WorldWideScience

Sample records for meaningful parameter values

  1. Beyond meaningful use: getting meaningful value from IT.

    Science.gov (United States)

    Fortin, Jason; Zywiak, Walt

    2010-02-01

    The HITECH provisions of ARRA include financial incentives for providers to demonstrate meaningful use of certified EHR technology. However, to maximize the value of IT under new payment models, provider organizations will need to go beyond meaningful use criteria in three key areas: Delivering high-quality care. Ensuring coordinated care. Integrating financial systems.

  2. Types of Meaningfulness of Life and Values of Future Teachers

    Science.gov (United States)

    Salikhova, Nailia R.

    2016-01-01

    The leading role of meaning of life in regulation of human's activity of all types provides the relevance of the research. The goal of the paper is to identify and describe types of meaningfulness of life in future teachers, and to reveal the specificity of values hierarchy indicative of each type. The leading approach applied in the research was…

  3. Intrinsic Value and a Meaningful Life | Audi | Philosophical Papers

    African Journals Online (AJOL)

    I distinguish various ways in which human life may be thought to be meaningful and present an account of what might be called existential meaningfulness. The account is neutral with respect to both theism and naturalism, but each is addressed in several places and the paper's main points are harmonious with certain ...

  4. THE VALUE OF THE PROJECT, ITS HISTORICAL CONTEXT AND MEANINGFUL

    Directory of Open Access Journals (Sweden)

    Anastasiia Liezina

    2017-03-01

    Full Text Available In the article the historical stages of the category of “value” in various sciences, particularly in project management were considered. Chronology of evolutionary change and borrowing the term “value” in various sciences was developed. Existing approaches to determining the value of project management were analyzed. Author's interpretation of value projects was represented. Author's vision “iron” triangle of project management criteria based on the transformation of the classical approach was represented. Substance of the value of projects, taking into account the interests of all stakeholders, in terms of their value expectations was revealed. Key words: value, project management, project value, project stakeholders, the criteria for success of the project, “Iron” triangle.

  5. Values-led Participatory Design as a pursuit of meaningful alternatives

    DEFF Research Database (Denmark)

    Leong, Tuck Wah; Iversen, Ole Sejer

    2015-01-01

    Participatory Design (PD) is inherently concerned with inquiring into and supporting human values when designing IT. We argue that a PD approach that is led by a focus upon participants' values can allow participants to discover meaningful alternatives -- alternative uses and alternative...... conceptualizations for IT that are particularly meaningful to them. However, how PD works with values in the design process has not been made explicit. In this paper, we aim to (i) explicate this values-led PD approach, (ii) illustrate how this approach can lead to outcomes that are meaningful alternatives, and (iii...

  6. The Meaningful Activity Participation Assessment: A Measure of Engagement in Personally Valued Activities

    Science.gov (United States)

    Eakman, Aaron M.; Carlson, Mike E.; Clark, Florence A.

    2010-01-01

    The Meaningful Activity Participation Assessment (MAPA), a recently developed 28-item tool designed to measure the meaningfulness of activity, was tested in a sample of 154 older adults. The MAPA evidenced a sufficient level of internal consistency and test-retest reliability and correlated as theoretically predicted with the Life Satisfaction…

  7. THE MEANINGFUL ACTIVITY PARTICIPATION ASSESSMENT: A MEASURE OF ENGAGEMENT IN PERSONALLY VALUED ACTIVITIES*

    Science.gov (United States)

    EAKMAN, AARON M.; CARLSON, MIKE E.; CLARK, FLORENCE A.

    2011-01-01

    The Meaningful Activity Participation Assessment (MAPA), a recently developed 28-item tool designed to measure the meaningfulness of activity, was tested in a sample of 154 older adults. The MAPA evidenced a sufficient level of internal consistency and test-retest reliability and correlated as theoretically predicted with the Life Satisfaction Index-Z, the Satisfaction with Life Scale, the Engagement in Meaningful Activities Survey, the Purpose in Life Test, the Center for Epidemiologic Studies Depression Inventory and the Rand SF-36v2 Health Survey subscales. Zero-order correlations consistently demonstrated meaningful relationships between the MAPA and scales of psychosocial well-being and health-related quality of life. Results from multiple regression analyses further substantiated these findings, as greater meaningful activity participation was associated with better psychological well-being and health-related quality of life. The MAPA appears to be a reliable and valid measure of meaningful activity, incorporating both subjective and objective indicators of activity engagement. PMID:20649161

  8. CONCEPTUAL APPROACHES TO THE EDUCATION OF LIFE-MEANINGFUL VALUES OF TEENAGERS AND EARLY ADOLESCENCE IN UKRAINE

    Directory of Open Access Journals (Sweden)

    Katherinа Zhurba

    2015-04-01

    Full Text Available The article presents the conceptual approaches to the upbringing in the education of life-meaningful values of teenagers and early adolescence in Ukraine. The definition of life-meaningful values has been given up. The major problems and contradictions in the upbringing of the Ukrainian children were paid attention to. The dependence of the result of upbringing, from the desire and the participation of all actors: children, parents, teachers is pointed out. Conceptual approaches to education of life values meaning are analyzed on the methodological, theoretical and practical levels. The aspects of the previous researches have been underlined. In this context, a systematic approach determines the integrity of the educational process in primary and high school. Synergetic approach combines the organization and self-organization of the growing personality. Humanistic approach recognizes each child's highest value at school, family, and society. Personal-centered approach provides individual attention to him, to free choice of that or other life-meaningful values. Activity approach provides practice and deed activity of children and shows how the value of the meaning of life affects the behavior of the individual. The theoretical level of substantiation of the concept of education of children of teenagers and early youth gives ability to define key points and concepts. Practical level implies the corresponding experimental activity, the determination of propriate pedagogical conditions, the selection of content, forms and methods of education of teenagers and early adolescence. Conceptual approaches offer the opportunity to develop a modern system of education of the values of the meaning of life of teenagers and early adolescence in Ukraine. Implementation of conceptual approaches aimed at qualitative changes in the education of life-meaningful values among of teenagers and early adolescence.

  9. Identifying clinically meaningful symptom response cut-off values on the SANS in predominant negative symptoms.

    Science.gov (United States)

    Levine, Stephen Z; Leucht, Stefan

    2013-04-01

    The treatment and measurement of negative symptoms are currently at issue in schizophrenia, but the clinical meaning of symptom severity and change is unclear. To offer a clinically meaningful interpretation of severity and change scores on the Scale for the Assessment of Negative Symptoms (SANS). Patients were intention-to-treat participants (n=383) in two double-blind randomized placebo-controlled clinical trials that compared amisulpride with placebo for the treatment of predominant negative symptoms. Equipercentile linking was used to examine extrapolation from (a) CGI-S to SANS severity ratings, and (b) CGI-I to SANS percentage change (n=383). Linking was conducted at baseline, 8-14 days, 28-30 days, and 56-60 days of the trials. Across visits, CGI-S ratings of 'not ill' linked to SANS scores of 0-13, and ranged to 'extreme' ratings that linked to SANS scores of 102-105. The relationship between the CGI-S and the SANS severity scores assumed a linear trend (1=0-13, 2=15-56, 3=37-61, 4=49-66, 5=63-75, 6=79-89, 7=102-105). Similarly the relationship between CGI-I ratings and SANS percentage change followed a linear trend. For instance, CGI-I ratings of 'very much improved' were linked to SANS percent changes of -90 to -67, 'much improved' to -50 to -42, and 'minimally improved' to -21 to -13. The current results uniquely contribute to the debate surrounding negative symptoms by providing clinical meaning to SANS severity and change scores and so offer direction regarding clinically meaningful response cut-off scores to guide treatment targets of predominant negative symptoms. Copyright © 2013 Elsevier B.V. All rights reserved.

  10. Mapping Meaningful Places on Washington's Olympic Peninsula: Toward a Deeper Understanding of Landscape Values.

    Science.gov (United States)

    Cerveny, Lee Karol; Biedenweg, Kelly; McLain, Rebecca

    2017-10-01

    Landscape values mapping has been widely employed as a form of public participation GIS (PPGIS) in natural resource planning and decision-making to capture the complex array of values, uses, and interactions between people and landscapes. A landscape values typology has been commonly employed in the mapping of social and environmental values in a variety of management settings and scales. We explore how people attribute meanings and assign values to special places on the Olympic Peninsula (Washington, USA) using both a landscape values typology and qualitative responses about residents' place-relationships. Using geographically referenced social values data collected in community meetings (n = 169), we identify high-frequency landscape values and examine how well the landscape values are reflected in open-ended descriptions of place-relations. We also explore the various interpretations of 14 landscape values used in the study. In particular, we investigate any overlapping meanings or blurriness among landscape values and reveal potentially emergent landscape values from the qualitative data. The results provide insights on the use of landscape values mapping typologies for practitioners and researchers engaged in the mapping of social values for PPGIS.

  11. Mapping Meaningful Places on Washington's Olympic Peninsula: Toward a Deeper Understanding of Landscape Values

    Science.gov (United States)

    Cerveny, Lee Karol; Biedenweg, Kelly; McLain, Rebecca

    2017-10-01

    Landscape values mapping has been widely employed as a form of public participation GIS (PPGIS) in natural resource planning and decision-making to capture the complex array of values, uses, and interactions between people and landscapes. A landscape values typology has been commonly employed in the mapping of social and environmental values in a variety of management settings and scales. We explore how people attribute meanings and assign values to special places on the Olympic Peninsula (Washington, USA) using both a landscape values typology and qualitative responses about residents' place-relationships. Using geographically referenced social values data collected in community meetings ( n = 169), we identify high-frequency landscape values and examine how well the landscape values are reflected in open-ended descriptions of place-relations. We also explore the various interpretations of 14 landscape values used in the study. In particular, we investigate any overlapping meanings or blurriness among landscape values and reveal potentially emergent landscape values from the qualitative data. The results provide insights on the use of landscape values mapping typologies for practitioners and researchers engaged in the mapping of social values for PPGIS.

  12. A novel validation algorithm allows for automated cell tracking and the extraction of biologically meaningful parameters.

    Directory of Open Access Journals (Sweden)

    Daniel H Rapoport

    Full Text Available Automated microscopy is currently the only method to non-invasively and label-free observe complex multi-cellular processes, such as cell migration, cell cycle, and cell differentiation. Extracting biological information from a time-series of micrographs requires each cell to be recognized and followed through sequential microscopic snapshots. Although recent attempts to automatize this process resulted in ever improving cell detection rates, manual identification of identical cells is still the most reliable technique. However, its tedious and subjective nature prevented tracking from becoming a standardized tool for the investigation of cell cultures. Here, we present a novel method to accomplish automated cell tracking with a reliability comparable to manual tracking. Previously, automated cell tracking could not rival the reliability of manual tracking because, in contrast to the human way of solving this task, none of the algorithms had an independent quality control mechanism; they missed validation. Thus, instead of trying to improve the cell detection or tracking rates, we proceeded from the idea to automatically inspect the tracking results and accept only those of high trustworthiness, while rejecting all other results. This validation algorithm works independently of the quality of cell detection and tracking through a systematic search for tracking errors. It is based only on very general assumptions about the spatiotemporal contiguity of cell paths. While traditional tracking often aims to yield genealogic information about single cells, the natural outcome of a validated cell tracking algorithm turns out to be a set of complete, but often unconnected cell paths, i.e. records of cells from mitosis to mitosis. This is a consequence of the fact that the validation algorithm takes complete paths as the unit of rejection/acceptance. The resulting set of complete paths can be used to automatically extract important biological parameters

  13. DEVELOPMENT OF VADOSE ZONE HYDRAULIC PARAMETER VALUES

    International Nuclear Information System (INIS)

    ROGERS PM

    2008-01-01

    Several approaches have been developed to establish a relation between the soil-moisture retention curve and readily available soil properties. Those relationships are referred to as pedotransfer functions. Described in this paper are the rationale, approach, and corroboration for use of a nonparametric pedotransfer function for the estimation of soil hydraulic-parameter values at the yucca Mountain area in Nevada for simulations of net infiltration. This approach, shown to be applicable for use at Yucca Mountain, is also applicable for use at the Hanford Site where the underlying data were collected

  14. Models for setting ATM parameter values

    DEFF Research Database (Denmark)

    Blaabjerg, Søren; Gravey, A.; Romæuf, L.

    1996-01-01

    essential to set traffic characteristic values that are relevant to the considered cell stream, and that ensure that the amount of non-conforming traffic is small. Using a queueing model representation for the GCRA formalism, several methods are available for choosing the traffic characteristics. This paper......In ATM networks, a user should negotiate at connection set-up a traffic contract which includes traffic characteristics and requested QoS. The traffic characteristics currently considered are the Peak Cell Rate, the Sustainable Cell Rate, the Intrinsic Burst Tolerance and the Cell Delay Variation...... (CDV) tolerance(s). The values taken by these traffic parameters characterize the so-called ''Worst Case Traffic'' that is used by CAC procedures for accepting a new connection and allocating resources to it. Conformance to the negotiated traffic characteristics is defined, at the ingress User...

  15. Business intelligence effort get a boost. The meaningful use framework highlights the value of data warehouses and BI tools.

    Science.gov (United States)

    Raths, David

    2011-01-01

    As patient care organizations nationwide prepare to report on meaningful use quality measures, those with enterprise data warehouses may find they have a head start. The more advanced among them are establishing workgroups to create dashboards to analyze progress and identify gaps that need addressing.

  16. Heard and valued: the development of a model to meaningfully engage marginalized populations in health services planning.

    Science.gov (United States)

    Snow, M Elizabeth; Tweedie, Katherine; Pederson, Ann

    2018-03-15

    Recently, patient engagement has been identified as a promising strategy for supporting healthcare planning. However, the context and structure of universalistic, "one-size-fits-all" approaches often used for patient engagement may not enable diverse patients to participate in decision-making about programs intended to meet their needs. Specifically, standard patient engagement approaches are gender-blind and might not facilitate the engagement of those marginalized by, for example, substance use, low income, experiences of violence, homelessness, and/or mental health challenges-highly gendered health and social experiences. The project's purpose was to develop a heuristic model to assist planners to engage patients who are not traditionally included in healthcare planning. Using a qualitative research approach, we reviewed literature and conducted interviews with patients and healthcare planners regarding engaging marginalized populations in health services planning. From these inputs, we created a model and planning manual to assist healthcare planners to engage marginalized patients in health services planning, which we piloted in two clinical programs undergoing health services design. The findings from the pilots were used to refine the model. The analysis of the interviews and literature identified power and gender as barriers to participation, and generated suggestions to support diverse populations both to attend patient engagement events and to participate meaningfully. Engaging marginalized populations cannot be reduced to a single defined process, but instead needs to be understood as an iterative process of fitting engagement methods to a particular situation. Underlying this process are principles for meaningfully engaging marginalized people in healthcare planning. A one-size-fits-all approach to patient engagement is not appropriate given patients' diverse barriers to meaningful participation in healthcare planning. Instead, planners need a

  17. Analysis of Camera Parameters Value in Various Object Distances Calibration

    International Nuclear Information System (INIS)

    Yusoff, Ahmad Razali; Ariff, Mohd Farid Mohd; Idris, Khairulnizam M; Majid, Zulkepli; Setan, Halim; Chong, Albert K

    2014-01-01

    In photogrammetric applications, good camera parameters are needed for mapping purpose such as an Unmanned Aerial Vehicle (UAV) that encompassed with non-metric camera devices. Simple camera calibration was being a common application in many laboratory works in order to get the camera parameter's value. In aerial mapping, interior camera parameters' value from close-range camera calibration is used to correct the image error. However, the causes and effects of the calibration steps used to get accurate mapping need to be analyze. Therefore, this research aims to contribute an analysis of camera parameters from portable calibration frame of 1.5 × 1 meter dimension size. Object distances of two, three, four, five, and six meters are the research focus. Results are analyzed to find out the changes in image and camera parameters' value. Hence, camera calibration parameter's of a camera is consider different depend on type of calibration parameters and object distances

  18. ECOS: values of parameters to be used for domestic animals

    International Nuclear Information System (INIS)

    Thorne, M.C.

    1984-03-01

    This report constitutes the database description for the domestic animals section of the biosphere code ECOS. Two categories of data are supplied, element-independent and element-dependent. The element-independent data comprise rates of food, water and soil consumption, inhalation rates and masses of animal tissues. The element-dependent data consist of f 1 (fractional gastrointestinal absorption), fsub(D) (fractional systematic deposition after inhalation) and NRF (weighted integrated retention function) values. All parameter values given are justified. (author)

  19. Correlating substituent parameter values to electron transport properties of molecules

    International Nuclear Information System (INIS)

    Vedova-Brook, Natalie; Matsunaga, Nikita; Sohlberg, Karl

    2004-01-01

    There are a vast number of organic compounds that could be considered for use in molecular electronics. Because of this, the need for efficient and economical screening tools has emerged. We demonstrate that the substituent parameter values (σ), commonly found in advanced organic chemistry textbooks, correlate strongly with features of the charge migration process, establishing them as useful indicators of electronic properties. Specifically, we report that ab initio derived electronic charge transfer values for 16 different substituted aromatic molecules for molecular junctions correlate to the σ values with a correlation coefficient squared (R 2 ) of 0.863

  20. Use of cut-off values as meaningfulness limits in probabilistic studies and its effect on NPPs risk assessment and safety improvement

    International Nuclear Information System (INIS)

    Petrangeli, G.; Valeri, A.; Zaffiro, C.

    1991-01-01

    This paper discusses the use of cut-off values in probabilistic risk assessment/probabilistic safety assessment (PRA/PSA) of nuclear power plants (NPPs), in order to explore under which conditions this practice may help improve the meaningfulness of the results of the analyses and safety of plants, and how it may affect the assessment of risk. Reference is made, in particular, to some past practical applications, also taken from the experience of the authors within the frame of the Italian licensing process. The paper describes the Italian probabilistic criteria which use probabilistic targets and cut-off values to assess safety and identify plant safety improvements. The rationale of the approach is also discussed in the paper and results of sample applications are illustrated. The paper concludes that the use of cut-off values, if properly implemented, could be productive to improve the plant safety as it helps the analyst to focus on a restricted field of analysis, ignoring lower probability and less known events. It also points out that cut-off values should be considered as living numbers to be lowered and even eliminated as soon as significant advancements are made, through research and operational experience, in the knowledge of the pertinent events

  1. Diagnostic value of hematological parameters in patients with osteoarthritis

    Directory of Open Access Journals (Sweden)

    Serdar Hira

    2017-03-01

    Results: There were no significant differences in WBC, RDW, PLT, RPR levels between two groups. NLR and PLR values were significantly higher in the osteoarthritis group than in the control group. RBC, MPV and PDW values were significantly lower in the osteoarthritis group than in the control group (all . MPV and RBC were negatively correlated with ESR and CRP in osteoarthritis patients. Conclusion: Hematological inflammatory markers might be useful parameters that could be used in patients with osteoarthritis. [Cukurova Med J 2017; 42(1.000: 120-125

  2. Polychronakos fractional statistics with a complex-valued parameter

    International Nuclear Information System (INIS)

    Rovenchak, Andrij

    2012-01-01

    A generalization of quantum statistics is proposed in a fashion similar to the suggestion of Polychronakos [Phys. Lett. B 365, 202 (1996)] with the parameter α varying between −1 (fermionic case) and +1 (bosonic case). However, unlike the original formulation, it is suggested that intermediate values are located on the unit circle in the complex plane. In doing so one can avoid the case α = 0 corresponding to the Boltzmann statistics, which is not a quantum one. The limits of α → +1 and α → −1 reproducing small deviations from the Bose and Fermi statistics, respectively, are studied in detail. The equivalence between the statistics parameter and a possible dissipative part of the excitation spectrum is established. The case of a non-conserving number of excitations is analyzed. It is defined from the condition that the real part of the chemical potential equals zero. Thermodynamic quantities of a model system of two-dimensional harmonic oscillators are calculated.

  3. DEVELOPMENT OF VADOSE-ZONE HYDRAULIC PARAMETER VALUES

    Energy Technology Data Exchange (ETDEWEB)

    ROGERS PM

    2008-01-21

    Several approaches have been developed to establish a relation between the soil-moisture retention curve and readily available soil properties. Those relationships are referred to as pedotransfer functions. Described in this paper are the rationale, approach, and corroboration for use of a nonparametric pedotransfer function for the estimation of soil hydraulic-parameter values at the yucca Mountain area in Nevada for simulations of net infiltration. This approach, shown to be applicable for use at Yucca Mountain, is also applicable for use at the Hanford Site where the underlying data were collected.

  4. Estimation of the value-at-risk parameter: Econometric analysis and the extreme value theory approach

    Directory of Open Access Journals (Sweden)

    Mladenović Zorica

    2006-01-01

    Full Text Available In this paper different aspects of value-at-risk estimation are considered. Daily returns of CISCO, INTEL and NASDAQ stock indices are analyzed for period: September 1996 - September 2006. Methods that incorporate time varying variability and heavy tails of the empirical distributions of returns are implemented. The main finding of the paper is that standard econometric methods underestimate the value-at-risk parameter if heavy tails of the empirical distribution are not explicitly taken into account. .

  5. Impact of hierarchy upon the values of neutrino mixing parameters

    International Nuclear Information System (INIS)

    Escamilla-Roa, J.; Ernst, D. J.; Latimer, D. C.

    2010-01-01

    A neutrino-oscillation analysis is performed of the more finely binned Super-Kamiokande (Super-K) atmospheric, MINOS, and CHOOZ data to examine the effect of neutrino hierarchy in this data set on the value of θ 13 and the deviation of θ 23 from maximal mixing. Exact oscillation probabilities are used, thus incorporating all powers of θ 13 and ε:=θ 23 -π/4. The extracted oscillation parameters are found to be dependent on the hierarchy, particularly for θ 13 . We find, at a 90% confidence level, that these parameters are Δ 32 =2.44 -0.20 +0.26 and 2.48 -0.22 +0.25 x10 -3 eV 2 , ε=θ 23 -π/4=0.06 -0.16 +0.06 and 0.06 -0.17 +0.08 , and θ 13 =-0.07 -0.11 +0.18 and -0.13 -0.16 +0.23 , for the normal and inverted hierarchies, respectively. The inverted hierarchy is preferred at a statistically insignificant level of 0.3σ.

  6. Are historical values of ionospheric parameters from ionosondes overestimated?

    Science.gov (United States)

    Laštovička, J.; Koucká Knížová, P.; Kouba, D.

    2012-04-01

    Ionogram-scaled values from pre-digital ionosonde times had been derived from ionograms under the assumption of the vertical reflection of ordinary mode of sounding radio waves. Classical ionosondes were unable to distinguish between the vertical and oblique reflections and in the case of the Es-layer also between the ordinary and extraordinary mode reflections due to mirror-like reflections. However, modern digisondes determine clearly the oblique or extraordinary mode reflections. Evaluating the Pruhonice digisonde ionograms in "classical" and in "correct" way we found for seven summers (2004-2010) that among strong foEs (> 6 MHz) only 10% of foEs values were correct and 90% were artificially enhanced in average by 1 MHz, in extreme cases by more than 3 MHz (some oblique reflections). 34% of all reflections were oblique reflections. With other ionospheric parameters like foF2 or foE the problem is less severe because non-mirror reflection makes delay of the extraordinary mode with respect to the ordinary mode and they are separated on ionograms, and oblique reflections are less frequent than with the patchy Es layer. At high latitudes another problem is caused by the z-mode, which is sometimes difficult to be distinguished from the ordinary mode.

  7. Transfer parameter values in temperate forest ecosystems: a review

    International Nuclear Information System (INIS)

    Calmon, Philippe; Thiry, Yves; Zibold, Gregor; Rantavaara, Aino; Fesenko, Sergei

    2009-01-01

    Compared to agricultural lands, forests are complex ecosystems as they can involve diverse plant species associations, several vegetative strata (overstorey, shrubs, herbaceous and other annual plant layer) and multi-layered soil profiles (forest floor, hemi-organic and mineral layers). A high degree of variability is thus generally observed in radionuclide transfers and redistribution patterns in contaminated forests. In the long term, the soil compartment represents the major reservoir of radionuclides which can give rise to long-term plant and hence food contamination. For practical reasons, the contamination of various specific forest products has commonly been quantified using the aggregated transfer factor (T ag in m 2 kg -1 ) which integrates various environmental parameters including soil and plant type, root distribution as well as nature and vertical distribution of the deposits. Long lasting availability of some radionuclides was shown to be the source of much higher transfer in forest ecosystems than in agricultural lands. This study aimed at reviewing the most relevant quantitative information on radionuclide transfers to forest biota including trees, understorey vegetation, mushrooms, berries and game animals. For both radiocaesium and radiostrontium in trees, the order of magnitude of mean T ag values was 10 -3 m 2 kg -1 (dry weight). Tree foliage was usually 2-12 times more contaminated than trunk wood. Maximum contamination of tree components with radiocaesium was associated with (semi-)hydromorphic areas with thick humus layers. The transfer of radionuclides to mushrooms and berries is high, in comparison with foodstuffs grown in agricultural systems. Concerning caesium uptake by mushrooms, the transfer is characterized by a very large variability of T ag , from 10 -3 to 10 1 m 2 kg -1 (dry weight). For berries, typical values are around 0.01-0.1 m 2 kg -1 (dry weight). Transfer of radioactive caesium to game animals and reindeer and the rate of

  8. Transfer parameter values in temperate forest ecosystems: a review

    Energy Technology Data Exchange (ETDEWEB)

    Calmon, Philippe [Department of Radioecology, Institute of Radioprotection and Nuclear Safety, CE Cadarache, BP 3, 13115 Saint Paul-les-Durance Cedex (France)], E-mail: philippe.calmon@irsn.fr; Thiry, Yves [Biosphere Impact Studies, Belgian Nuclear Research Center (SCK.CEN, Foundation of Public Utility), 2400 Mol (Belgium); Zibold, Gregor [Hochschule Ravensburg-Weingarten, University of Applied Sciences, 88250 Weingarten (Germany); Rantavaara, Aino [Research and Environmental Surveillance, Radiation and Nuclear Safety Authority (STUK), BP 14, FIN-00881 Helsinki (Finland); Fesenko, Sergei [International Atomic Energy Agency (IAEA), 1400 Vienna (Austria)

    2009-09-15

    Compared to agricultural lands, forests are complex ecosystems as they can involve diverse plant species associations, several vegetative strata (overstorey, shrubs, herbaceous and other annual plant layer) and multi-layered soil profiles (forest floor, hemi-organic and mineral layers). A high degree of variability is thus generally observed in radionuclide transfers and redistribution patterns in contaminated forests. In the long term, the soil compartment represents the major reservoir of radionuclides which can give rise to long-term plant and hence food contamination. For practical reasons, the contamination of various specific forest products has commonly been quantified using the aggregated transfer factor (T{sub ag} in m{sup 2} kg{sup -1}) which integrates various environmental parameters including soil and plant type, root distribution as well as nature and vertical distribution of the deposits. Long lasting availability of some radionuclides was shown to be the source of much higher transfer in forest ecosystems than in agricultural lands. This study aimed at reviewing the most relevant quantitative information on radionuclide transfers to forest biota including trees, understorey vegetation, mushrooms, berries and game animals. For both radiocaesium and radiostrontium in trees, the order of magnitude of mean T{sub ag} values was 10{sup -3} m{sup 2} kg{sup -1} (dry weight). Tree foliage was usually 2-12 times more contaminated than trunk wood. Maximum contamination of tree components with radiocaesium was associated with (semi-)hydromorphic areas with thick humus layers. The transfer of radionuclides to mushrooms and berries is high, in comparison with foodstuffs grown in agricultural systems. Concerning caesium uptake by mushrooms, the transfer is characterized by a very large variability of T{sub ag}, from 10{sup -3} to 10{sup 1} m{sup 2} kg{sup -1} (dry weight). For berries, typical values are around 0.01-0.1 m{sup 2} kg{sup -1} (dry weight). Transfer

  9. The Estimation of Compaction Parameter Values Based on Soil Properties Values Stabilized with Portland Cement

    Science.gov (United States)

    Lubis, A. S.; Muis, Z. A.; Pasaribu, M. I.

    2017-03-01

    The strength and durability of pavement construction is highly dependent on the properties and subgrade bearing capacity. This then led to the idea of the selection methods to estimate the density of the soil with the proper implementation of the system, fast and economical. This study aims to estimate the compaction parameter value namely the maximum dry unit weight (γd max) and optimum moisture content (wopt) of the soil properties value that stabilized with Portland Cement. Tests conducted in the laboratory of soil mechanics to determine the index properties (fines and liquid limit) and Standard Compaction Test. Soil samples that have Plasticity Index (PI) between 0-15% then mixed with Portland Cement (PC) with variations of 2%, 4%, 6%, 8% and 10%, each 10 samples. The results showed that the maximum dry unit weight (γd max) and wopt has a significant relationship with percent fines, liquid limit and the percentation of cement. Equation for the estimated maximum dry unit weight (γd max) = 1.782 - 0.011*LL + 0,000*F + 0.006*PS with R2 = 0.915 and the estimated optimum moisture content (wopt) = 3.441 + 0.594*LL + 0,025*F + 0,024*PS with R2 = 0.726.

  10. Standardized perfusion value of the esophageal carcinoma and its correlation with quantitative CT perfusion parameter values

    Energy Technology Data Exchange (ETDEWEB)

    Djuric-Stefanovic, A., E-mail: avstefan@eunet.rs [Faculty of Medicine, University of Belgrade, Belgrade (Serbia); Unit of Digestive Radiology (First University Surgical Clinic), Center of Radiology and MR, Clinical Center of Serbia, Belgrade (Serbia); Saranovic, Dj., E-mail: crvzve4@gmail.com [Faculty of Medicine, University of Belgrade, Belgrade (Serbia); Unit of Digestive Radiology (First University Surgical Clinic), Center of Radiology and MR, Clinical Center of Serbia, Belgrade (Serbia); Sobic-Saranovic, D., E-mail: dsobic2@gmail.com [Faculty of Medicine, University of Belgrade, Belgrade (Serbia); Center of Nuclear Medicine, Clinical Center of Serbia, Belgrade (Serbia); Masulovic, D., E-mail: draganmasulovic@yahoo.com [Faculty of Medicine, University of Belgrade, Belgrade (Serbia); Unit of Digestive Radiology (First University Surgical Clinic), Center of Radiology and MR, Clinical Center of Serbia, Belgrade (Serbia); Artiko, V., E-mail: veraart@beotel.rs [Faculty of Medicine, University of Belgrade, Belgrade (Serbia); Center of Nuclear Medicine, Clinical Center of Serbia, Belgrade (Serbia)

    2015-03-15

    Purpose: Standardized perfusion value (SPV) is a universal indicator of tissue perfusion, normalized to the whole-body perfusion, which was proposed to simplify, unify and allow the interchangeability among the perfusion measurements and comparison between the tumor perfusion and metabolism. The aims of our study were to assess the standardized perfusion value (SPV) of the esophageal carcinoma, and its correlation with quantitative CT perfusion measurements: blood flow (BF), blood volume (BV), mean transit time (MTT) and permeability surface area product (PS) of the same tumor volume samples, which were obtained by deconvolution-based CT perfusion analysis. Methods: Forty CT perfusion studies of the esophageal cancer were analyzed, using the commercial deconvolution-based CT perfusion software (Perfusion 3.0, GE Healthcare). The SPV of the esophageal tumor and neighboring skeletal muscle were correlated with the corresponding mean tumor and muscle quantitative CT perfusion parameter values, using Spearman's rank correlation coefficient (r{sub S}). Results: Median SPV of the esophageal carcinoma (7.1; range: 2.8–13.4) significantly differed from the SPV of the skeletal muscle (median: 1.0; range: 0.4–2.4), (Z = −5.511, p < 0.001). The cut-off value of the SPV of 2.5 enabled discrimination of esophageal cancer from the skeletal muscle with sensitivity and specificity of 100%. SPV of the esophageal carcinoma significantly correlated with corresponding tumor BF (r{sub S} = 0.484, p = 0.002), BV (r{sub S} = 0.637, p < 0.001) and PS (r{sub S} = 0.432, p = 0.005), and SPV of the skeletal muscle significantly correlated with corresponding muscle BF (r{sub S} = 0.573, p < 0.001), BV (r{sub S} = 0.849, p < 0.001) and PS (r{sub S} = 0.761, p < 0.001). Conclusions: We presented a database of the SPV for the esophageal cancer and proved that SPV of the esophageal neoplasm significantly differs from the SPV of the skeletal muscle, which represented a sample of healthy

  11. Researches Regarding Microbiological Parameters Values of Telemea Cheese

    Directory of Open Access Journals (Sweden)

    Andra Suler

    2010-10-01

    Full Text Available The main objectives of this paper were microbiological parameters which characterized the Telemea cheese for each season, assessment of technologies and thus assortment defects as well as projection of hygienic solution for obtaining qualitative products according to actual standards. We studied 5 units of Telemea cheese processing replaced in different area. For obtaining concrete results we used STAS methodologies and analyze procedure was based on observation, mathematical estimation and experiments (in lab and processing units.

  12. Psychological context of work meaningfulness

    Directory of Open Access Journals (Sweden)

    Karel Paulík

    2014-12-01

    Full Text Available There is a significant shift of approach to the management of organizations and workers in recent decades. This shift in management philosophy is characterized by converting from traditional, conventional (rather bureaucratic management models to rather humanistic/existential oriented models. This transition comes partly from the understanding that human resources are the most promising and effective way for organization development, partly from a shift in the understanding of the role of organizations in society. The key point of these approaches has become a "meaning" or "meaningfulness" in relation to the work and organization. The importance of work meaningfulness is not only in its potential to increase the competitiveness of organizations, but especially in its major (mostly positive impacts on the employee himself and his work (and by that the organization and its performance. Work meaningfulness is strongly connected to the work engagement, which represents the active personal participation in the work process, manifested by vigor, active cooperation, willingness to contribute to the company's success and dedication to work. Work engagement seems to be next important factor affecting work attitudes and achievements of employees. The paper gives an overview of various approaches to work meaningfulness and work engagement, on the basis of which authors propose new model of work meaningfulness with overlap to work engagement. The work meaningfulness is not seen as one-dimensional variable, but consists of complex of interacting factors and processes that define an individual perceived meaning and importance of the work. Meaningful work is influenced by three areas. The first is the organizational culture. This is defined as a specific pattern of values, norms, beliefs, attitudes and assumptions that are often not clearly expressed, but affect the way individuals behave in an organization and how things are done. The second area is the work

  13. Meaningful and Purposeful Practice

    Science.gov (United States)

    Clementi, Donna

    2014-01-01

    This article describes a graphic, designed by Clementi and Terrill, the authors of "Keys to Planning for Learning" (2013), visually representing the components that contribute to meaningful and purposeful practice in learning a world language, practice that leads to greater proficiency. The entire graphic is centered around the letter…

  14. [Diagnostic value of quantitative pharmacokinetic parameters and relative quantitative pharmacokinetic parameters in breast lesions with dynamic contrast-enhanced MRI].

    Science.gov (United States)

    Sun, T T; Liu, W H; Zhang, Y Q; Li, L H; Wang, R; Ye, Y Y

    2017-08-01

    Objective: To explore the differential between the value of dynamic contrast-enhanced MRI quantitative pharmacokinetic parameters and relative pharmacokinetic quantitative parameters in breast lesions. Methods: Retrospective analysis of 255 patients(262 breast lesions) who was obtained by clinical palpation , ultrasound or full-field digital mammography , and then all lessions were pathologically confirmed in Zhongda Hospital, Southeast University from May 2012 to May 2016. A 3.0 T MRI scanner was used to obtain the quantitative MR pharmacokinetic parameters: volume transfer constant (K(trans)), exchange rate constant (k(ep))and extravascular extracellular volume fraction (V(e)). And measured the quantitative pharmacokinetic parameters of normal glands tissues which on the same side of the same level of the lesions; and then calculated the value of relative pharmacokinetic parameters: rK(rans)、rk(ep) and rV(e).To explore the diagnostic value of two pharmacokinetic parameters in differential diagnosis of benign and malignant breast lesions using receiver operating curves and model of logistic regression. Results: (1)There were significant differences between benign lesions and malignant lesions in K(trans) and k(ep) ( t =15.489, 15.022, respectively, P 0.05). The areas under the ROC curve(AUC)of K(trans), k(ep) and V(e) between malignant and benign lesions were 0.933, 0.948 and 0.387, the sensitivity of K(trans), k(ep) and V(e) were 77.1%, 85.0%, 51.0% , and the specificity of K(trans), k(ep) and V(e) were 96.3%, 93.6%, 60.8% for the differential diagnosis of breast lesions if taken the maximum Youden's index as cut-off. (2)There were significant differences between benign lesions and malignant lesions in rK(trans), rk(ep) and rV(e) ( t =14.177, 11.726, 2.477, respectively, P quantitative pharmacokinetic parameters and the prediction probability of relative quantitative pharmacokinetic parameters( Z =0.867, P =0.195). Conclusion: There was no significant

  15. Reflow Process Parameters Analysis and Reliability Prediction Considering Multiple Characteristic Values

    Directory of Open Access Journals (Sweden)

    Guo Yu

    2016-01-01

    Full Text Available As a major step surface mount technology, reflow process is the key factor affecting the quality of the final product. The setting parameters and characteristic value of temperature curve shows a nonlinear relationship. So parameter impacts on characteristic values are analyzed and the parameters adjustment process based on orthogonal experiment is proposed in the paper. First, setting parameters are determined and the orthogonal test is designed according to production conditions. Then each characteristic value for temperature profile is calculated. Further, multi-index orthogonal experiment is analyzed for acquiring the setting parameters which impacts the PCBA product quality greater. Finally, reliability prediction is carried out considering the main influencing parameters for providing a theoretical basis of parameters adjustment and product quality evaluation in engineering process.

  16. Quality-adjusted cost of care: a meaningful way to measure growth in innovation cost versus the value of health gains.

    Science.gov (United States)

    Lakdawalla, Darius; Shafrin, Jason; Lucarelli, Claudio; Nicholson, Sean; Khan, Zeba M; Philipson, Tomas J

    2015-04-01

    Technology drives both health care spending and health improvement. Yet policy makers rarely see measures of cost growth that account for both effects. To fill this gap, we present the quality-adjusted cost of care, which illustrates cost growth net of growth in the value of health improvements, measured as survival gains multiplied by the value of survival. We applied the quality-adjusted cost of care to two cases. For colorectal cancer, drug cost per patient increased by $34,493 between 1998 and 2005 as a result of new drug launches, but value from offsetting health improvements netted a modest $1,377 increase in quality-adjusted cost of care. For multiple myeloma, new therapies increased treatment cost by $72,937 between 2004 and 2009, but offsetting health benefits lowered overall quality-adjusted cost of care by $67,863. However, patients with multiple myeloma on established first-line therapies saw costs rise without corresponding benefits. All three examples document rapid cost growth, but they provide starkly different answers to the question of whether society got what it paid for. Project HOPE—The People-to-People Health Foundation, Inc.

  17. Reflections on Meaningfulness and its Social Relevance

    Directory of Open Access Journals (Sweden)

    Nicole Note

    2010-06-01

    Full Text Available Philosophers who write about the meaning of life are few nowadays. Thesubject has lost its attractiveness. Perceived from a viewpoint of logical positivism or language philosophy, the whole issue of meaningfulness seems rather pointless. It is often considered to be related to metaphysics, making it less suitable for philosophical inquiry. The topic of meaningfulness seems too intangible. Indeed, the few philosophers that have embarked on examining meaningfulness have proven to be well aware of the challenges this poses. At times they acknowledge that the more they concentrate on the subject, the more it seems to fall apart into unintelligible pieces about whichnothing of philosophical value can be said.

  18. Reference values of clinical chemistry and hematology parameters in rhesus monkeys (Macaca mulatta).

    Science.gov (United States)

    Chen, Younan; Qin, Shengfang; Ding, Yang; Wei, Lingling; Zhang, Jie; Li, Hongxia; Bu, Hong; Lu, Yanrong; Cheng, Jingqiu

    2009-01-01

    Rhesus monkey models are valuable to the studies of human biology. Reference values for clinical chemistry and hematology parameters of rhesus monkeys are required for proper data interpretation. Whole blood was collected from 36 healthy Chinese rhesus monkeys (Macaca mulatta) of either sex, 3 to 5 yr old. Routine chemistry and hematology parameters, and some special coagulation parameters including thromboelastograph and activities of coagulation factors were tested. We presented here the baseline values of clinical chemistry and hematology parameters in normal Chinese rhesus monkeys. These data may provide valuable information for veterinarians and investigators using rhesus monkeys in experimental studies.

  19. Extreme values of meteorological parameters observed at Kalpakkam during the period 1968-1999

    International Nuclear Information System (INIS)

    Balagurunathan, M.R.; Chandresekharan, E.; Rajan, M.P.; Gurg, R.P.

