WorldWideScience

Sample records for med cox orange

  1. "Cox orange\\" and \\"Elstar\\" Apple Cultivars

    African Journals Online (AJOL)

    Thinning trials were conducted in the apple orchards of Klein Altendorf experimental station near Bonn, Germany, using 7 year old CV, \\'Cox orange\\' in the year 2001 and 8 year old \\'Elstar\\' apple trees in 2002. The objective was to reduce the number of fruits per tree, yield, improve fruit quality, overcome alternate bearing ...

  2. Induced mutants of Cox's Orange Pippin apple with apparent increased self-compatibility. Pt. 2

    International Nuclear Information System (INIS)

    Church, R.M.; Lacey, C.N.D.; Richardson, P.

    1982-01-01

    Fruit set on clones of Cox's Orange Pippin apple which had been produced by gamma-irradiation, and found in a previous trial to crop when isolated from the pollen of other cultivars, was compared after open or hand-pollination. Some clones set more fruit than the unirradiated control trees when open pollinated or when hand-pollinated with pollen from the same tree or control Cox trees. Pollen from some mutant clones also improved set on standard Cox (EMLA). Estimates of the numbers of pollen tubes reaching the base of the style indicated that the increased set was due to enhanced tube growth. (orig.)

  3. The drop of flowers and fruits in apple, with special reference to the June drop of Cox's orange pippin and its control with growth regulators

    NARCIS (Netherlands)

    Wertheim, S.J.

    1971-01-01

    To study possibilities for increases of yield of the apple cultivar Cox's Orange Pippin, relevant information was gathered about fruit set and fruit drop, in particular about June drop. The information concerned pollination intensity, amount of fruit set, seed content of the fruit, number

  4. Optimization of Acid Orange 7 Degradation in Heterogeneous Fenton-like Reaction Using Fe3-xCoxO4 Catalyst

    Science.gov (United States)

    Ibrahim, M. Z.; Alrozi, R.; Zubir, N. A.; Bashah, N. A.; Ali, S. A. Md; Ibrahim, N.

    2018-05-01

    The oxidation process such as heterogeneous Fenton and/or Fenton-like reactions is considered as an effective and efficient method for treatment of dye degradation. In this study, the degradation of Acid Orange 7 (AO7) was investigated by using Fe3-xCoxO4 as a heterogeneous Fenton-like catalyst. Response surface methodology (RSM) was used to optimize the operational parameters condition and the interaction of two or more parameters. The parameter studies were catalyst dosage (X1 ), pH (X2 ) and H2O2 concentration (X3 ) towards AO7 degradation. Based on analysis of variance (ANOVA), the derived quadratic polynomial model was significant whereby the predicted values matched the experimental values with regression coefficient of R2 = 0.9399. The optimum condition for AO7 degradation was obtained at catalyst dosage of 0.84 g/L, pH of 3 and H2O2 concentration of 46.70 mM which resulted in 86.30% removal of AO7 dye. These findings present new insights into the influence of operational parameters in the heterogeneous Fenton-like oxidation of AO7 using Fe3-xCoxO4 catalyst.

  5. Differential Lipid Composition and Gene Expression in the Semi-Russeted “Cox Orange Pippin” Apple Variety

    Directory of Open Access Journals (Sweden)

    Sylvain Legay

    2017-09-01

    Full Text Available Russeting is characterized by a particular rough and brown phenotype, which is mainly due to the accumulation of suberin in the inner part of the epidermal cell walls. In our previous bulk transcriptomic analysis, comparing fully russeted, and waxy apple varieties, showed, in apple fruit skin, a massive decreased expression of cutin, wax and some pentacyclic triterpene biosynthesis genes in the russeted varieties, with an expected concomitant enhanced expression of the suberin biosynthetic genes. In the present work, we performed a deep investigation of the aliphatic composition of the cutin, suberin, waxes, and triterpenes in the waxy and russeted patches of the semi-russeted apple variety “Cox Orange Pippin.” A targeted gene expression profiling was performed to validate candidate genes which were identified in our previous work and might be involved in the respective metabolic pathways. Our results showed that a decrease of cuticular waxes, ursolic acid and oleanolic acid, accompanied by an accumulation of alkyl-hydroxycinamates and betulinic acid, occurs in the russeted patches. The suberin monomer composition is characterized by specific occurrence of 20, 22, and 24 carbon aliphatic chains, whereas cutin is mainly represented by common C16 and C18 aliphatic chains. This work depicts, for the first time in apple, the complex composition of suberin, cutin, waxes and triterpenes, and confirms the strong interplay between these epidermal polymers in apple fruit skin.

  6. The characteristics and stability of a range of Cox's Orange Pippin apple mutants showing different growth habits

    International Nuclear Information System (INIS)

    Lacey, C.N.D.; Campbell, A.I.

    1979-01-01

    Seven hundred and fifty gamma-irradiated scions of Cox's Orange Pippin apple were grown to produce a V 1 generation and were then multiplied to produce a V 2 of 13158 individual trees. 272 obvious vegetative mutants, mainly dwarf or compact types, were found in this population and classified according to growth habit. These were propagated to produce clones of the mutant types (V 3 ) and a study of these clonal mutants as compared with their original (V 2 ) characteristics showed that while the vast majority of the selected mutants produced dwarf or compact clones, no clear indication of final cropping performance could be drawn from the original phenotype of the selected V 2 mutants. The majority of mutants produced were not of commercial value, and the main reasons for the rejection of V 3 clones depended, in many cases, on the phenotype of the V 2 selection. Thus while all types of V 2 mutant produced approximately the same proportion of acceptable trees, the reason for the rejection of the V 3 clones varies with the V 2 phenotype. Therefore selection can be carried out at an early stage in a mutation breeding programme to reduce the proportion of certain unwanted types such as mericlinal chimaeras as that otherwise are carried forward to yield trials. From the orchard trials of 82 mutant clones. 24 were short-listed for possible commercial introduction. All were derived from the less extreme mutant types. (Auth.)

  7. PSIKOLOGI KORUPSI NOVEL ORANG-ORANG PROYEK KARYA AHMAD TOHARI

    OpenAIRE

    Farid Faruq; Saiful Anam

    2017-01-01

    This study aimed to obtain a description of personality (nature) can affect the behavior of corruption in the novel Orang-Orang Proyek. This research is a descriptive qualitative study using a novel approach to analyze the psychology of corruption. The data in this study are words, phrases, and sentences contained in the novel Orang-Orang Proyek. The main data sources are novel by Ahmad Tohari. Data collection method used in this research is to read the text repeatedly novel Orang-Orang Proye...

  8. Identification and characterization of carprofen as a multi-target FAAH/COX inhibitor

    Science.gov (United States)

    Favia, Angelo D.; Habrant, Damien; Scarpelli, Rita; Migliore, Marco; Albani, Clara; Bertozzi, Sine Mandrup; Dionisi, Mauro; Tarozzo, Glauco; Piomelli, Daniele; Cavalli, Andrea; De Vivo, Marco

    2013-01-01

    Pain and inflammation are major therapeutic areas for drug discovery. Current drugs for these pathologies have limited efficacy, however, and often cause a number of unwanted side effects. In the present study, we identify the non-steroid anti-inflammatory drug, carprofen, as a multi-target-directed ligand that simultaneously inhibits cyclooxygenase-1 (COX-1), COX-2 and fatty acid amide hydrolase (FAAH). Additionally, we synthesized and tested several racemic derivatives of carprofen, sharing this multi-target activity. This may result in improved analgesic efficacy and reduced side effects (Naidu, et al (2009) J Pharmacol Exp Ther 329, 48-56; Fowler, C.J. et al. (2012) J Enzym Inhib Med Chem Jan 6; Sasso, et al (2012) Pharmacol Res 65, 553). The new compounds are among the most potent multi-target FAAH/COXs inhibitors reported so far in the literature, and thus may represent promising starting points for the discovery of new analgesic and anti-inflammatory drugs. PMID:23043222

  9. PSIKOLOGI KORUPSI NOVEL ORANG-ORANG PROYEK KARYA AHMAD TOHARI

    Directory of Open Access Journals (Sweden)

    Farid Faruq

    2017-08-01

    Full Text Available This study aimed to obtain a description of personality (nature can affect the behavior of corruption in the novel Orang-Orang Proyek. This research is a descriptive qualitative study using a novel approach to analyze the psychology of corruption. The data in this study are words, phrases, and sentences contained in the novel Orang-Orang Proyek. The main data sources are novel by Ahmad Tohari. Data collection method used in this research is to read the text repeatedly novel Orang-Orang Proyek, collect any data relating to the focus of the study, after carrying out the classification. Data analysis technique is done by data identification, data reduction, data display, data interpretation, describe the results of the analysis, and draw conclusions. While the results of this study are as followsdescription of personalitycovetousness/greed and consumptive lifestyles nature conducted by figures such novel Dalkijo and their families can lead to corruption. This means that there is influence, greed / avarice as well as the nature of the consumer lifestyle on corruption.

  10. The dependence of orange-red IRSL decay curves of potassium feldspars on sample temperature

    International Nuclear Information System (INIS)

    Fattahi, Morteza

    2004-01-01

    This paper presents the effects of stimulation temperature on the infrared stimulated orange-red (600-650 nm) luminescence emission (orange-red infrared simulated luminescence (IRSL)) in potassium feldspar. Investigations explore the relationship between initial (0-2 s), integral (0-100 s), net initial (0-2 s less background over 2 s), net integral (0-100 s less background over 100 s) and last 2 s of the orange-red IRSL signals obtained for 100 s versus stimulation temperature (20-460 degree sign C) on both unpreheated and preheated samples. In the potassium feldspar sample examined, competition effects, including thermal enhancement, depletion and possibly quenching affect the orange-red IRSL signals measured. Observed effects (e.g., thermal enhancement, thermal activation energy and the decay rate) over the temperature range 20-120 degree sign C may be explained by tunnelling luminescence processes, IR transitions to the conduction band following excitations from ground state of electron trap by acquiring thermal energy from the lattice and or the random-walk band-tail model. Preheating prior to orange-red IRSL and Thermoluminescence (TL) measurements provides evidence that there are both shallow and deep traps responsible for low- and high-temperature orange-red IRSL and TL peaks. The effects of both preheating and IR bleaching on the orange-red thermally stimulated luminescence (red emission during thermoluminescence, RTL) provide evidence that bleached RTL traps have no significant contribution in the production of orange-red IRSL signals

  11. Cox1 mutation abrogates need for Cox23 in cytochrome c oxidase biogenesis

    Directory of Open Access Journals (Sweden)

    Richard Dela Cruz

    2016-06-01

    Full Text Available Cox23 is a known conserved assembly factor for cytochrome c oxidase, although its role in cytochrome c oxidase (CcO biogenesis remains unresolved. To gain additional insights into its role, we isolated spontaneous suppressors of the respiratory growth defect in cox23∆ yeast cells. We recovered independent colonies that propagated on glycerol/lactate medium for cox23∆ cells at 37°C. We mapped these mutations to the mitochondrial genome and specifically to COX1 yielding an I101F substitution. The I101F Cox1 allele is a gain-of-function mutation enabling yeast to respire in the absence of Cox23. CcO subunit steady-state levels were restored with the I101F Cox1 suppressor mutation and oxygen consumption and CcO activity were likewise restored. Cells harboring the mitochondrial genome encoding I101F Cox1 were used to delete genes for other CcO assembly factors to test the specificity of the Cox1 mutation as a suppressor of cox23∆ cells. The Cox1 mutant allele fails to support respiratory growth in yeast lacking Cox17, Cox19, Coa1, Coa2, Cox14 or Shy1, demonstrating its specific suppressor activity for cox23∆ cells.

  12. Agent Orange exposure, Vietnam War veterans, and the risk of prostate cancer.

    Science.gov (United States)

    Chamie, Karim; DeVere White, Ralph W; Lee, Dennis; Ok, Joon-Ha; Ellison, Lars M

    2008-11-01

    It has been demonstrated that Agent Orange exposure increases the risk of developing several soft tissue malignancies. Federally funded studies, now nearly a decade old, indicated that there was only a weak association between exposure and the subsequent development of prostate cancer. Because Vietnam War veterans are now entering their 60s, the authors reexamined this association by measuring the relative risk of prostate cancer among a cohort of men who were stratified as either exposed or unexposed to Agent Orange between the years 1962 and 1971 and who were followed during the interval between 1998 and 2006. All Vietnam War era veterans who receive their care in the Northern California Veteran Affairs Health System were stratified as either exposed (n=6214) or unexposed (n=6930) to Agent Orange. Strata-specific incidence rates of prostate cancer (International Classification of Diseases, 9th Revision code 185.0) were calculated. Differences in patient and disease characteristics (age, race, smoking history, family history, body mass index, finasteride exposure, prebiopsy prostate-specific antigen (PSA) level, clinical and pathologic stage, and Gleason score) were assessed with chi-square tests, t tests, a Cox proportional hazards model, and multivariate logistic regression. Twice as many exposed men were identified with prostate cancer (239 vs 124 unexposed men, respectively; odds ratio [OR], 2.19; 95% confidence interval [95% CI], 1.75-2.75). This increased risk also was observed in a Cox proportional hazards model from the time of exposure to diagnosis (hazards ratio [HR], 2.87; 95% CI, 2.31-3.57). The mean time from exposure to diagnosis was 407 months. Agent Orange-exposed men were diagnosed at a younger age (59.7 years; 95% CI, 58.9-60.5 years) compared with unexposed men (62.2 years; 95% CI, 60.8-63.6 years), had a 2-fold increase in the proportion of Gleason scores 8 through 10 (21.8%; 95% CI, 16.5%-27%) compared with unexposed men (10.5%; 95% CI, 5

  13. Agent Orange

    Science.gov (United States)

    ... DOD Clinical Practice Guidelines Access and Quality Data Medical Inspector Patient Safety ... Orange was a tactical herbicide used by the U.S. military from 1962 to 1975, named for the orange band around the storage barrel. The military sprayed millions ...

  14. 21 CFR 146.135 - Orange juice.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 2 2010-04-01 2010-04-01 false Orange juice. 146.135 Section 146.135 Food and....135 Orange juice. (a) Orange juice is the unfermented juice obtained from mature oranges of the... name of the food is “orange juice”. The name “orange juice” may be preceded on the label by the...

  15. Photostability of Natural Orange-Red and Yellow Fungal Pigments in Liquid Food Model Systems

    DEFF Research Database (Denmark)

    Mapari, Sameer Shamsuddin; Meyer, Anne S.; Thrane, Ulf

    2009-01-01

    The variation in the photostability among the currently authorized natural pigments limits their application span to a certain type of food system, and more robust alternatives are being sought after to overcome this problem. In the present study, the photostability of an orange-red and a yellow...... an enhanced photostability of fungal pigment extracts compared to the commercially available natural colorants Monascus Red and turmeric used as controls. Yellow components of the orange-red fungal pigment extract were more photostable than the red components. Chemistry of the photodegradation of the orange...

  16. ORANGE: RANGE OF BENEFITS

    OpenAIRE

    Parle Milind; Chaturvedi Dev

    2012-01-01

    No wonder that oranges are one of the most popular fruits in the world. Orange (citrus sinensis) is well known for its nutritional and medicinal properties throughout the world. From times immemorial, whole Orange plant including ripe and unripe fruits, juice, orange peels, leaves and flowers are used as a traditional medicine. Citrus sinensis belongs to the family Rutaceae. The fruit is a fleshy, indehiscent, berry that ranges widely in size from 4 cm to 12 cm. The major medicinal proper...

  17. Redox chemistry of orange I and orange II: a pulse radiolysis study

    International Nuclear Information System (INIS)

    Yadav, P.; Sharma, K.K.; Rao, B.S.M.; O'Neill, P.; Oakes, J.; Batchelor, S.N.

    2004-01-01

    The relative reactivities of different tautomeric forms of model azo dyes (Orange I and Orange II) with oxidising and reducing radicals are investigated using pulse radiolysis technique. The rate of the reaction of N 3 with Orange I is diffusion controlled and the order of the reactivity among the tautomers is common ion > hydrazone > azo, whereas a reverse trend was seen in the reaction of e aq . The reducing alcohol radicals react with Orange II with k values in the range (1-3) x 10 9 dm 3 mol -1 s -1 . The relevant reaction mechanism is discussed. (author)

  18. COX-1 vs. COX-2 as a determinant of basal tone in the internal anal sphincter.

    Science.gov (United States)

    de Godoy, Márcio A F; Rattan, Neeru; Rattan, Satish

    2009-02-01

    Prostanoids, produced endogenously via cyclooxygenases (COXs), have been implicated in the sustained contraction of different smooth muscles. The two major types of COXs are COX-1 and COX-2. The COX subtype involved in the basal state of the internal anal sphincter (IAS) smooth muscle tone is not known. To identify the COX subtype, we examined the effect of COX-1- and COX-2-selective inhibitors, SC-560 and rofecoxib, respectively, on basal tone in the rat IAS. We also determined the effect of selective deletion of COX-1 and COX-2 genes (COX-1(-/-) and COX-2(-/-) mice) on basal tone in murine IAS. Our data show that SC-560 causes significantly more efficacious and potent concentration-dependent decreases in IAS tone than rofecoxib. In support of these data, significantly higher levels of COX-1 than COX-2 mRNA were found in the IAS. In addition, higher levels of COX-1 mRNA and protein were expressed in rat IAS than rectal smooth muscle. In wild-type mice, IAS tone was decreased 41.4 +/- 3.4% (mean +/- SE) by SC-560 (1 x 10(-5) M) and 5.4 +/- 2.2% by rofecoxib (P IAS from wild-type mice and significantly less (0.080 +/- 0.015 mN/mg) in the IAS from COX-1(-/-) mice (P IAS tone.

  19. Properties of spatial Cox process models

    DEFF Research Database (Denmark)

    Møller, Jesper

    Probabilistic properties of Cox processes of relevance for statistical modelling and inference are studied. Particularly, we study the most important classes of Cox processes, including log Gaussian Cox processes, shot noise Cox processes, and permanent Cox processes. We consider moment properties...... and point process operations such as thinning, displacements, and superpositioning. We also discuss how to simulate specific Cox processes....

  20. Pregnancy induced changes in Cox-1, Cox-2 and NOSIII vascular and renal expression.

    Science.gov (United States)

    Bobadilla, Rosa A; Bracho, Ismael; Alvarez, Victor M Pérez; Anguiano, Liliana; López, Pedro

    2004-01-01

    In order to establish if there is a mutual regulation between COX and NOS in vascular and renal tissue during pregnancy, we measured the protein expression of COX-1, COX-2 and NOSIII by Western blot comparing the thoracic and abdominal aorta and the renal cortex and medulla of non pregnant and pregnant (21st day) Wistar rats. We found there was no difference in the quantity of protein of any of the two isoforms of COX between the two segments of the aorta of non pregnant animals while an increased expression of both COX-1 And COX-2 was found in the abdominal compared to the thoracic segment of the pregnant rats. An increased expression of NOS III was found in the abdominal segment of the aorta form pregnant rats. No changes were found between pregnant and no pregnant animals in the expression of COX-1 and COX-2 in the renal cortex or medulla while an increased expression of NOS III was found in the cortex from pregnant compared to non pregnant animals. These results suggest the influence of pregnancy is not homogeneous along the aorta and also that a balance between prostaglandins and nitric oxide is responsible of the blunted vascular reactivity during pregnancy in the rat.

  1. Properties of spatial Cox process models

    DEFF Research Database (Denmark)

    Møller, Jesper

    2005-01-01

    Particularly, we study the most important classes of Cox processes, including log Gaussian Cox processes, shot noise Cox processes, and permanent Cox processes. We consider moment properties and point process operations such as thinning, displacements, and super positioning. We also discuss how...... to simulate specific Cox processes....

  2. Lévy based Cox point processes

    DEFF Research Database (Denmark)

    Hellmund, Gunnar; Prokesová, Michaela; Jensen, Eva Bjørn Vedel

    2008-01-01

    In this paper we introduce Lévy-driven Cox point processes (LCPs) as Cox point processes with driving intensity function Λ defined by a kernel smoothing of a Lévy basis (an independently scattered, infinitely divisible random measure). We also consider log Lévy-driven Cox point processes (LLCPs......) with Λ equal to the exponential of such a kernel smoothing. Special cases are shot noise Cox processes, log Gaussian Cox processes, and log shot noise Cox processes. We study the theoretical properties of Lévy-based Cox processes, including moment properties described by nth-order product densities...

  3. 21 CFR 74.250 - Orange B.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 1 2010-04-01 2010-04-01 false Orange B. 74.250 Section 74.250 Food and Drugs... ADDITIVES SUBJECT TO CERTIFICATION Foods § 74.250 Orange B. (a) Identity. (1) The color additive Orange B is.... (2) The diluents in color additive mixtures for food use containing Orange B are limited to those...

  4. 21 CFR 146.141 - Canned orange juice.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 2 2010-04-01 2010-04-01 false Canned orange juice. 146.141 Section 146.141 Food... Beverages § 146.141 Canned orange juice. (a) Canned orange juice is the food prepared from orange juice as specified in § 146.135 or frozen orange juice as specified in § 146.137, or a combination of both, to which...

  5. 21 CFR 146.137 - Frozen orange juice.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 2 2010-04-01 2010-04-01 false Frozen orange juice. 146.137 Section 146.137 Food... Beverages § 146.137 Frozen orange juice. (a) Frozen orange juice is orange juice as defined in § 146.135, except that it is frozen. (b) The name of the food is “Frozen orange juice”. Such name may be preceded on...

  6. Generalised shot noise Cox processes

    DEFF Research Database (Denmark)

    Møller, Jesper; Torrisi, Giovanni Luca

    2005-01-01

    We introduce a class of cox cluster processes called generalised shot noise Cox processes (GSNCPs), which extends the definition of shot noise Cox processes (SNCPs) in two directions: the point process that drives the shot noise is not necessarily Poisson, and the kernel of the shot noise can...

  7. Pharmacologic inhibition of COX-1 and COX-2 in influenza A viral infection in mice.

    Directory of Open Access Journals (Sweden)

    Michelle A Carey

    Full Text Available BACKGROUND: We previously demonstrated that cyclooxygenase (COX-1 deficiency results in greater morbidity and inflammation, whereas COX-2 deficiency leads to reduced morbidity, inflammation and mortality in influenza infected mice. METHODOLOGY/PRINCIPAL FINDINGS: We investigated the effects of COX-1 and COX-2 inhibitors in influenza A viral infection. Mice were given a COX-1 inhibitor (SC-560, a COX-2 inhibitor (celecoxib or no inhibitor beginning 2 weeks prior to influenza A viral infection (200 PFU and throughout the course of the experiment. Body weight and temperature were measured daily as indicators of morbidity. Animals were sacrificed on days 1 and 4 post-infection and bronchoalveolar lavage (BAL fluid was collected or daily mortality was recorded up to 2 weeks post-infection. Treatment with SC-560 significantly increased mortality and was associated with profound hypothermia and greater weight loss compared to celecoxib or control groups. On day 4 of infection, BAL fluid cells were modestly elevated in celecoxib treated mice compared to SC-560 or control groups. Viral titres were similar between treatment groups. Levels of TNF-alpha and G-CSF were significantly attenuated in the SC-560 and celecoxib groups versus control and IL-6 levels were significantly lower in BAL fluid of celecoxib treated mice versus control and versus the SC-560 group. The chemokine KC was significantly lower in SC-560 group versus control. CONCLUSIONS/SIGNIFICANCE: Treatment with a COX-1 inhibitor during influenza A viral infection is detrimental to the host whereas inhibition of COX-2 does not significantly modulate disease severity. COX-1 plays a critical role in controlling the thermoregulatory response to influenza A viral infection in mice.

  8. Adverse Effects of COX-2 Inhibitors

    Directory of Open Access Journals (Sweden)

    Jagdish N. Sharma

    2005-01-01

    Full Text Available Cyclooxygenase-2 selective inhibitors (COXIBs were developed with the prime object of minimizing gastrointestinal adverse effects, which are seen with the use of traditional nonsteroidal anti-inflammatory drugs (NSAIDs. Their long-term use is limited by the development of hypertension, edema, and congestive heart failure in a significant proportion of patients. NSAIDs block the activity of both COX isozymes, COX-1 and COX-2, which mediate the enzymatic conversion of arachidonate to prostaglandin H2 (PGH2 and other prostaglandin (PG metabolites. It is well established that the cardiovascular profile of COX-2 inhibitors can be accounted for by inhibition of COX-dependent PG synthesis. Following the COX-mediated synthesis of PGH2 from arachidonate, PGH2 is metabolized to one of at least five bioactive PGs, including PGE2, PGI2, PGF2, PGD2, or thromboxane A2 (TXA2. These prostanoids have pleiotropic cardiovascular effects, altering platelet function and renal function, and they are acting either as vasodilators or vasoconstrictors. Although COX-1 and COX-2 exhibit similar biochemical activity in converting arachidonate to PGH2in vitro, the ultimate prostanoids they produce in vivo may be different due to differential regulation of COX-1 and COX-2, tissue distribution, and availability of the prostanoid synthases. PGs have been established as being critically involved in mitigating hypertension, helping to maintain medullary blood flow (MBF, promoting urinary salt excretion, and preserving the normal homeostasis of thrombosis, and the researchers found that the use of COX-2 inhibitors caused many serious complications in altering the normal body homeostasis. The purpose of the present research is to explain briefly the side effects of COX-2 inhibitors on the renal and cardiovascular system.

  9. 21 CFR 146.140 - Pasteurized orange juice.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 2 2010-04-01 2010-04-01 false Pasteurized orange juice. 146.140 Section 146.140... and Beverages § 146.140 Pasteurized orange juice. (a) Pasteurized orange juice is the food prepared from unfermented juice obtained from mature oranges as specified in § 146.135, to which may be added...

  10. 21 CFR 146.151 - Orange juice for manufacturing.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 2 2010-04-01 2010-04-01 false Orange juice for manufacturing. 146.151 Section... Fruit Juices and Beverages § 146.151 Orange juice for manufacturing. (a) Orange juice for manufacturing... from oranges as provided in § 146.135, except that the oranges may deviate from the standards for...

  11. Operation Orange Street Resurfacing 2016

    Data.gov (United States)

    City of Jackson, Mississippi — Track Operation Orange Cone projects for 2016. “Operation Orange Cone” is an initiative launched in 2015 as part of the Yarber Administration’s push to address the...

  12. Palm distributions for log Gaussian Cox processes

    DEFF Research Database (Denmark)

    Coeurjolly, Jean-Francois; Møller, Jesper; Waagepetersen, Rasmus Plenge

    2017-01-01

    This paper establishes a remarkable result regarding Palm distributions for a log Gaussian Cox process: the reduced Palm distribution for a log Gaussian Cox process is itself a log Gaussian Cox process that only differs from the original log Gaussian Cox process in the intensity function. This new...... result is used to study functional summaries for log Gaussian Cox processes....

  13. SEKULARISASI DALAM PANDANGAN HARVEY COX

    Directory of Open Access Journals (Sweden)

    Fauzan Fauzan

    2017-02-01

    Full Text Available Sebagian besar kaum agamawan (ortodoks memandang sekularisasi sebagai ancaman terhadap eksistensi agama. Namun sebaliknya, Harvey Cox memandang sekularisasi sebagai teologi perubahan sosial yang bertujuan mendobrak kebuntuan agama yang terbelenggu oleh ide “pemeliharaan” dan “kemapanan”. Tulisan ini membahas pandangan Harvey Cox tentang sekularisasi, konsepnya tentang Kota Sekuler (Secular City, dan Tuhan pada masyarakat sekuler. Cox melihat sekularisasi merupakan sebuah keniscayaan sejarah. Sekularisasi merupakan gerakan yang membebaskan manusia dari dogma yang membelenggu kebebasan manusia. Melalui simbol Kota Sekuler, Cox menghadirkan paradigma teologi yang lebih sesuai dengan keadaan masyarakat modern saat ini. Cox melihat bahwa Tuhan sebagaimana yang diajarkan oleh Kristiani –juga agama lain– bukanlah Tuhan yang sebenarnya. Tuhan tak lebih dari sebuah penamaan yang kehadirannya terkadang kosong dan ambigu. Semenjak penamaan dilekatkan dalam lingkungan sosio kultural tertentu, maka kata “Tuhan” tidak suci lagi. Apabila Tuhan dimaknai secara “ketat” dalam ruang tradisi yang berbeda-beda, maka akan terjadi benturan yang terkadang membutuhkan pengorbanan jiwa.

  14. Application of Acid Whey in Orange Drink Production

    Directory of Open Access Journals (Sweden)

    Grażyna Jaworska

    2013-01-01

    Full Text Available The aim of this study is to compare qualitative changes in orange and orange beverages containing whey during 12 months of storage. The beverages contained 12 % extract, half of which was orange concentrate, the rest was sugar or sugar and whey extract. Acid whey was used in the production of beverages, added at a rate of 50 % of the used water. Orange beverages with whey contained more protein, ash, glucose, lactose and vitamin B2 than the orange beverages, but less sucrose, fructose and vitamin C, and also showed lower antioxidant activity against the DPPH radical. No significant differences between the two types of beverages were found in the polyphenolic content or activity against the ABTS cation radical. The type of beverage had a significant effect on the colour parameter values under the CIELAB system, although no significant differences were found between the beverages in the sensory evaluation of colour desirability. The overall sensory evaluation of orange beverages with whey was 2–10 % lower than of other orange beverages. The intensity of orange, sweet and refreshing taste was greater in orange beverages, while that of sour and whey taste was greater in orange beverages containing whey. There were significant decreases in sucrose, lactose, all indicators of antioxidant activity and sensory quality during storage. Levels of glucose and fructose rose with the storage period, while the intensity of sour, orange and refreshing taste decreased.

  15. t-Butyl group-substituted triphenylamine-containing orange-red fluorescent emitters for organic light-emitting diodes

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Kum Hee; Kim, Chi Sik [Department of Chemistry, Sungkyunkwan University, Suwon, 440-746 (Korea, Republic of); Kim, Young Kwan, E-mail: kimyk@hongik.ac.kr [Department of Information Display, Hongik University, Seoul 121-791 (Korea, Republic of); Yoon, Seung Soo, E-mail: ssyoon@skku.edu [Department of Chemistry, Sungkyunkwan University, Suwon, 440-746 (Korea, Republic of)

    2012-03-30

    Efficient orange-red fluorescent compounds, 4-(dicyanomethylene)-2-adamantyl-6-(4-(N-(4-tert-butylphenyl) -N-(3,5-di-tert-butylphenyl)amino)benzene)vinyl-4H-pyran (DCATP) and 2,6-bis[4-(N-(4-tert-butylphenyl)-N-(3,5-di-tert-butylphenyl)amino)benzene] vinyl-4-(dicyanomethylene)-4H-pyran (BDCTP) containing the tert-butylated triphenylamine in donor moieties, were synthesized and characterized. In these red emitters, bulky groups, such as t-butyl group and adamantane were introduced to increase the steric hindrance between the red emitters. In particular, an efficient orange-red device containing the emitter DCATP as a dopant showed a luminous and power efficiency of 6.87 cd/A and 2.70 lm/W, respectively, at 20 mA/cm{sup 2} with the CIE coordinates of (0.48, 0.50) at 7.0 V. In addition, an efficient red organic light-emitting diode using BDCTP as a dopant exhibited a luminous and power efficiency of 2.30 cd/A and 1.31 lm/W, respectively, at 20 mA/cm{sup 2} and CIE coordinates of (0.61, 0.39). - Highlights: Black-Right-Pointing-Pointer Two orange-red emitters with t-butylated triphenylamine derivatives were studied. Black-Right-Pointing-Pointer We examine changes in electron D-A and electron D-A-D type in the terminal groups. Black-Right-Pointing-Pointer Electron D-A-D type material shows improved color chromaticity.

  16. 21 CFR 146.150 - Canned concentrated orange juice.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 2 2010-04-01 2010-04-01 false Canned concentrated orange juice. 146.150 Section... Fruit Juices and Beverages § 146.150 Canned concentrated orange juice. (a) Canned concentrated orange... labeling of ingredients prescribed for frozen concentrated orange juice by § 146.146, except that it is not...

  17. 21 CFR 146.152 - Orange juice with preservative.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 2 2010-04-01 2010-04-01 false Orange juice with preservative. 146.152 Section... Fruit Juices and Beverages § 146.152 Orange juice with preservative. (a) Orange juice with preservative... of orange juice for manufacturing as provided for in § 146.151, except that a preservative is added...

  18. Regulation of COX and LOX by curcumin.

    Science.gov (United States)

    Rao, Chinthalapally V

    2007-01-01

    Turmeric (Curcuma longa) is extensively used as a household remedy for various diseases. For the last few decades, work has been done to establish the biological activities and pharmacological actions of curcumin, the principle constituent of turmeric. Curcumin has proven to be beneficial in the prevention and treatment of a number of inflammatory diseases due to its anti-inflammatory activity. Arachidonic acid-derived lipid mediators that are intimately involved in inflammation are biosynthesized by pathways dependent on cyclooxygenase (COX) and lipoxygenase (LOX) enzymes. The role of LOX and COX isoforms, particularly COX-2, in the inflammation has been well established. At cellular and molecular levels, curcumin has been shown to regulate a number of signaling pathways, including the eicosanoid pathway involving COX and LOX. A number of studies have been conducted that support curcumin-mediated regulation of COX and LOX pathways, which is an important mechanism by which curcumin prevents a number of disease processes, including the cancer. The specific regulation of 5-LOX and COX-2 by curcumin is not fully established; however, existing evidence indicates that curcumin regulates LOX and COX-2 predominately at the transcriptional level and, to a certain extent, the posttranslational level. Thus, the curcumin-selective transcriptional regulatory action of COX-2, and dual COX/LOX inhibitory potential of this naturally occurring agent provides distinctive advantages over synthetic COX/LOX inhibitors, such as nonsteroidal anti-inflammatory drugs. In this review, we discuss evidence that supports the regulation of COX and LOX enzymes by curcumin as the key mechanism for its beneficial effects in preventing various inflammatory diseases.

  19. Heavy metals in navel orange orchards of Xinfeng County and their transfer from soils to navel oranges.

    Science.gov (United States)

    Cheng, Jinjin; Ding, Changfeng; Li, Xiaogang; Zhang, Taolin; Wang, Xingxiang

    2015-12-01

    This study investigated heavy metal concentrations in soils and navel oranges of Xinfeng County, a well-known navel orange producing area of China. The results showed that the average concentrations of lead (Pb), cadmium (Cd), chromium (Cr), arsenic (As) and mercury (Hg) in orchard soils all increased compared to the regional background values, especially for Cd, which increased by 422%. When compared to the Chinese Environmental Quality Standard for soil (GB15618-1995), Pb, Cr and Hg concentrations in all orchard soil samples were below the limit standards, but Cd concentrations in 24 soil samples (21%) and As concentrations in 8 soil samples (7%) exceeded the limit standards. However, concentrations of all heavy metals in navel orange pulps were within the National Food Safety Standard of China (GB 2762-2012). Dietary risk assessment also showed that the exposure to these five heavy metals by consumption of navel oranges could hardly pose adverse health effects on adults and children. Since the range and degree of soil Cd pollution was widest and the most severe of all, Cd was taken as an example to reveal the transfer characteristics of heavy metals in soil-navel orange system. Cd concentrations in different organs of navel orange trees decreased in the following order: root>leaf>peel>pulp. That navel oranges planted in the Cd contaminated soils were within the national food safety standard was mainly due to the low transfer factor for Cd from soil to pulp (TFpulp). Further studies showed that TFpulp was significantly negatively correlated with soil pH, organic carbon (OC) and cation exchange capacity (CEC). Based on these soil properties, a prediction equation for TFpulp was established, which indicated that the risk for Cd concentration of navel orange pulp exceeding the national food limit is generally low, when soil Cd concentration is below 7.30 mg/kg. If appropriate actions are taken to increase soil pH, OC and CEC, Cd concentrations in navel orange pulps

  20. 21 CFR 146.145 - Orange juice from concentrate.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 2 2010-04-01 2010-04-01 false Orange juice from concentrate. 146.145 Section 146... Juices and Beverages § 146.145 Orange juice from concentrate. (a) Orange juice from concentrate is the food prepared by mixing water with frozen concentrated orange juice as defined in § 146.146 or with...

  1. 21 CFR 146.146 - Frozen concentrated orange juice.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 2 2010-04-01 2010-04-01 false Frozen concentrated orange juice. 146.146 Section... Fruit Juices and Beverages § 146.146 Frozen concentrated orange juice. (a) Frozen concentrated orange juice is the food prepared by removing water from the juice of mature oranges as provided in § 146.135...

  2. Radioprotection of intestinal crypt cells by cox-inhibitors

    International Nuclear Information System (INIS)

    Bisnar, Paul O.; Dones, Rosa Angela S.A.; Serna, Paulene-Ver A.; Deocaris, Chester C.; Guttierez, Kalangitan V.; Deocaris, Custer C.

    2006-01-01

    The regulation of tissue homeostasis in the gastrointestinal epithelium after epithelial injury focuses on the prostaglandins(PGs) as its major mediators. The two cyclooxygenase isoforms, cox-1 and cox-2, catalyze synthesis of PGs. Cox-1 is the predominant cyclooxygenase isoform found in the normal intestine. In contrast, cox-2 is present at low levels in normal intestine but is elevated at sites of inflammation, and in adenomas and carcinomas. To study the effects of various commercially-available cox-inhibitors (Ketorolac: cox-1 selective; Celecoxib: cox-2 selective; and Indocid: cox-1/2 non-selective), we determine mouse crypt epithelial cell fate after genotoxic injury with whole-body gamma-ray exposure at 15 Gy. Intestinal tissues of mice treated with cox-2 inhibitors that showed invariable apoptotic event, however, have increased occurrence of regenerating cells. Our results suggest a potential application of cox-2 selective inhibitors as radioprotective agent for normal cells after radiotherapy. (Author)

  3. Box-Cox transformation for QTL mapping.

    Science.gov (United States)

    Yang, Runqing; Yi, Nengjun; Xu, Shizhong

    2006-01-01

    The maximum likelihood method of QTL mapping assumes that the phenotypic values of a quantitative trait follow a normal distribution. If the assumption is violated, some forms of transformation should be taken to make the assumption approximately true. The Box-Cox transformation is a general transformation method which can be applied to many different types of data. The flexibility of the Box-Cox transformation is due to a variable, called transformation factor, appearing in the Box-Cox formula. We developed a maximum likelihood method that treats the transformation factor as an unknown parameter, which is estimated from the data simultaneously along with the QTL parameters. The method makes an objective choice of data transformation and thus can be applied to QTL analysis for many different types of data. Simulation studies show that (1) Box-Cox transformation can substantially increase the power of QTL detection; (2) Box-Cox transformation can replace some specialized transformation methods that are commonly used in QTL mapping; and (3) applying the Box-Cox transformation to data already normally distributed does not harm the result.

  4. Matérn thinned Cox processes

    DEFF Research Database (Denmark)

    Andersen, Ina Trolle; Hahn, Ute

    2016-01-01

    and hard core behaviour can be achieved by applying a dependent Matérn thinning to a Cox process. An exact formula for the intensity of a Matérn thinned shot noise Cox process is derived from the Palm distribution. For the more general class of Matérn thinned Cox processes, formulae for the intensity...

  5. Matérn thinned Cox processes

    DEFF Research Database (Denmark)

    Andersen, Ina Trolle; Hahn, Ute

    of clustering and hard core behaviour can be achieved by applying a dependent Matérn thinning to a Cox process. An exact formula for the intensity of a Matérn thinned shot noise Cox process is derived from the Palm distribution. For the more general class of Matérn thinned Cox processes, formulae...

  6. Advancing PubMed?

    DEFF Research Database (Denmark)

    Wildgaard, Lorna Elizabeth; Lund, Haakon

    2016-01-01

    the efficiency of biomedical literature searches. PubMed remains the primary resource for biomedical literature, and as PubMed makes the Medline data and Entrez PubMed Programming utilities freely available, any developer can produce alternative tools to search the database. The authors question if PubMed still...... provides the superior search interface for systematic searches or if the innovativeness of third-party tools provide alternatives worth considering. The paper aims to discuss these issues. Design/methodology/approach In all, 76 third-party tools that build on PubMed content were identified in a PubMed...... search and in published studies known to the authors. Only tools that provided free access to the broad PubMed content and designed specifically to enhance the search were included, reducing the set to 16 tools. The functionality of each tool within the scenario of a systematic search was compared across...

  7. Orange Book

    Data.gov (United States)

    U.S. Department of Health & Human Services — The Approved Drug Products with Therapeutic Equivalence (Orange Book or OB) is a list of drugs approved under Section 505 of the Federal Food, Drug and Cosmetic Act...

  8. Immunohistochemical and morphometric evaluation of COX 1 and COX-2 in the remodeled lung in idiopathic pulmonary fibrosis and systemic sclerosis

    Directory of Open Access Journals (Sweden)

    Edwin Roger Parra

    2013-12-01

    Full Text Available OBJECTIVE: To study the expression of COX-1 and COX-2 in the remodeled lung in systemic sclerosis (SSc and idiopathic pulmonary fibrosis (IPF patients, correlating that expression with patient survival.METHODS: We examined open lung biopsy specimens from 24 SSc patients and 30 IPF patients, using normal lung tissue as a control. The histological patterns included fibrotic nonspecific interstitial pneumonia (NSIP in SSc patients and usual interstitial pneumonia (UIP in IPF patients. We used immunohistochemistry and histomorphometry to evaluate the expression of COX-1 and COX-2 in alveolar septa, vessels, and bronchioles. We then correlated that expression with pulmonary function test results and evaluated its impact on patient survival.RESULTS: The expression of COX-1 and COX-2 in alveolar septa was significantly higher in IPF-UIP and SSc-NSIP lung tissue than in the control tissue. No difference was found between IPF-UIP and SSc-NSIP tissue regarding COX-1 and COX-2 expression. Multivariate analysis based on the Cox regression model showed that the factors associated with a low risk of death were younger age, high DLCO/alveolar volume, IPF, and high COX-1 expression in alveolar septa, whereas those associated with a high risk of death were advanced age, low DLCO/alveolar volume, SSc (with NSIP, and low COX-1 expression in alveolar septa.CONCLUSIONS: Our findings suggest that strategies aimed at preventing low COX-1 synthesis will have a greater impact on SSc, whereas those aimed at preventing high COX-2 synthesis will have a greater impact on IPF. However, prospective randomized clinical trials are needed in order to confirm that.

  9. Decomposition of variance for spatial Cox processes

    DEFF Research Database (Denmark)

    Jalilian, Abdollah; Guan, Yongtao; Waagepetersen, Rasmus

    Spatial Cox point processes is a natural framework for quantifying the various sources of variation governing the spatial distribution of rain forest trees. We introduce a general criterion for variance decomposition for spatial Cox processes and apply it to specific Cox process models...

  10. Decomposition of variance for spatial Cox processes

    DEFF Research Database (Denmark)

    Jalilian, Abdollah; Guan, Yongtao; Waagepetersen, Rasmus

    2013-01-01

    Spatial Cox point processes is a natural framework for quantifying the various sources of variation governing the spatial distribution of rain forest trees. We introduce a general criterion for variance decomposition for spatial Cox processes and apply it to specific Cox process models...

  11. PRof ILE of ORANGE CONSUMPTION AND CONSUMER ATTITUDES TO MINIMALLY PROCESSED ‘PERA’ ORANGE IN MUNICIPALITIES of THE STATE of SÃO PAULO

    Directory of Open Access Journals (Sweden)

    Maria Cecília de Arruda PALHARINI

    2012-08-01

    Full Text Available The objective of this work was to investigate the prof ile of orange consumption and consumer attitude to minimally processed orange. Seven hundred and seventeen questionnaires were applied in commercial establishments in three municipalities in the State of São Paulo, Brazil. Main results of this research are: orange is a highly appreciated fruit, being consumed in natura and also as its natural juice, moreover orange is purchased weekly at hypermarkets, the purchase intent for minimally processed orange was low and the likely consumers’ willingness of paying for that product would be near 200% over the ‘in natura’ fruit. Considering the high consume of ‘in natura’ orange and the increasing need for convenience and practicality, it is possible to affirm that there is a potential for commercializing minimally processed orange.

  12. Decomposition of variance for spatial Cox processes

    DEFF Research Database (Denmark)

    Jalilian, Abdollah; Guan, Yongtao; Waagepetersen, Rasmus

    Spatial Cox point processes is a natural framework for quantifying the various sources of variation governing the spatial distribution of rain forest trees. We introducea general criterion for variance decomposition for spatial Cox processes and apply it to specific Cox process models with additive...

  13. Inheritance of resistance to orange rust in sugarcane

    Science.gov (United States)

    Orange rust, caused by Puccinia kuehnii, is an economically important disease in the Florida sugarcane industry. In this study, orange rust reactions of seedlings in progenies originating from 12 crosses between female and male parents with differing resistance to orange rust (three of each categor...

  14. Radiolabeled COX-2 Inhibitors for Non-Invasive Visualization of COX-2 Expression and Activity — A Critical Update

    Directory of Open Access Journals (Sweden)

    Torsten Kniess

    2013-05-01

    Full Text Available Cyclooxygenase-2 (COX-2 is a key player in inflammation. Its overexpression is directly associated with various inflammatory diseases and, additionally, with several processes of carcinogenesis. The development of new selective COX-2 inhibitors (COXIBs for use in cancer treatment is in the focus of the medicinal chemistry research field. For this purpose, a set of methods is available to determine COX-2 expression and activity in vitro and ex vivo but it is still a problem to functionally characterize COX-2 in vivo. This review focusses on imaging agents targeting COX-2 which have been developed for positron emission tomography (PET and single photon emission computed tomography (SPECT since 2005. The literature reveals that different radiochemical methods are available to synthesize COXIBs radiolabeled with fluorine-18, carbon-11, and isotopes of radioiodine. Unfortunately, most of the compounds tested did not show sufficient stability in vivo due to de[18F]fluorination or de[11C]methylation or they failed to bind specifically in the target region. So, suitable stability in vivo, matching lipophilicity for the target compartment and both high affinity and selectivity for COX-2 were identified as prominent criteria for radiotracer development. Up to now, it is not clear what approach and which model is the most suited to evaluate COX-2 targeting imaging agents in vivo. However, for proof of principle it has been shown that some radiolabeled compounds can bind specifically in COX-2 overexpressing tissue which gives hope for future work in this field.

  15. Gruppemusikterapi med patienter med borderline-personlighedsforstyrrelse i dagbehandlingsregi

    DEFF Research Database (Denmark)

    Hannibal, Niels

    2008-01-01

    Denne artikel er første redegørelse for de erfaringer, som er gjort med gruppemusikterapi (GMT) for patienter med borderline-personlighedsforstyrrelse (BPF) i dagbehandlingsregi på Aalborg Psykiatriske Sygehus. Artiklen indeholder både konkrete anvisninger til aktiviteter og interventioner, liges...

  16. The Moxie of Kathy Cox

    Science.gov (United States)

    Johns, Stephanie

    2010-01-01

    Kathy Cox, the superintendent of schools for Georgia, believes "excellence is not an accident". She made a name for herself by winning $1 million proving she was smarter than a fifth-grader on a popular television show. This article presents a profile of Cox, her family, her role as school superintendent, and her accomplishments.…

  17. PubMedReco: A Real-Time Recommender System for PubMed Citations.

    Science.gov (United States)

    Samuel, Hamman W; Zaïane, Osmar R

    2017-01-01

    We present a recommender system, PubMedReco, for real-time suggestions of medical articles from PubMed, a database of over 23 million medical citations. PubMedReco can recommend medical article citations while users are conversing in a synchronous communication environment such as a chat room. Normally, users would have to leave their chat interface to open a new web browser window, and formulate an appropriate search query to retrieve relevant results. PubMedReco automatically generates the search query and shows relevant citations within the same integrated user interface. PubMedReco analyzes relevant keywords associated with the conversation and uses them to search for relevant citations using the PubMed E-utilities programming interface. Our contributions include improvements to the user experience for searching PubMed from within health forums and chat rooms, and a machine learning model for identifying relevant keywords. We demonstrate the feasibility of PubMedReco using BMJ's Doc2Doc forum discussions.

  18. Recovery of aroma compounds from orange essential oil

    Directory of Open Access Journals (Sweden)

    Haypek E.

    2000-01-01

    Full Text Available The objective of this work was to study the recovery of aroma compounds present in the orange essential oil using experimental data from CUTRALE (a Brazilian Industry of Concentrated Orange Juice. The intention was to reproduce the industrial unit and afterwards to optimize the recovery of aroma compounds from orange essential oil by liquid-liquid extraction. The orange oil deterpenation was simulated using the commercial software PRO/II 4.0 version 1.0. The UNIFAC model was chosen for the calculation of the activity coefficients.

  19. LC-MS/MS confirms that COX-1 drives vascular prostacyclin whilst gene expression pattern reveals non-vascular sites of COX-2 expression.

    Directory of Open Access Journals (Sweden)

    Nicholas S Kirkby

    Full Text Available There are two schools of thought regarding the cyclooxygenase (COX isoform active in the vasculature. Using urinary prostacyclin markers some groups have proposed that vascular COX-2 drives prostacyclin release. In contrast, we and others have found that COX-1, not COX-2, is responsible for vascular prostacyclin production. Our experiments have relied on immunoassays to detect the prostacyclin breakdown product, 6-keto-PGF1α and antibodies to detect COX-2 protein. Whilst these are standard approaches, used by many laboratories, antibody-based techniques are inherently indirect and have been criticized as limiting the conclusions that can be drawn. To address this question, we measured production of prostanoids, including 6-keto-PGF1α, by isolated vessels and in the circulation in vivo using liquid chromatography tandem mass spectrometry and found values essentially identical to those obtained by immunoassay. In addition, we determined expression from the Cox2 gene using a knockin reporter mouse in which luciferase activity reflects Cox2 gene expression. Using this we confirm the aorta to be essentially devoid of Cox2 driven expression. In contrast, thymus, renal medulla, and regions of the brain and gut expressed substantial levels of luciferase activity, which correlated well with COX-2-dependent prostanoid production. These data are consistent with the conclusion that COX-1 drives vascular prostacyclin release and puts the sparse expression of Cox2 in the vasculature in the context of the rest of the body. In doing so, we have identified the thymus, gut, brain and other tissues as target organs for consideration in developing a new understanding of how COX-2 protects the cardiovascular system.

  20. 7 CFR 29.1043 - Orange (F).

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 2 2010-01-01 2010-01-01 false Orange (F). 29.1043 Section 29.1043 Agriculture Regulations of the Department of Agriculture AGRICULTURAL MARKETING SERVICE (Standards, Inspections, Marketing... Type 92) § 29.1043 Orange (F). A reddish yellow. [42 FR 21092, Apr. 25, 1977. Redesignated at 47 FR...

  1. Hybrid white organic light-emitting devices based on phosphorescent iridium-benzotriazole orange-red and fluorescent blue emitters

    Energy Technology Data Exchange (ETDEWEB)

    Xia, Zhen-Yuan, E-mail: xiazhenyuan@hotmail.com [Key Laboratory for Advanced Materials and Institute of Fine Chemicals, East China University of Science and Technology, Shanghai 200237 (China); Su, Jian-Hua [Key Laboratory for Advanced Materials and Institute of Fine Chemicals, East China University of Science and Technology, Shanghai 200237 (China); Chang, Chi-Sheng; Chen, Chin H. [Display Institute, Microelectronics and Information Systems Research Center, National Chiao Tung University, Hsinchu, Taiwan 300 (China)

    2013-03-15

    We demonstrate that high color purity or efficiency hybrid white organic light-emitting devices (OLEDs) can be generated by integrating a phosphorescent orange-red emitter, bis[4-(2H-benzotriazol-2-yl)-N,N-diphenyl-aniline-N{sup 1},C{sup 3}] iridium acetylacetonate, Ir(TBT){sub 2}(acac) with fluorescent blue emitters in two different emissive layers. The device based on deep blue fluorescent material diphenyl-[4-(2-[1,1 Prime ;4 Prime ,1 Double-Prime ]terphenyl-4-yl-vinyl)-phenyl]-amine BpSAB and Ir(TBT){sub 2}(acac) shows pure white color with the Commission Internationale de L'Eclairage (CIE) coordinates of (0.33,0.30). When using sky-blue fluorescent dopant N,N Prime -(4,4 Prime -(1E,1 Prime E)-2,2 Prime -(1,4-phenylene)bis(ethene-2,1-diyl) bis(4,1-phenylene))bis(2-ethyl-6-methyl-N-phenylaniline) (BUBD-1) and orange-red phosphor with a color-tuning phosphorescent material fac-tris(2-phenylpyridine) iridium (Ir(ppy){sub 3} ), it exhibits peak luminance yield and power efficiency of 17.4 cd/A and 10.7 lm/W, respectively with yellow-white color and CIE color rendering index (CRI) value of 73. - Highlights: Black-Right-Pointing-Pointer An iridium-based orange-red phosphor Ir(TBT){sub 2}(acac) was applied in hybrid white OLEDs. Black-Right-Pointing-Pointer Duel- and tri-emitter WOLEDs were achieved with either high color purity or efficiency performance. Black-Right-Pointing-Pointer Peak luminance yield of tri-emitter WOLEDs was 17.4 cd/A with yellow-white color and color rendering index (CRI) value of 73.

  2. Female guppies use orange as choice cue: a manipulative test ...

    African Journals Online (AJOL)

    Female guppies from a feral South African population respond sexually to more orange males in correlative trials. We impaired the female's ability to use orange elements of male colour patterns by conducting choice trials under orange light. Under orange light, there was no relationship between male colour pattern and ...

  3. An overview on the Brazilian orange juice production chain

    OpenAIRE

    Renato Marcio dos Santos; Irenilza de Alencar Nääs; Mario Mollo Neto; Oduvaldo Vendrametto

    2013-01-01

    Brazil is the world's largest producer of oranges and uses more than 70% of the harvested fruits in the production of juices. The amount of processed orange is growing about 10% per year, confirming the trend of the Brazilian citrus for juice production. This research aimed to investigate the Brazilian orange juice production chain from 2005 to 2009. Data from the amount of frozen juice produced and exported, international price of orange juice, and intermediate transactions were assessed in ...

  4. Colorful and transparent poly(vinyl alcohol) composite films filled with layered zinc hydroxide salts, intercalated with anionic orange azo dyes (methyl orange and orange II)

    International Nuclear Information System (INIS)

    Neves da Silva, Marlon Luiz; Marangoni, Rafael; Cursino, Ana Cristina Trindade; Schreiner, Wido Herwig; Wypych, Fernando

    2012-01-01

    Highlights: ► Zinc hydroxide salts were successfully intercalated with anionic orange azo dyes. ► The anionic dye was co-intercalated with hydrated chloride anions. ► The orange materials were used as fillers for poly(vinyl alcohol). ► Transparent, homogeneous, colorful PVA films were obtained by wet casting. ► Some composites stored at lower humidity exhibited improved mechanical properties. - Abstract: Layered zinc hydroxide salts (zinc LHS) were intercalated with anionic orange azo dyes, namely methyl orange (MO) and orange II (OII), and co-intercalated with hydrated chloride anions. After characterization by X-ray diffraction (XRD), thermal analysis (TGA/DTA), Fourier transform infrared spectroscopy (FTIR), and X-ray photoelectron spectroscopy (XPS), the materials were used as fillers for poly(vinyl alcohol) (PVA). Colorful transparent films were obtained by wet casting, revealing good dispersion of the material into the polymer. In the case of zinc LHS/OII, PVA was intercalated between the zinc LHS layers. Evaluation of the mechanical properties of the PVA composite films revealed that the layered colorful materials were able to increase the mechanical properties of the PVA films only when the films were stored under lower relative humidity. As expected, films with higher water content displayed reduced tensile strength and modulus because of the plasticizing effect of water. As for the films stored at 43% relative humidity, more pronounced improvement of modulus was observed for 1 and 4% zinc LHS/OII, and enhanced tensile strength was achieved for 0.5 and 1% zinc LHS/OII. This effect can be attributed to better dispersion of the layered filler and its better adhesion to the PVA matrix.

  5. Orange County Photovoltaic Project & Educational COmponent

    Energy Technology Data Exchange (ETDEWEB)

    Parker, Renee [Orange County Government, FL (United States)

    2016-02-12

    The purpose of this report is to discuss the projects implemented, utilizing Department of Energy grant funds, to support the use and understanding of renewable energy in Orange County, Florida and the Greater Orlando Area. Orange County is located in the State of Florida and is most popularly referred to as Orlando. The greater Orlando area’s current population is 1,225,267 and in 2015 was the first destination to surpass 60 million visitors. Orange County utilized grant funds to add to the growing demand for access to charging stations by installing one level 2 dual NovaCharge CT4021 electric vehicle charging station at the Orange County/University of Florida Cooperative Extension Center. The charging station is considered a “smart” charger connected to a central network operated by a third party. Data collected includes the number of charging sessions, session start and end times, the electricity usage, greenhouse gases saved and other pertinent data used for reporting purposes. Orange County continues to support the use of electric vehicles in Metro Orlando and this project continues to bring awareness to our public regarding using alternative vehicles. Additionally, we offer all visitors to the Orange County/University of Florida Cooperative Extension Center free charges for their electric vehicles 24 hours a day. Since the operation of the charging station there have been 52 unique driver users, a total of 532.2258 kg of greenhouse gas savings and 159.03 gallons of gasoline savings. The installation of the additional electric vehicle charging station is part of a county-wide goal of promoting implementation of renewable energy technologies as well as supporting the use of electric vehicles including the Drive Electric Orlando & Florida programs. http://driveelectricorlando.com/ & ; http://www.driveelectricflorida.org/ . Grant funds were also used for Outreach and Educational efforts. Educational efforts about renewable energy were accomplished through

  6. Single cell protein from mandarin orange peel

    Energy Technology Data Exchange (ETDEWEB)

    Mishio, M.; Magai, J.

    1981-01-01

    As the hydrolysis of mandarin orange peel with macerating enzyme (40 degrees C, 24 h) produced 0.59 g g-1 reducing sugar per dry peel compared to 0.36 by acid-hydrolysis (15 min at 120 degrees C with 0.8 N H2S04), the production of single cell protein (SCP) from orange peel was studied mostly using enzymatically hydrolyzed orange peel. When the enzymatically hydrolyzed peel media were used, the utilization efficiency of reducing sugars (%) and the growth yield from reducing sugars (g g-1) were: 63 and 0.51 for Saccharomyces cerevisiae; 56 and 0.48 for Candida utilis; 74 and 0.69 for Debaryomyces hansenii and 64 and 0.70 for Rhodotorula glutinis. SCP production from orange peel by D. hansenii and R. glutinis were further studied. Batch cultures for 24 h at 30 degrees C using 100g dried orange peel produced 45 g of dried cultivated peel (protein content, 33%) with D. hansenii and 34 g (protein content, 50%) with R. glutinis, and 38 g (protein content, 44%) with a mixture of both yeasts. (Refs. 12).

  7. 21 CFR 146.154 - Concentrated orange juice with preservative.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 2 2010-04-01 2010-04-01 false Concentrated orange juice with preservative. 146... Canned Fruit Juices and Beverages § 146.154 Concentrated orange juice with preservative. (a) Concentrated orange juice with preservative complies with the requirements for composition and labeling of optional...

  8. Studi Kasus Ketidakpatuhan Orang Kontak Serumah terhadap Anjuran Pemeriksaan Tuberkulosis

    Directory of Open Access Journals (Sweden)

    Rovina Ruslam

    2017-08-01

    Full Text Available Ketidakpatuhan orang kontak serumah terhadap anjuran pemeriksaan Tuberkulosis (TB merupakan fenomena kompleks, dinamis dari faktor yang berkaitan dengan perilaku. Penelitian ini bertujuan untuk menggali perilaku ketidakpatuhan orang kontak serumah terhadap anjuran pemeriksaan TB dengan menggunakan Health Belief Model (HBM. Penelitian ini adalah studi kasus yang dilakukan di Kelurahan Pajajaran Kota Bandung. Subjek penelitian adalah sembilan orang kontak serumah dan enam orang perawat Puskesmas Pasirkaliki. Pengumpulan data dilakukan dengan studi dokumentasi, observasi pasif tidak berstruktur, wawancara mendalam, dan diskusi kelompok terarah. Data dianalisis dengan menggunakan model Miles dan Huberman, yaitu reduksi data, penyajian data, dan penarikan kesimpulan. Hasil penelitian meliputi persepsi kerentanan, persepsi keseriusan, persepsi manfaat pemeriksaan orang kontak serumah, dan isyarat untuk melakukan tindakan berdasarkan HBM. Persepsi orang kontak serumah tentang kerentanan TB meliputi adanya perasaan takut tertular, melakukan pemisahan, dan menerima takdir. Persepsi orang kontak serumah mengenai keseriusan penyakit TB yaitu kematian, perasaan malu atau minder. Persepsi orang kontak serumah tentang manfaat skrining yaitu akan diketahui apakah orang kontak serumah terkena TB atau tidak. Isyarat untuk melakukan tindakan pemeriksaan TB menurut orang kontak serumah yaitu apabila mereka sudah sakit atau muncul gejala-gejala TB. Hasil penelitian dari perawat menunjukkan bahwa perawat mengetahui bahwa salah satu standar program penanggulangan TB (P2TB adalah pemeriksaan TB pada orang kontak serumah penderita TB paru terutama yang basil tahan asam (BTA positif dan anak dengan TB. Pemeriksaan TB tersebut dilakukan dengan pemeriksaan dahak sewaktu-pagi-sewaktu (SPS. Persepsi perawat mengenai hambatan dalam menjalankan peran dan fungsinya yaitu adanya keterbatasan jumlah tenaga di puskesmas, pendidikan perawat masih rendah, dan perawat mendapat tugas

  9. Diagnosis checking of statistical analysis in RCTs indexed in PubMed.

    Science.gov (United States)

    Lee, Paul H; Tse, Andy C Y

    2017-11-01

    Statistical analysis is essential for reporting of the results of randomized controlled trials (RCTs), as well as evaluating their effectiveness. However, the validity of a statistical analysis also depends on whether the assumptions of that analysis are valid. To review all RCTs published in journals indexed in PubMed during December 2014 to provide a complete picture of how RCTs handle assumptions of statistical analysis. We reviewed all RCTs published in December 2014 that appeared in journals indexed in PubMed using the Cochrane highly sensitive search strategy. The 2014 impact factors of the journals were used as proxies for their quality. The type of statistical analysis used and whether the assumptions of the analysis were tested were reviewed. In total, 451 papers were included. Of the 278 papers that reported a crude analysis for the primary outcomes, 31 (27·2%) reported whether the outcome was normally distributed. Of the 172 papers that reported an adjusted analysis for the primary outcomes, diagnosis checking was rarely conducted, with only 20%, 8·6% and 7% checked for generalized linear model, Cox proportional hazard model and multilevel model, respectively. Study characteristics (study type, drug trial, funding sources, journal type and endorsement of CONSORT guidelines) were not associated with the reporting of diagnosis checking. The diagnosis of statistical analyses in RCTs published in PubMed-indexed journals was usually absent. Journals should provide guidelines about the reporting of a diagnosis of assumptions. © 2017 Stichting European Society for Clinical Investigation Journal Foundation.

