Musikterapi med børn med svær autisme - en litteraturgennemgang

Directory of Open Access Journals (Sweden)

Ulla Holck

2003-03-01

Full Text Available Faglitteratur om musikterapi med børn med autisme er omfattende og indeholder såvel kvalitative case-beskrivelser som kvantitative forskningsundersøgelser. I artiklen gennemgås faglitteraturen systematisk med henblik på at specifi cere musikterapiens effekt og virkemåder i forhold til denne målgruppe. Vægten ligger på børn med svær autisme, men litteratur om voksne højtfungerende personer med autisme inddrages også. Forskningslitteraturen viser, at det især er inden for områderne koncentration, visuel opmærksomhed, respons og initiativ, samt brug af stemme og tur-tagning, at musikterapi har en effekt. Case-litteraturen begrunder denne effekt med musikkens evne til at være redundant, anvendelse af imitation og responsfremmende teknikker (overraskelse etc., fælles opbyggede samspilsformer, samt det temporale-interaktive element i improvisatorisk musikterapi. Ud fra en interaktionsteoretisk indfaldsvinkel sammenkobles effekten endvidere med, at den musikalske interaktion hjælper musikterapeuten til at fastholde et dynamisk udtryk, hvilket er afgørende i forhold til en klientgruppe, der ofte giver ´flad´ eller stærkt afvigende feedback.

Nostalgitrip med Pikachu

DEFF Research Database (Denmark)

Konzack, Lars

2016-01-01

Sommeren 2016 vil blive husket for den omsiggribende dille, Pokémon Go, med over 100 millioner downloads. Tusindvis af især børn og unge, men også forældre med barnevogne og hele familier, kunne pludselig ses på gader og stræder, i parker og grønne områder med en smartphone i hånden på jagt efter...

Interview med børn

DEFF Research Database (Denmark)

Interview med børn handler om børneinterview i forbindelse med forskning. Bogen er tænkt som inspiration til og afsæt for metodiske refleksioner i forbindelse med inddragelse af børn som informanter.......Interview med børn handler om børneinterview i forbindelse med forskning. Bogen er tænkt som inspiration til og afsæt for metodiske refleksioner i forbindelse med inddragelse af børn som informanter....

Virtuelt skrivebord med open office

DEFF Research Database (Denmark)

Nielsen, Kurt Gammelgaard

2009-01-01

SDUs erfaringer med projektet Port 22: en virtuel platform med Open Office som kontorpakke til studerende.......SDUs erfaringer med projektet Port 22: en virtuel platform med Open Office som kontorpakke til studerende....

Mediator Complex Subunits MED2, MED5, MED16, and MED23 Genetically Interact in the Regulation of Phenylpropanoid Biosynthesis.

Science.gov (United States)

Dolan, Whitney L; Dilkes, Brian P; Stout, Jake M; Bonawitz, Nicholas D; Chapple, Clint

2017-12-01

The phenylpropanoid pathway is a major global carbon sink and is important for plant fitness and the engineering of bioenergy feedstocks. In Arabidopsis thaliana , disruption of two subunits of the transcriptional regulatory Mediator complex, MED5a and MED5b, results in an increase in phenylpropanoid accumulation. By contrast, the semidominant MED5b mutation reduced epidermal fluorescence4-3 ( ref4-3 ) results in dwarfism and constitutively repressed phenylpropanoid accumulation. Here, we report the results of a forward genetic screen for suppressors of ref4-3. We identified 13 independent lines that restore growth and/or phenylpropanoid accumulation in the ref4-3 background. Two of the suppressors restore growth without restoring soluble phenylpropanoid accumulation, indicating that the growth and metabolic phenotypes of the ref4-3 mutant can be genetically disentangled. Whole-genome sequencing revealed that all but one of the suppressors carry mutations in MED5b or other Mediator subunits. RNA-seq analysis showed that the ref4-3 mutation causes widespread changes in gene expression, including the upregulation of negative regulators of the phenylpropanoid pathway, and that the suppressors reverse many of these changes. Together, our data highlight the interdependence of individual Mediator subunits and provide greater insight into the transcriptional regulation of phenylpropanoid biosynthesis by the Mediator complex. © 2017 American Society of Plant Biologists. All rights reserved.

MedSun Reports

Data.gov (United States)

U.S. Department of Health & Human Services — The Medical Product Safety Network (MedSun) is an adverse event reporting program launched in 2002. The primary goal for MedSun is to work collaboratively with the...

The MedDRA paradox.

Science.gov (United States)

Merrill, Gary H

2008-11-06

MedDRA (the Medical Dictionary for Regulatory Activities Terminology) is a controlled vocabulary widely used as a medical coding scheme. However, MedDRA's characterization of its structural hierarchy exhibits some confusing and paradoxical features. The goal of this paper is to examine these features, determine whether there is a coherent view of the MedDRA hierarchy that emerges, and explore what lessons are to be learned from this for using MedDRA and similar terminologies in a broad medical informatics context that includes relations among multiple disparate terminologies, thesauri, and ontologies.

Humant papillomavirus i orale lidelser med malignt potentiale

DEFF Research Database (Denmark)

Bjørlig, Xenia; Waage Brinch, Arendse; Kongsmark Madsen, Jonas

2016-01-01

– At belyse prævalensen af HPV i OLMP og diskutere betydningen af HPV for malign udvikling af disse forandringer. Materiale og metode – På baggrund af litteratursøgning beskrives, hvordan HPV associeres til OLMP, herunder specifikt leukoplaki, erytroplaki og oral lichen planus samt forekomsten af HPV i sund......Introduktion – Humant papillomavirus (HPV) er i dag anerkendt som den vigtigste enkelte ætiologiske faktor til cervixcancer, og det er nu blevet klart, at der også findes en sammenhæng mellem HPV og undergrupper af hoved-halscancer. Sammenhængen mellem HPV og en andel af orale cancere er også...... undersøgt, særligt grundet den stigende incidens af oral cancer på trods af et fald og en stagnering i forbruget af risikofaktorer som tobak og alkohol. Tandlægen ser ofte orale lidelser med malignt potentiale (OLMP) i mundslimhinden, og mellem 20-50 % af orale cancere menes at forudgås af OLMP. Formål...

MedAustron – Non-Clinical Research Opportunities

International Nuclear Information System (INIS)

Schreiner, T.

2013-01-01

MedAustron is a synchrotron based light-ion beam therapy centre for cancer treatment as well as for clinical and non-clinical research, currently in the construction phase in Wiener Neustadt. Whilst the choice of basic machine parameters was driven by medical requirements, the accelerator complex design was also optimised to offer flexibility for research operation. The potential of the synchrotron is being exploited to increase the maximum proton energy far beyond the medical needs to up to 800 MeV, for experimental physics applications, mainly in the areas of proton scattering and detector research. The accelerator layout allows for the installation of up to four ion source-spectrometer units, to provide various ion types besides the clinical used protons and carbon ions. To decouple research and medical operation, a dedicated irradiation room for non-clinical research was included providing two isocentres for the installation of different experiments. This presentation provides a status overview over the whole project and highlights the non-clinical research opportunities at MedAustron. (author)

Analysis of PubMed User Sessions Using a Full-Day PubMed Query Log: A Comparison of Experienced and Nonexperienced PubMed Users

Science.gov (United States)

2015-01-01

Background PubMed is the largest biomedical bibliographic information source on the Internet. PubMed has been considered one of the most important and reliable sources of up-to-date health care evidence. Previous studies examined the effects of domain expertise/knowledge on search performance using PubMed. However, very little is known about PubMed users’ knowledge of information retrieval (IR) functions and their usage in query formulation. Objective The purpose of this study was to shed light on how experienced/nonexperienced PubMed users perform their search queries by analyzing a full-day query log. Our hypotheses were that (1) experienced PubMed users who use system functions quickly retrieve relevant documents and (2) nonexperienced PubMed users who do not use them have longer search sessions than experienced users. Methods To test these hypotheses, we analyzed PubMed query log data containing nearly 3 million queries. User sessions were divided into two categories: experienced and nonexperienced. We compared experienced and nonexperienced users per number of sessions, and experienced and nonexperienced user sessions per session length, with a focus on how fast they completed their sessions. Results To test our hypotheses, we measured how successful information retrieval was (at retrieving relevant documents), represented as the decrease rates of experienced and nonexperienced users from a session length of 1 to 2, 3, 4, and 5. The decrease rate (from a session length of 1 to 2) of the experienced users was significantly larger than that of the nonexperienced groups. Conclusions Experienced PubMed users retrieve relevant documents more quickly than nonexperienced PubMed users in terms of session length. PMID:26139516

Evaluering af ordning med psykologbehandling af personer med let til moderat depression

DEFF Research Database (Denmark)

Fjeldsted, Rita; Christensen, Kaj Sparle

Herværende rapport evaluerer den pr. 1.4.2008 indførte ordning med mulighed for henvisning til psykologbehandling med 60 % tilskud for patienter med let til moderat depression. Evalueringen har betjent sig af flere gensidigt supplerende metoder: spørgeskemaundersøgelser overfor patienter, psykolo......Herværende rapport evaluerer den pr. 1.4.2008 indførte ordning med mulighed for henvisning til psykologbehandling med 60 % tilskud for patienter med let til moderat depression. Evalueringen har betjent sig af flere gensidigt supplerende metoder: spørgeskemaundersøgelser overfor patienter...... tidligere evaluering af forsøgsordning af psykologbehandling af depression i perioden 2005-06. 18.419 personer i alderen 18-37 år blev henvist til psykolog i den undersøgte ordning i perioden 1.2.2009 – 31.1.2010, svarende til en henvisningshyppighed på 1,6 % af baggrundsbefolkningen i samme aldersgruppe....... Ordningen giver mulighed for én rehenvisning, og 9 % blev rehenvist i perioden. Spørgeskemaresultater viser, at kun 33 % af de henviste falder ind under henvisningskriteriet ” let til moderat depression” på tidspunktet for opstart af psykologbehandling, 39 % har ingen tegn på depression, og 28 % har svær...

Cancer in Children and Adolescents

Science.gov (United States)

... mortality among 5-year survivors of childhood cancer. New England Journal of Medicine 2016; 374(9):833-842. [PubMed Abstract] Oeffinger ... health conditions in adult survivors of childhood cancer. New England Journal of Medicine 2006; 355(15):1572-1582. [PubMed Abstract] Meadows ...

Depletion of Mediator Kinase Module Subunits Represses Superenhancer-Associated Genes in Colon Cancer Cells.

Science.gov (United States)

Kuuluvainen, Emilia; Domènech-Moreno, Eva; Niemelä, Elina H; Mäkelä, Tomi P

2018-06-01

In cancer, oncogene activation is partly mediated by acquired superenhancers, which therefore represent potential targets for inhibition. Superenhancers are enriched for BRD4 and Mediator, and both BRD4 and the Mediator MED12 subunit are disproportionally required for expression of superenhancer-associated genes in stem cells. Here we show that depletion of Mediator kinase module subunit MED12 or MED13 together with MED13L can be used to reduce expression of cancer-acquired superenhancer genes, such as the MYC gene, in colon cancer cells, with a concomitant decrease in proliferation. Whereas depletion of MED12 or MED13/MED13L caused a disproportional decrease of superenhancer gene expression, this was not seen with depletion of the kinases cyclin-dependent kinase 9 (CDK8) and CDK19. MED12-MED13/MED13L-dependent superenhancer genes were coregulated by β-catenin, which has previously been shown to associate with MED12. Importantly, β-catenin depletion caused reduced binding of MED12 at the MYC superenhancer. The effect of MED12 or MED13/MED13L depletion on cancer-acquired superenhancer gene expression was more specific than and partially distinct from that of BRD4 depletion, with the most efficient inhibition seen with combined targeting. These results identify a requirement of MED12 and MED13/MED13L for expression of acquired superenhancer genes in colon cancer, implicating these Mediator subunits as potential therapeutic targets for colon cancer, alone or together with BRD4. Copyright © 2018 American Society for Microbiology.

Calculation of Metallization Resistivity and Thickness for MedAustron Kickers

CERN Document Server

Barnes, M J; Stadlbauer, T

2011-01-01

The MedAustron facility, to be built in Wiener Neustadt (Austria), will provide protons and ions for both cancer therapy and research [1]. Different types of kicker magnets will be used in the facility. The kicker magnets are outside machine vacuum: each kicker magnet has a ceramic beam chamber whose inner surface is metalized. The resistivity and thickness of the metallization are chosen such that the induced eddy currents, resulting from the pulsed kicker magnetic field, do not unduly affect the rise/fall times or homogeneity of the magnetic field. A comparison of an analytical calculation and measurement is reported for the effect of metallization of a ceramic chamber in an existing kicker system at CERN. Conclusions concerning the metallization of the ceramic chambers for the MedAustron kicker magnets are presented.

Sammensvorne designere med succes

DEFF Research Database (Denmark)

Dickson, Thomas

2005-01-01

Den danske tegnestue Komplot Design har for nylig oplevet den ære, at to af deres stole bliver brugt i cafeerne på det nyindrettede Museum of Modern Art i New York. Men det er ikke kun med møbler, de har succes - tegnestuen kaster sig med iver over mange slags produkter.......Den danske tegnestue Komplot Design har for nylig oplevet den ære, at to af deres stole bliver brugt i cafeerne på det nyindrettede Museum of Modern Art i New York. Men det er ikke kun med møbler, de har succes - tegnestuen kaster sig med iver over mange slags produkter....

Processeringsoptimering med Canons software

DEFF Research Database (Denmark)

Precht, Helle

2009-01-01

. Muligheder i software optimering blev studeret i relation til optimal billedkvalitet og kontrol optagelser, for at undersøge om det var muligt at acceptere diagnostisk billedkvalitet og derved tage afsæt i ALARA. Metode og materialer Et kvantitativt eksperimentelt studie baseret på forsøg med teknisk og...... humant fantom. CD Rad fantom anvendes som teknisk fantom, hvor billederne blev analyseret med CD Rad software, og resultatet var en objektiv IQF værdi. Det humane fantom var et lamme pelvis med femur, der via NRPB’ er sammenlignelig med absorptionen ved et femårigt barn. De humane forsøgsbilleder blev...

PubMed-EX: a web browser extension to enhance PubMed search with text mining features.

Science.gov (United States)

Tsai, Richard Tzong-Han; Dai, Hong-Jie; Lai, Po-Ting; Huang, Chi-Hsin

2009-11-15

PubMed-EX is a browser extension that marks up PubMed search results with additional text-mining information. PubMed-EX's page mark-up, which includes section categorization and gene/disease and relation mark-up, can help researchers to quickly focus on key terms and provide additional information on them. All text processing is performed server-side, freeing up user resources. PubMed-EX is freely available at http://bws.iis.sinica.edu.tw/PubMed-EX and http://iisr.cse.yzu.edu.tw:8000/PubMed-EX/.

Ulykke med hækkesaks

DEFF Research Database (Denmark)

Leth, Peter Mygind

1996-01-01

Snitsår med blødning fra en overskåret pulsåre på armen forekommer hyppigt ved selvmordsforsøg, men har sjældent et dødeligt forløb. Her gives et eksempel på en isoleret partiel overklipning af a.ulnaris ved en ulykke med en hækkesaks med dødelig forløbende blødning.......Snitsår med blødning fra en overskåret pulsåre på armen forekommer hyppigt ved selvmordsforsøg, men har sjældent et dødeligt forløb. Her gives et eksempel på en isoleret partiel overklipning af a.ulnaris ved en ulykke med en hækkesaks med dødelig forløbende blødning....

Relevansen af nyere psykodynamisk teori for det klinisk musikterapeutiske arbejde med psykiatriske patienter med personlighedsforstyrrelser

DEFF Research Database (Denmark)

Hannibal, Niels

2007-01-01

Denne artikel beskriver et rationale for anvendelse af musik i en psykoterapeutisk kontekst. Det eksplicitte og implicitte forandringsniveau i psykoterapi med patienter med borderline-personlighedsforstyrrelse (BPF) diskuteres herpå med henvisning til to forskellige syn på terapeutisk forandring:...

Gruppemusikterapi med patienter med borderline-personlighedsforstyrrelse i dagbehandlingsregi

Directory of Open Access Journals (Sweden)

Niels Hannibal

2008-05-01

Full Text Available Denne artikel er første redegørelse for de erfaringer, som er gjort med gruppemusikterapi (GMT for patienter med borderline-personlighedsforstyrrelse (BPF i dagbehandlingsregi på Aalborg Psykiatriske Sygehus. Artiklen indeholder både konkrete anvisninger til aktiviteter og interventioner, ligesom den i et teoretisk perspektiv redegør for forskellige processer og reaktioner, der kan iagttages i behandlingen. Artiklen konkluderer, at GMT i sin nuværende form kan bidrage til udvikling af BPF-patienters evne til mentalisering og affektregulering, til opbygning af en gruppefølelse og fremme af interpersonel læring, ligesom GMT kan udvikle alliance til terapi generelt og GMT specifikt.

MedPAC Data Book

Data.gov (United States)

U.S. Department of Health & Human Services — MedPACs Data Book is the result of discussions with congressional staff members regarding ways that MedPAC can better support them. Some of the information it...

The MEDIATOR genes MED12 and MED13 control Arabidopsis root system configuration influencing sugar and auxin responses.

Science.gov (United States)

Raya-González, Javier; López-Bucio, Jesús Salvador; Prado-Rodríguez, José Carlos; Ruiz-Herrera, León Francisco; Guevara-García, Ángel Arturo; López-Bucio, José

2017-09-01

Arabidopsis med12 and med13 mutants exhibit shoot and root phenotypes related to an altered auxin homeostasis. Sucrose supplementation reactivates both cell division and elongation in primary roots as well as auxin-responsive and stem cell niche gene expression in these mutants. An analysis of primary root growth of WT, med12, aux1-7 and med12 aux1 single and double mutants in response to sucrose and/or N-1-naphthylphthalamic acid (NPA) placed MED12 upstream of auxin transport for the sugar modulation of root growth. The MEDIATOR (MED) complex plays diverse functions in plant development, hormone signaling and biotic and abiotic stress tolerance through coordination of transcription. Here, we performed genetic, developmental, molecular and pharmacological analyses to characterize the role of MED12 and MED13 on the configuration of root architecture and its relationship with auxin and sugar responses. Arabidopsis med12 and med13 single mutants exhibit shoot and root phenotypes consistent with altered auxin homeostasis including altered primary root growth, lateral root development, and root hair elongation. MED12 and MED13 were required for activation of cell division and elongation in primary roots, as well as auxin-responsive and stem cell niche gene expression. Remarkably, most of these mutant phenotypes were rescued by supplying sucrose to the growth medium. The growth response of primary roots of WT, med12, aux1-7 and med12 aux1 single and double mutants to sucrose and application of auxin transport inhibitor N-1-naphthylphthalamic acid (NPA) revealed the correlation of med12 phenotype with the activity of the auxin intake permease and suggests that MED12 acts upstream of AUX1 in the root growth response to sugar. These data provide compelling evidence that MEDIATOR links sugar sensing to auxin transport and distribution during root morphogenesis.

Leg med vision

DEFF Research Database (Denmark)

Munk, Mette; Bertelsen, Katrine

2011-01-01

Bogen henvender sig primært til det pædagogiske personale med målgruppen daginstitutioner. Bogen skal stimulere arbejdet med at gøre bevægelse til en integreret del af kulturen i daginstitutioner - at få det pædagogiske personale til - at sætte ord på og spørgsmålstegn ved deres pædagogiske bevæg...

Lærere arbejder med landskabsdannelse

DEFF Research Database (Denmark)

2012-01-01

Valg af materiale/medie/form: YOUtube videoklip. Valg af arbejdsform: Lærere der er igang med at afprøve praktisk undersøgende arbejde med danske landskabsformer. Begrundelse for valg af materiale/medie/form/arbejdsform: Ultrakort videoklip valgt så 1) lærerne kan dele med kolleger, 2) øvrige...

MED12 exon 2 mutations in phyllodes tumors of the breast

International Nuclear Information System (INIS)

Nagasawa, Satoi; Maeda, Ichiro; Fukuda, Takayo; Wu, Wenwen; Hayami, Ryosuke; Kojima, Yasuyuki; Tsugawa, Ko-ichiro; Ohta, Tomohiko

2015-01-01

Exon 2 of MED12, a subunit of the transcriptional mediator complex, has been frequently mutated in uterine leiomyomas and breast fibroadenomas; however, it has been rarely mutated in other tumors. Although the mutations were also found in uterine leiomyosarcomas, the frequency was significantly lower than in uterine leiomyomas. Here, we examined the MED12 mutation in phyllodes tumors, another biphasic tumor with epithelial and stromal components related to breast fibroadenomas. Mutations in MED12 exon 2 were analyzed in nine fibroadenomas and eleven phyllodes tumors via Sanger sequencing. A panel of cancer- and sarcoma-related genes was also analyzed using Ion Torrent next-generation sequencing. Six mutations in fibroadenomas, including those previously reported (6/9, 67%), and five mutations in phyllodes tumors (5/11, 45%) were observed. Three mutations in the phyllodes tumors were missense mutations at Gly44, which is common in uterine leiomyomas and breast fibroadenomas. In addition, two deletion mutations (in-frame c.133-144del12 and loss of splice acceptor c.100-68-137del106) were observed in the phyllodes tumors. No other recurrent mutation was observed with next-generation sequencing. Frequent mutations in MED12 exon 2 in the phyllodes tumors suggest that it may share genetic etiology with uterine leiomyoma, a subgroup of uterine leiomyosarcomas and breast fibroadenoma

Med Kingo på dybt vand

DEFF Research Database (Denmark)

Arndal, Lars Stubbe

2014-01-01

Tag med digteren Thomas Kingo ud på dybt vand i selskab med lektor og mag.art. Lars Arndal, der kaster nye perspektiver på Kingos forlisdigt Hierte-Suk. Arndal kommer hermed også med et bud på, hvordan man som lærer kan invitere eleverne med på opdagelse i digtet...

Comprehensive analysis of the transcriptional profile of the Mediator complex across human cancer types.

Science.gov (United States)

Syring, Isabella; Klümper, Niklas; Offermann, Anne; Braun, Martin; Deng, Mario; Boehm, Diana; Queisser, Angela; von Mässenhausen, Anne; Brägelmann, Johannes; Vogel, Wenzel; Schmidt, Doris; Majores, Michael; Schindler, Anne; Kristiansen, Glen; Müller, Stefan C; Ellinger, Jörg; Shaikhibrahim, Zaki; Perner, Sven

2016-04-26

The Mediator complex is a key regulator of gene transcription and several studies demonstrated altered expressions of particular subunits in diverse human diseases, especially cancer. However a systematic study deciphering the transcriptional expression of the Mediator across different cancer entities is still lacking.We therefore performed a comprehensive in silico cancer vs. benign analysis of the Mediator complex subunits (MEDs) for 20 tumor entities using Oncomine datasets. The transcriptional expression profiles across almost all cancer entities showed differentially expressed MEDs as compared to benign tissue. Differential expression of MED8 in renal cell carcinoma (RCC) and MED12 in lung cancer (LCa) were validated and further investigated by immunohistochemical staining on tissue microarrays containing large numbers of specimen. MED8 in clear cell RCC (ccRCC) associated with shorter survival and advanced TNM stage and showed higher expression in metastatic than primary tumors. In vitro, siRNA mediated MED8 knockdown significantly impaired proliferation and motility in ccRCC cell lines, hinting at a role for MED8 to serve as a novel therapeutic target in ccRCC. Taken together, our Mediator complex transcriptome proved to be a valid tool for identifying cancer-related shifts in Mediator complex composition, revealing that MEDs do exhibit cancer specific transcriptional expression profiles.

OpenGeneMed: a portable, flexible and customizable informatics hub for the coordination of next-generation sequencing studies in support of precision medicine trials.

Science.gov (United States)

Palmisano, Alida; Zhao, Yingdong; Li, Ming-Chung; Polley, Eric C; Simon, Richard M

2017-09-01

Trials involving genomic-driven treatment selection require the coordination of many teams interacting with a great variety of information. The need of better informatics support to manage this complex set of operations motivated the creation of OpenGeneMed. OpenGeneMed is a stand-alone and customizable version of GeneMed (Zhao et al. GeneMed: an informatics hub for the coordination of next-generation sequencing studies that support precision oncology clinical trials. Cancer Inform 2015;14(Suppl 2):45), a web-based interface developed for the National Cancer Institute Molecular Profiling-based Assignment of Cancer Therapy (NCI-MPACT) clinical trial coordinated by the NIH. OpenGeneMed streamlines clinical trial management and it can be used by clinicians, lab personnel, statisticians and researchers as a communication hub. It automates the annotation of genomic variants identified by sequencing tumor DNA, classifies the actionable mutations according to customizable rules and facilitates quality control in reviewing variants. The system generates summarized reports with detected genomic alterations that a treatment review team can use for treatment assignment. OpenGeneMed allows collaboration to happen seamlessly along the clinical pipeline; it helps reduce errors made transferring data between groups and facilitates clear documentation along the pipeline. OpenGeneMed is distributed as a stand-alone virtual machine, ready for deployment and use from a web browser; its code is customizable to address specific needs of different clinical trials and research teams. Examples on how to change the code are provided in the technical documentation distributed with the virtual machine. In summary, OpenGeneMed offers an initial set of features inspired by our experience with GeneMed, a system that has been proven to be efficient and successful for coordinating the application of next-generation sequencing in the NCI-MPACT trial. Published by Oxford University Press 2016. This

Characterization of the mechanism of drug-drug interactions from PubMed using MeSH terms.

Science.gov (United States)

Lu, Yin; Figler, Bryan; Huang, Hong; Tu, Yi-Cheng; Wang, Ju; Cheng, Feng

2017-01-01

Identifying drug-drug interaction (DDI) is an important topic for the development of safe pharmaceutical drugs and for the optimization of multidrug regimens for complex diseases such as cancer and HIV. There have been about 150,000 publications on DDIs in PubMed, which is a great resource for DDI studies. In this paper, we introduced an automatic computational method for the systematic analysis of the mechanism of DDIs using MeSH (Medical Subject Headings) terms from PubMed literature. MeSH term is a controlled vocabulary thesaurus developed by the National Library of Medicine for indexing and annotating articles. Our method can effectively identify DDI-relevant MeSH terms such as drugs, proteins and phenomena with high accuracy. The connections among these MeSH terms were investigated by using co-occurrence heatmaps and social network analysis. Our approach can be used to visualize relationships of DDI terms, which has the potential to help users better understand DDIs. As the volume of PubMed records increases, our method for automatic analysis of DDIs from the PubMed database will become more accurate.

Yrkesforberedelse eller fagopplæring med fagbrev? Med design og håndverk som kontekst

Directory of Open Access Journals (Sweden)

Bjørn Magne Aakre

2013-09-01

Full Text Available Artikkelen drøfter forholdet mellom yrkesforberedelse og fagopplæring med utgangspunkt i den kombinerte studieretningen formgivingsfag som ble innført i Norge i 1994. I 2006 ble den delt i et programfag under studiespesialiserende fag, og et nytt yrkesfaglig program med betegnelse design og håndverk. Hvilke interesser lå til grunn for endringene, hvor dyptgripende ble de og hvilke overveieleser kan en gjøre i ettertid om forholdet mellom yrkesforberedelse og fagopplæring? Artikkelen søker å svare på spørsmålene ut fra relevante dokumenter og to kvantitative undersøkelser med elever og lærere som informanter. Artikkelen konkluderer med at innholdet forble nokså likt, antall elever ble halvert og at frafallet økte. Det konkluderes videre med at mange forhold bidrar til å legitimere et fag og dets innhold som henholdsvis skolefag, vitenskapsfag eller yrkesfag. Legitimeringen preges ofte av motstridende motiver og interesser, og sjelden bare faglige begrunnelser.

Redox regulation of the MED28 and MED32 mediator subunits is important for development and senescence.

Science.gov (United States)

Shaikhali, Jehad; Davoine, Céline; Björklund, Stefan; Wingsle, Gunnar

2016-05-01

Mediator is a conserved multi-protein complex that acts as a bridge between promoter-bound transcriptional regulators and RNA polymerase II. While redox signaling is important in adjusting plant metabolism and development, the involvement of Mediator in redox homeostasis and regulation only recently started to emerge. Our previous results show that the MED10a, MED28, and MED32 Mediator subunits form various types of covalent oligomers linked by intermolecular disulfide bonds in vitro. To link that with biological significance we have characterized Arabidopsis med32 and med28 mutants and found that they are affected in root development and senescence, phenotypes possibly associated to redox changes.

DailyMed

Data.gov (United States)

U.S. Department of Health & Human Services — DailyMed provides high quality information about marketed drugs. This information includes FDA labels (package inserts). This Web site provides health information...

Diet and lung cancer

DEFF Research Database (Denmark)

Fabricius, P; Lange, Peter

2003-01-01

Lung cancer is the leading cause of cancer-related deaths worldwide. While cigarette smoking is of key importance, factors such as diet also play a role in the development of lung cancer. MedLine and Embase were searched with diet and lung cancer as the key words. Recently published reviews and l...... are only ameliorated to a minor degree by a healthy diet.......Lung cancer is the leading cause of cancer-related deaths worldwide. While cigarette smoking is of key importance, factors such as diet also play a role in the development of lung cancer. MedLine and Embase were searched with diet and lung cancer as the key words. Recently published reviews...... and large well designed original articles were preferred to form the basis for the present article. A diet rich in fruit and vegetables reduces the incidence of lung cancer by approximately 25%. The reduction is of the same magnitude in current smokers, ex-smokers and never smokers. Supplementation...

MANUAL FOR PROCESORIENTERET MUSIKTERAPI MED PERSONER MED BPD.

Directory of Open Access Journals (Sweden)

Niels Hannibal

2010-12-01

Full Text Available Denne artikel introducerer et musikterapeutisk behandlingskoncept kaldet: Procesorienteret Musikterapi (PROM. PROM er et forsøg på at formulere en principiel ramme for musikterapi i psykiatrien, som dels tager udgangspunkt i 17 års klinisk erfaring, dels stiler mod at være ”best practice”. PROM indeholder beskrivelser af manualens unikke, essentielle men ikke unikke, acceptable og ikke acceptable dele. Den unikke del af PROM skal kunne implementeres til alle målgrupper, mens de øvrige dele af manualen rettes til i forhold til en specifik målgruppe. Denne udgave af PROM er specifikt rettet i mod musikterapi for patienter med personlighedsforstyrrelser. Manualen indgår også som en del af et pilotprojekt, der har til formål at udvikle en protokol for et internationalt RCT projekt med samme målgruppe

Sociale indsatser til mennesker med ADHD

DEFF Research Database (Denmark)

Bengtsson, Steen; Alim, Winnie; Holmskov, Henriette

Igennem de seneste år har flere og flere fået stillet diagnosen ADHD, som er en adfærdsmæssig forstyrrelse. Mennesker med ADHD har meget forskelligt støttebehov, og rapportens formål er at skabe overblik over de eksisterende sociale indsatser og tilbud til børn, unge og voksne med ADHD. Langt de...... ansvar for sociale end for terapeutiske tilbud i forhold til gruppen med ADHD. Mange voksne med ADHD beskriver, at det kræver mange ressourcer at få den fornødne støtte fra kommunen, mens forældre til børn med ADHD oplever det som nemmere at få adgang til de rette støttetilbud. Men begge grupper møder...... mange udfordringer som fx manglende koordinering og hyppige sagsbehandlerskift. Rapporten er udarbejdet i tilknytning til Servicestyrelsens projekt ’Ny og forstærket indsats til børn, unge og voksne med ADHD’ og er finansieret af Socialministeriet....

PubMed

Data.gov (United States)

U.S. Department of Health & Human Services — PubMed comprises more than 26 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to...

PubMed

CERN Document Server

PubMed is the National Library of Medicine's search service that provides access to over 10 million citations in MEDLINE, PreMEDLINE, and other related databases, with links to participating online journals.

Praktische handleiding PubMed : hét boek om snel en doeltreffend te zoeken in PubMed

NARCIS (Netherlands)

Etten-Jamaludin, van F.; Deurenberg, H.W.J.

2010-01-01

Praktische handleidng PubMed is de eerste Nederlandstalige gids die op overzichtelijke wijze op de uitgebreide mogelijkheden van PubMed ingaat. PubMed (www.pubmed.gov) biedt gratis toegang tot MEDLINE en is de meest gebruikte medische zoekmachine. In deze geheel herziene derde editie van Praktisch

Towards PubMed 2.0.

Science.gov (United States)

Fiorini, Nicolas; Lipman, David J; Lu, Zhiyong

2017-10-30

Staff from the National Center for Biotechnology Information in the US describe recent improvements to the PubMed search engine and outline plans for the future, including a new experimental site called PubMed Labs.

Eliminating Late Recurrence to Eradicate Breast Cancer

Science.gov (United States)

2013-09-01

Ranganathan AC, et al. Computational identification of a p38SAPK-regulated transcription factor network required for tumor cell quiescence. Cancer Res. 2009...environment. Cancer Res. 2010; 70:5706– 5716. [PubMed: 20570886] 30. Ranganathan AC, Ojha S, Kourtidis A, Conklin DS, Aguirre-Ghiso JA. Dual function of...pancreatic endoplasmic reticulum kinase in tumor cell growth arrest and survival. Cancer Res. 2008; 68:3260–3268. [PubMed: 18451152] 31. Ranganathan AC

Hvordan er det å leve med CRPS?

OpenAIRE

Hovind, Thomas

2014-01-01

Hensikten med denne studien er å se på hvordan pasienter med komplekst regionalt smertesyndrom (CRPS) opplever å leve med tilstanden og hvordan disse pasientene har opplevd å bli møtt i helsevesenet. CRPS er en langvarig tilstand med sterke smerter som kan medføre økt smerterespons, redusert funksjon og nedsatt livskvalitet hos pasientene. Studien er en kvalitativ undersøkelse basert på dybdeintervju av fire pasienter med CRPS. Pasientene ble rekruttert fra en smerteavdeling i Nord-Norge og u...

The MedCLIVAR Network

Science.gov (United States)

Lionello, Piero; Medclivar sg, The

2013-04-01

The MedCLIVAR initiative was first proposed at the 2003 European Geosciences Union assembly in Nice, France. In 2005, it was endorsed by the International Climate Variability and Predictability (CLIVAR) office. Subsequently, the MedCLIVAR Research Network Project was formally approved by the European Science Foundation and launched in May 2006 with the support of funding agencies from 12 countries. Since then, MedCLIVAR has served as a scientific network to promote interaction among different scientific disciplines and to develop a multidisciplinary vision of the evolution of the Mediterranean climate through studies that integrate atmospheric, marine, and terrestrial climate components at time scales ranging from paleoreconstructions to future climate scenarios. Presently, the network continues dealing with scientific issues including past climate variability; connections between the Mediterranean and global climate; the Mediterranean Sea circulation and sea level; feedbacks on the global climate system; and regional responses to greenhouse gas, air pollution, and aerosols. Its present activities include the publication of a newsletter, the organization of the next MedCLIVAR conference in 2014 and the publication of a special issue of Regional Environmental Change devoted to the climate of the Mediterranean region.

Oncogenic exon 2 mutations in Mediator subunit MED12 disrupt allosteric activation of cyclin C-CDK8/19.

Science.gov (United States)

Park, Min Ju; Shen, Hailian; Spaeth, Jason M; Tolvanen, Jaana H; Failor, Courtney; Knudtson, Jennifer F; McLaughlin, Jessica; Halder, Sunil K; Yang, Qiwei; Bulun, Serdar E; Al-Hendy, Ayman; Schenken, Robert S; Aaltonen, Lauri A; Boyer, Thomas G

2018-03-30

Somatic mutations in exon 2 of the RNA polymerase II transcriptional Mediator subunit MED12 occur at high frequency in uterine fibroids (UFs) and breast fibroepithelial tumors as well as recurrently, albeit less frequently, in malignant uterine leimyosarcomas, chronic lymphocytic leukemias, and colorectal cancers. Previously, we reported that UF-linked mutations in MED12 disrupt its ability to activate cyclin C (CycC)-dependent kinase 8 (CDK8) in Mediator, implicating impaired Mediator-associated CDK8 activity in the molecular pathogenesis of these clinically significant lesions. Notably, the CDK8 paralog CDK19 is also expressed in myometrium, and both CDK8 and CDK19 assemble into Mediator in a mutually exclusive manner, suggesting that CDK19 activity may also be germane to the pathogenesis of MED12 mutation-induced UFs. However, whether and how UF-linked mutations in MED12 affect CDK19 activation is unknown. Herein, we show that MED12 allosterically activates CDK19 and that UF-linked exon 2 mutations in MED12 disrupt its CDK19 stimulatory activity. Furthermore, we find that within the Mediator kinase module, MED13 directly binds to the MED12 C terminus, thereby suppressing an apparent UF mutation-induced conformational change in MED12 that otherwise disrupts its association with CycC-CDK8/19. Thus, in the presence of MED13, mutant MED12 can bind, but cannot activate, CycC-CDK8/19. These findings indicate that MED12 binding is necessary but not sufficient for CycC-CDK8/19 activation and reveal an additional step in the MED12-dependent activation process, one critically dependent on MED12 residues altered by UF-linked exon 2 mutations. These findings confirm that UF-linked mutations in MED12 disrupt composite Mediator-associated kinase activity and identify CDK8/19 as prospective therapeutic targets in UFs. © 2018 Park et al.

Redefining the MED13L syndrome.

Science.gov (United States)

Adegbola, Abidemi; Musante, Luciana; Callewaert, Bert; Maciel, Patricia; Hu, Hao; Isidor, Bertrand; Picker-Minh, Sylvie; Le Caignec, Cedric; Delle Chiaie, Barbara; Vanakker, Olivier; Menten, Björn; Dheedene, Annelies; Bockaert, Nele; Roelens, Filip; Decaestecker, Karin; Silva, João; Soares, Gabriela; Lopes, Fátima; Najmabadi, Hossein; Kahrizi, Kimia; Cox, Gerald F; Angus, Steven P; Staropoli, John F; Fischer, Ute; Suckow, Vanessa; Bartsch, Oliver; Chess, Andrew; Ropers, Hans-Hilger; Wienker, Thomas F; Hübner, Christoph; Kaindl, Angela M; Kalscheuer, Vera M

2015-10-01

Congenital cardiac and neurodevelopmental deficits have been recently linked to the mediator complex subunit 13-like protein MED13L, a subunit of the CDK8-associated mediator complex that functions in transcriptional regulation through DNA-binding transcription factors and RNA polymerase II. Heterozygous MED13L variants cause transposition of the great arteries and intellectual disability (ID). Here, we report eight patients with predominantly novel MED13L variants who lack such complex congenital heart malformations. Rather, they depict a syndromic form of ID characterized by facial dysmorphism, ID, speech impairment, motor developmental delay with muscular hypotonia and behavioral difficulties. We thereby define a novel syndrome and significantly broaden the clinical spectrum associated with MED13L variants. A prominent feature of the MED13L neurocognitive presentation is profound language impairment, often in combination with articulatory deficits.

Redefining the MED13L syndrome

Science.gov (United States)

Adegbola, Abidemi; Musante, Luciana; Callewaert, Bert; Maciel, Patricia; Hu, Hao; Isidor, Bertrand; Picker-Minh, Sylvie; Le Caignec, Cedric; Delle Chiaie, Barbara; Vanakker, Olivier; Menten, Björn; Dheedene, Annelies; Bockaert, Nele; Roelens, Filip; Decaestecker, Karin; Silva, João; Soares, Gabriela; Lopes, Fátima; Najmabadi, Hossein; Kahrizi, Kimia; Cox, Gerald F; Angus, Steven P; Staropoli, John F; Fischer, Ute; Suckow, Vanessa; Bartsch, Oliver; Chess, Andrew; Ropers, Hans-Hilger; Wienker, Thomas F; Hübner, Christoph; Kaindl, Angela M; Kalscheuer, Vera M

2015-01-01

Congenital cardiac and neurodevelopmental deficits have been recently linked to the mediator complex subunit 13-like protein MED13L, a subunit of the CDK8-associated mediator complex that functions in transcriptional regulation through DNA-binding transcription factors and RNA polymerase II. Heterozygous MED13L variants cause transposition of the great arteries and intellectual disability (ID). Here, we report eight patients with predominantly novel MED13L variants who lack such complex congenital heart malformations. Rather, they depict a syndromic form of ID characterized by facial dysmorphism, ID, speech impairment, motor developmental delay with muscular hypotonia and behavioral difficulties. We thereby define a novel syndrome and significantly broaden the clinical spectrum associated with MED13L variants. A prominent feature of the MED13L neurocognitive presentation is profound language impairment, often in combination with articulatory deficits. PMID:25758992

Tang med omtanke

DEFF Research Database (Denmark)

Schlundt, Jørgen

2013-01-01

Befolkningen bør kende både mulige positive og negative effekter af fødevarer, før de spiser dem. Det mener Jørgen Schlundt, DTU Fødevareinstituttet, med henvisning til Ole G. Mouritsens kritik af instituttets udmeldinger om tang i det seneste nummer af Aktuel Naturvidenskab.......Befolkningen bør kende både mulige positive og negative effekter af fødevarer, før de spiser dem. Det mener Jørgen Schlundt, DTU Fødevareinstituttet, med henvisning til Ole G. Mouritsens kritik af instituttets udmeldinger om tang i det seneste nummer af Aktuel Naturvidenskab....

TwiMed: Twitter and PubMed Comparable Corpus of Drugs, Diseases, Symptoms, and Their Relations.

Science.gov (United States)

Alvaro, Nestor; Miyao, Yusuke; Collier, Nigel

2017-05-03

Work on pharmacovigilance systems using texts from PubMed and Twitter typically target at different elements and use different annotation guidelines resulting in a scenario where there is no comparable set of documents from both Twitter and PubMed annotated in the same manner. This study aimed to provide a comparable corpus of texts from PubMed and Twitter that can be used to study drug reports from these two sources of information, allowing researchers in the area of pharmacovigilance using natural language processing (NLP) to perform experiments to better understand the similarities and differences between drug reports in Twitter and PubMed. We produced a corpus comprising 1000 tweets and 1000 PubMed sentences selected using the same strategy and annotated at entity level by the same experts (pharmacists) using the same set of guidelines. The resulting corpus, annotated by two pharmacists, comprises semantically correct annotations for a set of drugs, diseases, and symptoms. This corpus contains the annotations for 3144 entities, 2749 relations, and 5003 attributes. We present a corpus that is unique in its characteristics as this is the first corpus for pharmacovigilance curated from Twitter messages and PubMed sentences using the same data selection and annotation strategies. We believe this corpus will be of particular interest for researchers willing to compare results from pharmacovigilance systems (eg, classifiers and named entity recognition systems) when using data from Twitter and from PubMed. We hope that given the comprehensive set of drug names and the annotated entities and relations, this corpus becomes a standard resource to compare results from different pharmacovigilance studies in the area of NLP. ©Nestor Alvaro, Yusuke Miyao, Nigel Collier. Originally published in JMIR Public Health and Surveillance (http://publichealth.jmir.org), 03.05.2017.

Characterization of the mechanism of drug-drug interactions from PubMed using MeSH terms.

Directory of Open Access Journals (Sweden)

Yin Lu

Full Text Available Identifying drug-drug interaction (DDI is an important topic for the development of safe pharmaceutical drugs and for the optimization of multidrug regimens for complex diseases such as cancer and HIV. There have been about 150,000 publications on DDIs in PubMed, which is a great resource for DDI studies. In this paper, we introduced an automatic computational method for the systematic analysis of the mechanism of DDIs using MeSH (Medical Subject Headings terms from PubMed literature. MeSH term is a controlled vocabulary thesaurus developed by the National Library of Medicine for indexing and annotating articles. Our method can effectively identify DDI-relevant MeSH terms such as drugs, proteins and phenomena with high accuracy. The connections among these MeSH terms were investigated by using co-occurrence heatmaps and social network analysis. Our approach can be used to visualize relationships of DDI terms, which has the potential to help users better understand DDIs. As the volume of PubMed records increases, our method for automatic analysis of DDIs from the PubMed database will become more accurate.

Photodynamic Therapy for Cancer

Science.gov (United States)

... et al. Photodynamic therapy. Journal of the National Cancer Institute 1998; 90(12):889–905. [PubMed Abstract] Gudgin Dickson EF, Goyan RL, Pottier RH. New directions in photodynamic therapy. Cellular and Molecular Biology 2002; 48(8):939–954. [PubMed Abstract] Capella ...

PubMed Informer: Monitoring MEDLINE/PubMed through E-mail Alerts, SMS, PDA downloads and RSS feeds

Science.gov (United States)

Muin, Michael; Fontelo, Paul; Ackerman, Michael

2005-01-01

Summary PubMed Informer is a Web-based monitoring tool for topics of interest from MEDLINE/PubMed primarily designed for healthcare professionals. Five tracking methods are available: Web access, e-mail, Short Message Service (SMS), PDA downloads and RSS feeds. PubMed Informer delivers focused search updates and specific information to users with varying information-seeking practices. PMID:16779344

Helicobacter pylori and Cancer

Science.gov (United States)

... pattern of the disease and an overview of environmental risk factors. Best Practice & Research Clinical Gastroenterology 2006; 20(4):633–649. [PubMed Abstract] Brenner H, Rothenbacher D, Arndt V. Epidemiology of stomach cancer. Methods in Molecular Biology 2009; 472:467–477. [PubMed ...

A marvel of precision: MedAustron

CERN Document Server

Anaïs Schaeffer

2013-01-01

MedAustron, which is currently being built in Austria, will be one of the most advanced centres for ion beam therapy and research in Europe. It is based on the same design as the Italian National Centre for Oncological Hadrontherapy (CNAO), which in turn is based on the CERN-led Proton Ion Medical Machine Study (PIMMS). MedAustron should welcome its first patient at the end of 2015.   Layout of the MedAustron accelerator complex.  With three ion-sources, a linac, a synchrotron and four irradiation rooms (see picture), MedAustron is a huge accelerator complex. Among other equipment, it comprises 300 magnets of 30 different types, all designed at CERN but produced at different sites: “We are working with five main suppliers from Europe and Russia,” explains Thomas Zickler, leader of the MedAustron magnet group. “All the magnets come to CERN to undergo a series of strict acceptance tests.” From the interfaces, to the electrical insulation, the co...

The Arabidopsis mediator complex subunits MED16, MED14, and MED2 regulate mediator and RNA polymerase II recruitment to CBF-responsive cold-regulated genes.

Science.gov (United States)

Hemsley, Piers A; Hurst, Charlotte H; Kaliyadasa, Ewon; Lamb, Rebecca; Knight, Marc R; De Cothi, Elizabeth A; Steele, John F; Knight, Heather

2014-01-01

The Mediator16 (MED16; formerly termed SENSITIVE TO FREEZING6 [SFR6]) subunit of the plant Mediator transcriptional coactivator complex regulates cold-responsive gene expression in Arabidopsis thaliana, acting downstream of the C-repeat binding factor (CBF) transcription factors to recruit the core Mediator complex to cold-regulated genes. Here, we use loss-of-function mutants to show that RNA polymerase II recruitment to CBF-responsive cold-regulated genes requires MED16, MED2, and MED14 subunits. Transcription of genes known to be regulated via CBFs binding to the C-repeat motif/drought-responsive element promoter motif requires all three Mediator subunits, as does cold acclimation-induced freezing tolerance. In addition, these three subunits are required for low temperature-induced expression of some other, but not all, cold-responsive genes, including genes that are not known targets of CBFs. Genes inducible by darkness also required MED16 but required a different combination of Mediator subunits for their expression than the genes induced by cold. Together, our data illustrate that plants control transcription of specific genes through the action of subsets of Mediator subunits; the specific combination defined by the nature of the stimulus but also by the identity of the gene induced.

Mødet med det Andet

DEFF Research Database (Denmark)

Marchwinski, Alena

2002-01-01

Da Christen Købke i 1830 malte sitt bilde fra Kunstakademiets avstøpningssamling på Charlottenborg, skildret han en situasjon som vordende danske kunstnere hadde vært fortrolige med i flere generasjoner: en ung mann betrakter en avstøpning av en antikk skulptur. Med utgangspunkt i kombinasjonen a...

Et felteksperiment med Kærlighed i Kaos

DEFF Research Database (Denmark)

Christensen, Christiane Præstgaard; Scavenius Sonne-Schmidt, Christoffer

Som et nyt tilbud til danske forældre med børn med ADHD og ADHD-lignende vanskeligheder har ADHDforeningen udviklet forældretræningsprogrammet Kærlighed i Kaos, hvor frivillige hjælper forældre til børn med ADHD, der står med et særligt vanskeligt opdragelsesarbejde. Denne rapport har til formål......, når forældrene stiller krav til børnene. Resultaterne i denne rapport har interesse for fagpersoner, behandlere, undervisere, beslutningstagere, frivillige organisationer, foreninger og de mange nuværende og kommende familier, som dagligt kæmper med adfærdsvanskeligheder – såsom ADHD. Effektmålingen...

Redefining the MED13L syndrome

OpenAIRE

Adegbola, Abidemi; Musante, Luciana; Callewaert, Bert; Maciel, Patricia; Hu, Hao; Isidor, Bertrand; Picker-Minh, Sylvie; Le Caignec, Cedric; Delle Chiaie, Barbara; Vanakker, Olivier; Menten, Björn; Dheedene, Annelies; Bockaert, Nele; Roelens, Filip; Decaestecker, Karin

2015-01-01

Congenital cardiac and neurodevelopmental deficits have been recently linked to the mediator complex subunit 13-like protein MED13L, a subunit of the CDK8-associated mediator complex that functions in transcriptional regulation through DNA-binding transcription factors and RNA polymerase II. Heterozygous MED13L variants cause transposition of the great arteries and intellectual disability (ID). Here, we report eight patients with predominantly novel MED13L variants who lack such complex conge...

Genetics Home Reference: prostate cancer

Science.gov (United States)

... Jan;73(2):169-75. doi: 10.1002/pros.22552. Epub 2012 Jun 21. Citation on PubMed or Free article on PubMed Central Nakagawa H. Prostate cancer genomics by high-throughput technologies: genome-wide association study and sequencing analysis. Endocr ...

Bleomycin--electrical pulse delivery: electroporation therapy-bleomycin--Genetronics; MedPulser-bleomycin--Genetronics.

Science.gov (United States)

2004-01-01

Genetronics Biomedical is using its electroporation therapy technology to deliver bleomycin to tumour cells for the treatment of cancer. Genetronics have developed the MedPulser Electroporation Therapy System, which consists of an electrical pulse generator and disposable electrode applicators. The MedPulser system enables the delivery of large molecules into cells by briefly applying an electric field to the cell. This causes a transient permeability in the cell's outer membrane characterised by the appearance of pores across the membrane. After the field is discontinued, the pores close, trapping the therapeutic molecules inside the target cells. Genetronics is using the MedPulser System in conjunction with bleomycin, an antineoplastic antibiotic that binds to DNA causing strand scissions. Genetronics is seeking a licensing partner for the use of electroporation for the delivery of drugs in chemotherapy. In 1998, Genetronics entered a licensing and development agreement with Ethicon for electroporation and electrofusion. Under the terms of this agreement, Ethicon was to develop and clinically test the Genetronics electroporation delivery system and conduct all regulatory activities throughout the world except Canada. Ethicon would also market the products once regulatory approval has been obtained and Genetronics was to receive a percentage of the net sales and as license fees. However, in July 2000, Ethicon exercised its rights to terminate the agreement without cause. All rights were returned to Genetronics in January 2001. In 1997, Genetronics entered an agreement with Abbott Laboratories for the manufacture of bleomycin for use in the US in its MedPulsar system after regulatory approval had been granted for its use in the treatment of solid tumours. In a separate supply agreement, Faulding Inc. has agreed to manufacture bleomycin for Genetronic for use in Canada after regulatory approval had been granted. The MedPulsar Electroporation Therapy System with

Med det sociale som designmateriale

DEFF Research Database (Denmark)

Brandt, Eva; Binder, Thomas

2016-01-01

Samarbejde, samskabelse og social nysgerrighed er i dag en præmis for den nyskabende designer. Det sociale er det nye designmateriale som unge designere giver sig i kast med når f.eks. Emmy Linde samarbejder med plejehjemsbeboere, deres pårørende, plejepersonale og fysioterapeuter for at designe ...

Adherence to the Mediterranean diet and risk of lung cancer in the Netherlands Cohort Study.

Science.gov (United States)

Schulpen, Maya; van den Brandt, Piet A

2018-03-01

The evidence on a cancer-protective effect of the Mediterranean diet (MD) is still limited. Therefore, we investigated the association between MD adherence and lung cancer risk. Data were used from 120 852 participants of the Netherlands Cohort Study (NLCS), aged 55-69 years. Dietary habits were assessed at baseline (1986) using a validated FFQ and alternate and modified Mediterranean diet scores (aMED and mMED, respectively), including and excluding alcohol, were calculated. After 20·3 years of follow-up, 2861 lung cancer cases and 3720 subcohort members (case-cohort design) could be included in multivariable Cox regression analyses. High (6-8) v. low (0-3) aMED excluding alcohol was associated with non-significantly reduced lung cancer risks in men and women with hazard ratios of 0·91 (95 % CI 0·72, 1·15) and 0·73 (95 % CI 0·49, 1·09), respectively. aMED-containing models generally fitted better than mMED-containing models. In never smokers, a borderline significant decreasing trend in lung cancer risk was observed with increasing aMED excluding alcohol. Analyses stratified by the histological lung cancer subtypes did not identify subtypes with a particularly strong inverse relation with MD adherence. Generally, the performance of aMED and World Cancer Research Fund/American Institute for Cancer Research dietary score variants without alcohol was comparable. In conclusion, MD adherence was non-significantly inversely associated with lung cancer risk in the NLCS. Future studies should focus on differences in associations across the sexes and histological subtypes. Furthermore, exclusion of alcohol from MD scores should be investigated more extensively, primarily with respect to a potential role of the MD in cancer prevention.

Human melioidosis reported by ProMED

Directory of Open Access Journals (Sweden)

Katherinn Melissa Nasner-Posso

2015-06-01

Conclusions: Internet-based reporting systems such as ProMED are useful to gather information and synthesize knowledge on emerging infections. Although certain areas need to be improved, ProMED provided good information about melioidosis.

Musikalsk leg med formgivning, timing og vitalitetsformer

DEFF Research Database (Denmark)

Holck, Ulla

2015-01-01

Ifølge de Udviklingsorienterede Social-Pragmatiske Interventionsformer til børn med Autisme Spektrum Forstyrrelse er en legende indfaldsvinkel, hvor man følger barnets lead, den mest effektive til at engagere yngre børn med autisme eller børn med svær autisme i et gensidigt samspil. Artiklen...