    2001-05-01

    In the design phase of engineering structures, an understanding of extreme weather conditions that may occur at the site of interest is very essential, so that the structures can be designed to withstand climatological stresses during its life time. In this report an analysis of extreme values of meteorological parameters at Kalpakkam for the period 1968-99, which provide an insight into such situations is described. The extreme value analysis reveals that all the variables obey Fisher-Tippet Type-I extreme value distribution function. Parameter values of extreme value analysis functions are presented for the variables studied and the 50- and 100- year return period extreme values are arrived at. Frequency distribution of rainfall parameters is investigated. Time series of annual rainfall data suggests a cycle of 2-3 years period. (author)

  20. Parameter values for the Heysham site for use in the CODAR2 program

    International Nuclear Information System (INIS)

    Maul, P.R.

    1985-03-01

    Details are given of parameter values relevant to the Heysham site for the calculation of individual and collective radiation exposure arising from routine discharges of liquid effluent to the sea. These parameters are to be used in the CODAR2 computer program, and the approach taken in their specification is the same as that employed previously for the Sizewell site. (author)

  1. A direct method for computing extreme value (Gumbel) parameters for gapped biological sequence alignments.

    Science.gov (United States)

    Quinn, Terrance; Sinkala, Zachariah

    2014-01-01

    We develop a general method for computing extreme value distribution (Gumbel, 1958) parameters for gapped alignments. Our approach uses mixture distribution theory to obtain associated BLOSUM matrices for gapped alignments, which in turn are used for determining significance of gapped alignment scores for pairs of biological sequences. We compare our results with parameters already obtained in the literature.

  2. Life is pretty meaningful.

    Science.gov (United States)

    Heintzelman, Samantha J; King, Laura A

    2014-09-01

    The human experience of meaning in life is widely viewed as a cornerstone of well-being and a central human motivation. Self-reports of meaning in life relate to a host of important functional outcomes. Psychologists have portrayed meaning in life as simultaneously chronically lacking in human life as well as playing an important role in survival. Examining the growing literature on meaning in life, we address the question "How meaningful is life, in general?" We review possible answers from various psychological sources, some of which anticipate that meaning in life should be low and others that it should be high. Summaries of epidemiological data and research using two self-report measures of meaning in life suggest that life is pretty meaningful. Diverse samples rate themselves significantly above the midpoint on self-reports of meaning in life. We suggest that if meaning in life plays a role in adaptation, it must be commonplace, as our analysis suggests. (c) 2014 APA, all rights reserved.

  3. Assessment on Evaluating Parameters of Rice Core Collections Constructed by Genotypic Values and Molecular Marker Information

    Directory of Open Access Journals (Sweden)

    Jian-cheng WANG

    2007-06-01

    Full Text Available Eleven evaluating parameters for rice core collection were assessed based on genotypic values and molecular marker information. Monte Carlo simulation combined with mixed linear model was used to eliminate the interference from environment in order to draw more reliable results. The coincidence rate of range (CR was the optimal parameter. Mean Simpson index (MD, mean Shannon-Weaver index of genetic diversity (MI and mean polymorphism information content (MPIC were important evaluating parameters. The variable rate of coefficient of variation (VR could act as an important reference parameter for evaluating the variation degree of core collection. Percentage of polymorphic loci (p could be used as a determination parameter for the size of core collection. Mean difference percentage (MD was a determination parameter for the reliability judgment of core collection. The effective evaluating parameters for core collection selected in the research could be used as criteria for sampling percentage in different plant germplasm populations.

  4. The values of the parameters of some multilayer distributed RC null networks

    Science.gov (United States)

    Huelsman, L. P.; Raghunath, S.

    1974-01-01

    In this correspondence, the values of the parameters of some multilayer distributed RC notch networks are determined, and the usually accepted values are shown to be in error. The magnitude of the error is illustrated by graphs of the frequency response of the networks.

  5. Protestant ethic: Contributing towards a meaningful workplace ...

    African Journals Online (AJOL)

    The article also indicates that the Protestant ethic can indeed contribute towards a meaningful experience whilst performing work-related tasks in workspace. The Protestant work ethic is more than a cultural norm that places a positive moral value on doing a good job. Based on a belief that work has intrinsic value for its own ...

  6. The estimation of parameter compaction values for pavement subgrade stabilized with lime

    Science.gov (United States)

    Lubis, A. S.; Muis, Z. A.; Simbolon, C. A.

    2018-02-01

    The type of soil material, field control, maintenance and availability of funds are several factors that must be considered in compaction of the pavement subgrade. In determining the compaction parameters in laboratory desperately requires considerable materials, time and funds, and reliable laboratory operators. If the result of soil classification values can be used to estimate the compaction parameters of a subgrade material, so it would save time, energy, materials and cost on the execution of this work. This is also a clarification (cross check) of the work that has been done by technicians in the laboratory. The study aims to estimate the compaction parameter values ie. maximum dry unit weight (γdmax) and optimum water content (Wopt) of the soil subgrade that stabilized with lime. The tests that conducted in the laboratory of soil mechanics were to determine the index properties (Fines and Liquid Limit/LL) and Standard Compaction Test. Soil samples that have Plasticity Index (PI) > 10% were made with additional 3% lime for 30 samples. By using the Goswami equation, the compaction parameter values can be estimated by equation γd max # = -0,1686 Log G + 1,8434 and Wopt # = 2,9178 log G + 17,086. From the validation calculation, there was a significant positive correlation between the compaction parameter values laboratory and the compaction parameter values estimated, with a 95% confidence interval as a strong relationship.

  7. Normal Values for Heart Electrophysiology Parameters of Healthy Swine Determined on Electrophysiology Study.

    Science.gov (United States)

    Noszczyk-Nowak, Agnieszka; Cepiel, Alicja; Janiszewski, Adrian; Pasławski, Robert; Gajek, Jacek; Pasławska, Urszula; Nicpoń, Józef

    2016-01-01

    Swine are a well-recognized animal model for human cardiovascular diseases. Despite the widespread use of porcine model in experimental electrophysiology, still no reference values for intracardiac electrical activity and conduction parameters determined during an invasive electrophysiology study (EPS) have been developed in this species thus far. The aim of the study was to develop a set of normal values for intracardiac electrical activity and conduction parameters determined during an invasive EPS of swine. The study included 36 healthy domestic swine (24-40 kg body weight). EPS was performed under a general anesthesia with midazolam, propofol and isoflurane. The reference values for intracardiac electrical activity and conduction parameters were calculated as arithmetic means ± 2 standard deviations. The reference values were determined for AH, HV and PA intervals, interatrial conduction time at its own and imposed rhythm, sinus node recovery time (SNRT), corrected sinus node recovery time (CSNRT), anterograde and retrograde Wenckebach points, atrial, atrioventricular node and ventricular refractory periods. No significant correlations were found between body weight and heart rate of the examined pigs and their electrophysiological parameters. The hereby presented reference values can be helpful in comparing the results of various studies, as well as in more accurately estimating the values of electrophysiological parameters that can be expected in a given experiment.

  8. Recommended food chain parameter values and distributions for use around CANDU sites in Ontario

    Energy Technology Data Exchange (ETDEWEB)

    Peterson, S R

    1996-07-01

    Site-specific parameter values should be used whenever possible to increase the accuracy of dose predictions. Parameter values specific to agricultural practices and human lifestyles in southern Ontario are presented for use in CSA-N288.1-M87 (Canadian Standards Association Guidelines for Calculating Derived Release Limits for Radioactive Material in Airborne and Liquid Effluents for Normal Operation of Nuclear Facilities) and CHERPAC (Chalk River Environmental Research Pathways Analysis Code). Use of these values in place of the default parameter values in CSA-N288.1-M87 is shown to reduce the predicted dose by nearly a factor of 2. (author). 27 refs., 6 tabs., 1 fig.

  9. Recommended food chain parameter values and distributions for use around CANDU sites in Ontario

    International Nuclear Information System (INIS)

    Peterson, S.R.

    1996-07-01

    Site-specific parameter values should be used whenever possible to increase the accuracy of dose predictions. Parameter values specific to agricultural practices and human lifestyles in southern Ontario are presented for use in CSA-N288.1-M87 (Canadian Standards Association Guidelines for Calculating Derived Release Limits for Radioactive Material in Airborne and Liquid Effluents for Normal Operation of Nuclear Facilities) and CHERPAC (Chalk River Environmental Research Pathways Analysis Code). Use of these values in place of the default parameter values in CSA-N288.1-M87 is shown to reduce the predicted dose by nearly a factor of 2. (author). 27 refs., 6 tabs., 1 fig

  10. Sensitivity of NTCP parameter values against a change of dose calculation algorithm

    International Nuclear Information System (INIS)

    Brink, Carsten; Berg, Martin; Nielsen, Morten

    2007-01-01

    Optimization of radiation treatment planning requires estimations of the normal tissue complication probability (NTCP). A number of models exist that estimate NTCP from a calculated dose distribution. Since different dose calculation algorithms use different approximations the dose distributions predicted for a given treatment will in general depend on the algorithm. The purpose of this work is to test whether the optimal NTCP parameter values change significantly when the dose calculation algorithm is changed. The treatment plans for 17 breast cancer patients have retrospectively been recalculated with a collapsed cone algorithm (CC) to compare the NTCP estimates for radiation pneumonitis with those obtained from the clinically used pencil beam algorithm (PB). For the PB calculations the NTCP parameters were taken from previously published values for three different models. For the CC calculations the parameters were fitted to give the same NTCP as for the PB calculations. This paper demonstrates that significant shifts of the NTCP parameter values are observed for three models, comparable in magnitude to the uncertainties of the published parameter values. Thus, it is important to quote the applied dose calculation algorithm when reporting estimates of NTCP parameters in order to ensure correct use of the models

  11. Hematological parameters in relation to age, sex and biochemical values for mute swans (Cygnus olor).

    Science.gov (United States)

    Dolka, B; Włodarczyk, R; Zbikowski, A; Dolka, I; Szeleszczuk, P; Kluciński, W

    2014-06-01

    The knowledge of the correct morphological and biochemical parameters in mute swans is an important indicator of their health status, body condition, adaptation to habitat and useful diagnostic tools in veterinary practice and ecological research. The aim of the study was to obtain hematological parameters in relation to age, sex and serum biochemistry values in wild-living mute swans. We found the significant differences in the erythrocyte count, hematocrit, hemoglobin concentration and erythrocyte sedimentation rate in relation to age of mute swans. There were no differences in hematological values between males and females. The leukogram and H/L ratio did not vary by age and sex in swans. Among of biochemical parameters the slightly increased AST, ALP, CK, K, urea, decreased CHOL and TG values were recorded. As far as we know, this is the first study in which the morphometric parameters of blood cells in mute swans were presented. We found extremely low concentration of lead in blood (at subthreshold level). No blood parasites were found in blood smears. The analysis of body mass and biometric parameters revealed a significant differences dependent on age and sex. No differences in the scaled mass index were found. Our results represent a normal hematologic and blood chemistry values and age-sex related changes, as reference values for the mute swan.

  12. Site-specific parameter values for the Nuclear Regulatory Commission's food pathway dose model

    International Nuclear Information System (INIS)

    Hamby, D.M.

    1992-01-01

    Routine operations at the Savannah River Site (SRS) in Western South Carolina result in radionuclide releases to the atmosphere and to the Savannah River. The resulting radiation doses to the off-site maximum individual and the off-site population within 80 km of the SRS are estimated on a yearly basis. These estimates are currently generated using dose models prescribed for the commercial nuclear power industry by the Nuclear Regulatory Commission (NRC). The NRC provides default values for dose-model parameters for facilities without resources to develop site-specific values. A survey of land- and water-use characteristics for the Savannah River area has been conducted to determine site-specific values for water recreation, consumption, and agricultural parameters used in the NRC Regulatory Guide 1.109 (1977) dosimetric models. These site parameters include local characteristics of meat, milk, and vegetable production; recreational and commercial activities on the Savannah River; and meat, milk, vegetable, and seafood consumption rates. This paper describes how parameter data were obtained at the Savannah River Site and the impacts of such data on off-site dose. Dose estimates using site-specific parameter values are compared to estimates using the NRC default values

  13. Meaningful work, work engagement and organisational commitment

    Directory of Open Access Journals (Sweden)

    Madelyn Geldenhuys

    2014-03-01

    Research purpose: The aim of the study was to investigate the relationships amongst psychological meaningfulness, work engagement and organisational commitment and to test for a possible mediation effect of work engagement on the relationship between psychological meaningfulness and organisational commitment. Motivation for the study: Managers have to rethink ways of improving productivity and performance at work, due to the diverse, and in some instances escalating, needs of employees (e.g. financial support to uphold their interest in and enjoyment of working. Research approach, design and method: A quantitative approach was employed to gather the data for the study, utilising a cross-sectional survey design. The sample (n = 415 consisted of working employees from various companies and positions in Gauteng, South Africa. Main findings: The results confirmed a positive relationship between psychological meaningfulness, work engagement and organisational commitment. Further, psychological meaningfulness predicts work engagement, whilst psychological meaningfulness and work engagement predict organisational commitment. Practical/managerial implications: Employers identifying their employees’ commitment patterns and mapping out strategies for enhancing those that are relevant to organisational goals will yield positive work outcomes (e.g. employees who are creative, seek growth or challenges for themselves. Contribution/value-add: This study contributes to the literature through highlighting the impact that meaningful work has on sustaining employee commitment to the organisation.

  14. Value as a parameter to consider in operational strategies for CSP plants

    Science.gov (United States)

    de Meyer, Oelof; Dinter, Frank; Govender, Saneshan

    2017-06-01

    This paper introduced a value parameter to consider when analyzing operational strategies for CSP plants. The electric system in South Africa, used as case study, is severely constrained with an influx of renewables in the early phase of deployment. The energy demand curve for the system is analyzed showing the total wind and solar photovoltaic contributions for winter and summer. Due to the intermittent nature and meteorological operating conditions of wind and solar photovoltaic plants, the value of CSP plants within the electric system is introduced. Analyzing CSP plants based on the value parameter alone will remain only a philosophical view. Currently there is no quantifiable measure to translate the philosophical view or subjective value and it solely remains the position of the stakeholder. By introducing three other parameters, Cost, Plant and System to a holistic representation of the Operating Strategies of generation plants, the Value parameter can be translated into a quantifiable measure. Utilizing the country's current procurement program as case study, CSP operating under the various PPA within the Bid Windows are analyzed. The Value Cost Plant System diagram developed is used to quantify the value parameter. This paper concluded that no value is obtained from CSP plants operating under the Bid Window 1 & 2 Power Purchase Agreement. However, by recognizing the dispatchability potential of CSP plants in Bid Window 3 & 3.5, the value of CSP in the electric system can be quantified utilizing Value Added Relationship VCPS-diagram. Similarly ancillary services to the system were analyzed. One of the relationships that have not yet been explored within the industry is an interdependent relationship. It was emphasized that the cost and value structure is shared between the plant and system. Although this relationship is functional when the plant and system belongs to the same entity, additional value is achieved by marginalizing the cost structure. A

  15. Parameter values for the long-term nuclear waste management food chain model LIMCAL

    International Nuclear Information System (INIS)

    Zach, Reto.

    1982-09-01

    Eighteen parameters of LIMCAL, a comprehensive food chain model for predicting ICRP 26 50-year committed effective dose equivalents to man due to long-term nuclear waste management are reviewed. The parameters are: soil bulk density, plowlayer depth, soil surface layer depth, resusupension factor, atmospheric dust load, deposition velocity, plant interception fraction, plant environmental half-time, translocation factor, time of above-ground exposure, plant yield, holdup time, animals' feed consumption rate, animals' water consumption rate, man's water consumption rate, food type calorie conversion factors, man's total caloric intake rate and food type calorie fractions. LIMCAL has both traditional and unique parameters. The former occur in most of the currently used assessment models for nuclear installations, whereas the latter do not. For each of the parameters of LIMCAL, a suitable generic value for long-term nuclear waste management was determined. Thus, the general literature and the values currently used or recommended by various agencies were reviewed

  16. Recommended Parameter Values for GENII Modeling of Radionuclides in Routine Air and Water Releases

    Energy Technology Data Exchange (ETDEWEB)

    Snyder, Sandra F. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Arimescu, Carmen [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Napier, Bruce A. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Hay, Tristan R. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States)

    2012-11-01

    The GENII v2 code is used to estimate dose to individuals or populations from the release of radioactive materials into air or water. Numerous parameter values are required for input into this code. User-defined parameters cover the spectrum from chemical data, meteorological data, agricultural data, and behavioral data. This document is a summary of parameter values that reflect conditions in the United States. Reasonable regional and age-dependent data is summarized. Data availability and quality varies. The set of parameters described address scenarios for chronic air emissions or chronic releases to public waterways. Considerations for the special tritium and carbon-14 models are briefly addressed. GENIIv2.10.0 is the current software version that this document supports.

  17. Multiple and sign-changing solutions for discrete Robin boundary value problem with parameter dependence

    Directory of Open Access Journals (Sweden)

    Long Yuhua

    2017-12-01

    Full Text Available In this paper, we study second-order nonlinear discrete Robin boundary value problem with parameter dependence. Applying invariant sets of descending flow and variational methods, we establish some new sufficient conditions on the existence of sign-changing solutions, positive solutions and negative solutions of the system when the parameter belongs to appropriate intervals. In addition, an example is given to illustrate our results.

  18. A New Five-Parameter Fréchet Model for Extreme Values

    Directory of Open Access Journals (Sweden)

    Muhammad Ahsan ul Haq

    2017-09-01

    Full Text Available A new five parameter Fréchet model for Extreme Values was proposed and studied. Various mathematical properties including moments, quantiles, and moment generating function were derived. Incomplete moments and probability weighted moments were also obtained. The maximum likelihood method was used to estimate the model parameters. The flexibility of the derived model was accessed using two real data set applications.

  19. Extreme value analysis of meterological parameters observed at Narora during the period 1989-2001

    International Nuclear Information System (INIS)

    Varakhedkar, V.K.; Dube, B.; Gurg, R.P.

    2002-08-01

    The design of engineering structures requires an understanding of extreme weather conditions that may occur at the site of interest, which is very essential, so that the structures can be designed to withstand weather stresses. In this report an analysis of extreme values of meteorological parameters observed at Narora for the period 1989- 2001 is described. The parameters considered are maximum and minimum air temperature, minimum relative humidity, maximum wind speed, maximum rainfall in a day and month, and annual rainfall. The extreme value analysis reveals that the variables such as annual maximum air temperature, minimum relative humidity and monthly maximum rainfall obey Fisher -Tippet Type -I extreme value distribution where as annual minimum air temperature, maximum hourly wind speed, daily maximum rainfall and maximum and minimum annual rainfall, obey Fisher -Tippet Type -2 extreme value distribution function. Various distribution function parameters for each variable are determined. Extreme values corresponding to return periods of 50 years and 100 years are worked out. These derived extreme values are particularly useful for arriving at suitable design values to ensure the safety of any civil structure in Narora area with respect to stresses due to weather conditions. (author)

  20. New parameters and reference values for monitoring iron status in Middle Eastern adolescent male athletes.

    Science.gov (United States)

    Voss, S C; Varamenti, E; Elzain Elgingo, M; Bourdon, P C

    2014-04-01

    Hematological and biochemical parameters of 160 Middle Eastern adolescent male athletes (aged from 12-18 years) were tested in order to investigate their iron status and to establish reference values for this population. A focus of this study was also the investigation of Reticulocyte hemoglobin (RetHe) and soluble transferrin receptor (sTfR). Complete blood count, reticulocyte and sera parameters were analyzed at the beginning of the training season for these adolescent athletes. As the diagnosis of iron deficiency in adolescents is extremely difficult subjects were subdivided in three age groups (12-13, 14-15, 16-18). For most of the parameters our results confirmed the existing reference values reported in young athletes. Exceptions were however found with lower Mean Cell Volumes (79.9±4.3 fl) in this group when compared to other age matched data. RetHe, ferritin and sTfR levels were monitored for the interpretation of the iron status in this population and reference values for these parameters were also established. Information to help evidence based decision making about the need for supplementation or further investigations is provided to physicians and nutritionists. RetHe with a proposed threshold value of 25 pg expands the list of parameters which can be used to monitor athletes.

  1. Modeling phosphorus in the Lake Allatoona watershed using SWAT: I. Developing phosphorus parameter values.

    Science.gov (United States)

    Radcliffe, D E; Lin, Z; Risse, L M; Romeis, J J; Jackson, C R

    2009-01-01

    Lake Allatoona is a large reservoir north of Atlanta, GA, that drains an area of about 2870 km2 scheduled for a phosphorus (P) total maximum daily load (TMDL). The Soil and Water Assessment Tool (SWAT) model has been widely used for watershed-scale modeling of P, but there is little guidance on how to estimate P-related parameters, especially those related to in-stream P processes. In this paper, methods are demonstrated to individually estimate SWAT soil-related P parameters and to collectively estimate P parameters related to stream processes. Stream related parameters were obtained using the nutrient uptake length concept. In a manner similar to experiments conducted by stream ecologists, a small point source is simulated in a headwater sub-basin of the SWAT models, then the in-stream parameter values are adjusted collectively to get an uptake length of P similar to the values measured in the streams in the region. After adjusting the in-stream parameters, the P uptake length estimated in the simulations ranged from 53 to 149 km compared to uptake lengths measured by ecologists in the region of 11 to 85 km. Once the a priori P-related parameter set was developed, the SWAT models of main tributaries to Lake Allatoona were calibrated for daily transport. Models using SWAT P parameters derived from the methods in this paper outperformed models using default parameter values when predicting total P (TP) concentrations in streams during storm events and TP annual loads to Lake Allatoona.

  2. Estimation of the location parameter of distributions with known coefficient of variation by record values

    Directory of Open Access Journals (Sweden)

    N. K. Sajeevkumar

    2014-09-01

    Full Text Available In this article, we derived the Best Linear Unbiased Estimator (BLUE of the location parameter of certain distributions with known coefficient of variation by record values. Efficiency comparisons are also made on the proposed estimator with some of the usual estimators. Finally we give a real life data to explain the utility of results developed in this article.

  3. An alternative approach to absolute-value test for the parameters of ...

    African Journals Online (AJOL)

    An alternative approach to absolute-value test statistic Mn is developed for conducting tests simultaneously on all the parameters of multiple linear regression models. Under certain null and alternative hypotheses, the new test statistic is shown to have limiting central and noncentral chisquare distributions, respectively.

  4. Handbook of parameter values for the prediction of radionuclide transfer to wildlife

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2014-06-15

    This handbook provides generic parameter values for estimating the transfer of radionuclides from environmental media to wildlife for the purpose of assessing potential radiation exposure under equilibrium conditions. These data are intended for use where site specific data are either not available or not required, and to parameterize generic assessment models. They are based on a comprehensive review of the available literature, including many Russian language publications that have not previously been available in English. The publication addresses the limitations of the parameter values and the applicability of data. Some general background information on the assessment of potential impacts of radioactive releases on wildlife is also included. It complements the existing handbook in the same IAEA series with parameter to assess the radiological impact to humans.

  5. Influence of parameter values on the oscillation sensitivities of two p53-Mdm2 models.

    Science.gov (United States)

    Cuba, Christian E; Valle, Alexander R; Ayala-Charca, Giancarlo; Villota, Elizabeth R; Coronado, Alberto M

    2015-09-01

    Biomolecular networks that present oscillatory behavior are ubiquitous in nature. While some design principles for robust oscillations have been identified, it is not well understood how these oscillations are affected when the kinetic parameters are constantly changing or are not precisely known, as often occurs in cellular environments. Many models of diverse complexity level, for systems such as circadian rhythms, cell cycle or the p53 network, have been proposed. Here we assess the influence of hundreds of different parameter sets on the sensitivities of two configurations of a well-known oscillatory system, the p53 core network. We show that, for both models and all parameter sets, the parameter related to the p53 positive feedback, i.e. self-promotion, is the only one that presents sizeable sensitivities on extrema, periods and delay. Moreover, varying the parameter set values to change the dynamical characteristics of the response is more restricted in the simple model, whereas the complex model shows greater tunability. These results highlight the importance of the presence of specific network patterns, in addition to the role of parameter values, when we want to characterize oscillatory biochemical systems.

  6. Efficiently enclosing the compact binary parameter space by singular-value decomposition

    International Nuclear Information System (INIS)

    Cannon, Kipp; Hanna, Chad; Keppel, Drew

    2011-01-01

    Gravitational-wave searches for the merger of compact binaries use matched filtering as the method of detecting signals and estimating parameters. Such searches construct a fine mesh of filters covering a signal parameter space at high density. Previously it has been shown that singular-value decomposition can reduce the effective number of filters required to search the data. Here we study how the basis provided by the singular-value decomposition changes dimension as a function of template-bank density. We will demonstrate that it is sufficient to use the basis provided by the singular-value decomposition of a low-density bank to accurately reconstruct arbitrary points within the boundaries of the template bank. Since this technique is purely numerical, it may have applications to interpolating the space of numerical relativity waveforms.

  7. Normative Values and Interrelationship of MDVP Voice Analysis Parameters Before and After Endotracheal Intubation

    DEFF Research Database (Denmark)

    Sørensen, Martin Kryspin; Durck, Tina Trier; Bork, Kristian

    2016-01-01

    normative values for adults and investigates the correlation between these MDVP parameters in relation to the "standardized" trauma of endotracheal intubation. METHODS: Preoperative and postoperative assessments of vocal fold pathology with flexible videolaryngoscopy and voice analysis with MDVP using...... the best-of-three standardized recording were performed in 121 patients with normal voices included consecutively in the RCT. The procedures of anesthesia were standardized. RESULTS: The normative MDVP values of this study are consistently lower compared with most normative values presented in other...... studies. The preoperative to postoperative differences in jitter values (jitter and relative average perturbation) were closely correlated to the shimmer values for patients with postoperative vocal fold edemas. In the patients with edema, the preoperative to postoperative differences in jitter had...

  8. Potential Value of Coagulation Parameters for Suggesting Preeclampsia During the Third Trimester of Pregnancy.

    Science.gov (United States)

    Chen, Ying; Lin, Li

    2017-07-01

    Preeclampsia is a relatively common complication of pregnancy and considered to be associated with different degrees of coagulation dysfunction. This study was developed to evaluate the potential value of coagulation parameters for suggesting preeclampsia during the third trimester of pregnancy. Data from 188 healthy pregnant women, 125 patients with preeclampsia in the third trimester and 120 age-matched nonpregnant women were analyzed. Prothrombin time, prothrombin activity, activated partial thromboplastin time, fibrinogen (Fg), antithrombin, platelet count, mean platelet volume, platelet distribution width and plateletcrit were tested. All parameters, excluding prothrombin time, platelet distribution width and plateletcrit, differed significantly between healthy pregnant women and those with preeclampsia. Platelet count, antithrombin and Fg were significantly lower and mean platelet volume and prothrombin activity were significantly higher in patients with preeclampsia (P preeclampsia was 0.872 for Fg with an optimal cutoff value of ≤2.87g/L (sensitivity = 0.68 and specificity = 0.98). For severe preeclampsia, the area under the curve for Fg reached up to 0.922 with the same optimal cutoff value (sensitivity = 0.84, specificity = 0.98, positive predictive value = 0.96 and negative predictive value = 0.93). Fg is a biomarker suggestive of preeclampsia in the third trimester of pregnancy, and our data provide a potential cutoff value of Fg ≤ 2.87g/L for screening preeclampsia, especially severe preeclampsia. Copyright © 2017 Southern Society for Clinical Investigation. Published by Elsevier Inc. All rights reserved.

  9. Work engagement and meaningful work across generational cohorts

    Directory of Open Access Journals (Sweden)

    Crystal Hoole

    2015-08-01

    Full Text Available Orientation: Engaging employees and providing employees with a sense of meaning at work is not a one-size-fits-all approach. Although research has shown that differences between work engagement and meaningful work amongst generational cohorts exist, results are still inconclusive. With age becoming increasingly more important as a diversity factor, a better understanding of the dynamics between work engagement and meaningful work across different generational cohorts is necessary to design the right strategy for each organisation’s unique parameters. Research purpose: The aim of this study was to determine whether there is a relationship between work engagement and meaningful work and whether there are significant variances between the levels of work engagement and meaningful work between different generational cohorts. Motivation for study: Work engagement has consistently been highlighted by researchers and human resources experts as a recommended solution to provide companies with the upper hand when it comes to creating a competitive edge. Yet, levels of work engagement are far from ideal, requiring intensified efforts to identify solutions towards raising overall engagement levels. In recent years, much of the focus in terms of generating engagement has been aimed in the direction of financial rewards and other benefits; some organisational experts are of the opinion that a shift is occurring towards meaningful work instead of monetary rewards as the driver of engagement. The changing nature of the work landscape also suggests that generational cohorts experience work engagement and meaningful work differently. Understanding these complexities is mandatory in creating solutions towards improving levels of engagement and meaningful work. Research approach, design and method: A cross-sectional quantitative research approach has been followed. The Utrecht Work Engagement Scale (UWES and Psychological Meaningful Scale (PMS were administered

  10. Handbook of parameter values for the prediction of radionuclide transfer in temperate environments

    International Nuclear Information System (INIS)

    1994-01-01

    This Handbook has been prepared in response to a widely expressed interest in having a convenient and authoritative reference for radionuclide transfer parameter values used in biospheric assessment models. It draws on data from North America and Europe, much of which was collected through projects of the International Union of Radioecologists (IUR) and the Commission of European Communities (CEC) over the last decade. It is intended to supplement existing IAEA publications on environmental assessment methodology, primarily Generic Models and Parameters for Assessing the Environmental Transfer of Radionuclides from Routine Releases, IAEA Safety Series No. 57 (1982). 219 refs, 3 figs, 32 tabs

  11. Assessment of Optimum Value for Dip Angle and Locking Rate Parameters in Makran Subduction Zone

    Science.gov (United States)

    Safari, A.; Abolghasem, A. M.; Abedini, N.; Mousavi, Z.

    2017-09-01

    Makran subduction zone is one of the convergent areas that have been studied by spatial geodesy. Makran zone is located in the South Eastern of Iran and South of Pakistan forming the part of Eurasian-Arabian plate's border where oceanic crust in the Arabian plate (or in Oman Sea) subducts under the Eurasian plate ( Farhoudi and Karig, 1977). Due to lack of historical and modern tools in the area, a sampling of sparse measurements of the permanent GPS stations and temporary stations (campaign) has been conducted in the past decade. Makran subduction zone from different perspectives has unusual behaviour: For example, the Eastern and Western parts of the region have very different seismicity and also dip angle of subducted plate is in about 2 to 8 degrees that this value due to the dip angle in other subduction zone is very low. In this study, we want to find the best possible value for parameters that differs Makran subduction zone from other subduction zones. Rigid block modelling method was used to determine these parameters. From the velocity vectors calculated from GPS observations in this area, block model is formed. These observations are obtained from GPS stations that a number of them are located in South Eastern Iran and South Western Pakistan and a station located in North Eastern Oman. According to previous studies in which the locking depth of Makran subduction zone is 38km (Frohling, 2016), in the preparation of this model, parameter value of at least 38 km is considered. With this function, the amount of 2 degree value is the best value for dip angle but for the locking rate there is not any specified amount. Because the proposed model is not sensitive to this parameter. So we can not expect big earthquakes in West of Makran or a low seismicity activity in there but the proposed model definitely shows the Makran subduction layer is locked.

  12. Data Qualification Report For DTN: MO0012RIB00065.002, Parameter Values For Transfer Coefficients

    International Nuclear Information System (INIS)

    C.H. Tung

    2001-01-01

    A data-qualification evaluation was conducted on Reference Information Base (RIB) data set MOO0 12RIB00065.002, ''Parameter Values for Transfer Coefficients''. The corroborating data method was used to evaluate the data. This method was selected because it closely matches the literature-review method followed to select parameter values. Five criteria were considered when the corroborating method was used: adequacy of the corroborative literature, sufficiency of value-selection criteria, implementation of the selection criteria, documentation of the process, and whether the analysis was conducted in accordance with applicable quality assurance (QA) procedures. Three criteria were used when a literature review was not conducted: appropriate logic used to select parameters, documentation of the process, and whether the analysis was conducted in accordance with applicable QA procedures. The RIB data item, the associated Analysis and Model Report (AMR), the corroborative literature, and the results of an audit revision O/ICN--0 of the AMR were examined. All calculations and the selection process for all values were repeated and confirmed. The qualification team concluded: (1) A sufficient quantity of corroborative literature was reviewed and no additional literature was identified that should have been considered. (2) The selection criteria were sufficient and resulted in valid parameter values. (3) The process was well defined, adequately documented in the AMR, and correctly followed. (4) The analysis was developed in accordance with applicable QA procedures. No negative findings were documented that resulted in questions about the quality of the data. The qualification team therefore recommends that the qualification status of RIB data set MO0012RIB00065.002 be changed to qualified

  13. Clinical implications in laboratory parameter values in acute Kawasaki disease for early diagnosis and proper treatment.

    Science.gov (United States)

    Seo, Yu-Mi; Kang, Hyun-Mi; Lee, Sung-Churl; Yu, Jae-Won; Kil, Hong-Ryang; Rhim, Jung-Woo; Han, Ji-Whan; Lee, Kyung-Yil

    2018-05-01

    This study aimed to analyse laboratory values according to fever duration, and evaluate the relationship across these values during the acute phase of Kawasaki disease (KD) to aid in the early diagnosis for early-presenting KD and incomplete KD patients. Clinical and laboratory data of patients with KD (n=615) were evaluated according to duration of fever at presentation, and were compared between patients with and without coronary artery lesions (CALs). For evaluation of the relationships across laboratory indices, patients with a fever duration of 5 days or 6 days were used (n=204). The mean fever duration was 6.6±2.3 days, and the proportions of patients with CALs was 19.3% (n=114). C-reactive proteins (CRPs) and neutrophil differential values were highest and hemoglobin, albumin, and lymphocyte differential values were lowest in the 6-day group. Patients with CALs had longer total fever duration, higher CRP and neutrophil differential values and lower hemoglobin and albumin values compared to patients without CALs. CRP, albumin, neutrophil differential, and hemoglobin values at the peak inflammation stage of KD showed positive or negative correlations each other. The severity of systemic inflammation in KD was reflected in the laboratory values including CRP, neutrophil differential, albumin, and hemoglobin. Observing changes in these laboratory parameters by repeated examinations prior to the peak of inflammation in acute KD may aid in diagnosis of early-presenting KD patients.

  14. [South American camelids in Switzerland. II. Reference values for blood parameters].

    Science.gov (United States)

    Hengrave Burri, I; Tschudi, P; Martig, J; Liesegang, A; Meylan, M

    2005-08-01

    In order to establish reference values for blood parameters of South American camelids in Switzerland, 273 blood samples were collected from 141 llamas and 132 alpacas. These animals were classified in three categories (young animals blood cell count, white blood cell count, electrolytes, metabolites and enzymes). Significant differences between llamas and alpacas were evident for 26 parameters. This study also showed that differences between young animals, females and males must be taken into consideration. A comparison of blood values with the results of fecal analysis for parasite eggs showed that an infestation with Dicrocoelium dendriticum was associated with elevated activity of two liver enzymes (GLDH and gamma-GT) in the serum. In contrast, no differences were found in the results of blood analyses between animals shedding eggs of gastrointestinal strongyles or not.

  15. INFLUENCE OF ROLLING STOCK VIBROACOUSTICAL PARAMETERS ON THE CHOICE OF RATIONAL VALUES OF LOCOMOTIVE RUNNING GEAR

    Directory of Open Access Journals (Sweden)

    Yu. V. Zelenko

    2016-06-01

    Full Text Available Purpose.The success of the traffic on the railways of Ukraine depends on the number and the operational fleet of electric locomotives. Today, the locomotive depot exploit physically and morally outdated locomotives that have low reliability. Modernization of electric locomotives is not economically justified. The aim of this study is to improve the safety of the traction rolling stock by the frequency analysis of dynamical systems, which allows conducting the calculation of the natural (of resonant frequencies of the design and related forms of vibrations.Methodology.The study was conducted by methods of analytical mechanics and mathematical modeling of operating loads of freight locomotive when driving at different speeds on the straight and curved track sections. The theoretical value of the work is the technique of choice of constructive schemes and rational parameters of perspective electric locomotive taking into account the electric inertia ratios and stiffness coefficients of Lagrange second-order equations.Findings. The problems of theoretical research and the development of a mathematical model of the spatial electric vibrations are solved. The theoretical studies of the effect of inertia ratios and stiffness coefficients on the dynamic values and the parameter values of electric locomotive undercarriages are presented.Originality.The set of developed regulations and obtained results is a practical solution to selecting rational parameters of bogies of the freight mainline locomotive for railways of Ukraine. A concept of choice of constructive scheme and rational parameters of perspective locomotive is formulated. It is developed the method of calculation of spatial electric locomotive oscillations to determine its dynamic performance. The software complex for processing the data of experimental studies of dynamic parameters of electric locomotive and comparing the results of the theoretical calculations with the data of full

  16. Positive solutions for a nonlinear periodic boundary-value problem with a parameter

    Directory of Open Access Journals (Sweden)

    Jingliang Qiu

    2012-08-01

    Full Text Available Using topological degree theory with a partially ordered structure of space, sufficient conditions for the existence and multiplicity of positive solutions for a second-order nonlinear periodic boundary-value problem are established. Inspired by ideas in Guo and Lakshmikantham [6], we study the dependence of positive periodic solutions as a parameter approaches infinity, $$ lim_{lambdao +infty}|x_{lambda}|=+infty,quadhbox{or}quad lim_{lambdao+infty}|x_{lambda}|=0. $$

  17. Analysis of the value recommended by the NCRP 151 and its relationship with Brazilian parameters

    International Nuclear Information System (INIS)

    Groppo, Daniela P.; Martins, Homero L.

    2009-01-01

    The methodology proposed by the National Council on Radiation Protection 151 (NCRP 151), relates technical information necessary to structural shielding design and evaluation for megavoltage X- and gamma- ray radiotherapy facilities. However, many parameters used to calculate the shield are based on estimates, and may not be adequate to the Brazilian reality. Thus, the central idea of this study is to obtain parameters and is to outline a profile closer to the treatments carried out in facilities in Brazil, through a data collection routine of the Department of Radiotherapy Service of the Real e Benemerita Associacao Portuguesa de Beneficencia, in particular the cobalt therapy Theratron 780 (Atomic Energy of Canada Ltd.) and the linear accelerator Varian Clinac 2100C for measurement of workload, use factor, number of patients, fields, dose and anatomic region treated. So, the work did not draw definite values of the parameters, but indicative values were obtained which showed the importance to carry out more detailed studies of the recommended values. (author)

  18. The influence of the maximal value and peak enhancement value of arterial and venous enhancement curve on CT perfusion parameters and signal-to-noise ratio

    International Nuclear Information System (INIS)

    Ju Haiyue; Gao Sijia; Xu Ke; Wang Qiang

    2007-01-01

    Objective: To explore the influence of the maximal value and peak enhancement value of arterial and venous enhancement curve on CT perfusion parameters and signal-to-noise ratio (SNR). Methods: Seventeen patients underwent brain CT perfusion scanning. All row data were analyzed with perfusion software for 6 times, and get different arterial and venous enhancement curves for each patient. The maximal values and peak enhancement values of each arterial and venous enhancement curves, as well as mean perfusion parameters including cerebral blood flow (CBF), cerebral blood volume (CBV), mean transit time (MTT), permeability surface area product (PS), and their standard deviations (SD) in homolateral white and gray matter were measured and recorded. SNR was calculated by dividing the mean perfusion parameter value by its SD. Pearson correlation analysis and two-tailed paired Student t test were used for statistics. Results: The maximal values and peak enhancement values of arterial and venous curves were correlated with mean SNR CBF , SNR CBV and SNR MTT in both white matter and gray matters (r value range: 0.332-0.922, P PS in white matter(r=0.256, P PS (in both white matter and gray matters) and arterial peak enhancement values, the maximal values and venous peak enhancement values, or between SNR PS (in gray matter) and the maximal values of venous curve(r value range: -0.058-0.210, P>0.05). (2) Mean CBF, CBV and PS values in the group with low venous peak enhancement values were significantly different from the group with high venous peak enhancement values in both white and gray matters (t value range: 3.830-5.337, P 0.05). Conclusions: The mean perfusion parameters and SNR are influenced by the maximal values and peak enhancement values of the arterial and venous curves. Peak enhancement of arterial and venous curves should be adjusted to higher level to make parameter values more reliable and increase the SNR. (authors)

  19. Numerical solution of system of boundary value problems using B-spline with free parameter

    Science.gov (United States)

    Gupta, Yogesh

    2017-01-01

    This paper deals with method of B-spline solution for a system of boundary value problems. The differential equations are useful in various fields of science and engineering. Some interesting real life problems involve more than one unknown function. These result in system of simultaneous differential equations. Such systems have been applied to many problems in mathematics, physics, engineering etc. In present paper, B-spline and B-spline with free parameter methods for the solution of a linear system of second-order boundary value problems are presented. The methods utilize the values of cubic B-spline and its derivatives at nodal points together with the equations of the given system and boundary conditions, ensuing into the linear matrix equation.