  10. An Additive-Multiplicative Cox-Aalen Regression Model

    DEFF Research Database (Denmark)

    Scheike, Thomas H.; Zhang, Mei-Jie

    2002-01-01

    Aalen model; additive risk model; counting processes; Cox regression; survival analysis; time-varying effects......Aalen model; additive risk model; counting processes; Cox regression; survival analysis; time-varying effects...

  11. Identification of sulfur volatiles in canned orange juices lacking orange flavor.

    Science.gov (United States)

    Perez-Cacho, Pilar Ruiz; Mahattanatawee, Kanjana; Smoot, John M; Rouseff, Russell

    2007-07-11

    The purpose of this study was to understand why some canned orange juices are not perceived as orange juice. Sensory flavor profile data indicated that the primary odor (orthonasal) attributes were tropical fruit/grapefruit, cooked/caramel, musty, and medicine. By comparison fresh-squeezed juice lacked these odor attributes. GC-O analysis found 43 odor-active components in canned juices. Eight of these aroma volatiles were sulfur based. Four of the 12 most intense aroma peaks were sulfur compounds that included methanethiol, 1-p-menth-1-ene-8-thiol, 2-methyl-3-furanthiol, and dimethyl trisulfide. The other most intense odorants included 7-methyl-3-methylene-1,6-octadiene (myrcene), octanal, 2-methoxyphenol (guaiacol), 2-ethyl-4-hydroxy-5-methyl-3(2H)-furanone (homofuraneol), (E)-non-2-enal, (E,E)-deca-2,4-dienal, 4-hydroxy-3-methoxybenzaldehyde (vanillin), and alpha-sinensal. Odorants probably responsible for the undesirable sensory attributes included grapefruit (1-p-menth-1-ene-8-thiol), cooked [2-ethyl-4-hydroxy-5-methyl-3(2H)-furanone, 4-hydroxy-2,5-dimethyl-3(2H)-furanone (Furaneol), and 3-(methylthio)propanal (methional)], musty [7-methyl-3-methylene-1,6-octadiene and (E)-non-2-enal], and medicine (2-methoxyphenol). The canned juices also lacked several aldehydes and esters normally found in fresh orange juice.

  12. Molecular basis of cyclooxygenase enzymes (COXs) selective inhibition

    Science.gov (United States)

    Limongelli, Vittorio; Bonomi, Massimiliano; Marinelli, Luciana; Gervasio, Francesco Luigi; Cavalli, Andrea; Novellino, Ettore; Parrinello, Michele

    2010-01-01

    The widely used nonsteroidal anti-inflammatory drugs block the cyclooxygenase enzymes (COXs) and are clinically used for the treatment of inflammation, pain, and cancers. A selective inhibition of the different isoforms, particularly COX-2, is desirable, and consequently a deeper understanding of the molecular basis of selective inhibition is of great demand. Using an advanced computational technique we have simulated the full dissociation process of a highly potent and selective inhibitor, SC-558, in both COX-1 and COX-2. We have found a previously unreported alternative binding mode in COX-2 explaining the time-dependent inhibition exhibited by this class of inhibitors and consequently their long residence time inside this isoform. Our metadynamics-based approach allows us to illuminate the highly dynamical character of the ligand/protein recognition process, thus explaining a wealth of experimental data and paving the way to an innovative strategy for designing new COX inhibitors with tuned selectivity. PMID:20215464

  13. COX-2 and p53 in human sinonasal cancer

    DEFF Research Database (Denmark)

    Holmila, Reetta; Cyr, Diane; Luce, Danièle

    2008-01-01

    The causal role of wood-dust exposure in sinonasal cancer (SNC) has been established in epidemiological studies, but the mechanisms of SNC carcinogenesis are still largely unknown. Increased amounts of COX-2 are found in both premalignant and malignant tissues, and experimental evidence link COX-2...... to development of cancer. Many signals that activate COX-2 also induce tumor suppressor p53, a transcription factor central in cellular stress response. We investigated COX-2 and p53 expressions by immunohistochemistry in 50 SNCs (23 adenocarcinomas, and 27 squamous cell carcinomas (SCC); 48 analyzed for COX-2...... displayed adenocarcinoma. COX-2 was expressed at higher levels in adenocarcinoma as compared to SSC (p COX-2 expression showed significant association with occupational exposure to wood dust (p = 0.024), and with nonsmoking status (p = 0.001). No statistically significant associations between...

  14. Exploring QSAR with E-state index: selectivity requirements for COX-2 versus COX-1 binding of terphenyl methyl sulfones and sulfonamides.

    Science.gov (United States)

    Chakraborty, Santanu; Sengupta, Chandana; Roy, Kunal

    2004-09-20

    An attempt has been made to explore selectivity requirements for cyclooxygenase-2 (COX-2) versus cyclooxygenase-1 (COX-1) binding of terphenyl methyl sulfones and sulfonamides using electrotopological state (E-state) index and suitable indicator parameters. Multiple linear regression analyses produced statistically acceptable equations: the best relation based on 'all-possible-subsets regression' for COX-1 binding (n=18) showed predicted variance and explained variance of 0.675 and 0.777, respectively, while in case of the best equation for COX-2 binding (n=38), these values rose to 0.842 and 0.874, respectively. For the selectivity relation (n=17), predicted variance and explained variance values were 0.601 and 0.687, respectively. Based on the results of the analyses, three important sites have been suggested: sites A (methylsulfonyl or aminosulfonyl moiety), B (central phenyl ring), and C (terminal phenyl ring containing different substituents). All three sites are important for COX-2 binding while sites B and C are important for COX-1 binding. For COX-2 selectivity, only site C plays an important role. The study shows the utility of E-state index in developing statistically acceptable model having direct physicochemical significance.

  15. Estimating functions for inhomogeneous Cox processes

    DEFF Research Database (Denmark)

    Waagepetersen, Rasmus

    2006-01-01

    Estimation methods are reviewed for inhomogeneous Cox processes with tractable first and second order properties. We illustrate the various suggestions by means of data examples.......Estimation methods are reviewed for inhomogeneous Cox processes with tractable first and second order properties. We illustrate the various suggestions by means of data examples....

  16. Musikterapi med børn med svær autisme - en litteraturgennemgang

    Directory of Open Access Journals (Sweden)

    Ulla Holck

    2003-03-01

    Full Text Available Faglitteratur om musikterapi med børn med autisme er omfattende og indeholder såvel kvalitative case-beskrivelser som kvantitative forskningsundersøgelser. I artiklen gennemgås faglitteraturen systematisk med henblik på at specifi cere musikterapiens effekt og virkemåder i forhold til denne målgruppe. Vægten ligger på børn med svær autisme, men litteratur om voksne højtfungerende personer med autisme inddrages også. Forskningslitteraturen viser, at det især er inden for områderne koncentration, visuel opmærksomhed, respons og initiativ, samt brug af stemme og tur-tagning, at musikterapi har en effekt. Case-litteraturen begrunder denne effekt med musikkens evne til at være redundant, anvendelse af imitation og responsfremmende teknikker (overraskelse etc., fælles opbyggede samspilsformer, samt det temporale-interaktive element i improvisatorisk musikterapi. Ud fra en interaktionsteoretisk indfaldsvinkel sammenkobles effekten endvidere med, at den musikalske interaktion hjælper musikterapeuten til at fastholde et dynamisk udtryk, hvilket er afgørende i forhold til en klientgruppe, der ofte giver ´flad´ eller stærkt afvigende feedback.

  17. Nostalgitrip med Pikachu

    DEFF Research Database (Denmark)

    Konzack, Lars

    2016-01-01

    Sommeren 2016 vil blive husket for den omsiggribende dille, Pokémon Go, med over 100 millioner downloads. Tusindvis af især børn og unge, men også forældre med barnevogne og hele familier, kunne pludselig ses på gader og stræder, i parker og grønne områder med en smartphone i hånden på jagt efter...

  18. Endurance exercise after orange ingestion anaphylaxis

    Directory of Open Access Journals (Sweden)

    Manu Gupta

    2016-01-01

    Full Text Available Endurance exercise after orange ingestion cause anaphylaxis which is food-dependent exercise-induced anaphylaxis (FDEIA which is a form of exercise-induced anaphylaxis. In this article, an individual develops symptoms such as flushing, itching, urticaria, angioedema, and wheezing after eating a food allergen and proceeds to exercise. Neither the food alone nor exercise alone is sufficient to induce a reaction. This case report describes a 36-year-old asthmatic male athlete who experienced nausea, vomiting, flushing, urticaria, and facial swelling while exercising in a gymnasium after eating oranges. Neither oranges alone nor exercise alone induced the reaction. Total avoidance of suspected food allergens would be ideal. Persons with FDEIA should keep at hand an emergency kit with antihistamines, injectable rapid action corticoids, and adrenaline.

  19. Orange County Government Solar Demonstration and Research Facility

    Energy Technology Data Exchange (ETDEWEB)

    Parker, Renee [Orange County Florida, Orlando, Florida (United States); Cunniff, Lori [Orange County Florida, Orlando, Florida (United States)

    2015-05-12

    Orange County Florida completed the construction of a 20 kilowatt Solar Demonstration and Research Facility in March 2015. The system was constructed at the Orange County/University of Florida Cooperative Extension Center whose electric service address is 6021 South Conway Road, Orlando, Florida 32802. The Solar Demonstration and Research Facility is comprised of 72 polycrystalline photovoltaic modules and 3 inverters which convert direct current from the solar panels to alternating current electricity. Each module produces 270 watts of direct current power, for a total canopy production of just under 20,000 watts. The solar modules were installed with a fixed tilt of 5 degrees and face south, toward the equator to maximize the amount of sunlight captures. Each year, the electricity generated by the solar array will help eliminate 20 metric tons of carbon dioxide emissions as well as provide covered parking for staff and visitors vehicles. The solar array is expected to generate 27,000 kilowatt hours of electricity annually equating to an estimated $266 savings in the monthly electric bill, or $3,180 annually for the Orange County/University of Florida Cooperative Extension Center. In addition to reducing the electric bill for the Extension Center, Orange County’s solar array also takes advantage of a rebate incentive offered by the local utility, Orlando Utility Commission, which provided a meter that measures the amount of power produced by the solar array. The local utility company’s Solar Photovoltaic Production Incentive will pay Orange County $0.05 per kilowatt hour for the power that is produced by the solar array. This incentive is provided in addition to Net Metering benefits, which is an effort to promote the use of clean, renewable energy on the electric grid. The Photovoltaic Solar Demonstration and Research Facility also serves an educational tool to the public; the solar array is tied directly into a data logger that provides real time power

  20. The cardiac copper chaperone proteins Sco1 and CCS are up-regulated, but Cox 1 and Cox4 are down-regulated, by copper deficiency.

    Science.gov (United States)

    Getz, Jean; Lin, Dingbo; Medeiros, Denis M

    2011-10-01

    Copper is ferried in a cell complexed to chaperone proteins, and in the heart much copper is required for cytochrome c oxidase (Cox). It is not completely understood how copper status affects the levels of these proteins. Here we determined if dietary copper deficiency could up- or down-regulate select copper chaperone proteins and Cox subunits 1 and 4 in cardiac tissue of rats. Sixteen weanling male Long-Evans rats were randomized into treatment groups, one group receiving a copper-deficient diet (CCS, Sco1, Ctr1, Cox17, Cox1, and Cox4 by SDS-PAGE and Western blotting. No changes were observed in the concentrations of CTR1 and Cox17 between copper-adequate and copper-deficient rats. CCS and Sco1 were up-regulated and Cox1 and Cox4 were both down-regulated as a result of copper deficiency. These data suggest that select chaperone proteins and may be up-regulated, and Cox1 and 4 down-regulated, by a dietary copper deficiency, whereas others appear not to be affected by copper status.

  1. Neutron activation analysis of thin orange pottery

    International Nuclear Information System (INIS)

    Harbottle, G.; Sayre, E.V.; Abascal, R.

    1976-01-01

    The evidence thus far obtained supports the idea of ''Thin Orange'' ware, typical of classic Teotihuacan culture, easily identifiable petrographically or chemically, not necessarily made at Teotihuacan itself but widely traded, and ''thin, orange'' pottery, fabricated in many other places, and perhaps at other times as well

  2. Neutron activation analysis of thin orange pottery

    Energy Technology Data Exchange (ETDEWEB)

    Harbottle, G; Sayre, E V; Abascal, R

    1976-01-01

    The evidence thus far obtained supports the idea of ''Thin Orange'' ware, typical of classic Teotihuacan culture, easily identifiable petrographically or chemically, not necessarily made at Teotihuacan itself but widely traded, and ''thin, orange'' pottery, fabricated in many other places, and perhaps at other times as well.

  3. Interview med børn

    DEFF Research Database (Denmark)

    Interview med børn handler om børneinterview i forbindelse med forskning. Bogen er tænkt som inspiration til og afsæt for metodiske refleksioner i forbindelse med inddragelse af børn som informanter.......Interview med børn handler om børneinterview i forbindelse med forskning. Bogen er tænkt som inspiration til og afsæt for metodiske refleksioner i forbindelse med inddragelse af børn som informanter....

  4. 21 CFR 82.1260 - D&C Orange No. 10.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 1 2010-04-01 2010-04-01 false D&C Orange No. 10. 82.1260 Section 82.1260 Food... CERTIFIED PROVISIONALLY LISTED COLORS AND SPECIFICATIONS Drugs and Cosmetics § 82.1260 D&C Orange No. 10. The color additive D&C Orange No. 10 shall conform in identity and specifications to the requirements...

  5. 21 CFR 74.2255 - D&C Orange No. 5.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 1 2010-04-01 2010-04-01 false D&C Orange No. 5. 74.2255 Section 74.2255 Food and... ADDITIVES SUBJECT TO CERTIFICATION Cosmetics § 74.2255 D&C Orange No. 5. (a) Identity and specifications. The color additive D&C Orange No. 5 shall conform in identity and specifications to the requirements...

  6. 21 CFR 74.2254 - D&C Orange No. 4.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 1 2010-04-01 2010-04-01 false D&C Orange No. 4. 74.2254 Section 74.2254 Food and... ADDITIVES SUBJECT TO CERTIFICATION Cosmetics § 74.2254 D&C Orange No. 4. (a) Identity and specifications. The color additive D&C Orange No. 4 shall conform in identity and specifications to the requirements...

  7. 21 CFR 82.1261 - D&C Orange No. 11.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 1 2010-04-01 2010-04-01 false D&C Orange No. 11. 82.1261 Section 82.1261 Food... CERTIFIED PROVISIONALLY LISTED COLORS AND SPECIFICATIONS Drugs and Cosmetics § 82.1261 D&C Orange No. 11. The color additive D&C Orange No. 11 shall conform in identity and specifications to the requirements...

  8. 21 CFR 73.3112 - C.I. Vat Orange 1.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 1 2010-04-01 2010-04-01 false C.I. Vat Orange 1. 73.3112 Section 73.3112 Food... COLOR ADDITIVES EXEMPT FROM CERTIFICATION Medical Devices § 73.3112 C.I. Vat Orange 1. (a) Identity. The color additive is C.I. Vat Orange 1, Colour Index No. 59105. (b) Uses and restrictions. (1) The...

  9. 21 CFR 74.2260 - D&C Orange No. 10.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 1 2010-04-01 2010-04-01 false D&C Orange No. 10. 74.2260 Section 74.2260 Food... COLOR ADDITIVES SUBJECT TO CERTIFICATION Cosmetics § 74.2260 D&C Orange No. 10. (a) Identity and specifications. The color additive D&C Orange No. 10 shall conform in identity and specifications to the...

  10. 21 CFR 74.2261 - D&C Orange No. 11.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 1 2010-04-01 2010-04-01 false D&C Orange No. 11. 74.2261 Section 74.2261 Food... COLOR ADDITIVES SUBJECT TO CERTIFICATION Cosmetics § 74.2261 D&C Orange No. 11. (a) Identity and specifications. The color additive D&C Orange No. 11 shall conform in identity and specifications to the...

  11. Virtuelt skrivebord med open office

    DEFF Research Database (Denmark)

    Nielsen, Kurt Gammelgaard

    2009-01-01

    SDUs erfaringer med projektet Port 22: en virtuel platform med Open Office som kontorpakke til studerende.......SDUs erfaringer med projektet Port 22: en virtuel platform med Open Office som kontorpakke til studerende....

  12. Mediator Complex Subunits MED2, MED5, MED16, and MED23 Genetically Interact in the Regulation of Phenylpropanoid Biosynthesis.

    Science.gov (United States)

    Dolan, Whitney L; Dilkes, Brian P; Stout, Jake M; Bonawitz, Nicholas D; Chapple, Clint

    2017-12-01

    The phenylpropanoid pathway is a major global carbon sink and is important for plant fitness and the engineering of bioenergy feedstocks. In Arabidopsis thaliana , disruption of two subunits of the transcriptional regulatory Mediator complex, MED5a and MED5b, results in an increase in phenylpropanoid accumulation. By contrast, the semidominant MED5b mutation reduced epidermal fluorescence4-3 ( ref4-3 ) results in dwarfism and constitutively repressed phenylpropanoid accumulation. Here, we report the results of a forward genetic screen for suppressors of ref4-3. We identified 13 independent lines that restore growth and/or phenylpropanoid accumulation in the ref4-3 background. Two of the suppressors restore growth without restoring soluble phenylpropanoid accumulation, indicating that the growth and metabolic phenotypes of the ref4-3 mutant can be genetically disentangled. Whole-genome sequencing revealed that all but one of the suppressors carry mutations in MED5b or other Mediator subunits. RNA-seq analysis showed that the ref4-3 mutation causes widespread changes in gene expression, including the upregulation of negative regulators of the phenylpropanoid pathway, and that the suppressors reverse many of these changes. Together, our data highlight the interdependence of individual Mediator subunits and provide greater insight into the transcriptional regulation of phenylpropanoid biosynthesis by the Mediator complex. © 2017 American Society of Plant Biologists. All rights reserved.

  13. Vocal behaviour of Orange River Francolin Scleroptila ...

    African Journals Online (AJOL)

    Fieldwork to study the vocal behaviour of Orange River Francolin Scleroptilia levaillantoides was conducted on a farm in the Heidelberg district, Gauteng province, South Africa, during August 2009 to March 2011. Orange River Francolins possess a basic repertoire of seven calls and one mechanical sound. From 83 ...

  14. Studi Komunikasi Antarpribadi Anak Dengan Orang Tua Tiri

    Directory of Open Access Journals (Sweden)

    Chaterine Setiawan

    2017-07-01

    Full Text Available This study discusses the communication between the child and the stepparent and use the theory that consists of communication theory, communication function, the purpose of communication, interpersonal communication, effective interpersonal communication, interpersonal communication role and function of interpersonal communication. This study used a qualitative method with descriptive qualitative approach. The data used in this study consisted of primary data and secondary data. The primary data of the interviews with sources consisting of four children and one stepparent. While the secondary data obtained from other sources such as books and online data searches. The technique of collecting data using interviews, observation, literature review and data searches online. From this research it is known that children who learn about and understand the prospective stepparent before she married biological parents do relatively better than those who do not recognize his step prospective parents before marriage. It is also known that the interpersonal communication of children with stepparents dependent based on the character of the child and the stepparent respectively. Penelitian ini membahas tentang komunikasi antara anak dengan orang tua tiri dan menggunakan teori yang terdiri dari teori komunikasi, fungsi komunikasi, tujuan komunikasi, komunikasi antarpribadi, komunikasi antarpribadi yang efektif, peranan komunikasi antarpribadi dan fungsi komunikasi antarpribadi. Penelitian ini menggunakan metode kualitatif dengan pendekatan deskriptif kualitatif. Data yang digunakan dalam penelitian ini terdiri dari data primer dan data sekunder. Data primer berupa hasil wawancara dengan narasumber yang terdiri dari empat orang anak dan satu orang tua tiri. Sedangkan data sekunder berupa data yang diperoleh dari buku dan sumber lain seperti penelusuran data online. Teknik pengumpulan data dengan menggunakan wawancara, observasi, kajian pustaka dan penelusuran

  15. 21 CFR 74.1261 - D&C Orange No. 11.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 1 2010-04-01 2010-04-01 false D&C Orange No. 11. 74.1261 Section 74.1261 Food... COLOR ADDITIVES SUBJECT TO CERTIFICATION Drugs § 74.1261 D&C Orange No. 11. (a) Identity. (1) The color additive D&C Orange No. 11 is a mixture consisting principally of the disodium salts of 4′,5...

  16. 21 CFR 74.1254 - D&C Orange No. 4.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 1 2010-04-01 2010-04-01 false D&C Orange No. 4. 74.1254 Section 74.1254 Food and... ADDITIVES SUBJECT TO CERTIFICATION Drugs § 74.1254 D&C Orange No. 4. (a) Identity. (1) the color additive D&C Orange No. 4 is principally the sodium salt of 4-[(2-hydroxy-1-naphthalenyl)azo]benzenesulfonic...

  17. 21 CFR 82.1255 - D&C Orange No. 5.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 1 2010-04-01 2010-04-01 false D&C Orange No. 5. 82.1255 Section 82.1255 Food and... PROVISIONALLY LISTED COLORS AND SPECIFICATIONS Drugs and Cosmetics § 82.1255 D&C Orange No. 5. (a) The color additive D&C Orange No. 5 shall conform in identity and specifications to the requirements of § 74.1255(a...

  18. 21 CFR 74.1255 - D&C Orange No. 5.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 1 2010-04-01 2010-04-01 false D&C Orange No. 5. 74.1255 Section 74.1255 Food and... ADDITIVES SUBJECT TO CERTIFICATION Drugs § 74.1255 D&C Orange No. 5. (a) Identity. (1) the color additive D&C Orange No. 5 is a mixture consisting principally the sodium salt of 4′,5′-dibromofluorescein (CAS...

  19. 21 CFR 82.1254 - D&C Orange No. 4.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 1 2010-04-01 2010-04-01 false D&C Orange No. 4. 82.1254 Section 82.1254 Food and... PROVISIONALLY LISTED COLORS AND SPECIFICATIONS Drugs and Cosmetics § 82.1254 D&C Orange No. 4. The color additive D&C Orange No. 4 shall conform in identity and specifications to the requirements of § 74.1254(a...

  20. Decomposition of Variance for Spatial Cox Processes.

    Science.gov (United States)

    Jalilian, Abdollah; Guan, Yongtao; Waagepetersen, Rasmus

    2013-03-01

    Spatial Cox point processes is a natural framework for quantifying the various sources of variation governing the spatial distribution of rain forest trees. We introduce a general criterion for variance decomposition for spatial Cox processes and apply it to specific Cox process models with additive or log linear random intensity functions. We moreover consider a new and flexible class of pair correlation function models given in terms of normal variance mixture covariance functions. The proposed methodology is applied to point pattern data sets of locations of tropical rain forest trees.

  1. Orange fiber as a novel fat replacer in lemon ice cream

    Directory of Open Access Journals (Sweden)

    Tainara de Moraes Crizel

    2014-06-01

    Full Text Available Orange fiber was used as a novel fat replacer in light lemon ice cream. Nine ice cream formulations were compared: standard control ice cream (IC; ice cream with fiber (F1 from the peel, bagasse, and orange seed (ICA and ICB; ice cream with fiber (F2 from the orange peel alone (ICC and ICD; ice cream with fiber (F3 from the peel, bagasse, and orange seed pretreated with hydro-distillation (ICE and ICF; and ice cream with fiber (F4 from the orange peel pretreated with hydro-distillation (ICG and ICH.The orange fiber reduced the ice cream fat content (50 % and the overrun ratio and increased the fiber content and the hardness, gumminess, and springiness values, but it did not affect the adhesiveness and odor of the samples. The samples with 1.0 % of orange fiber showed low melting rate values than those of the control ice cream. The overall acceptance of the ice cream with 1.0 % of pre-treated orange peel fiber did not differ from that of the control ice cream (80 %. The orange fiber proved a promising food ingredient since it can be used to decrease the fat content and increase bioactive compounds content, such as fiber and carotenoids.

  2. COX-2, VEGF and tumour angiogenesis.

    LENUS (Irish Health Repository)

    Toomey, D P

    2009-06-01

    Epidemiological evidence suggests a protective effective of regular NSAID use against developing cancer. Cyclooxygenase-2, a target of NSAIDs, is upregulated in many cancers and has been associated with increased VEGF production and angiogenesis. Angiogenesis is the formation of new vessels from existing vasculature and as an essential process for tumour development represents an important therapeutic target. Following an extensive review of the literature this article details the current knowledge on the role of COX-2 in tumorigenesis focusing on its relationship to angiogenesis and VEGF production by tumour cells. While COX-2 is clearly detrimental to prognosis and NSAIDs have a beneficial effect, the possibility of COX-2 independent effects being partly or wholly responsible for this benefit cannot be excluded.

  3. Flavonoids targeting of IκB phosphorylation abrogates carcinogen-induced MMP-9 and COX-2 expression in human brain endothelial cells

    Directory of Open Access Journals (Sweden)

    Tahanian E

    2011-05-01

    Full Text Available Elizabeth Tahanian¹, Luis Arguello Sanchez¹, Tze Chieh Shiao², René Roy², Borhane Annabi¹¹Centre de Recherche BioMED, ²Centre de Recherche PharmaQAM, Département de chimie, Université du Québec à Montréal, QC, CanadaAbstract: Brain endothelial cells play an essential role as structural and functional components of the blood–brain barrier (BBB. Increased BBB breakdown and brain injury are associated with neuroinflammation and are thought to trigger mechanisms involving matrix metalloproteinase upregulation. Emerging evidence also indicates that cyclooxygenase (COX inhibition limits BBB disruption, but the mechanisms linking metalloproteinase to COX remain unknown. In this study, we sought to investigate the nuclear factor-kappa B (NF-κB signaling pathway, a common pathway in both the regulation of matrix metalloproteinase-9 (MMP-9 and COX-2 expression, and the inhibitory properties of several chemopreventive flavonoids. Human brain microvascular endothelial cells were treated with a combination of phorbol 12-myristate 13-acetate (PMA, a carcinogen documented to increase MMP-9 and COX-2 through NF-κB, and several naturally occurring flavonoids. Among the molecules tested, we found that fisetin, apigenin, and luteolin specifically and dose-dependently antagonized PMA-induced COX-2 and MMP-9 gene and protein expressions as assessed by qRT-PCR, immunoblotting, and zymography respectively. We further demonstrate that flavonoids impact on IκK-mediated phosphorylation activity as demonstrated by the inhibition of PMA-induced IκB phosphorylation levels. Our results suggest that BBB disruption during neuroinflammation could be pharmacologically reduced by a specific class of flavonoids acting as NF-κB signal transduction inhibitors.Keywords: blood–brain barrier, flavonoids, neuroinflammation, NF-κB signal transduction inhibitors

  4. MedSun Reports

    Data.gov (United States)

    U.S. Department of Health & Human Services — The Medical Product Safety Network (MedSun) is an adverse event reporting program launched in 2002. The primary goal for MedSun is to work collaboratively with the...

  5. 7 CFR 29.1044 - Orange Red (FR).

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 2 2010-01-01 2010-01-01 false Orange Red (FR). 29.1044 Section 29.1044 Agriculture Regulations of the Department of Agriculture AGRICULTURAL MARKETING SERVICE (Standards, Inspections, Marketing... Type 92) § 29.1044 Orange Red (FR). A yellowish red. [42 FR 21092, Apr. 25, 1977. Redesignated at 47 FR...

  6. 21 CFR 74.1260 - D&C Orange No. 10.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 1 2010-04-01 2010-04-01 false D&C Orange No. 10. 74.1260 Section 74.1260 Food... COLOR ADDITIVES SUBJECT TO CERTIFICATION Drugs § 74.1260 D&C Orange No. 10. (a) Identity. (1) The color additive D&C Orange No. 10 is a mixture consisting principally of 4′,5′-diiodofluorescein, 2′,4′,5...

  7. Pectin methyl esterase activity in apple and orange pulps

    International Nuclear Information System (INIS)

    Abdullaev, A.; Djumaev, B.B.; Djumaev, N.B.; Mukhidinov, Z.K.

    2008-01-01

    The results of pectin methyl esterase activity from apple, orange pulp and orange peel depending of ph and temperature are discussed. It's shown that the methyl esterase activity form apple and orange pulps higher in range of temperatures from +37...+60 d ig C . The analysis of dependence of its activity from ph has shown that in both case the enzyme activity increase with increase of ph

  8. 7 CFR 905.306 - Orange, Grapefruit, Tangerine and Tangelo Regulation.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 8 2010-01-01 2010-01-01 false Orange, Grapefruit, Tangerine and Tangelo Regulation... AGRICULTURE ORANGES, GRAPEFRUIT, TANGERINES, AND TANGELOS GROWN IN FLORIDA Grade and Size Requirements § 905.306 Orange, Grapefruit, Tangerine and Tangelo Regulation. (a) During the period specified in column (2...

  9. Acute upregulation of COX-2 by renal artery stenosis

    DEFF Research Database (Denmark)

    Mann, Birgitte; Hartner, A; Jensen, B L

    2001-01-01

    This study aimed to characterize the influence of acute renal artery stenosis on cyclooxygenase-2 (COX-2) and renin expression in the juxtaglomerular apparatus. For this purpose, male Sprague-Dawley rats received a left renal artery clip, and COX-2 mRNA, COX-2 immunoreactivity, plasma renin...... activity, and renin mRNA levels were determined. COX-2 mRNA and COX-2 immunoreactivity in the macula densa region in the clipped kidneys increased as early as 6 h after clipping and reached a maximal expression 1-2 days after clipping. Although values for plasma renin activity were elevated markedly at all...... time points examined, remaining renin mRNA levels were unchanged after 6 h and then increased to reach a maximum value 1-2 days after clipping. In the contralateral intact kidney, renin mRNA and COX-2 immunoreactivity decreased to approximately 50% of their normal values. To investigate a possible...

  10. Cox-2 inhibitors and the risk of cardiovascular thrombotic events.

    LENUS (Irish Health Repository)

    Khan, M

    2012-04-01

    In 1971, Vane showed that the analgesic action of traditional NSAIDs relies on inhibition of the cyclo-oxygenase (COX) enzyme, which in turn results in reduced synthesis of proalgesic prostaglandins. Two decades later COX was shown to exist as two distinct isoforms. The constitutive isoform COX-1, supports the beneficial homeostatic functions whereas the inducible isoform, COX-2 becomes up regulated by inflammatory mediators and its products cause many of the symptoms of inflammatory diseases such as rheumatoid and osteoarthritis. Despite the benefits of NSAIDs for acute and chronic pain one of the most clinically significant and well characterized adverse effect is on GI mucosa. The search for NSAIDs with less gastrointestinal toxicity led to the introduction of the selective cyclo-oxygenase-2 (COX-2) inhibitors. The COX-2 selective (COX-1 sparing) inhibitors are associated with reduced GI mucosal damage as demonstrated in several trials. In light of the overwhelming and sometimes contradictory information for patients and physicians regarding the safety of COX-2 agents this article will summarize the available evidence regarding cardiovascular (CV) safety data and contemporary recommendations for prescribing of COX-2-selective NSAIDs.

  11. Single cell protein production from mandarin orange peel

    Energy Technology Data Exchange (ETDEWEB)

    Nishio, N.; Nagai, S.

    1981-01-01

    As the hydrolysis of mandarin orange peel with macerating enzyme (40/sup 0/C,24 h)produced 0.59 g g/sup -1/ reducing sugar per dry peel compared to 0.36 by acid-hydrolysis (15 min at 120/sup 0/C with 0.8 N H/sub 2/SO/sub 4/), the production of single cell protein (SCP) from orange peel was studied mostly using enzymatically hydrolyzed orange peel. When the enzymatically hydrolyzed peel media were used, the utilization efficiency of reducing sugars (%) and the growth yield from reducing sugars (gg/sup -1/)were: 63 and 0.51 for Saccharomyces cerevisiae; 56 and 0.48 for Candida utilis; 74 and 0.69 for Debaryomyces hansenii and 64 and 0.70 for Rhodotorula glutinis. SCP production from orange peel by D. hansenii and R. glutinis were further studied. Batch cultures for 24 h at 30/sup 0/C using 100 g dried orange peel produced 45 g of dried cultivated peel (protein content, 33%) with D. hansenii and 34 g (protein content, 50%) with R. glutinis, and 38 g (protein content, 44%) with a mixture of both yeasts.

  12. 76 FR 52563 - Special Local Regulations; Sabine River, Orange, TX

    Science.gov (United States)

    2011-08-23

    ...-AA08 Special Local Regulations; Sabine River, Orange, TX AGENCY: Coast Guard, DHS. ACTION: Temporary... Regulations; Sabine River, Orange, TX in the Federal Register (76 FR 103). We received no comments on the... Regulations for Marine Events; Sabine River, Orange, TX. (a) Definitions. As used in this section...

  13. 75 FR 41119 - Special Local Regulations; Sabine River, Orange, TX

    Science.gov (United States)

    2010-07-15

    ...-AA08 Special Local Regulations; Sabine River, Orange, TX AGENCY: Coast Guard, DHS. ACTION: Notice of... the Port Arthur Captain of the Port Zone on the Sabine River, Orange, Texas. This Special Local... Orange, TX, Thunder on the Sabine boat races. The powerboat race and associated testing will occur...

  14. The MedDRA paradox.

    Science.gov (United States)

    Merrill, Gary H

    2008-11-06

    MedDRA (the Medical Dictionary for Regulatory Activities Terminology) is a controlled vocabulary widely used as a medical coding scheme. However, MedDRA's characterization of its structural hierarchy exhibits some confusing and paradoxical features. The goal of this paper is to examine these features, determine whether there is a coherent view of the MedDRA hierarchy that emerges, and explore what lessons are to be learned from this for using MedDRA and similar terminologies in a broad medical informatics context that includes relations among multiple disparate terminologies, thesauri, and ontologies.

  15. Geometric anisotropic spatial point pattern analysis and Cox processes

    DEFF Research Database (Denmark)

    Møller, Jesper; Toftaker, Håkon

    . In particular we study Cox process models with an elliptical pair correlation function, including shot noise Cox processes and log Gaussian Cox processes, and we develop estimation procedures using summary statistics and Bayesian methods. Our methodology is illustrated on real and synthetic datasets of spatial...

  16. Orange fiber laser for ophthalmology

    Science.gov (United States)

    Adachi, M.; Kojima, K.; Hayashi, K.

    2007-02-01

    For the light source of photocoagulators for ophthalmology, orange laser is more suitable than green laser because of low scattering loss by the crystalline lens, and low absorption by xanthophylls in the retina. We developed two orange fiber lasers (580 nm and 590 nm) to investigate the effect depending on the difference in the range of orange. The 580nm laser is composed of a 1160 nm fiber laser and a Periodically Polled Lithium Niobate (PPLN) crystal for second harmonic generation. The 1160 nm fiber laser beam is focused into the MgO-doped PPLN crystal whose length is 30 mm with 3-pass configuration. Continuous-wave 1.3 W output power of 580 nm was obtained with 5.8 W input power of 1160nm for the first time. The conversion efficiency was 22%. The band width of the second harmonic was 0.006 nm (FWHM). The 590 nm laser is almost the same as 580 nm laser source. In this case we used a Raman shift fiber to generate 1180 nm, and the output power of 590 nm was 1.4 W. We developed an evaluation model of photocoagulator system using these two laser sources. A 700 mW coagulation output power was obtained with this orange fiber laser photocoagulator system. This is enough power for the eye surgery. We have the prospect of the maintenance-free, long-life system that is completely air-cooled. We are planning to evaluate this photocoagulator system in order to investigate the difference between the two wavelengths at the field test.

  17. 75 FR 55968 - Special Local Regulations, Sabine River; Orange, TX

    Science.gov (United States)

    2010-09-15

    ...-AA08 Special Local Regulations, Sabine River; Orange, TX AGENCY: Coast Guard, DHS. ACTION: Temporary... Arthur Captain of the Port Zone on the Sabine River, Orange, Texas. This Special Local Regulation is... River, Orange, TX in the Federal Register (75 FR 41119). We received no comments on the proposed rule...

  18. 21 CFR 146.148 - Reduced acid frozen concentrated orange juice.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 2 2010-04-01 2010-04-01 false Reduced acid frozen concentrated orange juice. 146... Canned Fruit Juices and Beverages § 146.148 Reduced acid frozen concentrated orange juice. (a) Reduced acid frozen concentrated orange juice is the food that complies with the requirements for composition...

  19. Trouble Brewing in Orange County. Policy Brief

    Science.gov (United States)

    Buck, Stuart

    2010-01-01

    Orange County will soon face enormous budgetary pressures from the growing deficits in public pensions, both at a state and local level. In this policy brief, the author estimates that Orange County faces a total $41.2 billion liability for retiree benefits that are underfunded--including $9.4 billion for the county pension system and an estimated…

  20. Analysis of PubMed User Sessions Using a Full-Day PubMed Query Log: A Comparison of Experienced and Nonexperienced PubMed Users

    Science.gov (United States)

    2015-01-01

    Background PubMed is the largest biomedical bibliographic information source on the Internet. PubMed has been considered one of the most important and reliable sources of up-to-date health care evidence. Previous studies examined the effects of domain expertise/knowledge on search performance using PubMed. However, very little is known about PubMed users’ knowledge of information retrieval (IR) functions and their usage in query formulation. Objective The purpose of this study was to shed light on how experienced/nonexperienced PubMed users perform their search queries by analyzing a full-day query log. Our hypotheses were that (1) experienced PubMed users who use system functions quickly retrieve relevant documents and (2) nonexperienced PubMed users who do not use them have longer search sessions than experienced users. Methods To test these hypotheses, we analyzed PubMed query log data containing nearly 3 million queries. User sessions were divided into two categories: experienced and nonexperienced. We compared experienced and nonexperienced users per number of sessions, and experienced and nonexperienced user sessions per session length, with a focus on how fast they completed their sessions. Results To test our hypotheses, we measured how successful information retrieval was (at retrieving relevant documents), represented as the decrease rates of experienced and nonexperienced users from a session length of 1 to 2, 3, 4, and 5. The decrease rate (from a session length of 1 to 2) of the experienced users was significantly larger than that of the nonexperienced groups. Conclusions Experienced PubMed users retrieve relevant documents more quickly than nonexperienced PubMed users in terms of session length. PMID:26139516

  1. Palm distributions for log Gaussian Cox processes

    DEFF Research Database (Denmark)

    Coeurjolly, Jean-Francois; Møller, Jesper; Waagepetersen, Rasmus

    This paper reviews useful results related to Palm distributions of spatial point processes and provides a new result regarding the characterization of Palm distributions for the class of log Gaussian Cox processes. This result is used to study functional summary statistics for a log Gaussian Cox...

  2. Evaluering af ordning med psykologbehandling af personer med let til moderat depression

    DEFF Research Database (Denmark)

    Fjeldsted, Rita; Christensen, Kaj Sparle

    Herværende rapport evaluerer den pr. 1.4.2008 indførte ordning med mulighed for henvisning til psykologbehandling med 60 % tilskud for patienter med let til moderat depression. Evalueringen har betjent sig af flere gensidigt supplerende metoder: spørgeskemaundersøgelser overfor patienter, psykolo......Herværende rapport evaluerer den pr. 1.4.2008 indførte ordning med mulighed for henvisning til psykologbehandling med 60 % tilskud for patienter med let til moderat depression. Evalueringen har betjent sig af flere gensidigt supplerende metoder: spørgeskemaundersøgelser overfor patienter...... tidligere evaluering af forsøgsordning af psykologbehandling af depression i perioden 2005-06. 18.419 personer i alderen 18-37 år blev henvist til psykolog i den undersøgte ordning i perioden 1.2.2009 – 31.1.2010, svarende til en henvisningshyppighed på 1,6 % af baggrundsbefolkningen i samme aldersgruppe....... Ordningen giver mulighed for én rehenvisning, og 9 % blev rehenvist i perioden. Spørgeskemaresultater viser, at kun 33 % af de henviste falder ind under henvisningskriteriet ” let til moderat depression” på tidspunktet for opstart af psykologbehandling, 39 % har ingen tegn på depression, og 28 % har svær...

  3. Production and Marketing of Orange in Two Villages in Muheza District, Tanzania

    OpenAIRE

    MHANDO, David Gongwe; IKENO, Jun

    2018-01-01

    This study examines the current situation and challenges in orange production and marketing in Muheza District, Tanga Region, Tanzania. Tanga Region is a major orange production area in Tanzania, and it is estimated that more than 80% of all oranges in Tanga Region are produced in Muheza District. Utilizing field data collected in Mkuzi and Mindu villages in Muheza District, this paper explores the current situation of orange production and marketing. Orange production makes a substantial con...

  4. An overview on the Brazilian orange juice production chain

    Directory of Open Access Journals (Sweden)

    Renato Marcio dos Santos

    2013-03-01

    Full Text Available Brazil is the world's largest producer of oranges and uses more than 70% of the harvested fruits in the production of juices. The amount of processed orange is growing about 10% per year, confirming the trend of the Brazilian citrus for juice production. This research aimed to investigate the Brazilian orange juice production chain from 2005 to 2009. Data from the amount of frozen juice produced and exported, international price of orange juice, and intermediate transactions were assessed in order to make possible selection of all interveners involved in the chain. The study using the Social Network Analysis (SNA showed that the densest relationships in the network are from exporters to importers and from orange growers to the orange processing industry. No difference was found in the values of the network geodesic distance or the clustering coefficients from 2005 to 2009. The degree of centrality increased steadily throughout the years indicating that the processing industry attempts to minimize the risks by centralizing the actions. A decrease in export of orange juice from 2007 (2.07 10(6 t to 2008 (2.05 10(6 t was found, probably due to the world's financial crisis with recovery in 2009. Since 2004, there has been an increase of nearly 10% per year in the market preference of concentrate juice (OFCJ when compared to the "not from concentrated" juice (NFC. Nowadays the NFC market represents nearly 50% of all Brazilian export which impacted in the logistic distribution and transportation issues.

  5. 76 FR 30890 - Special Local Regulations; Sabine River, Orange, TX

    Science.gov (United States)

    2011-05-27

    ...-AA08 Special Local Regulations; Sabine River, Orange, TX AGENCY: Coast Guard, DHS. ACTION: Notice of... the Port Arthur Captain of the Port Zone on the Sabine River, Orange, Texas on September 24-25, 2011... race in conjunction with the Orange, TX S.P.O.R.T. boat races. The powerboat race and associated...

  6. FAKTOR PENDORONG DAN PENARIK ORANG BALI BERWISATA KE LUAR NEGERI

    Directory of Open Access Journals (Sweden)

    Ni Wayan Ana Pradnya Dewi

    2017-02-01

    Full Text Available Berwisata saat ini sudah menjadi gaya hidup bagi masyarakat, tak terkecuali orang Bali. Beberapa tahun terakhir tercatat banyak orang Bali yang berlibur, bahkan hingga ke luar negeri. Penelitian ini bertujuan untuk mengetahui profil demografis orang Bali dan negara yang dikunjungi, faktor pendorong dan penarik, menganalisis tingkat motivasi dan perbedaan motivasi orang Bali yang pertama kali dan yang sering berwisata ke luar negeri. Teori Motivasi dan Teori Hirarki Kebutuhan Maslow digunakan dalam penelitian ini. Pengumpulan data menggunakan metode wawancara dan kuesioner dengan teknik Quota Sampling. Teknik analisis data dilakukan dengan analisis deskriptif kualitatif dan analisis statistik Diskriminan. Hasil penelitian menunjukkan bahwa motivasi orang Bali sangat beragam, responden dapat memiliki motivasi lebih dari satu. Faktor pendorong yang paling dominan adalah educational opportunity disamping motif lain seperti relaxation dan play, sedangkan faktor penarik yang dominan adalah cultural factors, diikuti oleh natural environment dan recreation and attraction services. Ditemukan pula adanya perbedaan motivasi di antara orang Bali yang pertama kali dan yang sering melakukan perjalanan wisata ke luar negeri.

  7. Strukturalisme Genetik Lucien Goldmann dalam Novel Orang-Orang Proyek Karya Ahmad Tohari

    Directory of Open Access Journals (Sweden)

    Dewi Nurhasanah

    2015-01-01

    Full Text Available Article clarified structure, global view of social class, and social structure function as the background of Orang-orang Proyek, a novel by Ahmad Tohari. Research applied analytic and dialectic descriptive method. Analysis was done by applying Genetic Structuralism theory by Lucien Goldmann to see the meaning of the novel by relating the structure of the novel with the human facts (social structure as a background of the novel. The research results indicate that the novel structure described some oppositions, those are cultural, natural, social, and human oppositions; the novel’s structure expresses a global views, those are ideal-humanist and social-religious; when the novel was written, there were some corruption cases in the social structure in Indonesia that was adopted in the novel. Therefore, there seems a correlation between the novel structure and the social structure. 

  8. Cell-type-specific roles for COX-2 in UVB-induced skin cancer

    Science.gov (United States)

    Herschman, Harvey

    2014-01-01

    In human tumors, and in mouse models, cyclooxygenase-2 (COX-2) levels are frequently correlated with tumor development/burden. In addition to intrinsic tumor cell expression, COX-2 is often present in fibroblasts, myofibroblasts and endothelial cells of the tumor microenvironment, and in infiltrating immune cells. Intrinsic cancer cell COX-2 expression is postulated as only one of many sources for prostanoids required for tumor promotion/progression. Although both COX-2 inhibition and global Cox-2 gene deletion ameliorate ultraviolet B (UVB)-induced SKH-1 mouse skin tumorigenesis, neither manipulation can elucidate the cell type(s) in which COX-2 expression is required for tumorigenesis; both eliminate COX-2 activity in all cells. To address this question, we created Cox-2 flox/flox mice, in which the Cox-2 gene can be eliminated in a cell-type-specific fashion by targeted Cre recombinase expression. Cox-2 deletion in skin epithelial cells of SKH-1 Cox-2 flox/flox;K14Cre + mice resulted, following UVB irradiation, in reduced skin hyperplasia and increased apoptosis. Targeted epithelial cell Cox-2 deletion also resulted in reduced tumor incidence, frequency, size and proliferation rate, altered tumor cell differentiation and reduced tumor vascularization. Moreover, Cox-2 flox/flox;K14Cre + papillomas did not progress to squamous cell carcinomas. In contrast, Cox-2 deletion in SKH-1 Cox-2 flox/flox; LysMCre + myeloid cells had no effect on UVB tumor induction. We conclude that (i) intrinsic epithelial COX-2 activity plays a major role in UVB-induced skin cancer, (ii) macrophage/myeloid COX-2 plays no role in UVB-induced skin cancer and (iii) either there may be another COX-2-dependent prostanoid source(s) that drives UVB skin tumor induction or there may exist a COX-2-independent pathway(s) to UVB-induced skin cancer. PMID:24469308

  9. Semangat Islam Dalam Kebudayaan Orang Bugis-Makassar

    Directory of Open Access Journals (Sweden)

    Abu Hamid

    2006-06-01

    Full Text Available Pembahasan masalah semangat dan etos sosial tidak terlepas dari jangkauan sistem budaya masyarakat. Sistem budaya adalah abstrak, tak dapat dilihat dan diraba, ia identik pada komunitas, berada di kepala dan sukma tiap orang dalam komunitas tersebut, terdiri atas konsep-konsep, gagasan ide-ide dan kepercayaan yang diterima setiap orang dari hasil perkembangan kebudayaannya. Sadar atau tidak sadar, manusia terpengaruh dan menerima berbagai warisan, ajaran, kepercayaan dan ideologi tertentu dan hasil kerja komunitasnya melalui internalisasi sejak ia lahir dari dalam rumah tangga serta pengeruh dari lingkungan hidupnya tempat manusia tersebut bertumbuh. Kalau tradisi budaya masyarakat telah diserapi oleh setiap orang, maka perilakunya hampir menjadi otomatis, tanpa disadari perilakunya itu sudah diterima secara sosial.

  10. Sammensvorne designere med succes

    DEFF Research Database (Denmark)

    Dickson, Thomas

    2005-01-01

    Den danske tegnestue Komplot Design har for nylig oplevet den ære, at to af deres stole bliver brugt i cafeerne på det nyindrettede Museum of Modern Art i New York. Men det er ikke kun med møbler, de har succes - tegnestuen kaster sig med iver over mange slags produkter.......Den danske tegnestue Komplot Design har for nylig oplevet den ære, at to af deres stole bliver brugt i cafeerne på det nyindrettede Museum of Modern Art i New York. Men det er ikke kun med møbler, de har succes - tegnestuen kaster sig med iver over mange slags produkter....

  11. Processeringsoptimering med Canons software

    DEFF Research Database (Denmark)

    Precht, Helle

    2009-01-01

    . Muligheder i software optimering blev studeret i relation til optimal billedkvalitet og kontrol optagelser, for at undersøge om det var muligt at acceptere diagnostisk billedkvalitet og derved tage afsæt i ALARA. Metode og materialer Et kvantitativt eksperimentelt studie baseret på forsøg med teknisk og...... humant fantom. CD Rad fantom anvendes som teknisk fantom, hvor billederne blev analyseret med CD Rad software, og resultatet var en objektiv IQF værdi. Det humane fantom var et lamme pelvis med femur, der via NRPB’ er sammenlignelig med absorptionen ved et femårigt barn. De humane forsøgsbilleder blev...

  12. The Orange Feeling

    DEFF Research Database (Denmark)

    Kiib, Hans; Kiib, Birgitte Marling; Jespersen, Line Marie Bruun

    2017-01-01

    on the specific atmosphere and on how the designs support this. It concludes that the culture of laughter is the atmospheric glue that keeps Roskilde Festival together, and it is the performative and relational designs together with the culture of laughter that create the basis for ‘The Orange Feeling’....

  13. Bioactive compounds from orange epicarp to enrich fish burgers.

    Science.gov (United States)

    Spinelli, Sara; Lecce, Lucia; Likyova, Desislava; Del Nobile, Matteo Alessandro; Conte, Amalia

    2018-05-01

    The orange industry produces considerable amounts of by-products, traditionally used for animal feed or fuel production. Most of these by-products could be used as functional ingredients. To assess the potential food application of orange epicarp, different percentages of micro-encapsulated orange extract were added to fresh fish burgers. Then, an in vitro digestion was also carried out, before and after micro-encapsulation, to measure the bio-accessibility of the active compounds. A significant increase of bio-accessibility of bioactive compounds has been observed in the orange epicarp extract after micro-encapsulation by spray-drying. From the sensory point of view, the fish sample enriched with 50 g kg -1 micro-encapsulated extract was the most comparable to the control burger, even if it showed a higher phenolic, flavonoid and carotenoid bio-accessibility. Orange epicarp may be used as a food additive to enhance the health content of food products. The micro-encapsulation is a valid technique to protect the bioactive compounds and increase their bio-accessibility. © 2017 Society of Chemical Industry. © 2017 Society of Chemical Industry.

  14. PubMed-EX: a web browser extension to enhance PubMed search with text mining features.

    Science.gov (United States)

    Tsai, Richard Tzong-Han; Dai, Hong-Jie; Lai, Po-Ting; Huang, Chi-Hsin

    2009-11-15

    PubMed-EX is a browser extension that marks up PubMed search results with additional text-mining information. PubMed-EX's page mark-up, which includes section categorization and gene/disease and relation mark-up, can help researchers to quickly focus on key terms and provide additional information on them. All text processing is performed server-side, freeing up user resources. PubMed-EX is freely available at http://bws.iis.sinica.edu.tw/PubMed-EX and http://iisr.cse.yzu.edu.tw:8000/PubMed-EX/.

  15. Ulykke med hækkesaks

    DEFF Research Database (Denmark)

    Leth, Peter Mygind

    1996-01-01

    Snitsår med blødning fra en overskåret pulsåre på armen forekommer hyppigt ved selvmordsforsøg, men har sjældent et dødeligt forløb. Her gives et eksempel på en isoleret partiel overklipning af a.ulnaris ved en ulykke med en hækkesaks med dødelig forløbende blødning.......Snitsår med blødning fra en overskåret pulsåre på armen forekommer hyppigt ved selvmordsforsøg, men har sjældent et dødeligt forløb. Her gives et eksempel på en isoleret partiel overklipning af a.ulnaris ved en ulykke med en hækkesaks med dødelig forløbende blødning....

  16. Expression of beta-catenin, COX-2 and iNOS in colorectal cancer: relevance of COX-2 adn iNOS inhibitors for treatment in Malaysia.

    Science.gov (United States)

    Hong, Seok Kwan; Gul, Yunus A; Ithnin, Hairuszah; Talib, Arni; Seow, Heng Fong

    2004-01-01

    Promising new pharmacological agents and gene therapy targeting cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS) could modulate treatment of colorectal cancer in the future. The aim of this study was to elucidate the expression fo beta-catenin and teh presence of COX-2 and iNOS in colorectal cancer specimens in Malaysia. This is a useful prelude to future studies investigating interventions directed towards COX-2 adn iNOS. A cross-section study using retrospective data over a 2-year period (1999-2000) involved 101 archival, formalin-fixed, paraffin-embedded tissue samples of colorectal cancers that were surgically resected in a tertiary referral. COX-2 production was detected in adjacent normal tissue in 34 sample (33.7%) and in tumour tissue in 60 samples (59.4%). More tumours expressed iNOS (82/101, 81.2%) than COX-2. No iNOS expression was detected in adjacent normal tissue. Intense beta-catenin immunoreactivity at the cell-to-cell border. Poorly differentiated tumours had significantly lower total beta-catenin (p = 0.009) and COX-2 scores (p = 0.031). No significant relationships were established between pathological stage and beta-catenin, COX-2 and iNOS scores. the accumulation of beta-catenin does not seem to be sufficient to activate pathways that lead to increased COX-2 and iNOS expression. A high proportion of colorectal cancers were found to express COX-2 and a significant number produced iNOS, suggesting that their inhibitors may be potentially useful as chemotherapeutic agents in the management of colorectal cancer.

  17. Comparative and demographic analysis of orang-utan genomes

    DEFF Research Database (Denmark)

    Locke, Devin P.; Hillier, LaDeana W.; Warren, Wesley C.

    2011-01-01

    Orang-utan’ is derived from a Malay term meaning ‘man of the forest’ and aptly describes the southeast Asian great apes native to Sumatra and Borneo. The orang-utan species, Pongo abelii (Sumatran) and Pongo pygmaeus (Bornean), are the most phylogenetically distant great apes from humans, thereb...

  18. Fracto- mechanoluminescence and thermoluminescence properties of orange-red emitting Eu3+ doped Ca2Al2SiO7 phosphors

    International Nuclear Information System (INIS)

    Tiwari, Geetanjali; Brahme, Nameeta; Sharma, Ravi; Bisen, D.P.; Sao, Sanjay K.; Khare, Ayush

    2017-01-01

    The suitability of nano-structured Ca 2 Al 2 SiO 7 :Eu 3+ phosphors for thermoluminescence and mechanoluminescence dosimeter were investigated. Europium doped di-calcium di-aluminum silicate phosphor was synthesised by the combustion assisted method and annealed at 1100 °C for 4 h in reducing and oxidizing environments. The prepared Ca 2 Al 2 SiO 7 :Eu 3+ phosphor was characterized by X-ray diffractometer (XRD), transmission electron microscopy (TEM), scanning electron microscopy (SEM) with energy dispersive x-ray spectroscopy (EDX), photoluminescence (PL) and decay characteristics. The phase structure of sintered phosphor has akermanite type which belongs to the tetragonal crystallography; this structure is a member of the melilite group and forms a layered compound. The chemical composition of the sintered Ca 2 Al 2 SiO 7 :Eu 3+ phosphor was confirmed by EDX spectra. Mechanoluminescence (ML) and thermoluminescence (TL) studies revealed that the ML and TL intensity increases with activator concentration. Optimum ML was observed for the sample having 2 mol% of Eu ions. The TL intensity of Ca 2 Al 2 SiO 7 :Eu 3+ was recorded for different exposure times of γ -irradiation and it was observed that TL intensity is maximum for γ dose of 1770 Gy. The PL spectra indicated that Ca 2 Al 2 SiO 7 :Eu 3+ could be excited effectively by near ultraviolet (NUV) light and exhibited bright orange-red emission with excellent colour stability. CIE colour coordinates of the prepared Ca 2 Al 2 SiO 7 :Eu 3+ phosphor was found suitable as orange-red light emitting phosphor with a CIE value of (x=0.6142, y=0.3849) and correlated colour temperature (CCT) is 1250 K. Therefore, it is considered to be a new promising orange-red emitting phosphor for white light emitting diode (LED) application.

  19. BOX-COX REGRESSION METHOD IN TIME SCALING

    Directory of Open Access Journals (Sweden)

    ATİLLA GÖKTAŞ

    2013-06-01

    Full Text Available Box-Cox regression method with λj, for j = 1, 2, ..., k, power transformation can be used when dependent variable and error term of the linear regression model do not satisfy the continuity and normality assumptions. The situation obtaining the smallest mean square error  when optimum power λj, transformation for j = 1, 2, ..., k, of Y has been discussed. Box-Cox regression method is especially appropriate to adjust existence skewness or heteroscedasticity of error terms for a nonlinear functional relationship between dependent and explanatory variables. In this study, the advantage and disadvantage use of Box-Cox regression method have been discussed in differentiation and differantial analysis of time scale concept.

  20. Advancing the Orang Asli through Malaysia's Clusters of Excellence Policy

    Directory of Open Access Journals (Sweden)

    Mohd Asri Mohd Noor

    2012-10-01

    Full Text Available Since gaining independence in 1957, the government of Malaysia has introduced various programmes to improve the quality of life of the Orang Asli (aboriginal people. The Ministry of Education, for example, is committed in providing education for all including the children of Orang Asli. However, whilst the number of Orang Asli children enrolled in primary and secondary schools has increased significantly over the last decade, the dropout rate among them is still high. This has been attributed to factors such as culture, school location, poverty, pedagogy and many more. The discussion in this article is drawn upon findings from fieldwork study at an Orang Asli village in Johor, Malaysia. This article discusses efforts in raising educational attainment of the Orang Asli through the implementation of the Clusters of Excellence Policy. In so doing it highlights the achievement of the policy and issues surrounding its implementation at the site.

  1. Efficacy and safety of COX-2 inhibitors for advanced non-small-cell lung cancer with chemotherapy: a meta-analysis

    Directory of Open Access Journals (Sweden)

    Dai P

    2018-02-01

    Full Text Available Ping Dai, Jing Li, Xiao-Ping Ma, Jian Huang, Juan-Juan Meng, Ping Gong Department of Oncology, The First Affiliated Hospital, Shihezi University School of Medicine, Shihezi, Xinjiang, People’s Republic of China Background: The study of cyclooxygenase-2 (COX-2 inhibitors is now mired in controversy. We performed a meta-analysis to assess the efficacy and safety profile of COX-2 inhibitors in patients with advanced non-small-cell lung cancer (NSCLC.Patients and methods: A literature search of PubMed, EMBASE, the Cochrane Central databases, and ClinicalTrials.gov, up until March 26, 2017, identified relevant randomized controlled trials. Data analysis was performed using Stata 12.0.Results: Six eligible trials (1,794 patients were selected from the 407 studies that were identified initially. A significant difference, favoring COX-2 inhibitors plus chemotherapy over chemotherapy alone, was observed in the overall response rate (relative risk [RR] =1.25, 95% confidence interval [CI]: 1.06–1.48. Further, we conducted two subgroup analyses according to the type of COX-2 inhibitors (celecoxib, rofecoxib, or apricoxib and treatment line (first or second chemotherapy. The first-line treatment includes: NP (changchun red bean + cisplatin or carboplatin, GP (double fluorine cytidine + cisplatin or carboplatin, or TP (paclitaxel + cisplatin or carboplatin, docetaxel + cisplatin or carboplatin. The second-line treatment includes two internationally recognized compounds, one is docetaxel and the other is the pemetrexed, both of which are individually selected. In subgroup analysis, significantly increased overall response rate (ORR results were found for rofecoxib plus chemotherapy (RR =1.56, 95% CI: 1.08–2.25 and COX-2 inhibitor given with first-line chemotherapy (RR =1.27, 95% CI: 1.07–1.50. However, there was no difference between COX-2 inhibitors plus chemotherapy and chemotherapy alone in overall survival (hazard ratio [HR] =1.04, 95% CI: 0.91–1

  2. In vitro and In Silico Studies on Curcumin and Its Analogues as Dual Inhibitors for cyclooxygenase-1 (COX-1 and cyclooxygenase-2 (COX-2

    Directory of Open Access Journals (Sweden)

    Nunung Yuniarti

    2012-03-01

    Full Text Available Curcumin has been widely reported as an anti-inflammatory agent isolated from the plant Curcuma longa L. (turmeric. This anti-inflammatory activity was associated with the ability of this compound to inhibit the activity of both cyclooxygenase-1 (COX-1 and cyclooxygenase-2 (COX-2 in arachidonic acid metabolism. Dual COX-1 and COX-2 inhibitors are preferred to be employed in the therapy of chronic inflammatory diseases compared to selective inhibitors, since it was reported that the use of selective inhibitors led to severe adverse side effect. In the present study, in vitro and in silico assays on curcumin and its analogues as dual inhibitors for both COX-1 and COX-2 were performed. The results provide theoretical contribution in understanding the ligand-protein interactions at the molecular level to develop new curcumin analogues which possess better anti-inflammatory activity as well as to avoid unsolicited side effects.

  3. Differentiation between Flavors of Sweet Orange (Citrus sinensis) and Mandarin (Citrus reticulata).

    Science.gov (United States)

    Feng, Shi; Suh, Joon Hyuk; Gmitter, Frederick G; Wang, Yu

    2018-01-10

    Pioneering investigations referring to citrus flavor have been intensively conducted. However, the characteristic flavor difference between sweet orange and mandarin has not been defined. In this study, sensory analysis illustrated the crucial role of aroma in the differentiation between orange flavor and mandarin flavor. To study aroma, Valencia orange and LB8-9 mandarin were used. Their most aroma-active compounds were preliminarily identified by aroma extract dilution analysis (AEDA). Quantitation of key volatiles followed by calculation of odor activity values (OAVs) further detected potent components (OAV ≥ 1) impacting the overall aromatic profile of orange/mandarin. Follow-up aroma profile analysis revealed that ethyl butanoate, ethyl 2-methylbutanoate, octanal, decanal, and acetaldehyde were essential for orange-like aroma, whereas linalool, octanal, α-pinene, limonene, and (E,E)-2,4-decadienal were considered key components for mandarin-like aroma. Furthermore, an unreleased mandarin hybrid producing fruit with orange-like flavor was used to validate the identification of characteristic volatiles in orange-like aroma.