Med-E-Tel

National Research Council Canada - National Science Library

Lievens, Frank; Jordanova, Malina

2006-01-01

.... The Med-e-Tel 2006 conference program covered over 130 presentations on topics such as homecare and health management, healthcare challenges, tele-education, eHealth in developing countries, telecardiology...

Med-E-Tel

National Research Council Canada - National Science Library

Lievens, Frank; Jordanova, Malina

2006-01-01

..., and more. The Med-e-Tel 2006 exhibition showcased products and technologies in the areas of medication compliance, home telehealth and vital sign monitoring, clinical software, electronic medical records...

At lede med latter

DEFF Research Database (Denmark)

Møller, Mette

2014-01-01

"Det sagde hun også i går!" Platte vitser, der lægger op til den karakteristiske 'bodom-tchi'-trommelyd, behøver ikke være lederens eneste forsøg på at udvise humoristisk sans på talerstolen. For humor kan være meget andet og gøre meget mere for lederen end at score billige point med en spontan s...... spøg. Humor kan skabe klarhed over en pointe, skabe lederens image og skabe sammenhold i organisationen. Uden trommelyd, men med mange andre effekter i spil....

Predicting clicks of PubMed articles.

Science.gov (United States)

Mao, Yuqing; Lu, Zhiyong

2013-01-01

Predicting the popularity or access usage of an article has the potential to improve the quality of PubMed searches. We can model the click trend of each article as its access changes over time by mining the PubMed query logs, which contain the previous access history for all articles. In this article, we examine the access patterns produced by PubMed users in two years (July 2009 to July 2011). We explore the time series of accesses for each article in the query logs, model the trends with regression approaches, and subsequently use the models for prediction. We show that the click trends of PubMed articles are best fitted with a log-normal regression model. This model allows the number of accesses an article receives and the time since it first becomes available in PubMed to be related via quadratic and logistic functions, with the model parameters to be estimated via maximum likelihood. Our experiments predicting the number of accesses for an article based on its past usage demonstrate that the mean absolute error and mean absolute percentage error of our model are 4.0% and 8.1% lower than the power-law regression model, respectively. The log-normal distribution is also shown to perform significantly better than a previous prediction method based on a human memory theory in cognitive science. This work warrants further investigation on the utility of such a log-normal regression approach towards improving information access in PubMed.

Breast cancer and depression: issues in clinical care

Directory of Open Access Journals (Sweden)

Thingbaijam B. Singh

2012-11-01

Full Text Available Many of breast-cancer patients experience distress and most of them experience depression which may lead to amplification of physical symptoms, increased functional impairment, and poor treatment adherence. We did a review on available literature from PubMed about prevalence, distress magnitudes, coping styles, and treatment methods of major depression in women with breast cancer from 1978 to 2010. Diagnosis and treatment of depressive episodes in women with breast cancer is challenging because of overlapping symptoms and co-morbid conditions. Major depression is often under-recognized and undertreated among breast cancer patients. This review highlighted the issues on identifying and managing depression in breast cancer patients in clinical settings. (Med J Indones. 2012;21:240-6Keywords: Breast cancer, coping, depression, distress

Akupunktur til patienten med kvalme og opkastning i forbindelse med kemoterapi - er der evidens for dette?

DEFF Research Database (Denmark)

Pedersen, Birgith; Sørensen, Lene Bundgaard; Stricker, Lisbeth

2008-01-01

  Patienter, der får kemoterapi med højemetogene stoffer lider stadig af kvalme og opkastning trods understøttende behandling med moderne antieemtika som 5HT3-antagonister eksempelvis ondansetron. Akupunkturstimulation anvendes for flere lidelser i sundhedsvæsenet og det undersøges om der er evid...

Technical development of PubMed Interact: an improved interface for MEDLINE/PubMed searches

OpenAIRE

Muin, Michael; Fontelo, Paul

2006-01-01

Abstract Background The project aims to create an alternative search interface for MEDLINE/PubMed that may provide assistance to the novice user and added convenience to the advanced user. An earlier version of the project was the 'Slider Interface for MEDLINE/PubMed searches' (SLIM) which provided JavaScript slider bars to control search parameters. In this new version, recent developments in Web-based technologies were implemented. These changes may prove to be even more valuable in enhanci...

Grateful Med: getting started.

Science.gov (United States)

Shearer, B; McCann, L; Crump, W J

1990-01-01

When a local medical library is not available, it is often necessary for physicians to discover alternate ways to receive medical information. Rural physicians, particularly, can make use of a computer program called Grateful Med that provides access to the same literature available to physicians in large cities. This program permits the user to perform database searches on the National Library of Medicine database (MEDLINE), corresponding to the primary index to medical literature, Index Medicus. In this article, we give the procedure for procuring a National Library of Medicine password and for making efficient use of the Grateful Med program.

Human melioidosis reported by ProMED.

Science.gov (United States)

Nasner-Posso, Katherinn Melissa; Cruz-Calderón, Stefania; Montúfar-Andrade, Franco E; Dance, David A B; Rodriguez-Morales, Alfonso J

2015-06-01

There are limited sources describing the global burden of emerging diseases. A review of human melioidosis reported by ProMED was performed and the reliability of the data retrieved assessed in comparison to published reports. The effectiveness of ProMED was evaluated as a source of epidemiological data by focusing on melioidosis. Using the keyword 'melioidosis' in the ProMED search engine, all of the information from the reports and collected data was reviewed using a structured form, including the year, country, gender, occupation, number of infected individuals, and number of fatal cases. One hundred and twenty-four entries reported between January 1995 and October 2014 were identified. A total of 4630 cases were reported, with death reported in 505 cases, suggesting a misleadingly low overall case fatality rate (CFR) of 11%. Of 20 cases for which the gender was reported, 12 (60%) were male. Most of the cases were reported from Australia, Thailand, Singapore, Vietnam, and Malaysia, with sporadic reports from other countries. Internet-based reporting systems such as ProMED are useful to gather information and synthesize knowledge on emerging infections. Although certain areas need to be improved, ProMED provided good information about melioidosis. Copyright © 2015 The Authors. Published by Elsevier Ltd.. All rights reserved.

MED-SUV Data Life Cycle

Science.gov (United States)

Sangianantoni, Agata; Puglisi, Giuseppe; Spampinato, Letizia; Tulino, Sabrina

2015-04-01

The MED-SUV project aims to implement a digital e-infrastructure for data access in order to promote the monitoring and study of key volcanic regions prone to volcanic hazards, and thus improve hazard assessment, according to the rationale of Supersite GEO initiative to Vesuvius- Campi Flegrei and Mt Etna, currently identified as Permanent Supersites. The present study focuses on the life cycle of MED-SUV data generated in the first period of the project and highlights the managing approach, as well as the crucial steps to be implemented for ensuring that data will be properly and ethically managed and can be used and accessed from both MED-SUV and the external community. The process is conceived outlining how research data being handled as the project progresses, describing what data are collected, processed or generated and how these data are going to be shared and made available through Open Access. Data cycle begins with their generation and ends with the deposit in the digital infrastructure, its key series of stages through which MED-SUV data passes are Collection, Data citation, Categorization of data, Approval procedure, Registration of datasets, Application of licensing models, and PID assignment. This involves a combination of procedures and practices taking into account the scientific core mission and the priorities of the project as well as the potential legal issues related to the management and protection of the Intellectual Property. We believe that the implementation of this process constitutes a significant encouragement in MED-SUV data sharing and as a consequence a better understanding on the volcanic processes, hazard assessment and a better integration with other Supersites projects.

The Arabidopsis Mediator Complex Subunits MED16, MED14, and MED2 Regulate Mediator and RNA Polymerase II Recruitment to CBF-Responsive Cold-Regulated Genes[C][W][OPEN

Science.gov (United States)

Hemsley, Piers A.; Hurst, Charlotte H.; Kaliyadasa, Ewon; Lamb, Rebecca; Knight, Marc R.; De Cothi, Elizabeth A.; Steele, John F.; Knight, Heather

2014-01-01

The Mediator16 (MED16; formerly termed SENSITIVE TO FREEZING6 [SFR6]) subunit of the plant Mediator transcriptional coactivator complex regulates cold-responsive gene expression in Arabidopsis thaliana, acting downstream of the C-repeat binding factor (CBF) transcription factors to recruit the core Mediator complex to cold-regulated genes. Here, we use loss-of-function mutants to show that RNA polymerase II recruitment to CBF-responsive cold-regulated genes requires MED16, MED2, and MED14 subunits. Transcription of genes known to be regulated via CBFs binding to the C-repeat motif/drought-responsive element promoter motif requires all three Mediator subunits, as does cold acclimation–induced freezing tolerance. In addition, these three subunits are required for low temperature–induced expression of some other, but not all, cold-responsive genes, including genes that are not known targets of CBFs. Genes inducible by darkness also required MED16 but required a different combination of Mediator subunits for their expression than the genes induced by cold. Together, our data illustrate that plants control transcription of specific genes through the action of subsets of Mediator subunits; the specific combination defined by the nature of the stimulus but also by the identity of the gene induced. PMID:24415770

Tandlæger og personer med en spiseforstyrrelse

DEFF Research Database (Denmark)

Gehrt, Charlotte Astrid; Christensen, Lisa Bøge; Klinker, Sabine

2016-01-01

Mødet mellem tandlæge og patient med spiseforstyrrelse Introduktion og formål: Det er velkendt, at tandlæger kan spille en rolle i forhold til tidlig identifikation af en spiseforstyrrelse. Der erimidlertid begrænset viden om, hvilke forventninger tandlæger og personer med en spiseforstyrrelse har...... til mødet med hinanden i klinikken, og hvordan dette opleves. Undersøgelsens formål var derfor at få viden om mødet mellem tandlæger og personer med en spiseforstyrrelse. Materialer og metoder: Undersøgelsen var en tværsnitsundersøgelse baseret på to spørgeskemaer udarbejdet til henholdsvis tandlæger...... og personer med en spiseforstyrrelse. I alt 1.405 tandlæger deltog, mens 260 personer med en spiseforstyrrelse besvarede spørgeskemaet. Resultater: Tandlægerne havde større selvrapporteret viden om orale komplikationer ved en spiseforstyrrelse end om spiseforstyrrelser generelt. Størstedelen af...

MedAustron - Ion-Beam Therapy and Research Center

International Nuclear Information System (INIS)

Schreiner, Thomas; Seemann, Rolf

2015-01-01

MedAustron is a synchrotron-based light-ion beam therapy center for cancer treatment as well as for clinical and non-clinical research, currently in the commissioning phase in Wiener Neustadt, Austria. Recently, the first proton beam was transported successfully to one of the four irradiation rooms. Whilst the choice of basic machine parameters was driven by medical requirements, i.e. 60 MeV protons and 120 MeV/A to 400 MeV/A carbon ions, the accelerator complex design was also optimized to offer flexibility for research operation. The potential of the synchrotron is being exploited to increase the maximum proton energy far beyond the medical needs to up to 800 MeV, for experimental physics applications, mainly in the areas of proton scattering and detector research. The accelerator layout allows for the installation of up to four ion source-spectrometer units, to provide various ion types besides the clinical used protons and carbon ions. Besides experimental physics, the two main non-clinical research disciplines are medical radiation physics and radiation biology. To decouple research and medical operation, a dedicated irradiation room for non-clinical research was included providing the installation of different experiments. In addition, several labs have been equipped with appropriate devices for preparing and analyzing radio-biological samples. This presentation gives a status overview over the whole project and highlights the non-clinical research opportunities at MedAustron. (Author)

Cancer awareness and socio-economic position

DEFF Research Database (Denmark)

Hvidberg, Line; Pedersen, Anette Fischer; Wulff, Christian Nielsen

2014-01-01

Formålet med dette studie var at undersøge ”cancer awareness”, dvs. kendskabet til symptomer på kræft, risikofaktorer for kræft og 5-års overlevelsen for fire kræfttyper, i en dansk population. Derudover ses der nærmere på sammenhænge mellem socio-økonomisk position og ”cancer awareness......”. Resultaterne viser, at der er en stærk social gradient i ”cancer awareness”. Personer med et lavt uddannelsesniveau og en lav husstandsindkomst var mindre tilbøjelige til at genkende symptomer på kræft og risikofaktorer for kræft end personer med et højt uddannelsesniveau og en høj husstandsindkomst....... Resultaterne viser dog ingen klar sammenhæng mellem socio-økonomisk position og kendskabet til 5-års overlevelsen af kræft. Studiet bygger på data fra i alt 3.000 tilfældigt udvalgte danskere (på mindst 30 år), som besvarede den danske version af spørgeskemaet ”Awareness and Beliefs about Cancer”. Da ”cancer...

Hvad skal vi med Etisk Råd?

DEFF Research Database (Denmark)

Ploug, Thomas; Gjerris, Mickey

2012-01-01

Det Etiske Råd har for os at se en væsentlig rolle at spille i et åbent og demokratisk samfund som det danske. Vi skal være med til at skabe grobund for de værdidiskussioner, som skal forme fremtidens samfund. Etik er at være i dialog – ikke at kaste med mudder.......Det Etiske Råd har for os at se en væsentlig rolle at spille i et åbent og demokratisk samfund som det danske. Vi skal være med til at skabe grobund for de værdidiskussioner, som skal forme fremtidens samfund. Etik er at være i dialog – ikke at kaste med mudder....

OvidSP Medline-to-PubMed search filter translation: a methodology for extending search filter range to include PubMed's unique content.

Science.gov (United States)

Damarell, Raechel A; Tieman, Jennifer J; Sladek, Ruth M

2013-07-02

PubMed translations of OvidSP Medline search filters offer searchers improved ease of access. They may also facilitate access to PubMed's unique content, including citations for the most recently published biomedical evidence. Retrieving this content requires a search strategy comprising natural language terms ('textwords'), rather than Medical Subject Headings (MeSH). We describe a reproducible methodology that uses a validated PubMed search filter translation to create a textword-only strategy to extend retrieval to PubMed's unique heart failure literature. We translated an OvidSP Medline heart failure search filter for PubMed and established version equivalence in terms of indexed literature retrieval. The PubMed version was then run within PubMed to identify citations retrieved by the filter's MeSH terms (Heart failure, Left ventricular dysfunction, and Cardiomyopathy). It was then rerun with the same MeSH terms restricted to searching on title and abstract fields (i.e. as 'textwords'). Citations retrieved by the MeSH search but not the textword search were isolated. Frequency analysis of their titles/abstracts identified natural language alternatives for those MeSH terms that performed less effectively as textwords. These terms were tested in combination to determine the best performing search string for reclaiming this 'lost set'. This string, restricted to searching on PubMed's unique content, was then combined with the validated PubMed translation to extend the filter's performance in this database. The PubMed heart failure filter retrieved 6829 citations. Of these, 834 (12%) failed to be retrieved when MeSH terms were converted to textwords. Frequency analysis of the 834 citations identified five high frequency natural language alternatives that could improve retrieval of this set (cardiac failure, cardiac resynchronization, left ventricular systolic dysfunction, left ventricular diastolic dysfunction, and LV dysfunction). Together these terms reclaimed

Ti år med formidlingspligt

DEFF Research Database (Denmark)

Meyer, Gitte

2014-01-01

Jubilæet blev markeret ved et symposium - men hvor var journalisterne, og hvor var forskerne? For få uger siden lagde TV 2 hus til et symposium om videnskab, formidling, journalistik og spin. Danske Videnskabsjournalister og Akademiet for de Tekniske Videnskaber tog med arrangementet et behjertet...... initiativ. De ville gøre status efter ti år med lovfæstet formidlingspligt på universiteterne. Samtidig lagde de op til et kritisk blik på universitetsverdenens kommunikationsafdelinger...

Bygningsdele med celluloseuld og høruld

DEFF Research Database (Denmark)

Hansen, Ernst Jan de Place

2001-01-01

Resume af rapport med eksempler på bygningsdele med papir- eller hørisolering, der overholder bygningsreglementerne, udarbejdet af Dansk Brandteknisk Institut under Energistyrelsens udviklingsprogram "Miljø- og arbejdsmiljøvenlig isolering"...

Social indsats til borgere med erfaring fra salg af sex

DEFF Research Database (Denmark)

Mehlsen, Line; Amilon, Anna; Henriksen, Theresa Dyrvig

2017-01-01

Formålet med denne guide er at give endnu flere kommuner inspiration og vejledning til, hvordan man kan implementere og arbejde med CTI-forløb over for borgere med prostitutionserfaring. Manglende viden om borgere med prostitutionserfaringer gør det svært for kommunerne at hjælpe borgerne med de ...

Specifik mutation med nålestiksoperation

DEFF Research Database (Denmark)

Holme, Inger; Wendt, Toni; Brinch-Pedersen, Henrik

2014-01-01

Mutanter af byg er vigtige i forskningen og benyttes også, når der forædles nye sorter til dyrkning. Hidtil har det kun været muligt at inducere mutationer tilfældige steder i genomet. Med helt ny teknologi benyttes proteiner med betegnelsen TALENs til at inducere mutationer i helt specifikke...

Med sjefen på Facebook: En studie av ledere som er "venner" med sine ansatte

OpenAIRE

Jensen, Anita

2014-01-01

MR690 Masteroppgave i organisasjon og ledelse - utdanningsledelse Formålet med studien er å belyse hvordan aktiv bruk av sosiale medier, i dette tilfellet Facebook, påvirker relasjoner mellom mennesker. Hva skjer når en tar i bruk en websjanger som i utgangspunktet er umiddelbar og uformell, til jobbrelatert og mer formell kommunikasjon? Er det sjangeren eller relasjonen som endres? Søkelyset rettes mot ledere som er “venner” med sine medarbeidere, og problemstillingen er...

Dose distribution and dosimetry parameters calculation of MED3633 Palladium-103 source in water phantom using MCNP

International Nuclear Information System (INIS)

Mowlavi, A. A.; Binesh, A.; Moslehitabar, H.

2006-01-01

Palladium-103 ( 103 Pd) is a brachytherapy source for cancer treatment. The Monte Carlo codes are usually applied for dose distribution and effect of shieldings. Monte Carlo calculation of dose distribution in water phantom due to a MED3633 103 Pd source is presented in this work. Materials and Methods: The dose distribution around the 10 3Pd Model MED3633 located in the center of 30*30*30 m 3 water phantom cube was calculated using MCNP code by the Monte Carlo method. The percentage depth dose variation along the different axis parallel and perpendicular to the source was also calculated. Then, the isodose curves for 100%, 75%, 50% and 25% percentage depth dose and dosimetry parameters of TG-43 protocol were determined. Results: The results show that the Monte Carlo Method could calculate dose deposition in high gradient region, near the source, accurately. The isodose curves and dosimetric characteristics obtained for MED3633 103 Pd source are in good agreement with published results. Conclusion: The isodose curves of the MED3633 103 Pd source have been derived form dose calculation by MCNP code. The calculated dosimetry parameters for the source agree quite well with their Monte Carlo calculated and experimental measurement values

Geograf med GIS som ledetråd

DEFF Research Database (Denmark)

Nielsen, Søren Zebitz

2013-01-01

Fra speciale om kortlægning af luft forurening med NO2 i troposfæren målt fra satellit til PhD studerende med fokus på forståelsen af menneskers bevægelsesmønstre i byer. GIS og geodata er den røde tråd der binder de brede interesser indenfor geografi en sammen for denne forskerlærling.......Fra speciale om kortlægning af luft forurening med NO2 i troposfæren målt fra satellit til PhD studerende med fokus på forståelsen af menneskers bevægelsesmønstre i byer. GIS og geodata er den røde tråd der binder de brede interesser indenfor geografi en sammen for denne forskerlærling....

PubMed searches: overview and strategies for clinicians.

Science.gov (United States)

Lindsey, Wesley T; Olin, Bernie R

2013-04-01

PubMed is a biomedical and life sciences database maintained by a division of the National Library of Medicine known as the National Center for Biotechnology Information (NCBI). It is a large resource with more than 5600 journals indexed and greater than 22 million total citations. Searches conducted in PubMed provide references that are more specific for the intended topic compared with other popular search engines. Effective PubMed searches allow the clinician to remain current on the latest clinical trials, systematic reviews, and practice guidelines. PubMed continues to evolve by allowing users to create a customized experience through the My NCBI portal, new arrangements and options in search filters, and supporting scholarly projects through exportation of citations to reference managing software. Prepackaged search options available in the Clinical Queries feature also allow users to efficiently search for clinical literature. PubMed also provides information regarding the source journals themselves through the Journals in NCBI Databases link. This article provides an overview of the PubMed database's structure and features as well as strategies for conducting an effective search.

A study on PubMed search tag usage pattern: association rule mining of a full-day PubMed query log.

Science.gov (United States)

Mosa, Abu Saleh Mohammad; Yoo, Illhoi

2013-01-09

The practice of evidence-based medicine requires efficient biomedical literature search such as PubMed/MEDLINE. Retrieval performance relies highly on the efficient use of search field tags. The purpose of this study was to analyze PubMed log data in order to understand the usage pattern of search tags by the end user in PubMed/MEDLINE search. A PubMed query log file was obtained from the National Library of Medicine containing anonymous user identification, timestamp, and query text. Inconsistent records were removed from the dataset and the search tags were extracted from the query texts. A total of 2,917,159 queries were selected for this study issued by a total of 613,061 users. The analysis of frequent co-occurrences and usage patterns of the search tags was conducted using an association mining algorithm. The percentage of search tag usage was low (11.38% of the total queries) and only 2.95% of queries contained two or more tags. Three out of four users used no search tag and about two-third of them issued less than four queries. Among the queries containing at least one tagged search term, the average number of search tags was almost half of the number of total search terms. Navigational search tags are more frequently used than informational search tags. While no strong association was observed between informational and navigational tags, six (out of 19) informational tags and six (out of 29) navigational tags showed strong associations in PubMed searches. The low percentage of search tag usage implies that PubMed/MEDLINE users do not utilize the features of PubMed/MEDLINE widely or they are not aware of such features or solely depend on the high recall focused query translation by the PubMed's Automatic Term Mapping. The users need further education and interactive search application for effective use of the search tags in order to fulfill their biomedical information needs from PubMed/MEDLINE.

Mars 2020 Entry, Descent and Landing Instrumentation (MEDLI2)

Science.gov (United States)

Bose, Deepak; Wright, Henry; White, Todd; Schoenenberger, Mark; Santos, Jose; Karlgaard, Chris; Kuhl, Chris; Oishi, TOmo; Trombetta, Dominic

2016-01-01

This paper will introduce Mars Entry Descent and Landing Instrumentation (MEDLI2) on NASA's Mars2020 mission. Mars2020 is a flagship NASA mission with science and technology objectives to help answer questions about possibility of life on Mars as well as to demonstrate technologies for future human expedition. Mars2020 is scheduled for launch in 2020. MEDLI2 is a suite of instruments embedded in the heatshield and backshell thermal protection systems of Mars2020 entry vehicle. The objectives of MEDLI2 are to gather critical aerodynamics, aerothermodynamics and TPS performance data during EDL phase of the mission. MEDLI2 builds up the success of MEDLI flight instrumentation on Mars Science Laboratory mission in 2012. MEDLI instrumentation suite measured surface pressure and TPS temperature on the heatshield during MSL entry into Mars. MEDLI data has since been used for unprecedented reconstruction of aerodynamic drag, vehicle attitude, in-situ atmospheric density, aerothermal heating, transition to turbulence, in-depth TPS performance and TPS ablation. [1,2] In addition to validating predictive models, MEDLI data has highlighted extra margin available in the MSL forebody TPS, which can potentially be used to reduce vehicle parasitic mass. MEDLI2 expands the scope of instrumentation by focusing on quantities of interest not addressed in MEDLI suite. The type the sensors are expanded and their layout on the TPS modified to meet these new objectives. The paper will provide key motivation and governing requirements that drive the choice and the implementation of the new sensor suite. The implementation considerations of sensor selection, qualification, and demonstration of minimal risk to the host mission will be described. The additional challenges associated with mechanical accommodation, electrical impact, data storage and retrieval for MEDLI2 system, which extends sensors to backshell will also be described.

Med Antony Beevor i Ardennerne

DEFF Research Database (Denmark)

Christensen, Claus Bundgård

2015-01-01

Den storsælgende amerikanske historiker Antony Beevor tager i sin gennemgang af Anden Verdenskrigs slag denne gang læserne med til de sneklædte skove i Ardennerne, hvor tyskerne iværksatte deres sidste store offensiv på Vestfronten.......Den storsælgende amerikanske historiker Antony Beevor tager i sin gennemgang af Anden Verdenskrigs slag denne gang læserne med til de sneklædte skove i Ardennerne, hvor tyskerne iværksatte deres sidste store offensiv på Vestfronten....

Ud at se med Erasmus

DEFF Research Database (Denmark)

Frandsen, Pernille

2009-01-01

Få lidt luft under vingerne, kom ud at møde udenlandske kolleger og se, hvordan man også kan lave uddannelsesbibliotek. Med begejstring fortæller tre bibliotekarer om deres oplevelser i det store udland – alt sammen finansieret af Erasmus.......Få lidt luft under vingerne, kom ud at møde udenlandske kolleger og se, hvordan man også kan lave uddannelsesbibliotek. Med begejstring fortæller tre bibliotekarer om deres oplevelser i det store udland – alt sammen finansieret af Erasmus....

Ud med Freud, Marx og Lacan

DEFF Research Database (Denmark)

Clasen, Mathias

2009-01-01

Det er på høje tid, at humanister løsriver sig fra deres forældede teorier. Freud, Marx og Lacan skal erstattes med evolutionspsykologi, biologi og kognitionsvidenskab.......Det er på høje tid, at humanister løsriver sig fra deres forældede teorier. Freud, Marx og Lacan skal erstattes med evolutionspsykologi, biologi og kognitionsvidenskab....

Til julefrokost med Bjørn & Okay

DEFF Research Database (Denmark)

Smith-Sivertsen, Henrik

2012-01-01

I denne artikel vises med udgangspunkt i en beskrivelse af et specifikt arrangement med det danske danseorkester Bjørn & Okay, hvordan man optræder inden for denne særlige musiktradition. Bjørn & Okays performative udgangspunkt er, at de, trods en status som landskendt orkester med mange hits, i ...... the audience and constantly telling them what to do. At the same time he and the other musicians actively bond with the audience, both onstage and offstage, which helps building the spirit of community, which is the clear goal of the musical performance....

Washoe Med of Reno shares real patient testimonials to build hospital image.

Science.gov (United States)

2006-01-01

The three-hospital system offers the region's most comprehensive treatment programs for cancer and heart and neurological disorders, as well as pediatric urgent care and the region's only women's heart program. Washoe Med was named one of the country's Top 100 Integrated Healthcare Networks, a Hospital of Choice by the American Alliance of Healthcare Providers, and was recently recognized as one of "Nevada's Best Companies to Work For" by Nevada Business Journal. Its marketing department along with agency Estipona Vialpando Partners created a successful integrated marketing campaign to rebrand the hospital and create external and internal ad campaigns.

Selskabsloven med kommentarer

DEFF Research Database (Denmark)

Schaumburg-Müller, Peer; Werlauff, Erik

Selskabsloven med kommentarer er bibelen på området for kapitalselskaber. Den er et juridisk arbejdsredskab for praktikere, rådgivere, forskere og studerende. Bogen indeholder en komplet opdatering af kommentarerne i forhold til de mange ændringer i selskabsloven siden 1.-udgaven, men bygger i øv...

Design Optimization of the Fast Switched Chopper Dipole Magnet for the MedAustron Project

CERN Document Server

AUTHOR|(CDS)2083482; Borburgh, Jan

The MedAustron hadron therapy centre currently under construction in Wiener Neustadt, Austria, is a synchrotron based accelerator facility for cancer treatment with protons and carbon ions. The concept for such a machine first originated at the European Organization for Nuclear Research (CERN) in 1999 as the Proton-Ion Medical Machine Study (PIMMS). The first centre based on this concept was the National Centre for Oncological Treatment (CNAO) built in Italy, which treated its first patient in November 2012. The MedAustron accelerator complex consists of three particle sources, a linear accelerator, a synchrotron, an extraction line, and four irradiation rooms (1 experimental area with horizontal fixed beam, 2 fixed beam line rooms (one horizontal, and one horizontal and vertical) and a rotating gantry treatment room). It will be capable of accelerating 1H+ protons to energies of 60-250 MeV for clinical purposes, and up to 800 MeV for research purposes. It will also accelerate 12C6+ carbon ions to energies of...

Symptom attributions in patients with colorectal cancer

DEFF Research Database (Denmark)

Jensen, Line Flytkjær; Hvidberg, Line; Pedersen, Anette Fischer

2015-01-01

Størstedelen af kolorektal cancere opdages gennem patienters symptomatiske henvendelse i almen praksis. Man ved dog ikke meget om, hvordan patienter selv oplever deres symptomer. Formålet med studiet var, at undersøge om symptom attributioner er associeret med hvilket symptom man oplevede før...

Automation med pneumatiske servodrev - status og fremtid

DEFF Research Database (Denmark)

Sørensen, Paul Haase

1996-01-01

Der er råd for problemer med ulineariteter. Med de nyeste metoder kan der lineære driftsområde udvides. Men pneumatikkomponenter skal være af høj kvalitet, når positionering skal være nøjagtig....

Opfattelser af integration blandt unge med migrantbaggrund

DEFF Research Database (Denmark)

Skytte, Marianne; Bryderup, Inge

2014-01-01

I artiklen formidles analyser af otte interview med unge med migrantbaggrund. Der er fokus på de unges oplevelser og opfattelser af integration. Der er tale om komplekse processer og vekselvirkninger i forholdet mellem de samfundsmæssige kategoriseringer og individernes selvopfattelser. De unge o...

Forandringslæring med autismediagnoser?

DEFF Research Database (Denmark)

Gustafson, Kari Ingrid; Mørck, Line Lerche

2013-01-01

Artiklen drøfter en række aktuelle spørgsmål omkring læring hos børn og unge med autisme-spektrum-forstyrrelses diagnoser. Der introduceres til en social praksisteoretisk forståelse af forandringslæring, der diskuterer forandring ikke kun i relation til en persons identitet, men også aktuelle og...... potentielle forandringer, når det gælder overskridelse af binær logik i autisme versus normalitet, samt i relation til at overskride individualiserede og dualistiske problem-forståelser af fejl og mangler ved det autistiske barn. Det illustreres, hvordan disse former for dualistisk tænkning er forankret i et...... Rasmus’ ændringer i læring, selvforståelse og tilhørsforhold perspektiveres med andre ASF-diagnostiseredes læring udforsket bl.a. gennem gruppeinterviews i regi af Asperger-foreningen. Artiklen byder således på et alternativ i form af at forstå forandringslæring som overskridende læring, med langt større...

MedXViewer: an extensible web-enabled software package for medical imaging

Science.gov (United States)

Looney, P. T.; Young, K. C.; Mackenzie, Alistair; Halling-Brown, Mark D.

2014-03-01

MedXViewer (Medical eXtensible Viewer) is an application designed to allow workstation-independent, PACS-less viewing and interaction with anonymised medical images (e.g. observer studies). The application was initially implemented for use in digital mammography and tomosynthesis but the flexible software design allows it to be easily extended to other imaging modalities. Regions of interest can be identified by a user and any associated information about a mark, an image or a study can be added. The questions and settings can be easily configured depending on the need of the research allowing both ROC and FROC studies to be performed. The extensible nature of the design allows for other functionality and hanging protocols to be available for each study. Panning, windowing, zooming and moving through slices are all available while modality-specific features can be easily enabled e.g. quadrant zooming in mammographic studies. MedXViewer can integrate with a web-based image database allowing results and images to be stored centrally. The software and images can be downloaded remotely from this centralised data-store. Alternatively, the software can run without a network connection where the images and results can be encrypted and stored locally on a machine or external drive. Due to the advanced workstation-style functionality, the simple deployment on heterogeneous systems over the internet without a requirement for administrative access and the ability to utilise a centralised database, MedXViewer has been used for running remote paper-less observer studies and is capable of providing a training infrastructure and co-ordinating remote collaborative viewing sessions (e.g. cancer reviews, interesting cases).

Personer med handicap

DEFF Research Database (Denmark)

Larsen, Brian; Jonassen, Anders Bruun; Høgelund, Jan

Regeringens Arbejdsmarkedskommission kommmer medio 2009 med forslag til, hvordan den samlede arbejdsindsats varigt kan øges gennem reformer på arbejdsmarkedet. En måde det kan ske på, er ved at begrænse antallet af personer, der står uden for arbejdsmarkedet som følge af helbredsproblemer. Rappor...

PubFocus: semantic MEDLINE/PubMed citations analytics through integration of controlled biomedical dictionaries and ranking algorithm

Directory of Open Access Journals (Sweden)

Chuong Cheng-Ming

2006-10-01

Full Text Available Abstract Background Understanding research activity within any given biomedical field is important. Search outputs generated by MEDLINE/PubMed are not well classified and require lengthy manual citation analysis. Automation of citation analytics can be very useful and timesaving for both novices and experts. Results PubFocus web server automates analysis of MEDLINE/PubMed search queries by enriching them with two widely used human factor-based bibliometric indicators of publication quality: journal impact factor and volume of forward references. In addition to providing basic volumetric statistics, PubFocus also prioritizes citations and evaluates authors' impact on the field of search. PubFocus also analyses presence and occurrence of biomedical key terms within citations by utilizing controlled vocabularies. Conclusion We have developed citations' prioritisation algorithm based on journal impact factor, forward referencing volume, referencing dynamics, and author's contribution level. It can be applied either to the primary set of PubMed search results or to the subsets of these results identified through key terms from controlled biomedical vocabularies and ontologies. NCI (National Cancer Institute thesaurus and MGD (Mouse Genome Database mammalian gene orthology have been implemented for key terms analytics. PubFocus provides a scalable platform for the integration of multiple available ontology databases. PubFocus analytics can be adapted for input sources of biomedical citations other than PubMed.

Mulig forbedret behandling af kolorektal cancer med sentinel lymph node-diagnostik

DEFF Research Database (Denmark)

Burgdorf, Stefan Kobbelgaard; Eriksen, Jens Ravn; Gögenur, Ismail

2014-01-01

Possibly improved treatment of colorectal cancer by sentinel lymph node mapping Prognosis for colorectal cancer is dependent on radical surgical intervention. Chemotherapy in patients with advanced disease has improved the survival. A considerable proportion of the patients going through radical...... surgery will subsequently relapse. Adjuvant chemotherapy is reserved for patients with lymph node metastases, why undetected malignant lymph nodes will result in understaging and exclusion from the possible benefit of adjuvant chemotherapy. With sentinel lymph node mapping it may be possible to detect...

Juridiske overvejelser i forbindelse med Influence Operationer

DEFF Research Database (Denmark)

Nissen, Thomas Elkjer

2014-01-01

Kapitel 8: Juridiske overvejelser i forbindelse med influence-operationer Af Thomas Elkjer Nissen Dette kapitel fokuserer ligesom kapitel 9 på de juridiske problemstillinger, som den teknologiske udvikling har bragt med sig til væbnede konflikter; i dette kapitel er der fokus på kommunikation....... Kapitlet ser nærmere på det moderne informationsmiljø, dets betydning i moderne konflikter og den stigende anvendelse af information som magtmiddel. Herefter rettes blikket mod de juridiske overvejelser, der er forbundet med influence-operationer, bl.a. tid og rum, chefansvar, mandat og juridisk grundlag....... Afsnittet behandler desuden bl.a. jus in bello’s grundlæggende princippers indflydelse på influence-operationer....

Ukraine i fokus sammen med Georgien

DEFF Research Database (Denmark)

Fledelius, Karsten

2017-01-01

Der er god grund til at sammenligne Ukraine og Georgien, nu fokuslande for Danmark, og der er god grund til at støtte disse to eks-sovjetiske stater med i høj grad parallelle problemer.......Der er god grund til at sammenligne Ukraine og Georgien, nu fokuslande for Danmark, og der er god grund til at støtte disse to eks-sovjetiske stater med i høj grad parallelle problemer....

Adherence to Mediterranean Diet and Risk of Cancer: An Updated Systematic Review and Meta-Analysis

Science.gov (United States)

Schwingshackl, Lukas; Schwedhelm, Carolina; Galbete, Cecilia; Hoffmann, Georg

2017-01-01

The aim of the present systematic review and meta-analysis was to gain further insight into the effects of adherence to Mediterranean Diet (MedD) on risk of overall cancer mortality, risk of different types of cancer, and cancer mortality and recurrence risk in cancer survivors. Literature search was performed using the electronic databases PubMed, and Scopus until 25 August 2017. We included randomized trials (RCTs), cohort (for specific tumors only incidence cases were used) studies, and case-control studies. Study-specific risk ratios, hazard ratios, and odds ratios (RR/HR/OR) were pooled using a random effects model. Observational studies (cohort and case-control studies), and intervention trials were meta-analyzed separately. The updated review process showed 27 studies that were not included in the previous meta-analysis (total number of studies evaluated: 83 studies). An overall population of 2,130,753 subjects was included in the present update. The highest adherence score to a MedD was inversely associated with a lower risk of cancer mortality (RRcohort: 0.86, 95% CI 0.81 to 0.91, I2 = 82%; n = 14 studies), colorectal cancer (RRobservational: 0.82, 95% CI 0.75 to 0.88, I2 = 73%; n = 11 studies), breast cancer (RRRCT: 0.43, 95% CI 0.21 to 0.88, n = 1 study) (RRobservational: 0.92, 95% CI 0.87 to 0.96, I2 = 22%, n = 16 studies), gastric cancer (RRobservational: 0.72, 95% CI 0.60 to 0.86, I2 = 55%; n = 4 studies), liver cancer (RRobservational: 0.58, 95% CI 0.46 to 0.73, I2 = 0%; n = 2 studies), head and neck cancer (RRobservational: 0.49, 95% CI 0.37 to 0.66, I2 = 87%; n = 7 studies), and prostate cancer (RRobservational: 0.96, 95% CI 0.92 to 1.00, I2 = 0%; n = 6 studies). Among cancer survivors, the association between the adherence to the highest MedD category and risk of cancer mortality, and cancer recurrence was not statistically significant. Pooled analyses of individual components of the MedD revealed that the protective effects appear to be most

Adherence to Mediterranean Diet and Risk of Cancer: An Updated Systematic Review and Meta-Analysis

Directory of Open Access Journals (Sweden)

Lukas Schwingshackl

2017-09-01

Full Text Available The aim of the present systematic review and meta-analysis was to gain further insight into the effects of adherence to Mediterranean Diet (MedD on risk of overall cancer mortality, risk of different types of cancer, and cancer mortality and recurrence risk in cancer survivors. Literature search was performed using the electronic databases PubMed, and Scopus until 25 August 2017. We included randomized trials (RCTs, cohort (for specific tumors only incidence cases were used studies, and case-control studies. Study-specific risk ratios, hazard ratios, and odds ratios (RR/HR/OR were pooled using a random effects model. Observational studies (cohort and case-control studies, and intervention trials were meta-analyzed separately. The updated review process showed 27 studies that were not included in the previous meta-analysis (total number of studies evaluated: 83 studies. An overall population of 2,130,753 subjects was included in the present update. The highest adherence score to a MedD was inversely associated with a lower risk of cancer mortality (RRcohort: 0.86, 95% CI 0.81 to 0.91, I2 = 82%; n = 14 studies, colorectal cancer (RRobservational: 0.82, 95% CI 0.75 to 0.88, I2 = 73%; n = 11 studies, breast cancer (RRRCT: 0.43, 95% CI 0.21 to 0.88, n = 1 study (RRobservational: 0.92, 95% CI 0.87 to 0.96, I2 = 22%, n = 16 studies, gastric cancer (RRobservational: 0.72, 95% CI 0.60 to 0.86, I2 = 55%; n = 4 studies, liver cancer (RRobservational: 0.58, 95% CI 0.46 to 0.73, I2 = 0%; n = 2 studies, head and neck cancer (RRobservational: 0.49, 95% CI 0.37 to 0.66, I2 = 87%; n = 7 studies, and prostate cancer (RRobservational: 0.96, 95% CI 0.92 to 1.00, I2 = 0%; n = 6 studies. Among cancer survivors, the association between the adherence to the highest MedD category and risk of cancer mortality, and cancer recurrence was not statistically significant. Pooled analyses of individual components of the MedD revealed that the protective effects appear to be

Aerial Refueling Clearance Process Guide

Science.gov (United States)

2014-08-21

using multinational/bi-lateral agreements such as the ATARES Agreement, cross servicing agreements, replacement in kind agreements, Foreign Military...Lighting 8.7.8 External Paint Scheme 8.8 External Weapons/Drop Tanks 9.0 Physical /Aerodynamic Influences 9.1 Boom Clear Path To Receptacle dhkARSAG DOC...Cold Nose Sw. 8.5 External Fuel Tanks 9.0 Physical /Aerodynamic Influence R. 9.1 Probe Clear Path ie: Obstructions, Instruments etc. 9.2 Drogue Hookup

Præsentation af symptomer i almen praksis hos patienter med cancer

DEFF Research Database (Denmark)

Nielsen, Tine Nørgaard; Hansen, Rikke Pilegaard; Vedsted, Peter

2010-01-01

and prostate cancer presented diagnosis-specific symptoms (change in bowel habits, cough and bladder dysfunction) as well as more non-specific symptoms (pain, weight loss and fatigue). The GPs interpreted the symptoms as alarm symptoms in 49%, as general symptoms in 24% and as non-cancer specific symptoms...

Mulig forbedret behandling af kolorektal cancer med sentinel lymph node-diagnostik

DEFF Research Database (Denmark)

Burgdorf, Stefan Kobbelgaard; Eriksen, Jens Ravn; Gögenur, Ismail

2014-01-01

Possibly improved treatment of colorectal cancer by sentinel lymph node mapping Prognosis for colorectal cancer is dependent on radical surgical intervention. Chemotherapy in patients with advanced disease has improved the survival. A considerable proportion of the patients going through radical...... surgery will subsequently relapse. Adjuvant chemotherapy is reserved for patients with lymph node metastases, why undetected malignant lymph nodes will result in understaging and exclusion from the possible benefit of adjuvant chemotherapy. With sentinel lymph node mapping it may be possible to detect...... and resect more malignant lymph node and maybe even avoid extensive resections....

Effektivisering av arbetet med rumsbeskrivningar

OpenAIRE

Enström, Magnus

2016-01-01

För att ta byggbranschen till nästa steg i utvecklingen är BIM det naturliga steget. Iteorin tycks många av lösningarna som medföljer implementationen av BIM varaenkla att förstå och skapa, i praktiken ligger dock de tekniska lösningarna långt ifrånen full implementation i branschen. I arbetet med olika typer av beskrivningar inomett byggprojekt har utvecklingen med hjälp av BIM stått still länge. Då det inte finnsnågot vedertaget sätt att utnyttja en BIM-modells information för att fylla oli...

Fang CO2 med Aminosyrer

DEFF Research Database (Denmark)

Lerche, Benedicte Mai

2010-01-01

Med såkaldte “carbon capture-teknikker” er det muligt at rense røgen fra kulfyrede kraftværker, således at den er næsten helt fri for drivhusgassen CO2. Kunsten er at gøre processen tilstrækkeligt billig. Et lovende fangstredskab i denne proces er aminosyrer.......Med såkaldte “carbon capture-teknikker” er det muligt at rense røgen fra kulfyrede kraftværker, således at den er næsten helt fri for drivhusgassen CO2. Kunsten er at gøre processen tilstrækkeligt billig. Et lovende fangstredskab i denne proces er aminosyrer....

Mindfulness som smertehåndteringsredskab for kvinder med endometriose

DEFF Research Database (Denmark)

Jensen, Mette Kold; Vedsted-Hansen, Hanne; Hansen, Tia G. B.

2011-01-01

Endometriose er en kronisk underlivssygdom med smerter og en række afledte problemer, som ikke nødvendigvis kan behandles med lægelige tiltag. Artiklen argumenterer for, at en mindfulness-baseret tilgang med fokus på smertehåndtering kan anvendes til denne klientgruppe. I vestlig terapeutisk...... sammenhæng kan mindfulness karakteriseres som nærvær, observation og beskrivelse af sansninger uden vurdering eller reaktion. Mindfulness-træning har effekt mod andre typer stress og kroniske smerter, og artiklen opridser et koncept til anvendelse ved endometriose. Konceptet belyses med en case, hvor...

Frihet & struktur : en kvalitativ studie av skolelivskvalitet hos ungdom med Tourette syndrom

OpenAIRE

Siverts, Torstein

2005-01-01

Sammendrag. Tittel: Skolelivskvalitet hos ungdom med Tourette Syndrom Med bakgrunn i egen erfaring fra arbeid med elever med Tourette Syndrom i grunnskolen, og i studier i spesialpedagogisk teori og empiri, etterstrebes det i denne studien å utvikle økt forståelse for hva slags erfaringer fra og perspektiver på sitt skoleliv elever med denne funksjonshemmende lidelsen har. Med grunnlag i analyser av intervjuer med elever om deres erfaringer og perspektiver, har jeg prøvd å b...

Spilleregler i musikterapi med børn

DEFF Research Database (Denmark)

Holck, Ulla

2005-01-01

Artiklen gennemgår udvalgte eksempler på anvendelse af spilleregler i musikterapi med børneklientgrupper. Efter en kort introduktion af Priestleys syn på analytisk musikterapi med børn, præsenteres læseren således for en række caseeksempler fra faglitteraturen, der giver indblik i udformning og a...

Forsøg med Hi-Con altanelement

DEFF Research Database (Denmark)

Hansen, Lars Pilegaard

Denne rapport beskriver forsøg udført på Laboratoriet for Bærende Konstruktioner, Aalborg Universitet med et altanelement leveret af Hi-Con Aps, Hjallerup. Forsøgene er udført i september 2002. Forsøgene omfatter en statisk prøvning, hvor altanelementet blev belastet med sandsække og nedbøjningerne...

Rutsjende dug - breddeopgave 73 med didaktisk kommentar

DEFF Research Database (Denmark)

Jensen, Jens Højgaard

2017-01-01

Mit formål med artikelserien om breddeopgaver er - udover at gøre opmærksom på RUCs fysikuddannelse - dobbelt: Dels udvælger jeg opgaverne, så de kan have interesse som fysikproblemer i egen ret. Dels udvælger jeg dem med henblik på at kunne knytte didaktiske overvejelser til dem af interesse for...

Published Research - NCI Alliance for Nanotechnology in Cancer

Science.gov (United States)

The NCI Alliance for Nanotechnology in Cancer has published much exciting and impactful research over the years. Find here a list of all of these listed in PubMed and others across the field of Cancer Nanotechnology.

NIH Study Finds Regular Aspirin Use May Reduce Ovarian Cancer Risk

Science.gov (United States)

... Links PubMed Stem Cell Information OppNet NIDB NIH Blueprint for Neuroscience Research Institutes at NIH List of ... www.cancer.gov or call NCI's Cancer Information Service at 1-800-4-CANCER (1-800-422- ...

Digital kommunikation med den offentlige sektor

DEFF Research Database (Denmark)

Berger, Jesper Bull; Andersen, Kim Normann

til. I denne undersøgelse sættes der fokus på myndighedernes besvarelse af den digitale post. Digital post blev bl.a. etableret som et alternativ til almindelig e-mail for at det offentlige kan kommunikere med borgere og virksomheder på en sikker måde, dvs. uden at uvedkommende kan få adgang til...... følsomme oplysninger. Fokus for undersøgelsen er hvordan håndterer myndighederne besvarelserne i den digitale postkasse: svarer de på digital post og e-mail, hvor hurtigt svarer de og er svarene brugbare? Undersøgelsen medtager myndighedernes besvarelse af digital post og e-mail, dels for at kunne...... sammenligne de to digitale kanaler og for at kunne sammenligne med en tidligere undersøgelse af digital kommunikation med det offentlige. Herudover er der tidligere gennemført en undersøgelse af e-mail svar og svartider i New Zealand og Australien. De danske resultater fra e-mail undersøgelsen, men ikke...

CARING (CAncer Risk and INsulin analoGues)

DEFF Research Database (Denmark)

Linde, Jakob Starup; Karlstad, Oystein; Eriksen, Stine Aistrup

2013-01-01

=1.2), breast (RR=1.1), cervix (RR=1.3), endometrial (RR=1.4), several digestive tract (RR=1.1-1.5), kidney (RR=1.4), and bladder cancer (RR=1.1). The findings were similar for men and women, and unrelated to study design. Meta-regression analyses showed limited effect modification of body mass index......BACKGROUND: Patients suffering from diabetes mellitus (DM) may experience an increased risk of cancer; however, it is not certain whether this effect is due to diabetes per se. OBJECTIVE: To examine the association between DM and cancers by a systematic review and meta-analysis according...... to the PRISMA guidelines. DATA SOURCES: The systematic literature search includes Medline at PubMed, Embase, Cinahl, Bibliotek.dk, Cochrane library, Web of Science and SveMed+ with the search terms: "Diabetes mellitus", "Neoplasms", and "Risk of cancer". STUDY ELIGIBILITY CRITERIA: The included studies compared...

Mellem nyliberalisme og terror - Interview med Chantal Mouffe

DEFF Research Database (Denmark)

Hansen, Allan Dreyer; Sonnichsen, André

2012-01-01

Interview med Chantal Mouffe om Hegemony and Socalist Strategy, modstandere og fjender en ny multipolær verdensorden og demokrati......Interview med Chantal Mouffe om Hegemony and Socalist Strategy, modstandere og fjender en ny multipolær verdensorden og demokrati...

Effektelektronik - teknologi med energibesparelser og forbedret performance

DEFF Research Database (Denmark)

Blaabjerg, Frede

2004-01-01

Lige siden transistoren blev opfundet, har det altid været ønskeligt at kunne anvende en sådan til at styre store strømme/spændinger i elektriske systemer. Det er teknologisk også sket, først med tyristorer til styring af store effekter, men siden hen også med den bipolare transistor MOSFET, samt...

Ny viden begynder med forhindringer

DEFF Research Database (Denmark)

Johansen, Martin Blok

2017-01-01

Pædagogik og pædagogisk arbejde diskuteres typisk inden for rammerne af det at hjælpe, støtte, simplificere og kompleksitetsreducere. Hvis man ønsker at vide noget om forhindringer, modstand og vanskeligheder som pædagogiske muligheder, så er udbuddet derimod forsvindende småt. Og når sådanne...... begreber endelig tages op, så benævnes de typisk blot, men bliver sjældent defineret. Hvad menes der med modstand, vanskeligheder eller kompleksitet? Med afsæt i en kort gennemgang af eksisterende forskning på området forsøger denne artikel at give et bud på en mulig definition af begrebet forhindring...

Er konsum av melk og egg assosiert med risiko for kreft? Foreløpige resultater fra en prospektiv undersøkelse

Directory of Open Access Journals (Sweden)

Grethe Albrektsen

2009-10-01

Full Text Available  SAMMENDRAGSammenhenger mellom kreftinsidens og konsum av egg og melk er studert i en prospektiv undersøkelse avca. 50 000 personer i alderen 30-69 år. Kostholdsdataene ble samlet inn i forbindelse med andre runde avhjerte- og karundersøkelsene som ble gjennomført av Statens helseundersøkelser i Finnmark, Sogn ogFjordane og Oppland i perioden 1977-83. Gjennomsnittlig oppfølgingstid var 11,8 år. Omlag 2000 personerfikk en kreftdiagnose i løpet av oppfølgingsperioden. Insidensrate-ratioer er beregnet i en log-lineærPoissonregresjon basert på personår under risiko. Vi fant ingen sammenheng mellom total kreftinsidens ogkonsum av melk (glass pr. dag eller egg (antall pr. uke, men for spesifikke krefttyper observerte vi enkelteassosiasjoner. Det arbeides nå med mer detaljerte analyser og med internasjonal publisering av resultatene.Albrektsen G, Heuch I, Jacobsen BK, Kvåle G. Is milk and egg consumption associated with cancerrisk? Preliminary results from a prospective study. Nor J Epidemiol 1997; 7 (2: 205-208.ENGLISH SUMMARYAssociations between cancer incidence and consumption of milk and eggs were examined in a prospectivestudy of about 50,000 persons aged 30-69 years. The mean follow-up period was 11.8 years. About 2000persons were diagnosed with cancer during follow-up. Incidence rate ratios were calculated in a log-linearPoisson regression model of person-years at risk. No relations were found between overall cancer incidenceand consumption of milk (glasses per day or eggs (number per week, but some associations were observedfor specific sites. The analysis of the data is in progress and the results presented are preliminary.

Psykomotorisk behandling og wellness til personer med demens

DEFF Research Database (Denmark)

Stamp, Anne Schinkel; Frausing, Kristian Park

Rapporten evaluerer projektet Psykomotorisk behandling af personer med demens gennem fokusgruppeinterviews med deltagende studerende og personale fra deltagende centre. Samlet peges der på gavnligt udbytte for de demente beboere samt både personligt og fagligt udbytte for de deltagende studerende...

Kefir and Cancer: A Systematic Review of Literatures.

Science.gov (United States)

Rafie, Nahid; Golpour Hamedani, Sahar; Ghiasvand, Reza; Miraghajani, Maryam

2015-12-01

Some studies have suggested chemopreventive effects of kefir, a fermented milk product, on carcinogenesis. The aim of this review study was to evaluate the scientific evidence for effects of kefir on cancer prevention and treatment. We systematically searched for all relevant studies published before June 2015, using PubMed, Google scholar, Cochrane and Science Direct, SID, MedLib and Srlst databases. Relevant studies were reviewed based on systematic review (PRISMA) guidelines. From a total of 2208 papers obtained at the initial database search, 11 publications including 7 in vitro and 4 experimental studies were eligible. In vitro studies on breast, colon, skin and gastric cancers and leukemia cell lines and experimental studies on different sarcomas consistently showed beneficial effects of kefir on cancer prevention and treatment. The results of this systematic review suggest that kefir may be associated with cancer prevention and it also has beneficial effects in cancer treatment. This protection may be associated with kefir bioactive components including peptides, polysaccharides and sphingolipids.

Inkludering av ungdom med minoritetsbakgrunn i NIF-organisert idrett

Directory of Open Access Journals (Sweden)

Mari Kristin Sisjord

2014-10-01

Full Text Available Norges Idrettsforbund og Olympiske og Paralympiske Komité (NIF har en uttalt målsetting om en åpen og inkluderende idrett. Hvordan kommer dette til uttrykk i den praktiske virksomheten? Denne artikkelen, som bygger på data fra en undersøkelse om likestilling og mangfold i den organiserte idretten (NIF, retter søkelyset mot arbeid med inklusjon av ungdom med minoritetsbakgrunn på ulike organisasjonsnivå i NIF: særforbund, idrettskretser og idrettslag. Datamaterialet er kvalitative intervju med representanter fra ulike organisasjonsnivå. Resultatene viser at NIFs overordnede politikk i varierende grad nedfelles i særforbundenes virksomhet, i idrettskretsene og i idrettslagene. Av særforbundene skiller Fotballforbundet og Klatreforbundet seg ut som aktive pådrivere i arbeidet med inkludering. Mange idrettslag oppfattet slike spørsmål som lite aktuelle i sitt rekrutteringsområde. Representanter for lag som hadde erfaring med inkludering og rekruttering av minoritetsungdom, tilkjennega varierte erfaringer og synspunkter.

