present, in case of most F-18 target, when one irradiates beam in O-18 water of about 0.2∼5mL, one has to apply heat of over 300W, a high thermal energy per unit area is irradiated in target, which is easily damaged, and it has limitation in beam current. Currently, in case of commercial target, about 2,000W beam current is the maximum value, and in case of double-grid target developed by Korea Institute of Radiological and Medical Sciences in 2004, it was designed to stand up to about 1,000W theoretically, but in reality it can irradiate lower beam current than this because of the shortage of cooling efficiency. In general, the irradiation strength to produce radioactive isotopes given in the heat emission by target substance currently is limited to 50μA against target substance irradiated in 1.6mL. However, current KOTRON-13 cyclotron can accelerate proton beam with a high scope of strength marking 100μA thru 120μA by a continuous development. Therefore, it doesn't fully function compared with that of proton beam of KOTRON-13 cyclotron. The solution about this is to get over the problem of cooling target substance of cavity in the production system of radioactive isotopes. Especially, one has to develop the method to cool target substance, and provide higher F-18 yield than

From laboratory experiments to a geological disposal vault: calculation of used nuclear fuel dissolution rates

International Nuclear Information System (INIS)

Sunder, S.; Shoesmith, D.W.; Kolar, M.; Leneveu, D.M.

1998-01-01

Calculation of used nuclear fuel dissolution rates in a geological disposal vault requires a knowledge of the redox conditions in the vault. For redox conditions less oxidizing than those causing UO 2 oxidation to the U 3 O 7 , stage, a thermodynamically-based model is appropriate. For more oxidizing redox conditions a kinetic or an electrochemical model is needed to calculate these rates. The redox conditions in a disposal vault will be affected by the radiolysis of groundwater by the ionizing radiation associated with the fuel. Therefore, we have calculated the alpha-, beta- and gamma-dose rates in water in contact with the reference used fuel in the Canadian Nuclear Fuel Waste Management Program (CNFWMP) as a function of cooling time. Also, we have determined dissolution rates of UO 2 fuel as a function of alpha and gamma dose rates from our electrochemical measurements. These room-temperature rates are used to calculate the dissolution rates of used fuel at 100 o C, the highest temperature expected in a container in the CNFWMP, as a function of time since emplacement. It is shown that beta radiolysis of water will be the main cause of oxidation of used CANDU fuel in a failed container. The use of a kinetic or an electrochemical corrosion model, to calculate fuel dissolution rates, is required for a period of ∼1000 a following emplacement of copper containers in the geologic disposal vault envisaged in the CNFWMP. Beyond this time period a thermodynamically-based model adequately predicts the fuel dissolution rates. The results presented in this paper can be adopted to calculate used fuel dissolution rates for other used UO 2 fuels in other waste management programs. (author)

ITER pressure and thermal loads to containment HTS vault LOCA analysis. Draft final report EC Task SEA 3, Subtask 3-4

Energy Technology Data Exchange (ETDEWEB)

Blomquist, R; Shen, K; Sjoeberg, A

1995-03-01

This study has been performed within the framework of the EC Task SEA 3 and its objective is to provide necessary data in supporting the design solution of the ITER secondary confinement around the primary heat transfer system equipment. These data relate to the required dimensions for the blow-out panels, the vent lines and the suppression tank following a LOCA in one of the HTS vaults, namely the first wall/shielding blanket(FW/SB) vault, divertor vault and vacuum vessel (VV) vault. In this report, we present the design and operational input and describe the identified accident sequences. The input data are in correspondence with ITER design data of November 1994. The computer codes used are RELAP5 (LOCA flows) and CONTAIN (secondary confinement thermal-hydraulics) and models of calculations are given. The results in the form of diagrams demonstrating transients of various variables after a LOCA, are presented. After some discussions of the results, we indicate some topics for the continuing study with the emphasis on optimization of the containment system. 10 refs, 29 figs.

ITER pressure and thermal loads to containment HTS vault LOCA analysis. Draft final report EC Task SEA 3, Subtask 3-4

International Nuclear Information System (INIS)

Blomquist, R.; Shen, K.; Sjoeberg, A.

1995-03-01

This study has been performed within the framework of the EC Task SEA 3 and its objective is to provide necessary data in supporting the design solution of the ITER secondary confinement around the primary heat transfer system equipment. These data relate to the required dimensions for the blow-out panels, the vent lines and the suppression tank following a LOCA in one of the HTS vaults, namely the first wall/shielding blanket(FW/SB) vault, divertor vault and vacuum vessel (VV) vault. In this report, we present the design and operational input and describe the identified accident sequences. The input data are in correspondence with ITER design data of November 1994. The computer codes used are RELAP5 (LOCA flows) and CONTAIN (secondary confinement thermal-hydraulics) and models of calculations are given. The results in the form of diagrams demonstrating transients of various variables after a LOCA, are presented. After some discussions of the results, we indicate some topics for the continuing study with the emphasis on optimization of the containment system. 10 refs, 29 figs

The effects of vault drainage on postoperative morbidity after vaginal hysterectomy for benign gynaecological disease: a randomised controlled trial.

Science.gov (United States)

Dua, A; Galimberti, A; Subramaniam, M; Popli, G; Radley, S

2012-02-01

To evaluate the efficacy of vault drainage in reducing the immediate postoperative morbidity associated with vaginal hysterectomy carried out for benign gynaecological conditions. Randomised controlled trial. A tertiary referral gynaecology centre in UK. A total of 272 women who underwent vaginal hysterectomy for benign conditions between March 2005 and June 2010. The 272 women were randomised to have a drain inserted or not inserted, 'drain' or 'no drain', respectively, before vault closure during vaginal hysterectomy, using a sealed envelope technique. The surgical procedures were performed using the surgeons' standard technique and postoperative care was delivered according to the unit's protocol. The primary outcome measure was reduction in postoperative febrile morbidity. Secondary outcome measures were hospital readmission rate, blood transfusion, change in postoperative haemoglobin and length of stay. In all, 135 women were randomised to have a drain and 137 to 'no drain'. There were no differences in the incidence of febrile morbidity, length of stay, change in haemoglobin or need for postoperative blood transfusion between the two groups. The routine use of vault drain at vaginal hysterectomy for benign disorders has no significant effect on postoperative morbidity. The use of vault drain in this context is not recommended. © 2011 The Authors BJOG An International Journal of Obstetrics and Gynaecology © 2011 RCOG.

An experimental study on cyclotron-Cherenkov radiation

Energy Technology Data Exchange (ETDEWEB)

Lee, C Y; Masuzaki, M; Yoshida, H; Toyosugi, N; Kamada, K; Ando, R [Kanazawa Univ. (Japan). Department of Physics

1997-12-31

Dielectric-loaded cylindrical waveguide configurations with an injected electron beam in which the growth rate of the cyclotron-Cherenkov instability surpasses that of the Cherenkov instability were sought by numerical treatment, and one configuration of this kind was found. This configuration consists of a metallic core and an outer metallic cylinder with a dielectric liner on the inner surface. Based on the calculations, an experimental device was designed and assembled to investigate experimentally radiation due to the cyclotron-Cherenkov instability. Beam propagation in the dielectric-loaded coaxial waveguide and microwave radiation due to the cyclotron-Cherenkov instability and the Cherenkov instability were studied. (author). 6 figs., 10 refs.