  4. Assessing a traceability technique in fresh oranges (Citrus sinensis L. Osbeck) with an HS-SPME-GC-MS method. Towards a volatile characterisation of organic oranges.

    Science.gov (United States)

    Cuevas, Francisco Julián; Moreno-Rojas, José Manuel; Ruiz-Moreno, María José

    2017-04-15

    A targeted approach using HS-SPME-GC-MS was performed to compare flavour compounds of 'Navelina' and 'Salustiana' orange cultivars from organic and conventional management systems. Both varieties of conventional oranges showed higher content of ester compounds. On the other hand, higher content of some compounds related with the geranyl-diphosphate pathway (neryl and geranyl acetates) and some terpenoids were found in the organic samples. Furthermore, the partial least square discriminant analysis (PLS-DA) achieved an effective classification for oranges based on the farming system using their volatile profiles (90 and 100% correct classification). To our knowledge, it is the first time that a comparative study dealing with farming systems and orange aroma profile has been performed. These new insights, taking into account local databases, cultivars and advanced analytical tools, highlight the potential of volatile composition for organic orange discrimination. Copyright © 2016 Elsevier Ltd. All rights reserved.

  5. Bio-Diesel Production from Oil of Orange ( Citrus Sinensis ) Peels as ...

    African Journals Online (AJOL)

    Although, in Nigeria orange peels are considered as a waste, this study is intended to convert the waste into wealth by establishing the production of biodiesel with oil obtained from orange peels; using transeterification process. Oil from sun-dried/ ground orange peels were extractedusing n-hexane. Transesterification ...

  6. STRATEGI COPING ORANG TUA MENGHADAPI ANAK AUTIS

    OpenAIRE

    Desi Sulistyo Wardani

    2016-01-01

    Autis merupakan grey area dibidang kedokteran, yang artinya masih merupakan suatu hal yang penyebab, mekanisme, dan terapinya belum jelas benar. Permasalahan yang dihadapi oleh orang tua yang mempunyai anak autis ini memerlukan pemecahan sebagai upaya untuk beradaptasi terhadap masalah dari tekanan yang menimpa mereka. Konsep untuk memecahkan masalah ini disebut coping. Penelitian ini bertujuan untuk mengetahui orientasi strategi coping yang digunakan oleh orang tua untuk menghadapi anak pend...

  7. Genetically engineered orange petunias on the market

    OpenAIRE

    Bashandy, Hany; Teeri, Teemu Heikki

    2017-01-01

    Main conclusion Unauthorized genetically engineered orange petunias were found on the market. Genetic engineering of petunia was shown to lead to novel flower color some 20?years ago. Here we show that petunia lines with orange flowers, generated for scientific purposes, apparently found their way to petunia breeding programmes, intentionally or unintentionally. Today they are widely available, but have not been registered for commerce. Electronic supplementary material The online version of ...

  8. Identification of sensory attributes that drive consumer liking of commercial orange juice products in Korea.

    Science.gov (United States)

    Kim, Mina K; Lee, Young-Jin; Kwak, Han Sub; Kang, Myung-woo

    2013-09-01

    Orange juice is a well-accepted fruit juice, and its consumption increases steadily. Many studies have been conducted to understand the sensory characteristics of orange juice throughout its varying processing steps. Sensory language and consumer likings of food can be influenced by culture. The objective of this study is to evaluate the sensory characteristics of commercially available orange juices in Korea and identify drivers of liking for orange juices in Korea. A quantitative descriptive analysis was conducted using a trained panel (n = 10) to evaluate 7 orange juice samples in triplicates, followed by consumer acceptance tests (n = 103). Univariate and multivariate statistical analyses were conducted for data analysis. The sensory characteristics of commercially available orange juice were documented and grouped: group 1 samples were characterized by high in natural citrus flavors such as orange peel, orange flesh, citrus fruit, and grape fruit, whereas group 2 samples were characterized by processed orange-like flavors such as over-ripe, cooked-orange, and yogurt. Regardless of orange flavor types, a high intensity of orange flavor in orange juice was identified as a driver of liking for orange juices in Korea. Three distinct clusters were segmented by varying sensory attributes that were evaluated by likes and dislikes. Overall, many similarities were noticed between Korean market segment and global orange juice market. By knowing the drivers of liking and understanding the distinct consumer clusters present in the Korean orange juice market, the orange juice industry could improve the strategic marketing of its products in Korea. © 2013 Institute of Food Technologists®

  9. Call cultures in orang-utans?

    Directory of Open Access Journals (Sweden)

    Serge A Wich

    Full Text Available BACKGROUND: Several studies suggested great ape cultures, arguing that human cumulative culture presumably evolved from such a foundation. These focused on conspicuous behaviours, and showed rich geographic variation, which could not be attributed to known ecological or genetic differences. Although geographic variation within call types (accents has previously been reported for orang-utans and other primate species, we examine geographic variation in the presence/absence of discrete call types (dialects. Because orang-utans have been shown to have geographic variation that is not completely explicable by genetic or ecological factors we hypothesized that this will be similar in the call domain and predict that discrete call type variation between populations will be found. METHODOLOGY/PRINCIPAL FINDINGS: We examined long-term behavioural data from five orang-utan populations and collected fecal samples for genetic analyses. We show that there is geographic variation in the presence of discrete types of calls. In exactly the same behavioural context (nest building and infant retrieval, individuals in different wild populations customarily emit either qualitatively different calls or calls in some but not in others. By comparing patterns in call-type and genetic similarity, we suggest that the observed variation is not likely to be explained by genetic or ecological differences. CONCLUSION/SIGNIFICANCE: These results are consistent with the potential presence of 'call cultures' and suggest that wild orang-utans possess the ability to invent arbitrary calls, which spread through social learning. These findings differ substantially from those that have been reported for primates before. First, the results reported here are on dialect and not on accent. Second, this study presents cases of production learning whereas most primate studies on vocal learning were cases of contextual learning. We conclude with speculating on how these findings might

  10. Enhanced orange-red emission by using Mo codoped in Ba2CaWO6: Eu3+, Li+ phosphor under near UV excitation

    International Nuclear Information System (INIS)

    Sun, Xiaoyuan; Hao, Zhendong; Li, Chunjie; He, Xiaoguang; Qi, Haiyan; Yu, Lijun; Luo, Yongshi; Zhang, Jiahua; Gao, Jiwei; Zhong, Ruixia

    2013-01-01

    The orange-red emitting phosphors Ba 2 Ca 0.9 Mo x W 1−x O 6 :Eu 3+ 0.05 , Li + 0.05 (x=0, 0.05, 0.1, 0.15, 0.2, 0.25, 0.5, 0.75, and 1.0) and Ba 2 Ca 1−2y Mo 0.2 W 0.8 O 6 :Eu 3+ y , Li + y (y=0.03, 0.05, 0.07, 0.1, and 0.15) were synthesized. The crystalline structure and photoluminescence properties of these phosphors were described. The strong orange-red emission of Eu 3+ ( 5 D 0 — 7 F 1 transition) at around 593 nm was observed. Addition of Mo strongly enhances the charge transfer band absorption in the near ultraviolet region that corresponds to near ultraviolet white light emitting diode. The dependence of photoluminescence intensities on Eu 3+ concentrations with optimal Mo concentration under 400 nm excitation was studied. The phosphor is considered to be a promising orange-red emitting phosphor for near ultraviolet GaN-based white light emitting diode. - Highlights: ► The samples form solid solutions when Mo is added into Ba 2 CaWO 6 : Eu 3+ , Li + phosphors. ► Addition of Mo in Ba 2 CaWO 6 : Eu 3+ , Li + shifts the PLE spectra maximum from UV region to near UV region. ► In Ba 2 CaMo x W 1−x O 6 :Eu 3+ , Li + , the most efficient concentrations occur at 0.1 and 0.2 for Eu and Mo.

  11. Characterization of orange oil microcapsules for application in textiles

    Science.gov (United States)

    Rossi, W.; Bonet-Aracil, M.; Bou-Belda, E.; Gisbert-Payá, J.; Wilson, K.; Roldo, L.

    2017-10-01

    The use of orange oil presents as an ecological alternative to chemicals, attracting the attention of the scientific community to the development of eco-friendly antimicrobials. The microencapsulation technology has been used for the application of orange oil to textiles, being an economically viable, fast and efficient method by combining core and shell materials, desirable perceptual and functional characteristics, responsible for properties related to the nature of the product and provides that the wall materials release the functional substances in a controlled manner, in addition to effectively protecting and isolating the core material from the external environment to prevent its volatilization and deterioration, increasing the stability of the oil, such as non-toxicity. Thus, to better exploit the properties of the orange essential oil applied to textile products this study presents a characterization of microcapsules of Melamine formaldehyde obtained by the interfacial polymerization method with variations of proportions of orange oil (volatile) with fixed oil Medium-Chain Triglycerides (MCT) (non-volatile) to assist in the stability of the orange essential oil. Scanning electron microscope (SEM) was used as visualizing tool to characterize microparticles and surface morphology and thermal characteristics of microcapsules were premeditated by mean Differential scanning calorimetry (DSC).

  12. Relevansen af nyere psykodynamisk teori for det klinisk musikterapeutiske arbejde med psykiatriske patienter med personlighedsforstyrrelser

    DEFF Research Database (Denmark)

    Hannibal, Niels

    2007-01-01

    Denne artikel beskriver et rationale for anvendelse af musik i en psykoterapeutisk kontekst. Det eksplicitte og implicitte forandringsniveau i psykoterapi med patienter med borderline-personlighedsforstyrrelse (BPF) diskuteres herpå med henvisning til to forskellige syn på terapeutisk forandring:...

  13. Gruppemusikterapi med patienter med borderline-personlighedsforstyrrelse i dagbehandlingsregi

    Directory of Open Access Journals (Sweden)

    Niels Hannibal

    2008-05-01

    Full Text Available Denne artikel er første redegørelse for de erfaringer, som er gjort med gruppemusikterapi (GMT for patienter med borderline-personlighedsforstyrrelse (BPF i dagbehandlingsregi på Aalborg Psykiatriske Sygehus. Artiklen indeholder både konkrete anvisninger til aktiviteter og interventioner, ligesom den i et teoretisk perspektiv redegør for forskellige processer og reaktioner, der kan iagttages i behandlingen. Artiklen konkluderer, at GMT i sin nuværende form kan bidrage til udvikling af BPF-patienters evne til mentalisering og affektregulering, til opbygning af en gruppefølelse og fremme af interpersonel læring, ligesom GMT kan udvikle alliance til terapi generelt og GMT specifikt.

  14. ORANGE: a Monte Carlo dose engine for radiotherapy

    International Nuclear Information System (INIS)

    Zee, W van der; Hogenbirk, A; Marck, S C van der

    2005-01-01

    This study presents data for the verification of ORANGE, a fast MCNP-based dose engine for radiotherapy treatment planning. In order to verify the new algorithm, it has been benchmarked against DOSXYZ and against measurements. For the benchmarking, first calculations have been done using the ICCR-XIII benchmark. Next, calculations have been done with DOSXYZ and ORANGE in five different phantoms (one homogeneous, two with bone equivalent inserts and two with lung equivalent inserts). The calculations have been done with two mono-energetic photon beams (2 MeV and 6 MeV) and two mono-energetic electron beams (10 MeV and 20 MeV). Comparison of the calculated data (from DOSXYZ and ORANGE) against measurements was possible for a realistic 10 MV photon beam and a realistic 15 MeV electron beam in a homogeneous phantom only. For the comparison of the calculated dose distributions and dose distributions against measurements, the concept of the confidence limit (CL) has been used. This concept reduces the difference between two data sets to a single number, which gives the deviation for 90% of the dose distributions. Using this concept, it was found that ORANGE was always within the statistical bandwidth with DOSXYZ and the measurements. The ICCR-XIII benchmark showed that ORANGE is seven times faster than DOSXYZ, a result comparable with other accelerated Monte Carlo dose systems when no variance reduction is used. As shown for XVMC, using variance reduction techniques has the potential for further acceleration. Using modern computer hardware, this brings the total calculation time for a dose distribution with 1.5% (statistical) accuracy within the clinical range (less then 10 min). This means that ORANGE can be a candidate for a dose engine in radiotherapy treatment planning

  15. Sharing Experience dan Resiliensi: Studi atas Facebook Group Orang Tua Anak Cerebral Palsy

    Directory of Open Access Journals (Sweden)

    Safrina Rofasita

    2017-06-01

    [Orang tua yang mendapati anaknya terfonis sebagai anak Cerebral Palsy mengalami kedukaan mendalam yang mengakibatkan ketidakpercayaan diri, dan putus asa. Hal itu diakibatkan ketahanan terhadap stres (resiliensi rendah, oleh karena itu orang tua mengikuti sharing experiences penyandang Cerebral Palsy melalui Facebook Group orang tua anak Cerebral Palsy. Penelitian ini bertujuan menjawab pertanyaan adakah pengaruh sharing experiences penyandang Cerebral Palsy terhadap resiliensi orang tua anak Cerebral Palsy yang terhimpun dalam Facebook Group Orang Tua Anak Cerebral Palsy. Penelitian menggunakan methode kombinasi antara kuantitatif dan kualitatif. Penelitian menemukan bahwa Facebook Group berpengaruh pada peningkatan resiliensi orang tua anak cerebal palcy karena mereka mendapatkan pengetahuan dan informasi tambahan dari forum itu.

  16. Orange-red emitting Gd2Zr2O7:Sm3+: Structure-property correlation, optical properties and defect spectroscopy

    Science.gov (United States)

    Gupta, Santosh K.; Reghukumar, C.; Sudarshan, K.; Ghosh, P. S.; Pathak, Nimai; Kadam, R. M.

    2018-05-01

    Local structure analysis of dopant ion, understanding host to dopant energy transfer dynamics and defects characterization in a doped material which plays an important role in the designing a highly efficient opto-electronic material. In this connection a new Sm3+ doped Gd2Zr2O7 pyrochlore material was synthesized using gel-combustion technique and was characterized systematically using X-ray diffraction (XRD), time resolved photoluminescence spectroscopy (TRPLS), positron annihilation lifetime spectroscopy (PALS) and density functional theory (DFT) based ab-initio calculation. Based on DFT site selective energetics calculation and luminescence decay measurement, it was observed that the Sm3+ was distributed at both Gd3+ and Zr4+ site with higher Sm3+ fraction at the Gd3+ site. PALS was used to probe the presence of defects in the phosphor. In this work intense orange-red emission is realized through manipulating the energy transfer from host defect emission (oxygen vacancies) to Sm3+ which allows color emission from green in undoped to orange-red in doped samples. Effect of dopant concentration and annealing temperature was probed using TRPLS and PALS. These all information is highly important for researcher looking to achieve pyrochlore based phosphor materials with high quantum yield.

  17. Literacy and Development for the Orang Asli in Malaysia: What Matters?

    Science.gov (United States)

    Renganathan, Sumathi

    2016-01-01

    This article explores the literacy practices of the indigenous Semai Orang Asli community in Malaysia. Literacy for the Orang Asli often centres on formal education and schooling and is hardly explored from a social and cultural perspective. In fact, researchers have paid barely any attention to Orang Asli oral and literate traditions nor their…

  18. Orange juice substantially reduces the bioavailability of the beta-adrenergic-blocking agent celiprolol.

    Science.gov (United States)

    Lilja, Jari J; Juntti-Patinen, Laura; Neuvonen, Pertti J

    2004-03-01

    Grapefruit juice was recently found to decrease plasma concentrations of the beta-adrenergic receptor-blocking agent celiprolol. Our objective was to investigate the effect of orange juice on the pharmacokinetics of celiprolol in healthy subjects. In a randomized crossover study with 2 phases and a washout of 2 weeks, 10 healthy volunteers ingested either 200 mL normal-strength orange juice or water 3 times a day for 2 days. On the morning of day 3, 1 hour after ingestion of 200 mL orange juice or water, each subject ingested 100 mg celiprolol with either 200 mL orange juice or water. In addition, 200 mL orange juice or water was ingested at 4, 10, 22, and 27 hours after celiprolol intake. The concentrations of celiprolol in plasma and its excretion into urine were measured up to 33 hours after its dosing. Systolic and diastolic blood pressures and heart rate were recorded up to 10 hours. Orange juice reduced the mean peak plasma concentration of celiprolol by 89% (P orange juice. Orange juice reduced the urinary excretion of celiprolol by 77% (P Orange juice substantially reduces the bioavailability of celiprolol, but the mechanism of this interaction remains to be resolved. For example, modulation of intestinal pH and of function of transporters implicated in the absorption of celiprolol may be involved. Because of the great extent of the orange juice-celiprolol interaction and a wide use of orange juice, this interaction is likely to have clinical importance in some patients, although hemodynamic consequences were not seen in young healthy subjects.

  19. SegMine workflows for semantic microarray data analysis in Orange4WS

    Directory of Open Access Journals (Sweden)

    Kulovesi Kimmo

    2011-10-01

    Full Text Available Abstract Background In experimental data analysis, bioinformatics researchers increasingly rely on tools that enable the composition and reuse of scientific workflows. The utility of current bioinformatics workflow environments can be significantly increased by offering advanced data mining services as workflow components. Such services can support, for instance, knowledge discovery from diverse distributed data and knowledge sources (such as GO, KEGG, PubMed, and experimental databases. Specifically, cutting-edge data analysis approaches, such as semantic data mining, link discovery, and visualization, have not yet been made available to researchers investigating complex biological datasets. Results We present a new methodology, SegMine, for semantic analysis of microarray data by exploiting general biological knowledge, and a new workflow environment, Orange4WS, with integrated support for web services in which the SegMine methodology is implemented. The SegMine methodology consists of two main steps. First, the semantic subgroup discovery algorithm is used to construct elaborate rules that identify enriched gene sets. Then, a link discovery service is used for the creation and visualization of new biological hypotheses. The utility of SegMine, implemented as a set of workflows in Orange4WS, is demonstrated in two microarray data analysis applications. In the analysis of senescence in human stem cells, the use of SegMine resulted in three novel research hypotheses that could improve understanding of the underlying mechanisms of senescence and identification of candidate marker genes. Conclusions Compared to the available data analysis systems, SegMine offers improved hypothesis generation and data interpretation for bioinformatics in an easy-to-use integrated workflow environment.

  20. MedPAC Data Book

    Data.gov (United States)

    U.S. Department of Health & Human Services — MedPACs Data Book is the result of discussions with congressional staff members regarding ways that MedPAC can better support them. Some of the information it...

  1. The MEDIATOR genes MED12 and MED13 control Arabidopsis root system configuration influencing sugar and auxin responses.

    Science.gov (United States)

    Raya-González, Javier; López-Bucio, Jesús Salvador; Prado-Rodríguez, José Carlos; Ruiz-Herrera, León Francisco; Guevara-García, Ángel Arturo; López-Bucio, José

    2017-09-01

    Arabidopsis med12 and med13 mutants exhibit shoot and root phenotypes related to an altered auxin homeostasis. Sucrose supplementation reactivates both cell division and elongation in primary roots as well as auxin-responsive and stem cell niche gene expression in these mutants. An analysis of primary root growth of WT, med12, aux1-7 and med12 aux1 single and double mutants in response to sucrose and/or N-1-naphthylphthalamic acid (NPA) placed MED12 upstream of auxin transport for the sugar modulation of root growth. The MEDIATOR (MED) complex plays diverse functions in plant development, hormone signaling and biotic and abiotic stress tolerance through coordination of transcription. Here, we performed genetic, developmental, molecular and pharmacological analyses to characterize the role of MED12 and MED13 on the configuration of root architecture and its relationship with auxin and sugar responses. Arabidopsis med12 and med13 single mutants exhibit shoot and root phenotypes consistent with altered auxin homeostasis including altered primary root growth, lateral root development, and root hair elongation. MED12 and MED13 were required for activation of cell division and elongation in primary roots, as well as auxin-responsive and stem cell niche gene expression. Remarkably, most of these mutant phenotypes were rescued by supplying sucrose to the growth medium. The growth response of primary roots of WT, med12, aux1-7 and med12 aux1 single and double mutants to sucrose and application of auxin transport inhibitor N-1-naphthylphthalamic acid (NPA) revealed the correlation of med12 phenotype with the activity of the auxin intake permease and suggests that MED12 acts upstream of AUX1 in the root growth response to sugar. These data provide compelling evidence that MEDIATOR links sugar sensing to auxin transport and distribution during root morphogenesis.

  2. An appreciation of Richard Threlkeld Cox

    Science.gov (United States)

    Tribus, Myron

    2002-05-01

    Richard T. Cox's contributions to the foundations of probability theory and inductive logic are not generally appreciated or understood. This paper reviews his life and accomplishments, especially those in his book The Algebra of Probable Inference and his final publication Inference and Inquiry which, in this author's opinion, has the potential to influence in a significant way the design and analysis of self organizing systems which learn from experience. A simple application to the simulation of a neuron is presented as an example of the power of Cox's contribution.

  3. Orange peel flour effect on physicochemical, textural and sensory properties of cooked sausages

    Directory of Open Access Journals (Sweden)

    Sonia Hernandez Garcia

    2010-06-01

    Full Text Available Orange peel flours as a source of fiber, protein, and flavonoids as antioxidants was added to meat batters in order to improve nutritional quality and physicochemical, textural and sensory properties. Orange peel flour in meat batters improved yield and reduced expressible moisture. Hardness in orange peel flour samples was higher, but less resilient and cohesive. Warner-Bratzler shear force was not different between control (no orange peel flour and samples with this functional ingredient. A no trained panel determinate that there was no difference between control and orange peel flour added sausages at a 5% (w/w level. In this view, orange peel flour can be employed to improve yield and texture of cooked meat products.

  4. Photoluminescence characteristics of Sm{sup 3+} doped Ba{sub 3}La(PO{sub 4}){sub 3} as new orange-red emitting phosphors

    Energy Technology Data Exchange (ETDEWEB)

    Yu, Ruijin [College of Science, Northwest A and F University, Yangling, Shaanxi 712100 (China); Department of Physics, Pukyong National University, Busan 608-737 (Korea, Republic of); Department of Physics, Changwon National University, Changwon 641-773 (Korea, Republic of); Mi Noh, Hyeon; Kee Moon, Byung; Chun Choi, Byung [Department of Physics, Pukyong National University, Busan 608-737 (Korea, Republic of); Hyun Jeong, Jung, E-mail: jhjeong@pknu.ac.kr [Department of Physics, Pukyong National University, Busan 608-737 (Korea, Republic of); Sueb Lee, Ho [Department of Physics, Changwon National University, Changwon 641-773 (Korea, Republic of); Jang, Kiwan, E-mail: kwjang@changwon.ac.kr [Department of Physics, Changwon National University, Changwon 641-773 (Korea, Republic of); Soo Yi, Soung [Department of Electronic Material Engineering, Silla University, Busan 617-736 (Korea, Republic of)

    2014-01-15

    A series of orange-red emitting Ba{sub 3}La(PO{sub 4}){sub 3}:xSm{sup 3+} (0.01≤x≤0.30) phosphors was synthesized by the convenient solid-state reaction. X-ray diffraction and photoluminescence spectra were utilized to characterize the structure and luminescence properties of the as-synthesized phosphors. The emission spectra of the Ba{sub 3}La(PO{sub 4}){sub 3}:Sm{sup 3+} phosphors consisted of some sharp emission peaks of Sm{sup 3+} ions centered at 563 nm, 600 nm, 647 nm, 710 nm. The strongest one is located at 600 nm due to {sup 4}G{sub 5/2}–{sup 6}H{sub 7/2} transition of Sm{sup 3+}, generating bright orange-red light. The optimum dopant concentration of Sm{sup 3+} ions in Ba{sub 3}La(PO{sub 4}):xSm{sup 3+} is around 5 mol% and the critical transfer distance of Sm{sup 3+} is calculated as 22 Å. The CIE chromaticity coordinates of the Ba{sub 3}La(PO{sub 4}){sub 3}:0.05Sm{sup 3+} phosphors was is located in the orange reddish region. The Ba{sub 3}La(PO{sub 4}){sub 3}:Sm{sup 3+} phosphors may be potentially used as red phosphors for white light-emitting diodes. -- Highlights: • A new Sm{sup 3+}-doped Ba{sub 3}La(PO{sub 4}){sub 3} phosphor was firstly synthesized. • Its structure, luminescent properties are well studied and characterized. • The Ba{sub 3}La(PO{sub 4}){sub 3}:Sm{sup 3+} shows bright orange reddish emissions under UV excitation.

  5. COX-2 is associated with periodontitis in Europeans

    NARCIS (Netherlands)

    Schaefer, A.S.; Richter, G.M.; Nothnagel, M.; Laine, M.L.; Noack, B.; Glas, J.; Schrezenmeir, J.; Groessner-Schreiber, B.; Jepsen, S.; Loos, B.G.; Schreiber, S.

    2010-01-01

    COX-2 plays an important role in periodontitis by mediating inflammatory reactions in periodontal tissues, and the COX-2 polymorphisms rs20417 and rs689466 have been reported to be associated with periodontitis in populations of Taiwanese and Chinese ethnicity. To test whether these variants were

  6. Demand relationships in orange exports to Russia: a differential demand system approach focusing on Egypt

    Directory of Open Access Journals (Sweden)

    Assem Abu Hatab

    2016-10-01

    Full Text Available Abstract Recent years have witnessed closer diplomatic relations between Egypt and Russia, which have led to significant growth in the countries’ bilateral agricultural trade. As a world-leading producer and exporter of oranges, these developments represent an opportunity for Egypt to promote its orange exports to Russia. Another emerging opportunity for Egypt to increase its share in the Russian market for imported oranges has been provided by import embargos imposed by Russia in recent years on agricultural and food commodities from several countries, creating a supply gap of around 25 % in the Russian orange market. To assess the competitiveness of Egyptian oranges and explore the potential export opportunities presented by the Russian market, this paper uses a Rotterdam import allocation model to analyse demand relationships among major orange suppliers to Russia during the period 1996–2014. The results show that in comparison with other orange suppliers, Egypt enjoys a strong comparative advantage in the export of oranges to Russia. The econometric results suggest that both Morocco and Egypt would benefit the most if Russia were to allocate a larger budget to the import of oranges. The expenditure elasticity estimates indicate that an increase in Russia’s demand for imported oranges would lead to increases in the quantity of Egypt’s orange exports, as well as in its share of the Russian orange market. Furthermore, cross-price elasticity estimates reveal that Egyptian oranges are substitutes for Turkish and South African oranges, implying that Russia has a tendency to switch to these two suppliers when Egyptian oranges become relatively expensive. In light of these results, the adoption of strategies to produce oranges sustainably and cost-effectively, upgrade the orange value chain, acquire processing technologies and enhance the technical and organisational capacity of farmers and exporters could be useful means for promoting

  7. Leg med vision

    DEFF Research Database (Denmark)

    Munk, Mette; Bertelsen, Katrine

    2011-01-01

    Bogen henvender sig primært til det pædagogiske personale med målgruppen daginstitutioner. Bogen skal stimulere arbejdet med at gøre bevægelse til en integreret del af kulturen i daginstitutioner - at få det pædagogiske personale til - at sætte ord på og spørgsmålstegn ved deres pædagogiske bevæg...

  8. Lærere arbejder med landskabsdannelse

    DEFF Research Database (Denmark)

    2012-01-01

    Valg af materiale/medie/form: YOUtube videoklip. Valg af arbejdsform: Lærere der er igang med at afprøve praktisk undersøgende arbejde med danske landskabsformer. Begrundelse for valg af materiale/medie/form/arbejdsform: Ultrakort videoklip valgt så 1) lærerne kan dele med kolleger, 2) øvrige...

  9. Med Kingo på dybt vand

    DEFF Research Database (Denmark)

    Arndal, Lars Stubbe

    2014-01-01

    Tag med digteren Thomas Kingo ud på dybt vand i selskab med lektor og mag.art. Lars Arndal, der kaster nye perspektiver på Kingos forlisdigt Hierte-Suk. Arndal kommer hermed også med et bud på, hvordan man som lærer kan invitere eleverne med på opdagelse i digtet...

  10. Decoding the Nonvolatile Sensometabolome of Orange Juice ( Citrus sinensis).

    Science.gov (United States)

    Glabasnia, Anneke; Dunkel, Andreas; Frank, Oliver; Hofmann, Thomas

    2018-03-14

    Activity-guided fractionation in combination with the taste dilution analysis, followed by liquid chromatography-tandem mass spectrometry and nuclear magnetic resonance experiments, led to the identification of 10 polymethoxylated flavones (PMFs), 6 limonoid glucosides, and 2 limonoid aglycones as the key bitterns of orange juice. Quantitative studies and calculation of dose-over-threshold factors, followed by taste re-engineering, demonstrated for the first time 25 sensometabolites to be sufficient to reconstruct the typical taste profile of orange juices and indicated that not a single compound can be considered a suitable marker for juice bitterness. Intriguingly, the taste percept of orange juice seems to be created by a rather complex interplay of limonin, limonoid glucosides, PMFs, organic acids, and sugars. For the first time, sub-threshold concentrations of PMFs were shown to enhance the perceived bitterness of limonoids. Moreover, the influence of sugars on the perceived bitterness of limonoids and PMFs in orange juice relevant concentration ranges was quantitatively elucidated.

  11. EFEKTIVITAS AROMATERAPI BITTER ORANGE TERHADAP NYERI POST PARTUM SECTIO CAESAREA

    Directory of Open Access Journals (Sweden)

    Sri Utami

    2016-10-01

    Full Text Available Surgery that causes severe pain physiological response as compared to a normal delivery was called sectio caesarea. The alternative to reduce pain with bitter orange aroma therapy. Bitter orange aroma therapy is to give the effect of reducing the muscle tensions and stress the body as a whole with the goal of keeping the body and mind into a relaxed. This research was aimed to explore the effectiveness of bitter orange aroma therapy for reduction pain in post partum sectio caesarea. The method used this research was quasi experimental with pre test and post test design with control group. The instruments used numeric rating scale to measure pain intensity. The sampling technique used purposive sampling where the quantity of research sample 34 respondents which are divided into 2 groups, namely intervention group and control group. bitter orange aroma therapy carried out for 15 minutes each day for 2 days. The univariate analysis was conducted to show pain distribution and bivariate analysis was conducted by Wicoxon and Mann Whitney. The result show that after bitter orange aroma therapy was applied towards intervered group, it was obtained that mean of respondents category pain was reducing at 3,44 (low pain with the reduction was 1,47 and mean of post partum sectio caesarea pain without given bitter orange aroma therapy in control group was 4,82 (moderate pain with the reduction was 0. The statistic showed up p value (0,000< 0,05 which mean that kneading techniques effective to reduce pain of post partum sectio caesarea. Based on the result, bitter orange aroma therapy can be recommended as nursing intervention of post partum sectio caesarea.

  12. The use of xylenol orange (XO) reagent in molybdenum (MO) analysis

    International Nuclear Information System (INIS)

    Yusuf Nampira; Dian Anggraini

    2012-01-01

    The use of xylenol orange (XO) reagent in the analysis of Molybdenum (Mo) by spectrophotometry have been studied. The aim of this activity is to study the ability of xylenol orange to form a compound of molybdenum-xylenol orange complex to be analyzed by spectrophotometry. Some factors influencing the forming of the complex compound, for instance pH, time, comparison of XO/MO and the amount of Mo, are also studied. The materials used in this research includes ammonium molybdate (NH 4 ) 6 Mo 7 O 24 .4H 2 O), 0,5% xylenol orange and buffer solution (pH 1,5). Measurement result indicates that molybdenum content can be determined by spectrophotometry method at a wavelength of 563,6 nm. The maximum absorbance reached at a ratio of Molybdenum/Xylenol orange 1:2. The concentration of Mo was determined by using law of Lambert Beer, which stayed in the range of 2 ppm to 4 ppm. The stability of complex compound of molybdenum xylenol orange was shorter than 5 minutes. This measurement result can be used as a parameter in the determination of Mo element with UV-VIS spectrophotometer. (author)

  13. Quality of gamma irradiated California Valencia oranges

    International Nuclear Information System (INIS)

    Nagai, N.Y.; Moy, J.H.

    1985-01-01

    The effects of gamma irradiation at 0.30-1.0 kGy (30-100 krad) on sensory qualities, certain biochemical components, and short-term storage life of Valencia oranges were examined. Irradiation at 0.75 kGy maintained food quality during 7°C storage for 7 weeks, while 0.50 kGy irradiation retained food quality at 21 °C. Irradiation at 0.26-0.30 kGy accomplished fruit fly disinfection while preserving market qualities of the oranges

  14. On spatio-temporal Lévy based Cox processes

    DEFF Research Database (Denmark)

    Prokesova, Michaela; Hellmund, Gunnar; Jensen, Eva Bjørn Vedel

    2006-01-01

    The paper discusses a new class of models for spatio-temporal Cox point processes. In these models, the driving field is defined by means of an integral of a weight function with respect to a Lévy basis. The relations to other Cox process models studied previously are discussed and formulas for t...

  15. Gaya Kepemimpinan Orang Buddha Maitreya dalam Bisnis Keluarga

    OpenAIRE

    Josowanto, Selvie

    2014-01-01

    -Penelitian ini bertujuan untuk mengetahui gaya kepemimpinan yang digunakan oleh orang Buddha Maitreya dalam bisnis keluarganya hingga dapat sukses dalam era bisnis, karena mayoritas orang Buddha Maitreya sukses dalam berbisnis. Jenis penelitian ini kualitatif, dengan menggunakan teknik pengumpulan data yaitu wawancara dan observasi pada pemimpin dari USAha berskala menengah dan berskala besar yang merupakan bisnis keluarga, dengan latar belakang agama Buddha Maitreya. Untuk menguji validitas...

  16. Transgenic expression of cyclooxygenase-2 (COX2) causes premature aging phenotypes in mice.

    Science.gov (United States)

    Kim, Joohwee; Vaish, Vivek; Feng, Mingxiao; Field, Kevin; Chatzistamou, Ioulia; Shim, Minsub

    2016-10-07

    Cyclooxygenase (COX) is a key enzyme in the biosynthesis of prostanoids, lipid signaling molecules that regulate various physiological processes. COX2, one of the isoforms of COX, is highly inducible in response to a wide variety of cellular and environmental stresses. Increased COX2 expression is thought to play a role in the pathogenesis of many age-related diseases. COX2 expression is also reported to be increased in the tissues of aged humans and mice, which suggests the involvement of COX2 in the aging process. However, it is not clear whether the increased COX2 expression is causal to or a result of aging. We have now addressed this question by creating an inducible COX2 transgenic mouse model. Here we show that post-natal expression of COX2 led to a panel of aging-related phenotypes. The expression of p16, p53, and phospho-H2AX was increased in the tissues of COX2 transgenic mice. Additionally, adult mouse lung fibroblasts from COX2 transgenic mice exhibited increased expression of the senescence-associated β-galactosidase. Our study reveals that the increased COX2 expression has an impact on the aging process and suggests that modulation of COX2 and its downstream signaling may be an approach for intervention of age-related disorders.

  17. Spectrophotometric determination of aluminium in steel with xylenol orange

    International Nuclear Information System (INIS)

    Majeed, A.; Javed, N.; Khan, M.S.

    1996-01-01

    Spectrophotometric determination of Aluminium in steel based on colour reaction between Aluminium and xylenol orange has been carried out. Red coloured complex formed in weak acidic solution is measured for its absorbance at 550 nm. The various optimum experimental conditions for Aluminium xylenol orange (Al-Xo) complex have been studied. (author)

  18. Determination of rare earth elements by photometric microtitration using xylenol orange

    International Nuclear Information System (INIS)

    Kuban, V.; Jancarova, I.; Sommer, L.

    1989-01-01

    Stock solutions were prepared of rare earth elements in approx 0.1M nitric acid, xylenol orange and EDTA. All measurements were made using a double-beam digital recording spectrophotometer (Superscan 3) with a titration measuring cell with a volume of approx. 30 ml and optical length of 20 mm. Titration agents were pipetted using an automatic piston microburette. Measured were absorbance pH curves of solutions of several lanthanides with xylenol orange, the absorption spectra of solutions of xylenol orange with lanthanides with increasing addition of titration agents EDTA, and the titration curves of the dependence of absorbance of lanthanide solutions with xylenol orange during titration with the EDTA solution. It was found that photometric microtitration allowed accurate and correct determination of all rare earth elements within the concentration range 0.04 - 0.5 mmol/l by titration with standard EDTA solution of a concentration of xylenol orange of 20 μmol/l. (E.S.). 4 figs., 3 tabs., 7 refs

  19. Citric acid production from orange peel wastes by solid-state fermentation

    Directory of Open Access Journals (Sweden)

    Ana María Torrado

    2011-03-01

    Full Text Available Valencia orange (Citrus sinensis peel was employed in this work as raw material for the production of citric acid (CA by solid-state fermentation (SSF of Aspergillus niger CECT-2090 (ATCC 9142, NRRL 599 in Erlenmeyer flasks. To investigate the effects of the main operating variables, the inoculum concentration was varied in the range 0.5·10³ to 0.7·10(8 spores/g dry orange peel, the bed loading from 1.0 to 4.8 g of dry orange peel (corresponding to 35-80 % of the total volume, and the moisture content between 50 and 100 % of the maximum water retention capacity (MWRC of the material. Moreover, additional experiments were done adding methanol or water in different proportions and ways. The optimal conditions for CA production revealed to be an inoculum of 0.5·10(6 spores/g dry orange peel, a bed loading of 1.0 g of dry orange peel, and a humidification pattern of 70 % MWRC at the beginning of the incubation with posterior addition of 0.12 mL H2O/g dry orange peel (corresponding to 3.3 % of the MWRC every 12 h starting from 62 h. The addition of methanol was detrimental for the CA production. Under these conditions, the SSF ensured an effective specific production of CA (193 mg CA/g dry orange peel, corresponding to yields of product on total initial and consumed sugars (glucose, fructose and sucrose of 376 and 383 mg CA/g, respectively. These results, which demonstrate the viability of the CA production by SSF from orange peel without addition of other nutrients, could be of interest to possible, future industrial applications.

  20. Meta-analysis of the association between COX-2 polymorphisms and risk of colorectal cancer based on case-control studies.

    Directory of Open Access Journals (Sweden)

    Qiliu Peng

    Full Text Available OBJECTIVE: Cyclooxygenase-2 (COX-2 is an inducible enzyme converting arachidonic acid to prostaglandins and playing important roles in inflammatory diseases as well as tumor development. Previous studies investigating the association between COX-2 polymorphisms and colorectal cancer (CRC risk reported conflicting results. We performed a meta-analysis of all available studies to explore this association. METHODS: All studies published up to October 2013 on the association between COX-2 polymorphisms and CRC risk were identified by searching electronic databases PubMed, EMBASE, and Cochrane library. The association between COX-2 polymorphisms and CRC risk was assessed by odds ratios (ORs together with their 95% confidence intervals (CIs. RESULTS: Ten studies with 6,774 cases and 9,772 controls were included for -1195A>G polymorphism, 13 studies including 6,807 cases and 10,052 controls were available for -765G>C polymorphism, and 8 studies containing 5,121 cases and 7,487 controls were included for 8473T>C polymorphism. With respect to -765G>C polymorphism, we did not find a significant association with CRC risk when all eligible studies were pooled into the meta-analysis. However, in subgroup analyses by ethnicity and cancer location, with a Bonferroni corrected alpha of 0.05/2, statistical significant increased CRC risk was found in the Asian populations (dominant model CC+CG vs. GG: OR = 1.399, 95%CI: 1.113-1.760, P = 0.004 and rectum cancer patients (CC vs. GG: OR = 2.270, 95%CI: 1.295-3.980, P = 0.004; Recessive model CC vs. CG+GG: OR = 2.269, 95%CI: 1.297-3.970, P = 0.004. In subgroup analysis according to source of control, no significant association was detected. With respect to -1195A>G and 8473T>C polymorphisms, no significant association with CRC risk was demonstrated in the overall and subgroup analyses. CONCLUSIONS: The present meta-analysis suggests that the COX-2 -765G>C polymorphism may be a risk factor for

  1. Study of flavour compounds from orange juices by HS-SPME and GC-MS

    Science.gov (United States)

    Schmutzer, G.; Avram, V.; Covaciu, F.; Feher, I.; Magdas, A.; David, L.; Moldovan, Z.

    2013-11-01

    The flavour of the orange juices, which gives the taste and odour of the product, is an important criterion about the products quality for consumers. A fresh single strength and two commercial orange juices (obtained from concentrate) flavour profile were studied using a selective and sensitive gas chromatography - mass spectrometry (GC-MS) analytical system, after a solvent free, single step preconcentration and extraction technique, the headspace solid phase microextraction (HP-SPME). In the studied orange juices 55 flavour compounds were detected and classified as belonging to the esters, alcohols, ketones, monoterpenes and sesquiterpenes chemical families. The fresh single strength orange juice was characterized by high amount of esters, monoterpenes and sesquiterpenes. Limonene and valencene were the most abundant flavours in this fresh natural orange juice. Alcohols and ketones were found in higher concentration in the commercial orange juices made from concentrate, than in the single strength products. Nevertheless, in commercial juices the most abundant flavour was limonene and α-terpineol. The results highlight clear differences between fresh singles strength orange juice and juice from concentrate. The orange juices reconstructed from concentrate, made in Romania, present low quantity of flavour compounds, suggesting the absence or a low rearomatization process, but extraneous components were not detected.

  2. Double Length Regressions for Testing the Box-Cox Difference Transformation.

    OpenAIRE

    Park, Timothy

    1991-01-01

    The Box-Cox difference transformation is used to determine the appropriate specification for estimation of hedge ratios and a new double length regression form of the Lagrange multiplier test is presented for the difference transformation. The Box-Cox difference transformation allows the testing of the first difference model and the returns model as special cases of the Box-Cox difference transformation. Copyright 1991 by MIT Press.

  3. Aerial Photography and Imagery, Ortho-Corrected - 2012 Digital Orthophotos - Orange County

    Data.gov (United States)

    NSGIC Education | GIS Inventory — This metadata describes the digital orthoimagery covering Orange County, FL. This orthoimagery was collected under contract to the Orange County Property Appraiser...

  4. Peripheral Neuropathy and Agent Orange

    Science.gov (United States)

    ... Enter ZIP code here Enter ZIP code here Peripheral Neuropathy and Agent Orange VA presumes Veterans' early-onset ... 10 percent disabling by VA's rating regulations. About peripheral neuropathy Peripheral neuropathy is a condition of the peripheral ...

  5. Alcoholic fermentation induces melatonin synthesis in orange juice.

    Science.gov (United States)

    Fernández-Pachón, M S; Medina, S; Herrero-Martín, G; Cerrillo, I; Berná, G; Escudero-López, B; Ferreres, F; Martín, F; García-Parrilla, M C; Gil-Izquierdo, A

    2014-01-01

    Melatonin (N-acetyl-5-methoxytryptamine) is a molecule implicated in multiple biological functions. Its level decreases with age, and the intake of foods rich in melatonin has been considered an exogenous source of this important agent. Orange is a natural source of melatonin. Melatonin synthesis occurs during alcoholic fermentation of grapes, malt and pomegranate. The amino acid tryptophan is the precursor of all 5-methoxytryptamines. Indeed, melatonin appears in a shorter time in wines when tryptophan is added before fermentation. The aim of the study was to measure melatonin content during alcoholic fermentation of orange juice and to evaluate the role of the precursor tryptophan. Identification and quantification of melatonin during the alcoholic fermentation of orange juice was carried out by UHPLC-QqQ-MS/MS. Melatonin significantly increased throughout fermentation from day 0 (3.15 ng/mL) until day 15 (21.80 ng/mL) reaching larger amounts with respect to other foods. Melatonin isomer was also analysed, but its content remained stable ranging from 11.59 to 14.18 ng/mL. The enhancement of melatonin occurred mainly in the soluble fraction. Tryptophan levels significantly dropped from 13.80 mg/L (day 0) up to 3.19 mg/L (day 15) during fermentation. Melatonin was inversely and significantly correlated with tryptophan (r = 0.907). Therefore, the enhancement in melatonin could be due to both the occurrence of tryptophan and the new synthesis by yeast. In summary, the enhancement of melatonin in novel fermented orange beverage would improve the health benefits of orange juice by increasing this bioactive compound. © 2013 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

  6. Box-Cox transformation of firm size data in statistical analysis

    Science.gov (United States)

    Chen, Ting Ting; Takaishi, Tetsuya

    2014-03-01

    Firm size data usually do not show the normality that is often assumed in statistical analysis such as regression analysis. In this study we focus on two firm size data: the number of employees and sale. Those data deviate considerably from a normal distribution. To improve the normality of those data we transform them by the Box-Cox transformation with appropriate parameters. The Box-Cox transformation parameters are determined so that the transformed data best show the kurtosis of a normal distribution. It is found that the two firm size data transformed by the Box-Cox transformation show strong linearity. This indicates that the number of employees and sale have the similar property as a firm size indicator. The Box-Cox parameters obtained for the firm size data are found to be very close to zero. In this case the Box-Cox transformations are approximately a log-transformation. This suggests that the firm size data we used are approximately log-normal distributions.

  7. Box-Cox transformation of firm size data in statistical analysis

    International Nuclear Information System (INIS)

    Chen, Ting Ting; Takaishi, Tetsuya

    2014-01-01

    Firm size data usually do not show the normality that is often assumed in statistical analysis such as regression analysis. In this study we focus on two firm size data: the number of employees and sale. Those data deviate considerably from a normal distribution. To improve the normality of those data we transform them by the Box-Cox transformation with appropriate parameters. The Box-Cox transformation parameters are determined so that the transformed data best show the kurtosis of a normal distribution. It is found that the two firm size data transformed by the Box-Cox transformation show strong linearity. This indicates that the number of employees and sale have the similar property as a firm size indicator. The Box-Cox parameters obtained for the firm size data are found to be very close to zero. In this case the Box-Cox transformations are approximately a log-transformation. This suggests that the firm size data we used are approximately log-normal distributions

  8. Predicting a future lifetime through Box-Cox transformation.

    Science.gov (United States)

    Yang, Z

    1999-09-01

    In predicting a future lifetime based on a sample of past lifetimes, the Box-Cox transformation method provides a simple and unified procedure that is shown in this article to meet or often outperform the corresponding frequentist solution in terms of coverage probability and average length of prediction intervals. Kullback-Leibler information and second-order asymptotic expansion are used to justify the Box-Cox procedure. Extensive Monte Carlo simulations are also performed to evaluate the small sample behavior of the procedure. Certain popular lifetime distributions, such as Weibull, inverse Gaussian and Birnbaum-Saunders are served as illustrative examples. One important advantage of the Box-Cox procedure lies in its easy extension to linear model predictions where the exact frequentist solutions are often not available.

  9. Yrkesforberedelse eller fagopplæring med fagbrev? Med design og håndverk som kontekst

    Directory of Open Access Journals (Sweden)

    Bjørn Magne Aakre

    2013-09-01

    Full Text Available Artikkelen drøfter forholdet mellom yrkesforberedelse og fagopplæring med utgangspunkt i den kombinerte studieretningen formgivingsfag som ble innført i Norge i 1994. I 2006 ble den delt i et programfag under studiespesialiserende fag, og et nytt yrkesfaglig program med betegnelse design og håndverk. Hvilke interesser lå til grunn for endringene, hvor dyptgripende ble de og hvilke overveieleser kan en gjøre i ettertid om forholdet mellom yrkesforberedelse og fagopplæring? Artikkelen søker å svare på spørsmålene ut fra relevante dokumenter og to kvantitative undersøkelser med elever og lærere som informanter. Artikkelen konkluderer med at innholdet forble nokså likt, antall elever ble halvert og at frafallet økte. Det konkluderes videre med at mange forhold bidrar til å legitimere et fag og dets innhold som henholdsvis skolefag, vitenskapsfag eller yrkesfag. Legitimeringen preges ofte av motstridende motiver og interesser, og sjelden bare faglige begrunnelser.

  10. Effect of anionic surfactants on the process of Fenton degradation of methyl orange.

    Science.gov (United States)

    Yang, C W; Wang, D

    2009-01-01

    Fenton process has been shown to be very successful to remove dyes from water. However, the influence of other constituents in dyeing industry wastewater, such as Sodium Dodecyl Sulphate (SDS) surfactants, has not been investigated. In this study, the effect of SDS surfactant on the kinetics of Methyl Orange degradation undergoing Fenton process was investigated. Results show that Methyl Orange degradation rate decreased as SDS concentration increased, which was attributed to the consumption of hydroxyl radicals (OH) by surfactants and the formation of Methyl Orange-SDS complex. No evidence was found that the Methyl Orange degradation pathway was affected by the presence of SDS. The kinetics modelling indicates the reaction was the first-order reaction to Methyl Orange.

  11. Redox regulation of the MED28 and MED32 mediator subunits is important for development and senescence.

    Science.gov (United States)

    Shaikhali, Jehad; Davoine, Céline; Björklund, Stefan; Wingsle, Gunnar

    2016-05-01

    Mediator is a conserved multi-protein complex that acts as a bridge between promoter-bound transcriptional regulators and RNA polymerase II. While redox signaling is important in adjusting plant metabolism and development, the involvement of Mediator in redox homeostasis and regulation only recently started to emerge. Our previous results show that the MED10a, MED28, and MED32 Mediator subunits form various types of covalent oligomers linked by intermolecular disulfide bonds in vitro. To link that with biological significance we have characterized Arabidopsis med32 and med28 mutants and found that they are affected in root development and senescence, phenotypes possibly associated to redox changes.

  12. COX-independent mechanisms of cancer chemoprevention by anti-inflammatory drugs

    Directory of Open Access Journals (Sweden)

    Evrim eGurpinar

    2013-07-01

    Full Text Available Epidemiological and clinical studies suggest that non-steroidal anti-inflammatory drugs (NSAIDs, including cyclooxygenase (COX-2 selective inhibitors, reduce the risk of developing cancer. Experimental studies in human cancer cell lines and rodent models of carcinogenesis support these observations by providing strong evidence for the antineoplastic properties of NSAIDs. The involvement of COX-2 in tumorigenesis and its overexpression in various cancer tissues suggest that inhibition of COX-2 is responsible for the chemopreventive efficacy of these agents. However, the precise mechanisms by which NSAIDs exert their antiproliferative effects are still a matter of debate. Numerous other studies have shown that NSAIDs can act through COX-independent mechanisms. This review provides a detailed description of the major COX-independent molecular targets of NSAIDs and discusses how these targets may be involved in their anticancer effects. Toxicities resulting from COX inhibition and the suppression of prostaglandin synthesis preclude the long-term use of NSAIDs for cancer chemoprevention. Furthermore, chemopreventive efficacy is incomplete and treatment often leads to the development of resistance. Identification of alternative NSAID targets and elucidation of the biochemical processes by which they inhibit tumor growth could lead to the development of safer and more efficacious drugs for cancer chemoprevention.

  13. CHANGING PATTERNS OF ORANGE JUICE CONSUMPTION IN THE SOUTHERN UNITED STATES

    OpenAIRE

    Love, Leigh Ann; Sterns, James A.; Spreen, Thomas H.; Wysocki, Allen F.

    2006-01-01

    From 2000 through 2004, per capita orange juice purchases decreased by 12.3 percent while the popularity and media coverage of low-carbohydrate dieting exploded. Content analysis was used to count selected Southern region newspaper articles topically related to low-carbohydrate dieting, the Atkins diet, and the South Beach diet. This data was included in a Southern region orange juice demand model, where purchase data served as the independent variable and proxy for consumer demand of orange ...

  14. Influence of Immigration on Epiphytic Bacterial Populations on Navel Orange Leaves

    OpenAIRE

    Lindow, S. E.; Andersen, G. L.

    1996-01-01

    Factors that influenced the increase in epiphytic bacterial population size on navel orange leaves during winter months were investigated to test the assumption that such populations were the result of multiplication on orange leaves. The population sizes of bacteria of different kinds, including ice nucleation-active (Ice(sup+)) bacteria, were from 6- to 30-fold larger on leaves of navel orange trees adjacent to other plant species than on trees growing near other citrus species. Total and I...

  15. CoX zeolites and their exchange with deuterium

    Energy Technology Data Exchange (ETDEWEB)

    Novakova, J; Kubelkova, L; Jiru, P [Ceskoslovenska Akademie Ved, Prague. Ustav Fyzikalni Chemie

    1976-04-01

    An analysis of the gaseous phase using a mass spectrometer and analysis of the solid phase using an infrared spectrophotometer was made to investigate the deuterium exchange with hydrogen mostly bound in hydroxyl groups of zeolites CoX(21 and 47%) and NaX. It was found that with the increasing amount of cobalt ions the number of exchangeable hydrogens of the zeolite increases; the respective types of the hydrogen are discussed with respect to the particular dehydration temperatures. The rate of the D/sub 2/+OH exchange is substantially faster with the CoX than with the NaX zeolite, and exhibits a decrease with increasing dehydration. On the other hand, the rate of D/sub 2/+H/sub 2/ exchange without zeolite hydrogen incorporation, catalyzed by CoX zeolites, increases with increasing dehydration. The increased activation of gaseous hydrogen molecules is related to the presence in the zeolite of cobalt ions whose properties change during dehydration with the change in their environment. Hydroxyl groups of the CoX zeolites are not equivalent during the exchange; the hydroxyl hydrogens of the 3740 cm/sup -1/ band are exchanged more slowly than are the other hydrogens.

  16. CoX zeolites and their exchange with deuterium

    International Nuclear Information System (INIS)

    Novakova, J.; Kubelkova, L.; Jiru, P.

    1976-01-01

    An analysis of the gaseous phase using a mass spectrometer and analysis of the solid phase using an infrared spectrophotometer was made to investigate the deuterium exchange with hydrogen mostly bound in hydroxyl groups of zeolites CoX(21 and 47%) and NaX. It was found that with the increasing amount of cobalt ions the number of exchangeable hydrogens of the zeolite increases; the respective types of the hydrogen are discussed with respect to the particular dehydration temperatures. The rate of the D 2 +OH exchange is substantially faster with the CoX than with the NaX zeolite, and exhibits a decrease with increasing dehydration. On the other hand, the rate of D 2 +H 2 exchange without zeolite hydrogen incorporation, catalyzed by CoX zeolites, increases with increasing dehydration. The increased activation of gaseous hydrogen molecules is related to the presence in the zeolite of cobalt ions whose properties change during dehydration with the change in their environment. Hydroxyl groups of the CoX zeolites are not equivalent during the exchange; the hydroxyl hydrogens of the 3740 cm -1 band are exchanged more slowly than are the other hydrogens. (author)

  17. Biodegradation of orange G by a novel isolated bacterial strain ...

    African Journals Online (AJOL)

    At these optimum levels of parameters, bacterial decolorization of orange G by 94.48% was obtained under static conditions. Biodegradation and decolorization of azo dye, orange G, was confirmed using UV-VIS spectrophotometry, thin layer chromatography (TLC) and fourier transform infrared spectroscopy (FTIR) and ...

  18. DailyMed

    Data.gov (United States)

    U.S. Department of Health & Human Services — DailyMed provides high quality information about marketed drugs. This information includes FDA labels (package inserts). This Web site provides health information...

  19. THE PRODUCTION OF ORANGE PRESS LIQUOR SPIRIT: TECHNICAL AND ECONOMIC ASPECTS

    Directory of Open Access Journals (Sweden)

    J. O. FERREIRA

    2008-10-01

    Full Text Available

    The orange juice industry produces, at the end of the residue extraction, a by-product called orange press liquor. Considering its high content of soluble solids and the large volume of the liquor produced in Brazilian orange juice plants, an earlier study was conducted on the technical viability of using orange press liquor as raw material for a new distilled beverage, with promising results. With a view to increasing efficiency and possibly attracting investments in the growing international market for new and exotic beverages, the aim of the present study was to optimize the orange press liquor spirit process and to evaluate the economic aspects of its production. The results showed that this process can yield a good quality beverage, comparable to the sugar cane spirit cachaça and other similar products, as well as having economic advantages and potential for immediate further growth, without extra investment costs.

  20. Detection of 8-hydroxydeoxyguanine in the Irradiated Orange and Spice

    International Nuclear Information System (INIS)

    Alam, Mohammad Khorshed.

    2007-01-01

    A study was carried out to detect the chemical change that might occur in irradiated orange and spice. Oxidative DNA damage can induce the production of 8-hydroxydeoxyguanine (8-OHdG) and thus the level of 8-hydroxydeoxyguanine was investigated using enzyme linked immunosorbent assay (ELISA) in the irradiated orange and spice which was compared with the unirradiated samples. By the difference in the oxidized guanine level that produce 8-hydroxydeoxyguanine in the irradiated and unirradiated samples, it can be clearly understood that detection of irradiated orange and spice is possible using monoclonal antibody for 8-hydroxydeoxyguanine in the ELAISA assay.(author)

  1. MANUAL FOR PROCESORIENTERET MUSIKTERAPI MED PERSONER MED BPD.

    Directory of Open Access Journals (Sweden)

    Niels Hannibal

    2010-12-01

    Full Text Available Denne artikel introducerer et musikterapeutisk behandlingskoncept kaldet: Procesorienteret Musikterapi (PROM. PROM er et forsøg på at formulere en principiel ramme for musikterapi i psykiatrien, som dels tager udgangspunkt i 17 års klinisk erfaring, dels stiler mod at være ”best practice”. PROM indeholder beskrivelser af manualens unikke, essentielle men ikke unikke, acceptable og ikke acceptable dele. Den unikke del af PROM skal kunne implementeres til alle målgrupper, mens de øvrige dele af manualen rettes til i forhold til en specifik målgruppe. Denne udgave af PROM er specifikt rettet i mod musikterapi for patienter med personlighedsforstyrrelser. Manualen indgår også som en del af et pilotprojekt, der har til formål at udvikle en protokol for et internationalt RCT projekt med samme målgruppe

  2. COX-2 rs689466, rs5275, and rs20417 polymorphisms and risk of head and neck squamous cell carcinoma: a meta-analysis of adjusted and unadjusted data

    International Nuclear Information System (INIS)

    Leng, Wei-Dong; Wen, Xiu-Jie; Kwong, Joey S. W.; Huang, Wei; Chen, Jian-Gang; Zeng, Xian-Tao

    2016-01-01

    Numerous case–control studies have been performed to investigate the association between three cyclooxygenase-2 (COX-2) polymorphisms (rs20417 (−765G > C), rs689466 (−1195G > A), and rs5275 (8473 T > C)) and the risk of head and neck squamous cell carcinoma (HNSCC). However, the results were inconsistent. Therefore, we conducted this meta-analysis to investigate the association. We searched in PubMed, Embase, and Web of Science up to January 20, 2015 (last updated on May 12, 2016). Two independent reviewers extracted the data. Odds ratios (ORs) with their 95 % confidence intervals (CIs) were used to assess the association. All statistical analyses were performed using the Review Manager (RevMan) 5.2 software. Finally 8 case–control studies were included in this meta-analysis. For unadjusted data, an association with increased risk was observed in three genetic models in COX-2 rs689466 polymorphism; however, COX-2 rs5275 and rs20417 polymorphisms were not related to HNSCC risk in this study. The pooled results from adjusted data all revealed non-significant association between these three polymorphisms and risk of HNSCC. We also found a similar result in the subgroup analyses, based on both unadjusted data and adjusted data. Current results suggest that COX-2 rs689466, rs5275, and rs20417 polymorphisms are not associated with HNSCC. Further large and well-designed studies are necessary to validate this association

  3. Sociale indsatser til mennesker med ADHD

    DEFF Research Database (Denmark)

    Bengtsson, Steen; Alim, Winnie; Holmskov, Henriette

    Igennem de seneste år har flere og flere fået stillet diagnosen ADHD, som er en adfærdsmæssig forstyrrelse. Mennesker med ADHD har meget forskelligt støttebehov, og rapportens formål er at skabe overblik over de eksisterende sociale indsatser og tilbud til børn, unge og voksne med ADHD. Langt de...... ansvar for sociale end for terapeutiske tilbud i forhold til gruppen med ADHD. Mange voksne med ADHD beskriver, at det kræver mange ressourcer at få den fornødne støtte fra kommunen, mens forældre til børn med ADHD oplever det som nemmere at få adgang til de rette støttetilbud. Men begge grupper møder...... mange udfordringer som fx manglende koordinering og hyppige sagsbehandlerskift. Rapporten er udarbejdet i tilknytning til Servicestyrelsens projekt ’Ny og forstærket indsats til børn, unge og voksne med ADHD’ og er finansieret af Socialministeriet....

  4. Extensions and Applications of the Cox-Aalen Survival Model

    DEFF Research Database (Denmark)

    Scheike, Thomas H.; Zhang, Mei-Jie

    2003-01-01

    Aalen additive risk model; competing risk; counting processes; Cox model; cumulative incidence function; goodness of fit; prediction of survival probability; time-varying effects......Aalen additive risk model; competing risk; counting processes; Cox model; cumulative incidence function; goodness of fit; prediction of survival probability; time-varying effects...

  5. The preservative potentials of sweet orange seed oil on leather ...

    African Journals Online (AJOL)

    Orange seed oil was extracted using the steam distillation method. The fungi isolated from the leather samples were Aspergillus niger, Aspergillus fumigatus, Aspergillus flavus, Paecilomyces sp., Penicillium sp., Rhizopus nigricans and Alternaria sp. However, the fungal species vary from person to person. The orange seed ...

  6. Oranges and Sunshine: The Story of a Traumatic Encounter

    Directory of Open Access Journals (Sweden)

    Dolores Herrero

    2015-10-01

    Full Text Available This paper will rely on some well-known theories on trauma, memory and ethics to study how Jim Loach’s debut film Oranges and Sunshine (2010 testifies to the traumatic deportation of up to 150,000 British children to distant parts of the Empire, mainly Australia, until 1970. Oranges and Sunshine was based on Margaret Humphreys’ moving memoir, originally entitled Empty Cradles (1994 but later re-titled Oranges and Sunshine after Loach’s film. What these two texts basically claim is the need to recover historic memory through heart-breaking acts of remembrance, which can alone denounce the atrocities that were concomitant with the colonial enterprise and pave the way for disclosing and working through individual and collective traumas.

  7. PubMed

    Data.gov (United States)

    U.S. Department of Health & Human Services — PubMed comprises more than 26 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to...

  8. PubMed

    CERN Document Server

    PubMed is the National Library of Medicine's search service that provides access to over 10 million citations in MEDLINE, PreMEDLINE, and other related databases, with links to participating online journals.

  9. DPPC regulates COX-2 expression in monocytes via phosphorylation of CREB

    International Nuclear Information System (INIS)

    Morris, R.H.K.; Tonks, A.J.; Jones, K.P.; Ahluwalia, M.K.; Thomas, A.W.; Tonks, A.; Jackson, S.K.