Professionalisme med innovativt potentiale

DEFF Research Database (Denmark)

Nielsen, Inger Marie

To teoretiske sværvægtere bliver koblet sammen i Inger Marie Larsen-Nielsen arbejdspapir om professionalisme med innovativt potentiale. De to teoretikere er læringsteoretikeren John Dewey og socialpsykologen Georg Herbert Mead, som er sat sammen i en teoretisk forståelsesramme omkring professionel...

Role of parasites in cancer.

Science.gov (United States)

Mandong, B M; Ngbea, J A; Raymond, Vhriterhire

2013-01-01

In areas of parasitic endemicity, the occurrence of cancer that is not frequent may be linked with parasitic infection. Epidemiological correlates between some parasitic infections and cancer is strong, suggesting a strong aetiological association. The common parasites associated with human cancers are schistosomiasis, malaria, liver flukes (Clonorchis sinenses, Opistorchis viverrini). To review the pathology, literature and methods of diagnosis. Literature review from peer reviewed Journals cited in PubMed and local journals. Parasites may serve as promoters of cancer in endemic areas of infection.

Comparison of PubMed and Google Scholar literature searches.

Science.gov (United States)

Anders, Michael E; Evans, Dennis P

2010-05-01

Literature searches are essential to evidence-based respiratory care. To conduct literature searches, respiratory therapists rely on search engines to retrieve information, but there is a dearth of literature on the comparative efficiencies of search engines for researching clinical questions in respiratory care. To compare PubMed and Google Scholar search results for clinical topics in respiratory care to that of a benchmark. We performed literature searches with PubMed and Google Scholar, on 3 clinical topics. In PubMed we used the Clinical Queries search filter. In Google Scholar we used the search filters in the Advanced Scholar Search option. We used the reference list of a related Cochrane Collaboration evidence-based systematic review as the benchmark for each of the search results. We calculated recall (sensitivity) and precision (positive predictive value) with 2 x 2 contingency tables. We compared the results with the chi-square test of independence and Fisher's exact test. PubMed and Google Scholar had similar recall for both overall search results (71% vs 69%) and full-text results (43% vs 51%). PubMed had better precision than Google Scholar for both overall search results (13% vs 0.07%, P PubMed searches with the Clinical Queries filter are more precise than with the Advanced Scholar Search in Google Scholar for respiratory care topics. PubMed appears to be more practical to conduct efficient, valid searches for informing evidence-based patient-care protocols, for guiding the care of individual patients, and for educational purposes.

Best, Useful and Objective Precisions for Information Retrieval of Three Search Methods in PubMed and iPubMed

Directory of Open Access Journals (Sweden)

Somayyeh Nadi Ravandi

2016-10-01

Full Text Available MEDLINE is one of the valuable sources of medical information on the Internet. Among the different open access sites of MEDLINE, PubMed is the best-known site. In 2010, iPubMed was established with an interaction-fuzzy search method for MEDLINE access. In the present work, we aimed to compare the precision of the retrieved sources (Best, Useful and Objective precision in the PubMed and iPubMed using two search methods (simple and MeSH search in PubMed and interaction-fuzzy method in iPubmed. During our semi-empirical study period, we held training workshops for 61 students of higher education to teach them Simple Search, MeSH Search, and Fuzzy-Interaction Search methods. Then, the precision of 305 searches for each method prepared by the students was calculated on the basis of Best precision, Useful precision, and Objective precision formulas. Analyses were done in SPSS version 11.5 using the Friedman and Wilcoxon Test, and three precisions obtained with the three precision formulas were studied for the three search methods. The mean precision of the interaction-fuzzy Search method was higher than that of the simple search and MeSH search for all three types of precision, i.e., Best precision, Useful precision, and Objective precision, and the Simple search method was in the next rank, and their mean precisions were significantly different (P < 0.001. The precision of the interaction-fuzzy search method in iPubmed was investigated for the first time. Also for the first time, three types of precision were evaluated in PubMed and iPubmed. The results showed that the Interaction-Fuzzy search method is more precise than using the natural language search (simple search and MeSH search, and users of this method found papers that were more related to their queries; even though search in Pubmed is useful, it is important that users apply new search methods to obtain the best results.

Cancergenetisk rådgivningsklinik. Erfaringer med genetisk udredning og rådgivning ved familiaer cancer mammae og familiaer cancer colorectalis

DEFF Research Database (Denmark)

Gerdes, A M; Rasmussen, K; Graversen, H P

1998-01-01

Five to ten percent of cases of breast cancer and colorectal cancer are familial. These families can be divided into high-risk families and moderate-risk families. Cancer in high-risk families can often be explained by dominant inheritance of a gene causing increased susceptibility to cancer. The...

MedRate: a wearable against child mortality

CERN Document Server

CERN. Geneva

2018-01-01

In humanitarian environments, when treating the main causes of child mortality, there are two key vital constants not easily measurable: the heart beat of the foetus and respiration rate of children. During the CERN Medtech:Hack, my team came up with MedRate, an inexpensive wearable able to monitor both. Collaboration is required to make MedRate a reality. Would you join us for a more fair fight against child mortality?

The MedAustron project: an example of large-scale technology transfer

CERN Multimedia

Antonella Del Rosso & Michael Benedikt

2013-01-01

In January this year, CERN’s Director-General Rolf Heuer handed over the first ion source to the MedAustron therapy centre in the town of Wiener Neustadt in the presence of the Austrian authorities. This milestone marks the beginning of the transition from the development and design phase to the commissioning of the new facility.   Handover of the ion source to MedAustron on 11 January, 2013. From left to right: Michael Benedikt (Project Leader MedAustron at CERN), Karlheinz Töchterle (Austrian Federal Minister of Science and Research), Erwin Pröll (Governor of Lower Austria), Rolf Heuer (Director-General CERN), Klaus Schneeberger (Lower Austrian State Parliament, Head of EBG MedAustron Council). The goal of the MedAustron project is the construction of an ion-therapy and research centre, based on a synchrotron accelerator complex, in Austria (for more about the technical part of the MedAustron project, click here). “MedAustron will be the first large-sca...

Arbejdspladsvurdering i små virksomheder med 1-4 ansatte

DEFF Research Database (Denmark)

Hasle, Peter; Esben, Dalskinn

En analyse af mulighederne for at gennemføre arbejdspladsvurdering i mikrovirksomheder med 1-4 ansatte.......En analyse af mulighederne for at gennemføre arbejdspladsvurdering i mikrovirksomheder med 1-4 ansatte....

PubMed Interact: an Interactive Search Application for MEDLINE/PubMed

Science.gov (United States)

Muin, Michael; Fontelo, Paul; Ackerman, Michael

2006-01-01

Online search and retrieval systems are important resources for medical literature research. Progressive Web 2.0 technologies provide opportunities to improve search strategies and user experience. Using PHP, Document Object Model (DOM) manipulation and Asynchronous JavaScript and XML (Ajax), PubMed Interact allows greater functionality so users can refine search parameters with ease and interact with the search results to retrieve and display relevant information and related articles. PMID:17238658

En definitionssandhed med modifikationer

DEFF Research Database (Denmark)

Holtermann, Jakob v. H.; Olsen, Henrik Palmer

2013-01-01

Denne artikel indgår i den debat om retskildebegrebet, der tidligere har været rejst af Jens Ravnkilde. Forfatterne påviser flere svagheder i Ravnkildes argumentation, herunder at han ignorerer hele den internationale diskussion på området, samtidig med at han baserer sit eget angiveligt nyudvikl...

Analys av nickel med ICP-MS

OpenAIRE

Wallman, Karin; Löfgren, Stefan; Sonesten, Lars; Demandt, Christian

2009-01-01

Vid en granskning av nickelhalter för perioden 1985-2007 upptäcktes ett nivåskifte i tidsserierna på flera stationer mellan 2001 och 2002. Skiftet visade sig bero på att prover innan 2002 inte korrigerades för kalciuminterferens, medan prover under åren 2002-2007 korrigerades. Syftet med denna rapport är att utreda om resultaten före 2002 i efterhand kan korrigeras för kalciuminterferensen. Från 2002 finns ett antal prover (N=347) med resultat som både är kalciumkorrigerade och som inte är de...

Tur-samspil i musikterapi med børn med svære kommunikationsvanskeligheder

DEFF Research Database (Denmark)

Holck, Ulla

2006-01-01

Tur-samspil udgør en vigtig grundsten i den tidlige sociale og kommunikative udvikling, og optræder ofte i musikterapeutiske samspil med kommunikationssvage børn. Artiklen præsenterer relevante begreber fra faglitteraturen om tur-samspil i voksendialoger (de såkaldte Konversationsanalyser), som k...

Musikterapi med kontakt- og kommunikationssvage børn

DEFF Research Database (Denmark)

Frederiksen, Britta Vinkler

2009-01-01

I artiklen beskrives, hvordan musikterapi er med til at støtte en målrettet udviklingsproces hos børn, med diagnoser som Asperger syndrom, autisme, opmærksomhedsforstyrrelser, ADHD o.lign. Musikkens kvaliteter beskrives og illustreres gennem vignetter fra terapiforløb, der alle er foregået i Klinik...

Ødelæg alt muligt med et bogstav

DEFF Research Database (Denmark)

Konzack, Lars

2017-01-01

En gang imellem griber en raptus SoMe-Danmark, og så fyldes alles feed med samme slags indhold. Senest overspringshandlede vi med hashtagget #oedelaeg1filmed1bogstav - og alle mulige afledninger af det....

Pre-Clinical and Clinical Investigation of the Impact of Obesity on Ovarian Cancer Pathogenesis

Science.gov (United States)

2015-12-01

clinical cancer drug discovery , including 10 years as a Research Assistant Professor in the Department of Surgery at Duke University Medical Center...cancer therapy. Nature chemical biology . 2015;11(1):9-15. Epub 2014/12/18. doi: 10.1038/nchembio.1712. PubMed PMID: 25517383; PubMed Central PMCID...Assistant Professor of Nutrition, a member of the Nutrition Obesity Research Center, Center for Gastrointestinal Biology and Disease, McCallister Heart

PubMed Medical Publications From Libya | Bakoush | Libyan ...

African Journals Online (AJOL)

We also used the same method to obtain data on the PubMed medical publications from Tunisia, Morocco and Yemen. Tunisia had the largest number of PubMed publications among the studied countries: 20.4 publications per million population per year and 7.2 publications per year per one billion US$ GDP. Libya had ...

Familial Gastric Cancers.

Science.gov (United States)

Setia, Namrata; Clark, Jeffrey W; Duda, Dan G; Hong, Theodore S; Kwak, Eunice L; Mullen, John T; Lauwers, Gregory Y

2015-12-01

Although the majority of gastric carcinomas are sporadic, approximately 10% show familial aggregation, and a hereditary cause is determined in 1%-3% cases. Of these, hereditary diffuse gastric cancer is the most recognized predisposition syndrome. Although rare, the less commonly known syndromes also confer a markedly increased risk for development of gastric cancer. Identification and characterization of these syndromes require a multidisciplinary effort involving oncologists, surgeons, genetic counselors, biologists, and pathologists. This article reviews the molecular genetics, clinical and pathologic features, surveillance guidelines, and preventive measures of common and less common hereditary gastric cancer predisposition syndromes. ©AlphaMed Press.

MedlinePlus FAQ: MedlinePlus and MEDLINE/PubMed

Science.gov (United States)

... What is the difference between MedlinePlus and MEDLINE/PubMed? To use the sharing features on this page, ... latest health professional articles on your topic. MEDLINE/PubMed: Is a database of professional biomedical literature Is ...

GOClonto: an ontological clustering approach for conceptualizing PubMed abstracts.

Science.gov (United States)

Zheng, Hai-Tao; Borchert, Charles; Kim, Hong-Gee

2010-02-01

Concurrent with progress in biomedical sciences, an overwhelming of textual knowledge is accumulating in the biomedical literature. PubMed is the most comprehensive database collecting and managing biomedical literature. To help researchers easily understand collections of PubMed abstracts, numerous clustering methods have been proposed to group similar abstracts based on their shared features. However, most of these methods do not explore the semantic relationships among groupings of documents, which could help better illuminate the groupings of PubMed abstracts. To address this issue, we proposed an ontological clustering method called GOClonto for conceptualizing PubMed abstracts. GOClonto uses latent semantic analysis (LSA) and gene ontology (GO) to identify key gene-related concepts and their relationships as well as allocate PubMed abstracts based on these key gene-related concepts. Based on two PubMed abstract collections, the experimental results show that GOClonto is able to identify key gene-related concepts and outperforms the STC (suffix tree clustering) algorithm, the Lingo algorithm, the Fuzzy Ants algorithm, and the clustering based TRS (tolerance rough set) algorithm. Moreover, the two ontologies generated by GOClonto show significant informative conceptual structures.

National trivselsdag med fokus på bevægelse

DEFF Research Database (Denmark)

Holt, Anne-Didde

2016-01-01

breaks”, skriver tre elever. Trivselsdagen gav ligeledes anledning til at dele de gode erfaringer, der indtil nu er udsprunget af ’Trivsel og Bevægelse i Skolen’ - P1 Morgen, P4 Fyn og TV-avisen bragte historier fra dagen på Glamsbjergskolen i Assens, mens P4 Midt og Vest besøgte Haldgård Skole i...... til at fordybe sig i, videreudvikle og vise omverdenen, hvordan der arbejdes med at fremme trivsel gennem bevægelse. Eleverne arbejdede bl.a. med at udvikle og afprøve brain breaks, som er små pauser med bevægelsesaktiviteter, der lægges ind i løbet af den stillesiddende undervisning. Formålet var...... for dem. ”Vi synes brain breaks er vigtige fordi med brain breaks får vi meget mere energi og fordi at man får et bedre forhold til sine klassekammerater, som man måske ikke snakker med så tit. Man kan holde til mere og det er vigtigt at få en pause til at tænke så derfor vil vi gerne have flere brain...

The MedAustron Project at CERN, Status Report, May 2013

CERN Document Server

Benedikt, M; Gutleber, J

2013-01-01

MedAustron is a light ion-therapy and research centre based on a synchrotron accelerator complex under construction in Austria. It is the first large-scale accelerator facility in Austria. For the implementation of the required accelerator technologies, the county of Lower Austria and the company EBG MedAustron have set up dedicated agreements with CERN. These cover the assistance of CERN for the design and manufacturing follow-up of accelerator components and training of MedAustron personnel. CERN contributed to the MedAustron construction in particular by providing domain expertise, infrastructure, and manpower in relation with the design, the tendering and procurement processes.\

Orientering og banelægning med Google Earth og Condes

DEFF Research Database (Denmark)

Jørgensen, Henrik Taarsted; Piaster, Thomas Gabriel

2011-01-01

Et e-læringsmodul på Danmarks undervisningsportal, som handler om hvordan man kan arbejde med banelægning indenfor o-løb. Med udgangspunkt i de to gratisprogrammer Google Earth og Condes lærer man gennem modulet, hvordan man indtegner poster og hvordan eleverne kan gøre det samme.......Et e-læringsmodul på Danmarks undervisningsportal, som handler om hvordan man kan arbejde med banelægning indenfor o-løb. Med udgangspunkt i de to gratisprogrammer Google Earth og Condes lærer man gennem modulet, hvordan man indtegner poster og hvordan eleverne kan gøre det samme....

Poetisk sortsyn med lys for enden

DEFF Research Database (Denmark)

Larsen, Peter Stein

2015-01-01

Ursula Andkjær Olsens digtsamling " Udgående fartøj" indledes med den følgende prægnante passage, der kan læses i sin helhed som " ugens digt" her på siden: " jeg har brugt tid på at tyde/ sprede dumpe fornemmelser / fra mit fjerne indre (...)......Ursula Andkjær Olsens digtsamling " Udgående fartøj" indledes med den følgende prægnante passage, der kan læses i sin helhed som " ugens digt" her på siden: " jeg har brugt tid på at tyde/ sprede dumpe fornemmelser / fra mit fjerne indre (...)...

At skrive med video

DEFF Research Database (Denmark)

Holmboe, Peter

2018-01-01

Det kræver særlige kompetencer at skrive en digital tekst, så modtageren kan læse og bruge den. Derfor er det vigtigt at stimulere og udvikle elevernes skrivekompetence med både viden og værktøjer. Digital skrivedidaktik præsenterer teori om skrivekompetence og digital skrivning. Derudover...

Exome sequencing identifies highly recurrent MED12 somatic mutations in breast fibroadenoma.

Science.gov (United States)

Lim, Weng Khong; Ong, Choon Kiat; Tan, Jing; Thike, Aye Aye; Ng, Cedric Chuan Young; Rajasegaran, Vikneswari; Myint, Swe Swe; Nagarajan, Sanjanaa; Nasir, Nur Diyana Md; McPherson, John R; Cutcutache, Ioana; Poore, Gregory; Tay, Su Ting; Ooi, Wei Siong; Tan, Veronique Kiak Mien; Hartman, Mikael; Ong, Kong Wee; Tan, Benita K T; Rozen, Steven G; Tan, Puay Hoon; Tan, Patrick; Teh, Bin Tean

2014-08-01

Fibroadenomas are the most common breast tumors in women under 30 (refs. 1,2). Exome sequencing of eight fibroadenomas with matching whole-blood samples revealed recurrent somatic mutations solely in MED12, which encodes a Mediator complex subunit. Targeted sequencing of an additional 90 fibroadenomas confirmed highly frequent MED12 exon 2 mutations (58/98, 59%) that are probably somatic, with 71% of mutations occurring in codon 44. Using laser capture microdissection, we show that MED12 fibroadenoma mutations are present in stromal but not epithelial mammary cells. Expression profiling of MED12-mutated and wild-type fibroadenomas revealed that MED12 mutations are associated with dysregulated estrogen signaling and extracellular matrix organization. The fibroadenoma MED12 mutation spectrum is nearly identical to that of previously reported MED12 lesions in uterine leiomyoma but not those of other tumors. Benign tumors of the breast and uterus, both of which are key target tissues of estrogen, may thus share a common genetic basis underpinned by highly frequent and specific MED12 mutations.

Further confirmation of the MED13L haploinsufficiency syndrome

NARCIS (Netherlands)

van Haelst, M.M.; Monroe, G.R.; Duran, K.J.; van Binsbergen, E.; Breur, J.M.P.J.; Giltay, J.C.; van Haaften, G.W.

MED13L haploinsufficiency syndrome has been described in two patients and is characterized by moderate intellectual disability (ID), conotruncal heart defects, facial abnormalities and hypotonia. Missense mutations in MED13L are linked to transposition of the great arteries and non-syndromal

Death, dying and informatics: misrepresenting religion on MedLine.

Science.gov (United States)

Rodríguez Del Pozo, Pablo; Fins, Joseph J

2005-07-01

The globalization of medical science carries for doctors worldwide a correlative duty to deepen their understanding of patients' cultural contexts and religious backgrounds, in order to satisfy each as a unique individual. To become better informed, practitioners may turn to MedLine, but it is unclear whether the information found there is an accurate representation of culture and religion. To test MedLine's representation of this field, we chose the topic of death and dying in the three major monotheistic religions. We searched MedLine using PubMed in order to retrieve and thematically analyze full-length scholarly journal papers or case reports dealing with religious traditions and end-of-life care. Our search consisted of a string of words that included the most common denominations of the three religions, the standard heading terms used by the National Reference Center for Bioethics Literature (NRCBL), and the Medical Subject Headings (MeSH) used by the National Library of Medicine. Eligible articles were limited to English-language papers with an abstract. We found that while a bibliographic search in MedLine on this topic produced instant results and some valuable literature, the aggregate reflected a selection bias. American writers were over-represented given the global prevalence of these religious traditions. Denominationally affiliated authors predominated in representing the Christian traditions. The Islamic tradition was under-represented. MedLine's capability to identify the most current, reliable and accurate information about purely scientific topics should not be assumed to be the same case when considering the interface of religion, culture and end-of-life care.

Hvad SKER der med drikkevandet i USA?

DEFF Research Database (Denmark)

Ramsay, Loren Mark

2017-01-01

Forskellige lande har forskellige traditioner indenfor drikkevandsbehandling. Denne beretning fra ”Water Quality Technology Conference” i USA er set med en særlig vinkel, da forfatteren er amerikansk statsborger, men har arbejdet i den danske vandbranche i mere end 25 år.......Forskellige lande har forskellige traditioner indenfor drikkevandsbehandling. Denne beretning fra ”Water Quality Technology Conference” i USA er set med en særlig vinkel, da forfatteren er amerikansk statsborger, men har arbejdet i den danske vandbranche i mere end 25 år....

Food-Dependent Exercise-Induced Anaphylaxis - Kasuistik med hydrolyseret valleprotein

DEFF Research Database (Denmark)

Junker Christensen, Morten

2013-01-01

Formål / Introduktion: Patienter med Food-Dependent Exercise-Induced Anaphylaxis (FDEIA) eller løbershock kan udvikle livstruende allergiske reaktioner (anafylaksi), når de kombinere fysisk anstrengelse med samtidig indtagelse af et normalt tolereret fødeemne - oftest hvede. Hydrolysering af prot...

Beskrivelse af næringsstofomsætning med metabolomics

DEFF Research Database (Denmark)

Hedemann, Mette Skou

2010-01-01

I et forsøg med mink med lav eller høj foderkonvertering er der blevet taget blodprøver på tre tidspunkter. Blodprøverne er blevet taget i en periode, hvor minkene er blevet fodret restriktivt (en prøve) og i en periode med ad libitum fodring (to prøver). Blodprøverne blev analyseret ved hjælp af...... fra restriktivt fodrede mink end i plasma fra ad libitum fodrede mink - betain og carnitin. Derudover er der en lang række andre metabolitter, som også findes i forskellig koncentration som endnu ikke er identificeret....

Retrieval of diagnostic and treatment studies for clinical use through PubMed and PubMed's Clinical Queries filters.

Science.gov (United States)

Lokker, Cynthia; Haynes, R Brian; Wilczynski, Nancy L; McKibbon, K Ann; Walter, Stephen D

2011-01-01

Clinical Queries filters were developed to improve the retrieval of high-quality studies in searches on clinical matters. The study objective was to determine the yield of relevant citations and physician satisfaction while searching for diagnostic and treatment studies using the Clinical Queries page of PubMed compared with searching PubMed without these filters. Forty practicing physicians, presented with standardized treatment and diagnosis questions and one question of their choosing, entered search terms which were processed in a random, blinded fashion through PubMed alone and PubMed Clinical Queries. Participants rated search retrievals for applicability to the question at hand and satisfaction. For treatment, the primary outcome of retrieval of relevant articles was not significantly different between the groups, but a higher proportion of articles from the Clinical Queries searches met methodologic criteria (p=0.049), and more articles were published in core internal medicine journals (p=0.056). For diagnosis, the filtered results returned more relevant articles (p=0.031) and fewer irrelevant articles (overall retrieval less, p=0.023); participants needed to screen fewer articles before arriving at the first relevant citation (p<0.05). Relevance was also influenced by content terms used by participants in searching. Participants varied greatly in their search performance. Clinical Queries filtered searches returned more high-quality studies, though the retrieval of relevant articles was only statistically different between the groups for diagnosis questions. Retrieving clinically important research studies from Medline is a challenging task for physicians. Methodological search filters can improve search retrieval.

Nye steder med liv og sjæl?

DEFF Research Database (Denmark)

Stender, Marie

planlæggere, der har skabt dem, udforskes stedernes tilblivelsesproces og sociale liv. Det nye sted opfattes af både beboere og professionelle som en bar mark, og mange kræfter sættes ind på at genfortrylle det med et skær af liv, identitet og historie fra start. Hånd i hånd med branding, virtuelle fora...

Spilleregler i musikterapi med voksne

DEFF Research Database (Denmark)

Holck, Ulla

2005-01-01

Artiklen gennemgår udvalgt faglitteratur, der på et overordnet plan beskriver typer af spilleregler i musikterapi med (fortrinsvis) voksne klientgrupper. Udgangspunktet er Priestleys anvendelse af begrebet, og hendes inddeling af spilleregler i forhold til forskellige teknikker gennemgås, efterfu...

Forskning i musikterapi - børn med en Autisme Spektrum Forstyrrelse

DEFF Research Database (Denmark)

Holck, Ulla

2011-01-01

Der er forskningsmæssig evidens for, at musikterapi med børn med en autisme spektrum forstyrrelse (ASF) har en signifikant effekt. Cochrane reviews påviser, at musikterapi fremmer verbal og navnlig nonverbal kommunikation hos børn med ASF. En RCT-undersøgelse viser endvidere en signifikant effekt...

Cyclin D1-AR Crosstalk: Potential Implications for Therapeutic Response in Prostate Cancer

Science.gov (United States)

2013-06-01

metastatic androgen-independent prostate cancer. Clin Cancer Res 2004; 10: 924–928. 12 Toogood PL, Harvey PJ, Repine JT, Sheehan DJ, VanderWel SN, Zhou H et...al. Discovery of a potent and selective inhibitor of cyclin-dependent kinase 4/6. J Med Chem 2005; 48: 2388–2406. 13 Fry DW, Harvey PJ, Keller PR...cyclin- dependent kinase 6 specific inhibition. J Med Chem 2006; 49: 3826–3831. 58 Lim JT, Mansukhani M, Weinstein IB. Cyclin-dependent kinase 6

Cancer epidemiology and patient recruitment for hadron therapy

International Nuclear Information System (INIS)

Engels, H.; Wambersie, A.

1999-01-01

Patient recruitment is an important issue in the feasibility study of a hadron therapy programme such as Med-AUSTRON. Data on cancer incidence in Europe, Austria, and neighbouring countries are reviewed for the most frequent tumors suitable for charged particle therapy. From these data, the numbers of potential patients suitable for MED-AUSTRON derived for each tumor site by applying the coefficients proposed in the EULIMA-1992 feasibility study. Whatever the assumptions made, a sufficient and adequate recruitment for MED-AUSTRON can be expected. However, an appropriate referring system has to be established within Austria and also in the neighbouring countries. (orig.)

Death, dying and informatics: misrepresenting religion on MedLine

Directory of Open Access Journals (Sweden)

Fins Joseph J

2005-07-01

Full Text Available Abstract Background The globalization of medical science carries for doctors worldwide a correlative duty to deepen their understanding of patients' cultural contexts and religious backgrounds, in order to satisfy each as a unique individual. To become better informed, practitioners may turn to MedLine, but it is unclear whether the information found there is an accurate representation of culture and religion. To test MedLine's representation of this field, we chose the topic of death and dying in the three major monotheistic religions. Methods We searched MedLine using PubMed in order to retrieve and thematically analyze full-length scholarly journal papers or case reports dealing with religious traditions and end-of-life care. Our search consisted of a string of words that included the most common denominations of the three religions, the standard heading terms used by the National Reference Center for Bioethics Literature (NRCBL, and the Medical Subject Headings (MeSH used by the National Library of Medicine. Eligible articles were limited to English-language papers with an abstract. Results We found that while a bibliographic search in MedLine on this topic produced instant results and some valuable literature, the aggregate reflected a selection bias. American writers were over-represented given the global prevalence of these religious traditions. Denominationally affiliated authors predominated in representing the Christian traditions. The Islamic tradition was under-represented. Conclusion MedLine's capability to identify the most current, reliable and accurate information about purely scientific topics should not be assumed to be the same case when considering the interface of religion, culture and end-of-life care.

Farlig sex med engle

DEFF Research Database (Denmark)

Mejrup, Kristian

2013-01-01

De fleste af os tænker ikke på engle som kønnede væsner med en seksualitet, og selv om vi er i stand til at acceptere engle i alle mulige afskygninger, fra juletræets tyksakker i glitrende guld til frygtindgydende skikkelser i de bibelske skrifter, så er vi tilbøjelig til at ignorere spørgsmålet ...

Standardized Technical Data Survey (STDS) for Aerial Refueling

Science.gov (United States)

2016-09-06

enter text. c Distance (from nozzle tip) where measured (Inches) Click here to enter text. d Provide a fuel flow versus pressure curve for all pumping ...AUTHORIZED FUELS 9. MAXIMUM FUEL ONLOAD RATE (WHERE MEASURED) Ref. 2 (ARSAG Doc 03-00-03R) 10. MAXIMUM RATE OF FUEL DUMP (Optional) 11. FUEL VENT CAPABILITY...tank and all tanks filling. ☐Attached to Survey ☐ Not Available a Maximum rate of fuel dump (GPM) Click here to enter text. a Has the vent be certified

Efficacy and Safety of Pomegranate Medicinal Products for Cancer

OpenAIRE

Vlachojannis, Christian; Zimmermann, Benno F.; Chrubasik-Hausmann, Sigrun

2015-01-01

Preclinical in vitro and in vivo studies demonstrate potent effects of pomegranate preparations in cancer cell lines and animal models with chemically induced cancers. We have carried out one systematic review of the effectiveness of pomegranate products in the treatment of cancer and another on their safety. The PubMed search provided 162 references for pomegranate and cancer and 122 references for pomegranate and safety/toxicity. We identified 4 clinical studies investigating 3 pomegranate ...

Hvad skal vi med Trump-satire?

DEFF Research Database (Denmark)

Møller, Mette

2017-01-01

Trump-satire er et stort hit, og særligt en lang række satiriske videohilsner til Trump fra lande verden over får folk til at trække på smilebåndet. Men hvorfor er det så sjovt at gøre grin med Trump, og hvad kan vi bruge den politiske humor til?......Trump-satire er et stort hit, og særligt en lang række satiriske videohilsner til Trump fra lande verden over får folk til at trække på smilebåndet. Men hvorfor er det så sjovt at gøre grin med Trump, og hvad kan vi bruge den politiske humor til?...

Ion Sources for MedAustron

CERN Document Server

Lettry, J; Wallner, J; Sargsyan, E; CERN. Geneva. BE Department

2010-01-01

The MedAustron Ion therapy center will be constructed in Wiener Neustadt (Austria) in the vicinity of Vienna. Its accelerator complex consists of four ion sources, a linear accelerator, a synchrotron and a beam delivery system to the three medical treatment rooms and to the research irradiation room. The ion sources shall deliver beams of H31+, C4+ and light ions with utmost reliability and stability. This paper describes the features of the ion sources presently planned for the MedAustron facility; such as ion source main parameters, gas injection, temperature control and cooling systems. A dedicated beam diagnostics technique is proposed in order to characterize ECR ions beams; in the first drift region after the ion source, a fraction of the mixed beam is selected via moveable aperture. With standard beam diagnostics, we then aim to produce position-dependant observables such as ion-current density, beam energy distribution and emittance for each charge states to be compared to simulations of ECR e-heating...

Muscle dysfunction in cancer patients

DEFF Research Database (Denmark)

Christensen, Jesper Frank; Jones, L W; Andersen, J L

2014-01-01

dysfunction in cancer patients lies in the correlation to vital clinical end points such as cancer-specific and all-cause mortality, therapy complications and quality of life (QoL). Such associations strongly emphasize the need for effective therapeutic countermeasures to be developed and implemented...... implications of muscle dysfunction in cancer patients. The efficacy of exercise training to prevent and/or mitigate cancer-related muscle dysfunction is also discussed. DESIGN: We identified 194 studies examining muscular outcomes in cancer patients by searching PubMed and EMBASE databases. RESULTS: Muscle...... dysfunction is evident across all stages of the cancer trajectory. The causes of cancer-related muscle dysfunction are complex, but may involve a wide range of tumor-, therapy- and/or lifestyle-related factors, depending on the clinical setting of the individual patient. The main importance of muscle...

Pepducin Based Intervention of Breast Cancer Invasion

Science.gov (United States)

2006-08-01

Metalloprotease-1 Receptor that Promotes Invasion and Tumorigenesis of Breast Cancer Cells. Cell 120, 303-313. (6) Arribas , J. (2005) Matrix Metalloproteases...promotes invasion and tumorigenesis of breast cancer cells. Cell 2005;120:303–13. 6. Arribas J. Matrix metalloproteases and tumor inva- sion. N Engl J Med...to ala - provide a model for more aggressive, tamoxifen-insen- nine. The F43A PAR1 mutant does not transduce a sig- sitive, breast cancers. MDA-MB-231

Hovedpointer fra telefon survey med D&I kandidater og aftagere

DEFF Research Database (Denmark)

Brodersen, Søsser; Lindegaard, Hanne

2010-01-01

Som en anden fase i D&I evalueringen gennemførtes en telefon survey med alle færdige D&I kandidater (i perioden september til november 2009). Formålet med denne telefon survey var at kortlægge kandidaternes karriereforløb: mønstrer, entre på arbejdsmarkedet og hvor søger de job, beskæftigelsesmøn......Som en anden fase i D&I evalueringen gennemførtes en telefon survey med alle færdige D&I kandidater (i perioden september til november 2009). Formålet med denne telefon survey var at kortlægge kandidaternes karriereforløb: mønstrer, entre på arbejdsmarkedet og hvor søger de job......, beskæftigelsesmønstrer samt hvilke kompetencer de mener at have anvendt og ikke anvendt fra studiet i deres job. Telefon survey formen blev valgt for dermed at få muligheden for at få nogle kvantitative informationer frem. I alt blev 72 D&I kandidater interviewet ud af 78 mulige, dvs. vi opnåede en svarprocent på 92......,3 % . Spørgsmålene var forberedt på forhånd således at kandidaterne blev stillet de samme spørgsmål. Derudover gennemførtes en telefon survey med 14 aftagere af D&I kandidater (identificeret gennem telefon surveyen med kandidaterne, således at de repræsenterede store virksomheder, mindre virksomheder...

Software-Enabled Distributed Network Governance: The PopMedNet Experience.

Science.gov (United States)

Davies, Melanie; Erickson, Kyle; Wyner, Zachary; Malenfant, Jessica; Rosen, Rob; Brown, Jeffrey

2016-01-01

The expanded availability of electronic health information has led to increased interest in distributed health data research networks. The distributed research network model leaves data with and under the control of the data holder. Data holders, network coordinating centers, and researchers have distinct needs and challenges within this model. The concerns of network stakeholders are addressed in the design and governance models of the PopMedNet software platform. PopMedNet features include distributed querying, customizable workflows, and auditing and search capabilities. Its flexible role-based access control system enables the enforcement of varying governance policies. Four case studies describe how PopMedNet is used to enforce network governance models. Trust is an essential component of a distributed research network and must be built before data partners may be willing to participate further. The complexity of the PopMedNet system must be managed as networks grow and new data, analytic methods, and querying approaches are developed. The PopMedNet software platform supports a variety of network structures, governance models, and research activities through customizable features designed to meet the needs of network stakeholders.

Penile Cancer Presenting With Acute Urinary Retantion: Case Report

Directory of Open Access Journals (Sweden)

Ercan KAZAN

2015-06-01

Full Text Available Penile cancer is a rare malignancy in our country. Phimosis, , poor hygiene and smoking are major risk factors for penile cancer. Penile cancer in men have a strong correlation with human papilloma virus (HPV infection. Penile cancer is rare in circumcised men, particularly if they are circumcised as newborns. Penile cancer is usually asymptomatic and physical examination is essential for diagnosis. We report a case of penile cancer whose first symptom was acute urinary retention (AUR and review of the literature. [J Contemp Med 2015; 5(2.000: 131-134

Å forske med kunsten kollaborativt i en fortellerforestillingsproduksjon

Directory of Open Access Journals (Sweden)

Mette Bøe Lyngstad

2018-03-01

Full Text Available I denne artikkelen viser forskerne, som også er fortellere, hvordan de i utviklingen av sin egen fortellerforestilling forsket med kunsten. Artikkelforfatterne forsøker å vise en selvrefleksivitet og metodologisk bevissthet gjennom hele kunstproduksjonen. De undersøker hvordan en gjennom å forske med kunsten kollaborativt kan koble historiske fakta, fiksjonsfortelling og livsfortelling i en kunstproduksjon. Forskningsartikkelen tar for seg kunstproduksjonens ulike faser som brainstormfase, innsamlingsfase, fortellertekniske fase og utforskingsfase i scenerommet.

Mediator Subunit Med28 Is Essential for Mouse Peri-Implantation Development and Pluripotency.

Directory of Open Access Journals (Sweden)

Lin Li

Full Text Available The multi-subunit mammalian Mediator complex acts as an integrator of transcriptional regulation by RNA Polymerase II, and has emerged as a master coordinator of development and cell fate determination. We previously identified the Mediator subunit, MED28, as a cytosolic binding partner of merlin, the Neurofibromatosis 2 (NF2 tumor suppressor, and thus MED28 is distinct in having a cytosolic role as an NF2 interacting protein as well as a nuclear role as a Mediator complex subunit. Although limited in vitro studies have been performed on MED28, its in vivo function remains unknown. Employing a knockout mouse model, we describe for the first time the requirement for Med28 in the developing mouse embryo. Med28-deficiency causes peri-implantation lethality resulting from the loss of pluripotency of the inner cell mass accompanied by reduced expression of key pluripotency transcription factors Oct4 and Nanog. Further, overexpression of Med28 in mouse embryonic fibroblasts enhances the efficiency of their reprogramming to pluripotency. Cre-mediated inactivation of Med28 in induced pluripotent stem cells shows that Med28 is required for their survival. Intriguingly, heterozygous loss of Med28 results in differentiation of induced pluripotent stem cells into extraembryonic trophectoderm and primitive endoderm lineages. Our findings document the essential role of Med28 in the developing embryo as well as in acquisition and maintenance of pluripotency during reprogramming.

Graduating med-peds residents' interest in part-time employment.

Science.gov (United States)

Fix, Amy L; Kaelber, David C; Melgar, Thomas A; Chamberlain, John; Cull, William; Robbins, Brett W

2011-01-01

As part-time work is becoming more popular among the primary care specialties, we examined the demographic descriptors of med-peds residents seeking and finding part-time employment upon completion of residency training. As part of the 2006 annual American Academy of Pediatrics (AAP) Graduating Med-Peds Residents Survey, we surveyed the graduating residents of all med-peds programs about their interest in and plans for part-time employment. A total of 199 (60%) of the residents responded. Of the resident respondents applying for nonfellowship jobs, 19% sought part-time positions and 10% actually accepted a part-time position. Female residents were significantly more likely than male residents to apply for part-time jobs (26% vs. 7%, P = .034). Sixty percent of female residents immediately seeking work and 58% of those going on to fellowship reported an interest in arranging a part-time or reduced-hours position at some point in the next 5 years. Part-time employment among med-peds residents applying for nonfellowship positions after graduation is similar to the current incidence of part-time employment in other fields of primary care. A much higher percentage of med-peds residents are interested in arranging part-time work within 5 years after graduation. This strong interest in part-time work has many implications for the primary care workforce. Copyright © 2011 Academic Pediatric Association. Published by Elsevier Inc. All rights reserved.

Time-dependent migration of citations through PubMed and OvidSP subsets: a study on a series of simultaneous PubMed and OvidSP searches.

Science.gov (United States)

Boeker, Martin; Vach, Werner; Motschall, Edith

2013-01-01

To quantitatively describe (1) differences between search results derived at consecutive time points with the PubMed and OvidSP literature search interfaces over a five day interval, and (2) the migration of citations through different subsets to estimate the timeliness of OvidSP. PubMed-Identifiers (PMIDs) of the following subsets were retrieved from PubMed and OvidSP simultaneously (within 8 h) at 11 days in March and April 2010 including 5 consecutive days: as supplied by publisher, in process, PubMed not MEDLINE, and OLDMEDLINE. Search results were compared for difference and intersection sets. The migration of citations on individual level was determined by comparison of corresponding sets over several days. The "in process" set was stable with about 446,000 - 452,000 citations; a small fraction of up to 3 % of the total subsets were in PubMed only and OvidSP only subsets. About 96 % of the ca. 10,500 citations in the OvidSP only subset migrated within 2 days out of the "in process" subset. The database of OvidSP is updated within a period of two days.

Surrogacy of progression free survival for overall survival in metastatic breast cancer studies: Meta-analyses of published studies.

Science.gov (United States)

Kundu, Madan G; Acharyya, Suddhasatta

2017-02-01

PFS is often used as a surrogate endpoint for OS in metastatic breast cancer studies. We have evaluated the association of treatment effect on PFS with significant HR OS (and how this association is affected by other factors) in published prospective metastatic breast cancer studies. A systematic literature search in PubMed identified prospective metastatic breast cancer studies. Treatment effects on PFS were determined using hazard ratio (HR PFS ), increase in median PFS (ΔMED PFS ) and % increase in median PFS (%ΔMED PFS ). Diagnostic accuracy of PFS measures (HR PFS , ΔMED PFS and %ΔMED PFS ) in predicting significant HR OS was assessed using receiver operating characteristic (ROC) curves and classification tree approach (CART). Seventy-four cases (i.e., treatment to control comparisons) from 65 individual publications were identified for the analyses. Of these, 16 cases reported significant treatment effect on HR OS at 5% level of significance. Median number of deaths reported in these cases were 153. Area under the ROC curve (AUC) for diagnostic measures as HR PFS , ΔMED PFS and %ΔMED PFS were 0.69, 0.70 and 0.75, respectively. Classification tree results identified %ΔMED PFS and number of deaths as diagnostic measure for significant HR OS . Only 7.9% (3/39) cases with ΔMED PFS shorter than 48.27% reported significant HR OS . There were 7 cases with ΔMED PFS of 48.27% or more and number of deaths reported as 227 or more - of these 5 cases reported significant HR OS . %ΔMED PFS was found to be a better diagnostic measure for predicting significant HR OS . Our analysis results also suggest that consideration of total number of deaths may further improve its diagnostic performance. Based on our study results, the studies with 50% improvement in median PFS are more likely to produce significant HR OS if the total number of OS events at the time of analysis is 227 or more. Copyright © 2016 Elsevier Inc. All rights reserved.

Diet and lung cancer

DEFF Research Database (Denmark)

Fabricius, P; Lange, Peter

2003-01-01

Lung cancer is the leading cause of cancer-related deaths worldwide. While cigarette smoking is of key importance, factors such as diet also play a role in the development of lung cancer. MedLine and Embase were searched with diet and lung cancer as the key words. Recently published reviews...... and large well designed original articles were preferred to form the basis for the present article. A diet rich in fruit and vegetables reduces the incidence of lung cancer by approximately 25%. The reduction is of the same magnitude in current smokers, ex-smokers and never smokers. Supplementation...... with vitamins A, C and E and beta-carotene offers no protection against the development of lung cancer. On the contrary, beta-carotene supplementation has, in two major randomised intervention trials, resulted in an increased mortality. Smoking remains the leading cause of lung cancer. The adverse effects...

Jokar et al., Afr J Tradit Complement Altern Med. (2016) 13(1):40-44 ...

African Journals Online (AJOL)

PROF ADEWUNMI

Jokar et al., Afr J Tradit Complement Altern Med. ... Shiraz- Iran.3Department of Obstetrics and Gynecology, School of Medicine and maternal- fetal ..... Ann Intern Med 2001; 135(5):344–51. 7. ... Clin Geriatr Med.2008; ... Indian J. Med Res.

Susceptibility of MED-Q1 and MED-Q3 Biotypes of Bemisia tabaci (Hemiptera: Aleyrodidae) Populations to Essential and Seed Oils.

Science.gov (United States)

Samuel Fogné, Drabo; Olivier, Gnankine; Bassolé, Imael H N; Nébié, Roger Charles; Laurence, Mouton

2017-06-01

Bemisia tabaci (Gennadius) (Hemiptera: Aleyrodidae) is a major pest of many agricultural and ornamental crops in tropical and subtropical regions causing damages that result in important economic losses. Insecticides are commonly used in greenhouses or fields to control B. tabaci populations leading to rapid evolution of resistance that render treatments inefficient. Therefore, and for environmental and human health concerns, other approaches must be developed for this pest management. In the present study, we compare, using the leaf dip method, the toxicity of three essential oils (Cymbopogon citratus, Ocimum americanum, and Hyptis spicigera) and three seed oils (Lannea microcarpa, Lannea acida, and Carapa procera) with three chemical insecticides (acetamiprid, deltamethrin, and chlorpyrifos-ethyl) on adults. Two B. tabaci biotypes (MED-Q1 and MED-Q3) belonging to the Mediterranean species and collected in Burkina Faso were used. Essential oils were analyzed by gas chromatography-mass spectrometry and gas chromatography-flame ionization detector. We showed that these two biotypes have different levels of resistance to the three insecticides, MED-Q3 being more sensitive than MED-Q1. Moreover, they differ in the frequency of resistance alleles to insecticides, especially for organophosphates, as these alleles are almost fixed in MED-Q1. On the other hand, the two biotypes prove to be more susceptible to the plant extracts than to insecticides except for chlorpyrifos-ethyl, with essential oils that showed the highest insecticidal activities. Monoterpenes content were the most abundant and showed the highest insecticidal activities. Our results indicated that essential oils, but also seed oils, have the potential to constitute an alternative strategy of pest management. © The Authors 2017. Published by Oxford University Press on behalf of Entomological Society of America. All rights reserved. For Permissions, please email: journals.permissions@oup.com.

Afkølingstid - breddeopgaver 45-46 med didaktisk kommentar

DEFF Research Database (Denmark)

Jensen, Jens Højgaard

2011-01-01

Mit formål med artikelserien om breddeopgaver er – udover at gøre opmærksom på RUCs fysikuddannelse – dobbelt: Dels udvælger jeg opgaverne, så de kan have interesse som fysikproblemer i egen ret. Dels udvælger jeg dem med henblik på at kunne knytte didaktiske overvejelser til dem af interesse...

What Facilitates "Patient Empowerment" in Cancer Patients During Follow-Up

DEFF Research Database (Denmark)

Jørgensen, Clara R; Thomsen, Thora G; Ross, Lone

2018-01-01

Empowerment is a concept of growing importance in cancer care, but little is known about cancer patients' experiences of empowerment during follow-up. To explore this area, a qualitative systematic literature review was conducted in PubMed, CINAHL, and PsycINFO. A total of 2,292 papers were...

Searching PubMed for molecular epidemiology studies: the case of chromosome aberrations

DEFF Research Database (Denmark)

Ugolini, Donatella; Neri, Monica; Knudsen, Lisbeth E

2006-01-01

to environmental pollutants. The search, done on the PubMed/MedLine database, was based on a strategy combining descriptors listed in the PubMed Medical Subject Headings (MeSH) Thesaurus and other available tools (free text or phrase search tools). 178 articles were retrieved by searching the period from January 1...

A review of scientific papers about head and neck cancers

Energy Technology Data Exchange (ETDEWEB)

Paoli, Severo de; Fonseca, Adenilson de Souza da; Paoli, Flavia de; Geller, Mauro [Centro Universitario Serra dos Orgaos, Teresopolis, RJ (Brazil)]. E-mail: severodepaoli@gmail.com; Presta, Giuseppe Antonio [Universidade Federal do Estado do Rio de Janeiro (UNIRIO), RJ (Brazil); Santos-Filho, Sebastiao David; Bernardo-Filho, Mario [Universidade do Estado do Rio de Janeiro (UERJ), RJ (Brazil). Inst. de Biologia Roberto Alcantara Gomes. Dept. de Biofisica e Biometria

2008-12-15

Head and neck cancer is one of the 10 most frequent cancers worldwide, with an estimated 500000 new cases diagnosed annually. Treatment of head and neck cancers require a multidisciplinary approach due their complexity and the functional and esthetic alterations that cancer can cause. The interest of the scientific community in a specific subject can be evaluated by analyzing of the number and the quality of published papers on the topic. The information obtained from PubMed (www.ncbi.nlm.nih.gov/sites/entrez) has been used as a tool in various publications to aid the evaluation of the scientific interest in specific research areas The aim of this work is to evaluate, using PubMed, the scientific interest in studies of head and neck cancer treatments such as radiotherapy, chemotherapy and surgery. The searches were performed on PubMed for publications from the period of 1949 to 2008 using the search terms 'head and neck cancer' and 'surgery' or 'radiotherapy' or 'chemotherapy'. The number of publications per year was determined in each search. The percentage of publications was also calculated for each subject in each year. An interest factor in a subject (IFS) was also determined. The number of publications was higher for surgery than chemotherapy or radiotherapy. The calculated 1964 IFS for surgery was 14.79, 12.74 for radiotherapy, and 19.58 for chemotherapy. The 1995 IFS for surgery was 1.99, 2.09 for radiotherapy, and 2.08 for chemotherapy. The relation obtained for 1995 was maintained in the subsequent years. There are more publications related to surgical treatment for head and neck cancer when compared with radiotherapy and chemotherapy. Moreover, in the recent years there has an increased interest in treatments utilizing chemotherapy, or this associated to radiotherapy. (author)

A review of scientific papers about head and neck cancers

International Nuclear Information System (INIS)

Paoli, Severo de; Fonseca, Adenilson de Souza da; Paoli, Flavia de; Geller, Mauro; Presta, Giuseppe Antonio; Santos-Filho, Sebastiao David; Bernardo-Filho, Mario

2008-01-01

Head and neck cancer is one of the 10 most frequent cancers worldwide, with an estimated 500000 new cases diagnosed annually. Treatment of head and neck cancers require a multidisciplinary approach due their complexity and the functional and esthetic alterations that cancer can cause. The interest of the scientific community in a specific subject can be evaluated by analyzing of the number and the quality of published papers on the topic. The information obtained from PubMed (www.ncbi.nlm.nih.gov/sites/entrez) has been used as a tool in various publications to aid the evaluation of the scientific interest in specific research areas The aim of this work is to evaluate, using PubMed, the scientific interest in studies of head and neck cancer treatments such as radiotherapy, chemotherapy and surgery. The searches were performed on PubMed for publications from the period of 1949 to 2008 using the search terms 'head and neck cancer' and 'surgery' or 'radiotherapy' or 'chemotherapy'. The number of publications per year was determined in each search. The percentage of publications was also calculated for each subject in each year. An interest factor in a subject (IFS) was also determined. The number of publications was higher for surgery than chemotherapy or radiotherapy. The calculated 1964 IFS for surgery was 14.79, 12.74 for radiotherapy, and 19.58 for chemotherapy. The 1995 IFS for surgery was 1.99, 2.09 for radiotherapy, and 2.08 for chemotherapy. The relation obtained for 1995 was maintained in the subsequent years. There are more publications related to surgical treatment for head and neck cancer when compared with radiotherapy and chemotherapy. Moreover, in the recent years there has an increased interest in treatments utilizing chemotherapy, or this associated to radiotherapy. (author)

Annexin A2 and cancer

DEFF Research Database (Denmark)

Christensen, Maria V; Høgdall, Claus K; Jochumsen, Kirsten M

2018-01-01

Annexin A2 is a 36-kDa protein interfering with multiple cellular processes especially in cancer progression. The present review aimed to show the relations between Annexin A2 and cancer. A systematic search for studies investigating cancer and Annexin A2 expression was conducted using Pub......Med. Acute lymphoblastic leukaemia, acute promyelocytic leukaemia, clear cell renal cell carcinoma, breast, cervical, colorectal, endometrial, gastric cancer, glioblastoma, hepatocellular carcinoma, lung, multiple myeloma, oesophageal squamous cell carcinoma, ovarian cancer, pancreatic duct adenocarcinoma......, prostate cancer and urothelial carcinoma were evaluated. Annexin A2 expression correlates with resistance to treatment, binding to the bone marrow, histological grade and type, TNM-stage and shortened overall survival. The regulation of Annexin A2 is of interest due to its potential as target for a more...

Prognostic role of lncRNA TUG1 for cancer outcome: Evidence from 840 cancer patients.

Science.gov (United States)

Liu, Jia; Lin, Jieru; Li, Yingqi; Zhang, Yunyuan; Chen, Xian

2017-07-25

LncRNA TUG1 has been demonstrated to be aberrantly expressed in several types of cancer and maybe serve as a prognostic marker for cancer patients. However, most individual studies have been limited by small sample sizes and controversial results. Therefore, this meta analysis was conducted to analyze available data to delineate the potential clinical application of lncRNA TUG1 on cancer prognosis, lymph node metastasis and tumor progression. Up to February 20, 2017, literature collections were conducted by comprehensive searching electronic databases, including Cochrane Library, PubMed, Embase, BioMed Central, Springer, ScienceDirect, ISI Web of Knowledge, together with three Chinese databases. The hazard ratios (HR) with 95% confidence interval (95% CI) were calculated to assess the strength of the association. Eight studies with a total of 840 cancer patients were included in the present meta analysis. The results indicated that elevated lncRNA TUG1 significantly predicted unfavorable overall survival (OS) (HR = 2.06, 95% CI: 1.23-3.45, P = 0.006), but failed to show incline to lymph node metastasis (HR: 1.16, 95% CI: 0.82-1.62, P = 0.40) and disease progression (III/IV vs. I/II: HR 1.16, 95% CI: 0.74-1.81, P = 0.52). In stratified analyses, a significantly unfavorable OS associated with elevated lncRNA TUG1 was observed in both bladder cancer (HR = 2.98, 95% CI: 1.84-4.83, P TUG1 was an independent prognostic biomarker for unfavorable OS but may not susceptible to lymph node metastasis and tumor progression in cancer patients.

Ion sources for MedAustron

International Nuclear Information System (INIS)

Lettry, J.; Penescu, L.; Wallner, J.; Sargsyan, E.

2010-01-01

The MedAustron Ion therapy center will be constructed in Wiener Neustadt (Austria) in the vicinity of Vienna. Its accelerator complex consists of four ion sources, a linear accelerator, a synchrotron, and a beam delivery system to the three medical treatment rooms and to the research irradiation room. The ion sources shall deliver beams of H 3 1+ , C 4+ , and light ions with utmost reliability and stability. This paper describes the features of the ion sources presently planned for the MedAustron facility, such as ion source main parameters, gas injection, temperature control, and cooling systems. A dedicated beam diagnostics technique is proposed in order to characterize electron cyclotron resonance (ECR) ion beams; in the first drift region after the ion source, a fraction of the mixed beam is selected via moveable aperture. With standard beam diagnostics, we then aim to produce position-dependant observables such as ion-current density, beam energy distribution, and emittance for each charge states to be compared to simulations of ECR e-heating, plasma simulation, beam formation, and transport.