  20. Uncertainty analyses of the calibrated parameter values of a water quality model

    Science.gov (United States)

    Rode, M.; Suhr, U.; Lindenschmidt, K.-E.

    2003-04-01

    For river basin management water quality models are increasingly used for the analysis and evaluation of different management measures. However substantial uncertainties exist in parameter values depending on the available calibration data. In this paper an uncertainty analysis for a water quality model is presented, which considers the impact of available model calibration data and the variance of input variables. The investigation was conducted based on four extensive flowtime related longitudinal surveys in the River Elbe in the years 1996 to 1999 with varying discharges and seasonal conditions. For the model calculations the deterministic model QSIM of the BfG (Germany) was used. QSIM is a one dimensional water quality model and uses standard algorithms for hydrodynamics and phytoplankton dynamics in running waters, e.g. Michaelis Menten/Monod kinetics, which are used in a wide range of models. The multi-objective calibration of the model was carried out with the nonlinear parameter estimator PEST. The results show that for individual flow time related measuring surveys very good agreements between model calculation and measured values can be obtained. If these parameters are applied to deviating boundary conditions, substantial errors in model calculation can occur. These uncertainties can be decreased with an increased calibration database. More reliable model parameters can be identified, which supply reasonable results for broader boundary conditions. The extension of the application of the parameter set on a wider range of water quality conditions leads to a slight reduction of the model precision for the specific water quality situation. Moreover the investigations show that highly variable water quality variables like the algal biomass always allow a smaller forecast accuracy than variables with lower coefficients of variation like e.g. nitrate.

  1. The influence of physical exertion on basic hematological parameters values and heart rate in trotters

    Directory of Open Access Journals (Sweden)

    Slijepčević Dajana

    2014-01-01

    Full Text Available One of very important prerequisites for achieving good results in races, in addition to genetic predisposition, quality training and good health, are optimal values for number of erythrocytes, concentration of haemoglobin and hematocrit, of which depends efficient oxygen supply of muscles during great efforts. The stated values, along with data on heart rate, are useful indicators of the degree of horse fitness and readiness for horse race. The influence of physical exertion on the values of basic hematological parameters as well as on heart rate, was investigated on 6 trotters, in training at the Belgrade racetrack (one head of Italian trotter, male, 3 years old; 3 heads of American trotter, male, 3,4 and 6 years old and two heads of Serbian trotter, female, 4 and 5 years old. The blood samples for hematological tests were taken by punction of jugular vein in resting phase - immediately before the commencement of work, after light trot warming for 3000 m and fast trot for 1000 m, with 30 minutes rest between the two runnings. The heart rate was monitored continuously by radio telemetry cardiometer, from the moment they were taken from their boxes and harnessing to the completion of work. The obtained results confirm the relationship between the rise of heart rate and hematocrit values: maximal hematocrit values were determined after the first running (0.49±0.05, in regard to 0.42±0.03 in resting phase, but 30 minutes after the second running there was a slight drop of hematocrit values (0.46±0.04. The blood samples in both cases were taken after fast trot during which there were recorded maximal pulse values, so in the moment of sampling the pulse lowered close to the values in resting - after the first running from 192.23±19.66, and after the second from 180.33±17.22 to 40.67±5.76.

  2. Heart rate variability enhances the prognostic value of established parameters in patients with congestive heart failure.

    Science.gov (United States)

    Krüger, C; Lahm, T; Zugck, C; Kell, R; Schellberg, D; Schweizer, M W F; Kübler, W; Haass, M

    2002-12-01

    This prospective study evaluated whether heart rate variability (HRV) assessed from Holter ECG has prognostic value in addition to established parameters in patients with congestive heart failure (CHF). The study included 222 patients with CHF due to dilated or ischemic cardiomyopathy (left ventricular ejection fraction LVEF 21+/-1%; mean+/-SEM). During a mean follow-up of 15+/-1 months, 38 (17%) patients died and 45 (20%) were hospitalized due to worsening of CHF. The HRV parameter SDNN (standard deviation of all intervals between normal beats) was significantly lower in non-surviving or hospitalized than in event-free patients (118+/-6 vs 142+/-5 ms), as were LVEF (18+/-1 vs 23+/-1%), and peak oxygen uptake during exercise (peak VO(2)) (12.8+/-0.5 vs 15.6+/-0.5 ml/min/kg). While each of these parameters was a risk predictor in univariate analysis, multivariate analysis revealed that HRV provides both independent and additional prognostic information with respect to the risk 'cardiac mortality or deterioration of CHF'. It is concluded that the determination of HRV enhances the prognostic power given by the most widely used parameters LVEF and peak VO(2) in the prediction of mortality or deterioration of CHF and thus enables to improve risk stratification.

  3. Prognostic value of Poincare plot as nonlinear parameter of chaos theory in patients with myocardial infarction

    Directory of Open Access Journals (Sweden)

    Milovanović Branislav

    2007-01-01

    Full Text Available Introduction: There are different proofs about association of autonomic nervous system dysfunction, especially nonlinear parameters, with higher mortality after myocardial infarction. Objective The objective of the study was to determine predictive value of Poincare plot as nonlinear parameter and other significant standard risk predictors: ejection fraction of the left ventricle, late potentials, ventricular arrhythmias, and QT interval. Method The study included 1081 patients with mean follow up of 28 months (ranging fom 0-80 months. End-point of the study was cardiovascular mortality. The following diagnostic methods were used during the second week: ECG with commercial software Schiller AT-10: short time spectral analysis of RR variability with analysis of Poincare plot as nonlinear parameter and late potentials; 24-hour ambulatory ECG monitoring: QT interval, RR interval, QT/RR slope, ventricular arrhythmias (Lown >II; echocardiography examinations: systolic disorder (defined as EF<40 %. Results There were 103 (9.52% cardiovascular deaths during the follow-up. In univariate analysis, the following parameters were significantly correlated with mortality: mean RR interval < 800 ms, QT and RR interval space relationship as mean RR interval < 800 ms and QT interval > 350 ms, positive late potentials, systolic dysfunction, Poincare plot as a point, ventricular arrhythmias (Lown > II. In multivariate analysis, the significant risk predictors were: Poincare plot as a point and mean RR interval lower than 800 ms. Conclusion Mean RR interval lower than 800 ms and nonlinear and space presentation of RR interval as a point Poincare plot were multivariate risk predictors.

  4. Average values of 235U resonance parameters up to 500 eV

    International Nuclear Information System (INIS)

    Leal, L.C.

    1991-01-01

    An R-matrix analysis of 235 U neutron cross sections was recently completed. The analysis was performed with the multilevel-multichannel Reich-Moore computer code SAMMY and extended the resolved resonance region up to 500 eV. Several high resolution measurements namely, transmission, fission and capture data as well as spin separated fission data were analyzed in a consistent manner and a very accurate parametrization up to 500 eV of these data were obtained. The aim of this paper is to present the results of average values of the resonance parameters. 9 refs., 1 tab

  5. Focusing of high power ultrasound beams and limiting values of shock wave parameters

    Science.gov (United States)

    Bessonova, O. V.; Khokhlova, V. A.; Bailey, M. R.; Canney, M. S.; Crum, L. A.

    2009-10-01

    In this work, the influence of nonlinear and diffraction effects on amplification factors of focused ultrasound systems is investigated. The limiting values of acoustic field parameters obtained by focusing of high power ultrasound are studied. The Khokhlov-Zabolotskaya-Kuznetsov (KZK) equation was used for the numerical modeling. Solutions for the nonlinear acoustic field were obtained at output levels corresponding to both pre- and post-shock formation conditions in the focal area of the beam in a weakly dissipative medium. Numerical solutions were compared with experimental data as well as with known analytic predictions.

  6. Water saturation in shaly sands: logging parameters from log-derived values

    International Nuclear Information System (INIS)

    Miyairi, M.; Itoh, T.; Okabe, F.

    1976-01-01

    The methods are presented for determining the relation of porosity to formation factor and that of true resistivity of formation to water saturation, which were investigated through the log interpretation of one of the oil and gas fields of northern Japan Sea. The values of the coefficients ''a'' and ''m'' in porosity-formation factor relation are derived from cross-plot of porosity and resistivity of formation corrected by clay content. The saturation exponent ''n'' is determined from cross-plot of porosity and resistivity index on the assumption that the product of porosity and irreducible water saturation is constant. The relation of porosity to irreducible water saturation is also investigated from core analysis. The new logging parameters determined from the methods, a = 1, m = 2, n = 1.4, improved the values of water saturation by 6 percent in average, and made it easy to distinguish the points which belong to the productive zone and ones belonging to the nonproductive zone

  7. Reconciling Planck with the local value of H0 in extended parameter space

    Directory of Open Access Journals (Sweden)

    Eleonora Di Valentino

    2016-10-01

    Full Text Available The recent determination of the local value of the Hubble constant by Riess et al., 2016 (hereafter R16 is now 3.3 sigma higher than the value derived from the most recent CMB anisotropy data provided by the Planck satellite in a ΛCDM model. Here we perform a combined analysis of the Planck and R16 results in an extended parameter space, varying simultaneously 12 cosmological parameters instead of the usual 6. We find that a phantom-like dark energy component, with effective equation of state w=−1.29−0.12+0.15 at 68% c.l. can solve the current tension between the Planck dataset and the R16 prior in an extended ΛCDM scenario. On the other hand, the neutrino effective number is fully compatible with standard expectations. This result is confirmed when including cosmic shear data from the CFHTLenS survey and CMB lensing constraints from Planck. However, when BAO measurements are included we find that some of the tension with R16 remains, as also is the case when we include the supernova type Ia luminosity distances from the JLA catalog.

  8. Parameter values for the estimation of radionuclide transfer to major food crops in Korea

    International Nuclear Information System (INIS)

    Choi, Yong-Ho; Lim, Kwang-Muk; Jun, In; Keum, Dong-Kwon; Lee, Chang-Woo

    2008-01-01

    This paper summarizes the results of the radiotracer experiments and field studies performed in Korea for the past 20 years to obtain parameter values for estimating the environmental transfer of radionuclides to food crops. With regards to direct plant contamination, the interception fractions, weathering half-lives and translocation factors of Cs, Sr, Mn, Co and Ru were measured for depositions at different growth stages of selected food crops. In order to investigate an indirect contamination pathway, the soil-to-plant transfer factors (TF m , dimensionless) of Cs, Sr, Mn, Co and/or Zn were measured for rice, Chinese cabbage, radish, soybean, barley, lettuce and so on in one or more soils. In addition, the transfer factors (TF a , m 2 kg -1 ) based on a deposition density were also measured following depositions at different times during the growth periods of several food crops. Particularly for rice and Chinese cabbage, tritium experiments were also carried out for the TF a . The obtained parameter values varied considerably with the soils, crops, radionuclides and deposition times. These data would be applicable to both normal and acute releases not only in Korea but also in many other countries. (author)

  9. Influence of puerperal gonadoreline application on reproductive parameter values in cows

    Directory of Open Access Journals (Sweden)

    Šabanović Mustafa

    2006-01-01

    Full Text Available This paper presents results of investigations conducted in order to investigate the influence of gonadoreline application 14-16, 17-20 and 21-25 days postpartum on reproductive parameters values in cows. A total of 241 cows was included in the study. Out of this number, 126 cows were treated with gonadoreline while 115 animals were placebo treated and served as controls. The estimation of progesterone concentration was conducted on 43 animals selected randomly from the first two groups of treated cows. Analyses of the results in cows that gave normal birth, revealed that mean anoestrus period, open day's period and intervals between calving were significantly lower in the gonadoreline treated groups. Reproductive parameter values in cows with different progesterone concentrations did not differ significantly. The period from gonadoreline application until conception, was shorter by 30, 30 and 14 days, respectively, compared to the controls. The total conception rate from the first three artificial inseminations was 88. 8% in gonadoreline treated groups and 83.47 % in the control groups.

  10. Influence of lung parameter values for the Brazilian population on inhalation dose

    International Nuclear Information System (INIS)

    Reis, Arlene A.; Lopes, Ricardo T.

    2009-01-01

    The Human Respiratory Tract Model (HRTM) proposed by the ICRP Publication 66 accounts for the morphology and physiology of the respiratory tract. The ICRP 66 presents deposition fraction in the respiratory tract regions considering reference values from Caucasian man. However, in order to obtain a more accurate assessment of intake and dose the ICRP recommends the use of specific information when they are available. The main objective of this study is to evaluate the influence in dose calculation to each region of the respiratory tract when physiological parameters from samples of Brazilian population, in different levels of exercise, are applied in the deposition model.The dosimetric model of HRTM was implemented in the software EXCEL for Windows and committed equivalent dose was determined for each respiratory tract region. First it was calculated the total number of nuclear transformations considering the fractional deposition of activity in each source tissue obtained by application of physiological and morphological Brazilian parameters in the deposition model and then it was calculated the total energy absorbed per unit mass in the target tissue.The variation in the fractional deposition in the compartments of the respiratory tract in changing the physiological parameters from Caucasian to Brazilian adult man causes variation in the number of total transformations and also in the equivalent dose in each region of the respiratory tract. The variations are not the same for all regions of the respiratory tract and depend on levels of exercise. (author)

  11. Commercial software upgrades may significantly alter Perfusion CT parameter values in colorectal cancer

    International Nuclear Information System (INIS)

    Goh, Vicky; Shastry, Manu; Endozo, Raymondo; Groves, Ashley M.; Engledow, Alec; Peck, Jacqui; Reston, Jonathan; Wellsted, David M.; Rodriguez-Justo, Manuel; Taylor, Stuart A.; Halligan, Steve

    2011-01-01

    To determine how commercial software platform upgrades impact on derived parameters for colorectal cancer. Following ethical approval, 30 patients with suspected colorectal cancer underwent Perfusion CT using integrated 64 detector PET/CT before surgery. Analysis was performed using software based on modified distributed parameter analysis (Perfusion software version 4; Perfusion 4.0), then repeated using the previous version (Perfusion software version 3; Perfusion 3.0). Tumour blood flow (BF), blood volume (BV), mean transit time (MTT) and permeability surface area product (PS) were determined for identical regions-of-interest. Slice-by-slice and 'whole tumour' variance was assessed by Bland-Altman analysis. Mean BF, BV and PS was 20.4%, 59.5%, and 106% higher, and MTT 14.3% shorter for Perfusion 4.0 than Perfusion 3.0. The mean difference (95% limits of agreement) were +13.5 (-44.9 to 72.0), +2.61 (-0.06 to 5.28), -1.23 (-6.83 to 4.36), and +14.2 (-4.43 to 32.8) for BF, BV, MTT and PS respectively. Within subject coefficient of variation was 36.6%, 38.0%, 27.4% and 60.6% for BF, BV, MTT and PS respectively indicating moderate to poor agreement. Software version upgrades of the same software platform may result in significantly different parameter values, requiring adjustments for cross-version comparison. (orig.)

  12. Methodology for determining the value of complexity parameter for emergency situation during driving of the train

    Directory of Open Access Journals (Sweden)

    O. M. Horobchenko

    2015-12-01

    Full Text Available Purpose. During development of intelligent control systems for locomotive there is a need in the evaluation of the current train situation in the terms of traffic safety. In order to estimate the probability of the development of various emergency situations in to the traffic accidents, it is necessary to determine their complexity. The purpose of this paper is to develop the methodology for determining the complexity of emergency situations during the locomotive operation. Methodology. To achieve this purpose the statistical material of traffic safety violations was accumulated. The causes of violations are divided into groups: technical factors, human factors and external influences. Using the theory of hybrid networks it was obtained a model that gives the output complexity parameter of the emergency situation. Network type: multilayer perceptron with hybrid neurons of the first layer and the sigmoid activation function. The methods of the probability theory were used for the analysis of the results. Findings. The approach to the formalization of manufacturing situations that can only be described linguistically was developed, that allowed to use them as input data to the model for emergency situation. It was established and proved that the exponent of complexity for emergency situation during driving the train is a random quantity and obeys to the normal distribution law. It was obtained the graph of the cumulative distribution function, which identified the areas for safe operation and an increased risk of accident. Originality. It was proposed theoretical basis for determining the complexity of emergency situations in the train work and received the maximum complexity value of emergency situations that can be admitted in the operating conditions. Practical value. Constant monitoring of this value allows not only respond to the threat of danger, but also getting it in numerical form and use it as one of the input parameters for the

  13. The method of extraction of subspectra with appreciably different values of hyperfine interaction parameters from Moessbauer spectra

    International Nuclear Information System (INIS)

    Nemtsova, O.M.

    2006-01-01

    The task of Moessbauer spectra processing of complex locally inhomogeneous or multi-phase systems is to reveal subspectral contributions with appreciably different values of hyperfine interaction parameters (HFI) in them. A universal method of processing such spectra is suggested which allows to extract the probability density distribution (PDD) of HFI parameters corresponding to the subspectra with essentially different parameters values. The basis of the method is Tikhonov's regularization method with selection for each subspectrum its own value of the regularization parameter. The universal application of the method is demonstrated in the examples of processing real spectra with different sets of subspectral contributions

  14. Intravoxel incoherent motion diffusion imaging of the liver: Optimal b-value subsampling and impact on parameter precision and reproducibility

    International Nuclear Information System (INIS)

    Dyvorne, Hadrien; Jajamovich, Guido; Kakite, Suguru; Kuehn, Bernd; Taouli, Bachir

    2014-01-01

    Highlights: • We assess the precision and reproducibility of liver IVIM diffusion parameters. • Liver IVIM DWI can be performed with 4 b-values with good parameter precision. • Liver IVIM DWI can be performed with 4 b-values with good parameter reproducibility. - Abstract: Purpose: To increase diffusion sampling efficiency in intravoxel incoherent motion (IVIM) diffusion-weighted imaging (DWI) of the liver by reducing the number of diffusion weightings (b-values). Materials and methods: In this IRB approved HIPAA compliant prospective study, 53 subjects (M/F 38/15, mean age 52 ± 13 y) underwent IVIM DWI at 1.5 T using 16 b-values (0–800 s/mm 2 ), with 14 subjects having repeat exams to assess IVIM parameter reproducibility. A biexponential diffusion model was used to quantify IVIM hepatic parameters (PF: perfusion fraction, D: true diffusion and D*: pseudo diffusion). All possible subsets of the 16 b-values were probed, with number of b values ranging from 4 to 15, and corresponding parameters were quantified for each subset. For each b-value subset, global parameter estimation error was computed against the parameters obtained with all 16 b-values and the subsets providing the lowest error were selected. Interscan estimation error was also evaluated between repeat exams to assess reproducibility of the IVIM technique in the liver. The optimal b-values distribution was selected such that the number of b-values was minimal while keeping parameter estimation error below interscan reproducibility error. Results: As the number of b-values decreased, the estimation error increased for all parameters, reflecting decreased precision of IVIM metrics. Using an optimal set of 4 b-values (0, 15, 150 and 800 s/mm 2 ), the errors were 6.5, 22.8 and 66.1% for D, PF and D* respectively. These values lie within the range of test–retest reproducibility for the corresponding parameters, with errors of 12.0, 32.3 and 193.8% for D, PF and D* respectively. Conclusion: A set

  15. Application of extreme value distribution function in the determination of standard meteorological parameters for nuclear power plants

    International Nuclear Information System (INIS)

    Jiang Haimei; Liu Xinjian; Qiu Lin; Li Fengju

    2014-01-01

    Based on the meteorological data from weather stations around several domestic nuclear power plants, the statistical results of extreme minimum temperatures, minimum. central pressures of tropical cyclones and some other parameters are calculated using extreme value I distribution function (EV- I), generalized extreme value distribution function (GEV) and generalized Pareto distribution function (GP), respectively. The influence of different distribution functions and parameter solution methods on the statistical results of extreme values is investigated. Results indicate that generalized extreme value function has better applicability than the other two distribution functions in the determination of standard meteorological parameters for nuclear power plants. (authors)

  16. Diagnostic efficacy for coronary in-stent patency with parameters defined on Hounsfield CT value-spatial profile curves

    International Nuclear Information System (INIS)

    Yamazaki, Tadashi; Suzuki, Jun-ichi; Shimamoto, Ryoichi; Tsuji, Taeko; Ohmoto-Sekine, Yuki; Morita, Toshihiro; Yamashita, Hiroshi; Honye, Junko; Nagai, Ryozo; Komatsu, Shuhei; Akahane, Masaaki; Ohtomo, Kuni

    2008-01-01

    Purpose: Hounsfield CT values across coronary CT angiograms constitute CT value-spatial profile curves. These CT profile curves are independent of window settings, and therefore, parameters derived from the curves can be used for objective anatomic analyses. Applicability of parameters derived from the curves to quantification of coronary in-stent patency has not yet been evaluated. Methods: Twenty-five CT value-spatial profile curves were delineated from 10 consecutive coronary stents to test correlation between the curve derived parameter (i.e., the minimum extreme value normalized by dividing by the maximum value of the curves obtained at neighboring outside of stents) and three intravascular ultrasound (IVUS) parameters. Results: Correlation coefficients between normalized minimum extreme value of CT value-spatial profile curves and three IVUS parameters (such as patent cross-sectional in-stent area, the percentage of patent cross-sectional in-stent area, and coronary artery intra-stent diameter) were 0.65 (p < 0.01), 0.44 (p < 0.05) and 0.51 (p < 0.05), respectively. Conclusions: CT parameters defined on Hounsfield CT value-spatial profile curves correlated significantly with IVUS parameters for quantitative coronary in-stent patency. A new approach with CT coronary angiography is therefore indicated for the noninvasive assessment of in-stent re-stenosis

  17. Synopses/physical significance of complex-valued catalyst parameters in heterogeneous catalysis

    Energy Technology Data Exchange (ETDEWEB)

    Hesse, D

    1979-08-01

    An independent parameter was used to describe the local values of the interdependent thermodynamic variables of the coupled effects of transfer, sorption, and surface reaction at steady state in a packed bed of porous catalyst. A system reduction yielded a generalized concept of the pore effectiveness factor, H, which was unity or a real or imaginary complex number when the coupled diffusion and reaction processes do not affect, inhibit, or enhance conversion, respectively. These concepts are illustrated by ethylene hydrogenation on platinum, a process in which ethylene adsorbs much more strongly than hydrogen, but diffuses more slowly; as the rate is proportional to the product of hydrogen and ethylene surface coverage and the more strongly adsorbed ethylene occupies the majority of the available sites, a decrease in gas-phase ethylene concentration would increase the conversion rate. The reaction rate also increases with decreasing distance from the catalyst particle core.

  18. The EURISOL Beta-beam Facility: Parameter and Intensity Values, Version 2

    CERN Document Server

    Benedikt, M; Lindroos, M; Fabich, A

    An initial “bottom-up” analysis of ion intensities along the accelerator chain is revised to take into account more recent simulations of the stacking of 18Ne ions in the decay ring and beneficial trends in output flux as functions of certain machine parameters. In addition, space charge detuning at injection in the PS has led to a rethink of the top energy of the RCS, while that at injection in the SPS has had an impact on the number of bunches per batch delivered by the PS. We present transverse emittance values (which enter the space charge tune shift calculations) together with an updated list of intensities for both ion species under consideration in the baseline scenario.

  19. Weak-value amplification and optimal parameter estimation in the presence of correlated noise

    Science.gov (United States)

    Sinclair, Josiah; Hallaji, Matin; Steinberg, Aephraim M.; Tollaksen, Jeff; Jordan, Andrew N.

    2017-11-01

    We analytically and numerically investigate the performance of weak-value amplification (WVA) and related parameter estimation methods in the presence of temporally correlated noise. WVA is a special instance of a general measurement strategy that involves sorting data into separate subsets based on the outcome of a second "partitioning" measurement. Using a simplified correlated noise model that can be analyzed exactly together with optimal statistical estimators, we compare WVA to a conventional measurement method. We find that WVA indeed yields a much lower variance of the parameter of interest than the conventional technique does, optimized in the absence of any partitioning measurements. In contrast, a statistically optimal analysis that employs partitioning measurements, incorporating all partitioned results and their known correlations, is found to yield an improvement—typically slight—over the noise reduction achieved by WVA. This result occurs because the simple WVA technique is not tailored to any specific noise environment and therefore does not make use of correlations between the different partitions. We also compare WVA to traditional background subtraction, a familiar technique where measurement outcomes are partitioned to eliminate unknown offsets or errors in calibration. Surprisingly, for the cases we consider, background subtraction turns out to be a special case of the optimal partitioning approach, possessing a similar typically slight advantage over WVA. These results give deeper insight into the role of partitioning measurements (with or without postselection) in enhancing measurement precision, which some have found puzzling. They also resolve previously made conflicting claims about the usefulness of weak-value amplification to precision measurement in the presence of correlated noise. We finish by presenting numerical results to model a more realistic laboratory situation of time-decaying correlations, showing that our conclusions hold

  20. Standardized uptake value in pediatric patients: an investigation to determine the optimum measurement parameter

    International Nuclear Information System (INIS)

    Yeung, H.W.; Squire, O.D.; Larson, S.M.; Erdi, Y.E.; Sanches, A.; Macapinlac, H.A.

    2002-01-01

    Although the standardized uptake value (SUV) is currently used in fluorine-18 fluorodeoxyglucose positron emission tomography (FDG-PET) imaging, concerns have been raised over its accuracy and clinical relevance. Dependence of the SUV on body weight has been observed in adults and this should be of concern in the pediatric population, since there are significant body changes during childhood. The aim of the present study was to compare SUV measurements based on body weight, body surface area and lean body mass in the pediatric population and to determine a more reliable parameter across all ages. Sixty-eight pediatric FDG-PET studies were evaluated. Age ranged from 2 to 17 years and weight from 11 to 77 kg. Regions of interest were drawn at the liver for physiologic comparison and at FDG-avid malignant lesions. SUV based on body weight (SUV bw ) varied across different weights, a phenomenon less evident when body surface area (SUV bsa ) normalization is applied. Lean body mass-based SUV (SUV lbm ) also showed a positive correlation with weight, which again was less evident when normalized to bsa (SUV bsa-lbm ). The measured liver SUV bw was 1.1±0.3, a much lower value than in our adult population (1.9±0.3). The liver SUV bsa was 7.3±1.3. The tumor sites had an SUV bw of 4.0±2.7 and an SUV bsa of 25.9±15.4 (65% of the patients had neuroblastoma). The bsa-based SUVs were more constant across the pediatric ages and were less dependent on body weight than the SUV bw . These results indicate that SUV calculated on the basis of body surface area is a more uniform parameter than SUV based on body weight in pediatric patients and is probably the most appropriate approach for the follow-up of these patients. (orig.)

  1. Comparison of the prognostic values of preoperative inflammation-based parameters in patients with breast cancer.

    Directory of Open Access Journals (Sweden)

    Hideya Takeuchi

    Full Text Available Peripheral blood-derived inflammation-based markers, including C-reactive protein (CRP, neutrophil-to-lymphocyte ratio (NLR, lymphocyte-to-monocyte ratio (LMR, and platelet-to-lymphocyte ratio (PLR are indicators of prognosis in various malignant tumors. The present study aimed to identify the inflammation-based parameters that are most suitable for predicting outcomes in patients with breast cancer. Two hundred ninety-six patients who underwent surgery for localized breast cancer were reviewed retrospectively. The association between clinicopathological factors and inflammation-based parameters were investigated. Univariate and multivariate Cox regression analyses were performed to identify independent prognostic indicators associated with disease-free survival (DFS. The NLR level correlated significantly with tumor size (P<0.05. The PLR level correlated with the expression of estrogen receptor and lymph node involvement (P<0.05. Univariate analysis revealed that lower CRP and PLR values as well as tumor size, lymph node involvement, and nuclear grade were significantly associated with superior DFS (CRP: P<0.01; PLR, tumor size, lymph node involvement, and nuclear grade: P<0.05. On multivariate analysis, CRP (hazard ratio [HR]: 2.85, 95% confidence interval [CI]: 1.03-7.88, P<0.05, PLR (HR: 2.61, 95% CI: 1.07-6.36, P<0.05 and nuclear grade (HR: 3.066, 95% CI: 1.26-7.49, P<0.05 were significant prognostic indicators of DFS in patients with breast cancer. Neither LMR nor NLR significantly predicted DFS. Both preoperative CRP and PLR values were independently associated with poor prognosis in patients with breast carcinoma; these were superior to other inflammation-based scores in terms of prognostic ability.

  2. Revisiting linear plasma waves for finite value of the plasma parameter

    Science.gov (United States)

    Grismayer, Thomas; Fahlen, Jay; Decyk, Viktor; Mori, Warren

    2010-11-01

    We investigate through theory and PIC simulations the Landau-damping of plasma waves with finite plasma parameter. We concentrate on the linear regime, γφB, where the waves are typically small and below the thermal noise. We simulate these condition using 1,2,3D electrostatic PIC codes (BEPS), noting that modern computers now allow us to simulate cases where (nλD^3 = [1e2;1e6]). We study these waves by using a subtraction technique in which two simulations are carried out. In the first, a small wave is initialized or driven, in the second no wave is excited. The results are subtracted to provide a clean signal that can be studied. As nλD^3 is decreased, the number of resonant electrons can be small for linear waves. We show how the damping changes as a result of having few resonant particles. We also find that for small nλD^3 fluctuations can cause the electrons to undergo collisions that eventually destroy the initial wave. A quantity of interest is the the life time of a particular mode which depends on the plasma parameter and the wave number. The life time is estimated and then compared with the numerical results. A surprising result is that even for large values of nλD^3 some non-Vlasov discreteness effects appear to be important.

  3. Predictive value of some hematological parameters for non-invasive and invasive mole pregnancies.

    Science.gov (United States)

    Abide Yayla, Cigdem; Özkaya, Enis; Yenidede, Ilter; Eser, Ahmet; Ergen, Evrim Bostancı; Tayyar, Ahter Tanay; Şentürk, Mehmet Baki; Karateke, Ates

    2018-02-01

    The aim of this study was to discriminate mole pregnancies and invasive forms among cases with first trimester vaginal bleeding by the utilization of some complete blood count parameters conjunct to sonographic findings and beta human chorionic gonadotropin concentration. Consecutive 257 cases with histopathologically confirmed mole pregnancies and 199 women without mole pregnancy presented with first trimester vaginal bleeding who admitted to Zeynep Kamil Women and Children's Health Training Hospital between January 2012 and January 2016 were included in this cross-sectional study. The serum beta HCG level at presentation, and beta hCG levels at 1st, 2nd and 3rd weeks of postevacuation with some parameters of complete blood count were utilized to discriminate cases with molar pregnancy and cases with invasive mole among first trimester pregnants presented with vaginal bleeding and abnormal sonographic findings. Levels of beta hCG at baseline (AUC = 0.700, p < 0.05) and 1st (AUC = 0.704, p < 0.05), 2nd (AUC = 0.870, p < 0.001) and 3rd (AUC = 0.916, p < 0.001) weeks of postevacuation period were significant predictors for the cases with persistent disease. While area under curve for mean platelet volume is 0.715, it means that mean platelet volume has 21.5% additional diagnostic value for predicting persistency in molar patients. For 8.55 cut-off point for mean platelet volume, sensitivity is 84.6% and specificity is 51.6%. Area under curve for platelet/lymphocyte ratio is 0.683 means that platelet/lymphocyte ratio has additional 18.3% diagnostic value. For 102.25 cut-off point sensitivity is 86.6% and specificity is 46.2. Simple, widely available complete blood count parameters may be used as an adjunct to other risk factors to diagnose molar pregnancies and predict postevacuation trophoblastic disease.

  4. Baseline values of immunologic parameters in the lizard Salvator merianae (Teiidae, Squamata)

    Science.gov (United States)

    Mestre, Ana Paula; Amavet, Patricia Susana; Siroski, Pablo Ariel

    2017-01-01

    The genus Salvator is widely distributed throughout South America. In Argentina, the species most abundant widely distributed is Salvator merianae. Particularly in Santa Fe province, the area occupied by populations of these lizards overlaps with areas where agriculture was extended. With the aim of established baseline values for four immunologic biomarkers widely used, 36 tegu lizards were evaluated tacking into account different age classes and both sexes. Total leukocyte counts were not different between age classes. Of the leucocytes count, eosinophils levels were higher in neonates compared with juvenile and adults; nevertheless, the heterophils group was the most prevalent leukocyte in the peripheral blood in all age classes. Lymphocytes, monocytes, heterophils, azurophils and basophils levels did not differ with age. Natural antibodies titres were higher in the adults compared with neonates and juveniles lizards. Lastly, complement system activity was low in neonates compared with juveniles and adults. Statistical analysis within each age group showed that gender was not a factor in the outcomes. Based on the results, we concluded that S. merianae demonstrated age (but not gender) related differences in the immune parameters analyzed. Having established baseline values for these four widely-used immunologic biomarkers, ongoing studies will seek to optimize the use of the S. merianae model in future research. PMID:28652981

  5. Baseline values of immunologic parameters in the lizard Salvator merianae (Teiidae, Squamata).

    Science.gov (United States)

    Mestre, Ana Paula; Amavet, Patricia Susana; Siroski, Pablo Ariel

    2017-01-01

    The genus Salvator is widely distributed throughout South America. In Argentina, the species most abundant widely distributed is Salvator merianae . Particularly in Santa Fe province, the area occupied by populations of these lizards overlaps with areas where agriculture was extended. With the aim of established baseline values for four immunologic biomarkers widely used, 36 tegu lizards were evaluated tacking into account different age classes and both sexes. Total leukocyte counts were not different between age classes. Of the leucocytes count, eosinophils levels were higher in neonates compared with juvenile and adults; nevertheless, the heterophils group was the most prevalent leukocyte in the peripheral blood in all age classes. Lymphocytes, monocytes, heterophils, azurophils and basophils levels did not differ with age. Natural antibodies titres were higher in the adults compared with neonates and juveniles lizards. Lastly, complement system activity was low in neonates compared with juveniles and adults. Statistical analysis within each age group showed that gender was not a factor in the outcomes. Based on the results, we concluded that S. merianae demonstrated age (but not gender) related differences in the immune parameters analyzed. Having established baseline values for these four widely-used immunologic biomarkers, ongoing studies will seek to optimize the use of the S. merianae model in future research.

  6. Baseline values of immunologic parameters in the lizard Salvator merianae (Teiidae, Squamata

    Directory of Open Access Journals (Sweden)

    Ana Paula Mestre

    2017-05-01

    Full Text Available The genus Salvator is widely distributed throughout South America. In Argentina, the species most abundant widely distributed is Salvator merianae. Particularly in Santa Fe province, the area occupied by populations of these lizards overlaps with areas where agriculture was extended. With the aim of established baseline values for four immunologic biomarkers widely used, 36 tegu lizards were evaluated tacking into account different age classes and both sexes. Total leukocyte counts were not different between age classes. Of the leucocytes count, eosinophils levels were higher in neonates compared with juvenile and adults; nevertheless, the heterophils group was the most prevalent leukocyte in the peripheral blood in all age classes. Lymphocytes, monocytes, heterophils, azurophils and basophils levels did not differ with age. Natural antibodies titres were higher in the adults compared with neonates and juveniles lizards. Lastly, complement system activity was low in neonates compared with juveniles and adults. Statistical analysis within each age group showed that gender was not a factor in the outcomes. Based on the results, we concluded that S. merianae demonstrated age (but not gender related differences in the immune parameters analyzed. Having established baseline values for these four widely-used immunologic biomarkers, ongoing studies will seek to optimize the use of the S. merianae model in future research.

  7. Meaningfulness of Service and Marital Satisfaction in Army Couples

    Science.gov (United States)

    Bergmann, Jeffrey S.; Renshaw, Keith D.; Allen, Elizabeth S.; Markman, Howard J.; Stanley, Scott M.

    2015-01-01

    The vast numbers of military service members who have been deployed since 2001 highlights the need to better understand relationships of military couples. A unique consideration in military couples is the concept of meaningfulness of service, or the value service members and their partners place on military service in spite of the sacrifices it requires. In a sample of 606 Army couples, we used path analysis to examine how male service members’ and female spouses’ perceived meaningfulness of service added to the prediction of marital satisfaction in both members of the couple, when accounting for service members’ PTSD symptoms. Spouses’ perceived meaningfulness of service was linked with higher marital satisfaction in spouses, regardless of service member’s perceived meaningfulness of service. Service members’ perceived meaningfulness of service was also associated with increased marital satisfaction in service members, but only when their spouses also perceived higher meaningfulness. There were no significant interactions between service members’ PTSD and either partner’s perceived meaningfulness. Implications for enhanced attention to spousal perceptions of meaningfulness of service are discussed. PMID:25046347

  8. Meaningfulness of service and marital satisfaction in Army couples.

    Science.gov (United States)

    Bergmann, Jeffrey S; Renshaw, Keith D; Allen, Elizabeth S; Markman, Howard J; Stanley, Scott M

    2014-10-01

    The vast numbers of military service members who have been deployed since 2001 highlights the need to better understand relationships of military couples. A unique consideration in military couples is the concept of meaningfulness of service, or the value service members and their partners place on military service in spite of the sacrifices it requires. In a sample of 606 Army couples, the authors used path analysis to examine how male service members' and female spouses' perceived meaningfulness of service added to the prediction of marital satisfaction in both members of the couple, when accounting for service members' PTSD symptoms. Spouses' perceived meaningfulness of service was linked with higher marital satisfaction in spouses, regardless of service member's perceived meaningfulness of service. Service members' perceived meaningfulness of service was also associated with increased marital satisfaction in service members, but only when their spouses also perceived higher meaningfulness. There were no significant interactions between service members' PTSD and either partner's perceived meaningfulness. Implications for enhanced attention to spousal perceptions of meaningfulness of service are discussed. (PsycINFO Database Record (c) 2014 APA, all rights reserved).

  9. A critical look at the kinetic parameter values used in simulating the thermoluminescence glow-curve

    Energy Technology Data Exchange (ETDEWEB)

    Sadek, A.M., E-mail: dr_amrsadek@hotmail.com [Ionizing Radiation Metrology Department, National Institute for Standards, El-Haram, Giza (Egypt); Kitis, G. [Nuclear Physics and Elementary Particles Physics Section, Physics Department, Aristotle University of Thessaloniki, 54124 Thessaloniki, Makedonia (Greece)

    2017-03-15

    Objections against utilizing the peak fitting method in computing the kinetics parameters of thermoluminescence (TL) glow-peaks were discussed previously in the literature. These objections came through testing the accuracy of the peak fitting by applying on simulated peaks. The results showed that in some cases the simulated peaks may have unusual geometrical properties and do not reflect the real properties of TL peaks. Thereby, estimating the accuracy of the peak fitting by applying on such peaks would be misleading. Two main reasons may lead to unrealistic simulated peaks; the improper selection of the simulation inputs, and performing the TL simulation process via the heating stage only. It has been proved that considering the irradiation and the relaxation stages in the simulation process is crucial. However, there are other cases in which the analytical methods were not able to reveal the real values of the simulated peaks. These cases were successfully resolved using analytical expressions derived from the one trap-one recombination (OTOR) level model and the non-interactive multiple trap system (NMTS) model. A general conclusion can be drawn that the accuracy of the peak fitting method is critically dependent on the TL analytical expressions utilized in this method. The failure of this method in estimating the TL kinetic parameters should be attributed to the TL model equation utilized in fitting process. - Highlights: • Objections against using the TL peak fitting method are discussed. • Improper selection of simulation inputs may lead to non realistic TL peaks. • Considering the irradiation and the relaxation stages in simulation is crucial. • TL expressions could not describe TL peaks with unrealistic geometrical properties. • The accuracy of the peak fitting method depends on the model used in the fitting.

  10. Sickle cell disease: reference values and interhemispheric differences of nonimaging transcranial Doppler blood flow parameters.