    2008-01-01

    The major phospholipid in pulmonary surfactant dipalmitoyl phosphatidylcholine (DPPC) has been shown to modulate inflammatory responses. Using human monocytes, this study demonstrates that DPPC significantly increased PGE 2 (P < 0.05) production by 2.5-fold when compared to untreated monocyte controls. Mechanistically, this effect was concomitant with an increase in COX-2 expression which was abrogated in the presence of a COX-2 inhibitor. The regulation of COX-2 expression was independent of NF-κB activity. Further, DPPC increased the phosphorylation of the cyclic AMP response element binding protein (CREB; an important nuclear transcription factor important in regulating COX-2 expression). In addition, we also show that changing the fatty acid groups of PC (e.g. using L-α-phosphatidylcholine β-arachidonoyl-γ-palmitoyl (PAPC)) has a profound effect on the regulation of COX-2 expression and CREB activation. This study provides new evidence for the anti-inflammatory activity of DPPC and that this activity is at least in part mediated via CREB activation of COX-2

  10. Praktische handleiding PubMed : hét boek om snel en doeltreffend te zoeken in PubMed

    NARCIS (Netherlands)

    Etten-Jamaludin, van F.; Deurenberg, H.W.J.

    2010-01-01

    Praktische handleidng PubMed is de eerste Nederlandstalige gids die op overzichtelijke wijze op de uitgebreide mogelijkheden van PubMed ingaat. PubMed (www.pubmed.gov) biedt gratis toegang tot MEDLINE en is de meest gebruikte medische zoekmachine. In deze geheel herziene derde editie van Praktisch

  11. Generalised shot noise Cox processes

    DEFF Research Database (Denmark)

    Møller, Jesper; Torrisi, Giovanni Luca

    We introduce a new class of Cox cluster processes called generalised shot-noise processes (GSNCPs), which extends the definition of shot noise Cox processes (SNCPs) in two directions: the point process which drives the shot noise is not necessarily Poisson, and the kernel of the shot noise can...... be random. Thereby a very large class of models for aggregated or clustered point patterns is obtained. Due to the structure of GSNCPs, a number of useful results can be established. We focus first on deriving summary statistics for GSNCPs and next on how to make simulation for GSNCPs. Particularly, results...... for first and second order moment measures, reduced Palm distributions, the -function, simulation with or without edge effects, and conditional simulation of the intensity function driving a GSNCP are given. Our results are exemplified for special important cases of GSNCPs, and we discuss the relation...

  12. Educating the Orang Asli Children: Exploring Indigenous Children's Practices and Experiences in Schools

    Science.gov (United States)

    Renganathan, Sumathi

    2016-01-01

    The author is concerned with the education available for the Orang Asli, an indigenous minority community in Malaysia. Literature written about Orang Asli and education mostly assumes a deficit perspective where the lack of educational achievement among the Orang Asli children is often attributed to their culture and community. Therefore, rather…

  13. Surficial sediments of the wave-dominated Orange River Delta and ...

    African Journals Online (AJOL)

    The textural and compositional characteristics of the surficial shelf sediments north and south of the Orange River Delta are reviewed and compared. Sediments are fractionated and dispersed both north- and southwards of the Orange River mouth by wave action, longshore drift and subsurface currents. The mean grain ...

  14. Exploring selectivity requirements for COX-2 versus COX-1 binding of 2-(5-phenyl-pyrazol-1-yl)-5-methanesulfonylpyridines using topological and physico-chemical parameters.

    Science.gov (United States)

    Chakraborty, Santanu; Sengupta, Chandana; Roy, Kunal

    2005-04-01

    Considering the current need for development of selective cyclooxygenase-2 (COX-2) inhibitors, an attempt has been made to explore physico-chemical requirements of 2-(5-phenyl-pyrazol-1-yl)-5-methanesulfonylpyridines for binding with COX-1 and COX-2 enzyme subtypes and also to explore the selectivity requirements. In this study, E-states of different common atoms of the molecules (calculated according to Kier & Hall), first order valence connectivity and physicochemical parameters (hydrophobicity pi, Hammett sigma and molar refractivity MR of different ring substituents) were used as independent variables along with suitable dummy parameters in the stepwise regression method. The best equation describing COX-1 binding affinity [n = 25, Q2 = 0.606, R(a)2 = 0.702, R2 = 0.752, R = 0.867, s = 0.447, F = 15.2 (df 4, 20)] suggests that the COX-1 binding affinity increases in the presence of a halogen substituent at R1 position and a p-alkoxy or p-methylthio substituent at R2 position. Furthermore, a difluoromethyl group is preferred over a trifluoromethyl group at R position for the COX-1 binding. The best equation describing COX-2 binding affinity [n = 32, Q2 = 0.622, R(a)2= 0.692, R2 = 0.732, R = 0.856, s = 0.265, F = 18.4 (df 4, 27)] shows that the COX-2 binding affinity increases with the presence of a halogen substituent at R1 position and increase of size of R2 substituents. However, it decreases in case of simultaneous presence of 3-chloro and 4-methoxy groups on the phenyl nucleus and in the presence of highly lipophilic R2 substituents. The best selectivity relation [n = 25, Q2 = 0.455, R(a)2 = 0.605, R2 = 0.670, R = 0.819, s = 0.423, F = 10.2 (df 4, 20)] suggests that the COX-2 selectivity decreases in the presence of p-alkoxy group and electron-withdrawing para substituents at R2 position. Again, a trifluoro group is conductive for the selectivity instead of a difluoromethyl group at R position. Furthermore, branching may also play significant role in

  15. Gamma radiation and the conservation of natural orange juice

    International Nuclear Information System (INIS)

    Iemma, Juliana; Alcarde, Andre Ricardo; Domarco, Rachel Elisabeth; Spoto, Marta Helena Fillet; Blumer, Lucimara; Matraia, Clarice

    1999-01-01

    The effect of gamma radiation was evaluated on the microbiological population, soluble solids content, acidity, p H and ascorbic acid content of natural orange juice. Microbial activity may cause deterioration of orange juice. Irradiation is a process of food conservation which eliminates microorganisms. nevertheless radiation may affect some characteristics of irradiated food. The experimental design was a 4 x 5 factorial scheme, including control and 3 rates of irradiation (2.0, 4.0 and 6.0 kGy) and 5 storage periods (1, 7, 14, 21 and 28 days), with 2 replicates. Samples of juice were extracted from variety Pera oranges and irradiated at a rate of 2.0 kGy/h ( 60 Cobalt) and thereafter stored at 5 +- 3 deg C. Results showed small changes in soluble solids content, acidity and p H, for all treatments. The ratio soluble solids/acidity was also determined and showed little variation for all treatments. There was a reduction on ascorbic acid content of the orange juice with increased radiation dosage and storage time. Gamma radiation was effective in reducing the microbiological population of the juice. (author)

  16. Towards PubMed 2.0.

    Science.gov (United States)

    Fiorini, Nicolas; Lipman, David J; Lu, Zhiyong

    2017-10-30

    Staff from the National Center for Biotechnology Information in the US describe recent improvements to the PubMed search engine and outline plans for the future, including a new experimental site called PubMed Labs.

  17. Orange and reddish-orange light emitting phosphors: Sm{sup 3+} and Sm{sup 3+}/Eu{sup 3+} doped zinc phosphate glasses

    Energy Technology Data Exchange (ETDEWEB)

    Meza-Rocha, A.N., E-mail: ameza@fis.cinvestav.mx [Departamento de Física, Universidad Autónoma Metropolitana-Iztapalapa, P.O. Box 55-534, 09340 México D.F., México (Mexico); Speghini, A. [Dipartimento di Biotecnologie, Universita di Verona and INSTM, UdR Verona, Strada Le Grazie 15, I-37314 Verona (Italy); IFAC CNR, Nello Carrara Institute of Applied Physics, MDF Lab, I-50019 Sesto Fiorentino, FI (Italy); Bettinelli, M. [Dipartimento di Biotecnologie, Universita di Verona and INSTM, UdR Verona, Strada Le Grazie 15, I-37314 Verona (Italy); Caldiño, U. [Departamento de Física, Universidad Autónoma Metropolitana-Iztapalapa, P.O. Box 55-534, 09340 México D.F., México (Mexico)

    2015-11-15

    A spectroscopy study of Sm{sup 3+} and Sm{sup 3+}/Eu{sup 3+} doped zinc phosphate glasses is performed through photoluminescence spectra and decay time profile measurements. Under Sm{sup 3+} excitation at 344 nm, the Sm{sup 3+} singly doped glass shows an orange global emission with x=0.579 and y=0.414 CIE1931 chromaticity coordinates, whereas the Sm{sup 3+}/Eu{sup 3+} co-doped sample exhibits orange overall emissions (x=0.581 and y=0.398, and x=0.595 and y=0.387) and reddish-orange overall emission (x=0.634 and y=0.355) upon excitations at 344, 360 and 393 nm, respectively. Such luminescence from the co-doped sample is originated by the simultaneous emission of Sm{sup 3+} and Eu{sup 3+}. Under Sm{sup 3+} excitation at 344 and 360 nm, the Eu{sup 3+} emission is sensitized and enhanced by Sm{sup 3+} through a non-radiative energy transfer process. The non-radiative nature was inferred from the shortening of the Sm{sup 3+} lifetime observed in the Sm{sup 3+}/Eu{sup 3+} co-doped sample. An analysis of the Sm{sup 3+} emission decay time profiles using the Inokuti–Hirayama model suggests that an electric quadrupole–quadrupole interaction into Sm–Eu clusters might dominate the energy transfer process, with an efficiency of 0.17. - Highlights: • Zinc phosphate glasses are optically activated with Sm{sup 3+}/Eu{sup 3+} (ZPOSmEu). • Non-radiative energy transfer Sm{sup 3+}→Eu{sup 3+} takes place in ZPOSmEu. • ZPOSmEu overall emission can be modulated with the excitation wavelength. • ZPOSmEu might be useful as orange/reddish-orange phosphor for UV-white LEDs.

  18. Endostatin (EntreMed).

    Science.gov (United States)

    Grosios, K

    2000-07-01

    EntreMed has licensed the worldwide rights to the angiogenesis inhibitor Endostatin, a 20 kDa C-terminal fragment of collagen XVIII, from the Children's Hospital of Boston, a teaching affiliate of Harvard Medical School. It is being developed as a potential cancer treatment and may also be useful in certain types of blindness and arthritis [227427]. EntreMed filed an IND for Endostatin in June 1999 [334125] and as of September 1999, phase I trials were underway [341462]. As of April 2000, the company had initiated plans for testing low doses of Endostatin in cancer patients using continuous infusion and sc administration in a further phase I study to be conducted in Europe [361594]. A phase I trial of Endostatin which will evaluate the safety and efficacy of Endostatin at a range of doses in no more than 100 cancer patients has been initiated. The trial will take place at the University of Texas MD Anderson Medical Center and the University of Wisconsin Cancer Center in Madison. The National Cancer Center will be sponsoring the trial, which is expected to be completed in late 2000. As of March 2000, there had been no serious adverse events attributable to Endostatin administration. The first report from this trial is expected in autumn 2000 [341462], [366312]. The mechanism of action for Endostatin remains unclear, although reports from the 91st AACR Meeting in April 2000 showed that recombinant human endostatin bound to a number of tropomyosin cDNAs in a library screen [362039]. In preclinical studies, repeated administration of Endostatin consistently shrank primary tumors and did not produce any drug resistance. In mice, a variety of tumors which had progressed to 1 to 2% of total body weight, regressed to microscopic, dormant lesions following Endostatin treatment [231418], [231470], [270673]. Types of cancers which respond to Endostatin include lung, skin, vascular and fibrosarcomas. Toxicology studies in cynomolgus monkeys showed that bolus injections of

  19. Nucleobindin co-localizes and associates with cyclooxygenase (COX-2 in human neutrophils.

    Directory of Open Access Journals (Sweden)

    Patrick Leclerc

    2008-05-01

    Full Text Available The inducible cyclooxygenase isoform (COX-2 is associated with inflammation, tumorigenesis, as well as with physiological events. Despite efforts deployed in order to understand the biology of this multi-faceted enzyme, much remains to be understood. Nucleobindin (Nuc, a ubiquitous Ca(2+-binding protein, possesses a putative COX-binding domain. In this study, we investigated its expression and subcellular localization in human neutrophils, its affinity for COX-2 as well as its possible impact on PGE(2 biosynthesis. Complementary subcellular localization approaches including nitrogen cavitation coupled to Percoll fractionation, immunofluorescence, confocal and electron microscopy collectively placed Nuc, COX-2, and all of the main enzymes involved in prostanoid synthesis, in the Golgi apparatus and endoplasmic reticulum of human neutrophils. Immunoprecipitation experiments indicated a high affinity between Nuc and COX-2. Addition of human recombinant (hr Nuc to purified hrCOX-2 dose-dependently caused an increase in PGE(2 biosynthesis in response to arachidonic acid. Co-incubation of Nuc with COX-2-expressing neutrophil lysates also increased their capacity to produce PGE(2. Moreover, neutrophil transfection with hrNuc specifically enhanced PGE(2 biosynthesis. Together, these results identify a COX-2-associated protein which may have an impact in prostanoid biosynthesis.

  20. Veterans and agent orange: update 2000

    National Research Council Canada - National Science Library

    Committee to Review the Health Effects in Vietnam Veterans of Exposure to Herbicides (Third Biennial Update), Division of Health Promotion and Disease Prevention

    2001-01-01

    Veterans and Agent Orange: Update 2000 examines the state of the scientific evidence regarding associations between diseases and exposure to dioxin and other chemical compounds in herbicides used in Vietnam...

  1. Pampas Grass - Orange Co. [ds351

    Data.gov (United States)

    California Natural Resource Agency — This dataset provides the known distribution of pampas grass (Cortaderia selloana) in southern Orange County. The surveys were conducted from May to June, 2007 and...

  2. Trifoliate hybrids as rootstocks for Pêra sweet orange tree

    Directory of Open Access Journals (Sweden)

    Jorgino Pompeu Junior

    2014-03-01

    Full Text Available The Rangpur lime (Citrus limonia has been used as the main rootstock for Pêra sweet orange (C. sinensis trees. However, its susceptibility to citrus blight and citrus sudden death has led to the use of disease-tolerant rootstocks, such as Cleopatra mandarin reshni, Sunki mandarin (C. sunki and Swingle citrumelo (C. paradisi x Poncirus trifoliata, which are more susceptible to drought than the Rangpur lime. These mandarin varieties are also less resistant to root rot caused by Phytophthora, and the Swingle citrumelo showed to be incompatible with the Pêra sweet orange. In search of new rootstock varieties, this study aimed at assessing the fruit precocity and yield, susceptibility to tristeza and blight and occurrence of incompatibility of Pêra sweet orange trees grafted on 12 trifoliate hybrids, on Rangpur lime EEL and Goutou sour orange, without irrigation. Tristeza and blight are endemic in the experimental area. The Sunki x English (1628 and Changsha x English Small (1710 citrandarins and two other selections of Cleopatra x Rubidoux provided the highest cumulative yields, in the first three crops and in the total of six crops evaluated. The Cleopatra x Rubidoux (1660 and Sunki x Benecke (1697 citrandarins induced early yield, while the Cravo x Swingle citromonia and C-13 citrange induced later yield. None of the rootstock varieties caused alternate bearing. Pêra sweet orange trees grafted on Swingle citrumelo, Cleopatra x Swingle (1654 citrandarin and on two selections of Rangpur lime x Carrizo citrange showed bud-union-ring symptoms of incompatibility. None of the plants presented symptoms of tristeza or blight.

  3. Citrus sinensis annotation project (CAP): a comprehensive database for sweet orange genome.

    Science.gov (United States)

    Wang, Jia; Chen, Dijun; Lei, Yang; Chang, Ji-Wei; Hao, Bao-Hai; Xing, Feng; Li, Sen; Xu, Qiang; Deng, Xiu-Xin; Chen, Ling-Ling

    2014-01-01

    Citrus is one of the most important and widely grown fruit crop with global production ranking firstly among all the fruit crops in the world. Sweet orange accounts for more than half of the Citrus production both in fresh fruit and processed juice. We have sequenced the draft genome of a double-haploid sweet orange (C. sinensis cv. Valencia), and constructed the Citrus sinensis annotation project (CAP) to store and visualize the sequenced genomic and transcriptome data. CAP provides GBrowse-based organization of sweet orange genomic data, which integrates ab initio gene prediction, EST, RNA-seq and RNA-paired end tag (RNA-PET) evidence-based gene annotation. Furthermore, we provide a user-friendly web interface to show the predicted protein-protein interactions (PPIs) and metabolic pathways in sweet orange. CAP provides comprehensive information beneficial to the researchers of sweet orange and other woody plants, which is freely available at http://citrus.hzau.edu.cn/.

  4. Reduction of the waste from domestic production of the orange

    International Nuclear Information System (INIS)

    Husain, K. A. M.

    2010-10-01

    The research subject is (reduction of the waste from domestic production of orange) we find there is a lot of wastage after harvest, because the process of packaging, loading, transportation, and store is not adequate. The purpose of this research is to solve this problem of wastage by following a number of steps after harvesting and pre-harvest process. This process is called COLD CHAIN. Cold chain is: cold store in production place, cold vehicles for transportation, cold room in the market, cold car for distribution, cold and freezer refrigerator home. After adopting the cold chain we achieved the following results: orange wastage is reduced, the orange quality improved. (Author)

  5. Hvordan er det å leve med CRPS?

    OpenAIRE

    Hovind, Thomas

    2014-01-01

    Hensikten med denne studien er å se på hvordan pasienter med komplekst regionalt smertesyndrom (CRPS) opplever å leve med tilstanden og hvordan disse pasientene har opplevd å bli møtt i helsevesenet. CRPS er en langvarig tilstand med sterke smerter som kan medføre økt smerterespons, redusert funksjon og nedsatt livskvalitet hos pasientene. Studien er en kvalitativ undersøkelse basert på dybdeintervju av fire pasienter med CRPS. Pasientene ble rekruttert fra en smerteavdeling i Nord-Norge og u...

  6. The MedCLIVAR Network

    Science.gov (United States)

    Lionello, Piero; Medclivar sg, The

    2013-04-01

    The MedCLIVAR initiative was first proposed at the 2003 European Geosciences Union assembly in Nice, France. In 2005, it was endorsed by the International Climate Variability and Predictability (CLIVAR) office. Subsequently, the MedCLIVAR Research Network Project was formally approved by the European Science Foundation and launched in May 2006 with the support of funding agencies from 12 countries. Since then, MedCLIVAR has served as a scientific network to promote interaction among different scientific disciplines and to develop a multidisciplinary vision of the evolution of the Mediterranean climate through studies that integrate atmospheric, marine, and terrestrial climate components at time scales ranging from paleoreconstructions to future climate scenarios. Presently, the network continues dealing with scientific issues including past climate variability; connections between the Mediterranean and global climate; the Mediterranean Sea circulation and sea level; feedbacks on the global climate system; and regional responses to greenhouse gas, air pollution, and aerosols. Its present activities include the publication of a newsletter, the organization of the next MedCLIVAR conference in 2014 and the publication of a special issue of Regional Environmental Change devoted to the climate of the Mediterranean region.

  7. The CaO orange system in meteor spectra

    Science.gov (United States)

    Berezhnoy, A. A.; Borovička, J.; Santos, J.; Rivas-Silva, J. F.; Sandoval, L.; Stolyarov, A. V.; Palma, A.

    2018-02-01

    The CaO orange band system was simulated in the region 5900-6300 Å and compared with the experimentally observed spectra of Benešov bolide wake. The required vibronic Einstein emission coefficients were estimated by means of the experimental radiative lifetimes under the simplest Franck-Condon approximation. A moderate agreement was achieved, and the largest uncertainties come from modeling shape of FeO orange bands. Using a simple model the CaO column density in the wake of the Benešov bolide at the height of 29 km was estimated as (5 ± 2) × 1014 cm-2 by a comparison of the present CaO spectra with the AlO bands nicely observed at 4600-5200 Å in the same spectrum. The obtained CaO content is in a good agreement with the quenching model developed for the impact-produced cloud, although future theoretical and experimental studies of both CaO and FeO orange systems contribution would be needed to confirm these results.

  8. Absence of furanocoumarins in Advantra Z® (Citrus aurantium, bitter orange) extracts.

    Science.gov (United States)

    Stohs, Sidney J; Miller, Howard; Romano, Felice

    2014-09-01

    Grapefruit (Citrus paradisi) juice is known for its ability to alter drug metabolism through inhibition of the cytochrome P450-3A4 (CYP3A4) system, and result in drug-food interactions that may be life threatening. The primary active ingredients in grapefruit responsible for these effects are the furanocoumarins bergapten, bergamottin, and 6',7'-dihydroxybergamottin (DHB). Bergamottin and DHB appear to be the most important in terms of adverse drug interactions. Furanocoumarins are present in the juices and fruits of other Citrus species including C. aurantium (bitter oranges). Bergapten is the predominant furanocoumarin in bitter orange. Bitter orange extracts are widely used in products associated with weight loss, sports performance, and energy production. Questions have been raised about the potential of bitter orange extracts to cause drug interactions. This study examined the furanocoumarin content of four standardized bitter orange extracts (Advantra Z®) by liquid chromatography-mass spectroscopy. The results indicated that the total furanocoumarin content of each of the four extracts was less than 20 μg/g, amounts insufficient to exert significant effects on the metabolism of susceptible drugs in human subjects at the doses commonly used for these extracts.

  9. Survival analysis II: Cox regression

    NARCIS (Netherlands)

    Stel, Vianda S.; Dekker, Friedo W.; Tripepi, Giovanni; Zoccali, Carmine; Jager, Kitty J.

    2011-01-01

    In contrast to the Kaplan-Meier method, Cox proportional hazards regression can provide an effect estimate by quantifying the difference in survival between patient groups and can adjust for confounding effects of other variables. The purpose of this article is to explain the basic concepts of the

  10. Redefining the MED13L syndrome.

    Science.gov (United States)

    Adegbola, Abidemi; Musante, Luciana; Callewaert, Bert; Maciel, Patricia; Hu, Hao; Isidor, Bertrand; Picker-Minh, Sylvie; Le Caignec, Cedric; Delle Chiaie, Barbara; Vanakker, Olivier; Menten, Björn; Dheedene, Annelies; Bockaert, Nele; Roelens, Filip; Decaestecker, Karin; Silva, João; Soares, Gabriela; Lopes, Fátima; Najmabadi, Hossein; Kahrizi, Kimia; Cox, Gerald F; Angus, Steven P; Staropoli, John F; Fischer, Ute; Suckow, Vanessa; Bartsch, Oliver; Chess, Andrew; Ropers, Hans-Hilger; Wienker, Thomas F; Hübner, Christoph; Kaindl, Angela M; Kalscheuer, Vera M

    2015-10-01

    Congenital cardiac and neurodevelopmental deficits have been recently linked to the mediator complex subunit 13-like protein MED13L, a subunit of the CDK8-associated mediator complex that functions in transcriptional regulation through DNA-binding transcription factors and RNA polymerase II. Heterozygous MED13L variants cause transposition of the great arteries and intellectual disability (ID). Here, we report eight patients with predominantly novel MED13L variants who lack such complex congenital heart malformations. Rather, they depict a syndromic form of ID characterized by facial dysmorphism, ID, speech impairment, motor developmental delay with muscular hypotonia and behavioral difficulties. We thereby define a novel syndrome and significantly broaden the clinical spectrum associated with MED13L variants. A prominent feature of the MED13L neurocognitive presentation is profound language impairment, often in combination with articulatory deficits.

  11. Redefining the MED13L syndrome

    Science.gov (United States)

    Adegbola, Abidemi; Musante, Luciana; Callewaert, Bert; Maciel, Patricia; Hu, Hao; Isidor, Bertrand; Picker-Minh, Sylvie; Le Caignec, Cedric; Delle Chiaie, Barbara; Vanakker, Olivier; Menten, Björn; Dheedene, Annelies; Bockaert, Nele; Roelens, Filip; Decaestecker, Karin; Silva, João; Soares, Gabriela; Lopes, Fátima; Najmabadi, Hossein; Kahrizi, Kimia; Cox, Gerald F; Angus, Steven P; Staropoli, John F; Fischer, Ute; Suckow, Vanessa; Bartsch, Oliver; Chess, Andrew; Ropers, Hans-Hilger; Wienker, Thomas F; Hübner, Christoph; Kaindl, Angela M; Kalscheuer, Vera M

    2015-01-01

    Congenital cardiac and neurodevelopmental deficits have been recently linked to the mediator complex subunit 13-like protein MED13L, a subunit of the CDK8-associated mediator complex that functions in transcriptional regulation through DNA-binding transcription factors and RNA polymerase II. Heterozygous MED13L variants cause transposition of the great arteries and intellectual disability (ID). Here, we report eight patients with predominantly novel MED13L variants who lack such complex congenital heart malformations. Rather, they depict a syndromic form of ID characterized by facial dysmorphism, ID, speech impairment, motor developmental delay with muscular hypotonia and behavioral difficulties. We thereby define a novel syndrome and significantly broaden the clinical spectrum associated with MED13L variants. A prominent feature of the MED13L neurocognitive presentation is profound language impairment, often in combination with articulatory deficits. PMID:25758992

  12. Very bright orange fluorescent plants: endoplasmic reticulum targeting of orange fluorescent proteins as visual reporters in transgenic plants

    Directory of Open Access Journals (Sweden)

    Mann David GJ

    2012-05-01

    Full Text Available Abstract Background The expression of fluorescent protein (FP genes as real-time visual markers, both transiently and stably, has revolutionized plant biotechnology. A palette of colors of FPs is now available for use, but the diversity has generally been underutilized in plant biotechnology. Because of the green and far-red autofluorescent properties of many plant tissues and the FPs themselves, red and orange FPs (RFPs, and OFPs, respectfully appear to be the colors with maximum utility in plant biotechnology. Within the color palette OFPs have emerged as the brightest FP markers in the visible spectra. This study compares several native, near-native and modified OFPs for their “brightness” and fluorescence, therefore, their usability as marker genes in transgenic plant tissues. Results The OFPs DsRed2, tdTomato, mOrange and pporRFP were all expressed under the control of the CaMV 35S promoter in agroinfiltration-mediated transient assays in Nicotiana benthamiana. Each of these, as well as endoplasmic reticulum (ER-targeted versions, were stably expressed in transgenic Nicotiana tabacum and Arabidopsis thaliana. Congruent results were observed between transient and stable assays. Our results demonstrated that there are several adequate OFP genes available for plant transformation, including the new pporRFP, an unaltered tetramer from the hard coral Porites porites. When the tandem dimer tdTomato and the monomeric mOrange were targeted to the ER, dramatic, ca. 3-fold, increase in plant fluorescence was observed. Conclusions From our empirical data, and a search of the literature, it appears that tdTomato-ER and mOrange-ER are the two highest fluorescing FPs available as reporters for transgenic plants. The pporRFP is a brightly fluorescing tetramer, but all tetramer FPs are far less bright than the ER-targeted monomers we report here.

  13. Tang med omtanke

    DEFF Research Database (Denmark)

    Schlundt, Jørgen

    2013-01-01

    Befolkningen bør kende både mulige positive og negative effekter af fødevarer, før de spiser dem. Det mener Jørgen Schlundt, DTU Fødevareinstituttet, med henvisning til Ole G. Mouritsens kritik af instituttets udmeldinger om tang i det seneste nummer af Aktuel Naturvidenskab.......Befolkningen bør kende både mulige positive og negative effekter af fødevarer, før de spiser dem. Det mener Jørgen Schlundt, DTU Fødevareinstituttet, med henvisning til Ole G. Mouritsens kritik af instituttets udmeldinger om tang i det seneste nummer af Aktuel Naturvidenskab....

  14. Tracking the degradation of fresh orange juice and discrimination of orange varieties: an example of NMR in coordination with chemometrics analyses.

    Science.gov (United States)

    de Oliveira, Clayton R; Carneiro, Renato L; Ferreira, Antonio G

    2014-12-01

    Brazil is currently the largest exporter of concentrated orange juice and, unlike the other exporter countries, the domestic consumption is mainly based on the fresh orange juice. The quality control by evaluating the major chemical constituents under the influence of the most important factors, such as temperature and storage time of the product, is very important in this context. Therefore, the objective of this study was to evaluate the influence of temperature and time on the degradation of fresh orange juice for 24h, by using (1)H NMR technique and chemometric tools for data mining. The storage conditions at 24h led to the production of the formic, fumaric and acetic acids; and an increase of succinic and lactic acids and ethanol, which were observed at low concentration at the initial time. Furthermore, analysis by PCA has successfully distinguished the juice of different species/varieties as well as the metabolites responsible for their separation. Copyright © 2014 Elsevier Ltd. All rights reserved.

  15. TwiMed: Twitter and PubMed Comparable Corpus of Drugs, Diseases, Symptoms, and Their Relations.

    Science.gov (United States)

    Alvaro, Nestor; Miyao, Yusuke; Collier, Nigel

    2017-05-03

    Work on pharmacovigilance systems using texts from PubMed and Twitter typically target at different elements and use different annotation guidelines resulting in a scenario where there is no comparable set of documents from both Twitter and PubMed annotated in the same manner. This study aimed to provide a comparable corpus of texts from PubMed and Twitter that can be used to study drug reports from these two sources of information, allowing researchers in the area of pharmacovigilance using natural language processing (NLP) to perform experiments to better understand the similarities and differences between drug reports in Twitter and PubMed. We produced a corpus comprising 1000 tweets and 1000 PubMed sentences selected using the same strategy and annotated at entity level by the same experts (pharmacists) using the same set of guidelines. The resulting corpus, annotated by two pharmacists, comprises semantically correct annotations for a set of drugs, diseases, and symptoms. This corpus contains the annotations for 3144 entities, 2749 relations, and 5003 attributes. We present a corpus that is unique in its characteristics as this is the first corpus for pharmacovigilance curated from Twitter messages and PubMed sentences using the same data selection and annotation strategies. We believe this corpus will be of particular interest for researchers willing to compare results from pharmacovigilance systems (eg, classifiers and named entity recognition systems) when using data from Twitter and from PubMed. We hope that given the comprehensive set of drug names and the annotated entities and relations, this corpus becomes a standard resource to compare results from different pharmacovigilance studies in the area of NLP. ©Nestor Alvaro, Yusuke Miyao, Nigel Collier. Originally published in JMIR Public Health and Surveillance (http://publichealth.jmir.org), 03.05.2017.

  16. A review of Agent Orange and its associated oncologic risk of genitourinary cancers.

    Science.gov (United States)

    Chang, Chrystal; Benson, Michael; Fam, Mina M

    2017-11-01

    Agent Orange is an herbicide sprayed widely in Vietnam that is linked to a variety of malignancies in as early as 1991.Since then, there has been concern for, and subsequent interest in studying, the potential connection between Agent Orange and other malignancies. In the past 2 decades, there have been significant changes in the opinion of the National Academy of Science regarding Agent Orange and certain genitourinary malignancies. Herein, we review the literature regarding the potential link between Agent Orange and various urological cancers, including prostate, bladder, testicular, and renal cancers. Copyright © 2017 Elsevier Inc. All rights reserved.

  17. DRIS norms for 'Valencia' sweet orange on three rootstocks

    OpenAIRE

    Mourão Filho,Francisco de Assis Alves; Azevedo,João Carlos

    2003-01-01

    Diagnosis and Recommendation Integrated System (DRIS) applies nutrient ratios instead of the isolated concentration values of each nutrient in interpretation of tissue analysis. The objectives of this research were to establish adequate DRIS norms for 'Valencia' sweet orange irrigated commercial groves budded on three rootstocks and correlate indexes of nutrition balance with yield. Experiments were conducted in São Paulo State, Brazil. Rootstocks Rangpur lime, Caipira sweet orange, and Ponci...

  18. Structural and luminescence properties of Sm3+ -doped bismuth phosphate glass for orange-red photonic applications.

    Science.gov (United States)

    Damodaraiah, S; Reddy Prasad, V; Ratnakaram, Y C

    2018-05-01

    In the present study, the effect of bismuth oxide (Bi 2 O 3 ) content on the structural and optical properties of 0.5Sm 3+ -doped phosphate glass and the effect of concentration on structural and optical properties of Sm 3+ -doped bismuth phosphate (BiP) glass were studied. Structural characterization was accomplished using X-ray diffraction (XRD), scanning electron microscopy (SEM) with energy dispersive spectroscopy (EDS), Fourier transform infrared (FTIR) spectroscopy and 31 P nuclear magnetic resonance (NMR) spectroscopy. Optical properties were studied using absorption, photoluminescence and decay measurements. Using optical absorption spectra, Judd-Ofelt parameters were derived to determine the local structure and bonding in the vicinity of Sm 3+ ions. The emission spectra of Sm 3+ -doped BiP glass showed two intense emission bands, 4 G 5/2 → 6 H 7/2 (orange) and 4 G 5/2 → 6 H 9/2 (red) for which the stimulated emission cross-sections (σ e ) and branching ratios (β) were found to be higher. The quantum efficiencies were also calculated from decay measurements recorded for the 4 G 5/2 level of Sm 3+ ions. The suitable combination of Bi 2 O 3 (10 mol%) and Sm 3+ (0.5 mol%) ions in these glasses acted as an efficient lasing material and might be suitable for the development of visible orange-red photonic materials. Copyright © 2018 John Wiley & Sons, Ltd.

  19. Interleukin-4 and specific IgE to oranges levels study in persons with allergic anamnesis

    Directory of Open Access Journals (Sweden)

    A. S. Prilutskiy

    2014-04-01

    Full Text Available Introduction. Currently allergic diseases pose a global health concern. The connection between immunoglobulin E antibodies (IgE-Ab and allergic disorders is well established. However, the mechanisms through which IgE-Ab contribute to the pathogenesis of allergic diseases are yet to be elucidated. There are reports that highlight the crucial role of interleukins in the regulation of these processes. Thus, some authors pay attention to interleukin-4 (IL-4 which is important for the control of all aspects of the humoral response. Recent epidemiological studies show that oranges are largely consumed worldwide and commonly included in the diet in many countries being one of the main reasons of food allergy. So it was decided to investigate possible links between the levels of IL-4 and IgE-Ab both total and specific to the orange allergens. The aim of this study is to determine the levels of IL-4, total and specific orange IgE-Ab (sIgE-Ab concentrations in individuals with a history of allergic diseases and find some statistically significant links between these parameters. Materials and methods. We selected and investigated serums of 180 patients between 7 months and 78 years with a history of allergic diseases who complained on frequent development of various allergic reactions, mainly atopic dermatitis, urticaria, etc. Determination of the levels of IL-4, total and specific IgE-Ab to the orange allergens was carried out using the first national ELISA test systems of the fourth generation (“Ukrmed-Don”, Donetsk, Ukraine. Specific IgE and IL-4 levels were examined in 180 patients and total IgE levels were investigated in 161 patients. Statistical analysis was performed using the licensed program “MedStat” (Donetsk, Ukraine. The median, the median error, the left and right limits of 95% confidence interval were calculated for all of three samples (IL-4, total IgE-Ab, sIgE-Ab. Central tendencies of two subgroups of IL-4, which were

  20. Metabolic engineering of β-carotene in orange fruit increases its in vivo antioxidant properties.

    Science.gov (United States)

    Pons, Elsa; Alquézar, Berta; Rodríguez, Ana; Martorell, Patricia; Genovés, Salvador; Ramón, Daniel; Rodrigo, María Jesús; Zacarías, Lorenzo; Peña, Leandro

    2014-01-01

    Orange is a major crop and an important source of health-promoting bioactive compounds. Increasing the levels of specific antioxidants in orange fruit through metabolic engineering could strengthen the fruit's health benefits. In this work, we have afforded enhancing the β-carotene content of orange fruit through blocking by RNA interference the expression of an endogenous β-carotene hydroxylase gene (Csβ-CHX) that is involved in the conversion of β-carotene into xanthophylls. Additionally, we have simultaneously overexpressed a key regulator gene of flowering transition, the FLOWERING LOCUS T from sweet orange (CsFT), in the transgenic juvenile plants, which allowed us to obtain fruit in an extremely short period of time. Silencing the Csβ-CHX gene resulted in oranges with a deep yellow ('golden') phenotype and significant increases (up to 36-fold) in β-carotene content in the pulp. The capacity of β-carotene-enriched oranges for protection against oxidative stress in vivo was assessed using Caenorhabditis elegans as experimental animal model. Golden oranges induced a 20% higher antioxidant effect than the isogenic control. This is the first example of the successful metabolic engineering of the β-carotene content (or the content of any other phytonutrient) in oranges and demonstrates the potential of genetic engineering for the nutritional enhancement of fruit tree crops. © 2013 Society for Experimental Biology, Association of Applied Biologists and John Wiley & Sons Ltd.

  1. Quality of jinchen orange juice treated with irradiation and pasteurization

    International Nuclear Information System (INIS)

    Qiao Yu; Cheng Wei; Wang Shaohua; Xiong Guangquan; Liao Li; Chen Xueling; Fan Gang; Pan Siyi

    2010-01-01

    Jinchen orange juice was treated by pasteurization and irradiation (1.4, 2.8 and 5.6 kGy) to study the effects of sterilization methods on quality of orange juice. The volatile compounds were analyzed by solid phase micro-extraction method combined with GC-MS. The juice color, pH and Vc content were determined, and sensory evaluation of the juice were evaluated. The results showed a total of 54, 47, 57, 55, 53 kinds of compounds were detected in fresh juice, pasteurized juice and 3 irradiated juices, respectively. The irradiated juices had bigger peak area of volatile compounds than pasteurized juice,and the biggest peak area was found in 2.8 kGy irradiation sample. β - myrcene, D - limonene and γ-terpinene, which were the characteristic aroma compounds in orange juice, were detected a higher level in irradiation sample than pasteurization. Vc content and aroma decreased after all treatments. The sample after 1.4 kGy treatment showed highest score in sensory evaluation. It was concluded that low dose irradiation could be used in sterilization processing of orange juice. (authors)

  2. MCEM algorithm for the log-Gaussian Cox process

    OpenAIRE

    Delmas, Celine; Dubois-Peyrard, Nathalie; Sabbadin, Regis

    2014-01-01

    Log-Gaussian Cox processes are an important class of models for aggregated point patterns. They have been largely used in spatial epidemiology (Diggle et al., 2005), in agronomy (Bourgeois et al., 2012), in forestry (Moller et al.), in ecology (sightings of wild animals) or in environmental sciences (radioactivity counts). A log-Gaussian Cox process is a Poisson process with a stochastic intensity depending on a Gaussian random eld. We consider the case where this Gaussian random eld is ...

  3. Hepatic ischemia and reperfusion injury in the absence of myeloid cell-derived COX-2 in mice.

    Directory of Open Access Journals (Sweden)

    Sergio Duarte

    Full Text Available Cyclooxygenase-2 (COX-2 is a mediator of hepatic ischemia and reperfusion injury (IRI. While both global COX-2 deletion and pharmacologic COX-2 inhibition ameliorate liver IRI, the clinical use of COX-2 inhibitors has been linked to increased risks of heart attack and stroke. Therefore, a better understanding of the role of COX-2 in different cell types may lead to improved therapeutic strategies for hepatic IRI. Macrophages of myeloid origin are currently considered to be important sources of the COX-2 in damaged livers. Here, we used a Cox-2flox conditional knockout mouse (COX-2-M/-M to examine the function of COX-2 expression in myeloid cells during liver IRI. COX-2-M/-M mice and their WT control littermates were subjected to partial liver ischemia followed by reperfusion. COX-2-M/-M macrophages did not express COX-2 upon lipopolysaccharide stimulation and COX-2-M/-M livers showed reduced levels of COX-2 protein post-IRI. Nevertheless, selective deletion of myeloid cell-derived COX-2 failed to ameliorate liver IRI; serum transaminases and histology were comparable in both COX-2-M/-M and WT mice. COX-2-M/-M livers, like WT livers, developed extensive necrosis, vascular congestion, leukocyte infiltration and matrix metalloproteinase-9 (MMP-9 expression post-reperfusion. In addition, myeloid COX-2 deletion led to a transient increase in IL-6 levels after hepatic reperfusion, when compared to controls. Administration of celecoxib, a selective COX-2 inhibitor, resulted in significantly improved liver function and histology in both COX-2-M/-M and WT mice post-reperfusion, providing evidence that COX-2-mediated liver IRI is caused by COX-2 derived from a source(s other than myeloid cells. In conclusion, these results support the view that myeloid COX-2, including myeloid-macrophage COX-2, is not responsible for the hepatic IRI phenotype.

  4. PubMed Informer: Monitoring MEDLINE/PubMed through E-mail Alerts, SMS, PDA downloads and RSS feeds

    Science.gov (United States)

    Muin, Michael; Fontelo, Paul; Ackerman, Michael

    2005-01-01

    Summary PubMed Informer is a Web-based monitoring tool for topics of interest from MEDLINE/PubMed primarily designed for healthcare professionals. Five tracking methods are available: Web access, e-mail, Short Message Service (SMS), PDA downloads and RSS feeds. PubMed Informer delivers focused search updates and specific information to users with varying information-seeking practices. PMID:16779344

  5. Metro orange line BRT project evaluation.

    Science.gov (United States)

    2011-10-01

    In partnership with the Los Angeles County Metropolitan Transportation Authority (Metro) and the Federal Transit Administration (FTA), the National Bus Rapid Transit Institute (NBRTI) conducted an evaluation of the Metro Orange Line BRT service, whic...

  6. Identifikasi Jumlah dan Tingkat Aktivitas Orang Berbasis Pengolahan Citra Menggunakan Raspberry Pi

    Directory of Open Access Journals (Sweden)

    Daniel Krisrenanto

    2017-03-01

    Full Text Available Air conditioner (AC merupakan suatu perangkat yang paling banyak digunakan sebagai pendingin ruangan. Walaupun AC saat ini sudah menggunakan teknologi hemat energi, namun apabila tidak digunakan dengan baik maka penggunaan AC hanya menjadi suatu pemborosan listrik saja. Untuk mengurangi pemborosan listrik pada AC, maka pengaturan suhu harus disesuaikan dengan kondisi ruangan. Beberapa faktor yang mempengaruhi kondisi ruangan antara lain adalah jumlah orang serta tingkat aktivitas dalam ruangan. Sebagai upaya penghematan konsumsi listrik pada AC, maka dalam penelitian ini dilakukan rancang bangun suatu sistem identifikasi jumlah orang dan tingkat aktivitas. Pada sistem ini digunakan kamera USB sebagai perangkat pengambil citra. Pada pengolahan citra menggunakan metode Histogram of Oriented Gradient (HOG sebagai penghitung jumlah orang, sedangkan metode background subtraction digunakan sebagai penghitung tingkat aktivitas. Sistem ini diimplementasikan ke dalam Raspberry Pi 3 sebagai mikrokontroler. Hasil pengujian menunjukkan bahwa sistem dapat mendeteksi orang dari jarak 3 m sampai 9 m dan membedakan 2 orang dengan jarak antara 30 cm sampai 150 cm. Sistem juga dapat membedakan tingkat aktivitas sedikit, sedang dan tinggi.

  7. Inhibition of 5-LOX, COX-1, and COX-2 increases tendon healing and reduces muscle fibrosis and lipid accumulation after rotator cuff repair.

    Science.gov (United States)

    Oak, Nikhil R; Gumucio, Jonathan P; Flood, Michael D; Saripalli, Anjali L; Davis, Max E; Harning, Julie A; Lynch, Evan B; Roche, Stuart M; Bedi, Asheesh; Mendias, Christopher L

    2014-12-01

    The repair and restoration of function after chronic rotator cuff tears are often complicated by muscle atrophy, fibrosis, and fatty degeneration of the diseased muscle. The inflammatory response has been implicated in the development of fatty degeneration after cuff injuries. Licofelone is a novel anti-inflammatory drug that inhibits 5-lipoxygenase (5-LOX), as well as cyclooxygenase (COX)-1 and COX-2 enzymes, which play important roles in inducing inflammation after injuries. While previous studies have demonstrated that nonsteroidal anti-inflammatory drugs and selective inhibitors of COX-2 (coxibs) may prevent the proper healing of muscles and tendons, studies about bone and cartilage have demonstrated that drugs that inhibit 5-LOX concurrently with COX-1 and COX-2 may enhance tissue regeneration. After the repair of a chronic rotator cuff tear in rats, licofelone would increase the load to failure of repaired tendons and increase the force production of muscle fibers. Controlled laboratory study. Rats underwent supraspinatus release followed by repair 28 days later. After repair, rats began a treatment regimen of either licofelone or a vehicle for 14 days, at which time animals were euthanized. Supraspinatus muscles and tendons were then subjected to contractile, mechanical, histological, and biochemical analyses. Compared with controls, licofelone-treated rats had a grossly apparent decrease in inflammation and increased fibrocartilage formation at the enthesis, along with a 62% increase in the maximum load to failure and a 51% increase in peak stress to failure. Licofelone resulted in a marked reduction in fibrosis and lipid content in supraspinatus muscles as well as reduced expression of several genes involved in fatty infiltration. Despite the decline in fibrosis and fat accumulation, muscle fiber specific force production was reduced by 23%. The postoperative treatment of cuff repair with licofelone may reduce fatty degeneration and enhance the development

  8. Significance of Cox-2 expression in rectal cancers with or without preoperative radiotherapy

    International Nuclear Information System (INIS)

    Pachkoria, Ketevan; Zhang Hong; Adell, Gunnar; Jarlsfelt, Ingvar; Sun Xiaofeng

    2005-01-01

    Purpose: Radiotherapy has reduced local recurrence of rectal cancers, but the result is not satisfactory. Further biologic factors are needed to identify patients for more effective radiotherapy. Our aims were to investigate the relationship of cyclooxygenase-2 (Cox-2) expression to radiotherapy, and clinicopathologic/biologic variables in rectal cancers with or without radiotherapy. Methods and Materials: Cox-2 expression was immunohistochemically examined in distal normal mucosa (n = 28), in adjacent normal mucosa (n = 107), in primary cancer (n = 138), lymph node metastasis (n = 30), and biopsy (n = 85). The patients participated in a rectal cancer trial of preoperative radiotherapy. Results: Cox-2 expression was increased in primary tumor compared with normal mucosa (p < 0.0001), but there was no significant change between primary tumor and metastasis. Cox-2 positivity was or tended to be related to more p53 and Ki-67 expression, and less apoptosis (p ≤ 0.05). In Cox-2-negative cases of either biopsy (p = 0.01) or surgical samples (p = 0.02), radiotherapy was related to less frequency of local recurrence, but this was not the case in Cox-2-positive cases. Conclusion: Cox-2 expression seemed to be an early event involved in rectal cancer development. Radiotherapy might reduce a rate of local recurrence in the patients with Cox-2 weakly stained tumors, but not in those with Cox-2 strongly stained tumors

  9. Kinetic of orange pigment production from Monascus ruber on submerged fermentation.

    Science.gov (United States)

    Vendruscolo, Francielo; Schmidell, Willibaldo; de Oliveira, Débora; Ninow, Jorge Luiz

    2017-01-01

    Pigments produced by species of Monascus have been used to coloring rice, meat, sauces, wines and beers in East Asian countries. Monascus can produce orange (precursor), yellow and red pigments. Orange pigments have low solubility in culture media and when react with amino groups they become red and largely soluble. The orange pigments are an alternative to industrial pigment production because the low solubility facilitates the downstream operations. The aim of this work was to study the kinetic on the production of orange pigments by Monascus ruber CCT 3802. The shaking frequency of 300 rpm was favorable to production, whereas higher shaking frequencies showed negative effect. Pigment production was partially associated with cell growth, the critical dissolved oxygen concentration was between 0.894 and 1.388 mgO 2  L -1 at 30 °C, and limiting conditions of dissolved oxygen decreased the production of orange pigments. The maintenance coefficient (mo) and the conversion factor of oxygen in biomass (Yo) were 18.603 mgO 2  g x -1  h -1 and 3.133 g x  gO 2 -1 and the consideration of these parameters in the oxygen balance to estimate the biomass concentration provided good fits to the experimental data.

  10. Multi-omics facilitated variable selection in Cox-regression model for cancer prognosis prediction.

    Science.gov (United States)

    Liu, Cong; Wang, Xujun; Genchev, Georgi Z; Lu, Hui

    2017-07-15

    New developments in high-throughput genomic technologies have enabled the measurement of diverse types of omics biomarkers in a cost-efficient and clinically-feasible manner. Developing computational methods and tools for analysis and translation of such genomic data into clinically-relevant information is an ongoing and active area of investigation. For example, several studies have utilized an unsupervised learning framework to cluster patients by integrating omics data. Despite such recent advances, predicting cancer prognosis using integrated omics biomarkers remains a challenge. There is also a shortage of computational tools for predicting cancer prognosis by using supervised learning methods. The current standard approach is to fit a Cox regression model by concatenating the different types of omics data in a linear manner, while penalty could be added for feature selection. A more powerful approach, however, would be to incorporate data by considering relationships among omics datatypes. Here we developed two methods: a SKI-Cox method and a wLASSO-Cox method to incorporate the association among different types of omics data. Both methods fit the Cox proportional hazards model and predict a risk score based on mRNA expression profiles. SKI-Cox borrows the information generated by these additional types of omics data to guide variable selection, while wLASSO-Cox incorporates this information as a penalty factor during model fitting. We show that SKI-Cox and wLASSO-Cox models select more true variables than a LASSO-Cox model in simulation studies. We assess the performance of SKI-Cox and wLASSO-Cox using TCGA glioblastoma multiforme and lung adenocarcinoma data. In each case, mRNA expression, methylation, and copy number variation data are integrated to predict the overall survival time of cancer patients. Our methods achieve better performance in predicting patients' survival in glioblastoma and lung adenocarcinoma. Copyright © 2017. Published by Elsevier

  11. Population death sequences and Cox processes driven by interacting Feller diffusions

    CERN Document Server

    Wei Gang; Feng Jian Feng

    2002-01-01

    We carry out a complete study on the relationship between Cox processes driven by interacting Feller diffusions and death sequences of immigration-emigration linked population networks. It is first proved that the Cox process driven by a Feller diffusion is equivalent to the death sequence of a birth and death process. The conclusion is then generalized to the case of Cox processes driven by interacting Feller diffusions and death sequences of interacting populations.

  12. Population death sequences and Cox processes driven by interacting Feller diffusions

    International Nuclear Information System (INIS)

    Wei Gang; Clifford, Peter; Feng Jianfeng

    2002-01-01

    We carry out a complete study on the relationship between Cox processes driven by interacting Feller diffusions and death sequences of immigration-emigration linked population networks. It is first proved that the Cox process driven by a Feller diffusion is equivalent to the death sequence of a birth and death process. The conclusion is then generalized to the case of Cox processes driven by interacting Feller diffusions and death sequences of interacting populations

  13. Population death sequences and Cox processes driven by interacting Feller diffusions

    Energy Technology Data Exchange (ETDEWEB)

    Wei Gang [Department of Mathematics, Baptist University, Hong Kong (China); Clifford, Peter [Department of Statistics, 1 South Parks Road, Oxford (United Kingdom); Feng Jianfeng [COGS, Sussex University, Brighton (United Kingdom)

    2002-11-08

    We carry out a complete study on the relationship between Cox processes driven by interacting Feller diffusions and death sequences of immigration-emigration linked population networks. It is first proved that the Cox process driven by a Feller diffusion is equivalent to the death sequence of a birth and death process. The conclusion is then generalized to the case of Cox processes driven by interacting Feller diffusions and death sequences of interacting populations.

  14. A marvel of precision: MedAustron

    CERN Document Server

    Anaïs Schaeffer

    2013-01-01

    MedAustron, which is currently being built in Austria, will be one of the most advanced centres for ion beam therapy and research in Europe. It is based on the same design as the Italian National Centre for Oncological Hadrontherapy (CNAO), which in turn is based on the CERN-led Proton Ion Medical Machine Study (PIMMS). MedAustron should welcome its first patient at the end of 2015.   Layout of the MedAustron accelerator complex.  With three ion-sources, a linac, a synchrotron and four irradiation rooms (see picture), MedAustron is a huge accelerator complex. Among other equipment, it comprises 300 magnets of 30 different types, all designed at CERN but produced at different sites: “We are working with five main suppliers from Europe and Russia,” explains Thomas Zickler, leader of the MedAustron magnet group. “All the magnets come to CERN to undergo a series of strict acceptance tests.” From the interfaces, to the electrical insulation, the co...

  15. Fracto- mechanoluminescence and thermoluminescence properties of orange-red emitting Eu{sup 3+} doped Ca{sub 2}Al{sub 2}SiO{sub 7} phosphors

    Energy Technology Data Exchange (ETDEWEB)

    Tiwari, Geetanjali, E-mail: geetanjali.tiwari10@gmail.com [School of Studies in Physics and Astrophysics, Pt. Ravishankar Shukla University, Raipur, C.G., 492010 (India); Brahme, Nameeta, E-mail: namitabrahme@gmail.com [School of Studies in Physics and Astrophysics, Pt. Ravishankar Shukla University, Raipur, C.G., 492010 (India); Sharma, Ravi [Department of Physics, Govt. Arts and Commerce Girls College, Devendra Nagar, Raipur, C.G. (India); Bisen, D.P.; Sao, Sanjay K. [School of Studies in Physics and Astrophysics, Pt. Ravishankar Shukla University, Raipur, C.G., 492010 (India); Khare, Ayush [Department of Physics, National Institute of Technology, Raipur - 492 010 (India)

    2017-03-15

    The suitability of nano-structured Ca{sub 2}Al{sub 2}SiO{sub 7}:Eu{sup 3+} phosphors for thermoluminescence and mechanoluminescence dosimeter were investigated. Europium doped di-calcium di-aluminum silicate phosphor was synthesised by the combustion assisted method and annealed at 1100 °C for 4 h in reducing and oxidizing environments. The prepared Ca{sub 2}Al{sub 2}SiO{sub 7}:Eu{sup 3+} phosphor was characterized by X-ray diffractometer (XRD), transmission electron microscopy (TEM), scanning electron microscopy (SEM) with energy dispersive x-ray spectroscopy (EDX), photoluminescence (PL) and decay characteristics. The phase structure of sintered phosphor has akermanite type which belongs to the tetragonal crystallography; this structure is a member of the melilite group and forms a layered compound. The chemical composition of the sintered Ca{sub 2}Al{sub 2}SiO{sub 7}:Eu{sup 3+} phosphor was confirmed by EDX spectra. Mechanoluminescence (ML) and thermoluminescence (TL) studies revealed that the ML and TL intensity increases with activator concentration. Optimum ML was observed for the sample having 2 mol% of Eu ions. The TL intensity of Ca{sub 2}Al{sub 2}SiO{sub 7}:Eu{sup 3+} was recorded for different exposure times of γ -irradiation and it was observed that TL intensity is maximum for γ dose of 1770 Gy. The PL spectra indicated that Ca{sub 2}Al{sub 2}SiO{sub 7}:Eu{sup 3+} could be excited effectively by near ultraviolet (NUV) light and exhibited bright orange-red emission with excellent colour stability. CIE colour coordinates of the prepared Ca{sub 2}Al{sub 2}SiO{sub 7}:Eu{sup 3+} phosphor was found suitable as orange-red light emitting phosphor with a CIE value of (x=0.6142, y=0.3849) and correlated colour temperature (CCT) is 1250 K. Therefore, it is considered to be a new promising orange-red emitting phosphor for white light emitting diode (LED) application.

  16. Adsorption study on orange peel: Removal of Ni(II) ions from ...

    African Journals Online (AJOL)

    orange peel was investigated to evaluate the effects of pH, initial nickel ion concentration and adsorbent dose on the removal of Ni(II) systematically. The optimal pH value for Ni(II) adsorption onto the orange peel was found to be 5.0. Greater ...

  17. Effect of orange rust on sugarcane breeding program at canal Point

    Science.gov (United States)

    Orange rust of sugarcane (Saccharum spp. hybrids), caused by Puccinia kuehnii (W. Krüger) E.J. Butler, appeared in the Western Hemisphere ten years ago. Orange rust substantially reduces yields in susceptible sugarcane genotypes. Majority of the commercial cultivars were susceptible at the time of o...

  18. Forecasts of non-Gaussian parameter spaces using Box-Cox transformations

    Science.gov (United States)

    Joachimi, B.; Taylor, A. N.

    2011-09-01

    Forecasts of statistical constraints on model parameters using the Fisher matrix abound in many fields of astrophysics. The Fisher matrix formalism involves the assumption of Gaussianity in parameter space and hence fails to predict complex features of posterior probability distributions. Combining the standard Fisher matrix with Box-Cox transformations, we propose a novel method that accurately predicts arbitrary posterior shapes. The Box-Cox transformations are applied to parameter space to render it approximately multivariate Gaussian, performing the Fisher matrix calculation on the transformed parameters. We demonstrate that, after the Box-Cox parameters have been determined from an initial likelihood evaluation, the method correctly predicts changes in the posterior when varying various parameters of the experimental setup and the data analysis, with marginally higher computational cost than a standard Fisher matrix calculation. We apply the Box-Cox-Fisher formalism to forecast cosmological parameter constraints by future weak gravitational lensing surveys. The characteristic non-linear degeneracy between matter density parameter and normalization of matter density fluctuations is reproduced for several cases, and the capabilities of breaking this degeneracy by weak-lensing three-point statistics is investigated. Possible applications of Box-Cox transformations of posterior distributions are discussed, including the prospects for performing statistical data analysis steps in the transformed Gaussianized parameter space.

  19. The Arabidopsis mediator complex subunits MED16, MED14, and MED2 regulate mediator and RNA polymerase II recruitment to CBF-responsive cold-regulated genes.

    Science.gov (United States)

    Hemsley, Piers A; Hurst, Charlotte H; Kaliyadasa, Ewon; Lamb, Rebecca; Knight, Marc R; De Cothi, Elizabeth A; Steele, John F; Knight, Heather

    2014-01-01

    The Mediator16 (MED16; formerly termed SENSITIVE TO FREEZING6 [SFR6]) subunit of the plant Mediator transcriptional coactivator complex regulates cold-responsive gene expression in Arabidopsis thaliana, acting downstream of the C-repeat binding factor (CBF) transcription factors to recruit the core Mediator complex to cold-regulated genes. Here, we use loss-of-function mutants to show that RNA polymerase II recruitment to CBF-responsive cold-regulated genes requires MED16, MED2, and MED14 subunits. Transcription of genes known to be regulated via CBFs binding to the C-repeat motif/drought-responsive element promoter motif requires all three Mediator subunits, as does cold acclimation-induced freezing tolerance. In addition, these three subunits are required for low temperature-induced expression of some other, but not all, cold-responsive genes, including genes that are not known targets of CBFs. Genes inducible by darkness also required MED16 but required a different combination of Mediator subunits for their expression than the genes induced by cold. Together, our data illustrate that plants control transcription of specific genes through the action of subsets of Mediator subunits; the specific combination defined by the nature of the stimulus but also by the identity of the gene induced.

  20. Metabolomic comparative analysis of the phloem sap of curry leaf tree (Bergera koenegii), orange jasmine (Murraya paniculata), and Valencia sweet orange (Citrus sinensis) supports their differential responses to Huanglongbing

    OpenAIRE

    Killiny, Nabil

    2016-01-01

    Orange jasmine, Murraya paniculata and curry leaf tree, Bergera koenegii are alternative hosts for Diaphorina citri, the vector of Candidatus Liberibacter asiaticus (CLas), the pathogen of huanglongbing (HLB) in citrus. D. citri feeds on the phloem sap where CLas grows. It has been shown that orange jasmine was a better host than curry leaf tree to D. citri. In addition, CLas can infect orange jasmine but not curry leaf tree. Here, we compared the phloem sap composition of these 2 plants to t...

  1. Improving Your Data Transformations: Applying the Box-Cox Transformation

    Directory of Open Access Journals (Sweden)

    Jason W. Osborne

    2010-10-01

    Full Text Available Many of us in the social sciences deal with data that do not conform to assumptions of normality and/or homoscedasticity/homogeneity of variance. Some research has shown that parametric tests (e.g., multiple regression, ANOVA can be robust to modest violations of these assumptions. Yet the reality is that almost all analyses (even nonparametric tests benefit from improved the normality of variables, particularly where substantial non-normality is present. While many are familiar with select traditional transformations (e.g., square root, log, inverse for improving normality, the Box-Cox transformation (Box & Cox, 1964 represents a family of power transformations that incorporates and extends the traditional options to help researchers easily find the optimal normalizing transformation for each variable. As such, Box-Cox represents a potential best practice where normalizing data or equalizing variance is desired. This paper briefly presents an overview of traditional normalizing transformations and how Box-Cox incorporates, extends, and improves on these traditional approaches to normalizing data. Examples of applications are presented, and details of how to automate and use this technique in SPSS and SAS are included.

  2. MATHEMATICAL MODELING OF ORANGE SEED DRYING KINETICS

    Directory of Open Access Journals (Sweden)

    Daniele Penteado Rosa

    2015-06-01

    Full Text Available Drying of orange seeds representing waste products from juice processing was studied in the temperatures of 40, 50, 60 and 70 °C and drying velocities of 0.6, 1.0 and 1.4 m/s. Experimental drying kinetics of orange seeds were obtained using a convective air forced dryer. Three thin-layer models: Page model, Lewis model, and the Henderson-Pabis model and the diffusive model were used to predict the drying curves. The Henderson-Pabis and the diffusive models show the best fitting performance and statistical evaluations. Moreover, the temperature dependence on the effective diffusivity followed an Arrhenius relationship, and the activation energies ranging from 16.174 to 16.842 kJ/mol

  3. Mødet med det Andet

    DEFF Research Database (Denmark)

    Marchwinski, Alena

    2002-01-01

    Da Christen Købke i 1830 malte sitt bilde fra Kunstakademiets avstøpningssamling på Charlottenborg, skildret han en situasjon som vordende danske kunstnere hadde vært fortrolige med i flere generasjoner: en ung mann betrakter en avstøpning av en antikk skulptur. Med utgangspunkt i kombinasjonen a...

  4. Et felteksperiment med Kærlighed i Kaos

    DEFF Research Database (Denmark)

    Christensen, Christiane Præstgaard; Scavenius Sonne-Schmidt, Christoffer

    Som et nyt tilbud til danske forældre med børn med ADHD og ADHD-lignende vanskeligheder har ADHDforeningen udviklet forældretræningsprogrammet Kærlighed i Kaos, hvor frivillige hjælper forældre til børn med ADHD, der står med et særligt vanskeligt opdragelsesarbejde. Denne rapport har til formål......, når forældrene stiller krav til børnene. Resultaterne i denne rapport har interesse for fagpersoner, behandlere, undervisere, beslutningstagere, frivillige organisationer, foreninger og de mange nuværende og kommende familier, som dagligt kæmper med adfærdsvanskeligheder – såsom ADHD. Effektmålingen...