MedAustron board visits CERN

CERN Multimedia

CERN Bulletin

On 14 October, the board of EBG MedAustron, which is overseeing the construction of Austria’s hadron therapy centre, visited CERN. The visit recognized the relationship of shared knowledge, technology and training between CERN and MedAustron.   Normal.dotm 0 0 1 17 98 cern 1 1 120 12.0 0 false 18 pt 18 pt 0 0 false false false /* Style Definitions */ table.MsoNormalTable {mso-style-name:"Table Normal"; mso-tstyle-rowband-size:0; mso-tstyle-colband-size:0; mso-style-noshow:yes; mso-style-parent:""; mso-padding-alt:0cm 5.4pt 0cm 5.4pt; mso-para-margin-top:0cm; mso-para-margin-right:0cm; mso-para-margin-bottom:10.0pt; mso-para-margin-left:0cm; line-height:115%; mso-pagination:widow-orphan; font-size:12.0pt; font-family:"Times New Roman"; mso-ascii-font-family:Calibri; mso-ascii-theme-font:minor-latin; mso-fareast-font-family:"Times New Roman"; mso-fareast-theme-font:minor-fareast; mso-hansi-font-family:Calibri; mso-hansi-theme-font:minor-latin;} ...

Diagnostic Imaging of Lung Cancer

Directory of Open Access Journals (Sweden)

Kemal Kara

2012-12-01

Full Text Available Lung cancer is the most common cause of cancer related death in men and women. It is frequently seen among men than in women and male-female ratio is 1.5:1. Common epidemiological factors that increase risk of lung cancer is smoking. Early age to start smoking, high number of smoking cigarettes per a day and depth of inhalation increase risk of lung cancer. 25% of patients with lung cancer are nonsmokers that passively exposed to cigarette smoke. Occupational exposure to substances such as asbestos, arsenic, nickel, beryllium, mustard gas increases the risk of lung cancer. The well defined risk factor is exposure to asbestos. In addition advanced age, diffuse pulmonary fibrosis, chronic obstructive pulmonary disease (COPD and genetic predisposition are the risk factors that increases lung cancer. [TAF Prev Med Bull 2012; 11(6.000: 749-756

MED, COMP, multilayered and NEIN: an overview of multiple epiphyseal dysplasia

Energy Technology Data Exchange (ETDEWEB)

Lachman, Ralph S. [International Skeletal Dysplasia Registry, UCLA School of Medicine, Radiological Services, Department of Pediatrics, Los Angeles, CA (United States); International Skeletal Dysplasia Registry, Los Angeles, CA (United States); Krakow, Deborah; Cohn, Daniel H.; Rimoin, David L. [International Skeletal Dysplasia Registry, UCLA School of Medicine, Radiological Services, Department of Pediatrics, Los Angeles, CA (United States)

2005-02-01

This overview covers the group of disorders that presents radiographically as multiple epiphyseal dysplasia (MED). The disorders include ''classic MED'' (Ribbing and Fairbank types): MED that is caused by mutations in the cartilage oligomeric matrix protein (COMP), type IX collagen, and matrilin 3 genes (MATN3); and MED with multilayered patella, brachydactyly, and clubbed feet resultant from mutations in gene defect diastrophic dysplasia (DTDST). The recently identified gene/molecular abnormalities in these disorders have made more exact identification possible in many cases, although clinical testing is not always available. However, there are specific radiographic findings that allow the accurate diagnosis to be made, thus potentially guiding which molecular defect(s) should be investigated. The modes of inheritance of these distinct MED conditions are not identical. When a specific diagnosis is made, proper genetic counseling as well as prognostication, management issues and complications can be delineated to the patient and family. This review will include the mechanics of diagnostic and molecular triage for these disorders. (orig.)

The inclusion of an online journal in PubMed central - a difficult path.

Science.gov (United States)

Grech, Victor

2016-01-01

The indexing of a journal in a prominent database (such as PubMed) is an important imprimatur. Journals accepted for inclusion in PubMed Central (PMC) are automatically indexed in PubMed but must provide the entire contents of their publications as XML-tagged (Extensible Markup Language) data files compliant with PubMed's document type definition (DTD). This paper describes the various attempts that the journal Images in Paediatric Cardiology made in its efforts to convert the journal contents (including all of the extant backlog) to PMC-compliant XML for archiving and indexing in PubMed after the journal was accepted for inclusion by the database.

Gaps in affiliation indexing in Scopus and PubMed.

Science.gov (United States)

Schmidt, Cynthia M; Cox, Roxanne; Fial, Alissa V; Hartman, Teresa L; Magee, Martha L

2016-04-01

The authors sought to determine whether unexpected gaps existed in Scopus's author affiliation indexing of publications written by the University of Nebraska Medical Center or Nebraska Medicine (UNMC/NM) authors during 2014. First, we compared Scopus affiliation identifier search results to PubMed affiliation keyword search results. Then, we searched Scopus using affiliation keywords (UNMC, etc.) and compared the results to PubMed affiliation keyword and Scopus affiliation identifier searches. We found that Scopus's records for approximately 7% of UNMC/NM authors' publications lacked appropriate UNMC/NM author affiliation identifiers, and many journals' publishers were supplying incomplete author affiliation information to PubMed. Institutions relying on Scopus to track their impact should determine whether Scopus's affiliation identifiers will, in fact, identify all articles published by their authors and investigators.

Med politiet i ’virkeligheden’: Reality-tv og kriminalitet

Directory of Open Access Journals (Sweden)

Ib Bondebjerg

2002-09-01

Full Text Available Kriminalstoffet på tv bliver ofte anklaget for at spekulere i vore lavere instinkter, og med reality kommer vi tættere end nogensinde på sam- fundets bund og det utrættelige politi, som har til opgave at opretholde lov og orden. Artiklen gennemgår en lang række af de senere års kri- minalprogrammer og diskuterer dokumentarismens former med en særlig belysning af æstetik, retorik og synsvinkel i undergenrerne »reality magasin« og »reality soap«. Lars Engels’ serie »Historier fra en politistation« tages op til særlig debat, fordi Engels – vanen tro – arbejder med en mindre iscenesættelse og ukommenteret virkelig- hedsgengivelse, end vi finder det i andre »reality soaps«.

Do Deregulated Cas Proteins Induce Genomic Instability In Early Stage Ovarian Cancer?

Science.gov (United States)

2007-12-01

Tensional homeostasis and the malignant phenotype. Cancer Cell 2005;8:241–54. [PubMed: 16169468] 40. Zhang Z, Hernandez- Lagunas L, Horne WC, Baron R...disassembly. Nat Cell Biol 2004;6:154–61. [PubMed: 14743221] 58. Huang J, Hamasaki H, Nakamoto T, Honda H, Hirai H, Saito M, Takato T, Sakai R...Cell Struct Funct 2001;26:619–26. [PubMed: 11942617] 87. Yi J, Kloeker S, Jensen CC, Bockholt S, Honda H, Hirai H, Beckerle MC. Members of the zyxin

Planning and scheduling algorithms for the COSMO-SkyMed constellation

NARCIS (Netherlands)

Bianchessi, Nicola; Righini, Giovanni

2008-01-01

The COSMO-SkyMed satellite constellation for the observation of the Earth is made of four satellites equipped with radar instruments and is intended for dual use, i.e. for security as well as for environmental monitoring purpose. The planning and scheduling problem for the COSMO-SkyMed constellation

Vejbygning i områder med permafrost

DEFF Research Database (Denmark)

Jørgensen, Anders Stuhr

2009-01-01

Siden begyndelsen af 1990’erne er der registreret en markant stigning i den årlige middeltemperatur i Nunavik, Québec Canada. Dette har ført til en reduktion i udbredelsen af permafrost, hvilket truer stabiliteten af lufthavne og veje i området. I sommeren 2007 blev en teststrækning opført i...... Tasiujaq Lufthavn for at studere effekten af tre forskellige metoder, som skal være med til at reducere optøningen af permafrost under landingsbanen. De tre metoder, som er blevet undersøgt, er konvektionskøling (air convection embankment), varmeudtrækning (heat drain) samt et forsøg med ændring af...

Grønnere skibsfart med modstandsdygtige motorer

DEFF Research Database (Denmark)

Lassen, Lisbeth

2015-01-01

Udledningen af forurening fra skibsmotorer skal sænkes kraftigt i de kommende år, og derfor står den maritime industri overfor helt nye krav til blandt andet hvilke brændstoffer, man kan bruge. På grund af de nye regler, der begrænser skibenes energiforbrug, er man også begyndt at sejle med nedsa...... foregår i samarbejde med DTU Kemiteknik og MAN Diesel & Turbo....... hastighed. Både de nye brændstoftyper og den nedsatte hastighed giver problemer for skibsmotorerne, problemer som projektet SULCOR, Sulfuric Acid corrosion in Large Marine Diesel Engines, netop har modtaget 16 millioner kr. fra Innovationsfonden til at begynde at løse. Projektet ledes af DTU Mekanik og...

Projekt Frit Sind hjælper mennesker med social angst

DEFF Research Database (Denmark)

Moutamid, Mina El

2017-01-01

Social angst er en almindelig, men overset lidelse, som ofte er forbundet med isolation. Mange fortæller ikke om den angst, de oplever, til andre og kommer til at leve et liv med begrænsninger, som de kunne være foruden, hvis de fik hjælp. Angsten betyder også, at det kan være svært at komme...... hjemmefra og opsøge hjælp hos SIND eller andre rådgivninger. Frit Sind er et nyt tilbud i København til disse mennesker og har fokus på de specifikke behov, mennesker med social angst har....

Procalcitonin til tidlig diagnostik af bakteriaemi hos børn med cancer

DEFF Research Database (Denmark)

Chawes, Bo Lund; Rechnitzer, Catherine; Schmiegelow, Kjeld

2007-01-01

INTRODUCTION: Fever and infections are common complications in children with cancer during chemotherapy. The purpose of this study was to investigate the usefulness of procalcitonin (PCT) in the identification of children with bacteraemia at time of admission with febrile episodes. Furthermore, w...

Et eller andet med sprog

DEFF Research Database (Denmark)

Adamsen, Billy; Nielsen, Charlotte Marie Bisgaard; Dam Christensen, Mie

2012-01-01

bedre sted, intet mindre. - Jeg frygter at de kommer til at kede sig på et reklamebureau med fx at lave kampagner og drikke champagne. Så jeg prøver at tale dem fra det. De skal finde ud af, hvem de er og hvad de gerne vil bruge deres liv på. Rådgiver for statsministeren Billy Adamsen har en phd i...

A synergetic hybridization of adsorption cycle with the multi-effect distillation (MED)

KAUST Repository

Thu, K.

2014-01-01

Multi-effect distillation (MED) systems are proven and energy efficient thermally-driven desalination systems for handling harsh seawater feed in the Gulf region. The high cycle efficiency is markedly achieved by latent energy re-use with minimal stage temperature-difference across the condensing steam and the evaporating saline seawater in each stage. The efficacies of MED system are (i) its low stage-temperature-difference between top brine temperature (TBT) and final condensing temperature, (ii) its robustness to varying salinity and ability to handle harmful algae Blooming (HABs) and (iii) its compact foot-print per unit water output. The practical TBT of MED systems, hitherto, is around 65 C for controllable scaling and fouling with the ambient-limited final condenser temperature, usually from 30 to 45 C. The adsorption (ADC) cycles utilize low-temperature heat sources (typically below 90 C) to produce useful cooling power and potable water. Hybridizing MED with AD cycles, they synergistically improve the water production rates at the same energy input whilst the AD cycle is driven by the recovered waste heat. We present a practical AD + MED combination that can be retrofitted to existing MEDs: The cooling energy of AD cycle through the water vapor uptake by the adsorbent is recycled internally, providing lower temperature condensing environment in the effects whilst the final condensing temperature of MED is as low as 5-10 C, which is below ambient. The increase in the temperature difference between TBT and final condensing temperature accommodates additional MED stages. A detailed numerical model is presented to capture the transient behaviors of heat and mass interactions in the combined AD + MED cycles and the results are presented in terms of key variables. It is observed that the water production rates of the combined cycle increase to give a GOR of 8.8 from an initial value of 5.9. © 2013 Elsevier Ltd. All rights reserved.

MedBlock: Efficient and Secure Medical Data Sharing Via Blockchain.

Science.gov (United States)

Fan, Kai; Wang, Shangyang; Ren, Yanhui; Li, Hui; Yang, Yintang

2018-06-21

With the development of electronic information technology, electronic medical records (EMRs) have been a common way to store the patients' data in hospitals. They are stored in different hospitals' databases, even for the same patient. Therefore, it is difficult to construct a summarized EMR for one patient from multiple hospital databases due to the security and privacy concerns. Meanwhile, current EMRs systems lack a standard data management and sharing policy, making it difficult for pharmaceutical scientists to develop precise medicines based on data obtained under different policies. To solve the above problems, we proposed a blockchain-based information management system, MedBlock, to handle patients' information. In this scheme, the distributed ledger of MedBlock allows the efficient EMRs access and EMRs retrieval. The improved consensus mechanism achieves consensus of EMRs without large energy consumption and network congestion. In addition, MedBlock also exhibits high information security combining the customized access control protocols and symmetric cryptography. MedBlock can play an important role in the sensitive medical information sharing.

Histologic heterogeneity of triple negative breast cancer: A National Cancer Centre Database analysis.

Science.gov (United States)

Mills, Matthew N; Yang, George Q; Oliver, Daniel E; Liveringhouse, Casey L; Ahmed, Kamran A; Orman, Amber G; Laronga, Christine; Hoover, Susan J; Khakpour, Nazanin; Costa, Ricardo L B; Diaz, Roberto

2018-06-02

Triple negative breast cancer (TNBC) is an aggressive disease, but recent studies have identified heterogeneity in patient outcomes. However, the utility of histologic subtyping in TNBC has not yet been well-characterised. This study utilises data from the National Cancer Center Database (NCDB) to complete the largest series to date investigating the prognostic importance of histology within TNBC. A total of 729,920 patients (pts) with invasive ductal carcinoma (IDC), metaplastic breast carcinoma (MBC), medullary breast carcinoma (MedBC), adenoid cystic carcinoma (ACC), invasive lobular carcinoma (ILC) or apocrine breast carcinoma (ABC) treated between 2004 and 2012 were identified in the NCDB. Of these, 89,222 pts with TNBC that received surgery were analysed. Kaplan-Meier analysis, log-rank testing and multivariate Cox proportional hazards regression were utilised with overall survival (OS) as the primary outcome. MBC (74.1%), MedBC (60.6%), ACC (75.7%), ABC (50.1%) and ILC (1.8%) had significantly different proportions of triple negativity when compared to IDC (14.0%, p < 0.001). TNBC predicted an inferior OS in IDC (p < 0.001) and ILC (p < 0.001). Lumpectomy and radiation (RT) were more common in MedBC (51.7%) and ACC (51.5%) and less common in MBC (33.1%) and ILC (25.4%), when compared to IDC (42.5%, p < 0.001). TNBC patients with MBC (HR 1.39, p < 0.001), MedBC (HR 0.42, p < 0.001) and ACC (HR 0.32, p = 0.003) differed significantly in OS when compared to IDC. Our results indicate that histologic heterogeneity in TNBC significantly informs patient outcomes and thus, has the potential to aid in the development of optimum personalised treatments. Copyright © 2018 Elsevier Ltd. All rights reserved.

Vekst, metabolisme og ølbrygging med melkesyrebakterier og gjær

OpenAIRE

Kvam, Guro

2017-01-01

Ølbrygging er et håndverk forbundet med lange tradisjoner, med røtter tilbake til det 12. århundrets Europa. Før dagens mikrobiologiske teknikker ble oppfunnet var all øl spontangjæret med en kompleks sammensetning av ulike gjær- og bakteriestammer. I dag produseres fremdeles enkelte av disse ølsortene under navn som lambic, geuze eller Berliner weisse, og interessen for slike ølsorter har økt betraktelig de siste årene. Mange bryggerier benytter i dag kjente kulturer av gjær og melkesyrebakt...

Role for the MED21-MED7 Hinge in Assembly of the Mediator-RNA Polymerase II Holoenzyme*

Science.gov (United States)

Sato, Shigeo; Tomomori-Sato, Chieri; Tsai, Kuang-Lei; Yu, Xiaodi; Sardiu, Mihaela; Saraf, Anita; Washburn, Michael P.; Florens, Laurence; Asturias, Francisco J.; Conaway, Ronald C.

2016-01-01

Mediator plays an integral role in activation of RNA polymerase II (Pol II) transcription. A key step in activation is binding of Mediator to Pol II to form the Mediator-Pol II holoenzyme. Here, we exploit a combination of biochemistry and macromolecular EM to investigate holoenzyme assembly. We identify a subset of human Mediator head module subunits that bind Pol II independent of other subunits and thus probably contribute to a major Pol II binding site. In addition, we show that binding of human Mediator to Pol II depends on the integrity of a conserved “hinge” in the middle module MED21-MED7 heterodimer. Point mutations in the hinge region leave core Mediator intact but lead to increased disorder of the middle module and markedly reduced affinity for Pol II. These findings highlight the importance of Mediator conformation for holoenzyme assembly. PMID:27821593

Den fuldt åbne MOOC med afsæt i aktuelle deltagere

DEFF Research Database (Denmark)

Hansbøl, Mikala; Erkmann, Malene; Munksgaard, Marianne Eilsø

2015-01-01

I dette afsnit præsenterer vi nogle af erfaringerne fra arbejdet med fire versioner af Videnskabsteori MOOC’en. Erfaringerne tager afsæt i vores kvalitative undersøgelser af deltagerperspektiver (UCSJ undervisere og MOOC deltagere) på MOOC-understøttet undervisning i, og læring af, anvendt...... videnskabsteori. MOOC litteraturen havde indtil 2013 primært beskæftiget sig med universitetsuddannelse, og der var stort set ikke skrevet noget om MOOCs i en dansk sammenhæng. Kjærgaard et al. (2013) leverede et første dansk bidrag, der kobler MOOCs med professionshøjskolerne i Danmark. Arbejdet med...... Videnskabsteori MOOC’en har især taget afsæt i en interesse i at forstå samspillet mellem deltagerforudsætninger, interesser og behov, og læringsmulighederne med MOOC’en. På den baggrund udpeger vi nogle væsentlige designelementer, der kan medtænkes i fremtidige udviklinger af tilsvarende fuldt åbne MOOCs...

PubMed had a higher sensitivity than Ovid-MEDLINE in the search for systematic reviews.

Science.gov (United States)

Katchamart, Wanruchada; Faulkner, Amy; Feldman, Brian; Tomlinson, George; Bombardier, Claire

2011-07-01

To compare the performance of Ovid-MEDLINE vs. PubMed for identifying randomized controlled trials of methotrexate (MTX) in patients with rheumatoid arthritis (RA). We created search strategies for Ovid-MEDLINE and PubMed for a systematic review of MTX in RA. Their performance was evaluated using sensitivity, precision, and number needed to read (NNR). Comparing searches in Ovid-MEDLINE vs. PubMed, PubMed retrieved more citations overall than Ovid-MEDLINE; however, of the 20 citations that met eligibility criteria for the review, Ovid-MEDLINE retrieved 17 and PubMed 18. The sensitivity was 85% for Ovid-MEDLINE vs. 90% for PubMed, whereas the precision and NNR were comparable (precision: 0.881% for Ovid-MEDLINE vs. 0.884% for PubMed and NNR: 114 for Ovid-MEDLINE vs. 113 for PubMed). In systematic reviews of RA, PubMed has higher sensitivity than Ovid-MEDLINE with comparable precision and NNR. This study highlights the importance of well-designed database-specific search strategies. Copyright © 2010 Elsevier Inc. All rights reserved.

How Complementary and Alternative Medicine Practitioners Use PubMed

Science.gov (United States)

Quint-Rapoport, Mia

2007-01-01

Background PubMed is the largest bibliographic index in the life sciences. It is freely available online and is used by professionals and the public to learn more about medical research. While primarily intended to serve researchers, PubMed provides an array of tools and services that can help a wider readership in the location, comprehension, evaluation, and utilization of medical research. Objective This study sought to establish the potential contributions made by a range of PubMed tools and services to the use of the database by complementary and alternative medicine practitioners. Methods In this study, 10 chiropractors, 7 registered massage therapists, and a homeopath (N = 18), 11 with prior research training and 7 without, were taken through a 2-hour introductory session with PubMed. The 10 PubMed tools and services considered in this study can be divided into three functions: (1) information retrieval (Boolean Search, Limits, Related Articles, Author Links, MeSH), (2) information access (Publisher Link, LinkOut, Bookshelf ), and (3) information management (History, Send To, Email Alert). Participants were introduced to between six and 10 of these tools and services. The participants were asked to provide feedback on the value of each tool or service in terms of their information needs, which was ranked as positive, positive with emphasis, negative, or indifferent. Results The participants in this study expressed an interest in the three types of PubMed tools and services (information retrieval, access, and management), with less well-regarded tools including MeSH Database and Bookshelf. In terms of their comprehension of the research, the tools and services led the participants to reflect on their understanding as well as their critical reading and use of the research. There was universal support among the participants for greater access to complete articles, beyond the approximately 15% that are currently open access. The abstracts provided by PubMed were

Professionel praksis i botilbud for mennesker med udviklingshæmning

DEFF Research Database (Denmark)

Engen, Mie

I dag varetager man i Danmark hovedsageligt omsorgen for mennesker med udviklingshæmning, der har behov for hjælp og støtte på døgnbasis, i § 107/108 boformer oprettet efter Lov om Social Service og Almenboliglovens § 105. Formålet med den professionelle praksis i boformerne er at varetage disse ...

Med-Ro Hybrid desalination as option to supply fresh water in BABEL Islands Province

International Nuclear Information System (INIS)

Siti Alimah; Sudi Ariyanto; June Mellawati; Budiarto

2011-01-01

Med-Ro hybrid desalination systems are combining both thermal (Med) and membrane (Ro) desalination processes with power generation systems. This configuration has more economical and operational benefits in comparison with single desalination plant. Hybrid configurations are characterized by flexibility in operation, specific energy consumption (33.50 kWh/m 3 ) is lower than Med (36.54 kWh/m 3 ) and high plant availability. The objective of study is to analyze the Med-Ro hybrid desalination as an option to add supply fresh water in Babel Islands Province, in terms of technology and economy aspects. The result of study showed that adopting nuclear power plants as dual-purpose for power generation and producing fresh water is has economic competitiveness than fossil-fired generation plants. Med-Ro hybrid configuration, with feed Ro from heat rejection of Med system is suitable as fresh water supply add option because increase of Ro feed temperature will increase flux. Economic analysis of water cost are performed using the Deep-3.2. Water cost of hybrid Med-Ro desalination with energy of NPP (0.581 $/m ) is lower than that of Med water cost (0.752 $/m ) . Water cost of hybrid Med-Ro with energy of NPP (0.581 $/m ) is lower than that of water cost of energy with fossil-fired generation plants (0.720 $/m 3 ). (author)

Individual differences in aversion to ambiguity regarding medical tests and treatments: association with cancer screening cognitions.

Science.gov (United States)

Han, Paul K J; Williams, Andrew E; Haskins, Amy; Gutheil, Caitlin; Lucas, F Lee; Klein, William M P; Mazor, Kathleen M

2014-12-01

Aversion to "ambiguity"-uncertainty about the reliability, credibility, or adequacy of information-about medical tests and treatments is an important psychological response that varies among individuals, but little is known about its nature and extent. The purpose of this study was to examine how individual-level ambiguity aversion relates to important health cognitions related to different cancer screening tests. A survey of 1,074 adults, ages 40 to 70 years, was conducted in four integrated U.S. healthcare systems. The Ambiguity Aversion in Medicine (AA-Med) scale, a measure of individual differences in aversion to ambiguity (AA) about medical tests and treatments, was administered along with measures of several cancer screening-related cognitions: perceived benefits and harms of colonoscopy, mammography, and PSA screening, and ambivalence and future intentions regarding these tests. Multivariable analyses were conducted to assess the associations between AA-Med scores and cancer screening cognitions. Individual-level AA as assessed by the AA-Med scale was significantly associated (P ambiguity. Individual-level AA constitutes a measurable, wide-ranging cognitive bias against medical intervention, and more research is needed to elucidate its mechanisms and effects. ©2014 American Association for Cancer Research.

Digital kommunikation med den offentlige sektor

DEFF Research Database (Denmark)

Berger, Jesper; Andersen, Kim Normann

2013-01-01

Denne rapport sammenfatter hovedresultaterne af en undersøgelse gennemført i juni måned 2013 om besvarelse af e-mail og digital post i den statslige, regionale og kommunale sektor. Allerede med eDag3 1. nov. 2010 skulle alle myndigheder have oprettet en digital postkasse, som borgerne kunne skrive...... til. I denne undersøgelse sættes der fokus på myndighedernes besvarelse af den digitale post. Digital post blev bl.a. etableret som et alternativ til almindelig e-mail for at det offentlige kan kommunikere med borgere og virksomheder på en sikker måde, dvs. uden at uvedkommende kan få adgang til...... følsomme oplysninger. Fokus for undersøgelsen er hvordan håndterer myndighederne besvarelserne i den digitale postkasse: svarer de på digital post og e-mail, hvor hurtigt svarer de og er svarene brugbare? Undersøgelsen medtager myndighedernes besvarelse af digital post og e-mail, dels for at kunne...

Digital kommunikation med den offentlige sektor

DEFF Research Database (Denmark)

Berger, Jesper Bull; Andersen, Kim Normann

Denne rapport sammenfatter hovedresultaterne for styrelser og statslige organisationer af en undersøgelse gennemført i sommeren 2013 om besvarelse af e-mail og digital post i den statslige, regionale og kommunale sektor. Allerede med eDag3 1. nov. 2010 skulle alle myndigheder have oprettet en...... digital postkasse, som borgerne kunne skrive til. I denne undersøgelse sættes der fokus på myndighedernes besvarelse af den digitale post. Digital post blev bl.a. etableret som et alternativ til almindelig e-mail for at det offentlige kan kommunikere med borgere og virksomheder på en sikker måde, dvs....... uden at uvedkommende kan få adgang til følsomme oplysninger. Fokus for undersøgelsen er hvordan håndterer myndighederne besvarelserne i den digitale postkasse: svarer de på digital post og e-mail, hvor hurtigt svarer de og er svarene brugbare? Vi har også undersøgt besvarelse af e-mail, dels...

Tværsektorielt samarbejde ved behandling af patienter med type 2-diabetes

DEFF Research Database (Denmark)

Munch, Lene; Røder, Michael E; Hansen, Ida H

2018-01-01

Hovedbudskaber • Sundhedsstyrelsen lægger vægt på tværsektorielt samarbejde omkring patienten med type 2-diabetes, men denne tankegang er dog ikke implementeret i det danske sundhedsvæsen • På organisatorisk niveau kan en stratificerings- og forløbsmodel give anvisninger til opgave- og...... udnyttelse af sundhedsvæsenets ressourcer samtidig med, at behandling af høj kvalitet fastholdes og udvikles for patienter med type 2-diabetes...

MedRapid--medical community & business intelligence system.

Science.gov (United States)

Finkeissen, E; Fuchs, H; Jakob, T; Wetter, T

2002-01-01

currently, it takes at least 6 months for researchers to communicate their results. This delay is caused (a) by partial lacks of machine support for both representation as well as communication and (b) by media breaks during the communication process. To make an integrated communication between researchers and practitioners possible, a general structure for medical content representation has been set up. The procedure for data entry and quality management has been generalized and implemented in a web-based authoring system. The MedRapid-system supports the medical experts in entering their knowledge into a database. Here, the level of detail is still below that of current medical guidelines representation. However, the symmetric structure for an area-wide medical knowledge representation is highly retrievable and thus can quickly be communicated into daily routine for the improvement of the treatment quality. In addition, other sources like journal articles and medical guidelines can be references within the MedRapid-system and thus be communicated into daily routine. The fundamental system for the representation of medical reference knowledge (from reference works/books) itself is not sufficient for the friction-less communication amongst medical staff. Rather, the process of (a) representing medical knowledge, (b) refereeing the represented knowledge, (c) communicating the represented knowledge, and (d) retrieving the represented knowledge has to be unified. MedRapid will soon support the whole process on one server system.

Improving accuracy for identifying related PubMed queries by an integrated approach.

Science.gov (United States)

Lu, Zhiyong; Wilbur, W John

2009-10-01

PubMed is the most widely used tool for searching biomedical literature online. As with many other online search tools, a user often types a series of multiple related queries before retrieving satisfactory results to fulfill a single information need. Meanwhile, it is also a common phenomenon to see a user type queries on unrelated topics in a single session. In order to study PubMed users' search strategies, it is necessary to be able to automatically separate unrelated queries and group together related queries. Here, we report a novel approach combining both lexical and contextual analyses for segmenting PubMed query sessions and identifying related queries and compare its performance with the previous approach based solely on concept mapping. We experimented with our integrated approach on sample data consisting of 1539 pairs of consecutive user queries in 351 user sessions. The prediction results of 1396 pairs agreed with the gold-standard annotations, achieving an overall accuracy of 90.7%. This demonstrates that our approach is significantly better than the previously published method. By applying this approach to a one day query log of PubMed, we found that a significant proportion of information needs involved more than one PubMed query, and that most of the consecutive queries for the same information need are lexically related. Finally, the proposed PubMed distance is shown to be an accurate and meaningful measure for determining the contextual similarity between biological terms. The integrated approach can play a critical role in handling real-world PubMed query log data as is demonstrated in our experiments.

A functional portrait of Med7 and the mediator complex in Candida albicans.

Science.gov (United States)

Tebbji, Faiza; Chen, Yaolin; Richard Albert, Julien; Gunsalus, Kearney T W; Kumamoto, Carol A; Nantel, André; Sellam, Adnane; Whiteway, Malcolm

2014-11-01

Mediator is a multi-subunit protein complex that regulates gene expression in eukaryotes by integrating physiological and developmental signals and transmitting them to the general RNA polymerase II machinery. We examined, in the fungal pathogen Candida albicans, a set of conditional alleles of genes encoding Mediator subunits of the head, middle, and tail modules that were found to be essential in the related ascomycete Saccharomyces cerevisiae. Intriguingly, while the Med4, 8, 10, 11, 14, 17, 21 and 22 subunits were essential in both fungi, the structurally highly conserved Med7 subunit was apparently non-essential in C. albicans. While loss of CaMed7 did not lead to loss of viability under normal growth conditions, it dramatically influenced the pathogen's ability to grow in different carbon sources, to form hyphae and biofilms, and to colonize the gastrointestinal tracts of mice. We used epitope tagging and location profiling of the Med7 subunit to examine the distribution of the DNA sites bound by Mediator during growth in either the yeast or the hyphal form, two distinct morphologies characterized by different transcription profiles. We observed a core set of 200 genes bound by Med7 under both conditions; this core set is expanded moderately during yeast growth, but is expanded considerably during hyphal growth, supporting the idea that Mediator binding correlates with changes in transcriptional activity and that this binding is condition specific. Med7 bound not only in the promoter regions of active genes but also within coding regions and at the 3' ends of genes. By combining genome-wide location profiling, expression analyses and phenotyping, we have identified different Med7p-influenced regulons including genes related to glycolysis and the Filamentous Growth Regulator family. In the absence of Med7, the ribosomal regulon is de-repressed, suggesting Med7 is involved in central aspects of growth control.

Health informatics research in Australia: retrospective analysis using PubMed

Directory of Open Access Journals (Sweden)

Kumara Mendis

2007-01-01

Discussion Australian HI publications in PubMed increased consistently throughout the period 1970-2005, which is on a par with world trends in HI publications. In Australia, most HI publications are in general medical journals. Lack of consistency in author names and failure to include the country name and even the state are the main obstacles to PubMed bibliometric analysis.

Murværk opmuret med vådmørtler

DEFF Research Database (Denmark)

Hansen, Klavs Feilberg

Vådmørtler benyttes i størstedelen af det murede nybyggeri. Egenskaberne af murværk opmuret med vådmørtel er i dag kun mangelfuldt dokumenteret. Denne rapport beskriver en metode til bedre dokumentation af de styrkemæssige egenskaber ved murværk opmuret med vådmørtel. Første del af rapporten genn...

Kvalitative Interviews med D&I Censorer, Undervisere, Kandidater og Studerende

DEFF Research Database (Denmark)

Brodersen, Søsser; Lindegaard, Hanne

2010-01-01

Som en opfølgning på telefon surveys blev der i tredje fase af D&I evalueringen gennemført en række kvalitative interviews med udvalgte censorer, undervisere, kandidater og studerende. Formålet med de kvalitative interviews har været at undersøge om: - D&I studerende og kandidater gennem forløbet i...

Hvad stiller vi op med samfundsneurosen?

DEFF Research Database (Denmark)

Jensen, Niels Rosendal

2008-01-01

Pædagogisk og socialt arbejde er som aldrig før udsat for evaluering, accountability, akkreditering m.v.  Det fjerner opmærksomheden fra kerneopgaven, at de professionelles ydelser forbedres. Forhistorien opridses kort, og klummen afrundes med at pege på tre mulige veje ud af samfundsneurosen: et...

Solar-assisted MED treatment of Eskom power station waste water

Science.gov (United States)

Roos, Thomas H.; Rogers, David E. C.; Gericke, Gerhard

2017-06-01

The comparative benefits of multi-effect distillation (MED) used in conjunction with Nano Filtration (NF), Reverse Osmosis (RO) and Eutectic Freeze Crystallization (EFC) are determined for waste water minimization for inland coal fired power stations for Zero Liquid Effluent Discharge (ZLED). A sequence of technologies is proposed to achieve maximal water recovery and brine concentration: NF - physico-chemical treatment - MED - EFC. The possibility of extending the concentration of RO reject arising from minewater treatment at the Lethabo power station with MED alone is evaluated with mineral formation modelling using the thermochemical modelling software Phreeq-C. It is shown that pretreatment is essential to extend the amount of water that can be recovered, and this can be beneficially supported by NF.

Enabling multi-level relevance feedback on PubMed by integrating rank learning into DBMS.

Science.gov (United States)

Yu, Hwanjo; Kim, Taehoon; Oh, Jinoh; Ko, Ilhwan; Kim, Sungchul; Han, Wook-Shin

2010-04-16

Finding relevant articles from PubMed is challenging because it is hard to express the user's specific intention in the given query interface, and a keyword query typically retrieves a large number of results. Researchers have applied machine learning techniques to find relevant articles by ranking the articles according to the learned relevance function. However, the process of learning and ranking is usually done offline without integrated with the keyword queries, and the users have to provide a large amount of training documents to get a reasonable learning accuracy. This paper proposes a novel multi-level relevance feedback system for PubMed, called RefMed, which supports both ad-hoc keyword queries and a multi-level relevance feedback in real time on PubMed. RefMed supports a multi-level relevance feedback by using the RankSVM as the learning method, and thus it achieves higher accuracy with less feedback. RefMed "tightly" integrates the RankSVM into RDBMS to support both keyword queries and the multi-level relevance feedback in real time; the tight coupling of the RankSVM and DBMS substantially improves the processing time. An efficient parameter selection method for the RankSVM is also proposed, which tunes the RankSVM parameter without performing validation. Thereby, RefMed achieves a high learning accuracy in real time without performing a validation process. RefMed is accessible at http://dm.postech.ac.kr/refmed. RefMed is the first multi-level relevance feedback system for PubMed, which achieves a high accuracy with less feedback. It effectively learns an accurate relevance function from the user's feedback and efficiently processes the function to return relevant articles in real time.

PubMedPortable: A Framework for Supporting the Development of Text Mining Applications.

Science.gov (United States)

Döring, Kersten; Grüning, Björn A; Telukunta, Kiran K; Thomas, Philippe; Günther, Stefan

2016-01-01

Information extraction from biomedical literature is continuously growing in scope and importance. Many tools exist that perform named entity recognition, e.g. of proteins, chemical compounds, and diseases. Furthermore, several approaches deal with the extraction of relations between identified entities. The BioCreative community supports these developments with yearly open challenges, which led to a standardised XML text annotation format called BioC. PubMed provides access to the largest open biomedical literature repository, but there is no unified way of connecting its data to natural language processing tools. Therefore, an appropriate data environment is needed as a basis to combine different software solutions and to develop customised text mining applications. PubMedPortable builds a relational database and a full text index on PubMed citations. It can be applied either to the complete PubMed data set or an arbitrary subset of downloaded PubMed XML files. The software provides the infrastructure to combine stand-alone applications by exporting different data formats, e.g. BioC. The presented workflows show how to use PubMedPortable to retrieve, store, and analyse a disease-specific data set. The provided use cases are well documented in the PubMedPortable wiki. The open-source software library is small, easy to use, and scalable to the user's system requirements. It is freely available for Linux on the web at https://github.com/KerstenDoering/PubMedPortable and for other operating systems as a virtual container. The approach was tested extensively and applied successfully in several projects.

Evaluation of Role of Myofibroblasts in Oral Cancer: A Systematic Review.

Science.gov (United States)

Sekhon, Harjeet K; Sircar, Keya; Kaur, Gurbani; Marwah, Muneet

2016-01-01

To conduct a systematic review on the role of myofibroblasts in progression of oral cancer. The myofibroblast is essential for the integrity of the mammalian body by virtue of its role in wound healing, but it also plays a negative role due to their role in promoting tumor development. Systematic review. Bibliographic searches were conducted in several electronic databases using all publications in PubMed, PubMed central, EMBASE, CancerLit, Google scholar, and Cochrane CCTR between 1990 and June 2015. The search of all publications from various electronic databases revealed 1,371 citations. The total number of studies considered for systematic review was 43. The total number of patients included in the studies was 990. Myofibroblasts are a significant component in stroma of oral cancer cases, though not identified in all cases. This systematic review shows that clinical, pathological, and immunohistochemistry tests have correlated the presence of high myofibroblast count in oral cancer cell stroma. Myofibroblasts play a significant role in oral cancer invasion and progression. Various studies have demonstrated their association with oral cancer. This review tends to highlight their role in the pathogenesis of oral cancer over the decade. Sekhon HK, Sircar K, Kaur G, Marwah M. Evaluation of Role of Myofibroblasts in Oral Cancer: A Systematic Review. Int J Clin Pediatr Dent 2016;9(3):233-239.

Effect of Thyrotropin Suppression Therapy on Bone in Thyroid Cancer Patients

OpenAIRE

Papaleontiou, Maria; Hawley, Sarah T.; Haymart, Megan R.

2015-01-01

Background. The thyroid cancer incidence is rising. Despite current guidelines, controversy exists regarding the degree and duration of thyrotropin suppression therapy. Also, its potential skeletal effects remain a concern to physicians caring for thyroid cancer patients. We conducted a review of published data to evaluate existing studies focusing on the skeletal effects of thyrotropin suppression therapy in thyroid cancer patients. Materials and Methods. A systematic search of the PubMed, O...

AliBaba: PubMed as a graph.

Science.gov (United States)

Plake, Conrad; Schiemann, Torsten; Pankalla, Marcus; Hakenberg, Jörg; Leser, Ulf

2006-10-01

The biomedical literature contains a wealth of information on associations between many different types of objects, such as protein-protein interactions, gene-disease associations and subcellular locations of proteins. When searching such information using conventional search engines, e.g. PubMed, users see the data only one-abstract at a time and 'hidden' in natural language text. AliBaba is an interactive tool for graphical summarization of search results. It parses the set of abstracts that fit a PubMed query and presents extracted information on biomedical objects and their relationships as a graphical network. AliBaba extracts associations between cells, diseases, drugs, proteins, species and tissues. Several filter options allow for a more focused search. Thus, researchers can grasp complex networks described in various articles at a glance. http://alibaba.informatik.hu-berlin.de/

Validation of search filters for identifying pediatric studies in PubMed

NARCIS (Netherlands)

Leclercq, Edith; Leeflang, Mariska M. G.; van Dalen, Elvira C.; Kremer, Leontien C. M.

2013-01-01

To identify and validate PubMed search filters for retrieving studies including children and to develop a new pediatric search filter for PubMed. We developed 2 different datasets of studies to evaluate the performance of the identified pediatric search filters, expressed in terms of sensitivity,

Trafikulykker med ældre bilister - litteraturundersøgelse

DEFF Research Database (Denmark)

Siren, Anu Kristiina

Andelen af ældre mennesker er i disse år hastigt stigende i de industrialiserede lande, herunder i Danmark. Som følge heraf vokser antallet af ældre bilister, og nutidens ældre forbliver aktive og mobile langt op i årene. Da mobilitet er en vigtig del af dagligdagen, skal transportsystemet blandt...... antal ældre trafikanter vil medføre flere sikkerhedsmæssige problemer. Tværtimod ser det ud, som om sikkerheden generelt vil øges i takt med det voksende antal ældre trafikanter. Denne positive udvikling er dog ikke ensbetydende med, at der ikke fortsat skal fokuseres på ældrevenlige løsninger i...

Mars Science Laboratory (MSL) Entry, Descent, and Landing Instrumentation (MEDLI): Complete Flight Data Set

Science.gov (United States)

Cheatwood, F. McNeil; Bose, Deepak; Karlgaard, Christopher D.; Kuhl, Christopher A.; Santos, Jose A.; Wright, Michael J.

2014-01-01

The Mars Science Laboratory (MSL) entry vehicle (EV) successfully entered the Mars atmosphere and landed the Curiosity rover safely on the surface of the planet in Gale crater on August 6, 2012. MSL carried the MSL Entry, Descent, and Landing (EDL) Instrumentation (MEDLI). MEDLI delivered the first in-depth understanding of the Mars entry environments and the response of the entry vehicle to those environments. MEDLI was comprised of three major subsystems: the Mars Entry Atmospheric Data System (MEADS), the MEDLI Integrated Sensor Plugs (MISP), and the Sensor Support Electronics (SSE). Ultimately, the entire MEDLI sensor suite consisting of both MEADS and MISP provided measurements that were used for trajectory reconstruction and engineering validation of aerodynamic, atmospheric, and thermal protection system (TPS) models in addition to Earth-based systems testing procedures. This report contains in-depth hardware descriptions, performance evaluation, and data information of the three MEDLI subsystems.

Current management of locally recurrent rectal cancer

DEFF Research Database (Denmark)

Nielsen, Mette Bak; Laurberg, Søren; Holm, Thorbjörn

2011-01-01

ABSTRACT Objective: A review of the literature was undertaken to provide an overview of the surgical management of locally recurrent rectal cancer (LRRC) after the introduction of total mesorectal excision (TME). Method: A systematic literature search was undertaken using PubMed, Embase, Web...

Mediator MED23 regulates basal transcription in vivo via an interaction with P-TEFb.

Science.gov (United States)

Wang, Wei; Yao, Xiao; Huang, Yan; Hu, Xiangming; Liu, Runzhong; Hou, Dongming; Chen, Ruichuan; Wang, Gang

2013-01-01

The Mediator is a multi-subunit complex that transduces regulatory information from transcription regulators to the RNA polymerase II apparatus. Growing evidence suggests that Mediator plays roles in multiple stages of eukaryotic transcription, including elongation. However, the detailed mechanism by which Mediator regulates elongation remains elusive. In this study, we demonstrate that Mediator MED23 subunit controls a basal level of transcription by recruiting elongation factor P-TEFb, via an interaction with its CDK9 subunit. The mRNA level of Egr1, a MED23-controlled model gene, is reduced 4-5 fold in Med23 (-/-) ES cells under an unstimulated condition, but Med23-deficiency does not alter the occupancies of RNAP II, GTFs, Mediator complex, or activator ELK1 at the Egr1 promoter. Instead, Med23 depletion results in a significant decrease in P-TEFb and RNAP II (Ser2P) binding at the coding region, but no changes for several other elongation regulators, such as DSIF and NELF. ChIP-seq revealed that Med23-deficiency partially reduced the P-TEFb occupancy at a set of MED23-regulated gene promoters. Further, we demonstrate that MED23 interacts with CDK9 in vivo and in vitro. Collectively, these results provide the mechanistic insight into how Mediator promotes RNAP II into transcription elongation.

The performances of standard and ResMed masks during bag-valve-mask ventilation.

Science.gov (United States)

Lee, Hyoung Youn; Jeung, Kyung Woon; Lee, Byung Kook; Lee, Seung Joon; Jung, Yong Hun; Lee, Geo Sung; Min, Yong Il; Heo, Tag

2013-01-01

A tight mask seal is frequently difficult to obtain and maintain during single-rescuer bag-valve-mask (BVM) ventilation. The ResMed mask (Bella Vista, NSW, Australia) is a continuous-positive-airway-pressure mask (CM) designed for noninvasive ventilation. In this study, we compared the ventilation performances of a standard mask (SM) and a ResMed CM using a simulation manikin in an out-of-hospital single-rescuer BVM ventilation scenario. Thirty emergency medical technicians (EMTs) performed two 2-minute attempts to ventilate a simulation manikin using BVM ventilation, alternatively, with the SM or the ResMed CM in a randomized order. Ventilation parameters including tidal volume and peak airway pressure were measured using computer analysis software connected to the simulation manikin. Successful volume delivery was defined as delivery of 440-540 mL of tidal volume in accord with present cardiopulmonary resuscitation guidelines. BVM ventilation using the ResMed CM produced higher mean (± standard deviation) tidal volumes (452 ± 50 mL vs. 394 ± 113 mL, p = 0.014) and had a higher proportion of successful volume deliveries (65.3% vs. 26.7%, p < 0.001) than that using the SM. Peak airway pressure was higher in BVM ventilation using the ResMed CM (p = 0.035). Stomach insufflation did not occur during either method. Twenty-nine of the participants (96.7%) preferred BVM ventilation using the ResMed CM. BVM ventilations using ResMed CM resulted in a significantly higher proportion of successful volume deliveries meeting the currently recommended range of tidal volume. Clinical studies are needed to determine the value of the ResMed CM for BVM ventilation.

Indsats for forældre til børn med ADHD

DEFF Research Database (Denmark)

Neubert, Katja

2012-01-01

Et nyt review, udarbejdet af forskergruppen omkring Morris Zwi, undersøger om interventionsprogrammer til forældre til børn med ADHD er effektive, når det gælder reducering af børnenes ADHD-relaterede adfærd og associerede problemer som eksempelvis indlæringsproblemer. Reviewet peger på, at en...... indsats til forældre til børn med ADHD kan have en gavnlig effekt på børnenes adfærd. Interventionen kan også være med til at sænke stressniveauet hos forældre til disse børn, og forbedre forældrenes selvtillid....

CDAPubMed: a browser extension to retrieve EHR-based biomedical literature

Directory of Open Access Journals (Sweden)

Perez-Rey David

2012-04-01

Full Text Available Abstract Background Over the last few decades, the ever-increasing output of scientific publications has led to new challenges to keep up to date with the literature. In the biomedical area, this growth has introduced new requirements for professionals, e.g., physicians, who have to locate the exact papers that they need for their clinical and research work amongst a huge number of publications. Against this backdrop, novel information retrieval methods are even more necessary. While web search engines are widespread in many areas, facilitating access to all kinds of information, additional tools are required to automatically link information retrieved from these engines to specific biomedical applications. In the case of clinical environments, this also means considering aspects such as patient data security and confidentiality or structured contents, e.g., electronic health records (EHRs. In this scenario, we have developed a new tool to facilitate query building to retrieve scientific literature related to EHRs. Results We have developed CDAPubMed, an open-source web browser extension to integrate EHR features in biomedical literature retrieval approaches. Clinical users can use CDAPubMed to: (i load patient clinical documents, i.e., EHRs based on the Health Level 7-Clinical Document Architecture Standard (HL7-CDA, (ii identify relevant terms for scientific literature search in these documents, i.e., Medical Subject Headings (MeSH, automatically driven by the CDAPubMed configuration, which advanced users can optimize to adapt to each specific situation, and (iii generate and launch literature search queries to a major search engine, i.e., PubMed, to retrieve citations related to the EHR under examination. Conclusions CDAPubMed is a platform-independent tool designed to facilitate literature searching using keywords contained in specific EHRs. CDAPubMed is visually integrated, as an extension of a widespread web browser, within the standard

Large Cell Neuroendocrine Cancer (LCNEC of uterine cervix

Directory of Open Access Journals (Sweden)

Gehanath Baral

2009-01-01

Full Text Available A rare type of cervical cancer was encountered as a neuroendocrine cancer of cervix. Clinically, the patient presented with bleeding per vagina. She refused biopsy in her first visit and did not come for follow up. However, after few months she came and since there was a polypoid growth from cervix, she was advised to undergo hysterectomy. Histopathologically, it was diagnosed as large cell type of neuroendocrine cancer. Multimodality systemic treatment was offered as per literature. Ibrahim Med. Coll. J. 2009; 3(1: 36-38

Observing floods from space: Experience gained from COSMO-SkyMed observations

Science.gov (United States)

Pierdicca, N.; Pulvirenti, L.; Chini, M.; Guerriero, L.; Candela, L.

2013-03-01

The COSMO-SkyMed mission offers a unique opportunity to obtain all weather radar images characterized by short revisit time, thus being useful for flood evolution mapping. The COSMO-SkyMed system has been activated several times in the last few years in occasion of flood events all over the world in order to provide very high resolution X-band SAR images useful for flood detection purposes. This paper discusses the major outcomes of the experience gained, within the framework of the OPERA Pilot Project funded by the Italian Space Agency, from using COSMO-SkyMed data for the purpose of near real time generation of flood maps. A review of the mechanisms which determine the imprints of the inundation on the radar images and of the fundamental simulation tools able to predict these imprints and help image interpretation is provided. The approach developed to process the data and to generate the flood maps is also summarized. Then, the paper illustrates the experience gained with COSMO-SkyMed by describing and discussing a number of significant examples. These examples demonstrate the potential of the COSMO-SkyMed system and the suitability of the approach developed for generating the final products, but they also highlight some critical aspects that require further investigations to improve the reliability of the flood maps.

Børn med ADHD skaber øget konflikt om morgenen

DEFF Research Database (Denmark)

Lange, Anne-Mette

2017-01-01

Dækning af ny forskning fra videnskabelige præsentationer på den femte Internationale ADHD Congress i Vancouver, 2017. http://propatienter.dk/sygdomme/psyken/280-born-med-adhd-skaber-oget-konflikt-om-morgenen.html......Dækning af ny forskning fra videnskabelige præsentationer på den femte Internationale ADHD Congress i Vancouver, 2017. http://propatienter.dk/sygdomme/psyken/280-born-med-adhd-skaber-oget-konflikt-om-morgenen.html...

The medical dictionary for regulatory activities (MedDRA).

Science.gov (United States)

Brown, E G; Wood, L; Wood, S

1999-02-01

The International Conference on Harmonisation has agreed upon the structure and content of the Medical Dictionary for Regulatory Activities (MedDRA) version 2.0 which should become available in the early part of 1999. This medical terminology is intended for use in the pre- and postmarketing phases of the medicines regulatory process, covering diagnoses, symptoms and signs, adverse drug reactions and therapeutic indications, the names and qualitative results of investigations, surgical and medical procedures, and medical/social history. It can be used for recording adverse events and medical history in clinical trials, in the analysis and tabulations of data from these trials and in the expedited submission of safety data to government regulatory authorities, as well as in constructing standard product information and documentation for applications for marketing authorisation. After licensing of a medicine, it may be used in pharmacovigilance and is expected to be the preferred terminology for international electronic regulatory communication. MedDRA is a hierarchical terminology with 5 levels and is multiaxial: terms may exist in more than 1 vertical axis, providing specificity of terms for data entry and flexibility in data retrieval. Terms in MedDRA were derived from several sources including the WHO's adverse reaction terminology (WHO-ART), Coding Symbols for a Thesaurus of Adverse Reaction Terms (COSTART), International Classification of Diseases (ICD) 9 and ICD9-CM. It will be maintained, further developed and distributed by a Maintenance Support Services Organisation (MSSO). It is anticipated that using MedDRA will improve the quality of data captured on databases, support effective analysis by providing clinically relevant groupings of terms and facilitate electronic communication of data, although as a new tool, users will need to invest time in gaining expertise in its use.

Checkpoint inhibitors in breast cancer

DEFF Research Database (Denmark)

Polk, Anne; Svane, Inge-Marie; Andersson, Michael

2018-01-01

INTRODUCTION: An increasing number of compounds directed against immune checkpoints are currently under clinical development. In this review we summarize current research in breast cancer. MATERIAL AND METHODS: A computer-based literature search was carried out using PubMed and EMBASE; data...... reported at international meetings and clinicaltrials.gov were included as well. RESULTS: The obtained overall response rate of PD-1/PD-L1 monotherapy varied from 5 to 30% in heavily pretreated triple negative breast cancer (TNBC). The median duration of progression free survival and overall survival were...... and induce long standing anti-tumor immunity in a subgroup of breast cancer patients. However, the identification of predictive biomarkers is crucial for further development of this treatment modality....

Retrieving clinical evidence: a comparison of PubMed and Google Scholar for quick clinical searches.

Science.gov (United States)

Shariff, Salimah Z; Bejaimal, Shayna Ad; Sontrop, Jessica M; Iansavichus, Arthur V; Haynes, R Brian; Weir, Matthew A; Garg, Amit X

2013-08-15

Physicians frequently search PubMed for information to guide patient care. More recently, Google Scholar has gained popularity as another freely accessible bibliographic database. To compare the performance of searches in PubMed and Google Scholar. We surveyed nephrologists (kidney specialists) and provided each with a unique clinical question derived from 100 renal therapy systematic reviews. Each physician provided the search terms they would type into a bibliographic database to locate evidence to answer the clinical question. We executed each of these searches in PubMed and Google Scholar and compared results for the first 40 records retrieved (equivalent to 2 default search pages in PubMed). We evaluated the recall (proportion of relevant articles found) and precision (ratio of relevant to nonrelevant articles) of the searches performed in PubMed and Google Scholar. Primary studies included in the systematic reviews served as the reference standard for relevant articles. We further documented whether relevant articles were available as free full-texts. Compared with PubMed, the average search in Google Scholar retrieved twice as many relevant articles (PubMed: 11%; Google Scholar: 22%; PGoogle Scholar: 8%; P=.07). Google Scholar provided significantly greater access to free full-text publications (PubMed: 5%; Google Scholar: 14%; PGoogle Scholar returns twice as many relevant articles as PubMed and provides greater access to free full-text articles.

Systematic review: epidemiology of Oesophageal Cancer in ...

African Journals Online (AJOL)

Methods:A pub med literature search was conducted for articles ranging from 1950 to 2009 database involving the following key words: oesophageal carcinoma, incidence, prevalence and sub-Saharan Africa.Results:Conclusion: Oesophageal cancer is on the increase in the Sub-Saharan African Region with uneven ...