    Science.gov (United States)

    Arkuszewski, M; Krejza, J; Chen, R; Kwiatkowski, J L; Ichord, R; Zimmerman, R; Ohene-Frempong, K; Desiderio, L; Melhem, E R

    2011-09-01

    TCD screening is widely used to identify children with SCD at high risk of stroke. Those with high mean flow velocities in major brain arteries have increased risk of stroke. Thus, our aim was to establish reference values of interhemispheric differences and ratios of blood flow Doppler parameters in the tICA, MCA, and ACA as determined by conventional TCD in children with sickle cell anemia. Reference limits of blood flow parameters were established on the basis of a consecutive cohort of 56 children (mean age, 100 ± 40 months; range, 29-180 months; 30 females) free of neurologic deficits and intracranial stenosis detectable by MRA, with blood flow velocities <170 cm/s by conventional TCD. Reference limits were estimated by using tolerance intervals, within which are included with a probability of .90 of all possible data values from 95% of a population. Average peak systolic velocities were significantly higher in the right hemisphere in the MCA and ACA (185 ± 28 cm/s versus 179 ± 27 and 152 ± 30 cm/s versus 143 ± 34 cm/s respectively). Reference limits for left-to-right differences in the mean flow velocities were the following: -43 to 33 cm/s for the MCA; -49 to 38 cm/s for the ACA, and -38 to 34 cm/s for the tICA, respectively. Respective reference limits for left-to-right velocity ratios were the following: 0.72 to 1.25 cm/s for the MCA; 0.62 to 1.39 cm/s for the ACA, and 0.69 to 1.27 cm/s for the tICA. Flow velocities in major arteries were inversely related to age and Hct or Hgb. The study provides reference intervals of TCD flow velocities and their interhemispheric differences and ratios that may be helpful in identification of intracranial arterial stenosis in children with SCD undergoing sonographic screening for stroke prevention.

  11. Generalized Extreme Value's shape parameter and its nature for extreme precipitation using long time series and Bayesian approach

    Science.gov (United States)

    Ragulina, Galina; Reitan, Trond

    2016-04-01

    Assessing the probability of extreme precipitation events is of great importance in civil planning. This requires understanding of how return values change with different return periods, which is essentially described by the Generalized Extreme Value distribution's shape parameter. Some works in the field have suggested a constant shape parameter, while our analysis indicates a non-universal value. We first re-analyse an older precipitation dataset (169 stations) extended by Norwegian data (71 stations). We show that while each set seems to have a constant shape parameter, it differs between the two datasets, indicating regional differences. For a more comprehensive analysis of spatial effects, we examine a global dataset (1495 stations). We provide shape parameter maps for two models. We find clear evidence for the shape parameter being dependent on elevation while the effect of latitude remains uncertain. Our results confirm an explanation in terms of dominating precipitation systems based on a proxy derived from the Köppen-Geiger climate classification.

  12. Genetic parameter and breeding value estimation of donkeys' problem-focused coping styles.

    Science.gov (United States)

    Navas González, Francisco Javier; Jordana Vidal, Jordi; León Jurado, José Manuel; Arando Arbulu, Ander; McLean, Amy Katherine; Delgado Bermejo, Juan Vicente

    2018-05-12

    Donkeys are recognized therapy or leisure-riding animals. Anecdotal evidence has suggested that more reactive donkeys or those more easily engaging flight mechanisms tend to be easier to train compared to those displaying the natural donkey behaviour of fight. This context brings together the need to quantify such traits and to genetically select donkeys displaying a neutral reaction during training, because of its implication with handler/rider safety and trainability. We analysed the scores for coping style traits from 300 Andalusian donkeys from 2013 to 2015. Three scales were applied to describe donkeys' response to 12 stimuli. Genetic parameters were estimated using multivariate models with year, sex, husbandry system and stimulus as fixed effects and age as a linear and quadratic covariable. Heritabilities were moderate, 0.18 ± 0.020 to 0.21 ± 0.021. Phenotypic correlations between intensity and mood/emotion or response type were negative and moderate (-0.21 and -0.25, respectively). Genetic correlations between the same variables were negative and moderately high (-0.46 and -0.53, respectively). Phenotypic and genetic correlations between mood/emotion and response type were positive and high (0.92 and 0.95, respectively). Breeding values enable selection methods that could lead to endangered breed preservation and genetically selecting donkeys for the uses that they may be most suitable. Copyright © 2018 Elsevier B.V. All rights reserved.

  13. Determination of sustainable values for the parameters of the construction of residential buildings

    Science.gov (United States)

    Grigoreva, Larisa; Grigoryev, Vladimir

    2018-03-01

    For the formation of programs for housing construction and planning of capital investments, when developing the strategic planning companies by construction companies, the norms or calculated indicators of the duration of the construction of high-rise residential buildings and multifunctional complexes are mandatory. Determination of stable values of the parameters for the high-rise construction residential buildings provides an opportunity to establish a reasonable duration of construction at the planning and design stages of residential complexes, taking into account the influence of market conditions factors. The concept of the formation of enlarged models for the high-rise construction residential buildings is based on a real mapping in time and space of the most significant redistribution with their organizational and technological interconnection - the preparatory period, the underground part, the above-ground part, external engineering networks, landscaping. The total duration of the construction of a residential building, depending on the duration of each redistribution and the degree of their overlapping, can be determined by one of the proposed four options. At the same time, a unified approach to determining the overall duration of construction on the basis of the provisions of a streamlined construction organization with the testing of results on the example of high-rise residential buildings of the typical I-155B series was developed, and the coefficients for combining the work and the main redevelopment of the building were determined.

  14. Systematically too low values of the cranking model collective inertia parameters

    International Nuclear Information System (INIS)

    Dudek, I.; Dudek, W.; Lukasiak-Ruchowska, E.; Skalski, I.

    1980-01-01

    Deformed Nilsson and Woods-Saxon potentials were employed for generating single particle states used henceforth for calculating the inertia tensor (cranking model and monopole pairing) and the collective energy surfaces (Strutinsky method). The deformation was parametrized in terms of quadrupole and hexadecapole degrees of freedom. The classical energy expression obtained from the inertia tensor and energy surfaces was quantized and the resulting stationary Schroedinger equation was solved using the approximate method. The second Isup(π) = 0 + 2 collective level energies were calculated for the Rare Earth and Actinide nuclei and the results compared with the experimental data. The vibrational level energies agree with the experimental ones much better for spherical nuclei for both single particle potentials; the discrepancies for deformed nuclei overestimate the experimental results by roughly a factor of two. It is argued that coupling of the axially symmetric quadrupole degrees of freedom to non-axial and hexadecapole ones does not affect the conclusions about systematically too low mass parameter values. The alternative explanation of the systematic deviations from the 0 + 2 level energies could be a systematically too high stiffness of the energy surfaces obrained with the Strutinsky method. (orig.)

  15. Determination of sustainable values for the parameters of the construction of residential buildings

    Directory of Open Access Journals (Sweden)

    Grigoreva Larisa

    2018-01-01

    Full Text Available For the formation of programs for housing construction and planning of capital investments, when developing the strategic planning companies by construction companies, the norms or calculated indicators of the duration of the construction of high-rise residential buildings and multifunctional complexes are mandatory. Determination of stable values of the parameters for the high-rise construction residential buildings provides an opportunity to establish a reasonable duration of construction at the planning and design stages of residential complexes, taking into account the influence of market conditions factors. The concept of the formation of enlarged models for the high-rise construction residential buildings is based on a real mapping in time and space of the most significant redistribution with their organizational and technological interconnection - the preparatory period, the underground part, the above-ground part, external engineering networks, landscaping. The total duration of the construction of a residential building, depending on the duration of each redistribution and the degree of their overlapping, can be determined by one of the proposed four options. At the same time, a unified approach to determining the overall duration of construction on the basis of the provisions of a streamlined construction organization with the testing of results on the example of high-rise residential buildings of the typical I-155B series was developed, and the coefficients for combining the work and the main redevelopment of the building were determined.

  16. Correlations between forced oscillation technique parameters and pulmonary densitovolumetry values in patients with acromegaly

    Directory of Open Access Journals (Sweden)

    G.B. Camilo

    2015-01-01

    Full Text Available The aims of this study were to evaluate the forced oscillation technique (FOT and pulmonary densitovolumetry in acromegalic patients and to examine the correlations between these findings. In this cross-sectional study, 29 non-smoking acromegalic patients and 17 paired controls were subjected to the FOT and quantification of lung volume using multidetector computed tomography (Q-MDCT. Compared with the controls, the acromegalic patients had a higher value for resonance frequency [15.3 (10.9-19.7 vs 11.4 (9.05-17.6 Hz, P=0.023] and a lower value for mean reactance [0.32 (0.21-0.64 vs 0.49 (0.34-0.96 cm H2O/L/s2, P=0.005]. In inspiratory Q-MDCT, the acromegalic patients had higher percentages of total lung volume (TLV for nonaerated and poorly aerated areas [0.42% (0.30-0.51% vs 0.25% (0.20-0.32%, P=0.039 and 3.25% (2.48-3.46% vs 1.70% (1.45-2.15%, P=0.001, respectively]. Furthermore, the acromegalic patients had higher values for total lung mass in both inspiratory and expiratory Q-MDCT [821 (635-923 vs 696 (599-769 g, P=0.021 and 844 (650-945 vs 637 (536-736 g, P=0.009, respectively]. In inspiratory Q-MDCT, TLV showed significant correlations with all FOT parameters. The TLV of hyperaerated areas showed significant correlations with intercept resistance (rs=−0.602, P<0.001 and mean resistance (rs=−0.580, P<0.001. These data showed that acromegalic patients have increased amounts of lung tissue as well as nonaerated and poorly aerated areas. Functionally, there was a loss of homogeneity of the respiratory system. Moreover, there were correlations between the structural and functional findings of the respiratory system, consistent with the pathophysiology of the disease.

  17. Task completion report for investigating why output signal-variable values differ from their output component-parameter values in test problem MST2

    International Nuclear Information System (INIS)

    Steinke, R.G.

    1997-01-01

    Signal-variable values and their component-parameter values differ in an end-of-timestep edit to the TRCOUT and TRCGRF files because signal variables have beginning-of-timestep values, and component parameters have end-of-timestep values. Oscillatory divergence in the MST2 standard test problem after 9000 s occurs because of TRAC-P's numerical evaluation at a 1000 material Courant number. The magnitude of that divergence has diminished by a factor of 3.5 from Version 5.3.01 to 5.4.15 and by a factor of 25 from Version 5.4.15 to 5.4.28. That divergence can be eliminated by evaluating MST2 with a maximum material Courant number of 500

  18. Expectation values of local fields for a two-parameter family of integrable models and related perturbed conformal field theories

    International Nuclear Information System (INIS)

    Baseilhac, P.; Fateev, V.A.

    1998-01-01

    We calculate the vacuum expectation values of local fields for the two-parameter family of integrable field theories introduced and studied by Fateev (1996). Using this result we propose an explicit expression for the vacuum expectation values of local operators in parafermionic sine-Gordon models and in integrable perturbed SU(2) coset conformal field theories. (orig.)

  19. A summary of the sources of input parameter values for the Waste Isolation Pilot Plant final porosity surface calculations

    International Nuclear Information System (INIS)

    Butcher, B.M.

    1997-08-01

    A summary of the input parameter values used in final predictions of closure and waste densification in the Waste Isolation Pilot Plant disposal room is presented, along with supporting references. These predictions are referred to as the final porosity surface data and will be used for WIPP performance calculations supporting the Compliance Certification Application to be submitted to the U.S. Environmental Protection Agency. The report includes tables and list all of the input parameter values, references citing their source, and in some cases references to more complete descriptions of considerations leading to the selection of values

  20. A summary of the sources of input parameter values for the Waste Isolation Pilot Plant final porosity surface calculations

    Energy Technology Data Exchange (ETDEWEB)

    Butcher, B.M.

    1997-08-01

    A summary of the input parameter values used in final predictions of closure and waste densification in the Waste Isolation Pilot Plant disposal room is presented, along with supporting references. These predictions are referred to as the final porosity surface data and will be used for WIPP performance calculations supporting the Compliance Certification Application to be submitted to the U.S. Environmental Protection Agency. The report includes tables and list all of the input parameter values, references citing their source, and in some cases references to more complete descriptions of considerations leading to the selection of values.

  1. Antecedents and outcomes of meaningful work among school teachers

    Directory of Open Access Journals (Sweden)

    Elmari Fouché

    2017-03-01

    Research purpose: The aim of this study was to investigate antecedents and outcomes of meaningful work among school teachers. Motivation for the study: Meaningful work underpins people’s motivation and affects their well-being and job satisfaction. Furthermore, it is a significant pathway to healthy and authentic organisations. However, a research gap exists regarding the effects of different antecedents and outcomes of meaningful work. Research approach, design and method: A cross-sectional survey was used with a convenience sample of 513 teachers. The Work-Life Questionnaire, Revised Job Diagnostic Survey, Co-worker Relations Scale, Work and Meaning Inventory, Personal Resources Scale, Work Engagement Scale, Turnover Intention Scale and a measure of self-rated performance were administered. Main findings: A calling orientation, job design and co-worker relations were associated with meaningful work. A low calling orientation and poor co-worker relationships predicted burnout. A calling orientation, a well-designed job, good co-worker relationships and meaningful work predicted work engagement. Job design was moderately associated with self-ratings of performance. The absence of a calling orientation predicted teachers’ intention to leave the organisation. Practical/managerial implications: Educational managers should consider implementing interventions to affect teachers’ calling orientation (through job crafting, perceptions of the nature of their jobs (by allowing autonomy and co-worker relations (through teambuilding to promote perceptions of meaningful work. Promoting perceptions of meaningful work might contribute to lower burnout, higher work engagement, better self-ratings of performance and retention of teachers. Contribution/value-add: This study contributes to scientific knowledge regarding the effects of three antecedents, namely a calling orientation, job design and co-worker relationships on meaningful work. It also contributed to knowledge

  2. Sensitivity of reactor integral parameters to #betta##betta# parameter of resolved resonances of fertile isotopes and to the α values, in thermal and epithermal spectra

    International Nuclear Information System (INIS)

    Barroso, D.E.G.

    1982-01-01

    A sensitivity analysis of reactor integral parameter to more 10% variation in the resolved resonance parameters #betta##betta# of the fertile isotope and the variations of more 10% in the α values (#betta# sub(#betta#)/#betta# sub(f)) of fissile isotopes of PWR fuel elements, is done. The analysis is made with thermal and epithermal spectra, those last generated in a fuel cell with low V sub(M)/V sub(F). The HAMMER system, the interface programs HELP and LITHE and the HAMMER computer codes, were used as a base for this study. (E.G.) [pt

  3. Improved performance of photosynthetic light response equations with unified parameters for rice leaves with different SPAD values

    International Nuclear Information System (INIS)

    Xu, J.; Peng, S.; Kong, W.

    2015-01-01

    The rectangular hyperbola (RH), Mitscherlich (M) and YE equation were applied to describe the photosynthetic light response (PLR) curves measured from rice leaves with different SPAD values, to reveal the relationship between SPAD values and parameters in different equations, and to establish the modified PLR equations. The parameters in PLR equations are largely varied. SPAD value, as an indicator of leaf N contents, was highly correlated to the parameter of Pnmax in RH, M and YE equations. Incorporating the factor SPAD into PLR equations, the modified equations (MRH, MM, and MYE) were established which were feasible to describing the PLR curves for leaves with different SPAD values using the identical parameters for the ten PLR curves as a whole, and perform much better than the general PLR equations (GRH, GM, and GYE). It indicated that incorporating easy available indicators of leaf physiological and morphological traits in the PLR equations, such as SPAD as an indicator of leaf N or Chlorophyll contents, is an easy way to overcome the shortcoming of parameters variation in PLR equations between individuals of the same specie growing in different environments. Further validation should be done for different crops with both SPAD and other possible factors. (author)

  4. Building Bridges Through Meaningful Occupation

    Directory of Open Access Journals (Sweden)

    Jennifer Fortuna

    2017-07-01

    Full Text Available Mary Block, MS, OTR/L, an occupational therapist and artist based in Illinois, provided the cover art for the Summer 2017 issue of The Open Journal of Occupational Therapy (OJOT. Generations is a sculpture made from concrete that measures 240 x100 in. (6.096 x 2.54 m. The piece was commissioned by Mary’s home town, the Village of Deerfield, IL. Mary always knew she wanted to be an artist. When competing paradigms altered Mary’s career path, the field of occupational therapy helped her to shape a new worldview. In uncertain times, meaningful occupation empowered Mary to start over again where she originally began

  5. Value of diffusion-weighted MR imaging using various parameters for assessment and characterization of solitary pulmonary nodules

    International Nuclear Information System (INIS)

    Koyama, Hisanobu; Ohno, Yoshiharu; Seki, Shinichiro; Nishio, Mizuho; Yoshikawa, Takeshi; Matsumoto, Sumiaki; Maniwa, Yoshimasa; Itoh, Tomoo; Nishimura, Yoshihiro; Sugimura, Kazuro

    2015-01-01

    Highlights: •Signal–intensity ratio evaluation between lesion and spinal cord is practical method. •Apparent diffusion coefficients may not contribute to the diagnosis of malignant. •True diffusion coefficients may have low potential for the differentiation. •Perfusion fractions may be less specific parameter of diagnosis of pulmonary nodule. •Choice of b values shows little impact for differentiation of pulmonary nodules. -- Abstract: Objectives: To determine the appropriate parameters and evaluation method for characterizing solitary pulmonary nodules (SPNs) using quantitative parameters of diffusion-weighted imaging (DWI). Methods: Thirty-two subjects with 36 SPNs underwent DWI with seven different b values (0, 50, 100, 150, 300, 500, and 1000 s/mm 2 ). Five quantitative parameters were obtained from the region of interest drawn over each SPN: apparent diffusion coefficients (ADCs), true diffusion coefficients (DCs), and perfusion fractions (PFs), and signal–intensity ratios between lesion and spinal cord from DWI (b values: 1000 [LSR 1000 ] and 500 [LSR 500 )]). All quantitative parameters and the diagnostic capabilities were statistically compared. Results: SPNs were diagnosed as follow: malignant (n = 27) and benign (n = 9). Parameter comparisons for malignant and benign showed both LSRs differed significantly (p < 0.05). Applying feasible threshold values showed LSR 500 specificity (88.9% [8/9]) and accuracy (77.8% [28/36]) were significantly higher than ADC, DC, and PF specificity and accuracy (p < 0.05). LSR 1000 accuracy (72.2% [26/36]) was significantly higher than DC accuracy, and its specificity (88.9% [8/9]) was significantly higher than ADC, DC, and PF specificities (p < 0.05). Conclusions: For quantitative differentiation of SPNs, LSR evaluation was more useful and practical than ADC, DC, and PF, and choice of b values showed little impact for the differentiation

  6. Wavelet theory and belt finishing process, influence of wavelet shape on the surface roughness parameter values

    International Nuclear Information System (INIS)

    Khawaja, Z; Mazeran, P-E; Bigerelle, M; Guillemot, G; Mansori, M El

    2011-01-01

    This article presents a multi-scale theory based on wavelet decomposition to characterize the evolution of roughness in relation with a finishing process or an observed surface property. To verify this approach in production conditions, analyses were developed for the finishing process of the hardened steel by abrasive belts. These conditions are described by seven parameters considered in the Tagushi experimental design. The main objective of this work is to identify the most relevant roughness parameter and characteristic length allowing to assess the influence of finishing process, and to test the relevance of the measurement scale. Results show that wavelet approach allows finding this scale.

  7. Extreme value analysis of meteorological parameters observed during the period 1994-2001 at Kakrapar Atomic Power Station

    International Nuclear Information System (INIS)

    Ramkumar, S.; Dole, M.L.; Nankar, D.P.; Rajan, M.P.; Gurg, R.P.

    2003-01-01

    In the design of engineering structures, an understanding of extreme weather conditions that may occur at the site of interest is very essential, so that the structures can be designed to withstand such situations. In this report an analysis of extreme values of meteorological parameters observed at Kakrapar Atomic Power Station site for the period 1994 -2001 is described. The parameters considered are maximum and minimum air temperature, maximum wind speed and gust, and maximum rainfall in a month, in a day, in an hour and annual rainfall. The extreme value analysis reveals that annual rainfall, maximum monthly rainfall, minimum air temperature and maximum wind speed at 10 m obey Fisher-Tippet Type -1 distribution whereas maximum daily rainfall, maximum hourly rainfall, maxinlum air temperature and maximum wind speed at 30 m obey Fisher-Tippet Type -2 distribution function. There is no difference in correlation coefficients and fit both extreme value distribution function. Co-efficients of the distribution functions for each variable are established. Extreme values of parameters corresponding to return periods of 50 and 100 years are derived. These derived extreme values are particularly useful for arriving at suitable design basis values to ensure the safety of any civil structure in and around Kakrapar Atomic Power Station site with respect to stresses due to weather conditions. (author)

  8. The effect of occupational meaningfulness on occupational commitment

    Directory of Open Access Journals (Sweden)

    Itai Ivtzan

    2014-11-01

    Full Text Available Existing research lacks a scholarly consensus on how to define and validly measure ‘meaningful work’ (e.g., Rosso, Dekas & Wrzesniewski, 2010. The following correlational study highlights the value of investigating meaningfulness in the context of occupational commitment. The study hypothesizes that occupational commitment is positively correlated with occupational meaningfulness, where meaningfulness is defined as the extent to which people’s occupations contribute to personal meaning in life. One-hundred and fifty-six full-time office based UK workers completed an online questionnaire including 18 questions measuring levels of occupational commitment (Meyer, Allen & Smith, 1993, in addition to six novel items measuring occupational meaningfulness. The results supported the hypothesis and also showed that the affective sub-type of occupational commitment had the highest correlation with occupational meaningfulness. Such results exhibit the importance of finding meaning at work, as well as the relevance of this to one’s level of commitment to his or her job. This paper argues that individuals should consider OM before choosing to take a specific role, whereas organizations ought to consider the OM of their potential candidates before recruiting them into a role. Possible directions for future research directions are also discussed.

  9. Effects of correcting missing daily feed intake values on the genetic parameters and estimated breeding values for feeding traits in pigs.

    Science.gov (United States)

    Ito, Tetsuya; Fukawa, Kazuo; Kamikawa, Mai; Nikaidou, Satoshi; Taniguchi, Masaaki; Arakawa, Aisaku; Tanaka, Genki; Mikawa, Satoshi; Furukawa, Tsutomu; Hirose, Kensuke

    2018-01-01

    Daily feed intake (DFI) is an important consideration for improving feed efficiency, but measurements using electronic feeder systems contain many missing and incorrect values. Therefore, we evaluated three methods for correcting missing DFI data (quadratic, orthogonal polynomial, and locally weighted (Loess) regression equations) and assessed the effects of these missing values on the genetic parameters and the estimated breeding values (EBV) for feeding traits. DFI records were obtained from 1622 Duroc pigs, comprising 902 individuals without missing DFI and 720 individuals with missing DFI. The Loess equation was the most suitable method for correcting the missing DFI values in 5-50% randomly deleted datasets among the three equations. Both variance components and heritability for the average DFI (ADFI) did not change because of the missing DFI proportion and Loess correction. In terms of rank correlation and information criteria, Loess correction improved the accuracy of EBV for ADFI compared to randomly deleted cases. These findings indicate that the Loess equation is useful for correcting missing DFI values for individual pigs and that the correction of missing DFI values could be effective for the estimation of breeding values and genetic improvement using EBV for feeding traits. © 2017 The Authors. Animal Science Journal published by John Wiley & Sons Australia, Ltd on behalf of Japanese Society of Animal Science.

  10. The prognostic value of cortical magnetic stimulation in acute middle cerebral artery infarction compared to other parameters

    NARCIS (Netherlands)

    Timmerhuis, Th.P.J.; Hageman, G.; Oosterloo, Sebe J.; Rozeboom, A.R.

    1996-01-01

    The prognostic value of magnetic evoked potentials (MEP), somatosensory evoked potentials (SSEP), age and radiological parameters was determined in 50 patients with acute middle cerebral artery infarction. We performed MEP and SSEP within 4 days and after 6 weeks and 3 months of the infarction and

  11. Equations for estimating synthetic unit-hydrograph parameter values for small watersheds in Lake County, Illinois

    Science.gov (United States)

    Melching, C.S.; Marquardt, J.S.

    1997-01-01

    Design hydrographs computed from design storms, simple models of abstractions (interception, depression storage, and infiltration), and synthetic unit hydrographs provide vital information for stormwater, flood-plain, and water-resources management throughout the United States. Rainfall and runoff data for small watersheds in Lake County collected between 1990 and 1995 were studied to develop equations for estimation of synthetic unit-hydrograph parameters on the basis of watershed and storm characteristics. The synthetic unit-hydrograph parameters of interest were the time of concentration (TC) and watershed-storage coefficient (R) for the Clark unit-hydrograph method, the unit-graph lag (UL) for the Soil Conservation Service (now known as the Natural Resources Conservation Service) dimensionless unit hydrograph, and the hydrograph-time lag (TL) for the linear-reservoir method for unit-hydrograph estimation. Data from 66 storms with effective-precipitation depths greater than 0.4 inches on 9 small watersheds (areas between 0.06 and 37 square miles (mi2)) were utilized to develop the estimation equations, and data from 11 storms on 8 of these watersheds were utilized to verify (test) the estimation equations. The synthetic unit-hydrograph parameters were determined by calibration using the U.S. Army Corps of Engineers Flood Hydrograph Package HEC-1 (TC, R, and UL) or by manual analysis of the rainfall and run-off data (TL). The relation between synthetic unit-hydrograph parameters, and watershed and storm characteristics was determined by multiple linear regression of the logarithms of the parameters and characteristics. Separate sets of equations were developed with watershed area and main channel length as the starting parameters. Percentage of impervious cover, main channel slope, and depth of effective precipitation also were identified as important characteristics for estimation of synthetic unit-hydrograph parameters. The estimation equations utilizing area

  12. New Values of Cross-Talk Parameters for Twisted Pair Model

    OpenAIRE

    Milos Kozak; Lukas Cepa; Jiri Vodrazka

    2010-01-01

    Near-end Crosstalk (NEXT) and Far-end Crosstalk (FEXT) of unshielded twisted pair (UTP) cable are the main factors limiting the information capacity in data transmission. Crosstalk depends mostly on the frequency. Frequency dependent transfer functions and crosstalk attenuation may be obtained by measurement, but for the analytical description of the transmission channel's parameters is useful to define functions modelling the crosstalk. The paper describes the measuri...

  13. Nuclide documentation. Element specific parameter values used in the biospheric models of the safety assessments SR 97 and SAFE

    International Nuclear Information System (INIS)

    Karlsson, Sara; Bergstroem, Ulla

    2002-05-01

    In this report the element and nuclide specific parameter values used in the biospheric models of the safety assessments SR 97 and SAFE are presented. The references used are presented and where necessary the process of estimation of data is described. The parameters treated in this report are distribution coefficients in soil, organic soil and suspended matter in freshwater and brackish water, root uptake factors for pasturage, cereals, root crops and vegetables, bioaccumulation factors for freshwater fish, brackish water fish, freshwater invertebrates and marine water plants, transfer coefficients for transfer to milk and meat, translocation factors and dose coefficients for external exposure, ingestion (age-dependent values) and inhalation (age-dependent values). The radionuclides treated are those which could be of interest in the two safety assessments. Physical data such as half-lives and type of decay are also presented

  14. Nuclide documentation. Element specific parameter values used in the biospheric models of the safety assessments SR 97 and SAFE

    Energy Technology Data Exchange (ETDEWEB)

    Karlsson, Sara; Bergstroem, Ulla [Studsvik Eco and Safety AB, Nykoeping (Sweden)

    2002-05-01

    In this report the element and nuclide specific parameter values used in the biospheric models of the safety assessments SR 97 and SAFE are presented. The references used are presented and where necessary the process of estimation of data is described. The parameters treated in this report are distribution coefficients in soil, organic soil and suspended matter in freshwater and brackish water, root uptake factors for pasturage, cereals, root crops and vegetables, bioaccumulation factors for freshwater fish, brackish water fish, freshwater invertebrates and marine water plants, transfer coefficients for transfer to milk and meat, translocation factors and dose coefficients for external exposure, ingestion (age-dependent values) and inhalation (age-dependent values). The radionuclides treated are those which could be of interest in the two safety assessments. Physical data such as half-lives and type of decay are also presented.

  15. Analysis of radiological parameters associated with decreased fractional anisotropy values on diffusion tensor imaging in patients with lumbar spinal stenosis.

    Science.gov (United States)

    Wang, Xiandi; Wang, Hongli; Sun, Chi; Zhou, Shuyi; Meng, Tao; Lv, Feizhou; Ma, Xiaosheng; Xia, Xinlei; Jiang, Jianyuan

    2018-04-26

    Previous studies have indicated that decreased fractional anisotropy (FA) values on diffusion tensor imaging (DTI) are well correlated with the symptoms of nerve root compression. The aim of our study is to determine primary radiological parameters associated with decreased FA values in patients with lumbar spinal stenosis involving single L5 nerve root. Patients confirmed with single L5 nerve root compression by transforaminal nerve root blocks were included in this study. FA values of L5 nerve roots on both symptomatic and asymptomatic side were obtained. Conventional radiological parameters, such as disc height, degenerative scoliosis, dural sac cross-sectional area (DSCSA), foraminal height (FH), hypertrophic facet joint degeneration (HFJD), sagittal rotation (SR), sedimentation sign, sagittal translation and traction spur were measured. Correlation and regression analyses were performed between the radiological parameters and FA values of the symptomatic L5 nerve roots. A predictive regression equation was established. Twenty-one patients were included in this study. FA values were significantly lower at the symptomatic side comparing to the asymptomatic side (0.263 ± 0.069 vs. 0.334 ± 0.080, P = 0.038). DSCSA, FH, HFJD, and SR were significantly correlated with the decreased FA values, with r = 0.518, 0.443, 0.472 and - 0.910, respectively (P values, and the regression equation is FA = - 0.012 × SR + 0.002 × DSCSA. DSCSA and SR were primary contributors to decreased FA values in LSS patients involving single L5 nerve root, indicating that central canal decompression and segmental stability should be the first considerations in preoperative planning of these patients. These slides can be retrieved under Electronic Supplementary Material.

  16. Cultural value orientation and authoritarian parenting as parameters of bullying and victimization at school.

    Science.gov (United States)

    Georgiou, Stelios N; Fousiani, Kyriaki; Michaelides, Michalis; Stavrinides, Panayiotis

    2013-01-01

    The purpose of the present study was to examine the existing association between cultural value orientation, authoritarian parenting, and bullying and victimization at school. The participants (N = 231) were early adolescents, randomly selected from 11 different schools in urban and rural areas of Cyprus. Participants completed self reports measuring cultural value orientation, authoritarian parenting, bullying, and victimization. These instruments were the following: the cultural value scale (CVS), the parental authority questionnaire (PAQ), and the revised bullying and victimization questionnaire (BVQ-R). Structural equation modeling (SEM) was used to examine mediation effects. It was found that vertical individualism acted as a mediator between authoritarian parenting and bullying. Statistically significant positive correlations were found between authoritarian parenting and the vertical dimensions of both cultural value orientations (individualism and collectivism), but not with the horizontal dimensions of either cultural orientation. Further, authoritarian parenting was also positively associated with bullying and victimization at school. The main contribution of the present study is the finding that vertical individualism significantly mediates the relationship between authoritarian parental style and bullying propensity.

  17. Value of a new inflammatory parameter in malignant pleural mesothelioma prognosis

    Directory of Open Access Journals (Sweden)

    Özlem Abakay

    2013-01-01

    Full Text Available Malignant Pleural Mesothelioma (MPM generallyassociated with asbestos exposure is a tumor withpoor prognosis. Modified Glasgow Prognostic Score(GPS which may be a prognostic parameter in patientswith MPM is a designed based score including increasedC-reactive protein (CRP levels and decreased albumin.In this study we aimed to investigate the effect of GPSscore on the prognosis of MPM and the role of other potentialfactors.Methods: In this retrospective planned study 140 histologicaldiagnosed MPM patients were included.Results: Mean age of 140 MPM patients were 52.92years (83 male and 57 female. A total of 91 patients hadenvironmental asbestos exposure and exposure timewas the 31 years. Symptoms of the patients started approximately4.8 months before the application. The mostfrequently seen symptoms were in 125 patients dyspnea,in 94 patients chest pain and in 22 patients weight loss.GPS score of the patients were as follows; 64 patientstwo, 14 patients one, 22 patients zero. Of the patients,112 died and 28 were alive. Mean survival time was 14months. Patients with GPS score 2 lived for 10 months,GPS score 1 lived for 15 and GPS score 0 lived for 18months. This difference was statistically significant. Furthermore,the male sex and age older than 65 years werefound as poor prognostic parameters on the survival.Conclusion: A simple and inexpensive parameter able tobe used to estimate the prognosis of MPM patients couldnot be developed .GPS score increases in inflammatoryconditions. GPS is a simple and inexpensive parameterthat can be used for detecting the severity of patients withMPM.Key words: Modified Glasgow Prognostic Score, MalignantPleural Mesothelioma, Prognosis

  18. RESEARCHES REGARDING THE MICROBIOLOGIC PARAMETERS VALUE FROM RAW MILK USED IN TELEMEA CHEESE TECHNOLOGICAL PROCESS

    Directory of Open Access Journals (Sweden)

    ANDRA SULER

    2008-10-01

    Full Text Available An important faze for food quality control is verification of microbiological parameters of food products. In this way is assuring the prevention of alimentation toxicological infections to consumer, avoiding the technological and economical losses as well as increasing the products conservation period. In this paper are presents the microbiological exam results from raw milk used in Telemea cheese technological process, for 5 stations studied. The determinations were made on 2 series with 57 samples each of them, prelevated in reception fase, in summer and winter season.

  19. Valuing Ecosystem Services with Fishery Rents: A Lumped-Parameter Approach to Hypoxia in the Neuse River Estuary

    Directory of Open Access Journals (Sweden)

    Larry B. Crowder

    2011-11-01

    Full Text Available Valuing ecosystem services with microeconomic underpinnings presents challenges because these services typically constitute nonmarket values and contribute to human welfare indirectly through a series of ecological pathways that are dynamic, nonlinear, and difficult to quantify and link to appropriate economic spatial and temporal scales. This paper develops and demonstrates a method to value a portion of ecosystem services when a commercial fishery is dependent on the quality of estuarine habitat. Using a lumped-parameter, dynamic open access bioeconomic model that is spatially explicit and includes predator-prey interactions, this paper quantifies part of the value of improved ecosystem function in the Neuse River Estuary when nutrient pollution is reduced. Specifically, it traces the effects of nitrogen loading on the North Carolina commercial blue crab fishery by modeling the response of primary production and the subsequent impact on hypoxia (low dissolved oxygen. Hypoxia, in turn, affects blue crabs and their preferred prey. The discounted present value fishery rent increase from a 30% reduction in nitrogen loadings in the Neuse is $2.56 million, though this welfare estimate is fairly sensitive to some parameter values. Surprisingly, this number is not sensitive to initial conditions.

  20. Choosing put option parameters based on quantiles from the distribution of portfolio value

    OpenAIRE

    Bell, Peter Newton

    2014-01-01

    This paper explores how a put option changes the probability distribution of portfolio value. The paper extends the model introduced in Bell (2014) by allowing both the quantity and strike price to vary. I use the 5% quantile from the portfolio distribution to measure riskiness and compare different put options. I report a so-called ‘quantile surface’ that shows the quantile across different combinations of quantity and strike price. I find that it is possible to maximize the quantile by ...

  1. Sensitivity of precipitation to parameter values in the community atmosphere model version 5

    Energy Technology Data Exchange (ETDEWEB)

    Johannesson, Gardar; Lucas, Donald; Qian, Yun; Swiler, Laura Painton; Wildey, Timothy Michael

    2014-03-01

    One objective of the Climate Science for a Sustainable Energy Future (CSSEF) program is to develop the capability to thoroughly test and understand the uncertainties in the overall climate model and its components as they are being developed. The focus on uncertainties involves sensitivity analysis: the capability to determine which input parameters have a major influence on the output responses of interest. This report presents some initial sensitivity analysis results performed by Lawrence Livermore National Laboratory (LNNL), Sandia National Laboratories (SNL), and Pacific Northwest National Laboratory (PNNL). In the 2011-2012 timeframe, these laboratories worked in collaboration to perform sensitivity analyses of a set of CAM5, 2° runs, where the response metrics of interest were precipitation metrics. The three labs performed their sensitivity analysis (SA) studies separately and then compared results. Overall, the results were quite consistent with each other although the methods used were different. This exercise provided a robustness check of the global sensitivity analysis metrics and identified some strongly influential parameters.

  2. Effects of Initial Values and Convergence Criterion in the Two-Parameter Logistic Model When Estimating the Latent Distribution in BILOG-MG 3.

    Directory of Open Access Journals (Sweden)

    Ingo W Nader

    Full Text Available Parameters of the two-parameter logistic model are generally estimated via the expectation-maximization algorithm, which improves initial values for all parameters iteratively until convergence is reached. Effects of initial values are rarely discussed in item response theory (IRT, but initial values were recently found to affect item parameters when estimating the latent distribution with full non-parametric maximum likelihood. However, this method is rarely used in practice. Hence, the present study investigated effects of initial values on item parameter bias and on recovery of item characteristic curves in BILOG-MG 3, a widely used IRT software package. Results showed notable effects of initial values on item parameters. For tighter convergence criteria, effects of initial values decreased, but item parameter bias increased, and the recovery of the latent distribution worsened. For practical application, it is advised to use the BILOG default convergence criterion with appropriate initial values when estimating the latent distribution from data.

  3. The value of iodide as a parameter in the chemical characterisation of groundwaters

    Science.gov (United States)

    Lloyd, J. W.; Howard, K. W. F.; Pacey, N. R.; Tellam, J. H.

    1982-06-01

    Brackish and saline groundwaters can severely constrain the use of fresh groundwaters. Their chemical characterisation is important in understanding the hydraulic conditions controlling their presence in an aquifer. Major ions are frequently of limited value but minor ions can be used. Iodide in groundwater is particularly significant in many environments due to the presence of soluble iodine in aquifer matrix materials. Iodide is found in groundwaters in parts of the English Chalk aquifer in concentrations higher than are present in modern seawater. Its presence is considered as a indication of groundwater residence and is of use in the characterisation of fresh as well as saline waters. Under certain circumstances modern seawater intrusion into aquifers along English estuaries produces groundwaters which are easily identified due to iodide enrichment from estuarine muds. In other environments iodide concentrations are of value in distinguishing between groundwaters in limestones and shaly gypsiferous rocks as shown by a study in Qatar, while in an alluvial aquifer study in Peru iodide has been used to identify groundwaters entering the aquifer from adjacent granodiorites.

  4. Winter blood values of selected parameters in a group of non-hibernating captive brown bears (Ursus arctos).

    Science.gov (United States)

    Sergiel, A; Bednarski, M; Maślak, R; Piasecki, T; Huber, D

    2015-01-01

    Bears undergo some significant changes reflected in blood values during winter season. The most significant are reduced urea and increased creatinine, by some authors considered to be physiological indicators of hibernation. Studied group of six captive brown bears (Ursus arctos) showed decreased activity in winter but were accepting food and walked outdoors. Blood parameters assessed in February 2011 revealed mean values of leucocytes and neutrophils as significantly lower, and creatinine significantly increased compared to captive and free living bears sampled during other seasons when bears are active.

  5. Boundedness and global robust stability analysis of delayed complex-valued neural networks with interval parameter uncertainties.

    Science.gov (United States)

    Song, Qiankun; Yu, Qinqin; Zhao, Zhenjiang; Liu, Yurong; Alsaadi, Fuad E

    2018-07-01

    In this paper, the boundedness and robust stability for a class of delayed complex-valued neural networks with interval parameter uncertainties are investigated. By using Homomorphic mapping theorem, Lyapunov method and inequality techniques, sufficient condition to guarantee the boundedness of networks and the existence, uniqueness and global robust stability of equilibrium point is derived for the considered uncertain neural networks. The obtained robust stability criterion is expressed in complex-valued LMI, which can be calculated numerically using YALMIP with solver of SDPT3 in MATLAB. An example with simulations is supplied to show the applicability and advantages of the acquired result. Copyright © 2018 Elsevier Ltd. All rights reserved.

  6. The Use of Asymptotic Functions for Determining Empirical Values of CN Parameter in Selected Catchments of Variable Land Cover

    Directory of Open Access Journals (Sweden)

    Wałęga Andrzej

    2017-12-01

    Full Text Available The aim of the study was to assess the applicability of asymptotic functions for determining the value of CN parameter as a function of precipitation depth in mountain and upland catchments. The analyses were carried out in two catchments: the Rudawa, left tributary of the Vistula, and the Kamienica, right tributary of the Dunajec. The input material included data on precipitation and flows for a multi-year period 1980–2012, obtained from IMGW PIB in Warsaw. Two models were used to determine empirical values of CNobs parameter as a function of precipitation depth: standard Hawkins model and 2-CN model allowing for a heterogeneous nature of a catchment area.