  5. Redefining the MED13L syndrome

    OpenAIRE

    Adegbola, Abidemi; Musante, Luciana; Callewaert, Bert; Maciel, Patricia; Hu, Hao; Isidor, Bertrand; Picker-Minh, Sylvie; Le Caignec, Cedric; Delle Chiaie, Barbara; Vanakker, Olivier; Menten, Björn; Dheedene, Annelies; Bockaert, Nele; Roelens, Filip; Decaestecker, Karin

    2015-01-01

    Congenital cardiac and neurodevelopmental deficits have been recently linked to the mediator complex subunit 13-like protein MED13L, a subunit of the CDK8-associated mediator complex that functions in transcriptional regulation through DNA-binding transcription factors and RNA polymerase II. Heterozygous MED13L variants cause transposition of the great arteries and intellectual disability (ID). Here, we report eight patients with predominantly novel MED13L variants who lack such complex conge...

  6. Impact of U.S. duty drawback on the demand for orange juice

    OpenAIRE

    Brown, Mark G.; Fernandes, Waldir B.; Spreen, Thomas H.; Lee, Jonq-Ying

    2003-01-01

    A demand system model differentiating goods by origin is developed to examine impacts of duty drawback on U.S. orange juice exports and prices. An empirical analysis suggests that on average duty drawback has increased annual orange juice exports by about 16.5 million SSE gallons or 11% of export sales, and has supported the U.S. price of orange juice by about 2 cents per gallon. Not all benefits of duty drawback go to exporters. Importers who own drawback credits but do not export product ma...

  7. Subspecies identification of captive Orang Utan in Melaka based on D-loop mitochondria DNA

    Science.gov (United States)

    Kamaluddin, Siti Norsyuhada; Yaakop, Salmah; Idris, Wan Mohd Razi; Rovie-Ryan, Jeffrine Japning; Md-Zain, Badrul Munir

    2018-04-01

    Mitochondrial DNA of Bornean Orang Utan populations suggests that there are three different subspecies (Pongo pygmaeus pygmaeus; Sarawak & Northwest Kalimantan, P. p. wurmbii; Southern West Kalimantan and Central Kalimantan, P. p. morio; East Kalimantan and Sabah). The subspecies of Orang Utans in captivity are difficult to determine through morphological observation. Thus, misidentification by ranger or zoo staffs leads to unwanted consequences especially towards conservation efforts of Orang Utan. The main objective of this study was to identify the subspecies and the geographic origin of 10 Orang Utans in Zoo Melaka and A' Famosa by using partial mitochondrial D-loop gene sequences. DNA of all individuals was extracted from FTA Card. Data analyses were performed using Maximum Parsimony, MP and Neighbor Joining, NJ. Molecular phylogeny analysis revealed that all the samples likely belong to one species of Sumatran Orang Utan (P. abelii) and three different subspecies of Bornean Orang Utans (P. p. pygmaeus, P. p. morio, and P. p. wurmbii). The results obtained in this study indirectly help the management of zoos in term of conservation and visitor's education.

  8. Interception and retention of 238Pu deposition by orange trees

    International Nuclear Information System (INIS)

    Pinder, J.E. III; Adriano, D.C.; Ciravolo, T.G.; Doswell, A.C.; Yehling, D.M.

    1987-01-01

    Radioisotope thermoelectric generators (RTG) transform the heat produced during the alpha decay of 238 Pu into electrical energy for use by deep-space probes, such as the Voyager spacecraft, which have returned images and other data from Jupiter, Saturn and Uranus. Future missions involving RTGs may be launched aboard the space shuttle, and there is a remote possibility that an explosion of liquid-hydrogen and liquid-oxygen fuel could rupture the RTGs and disperse 238 Pu into the atmosphere over central Florida. Research was performed to determine the potential transport to man of atmospherically dispersed Pu via contaminated orange fruits. The results indicate that the major contamination of oranges would result from the interception and retention of 238 Pu deposition by fruits. The resulting surface contamination could enter human food chains through transfer to internal tissues during peeling or in the reconstituted juices and flavorings made from orange skins. The interception of 238 Pu deposition by fruits is especially important because the results indicate no measurable loss of Pu from fruit surfaces through time or with washing. Approximately 1% of the 238 Pu deposited onto an orange grove would be harvested in the year following deposition

  9. Med det sociale som designmateriale

    DEFF Research Database (Denmark)

    Brandt, Eva; Binder, Thomas

    2016-01-01

    Samarbejde, samskabelse og social nysgerrighed er i dag en præmis for den nyskabende designer. Det sociale er det nye designmateriale som unge designere giver sig i kast med når f.eks. Emmy Linde samarbejder med plejehjemsbeboere, deres pårørende, plejepersonale og fysioterapeuter for at designe ...

  10. Ukraine's Orange Revolution and U.S. Policy

    National Research Council Canada - National Science Library

    Woehrel, Steven

    2005-01-01

    In January 2005, Viktor Yushchenko became Ukraine's new President, after massive demonstrations helped to overturn the former regime's electoral fraud, in what has been dubbed the "Orange Revolution...

  11. Acidification of apple and orange hosts by Penicillium digitatum and Penicillium expansum.

    Science.gov (United States)

    Vilanova, L; Viñas, I; Torres, R; Usall, J; Buron-Moles, G; Teixidó, N

    2014-05-16

    New information about virulence mechanisms of Penicillium digitatum and Penicillium expansum could be an important avenue to control fungal diseases. In this study, the ability of P. digitatum and P. expansum to enhance their virulence by locally modulating the pH of oranges and apples was evaluated. For each host, pH changes with a compatible pathogen and a non-host pathogen were recorded, and the levels of different organic acids were evaluated to establish possible relationships with host pH modifications. Moreover, fruits were harvested at three maturity stages to determine whether fruit maturity could affect the pathogens' virulence. The pH of oranges and apples decreased when the compatible pathogens (P. digitatum and P. expansum, respectively) decayed the fruit. The main organic acid detected in P. digitatum-decayed oranges was galacturonic acid produced as a consequence of host maceration in the rot development process. However, the obtained results showed that this acid was not responsible for the pH decrease in decayed orange tissue. The mixture of malic and citric acids could at least contribute to the acidification of P. digitatum-decayed oranges. The pH decrease in P. expansum decayed apples is related to the accumulation of gluconic and fumaric acids. The pH of oranges and apples was not affected when the non-host pathogen was not able to macerate the tissues. However, different organic acid contents were detected in comparison to healthy tissues. The main organic acids detected in P. expansum-oranges were oxalic and gluconic and in P. digitatum-apples were citric, gluconic and galacturonic. Further research is needed to identify the pathogenicity factors of both fungi because the contribution of organic acids has profound implications. Copyright © 2014 Elsevier B.V. All rights reserved.

  12. ‘JAFFA’ SWEET ORANGE PLANTS GRAFTED ONTO FIVE ROOTSTOCKS

    Directory of Open Access Journals (Sweden)

    ELÍDIO LILIANO CARLOS BACAR

    2017-12-01

    Full Text Available ABSTRACT Low genetic diversity of citrus scion and rootstock cultivars makes the crop more vulnerable to diseases and pests. The objective of this study was to evaluate the performance of ‘Jaffa’ sweet orange grafted onto five rootstocks over six harvests in subtropical conditions in the north of Paraná state, Brazil. The experiment used a randomized block design, with six replications and two trees per plot, spaced at 7.0 m x 4.0 m. The rootstocks were: ‘Rangpur’ lime, ‘Cleopatra’ and ‘Sunki’ mandarins, ‘Fepagro C-13’ citrange, and ‘Swingle’ citrumelo. The variables evaluated were vigor, yield, and yield efficiency of the trees as well as the physical and chemical characteristics of the fruits. Data were subjected to analysis of variance, complemented by Scott-Knott test at 5% probability. The smallest tree canopy for ‘Jaffa’ sweet orange plants was induced by the ‘Rangpur’ lime rootstock. The trees had the same cumulative yield performance over six seasons for all rootstocks. The best yield efficiency for ‘Jaffa’ sweet orange trees was provided by ‘Fepagro C-13’ citrange rootstock. With regard to fruit quality, no differences were observed among the rootstocks and the ‘Jaffa’ sweet orange fruits met the standards required by the fresh fruit market and the fruit processing industry.

  13. Improvement of biogas production from orange peel waste by leaching of limonene.

    Science.gov (United States)

    Wikandari, Rachma; Nguyen, Huong; Millati, Ria; Niklasson, Claes; Taherzadeh, Mohammad J

    2015-01-01

    Limonene is present in orange peel wastes and is known as an antimicrobial agent, which impedes biogas production when digesting the peels. In this work, pretreatment of the peels to remove limonene under mild condition was proposed by leaching of limonene using hexane as solvent. The pretreatments were carried out with homogenized or chopped orange peel at 20-40°C with orange peel waste and hexane ratio (w/v) ranging from 1 : 2 to 1 : 12 for 10 to 300 min. The pretreated peels were then digested in batch reactors for 33 days. The highest biogas production was achieved by treating chopped orange peel waste and hexane ratio of 12 : 1 at 20°C for 10 min corresponding to more than threefold increase of biogas production from 0.061 to 0.217 m(3) methane/kg VS. The solvent recovery was 90% using vacuum filtration and needs further separation using evaporation. The hexane residue in the peel had a negative impact on biogas production as shown by 28.6% reduction of methane and lower methane production of pretreated orange peel waste in semicontinuous digestion system compared to that of untreated peel.

  14. Investigating the effect of antioxidant extract from orange peel on lipids oxidation

    Directory of Open Access Journals (Sweden)

    Uduak G. AKPAN*

    2015-12-01

    Full Text Available This research involved investigation of the extraction yield and antioxidant property of orange peel on lipid oxidation. Orange peel was oven dried, grinded to powder and extraction procedure carried out using methanol as solvent in a soxhlet extractor. The effects of time and temperature on the extraction process were considered and results obtained showed an optimum extraction temperature and time of 50ºC and 120 minutes respectively. X-ray fluorescence analysis of the orange peel extract showed that potassium and calcium are the major elements by percentag mposition of 55.5 and 32.65 respectively. In studying the effects of oran eel extract on the melon oil sample, peroxide, free fatty acid and pH analysis were carried out for a period of 60 day. The result obtained confirmed the of ability orange peel extract as antioxidant agent.

  15. Current perspective of yellowish-orange pigments from microorganisms- a review

    OpenAIRE

    Aruldass , Claira Arul; Dufossé , Laurent; Ahmad , Wan Azlina

    2018-01-01

    International audience; Natural yellowish-orange pigments are derived from bacteria, yeasts, fungi and microalgae, including Chryseobacterium, Monascus and Chlorella. The purpose of this review is to provide an overview of these pigments in various aspects towards exploiting them for numerous functions. These pigments are produced in various shades of yellow-orange and categorised as carotenoids, anthraquinones, zeaxanthin, flexirubin and other compounds. They served as alternative colourants...

  16. 7 CFR 319.56-44 - Untreated grapefruit, sweet oranges, and tangerines from Mexico for processing.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 5 2010-01-01 2010-01-01 false Untreated grapefruit, sweet oranges, and tangerines... QUARANTINE NOTICES Fruits and Vegetables § 319.56-44 Untreated grapefruit, sweet oranges, and tangerines from Mexico for processing. Untreated grapefruit (Citrus paradisi), sweet oranges (Citrus sinensis), and...

  17. 77 FR 3326 - Cancellation of Environmental Impact Statement in Orange County, NC

    Science.gov (United States)

    2012-01-23

    ... DEPARTMENT OF TRANSPORTATION Federal Highway Administration Cancellation of Environmental Impact Statement in Orange County, NC AGENCY: Federal Highway Administration (FHWA), North Carolina Department of... US 70 Business and US 70 Bypass in Orange County, North Carolina. The project is now cancelled...

  18. Human melioidosis reported by ProMED

    Directory of Open Access Journals (Sweden)

    Katherinn Melissa Nasner-Posso

    2015-06-01

    Conclusions: Internet-based reporting systems such as ProMED are useful to gather information and synthesize knowledge on emerging infections. Although certain areas need to be improved, ProMED provided good information about melioidosis.

  19. The synthesis of isotopic fluorine and iodine-labeled COX-II inhibitor and in vitro validation

    Energy Technology Data Exchange (ETDEWEB)

    An, Gwang Gil; Lee, Tae Sub; Lee, Kyo Chul; Moon, Byung Seok; Choi, Chang Woon; Chun, Kwon Soo [Korea Institute of Radiological and Medical Sciences, Seoul (Korea, Republic of)

    2005-07-01

    In these day, NASIDs (non-steroidal antiinflammatory drugs) such as aspirin, diclofenac and ibuprofen are the most common medications used to reduce pain and inflammation. However, they act by inhibiting both COX-I and COX-II which can cause serious gastrointestinal side effects such as ulcers, stomach perforations and bleeds. COX-I produces prostaglandins believed to be responsible for the protection of the stomach lining. However, COX-II produces prostaglandins believed to be responsible for pain and inflammation. Recently, the most widely studied selective COX-II inhibitor such as celecoxib and rofecoxib' one work by inhibiting the effect of COX-II on pain and inflammation without inhibiting COX-I which protects gastrointestinal lining.

  20. Musikalsk leg med formgivning, timing og vitalitetsformer

    DEFF Research Database (Denmark)

    Holck, Ulla

    2015-01-01

    Ifølge de Udviklingsorienterede Social-Pragmatiske Interventionsformer til børn med Autisme Spektrum Forstyrrelse er en legende indfaldsvinkel, hvor man følger barnets lead, den mest effektive til at engagere yngre børn med autisme eller børn med svær autisme i et gensidigt samspil. Artiklen...

  1. Orange roughy: their age unlocked by radioisotopes

    International Nuclear Information System (INIS)

    Fenton, G.; Ritz, D.

    1992-01-01

    A radiometric method was developed and applied to try and solve the question of age for orange roughy, currently the primary target species in the south east trawl fishery. The method involved measuring the natural levels of the radioactive elements radium-226 and lead-210 present in the otolith of the fish. Radium-226 is chemically similar to calcium and, as such, is taken up by fish and laid-down in their otoliths as the fish grows. It was found that orange roughy is a very slow growing and long-lived species with fish 38-40 cm SL ranging between 77 and 149 years old. The results also indicated that maturity is around 32 years which occurs at about 32 cm SL. 4 refs., 1 tab., ills

  2. Med-E-Tel

    National Research Council Canada - National Science Library

    Lievens, Frank; Jordanova, Malina

    2006-01-01

    .... The Med-e-Tel 2006 conference program covered over 130 presentations on topics such as homecare and health management, healthcare challenges, tele-education, eHealth in developing countries, telecardiology...

  3. Med-E-Tel

    National Research Council Canada - National Science Library

    Lievens, Frank; Jordanova, Malina

    2006-01-01

    ..., and more. The Med-e-Tel 2006 exhibition showcased products and technologies in the areas of medication compliance, home telehealth and vital sign monitoring, clinical software, electronic medical records...

  4. COX-2 disruption leads to increased central vasopressin stores and impaired urine concentrating ability in mice

    DEFF Research Database (Denmark)

    Norregaard, Rikke; Madsen, Kirsten Morill; Hansen, Pernille Bl

    2011-01-01

    It was hypothesized that cyclooxygenase-2 (COX-2) activity promotes urine concentrating ability through stimulation of vasopressin (AVP) release after water deprivation (WD). COX-2-deficient (COX-2(-/-), C57BL/6) and wild-type (WT) mice were water deprived for 24 h, and water balance, central AVP m...... osmolality in COX-2(-/-) mice irrespective of gender. Hypothalamic AVP mRNA level increased and was unchanged between COX-2(-/-) and WT after WD. AVP peptide content was higher in COX-2(-/-) compared with WT. At baseline, plasma AVP concentration was elevated in conscious chronically catheterized COX-2......(-/-) mice, but after WD plasma AVP was unchanged between COX-2(-/-) and WT mice (43 ± 11 vs. 70 ± 16 pg/ml). Renal V2 receptor abundance was downregulated in COX-2(-/-) mice. Medullary interstitial osmolality increased and did not differ between COX-2(-/-) and WT after WD. Aquaporin-2 (AQP2; cortex...

  5. 78 FR 75359 - Waterway Suitability Assessment for Construction and Operation of Liquefied Gas Terminals; Orange...

    Science.gov (United States)

    2013-12-11

    ... Assessment for Construction and Operation of Liquefied Gas Terminals; Orange, TX AGENCY: Coast Guard, DHS... waterfront facility handling and storing Liquefied Hazardous Gas (LHG) at its Orange, Texas facility. The... LHG marine traffic in the associated waterway. INVISTA, S.a.r.l. located in Orange, Texas submitted an...

  6. Orange-Pigmented Sputum as a Manifestation of Smoke Grenade Inhalation Injury.

    Science.gov (United States)

    Chatzivasiloglou, Fotini; Katsenos, Stamatis; Psara, Anthoula; Tsintiris, Konstantinos

    2016-01-01

    A 34-year-old man presented with scanty hemoptysis, orange-colored expectoration, and mild dyspnea. He was in an enclosed building taking part in a military training exercise inhaling an orange-colored smoke from a smoke grenade ignition. His symptoms developed immediately after the initial exposure but he sought medical assistance 20 hours later because of their persistence. Fiberoptic bronchoscopy was performed revealing diffuse inflammatory tracheobronchial tree with streaky orange-pigmented secretions in the trachea and both main-stem bronchi. Acute tracheobronchitis was diagnosed and the patient was treated with nebulized bronchodilators and intravenous corticosteroids showing complete recovery. To our knowledge, this is the first well-documented report of inhalation injury induced by a smoke bomb explosion including potassium chlorate oxidizer and Sudan I and presenting with orange-pigmented sputum production. Smoke inhalation injury is associated with significant morbidity and mortality. The heterogeneity of the smoke and the large variety of the resulting symptoms may be the reason why a definition, specific diagnostic criteria, and therapeutic guidelines are still lacking.

  7. Expression of Beta-catenin, COX-2 and iNOS in Colorectal Cancer: Relevance of COX-2 and iNOS Inhibitors for Treatment in Malaysia

    Directory of Open Access Journals (Sweden)

    Seok Kwan Hong

    2004-01-01

    Conclusions: The accumulation of β-catenin does not seem to be sufficient to activate pathways that lead to increased COX-2 and iNOS expression. A high proportion of colorectal cancers were found to express COX-2 and a significant number produced iNOS, suggesting that their inhibitors may be potentially useful as chemotherapeutic agents in the management of colorectal cancer.

  8. Bond and CDS Pricing via the Stochastic Recovery Black-Cox Model

    Directory of Open Access Journals (Sweden)

    Albert Cohen

    2017-04-01

    Full Text Available Building on recent work incorporating recovery risk into structural models by Cohen & Costanzino (2015, we consider the Black-Cox model with an added recovery risk driver. The recovery risk driver arises naturally in the context of imperfect information implicit in the structural framework. This leads to a two-factor structural model we call the Stochastic Recovery Black-Cox model, whereby the asset risk driver At defines the default trigger and the recovery risk driver Rt defines the amount recovered in the event of default. We then price zero-coupon bonds and credit default swaps under the Stochastic Recovery Black-Cox model. Finally, we compare our results with the classic Black-Cox model, give explicit expressions for the recovery risk premium in the Stochastic Recovery Black-Cox model, and detail how the introduction of separate but correlated risk drivers leads to a decoupling of the default and recovery risk premiums in the credit spread. We conclude this work by computing the effect of adding coupons that are paid continuously until default, and price perpetual (consol bonds in our two-factor firm value model, extending calculations in the seminal paper by Leland (1994.

  9. Red orange: experimental models and epidemiological evidence of its benefits on human health.

    Science.gov (United States)

    Grosso, Giuseppe; Galvano, Fabio; Mistretta, Antonio; Marventano, Stefano; Nolfo, Francesca; Calabrese, Giorgio; Buscemi, Silvio; Drago, Filippo; Veronesi, Umberto; Scuderi, Alessandro

    2013-01-01

    In recent years, there has been increasing public interest in plant antioxidants, thanks to the potential anticarcinogenic and cardioprotective actions mediated by their biochemical properties. The red (or blood) orange (Citrus sinensis (L.) Osbeck) is a pigmented sweet orange variety typical of eastern Sicily (southern Italy), California, and Spain. In this paper, we discuss the main health-related properties of the red orange that include anticancer, anti-inflammatory, and cardiovascular protection activities. Moreover, the effects on health of its main constituents (namely, flavonoids, carotenoids, ascorbic acid, hydroxycinnamic acids, and anthocyanins) are described. The red orange juice demonstrates an important antioxidant activity by modulating many antioxidant enzyme systems that efficiently counteract the oxidative damage which may play an important role in the etiology of numerous diseases, such as atherosclerosis, diabetes, and cancer. The beneficial effects of this fruit may be mediated by the synergic effects of its compounds. Thus, the supply of natural antioxidant compounds through a balanced diet rich in red oranges might provide protection against oxidative damage under differing conditions and could be more effective than, the supplementation of an individual antioxidant.

  10. Toxic Epidemics: Agent Orange Sickness in Vietnam and the United States.

    Science.gov (United States)

    Uesugi, Tak

    2016-01-01

    Social scientists studying toxic epidemics have often endeavored to shed light on the differences between scientists' and nonscientists' epistemic perspectives. Yet, little attention has been paid to the processes through which a toxic epidemic emerges as a phenomenon. A Luoi Valley of Central Vietnam was extensively sprayed with chemical defoliants (including Agent Orange) during the Vietnam War. The latent toxic effects of these chemicals, however, went largely unnoticed until the late 1990s. By juxtaposing the history through which the notion of "Agent Orange Sickness" emerged in the United States with an ethnographic study of A Luoi, I explore the notion of poison under which Agent Orange became recognizable as a poison.

  11. Characterization and Sequencing of MT-Cox1 Gene in Khorasan ...

    African Journals Online (AJOL)

    The aim of this study was to investigate the nucleotide sequence of COX1 gene in mitochondrial genome of Khorasan native chicken and detect the possible mutations in the genome. For this purpose, after sampling and extracting DNA from the whole blood samples, the COX1 gene was amplified using specific primers and ...

  12. COX-2 and PPAR-γ confer cannabidiol-induced apoptosis of human lung cancer cells.

    Science.gov (United States)

    Ramer, Robert; Heinemann, Katharina; Merkord, Jutta; Rohde, Helga; Salamon, Achim; Linnebacher, Michael; Hinz, Burkhard

    2013-01-01

    The antitumorigenic mechanism of cannabidiol is still controversial. This study investigates the role of COX-2 and PPAR-γ in cannabidiol's proapoptotic and tumor-regressive action. In lung cancer cell lines (A549, H460) and primary cells from a patient with lung cancer, cannabidiol elicited decreased viability associated with apoptosis. Apoptotic cell death by cannabidiol was suppressed by NS-398 (COX-2 inhibitor), GW9662 (PPAR-γ antagonist), and siRNA targeting COX-2 and PPAR-γ. Cannabidiol-induced apoptosis was paralleled by upregulation of COX-2 and PPAR-γ mRNA and protein expression with a maximum induction of COX-2 mRNA after 8 hours and continuous increases of PPAR-γ mRNA when compared with vehicle. In response to cannabidiol, tumor cell lines exhibited increased levels of COX-2-dependent prostaglandins (PG) among which PGD(2) and 15-deoxy-Δ(12,14)-PGJ(2) (15d-PGJ(2)) caused a translocation of PPAR-γ to the nucleus and induced a PPAR-γ-dependent apoptotic cell death. Moreover, in A549-xenografted nude mice, cannabidiol caused upregulation of COX-2 and PPAR-γ in tumor tissue and tumor regression that was reversible by GW9662. Together, our data show a novel proapoptotic mechanism of cannabidiol involving initial upregulation of COX-2 and PPAR-γ and a subsequent nuclear translocation of PPAR-γ by COX-2-dependent PGs.

  13. COX-2 gene expression in colon cancer tissue related to regulating factors and promoter methylation status

    International Nuclear Information System (INIS)

    Asting, Annika Gustafsson; Carén, Helena; Andersson, Marianne; Lönnroth, Christina; Lagerstedt, Kristina; Lundholm, Kent

    2011-01-01

    Increased cyclooxygenase activity promotes progression of colorectal cancer, but the mechanisms behind COX-2 induction remain elusive. This study was therefore aimed to define external cell signaling and transcription factors relating to high COX-2 expression in colon cancer tissue. Tumor and normal colon tissue were collected at primary curative operation in 48 unselected patients. COX-2 expression in tumor and normal colon tissue was quantified including microarray analyses on tumor mRNA accounting for high and low tumor COX-2 expression. Cross hybridization was performed between tumor and normal colon tissue. Methylation status of up-stream COX-2 promoter region was evaluated. Tumors with high COX-2 expression displayed large differences in gene expression compared to normal colon. Numerous genes with altered expression appeared in tumors of high COX-2 expression compared to tumors of low COX-2. COX-2 expression in normal colon was increased in patients with tumors of high COX-2 compared to normal colon from patients with tumors of low COX-2. IL1β, IL6 and iNOS transcripts were up-regulated among external cell signaling factors; nine transcription factors (ATF3, C/EBP, c-Fos, Fos-B, JDP2, JunB, c-Maf, NF-κB, TCF4) showed increased expression and 5 (AP-2, CBP, Elk-1, p53, PEA3) were decreased in tumors with high COX-2. The promoter region of COX-2 gene did not show consistent methylation in tumor or normal colon tissue. Transcription and external cell signaling factors are altered as covariates to COX-2 expression in colon cancer tissue, but DNA methylation of the COX-2 promoter region was not a significant factor behind COX-2 expression in tumor and normal colon tissue

  14. COX-2 gene expression in colon cancer tissue related to regulating factors and promoter methylation status

    Directory of Open Access Journals (Sweden)

    Lagerstedt Kristina

    2011-06-01

    Full Text Available Abstract Background Increased cyclooxygenase activity promotes progression of colorectal cancer, but the mechanisms behind COX-2 induction remain elusive. This study was therefore aimed to define external cell signaling and transcription factors relating to high COX-2 expression in colon cancer tissue. Method Tumor and normal colon tissue were collected at primary curative operation in 48 unselected patients. COX-2 expression in tumor and normal colon tissue was quantified including microarray analyses on tumor mRNA accounting for high and low tumor COX-2 expression. Cross hybridization was performed between tumor and normal colon tissue. Methylation status of up-stream COX-2 promoter region was evaluated. Results Tumors with high COX-2 expression displayed large differences in gene expression compared to normal colon. Numerous genes with altered expression appeared in tumors of high COX-2 expression compared to tumors of low COX-2. COX-2 expression in normal colon was increased in patients with tumors of high COX-2 compared to normal colon from patients with tumors of low COX-2. IL1β, IL6 and iNOS transcripts were up-regulated among external cell signaling factors; nine transcription factors (ATF3, C/EBP, c-Fos, Fos-B, JDP2, JunB, c-Maf, NF-κB, TCF4 showed increased expression and 5 (AP-2, CBP, Elk-1, p53, PEA3 were decreased in tumors with high COX-2. The promoter region of COX-2 gene did not show consistent methylation in tumor or normal colon tissue. Conclusions Transcription and external cell signaling factors are altered as covariates to COX-2 expression in colon cancer tissue, but DNA methylation of the COX-2 promoter region was not a significant factor behind COX-2 expression in tumor and normal colon tissue.

  15. At lede med latter

    DEFF Research Database (Denmark)

    Møller, Mette

    2014-01-01

    "Det sagde hun også i går!" Platte vitser, der lægger op til den karakteristiske 'bodom-tchi'-trommelyd, behøver ikke være lederens eneste forsøg på at udvise humoristisk sans på talerstolen. For humor kan være meget andet og gøre meget mere for lederen end at score billige point med en spontan s...... spøg. Humor kan skabe klarhed over en pointe, skabe lederens image og skabe sammenhold i organisationen. Uden trommelyd, men med mange andre effekter i spil....

  16. Predicting clicks of PubMed articles.

    Science.gov (United States)

    Mao, Yuqing; Lu, Zhiyong

    2013-01-01

    Predicting the popularity or access usage of an article has the potential to improve the quality of PubMed searches. We can model the click trend of each article as its access changes over time by mining the PubMed query logs, which contain the previous access history for all articles. In this article, we examine the access patterns produced by PubMed users in two years (July 2009 to July 2011). We explore the time series of accesses for each article in the query logs, model the trends with regression approaches, and subsequently use the models for prediction. We show that the click trends of PubMed articles are best fitted with a log-normal regression model. This model allows the number of accesses an article receives and the time since it first becomes available in PubMed to be related via quadratic and logistic functions, with the model parameters to be estimated via maximum likelihood. Our experiments predicting the number of accesses for an article based on its past usage demonstrate that the mean absolute error and mean absolute percentage error of our model are 4.0% and 8.1% lower than the power-law regression model, respectively. The log-normal distribution is also shown to perform significantly better than a previous prediction method based on a human memory theory in cognitive science. This work warrants further investigation on the utility of such a log-normal regression approach towards improving information access in PubMed.

  17. Effects of tooth whitening and orange juice on surface properties of dental enamel.

    Science.gov (United States)

    Ren, Yan-Fang; Amin, Azadeh; Malmstrom, Hans

    2009-06-01

    To study the effects of 6% H2O2 activated with LED light on surface enamel as compared to orange juice challenges in vitro. A total of 40 human enamel discs were incubated in saliva overnight to allow pellicle formation and then divided into three groups: 15 for whitening treatments, 15 for orange juice immersions and 10 for normal saline controls. Baseline microhardness was measured with a microhardness Knoop indenter (50g, 10s) and surface topography was evaluated with a focus-variation 3D scanning microscopy. Enamel discs were treated with H2O2 or orange juice for 20 min each cycle for five cycles to simulate daily treatment with the products for 5 days. The discs were stored in saliva between treatment cycles. Microhardness and surface topography were evaluated again after treatments. Changes in microhardness and in surface area roughness (Sa), mean maximum peak-to-valley distance (Sz) and the developed surface area ratio (Sdr) were compared before and after treatments (t-test) and among groups (ANOVA). Enamel surface hardness decreased by 84% after orange juice immersion but no statistically significant changes were observed in the whitening and control groups. Surface topography changed significantly only in the orange juice group as shown by increased Sa (1.2 microm vs. 2.0 microm), Sz (7.7 microm vs. 10.2 microm) and Sdr (2.8% vs. 6.0%). No such changes were observed in the whitening and control groups. In comparison to orange juice challenges, the effects of 6% H2O2 on surface enamel are insignificant. Orange juice erosion markedly decreased hardness and increased roughness of enamel.

  18. Effect of Chitosan on some Microbial and chemical quality of orange juice

    Directory of Open Access Journals (Sweden)

    M Jeiranikhameneh

    2013-02-01

    Full Text Available One of the biggest obstacles towards orange juice trade is its limited shelf-life. Microbial spoilage is among the reasons for declining the quality of orange juice during storage. The purpose of this study was to determine the impact of chitosan as a natural preservative to increase the shelf-life of orange juice. For this, different concentrations of chitosan including 0, 0.4, 0.8, 1, 1.2, 1.6 and 2 g/L were used. During the storage periodmicrobial (total bacterial count and chemical(Brix and pH characteristics were assessed.Resultsshowed that higher concentrations of chitosan significantly (p

  19. Agent Orange exposure and attributed health effects in Vietnam veterans.

    Science.gov (United States)

    Young, Alvin L; Cecil, Paul F

    2011-07-01

    Serum dioxin studies of Vietnam (VN) veterans, military historical records of tactical herbicide use in Vietnam, and the compelling evidence of the photodegradation of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and other aspects of environmental fate and low bioavailability of TCDD are consistent with few, if any, ground troop veterans being exposed to Agent Orange. That conclusion, however, is contrary to the presumption by the Department of Veterans Affairs (DVA) that military service in Vietnam anytime from January 9, 1962 to May 7, 1975 is a proxy for exposure to Agent Orange. The DVA assumption is inconsistent with the scientific principles governing determinations of disease causation. The DVA has nonetheless awarded Agent Orange-related benefits and compensation to an increasing number of VN veterans based on the presumption of exposure and the published findings of the Institute of Medicine that there is sufficient evidence of a "statistical association" (a less stringent standard than "causal relationship") between exposure to tactical herbicides or TCDD and 15 different human diseases. A fairer and more valid approach for VN veterans would have been to enact a program of "Vietnam experience" benefits for those seriously ill, rather than benefits based on the dubious premise of injuries caused by Agent Orange.

  20. Effect of drying conditions on the physical properties of impregnated orange peel

    Directory of Open Access Journals (Sweden)

    K. Manjarres-Pinzon

    2013-09-01

    Full Text Available Orange peel represents approximately 30-40 g/100g of the fresh fruit weight and could be used to develop value-added products. Hence, this study aims to evaluate the effects of drying conditions on the physical properties of orange peel impregnated with sucrose solution. The response surface method (RSM was used to optimize two parameters: drying temperature (35-55 ºC and air flow rate (2-3 m/s. The measured responses used to determine the effect of dying process conditions were: moisture content. drying time. total soluble solids. color and hardness. The dried orange peels from the optimal process were subjected to a sensory test by 60 consumers. The optimum conditions for the drying of orange peels were determined to obtain minimum hardness, moisture content and drying time for a w values below 0.6. The optimum conditions were found to be a dying temperature of 52.3 ºC and air flow rate of 2.0 m/s. At this point, drying time, hardness and moisture content were found to be 20 h, 78.4 N and 7.6%, respectively. The sensory results showed that consumers aged over 30 years old accepted well the dried orange peel.

  1. Improvement of Biogas Production from Orange Peel Waste by Leaching of Limonene

    Science.gov (United States)

    Wikandari, Rachma; Nguyen, Huong; Millati, Ria; Niklasson, Claes; Taherzadeh, Mohammad J.

    2015-01-01

    Limonene is present in orange peel wastes and is known as an antimicrobial agent, which impedes biogas production when digesting the peels. In this work, pretreatment of the peels to remove limonene under mild condition was proposed by leaching of limonene using hexane as solvent. The pretreatments were carried out with homogenized or chopped orange peel at 20–40°C with orange peel waste and hexane ratio (w/v) ranging from 1 : 2 to 1 : 12 for 10 to 300 min. The pretreated peels were then digested in batch reactors for 33 days. The highest biogas production was achieved by treating chopped orange peel waste and hexane ratio of 12 : 1 at 20°C for 10 min corresponding to more than threefold increase of biogas production from 0.061 to 0.217 m3 methane/kg VS. The solvent recovery was 90% using vacuum filtration and needs further separation using evaporation. The hexane residue in the peel had a negative impact on biogas production as shown by 28.6% reduction of methane and lower methane production of pretreated orange peel waste in semicontinuous digestion system compared to that of untreated peel. PMID:25866787

  2. Improvement of Biogas Production from Orange Peel Waste by Leaching of Limonene

    Directory of Open Access Journals (Sweden)

    Rachma Wikandari

    2015-01-01

    Full Text Available Limonene is present in orange peel wastes and is known as an antimicrobial agent, which impedes biogas production when digesting the peels. In this work, pretreatment of the peels to remove limonene under mild condition was proposed by leaching of limonene using hexane as solvent. The pretreatments were carried out with homogenized or chopped orange peel at 20–40°C with orange peel waste and hexane ratio (w/v ranging from 1 : 2 to 1 : 12 for 10 to 300 min. The pretreated peels were then digested in batch reactors for 33 days. The highest biogas production was achieved by treating chopped orange peel waste and hexane ratio of 12 : 1 at 20°C for 10 min corresponding to more than threefold increase of biogas production from 0.061 to 0.217 m3 methane/kg VS. The solvent recovery was 90% using vacuum filtration and needs further separation using evaporation. The hexane residue in the peel had a negative impact on biogas production as shown by 28.6% reduction of methane and lower methane production of pretreated orange peel waste in semicontinuous digestion system compared to that of untreated peel.

  3. Tracing phenolic compounds through manufacturing of edible films from orange and grapefruit peels

    OpenAIRE

    Hernández-Carrillo, J.G.; Valdez-Fragoso, A.; Welti-Chanes, J.; Mújica-Paz, H.

    2015-01-01

    Edible films naturally rich in phenolic compounds were prepared from orange and grapefruit peels. Free and total polyphenols were determined by Folin-Ciocalteau method and flavonoids were identified and quantified by HPLC in the manufacturing processes of films. Films from grapefruit and orange peel had 24.95 and 28.18 mg GAE/g (Gallic Acid Equivalents/g), respectively, retaining more than 50% of total phenolics from the raw material. Hesperidin (33.39 mg/g) was the main flavonoid in orange p...

  4. Metabolomic comparative analysis of the phloem sap of curry leaf tree (Bergera koenegii), orange jasmine (Murraya paniculata), and Valencia sweet orange (Citrus sinensis) supports their differential responses to Huanglongbing.

    Science.gov (United States)

    Killiny, Nabil

    2016-11-01

    Orange jasmine, Murraya paniculata and curry leaf tree, Bergera koenegii are alternative hosts for Diaphorina citri, the vector of Candidatus Liberibacter asiaticus (CLas), the pathogen of huanglongbing (HLB) in citrus. D. citri feeds on the phloem sap where CLas grows. It has been shown that orange jasmine was a better host than curry leaf tree to D. citri. In addition, CLas can infect orange jasmine but not curry leaf tree. Here, we compared the phloem sap composition of these 2 plants to the main host, Valencia sweet orange, Citrus sinensis. Phloem sap was analyzed by gas chromatography-mass spectrometry after trimethylsilyl derivatization. Orange jasmine was the highest in proteinogenic, non-proteinogenic amino acids, organic acids, as well as total metabolites. Valencia was the highest in mono- and disaccharides, and sugar alcohols. Curry leaf tree was the lowest in most of the metabolites as well as total metabolites. Interestingly, malic acid was high in Valencia and orange jasmine but was not detected in the curry leaf. On the other hand, tartaric acid which can prevent the formation of malic acid in Krebs cycle was high in curry leaf. The nutrient inadequacy of the phloem sap in curry leaf tree, especially the amino acids could be the reason behind the longer life cycle and the low survival of D. citri and the limitation of CLas growth on this host. Information obtained from this study may help in cultivation of CLas and development of artificial diet for rearing of D. citri.

  5. [Orange Platform].

    Science.gov (United States)

    Toba, Kenji

    2017-07-01

    The Organized Registration for the Assessment of dementia on Nationwide General consortium toward Effective treatment in Japan (ORANGE platform) is a recently established nationwide clinical registry for dementia. This platform consists of multiple registries of patients with dementia stratified by the following clinical stages: preclinical, mild cognitive impairment, early-stage, and advanced-stage dementia. Patients will be examined in a super-longitudinal fashion, and their lifestyle, social background, genetic risk factors, and required care process will be assessed. This project is also notable because the care registry includes information on the successful, comprehensive management of patients with dementia. Therefore, this multicenter prospective cohort study will contribute participants to all clinical trials for Alzheimer's disease as well as improve the understanding of individuals with dementia.

  6. Glyphosate Control of Orange and Brown Rusts in Glyphosate-Sensitive Sugarcane Cultivars

    Science.gov (United States)

    Technical Abstract: Brown and orange rust diseases cause substantial yield reductions on sugarcane (Saccharum spp.) in Florida and other regions where sugarcane is grown. Brown rust caused by Puccinia melanocephala Syd. & P. Syd has been present in Florida since 1978 and orange rust caused by Pucci...

  7. VIABILIDADE DO PÓLEN EM VARIEDADES DE LARANJA DOCE POLLEN VIABILITY IN SWEET ORANGE VARIETIES

    Directory of Open Access Journals (Sweden)

    Edson Tobias Domingues

    1999-01-01

    Full Text Available Uma vez que a polinização é um dos pontos decisivos para o crescimento e desenvolvimento do fruto, contribuindo com os gametas masculinos para a fecundação e determinando, na maioria das vezes, a fixação dos frutos em citros, torna-se necessário conhecer o grau de esterilidade masculina nas diferentes variedades de laranja doce para sua possível utilização em programas de melhoramento. A esterilidade é limitante para programas que envolvam a hibridação sexual, por outro lado possui sua importância econômica em citros induzindo menor número de sementes por fruto em certas variedades. Com a finalidade de caracterizar 44 variedades de laranja doce (Citrus sinensis [L.] osbeck quanto à viabilidade do pólen, foram coletadas anteras das variedades enxertadas sobre tangerineira Cleópatra. As variedades estudadas pertencem aos principais grupos de laranja doce: com acidez (como a laranja 'Pêra', de baixa acidez (como a laranja 'Lima', com umbigo (como a laranja 'Bahia' e sangüíneas (como a laranja 'Rubi Blood'. O percentual de pólen viável foi avaliado por meio da coloração com carmim acético a 25% e contagem sob microscópio ótico. Foram observados valores que variaram desde 12,0% para a 'Pêra Sem Sementes' até 88,8% para a variedade 'Hamlin Reserva'. Os clones de laranja 'Hamlin' mostraram maior percentual de pólen viável. Não foi observada presença de pólen para as variedades produtoras de laranjas de umbigo, originadas da variedade Bahia. As variedades 'Pêra', 'Valência' e 'Natal', as quais são as principais cultivares da citricultura paulista e nacional, apresentaram baixos percentuais de pólen viável.Pollination is one of the most critical points in fruit growth and development, contributing with male gametes for fertilization and determine, greatly, fruit setting in citrus. It is necessary to evaluate male sterility in sweet orange varieties for their possible use in breeding programs. The sterility limits

  8. PERBANDINGAN TRANSFORMASI BOX-COX DAN REGRESI KUANTIL MEDIAN DALAM MENGATASI HETEROSKEDASTISITAS

    Directory of Open Access Journals (Sweden)

    NI WAYAN YUNI CAHYANI

    2015-01-01

    Full Text Available Ordinary least square (OLS is a method that can be used to estimate the parameter in linear regression analysis. There are some assumption which should be satisfied on OLS, one of this assumption is homoscedasticity, that is the variance of error is constant. If variance of the error is unequal that so-called heteroscedasticity. The presence heteroscedasticity can cause estimation with OLS becomes inefficient. Therefore, heteroscedasticity shall be overcome. There are some method that can used to overcome heteroscedasticity, two among those are Box-Cox power transformation and median quantile regression. This research compared Box-Cox power transformation and median quantile regression to overcome heteroscedasticity. Applied Box-Cox power transformation on OLS result ????2point are greater, smaller RMSE point and confidencen interval more narrow, therefore can be concluded that applied of Box-Cox power transformation on OLS better of median quantile regression to overcome heteroscedasticity.

  9. PERBANDINGAN TRANSFORMASI BOX-COX DAN REGRESI KUANTIL MEDIAN DALAM MENGATASI HETEROSKEDASTISITAS

    Directory of Open Access Journals (Sweden)

    NI WAYAN YUNI CAHYANI

    2015-03-01

    Full Text Available Ordinary least square (OLS is a method that can be used to estimate the parameter in linear regression analysis. There are some assumption which should be satisfied on OLS, one of this assumption is homoscedasticity, that is the variance of error is constant. If variance of the error is unequal that so-called heteroscedasticity. The presence heteroscedasticity can cause estimation with OLS becomes inefficient. Therefore, heteroscedasticity shall be overcome. There are some method that can used to overcome heteroscedasticity, two among those are Box-Cox power transformation and median quantile regression. This research compared Box-Cox power transformation and median quantile regression to overcome heteroscedasticity. Applied Box-Cox power transformation on OLS result ????2point are greater, smaller RMSE point and confidencen interval more narrow, therefore can be concluded that applied of Box-Cox power transformation on OLS better of median quantile regression to overcome heteroscedasticity.

  10. Effect of fermentation and subsequent pasteurization processes on amino acids composition of orange juice.

    Science.gov (United States)

    Cerrillo, I; Fernández-Pachón, M S; Collado-González, J; Escudero-López, B; Berná, G; Herrero-Martín, G; Martín, F; Ferreres, F; Gil-Izquierdo, A

    2015-06-01

    The fermentation of fruit produces significant changes in their nutritional composition. An orange beverage has been obtained from the controlled alcoholic fermentation and thermal pasteurization of orange juice. A study was performed to determine the influence of both processes on its amino acid profile. UHPLC-QqQ-MS/MS was used for the first time for analysis of orange juice samples. Out of 29 amino acids and derivatives identified, eight (ethanolamine, ornithine, phosphoethanolamine, α-amino-n-butyric acid, hydroxyproline, methylhistidine, citrulline, and cystathionine) have not previously been detected in orange juice. The amino acid profile of the orange juice was not modified by its processing, but total amino acid content of the juice (8194 mg/L) was significantly increased at 9 days of fermentation (13,324 mg/L). Although the pasteurization process produced partial amino acid degradation, the total amino acid content was higher in the final product (9265 mg/L) than in the original juice, enhancing its nutritional value.

  11. Agent Orange exposure and cancer incidence in Korean Vietnam veterans: a prospective cohort study.

    Science.gov (United States)

    Yi, Sang-Wook; Ohrr, Heechoul

    2014-12-01

    During the Vietnam War, US and allied military sprayed approximately 77 million liters of tactical herbicides including Agent Orange, contaminated with 2,3,7,8-tetrachlorodibenzo-p-dioxin. To the authors' knowledge, few studies to date have examined the association between Agent Orange exposure and cancer incidence among Korean veterans who were exposed to Agent Orange during the Vietnam War. An Agent Orange exposure index, based on the proximity of the veteran's military unit to the area that was sprayed with Agent Orange, was developed using a geographic information system-based model. Cancer incidence was followed for 180,251 Vietnam veterans from 1992 through 2003. After adjustment for age and military rank, high exposure to Agent Orange was found to significantly increase the risk of all cancers combined (adjusted hazards ratio [aHR], 1.08). Risks for cancers of the mouth (aHR, 2.54), salivary glands (aHR, 6.96), stomach (aHR, 1.14), and small intestine (aHR, 2.30) were found to be significantly higher in the high-exposure group compared with the low-exposure group. Risks for cancers of all sites combined (aHR, 1.02) and for cancers of the salivary glands (aHR, 1.47), stomach (aHR, 1.03), small intestine (aHR, 1.24), and liver (aHR, 1.02) were elevated with a 1-unit increase in the exposure index. Exposure to Agent Orange several decades earlier may increase the risk of cancers in all sites combined, as well as several specific cancers, among Korean veterans of the Vietnam War, including some cancers that were not found to be clearly associated with exposure to Agent Orange in previous cohort studies primarily based on Western populations. © 2014 American Cancer Society.

  12. One-step green synthesis of bimetallic Fe/Pd nanoparticles used to degrade Orange II

    Energy Technology Data Exchange (ETDEWEB)

    Luo, Fang; Yang, Die; Chen, Zuliang, E-mail: zuliang.chen@newcastle.edu.au; Megharaj, Mallavarapu; Naidu, Ravendra

    2016-02-13

    Highlights: • Green synthesis of bimetallic Fe/Pd NPs was firstly reported using the one-step method. • 98.0% of Orange II was removed by Fe/Pd NPs, but only 16.0% by Fe NPs. • Fe/Pd NPs with a diameter ranging from 10 to 100 nm were observed. • Removing Orange II using Fe/Pd NPs involved both adsorption and catalytic degradation. - Abstract: To reduce cost and enhance reactivity, bimetallic Fe/Pd nanoparticles (NPs) were firstly synthesized using grape leaf aqueous extract to remove Orange II. Green synthesized bimetallic Fe/Pd NPs (98.0%) demonstrated a far higher ability to remove Orange II in 12 h compared to Fe NPs (16.0%). Meanwhile, all precursors, e.g., grape leaf extract, Fe{sup 2+} and Pd{sup 2+}, had no obvious effect on removing Orange II since less than 2.0% was removed. Kinetics study revealed that the removal rate fitted well to the pseudo-first-order reduction and pseudo-second-order adsorption model, meaning that removing Orange II via Fe/Pd NPs involved both adsorption and catalytic reduction. The remarkable stability of Fe/Pd NPs showed the potential application for removing azo dyes. Furthermore, Scanning Electron Microscopy (SEM) and Fourier Transform Infrared Spectroscopy (FTIR) confirmed the changes in Fe/Pd NPs before and after reaction with Orange II. High Performance Liquid Chromatography–Mass Spectrum (HPLC–MS) identified the degraded products in the removal of Orange II, and finally a removal mechanism was proposed. This one-step strategy using grape leaf aqueous extract to synthesize Fe/Pd NPs is simple, cost-effective and environmentally benign, making possible the large-scale production of Fe/Pd NPs for field remediation.

  13. 76 FR 30754 - Notice of Availability of the Draft Environmental Impact Statement: Riverside and Orange Counties...

    Science.gov (United States)

    2011-05-26

    ... Environmental Impact Statement: Riverside and Orange Counties, CA AGENCY: Federal Highway Administration (FHWA... Riverside and Orange Counties, California. DATES: The comment period for the State Route 91 Corridor... in Riverside and Orange Counties. The State Route 91 Corridor Improvement Project proposes to widen...

  14. Akupunktur til patienten med kvalme og opkastning i forbindelse med kemoterapi - er der evidens for dette?

    DEFF Research Database (Denmark)

    Pedersen, Birgith; Sørensen, Lene Bundgaard; Stricker, Lisbeth

    2008-01-01

      Patienter, der får kemoterapi med højemetogene stoffer lider stadig af kvalme og opkastning trods understøttende behandling med moderne antieemtika som 5HT3-antagonister eksempelvis ondansetron. Akupunkturstimulation anvendes for flere lidelser i sundhedsvæsenet og det undersøges om der er evid...

  15. DUKUNGAN KELUARGA DAN KEPATUHAN MINUM OBAT PADA ORANG DENGAN DIABETES MELITUS

    Directory of Open Access Journals (Sweden)

    Yetti Kristianingrum

    2011-06-01

    Full Text Available Penelitian ini bertujuan untuk menguji hubungan antara dukungan keluarga dengan kepatuhan minum obat. Subjek penelitian adalah orang dengan diabetes melitus, sebanyak 60 orang. Data variabel penelitian diungkap dengan Skala Dukungan Keluarga dan Skala Kepatuhan Minum Obat. Teknik analisis data yang digunakan adalah korelasi Product Moment dari Karl Pearson. Berdasarkan analisis data diperoleh koefisien sebesar r = 0,707 (p

  16. Efek ekstrak daun singkong (Manihot utilissima terhadap ekspresi COX-2 pada monosit yang dipapar LPS E.coli (The effect of Manihot utilissima extracts on COX-2 expression of monocytes induced by LPS E. coli

    Directory of Open Access Journals (Sweden)

    Zahara Meilawaty

    2013-12-01

    Full Text Available Background: Periodontal disease is a common and widespread disease in the community. Gram negative bacteria have a role inperiodontitis. These bacteria secrete a variety of products such as endotoxin lipopolysaccharide (LPS, which causes the occurrenceof inflammation or infection. The body defense responses are neutrophils and mononuclear cells (monocytes and macrophages. Inresponse to defense mechanism, the body will be expressed enzyme cyclooxygenase (COX which functions convert arachidonic acidto prostaglandins. Cassava leaf cells known to play a role in reducing inflammation, but the mechanism for inhibiting COX-2, is notknown. Purpose: The study was aimed to determine the effect of cassava leaf extract (Manihot utilissima on expression of enzyme COX-2 in monocytes which were exposed by LPS E. coli. Methods: This study was in vitro experimental studies with the design of posttestonly control group design. The sample was the cassava leaves extract (Manihot utilissima at concentration of 12.5 % and 25 %. Theexpression of COX-2 was determined by immunocytochemistry method. Isolated monocytes were incubated in cassava leaf extract, andthen exposed to LPS, after washing imunostaning procedure was performed using a monoclonal antibody (MAb anti-human COX-2.The research data was the number of monocytes that express COX-2. Results: Expression of COX-2 in the group cassava leaf extractwas higher than the group that induced by LPS E. coli only. Conclusion: Cassava leaf extract did not inhibit the expression of COX-2in monocytes which were exposed by LPS E. coli.Latar belakang: Penyakit periodontal merupakan penyakit umum dan tersebar luas di masyarakat. Bakteri yang banyak berperanpada periodontitis adalah Gram negatif. Bakteri ini mengeluarkan berbagai produk antara lain endotoksin lipopolisakarida (LPS yangmenyebabkan inflamasi atau infeksi. Respon pertahanan tubuh pertama adalah netrofil dan sel mononuklear (monosit dan makrofag.Pada respon

  17. Film dosimeters based on methylene blue and methyl orange in polyvinyl alcohol

    DEFF Research Database (Denmark)

    Chung, W.H.; Miller, A.

    1994-01-01

    Polyvinyl alcohol (PVA) films containing methylene blue and methyl orange are useful as gamma and electron radiation dosimeters. Absorbed doses should not exceed 40 kGy for methylene blue and 500 kGy for methyl orange. Because PVA is water-soluble, the films may be made without toxic solvents...

  18. 76 FR 54375 - Safety Zone; Thunder on the Gulf, Gulf of Mexico, Orange Beach, AL

    Science.gov (United States)

    2011-09-01

    ...-AA00 Safety Zone; Thunder on the Gulf, Gulf of Mexico, Orange Beach, AL AGENCY: Coast Guard, DHS... portion of the Gulf of Mexico for the waters off Orange Beach, Alabama. This action is necessary for the... conduct a high speed boat race on the Gulf of Mexico, south of Orange Beach, Alabama to occur from October...

  19. Technical development of PubMed Interact: an improved interface for MEDLINE/PubMed searches

    OpenAIRE

    Muin, Michael; Fontelo, Paul

    2006-01-01

    Abstract Background The project aims to create an alternative search interface for MEDLINE/PubMed that may provide assistance to the novice user and added convenience to the advanced user. An earlier version of the project was the 'Slider Interface for MEDLINE/PubMed searches' (SLIM) which provided JavaScript slider bars to control search parameters. In this new version, recent developments in Web-based technologies were implemented. These changes may prove to be even more valuable in enhanci...

  20. Secretory phospholipase A(2) induces delayed neuronal COX-2 expression compared with glutamate

    DEFF Research Database (Denmark)

    Kolko, Miriam; Nielsen, Marianne; Bazan, Nicolas G

    2002-01-01

    and immunohistochemistry. An up-regulation of COX-2, c-fos, and c-jun, but not COX-1, was observed around the lesion as well as in the neocortex 4 hr after the injection. Hippocampal up-regulation of COX-2 was seen in dentate gyrus 8 hr after injection. When glutamate was injected, up-regulation of the early...

  1. Chemometric techniques on evaluation of the flavor of irradiated orange juice concentrate

    International Nuclear Information System (INIS)

    Spoto, Marta Helena Fillet.

    1994-01-01

    The effects of storage temperature and time on can orange juice concentrated were studied for samples irradiated at 2.5, 5.0 and 7.5 kGy doses from a gamma-ray source as well as for untreated samples. All samples were stored at 0 0 C, 5 0 C and 25 0 C for periods of 1, 30, 60 and 90 days. The concentrated orange juice was subjected to sensorial evaluations and gas chromatographic analysis. The free profile technique was applied using eight trained panel applying the Quantitative Descriptive Analyses, using a 10 cm unstructured category scale for each attribute. Samples stored for more than one day showed a diminution in the orange attribute rating and correspondent increases in ratings for the bitterness, medicinal and cooked attributes. Storage at 0 0 C and 5 0 C showed smaller effects on the sweetness ratings as well as on the oily, acidic and medicinal flavor characteristics. In most cases increased radiation levels were accompanied by lower intensity of orange attribute values and higher intensity of bitter, medicinal and cooked attributes. Forty three chemical compounds were characterized. Mircene, octanal, δ-3-carene, limonene, citronelal, and neral were highly correlated and statistically significant correlation coefficients. All these components showed low, but 95% confidence significant level correlations with the orange attribute. On the other hand the correlated group of hexanal, octanol, oxidation products, terpinene-4-ol, cis-carveol, nerol, carvona, geraniol, perilyl alcohol and cariophilene substances can be associated the bitter, medicinal and cooked attributes of the irradiated orange juice concentrate. (author). 83 refs., 7 figs., 12 tabs

  2. Grateful Med: getting started.

    Science.gov (United States)

    Shearer, B; McCann, L; Crump, W J

    1990-01-01

    When a local medical library is not available, it is often necessary for physicians to discover alternate ways to receive medical information. Rural physicians, particularly, can make use of a computer program called Grateful Med that provides access to the same literature available to physicians in large cities. This program permits the user to perform database searches on the National Library of Medicine database (MEDLINE), corresponding to the primary index to medical literature, Index Medicus. In this article, we give the procedure for procuring a National Library of Medicine password and for making efficient use of the Grateful Med program.

  3. Red Orange: Experimental Models and Epidemiological Evidence of Its Benefits on Human Health

    Directory of Open Access Journals (Sweden)

    Giuseppe Grosso

    2013-01-01

    Full Text Available In recent years, there has been increasing public interest in plant antioxidants, thanks to the potential anticarcinogenic and cardioprotective actions mediated by their biochemical properties. The red (or blood orange (Citrus sinensis (L. Osbeck is a pigmented sweet orange variety typical of eastern Sicily (southern Italy, California, and Spain. In this paper, we discuss the main health-related properties of the red orange that include anticancer, anti-inflammatory, and cardiovascular protection activities. Moreover, the effects on health of its main constituents (namely, flavonoids, carotenoids, ascorbic acid, hydroxycinnamic acids, and anthocyanins are described. The red orange juice demonstrates an important antioxidant activity by modulating many antioxidant enzyme systems that efficiently counteract the oxidative damage which may play an important role in the etiology of numerous diseases, such as atherosclerosis, diabetes, and cancer. The beneficial effects of this fruit may be mediated by the synergic effects of its compounds. Thus, the supply of natural antioxidant compounds through a balanced diet rich in red oranges might provide protection against oxidative damage under differing conditions and could be more effective than, the supplementation of an individual antioxidant.

  4. A 'tiny-orange' spectrometer for electrons

    International Nuclear Information System (INIS)

    Silva, N.C. da.

    1990-01-01

    An tiny-orange electron spectrometer was designed and constructed using flat permanent magnets and a surface barrier detector. The transmission functions of different system configurations were determined for energies in the 200-1100 KeV range. A mathematical model for the system was developed. (L.C.J.A.)

  5. Human melioidosis reported by ProMED.

    Science.gov (United States)

    Nasner-Posso, Katherinn Melissa; Cruz-Calderón, Stefania; Montúfar-Andrade, Franco E; Dance, David A B; Rodriguez-Morales, Alfonso J

    2015-06-01

    There are limited sources describing the global burden of emerging diseases. A review of human melioidosis reported by ProMED was performed and the reliability of the data retrieved assessed in comparison to published reports. The effectiveness of ProMED was evaluated as a source of epidemiological data by focusing on melioidosis. Using the keyword 'melioidosis' in the ProMED search engine, all of the information from the reports and collected data was reviewed using a structured form, including the year, country, gender, occupation, number of infected individuals, and number of fatal cases. One hundred and twenty-four entries reported between January 1995 and October 2014 were identified. A total of 4630 cases were reported, with death reported in 505 cases, suggesting a misleadingly low overall case fatality rate (CFR) of 11%. Of 20 cases for which the gender was reported, 12 (60%) were male. Most of the cases were reported from Australia, Thailand, Singapore, Vietnam, and Malaysia, with sporadic reports from other countries. Internet-based reporting systems such as ProMED are useful to gather information and synthesize knowledge on emerging infections. Although certain areas need to be improved, ProMED provided good information about melioidosis. Copyright © 2015 The Authors. Published by Elsevier Ltd.. All rights reserved.

  6. Phylogenetic relationships of the Orang Asli and Iban of Malaysia based on maternal markers.

    Science.gov (United States)

    Ang, K C; Leow, J W H; Yeap, W K; Hood, S; Mahani, M C; Md-Zain, B M

    2011-04-12

    Malaysia remains as a crossroad of different cultures and peoples, and it has long been recognized that studying its population history can provide crucial insight into the prehistory of Southeast Asia as a whole. The earliest inhabitants were the Orang Asli in Peninsular Malaysia and the indigenous groups in Sabah and Sarawak. Although they were the earliest migrants in this region, these tribes are divided geographically by the South China Sea. We analyzed DNA sequences of 18 Orang Asli using mitochondrial DNA extracted from blood samples, each representing one sub-tribe, and from five Sarawakian Iban. Mitochondrial DNA was extracted from hair samples in order to examine relationships with the main ethnic groups in Malaysia. The D-loop region and cytochrome b genes were used as the candidate loci. Phylogenetic relationships were investigated using maximum parsimony and neighbor joining algorithms, and each tree was subjected to bootstrap analysis with 1000 replicates. Analyses of the HVS I region showed that the Iban are not a distinct group from the Orang Asli; they form a sub-clade within the Orang Asli. Based on the cytochrome b gene, the Iban clustered with the Orang Asli in the same clade. We found evidence for considerable gene flow between Orang Asli and Iban. We concluded that the Orang Asli, Iban and the main ethnic groups of Malaysia are probably derived from a common ancestor. This is in agreement with a single-route migration theory, but it does not dismiss a two-route migration theory.

  7. Disinfestation by irradiation of mangoes (Manguifera Indica L.) Kent and oranges (Citrus sinensis O.) Valencia

    International Nuclear Information System (INIS)

    Bustos Ramirez, M.E.

    1987-01-01

    The objectives in this work were to determine the minimum dose for radiation disinfestation of mangoes and oranges infested with Mexican fruit fly (Anastrepha ludens Loew) and to evaluate the quality of the fruits by organoleptic, chemical and physiological analysis of mangoes irradiated to 0.3, 0.6 and 1.0 kGy and storaged at 12 0 C during 15 days and oranges irradiated to 0.25, 0.6 and 1.0 kGy and storaged at 15 0 C during 21 days. To inhibit the development of larvaes in mangoes the minimum dose was 0.3 kGy and for oranges the dose was 0.45 kGy. The dose for the probit 9 security test were 0.43 kGy for mangoes and 0.63 kGy for oranges. The results of sensorial analysis in mangoes, indicated that there are no significative differences for the two panels: consumers or trained judges. The differences in the physiological and chemical analysis are greater for storage fruits than for the irradiated ones. At the end of the storage period the appearance of the irradiated mangoes was better than for the control. The observed differences in irradiated oranges were the presence of dark zones on the oranges peel which affect their quality. This effect is due to the irradiation in oranges not completely ripen. (author)

  8. Preparation of acridine orange-doped silica nanoparticles for pH measurement

    International Nuclear Information System (INIS)

    Liu, Jinshui; Zang, Lingjie; Wang, Yiru; Liu, Guoning

    2014-01-01

    Acridine orange was first encapsulated into silica shell via a facile reverse microemusion method to built core–shell fluorescent nanoparticles. The nanoparticles are all in spherical shape and have a narrow size distribution, and its application as a optical pH sensor has been demonstrated. This novel sensor is based on the pH-dependent fluorescence intensities of acridine orange in different pH value. The fluorescence intensity of acridine orange-doped silica nanoparticles was decreased by increasing pH value. Under optimum conditions, the changes of fluorescence intensity were proportional to the pH value in the range of 8.00–10.90. In addition, the sensor can be easily separated by centrifugation and adds no pollution to the environment compared to the free dyes. Furthermore, the effects of ionic strength and co-existing substances were proved to have little influence on the determination of pH. The sensor has been successfully applied to determine the pH of two artificial samples. Hence, the core–shell fluorescent nanoparticles show potential for practical application. -- Highlights: • Acridine orange was encapsulated into silica shell via a facile reverse microemusion method to built core–shell fluorescent nanoparticles. • The fluorescence intensity of acridine orange-doped silica nanoparticles was decreased by increasing pH value. • Its can be used as an optical pH sensor. • The sensor can be easily separated by centrifugation and adds no pollution to the environment compared to the free dyes. • The sensor has been successfully applied to determine the pH of artificial samples

  9. MED-SUV Data Life Cycle

    Science.gov (United States)

    Sangianantoni, Agata; Puglisi, Giuseppe; Spampinato, Letizia; Tulino, Sabrina

    2015-04-01

    The MED-SUV project aims to implement a digital e-infrastructure for data access in order to promote the monitoring and study of key volcanic regions prone to volcanic hazards, and thus improve hazard assessment, according to the rationale of Supersite GEO initiative to Vesuvius- Campi Flegrei and Mt Etna, currently identified as Permanent Supersites. The present study focuses on the life cycle of MED-SUV data generated in the first period of the project and highlights the managing approach, as well as the crucial steps to be implemented for ensuring that data will be properly and ethically managed and can be used and accessed from both MED-SUV and the external community. The process is conceived outlining how research data being handled as the project progresses, describing what data are collected, processed or generated and how these data are going to be shared and made available through Open Access. Data cycle begins with their generation and ends with the deposit in the digital infrastructure, its key series of stages through which MED-SUV data passes are Collection, Data citation, Categorization of data, Approval procedure, Registration of datasets, Application of licensing models, and PID assignment. This involves a combination of procedures and practices taking into account the scientific core mission and the priorities of the project as well as the potential legal issues related to the management and protection of the Intellectual Property. We believe that the implementation of this process constitutes a significant encouragement in MED-SUV data sharing and as a consequence a better understanding on the volcanic processes, hazard assessment and a better integration with other Supersites projects.