Multiple Epiphyseal Dysplasia (MED: A Rare Type of Skeletal Dysplasia

Directory of Open Access Journals (Sweden)

Mohammad Imnul Islam

2012-06-01

Full Text Available Multiple epiphyseal dysplasia (MED is a congenital disorder of skeletal development that primarily affects the ends of long bones, causing progressive joint and bone inflammation and short stature. Mutations in several genes are responsible for pathogenesis of this disease. We are reporting a case of MED who presented with the complaints of multiple swelling of the joints which was associated with pain during movement for last seven years. The patient had flexion deformity of all the affected joints along with restriction of movement. These were associated with kyphosis, pectus carnitum, knock-knee and short stature. Radiological findings were suggestive of MED. Counseling was done with the parents regarding the etiology, progression and outcome of the disease.DOI: http://dx.doi.org/10.3329/bsmmuj.v5i1.11025 BSMMU J 2012; 5(1:57-60 

Arbetet med arbetsgivarvarumärkets attraktivitet : En kvalitativ intervjustudie i tre företag om hur arbetet med "Employer branding" ser ut och implementeras i företag.

OpenAIRE

Drugge, Marie; Bernelind, Diana

2013-01-01

Arbetet med att stärka ett arbetsgivarvarumärkes attraktivitet, både internt och externt, det alltmer välbekanta begreppet “Employer branding”, är ett vanligt förekommande koncept i dagens organisationer. Syftet med studien är att försöka ta reda på vad fenomenet “Employer branding” är och hur organisationer kan bedriva arbetet med att göra sitt arbetsgivarvarumärket attraktiv på den svenska arbetsmarknaden. Tieto, COWI och Klarna AB är de företag som deltar i studien. Begreppen legitimitet o...

Sjuksköterskors upplevelse vid vård av patienter med substansbrukssyndrom

OpenAIRE

Hanna, Johansson; Frida, Zetterman

2016-01-01

Bakgrund Tidigare forskning visar att sjuksköterskor har förutfattade meningar om patienter med en stigmatiserande diagnos. Sjuksköterskor stigmatiserar och har negativa attityder som påverkar deras vård av dessa patienter. Individer med substansbrukssyndrom är en grupp som är särskilt utsatt för stigmatisering i samhället. Dessa individer påträffas inom samtliga specialiteter inom vården. Denna studie fokuserar därför på sjuksköterskors upplevelse av patienter med substansbrukssyndrom. Syfte...

[Use of PubMed to improve evidence-based medicine in routine urological practice].

Science.gov (United States)

Rink, M; Kluth, L A; Shariat, S F; Chun, F K; Fisch, M; Dahm, P

2013-03-01

Applying evidence-based medicine in daily clinical practice is the basis of patient-centered medicine and knowledge of accurate literature acquisition skills is necessary for informed clinical decision-making. PubMed is an easy accessible, free bibliographic database comprising over 21 million citations from the medical field, life-science journals and online books. The article summarizes the effective use of PubMed in routine urological clinical practice based on a common case scenario. This article explains the simple use of PubMed to obtain the best search results with the highest evidence. Accurate knowledge about the use of PubMed in routine clinical practice can improve evidence-based medicine and also patient treatment.

Enriching PubMed Related Article Search with Sentence Level Co-citations

Science.gov (United States)

Tran, Nam; Alves, Pedro; Ma, Shuangge

2009-01-01

PubMed related article links identify closely related articles and enhance our ability to navigate the biomedical literature. They are derived by calculating the word similarity between two articles, relating articles with overlapping word content. In this paper, we propose to enrich PubMed with a new type of related article link based on citations within a single sentence (i.e. sentence level co-citations or SLCs). Using different similarity metrics, we demonstrated that articles linked by SLCs are highly related. We also showed that only half of SLCs are found among PubMed related article links. Additionally, we discuss how the citing sentence of an SLC explains the connection between two articles. PMID:20351935

Forord til den danske udgave af bogen rådgivning og terapi med børn

DEFF Research Database (Denmark)

Kragh-Müller, Grethe

2007-01-01

En bog om rådgivning og terapi med børn med en integrativ indfaldsvinkel. Der tages udgangspunkt i forskellige teorier og metoder.......En bog om rådgivning og terapi med børn med en integrativ indfaldsvinkel. Der tages udgangspunkt i forskellige teorier og metoder....

Historien med stort H endte i '89

DEFF Research Database (Denmark)

Østergaard, Uffe

2015-01-01

Revolution. Uffe Østergaard, Jean Monnet professor i europæisk historie på Copenhagen Business School, tager os med op, og betragter debatten om årsagerne til, og betydningen af, Murens fald i fugleperspektiv. Hvorfor var der ingen, der havde forudset begivenhederne?...

Professor Nukem - et eksperiment med oplevelsesbaseret forskningsformidling

DEFF Research Database (Denmark)

Sandvik, Kjetil; Thorhauge, Anne Mette

2007-01-01

Professor Nukem er resultatet af et forskningsprojekt om oplevelsesbaseret forskningsformidling der har form som et computerspil med tilhørende website, hvor brugeren interaktivt kan engagere sig i forskning omkring sociale og kulturelle aspekter ved computerspil. Professor Nukem kan spilles på...

CARING (CAncer Risk and INsulin analoGues): the association of diabetes mellitus and cancer risk with focus on possible determinants - a systematic review and a meta-analysis.

Science.gov (United States)

Starup-Linde, Jakob; Karlstad, Oystein; Eriksen, Stine Aistrup; Vestergaard, Peter; Bronsveld, Heleen K; de Vries, Frank; Andersen, Morten; Auvinen, Anssi; Haukka, Jari; Hjellvik, Vidar; Bazelier, Marloes T; Boer, Anthonius de; Furu, Kari; De Bruin, Marie L

2013-11-01

Patients suffering from diabetes mellitus (DM) may experience an increased risk of cancer; however, it is not certain whether this effect is due to diabetes per se. To examine the association between DM and cancers by a systematic review and meta-analysis according to the PRISMA guidelines. The systematic literature search includes Medline at PubMed, Embase, Cinahl, Bibliotek.dk, Cochrane library, Web of Science and SveMed+ with the search terms: "Diabetes mellitus", "Neoplasms", and "Risk of cancer". The included studies compared the risk of cancer in diabetic patients versus non-diabetic patients. All types of observational study designs were included. Diabetes patients were at a substantially increased risk of liver (RR=2.1), and pancreas (RR=2.2) cancer. Modestly elevated significant risks were also found for ovary (RR=1.2), breast (RR=1.1), cervix (RR=1.3), endometrial (RR=1.4), several digestive tract (RR=1.1-1.5), kidney (RR=1.4), and bladder cancer (RR=1.1). The findings were similar for men and women, and unrelated to study design. Meta-regression analyses showed limited effect modification of body mass index, and possible effect modification of age, gender, with some influence of study characteristics (population source, cancer- and diabetes ascertainment). Publication bias seemed to be present. Only published data were used in the analyses. The systematic review and meta-analysis confirm the previous results of increased cancer risk in diabetes and extend this to additional cancer sites. Physicians in contact with patients with diabetes should be aware that diabetes patients are at an increased risk of cancer.

Brand management og den refleksive forbruger - med semiotik som hjælpedisciplin

DEFF Research Database (Denmark)

Hermansen, Judy

2009-01-01

  Kritisk eftertanke er et væsentligt træk ved den refleksive forbruger - ofte parret med en vis negativitet overfor et brand, en reklame eller forbrugerisme i al almindelighed. Den refleksive forbrugertype kommer til udtryk hos for eksempel en anti-branding guru som Naomi Klein og hendes...... bestseller bog "No Logo" eller i græsrodsbevægelsen Adbusters ( https://www.adbusters.org/ ), der efterhånden i mange år har udsendt et månedsmagasin med kritik af forbrugersamfundet og al dets reklame og branding. Disse anti-forbrugs og anti-branding bevægelser udspringer af, og er identifikationspunkter...... - den refleksive forbruger skal have noget, der kan "brande" ham som anderledes end alle mainstreamforbrugerne. Den refleksive forbruger er med andre ord en Feinschmecker og i lighed med - eller måske rettere i endnu højere grad end - alle andre forbrugere signalerer den refleksive forbruger sin...

Use of scientific social networking to improve the research strategies of PubMed readers.

Science.gov (United States)

Evdokimov, Pavel; Kudryavtsev, Alexey; Ilgisonis, Ekaterina; Ponomarenko, Elena; Lisitsa, Andrey

2016-02-18

Keeping up with journal articles on a daily basis is an important activity of scientists engaged in biomedical research. Usually, journal articles and papers in the field of biomedicine are accessed through the Medline/PubMed electronic library. In the process of navigating PubMed, researchers unknowingly generate user-specific reading profiles that can be shared within a social networking environment. This paper examines the structure of the social networking environment generated by PubMed users. A web browser plugin was developed to map [in Medical Subject Headings (MeSH) terms] the reading patterns of individual PubMed users. We developed a scientific social network based on the personal research profiles of readers of biomedical articles. A browser plugin is used to record the digital object identifier or PubMed ID of web pages. Recorded items are posted on the activity feed and automatically mapped to PubMed abstract. Within the activity feed a user can trace back previously browsed articles and insert comments. By calculating the frequency with which specific MeSH occur, the research interests of PubMed users can be visually represented with a tag cloud. Finally, research profiles can be searched for matches between network users. A social networking environment was created using MeSH terms to map articles accessed through the Medline/PubMed online library system. In-network social communication is supported by the recommendation of articles and by matching users with similar scientific interests. The system is available at http://bioknol.org/en/.

Mining PubMed for Biomarker-Disease Associations to Guide Discovery

OpenAIRE

Jessen, Walter; Landschulz, Katherine; Turi, Thomas; Reams, Rachel

2012-01-01

Biomedical knowledge is growing exponentially; however, meta-knowledge around the data is often lacking. PubMed is a database comprising more than 21 million citations for biomedical literature from MEDLINE and additional life science journals dating back to the 1950s. To explore the use and frequency of biomarkers across human disease, we mined PubMed for biomarker-disease associations. We then ranked the top 100 linked diseases by relevance and mapped them to medical subject headings (MeSH)...

Neuropilin 2: Novel Biomarker and Therapeutic Target for Aggressive Prostate Cancer

Science.gov (United States)

2016-11-01

Expression and significance of vascular endothelial growth factor receptor 2 in bladder cancer . J. Urol. 175, 1245–1252 (2006). 130. Sato, K. et al...Expression of vascular endothelial growth factor gene and its receptor (flt-1) gene in urinary bladder cancer . Tohoku J. Exp. Med. 185, 173–184 (1998). R...inhibition should improve the efficacy of these therapies significantly. 15. SUBJECT TERMS Prostate cancer , VEGF, Neuropilin, IGF-1 receptor , PTEN, stem

Selvforsyning med øko-mineraler og -vitaminer

DEFF Research Database (Denmark)

Sehested, Jakob; Jensen, Søren Krogh; Søegaard, Karen

2010-01-01

Forskere ved DJF har vist, at det er muligt at opnå et tilstrækkeligt indhold af vitaminer og mineraler i foderrationen til økologiske malkekøer ved at anvende hjemmedyrkede grovfodermidler med en høj andel af mineral- og vitaminrige, grønne fodermidler. Udgivelsesdato: oktober......Forskere ved DJF har vist, at det er muligt at opnå et tilstrækkeligt indhold af vitaminer og mineraler i foderrationen til økologiske malkekøer ved at anvende hjemmedyrkede grovfodermidler med en høj andel af mineral- og vitaminrige, grønne fodermidler. Udgivelsesdato: oktober...

PubMed search strings for the study of agricultural workers' diseases.

Science.gov (United States)

Mattioli, Stefano; Gori, Davide; Di Gregori, Valentina; Ricotta, Lara; Baldasseroni, Alberto; Farioli, Andrea; Zanardi, Francesca; Galletti, Stefania; Colosio, Claudio; Curti, Stefania; Violante, Francesco S

2013-12-01

Several optimized search strategies have been developed in Medicine, and more recently in Occupational Medicine. The aim of this study was to identify efficient PubMed search strategies to retrieve articles regarding putative occupational determinants of agricultural workers' diseases. We selected the Medical Subjects Heading (MeSH) term agricultural workers' diseases and six MeSH terms describing farm work (agriculture, agrochemicals NOT pesticides, animal husbandry, pesticides, rural health, rural population) alongside 61 other promising terms. We estimated proportions of articles containing potentially pertinent information regarding occupational etiology to formulate two search strategies (one "more specific," one "more sensitive"). We applied these strategies to retrieve information on the possible occupational etiology among agricultural workers of kidney cancer, knee osteoarthritis, and multiple sclerosis. We evaluated the number of needed to read (NNR) abstracts to identify one potentially pertinent article in the context of these pathologies. The "more specific" search string was based on the combination of terms that yielded the highest proportion (40%) of potentially pertinent abstracts. The "more sensitive" string was based on use of broader search fields and additional coverage provided by other search terms under study. Using the "more specific" string, the NNR to find one potentially pertinent article were: 1.1 for kidney cancer; 1.4 for knee osteoarthritis; 1.2 for multiple sclerosis. Using the sensitive strategy, the NNR were 1.4, 3.6, and 6.3, respectively. The proposed strings could help health care professionals explore putative occupational etiology for agricultural workers' diseases (even if not generally thought to be work related). © 2013 Wiley Periodicals, Inc.

A search engine to access PubMed monolingual subsets: proof of concept and evaluation in French.

Science.gov (United States)

Griffon, Nicolas; Schuers, Matthieu; Soualmia, Lina Fatima; Grosjean, Julien; Kerdelhué, Gaétan; Kergourlay, Ivan; Dahamna, Badisse; Darmoni, Stéfan Jacques

2014-12-01

PubMed contains numerous articles in languages other than English. However, existing solutions to access these articles in the language in which they were written remain unconvincing. The aim of this study was to propose a practical search engine, called Multilingual PubMed, which will permit access to a PubMed subset in 1 language and to evaluate the precision and coverage for the French version (Multilingual PubMed-French). To create this tool, translations of MeSH were enriched (eg, adding synonyms and translations in French) and integrated into a terminology portal. PubMed subsets in several European languages were also added to our database using a dedicated parser. The response time for the generic semantic search engine was evaluated for simple queries. BabelMeSH, Multilingual PubMed-French, and 3 different PubMed strategies were compared by searching for literature in French. Precision and coverage were measured for 20 randomly selected queries. The results were evaluated as relevant to title and abstract, the evaluator being blind to search strategy. More than 650,000 PubMed citations in French were integrated into the Multilingual PubMed-French information system. The response times were all below the threshold defined for usability (2 seconds). Two search strategies (Multilingual PubMed-French and 1 PubMed strategy) showed high precision (0.93 and 0.97, respectively), but coverage was 4 times higher for Multilingual PubMed-French. It is now possible to freely access biomedical literature using a practical search tool in French. This tool will be of particular interest for health professionals and other end users who do not read or query sufficiently in English. The information system is theoretically well suited to expand the approach to other European languages, such as German, Spanish, Norwegian, and Portuguese.

Hinder för utomhusundervisning med fokus på årskurs 4-6

OpenAIRE

Petersson, Essi; Carstensen, Linnea

2018-01-01

I den här studien har vi tagit fram de hinder som begränsar möjligheterna för utomhusundervisning för elever i grundskolan, med fokus på årskurs 4-6 och middle school. Syftet med studien var att synliggöra vilka hinder som kan stå i vägen för utomhusundervisning samt visa på behov av vidare forskning i området. Forskningsfrågan som vi har försökt svara på är: Vad utgör hinder för utomhusundervisning med elever i grundskolan, med fokus på årskurs 4-6 och middle school? Studien bygger på den pr...

Fokus på fremme af livskvalitet og trivsel hos personer med demens gennem læringsmodel med musikterapi og Dementia Care Mapping som det fælles omdrejningspunkt

DEFF Research Database (Denmark)

Ottesen, Aase Marie

. Beskrivelse af den metode som er anvendt Metodisk er projektet tilrettelagt som et casestudie af et musikterapiforløb. I læringsmodellen tages afsæt i Tom Kitwoods teori og værdigrundlag om en personorienteret omsorg. Dementia Care Mapping (DCM) anvendes i læringsforløbet til at belyse de relationelle møder......, der opstår i musikterapien. Samtidig anvendes DCM som pædagogisk metode i feedbackprocessen med omsorgsgiverne, hvor der arbejdes på at give omsorgsgiverne redskaber til at bruge musik aktivt i deres interaktion med personer med demens i forskellige samværssituationer. Projektets teoretiske...

Sydkorea: Teknologiske tigerspring med globale udfordringer

DEFF Research Database (Denmark)

Brynskov, Martin

2010-01-01

Sydkorea har gennemgået en utrolig udvikling fra u-land til førende i-land i løbet af få årtier. Helt centralt står den teknologiske eksport af elektronik, biler og skibsbyggeri i verdenseliten. Men på trods af de mange succeser er der også udfordringer. Denne analyse viser – med aktuelle eksempl...

MedWatch Safety Alerts for Human Medical Products

Data.gov (United States)

U.S. Department of Health & Human Services — MedWatch alerts provide timely new safety information on human drugs, medical devices, vaccines and other biologics, dietary supplements, and cosmetics. The alerts...

Quantity and quality assessment of randomized controlled trials on orthodontic practice in PubMed.

Science.gov (United States)

Shimada, Tatsuo; Takayama, Hisako; Nakamura, Yoshiki

2010-07-01

To find current high-quality evidence for orthodontic practice within a reasonable time, we tested the performance of a PubMed search. PubMed was searched using publication type randomized controlled trial and medical subject heading term "orthodontics" for articles published between 2003 and 2007. The PubMed search results were compared with those from a hand search of four orthodontic journals to determine the sensitivity of PubMed search. We evaluated the precision of the PubMed search result and assessed the quality of individual randomized controlled trials using the Jadad scale. Sensitivity and precision were 97.46% and 58.12%, respectively. In PubMed, of the 277 articles retrieved, 161 (58.12%) were randomized controlled trials on orthodontic practice, and 115 of the 161 articles (71.42%) were published in four orthodontic journals: American Journal of Orthodontics and Dentofacial Orthopedics, The Angle Orthodontist, the European Journal of Orthodontics, and the Journal of Orthodontics. Assessment by the Jadad scale revealed 60 high-quality randomized controlled trials on orthodontic practice, of which 45 (75%) were published in these four journals. PubMed is a highly desirable search engine for evidence-based orthodontic practice. To stay current and get high-quality evidence, it is reasonable to look through four orthodontic journals: American Journal of Orthodontics and Dentofacial Orthopedics, The Angle Orthodontist, the European Journal of Orthodontics, and the Journal of Orthodontics.

PubMed Phrases, an open set of coherent phrases for searching biomedical literature

Science.gov (United States)

Kim, Sun; Yeganova, Lana; Comeau, Donald C.; Wilbur, W. John; Lu, Zhiyong

2018-01-01

In biomedicine, key concepts are often expressed by multiple words (e.g., ‘zinc finger protein’). Previous work has shown treating a sequence of words as a meaningful unit, where applicable, is not only important for human understanding but also beneficial for automatic information seeking. Here we present a collection of PubMed® Phrases that are beneficial for information retrieval and human comprehension. We define these phrases as coherent chunks that are logically connected. To collect the phrase set, we apply the hypergeometric test to detect segments of consecutive terms that are likely to appear together in PubMed. These text segments are then filtered using the BM25 ranking function to ensure that they are beneficial from an information retrieval perspective. Thus, we obtain a set of 705,915 PubMed Phrases. We evaluate the quality of the set by investigating PubMed user click data and manually annotating a sample of 500 randomly selected noun phrases. We also analyze and discuss the usage of these PubMed Phrases in literature search. PMID:29893755

Mediator MED23 Links Pigmentation and DNA Repair through the Transcription Factor MITF.

Science.gov (United States)

Xia, Min; Chen, Kun; Yao, Xiao; Xu, Yichi; Yao, Jiaying; Yan, Jun; Shao, Zhen; Wang, Gang

2017-08-22

DNA repair is related to many physiological and pathological processes, including pigmentation. Little is known about the role of the transcriptional cofactor Mediator complex in DNA repair and pigmentation. Here, we demonstrate that Mediator MED23 plays an important role in coupling UV-induced DNA repair to pigmentation. The loss of Med23 specifically impairs the pigmentation process in melanocyte-lineage cells and in zebrafish. Med23 deficiency leads to enhanced nucleotide excision repair (NER) and less DNA damage following UV radiation because of the enhanced expression and recruitment of NER factors to chromatin for genomic stability. Integrative analyses of melanoma cells reveal that MED23 controls the expression of a melanocyte master regulator, Mitf, by modulating its distal enhancer activity, leading to opposing effects on pigmentation and DNA repair. Collectively, the Mediator MED23/MITF axis connects DNA repair to pigmentation, thus providing molecular insights into the DNA damage response and skin-related diseases. Copyright © 2017 The Author(s). Published by Elsevier Inc. All rights reserved.

Obamas opgør med Bush låser ham i dronekrig

DEFF Research Database (Denmark)

Ulrich, Philip Christian

2013-01-01

En helt central del af Obamas valgkamp i 2008 var et opgør med dele af Bush administrationens krig mod terror. Obama er dog blevet fanget i en kontroversiel dronepolitik på grund af hans manglende succes med de indenrigspolitiske aspekter af opgøret...

Cluster symptoms in cancer patients: A systematic Review

OpenAIRE

Anastasios Tzenalis; Ioanna Vekili

2013-01-01

Clinical studies have shown that patients with cancer experience multiple and simultaneously occurring symptoms, both during the illness and the therapeutic interventions. Aim: The aim of the present systematic review study was to investigate the symptom complex (cluster symptoms) occurring in patients suffering from cancer and their effect on the outcome of the disease. Methods: Data collection was based on electronic databases «MEDLINE / PubMed», «CINAHL», «PsycINFO», «Science Direct», «Spr...

Targeting Histone Abnormality in Triple-Negative Breast Cancer

Science.gov (United States)

2015-08-01

therapy in receptor positive breast cancer: NCIC CTG MA.17. J Natl Cancer Inst. 97:1262- 71, 2005. PMID 16145047 142. Davidson NE, O’Neill AM, Vukov AM...1000507 3. Michejda CJ, Davidson NE, and Keefer LK. Photochemical perturbation of Z=E equilibria in nitrosamines. J . Chemistry Soc. Chem. Comm. 633...634, 1976 4. Hochberg MC, Davidson NE, and Kim WS. Lupus nephritis. Johns Hopkins Med. J . 150:101-106, 1982. PMID 7062572 5. Davidson NE, Bronzert DA

Research and development of the system for group examination of lung cancer by helical CT

International Nuclear Information System (INIS)

2003-03-01

For the ultimate purpose of heavy particle therapy of lung cancer at an early stage, the system in the title with low dose radiation has been investigated by cooperation of NIRS (as a leading part) and medical/industrial facilities all over the country. The project started essentially in 1984 and has been continuing at 2003. This book described Results hitherto and Materials for application to medical care at disaster (Hanshin-Awaji Earthquake Disaster in 1995) together with reference materials. Results contain all fields of nuclear medicine and of imaging involved in examination/diagnosis of lung cancer, achieved by NIRS, by Health management center and Faculty of Medicine, Chiba University and Japan Anti-Tuberculosis Association in Chiba, by the 3rd Department of Internal Medicine, Fac. Med., Chiba Univ., by Osaka Medical Center for Cancer and Cardiovascular Diseases, by Nippon Med. School, Arakawa-ku cancer protection center and Tokyo Metropolitan Univ. of Health Sciences, by Hitachi health management center, by Fukui Med. College, by Hitachi Medical Corp., by NTT research laboratories, and by Toyohashi Univ. of Technology. The Materials involve Process and summary of conducting the medical care activities, Improvement of the examination automobile, Supplementary equipments and measures for legal problems, System for the medical care activities, Record of the examination automobile activities, Problems in future, and Completion of the medical activities. Reference materials are related with the Materials above. (N.I.)

Tracking Australian health and medical research expenditure with a PubMed bibliometric method.

Science.gov (United States)

Mendis, Kumara; Bailey, Jannine; McLean, Rick

2015-06-01

To assess Australian health and medical research (HMR) investment returns by measuring the trends in HMR expenditure and PubMed publications by Australian authors. Bibliometric analysis collating Australian HMR expenditure reported by the Australian Institute of Health and Welfare and Australian HMR publications indexed in PubMed. Similar methods were applied to data from the United Kingdom and New Zealand. From financial year 2000/01 through 2011/12, HMR investment increased by 232% from $1.49 to $4.94 billion (current prices adjusted for inflation), while PubMed publications increased by 123% from 10,696 to 23,818. The average HMR investment required for a single PubMed publication rose by 49% from $139,304 in 2000/01 to $207,364 in 2011/12. Quality analyses showed an increase in systematic reviews, cohort studies and clinical trials, and a decrease in publications in PubMed's core clinical journal collection. Comparisons with New Zealand and the United Kingdom showed that Australia has had the greatest overall percentage increase in gross publication numbers and publications per capita. Our analyses confirm that increased HMR expenditure is associated with an increase in HMR publications in PubMed. Tracking HMR investment outcomes using this method could be useful for future policy and funding decisions at a federal and specific institution level. © 2015 Public Health Association of Australia.

Classification of neuropathic pain in cancer patients: A Delphi expert survey report and EAPC/IASP proposal of an algorithm for diagnostic criteria.

Science.gov (United States)

Brunelli, Cinzia; Bennett, Michael I; Kaasa, Stein; Fainsinger, Robin; Sjøgren, Per; Mercadante, Sebastiano; Løhre, Erik T; Caraceni, Augusto

2014-12-01

Neuropathic pain (NP) in cancer patients lacks standards for diagnosis. This study is aimed at reaching consensus on the application of the International Association for the Study of Pain (IASP) special interest group for neuropathic pain (NeuPSIG) criteria to the diagnosis of NP in cancer patients and on the relevance of patient-reported outcome (PRO) descriptors for the screening of NP in this population. An international group of 42 experts was invited to participate in a consensus process through a modified 2-round Internet-based Delphi survey. Relevant topics investigated were: peculiarities of NP in patients with cancer, IASP NeuPSIG diagnostic criteria adaptation and assessment, and standardized PRO assessment for NP screening. Median consensus scores (MED) and interquartile ranges (IQR) were calculated to measure expert consensus after both rounds. Twenty-nine experts answered, and good agreement was found on the statement "the pathophysiology of NP due to cancer can be different from non-cancer NP" (MED=9, IQR=2). Satisfactory consensus was reached for the first 3 NeuPSIG criteria (pain distribution, history, and sensory findings; MEDs⩾8, IQRs⩽3), but not for the fourth one (diagnostic test/imaging; MED=6, IQR=3). Agreement was also reached on clinical examination by soft brush or pin stimulation (MEDs⩾7 and IQRs⩽3) and on the use of PRO descriptors for NP screening (MED=8, IQR=3). Based on the study results, a clinical algorithm for NP diagnostic criteria in cancer patients with pain was proposed. Clinical research on PRO in the screening phase and on the application of the algorithm will be needed to examine their effectiveness in classifying NP in cancer patients. Copyright © 2014 International Association for the Study of Pain. Published by Elsevier B.V. All rights reserved.

An automatic method to generate domain-specific investigator networks using PubMed abstracts

Directory of Open Access Journals (Sweden)

Gwinn Marta

2007-06-01

Full Text Available Abstract Background Collaboration among investigators has become critical to scientific research. This includes ad hoc collaboration established through personal contacts as well as formal consortia established by funding agencies. Continued growth in online resources for scientific research and communication has promoted the development of highly networked research communities. Extending these networks globally requires identifying additional investigators in a given domain, profiling their research interests, and collecting current contact information. We present a novel strategy for building investigator networks dynamically and producing detailed investigator profiles using data available in PubMed abstracts. Results We developed a novel strategy to obtain detailed investigator information by automatically parsing the affiliation string in PubMed records. We illustrated the results by using a published literature database in human genome epidemiology (HuGE Pub Lit as a test case. Our parsing strategy extracted country information from 92.1% of the affiliation strings in a random sample of PubMed records and in 97.0% of HuGE records, with accuracies of 94.0% and 91.0%, respectively. Institution information was parsed from 91.3% of the general PubMed records (accuracy 86.8% and from 94.2% of HuGE PubMed records (accuracy 87.0. We demonstrated the application of our approach to dynamic creation of investigator networks by creating a prototype information system containing a large database of PubMed abstracts relevant to human genome epidemiology (HuGE Pub Lit, indexed using PubMed medical subject headings converted to Unified Medical Language System concepts. Our method was able to identify 70–90% of the investigators/collaborators in three different human genetics fields; it also successfully identified 9 of 10 genetics investigators within the PREBIC network, an existing preterm birth research network. Conclusion We successfully created a

An automatic method to generate domain-specific investigator networks using PubMed abstracts

Science.gov (United States)

Yu, Wei; Yesupriya, Ajay; Wulf, Anja; Qu, Junfeng; Gwinn, Marta; Khoury, Muin J

2007-01-01

Background Collaboration among investigators has become critical to scientific research. This includes ad hoc collaboration established through personal contacts as well as formal consortia established by funding agencies. Continued growth in online resources for scientific research and communication has promoted the development of highly networked research communities. Extending these networks globally requires identifying additional investigators in a given domain, profiling their research interests, and collecting current contact information. We present a novel strategy for building investigator networks dynamically and producing detailed investigator profiles using data available in PubMed abstracts. Results We developed a novel strategy to obtain detailed investigator information by automatically parsing the affiliation string in PubMed records. We illustrated the results by using a published literature database in human genome epidemiology (HuGE Pub Lit) as a test case. Our parsing strategy extracted country information from 92.1% of the affiliation strings in a random sample of PubMed records and in 97.0% of HuGE records, with accuracies of 94.0% and 91.0%, respectively. Institution information was parsed from 91.3% of the general PubMed records (accuracy 86.8%) and from 94.2% of HuGE PubMed records (accuracy 87.0). We demonstrated the application of our approach to dynamic creation of investigator networks by creating a prototype information system containing a large database of PubMed abstracts relevant to human genome epidemiology (HuGE Pub Lit), indexed using PubMed medical subject headings converted to Unified Medical Language System concepts. Our method was able to identify 70–90% of the investigators/collaborators in three different human genetics fields; it also successfully identified 9 of 10 genetics investigators within the PREBIC network, an existing preterm birth research network. Conclusion We successfully created a web-based prototype

Bør det være strafbart at have sex med dyr?

DEFF Research Database (Denmark)

Christiansen, Stine Billeschou; Greve, Vagn; Sandøe, Peter

2009-01-01

Artiklen opridser baggrunden for den standende diskussion om, hvorvidt der i Danmark bør være et generelt og absolut forbud mod menneskers seksuelle omgang med dyr. Indledningsvis gives et historisk overblik over udviklingen i den danske regulering af menneskers seksuelle omgang med dyr. Efterføl...

MedEx: a medication information extraction system for clinical narratives

Science.gov (United States)

Stenner, Shane P; Doan, Son; Johnson, Kevin B; Waitman, Lemuel R; Denny, Joshua C

2010-01-01

Medication information is one of the most important types of clinical data in electronic medical records. It is critical for healthcare safety and quality, as well as for clinical research that uses electronic medical record data. However, medication data are often recorded in clinical notes as free-text. As such, they are not accessible to other computerized applications that rely on coded data. We describe a new natural language processing system (MedEx), which extracts medication information from clinical notes. MedEx was initially developed using discharge summaries. An evaluation using a data set of 50 discharge summaries showed it performed well on identifying not only drug names (F-measure 93.2%), but also signature information, such as strength, route, and frequency, with F-measures of 94.5%, 93.9%, and 96.0% respectively. We then applied MedEx unchanged to outpatient clinic visit notes. It performed similarly with F-measures over 90% on a set of 25 clinic visit notes. PMID:20064797

The increasing incidence of anal cancer: can it be explained by trends in risk groups?

NARCIS (Netherlands)

van der Zee, R. P.; Richel, O.; de Vries, H. J. C.; Prins, J. M.

2013-01-01

Anal cancer incidence is gradually increasing. The cause of this increase is not exactly known. This systematic literature review aimed to investigate the trend in time of anal cancer incidence and to find an explanation for the supposed increase. The TRIP database and PubMed were searched for

Mitigation of Volcanic Risk: The COSMO-SkyMed Contribution

Science.gov (United States)

Sacco, Patrizia; Daraio, Maria Girolamo; Battagliere, Maria Libera; Coletta, Alessandro

2015-05-01

The Italian Space Agency (ASI) promotes Earth Observation (EO) applications related to themes such as the prediction, monitoring, management and mitigation of natural and anthropogenic hazards. The approach generally followed is the development and demonstration of prototype services, using currently available data from space missions, in particular the COSMO-SkyMed (Constellation of Small Satellites for Mediterranean basin observation) mission, which represents the largest Italian investment in Space System for EO and thanks to which Italy plays a key role worldwide. Projects funded by ASI provide the convergence of various national industry expertise, research and institutional reference users. In this context a significant example is represented by the ASI Pilot Projects, recently concluded, dealing with various thematic, such as volcanoes. In this paper a special focus will be addressed to the volcanic risk management and the contribution provided in this field by COSMO-SkyMed satellite constellation during the last years. A comprehensive overview of the various national and international projects using COSMO-SkyMed data for the volcanic risk mitigation will be given, highlighting the Italian contribution provided worldwide in this operational framework.

[Systematic literature search in PubMed : A short introduction].

Science.gov (United States)

Blümle, A; Lagrèze, W A; Motschall, E

2018-03-01

In order to identify current (and relevant) evidence for a specific clinical question within the unmanageable amount of information available, solid skills in performing a systematic literature search are essential. An efficient approach is to search a biomedical database containing relevant literature citations of study reports. The best known database is MEDLINE, which is searchable for free via the PubMed interface. In this article, we explain step by step how to perform a systematic literature search via PubMed by means of an example research question in the field of ophthalmology. First, we demonstrate how to translate the clinical problem into a well-framed and searchable research question, how to identify relevant search terms and how to conduct a text word search and a search with keywords in medical subject headings (MeSH) terms. We then show how to limit the number of search results if the search yields too many irrelevant hits and how to increase the number in the case of too few citations. Finally, we summarize all essential principles that guide a literature search via PubMed.

Mediator Med23 deficiency enhances neural differentiation of murine embryonic stem cells through modulating BMP signaling.

Science.gov (United States)

Zhu, Wanqu; Yao, Xiao; Liang, Yan; Liang, Dan; Song, Lu; Jing, Naihe; Li, Jinsong; Wang, Gang

2015-02-01

Unraveling the mechanisms underlying early neural differentiation of embryonic stem cells (ESCs) is crucial to developing cell-based therapies of neurodegenerative diseases. Neural fate acquisition is proposed to be controlled by a 'default' mechanism, for which the molecular regulation is not well understood. In this study, we investigated the functional roles of Mediator Med23 in pluripotency and lineage commitment of murine ESCs. Unexpectedly, we found that, despite the largely unchanged pluripotency and self-renewal of ESCs, Med23 depletion rendered the cells prone to neural differentiation in different differentiation assays. Knockdown of two other Mediator subunits, Med1 and Med15, did not alter the neural differentiation of ESCs. Med15 knockdown selectively inhibited endoderm differentiation, suggesting the specificity of cell fate control by distinctive Mediator subunits. Gene profiling revealed that Med23 depletion attenuated BMP signaling in ESCs. Mechanistically, MED23 modulated Bmp4 expression by controlling the activity of ETS1, which is involved in Bmp4 promoter-enhancer communication. Interestingly, med23 knockdown in zebrafish embryos also enhanced neural development at early embryogenesis, which could be reversed by co-injection of bmp4 mRNA. Taken together, our study reveals an intrinsic, restrictive role of MED23 in early neural development, thus providing new molecular insights for neural fate determination. © 2015. Published by The Company of Biologists Ltd.

Die EBM-Datenbank DynaMed für PocketPC und Palm

Directory of Open Access Journals (Sweden)

Dollfuß, Helmut

2007-09-01

Full Text Available DynaMed is a database for Evidence Based Medicine. Licencee can download a stand-alone version of this database onto their Personal Digital Assistant (PDA. Contents and aims of DynaMed will be introduced. Main features of the PDA-version will be presented and illustrated with screenshots.

ProMED-mail: 22 years of digital surveillance of emerging infectious diseases.

Science.gov (United States)

Carrion, Malwina; Madoff, Lawrence C

2017-05-01

ProMED-mail (ProMED) was launched in 1994 as an email service to identify unusual health events related to emerging and re-emerging infectious diseases and toxins affecting humans, animals and plants. It is used daily by public health leaders, government officials at all levels, physicians, veterinarians and other healthcare workers, researchers, private companies, journalists and the general public. Reports are produced and commentary provided by a global team of subject matter experts in a variety of fields including virology, parasitology, epidemiology, entomology, veterinary and plant disease specialists. ProMED operates 24 hours a day, 7 days a week and has over 83 000 subscribers, representing every country in the world. Additionally, ProMED disseminates information via its website and through social media channels such as Twitter and Facebook as well as through RSS feeds. Over the last 22 years, it has been the first to report on numerous major and minor disease outbreaks including SARS, MERS, Ebola and the early spread of Zika. ProMED is transparent, apolitical, open to all and free of charge, making it an important and longstanding contributor to global health surveillance. © The Author 2017. Published by Oxford University Press on behalf of Royal Society of Tropical Medicine and Hygiene. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

A New Method for Weak Fault Feature Extraction Based on Improved MED

Directory of Open Access Journals (Sweden)

Junlin Li

2018-01-01

Full Text Available Because of the characteristics of weak signal and strong noise, the low-speed vibration signal fault feature extraction has been a hot spot and difficult problem in the field of equipment fault diagnosis. Moreover, the traditional minimum entropy deconvolution (MED method has been proved to be used to detect such fault signals. The MED uses objective function method to design the filter coefficient, and the appropriate threshold value should be set in the calculation process to achieve the optimal iteration effect. It should be pointed out that the improper setting of the threshold will cause the target function to be recalculated, and the resulting error will eventually affect the distortion of the target function in the background of strong noise. This paper presents an improved MED based method of fault feature extraction from rolling bearing vibration signals that originate in high noise environments. The method uses the shuffled frog leaping algorithm (SFLA, finds the set of optimal filter coefficients, and eventually avoids the artificial error influence of selecting threshold parameter. Therefore, the fault bearing under the two rotating speeds of 60 rpm and 70 rpm is selected for verification with typical low-speed fault bearing as the research object; the results show that SFLA-MED extracts more obvious bearings and has a higher signal-to-noise ratio than the prior MED method.

Lærerens dilemma - mellem ideal og praksis: en virksomhedsteoretisk analyse af progressiv undervisning med it

DEFF Research Database (Denmark)

Lorentzen, Rasmus Fink

Denne ph.d.-afhandling bidrager til det fagdidaktiske forskningsfelt inden for læreruddannelsen med viden om dansklæreres didaktiske praksis med it-understøttet progressiv undervisning i udskolingen. Afhandlingen leverer et svar på spørgsmålet om, hvordan progressiv undervisning med it i dansk ka...

Automated Aerial Refueling Presentation to 2007 ARSAG Conference (Preprint)

Science.gov (United States)

2007-04-01

this technology allows manned or unmanned platforms to fly formation in IFR conditions. 3 3Approved for public release; distribution is unlimited...conducted in conjunction with the DARPA TTNT China Lake test It was determine that TTNT needed slight modifications which have been incorporated. Station

Assessment of quality of life in patients with laryngeal cancer: A review of articles.

Science.gov (United States)

Kolator, Mateusz; Kolator, Patrycja; Zatoński, Tomasz

2018-04-19

This article presents a review of the medical literature published between 1994 and 2014 with the use of the PubMed database concerning quality-of-life instruments for head and neck cancer patients used to assess general well-being of patients with laryngeal cancer. The PubMed database was searched for articles containing the keywords "quality of life", "laryngeal neoplasm" and "questionnaires". The resulting articles were reviewed and analyzed. After the identification of questionnaires, an additional search was performed. The articles and questionnaires were described and analyzed. In 43 articles, the authors used questionnaires specific to the head and neck regions in order to assess the quality of life in patients with laryngeal cancer. Four different questionnaires were identified. The European Organization for Research and Treatment of Cancer (EORTC) questionnaire is most commonly used to assess the quality of life in patients with laryngeal cancer. Questionnaires are generally used in order to select from a range of different treatment methods. There are a few head and neck cancer-related quality-of-life instruments which are widely used to assess the quality of life in patients with laryngeal cancer, but they are not dedicated to that region of the body. Today, there is much more attention paid to the quality of life; therefore, there is a real need to develop specific scales for different types of cancer.

Trends of cervical cancer in Greenland

DEFF Research Database (Denmark)

Sander, Bente B; Rebolj, Matejka; Lynge, Elsebeth

2014-01-01

BACKGROUND: Due to its extraordinarily fast economic and social transition, virtually closed borders before 1940 and, moreover, that 85% of the population has the distinctive genetics of the Inuit, Greenland is a very interesting country to study cervical cancer from a historical perspective....... Nevertheless, little has been reported about long-term cancer trends in Greenland. Our aim was to describe and interpret the incidence of cervical cancer from 1950 to 2009. MATERIAL AND METHODS: We systematically searched PubMed for articles reporting the incidence of cervical cancer in Greenland. We...... supplemented this with data for 1980-2009 obtained from the Chief Medical Officer of Greenland. RESULTS: Incidence of cervical cancer was around 10 per 100 000 women (age-standardised, world population, ASW) in the 1950s, 30 per 100 000 in the 1960s, and in the 1980s around 60 per 100 000. From 1985 onwards...

A novel mutation in MED12 causes FG syndrome (Opitz-Kaveggia syndrome)

NARCIS (Netherlands)

Rump, P.; Niessen, R. C.; Verbruggen, K. T.; Brouwer, O. F.; de Raad, M.; Hordijk, R.

Opitz-Kaveggia syndrome is a rare X-linked multiple congenital anomalies and intellectual disability disorder caused by the recurrent p.R961W mutation in the MED12 gene. Twenty-three affected males from 10 families with this mutation in the MED12 gene have been described so far. Here we report on a

Erfaringer med Journal Club på modul 12

DEFF Research Database (Denmark)

Koustrup, Pia; Røge Aagaard, Lene

2013-01-01

I Ortopædkirurgisk afdeling, Aarhus Universitets Hospital, har vi i samarbejde med undervisere fra VIA University College udviklet og implementeret studieaktiviteten Journal Club. Studieaktiviteten afvikles indenfor rammerne af den kliniske studiemetode ”Seminar” og den planlagte studieaktivitet ...

Sexual activity and the risk of prostate cancer: Review article

Directory of Open Access Journals (Sweden)

Ahmed Fouad Kotb

2015-09-01

Full Text Available Introduction: Sexual activity can affect prostate cancer pathogenesis in a variety of ways; including the proposed high androgen status, risk of sexually transmitted infections and the potential effect of retained carcinogens within the prostatic cells. Methods: PubMed review of all publications concerning sexual activity and the risk of prostate cancer was done by two researchers. Results: Few publications could be detected and data were classified as a prostate cancer risk in association with either heterosexual or homosexual activities. Conclusion: Frequent ejaculation seems to be protective from the development of prostate cancer. Multiple sexual partners may be protective from prostate cancer, excluding the risk of sexually transmitted infections. Homosexual men are at a greater risk for the diagnosis of prostate cancer.

EU-retlige og forvaltningsretlige aspekter ved kommunernes tilsyn med taxiførere

DEFF Research Database (Denmark)

Sørensen, Henning Fuglsang

2011-01-01

Afhandlingen gennemgår taxilovens krav til kommunernes tilsyn med førere af taxier, herunder særligt de eu-retlige og forvaltningsretlige problemer i dette tilsyn.......Afhandlingen gennemgår taxilovens krav til kommunernes tilsyn med førere af taxier, herunder særligt de eu-retlige og forvaltningsretlige problemer i dette tilsyn....

Early Start Denver Model - intervention for de helt små børn med autisme

DEFF Research Database (Denmark)

Brynskov, Cecilia

2015-01-01

Early Start Denver Model (ESDM) er en autismespecifik interventionsmetode, som er udviklet til helt små børn med autisme (0-4 år). Metoden fokuserer på at styrke den tidlige kontakt og barnets motivation, og den arbejder målrettet med de socio-kommunikative forløbere for sprog og med den tidlige...

Characterization and Targeting of the Aldehyde Dehydrogenase Subpopulation in Ovarian Cancer

Science.gov (United States)

2016-10-01

Grizzle W, Landen C, Partridge EE, Rice VM, Reddy ES, Rao VN. Epithelial ovarian cancer: An overview. World J Transl Med. 2014 Apr 12;3(1):1-8. PMID...malignant human colonic stem cells (SC) and tracks SC overpopulation during colon tumorigenesis. Cancer Res 2009;69:3382–9. 16. Carpentino JE, HynesMJ...the TGF-b coreceptor endoglin in cancer. Sci World J 2010;10:2367–84. 40. Henriksen R, Gobl A, Wilander E, Oberg K, Miyazono K, Funa K. Expression and

Notat om arbejdet med innovation i Randers Kommune

DEFF Research Database (Denmark)

Hansen, Morten Balle; Agger Nielsen, Jeppe

2012-01-01

for innovation i Randers Kommune, herunder hvordan politikerne inddrages i innovationsprocessen, 5) Hvor tæt skal økonomi og innovationsdagsorden knyttes? 6) Hvordan er innovationsdagsordenen relateret til en overordnet strategi for Randers Kommune? og 7) selve organiseringen af innovationsprocessen. Notatet...... hovedpunkter er; 1) udarbejdelse af de gode innovationsspørgsmål, 2) dobbeltudfordringen med på den ene side at sikre daglig drift og på den anden side at arbejde innovativt, 3) top-down versus bottom-up processer, dvs. hvor meget skal innovationsprocesserne designes og styres? 4) den særlige kontekst......Dette notat udgør en erfaringsopsamling fra innovationsdag i Randers Kommune, d. 13. november 2012. Notatet fremhæver hovedpointerne fra interne og eksterne oplægsholdere og udpeger en række fokuspunkter/problemstillinger for arbejdet med innovation i Randers Kommune. De syv identificerede...

Serous ovarian, fallopian tube and primary peritoneal cancers

DEFF Research Database (Denmark)

Sørensen, Rie D; Schnack, Tine H; Karlsen, Mona A

2015-01-01

OBJECTIVE: The aim of this systematic review is to analyze data on risk factors, epidemiology, clinicopathology and molecular biology from studies comparing primary peritoneal cancer, fallopian tube cancer and ovarian cancer of serous histology, in order to achieve a greater understanding...... of whether or not these disorders should be considered as separate entities. METHODS: A systematic literature search was conducted in PubMed and MEDLINE. Case-control studies comparing primary serous peritoneal or fallopian tube carcinomas with primary serous ovarian carcinomas or a control group were...... included. RESULTS: Twenty-eight studies were found eligible. Primary peritoneal cancer patients were older, had higher parity, were more often obese and had poorer survival compared to ovarian cancer patients. Differences in protein expression patterns of Her2/neu, estrogen and progestin receptors...

Occupational Therapy for Adults With Cancer: Why It Matters.

Science.gov (United States)

Pergolotti, Mackenzi; Williams, Grant R; Campbell, Claudine; Munoz, Lauro A; Muss, Hyman B

2016-03-01

Adults with cancer may be at risk for limitations in functional status and quality of life (QOL). Occupational therapy is a supportive service with the specific mission to help people functionally engage in life as safely and independently as possible with the primary goal of improving QOL. Unfortunately, for people with cancer, occupational therapy remains underused. The overall purpose of this review is to provide an understanding of what occupational therapy is and its relevance to patients with cancer, highlight the reasons to refer, and, last, provide general advice on how to access services. ©AlphaMed Press.

MED1 independent activation of endogenous target genes by PPARα

DEFF Research Database (Denmark)

Grøntved, Lars; Bugge, Anne K.; Roeder, Robert G.

The mediator complex serves as a transcriptional co-activator complex by acting as a bridge between promoter-bound transcription factors and the preinitiation complex. Genetic and biochemical studies indicate that nuclear receptors recruit the mediator complex through direct interaction with the ......The mediator complex serves as a transcriptional co-activator complex by acting as a bridge between promoter-bound transcription factors and the preinitiation complex. Genetic and biochemical studies indicate that nuclear receptors recruit the mediator complex through direct interaction...... derived from TRAP220 KO mice. Interestingly, rescue experiments in confluent TRAP220 KO MEFs with different versions of MED1 indicate that the LXXLL motif is not necessary for PPARgamma mediated gene activation (Ge et al, MCB published online ahead of print 2007). By analogy, we show here that MED1...... is dispensable for PPARalpha transcriptional activity in proliferating but is necessary in confluent AML-12 cells and TRAP220 KO MEFs. Collectively this indicates that the PPARs might have adopted an alternative mediator recruitment mechanism that is dispensable of direct interaction with MED1 on endogenous...

Disrupt dit Mindset og få succes med Big Data

DEFF Research Database (Denmark)

Rydén, Pernille; Ringberg, Torsten; Østergaard Jacobsen, Per

Organisationer fokuserer i stigende grad på, hvordan de kan bruge Big Data strategisk. De investerer milliarder af kroner i denne ny teknologi, men værdien og afkastet viser sig tit at være begrænset. Sådanne udfordringer kan meget vel skyldes ledernes mindset, der begrænser hvordan organisationen...... bruger Big Data-teknologi til at styrke interaktionen og samspillet med kunder og andre interessenter. Det første skridt på vejen mod at få succes med Big Data er derfor at identificere og udfordre sit ledelsesmæssige mindset. I denne bog identificerer og diskuterer vi fire dominerende ledelsesmæssige...... mindset, der hver især fører til fire unikke Big Data strategier. Når ledere inden for samme team har forskellige mindset, kan det føre til manglende mental og organisatorisk alignment og problemer med at håndtere disruption. Da mindsets ofte er ubevidste, har vi udviklet en onlinetest, der hjælper dig og...

Global surveillance of emerging diseases: the ProMED-mail perspective

Directory of Open Access Journals (Sweden)

John P. Woodall

2001-01-01

Full Text Available The Internet is changing the way global disease surveillance is conducted. Countries and international organizations are increasingly placing their outbreak reports on the Internet, which speeds up distribution and therefore prevention and control. The World Health Organization (WHO has recognized the value of nongovernmental organizations and the media in reporting outbreaks, which it then attempts to verify through its country offices. However, WHO and other official sources are constrained in their reporting by the need for bureaucratic clearance. ProMED-mail has no such constraints, and posts outbreak reports 7 days a week. It is moderated by infectious disease specialists who add relevant comments. Thus, ProMED-mail complements official sources and provides early warning of outbreaks. Its network is more than 20,000 people in over 150 countries, who place their computers and time at the network's disposal and report on outbreaks of which they have knowledge. Regions and countries could benefit from adopting the ProMED-mail approach to complement their own disease surveillance systems.

Psychosocial Assessment as a Standard of Care in Pediatric Cancer

NARCIS (Netherlands)

Kazak, Anne E.; Abrams, Annah N.; Banks, Jaime; Christofferson, Jennifer; DiDonato, Stephen; Grootenhuis, Martha A.; Kabour, Marianne; Madan-Swain, Avi; Patel, Sunita K.; Zadeh, Sima; Kupst, Mary Jo

2015-01-01

This paper presents the evidence for a standard of care for psychosocial assessment in pediatric cancer. An interdisciplinary group of investigators utilized EBSCO, PubMed, PsycINFO, Ovid, and Google Scholar search databases, focusing on five areas: youth/family psychosocial adjustment, family

47 CFR 95.628 - MedRadio transmitters.

Science.gov (United States)

2010-10-01

... bands, or at 403.65 MHz in the 402-405 MHz band. (3) MedRadio stations associated with medical body-worn... applicable to medical implant device operation in the 402-405 MHz band. (d) Authorized bandwidth. The... 401-406 MHz band must operate under the control of a monitoring system that incorporates a mechanism...

Silencing SlMED18, tomato Mediator subunit 18 gene, restricts internode elongation and leaf expansion.

Science.gov (United States)

Wang, Yunshu; Hu, Zongli; Zhang, Jianling; Yu, XiaoHui; Guo, Jun-E; Liang, Honglian; Liao, Changguang; Chen, Guoping

2018-02-19

Mediator complex, a conserved multi-protein, is necessary for controlling RNA polymerase II (Pol II) transcription in eukaryotes. Given little is known about them in tomato, a tomato Mediator subunit 18 gene was isolated and named SlMED18. To further explore the function of SlMED18, the transgenic tomato plants targeting SlMED18 by RNAi-mediated gene silencing were generated. The SlMED18-RNAi lines exhibited multiple developmental defects, including smaller size and slower growth rate of plant and significantly smaller compound leaves. The contents of endogenous bioactive GA 3 in SlMED18 silenced lines were slightly less than that in wild type. Furthermore, qRT-PCR analysis indicated that expression of gibberellins biosynthesis genes such as SlGACPS and SlGA20x2, auxin transport genes (PIN1, PIN4, LAX1 and LAX2) and several key regulators, KNOX1, KNOX2, PHAN and LANCEOLATE(LA), which involved in the leaf morphogenesis were significantly down-regulated in SlMED18-RNAi lines. These results illustrated that SlMED18 plays an essential role in regulating plant internode elongation and leaf expansion in tomato plants and it acts as a key positive regulator of gibberellins biosynthesis and signal transduction as well as auxin proper transport signalling. These findings are the basis for understanding the function of the individual Mediator subunits in tomato.

Sundhedsfremmende natur for mennesker med bevægelseshandicap

DEFF Research Database (Denmark)

Stigsdotter, Ulrika K.; Gramkow, Marie C.; Lygum, Victoria L.

Rapporten bygger på et forskningsprojekt, der er forankret i et partnerskab med Handicapidrættens Videnscenter, Danske Handicaporganisationer, Bevica Fonden og 15. Juni Fonden og ledes af forskergruppen Natur, Sundhed & Design på Københavns Universitet. Desuden deltager Statens Byggeforskningsins...

CARING (CAncer Risk and INsulin analoGues): The Association of Diabetes Mellitus and Cancer Risk with Focus on Possible Determinants - A Systematic Review and a Meta-Analysis

Science.gov (United States)

Starup-Linde, Jakob; Karlstad, Øystein; Eriksen, Stine Aistrup; Vestergaard, Peter; Bronsveld, Heleen K.; de Vries, Frank; Andersen, Morten; Auvinen, Anssi; Haukka, Jari; Hjellvik, Vidar; Bazelier, Marloes T.; de Boer, Anthonius; Furu, Kari; De Bruin, Marie L.