The booster linac of the Sparkle Company 18 MeV Cyclotron: main design elements

International Nuclear Information System (INIS)

Picardi, L.; Ronsivalle, C.

2009-01-01

The Sparkle Company (Casarano, Le) that is setting up a centre for production and research on radioisotopes for medical use, has requested to the ENEA Accelerator Laboratory a specific design of a linear accelerator for boosting the energy of its commercial cyclotron from 18 to 24 MeV, with the aim of implementing a small proton irradiation facility for radiobiology studies. This is the first case of coupling a cyclotron beam to a linac, that, if successful, can give rise to a new class of accelerators for proton therapy. The linac can accelerate only a very small portion of the cyclotron beam, due to the intrinsic mismatching of the two kind of accelerators both in the vertical and in the longitudinal phase planes. A beam transport line has been studied that besides matching at best the beam to the linac in the transverse plane, is equipped with a chopping system to lower drastically the primary beam power in order to protect the linac structure. The linac is SCDTL type, and operates at 3 GHz. In the following the results of the design are presented. [it

Cyclotron Development and Technical Aspects on Accelerator Based Laboratory Development

International Nuclear Information System (INIS)

Sunarhadijoso

2000-01-01

BATAN is planning to establish an accelerator-based laboratory at P3TM Yogyakarta as an effort in the development and use of accelerator technology for improving industrial performance and public welfare. This paper reviews several aspects of cyclotron technology and describes the combination of a linear accelerator - cyclotron system as an alternative to be considered in the planing of the laboratory. The progress of cyclotron technology is discussed covering three generations, i.e. conventional cyclotron, synchrocyclotron and AVF cyclotron generations. The planning should not consider the accelerator application for radioisotope production because it is established in Serpong with the existing negative ion cyclotron. The proposed facility at P3TM may comprise two linear accelerators coupled with a positive ion cyclotron of synchrocyclotron generation. In fact, the attachment of the synchrocyclotron unit is flexible and it can be installed subsequently if the higher energy particle beam, which can not be produced by the linear accelerators, is extremely needed. Some technical aspects related to ion beam application, building construction and infrastructure, human resources, and specification of function test are discussed for additional information in the implementation of the planning. (author)

Cyclotrons in developing countries

International Nuclear Information System (INIS)

Vera Ruiz, Hernan

2004-01-01

Cyclotron accelerators are prolific sources of charged particle for the production of radionuclides and have become an essential tool in the practice of modern nuclear medicine by providing reliable radiotracers for SPECT and PET studies. In a recent survey conducted by the IAEA in 2001, the growth in the number of cyclotron facilities installed in laboratories and hospitals in developed as well as developing countries was recorded. This trend, which started in the late 70's, continues in the present time also and all indications are that it will continue in the next five to ten years. The reasons for this growth are several: technology involved has become more user or 'hospital friendly', third party reimbursement for several clinical studies based on F-18 PET radiopharmaceuticals at least in some of the advanced countries started in 1998 and above all, the clear irrefutable and demonstrable conclusion of the positive cost/benefit outcomes of PET studies in the field of oncology to a lesser degree, thus far, for cardiology and neurology. It is however recognizable that the overall financial cost of the technology, which comprises the premises to house the facility, the cyclotron accelerator, the corresponding radiochemistry and quality control equipment and the PET cameras can be nevertheless an expensive proposition that requires careful advance planning. This fact is even more relevant when the facility is planned for installation in a developing country, which, frequently, in addition to having a lack of sufficient financial resources, do have shortage of qualified human resources to efficiently run the facility. In spite of the above, it is fact that more and more public as well as private organizations in the developing countries are setting up cyclotron/PET programmes or are seriously considering the installation of such a facility

Suppression of cyclotron instability in Electron Cyclotron Resonance ion sources by two-frequency heating

International Nuclear Information System (INIS)

Skalyga, V.; Izotov, I.; Mansfeld, D.; Kalvas, T.; Koivisto, H.; Komppula, J.; Kronholm, R.; Laulainen, J.; Tarvainen, O.

2015-01-01

Multiple frequency heating is one of the most effective techniques to improve the performance of Electron Cyclotron Resonance (ECR) ion sources. The method increases the beam current and average charge state of the extracted ions and enhances the temporal stability of the ion beams. It is demonstrated in this paper that the stabilizing effect of two-frequency heating is connected with the suppression of electron cyclotron instability. Experimental data show that the interaction between the secondary microwave radiation and the hot electron component of ECR ion source plasmas plays a crucial role in mitigation of the instabilities

Initial operation of the cyclotron CYTRACK

International Nuclear Information System (INIS)

Denisov, Yu.N.; Dolya, S.N.; Kalinichenko, V.V.; Karamysheva, G.A.; Kostromin, S.A.; Fedorenko, S.B.

2005-01-01

The industrial cyclotron CYTRACK is dedicated to produce the track membranes. It is the basic instrument for the industry of membrane products to be consumed in medicine, biotechnology, pharmacology, microelectronics and many other industries. Cyclotron CYTRACK started working in August 2002. Argon ions were accelerated to the project energy - 2.4 MeV/nucleon, the extracted beam intensity was about 200 nA, the extraction efficiency totaled ∼50%

Radiological Assessment for the Vance Road Facility Source Vault, Oak Ridge Institute for Science and Education, Oak Ridge, Tennessee

International Nuclear Information System (INIS)

Morton, J. R.

2000-01-01

From the 1950s, the Vance Road laboratories had been used for a broad range of nuclear medicine research involving numerous radionuclides. These radionuclides were stored in the a source vault located on the first floor of the facility. The Environmental Survey and Site Assessment Program (ESSAP) of ORISE performed a radiological assessment survey of the source vault after it had been remediated and in preparation for converting the area to office space

Microbially influenced corrosion of copper nuclear fuel waste containers in a Canadian disposal vault

Energy Technology Data Exchange (ETDEWEB)

King, F

1996-11-01

An assessment of the potential for microbially influenced corrosion (MIC) of copper nuclear fuel waste containers in a Canadian disposal vault is presented. The assessment is based on a consideration of the microbial activity within a disposal vault, the reported cases of MIC of Cu alloys in the literature and the known corrosion behaviour of Cu. Because of the critical role of biofilms in the reported cases of MIC, their formation and properties are discussed in detail. Next, the literature on the MIC of Cu alloys is briefly reviewed. The various MIC mechanisms proposed are critically discussed and the implications for the corrosion of Cu containers considered. In the majority of literature cases, MIC depends on alternating aerated and deaerated environments, with accelerated corrosion being observed when fresh aerated water replaces stagnant water, e.g., the MIC of Cu-Ni heat exchangers in polluted seawater and the microbially influenced pitting of Cu water pipes. Finally, because of the predominance of corrosion by sulphate-reducing bacteria (SRB) in the MIC literature, the abiotic behaviour of Cu alloys in sulphide solutions is also reviewed. The effect of the evolving environment in a disposal vault on the extent and location of microbial activity is discussed. Biofilm formation on the container surface is considered unlikely throughout the container lifetime, but especially initially when the environmental conditions will be particularly aggressive. Microbial activity in areas of the vault away from the container is possible, however. Corrosion of the container could then occur if microbial metabolic by-products diffuse to the container surface. Sulphide, produced by the action of SRB are considered to be the most likely cause of container corrosion. It is concluded that the only likely form of MIC of Cu containers will result from sulphide produced by SRB diffusing to the container surface. A modelling procedure for predicting the extent of corrosion is

Microbially influenced corrosion of copper nuclear fuel waste containers in a Canadian disposal vault

International Nuclear Information System (INIS)

King, F.