  7. Predictive value of semen parameters and age of the couple in pregnancy outcome after Intrauterine insemination

    Directory of Open Access Journals (Sweden)

    Marjan Sabbaghian

    2013-11-01

    Full Text Available Background: Intrauterine insemination (IUI is one the most common methods in infertility treatment, but its efficiency in infertile couples with male factor is controversial. This study is a retrospective study about correlation between semen parameters and male and female age with successful rate of IUI in patients attending to Royan Institute.Methods: A total of 998 consecutive couples in a period of 6 months undergoing IUI were included. They were classified into two groups: couples with successful and unsuccessful pregnancy. Main outcome was clinical pregnancy. Data about male and female ages and semen analysis including concentration, total sperm motility, class A motility, class B motility, class A+B motility and normal morphology was extracted from patients’ records. Semen samples were collected by masturbation or coitus after 2 to 7 days of abstinence. Their female partners were reported to have no chronic medi-cal conditions and have normal menstrual cycles.Results: One hundred and fifty seven of total 998 cycles (15.7% achieved pregnancy. The average of female age in successful and unsuccessful group was 28.95±4.19 and 30.00±4.56 years, respectively. Mean of male age was 33.97±4.85 years in successful group and 34.44±4.62 years in unsuccessful group. In successful and unsuccessful groups, average of sperm concentration was 53.62±38.45 and 46.26±26.59 (million sperm/ml, normal morphology of sperm was 8.98±4.31 (% and 8.68±4.81 (%, sperm total motility was 47.24±18.92 (% and 43.70±20.22 (% and total motile sperm count was 80.10±63.61 million and 78.57±68.22 million, respectively.Conclusion: There was no significant difference in mean of females’ age and males’ age between successful and unsuccessful groups (P<0.05. In addition, there was no significant difference in semen parameters including concentration, total sperm motility, class A motility, class B motility, class A+B motility and normal morphology between two

  8. Effects of doping parameters on the CIE value of flexible white organic light emitting diodes

    Energy Technology Data Exchange (ETDEWEB)

    Juang Fuhshyang; Lin Mingyein; Yang Chanyi [Institute of Electro-Optical and Materials Science, National Huwei University of Science and Technology, Huwei, Yunlin (Taiwan); Tsai Yusheng [Department of Electro-Optics Engineering, National Huwei University of Science and Technology, Huwei, Yunlin (Taiwan); Lin, David [Windell Corporation, 1F, No. 9, Kung-Yen 7 Road, Industrial Zone, Taichung (Taiwan); Wang Wentunn; Shen Chaiyuan [Electronics Research and Service Organization, Industrial Technology Research Institute, 195 Chung Hsing Rd., Sec. 4 Chu Tung, Hsin Chu (Taiwan)

    2004-09-01

    Red dopants were doped in different emitters, blue and green, respectively, to fabricate white organic light emitting diodes on flexible substrates. The competitive emission between blue and red emitters with various doped-zones was studied. When the DCJT doped zone was located far away from the hole-injection layer, both the blue and red color can be emitted. An appropriate red-dopant position in the device enhanced the green emission from 8-hydroxyquinoline aluminum (Alq3) which was combined with the red and blue emission to generate a white light. Finally, a white emission with the CIE value, (0.30, 0.32), independent of the applied voltage, was obtained with the optimum doped width and location. (copyright 2004 WILEY-VCH Verlag GmbH and Co. KGaA, Weinheim) (orig.)

  9. Existence of solutions to fractional boundary-value problems with a parameter

    Directory of Open Access Journals (Sweden)

    Ya-Ning Li

    2013-06-01

    Full Text Available This article concerns the existence of solutions to the fractional boundary-value problem $$displaylines{ -frac{d}{dt} ig(frac{1}{2} {}_0D_t^{-eta}+ frac{1}{2}{}_tD_{T}^{-eta}igu'(t=lambda u(t+abla F(t,u(t,quad hbox{a.e. } tin[0,T], cr u(0=0,quad u(T=0. }$$ First for the eigenvalue problem associated with it, we prove that there is a sequence of positive and increasing real eigenvalues; a characterization of the first eigenvalue is also given. Then under different assumptions on the nonlinearity F(t,u, we show the existence of weak solutions of the problem when $lambda$ lies in various intervals. Our main tools are variational methods and critical point theorems.

  10. Early Site Permit Demonstration Program, plant parameters envelopes: Comparison with ranges of values for four hypothetical sites

    International Nuclear Information System (INIS)

    1992-09-01

    The purpose of this volume is to report the results of the comparison of the ALWR plan parameters envelope with values of site characteristics developed for our hypothetical sites that generally represent conditions encountered within the United States. This effort is not intended to identify or address the suitability of any existing site, site area, or region in the United States. Also included in this volume is Appendix F, SERCH Summaries Regarding Siting

  11. Weighted Moments Estimators of the Parameters for the Extreme Value Distribution Based on the Multiply Type II Censored Sample

    Directory of Open Access Journals (Sweden)

    Jong-Wuu Wu

    2013-01-01

    Full Text Available We propose the weighted moments estimators (WMEs of the location and scale parameters for the extreme value distribution based on the multiply type II censored sample. Simulated mean squared errors (MSEs of best linear unbiased estimator (BLUE and exact MSEs of WMEs are compared to study the behavior of different estimation methods. The results show the best estimator among the WMEs and BLUE under different combinations of censoring schemes.

  12. Existence of positive solutions for nonlocal second-order boundary value problem with variable parameter in Banach spaces

    Directory of Open Access Journals (Sweden)

    Zhang Peiguo

    2011-01-01

    Full Text Available Abstract By obtaining intervals of the parameter λ, this article investigates the existence of a positive solution for a class of nonlinear boundary value problems of second-order differential equations with integral boundary conditions in abstract spaces. The arguments are based upon a specially constructed cone and the fixed point theory in cone for a strict set contraction operator. MSC: 34B15; 34B16.

  13. Prospective Cohort Study Evaluating the Prognostic Value of Simple EEG Parameters in Postanoxic Coma.

    Science.gov (United States)

    Azabou, Eric; Fischer, Catherine; Mauguiere, François; Vaugier, Isabelle; Annane, Djillali; Sharshar, Tarek; Lofaso, Fréderic

    2016-01-01

    We prospectively studied early bedside standard EEG characteristics in 61 acute postanoxic coma patients. Five simple EEG features, namely, isoelectric, discontinuous, nonreactive to intense auditory and nociceptive stimuli, dominant delta frequency, and occurrence of paroxysms were classified yes or no. Sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), and area under the receiver operating characteristic curve (AUC) of each of these variables for predicting an unfavorable outcome, defined as death, persistent vegetative state, minimally conscious state, or severe neurological disability, as assessed 1 year after coma onset were computed as well as Synek's score. The outcome was unfavorable in 56 (91.8%) patients. Sensitivity, specificity, PPV, NPV, and AUC of nonreactive EEG for predicting an unfavorable outcome were 84%, 80%, 98%, 31%, and 0.82, respectively; and were all very close to the ones of Synek score>3, which were 82%, 80%, 98%, 29%, and 0.81, respectively. Specificities for predicting an unfavorable outcome were 100% for isoelectric, discontinuous, or dominant delta activity EEG. These 3 last features were constantly associated to unfavorable outcome. Absent EEG reactivity strongly predicted an unfavorable outcome in postanoxic coma, and performed as accurate as a Synek score>3. Analyzing characteristics of some simple EEG features may easily help nonneurophysiologist physicians to investigate prognostic issue of postanoxic coma patient. In this study (a) discontinuous, isoelectric, or delta-dominant EEG were constantly associated with unfavorable outcome and (b) nonreactive EEG performed prognostic as accurate as a Synek score>3. © EEG and Clinical Neuroscience Society (ECNS) 2015.

  14. Influence of selected test parameters on measured values during the MSCR test

    Science.gov (United States)

    Benešová, Lucie; Valentin, Jan

    2017-09-01

    One of today’s most commonly used test on a Dynamic Shear Rheometer (DSR) is the Multiple Stress Creep Recovery (MSCR) test. The test is described in the standard EN 16659, which is valid in the Czech Republic since October 2016. The principle of the test is based on repeated loading and recovering of a bitumen sample, according to which it is possible to determine the percentage of elastic recovery (R) and non-recoverable creep compliance (Jnr) of the bituminous binder. This method has been recently promoted as the most suitable test for assessing the resistance of bituminous binders to permanent deformation. The test is performed at higher temperatures and is particularly suitable for modified bituminous binders. The paper deals with the comparison of the different input parameters set on the DSR device - different levels of stress, temperature of test, the geometry of the measuring device and also a comparison of the results for a different number of loading cycles. The research study was focused mainly on modified bituminous binders, but to compare the MSCR test it is performed even with conventional paving grade binders.

  15. Impact of power plant reliability on the choice of operating parameter values

    International Nuclear Information System (INIS)

    Kramer, R.A.

    1985-01-01

    In this thesis, the basic structure for the development of a methodology to evaluate the effect of operating parameters on plant availability and generating system economic dispatch optimization is described. Plant availability is determined by a fault free model. In this model historic, time dependent, component induced forced outage data is utilized as the basis for the calculation of projected plant forced outage rates. The influence of a particular fuel-cycle length at a specific generating station on the operational planning of a multi unit generating system is considered. The basis of the dispatch of units in this analysis is optimal economic operation, i.e., the minimization of the cost of reliability supplying electricity to the system's customers. As a result of the utilization of this technique, a simplified example that considers the choice between a 12- and 18-month fuel cycle length is evaluated in terms of its impact on plant availability, fuel cycle economics and overall optimal generating system economic dispatch. The reliability portion of this methodology is applied to a simplified representation of the recirculation system of a pressurized water reactor nuclear power plant to illustrate the analytic techniques

  16. An analysis of sensitivity of CLIMEX parameters in mapping species potential distribution and the broad-scale changes observed with minor variations in parameters values: an investigation using open-field Solanum lycopersicum and Neoleucinodes elegantalis as an example

    Science.gov (United States)

    da Silva, Ricardo Siqueira; Kumar, Lalit; Shabani, Farzin; Picanço, Marcelo Coutinho

    2018-04-01

    A sensitivity analysis can categorize levels of parameter influence on a model's output. Identifying parameters having the most influence facilitates establishing the best values for parameters of models, providing useful implications in species modelling of crops and associated insect pests. The aim of this study was to quantify the response of species models through a CLIMEX sensitivity analysis. Using open-field Solanum lycopersicum and Neoleucinodes elegantalis distribution records, and 17 fitting parameters, including growth and stress parameters, comparisons were made in model performance by altering one parameter value at a time, in comparison to the best-fit parameter values. Parameters that were found to have a greater effect on the model results are termed "sensitive". Through the use of two species, we show that even when the Ecoclimatic Index has a major change through upward or downward parameter value alterations, the effect on the species is dependent on the selection of suitability categories and regions of modelling. Two parameters were shown to have the greatest sensitivity, dependent on the suitability categories of each species in the study. Results enhance user understanding of which climatic factors had a greater impact on both species distributions in our model, in terms of suitability categories and areas, when parameter values were perturbed by higher or lower values, compared to the best-fit parameter values. Thus, the sensitivity analyses have the potential to provide additional information for end users, in terms of improving management, by identifying the climatic variables that are most sensitive.

  17. Different diagnostic values of imaging parameters to predict pseudoprogression in glioblastoma subgroups stratified by MGMT promoter methylation

    Energy Technology Data Exchange (ETDEWEB)

    Yoon, Ra Gyoung [Catholic Kwandong University International St. Mary' s Hospital, Department of Radiology, Catholic Kwandong University College of Medicine, Incheon (Korea, Republic of); Kim, Ho Sung; Shim, Woo Hyun; Kim, Sang Joon [University of Ulsan College of Medicine, Asan Medical Center, Department of Radiology and Research Institute of Radiology, Seoul (Korea, Republic of); Paik, Wooyul [Dankook Unversity Hospital, Department of Radiology, Cheonan-si, Chungcheongnam-do (Korea, Republic of); Kim, Jeong Hoon [University of Ulsan College of Medicine, Asan Medical Center, Department of Neurosurgery, Seoul (Korea, Republic of)

    2017-01-15

    The aim of this study was to determine whether diffusion and perfusion imaging parameters demonstrate different diagnostic values for predicting pseudoprogression between glioblastoma subgroups stratified by O{sup 6}-mythylguanine-DNA methyltransferase (MGMT) promoter methylation status. We enrolled seventy-five glioblastoma patients that had presented with enlarged contrast-enhanced lesions on magnetic resonance imaging (MRI) one month after completing concurrent chemoradiotherapy and undergoing MGMT promoter methylation testing. The imaging parameters included 10 or 90 % histogram cutoffs of apparent diffusion coefficient (ADC10), normalized cerebral blood volume (nCBV90), and initial area under the time signal-intensity curve (IAUC90). The results of the areas under the receiver operating characteristic curve (AUCs) with cross-validation were compared between MGMT methylation and unmethylation groups. MR imaging parameters demonstrated a trend toward higher accuracy in the MGMT promoter methylation group than in the unmethylation group (cross-validated AUCs = 0.70-0.95 and 0.56-0.87, respectively). The combination of MGMT methylation status with imaging parameters improved the AUCs from 0.70 to 0.75-0.90 for both readers in comparison with MGMT methylation status alone. The probability of pseudoprogression was highest (95.7 %) when nCBV90 was below 4.02 in the MGMT promoter methylation group. MR imaging parameters could be stronger predictors of pseudoprogression in glioblastoma patients with the methylated MGMT promoter than in patients with the unmethylated MGMT promoter. (orig.)

  18. The prognostic value of time parameters in adjuvant radiotherapy of head and neck cancer. A retrospective analysis of 138 patients

    International Nuclear Information System (INIS)

    Dietl, B.; Schaefer, C.; Koelbl, O.

    2005-01-01

    Purpose: to answer the question, how the parameters waiting time, radiation treatment time and overall treatment time (OTT) influenced the endpoints overall (OS), event-free (EFS) and local recurrence-free survival (LRFS) in patients with locally advanced head-and-neck cancer, who had received postoperative radiotherapy. Patients and methods: 138 patients were included into a retrospective analysis from 10/1993 to 05/2000. Besides the time parameters waiting time, radiation treatment time and OTT, tumor- and therapy-related parameters (T-, N-, R-status, grading, tumor site, surgical technique, and postoperative hemoglobin < 12 g/dl) with potential impact on the endpoints were investigated in the univariate analysis (Kaplan-Meier log-rank test). Individual parameters with a significant impact (p = 0.05) were subjected to a multivariate Cox regression analysis. Results: besides a postoperative hemoglobin value < 12 g/dl, in the univariate analysis an OTT ≥ 105 days negatively influenced all endpoints, as well as a radiation treatment time ≥ 60 days. On multivariate Cox regression analysis, postoperative hemoglobin < 12 g/dl and an OTT ≥ 105 days were identified as independent negative prognostic factors for all endpoints. Conclusion: the waiting time should be managed according to the ASARA (as short as reasonably achievable) recommendation, radiation treatment should not be protracted exceeding an overall treatment of 105 days. Generally, time parameters should be routinely included in the standard tumor documentation, thus facilitating further evaluation of these prognostically relevant factors. (orig.)

  19. Towards all-order Laurent expansion of generalized hypergeometric functions around rational values of parameters

    Energy Technology Data Exchange (ETDEWEB)

    Kalmykov, M.Yu.; Kniehl, B.A. [Hamburg Univ. (Germany). 2. Inst. fuer Theoretische Physik

    2008-07-15

    We prove the following theorems: 1) The Laurent expansions in {epsilon} of the Gauss hypergeometric functions {sub 2}F{sub 1}(I{sub 1}+a{epsilon},I{sub 2}+b{epsilon};I{sub 3}+(p)/(q)+c{epsilon};z), {sub 2}F{sub 1}(I{sub 1}+(p)/(q)+a{epsilon},I{sub 2}+(p/q)+b{epsilon};I{sub 3}+(p)/(q)+c{epsilon};z) and {sub 2}F{sub 1}(I{sub 1}+(p)/(q)+ a{epsilon},I{sub 2}+b{epsilon};I{sub 3}+(p)/(q)+c{epsilon};z), where I{sub 1},I{sub 2},I{sub 3},p,q are arbitrary integers, a,b,c are arbitrary numbers and {epsilon} is an infinitesimal parameter, are expressible in terms of multiple polylogarithms of q-roots of unity with coefficients that are ratios of polynomials; 2) The Laurent expansion of the Gauss hypergeometric function {sub 2}F{sub 1}(I{sub 1}+(p)/(q)+a{epsilon},I{sub 2}+b{epsilon};I{sub 3}+c{epsilon};z) is expressible in terms of multiple polylogarithms of q-roots of unity times powers of logarithm with coefficients that are ratios of polynomials; 3) The multiple inverse rational sums {sigma}{sup {infinity}}{sub j=1}({gamma}(j))/({gamma}(1+j-(p)/(q))) (z{sup j})/(j{sup c}) S{sub a{sub 1}}(j-1).. S{sub a{sub p}}(j-1) and the multiple rational sums {sigma}{sup {infinity}}{sub j=1} ({gamma}(j+(p)/(q)))/({gamma}(1+j)) (z{sup j})/(j{sup c}) S{sub a{sub 1}}(j-1).. S{sub a{sub p}}(j-1), where S{sub a}(j)={sigma}{sup j}{sub k=1}(1)/(k{sup a}) is a harmonic series and c is an arbitrary integer, are expressible in terms of multiple polylogarithms; 4) The generalized hypergeometric functions {sub p}F{sub p.1}((vector)A+(vector)a{epsilon};(vector)B+(vector)b{epsilon},(p)/(q)+B{sub p-1};z) and {sub p}F{sub p-1}((vector)A+(vector)a{epsilon},(p)/(q)+A{sub p};(vector)B+(vector)b{epsilon};z) are expressible in terms of multiple polylogarithms with coefficients that are ratios of polynomials. (orig.)

  20. Syphilis and neurosyphilis: HIV-coinfection and value of diagnostic parameters in cerebrospinal fluid.

    Science.gov (United States)

    Merins, V; Hahn, K

    2015-10-07

    Neurosyphilis might be difficult to diagnose particularly in asymptomatic patients and patients with HIV-coinfection. The objective of this study was to evaluate current diagnostic standards for neurosyphilis in HIV-positive and -negative patients. We studied retrospectively patients with an active syphilis infection who had additionally undergone lumbar puncture. Patients where the criteria for the diagnosis of a definite or probable neurosyphilis were applicable were further analyzed for clinical symptoms, CSF, HIV-status as well as Treponema pallidum testing in serum and CSF. Correlation analysis of categorical variables was done by using the Chi-square test or in cases of small sample sizes the exact test of Fisher. p values ≤0.05 were considered significant. Eighty-nine patients were diagnosed with syphilis. All necessary criteria for the diagnosis of a neurosyphilis were available in 67 of them including 35 HIV-positive and 32 HIV-negative patients. A definite neurosyphilis could be retrospectively diagnosed in 13 and a probable in another 25 cases. Normal CSF results were more likely in HIV-negatives (p = 0.016). A neurosyphilis was correlated to a CSF pleocytosis > 5 cells/µl and to an albumin quotient >7.8 mg/dl regardless of a parallel HIV infection. HIV-positives had more frequently a CSF-RPR titre >1:4 than HIV-negatives (p = 0.031). However, the RPR test in CSF in definite or probable neurosyphilis had a sensitivity of only 21 %. Our data show that a pleocytosis and an elevated albumin quotient correlate with neurosyphilis. However, the CSF-RPR test as gold standard in neurosyphilis diagnostics has a very low sensitivity.

  1. Parameter values for epidemiological models of foot-and-mouth disease in swine

    Directory of Open Access Journals (Sweden)

    Amy C Kinsley

    2016-06-01

    Full Text Available In the event of a foot-and-mouth disease (FMD incursion, response strategies are required to control, contain and eradicate the pathogen as efficiently as possible. Infectious disease simulation models are widely used tools that mimic disease dispersion in a population and that can be useful in the design and support of prevention and mitigation activities. However, there are often gaps in evidence-based research to supply models with quantities that are necessary to accurately reflect the system of interest. The objective of this study was to quantify values associated with the duration of the stages of FMD infection (latent period, subclinical period, incubation period, and duration of infection, probability of transmission (within-herd and between-herd via spatial spread, and diagnosis of a vesicular disease within a herd using a meta-analysis of the peer-reviewed literature and expert opinion. The latent period ranged from 1 to 7 days and incubation period ranged from 1 to 9 day; both were influenced by strain. In contrast, the subclinical period ranged from 0 to 6 days and was influenced by sampling method only. The duration of infection ranged from 1 to 10 days. The probability of spatial spread between an infected and fully susceptible swine farm was estimated as greatest within 5 km of the infected farm, highlighting the importance of possible long-range transmission through the movement of infected animals. Lastly, while most swine practitioners are confident in their ability to detect a vesicular disease in an average sized swine herd, a small proportion expect that up to half of the herd would need to show clinical signs before detection via passive surveillance would occur. The results of this study will be useful in within- and between-herd simulation models to develop efficient response strategies in the event an FMD in swine populations of disease-free countries or regions.

  2. Calculation of the number of branches of multi-valued decision trees in computer aided importance rank of parameters

    Directory of Open Access Journals (Sweden)

    Tiszbierek Agnieszka

    2017-01-01

    Full Text Available An elaborated digital computer programme supporting the time-consuming process of selecting the importance rank of construction and operation parameters by means of stating optimum sets is based on the Quine – McCluskey algorithm of minimizing individual partial multi-valued logic functions. The example with real time data, calculated by means of the programme, showed that among the obtained optimum sets there were such which had a different number of real branches after being presented on the multi-valued logic decision tree. That is why an idea of elaborating another functionality of the programme – a module calculating the number of branches of real, multi-valued logic decision trees presenting optimum sets chosen by the programme was pursued. This paper presents the idea and the method for developing a module calculating the number of branches, real for each of optimum sets indicated by the programme, as well as to the calculation process.

  3. IMPACT STUDY OF ANISOTROPIC OPTICAL FIBERS WINDING WITH DIFFERENT TENSION VALUE ON THE H-PARAMETER INVARIANCE DEGREE

    Directory of Open Access Journals (Sweden)

    A. B. Mukhtubayev

    2015-09-01

    Full Text Available Subject of Research. We have investigated the effect of anisotropic optical fibers winding with an elliptical sheath subjecting to stress on the H-parameter invariance degree. This type of optical fiber is used in the manufacture of fiber loop in fiber-optic gyroscopes. Method of Research. The method of research is based on the application of Michelson polarization scanning interferometer as a measuring device. Superluminescent diode with a central wavelength of 1575 nm and a half-width of the spectrum equal to 45 nm is used as a radiation source. The studies were carried out with anisotropic optical fiber with 50 m long elliptical sheath subjecting to stress. The fiber was wound with one layer turn to turn on the coil with a diameter of 18 cm, which is used in the design of fiber-optic gyroscope. The tension force of the optical fiber was controlled during winding on a special machine. Main Results. It was found that at the increase of tension force from 0.05 N to 0.8 H the value of H-parameter increases from 7×10-6 1/m up to 178×10-6 1/m, respectively; i.e. the coupling coefficient of orthogonal modes in the test fiber is being increased. Thus, it is necessary to consider the longitudinal tension force of fiber in the design and manufacture of the fiber-optic sensors of high accuracy class: the less the fiber winding power, the higher invariance degree of distributed H-parameter. The longitudinal tension force of anisotropic optical fiber with elliptical sheath subjecting to stress equal to 0.2 N is recommended in the process of designing fiber-optic gyroscopes. Practical Relevance. The proposed method of Michelson scanning interferometer is usable in the production process for quality determination of the optical fiber winding: no local defects, value controlling of fiber H-parameter.

  4. Evaluation of Physico-chemical Parameters of Manchar Lake Water and Their Comparison with Other Global Published Values

    Directory of Open Access Journals (Sweden)

    Muhammad Balal Arain

    2008-12-01

    Full Text Available The aim of current study was to evaluate the status of the Manchar lake water with respect to different physico-chemical parameters (electric conductivity, pH, chloride, phosphate, sulfate, total alkalinity, potassium, calcium, magnesium, manganese, iron, cadmium, copper, arsenic, nickel, zinc, chromium lead and selenium in 2005-2007. Among the elemental investigation of Manchar Lake water except Co, Cr, Cu and Mn, other elements (Al, As, Ca, Cd, Fe, Mg, Na, K, Ni, Pb and Se have higher values as compared to the permissible level of these elements in drinking water. The results were compared with WHO water quality guidelines as well as with literature values reported for global lake water.

  5. A meaningful workplace: Framework, space and context ...

    African Journals Online (AJOL)

    A meaningful workplace: Framework, space and context. ... PL Steenkamp, JS Basson ... The organisation experiences a loss of productivity, quality, innovation, et cetera ... This is what this article is about: to conceptualise the workplace as ...

  6. Making Social Studies Meaningful to Elementary Students.

    Science.gov (United States)

    Klein, Susan

    1982-01-01

    Describes a unit on Ancient Greece designed to make social studies meaningful to fourth and fifth graders. Individual projects and group activities helped students learn about ancient Greek culture. (AM)

  7. A Study of the Historical Earthquake Catalog and Gutenberg-richter Parameter Values of the Korean Peninsula

    International Nuclear Information System (INIS)

    Seo, Jeong Moon; Choi, In Kil; Rhee, Hyun Me

    2010-01-01

    The KIER's Korean historical earthquake catalog was revised for MMI≥VI events recorded from the years 27 A.D. to 1904. The magnitude of each event was directly determined from the criteria suggested by Seo. The criteria incorporated the damage phenomena of the Japanese historical earthquake catalog, recent seismological studies, and the results of tests performed on ancient structures in Korea. Thus, the uncertainty of the magnitudes of the Korean historical earthquakes can be reduced. Also, the Gutenberg-Richter parameter values were estimated based on the revised catalog of this study. It was determined that the magnitudes of a maximum inland and minimum offshore event were approximately 6.3 and 6.5, respectively. The Gutenberg-Richter parameter pairs of the historical earthquake catalog were estimated to be a=5.32±0.21, b=0.95±0.19, which were somewhat lower than those obtained from recent complete instrumental earthquakes. No apparent change in the Gutenberg-Richter parameter is observed for the 16 th -17 th centuries of the seismically active period

  8. Blood coagulation parameters and platelet indices: changes in normal and preeclamptic pregnancies and predictive values for preeclampsia.

    Directory of Open Access Journals (Sweden)

    Lei Han

    Full Text Available Preeclampsia (PE is an obstetric disorder with high morbidity and mortality rates but without clear pathogeny. The dysfunction of the blood coagulation-fibrinolysis system is a salient characteristic of PE that varies in severity, and necessitates different treatments. Therefore, it is necessary to find suitable predictors for the onset and severity of PE.We aimed to evaluate blood coagulation parameters and platelet indices as potential predictors for the onset and severity of PE.Blood samples from 3 groups of subjects, normal pregnant women (n = 79, mild preeclampsia (mPE (n = 53 and severe preeclampsia (sPE (n = 42, were collected during early and late pregnancy. The levels of coagulative parameters and platelet indices were measured and compared among the groups. The receiver-operating characteristic (ROC curves of these indices were generated, and the area under the curve (AUC was calculated. The predictive values of the selected potential parameters were examined in binary regression analysis.During late pregnancy in the normal pregnancy group, the activated partial thromboplastin time (APTT, prothrombin time (PT, thrombin time (TT and platelet count decreased, while the fibrinogen level and mean platelet volume (MPV increased compared to early pregnancy (p<0.05. However, the PE patients presented with increased APTT, TT, MPV and D-dimer (DD during the third trimester. In the analysis of subjects with and without PE, TT showed the largest AUC (0.743 and high predictive value. In PE patients with different severities, MPV showed the largest AUC (0.671 and ideal predictive efficiency.Normal pregnancy causes a maternal physiological hypercoagulable state in late pregnancy. PE may trigger complex disorders in the endogenous coagulative pathways and consume platelets and FIB, subsequently activating thrombopoiesis and fibrinolysis. Thrombin time and MPV may serve as early monitoring markers for the onset and severity of PE

  9. Concept maps and the meaningful learning of science

    Directory of Open Access Journals (Sweden)

    José Antonio C. S. Valadares

    2013-03-01

    Full Text Available The foundations of the Meaningful Learning Theory (MLT were laid by David Ausubel. The MLT was highly valued by the contributions of Joseph Novak and D. B. Gowin. Unlike other learning theories, the MLT has an operational component, since there are some instruments based on it and with the meaningful learning facilitation as aim. These tools were designated graphic organizers by John Trowbridge and James Wandersee (2000, pp. 100-129. One of them is the concept map created by Novak to extract meanings from an amalgam of information, having currently many applications. The other one is the Vee diagram or knowledge Vee, also called epistemological Vee or heuristic Vee. It was created by Gowin, and is an excellent organizer, for example to unpack and make transparent the unclear information from an information source. Both instruments help us in processing and becoming conceptually transparent the information, to facilitate the cognitive process of new meanings construction. In this work, after a brief introduction, it will be developed the epistemological and psychological grounds of MLT, followed by a reference to constructivist learning environments facilitators of the meaningful learning, the characterization of concept maps and exemplification of its use in various applications that have proved to be very effective from the standpoint of meaningful learning.

  10. The Use of Asymptotic Functions for Determining Empirical Values of CN Parameter in Selected Catchments of Variable Land Cover

    Science.gov (United States)

    Wałęga, Andrzej; Młyński, Dariusz; Wachulec, Katarzyna

    2017-12-01

    The aim of the study was to assess the applicability of asymptotic functions for determining the value of CN parameter as a function of precipitation depth in mountain and upland catchments. The analyses were carried out in two catchments: the Rudawa, left tributary of the Vistula, and the Kamienica, right tributary of the Dunajec. The input material included data on precipitation and flows for a multi-year period 1980-2012, obtained from IMGW PIB in Warsaw. Two models were used to determine empirical values of CNobs parameter as a function of precipitation depth: standard Hawkins model and 2-CN model allowing for a heterogeneous nature of a catchment area. The study analyses confirmed that asymptotic functions properly described P-CNobs relationship for the entire range of precipitation variability. In the case of high rainfalls, CNobs remained above or below the commonly accepted average antecedent moisture conditions AMCII. The study calculations indicated that the runoff amount calculated according to the original SCS-CN method might be underestimated, and this could adversely affect the values of design flows required for the design of hydraulic engineering projects. In catchments with heterogeneous land cover, the results of CNobs were more accurate when 2-CN model was used instead of the standard Hawkins model. 2-CN model is more precise in accounting for differences in runoff formation depending on retention capacity of the substrate. It was also demonstrated that the commonly accepted initial abstraction coefficient λ = 0.20 yielded too big initial loss of precipitation in the analyzed catchments and, therefore, the computed direct runoff was underestimated. The best results were obtained for λ = 0.05.

  11. Predictive significance of standardized uptake value parameters of FDG-PET in patients with non-small cell lung carcinoma

    Energy Technology Data Exchange (ETDEWEB)

    Duan, X-Y.; Wang, W.; Li, M.; Li, Y.; Guo, Y-M. [PET-CT Center, The First Affiliated Hospital of Xi' an, Jiaotong University, Xi' an, Shaanxi (China)

    2015-02-03

    {sup 18}F-fluoro-2-deoxyglucose (FDG) positron emission tomography (PET)/computed tomography (CT) is widely used to diagnose and stage non-small cell lung cancer (NSCLC). The aim of this retrospective study was to evaluate the predictive ability of different FDG standardized uptake values (SUVs) in 74 patients with newly diagnosed NSCLC. {sup 18}F-FDG PET/CT scans were performed and different SUV parameters (SUV{sub max}, SUV{sub avg}, SUV{sub T/L}, and SUV{sub T/A}) obtained, and their relationship with clinical characteristics were investigated. Meanwhile, correlation and multiple stepwise regression analyses were performed to determine the primary predictor of SUVs for NSCLC. Age, gender, and tumor size significantly affected SUV parameters. The mean SUVs of squamous cell carcinoma were higher than those of adenocarcinoma. Poorly differentiated tumors exhibited higher SUVs than well-differentiated ones. Further analyses based on the pathologic type revealed that the SUV{sub max}, SUV{sub avg}, and SUV{sub T/L} of poorly differentiated adenocarcinoma tumors were higher than those of moderately or well-differentiated tumors. Among these four SUV parameters, SUV{sub T/L} was the primary predictor for tumor differentiation. However, in adenocarcinoma, SUV{sub max} was the determining factor for tumor differentiation. Our results showed that these four SUV parameters had predictive significance related to NSCLC tumor differentiation; SUV{sub T/L} appeared to be most useful overall, but SUV{sub max} was the best index for adenocarcinoma tumor differentiation.

  12. Lattice parameters values and phase diagram for the Cu2Zn1-zFezGeSe4 alloy system

    International Nuclear Information System (INIS)

    Caldera, D.; Quintero, M.; Morocoima, M.; Quintero, E.; Grima, P.; Marchan, N.; Moreno, E.; Bocaranda, P.; Delgado, G.E.; Mora, A.E.; Briceno, J.M.; Fernandez, J.L.

    2008-01-01

    X-ray powder diffraction and differential thermal analysis (DTA) measurements were made on polycrystalline samples of the Cu 2 Zn 1-z Fe z GeSe 4 alloy system. The diffraction patterns were used to show the equilibrium conditions and to estimate crystalline parameter values. It was found that, at room temperature, a single phase solid solution with the tetragonal stannite α structure (I4-bar2m) occurs across the whole composition range. The DTA thermograms were used to construct the phase diagram of the Cu 2 Zn 1-z Fe z GeSe 4 alloy system. It was confirmed that the Cu 2 ZnGeSe 4 compound melts incongruently. It was observed that undercooling effects occur for samples with z > 0.9

  13. Determination of the exact range of the value of the parameter corresponding to chaos based on the Silnikov criterion

    International Nuclear Information System (INIS)

    Wei-Yi, Li; Qi-Chang, Zhang; Wei, Wang

    2010-01-01

    Based on the Silnikov criterion, this paper studies a chaotic system of cubic polynomial ordinary differential equations in three dimensions. Using the Cardano formula, it obtains the exact range of the value of the parameter corresponding to chaos by means of the centre manifold theory and the method of multiple scales combined with Floque theory. By calculating the manifold near the equilibrium point, the series expression of the homoclinic orbit is also obtained. The space trajectory and Lyapunov exponent are investigated via numerical simulation, which shows that there is a route to chaos through period-doubling bifurcation and that chaotic attractors exist in the system. The results obtained here mean that chaos occurred in the exact range given in this paper. Numerical simulations also verify the analytical results. (general)

  14. Bifurcation and Stability Analysis of the Equilibrium States in Thermodynamic Systems in a Small Vicinity of the Equilibrium Values of Parameters

    Science.gov (United States)

    Barsuk, Alexandr A.; Paladi, Florentin

    2018-04-01

    The dynamic behavior of thermodynamic system, described by one order parameter and one control parameter, in a small neighborhood of ordinary and bifurcation equilibrium values of the system parameters is studied. Using the general methods of investigating the branching (bifurcations) of solutions for nonlinear equations, we performed an exhaustive analysis of the order parameter dependences on the control parameter in a small vicinity of the equilibrium values of parameters, including the stability analysis of the equilibrium states, and the asymptotic behavior of the order parameter dependences on the control parameter (bifurcation diagrams). The peculiarities of the transition to an unstable state of the system are discussed, and the estimates of the transition time to the unstable state in the neighborhood of ordinary and bifurcation equilibrium values of parameters are given. The influence of an external field on the dynamic behavior of thermodynamic system is analyzed, and the peculiarities of the system dynamic behavior are discussed near the ordinary and bifurcation equilibrium values of parameters in the presence of external field. The dynamic process of magnetization of a ferromagnet is discussed by using the general methods of bifurcation and stability analysis presented in the paper.

  15. Meaningful Interaction in a Local Context

    DEFF Research Database (Denmark)

    Holck, Ulla

    2006-01-01

    This keynote is based on a Ph.D. thesis on development of socially meaningful interaction in music therapy with children with very poor communication skills (Holck 2002). The aim was to identify some of the conditions, whereby actions can be understood as meaningful - that is, whereby the child......’ Samspil i Musikterapi [Eng.: ’Commusical’ Interplay in Music Therapy. Qualitative Video Analyses of Musical and Gestural Interactions with Children with Severe Functional Limitations, including Children with Autism]. Unpubl. PhD thesis, Aalborg Universitet. Holck, U. (2004) Interaction Themes in Music...

  16. [Temporal and spatial heterogeneity analysis of optimal value of sensitive parameters in ecological process model: The BIOME-BGC model as an example.

    Science.gov (United States)

    Li, Yi Zhe; Zhang, Ting Long; Liu, Qiu Yu; Li, Ying

    2018-01-01

    The ecological process models are powerful tools for studying terrestrial ecosystem water and carbon cycle at present. However, there are many parameters for these models, and weather the reasonable values of these parameters were taken, have important impact on the models simulation results. In the past, the sensitivity and the optimization of model parameters were analyzed and discussed in many researches. But the temporal and spatial heterogeneity of the optimal parameters is less concerned. In this paper, the BIOME-BGC model was used as an example. In the evergreen broad-leaved forest, deciduous broad-leaved forest and C3 grassland, the sensitive parameters of the model were selected by constructing the sensitivity judgment index with two experimental sites selected under each vegetation type. The objective function was constructed by using the simulated annealing algorithm combined with the flux data to obtain the monthly optimal values of the sensitive parameters at each site. Then we constructed the temporal heterogeneity judgment index, the spatial heterogeneity judgment index and the temporal and spatial heterogeneity judgment index to quantitatively analyze the temporal and spatial heterogeneity of the optimal values of the model sensitive parameters. The results showed that the sensitivity of BIOME-BGC model parameters was different under different vegetation types, but the selected sensitive parameters were mostly consistent. The optimal values of the sensitive parameters of BIOME-BGC model mostly presented time-space heterogeneity to different degrees which varied with vegetation types. The sensitive parameters related to vegetation physiology and ecology had relatively little temporal and spatial heterogeneity while those related to environment and phenology had generally larger temporal and spatial heterogeneity. In addition, the temporal heterogeneity of the optimal values of the model sensitive parameters showed a significant linear correlation

  17. Students' Meaningful Learning Orientation and Their Meaningful Understandings of Meiosis and Genetics.

    Science.gov (United States)

    Cavallo, Ann Liberatore

    This 1-week study explored the extent to which high school students (n=140) acquired meaningful understanding of selected biological topics (meiosis and the Punnett square method) and the relationship between these topics. This study: (1) examined "mental modeling" as a technique for measuring students' meaningful understanding of the…

  18. Forecasting Kp from solar wind data: input parameter study using 3-hour averages and 3-hour range values

    Science.gov (United States)

    Wintoft, Peter; Wik, Magnus; Matzka, Jürgen; Shprits, Yuri

    2017-11-01

    We have developed neural network models that predict Kp from upstream solar wind data. We study the importance of various input parameters, starting with the magnetic component Bz, particle density n, and velocity V and then adding total field B and the By component. As we also notice a seasonal and UT variation in average Kp we include functions of day-of-year and UT. Finally, as Kp is a global representation of the maximum range of geomagnetic variation over 3-hour UT intervals we conclude that sudden changes in the solar wind can have a big effect on Kp, even though it is a 3-hour value. Therefore, 3-hour solar wind averages will not always appropriately represent the solar wind condition, and we introduce 3-hour maxima and minima values to some degree address this problem. We find that introducing total field B and 3-hour maxima and minima, derived from 1-minute solar wind data, have a great influence on the performance. Due to the low number of samples for high Kp values there can be considerable variation in predicted Kp for different networks with similar validation errors. We address this issue by using an ensemble of networks from which we use the median predicted Kp. The models (ensemble of networks) provide prediction lead times in the range 20-90 min given by the time it takes a solar wind structure to travel from L1 to Earth. Two models are implemented that can be run with real time data: (1) IRF-Kp-2017-h3 uses the 3-hour averages of the solar wind data and (2) IRF-Kp-2017 uses in addition to the averages, also the minima and maxima values. The IRF-Kp-2017 model has RMS error of 0.55 and linear correlation of 0.92 based on an independent test set with final Kp covering 2 years using ACE Level 2 data. The IRF-Kp-2017-h3 model has RMSE = 0.63 and correlation = 0.89. We also explore the errors when tested on another two-year period with real-time ACE data which gives RMSE = 0.59 for IRF-Kp-2017 and RMSE = 0.73 for IRF-Kp-2017-h3. The errors as function

  19. THE REFERENCE VALUES OF THE MAIN BIOCHEMICAL PARAMETERS OF THE HEMOLYMPH OF APIS MELLIFERA CARPATHICA IN SOUTH-EASTERN ROMANIA

    Directory of Open Access Journals (Sweden)

    AGRIPINA SAPCALIU

    2007-10-01

    Full Text Available Although biochemical analyses of the blood were and are still used for the routinediagnosis and especially for the metabolic survey in farm animals, such analyses, maybe applied for the honeybee hemolymph (as a paraclinic examination. The aim of thisexperimental study was to investigate and to determine the reference values of themain biochemical parameters in the hemolymph of the healthy honeybees of Apismellifera carpathica. The honeybee samples were collected in order to analyze thehealth condition of the respective colony. All the samples coming from sick colonieswere removed, only healthy adult honeybees coming from strong colonies were keptand used for hemolymph collection. By special methods, samples of hemolymph (300μl/sample collected from about 50 individuals, were analyzed both during the activeseason (spring/summer and the inactive season (autumn/winter. The study wascarried out on 50 samples of undiluted hemolymph taken from a total number of about2,500 honeybees. The following 21 biochemical parameters were analyzed: GLU(mg/dl, HDL-c (mg/dl, ALP (UI/l, T-cho (mg/dl, Tprot (mg/dl, Alb. (g/dl, BUN(mg/dl, LDH (UI/l, CPK (UI/l, Mg (mg/dl, FRA (μm/l, IP (mg/dl, GGT (UI/l,GOT (UI/l, GPT (UI/l, Ca (mg/dl, Cre (mg/dl, Amy (UI/l, T–BIL (mg/dl, TG(mg/dl, UA (mg/dl. The test was carried out after the collection and processing of thesamples using the SPOTCHEM EZSP4430, equipment with dry kits, the slides technique,respectively.