  10. Origin of colour stability in blue/orange/blue stacked phosphorescent white organic light-emitting diodes

    International Nuclear Information System (INIS)

    Kim, Sung Hyun; Jang, Jyongsik; Yook, Kyoung Soo; Lee, Jun Yeob

    2009-01-01

    The origin of colour stability in phosphorescent white organic light-emitting diodes (PHWOLEDs) with a blue/orange/blue stacked emitting structure was studied by monitoring the change in a recombination zone. A balanced recombination zone shift between the blue and the orange light-emitting layers was found to be responsible for the colour stability in the blue/orange/blue stacked PHWOLEDs.

  11. Prognostic significance of COX-2 and β-catenin in colorectal ...

    African Journals Online (AJOL)

    Amani Kazem

    2013-07-17

    Jul 17, 2013 ... (wingless type) signaling pathway, increased protein concentrations promote transcription of genes .... under a light microscope and the histological type of colorectal .... of signet ring cell carcinoma showed weak COX-2 positivity. 3.2. Analysis .... COX-2 expression was detected in other tumors, and was be-.

  12. Effect of sweet orange aroma on experimental anxiety in humans.

    Science.gov (United States)

    Goes, Tiago Costa; Antunes, Fabrício Dias; Alves, Péricles Barreto; Teixeira-Silva, Flavia

    2012-08-01

    The objective of this study was to evaluate the potential anxiolytic effect of sweet orange (Citrus sinensis) aroma in healthy volunteers submitted to an anxiogenic situation. Forty (40) male volunteers were allocated to five different groups for the inhalation of sweet orange essential oil (test aroma: 2.5, 5, or 10 drops), tea tree essential oil (control aroma: 2.5 drops), or water (nonaromatic control: 2.5 drops). Immediately after inhalation, each volunteer was submitted to a model of anxiety, the video-monitored version of the Stroop Color-Word Test (SCWT). Psychologic parameters (state-anxiety, subjective tension, tranquilization, and sedation) and physiologic parameters (heart rate and gastrocnemius electromyogram) were evaluated before the inhalation period and before, during, and after the SCWT. Unlike the control groups, the individuals exposed to the test aroma (2.5 and 10 drops) presented a lack of significant alterations (p>0.05) in state-anxiety, subjective tension and tranquillity levels throughout the anxiogenic situation, revealing an anxiolytic activity of sweet orange essential oil. Physiologic alterations along the test were not prevented in any treatment group, as has previously been observed for diazepam. Although more studies are needed to find out the clinical relevance of aromatherapy for anxiety disorders, the present results indicate an acute anxiolytic activity of sweet orange aroma, giving some scientific support to its use as a tranquilizer by aromatherapists.

  13. 77 FR 30504 - Certain Orange Juice From Brazil: Notice of Rescission of Antidumping Duty Administrative Review

    Science.gov (United States)

    2012-05-23

    ... DEPARTMENT OF COMMERCE International Trade Administration [A-351-840] Certain Orange Juice From... Administrative Review'' of the antidumping duty order on certain orange juice (OJ) from Brazil for a period of...\\ See Revocation of Antidumping Duty Order: Certain Orange Juice From Brazil, 77 FR 23659 (Apr. 20, 2012...

  14. A role for the deep orange and carnation eye color genes in lysosomal delivery in Drosophila.

    Science.gov (United States)

    Sevrioukov, E A; He, J P; Moghrabi, N; Sunio, A; Krämer, H

    1999-10-01

    Deep orange and carnation are two of the classic eye color genes in Drosophila. Here, we demonstrate that Deep orange is part of a protein complex that localizes to endosomal compartments. A second component of this complex is Carnation, a homolog of Sec1p-like regulators of membrane fusion. Because complete loss of deep orange function is lethal, the role of this complex in intracellular trafficking was analyzed in deep orange mutant clones. Retinal cells devoid of deep orange function completely lacked pigmentation and exhibited exaggerated multivesicular structures. Furthermore, a defect in endocytic trafficking was visualized in developing photoreceptor cells. These results provide direct evidence that eye color mutations of the granule group also disrupt vesicular trafficking to lysosomes.

  15. EFFECT OF USING NUTRITION MINERALS AND GROWTH SUBSTANCE ON PHYSICAL PROPERTIES OF ORANGE FRUITS

    Directory of Open Access Journals (Sweden)

    Tarek FOUDA

    2014-12-01

    Full Text Available This work was carried to investigate the characterization of orange fruits under using applications of nutrition minerals and one application of growth substance on physical properties of orange fruits at private farm in wadi el-netron, ELbehari governorate, Egypt during winter 2011to predict maturity stage of orange fruits . The physical properties including aspect ratio(AR, Area of flat surface(Af, Area of transverse surface (At, Arithmetic diameter (Da, Density (ρ, Geometric diameter (Dg, surface area (Sa, sphericity, Volume (V and weight and the results revealed that, the high increasing percentage of orange fruits were considered as follows 9.24, 17.08, 22.65, 9.70, 27.16, 9.70, 20.45, 6.38, 24.07 and 28.84 %

  16. farmers' perceptions of orange-fleshed sweetpotato

    African Journals Online (AJOL)

    Okello, Julius (CIP)

    generated using multi-stage sampling technique and involving 732 ..... and male respondents across the two intervention categories perceive ... that children do not mind the orange color of the OFSP as compared to the non- .... or as women's crop, use sweetpotato to bridge the hunger gap, and view its leaves as a.

  17. The Arabidopsis Mediator Complex Subunits MED16, MED14, and MED2 Regulate Mediator and RNA Polymerase II Recruitment to CBF-Responsive Cold-Regulated Genes[C][W][OPEN

    Science.gov (United States)

    Hemsley, Piers A.; Hurst, Charlotte H.; Kaliyadasa, Ewon; Lamb, Rebecca; Knight, Marc R.; De Cothi, Elizabeth A.; Steele, John F.; Knight, Heather

    2014-01-01

    The Mediator16 (MED16; formerly termed SENSITIVE TO FREEZING6 [SFR6]) subunit of the plant Mediator transcriptional coactivator complex regulates cold-responsive gene expression in Arabidopsis thaliana, acting downstream of the C-repeat binding factor (CBF) transcription factors to recruit the core Mediator complex to cold-regulated genes. Here, we use loss-of-function mutants to show that RNA polymerase II recruitment to CBF-responsive cold-regulated genes requires MED16, MED2, and MED14 subunits. Transcription of genes known to be regulated via CBFs binding to the C-repeat motif/drought-responsive element promoter motif requires all three Mediator subunits, as does cold acclimation–induced freezing tolerance. In addition, these three subunits are required for low temperature–induced expression of some other, but not all, cold-responsive genes, including genes that are not known targets of CBFs. Genes inducible by darkness also required MED16 but required a different combination of Mediator subunits for their expression than the genes induced by cold. Together, our data illustrate that plants control transcription of specific genes through the action of subsets of Mediator subunits; the specific combination defined by the nature of the stimulus but also by the identity of the gene induced. PMID:24415770

  18. A clockwork orange: The subject’s dissolution in modern society

    OpenAIRE

    Román González, Yenny Viviana

    2015-01-01

    The Anthony Burgess’ most amous work, A Clockwork Orange, was written in 1962. The great tale of he young “droog” Alex and his large histories of mugging people, beating up other gangs, raping women, and tealing from shops each night are he best reflection of Burgess constant preoccupation about the destructive and self-destructive aspects of men and ociety. Immortalized ten years after ts publication by the excellent Stanley Kubrick’s filmic version, A Clockwork Orange is a strong critic to ...

  19. 75 FR 29727 - Reorganization of Foreign-Trade Zone 37 Under Alternative Site Framework Orange County, NY

    Science.gov (United States)

    2010-05-27

    ... Zone 37 Under Alternative Site Framework Orange County, NY Pursuant to its authority under the Foreign... reorganization of general-purpose zones; Whereas, Orange County, New York, grantee of Foreign-Trade Zone 37... under the ASF with a service area of Orange County, New York, adjacent to the New York/Newark Customs...

  20. Tandlæger og personer med en spiseforstyrrelse

    DEFF Research Database (Denmark)

    Gehrt, Charlotte Astrid; Christensen, Lisa Bøge; Klinker, Sabine

    2016-01-01

    Mødet mellem tandlæge og patient med spiseforstyrrelse Introduktion og formål: Det er velkendt, at tandlæger kan spille en rolle i forhold til tidlig identifikation af en spiseforstyrrelse. Der erimidlertid begrænset viden om, hvilke forventninger tandlæger og personer med en spiseforstyrrelse har...... til mødet med hinanden i klinikken, og hvordan dette opleves. Undersøgelsens formål var derfor at få viden om mødet mellem tandlæger og personer med en spiseforstyrrelse. Materialer og metoder: Undersøgelsen var en tværsnitsundersøgelse baseret på to spørgeskemaer udarbejdet til henholdsvis tandlæger...... og personer med en spiseforstyrrelse. I alt 1.405 tandlæger deltog, mens 260 personer med en spiseforstyrrelse besvarede spørgeskemaet. Resultater: Tandlægerne havde større selvrapporteret viden om orale komplikationer ved en spiseforstyrrelse end om spiseforstyrrelser generelt. Størstedelen af...

  1. A study of DNA protective effect of orange juice supplementation.

    Science.gov (United States)

    Szeto, Yim Tong; To, Tai Lun; Pak, Sok Cheon; Kalle, Wouter

    2013-05-01

    The potential acute genoprotective effect of orange juice supplementation was investigated. Six healthy subjects (aged 33 to 60 years; 3 women and 3 men) were asked to drink 400 mL of commercial orange juice, which contained 100 mg vitamin C and 40.8 g sugar. Venous blood (2 mL) was taken before and 2 h after ingestion (test trial). A week later, the subjects were asked to repeat the trial by drinking 400 mL water with 100 mg vitamin C and 40.8 g glucose (control trial). Lymphocytes isolated from blood samples underwent comet assay on the day of collection. Pre- and postingestion DNA damage scores were measured in both the test and control trials. Results showed that there was a significant decrease in DNA damage induced by hydrogen peroxide after 2 h of supplementation with orange juice, and no change in baseline DNA damage. There was no significant decrease in the DNA damage in lymphocytes in the control trial.

  2. Juvenile life history of NE Atlantic orange roughy from otolith stable isotopes

    Science.gov (United States)

    Shephard, Samuel; Trueman, Clive; Rickaby, Rosalind; Rogan, Emer

    2007-08-01

    Otoliths of pre-recruit orange roughy ( Hoplostethus atlanticus) were sampled from different deep-water habitats ('flat' and 'hill') and areas (north and south) on the Porcupine Bank. Age-based profiles for stable isotopes of carbon (δ 13C) and oxygen (δ 18O) in these otoliths were developed, which provide a fish life-history record of water depth and metabolic activity. These profiles were consistent among all individuals implying endogenous (ontogenic) influences on the pattern. The data indicate that post-larval orange roughy are mesopelagic active foragers, early juvenile fish move into a low energy deep-demersal phase, and older pre-recruit orange roughy assume the habitat depth and metabolic rate typical of adults. Comparison of otolith stable isotope profiles among areas and habitats on the Porcupine Bank suggest that juvenile orange roughy from South 'hill' and 'flat' habitats experience differing temperature and metabolic status at certain life stages. This may reflect oceanographic and ecological divergence between the two environments and suggests fine-scale population structure that may reduce resilience to exploitation.

  3. A critical review of the epidemiology of Agent Orange/TCDD and prostate cancer.

    Science.gov (United States)

    Chang, Ellen T; Boffetta, Paolo; Adami, Hans-Olov; Cole, Philip; Mandel, Jack S

    2014-10-01

    To inform risk assessment and regulatory decision-making, the relationship between 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and prostate cancer requires clarification. This article systematically and critically reviews the epidemiologic evidence on the association between exposure to TCDD or Agent Orange, a TCDD-contaminated herbicide used during the Vietnam War, and prostate cancer risk. Articles evaluated include 11 studies of three cohorts, four case-control or cross-sectional studies, and three case-only studies of military veterans with information on estimated Agent Orange or TCDD exposure; 13 studies of seven cohorts, one case-control study, and eight proportionate morbidity or mortality studies of Vietnam veterans without information on Agent Orange exposure; 11 cohort studies of workers with occupational exposure to TCDD; and two studies of one community cohort with environmental exposure to TCDD. The most informative studies, including those of Vietnam veterans involved in Agent Orange spraying or other handling, herbicide manufacturing or spraying workers with occupational TCDD exposure, and community members exposed to TCDD through an industrial accident, consistently reported no significant increase in prostate cancer incidence or mortality. Only some potentially confounded studies of Vietnam veterans compared with the general population, studies with unreliable estimates of Agent Orange exposure, and analyses of selected subgroups of Vietnam veterans reported positive associations. Overall, epidemiologic research offers no consistent or convincing evidence of a causal relationship between exposure to Agent Orange or TCDD and prostate cancer. More accurate exposure assessment is needed in large epidemiologic studies to rule out a causal association more conclusively.

  4. Niacin and biosynthesis of PGD₂by platelet COX-1 in mice and humans.

    Science.gov (United States)

    Song, Wen-Liang; Stubbe, Jane; Ricciotti, Emanuela; Alamuddin, Naji; Ibrahim, Salam; Crichton, Irene; Prempeh, Maxwell; Lawson, John A; Wilensky, Robert L; Rasmussen, Lars Melholt; Puré, Ellen; FitzGerald, Garret A

    2012-04-01

    The clinical use of niacin to treat dyslipidemic conditions is limited by noxious side effects, most commonly facial flushing. In mice, niacin-induced flushing results from COX-1-dependent formation of PGD₂ and PGE₂ followed by COX-2-dependent production of PGE₂. Consistent with this, niacin-induced flushing in humans is attenuated when niacin is combined with an antagonist of the PGD₂ receptor DP1. NSAID-mediated suppression of COX-2-derived PGI₂ has negative cardiovascular consequences, yet little is known about the cardiovascular biology of PGD₂. Here, we show that PGD₂ biosynthesis is augmented during platelet activation in humans and, although vascular expression of DP1 is conserved between humans and mice, platelet DP1 is not present in mice. Despite this, DP1 deletion in mice augmented aneurysm formation and the hypertensive response to Ang II and accelerated atherogenesis and thrombogenesis. Furthermore, COX inhibitors in humans, as well as platelet depletion, COX-1 knockdown, and COX-2 deletion in mice, revealed that niacin evoked platelet COX-1-derived PGD₂ biosynthesis. Finally, ADP-induced spreading on fibrinogen was augmented by niacin in washed human platelets, coincident with increased thromboxane (Tx) formation. However, in platelet-rich plasma, where formation of both Tx and PGD₂ was increased, spreading was not as pronounced and was inhibited by DP1 activation. Thus, PGD₂, like PGI₂, may function as a homeostatic response to thrombogenic and hypertensive stimuli and may have particular relevance as a constraint on platelets during niacin therapy.

  5. Hvad skal vi med Etisk Råd?

    DEFF Research Database (Denmark)

    Ploug, Thomas; Gjerris, Mickey

    2012-01-01

    Det Etiske Råd har for os at se en væsentlig rolle at spille i et åbent og demokratisk samfund som det danske. Vi skal være med til at skabe grobund for de værdidiskussioner, som skal forme fremtidens samfund. Etik er at være i dialog – ikke at kaste med mudder.......Det Etiske Råd har for os at se en væsentlig rolle at spille i et åbent og demokratisk samfund som det danske. Vi skal være med til at skabe grobund for de værdidiskussioner, som skal forme fremtidens samfund. Etik er at være i dialog – ikke at kaste med mudder....

  6. OvidSP Medline-to-PubMed search filter translation: a methodology for extending search filter range to include PubMed's unique content.

    Science.gov (United States)

    Damarell, Raechel A; Tieman, Jennifer J; Sladek, Ruth M

    2013-07-02

    PubMed translations of OvidSP Medline search filters offer searchers improved ease of access. They may also facilitate access to PubMed's unique content, including citations for the most recently published biomedical evidence. Retrieving this content requires a search strategy comprising natural language terms ('textwords'), rather than Medical Subject Headings (MeSH). We describe a reproducible methodology that uses a validated PubMed search filter translation to create a textword-only strategy to extend retrieval to PubMed's unique heart failure literature. We translated an OvidSP Medline heart failure search filter for PubMed and established version equivalence in terms of indexed literature retrieval. The PubMed version was then run within PubMed to identify citations retrieved by the filter's MeSH terms (Heart failure, Left ventricular dysfunction, and Cardiomyopathy). It was then rerun with the same MeSH terms restricted to searching on title and abstract fields (i.e. as 'textwords'). Citations retrieved by the MeSH search but not the textword search were isolated. Frequency analysis of their titles/abstracts identified natural language alternatives for those MeSH terms that performed less effectively as textwords. These terms were tested in combination to determine the best performing search string for reclaiming this 'lost set'. This string, restricted to searching on PubMed's unique content, was then combined with the validated PubMed translation to extend the filter's performance in this database. The PubMed heart failure filter retrieved 6829 citations. Of these, 834 (12%) failed to be retrieved when MeSH terms were converted to textwords. Frequency analysis of the 834 citations identified five high frequency natural language alternatives that could improve retrieval of this set (cardiac failure, cardiac resynchronization, left ventricular systolic dysfunction, left ventricular diastolic dysfunction, and LV dysfunction). Together these terms reclaimed

  7. Ti år med formidlingspligt

    DEFF Research Database (Denmark)

    Meyer, Gitte

    2014-01-01

    Jubilæet blev markeret ved et symposium - men hvor var journalisterne, og hvor var forskerne? For få uger siden lagde TV 2 hus til et symposium om videnskab, formidling, journalistik og spin. Danske Videnskabsjournalister og Akademiet for de Tekniske Videnskaber tog med arrangementet et behjertet...... initiativ. De ville gøre status efter ti år med lovfæstet formidlingspligt på universiteterne. Samtidig lagde de op til et kritisk blik på universitetsverdenens kommunikationsafdelinger...

  8. Associations between COX-2 polymorphisms, blood cholesterol and risk of acute coronary syndrome

    DEFF Research Database (Denmark)

    Vogel, Ulla Birgitte; Segel, Stine; Dethlefsen, Claus

    2010-01-01

    the enzyme levels of COX-2, were associated with risk of ACS and if alcohol intake, smoking, and use of NSAID would modify the associations. We also wanted to investigate associations with blood lipid levels. Methods: A case–cohort study including 1031 ACS cases and a sub-cohort of 1703 persons was nested......), such that variant allele carriers with low alcohol intake had the lowest lipid levels. No statistically significant associations were observed in females. Conclusion: This study suggests that genetically determined COX-2 levels are associated with risk of ACS and blood lipid levels among males. No consistent......Background: The use of specific COX-2 inhibitors in cancer prevention has been associated with higher risk of acute coronary syndrome (ACS) and myocardial infarction. The aim of this study was to investigate if the polymorphisms COX2 T8473C (rs5275), and COX2 A-1195G (rs689466), which modify...

  9. Bygningsdele med celluloseuld og høruld

    DEFF Research Database (Denmark)

    Hansen, Ernst Jan de Place

    2001-01-01

    Resume af rapport med eksempler på bygningsdele med papir- eller hørisolering, der overholder bygningsreglementerne, udarbejdet af Dansk Brandteknisk Institut under Energistyrelsens udviklingsprogram "Miljø- og arbejdsmiljøvenlig isolering"...

  10. Immunohistochemical Expression of COX-2 in Uterine Serous Carcinoma Tissue

    Directory of Open Access Journals (Sweden)

    Joseph Menczer

    2016-03-01

    Material and methods. Cox-2 expression assessment by immunohistochemistry was performed on deparaffinized sections of paraffin-embedded tissue blocks of consecutive available USC uterine specimens of patients diagnosed from 2000 to 2014. Staining of more than 10% of the cells was considered positive. Staining intensity was graded on a 0 and ndash;3 scale. A scoring index was calculated by multiplying the intensity grade by the percentage of stained cells and considered low when it was equal to 1 or less and high when it was more than 1. Clinicopathological data were retrospectively abstracted from the records of the study group patients Results. The study comprised uterine specimens of 31 USC patients. Positive immunohistochemical staining was observed in 25 (80.6% USC specimens and a high score in 6 (19.4% of them. No association between immunohistochemical staining parameters and clinicopathological prognostic factors was observed. Conclusion. Although our findings should be verified in larger series, it seems that in view of the lack of association between immunohistochemical Cox-2 staining parameters in USC tissue and clinicopathological prognostic factors, this aggressive tumor is not a candidate for the use of selective Cox-2 inhibitors. Key words: Cox-2 expression, uterine carcinosarcoma, clinicopathological prognostic factors [J Interdiscipl Histopathol 2016; 4(1.000: 9-12

  11. Production of interstocked 'Pera' sweet orange nursey trees on 'Volkamer' lemon and 'Swingle' citrumelo rootstocks

    Directory of Open Access Journals (Sweden)

    Girardi Eduardo Augusto

    2006-01-01

    Full Text Available Incompatibility among certain citrus scion and rootstock cultivars can be avoided through interstocking. 'Pera' sweet orange (Citrus sinensis L. Osbeck nursery tree production was evaluated on 'Swingle' citrumelo (Poncirus trifoliata (L. Raf x Citrus paradisi Macf and 'Volkamer' lemon (Citrus volkameriana Pasquale incompatible rootstocks, using 'Valencia' and 'Hamlin' sweet oranges (Citrus sinensis L. Osbeck, 'Sunki' mandarin (Citrus sunki Hort. ex Tanaka, and 'Cleopatra' mandarin (Citrus reshni Hort. ex Tanaka as interstocks. Citrus nursery trees interstocked with 'Pera' sweet orange on both rootstocks were used as control. 'Swingle' citrumelo led to the highest interstock bud take percentage, the greatest interstock height and rootstock diameter, as well as the highest scion and root system dry weight. Percentage of 'Pera' sweet orange dormant bud eye was greater for plants budded on 'Sunki' mandarin than those budded on 'Valencia' sweet orange. No symptoms of incompatibility were observed among any combinations of rootstocks, interstocks and scion. Production cycle can take up to 17 months with higher plant discard.

  12. The Vulnerability of Community Capitals as a Threat to Orang Kuala Community Development in Malaysia

    Directory of Open Access Journals (Sweden)

    W. A. Amir Zal

    2014-05-01

    Full Text Available Community development emphasizes the utilization of community resources, also known as community capitals. However, it is often difficult for the community to access these resources; this difficulty retards development. Such is the predicament faced by the Orang Kuala, for whom coastal changes have resulted in greater difficulty in accessing their community resources. Nor is that the only threat that they face. For affirmation of these threats, this article lists two objectives, that is, to identify the accessibility of marine resources and to explain the types of threats faced by the Orang Kuala. To achieve these objectives, a study was conducted involving 51 household heads and 5 Orang Kuala informants, all of whom are residents of Sungai Layau village in Johor, Malaysia. This study uses a mixed-method approach, the concurrent embedded design, and also interview-based questionnaires and in-depth interviews simultaneously. For the first objective, the results show that the Orang Kuala can still attain community resources in the form of marine products. However, the Orang Kuala faced three types of threats: trends, shocks, and seasonal changes. The most significant threat to the Orang Kuala is the trend, that is, cost of living and social problems. These threats can reduce their chances of acquiring benefits from these community resources. This condition is called “vulnerability of community capitals.” The objective of this article is to put forth proposals on how to increase the capacity of community resources for the Orang Kuala so that their community can attain sustainable development. This proposal is based on the reality that the threats facing the Orang Kuala are at a critical level and that they are ready to accept changes.

  13. Seizure following the Use of the COX-2 Inhibitor Etoricoxib

    Directory of Open Access Journals (Sweden)

    Valentina Arnao

    2017-01-01

    Full Text Available We describe a case of epileptic seizures occurring after the use of a COX-2 inhibitor. A 61-year-old man was admitted to our department because of a generalized tonic-clonic seizure. EEG showed generalized slowdown of the activity. Neuroimaging and blood samples studies did not evidence alterations, but a careful pharmacological history revealed that the patient had taken the COX-2 inhibitor etoricoxib to treat lumbago few days before the onset of clinical symptoms. No seizures were reported after etoricoxib discontinuation and an EEG resulted to be normal two months after this. Conclusion. Knowing the pharmacological history of a patient is important for understanding the clinical presentation and selecting appropriate treatment. This is, to the best of our knowledge, the first reported case of generalized seizures associated with the use of COX-2 inhibitors.

  14. Carotenoid accumulation in orange-pigmented Capsicum annuum fruit, regulated at multiple levels

    Science.gov (United States)

    Rodriguez-Uribe, Laura; Guzman, Ivette; Rajapakse, Wathsala; Richins, Richard D.; O’Connell, Mary A.

    2012-01-01

    The pericarp of Capsicum fruit is a rich dietary source of carotenoids. Accumulation of these compounds may be controlled, in part, by gene transcription of biosynthetic enzymes. The carotenoid composition in a number of orange-coloured C. annuum cultivars was determined using HPLC and compared with transcript abundances for four carotenogenic enzymes, Psy, LcyB, CrtZ-2, and Ccs determined by qRT-PCR. There were unique carotenoid profiles as well as distinct patterns of transcription of carotenogenic enzymes within the seven orange-coloured cultivars. In one cultivar, ‘Fogo’, carrying the mutant ccs-3 allele, transcripts were detected for this gene, but no CCS protein accumulated. The premature stop termination in ccs-3 prevented expression of the biosynthetic activity to synthesize the capsanthin and capsorubin forms of carotenoids. In two other orange-coloured cultivars, ‘Orange Grande’ and ‘Oriole’, both with wild-type versions of all four carotenogenic enzymes, no transcripts for Ccs were detected and no red pigments accumulated. Finally, in a third case, the orange-coloured cultivar, Canary, transcripts for all four of the wild-type carotenogenic enzymes were readily detected yet no CCS protein appeared to accumulate and no red carotenoids were synthesized. In the past, mutations in Psy and Ccs have been identified as the loci controlling colour in the fruit. Now there is evidence that a non-structural gene may control colour development in Capsicum. PMID:21948863

  15. COX-2 verexpression in pretreatment biopsies predicts response of rectal cancers to neoadjuvant radiochemotherapy

    International Nuclear Information System (INIS)

    Smith, Fraser M.; Reynolds, John V.; Kay, Elaine W.; Crotty, Paul; Murphy, James O.; Hollywood, Donal; Gaffney, Eoin F.; Stephens, Richard B.; Kennedy, M. John

    2006-01-01

    Purpose: To determine the utility of COX-2 expression as a response predictor for patients with rectal cancer who are undergoing neoadjuvant radiochemotherapy (RCT). Methods and Materials: Pretreatment biopsies (PTB) from 49 patients who underwent RCT were included. COX-2 and proliferation in PTB were assessed by immunohistochemistry (IHC) and apoptosis was detected by TUNEL stain. Response to treatment was assessed by a 5-point tumor-regression grade (TRG) based on the ratio of residual tumor to fibrosis. Results: Good response (TRG 1 + 2), moderate response (TRG 3), and poor response (TRG 4 + 5) were seen in 21 patients (42%), 11 patients (22%), and 17 patients (34%), respectively. Patients with COX-2 overexpression in PTB were more likely to demonstrate moderate or poor response (TRG 3 + 4) to treatment than were those with normal COX-2 expression (p = 0.026, chi-square test). Similarly, poor response was more likely if patients had low levels of spontaneous apoptosis in PTBs (p = 0.0007, chi-square test). Conclusions: COX-2 overexpression and reduced apoptosis in PTB can predict poor response of rectal cancer to RCT. As COX-2 inhibitors are commercially available, their administration to patients who overexpress COX-2 warrants assessment in clinical trials in an attempt to increase overall response rates

  16. Social indsats til borgere med erfaring fra salg af sex

    DEFF Research Database (Denmark)

    Mehlsen, Line; Amilon, Anna; Henriksen, Theresa Dyrvig

    2017-01-01

    Formålet med denne guide er at give endnu flere kommuner inspiration og vejledning til, hvordan man kan implementere og arbejde med CTI-forløb over for borgere med prostitutionserfaring. Manglende viden om borgere med prostitutionserfaringer gør det svært for kommunerne at hjælpe borgerne med de ...

  17. Hemoglobinopathies and thalassemia screening among Senoi Orang Asli in Peninsular Malaysia

    Science.gov (United States)

    Rong, Danny Koh Xuan; Ismail, Endom; Sabudin, Raja Zahratul Azma Raja; Hussin, Noor Hamidah; Othman, Ainoon

    2015-09-01

    Orang Asli are the minority indigenous people in Peninsular Malaysia and can be divided into 3 main groups (Negrito, Senoi and Proto Malay) with different six sub-ethnics under each group. Within the Senoi group, the six sub-ethnics are sub-ethnic Mah Meri, Semoq Beri, Che Wong, Jah Hut, Semai and Temiar. This study was aimed to investigate the current prevalence of α- and β-thalassemia and hemoglobinopathies and their mutation types among all six sub-ethnics of Senoi Orang Asli. Blood samples from 685 Senoi participants were collected and sent immediately for routine full blood count analysis and hemoglobin sub-typing. Of 378 subjects screened, 7 subjects were found to be Hemoglobin E (HbE) beta thalassemia carriers, 13 beta thalassaemic, 35 Hemoglobin Constant Spring (HbCS) carriers, 6 compound HbE and HbCS carriers, 32 with HbE disease and 163 HbE heterozygote carriers. The findings of high HbE among Temiars and Jah Huts and high HbCS exclusively in Jah Huts in this study suggest distinct differences across sub-ethnics under Senoi group. Understanding of prevalence and wide spectrum of thalassemia and hemoglobinopathies among Senoi and Orang Asli is essential for national thalassaemia awareness and prevention program, especially in Orang Asli communities.

  18. Specifik mutation med nålestiksoperation

    DEFF Research Database (Denmark)

    Holme, Inger; Wendt, Toni; Brinch-Pedersen, Henrik

    2014-01-01

    Mutanter af byg er vigtige i forskningen og benyttes også, når der forædles nye sorter til dyrkning. Hidtil har det kun været muligt at inducere mutationer tilfældige steder i genomet. Med helt ny teknologi benyttes proteiner med betegnelsen TALENs til at inducere mutationer i helt specifikke...

  19. 77 FR 23659 - Revocation of Antidumping Duty Order: Certain Orange Juice From Brazil

    Science.gov (United States)

    2012-04-20

    ... Duty Order: Certain Orange Juice From Brazil AGENCY: Import Administration, International Trade...) initiated a sunset review of the antidumping duty order on certain orange juice (OJ) from Brazil.\\1\\ On...), the Department is revoking the antidumping duty order on OJ from Brazil. \\1\\ See Initiation of Five...

  20. 75 FR 20874 - Union Pacific Railroad Company-Abandonment Exemption-in Orange County, CA

    Science.gov (United States)

    2010-04-21

    ... DEPARTMENT OF TRANSPORTATION Surface Transportation Board [STB Docket No. AB-33 (Sub-No. 281X)] Union Pacific Railroad Company--Abandonment Exemption--in Orange County, CA Union Pacific Railroad....65 near the City of Brea, in Orange County, CA. The line traverses United States Postal Service Zip...

  1. Pesticide residues in orange fruit from citrus orchards in Nuevo Leon State, Mexico.

    Science.gov (United States)

    Suárez-Jacobo, Angela; Alcantar-Rosales, Victor Manuel; Alonso-Segura, Diana; Heras-Ramírez, Maria; Elizarragaz-De La Rosa, Dalau; Lugo-Melchor, Ofelia; Gaspar-Ramirez, Octavio

    2017-09-01

    Some international organisations established maximum residue limits (MRLs) in food to protect human health. Mexico lacks regulations in this matter, affecting national and international trade from agroindustry. The aim of this study was to diagnose pesticide residues in oranges from Nuevo Leon, México, in citrus orchards. In May 2014, 100 orange fruit samples were taken randomly from orchards and subjected to analysis for 93 pesticides at residual level by GC/QQQ-MS and LCQ-TOF-MS. Results showed the presence of 15 pesticide residues in the samples. The comparison of the residual levels of pesticides found in orange samples among the MRLs allowed by USA, EU and Japanese regulations demonstrated that all samples were below MRLs issued by USA and Japan. Some orange samples were above MRLs issued by the EU. This provides a basis to establish strategies in order to satisfy International Standards to protect human health and encourage Food Safety in Mexico.

  2. Effects of gamma irradiation and refrigeration on Saccharomyces cerevisiae growth in orange juice

    International Nuclear Information System (INIS)

    Domarco, R.E.; Spoto, M.H.F.; Walder, J.M.M.; Blumer, L.; Matraia, C.

    1996-01-01

    The effect of gamma radiation and of low temperatures was studied on yeast growth in orange juice. Concentrated orange juice (65 deg Brix) was diluted to 10.5 deg Brix and inoculated with commercial biological yeasts. The were irradiated with doses of 0.0 (control), 1.0, 1.5, 2.0, 2.5, 5.0 and 7.5 kGy (cobalt-60), with a 2.83 kGy/h dose rate. all the samples were stored at 0 deg, 5 deg and 25 deg C for periods of 1; 7; 14; 21; 30; 60 and 90 days of storage. Combined treatment of 1 kGy and refrigeration at 0 deg C was effective for orange juice conservation for 90 days of storage at 5 deg C. At 25 deg C only the two highest radiation doses (5.0 and 7.5 kGy) were effective to control yeast growth in orange juice. (author)

  3. Med sjefen på Facebook: En studie av ledere som er "venner" med sine ansatte

    OpenAIRE

    Jensen, Anita

    2014-01-01

    MR690 Masteroppgave i organisasjon og ledelse - utdanningsledelse Formålet med studien er å belyse hvordan aktiv bruk av sosiale medier, i dette tilfellet Facebook, påvirker relasjoner mellom mennesker. Hva skjer når en tar i bruk en websjanger som i utgangspunktet er umiddelbar og uformell, til jobbrelatert og mer formell kommunikasjon? Er det sjangeren eller relasjonen som endres? Søkelyset rettes mot ledere som er “venner” med sine medarbeidere, og problemstillingen er...

  4. Simultaneous confidence bands for Cox regression from semiparametric random censorship.

    Science.gov (United States)

    Mondal, Shoubhik; Subramanian, Sundarraman

    2016-01-01

    Cox regression is combined with semiparametric random censorship models to construct simultaneous confidence bands (SCBs) for subject-specific survival curves. Simulation results are presented to compare the performance of the proposed SCBs with the SCBs that are based only on standard Cox. The new SCBs provide correct empirical coverage and are more informative. The proposed SCBs are illustrated with two real examples. An extension to handle missing censoring indicators is also outlined.

  5. Citrus pulp pellets as an additive for orange bagasse silage

    Directory of Open Access Journals (Sweden)

    R. K. Grizotto

    2017-03-01

    Full Text Available This study evaluated the fermentation profile of orange bagasse ensiled with three levels of dry matter (DM using citrus pulp pellets as a moisture-absorbing additive. Thirty experimental silos (3 treatments, 5 storage times, 2 replicates were prepared using 25-liter plastic buckets containing orange bagasse and three levels of pelleted citrus pulp (0, 6% and 20% as additive. A completely randomized design with repeated measures over time was used. The periods of anaerobic storage were 3, 7, 14, 28 and 56 days. Natural orange bagasse contained 13.9% DM, which increased to 19.1% and 25.5% with the inclusion of 6% and 20% citrus pulp pellets, respectively. The apparent density was inversely correlated with DM content and a higher level of compaction (982 kg/m3 was observed in the mass ensiled with the lowest DM level (13.9%. Additionally, lower compaction (910 kg/m3 was found in the mass ensiled with the additive. The chemical composition of the mass ensiled with or without citrus pulp pellets did not differ significantly in terms of protein, ether extract, neutral detergent fiber, lignin or in vitro DM digestibility (P≥0.05, as expected. Thus, it was possible to analyze only the effect of the inclusion of citrus pulp pellets on the increase in DM content. The inclusion of 20% of the additive reduced (P<0.01 losses due to effluent (98% less and gas production (81% less compared to the control treatment at the end of the anaerobic storage period. In this treatment, a higher (P≤0.05 log number of lactic acid bacteria (4.61 log CFU/g was also observed compared to the other treatments, indicating that the increase in DM favored the growth of these bacteria. In addition, the low yeast count (about 1 log CFU/g sample and the pH below 4.0, which were probably due to the production of lactic and acetic acids, show that the orange bagasse is rich in fermentable soluble carbohydrates and is indicated for ensiling. In conclusion, orange bagasse can be

  6. Geograf med GIS som ledetråd

    DEFF Research Database (Denmark)

    Nielsen, Søren Zebitz

    2013-01-01

    Fra speciale om kortlægning af luft forurening med NO2 i troposfæren målt fra satellit til PhD studerende med fokus på forståelsen af menneskers bevægelsesmønstre i byer. GIS og geodata er den røde tråd der binder de brede interesser indenfor geografi en sammen for denne forskerlærling.......Fra speciale om kortlægning af luft forurening med NO2 i troposfæren målt fra satellit til PhD studerende med fokus på forståelsen af menneskers bevægelsesmønstre i byer. GIS og geodata er den røde tråd der binder de brede interesser indenfor geografi en sammen for denne forskerlærling....

  7. PubMed searches: overview and strategies for clinicians.

    Science.gov (United States)

    Lindsey, Wesley T; Olin, Bernie R

    2013-04-01

    PubMed is a biomedical and life sciences database maintained by a division of the National Library of Medicine known as the National Center for Biotechnology Information (NCBI). It is a large resource with more than 5600 journals indexed and greater than 22 million total citations. Searches conducted in PubMed provide references that are more specific for the intended topic compared with other popular search engines. Effective PubMed searches allow the clinician to remain current on the latest clinical trials, systematic reviews, and practice guidelines. PubMed continues to evolve by allowing users to create a customized experience through the My NCBI portal, new arrangements and options in search filters, and supporting scholarly projects through exportation of citations to reference managing software. Prepackaged search options available in the Clinical Queries feature also allow users to efficiently search for clinical literature. PubMed also provides information regarding the source journals themselves through the Journals in NCBI Databases link. This article provides an overview of the PubMed database's structure and features as well as strategies for conducting an effective search.

  8. A study on PubMed search tag usage pattern: association rule mining of a full-day PubMed query log.

    Science.gov (United States)

    Mosa, Abu Saleh Mohammad; Yoo, Illhoi

    2013-01-09

    The practice of evidence-based medicine requires efficient biomedical literature search such as PubMed/MEDLINE. Retrieval performance relies highly on the efficient use of search field tags. The purpose of this study was to analyze PubMed log data in order to understand the usage pattern of search tags by the end user in PubMed/MEDLINE search. A PubMed query log file was obtained from the National Library of Medicine containing anonymous user identification, timestamp, and query text. Inconsistent records were removed from the dataset and the search tags were extracted from the query texts. A total of 2,917,159 queries were selected for this study issued by a total of 613,061 users. The analysis of frequent co-occurrences and usage patterns of the search tags was conducted using an association mining algorithm. The percentage of search tag usage was low (11.38% of the total queries) and only 2.95% of queries contained two or more tags. Three out of four users used no search tag and about two-third of them issued less than four queries. Among the queries containing at least one tagged search term, the average number of search tags was almost half of the number of total search terms. Navigational search tags are more frequently used than informational search tags. While no strong association was observed between informational and navigational tags, six (out of 19) informational tags and six (out of 29) navigational tags showed strong associations in PubMed searches. The low percentage of search tag usage implies that PubMed/MEDLINE users do not utilize the features of PubMed/MEDLINE widely or they are not aware of such features or solely depend on the high recall focused query translation by the PubMed's Automatic Term Mapping. The users need further education and interactive search application for effective use of the search tags in order to fulfill their biomedical information needs from PubMed/MEDLINE.

  9. Δ9-THC-caused synaptic and memory impairments are mediated through COX-2 signaling

    Science.gov (United States)

    Yang, Hongwei; Tang, Ya-ping; Sun, Hao; Song, Yunping; Chen, Chu

    2013-01-01

    SUMMARY Marijuana has been used for thousands of years as a treatment for medical conditions. However, untoward side effects limit its medical value. Here we show that synaptic and cognitive impairments following repeated exposure to Δ9-tetrahydrocannabinol (Δ9-THC) are associated with the induction of cyclooxygenase-2 (COX-2), an inducible enzyme that converts arachidonic acid to prostanoids, in the brain. COX-2 induction by Δ9-THC is mediated via CB1 receptor-coupled G-protein βγ subunits. Pharmacological or genetic inhibition of COX-2 blocks down-regulation and internalization of glutamate receptor subunits and alterations of the dendritic spine density of hippocampal neurons induced by repeated Δ9-THC exposures. Ablation of COX-2 also eliminates Δ9-THC-impaired hippocampal long-term synaptic plasticity, spatial, and fear memories. Importantly, the beneficial effects of decreasing β-amyloid plaques and neurodegeneration by Δ9-THC in Alzheimer’s disease animals are retained in the presence of COX-2 inhibition. These results suggest that the applicability of medical marijuana would be broadened by concurrent inhibition of COX-2. PMID:24267894

  10. 76 FR 43344 - Certain Orange Juice From Brazil; Scheduling of a Full Five-Year Review Concerning the...

    Science.gov (United States)

    2011-07-20

    ... INTERNATIONAL TRADE COMMISSION [Investigation No. 731-TA-1089 (Review)] Certain Orange Juice From Brazil; Scheduling of a Full Five-Year Review Concerning the Antidumping Duty Order on Certain Orange... order on certain orange juice from Brazil would be likely to lead to continuation or recurrence of...

  11. Gamma-radiolysis of aqueous solutions of methyl orange and chrysoidine

    International Nuclear Information System (INIS)

    Khabarov, V.N.; Kozlov, L.L.; Panchenkov, G.M.

    1980-01-01

    Radiation-chemical bleaching of azo dyes of methyl orange and chrysoidine in aqueous and aqueous-alcoholic solutions under the effect of γ-radiation of 60 Co is studied. The effect of different additions and pH value of medium upon radiolysis of azo dyes is investigated. Radiation-chemical yields of the bleaching are determined. Quantitative connection between the initial yields of water radiolysis products and radiation yields of the bleaching of azo dyes is established. On the basis of the results obtained the most probable mechanism of methyl orange and chrysoidine bleaching is suggested

  12. Mars 2020 Entry, Descent and Landing Instrumentation (MEDLI2)

    Science.gov (United States)

    Bose, Deepak; Wright, Henry; White, Todd; Schoenenberger, Mark; Santos, Jose; Karlgaard, Chris; Kuhl, Chris; Oishi, TOmo; Trombetta, Dominic

    2016-01-01

    This paper will introduce Mars Entry Descent and Landing Instrumentation (MEDLI2) on NASA's Mars2020 mission. Mars2020 is a flagship NASA mission with science and technology objectives to help answer questions about possibility of life on Mars as well as to demonstrate technologies for future human expedition. Mars2020 is scheduled for launch in 2020. MEDLI2 is a suite of instruments embedded in the heatshield and backshell thermal protection systems of Mars2020 entry vehicle. The objectives of MEDLI2 are to gather critical aerodynamics, aerothermodynamics and TPS performance data during EDL phase of the mission. MEDLI2 builds up the success of MEDLI flight instrumentation on Mars Science Laboratory mission in 2012. MEDLI instrumentation suite measured surface pressure and TPS temperature on the heatshield during MSL entry into Mars. MEDLI data has since been used for unprecedented reconstruction of aerodynamic drag, vehicle attitude, in-situ atmospheric density, aerothermal heating, transition to turbulence, in-depth TPS performance and TPS ablation. [1,2] In addition to validating predictive models, MEDLI data has highlighted extra margin available in the MSL forebody TPS, which can potentially be used to reduce vehicle parasitic mass. MEDLI2 expands the scope of instrumentation by focusing on quantities of interest not addressed in MEDLI suite. The type the sensors are expanded and their layout on the TPS modified to meet these new objectives. The paper will provide key motivation and governing requirements that drive the choice and the implementation of the new sensor suite. The implementation considerations of sensor selection, qualification, and demonstration of minimal risk to the host mission will be described. The additional challenges associated with mechanical accommodation, electrical impact, data storage and retrieval for MEDLI2 system, which extends sensors to backshell will also be described.

  13. Comparism of the Properties and Yield of Bioethanol from Mango and Orange Waste

    Directory of Open Access Journals (Sweden)

    M. B. Maina

    2017-12-01

    Full Text Available The excessive consumption of fossil fuel particularly in urban areas due to transportation and industrial activities has greatly contributed to generation of high levels of pollution; therefore, a renewable eco-friendly energy source is required. The production of bioethanol from sugar extracted from waste fruit peels as an energy supply is renewable as the non-fossil carbon source used is readily replenished. Laboratory experiments were conducted to evaluate the chemical composition of fruit wastes of orange and Mango in order to explore their potential application in bio-ethanol production. Experimental production of Bioethanol from waste fruits of mango and orange was carried out after dilute acid pretreatment followed by enzymatic saccharification using saccharomyces cerevisiae for the fermentation process. Three samples of (mango waste fruit, orange waste fruit and mixture of mango and orange waste fruit 100g each was used for the same method of bio-ethanol extraction. A one factor factorial design involving fruit type was used to statistically analyze the fuel properties of the ethanol produced from the fruits waste. Analysis of variance (ANOVA shows that the observed difference were not significant for all the properties except that of the flash point which showed that the flash point of the produced bioethanol differ from that of the standard ethanol, which may be due to percentage of moisture present in the samples used. The highest yield of ethanol from sample A (mango waste was 19.98%, sample B (orange waste produced 19.17% while least yield of ethanol was from sample C (mango and orange waste which produced 17.38%.

  14. Clinicopathological features of mycosis fungoides in patients exposed to Agent Orange during the Vietnam War.

    Science.gov (United States)

    Jang, Min Soo; Jang, Jun Gyu; Han, Sang Hwa; Park, Jong Bin; Kang, Dong Young; Kim, Sang Tae; Suh, Kee Suck

    2013-08-01

    There are no reports on the clinicopathological features of mycosis fungoides (MF) among veterans exposed to Agent Orange, one of the herbicides used during the Vietnam War. To evaluate the clinical, histopathological and genotypic findings of Vietnam War veterans with MF and a positive history of exposure to Agent Orange, we performed a comparative clinicopathological study between MF patients with a history of Agent Orange exposure and those without a history of Agent Orange exposure. Twelve Vietnam War veterans with MF were identified. The mean interval from Agent Orange exposure to diagnosis was 24.5 years (range, 9-35). Skin lesions were significantly present on exposed and unexposed areas. Most patients (75%) experienced pruritus (mean visual analog scale score of 6.7). MF was manifested by plaques in 10 patients and by lichenification in five. Histopathological features of most cases were consistent with MF. Biopsy specimens also demonstrated irregular acanthosis (66.7%). In the comparative study, MF patients with a history of Agent Orange exposure differed significantly from those without exposure to Agent Orange in demographic and clinical characteristics. In addition, patients with exposure had an increased tendency for lesions in the exposed area. Notably, our patients showed a higher frequency (33.3%) of mycosis fungoides palmaris et plantaris than in previous studies. Histologically, irregular acanthosis was more frequently observed than ordinary MF. Our results indicate that dermatologists should pay close attention to these clinicopathological differences. Careful assessment of history of exposure to defoliants is warranted in some cases suspicious for MF. © 2013 Japanese Dermatological Association.

  15. Detection and classification of orange peel on polished steel surfaces by interferometric microscopy

    International Nuclear Information System (INIS)

    2T Research GmbH, Viktor Kaplan Strasse 2, Wiener Neustadt 2700 (Austria))" data-affiliation=" (AC2T Research GmbH, Viktor Kaplan Strasse 2, Wiener Neustadt 2700 (Austria))" >Miranda-Medina, M L; 2T Research GmbH, Viktor Kaplan Strasse 2, Wiener Neustadt 2700 (Austria))" data-affiliation=" (AC2T Research GmbH, Viktor Kaplan Strasse 2, Wiener Neustadt 2700 (Austria))" >Somkuti, P; 2T Research GmbH, Viktor Kaplan Strasse 2, Wiener Neustadt 2700 (Austria))" data-affiliation=" (AC2T Research GmbH, Viktor Kaplan Strasse 2, Wiener Neustadt 2700 (Austria))" >Steiger, B

    2013-01-01

    In this work, we provide a general description of the so-called orange peel defect produced on polished steel surfaces. By characterizing a prototype set of samples with various degrees orange peel, we attempt to create a simple model that allows the classification of additional samples through the study of surface parameters. On those surfaces, the orange peel structure has roughness amplitudes in the nanometer range. Detecting surface features on that range requires the implementation of a high-precision technique, such as phase shifting interferometry (PSI). Therefore, we can contribute to the improvement of the manufacturing of polished steel surfaces as well as to the quality control by using optical techniques.

  16. Med Antony Beevor i Ardennerne

    DEFF Research Database (Denmark)

    Christensen, Claus Bundgård

    2015-01-01

    Den storsælgende amerikanske historiker Antony Beevor tager i sin gennemgang af Anden Verdenskrigs slag denne gang læserne med til de sneklædte skove i Ardennerne, hvor tyskerne iværksatte deres sidste store offensiv på Vestfronten.......Den storsælgende amerikanske historiker Antony Beevor tager i sin gennemgang af Anden Verdenskrigs slag denne gang læserne med til de sneklædte skove i Ardennerne, hvor tyskerne iværksatte deres sidste store offensiv på Vestfronten....

  17. Ud at se med Erasmus

    DEFF Research Database (Denmark)

    Frandsen, Pernille

    2009-01-01

    Få lidt luft under vingerne, kom ud at møde udenlandske kolleger og se, hvordan man også kan lave uddannelsesbibliotek. Med begejstring fortæller tre bibliotekarer om deres oplevelser i det store udland – alt sammen finansieret af Erasmus.......Få lidt luft under vingerne, kom ud at møde udenlandske kolleger og se, hvordan man også kan lave uddannelsesbibliotek. Med begejstring fortæller tre bibliotekarer om deres oplevelser i det store udland – alt sammen finansieret af Erasmus....

  18. Assessment of the effectiveness of orange (Citrus reticulata) peel in the recovery of nickel from electroplating wastewater.

    Science.gov (United States)

    Hussein, Rim A

    2014-12-01

    Wastewater discharged from electroplating industry contains different concentrations of heavy metals, which when released into the environment pose a health hazard to human beings. The aim of this study was to assess the effectiveness of orange peel as an adsorbent in the recovery of Nickel (Ni) from electroplating wastewater. The effectiveness of orange peel as an adsorbent was assessed by determining the optimum conditions of adsorption (adsorbent dose, pH, and contact time), calculating the recovery percentage, and characterizing the orange peel sludge resulting from adsorption/desorption process as being hazardous or not. Under optimum conditions for adsorption, orange peel was found to be an effective adsorbent of Ni from electroplating wastewater. It achieved 59.28% removal of the metal from a solution containing 528 mg/l, at a dose of 60 g/l, at pH 7, and for 1-h contact time. The nickel uptake capacity of orange peel was calculated to be 5.2 mg/g. Using HCl for desorption of adsorbed Ni, a recovery of 44.46% of Ni discharged in the wastewater could be reached. Orange peel resulting from the adsorption/desorption process was characterized as being nonhazardous. Orange peel was found to be effective in the recovery of nearly half of the amount of Ni discharged in electroplating wastewater. Further studies are required to determine (a) the impact of the recovered NiCl2 solution on the quality of the plated product, (b) the effect of activation of orange peel on the adsorption process, and (c) the number of cycles during which orange peel can be reused as an effective adsorbent.

  19. An Investigation of Potential Fraud in Commercial Orange Juice Products in Malaysian Market by Cluster Analysis and Principal Component Analysis

    International Nuclear Information System (INIS)

    Keng, S.E.; Abbas Fadhl Mubarek Al-Karkhi; Mohd Khairuddin Mohd Talib; Azhar Mat Easa; Hoong, C.L.

    2015-01-01

    This study was triggered by Malaysia Ministry of Health to monitor quality of commercial orange juice products sold in Malaysia market. A total of 19 orange juice samples from 14 different brands of packed orange juice products and 5 different brands of fresh orange fruit juices were analyzed for total soluble solids content, total titratable acidity, sugar composition and amino acid profiles. Hierarchical Cluster analysis (HCA) and Principal component analysis (PCA) on amino acid composition alone allowed visual discrimination between fresh squeezed orange juices and commercial packed orange juices. Suspicion of mislabel was raised in cases of miss-classification. (author)

  20. A Monte Carlo Investigation of the Box-Cox Model and a Nonlinear Least Squares Alternative.

    OpenAIRE

    Showalter, Mark H

    1994-01-01

    This paper reports a Monte Carlo study of the Box-Cox model and a nonlinear least squares alternative. Key results include the following: the transformation parameter in the Box-Cox model appears to be inconsistently estimated in the presence of conditional heteroskedasticity; the constant term in both the Box-Cox and the nonlinear least squares models is poorly estimated in small samples; conditional mean forecasts tend to underestimate their true value in the Box-Cox model when the transfor...

  1. Determination of volatile, phenolic, organic acid and sugar components in a Turkish cv. Dortyol (Citrus sinensis L. Osbeck) orange juice.

    Science.gov (United States)

    Kelebek, Hasim; Selli, Serkan

    2011-08-15

    Orange flavour is the results of a natural combination of volatile compounds in a well-balanced system including sugars, acids and phenolic compounds. This paper reports the results of the first determination of aroma, organic acids, sugars, and phenolic components in Dortyol yerli orange juices. A total of 58 volatile components, including esters (nine), terpenes (19), terpenols (13), aldehydes (two), ketones (three), alcohols (four) and acids (eight) were identified and quantified in Dortyol yerli orange juice by GC-FID and GC-MS. Organic acids, sugars and phenolic compositions were also determined by HPLC methods. The major organic acid and sugar found were citric acid and sucrose, respectively. With regard to phenolics, 14 compounds were identified and quantified in the orange juice. Terpenes and terpenols were found as the main types of volatile components in Dortyol yerli orange juice. In terms of aroma contribution to orange juice, 12 compounds were prominent based on the odour activity values (OAVs). The highest OAV values were recorded for ethyl butanoate, nootkatone, linalool and DL-limonene. When we compare the obtained results of cv. Dortyol orange juice with the other orange juice varieties, the composition of Dortyol orange juice was similar to Valencia and Navel orange juices. Copyright © 2011 Society of Chemical Industry.

  2. Cox-nnet: An artificial neural network method for prognosis prediction of high-throughput omics data.

    Science.gov (United States)

    Ching, Travers; Zhu, Xun; Garmire, Lana X

    2018-04-01

    Artificial neural networks (ANN) are computing architectures with many interconnections of simple neural-inspired computing elements, and have been applied to biomedical fields such as imaging analysis and diagnosis. We have developed a new ANN framework called Cox-nnet to predict patient prognosis from high throughput transcriptomics data. In 10 TCGA RNA-Seq data sets, Cox-nnet achieves the same or better predictive accuracy compared to other methods, including Cox-proportional hazards regression (with LASSO, ridge, and mimimax concave penalty), Random Forests Survival and CoxBoost. Cox-nnet also reveals richer biological information, at both the pathway and gene levels. The outputs from the hidden layer node provide an alternative approach for survival-sensitive dimension reduction. In summary, we have developed a new method for accurate and efficient prognosis prediction on high throughput data, with functional biological insights. The source code is freely available at https://github.com/lanagarmire/cox-nnet.

  3. Activating PTEN by COX-2 inhibitors antagonizes radiation-induced AKT activation contributing to radiosensitization

    Energy Technology Data Exchange (ETDEWEB)

    Meng, Zhen [Central Laboratory, Peking University School and Hospital of Stomatology, 22 Zhongguancun Avenue South, Haidian District, Beijing 100081 (China); Department of Oral & Maxillofacial Surgery, Peking University School and Hospital of Stomatology, 22 Zhongguancun Avenue South, Haidian District, Beijing 100081 (China); Gan, Ye-Hua, E-mail: kqyehuagan@bjmu.edu.cn [Central Laboratory, Peking University School and Hospital of Stomatology, 22 Zhongguancun Avenue South, Haidian District, Beijing 100081 (China); Department of Oral & Maxillofacial Surgery, Peking University School and Hospital of Stomatology, 22 Zhongguancun Avenue South, Haidian District, Beijing 100081 (China)

    2015-05-01

    Radiotherapy is still one of the most effective nonsurgical treatments for many tumors. However, radioresistance remains a major impediment to radiotherapy. Although COX-2 inhibitors can induce radiosensitization, the underlying mechanism is not fully understood. In this study, we showed that COX-2 selective inhibitor celecoxib enhanced the radiation-induced inhibition of cell proliferation and apoptosis in HeLa and SACC-83 cells. Treatment with celecoxib alone dephosphorylated phosphatase and tensin homolog deleted on chromosome ten (PTEN), promoted PTEN membrane translocation or activation, and correspondingly dephosphorylated or inactivated protein kinase B (AKT). By contrast, treatment with radiation alone increased PTEN phosphorylation, inhibited PTEN membrane translocation and correspondingly activated AKT in the two cell lines. However, treatment with celecoxib or another COX-2 selective inhibitor (valdecoxib) completely blocked radiation-induced increase of PTEN phosphorylation, rescued radiation-induced decrease in PTEN membrane translocation, and correspondingly inactivated AKT. Moreover, celecoxib could also upregulate PTEN protein expression by downregulating Sp1 expression, thereby leading to the activation of PTEN transcription. Our results suggested that COX-2 inhibitors could enhance radiosensitization at least partially by activating PTEN to antagonize radiation-induced AKT activation. - Highlights: • COX-2 inhibitor, celecoxib, could enhance radiosensitization. • Radiation induced PTEN inactivation (phosphorylation) and AKT activation. • COX-2 inhibitor induced PTEN expression and activation, and inactivated AKT. • COX-2 inhibitor enhanced radiosensitization through activating PTEN.

  4. Ud med Freud, Marx og Lacan

    DEFF Research Database (Denmark)

    Clasen, Mathias

    2009-01-01

    Det er på høje tid, at humanister løsriver sig fra deres forældede teorier. Freud, Marx og Lacan skal erstattes med evolutionspsykologi, biologi og kognitionsvidenskab.......Det er på høje tid, at humanister løsriver sig fra deres forældede teorier. Freud, Marx og Lacan skal erstattes med evolutionspsykologi, biologi og kognitionsvidenskab....

  5. Early increased density of cyclooxygenase-2 (COX-2 immunoreactive neurons in Down syndrome

    Directory of Open Access Journals (Sweden)

    Maria Mulet

    2017-06-01

    Full Text Available Neuroinflammation is one of the hallmarks of Alzheimer’s disease. One of the enzymes involved in neuroinflammation, even in early stages of the disease, is COX-2, an inducible cyclooxygenase responsible for the generation of eicosanoids and for the generation of free radicals. Individuals with Down syndrome develop Alzheimer’s disease early in life. Previous studies pointed to the possible overexpression of COX-2 and correlated it to brain regions affected by the disease. We analysed the COX-2 expression levels in individuals with Down syndrome and in young, adult and old mice of the Ts65Dn mouse model for Down syndrome. We have observed an overexpression of COX-2 in both, Down syndrome individuals and mice. Importantly, mice already presented an overexpression of COX-2 at postnatal day 30, before neurodegeneration begins; which suggests that neuroinflammation may underlie the posterior neurodegeneration observed in individuals with Down syndrome and in Ts65Dn mice and could be a factor for the premature appearance of Alzheimer’s disease.

  6. Til julefrokost med Bjørn & Okay

    DEFF Research Database (Denmark)

    Smith-Sivertsen, Henrik

    2012-01-01

    I denne artikel vises med udgangspunkt i en beskrivelse af et specifikt arrangement med det danske danseorkester Bjørn & Okay, hvordan man optræder inden for denne særlige musiktradition. Bjørn & Okays performative udgangspunkt er, at de, trods en status som landskendt orkester med mange hits, i ...... the audience and constantly telling them what to do. At the same time he and the other musicians actively bond with the audience, both onstage and offstage, which helps building the spirit of community, which is the clear goal of the musical performance....

  7. Preparation of Metal Immobilized Orange Waste Gel for Arsenic(V Removal From Water

    Directory of Open Access Journals (Sweden)

    Biplob Kumar Biswas

    2014-05-01

    Full Text Available Abstract - The toxicity of arsenic is known to be a risk to aquatic flora and fauna and to human health even in relatively low concentration. In this research an adsorption gel was prepared from agricultural waste material (orange waste through simple chemical modification in the view to remove arsenic (V from water. Orange waste was crushed into small particles and saponified with Ca(OH2 to prepare saponified orange waste, which was further modified by immobilizing gadolinium(III to obtain desired adsorption material (Gd(III-immobilized SOW gel. The effective pH range for arsenic adsorption was found to be 7.5 – 8.5. Adsorption capacity of the gel was evaluated to be 0.45 mol-arsenic (V/kg. Dynamic adsorption of arsenic (V in column-mode was conducted and a dynamic capacity was found to be 0.39 mol/kg. Elution of arsenate was tested after complete saturation of the column packed with gadolinium-immobilized orange waste adsorption gel. A complete elution of arsenate was achieved with the help of 1 M HCl and 28 times pre-concentration factor was attained. This study showed that a cheap and abundant agro-industrial waste material could be successfully employed for the remediation of arsenic pollution in aquatic environment. Keywords: Arsenic; Orange waste; Gadolinium(III; Adsorption; Elution.