1996-11-01

An assessment of the potential for microbially influenced corrosion (MIC) of copper nuclear fuel waste containers in a Canadian disposal vault is presented. The assessment is based on a consideration of the microbial activity within a disposal vault, the reported cases of MIC of Cu alloys in the literature and the known corrosion behaviour of Cu. Because of the critical role of biofilms in the reported cases of MIC, their formation and properties are discussed in detail. Next, the literature on the MIC of Cu alloys is briefly reviewed. The various MIC mechanisms proposed are critically discussed and the implications for the corrosion of Cu containers considered. In the majority of literature cases, MIC depends on alternating aerated and deaerated environments, with accelerated corrosion being observed when fresh aerated water replaces stagnant water, e.g., the MIC of Cu-Ni heat exchangers in polluted seawater and the microbially influenced pitting of Cu water pipes. Finally, because of the predominance of corrosion by sulphate-reducing bacteria (SRB) in the MIC literature, the abiotic behaviour of Cu alloys in sulphide solutions is also reviewed. The effect of the evolving environment in a disposal vault on the extent and location of microbial activity is discussed. Biofilm formation on the container surface is considered unlikely throughout the container lifetime, but especially initially when the environmental conditions will be particularly aggressive. Microbial activity in areas of the vault away from the container is possible, however. Corrosion of the container could then occur if microbial metabolic by-products diffuse to the container surface. Sulphide, produced by the action of SRB are considered to be the most likely cause of container corrosion. It is concluded that the only likely form of MIC of Cu containers will result from sulphide produced by SRB diffusing to the container surface. A modelling procedure for predicting the extent of corrosion is

An automated magnetic tape vault at CERN computer center

CERN Multimedia

Claudia Marcelloni

2008-01-01

The rapidly changing data processing landscape the underlying long-term storage technology remains the tried and tested magnetic tape. This robust and mature technology is used to store the complete LHC data set, from which a fraction of the data is copied to overlying disk caches for fast and widespread access. The handling of the magnetic tape cartridges is now fully automated, as they are racked in vaults where they are moved between the storage shelves and the tape drives by robotic arms.

Electron cyclotron emission measurements during 28 GHz electron cyclotron resonance heating in Wendelstein WVII-A stellarator

International Nuclear Information System (INIS)

Hartfuss, H.J.; Gasparino, U.; Tutter, M.; Brakel, R.; Cattanei, G.; Dorst, D.; Elsner, A.; Engelhardt, K.; Erckmann, V.; Grieger, G.; Grigull, P.; Hacker, H.; Jaeckel, H.; Jaenicke, R.; Junker, J.; Kick, M.; Kroiss, H.; Kuehner, G.; Maassberg, H.; Mahn, C.; Mueller, G.; Ohlendorf, W.; Rau, F.; Renner, H.; Ringler, H.; Sardei, F.; Weller, A.; Wobig, H.; Wuersching, E.; Zippe, M.; Kasparek, W.; Mueller, G.A.; Raeuchle, E.; Schueller, P.G.; Schwoerer, K.; Thumm, M.

1987-11-01

Electron cyclotron emission measurements have been carried out on electron cyclotron resonance heated plasmas in the WENDELSTEIN VII-A Stellarator. Blackbody radiation from the thermalized plasma main body as well as radiation from a small amount of weakly relativistic suprathermal electrons has been detected. In addition sideband emission has been observed near the second harmonic of the heating line source. Harmonic generation and parametric wave decay at the upper hybrid layer may be a reasonable explanation. (orig.)

EVALUATION OF SULFATE ATTACK ON SALTSTONE VAULT CONCRETE AND SALTSTONESIMCO TECHNOLOGIES, INC. PART1 FINAL REPORT

International Nuclear Information System (INIS)

Langton, C.

2008-01-01

This report summarizes the preliminary results of a durability analysis performed by SIMCO Technologies Inc. to assess the effects of contacting saltstone Vaults 1/4 and Disposal Unit 2 concretes with highly alkaline solutions containing high concentrations of dissolved sulfate. The STADIUM(reg s ign) code and data from two surrogate concretes which are similar to the Vaults 1/4 and Disposal Unit 2 concretes were used in the preliminary durability analysis. Simulation results for these surrogate concrete mixes are provided in this report. The STADIUM(reg s ign) code will be re-run using transport properties measured for the SRS Vaults 1/4 and Disposal Unit 2 concrete samples after SIMCO personnel complete characterization testing on samples of these materials. Simulation results which utilize properties measured for samples of Vaults 1/4 and Disposal Unit 2 concretes will be provided in Revision 1 of this report after property data become available. The modeling performed to date provided the following information on two concrete mixes that will be used to support the Saltstone PA: (1) Relationship between the rate of advancement of the sulfate front (depth of sulfate ion penetration into the concrete) and the rate of change of the concrete permeability and diffusivity. (2) Relationship between the sulfate ion concentration in the corrosive leachate and the rate of the sulfate front progression. (3) Equation describing the change in hydraulic properties (hydraulic conductivity and diffusivity) as a function of sulfate ion concentration in the corrosive leachate. These results have been incorporated into the current Saltstone PA analysis by G. Flach (Flach, 2008). In addition, samples of the Saltstone Vaults 1/4 and Disposal Unit 2 concretes have been prepared by SIMCO Technologies, Inc. Transport and physical properties for these materials are currently being measured and sulfate exposure testing to three high alkaline, high sulfate leachates provided by SRNL is

Addendum to the composite analysis for the E-Area Vaults and Saltstone Disposal Facilities

Energy Technology Data Exchange (ETDEWEB)

Cook, J.R.

2000-03-13

This report documents the composite analysis performed on the two active SRS low-level radioactive waste disposal facilities. The facilities are the Z-Area Saltstone Disposal Facility and the E-Area Vaults Disposal Facility.

Addendum to the composite analysis for the E-Area Vaults and Saltstone Disposal Facilities

International Nuclear Information System (INIS)

Cook, J.R.