  20. Prognostic value of preoperative dynamic contrast-enhanced MRI perfusion parameters for high-grade glioma patients

    Energy Technology Data Exchange (ETDEWEB)

    Ulyte, Agne [Vilnius University, Faculty of Medicine, Vilnius (Lithuania); Katsaros, Vasileios K. [General Anticancer and Oncological Hospital ' ' St. Savvas' ' , Department of Advanced Imaging Modalities - CT and MRI, Athens (Greece); University of Athens, Department of Neurosurgery, Evangelismos Hospital, Athens (Greece); Liouta, Evangelia; Stranjalis, Georgios [University of Athens, Department of Neurosurgery, Evangelismos Hospital, Athens (Greece); Boskos, Christos [University of Athens, Department of Neurosurgery, Evangelismos Hospital, Athens (Greece); General Anticancer and Oncological Hospital ' ' St. Savvas' ' , Department of Radiation Oncology, Athens (Greece); Papanikolaou, Nickolas [Champalimaud Foundation, Department of Radiology, Centre for the Unknown, Lisbon (Portugal); Usinskiene, Jurgita [National Cancer Institute, Vilnius (Lithuania); Affidea Lietuva, Vilnius (Lithuania); Bisdas, Sotirios [University College London Hospitals, Department of Neuroradiology, The National Hospital for Neurology and Neurosurgery, London (United Kingdom)

    2016-12-15

    The prognostic value of the dynamic contrast-enhanced (DCE) MRI perfusion and its histogram analysis-derived metrics is not well established for high-grade glioma (HGG) patients. The aim of this prospective study was to investigate DCE perfusion transfer coefficient (K{sup trans}), vascular plasma volume fraction (v{sub p}), extracellular volume fraction (v{sub e}), reverse transfer constant (k{sub ep}), and initial area under gadolinium concentration time curve (IAUGC) as predictors of progression-free (PFS) and overall survival (OS) in HGG patients. Sixty-nine patients with suspected anaplastic astrocytoma or glioblastoma underwent preoperative DCE-MRI scans. DCE perfusion whole tumor region histogram parameters, clinical details, and PFS and OS data were obtained. Univariate, multivariate, and Kaplan-Meier survival analyses were conducted. Receiver operating characteristic (ROC) curve analysis was employed to identify perfusion parameters with the best differentiation performance. On univariate analysis, v{sub e} and skewness of v{sub p} had significant negative impacts, while k{sub ep} had significant positive impact on OS (P < 0.05). v{sub e} was also a negative predictor of PFS (P < 0.05). Patients with lower v{sub e} and IAUGC had longer median PFS and OS on Kaplan-Meier analysis (P < 0.05). K{sup trans} and v{sub e} could also differentiate grade III from IV gliomas (area under the curve 0.819 and 0.791, respectively). High v{sub e} is a consistent predictor of worse PFS and OS in HGG glioma patients. v{sub p} skewness and k{sub ep} are also predictive for OS. K{sup trans} and v{sub e} demonstrated the best diagnostic performance for differentiating grade III from IV gliomas. (orig.)

  1. Remedial principles and meaningful engagement in education ...

    African Journals Online (AJOL)

    This article evaluates the meaningful engagement doctrine in the education rights jurisprudence of the Constitutional Court in the light of a set of normative principles developed by Susan Sturm for evaluating participatory public law remedies. It commences by identifying four principles for evaluating participatory remedies ...

  2. Meaningful Learning in the Cooperative Classroom

    Science.gov (United States)

    Sharan, Yael

    2015-01-01

    Meaningful learning is based on more than what teachers transmit; it promotes the construction of knowledge out of learners' experience, feelings and exchanges with other learners. This educational view is based on the constructivist approach to learning and the co-operative learning approach. Researchers and practitioners in various…

  3. Meaningful Use of School Health Data

    Science.gov (United States)

    Johnson, Kathleen Hoy; Bergren, Martha Dewey

    2011-01-01

    Meaningful use (MU) of Electronic Health Records (EHRs) is an important development in the safety and security of health care delivery in the United States. Advancement in the use of EHRs occurred with the passage of the American Recovery and Reinvestment Act of 2009, which provides incentives for providers to support adoption and use of EHRs.…

  4. Wonderful Life : Exploring Wonder in Meaningful Moments

    NARCIS (Netherlands)

    van de Goor, Marie Jacqueline; Sools, Anna Maria; Westerhof, Gerben Johan; Bohlmeijer, Ernst Thomas

    In this article, we bring the study of meaning together with the emerging field of study focusing on the emotions of wonder: wonder, enchantment, awe, and being moved. It is in meaningful moments that these two meet, and in our empirical study, we used the emotions of wonder as a lens to investigate

  5. Assessing Assessment: In Pursuit of Meaningful Learning

    Science.gov (United States)

    Rootman-le Grange, Ilse; Blackie, Margaret A. L.

    2018-01-01

    The challenge of supporting the development of meaningful learning is prevalent in chemistry education research. One of the core activities used in the learning process is assessments. The aim of this paper is to illustrate how the semantics dimension of Legitimation Code Theory can be a helpful tool to critique the quality of assessments and…

  6. Fishing for meaningful units in connected speech

    DEFF Research Database (Denmark)

    Henrichsen, Peter Juel; Christiansen, Thomas Ulrich

    2009-01-01

    In many branches of spoken language analysis including ASR, the set of smallest meaningful units of speech is taken to coincide with the set of phones or phonemes. However, fishing for phones is difficult, error-prone, and computationally expensive. We present an experiment, based on machine...

  7. Contrast-enhanced 3T MR Perfusion of Musculoskeletal Tumours: T1 Value Heterogeneity Assessment and Evaluation of the Influence of T1 Estimation Methods on Quantitative Parameters.

    Science.gov (United States)

    Gondim Teixeira, Pedro Augusto; Leplat, Christophe; Chen, Bailiang; De Verbizier, Jacques; Beaumont, Marine; Badr, Sammy; Cotten, Anne; Blum, Alain

    2017-12-01

    To evaluate intra-tumour and striated muscle T1 value heterogeneity and the influence of different methods of T1 estimation on the variability of quantitative perfusion parameters. Eighty-two patients with a histologically confirmed musculoskeletal tumour were prospectively included in this study and, with ethics committee approval, underwent contrast-enhanced MR perfusion and T1 mapping. T1 value variations in viable tumour areas and in normal-appearing striated muscle were assessed. In 20 cases, normal muscle perfusion parameters were calculated using three different methods: signal based and gadolinium concentration based on fixed and variable T1 values. Tumour and normal muscle T1 values were significantly different (p = 0.0008). T1 value heterogeneity was higher in tumours than in normal muscle (variation of 19.8% versus 13%). The T1 estimation method had a considerable influence on the variability of perfusion parameters. Fixed T1 values yielded higher coefficients of variation than variable T1 values (mean 109.6 ± 41.8% and 58.3 ± 14.1% respectively). Area under the curve was the least variable parameter (36%). T1 values in musculoskeletal tumours are significantly different and more heterogeneous than normal muscle. Patient-specific T1 estimation is needed for direct inter-patient comparison of perfusion parameters. • T1 value variation in musculoskeletal tumours is considerable. • T1 values in muscle and tumours are significantly different. • Patient-specific T1 estimation is needed for comparison of inter-patient perfusion parameters. • Technical variation is higher in permeability than semiquantitative perfusion parameters.

  8. Contrast-enhanced 3T MR perfusion of musculoskeletal tumours. T1 value heterogeneity assessment and evaluation of the influence of T1 estimation methods on quantitative parameters

    Energy Technology Data Exchange (ETDEWEB)

    Gondim Teixeira, Pedro Augusto; Leplat, Christophe; Verbizier, Jacques de; Blum, Alain [Hopital Central, CHRU-Nancy, Service d' Imagerie Guilloz, Nancy (France); Chen, Bailiang; Beaumont, Marine [Universite de Lorraine, Laboratoire IADI, UMR S 947, Nancy (France); Badr, Sammy; Cotten, Anne [CHRU Lille Centre de Consultations et d' Imagerie de l' Appareil Locomoteur, Department of Radiology and Musculoskeletal Imaging, Lille (France)

    2017-12-15

    To evaluate intra-tumour and striated muscle T1 value heterogeneity and the influence of different methods of T1 estimation on the variability of quantitative perfusion parameters. Eighty-two patients with a histologically confirmed musculoskeletal tumour were prospectively included in this study and, with ethics committee approval, underwent contrast-enhanced MR perfusion and T1 mapping. T1 value variations in viable tumour areas and in normal-appearing striated muscle were assessed. In 20 cases, normal muscle perfusion parameters were calculated using three different methods: signal based and gadolinium concentration based on fixed and variable T1 values. Tumour and normal muscle T1 values were significantly different (p = 0.0008). T1 value heterogeneity was higher in tumours than in normal muscle (variation of 19.8% versus 13%). The T1 estimation method had a considerable influence on the variability of perfusion parameters. Fixed T1 values yielded higher coefficients of variation than variable T1 values (mean 109.6 ± 41.8% and 58.3 ± 14.1% respectively). Area under the curve was the least variable parameter (36%). T1 values in musculoskeletal tumours are significantly different and more heterogeneous than normal muscle. Patient-specific T1 estimation is needed for direct inter-patient comparison of perfusion parameters. (orig.)

  9. Meaningful Human Control over Autonomous Systems: A Philosophical Account

    Directory of Open Access Journals (Sweden)

    Filippo Santoni de Sio

    2018-02-01

    Full Text Available Debates on lethal autonomous weapon systems have proliferated in the past 5 years. Ethical concerns have been voiced about a possible raise in the number of wrongs and crimes in military operations and about the creation of a “responsibility gap” for harms caused by these systems. To address these concerns, the principle of “meaningful human control” has been introduced in the legal–political debate; according to this principle, humans not computers and their algorithms should ultimately remain in control of, and thus morally responsible for, relevant decisions about (lethal military operations. However, policy-makers and technical designers lack a detailed theory of what “meaningful human control” exactly means. In this paper, we lay the foundation of a philosophical account of meaningful human control, based on the concept of “guidance control” as elaborated in the philosophical debate on free will and moral responsibility. Following the ideals of “Responsible Innovation” and “Value-sensitive Design,” our account of meaningful human control is cast in the form of design requirements. We identify two general necessary conditions to be satisfied for an autonomous system to remain under meaningful human control: first, a “tracking” condition, according to which the system should be able to respond to both the relevant moral reasons of the humans designing and deploying the system and the relevant facts in the environment in which the system operates; second, a “tracing” condition, according to which the system should be designed in such a way as to grant the possibility to always trace back the outcome of its operations to at least one human along the chain of design and operation. As we think that meaningful human control can be one of the central notions in ethics of robotics and AI, in the last part of the paper, we start exploring the implications of our account for the design and use of non

  10. Application of Multi-Valued Weighting Logical Functions in the Analysis of a Degree of Importance of Construction Parameters on the Example of Hydraulic Valves

    Science.gov (United States)

    Deptuła, A.

    2014-08-01

    In the optimization process, changes in the construction parameters value influence the behaviour of functions depending on time. Weighting logical coefficients for the stabilisation time are taken into consideration here, i.e., a shorter (better) stabilisation time has a more important (bigger) value of the weighting coefficient. An example of applying weighting logical functions in the analysis of a degree of importance of construction parameters of a hydraulic valve is presented in the paper

  11. Numerical solution of a logistic growth model for a population with Allee effect considering fuzzy initial values and fuzzy parameters

    Science.gov (United States)

    Amarti, Z.; Nurkholipah, N. S.; Anggriani, N.; Supriatna, A. K.

    2018-03-01

    Predicting the future of population number is among the important factors that affect the consideration in preparing a good management for the population. This has been done by various known method, one among them is by developing a mathematical model describing the growth of the population. The model usually takes form in a differential equation or a system of differential equations, depending on the complexity of the underlying properties of the population. The most widely used growth models currently are those having a sigmoid solution of time series, including the Verhulst logistic equation and the Gompertz equation. In this paper we consider the Allee effect of the Verhulst’s logistic population model. The Allee effect is a phenomenon in biology showing a high correlation between population size or density and the mean individual fitness of the population. The method used to derive the solution is the Runge-Kutta numerical scheme, since it is in general regarded as one among the good numerical scheme which is relatively easy to implement. Further exploration is done via the fuzzy theoretical approach to accommodate the impreciseness of the initial values and parameters in the model.

  12. Effect of Scanning and Reconstruction Parameters on Three Dimensional Volume and CT Value Measurement of Pulmonary Nodules: A Phantom Study

    Directory of Open Access Journals (Sweden)

    Datong SU

    2017-08-01

    Full Text Available Background and objective The computed tomography (CT follow-up of indeterminate pulmonary nodules aiming to evaluate the change of the volume and CT value is the common strategy in clinic. The CT dose needs to considered on serious CT scans in addition to the measurement accuracy. The purpose of this study is to quantify the precision of pulmonary nodule volumetric measurement and CT value measurement with various tube currents and reconstruction algorithms in a phantom study with dual-energy CT. Methods A chest phantom containing 9 artificial spherical solid nodules with known diameter (D=2.5 mm, 5 mm, 10 mm and density (-100 HU, 60 HU and 100 HU was scanned using a 64-row detector CT canner at 120 Kilovolt & various currents (10 mA, 20 mA, 50 mA, 80 mA,100 mA, 150 mA and 350 mA. Raw data were reconstructed with filtered back projection and three levels of adaptive statistical iterative reconstruction algorithm (FBP, ASIR; 30%, 50% and 80%. Automatic volumetric measurements were performed using commercially available software. The relative volume error (RVE and the absolute attenuation error (AAE between the software measures and the reference-standard were calculated. Analyses of the variance were performed to evaluate the effect of reconstruction methods, different scan parameters, nodule size and attenuation on the RPE. Results The software substantially overestimated the very small (D=2.5 mm nodule's volume [mean RVE: (100.8%±28%] and underestimated it attenuation [mean AAE: (-756±80 HU]. The mean RVEs of nodule with diameter as 5 mm and 10 mm were small [(-0.9%±1.1% vs (0.9%±1.4%], however, the mean AAEs [(-243±26 HU vs (-129±7 HU] were large. The ANOVA analysis for repeated measurements showed that different tube current and reconstruction algorithm had no significant effect on the volumetric measurements for nodules with diameter of 5 mm and 10 mm (F=5.60, P=0.10 vs F=11.13, P=0.08, but significant effects on the measurement of CT

  13. ON THE DERIVATIVE OF SMOOTH MEANINGFUL FUNCTIONS

    Directory of Open Access Journals (Sweden)

    Sanjo Zlobec

    2011-02-01

    Full Text Available The derivative of a function f in n variables at a point x* is one of the most important tools in mathematical modelling. If this object exists, it is represented by the row n-tuple f(x* = [∂f/∂xi(x*] called the gradient of f at x*, abbreviated: “the gradient”. The evaluation of f(x* is usually done in two stages, first by calculating the n partials and then their values at x = x*. In this talk we give an alternative approach. We show that one can characterize the gradient without differentiation! The idea is to fix an arbitrary row n-tuple G and answer the following question: What is a necessary and sufficient condition such that G is the gradient of a given f at a given x*? The answer is given after adjusting the quadratic envelope property introduced in [3]. We work with smooth, i.e., continuously differentiable, functions with a Lipschitz derivative on a compact convex set with a non-empty interior. Working with this class of functions is not a serious restriction. In fact, loosely speaking, “almost all” smooth meaningful functions used in modelling of real life situations are expected to have a bounded “acceleration” hence they belong to this class. In particular, the class contains all twice differentiable functions [1]. An important property of the functions from this class is that every f can be represented as the difference of some convex function and a convex quadratic function. This decomposition was used in [3] to characterize the zero derivative points. There we obtained reformulations and augmentations of some well known classic results on optimality such as Fermats extreme value theorem (known from high school and the Lagrange multiplier theorem from calculus [2, 3]. In this talk we extend the results on zero derivative points to characterize the relation G = f(x*, where G is an arbitrary n-tuple. Some special cases: If G = O, we recover the results on zero derivative points. For functions of a single

  14. Meaningful Use of a Confidential Adolescent Patient Portal.

    Science.gov (United States)

    Thompson, Lindsay A; Martinko, Thomas; Budd, Pamela; Mercado, Rebeccah; Schentrup, Anzeela M

    2016-02-01

    To design and evaluate the usage of an adolescent patient portal specifically adapted for adolescent health care needs that also satisfied institutional meaningful use guidelines regarding electronic health records. Key stakeholders at one academic health care center adopted an online portal and opted to designate a patient portal specifically for adolescents to maximize confidentiality in compliance with state privacy laws. This study analyzed aggregate electronic health record data of adolescents' (ages 12-17.9 years) uptake, usage, and functionality of this portal and compared it to parent portal usage for younger children (ages 0-11 years). Differences in means were calculated using paired t tests. The portal was used similarly between parents of young children and adolescents, with almost 1,000 enrollees in each group from September 1, 2012 to March 31, 2015. There were no gender differences in enrollment. Adolescents were less likely than parents of younger children to review appointments (73% vs. 85%), laboratory tests (67% vs. 79%), problem lists (40% vs. 78%), or allergies (45% vs. 77%, all p values adolescents sent 1,397 confidential messages. Institutional decisions for implementing meaningful use requirements can align with goals of adolescent health. Patient portals can enhance adolescent health care quality and adolescents readily use a confidential portal. Implementation of meaningful use requirements should be checked against adolescent health care needs to maximize confidentiality and promote health communication. Copyright © 2016 Society for Adolescent Health and Medicine. Published by Elsevier Inc. All rights reserved.

  15. The strong prognostic value of KELIM, a model-based parameter from CA 125 kinetics in ovarian cancer

    DEFF Research Database (Denmark)

    You, Benoit; Colomban, Olivier; Heywood, Mark

    2013-01-01

    Unexpected results were recently reported about the poor surrogacy of Gynecologic Cancer Intergroup (GCIG) defined CA-125 response in recurrent ovarian cancer (ROC) patients. Mathematical modeling may help describe CA-125 decline dynamically and discriminate prognostic kinetic parameters....

  16. End user programming with personally meaningful objects

    CSIR Research Space (South Africa)

    Smith, Andrew C

    2016-09-01

    Full Text Available (Kimchi et al., 2003). Perceptual organisation is a neuro-cognitive process that dictates how we perceive objects in physical space and how we interpret some objects as being distinct from others and yet other objects as part of a whole (Helm, 2014... called the designer-cum-user. Using this approach, the user creates a personally meaningful artefact that represents the target product. Although not confirmed, we anticipate that this approach reduces the initial cognitive load on the user when he uses...

  17. Determination of negligible concentration threshold values for water pollution assessment; Ableitung von Geringfuegigkeitsschwellen zur Beurteilung von Grundwasserverunreinigungen. T. 2. Organische Parameter

    Energy Technology Data Exchange (ETDEWEB)

    Trenck, K.T. von der [Landesanstalt fuer Umweltschutz Baden-Wuerttemberg, Karlsruhe (Germany); Roeder, R.; Slama, H. [Bayerische Landesanstalt fuer Wasserforschung (BayLWF), Muenchen (Germany); Markard, C.; Kuehl, C. [Umweltbundesamt, Berlin (Germany)

    1999-12-01

    Part I of the status report contains the derivation criteria, the reasons for the inorganic parameters chosen, and explanations of terms and abbreviations. A table is presented which contains negligible concentration threshold values for selected parameters of inorganic and organic substances. [German] Der erste Teil des Statusberichts enthaelt eine ausfuehrliche Darstellung der Ableitungskriterien sowie die Begruendung fuer die anorganischen Parameter und Erlaeuterungen zu den Abkuerzungen und Begriffen. Entsprechende Konzentrationswerte fuer die Geringfuegigkeitsschwellen einer Auswahl an Parametern enthaelt eine in der vorliegenden Arbeit aufgefuehrte Tabelle getrennt nach anorganischen und organischen Stoffen. (orig.)

  18. Whole lesion histogram analysis of meningiomas derived from ADC values. Correlation with several cellularity parameters, proliferation index KI 67, nucleic content, and membrane permeability.

    Science.gov (United States)

    Surov, Alexey; Hamerla, Gordian; Meyer, Hans Jonas; Winter, Karsten; Schob, Stefan; Fiedler, Eckhard

    2018-09-01

    To analyze several histopathological features and their possible correlations with whole lesion histogram analysis derived from ADC maps in meningioma. The retrospective study involved 36 patients with primary meningiomas. For every tumor, the following histogram analysis parameters of apparent diffusion coefficient (ADC) were calculated: ADC mean , ADC max , ADC min , ADC median , ADC mode , ADC percentiles: P10, P25, P75, P90, as well kurtosis, skewness, and entropy. All measures were performed by two radiologists. Proliferation index KI 67, minimal, maximal and mean cell count, total nucleic area, and expression of water channel aquaporin 4 (AQP4) were estimated. Spearman's correlation coefficient was used to analyze associations between investigated parameters. A perfect interobserver agreement for all ADC values (0.84-0.97) was identified. All ADC values correlated inversely with tumor cellularity with the strongest correlation between P10, P25 and mean cell count (-0.558). KI 67 correlated inversely with all ADC values except ADC min . ADC parameters did not correlate with total nucleic area. All ADC values correlated statistically significant with expression of AQP4. ADC histogram analysis is a valid method with an excellent interobserver agreement. Cellularity parameters and proliferation potential are associated with different ADC values. Membrane permeability may play a greater role for water diffusion than cell count and proliferation activity. Copyright © 2018 Elsevier Inc. All rights reserved.

  19. Engaging in Work Even When It Is Meaningless: Positive Affective Disposition and Meaningful Work Interact in Relation to Work Engagement

    Science.gov (United States)

    Steger, Michael F.; Littman-Ovadia, Hadassah; Miller, Michal; Menger, Lauren; Rothmann, Sebastiaan

    2013-01-01

    The central aim of the present study was to assess the predictive value of affective disposition and meaningful work on employee engagement. Specifically, it was proposed that meaningful work moderates the relationship between affective disposition and engagement. Questionnaires were completed by 252 white-collar employees, working in a variety of…

  20. Meaningful radiation worker training for temporary craftsmen

    International Nuclear Information System (INIS)

    Williams, S.L.

    1976-01-01

    The carefully organized Radiation Worker Training Program presented to permanently assigned personnel at a power reactor facility too often falls by the wayside when temporary craftsmen are brought in for an outage. Even though these temporary workers will frequently be assigned to outage jobs with high radiation and/or contamination exposures, their Radiation Worker Training is often squeezed into an already busy schedule, thus reducing its effectiveness. As an aid for evaluating the effectiveness of an existing Radiation Worker Training Program for temporary craftsmen or for setting up a new program, the following guides are presented and discussed in this paper: the training environment; the interest and meaningfulness of the presentation; the method or methods used for presentation of the training information; the use of demonstrations; trainee participation; and, measuring the amount and type of information retained by a trainee. Meaningful Radiation Worker Training for temporary craftsmen can pay big dividends. Craftsmen can be expected to make fewer mistakes, thus reducing radiation exposure and lessening the chance for the spread of contamination. The craftsmen will also benefit by being able to work longer and utility management will benefit by having lower outage costs

  1. MIB-1, AgNOR AND DNA DISTRIBUTION PARAMETERS AND THEIR PROGNOSTIC VALUE IN NEUROENDOCRINE TUMOURS OF THE LUNG

    Directory of Open Access Journals (Sweden)

    Uta Jütting

    2011-05-01

    Full Text Available One of the most important questions in clinical routine is to find out patients with good or worse prognosis to apply an optimal therapy scheme for each patient. In this study 58 patients with different neuroendocrine tumours of the lung were investigated. Histological sections were prepared with different stainings (MIB-1, AgNOR, Feulgen. By means of high resolution image cytometry stereological parameters were derived which are indicators for proliferation, ploidy and kinetics of the tumours. Cox regression analysis was calculated to test the significance of the parameters with regard to prognosis. The best parameter was MIB-1 which can easily be applied as a clinical standard staining and measurement.

  2. The value of arterial blood gas parameters for prediction of mortality in survivors of out-of-hospital cardiac arrest

    Directory of Open Access Journals (Sweden)

    Katharina Isabel von Auenmueller

    2017-01-01

    Full Text Available Context: Sudden cardiac death is one of the leading causes of death in Europe, and early prognostication remains challenging. There is a lack of valid parameters for the prediction of survival after cardiac arrest. Aims: This study aims to investigate if arterial blood gas parameters correlate with mortality of patients after out-of-hospital cardiac arrest. Materials and Methods: All patients who were admitted to our hospital after resuscitation following out-of-hospital cardiac arrest between January 1, 2008, and December 31, 2013, were included in this retrospective study. The patient's survival 5 days after resuscitation defined the study end-point. For the statistical analysis, the mean, standard deviation, Student's t-test, Chi-square test, and logistic regression analyses were used (level of significance P< 0.05. Results: Arterial blood gas samples were taken from 170 patients. In particular, pH < 7.0 (odds ratio [OR]: 7.20; 95% confidence interval [CI]: 3.11–16.69; P< 0.001 and lactate ≥ 5.0 mmol/L (OR: 6.79; 95% CI: 2.77–16.66; P< 0.001 showed strong and independent correlations with mortality within the first 5 days after hospital admission. Conclusion: Our study results indicate that several arterial blood gas parameters correlate with mortality of patients after out-of-hospital resuscitation. The most relevant parameters are pH and lactate because they are strongly and independently associated with mortality within the first 5 days after resuscitation. Despite this correlation, none of these parameters by oneself is strong enough to allow an early prognostication. Still, these parameters can contribute as part of a multimodal approach to assessing the patients' prognosis.

  3. The Impact of Variability of Selected Geological and Mining Parameters on the Value and Risks of Projects in the Hard Coal Mining Industry

    Science.gov (United States)

    Kopacz, Michał

    2017-09-01

    The paper attempts to assess the impact of variability of selected geological (deposit) parameters on the value and risks of projects in the hard coal mining industry. The study was based on simulated discounted cash flow analysis, while the results were verified for three existing bituminous coal seams. The Monte Carlo simulation was based on nonparametric bootstrap method, while correlations between individual deposit parameters were replicated with use of an empirical copula. The calculations take into account the uncertainty towards the parameters of empirical distributions of the deposit variables. The Net Present Value (NPV) and the Internal Rate of Return (IRR) were selected as the main measures of value and risk, respectively. The impact of volatility and correlation of deposit parameters were analyzed in two aspects, by identifying the overall effect of the correlated variability of the parameters and the indywidual impact of the correlation on the NPV and IRR. For this purpose, a differential approach, allowing determining the value of the possible errors in calculation of these measures in numerical terms, has been used. Based on the study it can be concluded that the mean value of the overall effect of the variability does not exceed 11.8% of NPV and 2.4 percentage points of IRR. Neglecting the correlations results in overestimating the NPV and the IRR by up to 4.4%, and 0.4 percentage point respectively. It should be noted, however, that the differences in NPV and IRR values can vary significantly, while their interpretation depends on the likelihood of implementation. Generalizing the obtained results, based on the average values, the maximum value of the risk premium in the given calculation conditions of the "X" deposit, and the correspondingly large datasets (greater than 2500), should not be higher than 2.4 percentage points. The impact of the analyzed geological parameters on the NPV and IRR depends primarily on their co-existence, which can be

  4. Assessment of the underlying systems involved in standing balance: the additional value of electromyography in system identification and parameter estimation

    NARCIS (Netherlands)

    Pasma, J.H.; Kordelaar, J. van; Kam, D. de; Weerdesteyn, V.G.M.; Schouten, A.C.; Kooij, H. van der

    2017-01-01

    BACKGROUND: Closed loop system identification (CLSIT) is a method to disentangle the contribution of underlying systems in standing balance. We investigated whether taking into account lower leg muscle activation in CLSIT could improve the reliability and accuracy of estimated parameters identifying

  5. Assessment of the underlying systems involved in standing balance : the additional value of electromyography in system identification and parameter estimation

    NARCIS (Netherlands)

    Pasma, J. H.; Van Kordelaar, J.; de Kam, D.; Weerdesteyn, V.; Schouten, A. C.; Van Der Kooij, H.

    2017-01-01

    Background: Closed loop system identification (CLSIT) is a method to disentangle the contribution of underlying systems in standing balance. We investigated whether taking into account lower leg muscle activation in CLSIT could improve the reliability and accuracy of estimated parameters identifying

  6. Assessment of the underlying systems involved in standing balance : The additional value of electromyography in system identification and parameter estimation

    NARCIS (Netherlands)

    Pasma, J.H.; van Kordelaar, J.; de Kam, D.; Weerdesteyn, V.; Schouten, A.C.; van der Kooij, H.

    2017-01-01

    Background: Closed loop system identification (CLSIT) is a method to disentangle the contribution of underlying systems in standing balance. We investigated whether taking into account lower leg muscle activation in CLSIT could improve the reliability and accuracy of estimated parameters

  7. Prognostic value of (18)F-FDG PET/CT volumetric parameters in recurrent epithelial ovarian cancer.

    Science.gov (United States)

    Mayoral, M; Fernandez-Martinez, A; Vidal, L; Fuster, D; Aya, F; Pavia, J; Pons, F; Lomeña, F; Paredes, P

    2016-01-01

    Metabolic tumour volume (MTV) and total lesion glycolysis (TLG) from (18)F-FDG PET/CT are emerging prognostic biomarkers in various solid neoplasms. These volumetric parameters and the SUVmax have shown to be useful criteria for disease prognostication in preoperative and post-treatment epithelial ovarian cancer (EOC) patients. The purpose of this study was to evaluate the utility of (18)F-FDG PET/CT measurements to predict survival in patients with recurrent EOC. Twenty-six patients with EOC who underwent a total of 31 (18)F-FDG PET/CT studies for suspected recurrence were retrospectively included. SUVmax and volumetric parameters whole-body MTV (wbMTV) and whole-body TLG (wbTLG) with a threshold of 40% and 50% of the SUVmax were obtained. Correlation between PET parameters and progression-free survival (PFS) and the survival analysis of prognostic factors were calculated. Serous cancer was the most common histological subtype (76.9%). The median PFS was 12.5 months (range 10.7-20.6 months). Volumetric parameters showed moderate inverse correlation with PFS but there was no significant correlation in the case of SUVmax. The correlation was stronger for first recurrences. By Kaplan-Meier analysis and log-rank test, wbMTV 40%, wbMTV 50% and wbTLG 50% correlated with PFS. However, SUVmax and wbTLG 40% were not statistically significant predictors for PFS. Volumetric parameters wbMTV and wbTLG 50% measured by (18)F-FDG PET/CT appear to be useful prognostic predictors of outcome and may provide valuable information to individualize treatment strategies in patients with recurrent EOC. Copyright © 2015 Elsevier España, S.L.U. and SEMNIM. All rights reserved.

  8. Value of quantitative MRI parameters in predicting and evaluating clinical outcome in conservatively treated patients with chronic midportion Achilles tendinopathy: A prospective study.

    Science.gov (United States)

    Tsehaie, J; Poot, D H J; Oei, E H G; Verhaar, J A N; de Vos, R J

    2017-07-01

    To evaluate whether baseline MRI parameters provide prognostic value for clinical outcome, and to study correlation between MRI parameters and clinical outcome. Observational prospective cohort study. Patients with chronic midportion Achilles tendinopathy were included and performed a 16-week eccentric calf-muscle exercise program. Outcome measurements were the validated Victorian Institute of Sports Assessment-Achilles (VISA-A) questionnaire and MRI parameters at baseline and after 24 weeks. The following MRI parameters were assessed: tendon volume (Volume), tendon maximum cross-sectional area (CSA), tendon maximum anterior-posterior diameter (AP), and signal intensity (SI). Intra-class correlation coefficients (ICCs) and minimum detectable changes (MDCs) for each parameter were established in a reliability analysis. Twenty-five patients were included and complete follow-up was achieved in 20 patients. The average VISA-A scores increased significantly with 12.3 points (27.6%). The reliability was fair-good for all MRI-parameters with ICCs>0.50. Average tendon volume and CSA decreased significantly with 0.28cm 3 (5.2%) and 4.52mm 2 (4.6%) respectively. Other MRI parameters did not change significantly. None of the baseline MRI parameters were univariately associated with VISA-A change after 24 weeks. MRI SI increase over 24 weeks was positively correlated with the VISA-A score improvement (B=0.7, R 2 =0.490, p=0.02). Tendon volume and CSA decreased significantly after 24 weeks of conservative treatment. As these differences were within the MDC limits, they could be a result of a measurement error. Furthermore, MRI parameters at baseline did not predict the change in symptoms, and therefore have no added value in providing a prognosis in daily clinical practice. Copyright © 2017 Sports Medicine Australia. Published by Elsevier Ltd. All rights reserved.

  9. Resolving model parameter values from carbon and nitrogen stock measurements in a wide range of tropical mature forests using nonlinear inversion and regression trees

    Science.gov (United States)

    Shuguang Liua; Pamela Anderson; Guoyi Zhoud; Boone Kauffman; Flint Hughes; David Schimel; Vicente Watson; Joseph. Tosi

    2008-01-01

    Objectively assessing the performance of a model and deriving model parameter values from observations are critical and challenging in landscape to regional modeling. In this paper, we applied a nonlinear inversion technique to calibrate the ecosystem model CENTURY against carbon (C) and nitrogen (N) stock measurements collected from 39 mature tropical forest sites in...

  10. Predictive value of MR imaging-dependent and non-MR imaging-dependent parameters for recurrence of laryngeal cancer after radiation therapy

    NARCIS (Netherlands)

    Castelijns, J. A.; van den Brekel, M. W.; Smit, E. M.; Tobi, H.; van Wagtendonk, F. W.; Golding, R. P.; Venema, H. W.; van Schaik, C.; Snow, G. B.

    1995-01-01

    To determine the predictive value of several clinical and radiologic parameters for recurrence of laryngeal cancer. Eighty previously untreated patients underwent magnetic resonance (MR) imaging before radiation therapy with curative intent. Tumor volume was calculated from T1-weighted MR images.

  11. The Retention of Meaningful Understanding of Meiosis and Genetics.

    Science.gov (United States)

    Cavallo, Ann Liberatore

    This study investigated the retention of meaningful understanding of the biological topics of meiosis, the Punnett square method and the relations between these two topics. This study also explored the predictive influence of students' general tendency to learn meaningfully or by rote (meaningful learning orientation), prior knowledge of meiosis,…

  12. Deep Learning for Magnetic Resonance Fingerprinting: A New Approach for Predicting Quantitative Parameter Values from Time Series.

    Science.gov (United States)

    Hoppe, Elisabeth; Körzdörfer, Gregor; Würfl, Tobias; Wetzl, Jens; Lugauer, Felix; Pfeuffer, Josef; Maier, Andreas

    2017-01-01

    The purpose of this work is to evaluate methods from deep learning for application to Magnetic Resonance Fingerprinting (MRF). MRF is a recently proposed measurement technique for generating quantitative parameter maps. In MRF a non-steady state signal is generated by a pseudo-random excitation pattern. A comparison of the measured signal in each voxel with the physical model yields quantitative parameter maps. Currently, the comparison is done by matching a dictionary of simulated signals to the acquired signals. To accelerate the computation of quantitative maps we train a Convolutional Neural Network (CNN) on simulated dictionary data. As a proof of principle we show that the neural network implicitly encodes the dictionary and can replace the matching process.

  13. [Prognostic value of chosen parameters of mechanical and bioelectrical uterine activity in prediction of threatening preterm labour].

    Science.gov (United States)

    Zietek, Jerzy; Sikora, Jerzy; Horoba, Krzysztof; Matonia, Adam; Jezewski, Janusz; Magnucki, Jacek; Kobielska, Lucyna

    2009-03-01

    To record and analyse bioelectrical activity of the uterine muscle in the course of physiological pregnancy, labour and threatening premature labour; to define which parameters from the analysis of both electrohysterogram and mechanical activity signal allow us to predict threatening premature labour. Material comprised 62 pregnant women: Group I--27 patients in their first physiological pregnancy, Group II--21 patients in their first pregnancy with symptoms of threatening premature labour, and Group III--14 patients in the first labour period. The on-line analysis of the mechanical (TOCO) and electrical (EHG) contraction activity relied on determination of quantitative parameters of detected uterine contractions. The obtained statistical results demonstrated a possibility to differentiate between Group I and II through the amplitude and contraction area for EHG signal, and only the contraction amplitude for TOCO signal. Additionally, significant differentiating parameters for electrohysterogram are: contraction power and its median frequency. Analyzing Group I and III, significant differences were noted for contraction amplitude and area obtained both from EHG and TOCO signals. Similarly, the contraction power (from EHG) enables us to assign the contractions either to records from Group I or to labour type. There was no significant difference noted between Group II and III. Identification of pregnant women at risk of premature labour should lead to their inclusion in rigorous perinatal surveillance. This requires novel, more sensitive methods that are able to detect early symptoms of the uterine contraction activity increase. Electrohysterography provides complete information on principles of bioelectrical uterine activity. Quantitative parameters of EHG analysis enable the detection of records (contractions) with the symptoms of premature uterine contraction activity.

  14. An integrative approach to inferring biologically meaningful gene modules

    Directory of Open Access Journals (Sweden)

    Wang Kai

    2011-07-01

    Full Text Available Abstract Background The ability to construct biologically meaningful gene networks and modules is critical for contemporary systems biology. Though recent studies have demonstrated the power of using gene modules to shed light on the functioning of complex biological systems, most modules in these networks have shown little association with meaningful biological function. We have devised a method which directly incorporates gene ontology (GO annotation in construction of gene modules in order to gain better functional association. Results We have devised a method, Semantic Similarity-Integrated approach for Modularization (SSIM that integrates various gene-gene pairwise similarity values, including information obtained from gene expression, protein-protein interactions and GO annotations, in the construction of modules using affinity propagation clustering. We demonstrated the performance of the proposed method using data from two complex biological responses: 1. the osmotic shock response in Saccharomyces cerevisiae, and 2. the prion-induced pathogenic mouse model. In comparison with two previously reported algorithms, modules identified by SSIM showed significantly stronger association with biological functions. Conclusions The incorporation of semantic similarity based on GO annotation with gene expression and protein-protein interaction data can greatly enhance the functional relevance of inferred gene modules. In addition, the SSIM approach can also reveal the hierarchical structure of gene modules to gain a broader functional view of the biological system. Hence, the proposed method can facilitate comprehensive and in-depth analysis of high throughput experimental data at the gene network level.

  15. Towards a mathematical theory of meaningful communication

    Science.gov (United States)

    Corominas-Murtra, Bernat; Fortuny, Jordi; Solé, Ricard V.

    2014-04-01

    Meaning has been left outside most theoretical approaches to information in biology. Functional responses based on an appropriate interpretation of signals have been replaced by a probabilistic description of correlations between emitted and received symbols. This assumption leads to potential paradoxes, such as the presence of a maximum information associated to a channel that creates completely wrong interpretations of the signals. Game-theoretic models of language evolution and other studies considering embodied communicating agents show that the correct (meaningful) match resulting from agent-agent exchanges is always achieved and natural systems obviously solve the problem correctly. Inspired by the concept of duality of the communicative sign stated by the swiss linguist Ferdinand de Saussure, here we present a complete description of the minimal system necessary to measure the amount of information that is consistently decoded. Several consequences of our developments are investigated, such as the uselessness of a certain amount of information properly transmitted for communication among autonomous agents.

  16. The challenge of a meaningful job

    DEFF Research Database (Denmark)

    Jepsen, Ingrid

    and the feeling of doing high quality care generate job satisfaction. The obligation and pressure to perform well and the disadvantages on the midwives’ private lives is counterbalanced by the feeling of doing a meaningful and important job. Working in caseload midwifery creates a feeling of working in a self....... The methodology was inspired by ethnography, and applied methods were field observations followed by interviews. Participants: Thirteen out of eighteen midwives working in caseloads were observed during one or two days in the antenatal clinic and interviewed at a later occasion. Findings: The recognition......-governing model within the public hospital, without losing the technological benefits of a modern birth unit. For pregnant women with a challenging personality or attitude towards others, Caseload midwifery may provide an extra opportunity to feel recognized and respected. Key conclusions: Caseload midwifery...