2013-01-01

Background: Patients suffering from diabetes mellitus (DM) may experience an increased risk of cancer; however, it is not certain whether this effect is due to diabetes per se. Objective: To examine the association between DM and cancers by a systematic review and meta-analysis according to the PRISMA guidelines. Data Sources: The systematic literature search includes Medline at PubMed, Embase, Cinahl, Bibliotek.dk, Cochrane library, Web of Science and SveMed+ with the search terms: “Diabetes mellitus”, “Neoplasms”, and “Risk of cancer”. Study Eligibility Criteria: The included studies compared the risk of cancer in diabetic patients versus non-diabetic patients. All types of observational study designs were included. Results: Diabetes patients were at a substantially increased risk of liver (RR=2.1), and pancreas (RR=2.2) cancer. Modestly elevated significant risks were also found for ovary (RR=1.2), breast (RR=1.1), cervix (RR=1.3), endometrial (RR=1.4), several digestive tract (RR=1.1-1.5), kidney (RR=1.4), and bladder cancer (RR=1.1). The findings were similar for men and women, and unrelated to study design. Meta-regression analyses showed limited effect modification of body mass index, and possible effect modification of age, gender, with some influence of study characteristics (population source, cancer- and diabetes ascertainment). Limitations: Publication bias seemed to be present. Only published data were used in the analyses. Conclusions: The systematic review and meta-analysis confirm the previous results of increased cancer risk in diabetes and extend this to additional cancer sites. Physicians in contact with patients with diabetes should be aware that diabetes patients are at an increased risk of cancer. PMID:24215312

Residential Segregation, Housing Status, and Prostate Cancer in African American and White Men

Science.gov (United States)

2008-04-01

estimated that pan frying and chicken are the cooking method and meat that comprise the primary source of dietary PhIP exposure in American men (15,28), but...of cooking temperature on the formation of heterocyclic amines in fried meat products and pan residues. Carcinogenesis 1995;16:861–7. [PubMed: 7728968...6) and stomach cancer (7), intake of fried meat increased lung cancer risk (8), and higher estimated HCA intake increased breast cancer risk (9). A

Lineær programmering med Excel

DEFF Research Database (Denmark)

Lynggaard, Peter

Publikationen giver en introduktion til faget "Lineær programmering". Formulering og løsning bygger på, at modellerne opstilles og løses i et Excel-regneark. Fremgangsmåden er forklaret trin for trin, således at hæftet kan bruges som selvstudiemateriale. Indholdsfortegnelse Generelt om styring og...... planlægning Lineær programmering Excel solveren Fortolkning af udskrifter Degeneration Excel tips Opgaver med løsninger...

9 ikke-narkotikapolitiske faktorer med beskyttende indflydelse

DEFF Research Database (Denmark)

Jourdan, Michael

2007-01-01

Sverige er verdensmester i lav prævalens. Det kan skyldes den førte narkotikapolitik. Men det kan i følge Tim Boekhut van Solinge også skyldes ikke narkotikapolitiske faktorer med beskyttende indflydelse. 9 sådanne præsenteres byggende på bogen: 'The Swedish System - an in-depth review and analysis...

Tosprogede børns møde med metafiktion i en postmoderne billedbog

DEFF Research Database (Denmark)

Daugaard, Line Møller; Johansen, Martin Blok

2012-01-01

casestudium af tosprogede børns møde med en postmoderne billedbog med tydelige metafiktive træk. I vandringerne gennem bogen demonstrerer mange tosprogede børn en høj grad af litterær kompetence. De omgås bogens metafiktive træk med stor faglig sikkerhed og efterspørger bøger, som udfordrer dem og bryder med...... deres forventninger som læsere. På den baggrund opfordres der til, at postmoderne billedbøger udgør en del af tilbuddet til tosprogede børn. When teachers and school librarians choose picture books for bilingual children, they often base their choice on an evaluation of linguistic comprehensibility...... of the bilingual children demonstrate a high level of literary competence. They deal with the book’s metafictional features with great confidence and explicitly call for books which challenge them and break with their expectations as readers. Consequently, it is argued that postmodern picture books should be part...

Med5(Nut1) and Med17(Srb4) Are Direct Targets of Mediator Histone H4 Tail Interactions

Science.gov (United States)

Liu, Zhongle; Myers, Lawrence C.

2012-01-01

The Mediator complex transmits activation signals from DNA bound transcription factors to the core transcription machinery. In addition to its canonical role in transcriptional activation, recent studies have demonstrated that S. cerevisiae Mediator can interact directly with nucleosomes, and their histone tails. Mutations in Mediator subunits have shown that Mediator and certain chromatin structures mutually impact each other structurally and functionally in vivo. We have taken a UV photo cross-linking approach to further delineate the molecular basis of Mediator chromatin interactions and help determine whether the impact of certain Mediator mutants on chromatin is direct. Specifically, by using histone tail peptides substituted with an amino acid analog that is a UV activatible crosslinker, we have identified specific subunits within Mediator that participate in histone tail interactions. Using Mediator purified from mutant yeast strains we have evaluated the impact of these subunits on histone tail binding. This analysis has identified the Med5 subunit of Mediator as a target for histone tail interactions and suggests that the previously observed effect of med5 mutations on telomeric heterochromatin and silencing is direct. PMID:22693636

Correlates of self-rated attachment in cancer patients and their caregivers

DEFF Research Database (Denmark)

Nissen, Kathrine Grovn

2016-01-01

Background: This study aimed to evaluate the association between an anxious/avoidant attachmentstyle and psychosocial variables in patients with cancer and their caregivers.Methods: PsycINFO, PubMed, Google Scholar, and SCOPUS were searched for empirical studiespublished in peer-reviewed journals...

Senior medical students' appraisal of CanMEDS competencies.

NARCIS (Netherlands)

Rademakers, J.; Rooy, N. de; Cate, O.T.J. ten

2007-01-01

CONTEXT: In 2003 the Dutch Central College of Medical Specialties presented guidelines for the modernisation of all medical specialty training programmes in the Netherlands. These guidelines are based to a large extent on the CanMEDS (Canadian Medical Education Directives for Specialists) 2000

Information architecture: study and analysis of data Public Medical base (PubMed

Directory of Open Access Journals (Sweden)

Odete Máyra Mesquita Sales

2016-07-01

Full Text Available Objective. Based on principles proposed by Rosenfeld and Morville (2006, the present study examined the PubMed database interface, since a well-structured information architecture contributes to good usability in any digital environment. Method. The research development occurred through the use of literature techniques and empirical study on the analysis of information architecture based on organization, navigation, recommended labeling and search for Rosenfeld and Morville (2006 for the sake of usability base PubMed. For better understanding and description of these principles, we used the technique of content analysis. Results. The results showed that the database interface meets the criteria established by the elements of Information Architecture, such as organization based on hypertext structure, horizontal menu and local content divided into categories, identifying active links, global navigation , breadcrumb, textual labeling and iconographic and highlight the search engine. Conclusions. This research showed that the PubMed database interface is well structured, friendly and objective, with numerous possibilities of search and information retrieval. However, there is a need to adopt accessibility standards on this website, so that it reaches more efficiently its purpose of facilitating access to information organized and stored in the PubMed database.

Cardiopulmonary resuscitation in palliative care cancer patients.

Science.gov (United States)

Kjørstad, Odd Jarle; Haugen, Dagny Faksvåg

2013-02-19

The criteria for refraining from cardiopulmonary resuscitation in palliative care cancer patients are based on patients' right to refuse treatment and the duty of the treating personnel not to exacerbate their suffering and not to administer futile treatment. When is cardiopulmonary resuscitation futile in these patients? Systematic literature searches were conducted in PubMed for the period 1989-2010 on the results of in-hospital cardiopulmonary resuscitation in advanced cancer patients and on factors that affected the results of CPR when special mention was made of cancer. The searches yielded 333 hits and 18 included articles: four meta-analyses, eight retrospective clinical studies, and six review articles. Cancer patients had a poorer post-CPR survival than non-cancer patients. Survival declined with increasing extent of the cancer disease. Widespread and therapy-resistant cancer disease coupled with a performance status lower than WHO 2 or a PAM score (Pre-Arrest Morbidity Index) of above 8 was regarded as inconsistent with survival after cardiopulmonary resuscitation. Cardiopulmonary resuscitation is futile for in-hospital cancer patients with widespread incurable disease and poor performance status.

Meta-analysis of the Alpha/Beta Ratio for Prostate Cancer in the Presence of an Overall Time Factor

DEFF Research Database (Denmark)

Vogelius, Ivan R; Bentzen, Søren M

2013-01-01

PURPOSE: To present a novel method for meta-analysis of the fractionation sensitivity of tumors as applied to prostate cancer in the presence of an overall time factor. METHODS AND MATERIALS: A systematic search for radiation dose-fractionation trials in prostate cancer was performed using PubMed...

Global surveillance of emerging diseases: the ProMED-mail perspective Vigilância global de doenças emergentes: a perspectiva da ProMED-mail

Directory of Open Access Journals (Sweden)

John P. Woodall

2001-01-01

Full Text Available The Internet is changing the way global disease surveillance is conducted. Countries and international organizations are increasingly placing their outbreak reports on the Internet, which speeds up distribution and therefore prevention and control. The World Health Organization (WHO has recognized the value of nongovernmental organizations and the media in reporting outbreaks, which it then attempts to verify through its country offices. However, WHO and other official sources are constrained in their reporting by the need for bureaucratic clearance. ProMED-mail has no such constraints, and posts outbreak reports 7 days a week. It is moderated by infectious disease specialists who add relevant comments. Thus, ProMED-mail complements official sources and provides early warning of outbreaks. Its network is more than 20,000 people in over 150 countries, who place their computers and time at the network's disposal and report on outbreaks of which they have knowledge. Regions and countries could benefit from adopting the ProMED-mail approach to complement their own disease surveillance systems.A Internet está mudando a condução da vigilância global de doenças. Cada vez mais, os países e as organizações internacionais estão divulgando seus informes na Internet, o que acelera não apenas a distribuição desta informação, como também, consequentemente, a prevenção e controle das doenças. A Organização Mundial da Saúde (OMS já reconheceu a importância das ONGs e da imprensa na notificação de surtos, que procura verificar posteriormente através de suas agências locais. Entretanto, a OMS e outras fontes oficiais sofrem restrições em seus relatórios pela obrigatoriedade da autorização burocrática, além de só publicarem informes nos dias úteis. A ProMED-mail não está sujeita a tais restrições. A rede é moderada por especialistas em doenças infecciosas, que acrescentam comentários relevantes. Assim, a ProMED

[Limiting a Medline/PubMed query to the "best" articles using the JCR relative impact factor].

Science.gov (United States)

Avillach, P; Kerdelhué, G; Devos, P; Maisonneuve, H; Darmoni, S J

2014-12-01

Medline/PubMed is the most frequently used medical bibliographic research database. The aim of this study was to propose a new generic method to limit any Medline/PubMed query based on the relative impact factor and the A & B categories of the SIGAPS score. The entire PubMed corpus was used for the feasibility study, then ten frequent diseases in terms of PubMed indexing and the citations of four Nobel prize winners. The relative impact factor (RIF) was calculated by medical specialty defined in Journal Citation Reports. The two queries, which included all the journals in category A (or A OR B), were added to any Medline/PubMed query as a central point of the feasibility study. Limitation using the SIGAPS category A was larger than the when using the Core Clinical Journals (CCJ): 15.65% of PubMed corpus vs 8.64% for CCJ. The response time of this limit applied to the entire PubMed corpus was less than two seconds. For five diseases out of ten, limiting the citations with the RIF was more effective than with the CCJ. For the four Nobel prize winners, limiting the citations with the RIF was more effective than the CCJ. The feasibility study to apply a new filter based on the relative impact factor on any Medline/PubMed query was positive. Copyright © 2014 Elsevier Masson SAS. All rights reserved.

Kommunikation ved brug af mobile enheder med digital video i idræt

DEFF Research Database (Denmark)

Langagergaard Rødbro, Lise; Elbæk, Lars

2012-01-01

I artiklen redegøres kort for et projekt, som førte frem til en videoplatform, der er et bud på et ’lukket YouTube’, hvor video filmet med smartphone direkte kan uploades til, og med funktioner specifikt udviklet til skolens idrætsundervisning. Med afsæt i systemisk kommunikationsteori analyseres...... observations- og interviewda-ta for at belyse den kommunikation, der foregår ved brug af platformen. Senere diskuteres resultaterne ud fra kommunikationstrekanten, og der skitseres en model for videostøttet undervisning i idræt ud fra Batesons kommunikations- og læringsniveauer. Gennem analyser af platformens...

Er nogle af de udfordrende aspekter af CanMEDS-rollerne valide uden for Canada? Undersøgelse af validiteten af vaesentlige elementer i CanMEDS-rollebeskrivelserne

DEFF Research Database (Denmark)

Ringsted, Charlotte V; Hansen, Torben Lindskov; Davis, Deborah

2007-01-01

groups' evaluation of importance and confidence were evident. This study provides an outline of the validity of the CanMEDS roles in a non-Canadian setting. More research in how these aspects of competence are best taught across countries and specialties is needed. Udgivelsesdato: 2007-Jun-11......A questionnaire survey among 8749 Danish physicians about how the CanMEDS roles apply in an international context. Response rate 42.8% (3,476). The mean rating of importance of competence was 4.2 (SD 0.6). Ratings of confidence increased from interns to specialists. Differences between specialty...

Management of data from clinical trials using the ArchiMed system.

Science.gov (United States)

Duftschmid, Georg; Gall, Walter; Eigenbauer, Ernst; Dorda, Wolfgang

2002-06-01

Clinical trials constitute a key source of medical research and are therefore conducted on a regular basis at university hospitals. The professional execution of trials requires, among other things, a repertoire of tools that support efficient data management. Tasks that are essential for efficient data management in clinical trials include the following: the design of the trial database, the design of electronic case report forms, recruiting patients, collection of data, and statistical analysis. The present article reports the manner in which these tasks are supported by the ArchiMed system at the University of Vienna and Graz Medical Schools. ArchiMed is customized for clinical end users, allowing them to autonomously manage their clinical trials without having to consult computer experts. An evaluation of the ArchiMed system in 12 trials recently conducted at the University of Vienna Medical School shows that the individual system functions can be usefully applied for data management in clinical trials.

A survey of etiologic hypotheses among testicular cancer researchers

DEFF Research Database (Denmark)

Stang, A; Trabert, B; Rusner, C

2015-01-01

Basic research results can provide new ideas and hypotheses to be examined in epidemiological studies. We conducted a survey among testicular cancer researchers on hypotheses concerning the etiology of this malignancy. All researchers on the mailing list of Copenhagen Testis Cancer Workshops...... and corresponding authors of PubMed-indexed articles identified by the search term 'testicular cancer' and published within 10 years (in total 2750 recipients) were invited to respond to an e-mail-based survey. Participants of the 8th Copenhagen Testis Cancer Workshop in May 2014 were subsequently asked to rate...... that scored as most plausible. We also present plans for improving the survey that may be repeated at a next international meeting of experts in testicular cancer. Overall 52 of 99 (53%) registered participants of the 8th Copenhagen Testis Cancer Workshop submitted the plausibility rating form. Fourteen of 27...

Inklusion i folkeskolen med musik og musikterapi

DEFF Research Database (Denmark)

Lindvang, Charlotte

2014-01-01

I denne artikel sættes der fokus på nogle af de problemer og udfordringer som knytter sig til kravet om inklusion af børn med særlige behov i den almindelige folkeskole, og der argumenteres for at styrke anvendelsen af musik i forhold til at skabe fællesskab og optimere børnenes opmærksomhed og...

Does HPV status influence survival after vulvar cancer?

DEFF Research Database (Denmark)

Rasmussen, Christina Louise; Sand, Freja Laerke; Hoffmann Frederiksen, Marie

2018-01-01

High-risk human papillomavirus (HPV) infection is essential in the carcinogenesis of a substantial part of anogenital and oropharyngeal cancers and has additionally been shown to be a possible predictive marker for survival, especially in oropharyngeal cancer. Studies examining the influence of HPV...... status on survival after vulvar cancer have been conflicting and limited by small study populations. Therefore, the aim of this review and meta-analysis was to examine whether HPV status influences survival after vulvar cancer, which, to our knowledge, has not been done before. We conducted a systematic...... search of PubMed, Cochrane Library and Embase to identify studies examining survival after histologically verified and HPV tested vulvar cancer. A total of 18 studies were eligible for inclusion. Study-specific and pooled HRs of the 5-year OS and DFS were calculated using a fixed effects model. The I2...

Forsøg med 4 centralt belastede betonelementer samt 4 tilhørende betoncylindre

DEFF Research Database (Denmark)

Ellegaard, Peter; Hansen, Lars Pilegaard

Nærværende rapport indeholder beskrivelser og resultater for en række forsøg udført i Laboratoriet for Bærende Konstruktioner, Aalborg Universitet. Prøvelegemerne, som er nærmere beskrevet i kapitel 1, består af 4 betonelementer med en længde på 2600 mm og et tværsnitsareal på 400x120 mm. Element......Nærværende rapport indeholder beskrivelser og resultater for en række forsøg udført i Laboratoriet for Bærende Konstruktioner, Aalborg Universitet. Prøvelegemerne, som er nærmere beskrevet i kapitel 1, består af 4 betonelementer med en længde på 2600 mm og et tværsnitsareal på 400x120 mm....... Elementerne er belastet centralt med tryk, og de er forsynet med transportarmering. Til bestemmelse af betonens brudstyrke og arbejdskurve op til 75% af brudstyrken er der udført forsøg på 4betoncylindre med diameter 100 mm og højde 200 mm. Elementerne og cylinderne er fremstillet af Fårup Betonindustri A...

COSMO-SkyMed and GIS applications

Science.gov (United States)

Milillo, Pietro; Sole, Aurelia; Serio, Carmine

2013-04-01

Geographic Information Systems (GIS) and Remote Sensing have become key technology tools for the collection, storage and analysis of spatially referenced data. Industries that utilise these spatial technologies include agriculture, forestry, mining, market research as well as the environmental analysis . Synthetic Aperture Radar (SAR) is a coherent active sensor operating in the microwave band which exploits relative motion between antenna and target in order to obtain a finer spatial resolution in the flight direction exploiting the Doppler effect. SAR have wide applications in Remote Sensing such as cartography, surface deformation detection, forest cover mapping, urban planning, disasters monitoring , surveillance etc… The utilization of satellite remote sensing and GIS technology for this applications has proven to be a powerful and effective tool for environmental monitoring. Remote sensing techniques are often less costly and time-consuming for large geographic areas compared to conventional methods, moreover GIS technology provides a flexible environment for, analyzing and displaying digital data from various sources necessary for classification, change detection and database development. The aim of this work si to illustrate the potential of COSMO-SkyMed data and SAR applications in a GIS environment, in particular a demostration of the operational use of COSMO-SkyMed SAR data and GIS in real cases will be provided for what concern DEM validation, river basin estimation, flood mapping and landslide monitoring.

Udvikling af antistoffer efter vaccination mod og podning med PRRSV

DEFF Research Database (Denmark)

Sonne Kristensen, Charlotte; Qvist Pawlowski, Mia; Thoning, Henrik

konkludere, at det er muligt at vaccinere med begge PRRS vacciner på samme tid og opnå antistofsvar for begge typer PRRSV. Husk dog altid at give forskellige vacciner i hver sin side af nakken. Blodprøver fra grisene viste, at de havde dannet antistoffer og blev positive i ELISA-testen for PRRSV Type 1 21......-US samt IPT testene. Disse tests kan dog ikke skelne ”eksotiske” PRRSV subtyper fra de almindelige cirkulerende PRRSV subtyper i Danmark. Forsøget blev gennemført på Lindholm. Der indgik 66 grise fra en Blå SPF+Ap6+Ap12 besætning. Grisene blev ved ankomst fordelt i 4 grupper (VAC-T1, VAC-T2, VAC-T1T2 og...... NON-VAC): VAC-T1 blev vaccineret med Porcilis ® PRRS VET VAC-T2 blev vaccineret med Ingelvac ® PRRS VET VAC-T1T2 fik begge vacciner samtidig i hver sin side af nakken NON-VAC blev ikke vaccineret. Grisene blev gennem hele forsøget observeret dagligt. De fik taget temperatur den første uge efter...

The cognitive effects of opioids in cancer: a systematic review

DEFF Research Database (Denmark)

Kurita, Geana Paula; Lundorff, Lena; Pimenta, Cibele Andrucioli de Mattos

2008-01-01

OBJECTIVE AND METHODS: In order to better understand the effects of opioids on the cognitive function in cancer pain patients, a literature search was performed in PubMed, EMBASE, PsycInfo, CINAHL and Lilacs databases. Ten controlled trials were selected and classified according to the study design...

Akzo Nobel Science Award: Svensk upptaeckt botar framtidens cancer

CERN Multimedia

2003-01-01

'Akzo Nobel Science Award: Svensk upptaeckt botar framtidens cancerStockholm, 27 februari, 2003. Aarets Akzo Nobel Science Award Sweden paa 500 000 kronor gaar till professorn i medicinsk straalningsfysik Anders Brahme. Han prisas foer "sin unika forskargaerning inom straalbehandlingsysiken samt kombinationen av grundforskning, tillaempad forskning och interaktion med industrin"' (1 page).

OC-2-KB: A software pipeline to build an evidence-based obesity and cancer knowledge base.

Science.gov (United States)

Lossio-Ventura, Juan Antonio; Hogan, William; Modave, François; Guo, Yi; He, Zhe; Hicks, Amanda; Bian, Jiang

2017-11-01

Obesity has been linked to several types of cancer. Access to adequate health information activates people's participation in managing their own health, which ultimately improves their health outcomes. Nevertheless, the existing online information about the relationship between obesity and cancer is heterogeneous and poorly organized. A formal knowledge representation can help better organize and deliver quality health information. Currently, there are several efforts in the biomedical domain to convert unstructured data to structured data and store them in Semantic Web knowledge bases (KB). In this demo paper, we present, OC-2-KB (Obesity and Cancer to Knowledge Base), a system that is tailored to guide the automatic KB construction for managing obesity and cancer knowledge from free-text scientific literature (i.e., PubMed abstracts) in a systematic way. OC-2-KB has two important modules which perform the acquisition of entities and the extraction then classification of relationships among these entities. We tested the OC-2-KB system on a data set with 23 manually annotated obesity and cancer PubMed abstracts and created a preliminary KB with 765 triples. We conducted a preliminary evaluation on this sample of triples and reported our evaluation results.

MED: a new non-supervised gene prediction algorithm for bacterial and archaeal genomes

Directory of Open Access Journals (Sweden)

Yang Yi-Fan

2007-03-01

Full Text Available Abstract Background Despite a remarkable success in the computational prediction of genes in Bacteria and Archaea, a lack of comprehensive understanding of prokaryotic gene structures prevents from further elucidation of differences among genomes. It continues to be interesting to develop new ab initio algorithms which not only accurately predict genes, but also facilitate comparative studies of prokaryotic genomes. Results This paper describes a new prokaryotic genefinding algorithm based on a comprehensive statistical model of protein coding Open Reading Frames (ORFs and Translation Initiation Sites (TISs. The former is based on a linguistic "Entropy Density Profile" (EDP model of coding DNA sequence and the latter comprises several relevant features related to the translation initiation. They are combined to form a so-called Multivariate Entropy Distance (MED algorithm, MED 2.0, that incorporates several strategies in the iterative program. The iterations enable us to develop a non-supervised learning process and to obtain a set of genome-specific parameters for the gene structure, before making the prediction of genes. Conclusion Results of extensive tests show that MED 2.0 achieves a competitive high performance in the gene prediction for both 5' and 3' end matches, compared to the current best prokaryotic gene finders. The advantage of the MED 2.0 is particularly evident for GC-rich genomes and archaeal genomes. Furthermore, the genome-specific parameters given by MED 2.0 match with the current understanding of prokaryotic genomes and may serve as tools for comparative genomic studies. In particular, MED 2.0 is shown to reveal divergent translation initiation mechanisms in archaeal genomes while making a more accurate prediction of TISs compared to the existing gene finders and the current GenBank annotation.

Cardiomyocyte-Specific Ablation of Med1 Subunit of the Mediator Complex Causes Lethal Dilated Cardiomyopathy in Mice.

Science.gov (United States)

Jia, Yuzhi; Chang, Hsiang-Chun; Schipma, Matthew J; Liu, Jing; Shete, Varsha; Liu, Ning; Sato, Tatsuya; Thorp, Edward B; Barger, Philip M; Zhu, Yi-Jun; Viswakarma, Navin; Kanwar, Yashpal S; Ardehali, Hossein; Thimmapaya, Bayar; Reddy, Janardan K

2016-01-01

Mediator, an evolutionarily conserved multi-protein complex consisting of about 30 subunits, is a key component of the polymerase II mediated gene transcription. Germline deletion of the Mediator subunit 1 (Med1) of the Mediator in mice results in mid-gestational embryonic lethality with developmental impairment of multiple organs including heart. Here we show that cardiomyocyte-specific deletion of Med1 in mice (csMed1-/-) during late gestational and early postnatal development by intercrossing Med1fl/fl mice to α-MyHC-Cre transgenic mice results in lethality within 10 days after weaning due to dilated cardiomyopathy-related ventricular dilation and heart failure. The csMed1-/- mouse heart manifests mitochondrial damage, increased apoptosis and interstitial fibrosis. Global gene expression analysis revealed that loss of Med1 in heart down-regulates more than 200 genes including Acadm, Cacna1s, Atp2a2, Ryr2, Pde1c, Pln, PGC1α, and PGC1β that are critical for calcium signaling, cardiac muscle contraction, arrhythmogenic right ventricular cardiomyopathy, dilated cardiomyopathy and peroxisome proliferator-activated receptor regulated energy metabolism. Many genes essential for oxidative phosphorylation and proper mitochondrial function such as genes coding for the succinate dehydrogenase subunits of the mitochondrial complex II are also down-regulated in csMed1-/- heart contributing to myocardial injury. Data also showed up-regulation of about 180 genes including Tgfb2, Ace, Atf3, Ctgf, Angpt14, Col9a2, Wisp2, Nppa, Nppb, and Actn1 that are linked to cardiac muscle contraction, cardiac hypertrophy, cardiac fibrosis and myocardial injury. Furthermore, we demonstrate that cardiac specific deletion of Med1 in adult mice using tamoxifen-inducible Cre approach (TmcsMed1-/-), results in rapid development of cardiomyopathy and death within 4 weeks. We found that the key findings of the csMed1-/- studies described above are highly reproducible in TmcsMed1-/- mouse heart

Medical dictionary MedDRA: Used in over 60 countries, among which is Montenegro

Directory of Open Access Journals (Sweden)

Mugoša Snežana S.

2015-01-01

Full Text Available Introduction: Medical Dictionary for Regulatory Activities (MedDRA is a medical coding dictionary which is designed in order to be used by regulatory authorities, pharmaceutical companies, clinical research organizations and health care professionals, i.e. all participants in the system of medicines safety monitoring. Methods: This article describes process which is used for medical coding in clinical data management and, in brief, most commonly used medical dictionary MedDRA. The purpose of this paper is a modest contribution to easier and more successful understanding of the encoding process in clinical data management in the field of pharmacovigilance. Topic: MedDRA Development, structure, multi-axiality, availability of foreign languages, as well as common problems faced by medical coding expert while coding were presented. Conclusion: MedDRA has become the standard medical terminology for drug regulators and pharmaceutical companies in Montenegro. Training should be provided to all coders in order to achieve the optimum level of coding and to ensure that all the parameters for quality are achieved. Coding should be treated as one of the most important function in clinical research.

Multi-lingual search engine to access PubMed monolingual subsets: a feasibility study.

Science.gov (United States)

Darmoni, Stéfan J; Soualmia, Lina F; Griffon, Nicolas; Grosjean, Julien; Kerdelhué, Gaétan; Kergourlay, Ivan; Dahamna, Badisse

2013-01-01

PubMed contains many articles in languages other than English but it is difficult to find them using the English version of the Medical Subject Headings (MeSH) Thesaurus. The aim of this work is to propose a tool allowing access to a PubMed subset in one language, and to evaluate its performance. Translations of MeSH were enriched and gathered in the information system. PubMed subsets in main European languages were also added in our database, using a dedicated parser. The CISMeF generic semantic search engine was evaluated on the response time for simple queries. MeSH descriptors are currently available in 11 languages in the information system. All the 654,000 PubMed citations in French were integrated into CISMeF database. None of the response times exceed the threshold defined for usability (2 seconds). It is now possible to freely access biomedical literature in French using a tool in French; health professionals and lay people with a low English language may find it useful. It will be expended to several European languages: German, Spanish, Norwegian and Portuguese.

På kant med naturen - om byøkologien og det åbne land

DEFF Research Database (Denmark)

Schjerup Hansen, J.(red.); Hjortholt Madsen, S.(red.)

Den erkendelse, at vores produktionsmåde og levevis i høj grad har bragt os på kant med naturen og på lidt længere sigt på kant med vort eget eksistensgrundlag, breder sig. En samfundsmæssig selvreflektion har allerede udmøntet sig i begreber som renere teknologi, byøkologi og bæredygtig adfærd. I...... tidens selvreflektion ligger, at vort forhold til naturen i høj grad er et "indre anliggende": Vi er selv natur, og det er vores egen måde at tænke og handle på i forhold til naturen, der har bragt os på kant med naturen - og os selv....

Cell-Free DNA in Metastatic Colorectal Cancer

DEFF Research Database (Denmark)

Spindler, Karen-Lise G.; Boysen, Anders K.; Pallisgard, Niels

2017-01-01

-analysis of the prognostic value of total cfDNA in patients with metastatic colorectal cancer (mCRC) treated with chemotherapy. In addition, we report on the overall performance of cfDNA as source for KRAS mutation detection. MATERIALS AND METHODS: A systematic literature search of PubMed and Embase was performed by two......BACKGROUND: Circulating DNA can be detected and quantified in the blood of cancer patients and used for detection of tumor-specific genetic alterations. The clinical utility has been intensively investigated for the past 10 years. The majority of reports focus on analyzing the clinical potential...

Associations of Mediterranean Diet and a Posteriori Derived Dietary Patterns with Breast and Lung Cancer Risk: A Case-Control Study.

Science.gov (United States)

Krusinska, Beata; Hawrysz, Iwona; Wadolowska, Lidia; Slowinska, Malgorzata Anna; Biernacki, Maciej; Czerwinska, Anna; Golota, Janusz Jacek

2018-04-11

Lung cancer in men and breast cancer in women are the most commonly diagnosed cancers in Poland and worldwide. Results of studies involving dietary patterns (DPs) and breast or lung cancer risk in European countries outside the Mediterranean Sea region are limited and inconclusive. This study aimed to develop a 'Polish-adapted Mediterranean Diet' ('Polish-aMED') score, and then study the associations between the 'Polish-aMED' score and a posteriori -derived dietary patterns with breast or lung cancer risk in adult Poles. This pooled analysis of two case-control studies involved 560 subjects (280 men, 280 women) aged 40-75 years from Northeastern Poland. Diagnoses of breast cancer in 140 women and lung cancer in 140 men were found. The food frequency consumption of 21 selected food groups was collected using a 62-item Food Frequency Questionnaire (FFQ)-6. The 'Polish-adapted Mediterranean Diet' score which included eight items-vegetables, fruit, whole grain, fish, legumes, nuts and seeds-as well as the ratio of vegetable oils to animal fat and red and processed meat was developed (range: 0-8 points). Three DPs were identified in a Principal Component Analysis: 'Prudent', 'Non-healthy', 'Dressings and sweetened-low-fat dairy'. In a multiple logistic regression analysis, two models were created: crude, and adjusted for age, sex, type of cancer, Body Mass Index (BMI), socioeconomic status (SES) index, overall physical activity, smoking status and alcohol abuse. The risk of breast or lung cancer was lower in the average (3-5 points) and high (6-8 points) levels of the 'Polish-aMED' score compared to the low (0-2 points) level by 51% (odds ratio (OR): 0.49; 95% confidence interval (Cl): 0.30-0.80; p Mediterranean diet could be considered for adults living in non-Mediterranean countries for the prevention of the breast or lung cancers. Future studies should explore the role of a traditional Mediterranean diet fitted to local dietary patterns of non-Mediterranean Europeans

Using data sources beyond PubMed has a modest impact on the results of systematic reviews of therapeutic interventions.

Science.gov (United States)

Halladay, Christopher W; Trikalinos, Thomas A; Schmid, Ian T; Schmid, Christopher H; Dahabreh, Issa J

2015-09-01

Searching multiple sources when conducting systematic reviews is considered good practice. We aimed to investigate the impact of using sources beyond PubMed in systematic reviews of therapeutic interventions. We randomly selected 50 Cochrane reviews that searched the PubMed (or MEDLINE) and EMBASE databases and included a meta-analysis of ≥10 studies. We checked whether each eligible record in each review (n = 2,700) was retrievable in PubMed and EMBASE. For the first-listed meta-analysis of ≥10 studies in each review, we examined whether excluding studies not found in PubMed affected results. A median of one record per review was indexed in EMBASE but not in PubMed; a median of four records per review was not indexed in PubMed or EMBASE. Meta-analyses included a median of 13.5 studies; a median of zero studies per meta-analysis was indexed in EMBASE but not in PubMed; a median of one study per meta-analysis was not indexed in PubMed or EMBASE. Meta-analysis using only PubMed-indexed vs. all available studies led to a different conclusion in a single case (on the basis of conventional criteria for statistical significance). In meta-regression analyses, effects in PubMed- vs. non-PubMed-indexed studies were statistically significantly different in a single data set. For systematic reviews of the effects of therapeutic interventions, gains from searching sources beyond PubMed, and from searching EMBASE in particular are modest. Copyright © 2015 Elsevier Inc. All rights reserved.

Opfølgende hjemmebesøg med video

DEFF Research Database (Denmark)

Wentzer, Helle

Denne publikation beskriver erfaringerne fra et udviklingsprojekt, hvor opfølgende hjemmebesøg kombineres med videokonference-teknologi. Projektet har bestået i at gennemføre et eksperiment, hvor video benyttes til at mediere samtalen mellem læge, hjemmesygeplejerske og den ældre medicinske patie...

Fra interne udviklingsplaner til åben innovation med brug af Web 2.0 teknologi

DEFF Research Database (Denmark)

Scupola, Ada; Sørensen, Flemming; Nicolajsen, Hanne Westh

Abstrakt: Artiklen handler om brugerinddragelse i service innovation. Der er fokus på idéfasen kombineret med anvendelse af kommunikationsteknologi og i særdeleshed webblogmediet. Behov som kreativitet, heterogenitet, engagement med mere diskuteres. Der afrapporteres fra et eksperiment på Roskild...

Archives of Breast Cancer: An Academic Multidisciplinary Breast Cancer Forum

Directory of Open Access Journals (Sweden)

Ahmad Kaviani

2014-05-01

Full Text Available Welcome to Archives of Breast Cancer (ABC, a new journal with sole focus on breast diseases and especially breast cancer. Breast cancer is a devastating disease that impacts many women and threatens their health and wellbeing. A large number of health professionals from a wide spectrum of clinical disciplines, such as surgery, medical oncology, public health, pathology, radiation oncology, diagnostic radiology, and nuclear medicine, are involved in dealing with such a challenging and common disease.The concept of applying a multidisciplinary approach to clinical and non-clinical aspects of breast cancer has been found to be of vital importance to the understanding of this prevalent type of cancer. Such collaboration can also improve the quantity and quality of the research in this field. To this end, journals which choose to publish multidisciplinary articles as their primary focus can serve as the academic forum to share ideas from a variety of expertise. Archives of Breast Cancer can certainly add to the depth and quality of the research in the field. Articles on a single topic would be readily available to the readers from multiple disciplines and all in one journal. This would eventually lead to fruitful interaction among specialists seeking to investigate this disease, yet,from different perspectives. The benefits of this interaction in the process of devising appropriate strategies and approaches in dealing with the problem are crystal clear.The world of medical sciences has witnessed an abundant increase in the quality and quantity of breast-cancer-related research. In the past 20 years, the number of published articles indexed in PubMed from 1994 to 2014 is more than 5 times than the number published before 1993 (about 170,000 compared to 30,000. Meanwhile, the number of PubMed indexed medical journals dedicated to breast cancer research has also risen from 5 in 1993 to 17 in 2014. This increasing trend highlights an essential need for

Prostate cancer, treatment modalities and complications: an evaluation of the scientific literature

International Nuclear Information System (INIS)

Santos-Filho, Sebastiao David; Fonseca, Adenilson de Souza da; Bernardo-Filho, Mario; Missailids, Sotiris

2008-01-01

Prostate (PR) cancer (CA) is one of the most common malignant neoplasms in men all over the world. In general, if prostate cancer (PC) is detected early, treatment usually involves either surgical removal of the prostate or radiotherapy (RT). Hormone Therapy (HT) or chemotherapy (CH) is the preferred treatment for more advanced cases of PC or if CA spreads beyond the PT. A number of complications, such as urinary incontinence (IU) or erectile dysfunction (ED), can be associated with some modalities of treatment of the PC. The aim of this work is to evaluate, in PubMed, the number of publications related with prostate cancer and the main modalities of treatment, as well as some clinical complications. The searches were performed in PubMed (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi) in the period 1950 to 2008 using the words: CA, CA and PR or penis or testis, CA and PR and RT, CA and PR and surgery (SU), CA and PR and CH and, CA and PR and HT and CA and PR and RT and IU or ED, CA and PR and SU and IU or ED, CA and PR and CH and IU or ED and, CA and PR and HT and CH and IU or ED, and (V) PC and the same modalities of treatment. The data was obtained on July 20th, 2008. PC, as expected has been cited extensively and surgery has been identified as the most widely referenced modality of treatment. Furthermore, urinary incontinence and erectile dysfunction are important complications that have attracted significant scientific interest. In conclusion, these findings have shown the relevance of the PubMed to analyze quantitatively the publications in cancer and this information could be worthwhile in aiding the comprehension of some clinical aspects related with PC, as well as the development of preventative actions. The analysis of the scientific interest, considering the number of publications in the PubMed, reveals research trends in the field and demonstrates the importance of the surgical procedures in the treatment of the prostate cancer. Moreover, this finding is

Prostate cancer, treatment modalities and complications: an evaluation of the scientific literature

Energy Technology Data Exchange (ETDEWEB)

Santos-Filho, Sebastiao David; Fonseca, Adenilson de Souza da; Bernardo-Filho, Mario [Universidade do Estado do Rio de Janeiro (UERJ), RJ (Brazil). Inst. de Biologia Roberto Alcantara Gomes. Dept. de Biofisica e Biometria]. E-mail: santos-filho@uer.br; Missailids, Sotiris [The Open University, Milton Keynes (United Kingdom). Dept. of Chemistry and Analytical Sciences

2008-12-15

Prostate (PR) cancer (CA) is one of the most common malignant neoplasms in men all over the world. In general, if prostate cancer (PC) is detected early, treatment usually involves either surgical removal of the prostate or radiotherapy (RT). Hormone Therapy (HT) or chemotherapy (CH) is the preferred treatment for more advanced cases of PC or if CA spreads beyond the PT. A number of complications, such as urinary incontinence (IU) or erectile dysfunction (ED), can be associated with some modalities of treatment of the PC. The aim of this work is to evaluate, in PubMed, the number of publications related with prostate cancer and the main modalities of treatment, as well as some clinical complications. The searches were performed in PubMed (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi) in the period 1950 to 2008 using the words: CA, CA and PR or penis or testis, CA and PR and RT, CA and PR and surgery (SU), CA and PR and CH and, CA and PR and HT and CA and PR and RT and IU or ED, CA and PR and SU and IU or ED, CA and PR and CH and IU or ED and, CA and PR and HT and CH and IU or ED, and (V) PC and the same modalities of treatment. The data was obtained on July 20th, 2008. PC, as expected has been cited extensively and surgery has been identified as the most widely referenced modality of treatment. Furthermore, urinary incontinence and erectile dysfunction are important complications that have attracted significant scientific interest. In conclusion, these findings have shown the relevance of the PubMed to analyze quantitatively the publications in cancer and this information could be worthwhile in aiding the comprehension of some clinical aspects related with PC, as well as the development of preventative actions. The analysis of the scientific interest, considering the number of publications in the PubMed, reveals research trends in the field and demonstrates the importance of the surgical procedures in the treatment of the prostate cancer. Moreover, this finding is

Folkeskolens opgaver overfor børn med forskellig social, etnisk og kultur baggrund

DEFF Research Database (Denmark)

Tireli, Üzeyir

2012-01-01

Med udgangspukt i en case om romapige fremhæves det, at skolen og lærerne stigmatiserer elever med en anden baggrund end etnisk dansk. Det betyder, at skolen i fremtiden står overfor en stor ligestillingsopgave, da prognoser tyder på øget indvandring. Der kan derfor let opstår øgede forskelle mel...

Comparative study of MR imaging and X-ray in Med-anemia

International Nuclear Information System (INIS)

Huang Zhongkui; Long Liling; Song Yingru

2002-01-01

Objective: To evaluate the diagnostic value of MRI and X-ray and to analyze MRI and X-ray characteristics in Med-anemia. Methods: MRI was performed in thoracic spine, lumbar spine, sacral spine, pelvis, and superior femurs in 15 patients with pathologically proved Med-anemia with T 1 WI and T 2 WI. Seven of them were examined on X-ray. Twenty volunteers were examined on MR as control group. The authors analyzed the manifestations of MRI in the Med-anemia, including abnormality of signal intensity of bone marrow, T 1 value, vertebral alteration of size and shaped, spinal cord compression due to epidural extramedullary haematopoiesis, and compared with the findings of bone on X-ray. Results: In the control group, bone marrow showed an inhomogeneous iso-signal intensity with band-shaped, triangular or motley high signal intensity in the middle or back part of the vertebra, neck of the femur on T 1 WI and a homogeneous iso-signal intensity on T 2 WI in the vertebra, pelvis, and superior femur. All cases with Med-anemia had low homogenous signal intensity in the bone marrow of the vertebra, pelvis and superior femur on T 1 WI but had no alterations on T 2 WI. The spinal cord was constricted resulting from protruding crushed vertebra with bullet-like shape in 4 cases. The soft tissue masses, confirmed as extramedullary haematopoiesis by operation, were demonstrated in 4 cases. Among 7 cases with X-ray examinations, 2 cases showed normal on X-ray but abnormal bone marrow on MRI, another 5 cases demonstrated bone alteration including osteoporosis, widening of striations, enlargement of ribs and vertebras. T 1 value showed (897.4 +- 75.43) ms in the Med- anemia group and (401.5 +- 28.1) ms in the control group with significant statistical difference (P 1 WI; (2) MRI is useful in demonstrating the space occupying lesion due to vertebral deformity, enlargement of ribs and extramedullary haematopoiesis

Med5(Nut1 and Med17(Srb4 are direct targets of mediator histone H4 tail interactions.

Directory of Open Access Journals (Sweden)

Zhongle Liu

Full Text Available The Mediator complex transmits activation signals from DNA bound transcription factors to the core transcription machinery. In addition to its canonical role in transcriptional activation, recent studies have demonstrated that S. cerevisiae Mediator can interact directly with nucleosomes, and their histone tails. Mutations in Mediator subunits have shown that Mediator and certain chromatin structures mutually impact each other structurally and functionally in vivo. We have taken a UV photo cross-linking approach to further delineate the molecular basis of Mediator chromatin interactions and help determine whether the impact of certain Mediator mutants on chromatin is direct. Specifically, by using histone tail peptides substituted with an amino acid analog that is a UV activatible crosslinker, we have identified specific subunits within Mediator that participate in histone tail interactions. Using Mediator purified from mutant yeast strains we have evaluated the impact of these subunits on histone tail binding. This analysis has identified the Med5 subunit of Mediator as a target for histone tail interactions and suggests that the previously observed effect of med5 mutations on telomeric heterochromatin and silencing is direct.

Targeted Zinc Delivery: A Novel Treatment for Prostate Cancer

Science.gov (United States)

2010-06-01

consumption, such as that which affects more than 10% of the US population, to such diseases as anorexia nervosa, Ahlzeimer’s Disease, and cancer. Several...Med 1996, 125(2):142-144. 4. Heshmat MY, Kaul L, Kovi J, Jackson MA, Jackson AG, Jones GW, Edson M, Enterline JP, Worrell RG, Perry SL: Nutrition

Med hjerne og hjerte - et aktionsforskningsprojekt om demensomsorg

DEFF Research Database (Denmark)

Hansen, Helle Krogh; Rasmussen, Else Marie

om værdier; individuelle interviews (8 pårørende og 3 frivillige); to kernekvalitetsundersøgelser (4 medarbejdere undersøgte kvaliteter og værdier ud fra D. Ofmans teori om kernekvaliteter); en kernekvalitetsundersøgelse i samarbejde med lederen; SWOT-analyser, udarbejdelse og analyse af...

Aktiv online læring med E-tiviteter

DEFF Research Database (Denmark)

Schneider, Maria Viftrup

Designe e-tiviteter i vidensøgning og dertilhørende læringsobjekter. Udvikling af didaktikken ift blended learning., med anvendelse af Gilly Salmons E-tivities model som ramme for design af studieaktiviteter. Læringsprodukter hører under læringskoncepterne Undervisningsloop, Peer assessment og Fl...... Flipped classroom....

Radiotherapy, cancer and some anatomical structures related with the pelvic floor: an evaluation of the scientific literature

Energy Technology Data Exchange (ETDEWEB)

Santos-Filho, Sebastiao David; Fonseca, Adenilson de Souza da; Bernardo-Filho, Mario [Universidade do Estado do Rio de Janeiro (UERJ), RJ (Brazil). Inst. de Biologia Roberto Alcantara Gomes. Dept. de Biofisica e Biometria; Presta, Giuseppe Antonio [Universidade Federal do Rio de Janeiro (UFRJ), RJ (Brazil). Inst. Biomedico. Dept. de Fisiologia Humana; Paoli, Severo de [Centro Universitario Serra dos Orgaos, Teresopolis, RJ (Brazil). Centro de Ciencias da Saude; Missailids, Sotiris [The Open University, Milton Keynes (United Kingdom). Dept. of Chemistry and Analytical Sciences

2008-12-15

Radiotherapy is a cancer treatment that uses high-energy X-rays or other types of ionizing radiation to try to kill the cancer cells in various organs/tissues. PubMed is a database used as a tool in various publications. The aim of this work was to evaluate, in the PubMed, the number of publications (NP) in radiotherapy and cancer in various organs related to the pelvic floor as well as brachytherapy. The searches were performed (August 2008) in the PubMed (http://www.pubmed.com) using the words: radiotherapy (RT) or cancer (CA), RT and CA, RT and CA and prostate, RT and CA and testis, RT and CA and breast, RT and CA and kidneys, RT and CA and vulva, RT and CA and vagina, RT and CA and penis, RT and CA and uterus, RT and CA and ovary, RT and CA and bladder, and RT and CA and urethra. A search using brachytherapy was also performed. The NP in each subject was determined and was 2178635 to CA and about 9% of them are related with RT. The NP in RT and CA and breast or prostate is bigger than for the other organs, whereas brachytherapy is mainly cited in the studies about CA of prostate, bladder and breast. In conclusion, our findings demonstrate the importance of radiation therapy studies in the cancer of several organs. This information is crucial in understanding the field and demonstrates areas of significant progress or existing gaps of research in radiotherapy treatment of various cancers of the pelvis. Furthermore, it could significantly aid the interprofessional team in the determination of actions related to the treatment of patients that are undertaking radiotherapy, due to the possible complications of this modality of treatment. (author)

Radiotherapy, cancer and some anatomical structures related with the pelvic floor: an evaluation of the scientific literature

International Nuclear Information System (INIS)

Santos-Filho, Sebastiao David; Fonseca, Adenilson de Souza da; Bernardo-Filho, Mario; Presta, Giuseppe Antonio; Paoli, Severo de; Missailids, Sotiris

2008-01-01

Radiotherapy is a cancer treatment that uses high-energy X-rays or other types of ionizing radiation to try to kill the cancer cells in various organs/tissues. PubMed is a database used as a tool in various publications. The aim of this work was to evaluate, in the PubMed, the number of publications (NP) in radiotherapy and cancer in various organs related to the pelvic floor as well as brachytherapy. The searches were performed (August 2008) in the PubMed (http://www.pubmed.com) using the words: radiotherapy (RT) or cancer (CA), RT and CA, RT and CA and prostate, RT and CA and testis, RT and CA and breast, RT and CA and kidneys, RT and CA and vulva, RT and CA and vagina, RT and CA and penis, RT and CA and uterus, RT and CA and ovary, RT and CA and bladder, and RT and CA and urethra. A search using brachytherapy was also performed. The NP in each subject was determined and was 2178635 to CA and about 9% of them are related with RT. The NP in RT and CA and breast or prostate is bigger than for the other organs, whereas brachytherapy is mainly cited in the studies about CA of prostate, bladder and breast. In conclusion, our findings demonstrate the importance of radiation therapy studies in the cancer of several organs. This information is crucial in understanding the field and demonstrates areas of significant progress or existing gaps of research in radiotherapy treatment of various cancers of the pelvis. Furthermore, it could significantly aid the interprofessional team in the determination of actions related to the treatment of patients that are undertaking radiotherapy, due to the possible complications of this modality of treatment. (author)

Seawater desalination plant using nuclear heating reactor coupled with MED process

Institute of Scientific and Technical Information of China (English)

无

2000-01-01

A small size plant for seawater desalination using nuclear heating reactor coupled with MED process was developed by the Institute of Nuclear Energy Technology, Tsinghua University, China. This seawater desalination plant was designed to supply potable water demand to some coastal location or island where both fresh water and energy source are severely lacking. It is also recommended as a demonstration and training facility for seawater desalination using nuclear energy. The design of small size of seawater desalination plant couples two proven technologies: Nuclear Heating Reactor (NHR) and Multi-Effect Destination (MED) process. The NHR design possesses intrinsic and passive safety features, which was demonstrated by the experiences of the project NHR-5. The intermediate circuit and steam circuit were designed as the safety barriers between the NHR reactor and MED desalination system. Within 10～200 MWt of the power range of the heating reactor, the desalination plant could provide 8000 to 150,000 m3/d of high quality potable water. The design concept and parameters, safety features and coupling scheme are presented.

Seawater desalination plant using nuclear heating reactor coupled with MED process

International Nuclear Information System (INIS)

Wu Shaorong; Dong Duo; Zhang Dafang; Wang Xiuzhen

2000-01-01

A small size plant for seawater desalination using nuclear heating reactor coupled with MED process was developed by the Institute of Nuclear Energy Technology, Tsinghua University, China. this seawater desalination plant was designed to supply potable water demand to some coastal location or island where both fresh water and energy source are severely lacking. It is also recommended as a demonstration and training facility for seawater desalination using nuclear energy. The design of small size of seawater desalination plant couples two proven technologies: Nuclear Heating Reactor (NHR) and Multi-Effect Destination (MED) process. The NHR design possesses intrinsic and passive safety features, which was demonstrated by the experiences of the project NHR-5. the intermediate circuit and steam circuit were designed as the safety barriers between the NHR reactor and MED desalination system. Within 10-200 MWt of the power range of the heating reactor, the desalination plant could provide 8000 to 150,000 m 3 /d of high quality potable water. The design concept and parameters, safety features and coupling scheme are presented

LIVIVO: Neue Herausforderungen an das ZB MED-Suchportal für Lebenswissenschaften

Directory of Open Access Journals (Sweden)

Poley, Christoph

2016-12-01

Full Text Available The German National Library of Medicine (ZB MED has a long track record providing search portals for life sciences. In 2015 LIVIVO was introduced as a new product, which database covers ZB MED’s entire range of subjects: medicine, health, nutrition, environment and agriculture.Initially LIVIVO’s development aimed at realizing a modern search engine combining the functionalities of the predecessor portals. An entirely new web interface was developed, driven by a highly improved usability and a responsive web design. LIVIVO has a great potential in providing search services based on more than 55 million metadata records. Current work of ZB MED focuses on automatic interfaces. Concurrently setting up ZB MED Knowledge Environment creates an indispensable data base for research work at .This article will address the current challenges of a scientific portal using the example of LIVIVO. It will outline the approaches to solutions and development lines.

Does remnant gastric cancer really differ from primary gastric cancer? A systematic review of the literature by the Task Force of Japanese Gastric Cancer Association.

Science.gov (United States)

Shimada, Hideaki; Fukagawa, Takeo; Haga, Yoshio; Oba, Koji

2016-04-01

Remnant gastric cancer, most frequently defined as cancer detected in the remnant stomach after distal gastrectomy for benign disease and those cases after surgery of gastric cancer at least 5 years after the primary surgery, is often reported as a tumor with poor prognosis. The Task Force of Japanese Gastric Cancer Association for Research Promotion evaluated the clinical impact of remnant gastric cancer by systematically reviewing publications focusing on molecular carcinogenesis, lymph node status, patient survival, and surgical complications. A systematic literature search was performed using PubMed/MEDLINE with the keywords "remnant," "stomach," and "cancer," revealing 1154 relevant reports published up to the end of December 2014. The mean interval between the initial surgery and the diagnosis of remnant gastric cancer ranged from 10 to 30 years. The incidence of lymph node metastases at the splenic hilum for remnant gastric cancer is not significantly higher than that for primary proximal gastric cancer. Lymph node involvement in the jejunal mesentery is a phenomenon peculiar to remnant gastric cancer after Billroth II reconstruction. Prognosis and postoperative morbidity and mortality rates seem to be comparable to those for primary proximal gastric cancer. The crude 5-year mortality for remnant gastric cancer was 1.08 times higher than that for primary proximal gastric cancer, but this difference was not statistically significant. In conclusion, although no prospective cohort study has yet evaluated the clinical significance of remnant gastric cancer, our literature review suggests that remnant gastric cancer does not adversely affect patient prognosis and postoperative course.

Hormone Replacement Therapy and Risk of Breast Cancer in Korean Women: A Quantitative Systematic Review

Directory of Open Access Journals (Sweden)

Jong-Myon Bae

2015-09-01

Full Text Available Objectives: The epidemiological characteristics of breast cancer incidence by age group in Korean women are unique. This systematic review aimed to investigate the association between hormone replacement therapy (HRT and breast cancer risk in Korean women. Methods: We searched electronic databases such as KoreaMed, KMbase, KISS, and RISS4U as well as PubMed for publications on Korean breast cancer patients. We also conducted manual searching based on references and citations in potential papers. All of the analytically epidemiologic studies that obtained individual data on HRT exposure and breast cancer occurrence in Korean women were selected. We restricted the inclusion of case-control studies to those that included age-matched controls. Estimates of summary odds ratio (SOR with 95% confidence intervals (CIs were calculated using random effect models. Results: One cohort and five case-control studies were finally selected. Based on the heterogeneity that existed among the six studies (I-squared=70.2%, a random effect model was applied. The summary effect size of HRT history from the six articles indicated no statistical significance in breast cancer risk (SOR, 0.983; 95% CI, 0.620 to 1.556. Conclusions: These facts support no significant effect of HRT history in the risk of breast cancer in Korean women. It is necessary to conduct a pooled analysis.