2000-01-01

This report documents the composite analysis performed on the two active SRS low-level radioactive waste disposal facilities. The facilities are the Z-Area Saltstone Disposal Facility and the E-Area Vaults Disposal Facility

[Cyclotron based nuclear science

International Nuclear Information System (INIS)

1989-06-01

This report contains papers on the following topics: Heavy ion reactors, nuclear structure and fundamental interactions; atomic and materials studies; nuclear theory; and superconducting cyclotron and instrumentation

A small low energy cyclotron for radioisotope measurements

International Nuclear Information System (INIS)

Bertsche, K.J.

1989-11-01

Direct detection of 14 C by accelerator mass spectrometry has proved to be a much more sensitive method for radiocarbon dating than the decay counting method invented earlier by Libby. A small cyclotron (the ''cyclotrino'') was proposed for direct detection of radiocarbon in 1980. This combined the suppression of background through the use of negative ions, which had been used effectively in tandem accelerators, with the high intrinsic mass resolution of a cyclotron. Development of a small electrostatically-focused cyclotron for use as a mass spectrometer was previously reported but the sensitivity needed for detection of 14 C at natural abundance was not achieved. The major contributions of this work are the integration of a high current external ion source with a small flat-field, electrostatically-focused cyclotron to comprise a system capable of measuring 14 C at natural levels, and the analysis of ion motion in such a cyclotron, including a detailed analysis of phase bunching and its effect on mass resolution. A high current cesium sputter negative ion source generates a beam of carbon ions which is pre-separated with a Wien filter and is transported to the cyclotron via a series of electrostatic lenses. Beam is injected radially into the cyclotron using electrostatic deflectors and an electrostatic mirror. Axial focusing is entirely electrostatic. A microchannel plate detector is used with a phase-grated output. In its present form the system is capable of improving the sensitivity of detecting 14 C in some biomedical experiments by a factor of 10 4 . Modifications are discussed which could bring about an additional factor of 100 in sensitivity, which is important for archaeological and geological applications. Possibilities for measurements of other isotopes, such as 3 H, and 10 Be, and 26 Al, are discussed. 70 refs

Cranial vault trauma and selective mortality in medieval to early modern Denmark

DEFF Research Database (Denmark)

Boldsen, Jesper L; Milner, George R; Weise, Svenja

2015-01-01

to interpersonal violence in past populations. Three medieval to early modern Danish skeletal samples are used to estimate the effect of selective mortality on males with cranial vault injuries who survived long enough for bones to heal. The risk of dying for these men was 6.2 times higher than...

U-2g0 cyclotron operational experience and improvement

International Nuclear Information System (INIS)

Gigal, B.N.; Gul'bekyan, G.G.; Kozlov, S.I.; Oganesyan, R.Ts.

1983-01-01

Brief description of main syste's of the U-200 isochronous 2-m cyclotron put into opera ion in 1968 is given and its operational characteristics a e presented. The cyclotron is used for conducting inve tigations in the field of nuclear physics. Ions from d uterium to argon have been accelerated in the cyclotro'. Annual time of target irradiation constitutes 2000-4000. The specific features of the cyclotron are: high l vel of a magnetic field (of about 20 kOe), possibili y of acceleration of ions with different mass-to-charge ratio a low correcting winding power, simple and high-e fective beam extraction by the method of charge exchange on a thin target allowing to vary smoothly energy of extracted ons. An experience in the U-200 cyclotron development and o eration is used as the basis for designing and choosing basic parameters of the U-200P, U-250, U-400 heavy ion cyclotrons

Electron-Cyclotron Waves

NARCIS (Netherlands)

Westerhof, E.

1994-01-01

The essential elements of the theory of electron cyclotron waves are reviewed, The two main electro-magnetic modes of propagation are identified and their dispersion and absorption properties are discussed. The importance of the use of the relativistic resonance condition is stressed.

Improving the Aesthetic Outcome in Scaphocephaly Correction: Hairline Lowering During Vault Remodeling Procedures.

Science.gov (United States)

Wittig, Joern; Duncan, Christian

2017-06-01

The bossed forehead in patients with scaphocephaly often leads to a high hairline. A new technique to improve the aesthetic outcome of patients undergoing scaphocephaly correction is described. Sixteen patients with scaphocephaly and having a high hairline due to frontal bossing who underwent scaphocephaly correction by subtotal or total vault remodeling were analyzed. The median age at surgery was 18 months. The mean distance between the nasofrontal suture and the hairline was preoperatively 70 mm (range 58-91). An obvious lowering of the hairline could be achieved in all 16 patients. The mean postoperative distance nasofrontal suture to hairline was 59 mm (range 50-73). There were no complications associated with the technique. The hairline lowering technique is a useful addition to vault remodeling techniques and can improve the postoperative aesthetic appearance considerably. The authors recommend this technique in scaphocephaly patients, who present with a high hairline.

Adding EUNIS and VAULT rocket data to the VSO with Modern Perl frameworks

Science.gov (United States)

Mansky, Edmund

2017-08-01

A new Perl code is described, that uses the modern Object-oriented Moose framework, to add EUNIS and VAULT rocket data to the Virtual Solar Observatory website. The code permits the easy fixing of FITS header fields in the case where some FITS fields that are required are missing from the original data files. The code makes novel use of the Moose extensions “before” and “after” to build in dependencies so that database creation of tables occurs before the loading of data, and that the validation of file-dependent tables occurs after the loading is completed. Also described is the computation and loading of the deferred FITS field CHECKSUM into the database following the loading and validation of the file-dependent tables. The loading of the EUNIS 2006 and 2007 flight data, and the VAULT 2.0 flight data is described in detail as illustrative examples.

Lower-hybrid absorption at the ion cyclotron harmonics

International Nuclear Information System (INIS)

Puri, S.

1975-01-01

In the presence of magnetic field gradients, the lower-hybrid wave can be absorbed through linear collisionless damping at the location of cyclotron or cyclotron harmonic resonances acting as singular turning points in the path of the advancing wave-front. (Auth.)

Influence of the program of prophylaxis of violations of vaults of foot on physical preparedness of children of midchildhood

Directory of Open Access Journals (Sweden)

Valkevich A.V.

2012-06-01

Full Text Available Purpose of work - to probe influence of the program of prophylaxis of violations of vaults of foot on physical preparedness of children of midchildhood. 40 children which studied in a tourist class took part in experiment. All of children on the state a health were attributed to the basic group. In the process of testing determined the indexes of speed (run 30 meters, flexibility (forerake from position «sitting», adroitness (shuttle run 4x9 meters, speed-power qualities (broad jump from a place, force (undercutting on a low cross-beam and endurance (run, meters. The substantive provisions of the program of prophylaxis of violations of vaults of foot are reflected for children. Certain and analysed dynamics of indexes of physical preparedness of schoolboys on completion of the program of prophylaxis of violations of vaults of foot in educational process.

Stability and nonlinear dynamics of gyrotrons at cyclotron harmonics

International Nuclear Information System (INIS)

Saraph, G.P.; Nusinovich, G.S.; Antonsen, T.M. Jr.; Levush, B.