  17. Creating Visual Design and Meaningful Audience Experiences

    DEFF Research Database (Denmark)

    Steijn, Arthur; Ion Wille, Jakob

    2014-01-01

    The main purpose of the EU Interreg funded Classical Composition Music and Experience Design project, was to rethink audience experiences and develop knowledge of applied technologies connected to classical music and live concerts. The project and its main objectives was motivated by at least thee...... conditions. The most important being 1) the development in new technology creating new expectations in audiences attending cultural events, including classical concerts, 2) resent decline in audiences attending classical music and 3) a will to strengthen relations between cultural institutions, creative...... businesses and educational institutions in the Øresund region (including the city and surroundings of Malmø and Copenhagen). Therefore the project Classical Composition Music and Experience Design focused on developing new and meaningful audience experiences where live classical music meets new digital...

  18. Meaningful Academic Work as Praxis in Emergence

    Directory of Open Access Journals (Sweden)

    Keijo Räsänen

    2008-01-01

    Full Text Available The managerial form of university governance has changed the conditions of academic work in many countries. While some academics consider this a welcome development, others experience it as a threat to their autonomy and to the meaningfulness of their work. This essay suggests a stance in response to the current conditions that should serve especially the latter group of academics. The claim is that by approaching academic work as a potential praxis in emergence, it is possible to appreciate local, autonomous activity in renewing academic work. Even if such efforts remain difficult, dispersed in space, discontinuous in time, and incomplete, they may provide a sense of direction and keep up hope. The conception of praxis is a way of articulating the mission of such efforts; simultaneously, it is also a way of defining an epistemic object for research on academic work.

  19. Neurologic dysfunction in patients with rheumatoid arthritis of the cervical spine. Predictive value of clinical, radiographic and MR imaging parameters

    International Nuclear Information System (INIS)

    Reijnierse, M.; Kroon, H.M.; Holscher, H.C.; Bloem, J.L.; Dijkmans, B.A.C.; Breedveld, F.C.; Hansen, B.; Pope, T.L.

    2001-01-01

    The aim of this study was to evaluate if subjective symptoms, radiographic and especially MR parameters of cervical spine involvement, can predict neurologic dysfunction in patients with severe rheumatoid arthritis (RA). Sequential radiographs, MR imaging, and neurologic examination were performed yearly in 46 consecutive RA patients with symptoms indicative of cervical spine involvement. Radiographic parameters were erosions of the dens or intervertebral joints, disc-space narrowing, horizontal and vertical atlantoaxial subluxation, subluxations below C2, and the diameter of the spinal canal. The MR features evaluated were presence of dens and atlas erosion, brainstem compression, subarachnoid space encroachment, pannus around the dens, abnormal fat body caudal to the clivus, cervicomedullary angle, and distance of the dens to the line of McRae. Muscle weakness was associated with a tenfold increased risk of neurologic dysfunction. Radiographic parameters were not associated. On MR images atlas erosion and a decreased distance of the dens to the line of McRae showed a fivefold increased risk of neurologic dysfunction. Subarachnoid space encroachment was associated with a 12-fold increased risk. Rheumatoid arthritis patients with muscle weakness and subarachnoid space encroachment of the entire cervical spine have a highly increased risk of developing neurologic dysfunction. (orig.)

  20. About increasing informativity of diagnostic system of asynchronous electric motor by extracting additional information from values of consumed current parameter

    Science.gov (United States)

    Zhukovskiy, Y.; Korolev, N.; Koteleva, N.

    2018-05-01

    This article is devoted to expanding the possibilities of assessing the technical state of the current consumption of asynchronous electric drives, as well as increasing the information capacity of diagnostic methods, in conditions of limited access to equipment and incompleteness of information. The method of spectral analysis of the electric drive current can be supplemented by an analysis of the components of the current of the Park's vector. The research of the hodograph evolution in the moment of appearance and development of defects was carried out using the example of current asymmetry in the phases of an induction motor. The result of the study is the new diagnostic parameters of the asynchronous electric drive. During the research, it was proved that the proposed diagnostic parameters allow determining the type and level of the defect. At the same time, there is no need to stop the equipment and taky it out of service for repair. Modern digital control and monitoring systems can use the proposed parameters based on the stator current of an electrical machine to improve the accuracy and reliability of obtaining diagnostic patterns and predicting their changes in order to improve the equipment maintenance systems. This approach can also be used in systems and objects where there are significant parasitic vibrations and unsteady loads. The extraction of useful information can be carried out in electric drive systems in the structure of which there is a power electric converter.

  1. Vibro-Impact Energy Analysis of a Geared System with Piecewise-Type Nonlinearities Using Various Parameter Values

    Directory of Open Access Journals (Sweden)

    Jong-Yun Yoon

    2015-08-01

    Full Text Available Torsional systems with gear pairs such as the gearbox of wind turbines or vehicle driveline systems inherently show impact phenomena due to clearance-type nonlinearities when the system experiences sinusoidal excitation. This research investigates the vibro-impact energy of unloaded gears in geared systems using the harmonic balance method (HBM in both the frequency and time domains. To achieve accurate simulations, nonlinear models with piecewise and clearance-type nonlinearities and drag torques are defined and implemented in the HBM. Next, the nonlinear frequency responses are examined by focusing on the resonance areas where the impact phenomena occur, along with variations in key parameters such as clutch stiffness, drag torque, and inertias of the flywheel and the unloaded gear. Finally, the effects of the parameters on the vibro-impacts at a specific excitation frequency are explained using bifurcation diagrams. The results are correlated with prior research by defining the gear rattle criteria with key parameters. This article suggests a method to simulate the impact phenomena in torsional systems using the HBM and successfully assesses vibro-impact energy using bifurcation diagrams.

  2. Neurologic dysfunction in patients with rheumatoid arthritis of the cervical spine. Predictive value of clinical, radiographic and MR imaging parameters

    Energy Technology Data Exchange (ETDEWEB)

    Reijnierse, M.; Kroon, H.M.; Holscher, H.C.; Bloem, J.L. [Dept. of Radiology, University Hospital Leiden (Netherlands); Dijkmans, B.A.C.; Breedveld, F.C. [Dept. of Rheumatology, University Hospital Leiden (Netherlands); Hansen, B. [Dept. of Medical Statistics, University Hospital Leiden (Netherlands); Pope, T.L. [Dept. of Diagnostic Radiology, Univ. of South Carolina (United States)

    2001-03-01

    The aim of this study was to evaluate if subjective symptoms, radiographic and especially MR parameters of cervical spine involvement, can predict neurologic dysfunction in patients with severe rheumatoid arthritis (RA). Sequential radiographs, MR imaging, and neurologic examination were performed yearly in 46 consecutive RA patients with symptoms indicative of cervical spine involvement. Radiographic parameters were erosions of the dens or intervertebral joints, disc-space narrowing, horizontal and vertical atlantoaxial subluxation, subluxations below C2, and the diameter of the spinal canal. The MR features evaluated were presence of dens and atlas erosion, brainstem compression, subarachnoid space encroachment, pannus around the dens, abnormal fat body caudal to the clivus, cervicomedullary angle, and distance of the dens to the line of McRae. Muscle weakness was associated with a tenfold increased risk of neurologic dysfunction. Radiographic parameters were not associated. On MR images atlas erosion and a decreased distance of the dens to the line of McRae showed a fivefold increased risk of neurologic dysfunction. Subarachnoid space encroachment was associated with a 12-fold increased risk. Rheumatoid arthritis patients with muscle weakness and subarachnoid space encroachment of the entire cervical spine have a highly increased risk of developing neurologic dysfunction. (orig.)

  3. Estimating the impact of somatic cell count on the value of milk utilising parameters obtained from the published literature.

    Science.gov (United States)

    Geary, Una; Lopez-Villalobos, Nicolas; O'Brien, Bernadette; Garrick, Dorian J; Shalloo, Laurence

    2014-05-01

    The impact of mastitis on milk value per litre independent of the effect of mastitis on milk volume, was quantified for Ireland using a meta-analysis and a processing sector model. Changes in raw milk composition, cheese processing and composition associated with increased bulk milk somatic cell count (BMSCC) were incorporated into the model. Processing costs and market values were representative of current industry values. It was assumed that as BMSCC increased (i) milk fat and milk protein increased and milk lactose decreased, (ii) fat and protein recoveries decreased, (iii) cheese protein decreased and cheese moisture increased. Five BMSCC categories were examined from ⩽100 000 to >400 000 cells/ml. The analysis showed that as BMSCC increased the production quantities reduced. An increase in BMSCC from 100 000 to >400 000 cells/ml saw a reduction in net revenue of 3·2% per annum (€51·3 million) which corresponded to a reduction in the value of raw milk of €0·0096 cents/l.

  4. Optimization of parameter values for complex pulse sequences by simulated annealing: application to 3D MP-RAGE imaging of the brain.

    Science.gov (United States)

    Epstein, F H; Mugler, J P; Brookeman, J R

    1994-02-01

    A number of pulse sequence techniques, including magnetization-prepared gradient echo (MP-GRE), segmented GRE, and hybrid RARE, employ a relatively large number of variable pulse sequence parameters and acquire the image data during a transient signal evolution. These sequences have recently been proposed and/or used for clinical applications in the brain, spine, liver, and coronary arteries. Thus, the need for a method of deriving optimal pulse sequence parameter values for this class of sequences now exists. Due to the complexity of these sequences, conventional optimization approaches, such as applying differential calculus to signal difference equations, are inadequate. We have developed a general framework for adapting the simulated annealing algorithm to pulse sequence parameter value optimization, and applied this framework to the specific case of optimizing the white matter-gray matter signal difference for a T1-weighted variable flip angle 3D MP-RAGE sequence. Using our algorithm, the values of 35 sequence parameters, including the magnetization-preparation RF pulse flip angle and delay time, 32 flip angles in the variable flip angle gradient-echo acquisition sequence, and the magnetization recovery time, were derived. Optimized 3D MP-RAGE achieved up to a 130% increase in white matter-gray matter signal difference compared with optimized 3D RF-spoiled FLASH with the same total acquisition time. The simulated annealing approach was effective at deriving optimal parameter values for a specific 3D MP-RAGE imaging objective, and may be useful for other imaging objectives and sequences in this general class.

  5. Protestant ethic: Contributing towards a meaningful workplace

    African Journals Online (AJOL)

    2013-04-12

    Apr 12, 2013 ... the outset having any particular theory in view, though it is motivated by the feeling that a theory ... structure of this ethic or value system as 'Protestant'? ... work values and incentive preference (Basini & Buckley 1996–1997).

  6. Perspective: The missing link in academic career planning and development: pursuit of meaningful and aligned work.

    Science.gov (United States)

    Lieff, Susan J

    2009-10-01

    Retention of faculty in academic medicine is a growing challenge. It has been suggested that inattention to the humanistic values of the faculty is contributing to this problem. Professional development should consider faculty members' search for meaning, purpose, and professional fulfillment and should support the development of an ability to reflect on these issues. Ensuring the alignment of academic physicians' inner direction with their outer context is critical to professional fulfillment and effectiveness. Personal reflection on the synergy of one's strengths, passions, and values can help faculty members define meaningful work so as to enable clearer career decision making. The premise of this article is that an awareness of and the pursuit of meaningful work and its alignment with the academic context are important considerations in the professional fulfillment and retention of academic faculty. A conceptual framework for understanding meaningful work and alignment and ways in which that framework can be applied and taught in development programs are presented and discussed.

  7. Prognostic value of exercise echocardiography: validation of a new risk index combining echocardiographic, treadmill, and exercise electrocardiographic parameters.

    Science.gov (United States)

    Mazur, Wojciech; Rivera, Jose M; Khoury, Alexander F; Basu, Abhijeet G; Perez-Verdia, Alejandro; Marks, Gary F; Chang, Su Min; Olmos, Leopoldo; Quiñones, Miguel A; Zoghbi, William A

    2003-04-01

    Exercise (Ex) echocardiography has been shown to have significant prognostic power, independent of other known predictors of risk from an Ex stress test. The purpose of this study was to evaluate a risk index, incorporating echocardiographic and conventional Ex variables, for a more comprehensive risk stratification and identification of a very low-risk group. Two consecutive, mutually exclusive populations referred for treadmill Ex echocardiography with the Bruce protocol were investigated: hypothesis-generating (388 patients; 268 males; age 55 +/- 13 years) and hypothesis-testing (105 patients; 61 males age: 54 +/- 14 years).Cardiac events included cardiac death, myocardial infarction, late revascularization (>90 days), hospital admission for unstable angina, and admission for heart failure. Mean follow-up in the hypothesis-generating population was 3.1 years. There were 38 cardiac events. Independent predictors of events by multivariate analysis were: Ex wall motion score index (odds ratio [OR] = 2.77/Unit; P or = 1 mm (OR = 2.84; P =.002); and treadmill time (OR = 0.87/min; P =.037). A risk index was generated on the basis of the multivariate Cox regression model as: risk index = 1.02 (Ex wall motion score index) + 1.04 (S-T change) - 0.14 (treadmill time). The validity of this index was tested in the hypothesis-testing population. Event rates at 3 years were lowest (0%) in the lower quartile of risk index (-1.22 to -0.47), highest (29.6%) in the upper quartile (+0.66 to +2.02), and intermediate (19.2% to 15.3%) in the intermediate quartiles. The OR of the risk index for predicting cardiac events was 2.94/Unit ([95% confidence interval: 1.4 to 6.2]; P =.0043). Echocardiographic and Ex parameters are independent powerful predictors of cardiac events after treadmill stress testing. A risk index can be derived with these parameters for a more comprehensive risk stratification with Ex echocardiography.

  8. Motivational reading on education, meaningful reading realisation

    Directory of Open Access Journals (Sweden)

    Adriana Qafa

    2017-07-01

    Full Text Available In this study I will present some ideas on today’s educational practice for motivation, the realization of the meaningful reading. There is a special place for the methodical ranking of the reading process, starting in school. Main requests of this reading, consist of the deep meaning of the subject, exploration of the idea, and other elements of the subject, implementation of the technique’s rules of the expressive reading, such as breathing, voice, diction, intonation, spelling, stoppages, logical emphasizes, emotional expressions, temper, timber, gesticulations, and mimic. There is also highlighted the fact that the used method comes from the pupils’ results and depends on the capability and level of the teacher, from the programming’s scale, the tools that are put into disposition, the age and the level of the pupils, and from the environment that the teacher creates during courses. At the end there are some practical guidelines for the realization of the expressive reading in the literature subject.

  9. Prognostic value of pre-treatment DCE-MRI parameters in predicting disease free and overall survival for breast cancer patients undergoing neoadjuvant chemotherapy

    International Nuclear Information System (INIS)

    Pickles, Martin D.; Manton, David J.; Lowry, Martin; Turnbull, Lindsay W.

    2009-01-01

    The purpose of this study was to investigate whether dynamic contrast enhanced MRI (DCE-MRI) data, both pharmacokinetic and empirical, can predict, prior to neoadjuvant chemotherapy, which patients are likely to have a shorter disease free survival (DFS) and overall survival (OS) interval following surgery. Traditional prognostic parameters were also included in the survival analysis. Consequently, a comparison of the prognostic value could be made between all the parameters studied. MR examinations were conducted on a 1.5 T system in 68 patients prior to the initiation of neoadjuvant chemotherapy. DCE-MRI consisted of a fast spoiled gradient echo sequence acquired over 35 phases with a mean temporal resolution of 11.3 s. Both pharmacokinetic and empirical parameters were derived from the DCE-MRI data. Kaplan-Meier survival plots were generated for each parameter and group comparisons were made utilising logrank tests. The results from the 54 patients entered into the univariate survival analysis demonstrated that traditional prognostic parameters (tumour grade, hormonal status and size), empirical parameters (maximum enhancement index, enhancement index at 30 s, area under the curve and initial slope) and adjuvant therapies demonstrated significant differences in survival intervals. Further multivariate Cox regression survival analysis revealed that empirical enhancement parameters contributed the greatest prediction of both DFS and OS in the resulting models. In conclusion, this study has demonstrated that in patients who exhibit high levels of perfusion and vessel permeability pre-treatment, evidenced by elevated empirical DCE-MRI parameters, a significantly lower disease free survival and overall survival can be expected.

  10. Prognostic value of pre-treatment DCE-MRI parameters in predicting disease free and overall survival for breast cancer patients undergoing neoadjuvant chemotherapy

    Energy Technology Data Exchange (ETDEWEB)

    Pickles, Martin D. [Centre for Magnetic Resonance Investigations, Division of Cancer, Postgraduate Medical School, University of Hull, Hull Royal Infirmary, Anlaby Road, Hull, HU3 2JZ (United Kingdom)], E-mail: m.pickles@hull.ac.uk; Manton, David J. [Centre for Magnetic Resonance Investigations, Division of Cancer, Postgraduate Medical School, University of Hull, Hull Royal Infirmary, Anlaby Road, Hull, HU3 2JZ (United Kingdom)], E-mail: d.j.manton@hull.ac.uk; Lowry, Martin [Centre for Magnetic Resonance Investigations, Division of Cancer, Postgraduate Medical School, University of Hull, Hull Royal Infirmary, Anlaby Road, Hull, HU3 2JZ (United Kingdom)], E-mail: m.lowry@hull.ac.uk; Turnbull, Lindsay W. [Centre for Magnetic Resonance Investigations, Division of Cancer, Postgraduate Medical School, University of Hull, Hull Royal Infirmary, Anlaby Road, Hull, HU3 2JZ (United Kingdom)], E-mail: l.w.turnbull@hull.ac.uk

    2009-09-15

    The purpose of this study was to investigate whether dynamic contrast enhanced MRI (DCE-MRI) data, both pharmacokinetic and empirical, can predict, prior to neoadjuvant chemotherapy, which patients are likely to have a shorter disease free survival (DFS) and overall survival (OS) interval following surgery. Traditional prognostic parameters were also included in the survival analysis. Consequently, a comparison of the prognostic value could be made between all the parameters studied. MR examinations were conducted on a 1.5 T system in 68 patients prior to the initiation of neoadjuvant chemotherapy. DCE-MRI consisted of a fast spoiled gradient echo sequence acquired over 35 phases with a mean temporal resolution of 11.3 s. Both pharmacokinetic and empirical parameters were derived from the DCE-MRI data. Kaplan-Meier survival plots were generated for each parameter and group comparisons were made utilising logrank tests. The results from the 54 patients entered into the univariate survival analysis demonstrated that traditional prognostic parameters (tumour grade, hormonal status and size), empirical parameters (maximum enhancement index, enhancement index at 30 s, area under the curve and initial slope) and adjuvant therapies demonstrated significant differences in survival intervals. Further multivariate Cox regression survival analysis revealed that empirical enhancement parameters contributed the greatest prediction of both DFS and OS in the resulting models. In conclusion, this study has demonstrated that in patients who exhibit high levels of perfusion and vessel permeability pre-treatment, evidenced by elevated empirical DCE-MRI parameters, a significantly lower disease free survival and overall survival can be expected.

  11. Can we constrain the maximum value for the spin parameter of the super-massive objects in galactic nuclei without knowing their actual nature?

    International Nuclear Information System (INIS)

    Bambi, Cosimo

    2011-01-01

    In 4-dimensional General Relativity, black holes are described by the Kerr solution and are subject to the bound |a * |≤1, where a * is the black hole spin parameter. If current black hole candidates are not the black holes predicted in General Relativity, this bound does not hold and a * might exceed 1. In this Letter, I relax the Kerr black hole hypothesis and I find that the value of the spin parameter of the super-massive black hole candidates in galactic nuclei cannot be higher than about 1.2. A higher spin parameter would not be consistent with a radiative efficiency η>0.15, as observed at least for the most luminous AGN. While a rigorous proof is lacking, I conjecture that the bound |a * |≤1.2 is independent of the exact nature of these objects.

  12. Predictive value of different conventional and non-conventional MRI-parameters for specific domains of cognitive function in multiple sclerosis

    Directory of Open Access Journals (Sweden)

    Daniela Pinter

    2015-01-01

    Conclusions: The predictive value of distinct MRI-parameters differs for specific domains of cognitive function, with a greater impact of cortical volume, focal and diffuse white matter abnormalities on overall cognitive function, an additional role of basal ganglia iron deposition on cognitive efficiency, and thalamic and hippocampal volume on memory function. This suggests the usefulness of using multiparametric MRI to assess (microstructural correlates of different cognitive constructs.

  13. Physical parameters and performance values in starters and non-starters volleyball players: A brief research note

    Directory of Open Access Journals (Sweden)

    M.C. Marques

    2009-09-01

    Full Text Available The aim of this paper was to investigate the anthropometric and strength characteristics of elite male volleyball athletes and determines if differences exist in these characteristics between starters (S and non-starters players (NS. A group of 22 professional male team volleyball players participated in the study and the players were categorized as S (n= 13 and NS (n= 9. Anthropometric characteristics, countermovement jump, overhead medicine ball throwing and maximal dynamic strength were evaluated in all the subjects. Significant diferences in age, hight and weight were noticed between S and NS. There were no significant differences between the two groups in strength and power values, except for squat performance, where S were significant strong than NS. These findings provide normative data for elite male volleyball players competing in specific playing status. From a practical perspective, sport scientists and conditioning professionals should take specicif lower body strength characteristics of volleyball players into account when designing individualized training stauts specific training programmes.

  14. Physical parameters and performance values in starters and non-starters volleyball players: A brief research note

    Directory of Open Access Journals (Sweden)

    M.C. Marques

    2009-01-01

    Full Text Available The aim of this paper was to investigate the anthropometric and strength characteristics of elite male volleyball athletes and determines if differences exist in these characteristics between starters (S and non-starters players (NS. A group of 22 professional male team volleyball players participated in the study and the players were categorized as S (n= 13 and NS (n= 9. Anthropometric characteristics, countermovement jump, overhead medicine ball throwing and maximal dynamic strength were evaluated in all the subjects. Significant diferences in age, hight and weight were noticed between S and NS. There were no significant differences between the two groups in strength and power values, except for squat performance, where S were significant strong than NS. These findings provide normative data for elite male volleyball players competing in specific playing status. From a practical perspective, sport scientists and conditioning professionals should take specicif lower body strength characteristics of volleyball players into account when designing individualized training stauts specific training programmes.

  15. Physically meaningful and not so meaningful symmetries in Chern-Simons theory

    International Nuclear Information System (INIS)

    Giavarini, G.

    1993-01-01

    We explicitly show that the Landau gauge supersymmetry of Chern-Simons theory does not have any physical significance. In fact, the difference between an effective action both BRS invariant and Landau supersymmetric and an effective action only BRS invariant is a finite field redefinition. Having established this, we use a BRS invariant regulator that defines CS theory as the large mass limit of topologically massive Yang-Mills theory to discuss the shift k → k + c v of the bare Chern-Simons parameter k in connection with the Landau supersymmetry. Finally, to convince ourselves that the shift above is not an accident of our regularization method, we comment on the fact that all BRS invariant regulators used as yet yield the same value for the shift. (orig.)

  16. Diffusion-weighted imaging of breast lesions: Region-of-interest placement and different ADC parameters influence apparent diffusion coefficient values

    Energy Technology Data Exchange (ETDEWEB)

    Bickel, Hubert; Pinker, Katja; Polanec, Stephan; Magometschnigg, Heinrich; Wengert, Georg; Spick, Claudio; Helbich, Thomas H.; Baltzer, Pascal [Medical University Vienna, Division of Molecular and Gender Imaging, Department of Biomedical Imaging and Image-Guided Therapy, Vienna (Austria); Bogner, Wolfgang [Medical University Vienna - MR Center of Excellence, Department of Biomedical Imaging and Image-Guided Therapy, Vienna (Austria); Bago-Horvath, Zsuzsanna [Medical University Vienna, Department of Pathology, Vienna (Austria)

    2017-05-15

    To investigate the influence of region-of-interest (ROI) placement and different apparent diffusion coefficient (ADC) parameters on ADC values, diagnostic performance, reproducibility and measurement time in breast tumours. In this IRB-approved, retrospective study, 149 histopathologically proven breast tumours (109 malignant, 40 benign) in 147 women (mean age 53.2) were investigated. Three radiologists independently measured minimum, mean and maximum ADC, each using three ROI placement approaches:1 - small 2D-ROI, 2 - large 2D-ROI and 3 - 3D-ROI covering the whole lesion. One reader performed all measurements twice. Median ADC values, diagnostic performance, reproducibility, and measurement time were calculated and compared between all combinations of ROI placement approaches and ADC parameters. Median ADC values differed significantly between the ROI placement approaches (p <.001). Minimum ADC showed the best diagnostic performance (AUC.928-.956), followed by mean ADC obtained from 2D ROIs (.926-.94). Minimum and mean ADC showed high intra- (ICC.85-.94) and inter-reader reproducibility (ICC.74-.94). Median measurement time was significantly shorter for the 2D ROIs (p <.001). ROI placement significantly influences ADC values measured in breast tumours. Minimum and mean ADC acquired from 2D-ROIs are useful for the differentiation of benign and malignant breast lesions, and are highly reproducible, with rapid measurement. (orig.)

  17. Prognostic value of 18F-FDG PET image-based parameters in oesophageal cancer and impact of tumour delineation methodology

    International Nuclear Information System (INIS)

    Hatt, Mathieu; Visvikis, Dimitris; Tixier, Florent; Albarghach, Nidal M.; Pradier, Olivier; Cheze-le Rest, Catherine

    2011-01-01

    18 F-fluorodeoxyglucose (FDG) positron emission tomography (PET) image-derived parameters, such as standardized uptake value (SUV), functional tumour length (TL) and tumour volume (TV) or total lesion glycolysis (TLG), may be useful for determining prognosis in patients with oesophageal carcinoma. The objectives of this work were to investigate the prognostic value of these indices in oesophageal cancer patients undergoing combined chemoradiotherapy treatment and the impact of TV delineation strategies. A total of 45 patients were retrospectively analysed. Tumours were delineated on pretreatment 18 F-FDG scans using adaptive threshold and automatic (fuzzy locally adaptive Bayesian, FLAB) methodologies. The maximum standardized uptake value (SUV max ), SUV peak , SUV mean , TL, TV and TLG were computed. The prognostic value of each parameter for overall survival was investigated using Kaplan-Meier and Cox regression models for univariate and multivariate analyses, respectively. Large differences were observed between methodologies (from -140 to +50% for TV). SUV measurements were not significant prognostic factors for overall survival, whereas TV, TL and TLG were, irrespective of the segmentation strategy. After multivariate analysis including standard tumour staging, only TV (p < 0.002) and TL (p = 0.042) determined using FLAB were independent prognostic factors. Whereas no SUV measurement was a significant prognostic factor, TV, TL and TLG were significant prognostic factors for overall survival, irrespective of the delineation methodology. Only functional TV and TL derived using FLAB were independent prognostic factors, highlighting the need for accurate and robust PET tumour delineation tools for oncology applications. (orig.)

  18. A meaningful MESS (Medical Education Scholarship Support

    Directory of Open Access Journals (Sweden)

    Shari A. Whicker

    2016-07-01

    Full Text Available Background: Graduate medical education faculty bear the responsibility of demonstrating active research and scholarship; however, faculty who choose education-focused careers may face unique obstacles related to the lack of promotion tracks, funding, career options, and research opportunities. Our objective was to address education research and scholarship barriers by providing a collaborative peer-mentoring environment and improve the production of research and scholarly outputs. Methods: We describe a Medical Education Scholarship Support (MESS group created in 2013. MESS is an interprofessional, multidisciplinary peer-mentoring education research community that now spans multiple institutions. This group meets monthly to address education research and scholarship challenges. Through this process, we develop new knowledge, research, and scholarly products, in addition to meaningful collaborations. Results: MESS originated with eight founding members, all of whom still actively participate. MESS has proven to be a sustainable unfunded local community of practice, encouraging faculty to pursue health professions education (HPE careers and fostering scholarship. We have met our original objectives that involved maintaining 100% participant retention; developing increased knowledge in at least seven content areas; and contributing to the development of 13 peer-reviewed publications, eight professional presentations, one Masters of Education project, and one educational curriculum. Discussion: The number of individuals engaged in HPE research continues to rise. The MESS model could be adapted for use at other institutions, thereby reducing barriers HPE researchers face, providing an effective framework for trainees interested in education-focused careers, and having a broader impact on the education research landscape.

  19. Identifying meaningful activities among elderly people with demenitia: the developing process of an observation taxonomy

    DEFF Research Database (Denmark)

    Andresen, Mette

    2014-01-01

    , values and beliefs in the center formed the base in the development of the tool. Aim: To develop an observational tool which can identify meaningful activities among elderly demented nursing home residents and thereby provide staff with more knowledge and possibilities for inviting and engaging residents...

  20. Modeling sugarcane yield with a process-based model from site to continental scale: uncertainties arising from model structure and parameter values

    Science.gov (United States)

    Valade, A.; Ciais, P.; Vuichard, N.; Viovy, N.; Caubel, A.; Huth, N.; Marin, F.; Martiné, J.-F.

    2014-06-01

    Agro-land surface models (agro-LSM) have been developed from the integration of specific crop processes into large-scale generic land surface models that allow calculating the spatial distribution and variability of energy, water and carbon fluxes within the soil-vegetation-atmosphere continuum. When developing agro-LSM models, particular attention must be given to the effects of crop phenology and management on the turbulent fluxes exchanged with the atmosphere, and the underlying water and carbon pools. A part of the uncertainty of agro-LSM models is related to their usually large number of parameters. In this study, we quantify the parameter-values uncertainty in the simulation of sugarcane biomass production with the agro-LSM ORCHIDEE-STICS, using a multi-regional approach with data from sites in Australia, La Réunion and Brazil. In ORCHIDEE-STICS, two models are chained: STICS, an agronomy model that calculates phenology and management, and ORCHIDEE, a land surface model that calculates biomass and other ecosystem variables forced by STICS phenology. First, the parameters that dominate the uncertainty of simulated biomass at harvest date are determined through a screening of 67 different parameters of both STICS and ORCHIDEE on a multi-site basis. Secondly, the uncertainty of harvested biomass attributable to those most sensitive parameters is quantified and specifically attributed to either STICS (phenology, management) or to ORCHIDEE (other ecosystem variables including biomass) through distinct Monte Carlo runs. The uncertainty on parameter values is constrained using observations by calibrating the model independently at seven sites. In a third step, a sensitivity analysis is carried out by varying the most sensitive parameters to investigate their effects at continental scale. A Monte Carlo sampling method associated with the calculation of partial ranked correlation coefficients is used to quantify the sensitivity of harvested biomass to input

  1. Meaningful learning: The essential factor for conceptual change in limited or inappropriate propositional hierarchies leading to empowerment of learners

    Science.gov (United States)

    Novak, Joseph D.

    2002-07-01

    The construction and reconstruction of meanings by learners requires that they actively seek to integrate new knowledge with knowledge already in their cognitive structure. Ausubel's assimilation theory of cognitive learning has been shown to be effective in guiding research and instructional design to facilitate meaningful learning (Ausubel, The psychology of meaningful verbal learning, New York: Grune and Stratton, 1963; Educational psychology: A cognitive view, New York: Holt, Rinehart and Winston, 1968; The acquisition and retention of knowledge, Dordrecht: Kluwer, 2000). Gowin's Vee heuristic has been employed effectively to aid teachers and students in understanding the constructed nature of knowledge (Gowin, Educating, Ithaca, NY: Cornell University Press, 1981). Situated learning occurs when learning is by rote or at a lower level of meaningful learning. Concept mapping has been used effectively to aid meaningful learning with resulting modification of student's knowledge structures. When these knowledge structures are limited or faulty in some way, they may be referred to as Limited or Inappropriate Propositional Hierarchies (LIPH's). Conceptual change, or more accurately conceptual reconstrution, requires meaningful learning to modify LIPH's. Collaborative group learning facilitates meaningful learning and new knowledge construction. World-wide economic changes are forcing major changes in business and industry placing a premium on the power and value of knowledge and new knowledge production. These changes require changes in school and university education that centers on the nature and power of meaningful learning. New computer tools are available to facilitate teaching activities targeted at modifying LIPH's, and aiding meaningful learning in general.

  2. Demands–abilities fit, work beliefs, meaningful work and engagement in nature-based jobs

    Directory of Open Access Journals (Sweden)

    Nellie de Crom

    2018-03-01

    . Contribution or value-add: This study contributes to scientific knowledge regarding the effects of meaningful work and its antecedents on personal engagement.

  3. Prognostic value of 18F-choline PET/CT metabolic parameters in patients with metastatic castration-resistant prostate cancer treated with abiraterone or enzalutamide

    Energy Technology Data Exchange (ETDEWEB)

    Caroli, Paola; Fantini, Lorenzo; Celli, Monica; Paganelli, Giovanni; Matteucci, Federica [Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST) IRCCS, Nuclear Medicine Unit, Meldola (Italy); De Giorgi, Ugo; Conteduca, Vincenza; Rossi, Lorena [Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST) IRCCS, Department of Medical Oncology, Meldola (Italy); Scarpi, Emanuela [Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST) IRCCS, Unit of Biostatistics and Clinical Trials Unit, Meldola (Italy); Moretti, Andrea; Galassi, Riccardo [Morgagni Pierantoni Hospital, Nuclear Medicine Unit, Forli (Italy); Bianchi, Emanuela [Infermi Hospital, Department of Medical Oncology, Rimini (Italy)

    2018-03-15

    The role of 18F-choline positron emission tomography/computed tomography (FCH-PET/CT) in patients with metastatic castration-resistant prostate cancer (mCRPC) has been firmly established in recent years. We analyzed the prognostic value of functional parameters such as mean standardized uptake volume (SUVmean), maximum standardized uptake volume (SUVmax), metabolic total volume (MTV; the volume of interest consisting of all spatially connected voxels within a fixed threshold of 40% of the SUVmax), and total lesion activity (TLA: the product of MTV and mean standardized uptake value) estimated with FCH-PET/CT in mCRPC patients in progression after docetaxel and treated with new antiandrogen receptor therapies, abiraterone or enzalutamide. We retrospectively studied 94 mCRPC patients, mean age 74 years (range 42-90), previously treated with docetaxel who were treated with either abiraterone (n = 52) or enzalutamide (n = 42). An FCH-PET/CT was performed at baseline, and patients were evaluated on a monthly basis for serological PSA response and every 3 months for radiological response. We measured MTV, SUVmean, SUVmax and TLA for each lesion and analyzed the sum of MTV (SMTV), SUVmean (SSUVmean), SUVmax (SSUVmax) and TLA (STLA) values for a maximum of 20 lesions. Univariate analysis was used to correlate these data with PFS and OS. We observed a median SMTV of 130 cm{sup 3}, median SSUVmax of 106.5 and a median STLA of 495,070. All of these parameters were significant for PFS and OS in univariate analysis, while only STLA was significant for PFS and OS in multivariate analysis after adjusting for lesion and age (p < 0.0001 and p = 0.001, respectively). Baseline PSA values maintained a certain reliability for OS (p = 0.034). Semiquantitative parameters of FCH-PET/CT play a prognostic role in mCRCP patients treated with abiraterone or enzalutamide. (orig.)

  4. Are students ready for meaningful use?

    Directory of Open Access Journals (Sweden)

    Gary S. Ferenchick

    2013-11-01

    Full Text Available Background: The meaningful use (MU of electronic medical records (EMRs is being implemented in three stages. Key objectives of stage one include electronic analysis of data entered into structured fields, using decision-support tools (e.g., checking drug–drug interactions [DDI] and electronic information exchange. Objective: The authors assessed the performance of medical students on 10 stage-one MU tasks and measured the correlation between students’ MU performance and subsequent end-of-clerkship professionalism assessments and their grades on an end-of-year objective structured clinical examination. Participants: Two-hundred and twenty-two third-year medical students on the internal medicine (IM clerkship. Design/main measures: From July 2010 to February 2012, all students viewed 15 online tutorials covering MU competencies. The authors measured student MU documentation and performance in the chart of a virtual patient using a fully functional training EMR. Specific MU measurements included, adding: a new problem, a new medication, an advanced directive, smoking status, the results of screening tests; and performing a DDI (in which a major interaction was probable, and communicating a plan for this interaction. Key results: A total of 130 MU errors were identified. Sixty-eight (30.6% students had at least one error, and 30 (13.5% had more than one (range 2–6. Of the 130 errors, 90 (69.2% were errors in structured data entry. Errors occurred in medication dosing and instructions (18%, DDI identification (12%, documenting smoking status (15%, and colonoscopy results (23%. Students with MU errors demonstrated poorer performance on end-of-clerkship professionalism assessments (r=−0.112, p=0.048 and lower observed structured clinical examination (OSCE history-taking skills (r=−0.165, p=0.008 and communication scores (r=− 0.173, p=0.006. Conclusions: MU errors among medical students are common and correlate with subsequent poor

  5. Improved noninvasive prediction of liver fibrosis by liver stiffness measurement in patients with nonalcoholic fatty liver disease accounting for controlled attenuation parameter values.

    Science.gov (United States)

    Petta, Salvatore; Wong, Vincent Wai-Sun; Cammà, Calogero; Hiriart, Jean-Baptiste; Wong, Grace Lai-Hung; Marra, Fabio; Vergniol, Julien; Chan, Anthony Wing-Hung; Di Marco, Vito; Merrouche, Wassil; Chan, Henry Lik-Yuen; Barbara, Marco; Le-Bail, Brigitte; Arena, Umberto; Craxì, Antonio; de Ledinghen, Victor

    2017-04-01

    Liver stiffness measurement (LSM) frequently overestimates the severity of liver fibrosis in nonalcoholic fatty liver disease (NAFLD). Controlled attenuation parameter (CAP) is a new parameter provided by the same machine used for LSM and associated with both steatosis and body mass index, the two factors mostly affecting LSM performance in NAFLD. We aimed to determine whether prediction of liver fibrosis by LSM in NAFLD patients is affected by CAP values. Patients (n = 324) were assessed by clinical and histological (Kleiner score) features. LSM and CAP were performed using the M probe. CAP values were grouped by tertiles (lower 132-298, middle 299-338, higher 339-400 dB/m). Among patients with F0-F2 fibrosis, mean LSM values, expressed in kilopascals, increased according to CAP tertiles (6.8 versus 8.6 versus 9.4, P = 0.001), and along this line the area under the curve of LSM for the diagnosis of F3-F4 fibrosis was progressively reduced from lower to middle and further to higher CAP tertiles (0.915, 0.848-0.982; 0.830, 0.753-0.908; 0.806, 0.723-0.890). As a consequence, in subjects with F0-F2 fibrosis, the rates of false-positive LSM results for F3-F4 fibrosis increased according to CAP tertiles (7.2% in lower versus 16.6% in middle versus 18.1% in higher). Consistent with this, a decisional flowchart for predicting fibrosis was suggested by combining both LSM and CAP values. In patients with NAFLD, CAP values should always be taken into account in order to avoid overestimations of liver fibrosis assessed by transient elastography. (Hepatology 2017;65:1145-1155). © 2016 by the American Association for the Study of Liver Diseases.

  6. Diagnostic performance of conventional MRI parameters and apparent diffusion coefficient values in differentiating between benign and malignant soft-tissue tumours.

    Science.gov (United States)

    Song, Y; Yoon, Y C; Chong, Y; Seo, S W; Choi, Y-L; Sohn, I; Kim, M-J

    2017-08-01

    To compare the abilities of conventional magnetic resonance imaging (MRI) and apparent diffusion coefficient (ADC) in differentiating between benign and malignant soft-tissue tumours (STT). A total of 123 patients with STT who underwent 3 T MRI, including diffusion-weighted imaging (DWI), were retrospectively analysed using variate conventional MRI parameters, ADC mean and ADC min . For the all-STT group, the correlation between the malignant STT conventional MRI parameters, except deep compartment involvement, compared to those of benign STT were statistically significant with univariate analysis. Maximum diameter of the tumour (p=0.001; odds ratio [OR], 8.97) and ADC mean (p=0.020; OR, 4.30) were independent factors with multivariate analysis. For the non-myxoid non-haemosiderin STT group, signal heterogeneity on axial T1-weighted imaging (T1WI; p=0.017), ADC mean , and ADC min (p=0.001, p=0.001), showed significant differences with univariate analysis between malignancy and benignity. Signal heterogeneity in axial T1WI (p=0.025; OR, 12.64) and ADC mean (p=0.004; OR, 33.15) were independent factors with multivariate analysis. ADC values as well as conventional MRI parameters were useful in differentiating between benign and malignant STT. The ADC mean was the most powerful diagnostic parameter in non-myxoid non-haemosiderin STT. Copyright © 2017 The Royal College of Radiologists. Published by Elsevier Ltd. All rights reserved.