Childhood cancer and factors related to prolonged diagnostic intervals

DEFF Research Database (Denmark)

Ahrensberg, J M; Olesen, F; Hansen, R P

2013-01-01

overleveringen til hospitalet var af betydning for hvor lang tid, der går fra lægesøgning til diagnose. Metode: Dansk populations-baseret studie. Data for 550 børn cancer diagnose (jan 2007-dec 2010) blev indsamlet vha spørgeskemaer til forældre (response-rate=69%) and praktiserende læger...... barnets symptomer som vage og ukarakteristiske i 25,4%; som alvorlige, men ikke cancer-relaterede i 50,0%; og som alarm symptom i 19,0% af tilfælde. Symptom tolkningen varierede med cancertype (p

Manifest for en psykiatri med brugerrespekt

DEFF Research Database (Denmark)

Samskabelsesprojekt med psykiatribrugere og pårørende. Psykiatri Manifestet består af forskellige statements om psykiatrien som den opleves set fra brugerperspektiv, og visioner om hvor brugerne ønsker, den skal udvikle sig hen. Brugerne har reageret på Marianne Træbing Sechers invitation via hen...... hendes kontoer på Facebook, Twitter og LinkedIn, samt gennem nedenstående facebooksider og interesseorganisationer. Marianne er ansat som adjunkt på VIA University College og står for videreuddannelse, konsulentarbejde og forskning/udvikling på psykiatriområdet i tilknytning hertil....

Leaving the Lecture Behind: Putting PubMed Instruction into the Hands of the Students.

Science.gov (United States)

Turner, Rose L; M Ketchum, Andrea; Ratajeski, Melissa A; Wessel, Charles B

2017-01-01

This column describes the development of a one-shot PubMed instruction class for medical students at a health sciences library. Background information on the objective is presented and discussed in the context of educational practice literature. The new course design centers on a guided group method of instruction in order to integrate more active learning. Surveyed students reported that the method was an effective way to learn how to search PubMed and that they preferred it to a traditional lecture. Pros and cons of the method are offered for other health sciences libraries interested in presenting PubMed instruction in a similar manner.

Musik og billeddannelse (GIM med PTSD-ramte flygtninge: Introduktion til tre single case-studier

Directory of Open Access Journals (Sweden)

Bolette Daniels Beck

2016-12-01

Full Text Available Mange flygtninge kommer fra kulturer med helt andre forestillinger og begreber om årsager til og forventninger om behandling af psykisk lidelse end man almindeligvis anvender i psykiatrien. F.eks. er psykisk lidelse i mange mellemøstlige kulturer forbundet med skam, og udtrykkes måske derfor snarere i form af fysisk smerte. For at et behandlingsforløb skal lykkes, er der behov for kulturel sensitivitet hos behandleren, når der skal samarbejdes med tolken, skabes et møde på tværs af kulturer samt etableres en fælles forståelse af behandlingens formål og proces.

Hva med de gjenstridige dokumentene? Fagreferentrollen i spesialsamlinger

Directory of Open Access Journals (Sweden)

Solveig Greve

2010-07-01

Full Text Available Spesialsamlinger er samlinger av ”gjenstridige dokumenter”, dvs. dokumenter som er sjeldne, unika eller upubliserte og derfor ofte er fysisk bundet til eierinstitusjonen. Det er typisk at slike samlinger mangler moderne standarder for metadata og felles nasjonale katalogiseringsverktøy. Eierinstitusjonene har et kulturansvar for bevaring og tilgjengeliggjøring av disse dokumentene overfor en bredere allmennhet enn et fagbiblioteks ”primærbrukere”. Fagreferentens oppgaver vil være preget av dette. Bevaring, sikring og produksjon av digitale fulltekstdokumenter er sentralt. Det er også typisk for slike samlinger at en har en betydelig backlog. Det vil være fagreferentens oppgave å løfte fram ukjent kildemateriale, gjennom digitaliseringsprosjekter og forskning. Fagreferentens viktigste oppgaver vil da være mer rettet mot samlingspleie og formidling av egne samlinger og mindre fokus på andre institusjoners samlinger. Slik vil også undervisningen av studentene bli preget av arkivpresntasjon av innhold og forelesninger om teoretiske og praktiske forhold knyttet til å arbeide med spesielle materialtyper og mindre til utvikling av vanlig informasjonskompetanse. Denne situasjonen vil forandre seg hvis/når institusjonene blir enige om utvekslingsformater og mengden av digitale fulltekstdokumenter øker. Utfordringene for spesialsamlinger vil også være fagreferentenes utfordringer; I en stadig mer elektronisk verden, kan arbeidet med de fysiske samlingene lett bli marginalisert, selv om nettopp den tekniske utviklingen kunne løse mange problemer for de gjenstridige dokumentene. Men slik prioritering krever store ressurser, høy kompetanse, engasjement og politisk gjennomslagskraft. Kostnadene er høye, og konkurrerer budsjettmessig med galopperende elektroniske utgifter for hele biblioteket. Spesialsamlingenes fagreferenter kan bli en minoritetsstemme i bibliotekenes moderniseringsprosess, til skade for bibliotekenes totale faglige

Impact of PubMed search filters on the retrieval of evidence by physicians.

Science.gov (United States)

Shariff, Salimah Z; Sontrop, Jessica M; Haynes, R Brian; Iansavichus, Arthur V; McKibbon, K Ann; Wilczynski, Nancy L; Weir, Matthew A; Speechley, Mark R; Thind, Amardeep; Garg, Amit X

2012-02-21

Physicians face challenges when searching PubMed for research evidence, and they may miss relevant articles while retrieving too many nonrelevant articles. We investigated whether the use of search filters in PubMed improves searching by physicians. We asked a random sample of Canadian nephrologists to answer unique clinical questions derived from 100 systematic reviews of renal therapy. Physicians provided the search terms that they would type into PubMed to locate articles to answer these questions. We entered the physician-provided search terms into PubMed and applied two types of search filters alone or in combination: a methods-based filter designed to identify high-quality studies about treatment (clinical queries "therapy") and a topic-based filter designed to identify studies with renal content. We evaluated the comprehensiveness (proportion of relevant articles found) and efficiency (ratio of relevant to nonrelevant articles) of the filtered and nonfiltered searches. Primary studies included in the systematic reviews served as the reference standard for relevant articles. The average physician-provided search terms retrieved 46% of the relevant articles, while 6% of the retrieved articles were relevant (corrected) (the ratio of relevant to nonrelevant articles was 1:16). The use of both filters together produced a marked improvement in efficiency, resulting in a ratio of relevant to nonrelevant articles of 1:5 (16 percentage point improvement; 99% confidence interval 9% to 22%; p PubMed search filters improves the efficiency of physician searches. Improved search performance may enhance the transfer of research into practice and improve patient care.

Ledelsesretten - hvad skal vi stille op med den?

DEFF Research Database (Denmark)

Pagh, Lone

2016-01-01

for ledelsesretten at træde ind som en kommunikerbar og legitim rammesætning i lederens praksis. Artiklen inddrager i sin analyse retssociologiske perspektiver i et moderne og postmoderne perspektiv og rundes af med en diskussion af de faldgruber, det kan indebære, når ledelsesrettens styringssprog skal omsættes til...

Supplementary searches of PubMed to improve currency of MEDLINE and MEDLINE In-Process searches via Ovid.

Science.gov (United States)

Duffy, Steven; de Kock, Shelley; Misso, Kate; Noake, Caro; Ross, Janine; Stirk, Lisa

2016-10-01

The research investigated whether conducting a supplementary search of PubMed in addition to the main MEDLINE (Ovid) search for a systematic review is worthwhile and to ascertain whether this PubMed search can be conducted quickly and if it retrieves unique, recently published, and ahead-of-print studies that are subsequently considered for inclusion in the final systematic review. Searches of PubMed were conducted after MEDLINE (Ovid) and MEDLINE In-Process (Ovid) searches had been completed for seven recent reviews. The searches were limited to records not in MEDLINE or MEDLINE In-Process (Ovid). Additional unique records were identified for all of the investigated reviews. Search strategies were adapted quickly to run in PubMed, and reviewer screening of the results was not time consuming. For each of the investigated reviews, studies were ordered for full screening; in six cases, studies retrieved from the supplementary PubMed searches were included in the final systematic review. Supplementary searching of PubMed for studies unavailable elsewhere is worthwhile and improves the currency of the systematic reviews.

Læringslandskaber for elever med indlæringsvanskeligheder

DEFF Research Database (Denmark)

Szulevicz, Thomas

Baggrund Denne afhandling består af en empirisk undersøgelse af den pædagogiske praksis på Havredal Praktiske Landbrugsskole (HPL). HPL er en mesterlæreinspireret landbrugsuddannelse for unge elever mellem 16-25 år med indlæringsvanskeligheder. HPL fungerer som et moderne landbrug, der drives af...... elever og lærere i fællesskab. Der er 38 indskrevne elever på skolen, der dyrker 140 ha jord og har en besætning på 50 sortbrogede malkekøer i løsdriftsstald, 250 søer samt 10 heste. Elevernes uddannelse og læring er struktureret omkring deres deltagelse i landbrugsaktiviteterne på skolen. HPL er...... observationerne fandt sted i forskningsprojektets første 14 måneder. Herudover er der blevet foretaget kvalitative interviews med 12 elever fra HPL. Heraf blev de 7 af eleverne interviewet à 3 omgange. 7 lærere på HPL er blevet interviewet. Endelig er der blevet foretaget to videoobservationer af en elevs...

14 medisinplanter fra Burma med fokus på lakserende effekt : en litteraturstudie

OpenAIRE

Phan, Cong Lap

2009-01-01

I denne masteroppgaven ble det sett på sammenhenger mellom vitenskapelige data som er tilgjengelige og bruken av 14 tradisjonelle medisinplanter, med fokus på lakserende effekt. Plantene er hentet fra Burma-samlingen som ble laget av Arnold Nordal i 1957-1961. Det ble først og fremst foretatt litteratursøk i databasene Scifinder Scholar 2007, Biological Abstract, ISI Web of Knowledge- Web of Science og PubMed. Søk på synonymnavn ble foretatt i plantedatabasene IPNI, ITIS og Tropicos....

Quince años de MedUNAB

Directory of Open Access Journals (Sweden)

Natalia Hérnandez Rey

2013-08-01

Full Text Available Para conmemorar los quince años de MedUNAB el comité estudiantil quiso escribir sobre el significado que tiene para cada uno de sus miembros pertenecer a ella. Es así como en este editorial recogemos las distintas experiencias que se han tenido, algunas de años, otras de meses. MedUNAB es una escuela editorial que hace posible que tres veces al año la comunidad académica de Latinoamérica cuente, tanto física como virtualmente, con una revista científica del área de la salud. Los miembros del comité estudiantil son seleccionados por el editor y por los integrantes con más antigüedad después de hacer un entrenamiento en el cual se aprenden las bases para el proceso editorial que va desde la recepción de los artículos, hasta cómo hacer llegar la revista a cada uno de ustedes en aulas de clase, congresos, simposios, charlas y consultorios, pasando por la evaluación de los escritos, basada en los estrictos parámetros internacionales, la búsqueda de revisores calificados, la corrección de estilo y la diagramación.

Mediator subunit MED1 is a T3-dependent and T3-independent coactivator on the thyrotropin β gene promoter

Energy Technology Data Exchange (ETDEWEB)

Matsui, Keiji; Oda, Kasumi; Mizuta, Shumpei; Ishino, Ruri; Urahama, Norinaga; Hasegawa, Natsumi [Laboratory of Hematology, Division of Medical Biophysics, Kobe University Graduate School of Health Sciences, 7-10-2 Tomogaoka, Suma-ku, Kobe 654-0142 (Japan); Roeder, Robert G. [Laboratory of Biochemistry and Molecular Biology, The Rockefeller University, 1230 York Avenue, New York, NY 10065 (United States); Ito, Mitsuhiro, E-mail: itomi@med.kobe-u.ac.jp [Laboratory of Hematology, Division of Medical Biophysics, Kobe University Graduate School of Health Sciences, 7-10-2 Tomogaoka, Suma-ku, Kobe 654-0142 (Japan); Laboratory of Biochemistry and Molecular Biology, The Rockefeller University, 1230 York Avenue, New York, NY 10065 (United States); Department of Family and Community Medicine, Kobe University Graduate School of Medicine, 7-5-1 Kusunoki-cho, Chuo-ku, Kobe 654-0142 (Japan); Consolidated Research Institute for Advanced Science and Medical Care, Waseda University, 3-4-1 Okubo, Shinjuku-ku, Tokyo 159-8555 (Japan)

2013-10-11

Highlights: •MED1 is a bona fide T3-dependent coactivator on TSHB promoter. •Mice with LxxLL-mutant MED1 have attenuated TSHβ mRNA and thyroid hormone levels. •MED1 activates TSHB promoter T3-dependently in cultured cells. •T3-dependent MED1 action is enhanced when SRC1/SRC2 or HDAC2 is downregulated. •MED1 is also a T3-independent GATA2/Pit1 coactivator on TSHB promoter. -- Abstract: The MED1 subunit of the Mediator transcriptional coregulator complex is a nuclear receptor-specific coactivator. A negative feedback mechanism of thyroid-stimulating hormone (TSH, or thyrotropin) expression in the thyrotroph in the presence of triiodothyronine (T3) is employed by liganded thyroid hormone receptor β (TRβ) on the TSHβ gene promoter, where conventional histone-modifying coactivators act as corepressors. We now provide evidence that MED1 is a ligand-dependent positive cofactor on this promoter. TSHβ gene transcription was attenuated in MED1 mutant mice in which the nuclear receptor-binding ability of MED1 was specifically disrupted. MED1 stimulated GATA2- and Pit1-mediated TSHβ gene promoter activity in a ligand-independent manner in cultured cells. MED1 also stimulated transcription from the TSHβ gene promoter in a T3-dependent manner. The transcription was further enhanced when the T3-dependent corepressors SRC1, SRC2, and HDAC2 were downregulated. Hence, MED1 is a T3-dependent and -independent coactivator on the TSHβ gene promoter.

Udvikling af dialogisk kompetence hos børn med CI

DEFF Research Database (Denmark)

Dammeyer, Jesper Herup; Carstensen, Susanne; Karlshøj, Bente

2011-01-01

Der er relativ god viden om børn med CI’s sproglige udvikling, hvad angår sproglyde og ord. Derimod er der i den internationale forskning kun beskrevet meget lidt om den del af den sproglige udvikling, som ligger ud over sætningsniveauet. Denne artikel beskriver nogle af de resultater, der er...... fremkommet ved et fire år langt følgestudie af tre førskolebørn med CI. Børnenes sproglige udvikling er observeret og analyseret i forhold til dialogiske kompetencer. Resultaterne peger på, at børnene udvikler gode talesproglige kompetencer i løbet af den fireårige periode, men at børnene har brug for støtte...

Papillae formation on trichome cell walls requires the function of the mediator complex subunit Med25.

Science.gov (United States)

Fornero, Christy; Suo, Bangxia; Zahde, Mais; Juveland, Katelyn; Kirik, Viktor

2017-11-01

Glassy Hair 1 (GLH1) gene that promotes papillae formation on trichome cell walls was identified as a subunit of the transcriptional mediator complex MED25. The MED25 gene is shown to be expressed in trichomes. The expression of the trichome development marker genes GLABRA2 (GL2) and Ethylene Receptor2 (ETR2) is not affected in the glh1 mutant. Presented data suggest that Arabidopsis MED25 mediator component is likely involved in the transcription of genes promoting papillae deposition in trichomes. The plant cell wall plays an important role in communication, defense, organization and support. The importance of each of these functions varies by cell type. Specialized cells, such as Arabidopsis trichomes, exhibit distinct cell wall characteristics including papillae. To better understand the molecular processes important for papillae deposition on the cell wall surface, we identified the GLASSY HAIR 1 (GLH1) gene, which is necessary for papillae formation. We found that a splice-site mutation in the component of the transcriptional mediator complex MED25 gene is responsible for the near papillae-less phenotype of the glh1 mutant. The MED25 gene is expressed in trichomes. Reporters for trichome developmental marker genes GLABRA2 (GL2) and Ethylene Receptor2 (ETR2) were not affected in the glh1 mutant. Collectively, the presented results show that MED25 is necessary for papillae formation on the cell wall surface of leaf trichomes and suggest that the Arabidopsis MED25 mediator component is likely involved in the transcription of a subset of genes that promote papillae deposition in trichomes.

PMD2HD--a web tool aligning a PubMed search results page with the local German Cancer Research Centre library collection.

Science.gov (United States)

Bohne-Lang, Andreas; Lang, Elke; Taube, Anke

2005-06-27

Web-based searching is the accepted contemporary mode of retrieving relevant literature, and retrieving as many full text articles as possible is a typical prerequisite for research success. In most cases only a proportion of references will be directly accessible as digital reprints through displayed links. A large number of references, however, have to be verified in library catalogues and, depending on their availability, are accessible as print holdings or by interlibrary loan request. The problem of verifying local print holdings from an initial retrieval set of citations can be solved using Z39.50, an ANSI protocol for interactively querying library information systems. Numerous systems include Z39.50 interfaces and therefore can process Z39.50 interactive requests. However, the programmed query interaction command structure is non-intuitive and inaccessible to the average biomedical researcher. For the typical user, it is necessary to implement the protocol within a tool that hides and handles Z39.50 syntax, presenting a comfortable user interface. PMD2HD is a web tool implementing Z39.50 to provide an appropriately functional and usable interface to integrate into the typical workflow that follows an initial PubMed literature search, providing users with an immediate asset to assist in the most tedious step in literature retrieval, checking for subscription holdings against a local online catalogue. PMD2HD can facilitate literature access considerably with respect to the time and cost of manual comparisons of search results with local catalogue holdings. The example presented in this article is related to the library system and collections of the German Cancer Research Centre. However, the PMD2HD software architecture and use of common Z39.50 protocol commands allow for transfer to a broad range of scientific libraries using Z39.50-compatible library information systems.

Cancer survivorship: history, quality-of-life issues, and the evolving multidisciplinary approach to implementation of cancer survivorship care plans.

Science.gov (United States)

Morgan, Mary Ann

2009-07-01

To discuss the history of cancer survivorship, related quality-of-life issues, and cancer survivorship care plans (CSCPs). CINAHL, PubMed, published articles, and Web sites. A cancer survivor is an individual who has been diagnosed with cancer, regardless of when that diagnosis was received, who is still living. Cancer survivorship is complex and involves many aspects of care. Major areas of concern for survivors are recurrence, secondary malignancies, and long-term treatment sequelae that affect quality of life. Four essential components of survivorship care are prevention, surveillance, intervention, and coordination. A CSCP should address the survivor's long-term care, such as type of cancer, treatments received, potential side effects, and recommendations for follow-up. It should include preventive practices, how to maintain health and well-being, information on legal protections regarding employment and health insurance, and psychosocial services in the community. Survivorship care for patients with cancer requires a multidisciplinary effort and team approach. Enhanced knowledge of long-term complications of survivorship is needed for healthcare providers. Further research on evidence-based practice for cancer survivorship care also is necessary. Nurses can review CSCPs with patients, instruct them when to seek treatment, promote recommended surveillance protocols, and encourage behaviors that lead to cancer prevention and promote well-being for cancer survivors.

The Role of Tumor Metastases Suppressor Gene, Drg-1, in Breast Cancer

Science.gov (United States)

2008-03-01

evidence to validate 14 our data of breast cancer. However, these prostate cells and reagents were existing materials in our lab or purchased by using...J. Lab . Clin. Med. 133, 265–273. Sloane, B.F., Honn, K.V., 1984. Cysteine proteinases and metastasis. Cancer Metastasis Rev. 3, 249–263. Sridhar, S.C... Beest , P. Moerer, K. van der Horn, R. Goldschmeding, T. Logtenberg and H. Clevers: Synergy between tumor suppressor APC and the beta- catenin-Tcf4

Hypertension in Patients with Cancer

Energy Technology Data Exchange (ETDEWEB)

Souza, Vinicius Barbosa de; Silva, Eduardo Nani; Ribeiro, Mario Luiz; Martins, Wolney de Andrade, E-mail: wolney@cardiol.br [Curso de Pós-Graduação em Ciências Cardiovasculares da Universidade Federal Fluminense, Niterói, RJ (Brazil)

2015-03-15

There is a known association between chemotherapy and radiotherapy for treatment of cancer patients and development or worsening of hypertension. The aim of this article is to review this association. A literature search was conducted for articles reporting this association on the databases PubMed, SciELO and LILACS between 1993 and 2013. There was a high coprevalence of hypertension and cancer, since both diseases share the same risk factors, such as sedentary lifestyle, obesity, smoking, unhealthy diet and alcohol abuse. The use of chemotherapy and adjuvant drugs effective in the treatment of cancer increased the survival rate of these patients and, consequently, increased the incidence of hypertension. We described the association between the use of angiogenesis inhibitors (bevacizumab, sorafenib and sunitinib), corticosteroids, erythropoietin and non-steroidal anti-inflammatory drugs with the development of hypertension. We also described the relationship between hypertension and carotid baroreceptor injury secondary to cervical radiotherapy. Morbidity and mortality increased in patients with cancer and hypertension without proper antihypertensive treatment. We concluded that there is need for early diagnosis, effective monitoring and treatment strategies for hypertension in cancer patients in order to reduce cardiovascular morbidity and mortality.

Hypertension in Patients with Cancer

International Nuclear Information System (INIS)

Souza, Vinicius Barbosa de; Silva, Eduardo Nani; Ribeiro, Mario Luiz; Martins, Wolney de Andrade

2015-01-01

There is a known association between chemotherapy and radiotherapy for treatment of cancer patients and development or worsening of hypertension. The aim of this article is to review this association. A literature search was conducted for articles reporting this association on the databases PubMed, SciELO and LILACS between 1993 and 2013. There was a high coprevalence of hypertension and cancer, since both diseases share the same risk factors, such as sedentary lifestyle, obesity, smoking, unhealthy diet and alcohol abuse. The use of chemotherapy and adjuvant drugs effective in the treatment of cancer increased the survival rate of these patients and, consequently, increased the incidence of hypertension. We described the association between the use of angiogenesis inhibitors (bevacizumab, sorafenib and sunitinib), corticosteroids, erythropoietin and non-steroidal anti-inflammatory drugs with the development of hypertension. We also described the relationship between hypertension and carotid baroreceptor injury secondary to cervical radiotherapy. Morbidity and mortality increased in patients with cancer and hypertension without proper antihypertensive treatment. We concluded that there is need for early diagnosis, effective monitoring and treatment strategies for hypertension in cancer patients in order to reduce cardiovascular morbidity and mortality

#GeriMedJC: The Twitter Complement to the Traditional-Format Geriatric Medicine Journal Club.

Science.gov (United States)

Gardhouse, Amanda I; Budd, Laura; Yang, Seu Y C; Wong, Camilla L

2017-06-01

Twitter is a public microblogging platform that overcomes physical limitations and allows unrestricted participation beyond academic silos, enabling interactive discussions. Twitter-based journal clubs have demonstrated growth, sustainability, and worldwide communication, using a hashtag (#) to follow participation. This article describes the first year of #GeriMedJC, a monthly 1-hour live, 23-hour asynchronous Twitter-based complement to the traditional-format geriatric medicine journal club. The Twitter moderator tweets from the handle @GeriMedJC; encourages use of #GeriMedJC; and invites content experts, study authors, and followers to participate in critical appraisal of medical literature. Using the hashtag #GeriMedJC, tweets were categorized according to thematic content, relevance to the journal club, and authorship. Third-party analytical tools Symplur and Twitter Analytics were used for growth and effect metrics (number of followers, participants, tweets, retweets, replies, impressions). Qualitative analysis of follower and participant profiles was used to establish country of origin and occupation. A semistructured interview of postgraduate trainees was conducted to ascertain qualitative aspects of the experience. In the first year, @GeriMedJC has grown to 541 followers on six continents. Most followers were physicians (43%), two-thirds of which were geriatricians. Growth metrics increased over 12 months, with a mean of 121 tweets, 25 participants, and 105,831 impressions per journal club. Tweets were most often related to the article being appraised (87.5%) and ranged in thematic content from clinical practice (29%) to critical appraisal (24%) to medical education (20%). #GeriMedJC is a feasible example of using social media platforms such as Twitter to encourage international and interprofessional appraisal of medical literature. © 2017, Copyright the Authors Journal compilation © 2017, The American Geriatrics Society.

MedMon: securing medical devices through wireless monitoring and anomaly detection.

Science.gov (United States)

Zhang, Meng; Raghunathan, Anand; Jha, Niraj K

2013-12-01

Rapid advances in personal healthcare systems based on implantable and wearable medical devices promise to greatly improve the quality of diagnosis and treatment for a range of medical conditions. However, the increasing programmability and wireless connectivity of medical devices also open up opportunities for malicious attackers. Unfortunately, implantable/wearable medical devices come with extreme size and power constraints, and unique usage models, making it infeasible to simply borrow conventional security solutions such as cryptography. We propose a general framework for securing medical devices based on wireless channel monitoring and anomaly detection. Our proposal is based on a medical security monitor (MedMon) that snoops on all the radio-frequency wireless communications to/from medical devices and uses multi-layered anomaly detection to identify potentially malicious transactions. Upon detection of a malicious transaction, MedMon takes appropriate response actions, which could range from passive (notifying the user) to active (jamming the packets so that they do not reach the medical device). A key benefit of MedMon is that it is applicable to existing medical devices that are in use by patients, with no hardware or software modifications to them. Consequently, it also leads to zero power overheads on these devices. We demonstrate the feasibility of our proposal by developing a prototype implementation for an insulin delivery system using off-the-shelf components (USRP software-defined radio). We evaluate its effectiveness under several attack scenarios. Our results show that MedMon can detect virtually all naive attacks and a large fraction of more sophisticated attacks, suggesting that it is an effective approach to enhancing the security of medical devices.

Medical literature searches: a comparison of PubMed and Google Scholar.

Science.gov (United States)

Nourbakhsh, Eva; Nugent, Rebecca; Wang, Helen; Cevik, Cihan; Nugent, Kenneth

2012-09-01

Medical literature searches provide critical information for clinicians. However, the best strategy for identifying relevant high-quality literature is unknown. We compared search results using PubMed and Google Scholar on four clinical questions and analysed these results with respect to article relevance and quality. Abstracts from the first 20 citations for each search were classified into three relevance categories. We used the weighted kappa statistic to analyse reviewer agreement and nonparametric rank tests to compare the number of citations for each article and the corresponding journals' impact factors. Reviewers ranked 67.6% of PubMed articles and 80% of Google Scholar articles as at least possibly relevant (P = 0.116) with high agreement (all kappa P-values PubMed searches and Google Scholar searches often identify different articles. In this study, Google Scholar articles were more likely to be classified as relevant, had higher numbers of citations and were published in higher impact factor journals. The identification of frequently cited articles using Google Scholar for searches probably has value for initial literature searches. © 2012 The authors. Health Information and Libraries Journal © 2012 Health Libraries Group.

Dialysis search filters for PubMed, Ovid MEDLINE, and Embase databases.

Science.gov (United States)

Iansavichus, Arthur V; Haynes, R Brian; Lee, Christopher W C; Wilczynski, Nancy L; McKibbon, Ann; Shariff, Salimah Z; Blake, Peter G; Lindsay, Robert M; Garg, Amit X

2012-10-01

Physicians frequently search bibliographic databases, such as MEDLINE via PubMed, for best evidence for patient care. The objective of this study was to develop and test search filters to help physicians efficiently retrieve literature related to dialysis (hemodialysis or peritoneal dialysis) from all other articles indexed in PubMed, Ovid MEDLINE, and Embase. A diagnostic test assessment framework was used to develop and test robust dialysis filters. The reference standard was a manual review of the full texts of 22,992 articles from 39 journals to determine whether each article contained dialysis information. Next, 1,623,728 unique search filters were developed, and their ability to retrieve relevant articles was evaluated. The high-performance dialysis filters consisted of up to 65 search terms in combination. These terms included the words "dialy" (truncated), "uremic," "catheters," and "renal transplant wait list." These filters reached peak sensitivities of 98.6% and specificities of 98.5%. The filters' performance remained robust in an independent validation subset of articles. These empirically derived and validated high-performance search filters should enable physicians to effectively retrieve dialysis information from PubMed, Ovid MEDLINE, and Embase.

Danske og svenske forbrugeres syn på e-handel med dagligvarer

DEFF Research Database (Denmark)

Kornum, Niels

2003-01-01

, at det er vigtigt at få forbrugerne til at prøve ordningerne f.eks. viatilbud og/eller forskellige medlemsfordele for at motivere dem til at indgå i ordningen. Detviser to nye undersøgelser gennemført af forskere fra Institut for Afsætningsøkonomi,Handelshøjskolen i København i samarbejde med forskere......,dels at de bliver mindre afhængige af butikkernes åbningstider. De vigtigste ulemper set fraforbrugerside er dels at online handel er mindre spændende end køb i supermarkedet, delsat der er begrænset adgang til at se og føle på varerne før køb i online butikken. Det er dogforbrugere, der ikke har handlet på...... deresdagligvareindkøb online. En medvirkende årsag kan dog desuden være, at mangeforbrugere ikke har tilstrækkeligt med informationer til at kunne skønne omfanget af deomkostninger, som må bæres af online leverandøren i forbindelse med pakning,distribution mv. af dagligvarerne.Undersøgelsen viser, at et klart og...

TeleMed: Wide-area, secure, collaborative object computing with Java and CORBA for healthcare

Energy Technology Data Exchange (ETDEWEB)

Forslund, D.W.; George, J.E.; Gavrilov, E.M.

1998-12-31

Distributed computing is becoming commonplace in a variety of industries with healthcare being a particularly important one for society. The authors describe the development and deployment of TeleMed in a few healthcare domains. TeleMed is a 100% Java distributed application build on CORBA and OMG standards enabling the collaboration on the treatment of chronically ill patients in a secure manner over the Internet. These standards enable other systems to work interoperably with TeleMed and provide transparent access to high performance distributed computing to the healthcare domain. The goal of wide scale integration of electronic medical records is a grand-challenge scale problem of global proportions with far-reaching social benefits.

Breast Cancer, Aromatase Inhibitor Therapy, and Sexual Functioning: A Pilot Study of the Effects of Vaginal Testosterone Therapy

Directory of Open Access Journals (Sweden)

Melissa Dahir, DNP, IF

2014-04-01

Conclusions: The use of a compounded testosterone vaginal cream applied daily for 4 weeks improves reported sexual health quality of life in women with breast cancer taking AIs. Dahir M and Travers‐Gustafson D. Breast cancer, aromatase inhibitor therapy, and sexual functioning: A pilot study of the effects of vaginal testosterone therapy. Sex Med 2014;2:8–15.

En integrativ terapeutisk anvendelse af sang med udgangspunkt i neuropsykologiske, psykofysiologiske og psykodynamiske teorier

DEFF Research Database (Denmark)

Ridder, Hanne Mette Ochsner

2007-01-01

Hvordan kan terapeutiske forløb tilrettelægges så klienter med svære neurologiske forstyrrelser, fx mennesker med en demenssygdom, kan opnå en form for indsigt og terapeutisk forandring? Dette spørgsmål søges besvaret ved at beskrive anvendelsen af sang i den terapeutiske relation ud fra neuropsy...

GenderMedDB: an interactive database of sex and gender-specific medical literature.

Science.gov (United States)

Oertelt-Prigione, Sabine; Gohlke, Björn-Oliver; Dunkel, Mathias; Preissner, Robert; Regitz-Zagrosek, Vera

2014-01-01

Searches for sex and gender-specific publications are complicated by the absence of a specific algorithm within search engines and by the lack of adequate archives to collect the retrieved results. We previously addressed this issue by initiating the first systematic archive of medical literature containing sex and/or gender-specific analyses. This initial collection has now been greatly enlarged and re-organized as a free user-friendly database with multiple functions: GenderMedDB (http://gendermeddb.charite.de). GenderMedDB retrieves the included publications from the PubMed database. Manuscripts containing sex and/or gender-specific analysis are continuously screened and the relevant findings organized systematically into disciplines and diseases. Publications are furthermore classified by research type, subject and participant numbers. More than 11,000 abstracts are currently included in the database, after screening more than 40,000 publications. The main functions of the database include searches by publication data or content analysis based on pre-defined classifications. In addition, registrants are enabled to upload relevant publications, access descriptive publication statistics and interact in an open user forum. Overall, GenderMedDB offers the advantages of a discipline-specific search engine as well as the functions of a participative tool for the gender medicine community.

Carcinoembryonic antigen (CEA) as tumor marker in lung cancer

DEFF Research Database (Denmark)

Knudsen, Mie Grunnet; Sorensen, J B

2012-01-01

The use of CEA as a prognostic and predictive marker in patients with lung cancer is widely debated. The aim of this review was to evaluate the results from studies made on this subject. Using the search words "CEA", "tumor markers in lung cancer", "prognostic significance", "diagnostic...... significance" and "predictive significance", a search was carried out on PubMed. Exclusion criteria was articles never published in English, articles before 1981 and articles evaluating tumor markers in lung cancer not involving CEA. Initially 217 articles were found, and 34 were left after selecting those...... relevant for the present study. Four of these included both Non-Small Cell Lung Cancer (NSCLC) and Small Cell Lung Cancer (SCLC) patients, and 31 dealt solely with NSCLC patients. Regarding SCLC no studies showed that serum level of CEA was a prognostic marker for overall survival (OS). The use of CEA...

Older cancer patients in cancer clinical trials are underrepresented. Systematic literature review of almost 5000 meta- and pooled analyses of phase III randomized trials of survival from breast, prostate and lung cancer.

Science.gov (United States)

Dunn, Cita; Wilson, Andrew; Sitas, Freddy

2017-12-01

Older people represent increasing proportions of the population with cancer. To understand the representivity of cancer treatments in older people, we performed a systematic literature review using PRISMA guidelines of the age distribution of clinical trial participants for three leading cancer types, namely breast, prostate, and lung. We used PubMed to identify articles detailing meta or pooled-analyses of phase III, randomised controlled trials (RCTs) of survival for breast, prostate and lung cancer, published ≤5 years from 2016. We compared the age distribution of participants to that of these cancers for "More developed regions". 4993 potential papers were identified, but only three papers on breast cancer, three on lung cancer, and none on prostate cancer presented the age distribution of their participants. Except for one paper of breast cancer, participants ≥70 years in all other papers were underrepresented. We recommend the age distribution of patients be clearly reported in all clinical trials, as per guidelines. Clinical trials ought to be more representative of the populations most affected by the disease for which treatments are being tested. This should lead to better knowledge of effectiveness of treatments and better translation of trial results to optimal care of older cancer patients. Copyright © 2017 Elsevier Ltd. All rights reserved.

PubMed vs. HighWire Press: a head-to-head comparison of two medical literature search engines.

Science.gov (United States)

Vanhecke, Thomas E; Barnes, Michael A; Zimmerman, Janet; Shoichet, Sandor

2007-09-01

PubMed and HighWire Press are both useful medical literature search engines available for free to anyone on the internet. We measured retrieval accuracy, number of results generated, retrieval speed, features and search tools on HighWire Press and PubMed using the quick search features of each. We found that using HighWire Press resulted in a higher likelihood of retrieving the desired article and higher number of search results than the same search on PubMed. PubMed was faster than HighWire Press in delivering search results regardless of search settings. There are considerable differences in search features between these two search engines.

Der er faresignaler her - om ret og heuristik i det almindelige, kommunale tilsyn med børn og unge

DEFF Research Database (Denmark)

Svendsen, Idamarie Leth

2014-01-01

KORT RESUME Kommunerne underlægges i stigende grad krav om at føre et aktivt og opsøgende tilsyn med børn og unge. Kravene fremgår af serviceloven med tilhørende forskrifter. Disse regler har sammenhæng med en række andre regler på det sociale og velfærdsretlige område i øvrigt, men også med forv...

Male Breast Cancer as a Second Primary Cancer: Increased Risk Following Lymphoma.

Science.gov (United States)

Farr, Deborah E; Thomas, Alexandra; Khan, Seema Ahsan; Schroeder, Mary C

2017-08-01

Male breast cancer (MBC) as a second primary cancer (SPC) has a known association with prior MBC. However, its association with non-breast index malignancies, relative to population risk, has not been previously reported. Using Surveillance, Epidemiology, and End Results program (9 catchment area) data, we identified MBCs diagnosed from 1973-2012 as their SPC. Information regarding the index malignancy was also obtained. Standardized incidence ratios (SIR) of MBC as SPC were estimated, along with incidence rates and trends. Kaplan-Meier curves were used to estimate survival. Over a 38-year period, 464 MBCs were identified as SPC. The most common index malignancies were breast (SIR 30.86, 95% confidence interval [CI] 21.50-42.92, p  Male breast cancer as a SPC has increased markedly over 4 decades. Men with a history of lymphoma may experience higher-than-expected rates of breast SPC. These observations warrant further research, and suggest possible etiologic connections with disease biology, prior therapy, or genetics. This study reports that men are presenting more frequently to the clinic with breast cancer, both as an initial cancer and as a second cancer following an earlier malignancy. We also report the novel observation that men who survive lymphoma are at increased risk of developing a subsequent breast cancer. Further work is needed to better understand possible treatment or biologic causes of this association. More immediately, these findings suggest the need for heightened vigilance for male breast cancer overall and, in particular, for male lymphoma survivors. © AlphaMed Press 2017.

1 Driftsøkonomi med planlegging 2 Wild reindeer of the Soviet Union

Directory of Open Access Journals (Sweden)

Sven Skjenneberg

1985-05-01

Full Text Available Ansgar J. Kosmo. 1986. "Driftsøkonomi med planlegging". Reindriftsadministrasjonen, Alta. 111s. (Foreligger i januaer 1986. Utgis i samarbeid med Samisk utdanningsråd.E.E. Syroechovskij (ed.. 1984. "Wild reindeer of the Soviet Union". English version by U.S. Department of Interior and National Science Foundation. Lectures presented at a research conference at Dudinka, Taimyr in 1975. 43 lectures , some also with direct importance for the reindeer husbandry.

Kvalitetscirkler – at arbejde med kvalitet uden at gå i stå

DEFF Research Database (Denmark)

Pedersen, Ulla

2001-01-01

Artiklen omhandler en metode, kvalitetscirkler, til kvalitetssikring og -udvikling. Metoden er udsprunget fra Demings teori og anvendes til bottom-up udvikling. Den er afprøvet i pilotprojekt i ergoterapien på Sønderborg Sygehus med succes.......Artiklen omhandler en metode, kvalitetscirkler, til kvalitetssikring og -udvikling. Metoden er udsprunget fra Demings teori og anvendes til bottom-up udvikling. Den er afprøvet i pilotprojekt i ergoterapien på Sønderborg Sygehus med succes....

Aktivistisk med forbehold? Danmark, EU og den amerikanske verdensorden

DEFF Research Database (Denmark)

Wivel, Anders

2017-01-01

I hvilken grad og hvordan kan dansk europapolitik tolkes som aktivistisk? Dansk europapolitik er karakteriseret ved stor kontinuitet med en kombination af pragmatisk interessevaretagelse og forsøg på dagsordensættende indflydelsesmaksimering på udvalgte værdipolitiske områder. Samtidig er europap...

MED23-associated intellectual disability in a non-consanguineous family.

Science.gov (United States)

Trehan, Aditi; Brady, Jacqueline M; Maduro, Valerie; Bone, William P; Huang, Yan; Golas, Gretchen A; Kane, Megan S; Lee, Paul R; Thurm, Audrey; Gropman, Andrea L; Paul, Scott M; Vezina, Gilbert; Markello, Thomas C; Gahl, William A; Boerkoel, Cornelius F; Tifft, Cynthia J

2015-06-01

Intellectual disability (ID) is a heterogeneous condition arising from a variety of environmental and genetic factors. Among these causes are defects in transcriptional regulators. Herein, we report on two brothers in a nonconsanguineous family with novel compound heterozygous, disease-segregating mutations (NM_015979.3: [3656A > G];[4006C > T], NP_057063.2: [H1219R];[R1336X]) in MED23. This gene encodes a subunit of the Mediator complex that modulates the expression of RNA polymerase II-dependent genes. These brothers, who had profound ID, spasticity, congenital heart disease, brain abnormalities, and atypical electroencephalography, represent the first case of MED23-associated ID in a non-consanguineous family. They also expand upon the clinical features previously reported for mutations in this gene. © 2015 Wiley Periodicals, Inc.

The Mediator Complex MED15 Subunit Mediates Activation of Downstream Lipid-Related Genes by the WRINKLED1 Transcription Factor.

Science.gov (United States)

Kim, Mi Jung; Jang, In-Cheol; Chua, Nam-Hai

2016-07-01

The Mediator complex is known to be a master coordinator of transcription by RNA polymerase II, and this complex is recruited by transcription factors (TFs) to target promoters for gene activation or repression. The plant-specific TF WRINKLED1 (WRI1) activates glycolysis-related and fatty acid biosynthetic genes during embryogenesis. However, no Mediator subunit has yet been identified that mediates WRI1 transcriptional activity. Promoter-β-glucuronidase fusion experiments showed that MEDIATOR15 (MED15) is expressed in the same cells in the embryo as WRI1. We found that the Arabidopsis (Arabidopsis thaliana) MED15 subunit of the Mediator complex interacts directly with WRI1 in the nucleus. Overexpression of MED15 or WRI1 increased transcript levels of WRI1 target genes involved in glycolysis and fatty acid biosynthesis; these genes were down-regulated in wild-type or WRI1-overexpressing plants by silencing of MED15 However, overexpression of MED15 in the wri1 mutant also increased transcript levels of WRI1 target genes, suggesting that MED15 also may act with other TFs to activate downstream lipid-related genes. Chromatin immunoprecipitation assays confirmed the association of MED15 with six WRI1 target gene promoters. Additionally, silencing of MED15 resulted in reduced fatty acid content in seedlings and mature seeds, whereas MED15 overexpression increased fatty acid content in both developmental stages. Similar results were found in wri1 mutant and WRI1 overexpression lines. Together, our results indicate that the WRI1/MED15 complex transcriptionally regulates glycolysis-related and fatty acid biosynthetic genes during embryogenesis. © 2016 American Society of Plant Biologists. All Rights Reserved.

MEditerranean Supersite Volcanoes (MED-SUV) project: from objectives to results

Science.gov (United States)

Puglisi, Giuseppe; Spampinato, Letizia

2017-04-01

The MEditerranean Supersite Volcanoes (MED-SUV) was a FP7 3-year lasting project aimed at improving the assessment of volcanic hazards at two of the most active European volcanic areas - Campi Flegrei/Vesuvius and Mt. Etna. More than 3 million people are exposed to potential hazards in the two areas, and the geographic location of the volcanoes increases the number of people extending the impact to a wider region. MED-SUV worked on the (1) optimisation and integration of the existing and new monitoring systems, (2) understanding of volcanic processes, and on the (3) relationship between the scientific and end-user communities. MED-SUV fully exploited the unique multidisciplinary long-term in-situ datasets available for these volcanoes and integrated them with Earth observations. Technological developments and implemented algorithms allowed better constraint of pre-, sin- and post-eruptive phases. The wide range of styles and intensities of the volcanic phenomena observed at the targeted volcanoes - archetypes of 'closed' and 'open' conduit systems - observed by using the long-term multidisciplinary datasets, exceptionally upgraded the understanding of a variety of geo-hazards. Proper experiments and studies were carried out to advance the understanding of the volcanoes' internal structure and processes, and to recognise signals related to impending unrest/eruptive phases. Indeed, the hazard quantitative assessment benefitted from the outcomes of these studies and from their integration with cutting edge monitoring approaches, thus leading to step-changes in hazard awareness and preparedness, and leveraging the close relationship between scientists, SMEs, and end-users. Among the MED-SUV achievements, we can list the (i) implementation of a data policy compliant with the GEO Open Data Principles for ruling the exploitation and shared use of the project outcomes; (ii) MED-SUV e-infrastructure creation as test bed for designing an interoperable infrastructure to

Using polysaccharides against cancer

Directory of Open Access Journals (Sweden)

E. Azarnoosh

2017-11-01

Full Text Available Background and objectives: Nowadays cancer is one of the most important concerns of the society. The adverse effects of common therapeutics and resistance of some cancerous cells to treatment have brought the necessity of new approaches towards the issue. Polysaccharides are a group of carbohydrates found in natural sources. In the present article, our goal was to show the positive effects of carbohydrates (especially polysaccharides in cancer treatment, based on literature review. Methods: The literature review was carried out between 1990 and 2017 inclusive using the following search terms: cancer, carbohydrate and polysaccharide and was performed with use of Google scholar, Medline, Scopus, PubMed, Elsevier and other similar data banks, related to medicine and pharmaceutical fields. Results: Plants like Lyceum barbarum, Astragalus membrannceous, Panax ginseng, and Antrodia camphorate have been studied with promising effects in combating cancerous cells. The polysaccharides from these plants have benefits with numerous mechanisms such as apoptosis, inhibition of angiogenesis, anti-proliferation, immunomodulation, tumor suppression, and increase in macrophage activity. Other studies showed over 200 mushrooms with anticancer effects, especially basidiomycetes (e.g. Ganoderma lucidum. Sulfated polysaccharides found in sea and animals or even a few bacteria like E. coli showed to be useful in cancer. Conclusion: Scientists are realizing the importance of natural drugs and polysaccharide as good and available sources that could give a bright future for prevention, cure and palliative therapy in cancer.

Imaging in oral cancers

International Nuclear Information System (INIS)

Arya, Supreeta; Chaukar, Devendra; Pai, Prathamesh

2012-01-01

Oral cavity squamous cell cancers form a significant percentage of the cancers seen in India. While clinical examination allows direct visualization, it cannot evaluate deep extension of disease. Cross-sectional imaging has become the cornerstone in the pretreatment evaluation of these cancers and provides accurate information about the extent and depth of disease that can help decide the appropriate management strategy and indicate prognosis. Early cancers are treated with a single modality, either surgery or radiotherapy while advanced cancers are offered a combination of surgery, radiotherapy and chemotherapy. Imaging can decide resectability, help plan the precise extent of resection, and indicate whether organ conservation therapy should be offered. Quality of life issues necessitate preservation of form and function and pretreatment imaging helps plan appropriate reconstruction and counsel patients regarding lifestyle changes. Oral cavity has several subsites and the focus of the review is squamous cancers of the gingivobuccal region, oral tongue and retromolar trigone as these are most frequently encountered in the subcontinent. References for this review were identified by searching Medline and PubMed databases. Only articles published in English language literature were selected. This review aims to familiarize the radiologist with the relevant anatomy of the oral cavity, discuss the specific issues that influence prognosis and management at the above subsites, the optimal imaging methods, the role of imaging in accurately staging these cancers and in influencing management. A checklist for reporting will emphasize the information to be conveyed by the radiologist

 Cancer palliation in primary care - what is good and bad?

DEFF Research Database (Denmark)

Neergaard, Mette Asbjørn

 CANCER PALLIATION IN PRIMARY CARE -WHAT IS GOOD AND BAD?MA Neergaard, MD, specialist in general medicine, PhD student*F Olesen, general practitioner, Dr.Med.Sci., professor* J Soendergaard, general practitioner, senior researcher, PhD*AB Jensen, MD, consultant in oncology, PhD** *The Research Unit...... sectors. Methods. A series of focus group interviews is presently being conducted with participation of relatives of recently deceased cancer patients, GPs, community nurses and hospital physicians working with palliative patients. The interviews are transcribed and analysed  according...

Discrepancies among Scopus, Web of Science, and PubMed coverage of funding information in medical journal articles.

Science.gov (United States)

Kokol, Peter; Vošner, Helena Blažun

2018-01-01

The overall aim of the present study was to compare the coverage of existing research funding information for articles indexed in Scopus, Web of Science, and PubMed databases. The numbers of articles with funding information published in 2015 were identified in the three selected databases and compared using bibliometric analysis of a sample of twenty-eight prestigious medical journals. Frequency analysis of the number of articles with funding information showed statistically significant differences between Scopus, Web of Science, and PubMed databases. The largest proportion of articles with funding information was found in Web of Science (29.0%), followed by PubMed (14.6%) and Scopus (7.7%). The results show that coverage of funding information differs significantly among Scopus, Web of Science, and PubMed databases in a sample of the same medical journals. Moreover, we found that, currently, funding data in PubMed is more difficult to obtain and analyze compared with that in the other two databases.

Med H.C. Andersen i Portugal år 1866

DEFF Research Database (Denmark)

Skousbøll, Karin

2004-01-01

ankomst med diligence fra Spanien ind over fastlandet til Lissabon, men også rundt i byen, i omegnen og til havnebyen Setubal. Det indsamlede billedstof som underbygger teksten er dels historisk stof indhentet fra Det kg. Bibliotek o.a. kilder og dels fremskaffet fra Portugals arkiver og de respektive...

Body composition changes in females treated for breast cancer: a review of the evidence

OpenAIRE

Sheean, Patricia M.; Hoskins, Kent; Stolley, Melinda

2012-01-01

Body composition changes cannot be precisely captured using body weight or body mass index measures. Therefore, the primary purpose of this review was to characterize the patterns of body composition change in females treated for breast cancer including only studies that utilize imaging technologies to quantify adipose tissue and lean body mass (LBM). We reviewed PubMed for studies published between 1971–2012 involving females diagnosed with breast cancer where computed axial tomography (CAT)...

Spilleregler i musikterapi med voksne - oversigter fra faglitteraturen

Directory of Open Access Journals (Sweden)

Ulla Holck

2005-02-01

Full Text Available Artiklen gennemgår udvalgt faglitteratur, der på et overordnet plan beskriver typer af spilleregler i musikterapi med (fortrinsvis voksne klientgrupper. Udgangspunktet er Priestleys anvendelse af begrebet, og hendes inddeling af spilleregler i forhold til forskellige teknikker gennemgås, efterfulgt af en præsentation af opdelinger lavet af henholdsvis Pedersen & Scheiby, Bruscia og Wigram. En af forskellene på opfattelsen af spillereglernes karakter og anvendelse handler om, hvorvidt spillereglerne udelukkende bør have et referentielt indhold med udgangspunkt i klientens psykiske materiale, eller om også rent musikalske (eller nonreferentiellespilleregler kan siges at have en terapeutisk effekt. Artiklens forfatter ser i stedet spørgsmålet i lyset af mange klienters behov for en gradvis introduktion til klinisk improvisation og inddrager i den sammenhæng litteratur om introduktion og assessment af bl.a. Wigram, Hannibal og Jensen. Artiklen er den første i en serie, hvis overordnede mål er at indsamle viden og erfaring om anvendelse af spilleregler i forhold til forskellige klientgrupper. Anden del omhandler udvikling af spilleregler i forhold til børneklientgrupper og findes i næste kapitel i dette årsskrift.

Med Diet 4.0: the Mediterranean diet with four sustainable benefits.

Science.gov (United States)

Dernini, S; Berry, E M; Serra-Majem, L; La Vecchia, C; Capone, R; Medina, F X; Aranceta-Bartrina, J; Belahsen, R; Burlingame, B; Calabrese, G; Corella, D; Donini, L M; Lairon, D; Meybeck, A; Pekcan, A G; Piscopo, S; Yngve, A; Trichopoulou, A

2017-05-01

To characterize the multiple dimensions and benefits of the Mediterranean diet as a sustainable diet, in order to revitalize this intangible food heritage at the country level; and to develop a multidimensional framework - the Med Diet 4.0 - in which four sustainability benefits of the Mediterranean diet are presented in parallel: major health and nutrition benefits, low environmental impacts and richness in biodiversity, high sociocultural food values, and positive local economic returns. A narrative review was applied at the country level to highlight the multiple sustainable benefits of the Mediterranean diet into a single multidimensional framework: the Med Diet 4.0. Setting/subjects We included studies published in English in peer-reviewed journals that contained data on the characterization of sustainable diets and of the Mediterranean diet. The methodological framework approach was finalized through a series of meetings, workshops and conferences where the framework was presented, discussed and ultimately refined. The Med Diet 4.0 provides a conceptual multidimensional framework to characterize the Mediterranean diet as a sustainable diet model, by applying principles of sustainability to the Mediterranean diet. By providing a broader understanding of the many sustainable benefits of the Mediterranean diet, the Med Diet 4.0 can contribute to the revitalization of the Mediterranean diet by improving its current perception not only as a healthy diet but also a sustainable lifestyle model, with country-specific and culturally appropriate variations. It also takes into account the identity and diversity of food cultures and systems, expressed within the notion of the Mediterranean diet, across the Mediterranean region and in other parts of the world. Further multidisciplinary studies are needed for the assessment of the sustainability of the Mediterranean diet to include these new dimensions.

Screening for cervical cancer in low-resource settings in 2011.

Science.gov (United States)

Tambouret, Rosemary

2013-06-01

Cervical cancer remains the most common malignancy in women living in low- and middle-income countries, despite the decline of the disease in countries where cervical cytology screening programs have been implemented. To review the current incidence of cervical cancer in low-resource countries, the availability and types of screening programs, and the treatment options. Literature review through PubMed, Internet search, and personal communication. Although data are incomplete, available figures confirm that the rate of cervical cancer deaths and the availability of cervical cancer screening programs are inversely proportional and vary, in general, by the wealth of the nation. Despite the success of cervical cytology screening, many major health care organizations have abandoned screening by cytology in favor of direct visualization methods with immediate treatment of lesions by cryotherapy provided by trained, nonmedical personnel.

Evidence of peripheral nerve blocks for cancer-related pain

DEFF Research Database (Denmark)

Klepstad, P; Kurita, G P; Mercadante, S

2015-01-01

The European Association for Palliative Care has initiated a comprehensive program to achieve an over-all review of the evidence of multiple cancer pain management strategies in order to extend the current guideline for treatment of cancer pain. The present systematic review analyzed the existing...... evidence of analgesic efficacy for peripheral nerve blocks in adult patients with cancer. A search strategy was elaborated with words related to cancer, pain, peripheral nerve and block. The search was performed in PubMed, EMBASE, and Cochrane for the period until February 2014. The number of abstracts...... retrieved was 155. No controlled studies were identified. Sixteen papers presented a total of 79 cases. The blocks applied were paravertebral blocks (10 cases), blocks in the head region (2 cases), plexus blocks (13 cases), intercostal blocks (43 cases) and others (11 cases). In general, most cases reported...

Musikbranschen i förändring : Artistens möjligheter med och utan skivbolag

OpenAIRE

Järnström, Sofia Maria

2011-01-01

Syftet med mitt examensarbete är att undersöka i vilken utsträckning artister kan nå en publik utan att ingå ett skivkontrakt och att klargöra för vilka kanaler som finns tillgäng-liga för självständig marknadsföring. Undersökningen är kvalitativ och jag kommer att fokusera på fyra intervjuer med personer inom branschen. Jag fokuserar på dessa frågor: 1) Hur kan en artist nå ut med sin musik, utan att ha ett skivbolag bakom sig som marknadsförare och distributör? 2) Vilka nya...