1992-01-01

Gyrotrons operating at higher harmonics of the cyclotron frequency can overcome the frequency limitations caused by achievable strength of the magnetic field. However, the excitation of modes at the fundamental frequency exhibit a major problem for stable operation of harmonic gyrotron at high power with high efficiency. Therefore the issues of stability of gyrotron operation at the cyclotron harmonics and nonlinear dynamics of mode interaction are of great importance. The results of the authors stability analysis and multimode simulation are presented here. A detailed nonlinear theory of steady state single mode operation at cyclotron harmonics has been presented previously, taking into account beam-wave coupling and nonlinear gain function at cyclotron harmonics. A set of equations describing low gain regime interaction of modes resonant at different cyclotron harmonics was studied before. The multifrequency time-dependent nonlinear analysis presented here is based on previous gyrotron studies and beam-wave interaction at cyclotron harmonics. The authors have determined the parameter space for stable single mode operation at the second harmonic. The nonlinear dynamics of mode evolution and mode interaction for a harmonic gyrotron is presented. A new nonlinear effect in which the parasite at the fundamental harmonic helps excite the operating mode at the second harmonic has been demonstrated

A mobile superconducting cyclotron for PET and neutron radiography

International Nuclear Information System (INIS)

Griffiths, R.

1988-01-01

The report addresses the development of a mobile superconducting cyclotron for PET (positron emission tomography) and neutron radiography. Proposals for an ultralight cyclotron were made by Finlan et al., who suggested a novel technique of utilising a superconducting magnet with RF acceleration and iron sectors contained within the room temperature bore of the magnet. Detailed design of a cyclotron based on this concept has progressed well at Oxford Instruments. The main design priorities were to minimise the weight and power consumption of the cyclotron. The cyclotron required a large amount of shielding to reduce either radiation background levels or stray magnetic field. Thus low background levels of radiation and magnetic field are key design criteria. The superconducting magnet has a mean field of 2.35 Tesla and a room temperature bore diameter of 500 mm. Three pairs of profiled iron sectors placed in the center of the warm bore of the magnet provide an azimuthally varying magnetic field. This permits the use of high beam currents with low background. A novel technique is incorporated to reduce the stray magnetic field and radiation from the cyclotron. The RF system consists of three pairs of resonators mounted within the warm bore of the magnet between the iron sectors. (Nogami, K.)

Fabrication of beam diagnostic components for Superconducting Cyclotron at Kolkata

International Nuclear Information System (INIS)

Roy, S.; Bhattacharya, S.; Das, T.; Bhattacharyya, T.K.; Pal, S.; Pal, G.; Mallik, C.; Bhandari, R.K.

2009-01-01

The viewer probe and main probe are used for determining the position and current of charged particles as it is accelerated inside the superconducting cyclotron. The viewer probe is used to visually observe the shape of the charged particle beam inside the cyclotron with the help of a borescope. The main probe measures the distribution of charged particles. The viewer probe and main probe are bellow sealed. They can be positioned with an accuracy of 0.5 mm at different radii within the superconducting cyclotron. M9 slit is placed after the exit flange of the cyclotron. It determines the position of the beam leaving the cyclotron. The beam line has slits, faraday cup, beam viewers, collimators, etc. for beam diagnostics. This paper presents the mechanical design and details of beam diagnostic components. (author)

CSER 94-014: Storage of metal-fuel loaded EBR-II casks in concrete vault on PFP grounds

International Nuclear Information System (INIS)

Hess, A.L.

1994-01-01

A criticality safety evaluation is presented to permit EBR-2 spent fuel casks loaded with metallic fuel rods to be stored in an 8-ft diameter, cylindrical concrete vault inside the PFP security perimeter. The specific transfer of three casks with Pu alloy fuel from the Los Alamos Molten Plutonium Reactor Experiment from the burial grounds to the vault is thus covered. Up to seven casks may be emplaced in the casing with 30 inches center to center spacing. Criticality safety is assured by definitive packaging rules which keep the fissile medium dry and at a low effective volumetric density

Radiological performance assessment for the E-Area Vaults Disposal Facility

International Nuclear Information System (INIS)

Cook, J.R.

1994-01-01

These document contains appendices A-M for the performance assessment. They are A: details of models and assumptions, B: computer codes, C: data tabulation, D: geochemical interactions, E: hydrogeology of the Savannah River Site, F: software QA plans, G: completeness review guide, H: performance assessment peer review panel recommendations, I: suspect soil performance analysis, J: sensitivity/uncertainty analysis, K: vault degradation study, L: description of naval reactor waste disposal, M: porflow input file

MC-50 AVF cyclotron operation

Energy Technology Data Exchange (ETDEWEB)

Chae, Jong Seo; Lee, Dong Hoon; Kim, You Seok; Park, Chan Won; Lee, Yong Min; Hong, Sung Seok; Lee, Min Yong

1995-12-01

The first cyclotron in Korea, MC-59 cyclotron is used for neutron irradiation, radionuclide development, production and material and biomedical research. 50.5MeV and 35MeV proton beam have been extracted with 20-70 .mu.A. A total of beam extraction time are 1095.7 hours. 206.5 hours are used for the developments and 663.8 hours are for radionuclide production and development and 225.4 hours for application researches. The shutdown days are 23days. Fundamental data for failure decrement and efficient beam extraction were composed and maintenance technologies were developed. (author). 8 tabs., 17 figs., 10 refs.

MC-50 AVF cyclotron operation

International Nuclear Information System (INIS)

Kim, Yu Seok; Chai, Jong Seo; Bak, Seong Ki; Park, Chan Won; Jo, Young Ho; Hong, Seong Seok; Lee, Min Yong; Jang Ho Ha

2000-01-01

The first cyclotron in Korea, MC-50 cyclotron is used for neutron irradiation, radionuclide development, production and material and biomedical research. 50.5MeV and 35MeV proton beam have been extracted with 20-60μA. A total of beam extraction time are 1095.7 hours. 206.5 hours are used for the developments and 663.8 hours are for radionuclide production and development and 225.4 hours for application researches. The shutdown days are 23 days. Fundamental data for failure decrement and efficient beam extraction were composed and maintenance technologies were developed

MC-50 AVF cyclotron operation

Energy Technology Data Exchange (ETDEWEB)

Kim, Yu Seok; Chai, Jong Seo; Bak, Seong Ki; Park, Chan Won; Jo, Young Ho; Hong, Seong Seok; Lee, Min Yong; Jang Ho Ha

2000-01-01

The first cyclotron in Korea, MC-50 cyclotron is used for neutron irradiation, radionuclide development, production and material and biomedical research. 50.5MeV and 35MeV proton beam have been extracted with 20-60{mu}A. A total of beam extraction time are 1095.7 hours. 206.5 hours are used for the developments and 663.8 hours are for radionuclide production and development and 225.4 hours for application researches. The shutdown days are 23 days. Fundamental data for failure decrement and efficient beam extraction were composed and maintenance technologies were developed.

MC-50 AVF cyclotron operation

International Nuclear Information System (INIS)

Chae, Jong Seo; Lee, Dong Hoon; Kim, You Seok; Park, Chan Won; Lee, Yong Min; Hong, Sung Seok; Lee, Min Yong.