  8. The Empowerment of Orang Asli Women in the Tourism Industry in Lenggong, Perak

    Directory of Open Access Journals (Sweden)

    Yahaya Fatan Hamamah

    2014-01-01

    Full Text Available Women, particularly those of the Orang Asli community, without a doubt play an important role in the family. These duties and roles include organising household affairs, giving birth and raising children, tending to the house, preparing meals for the family and sorting out their children’s school affairs. However, their roles are not limited to duties or daily routines that are done only at home. In fact, women (especially Orang Asli women, are capable of far more activities that can empower them, especially in the Lenggong’s tourism industry. This paper explores Orang Asli women empowerment through tourism industry with anthropological perspective. The empowerment of Orang Asli women can be seen from the aspect of skills that they already have which can be turned into tourism products, as well as to increase their source of income in supplementing their family expenses. Among the skills that can be highlighted are making handicrafts, being tourist guides, promoting traditional cuisine and dances as well as finding and brewing wild plant roots for medicinal purposes. The women of the Orang Asli who originally only served as housewives, can now change their family’s way of life by doing all sorts of activities which can generate new sources of income, by venturing into activities that can be used as attractions and new tourism product markets, especially in Lenggong, Perak.

  9. Orange Recognition on Tree Using Image Processing Method Based on Lighting Density Pattern

    Directory of Open Access Journals (Sweden)

    H. R Ahmadi

    2015-03-01

    Full Text Available Within the last few years, a new tendency has been created towards robotic harvesting of oranges and some of citrus fruits. The first step in robotic harvesting is accurate recognition and positioning of fruits. Detection through image processing by color cameras and computer is currently the most common method. Obviously, a harvesting robot faces with natural conditions and, therefore, detection must be done in various light conditions and environments. In this study, it was attempted to provide a suitable algorithm for recognizing the orange fruits on tree. In order to evaluate the proposed algorithm, 500 images were taken in different conditions of canopy, lighting and the distance to the tree. The algorithm included sub-routines for optimization, segmentation, size filtering, separation of fruits based on lighting density method and coordinates determination. In this study, MLP neural network (with 3 hidden layers was used for segmentation that was found to be successful with an accuracy of 88.2% in correct detection. As there exist a high percentage of the clustered oranges in images, any algorithm aiming to detect oranges on the trees successfully should offer a solution to separate these oranges first. A new method based on the light and shade density method was applied and evaluated in this research. Finally, the accuracies for differentiation and recognition were obtained to be 89.5% and 88.2%, respectively.

  10. Calibrated photostimulated luminescence is an effective approach to identify irradiated orange during storage

    International Nuclear Information System (INIS)

    Jo, Yunhee; Sanyal, Bhaskar; Chung, Namhyeok; Lee, Hyun-Gyu; Park, Yunji; Park, Hae-Jun; Kwon, Joong-Ho

    2015-01-01

    Photostimulated luminescence (PSL) has been employed as a fast screening method for various irradiated foods. In this study the potential use of PSL was evaluated to identify oranges irradiated with gamma ray, electron beam and X-ray (0–2 kGy) and stored under different conditions for 6 weeks. The effects of light conditions (natural light, artificial light, and dark) and storage temperatures (4 and 20 °C) on PSL photon counts (PCs) during post-irradiation periods were studied. Non-irradiated samples always showed negative values of PCs, while irradiated oranges exhibited intermediate results after first PSL measurements. However, the irradiated samples had much higher PCs. The PCs of all the samples declined as the storage time increased. Calibrated second PSL measurements showed PSL ratio <10 for the irradiated samples after 3 weeks of irradiation confirming their irradiation status in all the storage conditions. Calibrated PSL and sample storage in dark at 4 °C were found out to be most suitable approaches to identify irradiated oranges during storage. - Highlights: • Photostimulatedluminescence (PSL) was studied to identify irradiated orange for quarantine application. • PSL detection efficiency was compared amonggamma,electron, and X irradiation during shelf-life of oranges • PSL properties of samples were characterized by standard samples • Calibrated PSL gave a clear verdict on irradiation extending potential of PSL technique

  11. Assessing the Effects of Climate Variability on Orange Yield in Florida to Reduce Production Forecast Errors

    Science.gov (United States)

    Concha Larrauri, P.

    2015-12-01

    Orange production in Florida has experienced a decline over the past decade. Hurricanes in 2004 and 2005 greatly affected production, almost to the same degree as strong freezes that occurred in the 1980's. The spread of the citrus greening disease after the hurricanes has also contributed to a reduction in orange production in Florida. The occurrence of hurricanes and diseases cannot easily be predicted but the additional effects of climate on orange yield can be studied and incorporated into existing production forecasts that are based on physical surveys, such as the October Citrus forecast issued every year by the USDA. Specific climate variables ocurring before and after the October forecast is issued can have impacts on flowering, orange drop rates, growth, and maturation, and can contribute to the forecast error. Here we present a methodology to incorporate local climate variables to predict the USDA's orange production forecast error, and we study the local effects of climate on yield in different counties in Florida. This information can aid farmers to gain an insight on what is to be expected during the orange production cycle, and can help supply chain managers to better plan their strategy.

  12. Allan Cox 1926”1987

    Science.gov (United States)

    Coe, Rob; Dalrymple, Brent

    More than 1000 friends, students, and colleagues from all over the country filled Stanford Memorial Chapel (Stanford, Calif.) on February 3, 1987, to join in “A Celebration of the Life of Allan Cox.” Allan died early on the morning of January 27 while bicycling, the sport he had come to love the most. Between pieces of his favorite music by Bach and Mozart, Stanford administrators and colleagues spoke in tribute of Allan's unique qualities as friend, scientist, teacher, and dean of the School of Earth Sciences. James Rosse, Vice President and Provost of Stanford University, struck a particularly resonant chord with his personal remarks: "Allan reached out to each person he knew with the warmth and attention that can only come from deep respect and affection for others. I never heard him speak ill of others, and I do not believe he was capable of doing anything that would harm another being. He cared too much to intrude where he was not wanted, but his curiosity about people and the loving care with which he approached them broke down reserve to create remarkable friendships. His enthusiasm and good humor made him a welcome guest in the hearts of the hundreds of students and colleagues who shared the opportunity of knowing Allan Cox as a person."

  13. Antioxidant activity of oils extracted from orange (Citrus sinensis seeds

    Directory of Open Access Journals (Sweden)

    Neuza Jorge

    2016-06-01

    Full Text Available Due to the increasing production of food in the world with consequent increase of the production of waste, the importance of developing researches for its use is noticed. Thus, the interest in vegetable oils with bioactive compounds, such as the ones extracted from fruit seeds, is growing. Therefore, the present study aims to characterize the oils extracted from seeds of Hamlin, Natal, Pera-rio and Valencia orange varieties (Citrus sinensis, as to the levels of total carotenoids, total phenolic compounds, tocopherols and phytosterols, as well as to determine their antioxidant activity. The orange seed oils presented important content of total carotenoids (19.01 mg/kg, total phenolic compounds (4.43 g/kg, α-tocopherol (135.65 mg/kg and phytosterols (1304.2 mg/kg. The antioxidant activity ranged from 56.0% (Natal to 70.2% (Pera-rio. According to the results it is possible to conclude that the orange seed oils can be used as specialty oils in diet, since they contain considerable amounts of bioactive compounds and antioxidants.

  14. Selskabsloven med kommentarer

    DEFF Research Database (Denmark)

    Schaumburg-Müller, Peer; Werlauff, Erik

    Selskabsloven med kommentarer er bibelen på området for kapitalselskaber. Den er et juridisk arbejdsredskab for praktikere, rådgivere, forskere og studerende. Bogen indeholder en komplet opdatering af kommentarerne i forhold til de mange ændringer i selskabsloven siden 1.-udgaven, men bygger i øv...

  15. 78 FR 729 - Ellman Battery Superfund Site; Orlando, Orange County, FL; Notice of Settlement

    Science.gov (United States)

    2013-01-04

    ... ENVIRONMENTAL PROTECTION AGENCY [FRL-9767-6; CERCLA-04-2012-3780] Ellman Battery Superfund Site; Orlando, Orange County, FL; Notice of Settlement AGENCY: Environmental Protection Agency (EPA). ACTION... Action at the Ellman Battery Superfund Site located in Orlando, Orange County, Florida. DATES: The Agency...

  16. Δ9-THC-caused synaptic and memory impairments are mediated through COX-2 signaling.

    Science.gov (United States)

    Chen, Rongqing; Zhang, Jian; Fan, Ni; Teng, Zhao-Qian; Wu, Yan; Yang, Hongwei; Tang, Ya-Ping; Sun, Hao; Song, Yunping; Chen, Chu

    2013-11-21

    Marijuana has been used for thousands of years as a treatment for medical conditions. However, untoward side effects limit its medical value. Here, we show that synaptic and cognitive impairments following repeated exposure to Δ(9)-tetrahydrocannabinol (Δ(9)-THC) are associated with the induction of cyclooxygenase-2 (COX-2), an inducible enzyme that converts arachidonic acid to prostanoids in the brain. COX-2 induction by Δ(9)-THC is mediated via CB1 receptor-coupled G protein βγ subunits. Pharmacological or genetic inhibition of COX-2 blocks downregulation and internalization of glutamate receptor subunits and alterations of the dendritic spine density of hippocampal neurons induced by repeated Δ(9)-THC exposures. Ablation of COX-2 also eliminates Δ(9)-THC-impaired hippocampal long-term synaptic plasticity, working, and fear memories. Importantly, the beneficial effects of decreasing β-amyloid plaques and neurodegeneration by Δ(9)-THC in Alzheimer's disease animals are retained in the presence of COX-2 inhibition. These results suggest that the applicability of medical marijuana would be broadened by concurrent inhibition of COX-2. Copyright © 2013 Elsevier Inc. All rights reserved.

  17. Complete degradation of Orange G by electrolysis in sub-critical water.

    Science.gov (United States)

    Yuksel, Asli; Sasaki, Mitsuru; Goto, Motonobu

    2011-06-15

    Complete degradation of azo dye Orange G was studied using a 500 mL continuous flow reactor made of SUS 316 stainless steel. In this system, a titanium reactor wall acted as a cathode and a titanium plate-type electrode was used as an anode in a subcritical reaction medium. This hydrothermal electrolysis process provides an environmentally friendly route that does not use any organic solvents or catalysts to remove organic pollutants from wastewater. Reactions were carried out from 30 to 90 min residence times at a pressure of 7 MPa, and at different temperatures of 180-250°C by applying various direct currents ranging from 0.5 to 1A. Removal of dye from the product solution and conversion of TOC increased with increasing current value. Moreover, the effect of salt addition on degradation of Orange G and TOC conversion was investigated, because in real textile wastewater, many salts are also included together with dye. Addition of Na(2)CO(3) resulted in a massive degradation of the dye itself and complete mineralization of TOC, while NaCl and Na(2)SO(4) obstructed the removal of Orange G. Greater than 99% of Orange G was successfully removed from the product solution with a 98% TOC conversion. Copyright © 2011 Elsevier B.V. All rights reserved.

  18. 76 FR 30197 - Orange Juice From Brazil; Notice of Commission Determination To Conduct a Full Five-Year Review...

    Science.gov (United States)

    2011-05-24

    ... INTERNATIONAL TRADE COMMISSION [Investigation No. 731-TA-1089 (Review)] Orange Juice From Brazil... Orderon Orange Juice From Brazil AGENCY: United States International Trade Commission. ACTION: Notice... antidumping duty orderon orange juice from Brazil would be likely to lead to continuation or recurrence of...

  19. Effect of uric acid on inflammatory COX-2 and ROS pathways in vascular smooth muscle cells.

    Science.gov (United States)

    Oğuz, Nurgül; Kırça, Mustafa; Çetin, Arzu; Yeşilkaya, Akın

    2017-10-01

    Hyperuricemia is thought to play a role in cardiovascular diseases (CVD), including hypertension, coronary artery disease and atherosclerosis. However, exactly how uric acid contributes to these pathologies is unknown. An underlying mechanism of inflammatory diseases, such as atherosclerosis, includes enhanced production of cyclooxygenase-2 (COX-2) and superoxide anion. Here, we aimed to examine the effect of uric acid on inflammatory COX-2 and superoxide anion production and to determine the role of losartan. Primarily cultured vascular smooth muscle cells (VSMCs) were time and dose-dependently induced by uric acid and COX-2 and superoxide anion levels were measured. COX-2 levels were determined by ELISA, and superoxide anion was measured by the superoxide dismutase (SOD)-inhibitable reduction of ferricytochrome c method. Uric acid elevated COX-2 levels in a time-dependent manner. Angiotensin-II receptor blocker, losartan, diminished uric-acid-induced COX-2 elevation. Uric acid also increased superoxide anion level in VSMCs. Uric acid plays an important role in CVD pathogenesis by inducing inflammatory COX-2 and ROS pathways. This is the first study demonstrating losartan's ability to reduce uric-acid-induced COX-2 elevation.

  20. Optical, magnetic and structural characterization of Zn1−xCoxO ...

    Indian Academy of Sciences (India)

    attracted considerable attention, both theoretically and experi- mentally, due to their ... C and finally ground to powder. Zn1−x Cox O ... Figure 1. Flowchart for solvothermal synthesis of Zn1−x Cox O (x = 0·038, 0·072 and 0·115) nanoparticles.

  1. Agent Orange and long-term outcomes after radical prostatectomy.

    Science.gov (United States)

    Ovadia, Aaron E; Terris, Martha K; Aronson, William J; Kane, Christopher J; Amling, Christopher L; Cooperberg, Matthew R; Freedland, Stephen J; Abern, Michael R

    2015-07-01

    To investigate the association between Agent Orange (AO) exposure and long-term prostate cancer (PC) outcomes. Data from 1,882 men undergoing radical prostatectomy for PC between 1988 and 2011 at Veterans Affairs Health Care Facilities were analyzed from the Shared Equal Access Regional Cancer Hospital database. Men were stratified by AO exposure (binary). Associations between AO exposure and biopsy and pathologic Gleason sum (GS) and pathologic stage were determined by logistic regression models adjusted for preoperative characteristics. Hazard ratios for biochemical recurrence (BCR), secondary treatment, metastases, and PC-specific mortality were determined by Cox models adjusted for preoperative characteristics. There were 333 (17.7%) men with AO exposure. AO-exposed men were younger (median 59 vs. 62 y), had lower preoperative prostate-specific antigen levels (5.8 vs. 6.7 ng/ml), lower clinical category (25% vs. 38% palpable), and higher body mass index (28.2 vs. 27.6 kg/m(2)), all P<0.01. Biopsy GS, pathologic GS, positive surgical margins, lymph node positivity, and extracapsular extension did not differ with AO exposure. At a median follow-up of 85 months, 702 (37.4%) patients had BCR, 603 (32.2%) patients received secondary treatment, 78 (4.1%) had metastases, and 39 (2.1%) died of PC. On multivariable analysis, AO exposure was not associated with BCR, secondary treatment, metastases, or PC mortality. AO exposure was not associated with worse preoperative characteristics such as elevated prostate-specific antigen levels or biopsy GS nor with BCR, secondary treatment, metastases, or PC death. Thus, as data on AO-exposed men mature, possible differences in PC outcomes observed previously are no longer apparent. Copyright © 2015 Elsevier Inc. All rights reserved.

  2. Simultaneous HPLC determination of flavonoids and phenolic acids profile in Pêra-Rio orange juice.

    Science.gov (United States)

    Mesquita, E; Monteiro, M

    2018-04-01

    The aim of this study was to develop and validate an HPLC-DAD method to evaluate the phenolic compounds profile of organic and conventional Pêra-Rio orange juice. The proposed method was validated for 10 flavonoids and 6 phenolic acids. A wide linear range (0.01-223.4μg·g -1 ), good accuracy (79.5-129.2%) and precision (CV≤3.8%), low limits of detection (1-22ng·g -1 ) and quantification (0.7-7.4μg), and overall ruggedness were attained. Good recovery was achieved for all phenolic compounds after extraction and cleanup. The method was applied to organic and conventional Pêra-Rio orange juices from beginning, middle and end of the 2016 harvest. Flavones rutin, nobiletin and tangeretin, and flavanones hesperidin, narirutin and eriocitrin were identified and quantified in all organic and conventional juices. Identity was confirmed by mass spectrometry. Nineteen non-identified phenolic compounds were quantified based on DAD spectra characteristic of the chemical class: 7 cinnamic acid derivatives, 6 flavanones and 6 flavones. The phenolic compounds profile of Pêra-Rio orange juices changed during the harvest; levels increased in organic orange juices, and decreased or were about the same in conventional orange juices. Phenolic compounds levels were higher in organic (0.5-1143.7mg·100g -1 ) than in conventional orange juices (0.5-689.7mg·100g -1 ). PCA differentiated organic from conventional FS and NFC juices, and conventional FCOJ from conventional FS and NFC juices, thus differentiating cultivation and processing. Copyright © 2017. Published by Elsevier Ltd.

  3. Integrated nutrient management for orange-fleshed sweet potato

    African Journals Online (AJOL)

    ACSS

    and variety, suggesting that the orange-fleshed sweet potato varieties responded similarly to nutrient ... fleshed ones, can help alleviate vitamin A deficiency .... LSD (0.05) for variety (V) mean. = 14.8 .... Information System, Working Paper #2.

  4. Minimizing the cancer-promotional activity of cox-2 as a central strategy in cancer prevention.

    Science.gov (United States)

    McCarty, Mark F

    2012-01-01

    A recent meta-analysis examining long-term mortality in subjects who participated in controlled studies evaluating the impact of daily aspirin on vascular risk, has concluded that aspirin confers substantial protection from cancer mortality. Remarkably, low-dose aspirin was as effective as higher-dose regimens; hence this protection may be achievable with minimal risk. There is reason to believe that this protection stems primarily from inhibition of cox-2 in pre-neoplastic lesions. Since safe aspirin regimens can only achieve a partial and transitory inhibition of cox-2, it may be feasible to complement the cancer-protective benefit of aspirin with other measures which decrease cox-2 expression or which limit the bioactivity of cox-2-derived PGE2. Oxidative stress boosts cox-2 expression by up-regulating activation of NF-kappaB and MAP kinases; NADPH oxidase activation may thus promote carcinogenesis by increasing cox-2 expression while also amplifying oxidant-mediated mutagenesis. A prospective cohort study has observed that relatively elevated serum bilirubin levels are associated with a marked reduction in subsequent cancer mortality; this may reflect bilirubin's physiological role as a potent inhibitor of NADPH oxidase. It may be feasible to mimic this protective effect by supplementing with spirulina, a rich source of a phycobilin which shares bilirubin's ability to inhibit NADPH oxidase. Ancillary antioxidant measures - phase 2 inducing phytochemicals, melatonin, N-acetylcysteine, and astaxanthin - may also aid cox-2 down-regulation. The cancer protection often associated with high-normal vitamin D status may be attributable, in part, to the ability of the activated vitamin D receptor to decrease cox-2 expression while promoting PGE2 catabolism and suppressing the expression of PGE2 receptors. Diets with a relatively low ratio of omega-6 to long-chain omega-3 fats may achieve cancer protection by antagonizing the production and bioactivity of PGE2. Growth

  5. Influence of anionic surfactant on the process of electro-Fenton decolorized methyl orange.

    Science.gov (United States)

    Ren, B X

    2010-01-01

    The electro-Fenton process has been shown to be very successful to remove dyes from water. However, the influence of other constituents in dyeing industry wastewater, such as Sodium Dodecyl Sulfate (SDS) surfactants, has not been investigated. In this study, the effect of SDS surfactant on the kinetics of Methyl Orange degradation undergoing Electro-Fenton process was investigated. Results show that Methyl Orange degradation rate decreased as SDS concentration (below Critical Micelle Concentration, CMC) increased, which was attributed to the consumption of hydroxyl radicals (( )OH) by surfactants. The kinetics modeling indicates the reaction was the first-order reaction to Methyl Orange even SDS existing. The pseudo first-order rate constants decreased as SDS concentration increased.

  6. Automation med pneumatiske servodrev - status og fremtid

    DEFF Research Database (Denmark)

    Sørensen, Paul Haase

    1996-01-01

    Der er råd for problemer med ulineariteter. Med de nyeste metoder kan der lineære driftsområde udvides. Men pneumatikkomponenter skal være af høj kvalitet, når positionering skal være nøjagtig....

  7. Opfattelser af integration blandt unge med migrantbaggrund

    DEFF Research Database (Denmark)

    Skytte, Marianne; Bryderup, Inge

    2014-01-01

    I artiklen formidles analyser af otte interview med unge med migrantbaggrund. Der er fokus på de unges oplevelser og opfattelser af integration. Der er tale om komplekse processer og vekselvirkninger i forholdet mellem de samfundsmæssige kategoriseringer og individernes selvopfattelser. De unge o...

  8. Isolation and biological activities of decanal, linalool, valencene, and octanal from sweet orange oil.

    Science.gov (United States)

    Liu, Kehai; Chen, Qiulin; Liu, Yanjun; Zhou, Xiaoyan; Wang, Xichang

    2012-11-01

    Product 1 (82.25% valencene), product 2 (73.36% decanal), product 3 (78.12% octanal), and product 4 (90.61% linalool) were isolated from sweet orange oil by combined usage of molecular distillation and column chromatography. The antioxidant activity of sweet orange oil and these products was investigated using 2,2-diphenyl-1-picrylhydrazyl and reducing power assays. In this test, product 1 (82.25% valencene), product 2 (73.36% decanal), and product 4 (90.61% linalool) had antioxidant activity, but lower than sweet orange oil. The antimicrobial activity was investigated in order to evaluate their efficacy against 5 microorganisms. The results showed that sweet orange oil, product 2 (73.36% decanal), product 3 (78.12% octanal), and product 4 (90.61% linalool) had inhibitory and bactericidal effect on the test microorganisms (except Penicillium citrinum). Valencene did not show any inhibitory effect. Saccharomyces cerivisiae was more susceptible, especially to the crude sweet orange oil (minimal inhibitory concentration 6.25 μL/mL). The cytotoxicity was evaluated on Hela cells using the 3-(4,5-dimethyl-thiazol-2-yl)-2,5-diphenyl tetrazolium bromide assay. All test samples showed significant cytotoxicity on the cell lines with IC(50) values much less than 20 μg/mL. © 2012 Institute of Food Technologists®

  9. Forandringslæring med autismediagnoser?

    DEFF Research Database (Denmark)

    Gustafson, Kari Ingrid; Mørck, Line Lerche

    2013-01-01

    Artiklen drøfter en række aktuelle spørgsmål omkring læring hos børn og unge med autisme-spektrum-forstyrrelses diagnoser. Der introduceres til en social praksisteoretisk forståelse af forandringslæring, der diskuterer forandring ikke kun i relation til en persons identitet, men også aktuelle og...... potentielle forandringer, når det gælder overskridelse af binær logik i autisme versus normalitet, samt i relation til at overskride individualiserede og dualistiske problem-forståelser af fejl og mangler ved det autistiske barn. Det illustreres, hvordan disse former for dualistisk tænkning er forankret i et...... Rasmus’ ændringer i læring, selvforståelse og tilhørsforhold perspektiveres med andre ASF-diagnostiseredes læring udforsket bl.a. gennem gruppeinterviews i regi af Asperger-foreningen. Artiklen byder således på et alternativ i form af at forstå forandringslæring som overskridende læring, med langt større...

  10. Effect of Fresh Orange Juice Intake on Physiological Characteristics in Healthy Volunteers

    OpenAIRE

    Asgary, Sedigheh; Keshvari, Mahtab; Afshani, Mohammad Reza; Amiri, Masoud; Laher, Ismail; Javanmard, Shaghayegh Haghjooy

    2014-01-01

    Background. Impaired endothelial function is a predictor of cardiovascular events. Orange juice (OJ) is rich in dietary flavonoids and could inhibit oxidative stress and inflammatory responses. We examined the effects of commercial (COJ) and fresh orange juice (FOJ) on endothelial function and physiological characteristics in healthy humans. Materials and Methods. Twenty-two healthy volunteers years were enrolled in a single blind randomized crossover controlled trial. The two groups consumed...

  11. INTERKALASI XILENOL ORANGE PADA ZEOLIT ALAM LAMPUNG SEBAGAI ELEKTRODA ZEOLIT TERMODIFIKASI

    Directory of Open Access Journals (Sweden)

    Fitriyah Fitriyah

    2016-07-01

    Full Text Available Zeolit terbagi menjadi zeolit alam dan zeolit sintesis, kapasitas adsorpsi zeolit alam umumnya lebih rendah daripada zeolit sintesis, sehingga untuk meningkatkan kapasitas adsorpsinya, karakter permukaan zeolit alam perlu diubah dengan melakukan proses modifikasi permukaan melalui berbagai metode, salah satunya dengan metode interkalasi. Tujuan penelitian ini yaitu menginterkalasi zat warna xilenol orange ke dalam zeolit alam Lampung dan mengaplikasikannya sebagai elektroda zeolit termodifikasi. Melalui proses interkalasi diharapkan dapat meningkatkan kegunaan dan nilai tambah dari zeolit. Data hasil penelitian menunjukkan bahwa xilenol orange (XO dapat diinterkalasikan ke dalam zeolit, hal ini dapat dilihat dari pita spektrum FTIR yang memiliki serapan pada bilangan gelombang 1383 cm-1, yaitu menunjukkan serapan dari S=O simetris dan asimetris pada gugus –SO3H,hal ini diduga karena XO memiliki gugus SO3 sehingga menyebabkan adanya serangan pada proton zeolit. Berdasarkan penelitian dapat disarikan bahwa xilanol orange dapat terinterkalasi pada zeolit alam Lampung dan dapat dimanfaatkan sebagai elektroda pendeteksi logam.

  12. Probe for intracellular concentrations of drugs: delayed fluorescence from acridine orange

    International Nuclear Information System (INIS)

    Wardman, P.; Dennis, M.F.; White, J.

    1989-01-01

    The aim of this work is to develop fluorescent probes that will indicate effective concentrations of therapeutic agents, or endogenous protectors, at important cellular sites. Acridine orange associates with nucleic acids and emits a 'delayed' fluorescence signal. This signal is quenched by oxidants such as oxygen, nitroaryl radiosensitizers, adriamycin and mitomycin-c, and reductants such as thiols, ascorbate and other radioprotectors. The quenching of the acridine orange delayed fluorescence reflects the effective concentration of these therapeutically-important oxidants and reductants near DNA. The relative concentration of basic radiosensitizers such as pimonidazole (Ro 03-8799) near the DNA is greater than that of misonidazole. Thiols quench the delayed fluorescence signal according to the degree of ionization of the thiol function; this may model the reactivity of thiols with guanine radical sites in DNA. Ascorbate and aminopyrine do not quench the delayed fluorescence from cells stained with acridine orange as these compounds are taken up by cells very inefficiently

  13. Perbandingan Inklinasi dan Ukuran Rahang antara Orang Jawa Buta dan Normal

    Directory of Open Access Journals (Sweden)

    C. Christnawati

    2016-10-01

    Full Text Available Latar Belakang. Penglihatan merupakan salah satu faktor yang diperlukan untuk mengontrol postur kepala. Postur kepala berhubungan dengan kompleks kraniofasial. Maksila dan mandibula merupakan bagian dari kompleks kraniofasial. Pada orang buta terjadi penyimpangan pertumbuhan dan perkembangan daerah orbita karena tidak adanya rangsang. Tujuan Penelitian adalah untuk mempelajari perbandingan inklinasi dan ukuran rahang berdasarkan jenis kelamin antara orang Jawa buta dan normal. Metode Penelitian. Penelitian ini dilakukan terhadap 53 subjek, terdiri dari 25 orang buta ( 12 orang laki-laki dan 13 orang perempuan dan 28 orang normal (14 orang laki-laki dan 14 orang perempuan. Setiap subjek penelitian dilakukan pengambilan sefalogram lateral pada posisi alamiah kepala, kemudian dilakukan penapakan pada kertas kalkir di atas iluminator. Pengukuran sembilan parameter inklinasi dan ukuran maksila dan mandibula dilakukan pada hasil penapakan. Data dianalisis dengan uji Anava dua jalur. Hasil penelitian menunjukkan bahwa terdapat perbedaan yang tidak bermakna (p<0,05. Panjang mandibula dan panjang basis mandibula laki-laki normal lebih besar daripada perempuan normal dan kelompok buta, serta perempuan normal lebih besar daripada perempuan buta (p<0,05. Kesimpulan Ukuran maksila laki-laki buta lebih besar daripada perempuan normal. Panjang mandibula dan panjang basis mandibula laki-laki normal lebih besar daripada perempuan normal lebih besar daripada perempuan normal, laki-laki buta, dan perempuan buta, serta perempuan normal lebih besar daripada perempuan buta.   Background Vision is one of the factors involved in the control of head posture. The posture of the head is related to craniofacial complex. Maxilla and mandible are part of craniofacial complex. In the blind there are deviations of growth and development of the orbital region in the absence of stimuli. The purpose of this study was to compare the inclinations and sizes of maxilla and mandible

  14. Long-term orange juice consumption is associated with low LDL-cholesterol and apolipoprotein B in normal and moderately hypercholesterolemic subjects

    Science.gov (United States)

    2013-01-01

    Background This study investigated the hypothesis that long-term orange juice consumption (≥ 12 months) was associated with low risk factors for cardiovascular disease in adult men and women with normal and moderately high cholesterol blood levels. Methods The sample consisted of 103 men (18–66 y) and 26 women (18–65 y); all were employees of an orange juice factory with daily access to free orange juice. The results showed that 41% of the individuals consumed 2 cups (480 mL) of orange juice per day for at least twelve months, while 59% of the volunteers are non-consumers of orange juice. Results Orange juice consumers with normal serum lipid levels had significantly lower total cholesterol (−11%, p juice consumers and non-consumers, but vitamin C and folate intake was higher in orange juice consumers. Conclusion Long-term orange juice consumers had lower levels of total cholesterol, LDL-cholesterol, apo B and LDL/HDL ratio and an improvement of folate and vitamin C in their diet. PMID:23919812

  15. Personer med handicap

    DEFF Research Database (Denmark)

    Larsen, Brian; Jonassen, Anders Bruun; Høgelund, Jan

    Regeringens Arbejdsmarkedskommission kommmer medio 2009 med forslag til, hvordan den samlede arbejdsindsats varigt kan øges gennem reformer på arbejdsmarkedet. En måde det kan ske på, er ved at begrænse antallet af personer, der står uden for arbejdsmarkedet som følge af helbredsproblemer. Rappor...

  16. Orange maize in Zambia: crop development and delivery experience

    African Journals Online (AJOL)

    Orange maize in Zambia: crop development and delivery experience. ... PROMOTING ACCESS TO AFRICAN RESEARCH. AFRICAN JOURNALS ONLINE ... African Journal of Food, Agriculture, Nutrition and Development. Journal Home ...

  17. Niacin and biosynthesis of PGD₂ by platelet COX-1 in mice and humans

    DEFF Research Database (Denmark)

    Song, Wen-Liang; Stubbe, Jane; Ricciotti, Emanuela

    2012-01-01

    during platelet activation in humans and, although vascular expression of DP1 is conserved between humans and mice, platelet DP1 is not present in mice. Despite this, DP1 deletion in mice augmented aneurysm formation and the hypertensive response to Ang II and accelerated atherogenesis and thrombogenesis....... Furthermore, COX inhibitors in humans, as well as platelet depletion, COX-1 knockdown, and COX-2 deletion in mice, revealed that niacin evoked platelet COX-1-derived PGD₂ biosynthesis. Finally, ADP-induced spreading on fibrinogen was augmented by niacin in washed human platelets, coincident with increased...... thromboxane (Tx) formation. However, in platelet-rich plasma, where formation of both Tx and PGD₂ was increased, spreading was not as pronounced and was inhibited by DP1 activation. Thus, PGD₂, like PGI₂, may function as a homeostatic response to thrombogenic and hypertensive stimuli and may have particular...

  18. Infection capacity of the pathogens Penicillium italicum and P. Expansum in orange during storage

    Directory of Open Access Journals (Sweden)

    Veljović Sonja P.

    2017-01-01

    Full Text Available Penicillium italicum and P. expansum are important pathogens causing decay in most fruits and vegetables. In this study, orange fruits were inoculated with these two species of fungus and stored 14 days with or without bagging, in a cold room for 11 days and 3 days at room temperature to determine the effect of bagging and infection capacities of both molds on oranges during storage. The results indicated that P. expansum can grow on orange peel with smaller colony diameter than P. italicum in bagged and unbagged fruits. Total soluble solids (TSS and firmness were not affected by bag. Gas composition of the bags showed low oxygen and high carbon dioxide concentration after fourteen days of storage. Bagged fruits decreased decay caused by P. italicum and weight loss, and delayed changes in firmness, TSS and acidity compared with control fruits. The study suggests that bagging may be a promising option for controlling decay, maintaining fruit quality and extending shelf-life of oranges.

  19. Stromal COX-2 signaling activated by deoxycholic acid mediates proliferation and invasiveness of colorectal epithelial cancer cells

    International Nuclear Information System (INIS)

    Zhu, Yingting; Zhu, Min; Lance, Peter

    2012-01-01

    Highlights: ► Human colonic cancer associated fibroblasts are major sources of COX-2 and PGE 2 . ► The fibroblasts interact with human colonic epithelial cancer cells. ► Activation of COX-2 signaling in the fibroblasts affects behavior of the epithelia. ► Protein Kinase C controls the activation of COX-2 signaling. -- Abstract: COX-2 is a major regulator implicated in colonic cancer. However, how COX-2 signaling affects colonic carcinogenesis at cellular level is not clear. In this article, we investigated whether activation of COX-2 signaling by deoxycholic acid (DCA) in primary human normal and cancer associated fibroblasts play a significant role in regulation of proliferation and invasiveness of colonic epithelial cancer cells. Our results demonstrated while COX-2 signaling can be activated by DCA in both normal and cancer associated fibroblasts, the level of activation of COX-2 signaling is significantly greater in cancer associated fibroblasts than that in normal fibroblasts. In addition, we discovered that the proliferative and invasive potential of colonic epithelial cancer cells were much greater when the cells were co-cultured with cancer associated fibroblasts pre-treated with DCA than with normal fibroblasts pre-treated with DCA. Moreover, COX-2 siRNA attenuated the proliferative and invasive effect of both normal and cancer associate fibroblasts pre-treated with DCA on the colonic cancer cells. Further studies indicated that the activation of COX-2 signaling by DCA is through protein kinase C signaling. We speculate that activation of COX-2 signaling especially in cancer associated fibroblasts promotes progression of colonic cancer.

  20. Gold Electrode Functionalized with Tridodecylamine for Impedimetric Detection of Acid Orange 10

    Directory of Open Access Journals (Sweden)

    Saida ZOUGAR

    2014-05-01

    Full Text Available In this work, we focus mainly characterize and develop a new type of impedimetric sensor for the detection of acid orange 10 (AO10: textile dye which is a toxic element in waters polluted by industrial waste. A siloprene based membrane was chosen, the used ionophore is the tridodecylamine (TDA. The results are interesting because the developed sensor gives a linear response range of concentrations 10-13 M - 10-3 M for acid orange 10 in aqueous medium with a good correlation coefficient of 0.9862 and a low detection limit of 10-13 M, indicating the sensitivity of the sensor overlooked the target element. Ion sensitivity of sensor has been tested for acid orange 10 via methyl blue (MB. A layer of tridodecylamine deposited on gold electrode has been characterized by impedance spectroscopy and cyclic voltammetry methods.

  1. 76 FR 35886 - Orange Cove Irrigation District, and Friant Power Authority; Notice of Availability of...

    Science.gov (United States)

    2011-06-20

    ... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Project No. 11068-014--California] Orange Cove Irrigation District, and Friant Power Authority; Notice of Availability of Environmental... has prepared an Environmental Assessment (EA) regarding Orange Cove Irrigation District's and Friant...

  2. Fresh and Commercially Pasteurized Orange Juice: An Analysis of the Metabolism of Flavonoid Compounds

    Science.gov (United States)

    Orange juice is a rich source of flavonoids, mainly the flavanones hesperidin and narirutin, associated with health benefits in humans. The objective of this study was to analyze the uptake of flavonoids in humans after the consumption of two types of orange juice, fresh squeezed (fresh juice, FJ) a...

  3. 稀脉萍对水中甲基橙的毒害响应及去除研究%Study on Toxic Response of Lemna Aequinoctialis to Methyl Orange and Removal of Methyl Orange

    Institute of Scientific and Technical Information of China (English)

    陈秋平; 胥思勤

    2014-01-01

    Methyl orange was used as an environmental stress factor to examine the effects on enzyme activity of peroxidase,content of soluble protein,and chlorophyll content of Lemna aequinoctialis leaves.L.aequinoctialis was applied to removal Methyl orange.The results showed that enzyme activity of peroxidase rised first and then fell with the increase of Methyl orange concentration.When Methyl orange concentration was 1 40 mg/L,enzyme activi-ty of peroxidase came to the maximum.When Methyl orange concentration was more than 1 00 mg/L,soluble pro-tein content dropped rapidly.The chlorophyll content and the ratio of chlorophyll a to chlorophyll b decreased with the increase of Methyl orange concentration.When Methyl orange concentration was 20 mg/L,there was a 1 0 -day lag period.Then the degradation rate of Methyl orange could reach 89.6 %after L.aequinoctialis was cultured 24 days.%用甲基橙作为胁迫因子,研究了甲基橙对稀脉萍叶片过氧化物酶活性、可溶性蛋白含量和叶绿素含量的影响,并采用稀脉萍去除甲基橙。结果表明:随着甲基橙浓度的增加,过氧化物酶活性呈先上升后下降的趋势,当甲基橙浓度为140mg/L时,过氧化物酶活性达到最高值。当甲基橙浓度>100mg/L,可溶性蛋白含量急速下降。叶绿素含量和叶绿素a/b比值均随甲基橙浓度的升高而降低。当甲基橙浓度为20 mg/L时,稀脉萍对甲基橙的去除需经10 d的延滞期,24 d后去除率达89.6%。

  4. Niacin and biosynthesis of PGD2 by platelet COX-1 in mice and humans

    Science.gov (United States)

    Song, Wen-Liang; Stubbe, Jane; Ricciotti, Emanuela; Alamuddin, Naji; Ibrahim, Salam; Crichton, Irene; Prempeh, Maxwell; Lawson, John A.; Wilensky, Robert L.; Rasmussen, Lars Melholt; Puré, Ellen; FitzGerald, Garret A.

    2012-01-01

    The clinical use of niacin to treat dyslipidemic conditions is limited by noxious side effects, most commonly facial flushing. In mice, niacin-induced flushing results from COX-1–dependent formation of PGD2 and PGE2 followed by COX-2–dependent production of PGE2. Consistent with this, niacin-induced flushing in humans is attenuated when niacin is combined with an antagonist of the PGD2 receptor DP1. NSAID-mediated suppression of COX-2–derived PGI2 has negative cardiovascular consequences, yet little is known about the cardiovascular biology of PGD2. Here, we show that PGD2 biosynthesis is augmented during platelet activation in humans and, although vascular expression of DP1 is conserved between humans and mice, platelet DP1 is not present in mice. Despite this, DP1 deletion in mice augmented aneurysm formation and the hypertensive response to Ang II and accelerated atherogenesis and thrombogenesis. Furthermore, COX inhibitors in humans, as well as platelet depletion, COX-1 knockdown, and COX-2 deletion in mice, revealed that niacin evoked platelet COX-1–derived PGD2 biosynthesis. Finally, ADP-induced spreading on fibrinogen was augmented by niacin in washed human platelets, coincident with increased thromboxane (Tx) formation. However, in platelet-rich plasma, where formation of both Tx and PGD2 was increased, spreading was not as pronounced and was inhibited by DP1 activation. Thus, PGD2, like PGI2, may function as a homeostatic response to thrombogenic and hypertensive stimuli and may have particular relevance as a constraint on platelets during niacin therapy. PMID:22406532

  5. 75 FR 62455 - Importation of Fresh Unshu Oranges From the Republic of Korea Into the Continental United States

    Science.gov (United States)

    2010-10-12

    ... of Elsinoe australis, the fungus that is the causal agent of sweet orange scab. (In addition to...-0022] RIN 0579-AD14 Importation of Fresh Unshu Oranges From the Republic of Korea Into the Continental... on the importation of Unshu oranges from the Republic of Korea that are no longer necessary...

  6. Juridiske overvejelser i forbindelse med Influence Operationer

    DEFF Research Database (Denmark)

    Nissen, Thomas Elkjer

    2014-01-01

    Kapitel 8: Juridiske overvejelser i forbindelse med influence-operationer Af Thomas Elkjer Nissen Dette kapitel fokuserer ligesom kapitel 9 på de juridiske problemstillinger, som den teknologiske udvikling har bragt med sig til væbnede konflikter; i dette kapitel er der fokus på kommunikation....... Kapitlet ser nærmere på det moderne informationsmiljø, dets betydning i moderne konflikter og den stigende anvendelse af information som magtmiddel. Herefter rettes blikket mod de juridiske overvejelser, der er forbundet med influence-operationer, bl.a. tid og rum, chefansvar, mandat og juridisk grundlag....... Afsnittet behandler desuden bl.a. jus in bello’s grundlæggende princippers indflydelse på influence-operationer....

  7. Ukraine i fokus sammen med Georgien

    DEFF Research Database (Denmark)

    Fledelius, Karsten

    2017-01-01

    Der er god grund til at sammenligne Ukraine og Georgien, nu fokuslande for Danmark, og der er god grund til at støtte disse to eks-sovjetiske stater med i høj grad parallelle problemer.......Der er god grund til at sammenligne Ukraine og Georgien, nu fokuslande for Danmark, og der er god grund til at støtte disse to eks-sovjetiske stater med i høj grad parallelle problemer....

  8. [Specific inhibitors of cyclooxygenase-2 (COX-2): current knowledge and perspectives].

    Science.gov (United States)

    Rioda, W T; Nervetti, A

    2001-01-01

    The Authors summarize the current knowledge on a new class of nonsteroidal anti-inflammatory drugs (NSAIDs), the coxib (celecoxib and rofecoxib), in the treatment of rheumatic diseases. Celecoxib and rofecoxib are selective cyclooxygenase-2 (COX-2) inhibitors which possess the same anti-inflammatory and analgesic activities, but a better gastric tolerability compared to the non-selective COX-1 and COX-2 inhibitors. The Authors also report other possible therapeutic effects of these NSADIs as evidenced by the more recent data of the literature. Celecoxib seems to reduce the incidence of new polyps in patients with familial adenomatous polyposis. It has been suggested the use of celecoxib as a protective drug against the development of colorectal cancer. Other (neoplastic) or pre-neoplastic conditions, such as bladder dysplasia, Barret esophagus, attinic keratosis and Alzheimer's disease seem to have benefit from this class of drugs.

  9. Health benefits of orange juice and citrus flavonoids

    Science.gov (United States)

    The main flavonoids found in orange juice are hesperidin and naringenin, which can affect several metabolic routes that improve blood serum antioxidant capacity and anti-inflammatory performance, while decreasing insulin resistance protecting against diabetes and metabolic syndrome. In addition, or...

  10. Approved Drug Products with Therapuetic Equivalence Evaluations (Orange Book)

    Data.gov (United States)

    U.S. Department of Health & Human Services — The publication Approved Drug Products with Therapeutic Equivalence Evaluations (the List, commonly known as the Orange Book) identifies drug products approved on...

  11. Using Eggshell in Acid Orange 2 Dye Removal from Aqueous Solution

    Directory of Open Access Journals (Sweden)

    Ahmad Reza Yari

    2015-05-01

    Full Text Available Background and purpose: Generated dye wastewater by the textile industry is usually toxic, non-biodegradable and resistant in the environment. Eggshell is one of the inexpensive material and for the reason the vesicular structures can be used as a proper adsorbent for pollutants removal. The aim of this study is to investigate the efficiency of eggshell for removal of acid orange 2 dye from aqueous solution. Materials and Methods: In the experimental study was determined the efficacy of variant variables such as contact time (15, 30, 60, 90 and 120 min, pH (3, 7 and 11, adsorbent dose (10, 25, 50 and 75 g/L, and initial dye concentration (25, 50 and 100 mg/L. The concentration of dye by spectrophotometer ultraviolet/visible in the wavelength 483 nm was examined. Results: The results showed that with increasing contact time and adsorbent dose, the dye removal efficiency was increased, but with increasing pH and initial dye concentration the removal efficiency was decreased. The maximum of removal efficiency of acid orange 2 dye got in the optimum pH: 3, contact time: 90 min, adsorbent dose: 50 g/L and initial dye concentration: 25 mg/L. Adsorption of acid orange 2 dye (R2 = 0.87 follow the Freundlich isotherm. Conclusion: Eggshells can be used as an inexpensive and effective adsorbent for the removal of acid orange 2 dye.

  12. Extraction of essential oil from baby Java orange (Citrus sinensis) solid waste using water and steam distillation

    Science.gov (United States)

    Dewi, I. A.; Prastyo, A. M.; Wijana, S.

    2018-03-01

    Baby java orange (Citrus sinensis) is commonly consumed as juice. Processing of baby java orange leaves organic waste which consist of the mesocarp, exocarp, seed, and wall of the orange. Therefore, it is necessary to process baby java orange waste to be valuable products. The purpose of this study was to provide added value to unutilized baby java orange waste, and to find out the pretreatment of time-delay process that maximize the yield of essential oil produced. Essential oil processing can be done by water and steam distillation. The study used randomized block design with one factor namely distillation time-delay process by air drying consisted of 4 levels i.e. the distillation delay for 2, 4, 6, and 8 days. The best treatment was determined based on the yield. The best essential oil from baby java orange waste was obtained from the treatment of distillation delay-process of 8 days. This pretreatment generated yield value of 0.63% with moisture content of 24.21%. By estimating the price of essential oil showed that this effort not only reduced the bulky organic waste but also provided potential economical value.

  13. Complex layering of the Orange Mountain Basalt: New Jersey, USA

    Science.gov (United States)

    Puffer, John H.; Block, Karin A.; Steiner, Jeffrey C.; Laskowich, Chris

    2018-06-01

    The Orange Mountain Basalt of New Jersey is a Mesozoic formation consisting of three units: a single lower inflated sheet lobe about 70 m thick (OMB1), a middle pillow basalt about 10 to 20 m thick (OMB2), and an upper compound pahoehoe flow about 20 to 40 m thick (OMB3). The Orange Mountain Basalt is part of the Central Atlantic Magmatic Province. Quarry and road-cut exposures of OMB1 near Paterson, New Jersey, display some unusual layering that is the focus of this study. OMB1 exposures displays the typical upper crust, core, and basal crust layers of sheet lobes but throughout the Patterson area also display distinct light gray layers of microvesicular basalt mineralized with albite directly over the basal crust and under the upper crust. The lower microvesicular layer is associated with mega-vesicular diapirs. We propose that the upper and lower microvesicular layers were composed of viscous crust that was suddenly quenched before it could devolatilize immediately before the solidification of the core. During initial cooling, the bottom of the basal layer was mineralized with high concentrations of calcite and albite during a high-temperature hydrothermal event. Subsequent albitization, as well as zeolite, prehnite, and calcite precipitation events, occurred during burial and circulation of basin brine heated by recurring Palisades magmatism below the Orange Mountain Basalt. Some of the events experienced by the Orange Mountain Basalt are unusual and place constraints on the fluid dynamics of thick flood basalt flows in general. The late penetration of vesicular diapirs through the entire thickness of the flow interior constrains its viscosity and solidification history.

  14. Improved photocatalytic degradation of Orange G using hybrid nanofibers

    Energy Technology Data Exchange (ETDEWEB)

    Ledwaba, Mpho; Masilela, Nkosiphile; Nyokong, Tebello; Antunes, Edith, E-mail: ebeukes@uwc.ac.za [Rhodes University, Department of Chemistry (South Africa)

    2017-05-15

    Functionalised electrospun polyamide-6 (PA-6) nanofibres incorporating gadolinium oxide nanoparticles conjugated to zinc tetracarboxyphenoxy phthalocyanine (ZnTCPPc) as the sensitizer were prepared for the photocatalytic degradation of Orange G. Fibres incorporating the phthalocyanine alone or a mixture of the nanoparticles and phthalocyanine were also generated. The singlet oxygen-generating ability of the sensitizer was shown to be maintained within the fibre mat, with the singlet oxygen quantum yields increasing upon incorporation of the magnetic nanoparticles. Consequently, the rate of the photodegradation of Orange G was observed to increase with an increase in singlet oxygen quantum yield. A reduction in the half-lives for the functionalised nanofibres was recorded in the presence of the magnetic nanoparticles, indicating an improvement in the efficiency of the degradation process.

  15. Compensation for Orang AsH native land in Malaysia: The perceptions and challenges in its quantification

    OpenAIRE

    Anuar Alias; Md Nasir Daud

    2008-01-01

    This paper describes the results of an investigation on the challenges confronting valuers in dealing with the assessment of compensation for Orang Asli native land (OANL). In Malaysia, valuers are often ambivalent about assessing the worth of Orang Asli property rights; this is because the conventional valuation toolkits are 'ill-equipped' to cope with the multi-faceted issues involved in valuing such lands. Orang Asli view the worth of their lands from a multitude of dimensions (spiritual, ...

  16. Stromal COX-2 signaling activated by deoxycholic acid mediates proliferation and invasiveness of colorectal epithelial cancer cells

    Energy Technology Data Exchange (ETDEWEB)

    Zhu, Yingting, E-mail: yitizhu@yahoo.com [Arizona Cancer Center, The University of Arizona, Tucson, AZ 85724 (United States); Tissue Tech Inc., Miami, FL 33173 (United States); Zhu, Min; Lance, Peter [Arizona Cancer Center, The University of Arizona, Tucson, AZ 85724 (United States)

    2012-08-31

    Highlights: Black-Right-Pointing-Pointer Human colonic cancer associated fibroblasts are major sources of COX-2 and PGE{sub 2}. Black-Right-Pointing-Pointer The fibroblasts interact with human colonic epithelial cancer cells. Black-Right-Pointing-Pointer Activation of COX-2 signaling in the fibroblasts affects behavior of the epithelia. Black-Right-Pointing-Pointer Protein Kinase C controls the activation of COX-2 signaling. -- Abstract: COX-2 is a major regulator implicated in colonic cancer. However, how COX-2 signaling affects colonic carcinogenesis at cellular level is not clear. In this article, we investigated whether activation of COX-2 signaling by deoxycholic acid (DCA) in primary human normal and cancer associated fibroblasts play a significant role in regulation of proliferation and invasiveness of colonic epithelial cancer cells. Our results demonstrated while COX-2 signaling can be activated by DCA in both normal and cancer associated fibroblasts, the level of activation of COX-2 signaling is significantly greater in cancer associated fibroblasts than that in normal fibroblasts. In addition, we discovered that the proliferative and invasive potential of colonic epithelial cancer cells were much greater when the cells were co-cultured with cancer associated fibroblasts pre-treated with DCA than with normal fibroblasts pre-treated with DCA. Moreover, COX-2 siRNA attenuated the proliferative and invasive effect of both normal and cancer associate fibroblasts pre-treated with DCA on the colonic cancer cells. Further studies indicated that the activation of COX-2 signaling by DCA is through protein kinase C signaling. We speculate that activation of COX-2 signaling especially in cancer associated fibroblasts promotes progression of colonic cancer.

  17. COX-2 Inhibitors for Cancer Treatment in Dogs

    Directory of Open Access Journals (Sweden)

    Andrigo Barboza De Nardi*, Talita Mariana Morata Raposo1, Rafael Ricardo Huppes1, Carlos Roberto Daleck2 and Renée Laufer Amorim3

    2011-10-01

    Full Text Available Cancer is one of the main causes of death in canines and felines, and this fact is probably related to the increase in the longevity of these species. The longer the animals live, the higher the exposure to carcinogenic agents will be. With the high incidence of cancer in companion animals, new studies are currently being performed with the aim of finding therapeutic options which make the complete inhibition of the development of neoplasms in animals possible in the future. The correlation of cyclooxygenase-2 (COX-2 whith the development of cancer opens the way for the use of new therapeutic approaches. This relationship has been suggested based on various studies which established an association between the chronic use of nonsteroidal anti-inflammatory drugs (NSAID and a decrease in the incidence of colon carcinoma. As cancer progresses, COX-2 participates in the arachidonic acid metabolism by synthesizing prostaglandins which can mediate various mechanisms related to cancer development such as: increase in angiogenesis, inhibition of apoptosis, suppression of the immune response, acquisition of greater invasion capacity and metastasis. Accordingly, overexpression of this enzyme in tumors has been associated with the most aggressive, poor-prognosis cancer types, especially carcinomas. Therefore, treatments which use COX-2 inhibitors such as coxibs, whether administered as single agents or in combination with conventional antineoplastic chemotherapy, are an alternative for extending the survival of our cancer patients.

  18. Molecular cloning, characterization and functional analysis of QRFP in orange-spotted grouper (Epinephelus coioides).

    Science.gov (United States)

    Shu, Hu; Chen, Huapu; Liu, Yun; Yang, Lidong; Yang, Yuqing; Zhang, Haifa

    2014-10-01

    The peptide QRFP plays an important role in the regulation of vertebrate feeding behavior. In this study, we cloned the full length cDNA of a QRFP precursor in a teleost fish, the orange-spotted grouper (Epinephelus coioides). Sequence analysis has shown that the functional regions of QRFP in other vertebrates (QRFP-25 and QRFP-7) are conserved in orange-spotted grouper. RT-PCR demonstrated that the pre-processed mRNA of QRFP is widely expressed in orange-spotted grouper. Three days of food deprivation did not change the hypothalamic pre-processed QRFP expression. However, QRFP expression significantly increased when the fish were reefed after three days of fasting. Intraperitoneal injection of QRFP-25 peptide to orange-spotted grouper suppressed expression of orexin, but elevated expression of pro-opiomelanocortin (POMC) in the hypothalamus. We also investigated the effects of QRFP-25 on the expression of reproductive genes. The peptide suppressed the expression of seabream-type gonadotropin-releasing hormones (sbGnRH), luteinizing hormone beta subunit (LHβ) and follicle-stimulating hormone beta subunit (FSHβ) in vivo, as well as inhibited the expression of LHβ and FSHβ in pituitary cells in primary culture. Our results indicate that QRFP may play an inhibitory role in the regulation of feeding behavior and reproduction in orange-spotted grouper. Copyright © 2014 Elsevier Inc. All rights reserved.

  19. Use of Banana (Musa acuminata Colla AAA) Peel Extract as an Antioxidant Source in Orange Juices.

    Science.gov (United States)

    Ortiz, Lucía; Dorta, Eva; Gloria Lobo, M; González-Mendoza, L Antonio; Díaz, Carlos; González, Mónica

    2017-03-01

    Using banana peel extract as an antioxidant in freshly squeezed orange juices and juices from concentrate was evaluated. Free radical scavenging capacity increased by adding banana peel extracts to both types of orange juice. In addition, remarkable increases in antioxidant capacity using 2,2'-azino-bis-(3-ethylbenzothiazoline)-6-sulfonic acid (ABTS) radical were observed when equal or greater than 5 mg of banana peel extract per ml of freshly squeezed juice was added. No clear effects were observed in the capacity to inhibit lipid peroxidation. Adding 5 mg banana peel extract per ml of orange juice did not substantially modify the physicochemical and sensory characteristics of either type of juice. However, undesirable changes in the sensory characteristics (in-mouth sensations and colour) were detected when equal or greater than 10 mg banana peel extract per ml of orange juice was added. These results confirm that banana peel is a promising natural additive that increases the capacity to scavenge free radicals of orange juice with acceptable sensory and physicochemical characteristics for the consumer.

  20. A Box-Cox normal model for response times.

    Science.gov (United States)

    Klein Entink, R H; van der Linden, W J; Fox, J-P

    2009-11-01

    The log-transform has been a convenient choice in response time modelling on test items. However, motivated by a dataset of the Medical College Admission Test where the lognormal model violated the normality assumption, the possibilities of the broader class of Box-Cox transformations for response time modelling are investigated. After an introduction and an outline of a broader framework for analysing responses and response times simultaneously, the performance of a Box-Cox normal model for describing response times is investigated using simulation studies and a real data example. A transformation-invariant implementation of the deviance information criterium (DIC) is developed that allows for comparing model fit between models with different transformation parameters. Showing an enhanced description of the shape of the response time distributions, its application in an educational measurement context is discussed at length.

  1. A new approach to the Box-Cox transformation

    Directory of Open Access Journals (Sweden)

    Jorge Iván eVélez

    2015-10-01

    Full Text Available We propose a new methodology to estimate λ, the parameter of the Box-Cox transformation, as well as an alternative method to determine plausible values for it. The former is accomplished by defining a grid of values for λ and further perform a normality test on the λ -transformed data. The optimum value of λ, say λ * , is such that the p-value from the normality test is the highest. The set of plausible values is determined using the inverse probability method after plotting the p-values against the values of λ on the grid. Our methodology is illustrated with two real-world data sets. Furthermore, a simulation study suggests that our method improves the symmetry, kurtosis and, hence, the normality of data, making it a feasible alternative to the traditional Box-Cox transformation.

  2. Drinking orange juice increases total antioxidant status and decreases lipid peroxidation in adults.

    Science.gov (United States)

    Foroudi, Shahrzad; Potter, Andrew S; Stamatikos, Alexis; Patil, Bhimanagouda S; Deyhim, Farzad

    2014-05-01

    Cardiovascular disease (CVD) is the leading cause of death in the world and is the primary cause of mortality among Americans. One of the many reasons for the pathogenesis of CVD is attributed to eating diets high in saturated fat and refined carbohydrates and low in fruits and vegetables. Epidemiological evidence has supported a strong association between eating diets rich in fruits and vegetables and cardiovascular health. An experiment was conducted utilizing 24 adults with hypercholesterolemia and hypertriglyceridemia to evaluate the impact of drinking 20 fl oz of freshly squeezed orange juice daily for 90 days on blood pressure, lipid panels, plasma antioxidant capacity, metabolic hormones, lipid peroxidation, and inflammatory markers. Except for addition of drinking orange juice, subjects did not modify their eating habits. The findings suggested that drinking orange juice does not affect (P>.1) blood pressure, lipid panels, metabolic hormones, body fat percentage, or inflammatory markers. However, total plasma antioxidant capacity was significantly increased (Pjuice consumption. Drinking orange juice may protect the cardiovascular system by increasing total plasma antioxidant status and by lowering lipid peroxidation independent of other cardiovascular risk markers evaluated in this study.

  3. Emotion-Aware Assistive System for Humanistic Care Based on the Orange Computing Concept

    Directory of Open Access Journals (Sweden)

    Jhing-Fa Wang

    2012-01-01

    Full Text Available Mental care has become crucial with the rapid growth of economy and technology. However, recent movements, such as green technologies, place more emphasis on environmental issues than on mental care. Therefore, this study presents an emerging technology called orange computing for mental care applications. Orange computing refers to health, happiness, and physiopsychological care computing, which focuses on designing algorithms and systems for enhancing body and mind balance. The representative color of orange computing originates from a harmonic fusion of passion, love, happiness, and warmth. A case study on a human-machine interactive and assistive system for emotion care was conducted in this study to demonstrate the concept of orange computing. The system can detect emotional states of users by analyzing their facial expressions, emotional speech, and laughter in a ubiquitous environment. In addition, the system can provide corresponding feedback to users according to the results. Experimental results show that the system can achieve an accurate audiovisual recognition rate of 81.8% on average, thereby demonstrating the feasibility of the system. Compared with traditional questionnaire-based approaches, the proposed system can offer real-time analysis of emotional status more efficiently.

  4. Chemical and sensory characterization of orange (Citrus sinensis) pulp,a by-product of orange juice processing using gas-chromatography-olfactometry

    Science.gov (United States)

    Volatile composition of commercial orange pulp (from Brazil and Florida, U.S.A.) were analyzed by gas chromatography-mass spectrometry (GC-MS) and GC-Olfactometry (GC-O). In both samples 72 volatiles were detected, of which 58 were identified. Odor-active compounds with high frequency of detection (...

  5. A review of orange roughy Hoplostethus atlanticus fisheries ...

    African Journals Online (AJOL)

    ... catch rate until a survey series has been established. Keywords: age determination, aggregations, assessment, biology, diet, distribution, fisheries, genetics, habitat, Hoplostethus atlanticus, lipids, Namibia, orange roughy, reproduction, review, stock structure, surveys. African Journal of Marine Science 2001, 23: 181–203 ...

  6. Life cycle assessment of orange peel waste management

    DEFF Research Database (Denmark)

    Negro, Viviana; Ruggeri, Bernardo; Fino, Debora

    2017-01-01

    on-land digestate use. Orange peel waste use for animal feeding, while appearing interesting from an environmental perspective (for example to reduce meal imports), presents practical challenges as far as the nutritional aspects and costs are concerned, and these eventually hinder its market...

  7. Effektivisering av arbetet med rumsbeskrivningar

    OpenAIRE

    Enström, Magnus

    2016-01-01

    För att ta byggbranschen till nästa steg i utvecklingen är BIM det naturliga steget. Iteorin tycks många av lösningarna som medföljer implementationen av BIM varaenkla att förstå och skapa, i praktiken ligger dock de tekniska lösningarna långt ifrånen full implementation i branschen. I arbetet med olika typer av beskrivningar inomett byggprojekt har utvecklingen med hjälp av BIM stått still länge. Då det inte finnsnågot vedertaget sätt att utnyttja en BIM-modells information för att fylla oli...

  8. Fang CO2 med Aminosyrer

    DEFF Research Database (Denmark)

    Lerche, Benedicte Mai

    2010-01-01

    Med såkaldte “carbon capture-teknikker” er det muligt at rense røgen fra kulfyrede kraftværker, således at den er næsten helt fri for drivhusgassen CO2. Kunsten er at gøre processen tilstrækkeligt billig. Et lovende fangstredskab i denne proces er aminosyrer.......Med såkaldte “carbon capture-teknikker” er det muligt at rense røgen fra kulfyrede kraftværker, således at den er næsten helt fri for drivhusgassen CO2. Kunsten er at gøre processen tilstrækkeligt billig. Et lovende fangstredskab i denne proces er aminosyrer....