Amphotericin B lipid soluble formulations versus amphotericin B in cancer patients with neutropenia

DEFF Research Database (Denmark)

Johansen, Helle Krogh; Gøtzsche, Peter C

2014-01-01

a fever. OBJECTIVES: To compare the benefits and harms of lipid soluble formulations of amphotericin B with conventional amphotericin B in cancer patients with neutropenia. SEARCH METHODS: We searched PubMed from 1966 to 7 July 2014 and the reference lists of identified articles. SELECTION CRITERIA...

PubMed-based quantitative analysis of biomedical publications in the SAARC countries: 1985-2009.

Science.gov (United States)

Azim Majumder, Md Anwarul; Shaban, Sami F; Rahman, Sayeeda; Rahman, Nuzhat; Ahmed, Moslehuddin; Bin Abdulrahman, Khalid A; Islam, Ziauddin

2012-09-01

To conduct a geographical analysis of biomedical publications from the South Asian Association for Regional Cooperation (SAARC) countries over the past 25 years (1985-2009) using the PubMed database. A qualitative study. Web-based search during September 2010. A data extraction program, developed by one of the authors (SFS), was used to extract the raw publication counts from the downloaded PubMed data. A search of PubMed was performed for all journals indexed by selecting the advanced search option and entering the country name in the 'affiliation' field. The publications were normalized by total population, adult illiteracy rate, gross domestic product (GDP), secondary school enrollment ratio and Internet usage rate. The number of PubMed-listed papers published by the SAARC countries over the last 25 years totalled 141,783, which is 1.1% of the total papers indexed by PubMed in the same period. India alone produced 90.5% of total publications generated by SAARC countries. The average number of papers published per year from 1985 to 2009 was 5671 and number of publication increased approximately 242-fold. Normalizing by the population (per million) and GDP (per billion), India (133, 27.6%) and Nepal (323, 37.3%) had the highest publications respectively. There was a marked imbalance among the SAARC countries in terms of biomedical research and publication. Because of huge population and the high disease burden, biomedical research and publication output should receive special attention to formulate health policies, re-orient medical education curricula, and alleviate diseases and poverty.

Hvordan får man succes med Business Intelligence anvendt til data på danske universiteter?

DEFF Research Database (Denmark)

Gaardboe, Rikke; Nyvang, Tom; Jensen, Erling

brug, brugertilfredshed og individuel impact. 274 BI-brugere svarede på spørgeskemaet. Resultatet er at systemkvalitet og informationskvalitet er positiv og signifikant relateret til brugertilfredshed. Og brugertilfredsheden er positiv og signifikant med individual impact. Des højere systemkvalitet......, des mere bruger brugerne BI. Men brug af BI er ikke signifikant med individual impact. At den enkelte BI bruger oplever individual impact er ikke ensbetydende med organisatorisk impact. Derfor blev der gennemført 7 semi-strukturerede interviews. Formålet var at identificere den organisatoriske impact...

Clinical safety of magnetic resonance imaging in patients with implanted SynchroMed EL infusion pumps

International Nuclear Information System (INIS)

Diehn, Felix E.; Wood, Christopher P.; Watson, Robert E.; Hunt, Christopher H.; Mauck, William D.; Burke, Michelle M.

2011-01-01

Patients with implanted SynchroMed spinal infusion pumps (Medtronic, Inc., Minneapolis, MN) routinely undergo magnetic resonance imaging at our institution. In August 2008, Medtronic issued an urgent medical device correction report regarding several pumps. Because of the rare potential ''for a delay in the return of proper drug infusion'' and ''for a delay in the logging of motor stall events,'' ''a patient's pump must be interrogated after MRI exposure in order to confirm proper pump functionality.'' This is particularly important in patients receiving intrathecal baclofen, for whom a delay in return of proper pump infusion could lead to life-threatening baclofen withdrawal syndrome. The objective of this report is to present our experience and protocol of performing magnetic resonance imaging in patients with implanted SynchroMed EL pumps. We retrospectively reviewed records of 86 patients with implanted SynchroMed EL spinal infusion pumps who underwent 112 examinations on 1.5-T magnetic resonance imaging scanners from September 1, 1998 to July 7, 2004. No SynchroMed EL pumps were damaged by magnetic resonance imaging, and the programmable settings remained unchanged in all patients. Our data suggest that SynchroMed EL pump malfunction is indeed rare after routine clinical 1.5-T magnetic resonance imaging examinations. However, based on the Medtronic correction report, we perform pump interrogation before and after imaging. (orig.)

MedTime: a temporal information extraction system for clinical narratives.

Science.gov (United States)

Lin, Yu-Kai; Chen, Hsinchun; Brown, Randall A

2013-12-01

Temporal information extraction from clinical narratives is of critical importance to many clinical applications. We participated in the EVENT/TIMEX3 track of the 2012 i2b2 clinical temporal relations challenge, and presented our temporal information extraction system, MedTime. MedTime comprises a cascade of rule-based and machine-learning pattern recognition procedures. It achieved a micro-averaged f-measure of 0.88 in both the recognitions of clinical events and temporal expressions. We proposed and evaluated three time normalization strategies to normalize relative time expressions in clinical texts. The accuracy was 0.68 in normalizing temporal expressions of dates, times, durations, and frequencies. This study demonstrates and evaluates the integration of rule-based and machine-learning-based approaches for high performance temporal information extraction from clinical narratives. Copyright © 2013 Elsevier Inc. All rights reserved.

What time-lag for a retraction search on PubMed?

Science.gov (United States)

Decullier, Evelyne; Huot, Laure; Maisonneuve, Hervé

2014-06-25

To investigate fraud and errors, scientists have studied cohorts of retraction notices. These researches have been performed using a PubMed search on publication type "retraction of publication" which retrieves the notices of the retractions. We assessed the stability of the indexation of retraction notices over a 15-month period and what was the time-lag to get stability. A search on notices of retraction issued in 2008 was repeated every 3 months during 15 months from February 2011. The first search resulted in 237 notices of retraction. Throughout the study period, 14 discrepancies with the initial search were observed (6%). We found that the number of retraction notices became stable 35 months after the retraction. The time-lag observed in this study has to be taken into account when performing a PubMed search.

Copenhagen ITS: Forsøg med wifi-baseret positionering på H.C. Andersens Boulevard

DEFF Research Database (Denmark)

Høeg, Per; Nielsen, Thomas Sick; Olsen, Allan

2017-01-01

I samarbejde med Københavns Kommune afprøvede CITS konsortiet potentialet i wifi-baseret positionering med en forsøgsstrækning på H.C. Andersens Boulevard i vintermånederne 2014-2015. Wifi-positioneringen giver et nyt datagrundlag for trafik og bylivsundersøgelser, herunder f.eks. et grundlag...

The effect of fiber diet on colonic cancer formation: the role of butyrate

Directory of Open Access Journals (Sweden)

Ari F. Syam

2003-06-01

Full Text Available The majority of colon cancers occur sporadically. They are thougth to be caused by non-inherited factors such as a combination of diet and environmental factors, which result in somatic mutations of specific genes. Among dietary factors butyrate which is derived from fermentable fibers may have important role as chemoprotector against colorectal cancer. The source of butyrate in daily diet mostly come from wheat products especially wheat bran. At molecular level, butyrate causes hystone acetylation, favours differentiation, induces apoptosis and regulates the expressions of various oncogens. These effects suggest that butyrate may be protective against colorectal cancers. (Med J Indones 2003; 12: 127-31Keywords: colon cancer, dietary fiber, apoptosis

Oligometastatic Disease in Upper Gastrointestinal Cancer - How to Proceed?

Science.gov (United States)

Chiapponi, Costanza; Berlth, Felix; Plum, Patrick S; Betzler, Christopher; Stippel, Dirk L; Popp, Felix; Bruns, Christiane J

2017-03-01

In the present study we review and discuss the current evidence and suggest how to proceed in the management of oligometastatic disease in upper gastrointestinal cancer. An electronic search of the PubMed database for relevant articles was performed. Both the search for 'oligometastasis', 'oligometastases', 'oligometastatic', 'oligometastatic disease' as well as 'esophageal' and 'esophageal cancer' and the search for 'oligometastasis', 'oligometastases', 'oligometastatic', 'oligometastatic disease' as well as 'gastric', 'gastric cancer', 'stomach', and 'stomach cancer' yielded very few studies. Most data need to be extrapolated in general studies on oligometastatic diseases of different origins. No randomized controlled trial could be found. In the absence of data to formulate recommendations on how to proceed in the treatment of oligometastatic disease in upper gastrointestinal cancer, a more aggressive treatment of oligometastatic disease can be considered in patients whose tumors show a more favorable neoplastic behavior after the 'test of time'. The RENAISSANCE study will certainly deliver important data regarding this aspect.

Connecting the dots between PubMed abstracts.

Directory of Open Access Journals (Sweden)

M Shahriar Hossain

Full Text Available BACKGROUND: There are now a multitude of articles published in a diversity of journals providing information about genes, proteins, pathways, and diseases. Each article investigates subsets of a biological process, but to gain insight into the functioning of a system as a whole, we must integrate information from multiple publications. Particularly, unraveling relationships between extra-cellular inputs and downstream molecular response mechanisms requires integrating conclusions from diverse publications. METHODOLOGY: We present an automated approach to biological knowledge discovery from PubMed abstracts, suitable for "connecting the dots" across the literature. We describe a storytelling algorithm that, given a start and end publication, typically with little or no overlap in content, identifies a chain of intermediate publications from one to the other, such that neighboring publications have significant content similarity. The quality of discovered stories is measured using local criteria such as the size of supporting neighborhoods for each link and the strength of individual links connecting publications, as well as global metrics of dispersion. To ensure that the story stays coherent as it meanders from one publication to another, we demonstrate the design of novel coherence and overlap filters for use as post-processing steps. CONCLUSIONS: WE DEMONSTRATE THE APPLICATION OF OUR STORYTELLING ALGORITHM TO THREE CASE STUDIES: i a many-one study exploring relationships between multiple cellular inputs and a molecule responsible for cell-fate decisions, ii a many-many study exploring the relationships between multiple cytokines and multiple downstream transcription factors, and iii a one-to-one study to showcase the ability to recover a cancer related association, viz. the Warburg effect, from past literature. The storytelling pipeline helps narrow down a scientist's focus from several hundreds of thousands of relevant documents to only

Connecting the Dots between PubMed Abstracts

Science.gov (United States)

Hossain, M. Shahriar; Gresock, Joseph; Edmonds, Yvette; Helm, Richard; Potts, Malcolm; Ramakrishnan, Naren

2012-01-01

Background There are now a multitude of articles published in a diversity of journals providing information about genes, proteins, pathways, and diseases. Each article investigates subsets of a biological process, but to gain insight into the functioning of a system as a whole, we must integrate information from multiple publications. Particularly, unraveling relationships between extra-cellular inputs and downstream molecular response mechanisms requires integrating conclusions from diverse publications. Methodology We present an automated approach to biological knowledge discovery from PubMed abstracts, suitable for “connecting the dots” across the literature. We describe a storytelling algorithm that, given a start and end publication, typically with little or no overlap in content, identifies a chain of intermediate publications from one to the other, such that neighboring publications have significant content similarity. The quality of discovered stories is measured using local criteria such as the size of supporting neighborhoods for each link and the strength of individual links connecting publications, as well as global metrics of dispersion. To ensure that the story stays coherent as it meanders from one publication to another, we demonstrate the design of novel coherence and overlap filters for use as post-processing steps. Conclusions We demonstrate the application of our storytelling algorithm to three case studies: i) a many-one study exploring relationships between multiple cellular inputs and a molecule responsible for cell-fate decisions, ii) a many-many study exploring the relationships between multiple cytokines and multiple downstream transcription factors, and iii) a one-to-one study to showcase the ability to recover a cancer related association, viz. the Warburg effect, from past literature. The storytelling pipeline helps narrow down a scientist's focus from several hundreds of thousands of relevant documents to only around a hundred

PubMed Central Canada: Beyond an Open Access Repository?

Science.gov (United States)

Nariani, Rajiv

2013-01-01

PubMed Central Canada (PMC Canada) represents a partnership between the Canadian Institutes of Health Research (CIHR), the National Research Council's Canada Institute for Scientific and Technical Information (NRC-CISTI), and the National Library of Medicine of the US. The present study was done to gauge faculty awareness about the CIHR Policy on…

Udstilling af børn og fostre med misdannelser

DEFF Research Database (Denmark)

Meyer, Ion

2008-01-01

Artiklen beskriver baggrunden for etableringen af de første anatomiske samlinger og de første samlinger med teratologiske præparater i Sct. Petersborg og Berlin. Den Saxtorphske Samling på Medicinsk Museion indeholder den største samling af teratologiske præparater i Danmark, og bagrunden for sam...

pubmed.mineR: an R package with text-mining algorithms to analyse PubMed abstracts.

Science.gov (United States)

Rani, Jyoti; Shah, A B Rauf; Ramachandran, Srinivasan

2015-10-01

The PubMed literature database is a valuable source of information for scientific research. It is rich in biomedical literature with more than 24 million citations. Data-mining of voluminous literature is a challenging task. Although several text-mining algorithms have been developed in recent years with focus on data visualization, they have limitations such as speed, are rigid and are not available in the open source. We have developed an R package, pubmed.mineR, wherein we have combined the advantages of existing algorithms, overcome their limitations, and offer user flexibility and link with other packages in Bioconductor and the Comprehensive R Network (CRAN) in order to expand the user capabilities for executing multifaceted approaches. Three case studies are presented, namely, 'Evolving role of diabetes educators', 'Cancer risk assessment' and 'Dynamic concepts on disease and comorbidity' to illustrate the use of pubmed.mineR. The package generally runs fast with small elapsed times in regular workstations even on large corpus sizes and with compute intensive functions. The pubmed.mineR is available at http://cran.rproject. org/web/packages/pubmed.mineR.

Langtidsbivirkninger efter intenderet kurativ strålebeahdnling for prostata cancer:med brug af en NI TI stent og MRI indtegning

OpenAIRE

Sander, Lotte

2016-01-01

A significant increase in the prostate cancer incidence has made prostate cancer a major health problem in recent years. Because of the often but unfortunately not always indolent nature of the disease, over-diagnosis and over-treatment are relevant clinical and ethic dilemmas. External beam radiotherapy is a well established treatment modality for prostate cancer. Accuracy and precision are key words with regard to optimal survival and minimal toxicity in modern radiotherapy and are fundamen...

Methods and pitfalls in searching drug safety databases utilising the Medical Dictionary for Regulatory Activities (MedDRA).

Science.gov (United States)

Brown, Elliot G

2003-01-01

The Medical Dictionary for Regulatory Activities (MedDRA) is a unified standard terminology for recording and reporting adverse drug event data. Its introduction is widely seen as a significant improvement on the previous situation, where a multitude of terminologies of widely varying scope and quality were in use. However, there are some complexities that may cause difficulties, and these will form the focus for this paper. Two methods of searching MedDRA-coded databases are described: searching based on term selection from all of MedDRA and searching based on terms in the safety database. There are several potential traps for the unwary in safety searches. There may be multiple locations of relevant terms within a system organ class (SOC) and lack of recognition of appropriate group terms; the user may think that group terms are more inclusive than is the case. MedDRA may distribute terms relevant to one medical condition across several primary SOCs. If the database supports the MedDRA model, it is possible to perform multiaxial searching: while this may help find terms that might have been missed, it is still necessary to consider the entire contents of the SOCs to find all relevant terms and there are many instances of incomplete secondary linkages. It is important to adjust for multiaxiality if data are presented using primary and secondary locations. Other sources for errors in searching are non-intuitive placement and the selection of terms as preferred terms (PTs) that may not be widely recognised. Some MedDRA rules could also result in errors in data retrieval if the individual is unaware of these: in particular, the lack of multiaxial linkages for the Investigations SOC, Social circumstances SOC and Surgical and medical procedures SOC and the requirement that a PT may only be present under one High Level Term (HLT) and one High Level Group Term (HLGT) within any single SOC. Special Search Categories (collections of PTs assembled from various SOCs by

Reconstitution of active human core Mediator complex reveals a critical role of the MED14 subunit.

Science.gov (United States)

Cevher, Murat A; Shi, Yi; Li, Dan; Chait, Brian T; Malik, Sohail; Roeder, Robert G

2014-12-01

The evolutionarily conserved Mediator complex is a critical coactivator for RNA polymerase II (Pol II)-mediated transcription. Here we report the reconstitution of a functional 15-subunit human core Mediator complex and its characterization by functional assays and chemical cross-linking coupled to MS (CX-MS). Whereas the reconstituted head and middle modules can stably associate, basal and coactivator functions are acquired only after incorporation of MED14 into the bimodular complex. This results from a dramatically enhanced ability of MED14-containing complexes to associate with Pol II. Altogether, our analyses identify MED14 as both an architectural and a functional backbone of the Mediator complex. We further establish a conditional requirement for metazoan-specific MED26 that becomes evident in the presence of heterologous nuclear factors. This general approach paves the way for systematic dissection of the multiple layers of functionality associated with the Mediator complex.

Amphotericin B versus fluconazole for controlling fungal infections in neutropenic cancer patients

DEFF Research Database (Denmark)

Johansen, Helle Krogh; Gøtzsche, Peter C

2014-01-01

BACKGROUND: Systemic fungal infection is considered to be an important cause of morbidity and mortality in cancer patients, particularly those with neutropenia. Antifungal drugs are often given prophylactically, or empirically to patients with persistent fever. OBJECTIVES: To compare the effect...... of fluconazole and amphotericin B on morbidity and mortality in patients with cancer complicated by neutropenia. SEARCH METHODS: We searched PubMed from 1966 to 7 July 2014 and the reference lists of identified articles. SELECTION CRITERIA: Randomised clinical trials comparing fluconazole with amphotericin B...

Competency-structured case discussion in the morning meeting: enhancing CanMEDS integration in daily practice

Directory of Open Access Journals (Sweden)

Hassan IS

2015-05-01

Full Text Available Imad Salah Hassan, Hadi Kuriry, Lina Al Ansari, Ali Al-Khathami, Mohammed Al Qahtani, Thari Al Anazi, Mahfooz Farooqui, Hamdan Al Jahdali Department of Medicine 1443, King Saud bin Abdulaziz University for Health Sciences, King Abdulaziz Medical City, Riyadh, Kingdom of Saudi Arabia Abstract: Outcome-focused, competency-based educational curricula have become the norm in residency training programs. The Canadian Medical Education Directives for Specialists (CanMEDS framework is one example of such a curriculum. However, models for incorporating all the competencies in everyday clinical practice have been difficult to accomplish. In this manuscript, a CanMEDS, competency-structured, acute case discussion in a regular morning meeting was undertaken. All the diagnostic and therapeutic interventions were explicitly organized and discussed under their respective CanMEDS competency headings. Post exercise, the majority of residents felt that they were more competent in all the competencies and indicated their willingness to continue having similarly structured acute case discussions in the future. Keywords: CanMEDS roles, residents, morning meeting

The application of crowdsourcing approaches to cancer research: a systematic review.

Science.gov (United States)

Lee, Young Ji; Arida, Janet A; Donovan, Heidi S

2017-11-01

Crowdsourcing is "the practice of obtaining participants, services, ideas, or content by soliciting contributions from a large group of people, especially via the Internet." (Ranard et al. J. Gen. Intern. Med. 29:187, 2014) Although crowdsourcing has been adopted in healthcare research and its potential for analyzing large datasets and obtaining rapid feedback has recently been recognized, no systematic reviews of crowdsourcing in cancer research have been conducted. Therefore, we sought to identify applications of and explore potential uses for crowdsourcing in cancer research. We conducted a systematic review of articles published between January 2005 and June 2016 on crowdsourcing in cancer research, using PubMed, CINAHL, Scopus, PsychINFO, and Embase. Data from the 12 identified articles were summarized but not combined statistically. The studies addressed a range of cancers (e.g., breast, skin, gynecologic, colorectal, prostate). Eleven studies collected data on the Internet using web-based platforms; one recruited participants in a shopping mall using paper-and-pen data collection. Four studies used Amazon Mechanical Turk for recruiting and/or data collection. Study objectives comprised categorizing biopsy images (n = 6), assessing cancer knowledge (n = 3), refining a decision support system (n = 1), standardizing survivorship care-planning (n = 1), and designing a clinical trial (n = 1). Although one study demonstrated that "the wisdom of the crowd" (NCI Budget Fact Book, 2017) could not replace trained experts, five studies suggest that distributed human intelligence could approximate or support the work of trained experts. Despite limitations, crowdsourcing has the potential to improve the quality and speed of research while reducing costs. Longitudinal studies should confirm and refine these findings. © 2017 The Authors. Cancer Medicine published by John Wiley & Sons Ltd.

The Mediator subunit MED23 couples H2B mono-ubiquitination to transcriptional control and cell fate determination.

Science.gov (United States)

Yao, Xiao; Tang, Zhanyun; Fu, Xing; Yin, Jingwen; Liang, Yan; Li, Chonghui; Li, Huayun; Tian, Qing; Roeder, Robert G; Wang, Gang

2015-12-02

The Mediator complex orchestrates multiple transcription factors with the Pol II apparatus for precise transcriptional control. However, its interplay with the surrounding chromatin remains poorly understood. Here, we analyze differential histone modifications between WT and MED23(-/-) (KO) cells and identify H2B mono-ubiquitination at lysine 120 (H2Bub) as a MED23-dependent histone modification. Using tandem affinity purification and mass spectrometry, we find that MED23 associates with the RNF20/40 complex, the enzyme for H2Bub, and show that this association is critical for the recruitment of RNF20/40 to chromatin. In a cell-free system, Mediator directly and substantially increases H2Bub on recombinant chromatin through its cooperation with RNF20/40 and the PAF complex. Integrative genome-wide analyses show that MED23 depletion specifically reduces H2Bub on a subset of MED23-controlled genes. Importantly, MED23-coupled H2Bub levels are oppositely regulated during myogenesis and lung carcinogenesis. In sum, these results establish a mechanistic link between the Mediator complex and a critical chromatin modification in coordinating transcription with cell growth and differentiation. © 2015 The Authors.

The Web-based CanMEDS Resident Learning Portfolio Project (WEBCAM): how we got started.

Science.gov (United States)

Glen, Peter; Balaa, Fady; Momoli, Franco; Martin, Louise; Found, Dorothy; Arnaout, Angel

2016-12-01

The CanMEDS framework is ubiquitous in Canadian postgraduate medical education; however, training programs do not have a universal method of assessing competence. We set out to develop a novel portfolio that allowed trainees to generate a longitudinal record of their training and development within the framework. The portfolio provided an objective means for the residency program director to document and evaluate resident progress within the CanMEDS roles.

Elucidating high-dimensional cancer hallmark annotation via enriched ontology.

Science.gov (United States)

Yan, Shankai; Wong, Ka-Chun

2017-09-01

Cancer hallmark annotation is a promising technique that could discover novel knowledge about cancer from the biomedical literature. The automated annotation of cancer hallmarks could reveal relevant cancer transformation processes in the literature or extract the articles that correspond to the cancer hallmark of interest. It acts as a complementary approach that can retrieve knowledge from massive text information, advancing numerous focused studies in cancer research. Nonetheless, the high-dimensional nature of cancer hallmark annotation imposes a unique challenge. To address the curse of dimensionality, we compared multiple cancer hallmark annotation methods on 1580 PubMed abstracts. Based on the insights, a novel approach, UDT-RF, which makes use of ontological features is proposed. It expands the feature space via the Medical Subject Headings (MeSH) ontology graph and utilizes novel feature selections for elucidating the high-dimensional cancer hallmark annotation space. To demonstrate its effectiveness, state-of-the-art methods are compared and evaluated by a multitude of performance metrics, revealing the full performance spectrum on the full set of cancer hallmarks. Several case studies are conducted, demonstrating how the proposed approach could reveal novel insights into cancers. https://github.com/cskyan/chmannot. Copyright © 2017 Elsevier Inc. All rights reserved.

Experimental benchmarks and simulation of GAMMA-T for overcooling and undercooling transients in HTGRs coupled with MED desalination plants

International Nuclear Information System (INIS)

Kim, Ho Sik; Kim, In Hun; NO, Hee Cheon; Jin, Hyung Gon

2013-01-01

Highlights: ► The GAMMA-T code was well validated through benchmark experiments. ► Based on the KAIST coupling scheme, the GTHTR300 + MED systems were made. ► Safety analysis was performed for overcooling and undercooling accidents. ► In all accidents, maximum peak fuel temperatures were well below than 1600 °C. ► In all accidents, the HTGR + MED system could be operated continuously. -- Abstracts: The nuclear desalination based on the high temperature gas-cooled reactor (HTGR) with gas turbomachinery and multi-effect distillation (MED) is attracting attention because the coupling system can utilize the waste heat of the nuclear power system for the MED desalination system. In previous work, KAIST proposed the new HTGR + MED coupling scheme, evaluated desalination performance, and performed cost analysis for the system. In this paper, in order to confirm the safety and the performance of the coupling system, we performed the transient analysis with GAMMA-T (GAs Multidimensional Multicomponent mixture Analysis–Turbomachinery) code for the KAIST HTGR + MED systems. The experimental benchmarks of GAMMA-T code were set up before the transient analysis for several accident scenarios. The GAMMA-T code was well validated against steady state and transient scenarios of the He–Water test loop such as changes in water mass flow rate and water inlet temperatures. Then, for transient analysis, the GTHTR300 was chosen as a reference plant. The GTHTR300 + MED systems were made, based on the KAIST HTGR + MED coupling scheme. Transient analysis was performed for three kinds of accidents scenarios: (1) loss of heat rejection through MED plant, (2) loss of heat rejection through heat sink, and (3) overcooling due to abnormal cold temperature of seawater. In all kinds of accident scenarios, maximum peak fuel temperatures were well below than the fuel failure criterion, 1600 °C and the GTHTR300 + MED system could be operated continuously and safely. Specially, in the

Do language fluency and other socioeconomic factors influence the use of PubMed and MedlinePlus?

Science.gov (United States)

Sheets, L; Gavino, A; Callaghan, F; Fontelo, P

2013-01-01

Increased usage of MedlinePlus by Spanish-speakers was observed after introduction of MedlinePlus in Spanish. This probably reflects increased usage of MEDLINE and PubMed by those with greater fluency in the language in which it is presented; but this has never been demonstrated in English speakers. Evidence that lack of English fluency deters international healthcare personnel from using PubMed could support the use of multi-language search tools like Babel-MeSH. This study aims to measure the effects of language fluency and other socioeconomic factors on PubMed MEDLINE and MedlinePlus access by international users. We retrospectively reviewed server pageviews of PubMed and MedlinePlus from various periods of time, and analyzed them against country statistics on language fluency, GDP, literacy rate, Internet usage, medical schools, and physicians per capita, to determine whether they were associated. We found fluency in English to be positively associated with pageviews of PubMed and MedlinePlus in countries with high literacy rates. Spanish was generally found to be positively associated with pageviews of MedlinePlus en Español. The other parameters also showed varying degrees of association with pageviews. After adjusting for the other factors investigated in this study, language fluency was a consistently significant predictor of the use of PubMed, MedlinePlus English and MedlinePlus en Español. This study may support the need for multi-language search tools and may increase access of health information resources from non-English speaking countries.

Non-Coding RNAs and Endometrial Cancer

Directory of Open Access Journals (Sweden)

Cristina Vallone

2018-03-01

Full Text Available Non-coding RNAs (ncRNAs are involved in the regulation of cell metabolism and neoplastic transformation. Recent studies have tried to clarify the significance of these information carriers in the genesis and progression of various cancers and their use as biomarkers for the disease; possible targets for the inhibition of growth and invasion by the neoplastic cells have been suggested. The significance of ncRNAs in lung cancer, bladder cancer, kidney cancer, and melanoma has been amply investigated with important results. Recently, the role of long non-coding RNAs (lncRNAs has also been included in cancer studies. Studies on the relation between endometrial cancer (EC and ncRNAs, such as small ncRNAs or micro RNAs (miRNAs, transfer RNAs (tRNAs, ribosomal RNAs (rRNAs, antisense RNAs (asRNAs, small nuclear RNAs (snRNAs, Piwi-interacting RNAs (piRNAs, small nucleolar RNAs (snoRNAs, competing endogenous RNAs (ceRNAs, lncRNAs, and long intergenic ncRNAs (lincRNAs have been published. The recent literature produced in the last three years was extracted from PubMed by two independent readers, which was then selected for the possible relation between ncRNAs, oncogenesis in general, and EC in particular.

Du er god nok! Litteraturstudie om tilrettelegging av mestring for elever med dysleksi.

OpenAIRE

Loktu, Thea Amanda Hansen

2017-01-01

Bacheloroppgave, grunnskolelærerutdanning, 2017. Norsk: Temaet for oppgaven er mestring og dysleksi og omhandler hvorfor og til dels hvordan en særlig skal legge til rette for mestring hos elever med dysleksi. Oppgaven er fundert i både et samfunnsmessigperspektiv og et individperspektiv. Bacheloren søker å finne de momentene som påvirker læring for denne gruppen, med fokus på det helhetlige mennesket. Problemstillingen lyder slik: Hvorfor legge særlig til rette for mestring hos elever ...

One Health – Transdisziplinarität bei ZB MED

Directory of Open Access Journals (Sweden)

Seidlmayer, Eva

2017-12-01

Full Text Available By supporting disciplinary and interdisciplinary research in the fields of medicine, health care, nutritional, environmental and agricultural sciences ZB MED enables an integrated view on human health. The poster focuses on approach as well as as the underlying concepts. Additionally, the poster presents services for transdisciplinary research in the life sciences.

CredibleMeds.org: What does it offer?

Science.gov (United States)

Woosley, Raymond L; Black, Kristin; Heise, C William; Romero, Klaus

2018-02-01

Since the 1990s, when numerous non-cardiac drugs were first recognized to have the potential to prolong the QT interval and cause torsades de pointes (TdP), clinicians, drug regulators, drug developers, and clinical investigators have become aware of the complexities of assessing evidence and determining TdP causality for the many drugs being marketed or under development. To facilitate better understanding, the Arizona Center for Education and Research on Therapeutics, known as AZCERT, has developed the CredibleMeds.org website which includes QTdrugs, a listing of over 220 drugs placed in four risk categories based on their association with QT prolongation and TdP. Since the site was launched in 1999, it has become the single and most reliable source of information of its kind for patients, healthcare providers, and research scientists. Over 96,000 registered users rely on the QTdrugs database as their primary resource to inform their medication use, their prescribing or their clinical research into the impact of QT-prolonging drugs and drug-induced arrhythmias. The QTdrugs lists are increasingly used as the basis for clinical decision support systems in healthcare and for metrics of prescribing quality by healthcare insurers. A free smartphone app and an application program interface enable rapid and mobile access to the lists. Also, the CredibleMeds website offers numerous educational resources for patients, educators and healthcare providers that foster the safe use of medications. Copyright © 2018 Elsevier Inc. All rights reserved.

User needs analysis and usability assessment of DataMed - a biomedical data discovery index.

Science.gov (United States)

Dixit, Ram; Rogith, Deevakar; Narayana, Vidya; Salimi, Mandana; Gururaj, Anupama; Ohno-Machado, Lucila; Xu, Hua; Johnson, Todd R

2017-11-30

To present user needs and usability evaluations of DataMed, a Data Discovery Index (DDI) that allows searching for biomedical data from multiple sources. We conducted 2 phases of user studies. Phase 1 was a user needs analysis conducted before the development of DataMed, consisting of interviews with researchers. Phase 2 involved iterative usability evaluations of DataMed prototypes. We analyzed data qualitatively to document researchers' information and user interface needs. Biomedical researchers' information needs in data discovery are complex, multidimensional, and shaped by their context, domain knowledge, and technical experience. User needs analyses validate the need for a DDI, while usability evaluations of DataMed show that even though aggregating metadata into a common search engine and applying traditional information retrieval tools are promising first steps, there remain challenges for DataMed due to incomplete metadata and the complexity of data discovery. Biomedical data poses distinct problems for search when compared to websites or publications. Making data available is not enough to facilitate biomedical data discovery: new retrieval techniques and user interfaces are necessary for dataset exploration. Consistent, complete, and high-quality metadata are vital to enable this process. While available data and researchers' information needs are complex and heterogeneous, a successful DDI must meet those needs and fit into the processes of biomedical researchers. Research directions include formalizing researchers' information needs, standardizing overviews of data to facilitate relevance judgments, implementing user interfaces for concept-based searching, and developing evaluation methods for open-ended discovery systems such as DDIs. © The Author 2017. Published by Oxford University Press on behalf of the American Medical Informatics Association. All rights reserved. For Permissions, please email: journals.permissions@oup.com

Radical prostatectomy for high-risk prostate cancer.

Science.gov (United States)

Yossepowitch, Ofer; Eastham, James A

2008-06-01

Consensus recommendations for the identification and treatment of men whose apparent organ confined prostate cancer has high risk features are lacking. Despite ongoing refinements in surgical technique and improvements in morbidity and functional outcomes, the tradition of steering high-risk patients away from radical prostatectomy (RP) remains steadfast. We performed a medical literature search in English using MEDLINE/PubMed that addressed high risk prostate cancer. We analyzed the literature with respect to the historical evolution of this concept, current risk stratification schemes and treatment guidelines and related short and long term outcomes following RP. Contemporary evidence suggest that patients classified with high-risk prostate cancer by commonly used definitions do not have a uniformly poor prognosis after RP. Many cancers categorized clinically as high risk are actually pathologically confined to the prostate, and most men with such cancers who undergo RP are alive and free of additional therapy long after surgery. RP in the high-risk setting appears to be associated with a similar morbidity as in lower-risk patients. Men with clinically localized high-risk prostate cancer should not be categorically disqualified from local definitive therapy with RP. With careful attention to surgical technique, cancer control rates should improve further, and adverse effects on quality of life after RP should continue to decrease.

Clinical safety of magnetic resonance imaging in patients with implanted SynchroMed EL infusion pumps

Energy Technology Data Exchange (ETDEWEB)

Diehn, Felix E.; Wood, Christopher P.; Watson, Robert E.; Hunt, Christopher H. [Mayo Clinic, Department of Radiology, Rochester, MN (United States); Mauck, William D. [Mayo Clinic, Department of Anesthesiology, Rochester, MN (United States); Burke, Michelle M. [Mayo Clinic, Department of Psychiatry and Psychology, Rochester, MN (United States)

2011-02-15

Patients with implanted SynchroMed spinal infusion pumps (Medtronic, Inc., Minneapolis, MN) routinely undergo magnetic resonance imaging at our institution. In August 2008, Medtronic issued an urgent medical device correction report regarding several pumps. Because of the rare potential ''for a delay in the return of proper drug infusion'' and ''for a delay in the logging of motor stall events,'' ''a patient's pump must be interrogated after MRI exposure in order to confirm proper pump functionality.'' This is particularly important in patients receiving intrathecal baclofen, for whom a delay in return of proper pump infusion could lead to life-threatening baclofen withdrawal syndrome. The objective of this report is to present our experience and protocol of performing magnetic resonance imaging in patients with implanted SynchroMed EL pumps. We retrospectively reviewed records of 86 patients with implanted SynchroMed EL spinal infusion pumps who underwent 112 examinations on 1.5-T magnetic resonance imaging scanners from September 1, 1998 to July 7, 2004. No SynchroMed EL pumps were damaged by magnetic resonance imaging, and the programmable settings remained unchanged in all patients. Our data suggest that SynchroMed EL pump malfunction is indeed rare after routine clinical 1.5-T magnetic resonance imaging examinations. However, based on the Medtronic correction report, we perform pump interrogation before and after imaging. (orig.)

MedHySol: Future federator project of massive production of solar hydrogen

Energy Technology Data Exchange (ETDEWEB)

Mahmah, Bouziane; Harouadi, Farid; Chader, Samira; Belhamel, Maiouf; M' Raoui, Abdelhamid; Abdeladim, Kamel [CDER, BP 62, Route de l' Observatoire, Bouzareah, Alger (Algeria); Benmoussa, H. [LESEI, Universite de Batna, Batna (Algeria); Cherigui, Adel Nasser [Universite Joseph Fourier Grenoble I, BP 87, Saint-Martin-D' Heres 38400 (France); Etievant, Claude [CETH, Innov' valley Entreprises, 91460 Marcoussis (France)

2009-06-15

Mediterranean Hydrogen Solar (MedHySol) is a federator project for development of a massive hydrogen production starting from solar energy and its exportation within a framework of a Euro-Maghrebian Cooperation project for industrial and energetic needs in the Mediterranean basin. The proposal of this project is included in the Algiers Declaration's on Hydrogen from Renewable Origin following the organization of the first international workshop on hydrogen which was held in 2005. Algeria is the privileged site to receive the MedHySol platform. The objective of the first step of the project is to realize a technological platform allowing the evaluation of emergent technologies of hydrogen production from solar energy with a significant size (10-100 kW) and to maintain the development of energetic rupture technologies. The second step of the project is to implement the most effective and less expensive technologies to pilot great projects (1-1000 MW). In this article we present the potentialities and the feasibility of MedHySol, as well as the fundamental elements for a scientific and technical supervision of this great project. (author)

Cancer beliefs in cancer survivors, cancer relatives and persons with no cancer experience

DEFF Research Database (Denmark)

Pedersen, Anette Fischer; Vedsted, Peter

2017-01-01

Forestillinger om kræft ser ud til at være forbundet med erfaringerne med kræft, viser denne artikel, som bygger på telefoninterviews med 2992 tilfældigt udvalgte danskere over 30 år. Deltagerne blev bl.a. spurgt om, hvorvidt de var enige eller uenige i forskellige forestillinger om kræft: Er kræ...

Nature-based experiences and health of cancer survivors.

Science.gov (United States)

Ray, Heather; Jakubec, Sonya L

2014-11-01

Although exposure to, and interaction with, natural environments are recognized as health-promoting, little is understood about the use of nature contact in treatment and rehabilitation for cancer survivors. This narrative review summarizes the literature exploring the influence of nature-based experiences on survivor health. Key databases included CINAHL, EMBASE, Medline, Web of Science, PubMed, PsycArticles, ProQuest, and Cancerlit databases. Sixteen articles met inclusion criteria and were reviewed. Four major categories emerged: 1) Dragon boat racing may enhance breast cancer survivor quality of life, 2) Natural environment may counteract attentional fatigue in newly diagnosed breast cancer survivors, 3) Adventure programs provide a positive experience for children and adolescent survivors, fostering a sense of belonging and self-esteem, and 4) Therapeutic landscapes may decrease state-anxiety, improving survivor health. This review contributes to a better understanding of the therapeutic effects of nature-based experiences on cancer survivor health, providing a point of entry for future study. Copyright © 2014 Elsevier Ltd. All rights reserved.

Protocol for a systematic review of psychological interventions for cancer-related fatigue in post-treatment cancer survivors.

Science.gov (United States)

Corbett, Teresa; Devane, Declan; Walsh, Jane C; Groarke, AnnMarie; McGuire, Brian E

2015-12-04

Fatigue is a common symptom in cancer patients that can persist beyond the curative treatment phase. Some evidence has been reported for interventions for fatigue during active treatment. However, to date, there is no systematic review on psychological interventions for fatigue after the completion of curative treatment for cancer. This is a protocol for a systematic review that aims to evaluate the effectiveness of psychological interventions for cancer-related fatigue in post-treatment cancer survivors. This systematic review protocol was registered with the International Prospective Register of Systematic Reviews (PROSPERO) database. We will search the Cochrane Central Register of Controlled Trials (CENTRAL; The Cochrane Library), PubMed, MEDLINE, EMBASE, CINAHL, PsycINFO, and relevant sources of grey literature. Randomised controlled trials (RCTs) which have evaluated psychological interventions in adult cancer patients after the completion of treatment, with fatigue as an outcome measure, will be included. Two review authors will independently extract data from the selected studies and assess the methodological quality using the Cochrane Collaboration Risk of Bias Tool. Most existing evidence on cancer-related fatigue is from those in active cancer treatment. This systematic review and meta-analysis will build upon previous evaluations of psychological interventions in people during and after cancer treatment. With the growing need for stage-specific research in cancer, this review seeks to highlight a gap in current practice and to strengthen the evidence base of randomised controlled trials in the area. PROSPERO CRD42014015219.

Live-innspilling i studio med fokus på akustisk gitar og vokal

OpenAIRE

Lamborg, Kristine; Larsen, Axel Wold

2014-01-01

vår bacheloroppgave foreligger det en teoretisk undersøkelse, samt tre live-innspillinger med artisten Robert Bergstrøm. Vårt mål, i tillegg til å spille inn disse låtene, var å undersøke hvilke faktorer som kunne være med på å påvirke en live-innspilling i studio. Vi kom frem til at små detaljer som for eksempel valg av plekter, justering av mikrofonplassering og slitasje på stemmebåndet kan påvirke en produksjon i stor grad. Videre kom vi frem til at kondensatormikrofoner tilfører et rik...

Use of scientific social networking to improve the research strategies of PubMed readers

OpenAIRE

Evdokimov, Pavel; Kudryavtsev, Alexey; Ilgisonis, Ekaterina; Ponomarenko, Elena; Lisitsa, Andrey

2016-01-01

Background Keeping up with journal articles on a daily basis is an important activity of scientists engaged in biomedical research. Usually, journal articles and papers in the field of biomedicine are accessed through the Medline/PubMed electronic library. In the process of navigating PubMed, researchers unknowingly generate user-specific reading profiles that can be shared within a social networking environment. This paper examines the structure of the social networking environment generated...

Reconstitution of active human core Mediator complex reveals a pivotal role of the MED14 subunit

Science.gov (United States)

Cevher, Murat A.; Shi, Yi; Li, Dan; Chait, Brian T.; Malik, Sohail; Roeder, Robert G.

2014-01-01

The evolutionarily conserved Mediator complex is a critical coactivator for RNA polymerase II (Pol II)-mediated transcription. Here, we report the reconstitution of a functional 15-subunit human core Mediator complex and its characterization by functional assays and chemical cross-linking coupled to mass spectrometry (CX-MS). Whereas the reconstituted head and middle modules can stably associate, only with incorporation of MED14 into the bi-modular complex does it acquire basal and coactivator functions. This results from a dramatically enhanced ability of MED14-containing complexes to associate with Pol II. Altogether, our analyses identify MED14 as both an architectural and a functional backbone of the Mediator complex. We further establish a conditional requirement for metazoan-specific MED26 that becomes evident in the presence of heterologous nuclear factors. This general approach paves the way for systematically dissecting the multiple layers of functionalities associated with the Mediator complex. PMID:25383669

Coffee Consumption and Risk of Biliary Tract Cancers and Liver Cancer: A Dose-Response Meta-Analysis of Prospective Cohort Studies.

Science.gov (United States)

Godos, Justyna; Micek, Agnieszka; Marranzano, Marina; Salomone, Federico; Rio, Daniele Del; Ray, Sumantra

2017-08-28

A meta-analysis was conducted to summarize the evidence from prospective cohort and case-control studies regarding the association between coffee intake and biliary tract cancer (BTC) and liver cancer risk. Eligible studies were identified by searches of PubMed and EMBASE databases from the earliest available online indexing year to March 2017. The dose-response relationship was assessed by a restricted cubic spline model and multivariate random-effect meta-regression. A stratified and subgroup analysis by smoking status and hepatitis was performed to identify potential confounding factors. We identified five studies on BTC risk and 13 on liver cancer risk eligible for meta-analysis. A linear dose-response meta-analysis did not show a significant association between coffee consumption and BTC risk. However, there was evidence of inverse correlation between coffee consumption and liver cancer risk. The association was consistent throughout the various potential confounding factors explored including smoking status, hepatitis, etc. Increasing coffee consumption by one cup per day was associated with a 15% reduction in liver cancer risk (RR 0.85; 95% CI 0.82 to 0.88). The findings suggest that increased coffee consumption is associated with decreased risk of liver cancer, but not BTC.

Hvem er mest fornøyd med samlivet? : samlivskvalitet blant samboere og gifte

OpenAIRE

Wiik, Kenneth Aarskaug; Noack, Turid

2011-01-01

Artiklene i Samfunnsspeilet er tilgjengelige fra SSBs nettsider: http://www.ssb.no/ssp/ Norge og Sverige er land der samboerskap har en lang historie, og der denne samlivsformen er mest utbredt. I dag er et av fire samliv her til lands samboerskap. Men også her er det forskjeller mellom samboere og gifte. Hvis vi sammenlikner samlivskvaliteten blant samboere og gifte, finner vi at unge samboere i alderen 25 til 35 år er minst fornøyd med samlivet sitt. Samboere med planer om å gifte seg me...

Cancer incidence among copper smelting and nickel refining workers in Finland.

Science.gov (United States)

Pavela, Markku; Uitti, Jukka; Pukkala, Eero

2017-01-01

Among workers employed at a nickel refinery in Harjavalta, Finland an increased risk of lung and sinus cancer has been demonstrated in two previous studies. The current study adds 16 more years of follow-up to these studies. A total of 1,115 persons exposed to nickel and 194 non-exposed workers in the Harjavalta nickel smelter and refinery were followed up for cancer from 1967 to 2011 through the Finnish Cancer Registry. The total number of cancer cases in men was 251 (Standardized incidence ratio (SIR) 1.05) and in women 12 (SIR 1.22). In the most nickel-exposed work site (refinery), there were 14 lung cancers (SIR 2.01) and 3 sinonasal cancers (SIR 26.7, 95%). It is likely that exposure to nickel compounds is the main reason for elevated nasal cancer risk among the nickel refinery employees and may also contribute to the excess risk of lung cancer. Am. J. Ind. Med. 60:87-95, 2017. © 2016 Wiley Periodicals, Inc. © 2016 Wiley Periodicals, Inc.

Genotypic distribution of single nucleotide polymorphisms in oral cancer: global scene.

Science.gov (United States)

Multani, Shaleen; Saranath, Dhananjaya

2016-11-01

Globocan 2012 reports the global oral cancer incidence of 300,373 new oral cancer cases annually, contributing to 2.1 % of the world cancer burden. The major well-established risk factors for oral cancer include tobacco, betel/areca nut, alcohol and high-risk oncogenic human papilloma virus (HPV) 16/18. However, only 5-10 % of individuals with high-risk lifestyle develop oral cancer. Thus, genomic variants in individuals represented as single nucleotide polymorphisms (SNPs) influence susceptibility to oral cancer. With a view to understanding the role of genomic variants in oral cancer, we reviewed SNPs in case-control studies with a minimum of 100 cases and 100 controls. PubMed and HuGE navigator search engines were used to obtain data published from 1990 to 2015, which identified 67 articles investigating the role of SNPs in oral cancer. Single publications reported 93 SNPs in 55 genes, with 34 SNPs associated with a risk of oral cancer. Meta-analysis of data in multiple studies defined nine SNPs associated with a risk of oral cancer. The genes were associated with critical functions deregulated in cancers, including cell proliferation, immune function, inflammation, transcription, DNA repair and xenobiotic metabolism.

Miljøoptimering af afvaskning ved tryk med vandfortyndbar flexotrykfarve

DEFF Research Database (Denmark)

Larsen, Henrik Fred; Helweg, Christian; Pedersen, Anne Rathmann

Rapporten beskriver praksis ved afvaskning af vandfortyndbare flexotrykfarver i emballageindustrien og anviser muligheder for indførelse af renere teknologi til reduktion af spildevandsbelastningen. Anbefalingerne omfatter a) udformning af farveværker med henblik på effektiv tømning af farve og e...

Narrativ kostvejledning - en ny tilgang til diætisten, der styrker relationsdannelse og samarbejde med borgeren

DEFF Research Database (Denmark)

Kristensen, Søren Tange

2017-01-01

I Oplægget præsenteres hovedresultater fra en artikel indsendt til tidsskriftet Topics in Clinical Nutrition1, der undersøger hvordan Narrativ kostvejledning (NK) kan styrke diætisters relationsdannelse og samarbejde med borgere med kroniske lidelser. Artiklen bygger på data indsamlet i forbindelse...

The Tlo Proteins Are Stoichiometric Components of Candida albicans Mediator Anchored via the Med3 Subunit

Science.gov (United States)

Zhang, Anda; Petrov, Kostadin O.; Hyun, Emily R.; Liu, Zhongle; Gerber, Scott A.

2012-01-01

The amplification of the TLO (for telomere-associated) genes in Candida albicans, compared to its less pathogenic, close relative Candida dubliniensis, suggests a role in virulence. Little, however, is known about the function of the Tlo proteins. We have purified the Mediator coactivator complex from C. albicans (caMediator) and found that Tlo proteins are a stoichiometric component of caMediator. Many members of the Tlo family are expressed, and each is a unique member of caMediator. Protein expression analysis of individual Tlo proteins, as well as the purification of tagged Tlo proteins, demonstrate that there is a large free population of Tlo proteins in addition to the Mediator-associated population. Coexpression and copurification of Tloα12 and caMed3 in Escherichia coli established a direct physical interaction between the two proteins. We have also made a C. albicans med3Δ/Δ strain and purified an intact Mediator from this strain. The analysis of the composition of the med3Δ Mediator shows that it lacks a Tlo subunit. Regarding Mediator function, the med3Δ/Δ strain serves as a substitute for the difficult-to-make tloΔ/Δ C. albicans strain. A potential role of the TLO and MED3 genes in virulence is supported by the inability of the med3Δ/Δ strain to form normal germ tubes. This study of caMediator structure provides initial clues to the mechanism of action of the Tlo genes and a platform for further mechanistic studies of caMediator's involvement in gene regulatory patterns that underlie pathogenesis. PMID:22562472

Interventions to improve recall of medical information in cancer patients: a systematic review of the literature.

NARCIS (Netherlands)

Meulen, N. van der; Jansen, J.; Dulmen, S. van; Bensing, J.; Weert, J. van

2008-01-01

This systematic review investigates which interventions are effective to improve recall of medical information in cancer patients. A literature research was done in PubMed, PsychINFO, CINAHL and Cochrane Library, following the guidelines of the Cochrane Collaboration. The methodological quality of

Physical activity influences the immune system of breast cancer patients

Directory of Open Access Journals (Sweden)

Thorsten Schmidt

2017-01-01

Full Text Available It has been suggested that physical activity in breast cancer patients can not only improve quality of life. Influences on physical and psychological levels have been evaluated, but effects on the immune system of breast cancer patients are hardly known. A PubMed search identified relevant trials and meta-analyses from 1970 to 2013. This review summarizes the results of international studies and the current discussion of effects of physical activity on the immune system of breast cancer patients. Highlighted are effects of physical activity on the immune system. Seven original articles and 14 reviews included in this review. Two original and the review articles includes other tumor entities besides breast cancer.Evaluated methods such as dose-response relationships for exercise in oncology, hardly exist. Increased immunological anti-cancer activity due to physical activity is probably mediated via an increase in number and cytotoxicity of monocytes and natural killer cells and cytokines.

PET-CT and PET-MR in urological cancers other than prostate cancer: An update on state of the art.

Science.gov (United States)

Razik, Abdul; Das, Chandan Jyoti; Sharma, Sanjay

2018-01-01

Hybrid positron emission tomography with computed tomography (PET/CT) and magnetic resonance imaging (PET/MRI) have enabled the combination of morphologic and functional imaging with the promise of providing better information in guiding therapy. Further advance has been made in the past decade with the development of newer radiotracers and optimization of the technical aspects. We performed a search in PubMed, Scopus, and Google Scholar for peer-reviewed literature concerning the advances and newer developments in the imaging of nonprostate urologic cancers between 2005 and 2017. This review aims at summarizing the current evidence on PET imaging in nonprostate urologic cancers and their impact on the diagnosis, staging, prognostication, response assessment, and restaging of these malignancies. However, much of the evidence is still in infancy and has not been incorporated into routine management or the practice guidelines of National Comprehensive Cancer Network or European Society for Medical Oncology (ESMO).

Post-Traumatic Growth and Resilience in Adolescent and Young Adult Cancer Patients: An Overview

NARCIS (Netherlands)

Greup, Suzanne R.; Kaal, Suzanne E. J.; Jansen, Rosemarie; Manten-Horst, Eveliene; Thong, Melissa S. Y.; van der Graaf, Winette T. A.; Prins, Judith B.; Husson, Olga

2018-01-01

The aim of this study was to provide an overview of the literature on post-traumatic growth (PTG) and resilience among adolescent and young adult (AYA) cancer patients. A literature search in Embase, PsychInfo, PubMed, Web of Science, Cochrane Library, and Cinahl was carried out. Thirteen articles

Att drabbas av cancer i tonåren : En kvantitativ studie om hälsorelaterad livskvalitet två till fyra år efter diagnos

OpenAIRE

Hiding, Markus; Lavemark, Niklas

2010-01-01

Syfte Studiens syfte var att undersöka: självskattad hälsorelaterad livskvalitet hos tonåringar som drabbats av cancer två år (T5), tre år (T6) och fyra år (T7) efter diagnos, samt att jämföra deras skattningar med en referensgrupp randomiserad från befolkningen.   Metod Tonåringarna med cancer besvarade SF-36 2 år (N=38), 3 år (N=42) samt 4 år (N=39) efter diagnos. En referensgrupp (N=300) randomiserad av Statistiska centralbyrån (SCB) besvarade samma formulär vid ett tillfälle. Samtlig data...

Græsensilage med forskellig snitlængde til drægtige og diegivende moderfår

DEFF Research Database (Denmark)

Eilersen, Rie Jasmund; Arnesson, Annika; Nadeau, Elisabet

2009-01-01

Forsøget viste, at får med tvilling lam der gives 0,8 kg kraftfoder pr dag, under diegivningen æder 1,5 gange mere ensilage end under drægtigheden. Snitning af ensilagen til en partikellængde på 1,3 cm medførte ikke højere optagelse af ensilage ved separat fodring. Når ensilage med denne snitlængde...... indgik i fuldfoder havde fårene en 12% større daglig foderoptagelse efter læmning sammenlignet med separat fodertildeling....

Bedre trafikuheldsdata: Danske erfaringer med brug af forskellige typer trafikuheldsdata

DEFF Research Database (Denmark)

Møller, Mette; Clemmensen, Mikkel Bøg; Janstrup, Kira Hyldekær

bidraget til kvalitetssikring af projektets forskellige dele, og seniorforsker Mette Møller har været overordnet projektansvarlig. Stud. BEng Lars Finn Jensen og stud. BEng Niels Klindt Andersen har varetaget dataindsamling i forbindelse med rundspørgen blandt kommunerne. Vi vil gerne udtrykke en stor tak...