1995-12-01

The first cyclotron in Korea, MC-59 cyclotron is used for neutron irradiation, radionuclide development, production and material and biomedical research. 50.5MeV and 35MeV proton beam have been extracted with 20-70 .mu.A. A total of beam extraction time are 1095.7 hours. 206.5 hours are used for the developments and 663.8 hours are for radionuclide production and development and 225.4 hours for application researches. The shutdown days are 23days. Fundamental data for failure decrement and efficient beam extraction were composed and maintenance technologies were developed. (author). 8 tabs., 17 figs., 10 refs

Building 211 cyclotron characterization survey report

Energy Technology Data Exchange (ETDEWEB)

NONE

1998-03-30

The Building 211 Cyclotron Characterization Survey includes an assessment of the radioactive and chemical inventory of materials stored within the facility; an evaluation of the relative distribution of accelerator-produced activation products within various cyclotron components and adjacent structures; measurement of the radiation fields throughout the facility; measurement and assessment of internal and external radioactive surface contamination on various equipment, facility structures, and air-handling systems; and an assessment of lead (Pb) paint and asbestos hazards within the facility.

Cyclotron beam dynamic simulations in MATLAB

International Nuclear Information System (INIS)

Karamysheva, G.A.; Karamyshev, O.V.; Lepkina, O.E.

2008-01-01

MATLAB is useful for beam dynamic simulations in cyclotrons. Programming in an easy-to-use environment permits creation of models in a short space of time. Advanced graphical tools of MATLAB give good visualization features to created models. The beam dynamic modeling results with an example of two different cyclotron designs are presented. Programming with MATLAB opens wide possibilities of the development of the complex program, able to perform complete block of calculations for the design of the accelerators

324 Building radiochemical engineering cells, high-level vault, low-level vault, and associated areas closure plan

International Nuclear Information System (INIS)

Barnett, J.M.

1998-01-01

The Hanford Site, located adjacent to and north of Richland, Washington, is operated by the US Department of Energy, Richland Operations Office (RL). The 324 Building is located in the 300 Area of the Hanford Site. The 324 Building was constructed in the 1960s to support materials and chemical process research and development activities ranging from laboratory/bench-scale studies to full engineering-scale pilot plant demonstrations. In the mid-1990s, it was determined that dangerous waste and waste residues were being stored for greater than 90 days in the 324 Building Radiochemical Engineering Cells (REC) and in the High-Level Vault/Low-Level Vault (HLV/LLV) tanks. [These areas are not Resource Conservation and Recovery Act of 1976 (RCRA) permitted portions of the 324 Building.] Through the Hanford Federal Facility Agreement and Consent Order (Tri-Party Agreement) Milestone M-89, agreement was reached to close the nonpermitted RCRA unit in the 324 Building. This closure plan, managed under TPA Milestone M-20-55, addresses the identified building areas targeted by the Tri-Party Agreement and provides commitments to achieve the highest degree of compliance practicable, given the special technical difficulties of managing mixed waste that contains high-activity radioactive materials, and the physical limitations of working remotely in the areas within the subject closure unit. This closure plan is divided into nine chapters. Chapter 1.0 provides the introduction, historical perspective, 324 Building history and current mission, and the regulatory basis and strategy for managing the closure unit. Chapters 2.0, 3.0, 4.0, and 5.0 discuss the detailed facility description, process information, waste characteristics, and groundwater monitoring respectively. Chapter 6.0 deals with the closure strategy and performance standard, including the closure activities for the B-Cell, D-Cell, HLV, LLV; piping and miscellaneous associated building areas. Chapter 7.0 addresses the

Continental glaciation and its potential impact on a used-fuel disposal vault in the Canadian Shield

Energy Technology Data Exchange (ETDEWEB)

Ates, Y.; Bruneau, D.; Ridgway, W.R

1997-09-01

AECL has been assessing the concept of nuclear fuel waste disposal in a vault excavated at a depth ranging between 500 m and 1000 m in a plutonic rock mass of the Canadian Shield. Glaciation is a natural process that has occurred in the past, and is likely to occur in the future, thus causing changes in the loading conditions on the rock mass hosting the disposal vault. Because the rock mass is a natural barrier to the migration of radionuclides, it is important to evaluate its integrity under load changes caused by the glaciation process. Assuming that the magnitude and extent of the future glaciation will be similar to those of the past, we have reviewed published data pertaining to the last continental ice sheet that covered a large area of North America. Estimates have been madefor the magnitude of stresses due to ice sheet loading for a vault located at depths of 500 to 1000 m. These analyses have shown that the uniform loading of a continental ice sheet would reduce the deviatoric stresses in the Canadian Shield, creating more favourable conditions than those existing at the present time, namely, high horizontal stresses. The effects of surface erosion and increase in the in-situ shear stresses have also been examined. Based on the existing data and structural modelling studies, there would be no significant structural effect on a disposal vault located at 1000-m depth in a plutonic rock. At its maximum size, an ice sheet comparable to the Laurentide ice sheet could reactivate the faults and fracture zones along the perimeter areas. Our analyses have been based on fully drained conditions only. At a potential disposal site, it would be important also to consider the potential for excess pore pressure in the analyses. (author)

Continental glaciation and its potential impact on a used-fuel disposal vault in the Canadian Shield

International Nuclear Information System (INIS)

Ates, Y.; Bruneau, D.; Ridgway, W.R.

1997-09-01

AECL has been assessing the concept of nuclear fuel waste disposal in a vault excavated at a depth ranging between 500 m and 1000 m in a plutonic rock mass of the Canadian Shield. Glaciation is a natural process that has occurred in the past, and is likely to occur in the future, thus causing changes in the loading conditions on the rock mass hosting the disposal vault. Because the rock mass is a natural barrier to the migration of radionuclides, it is important to evaluate its integrity under load changes caused by the glaciation process. Assuming that the magnitude and extent of the future glaciation will be similar to those of the past, we have reviewed published data pertaining to the last continental ice sheet that covered a large area of North America. Estimates have been made for the magnitude of stresses due to ice sheet loading for a vault located at depths of 500 to 1000 m. These analyses have shown that the uniform loading of a continental ice sheet would reduce the deviatoric stresses in the Canadian Shield, creating more favourable conditions than those existing at the present time, namely, high horizontal stresses. The effects of surface erosion and increase in the in-situ shear stresses have also been examined. Based on the existing data and structural modelling studies, there would be no significant structural effect on a disposal vault located at 1000-m depth in a plutonic rock. At its maximum size, an ice sheet comparable to the Laurentide ice sheet could reactivate the faults and fracture zones along the perimeter areas. Our analyses have been based on fully drained conditions only. At a potential disposal site, it would be important also to consider the potential for excess pore pressure in the analyses. (author)

Studies of electron cyclotron emission on text

International Nuclear Information System (INIS)

Gandy, R.F.

1990-07-01

The Auburn University electron cyclotron emission (ECE) system has made many significant contributions to the TEXT experimental program during the past five years. Contributions include electron temperature information used in the following areas of study: electron cyclotron heating (ECH), pellet injection, and impurity/energy transport. Details of the role which the Auburn ECE system has played will now be discussed

Cyclotrons for the production of radioactive beams

International Nuclear Information System (INIS)

Clark, D.J.