  9. Decolorization of Orange Ⅱ using an anaerobic sequencing batch reactor with and without co-substrates

    Institute of Scientific and Technical Information of China (English)

    Soon-An Ong; Eiichi Toorisaka; Makoto Hirata; Tadashi Hano

    2012-01-01

    We investigated the decolorization of Orange Ⅱ with and without the addition of co-substrates and nutrients under an anaerobic sequencing batch reactor (ASBR).The increase in COD concentrations from 900 to 1750 to 3730 mg/L in the system treating 100 mg/L of Orange H-containing wastewater enhanced color removal from 27% to 81% to 89%,respectively.In the absence of co-substrates and nutrients,more than 95% of decolorization was achieved by the acclimatized anaerobic microbes in the bioreactor treating 600 mg/L of Orange Ⅱ.The decrease in mixed liquor suspended solids concentration by endogenous lysis of biomass preserved a high reducing environment in the ASBR,which was important for the reduction of the Orange Ⅱ azo bond that caused decolorization.The maximum decolorization rate in the ASBR was approximately 0.17 g/hr in the absence of co-substrates and nutrients.

  10. Mindfulness som smertehåndteringsredskab for kvinder med endometriose

    DEFF Research Database (Denmark)

    Jensen, Mette Kold; Vedsted-Hansen, Hanne; Hansen, Tia G. B.

    2011-01-01

    Endometriose er en kronisk underlivssygdom med smerter og en række afledte problemer, som ikke nødvendigvis kan behandles med lægelige tiltag. Artiklen argumenterer for, at en mindfulness-baseret tilgang med fokus på smertehåndtering kan anvendes til denne klientgruppe. I vestlig terapeutisk...... sammenhæng kan mindfulness karakteriseres som nærvær, observation og beskrivelse af sansninger uden vurdering eller reaktion. Mindfulness-træning har effekt mod andre typer stress og kroniske smerter, og artiklen opridser et koncept til anvendelse ved endometriose. Konceptet belyses med en case, hvor...

  11. KONSTRUKSI KOMUNIKASI ORANG TUA DALAM PENDIDIKAN MEDIA PADA ANAK USIA DINI DI KEC. KATAPANG KABUPATEN BANDUNG

    Directory of Open Access Journals (Sweden)

    Heru Ryanto Budiana

    2017-08-01

    Full Text Available Abstrak. Dewasa ini anak-anak dapat menonton berbagai tayangan di televisi padahal isi televisitidak selamanya baik untuk masyarakat terutama anak-anak. Berbagai muatan kekerasan,hedonisme, konsumerisme, mistik, pornografi dan budaya instan hadir dalam setiap keluargamelalui televisi. Hal ini membuktikan bahwa televisi memiliki dua wajah: wajah baik dan wajahburuk. Sementara banyak orang tua tidak memiliki cukup waktu untuk menjaga anak-anaknyadari terpaan wajah buruk media. Anak belum memiliki kemampuan filtrasi aktif, oleh karena ituorang dewasa dalam hal ini orang tua dituntut untuk memberikan pendidikan media pada anak.Idealnya pendidikan media diberikan di jenjang usia dini. Sejak pertama kali anak dapatberinteraksi dengan media. Namun untuk melakukan pendidikan media pada anak usia dinibukanlah hal yang mudah karena orang tua harus mengetahui terlebih dahulu bagaimana prinsippembelajaran untuk anak usia dini, mengingat anak usia dini adalah pembelajar yang aktif.Orang tua perlu melakukan pendampingan atau parental mediation merujuk pada upayamemodifikasi atau bahkan mencegah efek yang berhubungan dengan interaksi anak dan televisi.Abstrak. Dewasa ini anak-anak dapat menonton berbagai tayangan di televisi padahal isi televisitidak selamanya baik untuk masyarakat terutama anak-anak. Berbagai muatan kekerasan,hedonisme, konsumerisme, mistik, pornografi dan budaya instan hadir dalam setiap keluargamelalui televisi. Hal ini membuktikan bahwa televisi memiliki dua wajah: wajah baik dan wajahburuk. Sementara banyak orang tua tidak memiliki cukup waktu untuk menjaga anak-anaknyadari terpaan wajah buruk media. Anak belum memiliki kemampuan filtrasi aktif, oleh karena ituorang dewasa dalam hal ini orang tua dituntut untuk memberikan pendidikan media pada anak.Idealnya pendidikan media diberikan di jenjang usia dini. Sejak pertama kali anak dapatberinteraksi dengan media. Namun untuk melakukan pendidikan media pada anak usia dinibukanlah hal yang

  12. Intravenous glutamine enhances COX-2 activity giving cardioprotection.

    LENUS (Irish Health Repository)

    McGuinness, Jonathan

    2009-03-01

    Preconditioning, a highly evolutionary conserved endogenous protective response, provides the most powerful form of anti-infarct protection known. We investigated whether acute intravenous glutamine, through an effect on cyclooxygenase (COX)-2 and heat shock protein (HSP) 72, might induce preconditioning.

  13. Frihet & struktur : en kvalitativ studie av skolelivskvalitet hos ungdom med Tourette syndrom

    OpenAIRE

    Siverts, Torstein

    2005-01-01

    Sammendrag. Tittel: Skolelivskvalitet hos ungdom med Tourette Syndrom Med bakgrunn i egen erfaring fra arbeid med elever med Tourette Syndrom i grunnskolen, og i studier i spesialpedagogisk teori og empiri, etterstrebes det i denne studien å utvikle økt forståelse for hva slags erfaringer fra og perspektiver på sitt skoleliv elever med denne funksjonshemmende lidelsen har. Med grunnlag i analyser av intervjuer med elever om deres erfaringer og perspektiver, har jeg prøvd å b...

  14. Proteomic Analysis Shows Constitutive Secretion of MIF and p53-associated Activity of COX-2−/− Lung Fibroblasts

    Directory of Open Access Journals (Sweden)

    Mandar Dave

    2017-12-01

    Full Text Available The differential expression of two closelyassociated cyclooxygenase isozymes, COX-1 and COX-2, exhibited functions beyond eicosanoid metabolism. We hypothesized that COX-1 or COX-2 knockout lung fibroblasts may display altered protein profiles which may allow us to further differentiate the functional roles of these isozymes at the molecular level. Proteomic analysis shows constitutive production of macrophage migration inhibitory factor (MIF in lung fibroblasts derived from COX-2−/− but not wild-type (WT or COX-1−/− mice. MIF was spontaneously released in high levels into the extracellular milieu of COX2−/− fibroblasts seemingly from the preformed intracellular stores, with no change in the basal gene expression of MIF. The secretion and regulation of MIF in COX-2−/− was “prostaglandin-independent.” GO analysis showed that concurrent with upregulation of MIF, there is a significant surge in expression of genes related to fibroblast growth, FK506 binding proteins, and isomerase activity in COX-2−/− cells. Furthermore, COX-2−/− fibroblasts also exhibit a significant increase in transcriptional activity of various regulators, antagonists, and co-modulators of p53, as well as in the expression of oncogenes and related transcripts. Integrative Oncogenomics Cancer Browser (IntroGen analysis shows downregulation of COX-2 and amplification of MIF and/or p53 activity during development of glioblastomas, ependymoma, and colon adenomas. These data indicate the functional role of the MIF-COX-p53 axis in inflammation and cancer at the genomic and proteomic levels in COX-2-ablated cells. This systematic analysis not only shows the proinflammatory state but also unveils a molecular signature of a pro-oncogenic state of COX-1 in COX-2 ablated cells.

  15. APPLICATION OF ESSENTIAL OILS EXTRACTED FROM PEELS OF ORANGES AS A PARTIAL SUBSTITUTE OF FLOCCULANT

    Directory of Open Access Journals (Sweden)

    Anna Kowalczyk

    2016-05-01

    Full Text Available The study attempts to determine the optimum conditions of the process of mechanical dewatering of municipal sewage sludge and reduction of odours emitted during this process. The process of dewatering of municipal sewage sludge was carried out using laboratory sedimentation centrifuge of MPW-350 type. Municipal sewage sludge stabilized during anaerobic digestion, taken from Wastewater Treatment Plant Jamno. The dewatering process was aided by cationic flocculant Praestol 855BS of real solution concentration 0.3% and essential oil from orange, which was extracted from orange peels in the process of steam distillation. Constant parameters of dewatering process were: pH, temperature, colour, texture, smell, water content and dry matter content. Independent variables of dewatering process were: centrifugation time (in the range 1–10 min, centrifugation speed (in the range 1000–3000 rotations/min and dose of mixture of flocculant Praestol 855BS (79% + essential oil of orange (21% in the range 0–48 ml/dm3. Water content in the sludge after the process, dry matter content in the effluent and the duration of the smell of oil in the sediment were determined. Studies showed that the essential oil from orange may be used as a partial substitute of flocculant Praestol 855BS in the process of centrifugal sedimentation. Essential oil of orange significantly reduces unpleasant odours which are emitted from sludge during mechanical dewatering. Simultaneous application of both reagents, ie. flocculant Praestol 855BS 79%, and essential oil of orange 21% of volume is recommended.

  16. Direct-to-consumer advertising of COX-2 inhibitors: effect on appropriateness of prescribing.

    Science.gov (United States)

    Spence, Michele M; Teleki, Stephanie S; Cheetham, T Craig; Schweitzer, Stuart O; Millares, Mirta

    2005-10-01

    Spending on direct-to-consumer advertising (DTCA) of prescription drugs has increased dramatically in the past several years. An unresolved question is whether such advertising leads to inappropriate prescribing. In this study, the authors use survey and administrative data to determine the association of DTCA with the appropriate prescribing of cyclooxygenase-2 (COX-2) inhibitors for 1,382 patients. Treatment with either a COX-2 or a traditional nonsteroidal anti-inflammatory drug (NSAID) was defined as appropriate or not according to three different definitions of gastrointestinal risk. Patients who saw or heard a COX-2 advertisement and asked their physician about the advertised drug were significantly more likely to be prescribed a COX-2 (versus a NSAID, as recommended by evidence-based guidelines) than all other patients. Findings also suggest that some patients may benefit from DTCA. The authors discuss the need for balanced drug information for consumers, increased physician vigilance in prescribing appropriately, and further study of DTCA.

  17. Spilleregler i musikterapi med børn

    DEFF Research Database (Denmark)

    Holck, Ulla

    2005-01-01

    Artiklen gennemgår udvalgte eksempler på anvendelse af spilleregler i musikterapi med børneklientgrupper. Efter en kort introduktion af Priestleys syn på analytisk musikterapi med børn, præsenteres læseren således for en række caseeksempler fra faglitteraturen, der giver indblik i udformning og a...

  18. Forsøg med Hi-Con altanelement

    DEFF Research Database (Denmark)

    Hansen, Lars Pilegaard

    Denne rapport beskriver forsøg udført på Laboratoriet for Bærende Konstruktioner, Aalborg Universitet med et altanelement leveret af Hi-Con Aps, Hjallerup. Forsøgene er udført i september 2002. Forsøgene omfatter en statisk prøvning, hvor altanelementet blev belastet med sandsække og nedbøjningerne...

  19. Rutsjende dug - breddeopgave 73 med didaktisk kommentar

    DEFF Research Database (Denmark)

    Jensen, Jens Højgaard

    2017-01-01

    Mit formål med artikelserien om breddeopgaver er - udover at gøre opmærksom på RUCs fysikuddannelse - dobbelt: Dels udvælger jeg opgaverne, så de kan have interesse som fysikproblemer i egen ret. Dels udvælger jeg dem med henblik på at kunne knytte didaktiske overvejelser til dem af interesse for...

  20. 75 FR 1010 - CSX Transportation, Inc.-Discontinuance of Service Exemption-in Clark, Floyd, Lawrence, Orange...

    Science.gov (United States)

    2010-01-07

    ... DEPARTMENT OF TRANSPORTATION Surface Transportation Board [STB Docket No. AB-55 (Sub-No. 698X)] CSX Transportation, Inc.--Discontinuance of Service Exemption--in Clark, Floyd, Lawrence, Orange, and..., Orange, and Washington Counties, IN.\\1\\ The line traverses United States Postal Service Zip Codes 47150...

  1. Consumer acceptance of orange juice mixed with water mint leave extract.

    Science.gov (United States)

    Ali, Marwa Rashad

    2017-10-31

    Orange-Mint leaves juice was formulated using different addition percentages of mint leaves extract. The juice was aseptically processed, packed in glass bottles under sterilized environment and sterilized at 70°C for 15 minutes then storage at 5°C for 3 months. The physicochemical, nutritional value, microbiological and sensory characteristics of the juice was evaluated. There is no difference in pH, total soluble solids, ash, and total acidity in all samples moreover, the sample A2, "orange juice with 15% of mint leaves extract" recorded the best values of sensory evaluation, on the other hand, it was recorded lower values of vitamin C and total phenolic compound than sample (C) or (C1) because of increasing in addition% of mint leaves extract to orange juice. The sensory properties of juice samples were not remarkable any changes during storage. The result indicated that the juice was acceptable up to 3 months of storage 5°C. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.org.

  2. Bayesian analysis of log Gaussian Cox processes for disease mapping

    DEFF Research Database (Denmark)

    Benes, Viktor; Bodlák, Karel; Møller, Jesper

    We consider a data set of locations where people in Central Bohemia have been infected by tick-borne encephalitis, and where population census data and covariates concerning vegetation and altitude are available. The aims are to estimate the risk map of the disease and to study the dependence...... of the risk on the covariates. Instead of using the common area level approaches we consider a Bayesian analysis for a log Gaussian Cox point process with covariates. Posterior characteristics for a discretized version of the log Gaussian Cox process are computed using markov chain Monte Carlo methods...

  3. Orange juice as dietary source of antioxidants for patients with hepatitis C under antiviral therapy.

    Science.gov (United States)

    Gonçalves, Danielle; Lima, Claudia; Ferreira, Paula; Costa, Paulo; Costa, Angela; Figueiredo, Walter; Cesar, Thais

    2017-01-01

    Background: HCV causes alterations in liver metabolism, resulting in biochemical and nutritional disorders. Supplementation with antioxidants has been suggested to minimize the diseases effects. Objective: This study assessed whether orange juice, a source of citrus flavonoids and vitamin C, may contribute to the treatment of patients with chronic hepatitis C. Design: Anthropometric, hemodynamic, dietary, and biochemical parameters, CRP and liver enzymes were measured in 43 adult patients of both genders who were diagnosed with chronic hepatitis C and were under antiviral therapy. Twenty-three patients were supplemented with orange juice for eight consecutive weeks, while 20 were enrolled as control group. Results: Following regular use of orange juice, no alterations were found in body mass, fat, and waist circumference. The serum levels of total cholesterol, LDL-cholesterol, CRP and parameters of oxidative stress decreased in the orange juice group. Furthermore, the levels of the liver enzyme AST decreased in those who had high levels before the intervention. Conclusion: The orange juice was a convenient food in the diet of patients due to the increase in antioxidant capacity and decreased inflammation and cholesterol in blood serum, in addition to maintaining body mass, which protect against the harmful effects caused by the chronic hepatitis C virus.​​​.

  4. Optimization of extraction of microcrystalline cellulose from orange ...

    African Journals Online (AJOL)

    This study investigated the optimum processing conditions for obtaining the maximum yield of microcrystalline cellulose (MCC) powder from orange peel waste (OPW) by use of response surface methodology (RSM). Central composite design (CCD) was used to evaluate the optimum process conditions for producing MCC ...

  5. Effects of irradiation in combination with waxing on the essential oils in orange peel

    International Nuclear Information System (INIS)

    Moussaid, M.; Lacroix, M.; Nketsia-Tabiri, J.; Boubekri, C.

    2000-01-01

    The study evaluated the effects of waxing and irradiation dose on the essential oils in orange peel. Mature oranges (Maroc late) waxed or unwaxed were treated with 0-2 kGy radiation. Volatiles in the peel were extracted and analyzed by G.C. D-limonene was significantly lower (P≤0.05) in waxed oranges; levels in samples treated with 2 kGy were higher than those treated with 0 or 1 kGy. Linalool, methyl anthranilate and 3.7-dimethyl-2.6-octadienal decreased as the dose increased. The analysis of variance indicates that only linalool was influenced by post-irradiation storage time. The level of this compound increased with storage time. (author)

  6. A magnetic-lens - mini-orange coincidence spectrometer

    International Nuclear Information System (INIS)

    Bargholtz, C.; Holmberg, L.; Ruus, N.; Tegner, P.E.; Weiss, G.

    1997-04-01

    A coincidence spectrometer consisting of a Gerholm type magnetic lens and a permanent magnet mini-orange spectrometer is described. Electron-electron or electron-positron coincidences may be registered in various angular settings. The spectrometer has been developed mainly to search for anomalous contributions to Bhabha scattering or positrons and is at present used for such studies. 6 refs

  7. Predicting and Modelling of Survival Data when Cox's Regression Model does not hold

    DEFF Research Database (Denmark)

    Scheike, Thomas H.; Zhang, Mei-Jie

    2002-01-01

    Aalen model; additive risk model; counting processes; competing risk; Cox regression; flexible modeling; goodness of fit; prediction of survival; survival analysis; time-varying effects......Aalen model; additive risk model; counting processes; competing risk; Cox regression; flexible modeling; goodness of fit; prediction of survival; survival analysis; time-varying effects...

  8. Succinic acid production from orange peel and wheat straw by batch fermentations of Fibrobacter succinogenes S85.

    Science.gov (United States)

    Li, Qiang; Siles, Jose A; Thompson, Ian P

    2010-10-01

    Succinic acid is a platform molecule that has recently generated considerable interests. Production of succinate from waste orange peel and wheat straw by consolidated bioprocessing that combines cellulose hydrolysis and sugar fermentation, using a cellulolytic bacterium, Fibrobacter succinogenes S85, was studied. Orange peel contains D-limonene, which is a well-known antibacterial agent. Its effects on batch cultures of F. succinogenes S85 were examined. The minimal concentrations of limonene found to inhibit succinate and acetate generation and bacterial growth were 0.01%, 0.1%, and 0.06% (v/v), respectively. Both pre-treated orange peel by steam distillation to remove D: -limonene and intact wheat straw were used as feedstocks. Increasing the substrate concentrations of both feedstocks, from 5 to 60 g/L, elevated succinate concentration and productivity but lowered the yield. In addition, pre-treated orange peel generated greater succinate productivities than wheat straw but had similar resultant titres. The greatest succinate titres were 1.9 and 2.0 g/L for pre-treated orange peel and wheat straw, respectively. This work demonstrated that agricultural waste such as wheat straw and orange peel can be biotransformed to succinic acid by a one-step consolidated bioprocessing. Measures to increase fermentation efficiency are also discussed.

  9. Digital kommunikation med den offentlige sektor

    DEFF Research Database (Denmark)

    Berger, Jesper Bull; Andersen, Kim Normann

    til. I denne undersøgelse sættes der fokus på myndighedernes besvarelse af den digitale post. Digital post blev bl.a. etableret som et alternativ til almindelig e-mail for at det offentlige kan kommunikere med borgere og virksomheder på en sikker måde, dvs. uden at uvedkommende kan få adgang til...... følsomme oplysninger. Fokus for undersøgelsen er hvordan håndterer myndighederne besvarelserne i den digitale postkasse: svarer de på digital post og e-mail, hvor hurtigt svarer de og er svarene brugbare? Undersøgelsen medtager myndighedernes besvarelse af digital post og e-mail, dels for at kunne...... sammenligne de to digitale kanaler og for at kunne sammenligne med en tidligere undersøgelse af digital kommunikation med det offentlige. Herudover er der tidligere gennemført en undersøgelse af e-mail svar og svartider i New Zealand og Australien. De danske resultater fra e-mail undersøgelsen, men ikke...

  10. Skin color variation in Orang Asli tribes of Peninsular Malaysia.

    Directory of Open Access Journals (Sweden)

    Khai C Ang

    Full Text Available Pigmentation is a readily scorable and quantitative human phenotype, making it an excellent model for studying multifactorial traits and diseases. Convergent human evolution from the ancestral state, darker skin, towards lighter skin colors involved divergent genetic mechanisms in people of European vs. East Asian ancestry. It is striking that the European mechanisms result in a 10-20-fold increase in skin cancer susceptibility while the East Asian mechanisms do not. Towards the mapping of genes that contribute to East Asian pigmentation there is need for one or more populations that are admixed for ancestral and East Asian ancestry, but with minimal European contribution. This requirement is fulfilled by the Senoi, one of three indigenous tribes of Peninsular Malaysia collectively known as the Orang Asli. The Senoi are thought to be an admixture of the Negrito, an ancestral dark-skinned population representing the second of three Orang Asli tribes, and regional Mongoloid populations of Indo-China such as the Proto-Malay, the third Orang Asli tribe. We have calculated skin reflectance-based melanin indices in 492 Orang Asli, which ranged from 28 (lightest to 75 (darkest; both extremes were represented in the Senoi. Population averages were 56 for Negrito, 42 for Proto-Malay, and 46 for Senoi. The derived allele frequencies for SLC24A5 and SLC45A2 in the Senoi were 0.04 and 0.02, respectively, consistent with greater South Asian than European admixture. Females and individuals with the A111T mutation had significantly lighter skin (p = 0.001 and 0.0039, respectively. Individuals with these derived alleles were found across the spectrum of skin color, indicating an overriding effect of strong skin lightening alleles of East Asian origin. These results suggest that the Senoi are suitable for mapping East Asian skin color genes.

  11. Reação da laranjeira azêda à tristeza Reaction of the sour orange plant to tristeza

    Directory of Open Access Journals (Sweden)

    A. S. Costa

    1954-01-01

    plantas sadias se desenvolvem mais ou menos satisfatòriamente quando sôbre-enxertadas em galhos de laranjeira doce sobre laranjeira azêda, já em avançado estado de declínio. Uma copa mista de laranjeiras azêda e doce sôbre cavalo de azêda pode causar alguns benefícios à planta afetada pela tristeza sob determinadas condições, mas êsse benefício não é duradouro e o método não oferece possibilidades práticas. A laranjeira azêda em viveiro tem sido utilizada com vantagem na determinação da presença do vírus da tristeza em borbulhas de vários tipos de Citrus, pela observação do crescimento feito a partir dessas borbulhas em comparação com aquêle de borbulhas da mesma variedade garantidamente sadias. Para a determinação da presença de estirpes fracas do vírus o método é mais demorado. Interenxertos de laranjeira azêda entre copas e raízes de laranjeira doce são suficientes para que haja manifestação de sintomas da moléstia. Há aparentemente alguma translocação através do interenxêrto, pois o desenvolvimento do cavalo abaixo e acima dele é aproximadamente igual.Young sour orange seedlings are more easily infected with the tristeza virus by approach-grafts than by means of the aphid vector. Under natural conditions adult plants in the field are highly resistant to infection by the aphid vector. Recovery of the tristeza virus from infected sour orange plants is also more easily accomplished by tissue union than by means of the aphid vector. Sour orange seedlings show yellowing of young leaves followed by stunting and shedding of leaves when infected with the ordinary strain of the tristeza virus in Brazil. These symptoms do not differ from those described for seedling yellows. The symptoms of leaf yellowing are less evident in plants infected with mild strains of the tristeza virus and there is subsequent recovery. New flushes of young leaves may show occasional vein dashes. Sour orange tissues below the bud union of the sweet

  12. IL1β-mediated Stromal COX-2 signaling mediates proliferation and invasiveness of colonic epithelial cancer cells

    International Nuclear Information System (INIS)

    Zhu, Yingting; Zhu, Min; Lance, Peter

    2012-01-01

    COX-2 is a major inflammatory mediator implicated in colorectal inflammation and cancer. However, the exact origin and role of COX-2 on colorectal inflammation and carcinogenesis are still not well defined. Recently, we reported that COX-2 and iNOS signalings interact in colonic CCD18Co fibroblasts. In this article, we investigated whether activation of COX-2 signaling by IL1β in primary colonic fibroblasts obtained from normal and cancer patients play a critical role in regulation of proliferation and invasiveness of human colonic epithelial cancer cells. Our results demonstrated that COX-2 level was significantly higher in cancer associated fibroblasts than that in normal fibroblasts with or without stimulation of IL-1β, a powerful stimulator of COX-2. Using in vitro assays for estimating proliferative and invasive potential, we discovered that the proliferation and invasiveness of the epithelial cancer cells were much greater when the cells were co-cultured with cancer associated fibroblasts than with normal fibroblasts, with or without stimulation of IL1β. Further analysis indicated that the major COX-2 product, prostaglandin E 2 , directly enhanced proliferation and invasiveness of the epithelial cancer cells in the absence of fibroblasts. Moreover, a selective COX-2 inhibitor, NS-398, blocked the proliferative and invasive effect of both normal and cancer associate fibroblasts on the epithelial cancer cells, with or without stimulation of IL-1β. Those results indicate that activation of COX-2 signaling in the fibroblasts plays a major role in promoting proliferation and invasiveness of the epithelial cancer cells. In this process, PKC is involved in the activation of COX-2 signaling induced by IL-1β in the fibroblasts.

  13. Histamine, carbachol, and serotonin induce hyperresponsiveness to ATP in guinea pig tracheas: involvement of COX-2 pathway.

    Science.gov (United States)

    Montaño, Luis M; Carbajal, Verónica; Vargas, Mario H; García-Hernández, Luz M; Díaz-Hernández, Verónica; Checa, Marco; Barajas-López, Carlos

    2013-08-01

    Extracellular ATP promotes an indirect contraction of airway smooth muscle via the secondary release of thromboxane A2 (TXA2) from airway epithelium. Our aim was to evaluate if common contractile agonists modify this response to ATP. Tracheas from sensitized guinea pigs were used to evaluate ATP-induced contractions before and after a transient contraction produced by histamine, carbachol, or serotonin. Epithelial mRNA for COX-1 and COX-2 was measured by RT-PCR and their expression assessed by immunohistochemistry. Compared with the initial response, ATP-induced contraction was potentiated by pretreatment with histamine, carbachol, or serotonin. Either suramin (antagonist of P2X and P2Y receptors) plus RB2 (antagonist of P2Y receptors) or indomethacin (inhibitor of COX-1 and COX-2) annulled the ATP-induced contraction, suggesting that it was mediated by P2Y receptor stimulation and TXA2 production. When COX-2 was inhibited by SC-58125 or thromboxane receptors were antagonized by SQ-29548, just the potentiation was abolished, leaving the basal response intact. Airway epithelial cells showed increased COX-2 mRNA after stimulation with histamine or carbachol, but not serotonin, while COX-1 mRNA was unaffected. Immunochemistry corroborated this upregulation of COX-2. In conclusion, we showed for the first time that histamine and carbachol cause hyperresponsiveness to ATP by upregulating COX-2 in airway epithelium, which likely increases TXA2 production. Serotonin-mediated hyperresponsiveness seems to be independent of COX-2 upregulation, but nonetheless is TXA2 dependent. Because acetylcholine, histamine, and serotonin can be present during asthmatic exacerbations, their potential interactions with ATP might be relevant in its pathophysiology.

  14. Distillation of Essential Oils from Pontianak Orange Peel Wastes and Its Utilization for Aromatherapy Soap

    Directory of Open Access Journals (Sweden)

    Hidayati Hidayati

    2012-12-01

    Full Text Available Orange (Citrus nobilis var. microcarpa is the main commodities in Pontianak. Production of essential oils from orange peel wastes and its use for soap aromatherapy substance could improve its economic value. This study is aimed to produce the essential oils from orange peel wastes with the highest limonene content by distillation. Its application for aromatherapy soap substance also evaluated. Distillation of essential oils from orange peels was performed at 1000C and 1100C for 4, 5, 6 and 7 hours. The results showed that at 1000C for 7 hours produced the highest limonene content, reach 97.69%. The essential oils color was pale yellow, specific gravity 0.84, refractive index 1.47, solubility in 90% ethanol 1:1 (transparent, acid value 0.143% and ester number 5.37. The aromatherapy soap produced with addition of 3.6% of limonene oils is in accordance with SNI 06-3532-1994 except for water content parameter.

  15. Selection of the optimal Box-Cox transformation parameter for modelling and forecasting age-specific fertility

    OpenAIRE

    Shang, Han Lin

    2015-01-01

    The Box-Cox transformation can sometimes yield noticeable improvements in model simplicity, variance homogeneity and precision of estimation, such as in modelling and forecasting age-specific fertility. Despite its importance, there have been few studies focusing on the optimal selection of Box-Cox transformation parameters in demographic forecasting. A simple method is proposed for selecting the optimal Box-Cox transformation parameter, along with an algorithm based on an in-sample forecast ...

  16. Mellem nyliberalisme og terror - Interview med Chantal Mouffe

    DEFF Research Database (Denmark)

    Hansen, Allan Dreyer; Sonnichsen, André

    2012-01-01

    Interview med Chantal Mouffe om Hegemony and Socalist Strategy, modstandere og fjender en ny multipolær verdensorden og demokrati......Interview med Chantal Mouffe om Hegemony and Socalist Strategy, modstandere og fjender en ny multipolær verdensorden og demokrati...

  17. Effektelektronik - teknologi med energibesparelser og forbedret performance

    DEFF Research Database (Denmark)

    Blaabjerg, Frede

    2004-01-01

    Lige siden transistoren blev opfundet, har det altid været ønskeligt at kunne anvende en sådan til at styre store strømme/spændinger i elektriske systemer. Det er teknologisk også sket, først med tyristorer til styring af store effekter, men siden hen også med den bipolare transistor MOSFET, samt...

  18. The satisfaction level of indigenous people towards planned housing development. Case study: Orang Asli Kg. Sejagong, Sri Medan, Yong Peng Johor

    Science.gov (United States)

    Kamaruddin, S. M.; Zaini, N. S.; Misni, A.; Ahmad, P.

    2018-02-01

    Orang Asli possesses a unique relationship with their traditional land. Indigenous people have their thoughts on development, life values, visions, needs, and priorities. The government through Department of Orang Asli Development or Jabatan Kebajikan Orang Asli (JAKOA) implemented various development programs such as structured settlement program, physical improvements such as Regrouping Plan (RPS), Village Restructuring project (PSK), New Village Plan (RKB) and Orang Asli settlement customary Land Survey (village) / Land Acquisition. Orang Asli Community. However, their sense of satisfaction towards the development implemented is rarely evaluated. This paper aims to highlight Orang Asli’s thoughts and level of satisfaction towards the planned housing development of their settlement. A mixed methodology was employed using survey and interview to record their thoughts. The findings suggest that the Orang Asli Community’s sense of satisfaction towards housing development has improved. However, their needs to adhere to their social traditions and norms such as living adjacent to relatives, surrounded by nature within a low-density environment must be respected.

  19. Ny viden begynder med forhindringer

    DEFF Research Database (Denmark)

    Johansen, Martin Blok

    2017-01-01

    Pædagogik og pædagogisk arbejde diskuteres typisk inden for rammerne af det at hjælpe, støtte, simplificere og kompleksitetsreducere. Hvis man ønsker at vide noget om forhindringer, modstand og vanskeligheder som pædagogiske muligheder, så er udbuddet derimod forsvindende småt. Og når sådanne...... begreber endelig tages op, så benævnes de typisk blot, men bliver sjældent defineret. Hvad menes der med modstand, vanskeligheder eller kompleksitet? Med afsæt i en kort gennemgang af eksisterende forskning på området forsøger denne artikel at give et bud på en mulig definition af begrebet forhindring...

  20. Pteridine, not carotenoid, pigments underlie the female-specific orange ornament of striped plateau lizards (Sceloporus virgatus).

    Science.gov (United States)

    Weiss, S L; Foerster, K; Hudon, J

    2012-02-01

    Indicator models of sexual selection suggest that signal honesty is maintained via costs of ornament expression. Carotenoid-based visual signals are a well-studied example, as carotenoids may be environmentally limited and impact signaler health. However, not all bright yellow, orange and red ornaments found in vertebrates are carotenoid-based; pteridine pigments may also produce these colors. We examine the contribution of carotenoid and pteridine pigments to the orange reproductive color of female striped plateau lizards (Sceloporus virgatus). This color ornament reliably indicates female mate quality, yet costs maintaining signal honesty are currently unknown. Dietary carotenoid manipulations did not affect orange color, and orange skin differed from surrounding white skin in drosopterin, not carotenoid, content. Further, orange color positively correlated with drosopterin, not carotenoid, concentration. Drosopterin-based female ornaments avoid the direct trade-offs of using carotenoids for ornament production vs egg production, thus may relax counter-selection against color ornament exaggeration in females. Direct experimentation is needed to determine the actual costs of pteridine-based ornaments. Like carotenoids, pteridines influence important biological processes, including immune and antioxidant function; predation and social costs may also be relevant. Copyright © 2011 Elsevier Inc. All rights reserved.

  1. Sub-nanosecond lifetime measurements using the Double Orange Spectrometer at the cologne 10 MV Tandem accelerator

    International Nuclear Information System (INIS)

    Regis, J.-M.; Materna, Th.; Christen, S.; Bernards, C.; Braun, N.; Breuer, G.; Fransen, Ch.; Heinze, S.; Jolie, J.; Meersschaut, T.; Pascovici, G.; Rudigier, M.; Steinert, L.; Thiel, S.; Warr, N.; Zell, K.O.

    2009-01-01

    Conversion electron spectroscopy constitutes an important tool in nuclear structure physics. A high efficiency iron-free Orange type electron spectrometer with an energy resolution of 1-2% has been installed at a beam line of the Cologne 10 MV FN Tandem Van-de-Graaff accelerator for in-beam studies of conversion electrons. In combination with a γ-ray detector array, high efficiency e - -γ-coincidences can be performed. The newly developed very fast LaBr 3 (Ce) scintillator detector with an energy resolution of about 4% makes it also possible to use e - -γ-coincidences for lifetime measurements of nuclear excited states. A second iron-free Orange spectrometer can be connected to perform e - -e - -coincidences. Because of the higher efficiency and the better energy resolution, the use of the Double Orange Spectrometer for lifetime measurements is more powerful. Lifetimes down to 100 ps and even less can be determined with an accuracy of about 10 ps. The working principle of the Orange spectrometer and the setup of the Double Orange Spectrometer are described. The performances are illustrated by examples of in-beam experiments with a main focus on high precision lifetime measurements.

  2. Psykomotorisk behandling og wellness til personer med demens

    DEFF Research Database (Denmark)

    Stamp, Anne Schinkel; Frausing, Kristian Park

    Rapporten evaluerer projektet Psykomotorisk behandling af personer med demens gennem fokusgruppeinterviews med deltagende studerende og personale fra deltagende centre. Samlet peges der på gavnligt udbytte for de demente beboere samt både personligt og fagligt udbytte for de deltagende studerende...

  3. A computational prospect to aspirin side effects: aspirin and COX-1 interaction analysis based on non-synonymous SNPs.

    Science.gov (United States)

    Marjan, Mojtabavi Naeini; Hamzeh, Mesrian Tanha; Rahman, Emamzadeh; Sadeq, Vallian

    2014-08-01

    Aspirin (ASA) is a commonly used nonsteroidal anti-inflammatory drug (NSAID), which exerts its therapeutic effects through inhibition of cyclooxygenase (COX) isoform 2 (COX-2), while the inhibition of COX-1 by ASA leads to apparent side effects. In the present study, the relationship between COX-1 non-synonymous single nucleotide polymorphisms (nsSNPs) and aspirin related side effects was investigated. The functional impacts of 37 nsSNPs on aspirin inhibition potency of COX-1 with COX-1/aspirin molecular docking were computationally analyzed, and each SNP was scored based on DOCK Amber score. The data predicted that 22 nsSNPs could reduce COX-1 inhibition, while 15 nsSNPs showed increasing inhibition level in comparison to the regular COX-1 protein. In order to perform a comparing state, the Amber scores for two Arg119 mutants (R119A and R119Q) were also calculated. Moreover, among nsSNP variants, rs117122585 represented the closest Amber score to R119A mutant. A separate docking computation validated the score and represented a new binding position for ASA that acetyl group was located within the distance of 3.86Å from Ser529 OH group. This could predict an associated loss of activity of ASA through this nsSNP variant. Our data represent a computational sub-population pattern for aspirin COX-1 related side effects, and provide basis for further research on COX-1/ASA interaction. Copyright © 2014 Elsevier Ltd. All rights reserved.

  4. Inkludering av ungdom med minoritetsbakgrunn i NIF-organisert idrett

    Directory of Open Access Journals (Sweden)

    Mari Kristin Sisjord

    2014-10-01

    Full Text Available Norges Idrettsforbund og Olympiske og Paralympiske Komité (NIF har en uttalt målsetting om en åpen og inkluderende idrett. Hvordan kommer dette til uttrykk i den praktiske virksomheten? Denne artikkelen, som bygger på data fra en undersøkelse om likestilling og mangfold i den organiserte idretten (NIF, retter søkelyset mot arbeid med inklusjon av ungdom med minoritetsbakgrunn på ulike organisasjonsnivå i NIF: særforbund, idrettskretser og idrettslag. Datamaterialet er kvalitative intervju med representanter fra ulike organisasjonsnivå. Resultatene viser at NIFs overordnede politikk i varierende grad nedfelles i særforbundenes virksomhet, i idrettskretsene og i idrettslagene. Av særforbundene skiller Fotballforbundet og Klatreforbundet seg ut som aktive pådrivere i arbeidet med inkludering. Mange idrettslag oppfattet slike spørsmål som lite aktuelle i sitt rekrutteringsområde. Representanter for lag som hadde erfaring med inkludering og rekruttering av minoritetsungdom, tilkjennega varierte erfaringer og synspunkter.

  5. β-Cryptoxanthin and Zeaxanthin Pigments Accumulation to Induce Orange Color on Citrus Fruits

    Science.gov (United States)

    Hidayati Sumiasih, Inanpi; Poerwanto, Roedhy; Efendi, Darda; Agusta, Andria; Yuliani, Sri

    2018-01-01

    Degreening, a transformation process of green color on citrus peel to be orange color on tropical low-land citrus fruits often fails. Orange color of the citrus peel comes from the mixture carotenoid pigments, such as zeaxanthine and mainly β-cryptoxanthin and β-citraurin. The accumulation of β-citraurin occurs when the fruits are exposed to low temperature, and otherwise, it will fail to occur. Precooling treatment on lowland tropical citrus fruits is expected to stimulate the accumulation of β-citraurin. The results showed the most favorable color obtained from precooling and 24-hour ethylene exposure duration. This treatment could decrease total chlorophyll and β-carotene content as well as proven to increase 3 times the accumulation of β-cryptoxanthin in accelerating the appearance of bright orange color on citrus peel. Degreening gave no significant effect to internal quality of Citrus reticulata.

  6. Estradiol-induced antinociceptive responses on formalin-induced nociception are independent of COX and HPA activation.

    Science.gov (United States)

    Hunter, Deirtra A; Barr, Gordon A; Amador, Nicole; Shivers, Kai-Yvonne; Kemen, Lynne; Kreiter, Christopher M; Jenab, Shirzad; Inturrisi, Charles E; Quinones-Jenab, Vanya

    2011-07-01

    Estrogen modulates pain perception but how it does so is not fully understood. The aim of this study was to determine if estradiol reduces nociceptive responses in part via hypothalamic-pituitary-adrenal (HPA) axis regulation of cyclooxygenase (COX)-1/COX-2 activity. The first study examined the effects of estradiol (20%) or vehicle with concurrent injection nonsteroidal antiinflammatory drugs (NSAIDs) on formalin-induced nociceptive responding (flinching) in ovariectomized (OVX) rats. The drugs were ibuprofen (COX-1 and COX-2 inhibitor), SC560 (COX-1 inhibitor), or NS398 (COX-2 inhibitor). In a second study, estradiol's effects on formalin-induced nociception were tested in adrenalectomized (ADX), OVX, and ADX+OVX rats. Serum levels of prostaglandins (PG) PGE(2) and corticosterone were measured. Estradiol significantly decreased nociceptive responses in OVX rats with effects during both the first and the second phase of the formalin test. The nonsteroidal antiinflammatory drugs (NSAIDs) did not alter nociception at the doses used here. Adrenalectomy neither altered flinching responses in female rats nor reversed estradiol-induced antinociceptive responses. Estradiol alone had no effect on corticosterone (CORT) or prostaglandin levels after the formalin test, dissociating the effects of estradiol on behavior and these serum markers. Ibuprofen and NS398 significantly reduced PGE2 levels. CORT was not decreased by OVX surgery or by estradiol below that of ADX. Only IBU significantly increased corticosterone levels. Taken together, our results suggest that estradiol-induced antinociception in female rats is independent of COX activity and HPA axis activation. Copyright © 2010 Wiley-Liss, Inc.

  7. KORELASI ANTARA KEAKRABAN ANAK DAN ORANG TUA DENGAN HUBUNGAN SOSIAL ASOSIATIF MELALUI KOMUNIKASI ANTAR PRIBADI

    Directory of Open Access Journals (Sweden)

    Tri Wahyuti

    2016-05-01

    Full Text Available Inter-Personal Communication (KAP becomes the most important part of an individual in interacting with others. In the smallest environment, ie family, we can find out how KAP activities between children and parents occur. Children can tell stories and open themselves to their parents and vice versa. The quality of a good KAP will certainly have a positive impact on good relationships between children and parents. This can certainly affect the quality of social interaction of children outside the family environment, especially regarding aspects of associative social relationships that run in everyday activities. Through the KAP based on trust, honesty, affection, responsibility and self-disclosure, is expected to establish intimacy between individuals. The study looked at the extent of the correlation between intimacy between Paramadina University students and their parents with ascetic social relationships in everyday life. The research used quantitative methodology with survey method. The population of this research is Paramadina University Communication students Genap 2014/2015, which amounts to. 290 people. Using a tolerance level of 10%, the sample in this study was 75 people. The results showed that there was a significant correlation between familial and student relationship relation to associative social relationship (strong relationship.   Komunikasi Antar Pribadi (KAP menjadi bagian paling penting seorang individu dalam berinteraksi dengan orang lain. Dalam lingkungan paling kecil, yaitu keluarga, kita dapat menemukan bagaimana kegiatan KAP antara anak dan orang tua terjadi. Anak-anak dapat bercerita dan membuka diri kepada orang tuanya dan begitu pun sebaliknya. Kualitas KAP yang baik tentu akan berdampak positif pada hubungan yang baik antara anak dan orang tua. Hal ini tentu dapat memengaruhi kualitas interaksi sosial anak di luar lingkungan keluarganya, terutama menyangkut aspek hubungan sosial asosiatif yang dijalankannya dalam

  8. Synthesis and application of multiple rods gold-zinc oxide nano structures in the photo catalytic degradation of methyl orange

    International Nuclear Information System (INIS)

    Arab Chamjangali, M.; Bagherian, G.; Bahramian, B.; Fahimi Rad, B.

    2015-01-01

    Zinc oxide and gold-zinc oxide (Au-Zn O) nano structures with multiple rods (multi pods) morphology were successfully prepared. Au-Zn O nano structures were synthesized via a simple precipitation route method in the presence of oligo aniline-coated gold nanoparticles. The Au-Zn O catalyst obtained was applied for the degradation of methyl orange in an aqueous solution under UV irradiation Effects of the operational parameters such as the solution p H, amount of photocatalyst, and dye concentration on the photo catalytic degradation and decolorisation of methyl orange were studied. Detailed studies including kinetic study and regeneration of catalyst were carried out on the optimal conditions for the photodegradation of methyl orange by Au-Zn O multi pods in aqueous solution. Effect of foreign species on the photodegradation of methyl orange was also studied. An enhancement of the photo catalytic activities for photodegradation of methyl orange was observed when the gold nanoparticles were loaded on the zinc oxide multi pods. The proposed catalyst was applied for the degradation of methyl orange in synthetic wastewater samples with satisfactory results.

  9. Pengajaran Tentang Ibadah Berdasarkan Surat Ibrani 10:19-25 Dan Implimentasinya Dalam Kehidupan Orang Percaya Pada Masa Kini

    Directory of Open Access Journals (Sweden)

    Tison Tison

    2013-04-01

    Full Text Available Sesuai dengan permasalahan yang ada, maka tujuan penulisan karya ilmiah iniadalah: Pertama, Untuk menganalisis dan menafsirkan pengajaran tentang ibadahmenurut Ibrani 10:19-25. Kedua, Untuk membahas bagaimana mengimplementasikanpengajaran tentang ibadah dalam kehidupan orang percaya pada masa kini.Dalam penulisan karya ilmiah ini, penulis menggunakan metode penelitiannaskah Alkitab yaitu: Pertama, Metode analisis kitab, dalam hal ini menggunakanmetode penelitian yang mencakup teologi eksegesis dan kajian Alkitab untukmemahami teks yang sesuai dengan konsep yang ada dalam surat Ibrani 10:19-25. Danmenggunakan metode penelitian literatur. Kedua, Komparasi, yaitu mengadakanperbandingan-perbandingan untuk melihat kesamaan atau perbedaan pengajarantentang ibadah.Berdasarkan hasil uraian penulis dalam karya ilmiah mengenai pengajarantentang ibadah berdasarkan surat Ibrani 10:19-25 dan implimentasinya dalamkehidupan orang percaya pada masa kini, maka penulis dapat menarik kesimpulansebagai berikut: Pertama, setiap orang percaya harus mengerti dasar-dasar ibadahorang percaya yaitu darah Yesus yang telah dicurahkan bagi umat manusia yang jugatelah menjadi pengganti korban persembahan untuk datang menghampiri Allah danYesus sebagai Imam Besar. Kedua, dalam ibadah setiap orang percaya harusmemiliki sikap hati yang tulus iklhas, keyakinan iman, hati yang sudah dibasuh danberpegang pada pengakuan pengharapan pada Yesus. Ketiga, dalam ibadah, setiaporang percaya harus memiliki hati yang menyembah karena penyembahan adalah halyang paling utama untuk menyatakan hormat dan tunduk kepada Allah atas karya-Nya bagi hidup orang percaya. Keempat, dalam ibadah, setiap orang percaya harushidup dalam kekudusan, karena dalam kekudusanlah orang percaya layak dihadapanAllah.

  10. A Box-Cox normal model for response times

    NARCIS (Netherlands)

    Klein Entink, R.H.; Fox, J.P.; Linden, W.J. van der

    2009-01-01

    The log-transform has been a convenient choice in response time modelling on test items. However, motivated by a dataset of the Medical College Admission Test where the lognormal model violated the normality assumption, the possibilities of the broader class of Box–Cox transformations for response

  11. Antiinflamatórios não esteróides inibidores da ciclooxigenase-2 (COX-2: aspectos atuais Antiinflamatorios no esteróides inhibidores de la ciclooxigenasa-2 (COX-2: aspectos actuales Cycloxygenase-2 inhibitors nonsteroid anti-inflammatory drugs: current issues

    Directory of Open Access Journals (Sweden)

    Carmen Luize Kummer

    2002-07-01

    Full Text Available JUSTIFICATIVA E OBJETIVOS: Devido à alta incidência de efeitos colaterais relacionados aos antiinflamatórios não hormonais (AINES, a descoberta de duas isoformas da enzima ciclooxigenase, classificadas como: COX-1 ou constitutiva e COX-2 ou indutiva, formulou o paradigma que as propriedades antiinflamatórias dos AINES seriam mediadas através da inibição da enzima COX-2; já os efeitos colaterais, do bloqueio da COX-1. Entretanto, a isoforma COX-2 tem sido detectada constitutivamente em tecidos normais, levantando a dúvida sobre o quão realmente são seguros os inibidores específicos desta enzima. O objetivo desta revisão é relatar as mais recentes evidências clínicas e experimentais envolvendo a COX-2 e os compostos inibidores desta isoforma. CONTEÚDO: São exibidos os novos conceitos sobre as diferenças estruturais entre COX-1 e COX-2, a existência destas isoformas nos diversos tecidos, os resultados de experimentos em animais e humanos, além da observação clínica dos compostos inibidores específicos COX-2 (coxibs. Algumas prováveis novas indicações de antiinflamatórios não esteróides, principalmente coxibs, na demência de Alzheimer e em neoplasias são exemplificadas. CONCLUSÕES: Os coxibs representam importante avanço farmacológico no tratamento antiinflamatório, reduzindo a incidência de lesões gastrointestinais e apresentando possível indicação na prevenção de neoplasias e doenças neurológicas. No entanto, tais compostos apresentam efeitos colaterais indistinguíveis dos AINES convencionais e são drogas de alto custo. Como toda medicação de recente lançamento no arsenal médico, maiores avaliações são necessárias para o estabelecimento da real segurança destes compostos.JUSTIFICATIVA Y OBJETIVOS: Debido a la alta incidencia de efectos colaterales relacionados a los antiinflamatorios no hormonales (AINES, la descubierta de dos isoformas de la enzima ciclooxigenasa, clasificadas como: COX-1

  12. Professionalisme med innovativt potentiale

    DEFF Research Database (Denmark)

    Nielsen, Inger Marie

    To teoretiske sværvægtere bliver koblet sammen i Inger Marie Larsen-Nielsen arbejdspapir om professionalisme med innovativt potentiale. De to teoretikere er læringsteoretikeren John Dewey og socialpsykologen Georg Herbert Mead, som er sat sammen i en teoretisk forståelsesramme omkring professionel...

  13. Agent Orange Exposure and 2,3,7,8-Tetrachlorodibenzo-p-Dioxin (TCDD) in Human Milk.

    Science.gov (United States)

    Scialli, Anthony R; Watkins, Deborah K; Ginevan, Michael E

    2015-06-01

    Agent Orange was sprayed in parts of southern Vietnam during the U.S.-Vietnam war and was a mixture of two chlorophenoxy herbicides. The mixture was contaminated with 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). TCDD and other dioxins and furans are measurable in the milk of Vietnamese women. We explored whether the TCDD in milk from these women was from Agent Orange and whether lactational exposure can be a mode of transgenerational effects of TCDD from Agent Orange. A review of the world's literature on milk concentrations of polychlorinated compounds showed the presence of TCDD and other dioxins and furans in all countries that have been assessed. The congener profile of these chemicals, that is, the proportion of different congeners in the sample, can be used to assess the source of milk contamination. Measurements in most countries, including contemporary measurements in Vietnam, are consistent with non-Agent Orange exposure sources, including industrial activities and incineration of waste. Models and supporting human data suggest that TCDD from breastfeeding does not persist in a child past adolescence and that the adult body burden of TCDD is independent of whether the individual was breast- or bottle-fed as a child. These findings suggest that exposure to Agent Orange in Vietnam did not result in persistent transgenerational exposure through human milk. © 2015 Wiley Periodicals, Inc.

  14. Cyclopamine and jervine induce COX-2 overexpression in human erythroleukemia cells but only cyclopamine has a pro-apoptotic effect

    International Nuclear Information System (INIS)

    Ghezali, Lamia; Leger, David Yannick; Limami, Youness; Cook-Moreau, Jeanne; Beneytout, Jean-Louis; Liagre, Bertrand

    2013-01-01

    Erythroleukemia is generally associated with a very poor response and survival to current available therapeutic agents. Cyclooxygenase-2 (COX-2) has been described to play a crucial role in the proliferation and differentiation of leukemia cells, this enzyme seems to play an important role in chemoresistance in different cancer types. Previously, we demonstrated that diosgenin, a plant steroid, induced apoptosis in HEL cells with concomitant COX-2 overexpression. In this study, we investigated the antiproliferative and apoptotic effects of cyclopamine and jervine, two steroidal alkaloids with similar structures, on HEL and TF1a human erythroleukemia cell lines and, for the first time, their effect on COX-2 expression. Cyclopamine, but not jervine, inhibited cell proliferation and induced apoptosis in these cells. Both compounds induced COX-2 overexpression which was responsible for apoptosis resistance. In jervine-treated cells, COX-2 overexpression was NF-κB dependent. Inhibition of NF-κB reduced COX-2 overexpression and induced apoptosis. In addition, cyclopamine induced apoptosis and COX-2 overexpression via PKC activation. Inhibition of the PKC pathway reduced both apoptosis and COX-2 overexpression in both cell lines. Furthermore, we demonstrated that the p38/COX-2 pathway was involved in resistance to cyclopamine-induced apoptosis since p38 inhibition reduced COX-2 overexpression and increased apoptosis in both cell lines. - Highlights: ► Cyclopamine alone but not jervine induces apoptosis in human erythroleukemia cells. ► Cyclopamine and jervine induce COX-2 overexpression. ► COX-2 overexpression is implicated in resistance to cyclopamine-induced apoptosis. ► Apoptotic potential of jervine is restrained by NF-κB pathway activation. ► PKC is involved in cyclopamine-induced apoptosis and COX-2 overexpression

  15. Cyclopamine and jervine induce COX-2 overexpression in human erythroleukemia cells but only cyclopamine has a pro-apoptotic effect

    Energy Technology Data Exchange (ETDEWEB)

    Ghezali, Lamia; Leger, David Yannick; Limami, Youness [Université de Limoges, FR 3503 GEIST, EA 1069 “Laboratoire de Chimie des Substances Naturelles”, GDR CNRS 3049, Faculté de Pharmacie, Laboratoire de Biochimie et Biologie Moléculaire, 2 rue du Docteur Marcland, 87025 Limoges Cedex (France); Cook-Moreau, Jeanne [Université de Limoges, FR 3503 GEIST, UMR CNRS 7276 “Contrôle de la réponse immune B et lymphoproliférations”, Faculté de Médecine, 2 rue du Docteur Marcland, 87025 Limoges Cedex (France); Beneytout, Jean-Louis [Université de Limoges, FR 3503 GEIST, EA 1069 “Laboratoire de Chimie des Substances Naturelles”, GDR CNRS 3049, Faculté de Pharmacie, Laboratoire de Biochimie et Biologie Moléculaire, 2 rue du Docteur Marcland, 87025 Limoges Cedex (France); Liagre, Bertrand, E-mail: bertrand.liagre@unilim.fr [Université de Limoges, FR 3503 GEIST, EA 1069 “Laboratoire de Chimie des Substances Naturelles”, GDR CNRS 3049, Faculté de Pharmacie, Laboratoire de Biochimie et Biologie Moléculaire, 2 rue du Docteur Marcland, 87025 Limoges Cedex (France)

    2013-04-15

    Erythroleukemia is generally associated with a very poor response and survival to current available therapeutic agents. Cyclooxygenase-2 (COX-2) has been described to play a crucial role in the proliferation and differentiation of leukemia cells, this enzyme seems to play an important role in chemoresistance in different cancer types. Previously, we demonstrated that diosgenin, a plant steroid, induced apoptosis in HEL cells with concomitant COX-2 overexpression. In this study, we investigated the antiproliferative and apoptotic effects of cyclopamine and jervine, two steroidal alkaloids with similar structures, on HEL and TF1a human erythroleukemia cell lines and, for the first time, their effect on COX-2 expression. Cyclopamine, but not jervine, inhibited cell proliferation and induced apoptosis in these cells. Both compounds induced COX-2 overexpression which was responsible for apoptosis resistance. In jervine-treated cells, COX-2 overexpression was NF-κB dependent. Inhibition of NF-κB reduced COX-2 overexpression and induced apoptosis. In addition, cyclopamine induced apoptosis and COX-2 overexpression via PKC activation. Inhibition of the PKC pathway reduced both apoptosis and COX-2 overexpression in both cell lines. Furthermore, we demonstrated that the p38/COX-2 pathway was involved in resistance to cyclopamine-induced apoptosis since p38 inhibition reduced COX-2 overexpression and increased apoptosis in both cell lines. - Highlights: ► Cyclopamine alone but not jervine induces apoptosis in human erythroleukemia cells. ► Cyclopamine and jervine induce COX-2 overexpression. ► COX-2 overexpression is implicated in resistance to cyclopamine-induced apoptosis. ► Apoptotic potential of jervine is restrained by NF-κB pathway activation. ► PKC is involved in cyclopamine-induced apoptosis and COX-2 overexpression.

  16. Involvement of COX2–thromboxane pathway in TCDD-induced precardiac edema in developing zebrafish

    International Nuclear Information System (INIS)

    Teraoka, Hiroki; Okuno, Yuki; Nijoukubo, Daisuke; Yamakoshi, Ayumi; Peterson, Richard E.; Stegeman, John J.; Kitazawa, Takio; Hiraga, Takeo; Kubota, Akira

    2014-01-01

    Highlights: • We establish a new indicator of pericardial edema in developing zebrafish (precardiac edema). • Property of precardiac edema by TCDD is similar to that for conventional pericardial edema. • COX2b (but not COX2a)–thromboxane pathway is involved in precardiac edema by TCDD. - Abstract: The cardiovascular system is one of the most characteristic and important targets for developmental toxicity by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in fish larvae. However, knowledge of the mechanism of TCDD-induced edema after heterodimerization of aryl hydrocarbon receptor type 2 (AHR2) and AHR nuclear translocator type 1 (ARNT1) is still limited. In the present study, microscopic analysis with a high-speed camera revealed that TCDD increased the size of a small cavity between the heart and body wall in early eleutheroembryos, a toxic effect that we designate as precardiac edema. A concentration–response curve for precardiac edema at 2 days post fertilization (dpf) showed close similarity to that for conventional pericardial edema at 3 dpf. Precardiac edema caused by TCDD was reduced by morpholino knockdown of AHR2 and ARNT1, as well as by an antioxidant (ascorbic acid). A selective inhibitor of cyclooxygenase type 2 (COX2), NS398, also markedly inhibited TCDD-induced precardiac edema. A thromboxane receptor (TP) antagonist, ICI-192,605 almost abolished TCDD-induced precardiac edema and this effect was canceled by U46619, a TP agonist, which was not influential in the action of TCDD by itself. Knockdown of COX2b and thromboxane A synthase 1 (TBXS), but not COX2a, strongly reduced TCDD-induced precardiac edema. Knockdown of COX2b was without effect on mesencephalic circulation failure caused by TCDD. The edema by TCDD was also inhibited by knockdown of c-mpl, a thrombopoietin receptor necessary for thromobocyte production. Finally, induction of COX2b, but not COX2a, by TCDD was seen in eleutheroembryos at 3 dpf. These results suggest a role of the COX2b

  17. Involvement of COX2–thromboxane pathway in TCDD-induced precardiac edema in developing zebrafish

    Energy Technology Data Exchange (ETDEWEB)

    Teraoka, Hiroki, E-mail: hteraoka@rakuno.ac.jp [School of Veterinary Medicine, Rakuno Gakuen University, Ebetsu (Japan); Okuno, Yuki; Nijoukubo, Daisuke; Yamakoshi, Ayumi [School of Veterinary Medicine, Rakuno Gakuen University, Ebetsu (Japan); Peterson, Richard E. [School of Pharmacy, University of Wisconsin, Madison, WI (United States); Stegeman, John J. [Biology Department, Woods Hole Oceanographic Institution, Woods Hole, MA (United States); Kitazawa, Takio; Hiraga, Takeo [School of Veterinary Medicine, Rakuno Gakuen University, Ebetsu (Japan); Kubota, Akira [School of Veterinary Medicine, Rakuno Gakuen University, Ebetsu (Japan); Biology Department, Woods Hole Oceanographic Institution, Woods Hole, MA (United States)

    2014-09-15

    Highlights: • We establish a new indicator of pericardial edema in developing zebrafish (precardiac edema). • Property of precardiac edema by TCDD is similar to that for conventional pericardial edema. • COX2b (but not COX2a)–thromboxane pathway is involved in precardiac edema by TCDD. - Abstract: The cardiovascular system is one of the most characteristic and important targets for developmental toxicity by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in fish larvae. However, knowledge of the mechanism of TCDD-induced edema after heterodimerization of aryl hydrocarbon receptor type 2 (AHR2) and AHR nuclear translocator type 1 (ARNT1) is still limited. In the present study, microscopic analysis with a high-speed camera revealed that TCDD increased the size of a small cavity between the heart and body wall in early eleutheroembryos, a toxic effect that we designate as precardiac edema. A concentration–response curve for precardiac edema at 2 days post fertilization (dpf) showed close similarity to that for conventional pericardial edema at 3 dpf. Precardiac edema caused by TCDD was reduced by morpholino knockdown of AHR2 and ARNT1, as well as by an antioxidant (ascorbic acid). A selective inhibitor of cyclooxygenase type 2 (COX2), NS398, also markedly inhibited TCDD-induced precardiac edema. A thromboxane receptor (TP) antagonist, ICI-192,605 almost abolished TCDD-induced precardiac edema and this effect was canceled by U46619, a TP agonist, which was not influential in the action of TCDD by itself. Knockdown of COX2b and thromboxane A synthase 1 (TBXS), but not COX2a, strongly reduced TCDD-induced precardiac edema. Knockdown of COX2b was without effect on mesencephalic circulation failure caused by TCDD. The edema by TCDD was also inhibited by knockdown of c-mpl, a thrombopoietin receptor necessary for thromobocyte production. Finally, induction of COX2b, but not COX2a, by TCDD was seen in eleutheroembryos at 3 dpf. These results suggest a role of the COX2b

  18. Beta-spectrometer with magnetic filter of mini orange type

    International Nuclear Information System (INIS)

    Gorozhankin, V.M.; Gromov, K.Ya.; Kalinnikov, V.G.; Sereeter, Z.; Fominykh, V.I.; Malikov, Sh.R.; Yuldashev, M.B.

    1997-01-01

    At the ISOL facility YASNAPP-2 a β-spectrometer with a magnetic filter of the miniorange type is constructed to measure γ-ray internal conversion coefficients. The magnetic filter of the mini orange type is an assemblage of permanent magnets creating a toroidal magnetic field perpendicular to the electron trajectories from the source to the Si(Li) detector. The chosen profile of the permanent magnets allowed electron registration in the defined energy energy interval with some transmission increase. There are two sets of permanent magnets of the different thickness. Varying the type and number of permanent magnets one can set the detected electron energy intervals in a 50-2500 keV range. The efficiency of the spectrometer was investigated for different assemblages of the mini orange magnet. The facility can be used for the e-γ coincidence investigation. (A.A.D.)

  19. The Doppler paradigm and the APEX-EPOS-ORANGE quandary

    International Nuclear Information System (INIS)

    Griffin, J.J.

    1995-01-01

    The experimental detection of the sharp lines of the (e + e - ) Puzzle is viewed as a struggle against Doppler broadening. Gedanken experiments which are realistic in zeroth order of detail are analyzed to show that the ORANGE and EPOS/I geometries select narrower slices of a Doppler broadened line than spherically inclusive (APEX and EPOS/II -like) apparati. Roughly speaking, the latter require event-by-event Doppler reconstruction simply to regain an even footing with the former. This suggests that APEX' or EPOS/II's coincident pair distributions must be statistically superior to those of EPOS/I or ORANGE in order to support a comparable inference about sharp structure. Under such circumstances, independent alternative data is invaluable. Therefore, a corroboration of Sakai's 330.1 keV ( + or e - bombardments of U and Th targets could prove crucial

  20. Effects of Lactobacillus plantarum and hydrolytic enzymes on fermentation and ruminal degradability of orange pulp silage

    DEFF Research Database (Denmark)

    Taghizadeh, Akbar; Paya, Hamid; Lashkari, Saman

    2015-01-01

    The current study was carried out to examine the effect of inoculants, enzymes and mixtures of them on the fermentation, degradability and nutrient value of orange pulp silage. Orange pulp was treated with water (control), inoculant (Lactobacillus plantarum), enzymes (multiple enzyme) or inoculants...