1990-01-01

This paper describes the characteristics and design choices for modern cyclotrons. Cyclotrons can be used in 3 areas in the radioactive beam field: the production of high energy heavy ion beams for use in fragmentation, the spallation of targets with high energy protons, and the acceleration of radioactive beams from low energy to the MeV/u range. 16 refs., 6 figs

Wave fronts of electromagnetic cyclotron harmonic waves

International Nuclear Information System (INIS)

Ohnuma, T.; Watanabe, T.

1982-01-01

In an inhomogeneous high-density magnetized plasma, the spatial properties of the wave fronts and ray trajectories of electromagnetic ordinary and extraordinary cyclotron harmonic waves are investigated. Those waves which are radiated from a local source are found to have wave fronts which are almost parallel to the magnetic field. Also, the reflective properties of the electromagnetic cyclotron harmonic waves are confirmed

Grout for closure of waste-disposal vaults at the US DOE Hanford Site

International Nuclear Information System (INIS)

Wakeley, L.D.; Ernzen, J.J.; McDaniel, E.W.; Voogd, J.

1991-01-01

For permanent disposal of radioactive wastes from reprocessing, the US Department of Energy (DOE) has chosen to grout wastes in concrete vaults within a subsurface multiple-barrier system. The subject of this research is the non-radioactive, or ''cold cap'' grout, which fills the upper 120 cm of these vaults, and provides support for overlying barriers. Because of the heat evolved by the wasteform, this void-filling grout must perform at temperatures higher than those of usual large-volume grouting operations. It must have: low potential for thermal expansion and heat retention; a low modulus to withstand thermal and mechanical stresses without cracking; strength adequate to support overlying barrier-system components; and minimal potential for shrinkage. In addition, it must be pumpable, self-leveling, and non-segregating. Materials for formulation included a large percentage of Class F fly ash, and coarsely ground oil-well cement. Grout development included chemical and physical characterization, and physical and thermal modeling

Anterior vaulting of single piece in-the-bag intraocular lens after blunt trauma

Directory of Open Access Journals (Sweden)

Seung Hoon Oh

2012-01-01

Full Text Available A 64-year-old man complained of difficulty with far vision in the right eye after blunt trauma by his hand during sleep. He had undergone uneventful phacoemulsification and intraocular lens (IOL implantation of both eyes one week before the event. On slit lamp examination, the anterior chamber was shallow compared to postoperative one day or the left eye. After mydriasis, IOL position was perfect, within the capsulorrhexis margin, and no haptics were protruded. SE of his right eye was −4.00 diopter after trauma, although spherical equivalent (SE of both eyes was near emmetropia one day after cataract surgery. We decided on IOL reposition or exchange. Intraoperatively, we pushed the IOL posteriorly; the IOL was vaulted posteriorly, as expected. After surgery, his SE was +0.25 with the same diopter IOL. We report the case on the possibility of 4-point haptic IOL vaulting anteriorly by blunt trauma within the capsular bag.

Current heavy particle medical accelerator programs in Japan

International Nuclear Information System (INIS)

Kawachi, K.

1987-01-01

The first clinical trial of proton radiotherapy in Japan started at National Institute of Radiological Sciences (NIRS) in 1979. The proton which is provided from the NIRS medical cyclotron, has an energy of 70 MeV, and has been used for only superficial or short range tumor therapy. Recently, the cyclotron has been raised the energy up to 90 MeV and a vertical treatment line of protons has been completed in the basement of the cyclotron building. In 1983, Particle Radiation Medical Science Center (PARMS) of the University of Tsukuba started to treat patients with 250 MeV proton beam. The Institute of Physical and Chemical Research (IPCR) has a plan to construct a heavy ion biomedical irradiation facility in the Ring (Separate Sector) Cyclotron building. The facility will be completed in 1989 and will be used for proton and helium ion therapy. Recently, several hospitals have proposed to construct the dedicated proton therapy facilities. The National Cancer Center of Japan, and the PARMS of the University of Tsukuba have taken active parts in such projects. At present time, there is a step to make a decision of the type of accelerators. Another program is a construction of the NIRS Heavy Particle Medical Accelerator which is possible to provide Helium to Argon ions for therapy. The paper describes the accelerators for proton therapy and for heavy ion therapy in some detail

Export of radiopharmaceuticals and establishment of export base of cyclotron

International Nuclear Information System (INIS)

Jung, Kyungil; Kim, Youngsik

2006-01-01

Sam young Unit ech has seized an opportunity to advance into the radiopharmaceuticals market through successful transfer of radiopharmaceuticals manufacturing technology and medical cyclotron, an original technology in nuclear medicine that is the core of less developed areas in nuclear-related fields. The company has continued to push for research development and establishment of market base through industry-academia-research center cooperation with an aim to complement relatively less developed domestic technology and market than in advanced countries, and is making efforts to establish export base in the overseas market based on stabilized supply in the domestic market. As for radiopharmaceuticals, the company is exporting Tc-99m generator to Vietnam, Thailand and the Philippines and preparing itself to export manufacture facilities for Tc-99m generator to Syria and Kazakhstan. In addition, it plans to export 13Mev Cyclotron that has been commercialized after being developed in the domestic market to the U. S. The company plans to grow up to play a pivotal role in the domestic RT area by conducting proactive business activities with an aim to revitalize the domestic market and further domestic original technologies and products in the global market

Final characterization report for the 104-B-1 Tritium Vault and 104-B-2 Tritium Laboratory

International Nuclear Information System (INIS)

Encke, D.B.; Harris, R.A.

1996-11-01

This report is a compilation of the characterization data collected from the 104-B-1 Tritium Vault and the 104-B-2 Trillium Laboratory. The characterization activities were organized and implemented to evaluate the radiological status and identify any hazardous materials. The data contained in this report reflects the current conditions and status of the 104-B-1 Tritium Vault and 104-B-2 Tritium Laboratory. This information is intended to be utilized in support of future building decontamination and demolition, to allow for proper disposal of the demolition debris as required by the Washington Administrative Code, WAC 173-303, the Hanford Site Solid Waste Acceptance Criteria, WHC-EP-0063, and the Environmental Restoration Disposal Facility Waste Acceptance Criteria, BHI-00139. Based on the historical information and facility inspections, the only hazardous materials sampling and analysis activities necessary were to identify lead paint and asbestos containing materials (ACM) in the 104-B-1 Tritium Vault and the 104-B-2 Tritium Laboratory. Asbestos samples were obtained from the outer boundary of the roof areas to confirm the presence and type of asbestos containing fibers. Lead paint samples were obtained to confirm the presence and quantity of lead paint on the roof trim, doors and vents

Status report on the cyclotron

International Nuclear Information System (INIS)

Kormany, Z.

2002-01-01

Complete text of publication follows. The operation of the cyclotron in 2001 was again concentrated to the usual 9 months; January, July and August were reserved for maintenance and holidays. The overall working time of the accelerator was 4300 hours, the breakdown periods amounted to 66 hours last year. The cyclotron was available for users during 3751 hours, the effectively used beam-on-target time is summarized in Table 1. The total time required for machine setup and beam tuning or spent waiting for the start of an irradiation was 272 hours. The control of the adjustable collimators applied in the beam transport system of the cyclotron was renewed during the winter maintenance period. They have been connected to the programmable logic controllers (PLC) and their new control code frees the operators from the long and slow manual setting process. The successful renewal of the control of this and other subsystems (cyclotron and beam transport power supplies) made lots of adjusting and measuring elements on the original control desk needless. To provide more space for the control PCs and remove all unnecessary devices, the unused part of the control desk has been dismantled. The short beam line used mainly for radiation hardness studies was equipped with a new oil-diffusion vacuum system during the summer maintenance. Its components are also connected to the PLC and the same automatic control has been provided like for the other vacuum stands of- the beam transport system. Another short beam line - basically a mirror image of the first one - has also been installed and successfully tested by trial irradiations. (R.P.)

NSun2-Mediated Cytosine-5 Methylation of Vault Noncoding RNA Determines Its Processing into Regulatory Small RNAs

Directory of Open Access Journals (Sweden)

Shobbir Hussain

2013-07-01

Full Text Available Autosomal-recessive loss of the NSUN2 gene has been identified as a causative link to intellectual disability disorders in humans. NSun2 is an RNA methyltransferase modifying cytosine-5 in transfer RNAs (tRNAs, yet the identification of cytosine methylation in other RNA species has been hampered by the lack of sensitive and reliable molecular techniques. Here, we describe miCLIP as an additional approach for identifying RNA methylation sites in transcriptomes. miCLIP is a customized version of the individual-nucleotide-resolution crosslinking and immunoprecipitation (iCLIP method. We confirm site-specific methylation in tRNAs and additional messenger and noncoding RNAs (ncRNAs. Among these, vault ncRNAs contained six NSun2-methylated cytosines, three of which were confirmed by RNA bisulfite sequencing. Using patient cells lacking the NSun2 protein, we further show that loss of cytosine-5 methylation in vault RNAs causes aberrant processing into Argonaute-associated small RNA fragments that can function as microRNAs. Thus, impaired processing of vault ncRNA may contribute to the etiology of NSun2-deficiency human disorders.

Statistical fluctuations in cooperative cyclotron radiation

Science.gov (United States)

Anishchenko, S. V.; Baryshevsky, V. G.

2018-01-01

Shot noise is the cause of statistical fluctuations in cooperative cyclotron radiation generated by an ensemble of electrons oscillating in magnetic field. Autophasing time - the time required for the cooperative cyclotron radiation power to peak - is the critical parameter characterizing the dynamics of electron-oscillators interacting via the radiation field. It is shown that premodulation of charged particles leads to a considerable narrowing of the autophasing time distribution function for which the analytic expression is obtained. When the number of particles Ne exceeds a certain value that depends on the degree to which the particles have been premodulated, the relative root-mean-square deviation (RMSD) of the autophasing time δT changes from a logarithmic dependence on Ne (δT ∼ 1 / lnNe) to square-root (δT ∼ 1 /√{Ne }). A slight energy spread (∼4%) results in a twofold drop of the maximum attainable power of cooperative cyclotron radiation.

Cyclotron resonance cooling by strong laser field

International Nuclear Information System (INIS)

Tagcuhi, Toshihiro; Mima, Kunioka

1995-01-01

Reduction of energy spread of electron beam is very important to increase a total output radiation power in free electron lasers. Although several cooling systems of particle beams such as a stochastic cooling are successfully operated in the accelerator physics, these cooling mechanisms are very slow and they are only applicable to high energy charged particle beams of ring accelerators. We propose here a new concept of laser cooling system by means of cyclotron resonance. Electrons being in cyclotron motion under a strong magnetic field can resonate with circular polarized electromagnetic field, and the resonance take place selectively depending on the velocity of the electrons. If cyclotron frequency of electrons is equal to the frequency of the electromagnetic field, they absorb the electromagnetic field energy strongly, but the other electrons remain unchanged. The absorbed energy will be converted to transverse kinetic energy, and the energy will be dumped into the radiation energy through bremastrahlung. To build a cooling system, we must use two laser beams, where one of them is counter-propagating and the other is co-propagating with electron beam. When the frequency of the counter-propagating laser is tuned with the cyclotron frequency of fast electrons and the co-propagating laser is tuned with the cyclotron frequency of slow electrons, the energy of two groups will approach and the cooling will be achieved. We solve relativistic motions of electrons with relativistic radiation dumping force, and estimate the cooling rate of this mechanism. We will report optimum parameters for the electron beam cooling system for free electron lasers

Cyclotron will not survive yet this year without state support

International Nuclear Information System (INIS)

Marcan, P.

2005-01-01

In this paper the project of the Cyclotron Center of the Slovak republic is described. On the basis of this project the state joint-stock company Biont was constituted. Small cyclotron is in operation; big cyclotron is in process of manufacture and it will be put in operation in 2007. Small cyclotron will be used for production of radiopharmaceuticals. Positron emission tomograph (PET) in Oncological Institute of St. Elizabeth (in Bratislava) and gamma camera in Central Military Hospital (in Ruzomberok) are constituents of the Biont. The PET will be also in Biont. The hadron therapy of ophthalmic tumors is planned. Financial plans of the Biont up to 2009 are presented

General aspects of the cyclotrons and radiochemical separation of: 11 C, 15 O, 18 F and 14 N

International Nuclear Information System (INIS)

Alanis M, J.

1997-07-01

The particle accelerators, as the cyclotrons, are extraordinarily important as tools for the radioisotope production and its application in the area of the medicine. In this time, another method exists for the production of artificial radioisotopes, based on the irradiation of samples with alpha particles or with neutrons coming from a natural radioisotope being obtained a neutron source (Ra + Be, Rn + Be, Po + Be). However, its can be obtained a great quantity of radioisotopes by means of cyclotrons in very short time, compared with other methods. After the second world war, artificial radioisotopes took place by means of reactors and its had many applications, not only medical and in little time the accelerators were manufactured that were more indispensable that the reactors to produce radioisotopes with medical aims. For this reason, the accelerators, in few years became in machines very important for the production of artificial radioisotopes and consequently its were developed techniques of radioactive traces progressively more sophisticated, since it is evident that the production of radioactive nuclei through nuclear reactors its cannot satisfy all the demands. In general terms, only the neutrons can be used as nuclear projectiles in reactors and as a result, the production spectra of radioisotopes is limited and as alternative it is unavoidable that the cyclotrons are a good tool for this end. The use of a cyclotron to produce radioisotopes, it can be justified, only if the following conditions are completed. 1. If the radioisotopes of an element produced in a reactor don't favor with the nuclear properties for the purposes of the traced studies, for example: if the half life is very short or very big, if the decay system not to suit him. 2. If the wanted radioisotope cannot produce in the reactor with enough specific activity. (Author)