  7. Guidelines for Assessment of Gait and Reference Values for Spatiotemporal Gait Parameters in Older Adults: The Biomathics and Canadian Gait Consortiums Initiative

    Directory of Open Access Journals (Sweden)

    Olivier Beauchet

    2017-08-01

    Full Text Available Background: Gait disorders, a highly prevalent condition in older adults, are associated with several adverse health consequences. Gait analysis allows qualitative and quantitative assessments of gait that improves the understanding of mechanisms of gait disorders and the choice of interventions. This manuscript aims (1 to give consensus guidance for clinical and spatiotemporal gait analysis based on the recorded footfalls in older adults aged 65 years and over, and (2 to provide reference values for spatiotemporal gait parameters based on the recorded footfalls in healthy older adults free of cognitive impairment and multi-morbidities.Methods: International experts working in a network of two different consortiums (i.e., Biomathics and Canadian Gait Consortium participated in this initiative. First, they identified items of standardized information following the usual procedure of formulation of consensus findings. Second, they merged databases including spatiotemporal gait assessments with GAITRite® system and clinical information from the “Gait, cOgnitiOn & Decline” (GOOD initiative and the Generation 100 (Gen 100 study. Only healthy—free of cognitive impairment and multi-morbidities (i.e., ≤ 3 therapeutics taken daily—participants aged 65 and older were selected. Age, sex, body mass index, mean values, and coefficients of variation (CoV of gait parameters were used for the analyses.Results: Standardized systematic assessment of three categories of items, which were demographics and clinical information, and gait characteristics (clinical and spatiotemporal gait analysis based on the recorded footfalls, were selected for the proposed guidelines. Two complementary sets of items were distinguished: a minimal data set and a full data set. In addition, a total of 954 participants (mean age 72.8 ± 4.8 years, 45.8% women were recruited to establish the reference values. Performance of spatiotemporal gait parameters based on the recorded

  8. Predictive value of different conventional and non-conventional MRI-parameters for specific domains of cognitive function in multiple sclerosis.

    Science.gov (United States)

    Pinter, Daniela; Khalil, Michael; Pichler, Alexander; Langkammer, Christian; Ropele, Stefan; Marschik, Peter B; Fuchs, Siegrid; Fazekas, Franz; Enzinger, Christian

    2015-01-01

    While many studies correlated cognitive function with changes in brain morphology in multiple sclerosis (MS), few of them used a multi-parametric approach in a single dataset so far. We thus here assessed the predictive value of different conventional and quantitative MRI-parameters both for overall and domain-specific cognitive performance in MS patients from a single center. 69 patients (17 clinically isolated syndrome, 47 relapsing-remitting MS, 5 secondary-progressive MS) underwent the "Brief Repeatable Battery of Neuropsychological Tests" assessing overall cognition, cognitive efficiency and memory function as well as MRI at 3 Tesla to obtain T2-lesion load (T2-LL), normalized brain volume (global brain volume loss), normalized cortical volume (NCV), normalized thalamic volume (NTV), normalized hippocampal volume (NHV), normalized caudate nuclei volume (NCNV), basal ganglia R2* values (iron deposition) and magnetization transfer ratios (MTRs) for cortex and normal appearing brain tissue (NABT). Regression models including clinical, demographic variables and MRI-parameters explained 22-27% of variance of overall cognition, 17-26% of cognitive efficiency and 22-23% of memory. NCV, T2-LL and MTR of NABT were the strongest predictors of overall cognitive function. Cognitive efficiency was best predicted by NCV, T2-LL and iron deposition in the basal ganglia. NTV was the strongest predictor for memory function and NHV was particularly related to memory function. The predictive value of distinct MRI-parameters differs for specific domains of cognitive function, with a greater impact of cortical volume, focal and diffuse white matter abnormalities on overall cognitive function, an additional role of basal ganglia iron deposition on cognitive efficiency, and thalamic and hippocampal volume on memory function. This suggests the usefulness of using multiparametric MRI to assess (micro)structural correlates of different cognitive constructs.

  9. High grade intraepithelial neoplasia of prostate is associated with values of prostate specific antigen related parameters intermediate between prostate cancer and normal levels

    Directory of Open Access Journals (Sweden)

    Nermina Obralic

    2011-11-01

    Full Text Available High grade prostatic intraepithelial neoplasia (HGPIN is widely regarded as the precancerous. The aim of this study was to determine PSA related parameters in patients with initial PSA values 2-10 ng/mL and diagnosis of HGPIN without finding carcinoma at the time of their first needle biopsy. Study groups consisted of 100 men who were diagnosed HGPIN, 84 with cancer and 183 with benign hyperplasia on first biopsy of prostate. Total PSA and free PSA were measured and ratio free/total PSA and PSA density calculated. Mean values of these parameters were compared, and receiver operating characteristic curves were used for comparison of PSA related parameters to discriminate groups of patients. Total PSA, free PSA level and PSA density in patients with HGPIN (6.388 ng/mL did not differ significantly compared to prostate carcinoma (6.976 ng/mL or benign prostatic hyperplasia (6.07 ng/mL patients. Patients with HGPIN had significantly higher ratio free/total PSA than those with prostate carcinoma (0.168 vs 0.133, but significantly lower than patients with benign prostatic hyperplasia (0.168 vs 0.185. Ratio of free/total PSA significantly discriminate HGPIN from prostate carcinoma with sensitivity 84.52 and specify 45.00 at cut-off point of ≤ 0.18. Values of PSA, free PSA and ratio free/total PSA in cases of HGPIN appear to be intermediate between prostate cancer and normal levels. Ratio of free/total PSA may help in decision to repeat biopsies in the presence of HGPIN on biopsy, without concomitant prostate cancer, in patients suitable for curative treatment, with normal digito-rectal examination and trans-rectal sonography.

  10. Meaningful Use of Health Information Technology by Rural Hospitals

    Science.gov (United States)

    McCullough, Jeffrey; Casey, Michelle; Moscovice, Ira; Burlew, Michele

    2011-01-01

    Purpose: This study examines the current status of meaningful use of health information technology (IT) in Critical Access Hospitals (CAHs), other rural, and urban US hospitals, and it discusses the potential role of Medicare payment incentives and disincentives in encouraging CAHs and other rural hospitals to achieve meaningful use. Methods: Data…

  11. Characteristics of meaningful chemistry education - The case of water quality

    NARCIS (Netherlands)

    Westbroek, Hanna Barbara

    2005-01-01

    This thesis addresses the question of how to involve students in meaningful chemistry education by a proper implementation of three characteristics of meaningful: a context, a need-to-know approach and attention for student input. The characteristics were adopted as solution strategies for

  12. Relationship between meaningful work and job performance in nurses.

    Science.gov (United States)

    Tong, Ling

    2018-04-01

    The present study was designed to determine the relationship between meaningful work and job performance, and the impact of meaningful work on nursing care quality. Meaningful work has been suggested as a significant factor affecting job performance, but the relationship has never been studied in nurses in China. A descriptive correlational study was designed to assess the level of meaningful work, tasks, and contextual performance as well as their relationships. We used a stratified random-sampling approach to enrol nurses from hospitals. Multivariate regression analysis was applied to determine the relationship between meaningful work and their demographic data. There were significant, positive relationships between meaningful work and task performance and contextual performance. Education level, work unit, and employment type influenced meaningful work. The work motivation score of the nurses was lower than that of the other 2 dimensions, and a negative work motivation score negatively influenced job performance. Improving meaningful work and providing more support and assistance could improve nurse performance, thereby improving the quality of nursing care. © 2018 John Wiley & Sons Australia, Ltd.

  13. Self-Determination and Meaningful Work: Exploring Socioeconomic Constraints

    Directory of Open Access Journals (Sweden)

    Blake A Allan

    2016-02-01

    Full Text Available This study examined a model of meaningful work among a diverse sample of working adults. From the perspectives of Self-Determination Theory and the Psychology of Working Framework, we tested a structural model with social class and work volition predicting SDT motivation variables, which in turn predicted meaningful work. Partially supporting hypotheses, work volition was positively related to internal regulation and negatively related to amotivation, whereas social class was positively related to external regulation and amotivation. In turn, internal regulation was positively related to meaningful work, whereas external regulation and amotivation were negatively related to meaningful work. Indirect effects from work volition to meaningful work via internal regulation and amotivation were significant, and indirect effects from social class to meaningful work via external regulation and amotivaiton were significant. This study highlights the important relations between SDT motivation variables and meaningful work, especially the large positive relation between internal regulation and meaningful work. However, results also reveal that work volition and social class may play critical roles in predicting internal regulation, external regulation, and amotivation.

  14. Self-Determination and Meaningful Work: Exploring Socioeconomic Constraints.

    Science.gov (United States)

    Allan, Blake A; Autin, Kelsey L; Duffy, Ryan D

    2016-01-01

    This study examined a model of meaningful work among a diverse sample of working adults. From the perspectives of Self-Determination Theory and the Psychology of Working Framework, we tested a structural model with social class and work volition predicting SDT motivation variables, which in turn predicted meaningful work. Partially supporting hypotheses, work volition was positively related to internal regulation and negatively related to amotivation, whereas social class was positively related to external regulation and amotivation. In turn, internal regulation was positively related to meaningful work, whereas external regulation and amotivation were negatively related to meaningful work. Indirect effects from work volition to meaningful work via internal regulation and amotivation were significant, and indirect effects from social class to meaningful work via external regulation and amotivation were significant. This study highlights the important relations between SDT motivation variables and meaningful work, especially the large positive relation between internal regulation and meaningful work. However, results also reveal that work volition and social class may play critical roles in predicting internal regulation, external regulation, and amotivation.

  15. Meaningful work and secondary school teachers' intention to leave ...

    African Journals Online (AJOL)

    The following measuring instruments were used: Work-role Fit Scale, Job Enrichment Scale, Co-worker and Supervisor Relationships Scales, Psychological Meaningfulness Scale and Turnover Intention Scale. Work-role fit and job enrichment both had direct positive effect on experiences of psychological meaningfulness at ...

  16. Between order and chaos: The quest for meaningful information

    NARCIS (Netherlands)

    Adriaans, P.

    2009-01-01

    The notion of meaningful information seems to be associated with the sweet spot between order and chaos. This form of meaningfulness of information, which is primarily what science is interested in, is not captured by both Shannon information and Kolmogorov complexity. In this paper I develop a

  17. Meaningful spatial and temporal sequences of activities in dwelling

    NARCIS (Netherlands)

    Hematalikeikha, M.A.; Coolen, H.C.C.H.; Pourdeihimi, S.

    2014-01-01

    Human activities based on human needs are affected by affordances and meanings that occur in the dwelling. Activities over time and space have meaningful sequences. The meaningfulness of activities in the cultural framework is conditioned by its special temporality and spatiality. Also, temporal or

  18. Meaningful work and secondary school teachers' intention to leave

    Directory of Open Access Journals (Sweden)

    M. Janik

    2015-05-01

    Full Text Available The study investigates the relations between secondary school teachers' work-role fit, job enrichment, supervisor relationships, co-worker relationships, psychological meaningfulness of work and intention to leave. A cross-sectional survey was used. The participants were 502 secondary school teachers in Namibia. The following measuring instruments were used: Work-role Fit Scale, Job Enrichment Scale, Co-worker and Supervisor Relationships Scales, Psychological Meaningfulness Scale and Turnover Intention Scale. Work-role fit and job enrichment both had direct positive effect on experiences of psychological meaningfulness at work, while poor work-role fit and low psychological meaningfulness both had a direct effect on teachers' intentions to leave. An analysis of the indirect effects showed that poor work-role fit and poor job enrichment affected intention to leave due to the concomitant experience of low psychological meaningfulness. These findings have implications for the retention of teachers in secondary schools.

  19. Identification of Combined Power Quality Disturbances Using Singular Value Decomposition (SVD and Total Least Squares-Estimation of Signal Parameters via Rotational Invariance Techniques (TLS-ESPRIT

    Directory of Open Access Journals (Sweden)

    Huaishuo Xiao

    2017-11-01

    Full Text Available In order to identify various kinds of combined power quality disturbances, the singular value decomposition (SVD and the improved total least squares-estimation of signal parameters via rotational invariance techniques (TLS-ESPRIT are combined as the basis of disturbance identification in this paper. SVD is applied to identify the catastrophe points of disturbance intervals, based on which the disturbance intervals are segmented. Then the improved TLS-ESPRIT optimized by singular value norm method is used to analyze each data segment, and extract the amplitude, frequency, attenuation coefficient and initial phase of various kinds of disturbances. Multi-group combined disturbance test signals are constructed by MATLAB and the proposed method is also tested by the measured data of IEEE Power and Energy Society (PES Database. The test results show that the new method proposed has a relatively higher accuracy than conventional TLS-ESPRIT, which could be used in the identification of measured data.

  20. The effect of intake of water on the final values of body composition parameters in active athletes using two different bioimpedance analyzers

    Directory of Open Access Journals (Sweden)

    Petr Kutáč

    2014-06-01

    Full Text Available Background:The method of bioelectrical impedance (BIA is frequently used to estimate body composition in sports. The total body water (TBW is the basic variable that BIA measures. That implies the degree of sensitivity of BIA to the hydration of the organism, which is also demonstrated by the principles of measurement that primarily relate to the hydration of the organism. It is difficult to provide standard hydration of the organism of subjects prior to measurements when taking the measurements in the field. Objective:The objective of the study is to assess the changes in the final values of the selected body composition parameters in soccer players caused by intake of water, using two devices commonly used in the field. Methods:The research was performed in a group of 33 soccer players (mean age 20.30 ± 1.18 years. The measurements were taken using Tanita BC 418 MA (frequency 50 kHz and Nutriguard-M (frequency 100 kHz. To evaluate the effect of water intake, we took two measurements before and after the intake of 500 ml of water. The parameters measured by Tanita BC 418 MA were body weight (BW, total body water (TBW, body fat (BF, fat free mass (FFM. Nutriguard-M was used to measure total body water (TBW, intra and extracellular water (ICW and ECW, body fat (BF, fat free mass (FFM, intra and extracellular mass (BCM and ECM. The differences in the means (M1 and M2 of the monitored parameters were evaluated using the Paired Samples t-test. In statistically significant differences in the mean, the practical significance was also verified using the effect of size (Cohen's d. Results:The Tanita device showed statistically significant differences after the intake of 500 ml in parameters BW (+0.42 kg, BF (+0.39 kg, +0.53% and TBW (-0.38%. As for the Nutriguard device, statistically significant differences were found in parameters TBW (+0.77 kg, ICW (+0.83 kg, FFM (+1.05 kg, BCM (+0.79 kg and ECM/BCM (-0.01. Conclusion

  1. Maximum standard uptake value on pre-chemotherapeutic FDG-PET is a significant parameter for disease progression of newly diagnosed lymphoma

    International Nuclear Information System (INIS)

    Eo, Jae Seon; Lee, Won Woo; Chung, June Key; Lee, Myung Chul; Kim, Sang Eun

    2005-01-01

    F-18 FDG-PET is useful for detection and staging of lymphoma. We investigated the prognostic significance of maximum standard uptake (maxSUV) value of FDG-PET for newly diagnosed lymphoma patients before chemotherapy. Twenty-seven patients (male: female = 17: 10: age: 49±19 years) with newly diagnosed lymphoma were enrolled. Nine-teen patients suffered from B cell lymphoma, 6 Hodgkins disease and 2 T cell lymphoma. One patient was stage I, 9 stage II, 3 stage III, 1 stage IV and 13 others. All patients underwent FDG-PET before initiation of chemotherapy. MaxSUV values using lean body weight were obtained for main and largest lesion to represent maxSUV of the patients. The disease progression was defined as total change of the chemotherapeutic regimen or addition of new chemotherapeutic agent during follow up period. The observed period was 389±224 days. The value of maxSUV ranged from 3 to 18 (mean±SD = 10.6±4.4). The disease progressions occurred in 6 patients. Using Cox proportional-hazard regression analysis, maxSUV was identified as a significant parameter for the disease progression free survival (p=0.044). Kaplan-Meier survival curve analysis revealed that the group with higher maxSUV (=10.6, n=5) suffered from shorter disease progression free survival (median 299 days) than the group with lower maxSUV (<10.6, n = 22) (median 378 days, p=0.0146). We found that maxSUV on pre-chemotherapeutic F-18 FDG-PET for newly diagnosed lymphoma patients is a significant parameter for disease progression. Lymphoma patients can be stratified before initiation of chemotherapy in terms of disease progression by the value of maxSUV 10.6

  2. Contrast-enhanced magnetic resonance imaging of the breast: the value of pharmacokinetic parameters derived from fast dynamic imaging during initial enhancement in classifying lesions

    International Nuclear Information System (INIS)

    Veltman, J.; Stoutjesdijk, M.; Mann, R.; Huisman, H.J.; Barentsz, J.O.; Blickman, J.G.; Boetes, C.

    2008-01-01

    The value of pharmacokinetic parameters derived from fast dynamic imaging during initial enhancement in characterizing breast lesions on magnetic resonance imaging (MRI) was evaluated. Sixty-eight malignant and 34 benign lesions were included. In the scanning protocol, high temporal resolution imaging was combined with high spatial resolution imaging. The high temporal resolution images were recorded every 4.1 s during initial enhancement (fast dynamic analysis). The high spatial resolution images were recorded at a temporal resolution of 86 s (slow dynamic analysis). In the fast dynamic evaluation pharmacokinetic parameters (K trans , V e and k ep ) were evaluated. In the slow dynamic analysis, each lesion was scored according to the BI-RADS classification. Two readers evaluated all data prospectively. ROC and multivariate analysis were performed. The slow dynamic analysis resulted in an AUC of 0.85 and 0.83, respectively. The fast dynamic analysis resulted in an AUC of 0.83 in both readers. The combination of both the slow and fast dynamic analyses resulted in a significant improvement of diagnostic performance with an AUC of 0.93 and 0.90 (P = 0.02). The increased diagnostic performance found when combining both methods demonstrates the additional value of our method in further improving the diagnostic performance of breast MRI. (orig.)

  3. Values of some topographic parameters of optic nerve head obtained by Heidelberg retina tomograph II in volunteers and different stage primary open-angle glaucoma patients

    Directory of Open Access Journals (Sweden)

    B. Anguelov

    2013-01-01

    Full Text Available Purpose: То assess the values of the top five topographic parameters of optic nerve head (ONH obtained by Heidelberg retina tomograph (HRT II in volunteers and primary open angle glaucoma (POAG patients with different stage of perimetric changes.Methods: 73 eyes (38 volunteers at the age of 56 years ±13, 11 men and 27 women and 170 eyes (90 patients at the age of 66 years ±12, 33 men and 57 women were examined. We performed the comprehensive ophthalmic examination, standard automated perimetry and measurement of the top five topographic parameters of ONH — rim area, rim volume, cup shape measure, height variation contour и mean RNFL thickness. For the purpose of this study we used HRT II.Results: We determine the values of the investigated topographic parameters of the ONH for healthy volunteers (rim area = 1.68±0.22 mm2, rim volume = 0.44±0.07 mm3, cup shape measure = –0.2±0.06, height variation contour = 0.38±0.08 mm and mean RNFL thickness = 0.24±0.03 mm and for the patients in different perimetric glaucoma stages (early stage: rim area = 1.52±0.47 mm2, rim volume = 0.38±0.17 mm3, cup shape measure = –0.14±0.1, height variation contour = 0.36±0.09 mm and mean RNFL thickness = 0.22±0.11 mm; moderate stage: rim area = 1.21±0.46 mm2, rim volume = 0.27±0.17 mm3, cup shape measure = –0.09±0.1, height variation contour = 0.36±0.17 mm and mean RNFL thickness = 0.16±0.12 mm; severe stage: rim area = 0.97±0.01 mm2, rim volume = 0.18±0.17 mm3, cup shape measure = –0.06±0.1, height variation contour = 0.28±0.11 mm and mean RNFL thickness = 0.17±0.11 mm. Hodapp-Parrish-Anderson (H-P-A ’s staging system includes three separate levels (early, moderate and severe of glaucoma according to visual field defects. Each stage is additionally characterized by the values of the top five topographic parameters of the ONH.Conclusion: Early diagnosis, staging and follow-up of POAG are based on both function and

  4. Analysis of the effect of variations in parameter values on the predicted radiological consequences of geologic disposal of high-level waste

    International Nuclear Information System (INIS)

    Hill, M.D.

    1979-06-01

    A preliminary assessment of the radiological consequences of geologic disposal of high-level waste (Hill and Grimwood. NRPB-R69 (1978)) identified several areas where further research is required before this disposal option can be fully evaluated. This report is an analysis of the sensitivity of the results of the preliminary assessment to the assumptions made and the values of the parameters used. The parameters considered include the leach rate of the waste, the ground-water velocity, the length of the flow path from the repository to a source of drinking water and the sorption constants of the principle radionuclides. The results obtained by varying these parameters are used to examine the effects of assumptions such as the time at which leaching of the waste begins. The sensitivity analysis shows the relative importance of the waste canisters, the waste form and the geologic barrier to radionuclide migration in determining potential doses. These results are used to identify research priorities, establish preliminary design criteria and indicate developments needed in the mathematical modelling of the movement of radionuclides from a repository to the biosphere. (author)

  5. Prognostic Value of Volume-Based {sup 18}F-Fluorodeoxyglucose PET/CT Parameters in Patients with Clinically Node-Negative Oral Tongue Squamous Cell Carcinoma

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Su Jin [Dept. of Nuclear Medicine, Ajou University School of Medicine, Suwon (Korea, Republic of); Choi, Joon Young; Lee, Hwan Joo; Hyun, Seung Hyup; Moon, Seung Hwan; Kim, Byung Tae [Dept. of Nuclear Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul (Korea, Republic of); Baek, Chung Hwan; Son, Young Ik [Dept. of Otorhinolaryngology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul (Korea, Republic of)

    2012-11-15

    To evaluate the prognostic value of volume-based metabolic parameters measured with {sup 18}F-fluorodeoxyglucose ({sup 18}F-FDG) positron emission tomography (PET) in patients with clinically node-negative (cN0) oral tongue squamous cell carcinoma (OTSCC) as compared with other prognostic factors. In this study, we included a total of 57 patients who had been diagnosed with cN0 tongue cancer by radiologic, ({sup 18}F-FDG PET/CT, and physical examinations. The maximum standardized uptake value (SUVmax), average SUV (SUVavg), metabolic tumor volume (MTV), and total lesion glycolysis (TLG) for primary tumors were measured with ({sup 18}F-FDG PET. The prognostic significances of these parameters and other clinical variables were assessed by Cox proportional hazards regression analysis. In the univariate analysis, pathological node (pN) stage, American Joint Committee on Cancer (AJCC) stage, SUVmax, SUVavg, MTV, and TLG were significant predictors for survival. On a multivariate analysis, pN stage (hazard ratio = 10.555, p = 0.049), AJCC stage (hazard ratio = 13.220, p = 0.045), and MTV (hazard ratio = 2.698, p 0.033) were significant prognostic factors in cN0 OTSCC patients. The patients with MTV {>=} 7.78 cm{sup 3} showed a worse prognosis than those with MTV < 7.78 cm{sup 3} (p = 0.037). The MTV of primary tumor as a volumetric parameter of ({sup 18}F-FDG PET, in addition to pN stage and AJCC stage, is an independent prognostic factor for survival in cN0 OTSCC.

  6. The prognostic value of functional and anatomical parameters for the selection of patients receiving yttrium-90 microspheres for the treatment of liver cancer

    Science.gov (United States)

    Mesoloras, Geraldine

    Yttrium-90 (90Y) microsphere therapy is being utilized as a treatment option for patients with primary and metastatic liver cancer due to its ability to target tumors within the liver. The success of this treatment is dependent on many factors, including the extent and type of disease and the nature of prior treatments received. Metabolic activity, as determined by PET imaging, may correlate with the number of viable cancer cells and reflect changes in viable cancer cell volume. However, contouring of PET images by hand is labor intensive and introduces an element of irreproducibility into the determination of functional target/tumor volume (FTV). A computer-assisted method to aid in the automatic contouring of FTV has the potential to substantially improve treatment individualization and outcome assessment. Commercial software to determine FTV in FDG-avid primary and metastatic liver tumors has been evaluated and optimized. Volumes determined using the automated technique were compared to those from manually drawn contours identified using the same cutoff in the standard uptake value (SUV). The reproducibility of FTV is improved through the introduction of an optimal threshold value determined from phantom experiments. Application of the optimal threshold value from the phantom experiments to patient scans was in good agreement with hand-drawn determinations of the FTV. It is concluded that computer-assisted contouring of the FTV for primary and metastatic liver tumors improves reproducibility and increases accuracy, especially when combined with the selection of an optimal SUV threshold determined from phantom experiments. A method to link the pre-treatment assessment of functional (PET based) and anatomical (CT based) parameters to post-treatment survival and time to progression was evaluated in 22 patients with colorectal cancer liver metastases treated using 90Y microspheres and chemotherapy. The values for pre-treatment parameters that were the best

  7. What constitutes meaningful engagement for patients and families as partners on research teams?

    Science.gov (United States)

    Black, Agnes; Strain, Kimberly; Wallsworth, Christine; Charlton, Sara-Grey; Chang, Wilma; McNamee, Kate; Hamilton, Clayon

    2018-01-01

    Objective There is growing emphasis on health care organizations to ensure that lay people are meaningfully engaged as partners on research teams. Our aim was to explore the perspectives of patients, family members and informal caregivers who have been involved on health care research teams in Canada and elicit their recommendations for meaningful engagement. Methods We conducted a qualitative study guided by thematic analysis of transcripts of focus groups and interviews of 19 experienced patient research partners in Canada. Results We identified four main themes: research environment, expectations, support and value, which highlight participants' combined perspectives on important factors to ensure their engagement in research is meaningful. Conclusions Our findings add to the evolving evidence base on the perspectives of lay people involved in health care research and their recommendations for research leaders on meaningful engagement. Our study suggests that research leaders should provide a welcoming research environment, outline appropriate expectations for patient research partners on research teams, support patient research partners' engagement in projects and recognize the value patient research partners bring to health research.

  8. Relationship between myocardial T2* values and cardiac volumetric and functional parameters in β-thalassemia patients evaluated by cardiac magnetic resonance in association with serum ferritin levels

    Energy Technology Data Exchange (ETDEWEB)

    Liguori, Carlo, E-mail: c.liguori@unicampus.it [Department of Diagnostic Imaging, Campus Bio Medico University, via Alvaro del Portillo 200, 00128 Rome (Italy); Pitocco, Francesca, E-mail: f.pitocco@unicampus.it [Department of Diagnostic Imaging, Campus Bio Medico University, via Alvaro del Portillo 200, 00128 Rome (Italy); Di Giampietro, Ilenia, E-mail: i.digiampietro@unicampus.it [Department of Diagnostic Imaging, Campus Bio Medico University, via Alvaro del Portillo 200, 00128 Rome (Italy); Vivo, Aldo Eros de, E-mail: devivoeros@gmail.com [Department of Diagnostic Imaging, Campus Bio Medico University, via Alvaro del Portillo 200, 00128 Rome (Italy); Schena, Emiliano, E-mail: e.schena@unicampus.it [Unit of Measurements and Biomedical Instrumentation, Campus Bio Medico University, via Alvaro del Portillo 200, 00128 Rome (Italy); Cianciulli, Paolo, E-mail: CIANCIULLI.PAOLO@aslrmc.it [Thalassemia Unit, Ospedale Sant Eugenio, Piazzale dell’Umanesimo 10, 00143 Rome (Italy); Zobel, Bruno Beomonte, E-mail: b.zobel@unicampus.it [Department of Diagnostic Imaging, Campus Bio Medico University, via Alvaro del Portillo 200, 00128 Rome (Italy)

    2013-09-15

    Purpose: Myocardial T2* cardiovascular magnetic resonance provides a rapid and reproducible assessment of cardiac iron load in thalassemia patients. Although cardiac involvement is mainly characterized by left ventricular dysfunction caused by iron overload, little is known about right ventricular function. The aim of this study was to assess the relationship between T2* value in myocardium and left–right ventricular volumetric and functional parameters and to evaluate the existing associations between left–right ventricles volumetric and functional parameter, myocardial T2* values and blood ferritin levels. Materials and methods: A retrospective analysis of 208 patients with β-thalassemia major and thalassemia intermedia was performed (109 males and 99 females; mean age 37.7 ± 13 years; 143 thalassemia major, 65 thalassemia intermedia). Myocardial iron load was assessed by T2* measurements, and volumetric functions were analyzed using the steady state free precession sequence. Results: A significant correlation was observed between EFLV and T2* (p = 0.0001), EFRV and T2* (p = 0.0279). An inverse correlation was present between DVLV and T2* (p = 0.0468), SVLV and T2* (p = 0.0003), SVRV and T2* (p = 0.0001). There was no significant correlation between cardiac T2* and LV–RV mass indices. A significant correlation was observed between T2* and serum ferritin levels (p < 0.001) and between EFLV and serum ferritin (p < 0.05). Conclusion: Myocardial iron load assessed by T2* cardiac magnetic resonance is associated with deterioration in left–right ventricular function; this is more evident when T2* values fall below 14 ms. CMR appears to be a promising approach for cardiac risk evaluation in TM patients.

  9. Relationship between myocardial T2* values and cardiac volumetric and functional parameters in β-thalassemia patients evaluated by cardiac magnetic resonance in association with serum ferritin levels

    International Nuclear Information System (INIS)

    Liguori, Carlo; Pitocco, Francesca; Di Giampietro, Ilenia; Vivo, Aldo Eros de; Schena, Emiliano; Cianciulli, Paolo; Zobel, Bruno Beomonte

    2013-01-01

    Purpose: Myocardial T2* cardiovascular magnetic resonance provides a rapid and reproducible assessment of cardiac iron load in thalassemia patients. Although cardiac involvement is mainly characterized by left ventricular dysfunction caused by iron overload, little is known about right ventricular function. The aim of this study was to assess the relationship between T2* value in myocardium and left–right ventricular volumetric and functional parameters and to evaluate the existing associations between left–right ventricles volumetric and functional parameter, myocardial T2* values and blood ferritin levels. Materials and methods: A retrospective analysis of 208 patients with β-thalassemia major and thalassemia intermedia was performed (109 males and 99 females; mean age 37.7 ± 13 years; 143 thalassemia major, 65 thalassemia intermedia). Myocardial iron load was assessed by T2* measurements, and volumetric functions were analyzed using the steady state free precession sequence. Results: A significant correlation was observed between EFLV and T2* (p = 0.0001), EFRV and T2* (p = 0.0279). An inverse correlation was present between DVLV and T2* (p = 0.0468), SVLV and T2* (p = 0.0003), SVRV and T2* (p = 0.0001). There was no significant correlation between cardiac T2* and LV–RV mass indices. A significant correlation was observed between T2* and serum ferritin levels (p < 0.001) and between EFLV and serum ferritin (p < 0.05). Conclusion: Myocardial iron load assessed by T2* cardiac magnetic resonance is associated with deterioration in left–right ventricular function; this is more evident when T2* values fall below 14 ms. CMR appears to be a promising approach for cardiac risk evaluation in TM patients

  10. Measuring Patient Experiences: Is It Meaningful and Actionable?

    Science.gov (United States)

    Wong, Sabrina T; Johnston, Sharon; Burge, Fred; McGrail, Kim; Hogg, William

    2017-10-01

    Performance measurement must be meaningful to those being asked to contribute data and to the clinicians who are collecting the information. It must be actionable if performance measurement and reporting is to influence health system transformation. To date, measuring patient experiences in all parts of the healthcare system in Canada lags behind other countries. More attention needs to be paid to capturing patients with complex intersecting health and social problems that result from inequitable distribution of wealth and/or underlying structural inequities related to systemic issues such as racism and discrimination, colonialism and patriarchy. Efforts to better capture the experiences of patients who do not regularly access care and who speak English or French as a second language are also needed. Before investing heavily into collecting patient experience data as part of a performance measurement system the following ought to be considered: (1) ensuring value for and buy-in from clinicians who are being asked to collect the data and/or act on the results; (2) investment in the infrastructure to administer iterative, cost-effective patient/family experience data collection, analysis and reporting (e.g., automated software tools) and (3) incorporating practice support (e.g., facilitation) and health system opportunities to integrate the findings from patient experience surveys into policy and practice. Investment into the infrastructure of measuring, reporting and engaging clinicians in improving practice is needed for patient/caregiver experiences to be acted upon. © 2017 Longwoods Publishing.

  11. Callings, work role fit, psychological meaningfulness and work ...

    African Journals Online (AJOL)

    meaningful work experiences, which also impact individuals' work .... group 25 to 29 years. .... significant chi-squared difference tests, after these path deletions, indicated that .... Counseling Psychology, 59:479-485. doi: 10.1037/a0028949.

  12. Poignancy: Mixed Emotional Experience in the Face of Meaningful Endings

    Science.gov (United States)

    Ersner-Hershfield, Hal; Mikels, Joseph A.; Sullivan, Sarah J.; Carstensen, Laura L.

    2009-01-01

    The experience of mixed emotions increases with age. Socioemotional selectivity theory suggests that mixed emotions are associated with shifting time horizons. Theoretically, perceived constraints on future time increase appreciation for life, which, in turn, elicits positive emotions such as happiness. Yet, the very same temporal constraints heighten awareness that these positive experiences come to an end, thus yielding mixed emotional states. In 2 studies, the authors examined the link between the awareness of anticipated endings and mixed emotional experience. In Study 1, participants repeatedly imagined being in a meaningful location. Participants in the experimental condition imagined being in the meaningful location for the final time. Only participants who imagined “last times” at meaningful locations experienced more mixed emotions. In Study 2, college seniors reported their emotions on graduation day. Mixed emotions were higher when participants were reminded of the ending that they were experiencing. Findings suggest that poignancy is an emotional experience associated with meaningful endings. PMID:18179325

  13. Readiness for Meaningful Use of Health Information Tech...

    Data.gov (United States)

    U.S. Department of Health & Human Services — According to findings reported in Readiness for Meaningful Use of Health Information Technology and Patient Centered Medical Home Recognition Survey Results,...

  14. Lattice parameters values and phase diagram for the Cu{sub 2}Zn{sub 1-z}Fe{sub z}GeSe{sub 4} alloy system

    Energy Technology Data Exchange (ETDEWEB)

    Caldera, D. [Centro de Estudios de Semiconductores, Departamento de Fisica, Facultad de Ciencias, Universidad de Los Andes, Merida 5101 (Venezuela); Quintero, M. [Centro de Estudios de Semiconductores, Departamento de Fisica, Facultad de Ciencias, Universidad de Los Andes, Merida 5101 (Venezuela)], E-mail: mquinter@ula.ve; Morocoima, M.; Quintero, E.; Grima, P.; Marchan, N.; Moreno, E.; Bocaranda, P. [Centro de Estudios de Semiconductores, Departamento de Fisica, Facultad de Ciencias, Universidad de Los Andes, Merida 5101 (Venezuela); Delgado, G.E. [Laboratorio de Cristalografia, Departamento de Quimica, Facultad de Ciencias, Universidad de Los Andes, Merida 5101 (Venezuela); Mora, A.E.; Briceno, J.M.; Fernandez, J.L. [Laboratorio de Analisis Quimico y Estructura de Materiales, Departamento de Fisica, Universidad de Los Andes, Merida 5101 (Venezuela)

    2008-06-12

    X-ray powder diffraction and differential thermal analysis (DTA) measurements were made on polycrystalline samples of the Cu{sub 2}Zn{sub 1-z}Fe{sub z}GeSe{sub 4} alloy system. The diffraction patterns were used to show the equilibrium conditions and to estimate crystalline parameter values. It was found that, at room temperature, a single phase solid solution with the tetragonal stannite {alpha} structure (I4-bar2m) occurs across the whole composition range. The DTA thermograms were used to construct the phase diagram of the Cu{sub 2}Zn{sub 1-z}Fe{sub z}GeSe{sub 4} alloy system. It was confirmed that the Cu{sub 2}ZnGeSe{sub 4} compound melts incongruently. It was observed that undercooling effects occur for samples with z > 0.9.

  15. The importance of culturally meaningful activity for health benefits among older Korean immigrant living in the United States

    Directory of Open Access Journals (Sweden)

    Junhyoung Kim

    2015-06-01

    Full Text Available Research indicates that participation in culturally meaningful activity is beneficial for immigrants’ health and well-being, yet older Korean immigrants struggle with accepting new cultural perspectives, which can negatively affect their health and well-being. Using in-depth interviews, this study was designed to capture the value of culturally meaningful activities for health among older Korean immigrants. Three themes were identified: (a improved psychological well-being, (b enhanced positive emotions and feelings, and (c social connections developed with others. The findings suggest that by engaging in various culturally meaningful activities, older Korean immigrants gain a sense of social, cultural, and psychological significance in life. This study also provided evidence that older Korean immigrants maintain and develop their cultural identity through culturally meaningful activities.

  16. The importance of culturally meaningful activity for health benefits among older Korean immigrant living in the United States.

    Science.gov (United States)

    Kim, Junhyoung; Kim, May; Han, Areum; Chin, Seungtae

    2015-01-01

    Research indicates that participation in culturally meaningful activity is beneficial for immigrants' health and well-being, yet older Korean immigrants struggle with accepting new cultural perspectives, which can negatively affect their health and well-being. Using in-depth interviews, this study was designed to capture the value of culturally meaningful activities for health among older Korean immigrants. Three themes were identified: (a) improved psychological well-being, (b) enhanced positive emotions and feelings, and (c) social connections developed with others. The findings suggest that by engaging in various culturally meaningful activities, older Korean immigrants gain a sense of social, cultural, and psychological significance in life. This study also provided evidence that older Korean immigrants maintain and develop their cultural identity through culturally meaningful activities.

  17. Meaningful work and secondary school teachers' intention to leave

    OpenAIRE

    Janik, M.; Rothmann, S.

    2015-01-01

    The study investigates the relations between secondary school teachers' work-role fit, job enrichment, supervisor relationships, co-worker relationships, psychological meaningfulness of work and intention to leave. A cross-sectional survey was used. The participants were 502 secondary school teachers in Namibia. The following measuring instruments were used: Work-role Fit Scale, Job Enrichment Scale, Co-worker and Supervisor Relationships Scales, Psychological Meaningfulness Scale and Turnove...

  18. Design democratization with communities: Drawing toward locally meaningful design

    DEFF Research Database (Denmark)

    Winschiers-Goagoses, Naska; Winschiers-Theophilus, Heike; Rodil, Kasper

    2012-01-01

    The authors present community drawing as meaningful representations to inform locally valid technology design. They investigate recognition within and across cultural borders, thereby exposing variances of localities. The study contributes to the still scarce body of empirical work on culturally...... meaningful development of visual representations and recognition, as part of a longitudinal research project in which we co-design a 3D visualization for a specific Namibian pilot site....

  19. PROMOTING MEANINGFUL LEARNING THROUGH CREATE-SHARE-COLLABORATE

    OpenAIRE

    Sailin, Siti Nazuar; Mahmor, Noor Aida

    2017-01-01

    Students in this 21st century are required to acquire these 4C skills: Critical thinking, Communication, Collaboration and Creativity. These skills can be integrated in the teaching and learning through innovative teaching that promotes active and meaningful learning. One way of integrating these skills is through collaborative knowledge creation and sharing. This paper providesan example of meaningful teaching and learning activities designed within the Create-Share-Collaborate instructional...

  20. Self-Determination and Meaningful Work: Exploring Socioeconomic Constraints

    OpenAIRE

    Allan, Blake A.; Autin, Kelsey L.; Duffy, Ryan D.

    2016-01-01

    This study examined a model of meaningful work among a diverse sample of working adults. From the perspectives of Self-Determination Theory and the Psychology of Working Framework, we tested a structural model with social class and work volition predicting SDT motivation variables, which in turn predicted meaningful work. Partially supporting hypotheses, work volition was positively related to internal regulation and negatively related to amotivation, whereas social class was positively relat...

  1. Assessment of prognostic value of semiquantitative parameters on gated single photon emission computed tomography myocardial perfusion scintigraphy in a large middle eastern population

    International Nuclear Information System (INIS)

    Chavoshi, Maryam; Fard-Esfahani, Armaghan; Fallahi, Babak; Emami-Ardekani, Alireza; Beiki, Davood; Hassanzadeh-Rad, Arman; Eftekhari, Mohammad

    2005-01-01

    Coronary artery disease is the leading cause of mortality worldwide. The goal of this study is to determine the prognostic value of semiquantitative parameters of electrocardiogram-gated single photon emission computed tomography (SPECT) myocardial perfusion imaging (MPI) in a large Middle Eastern (Iranian) population. This study was a prospective study including all patients referred to our center for myocardial perfusion scan. The patients were followed annually up to 24 months and their survival information was collected. From 1148 patients, 473 (41.2%) men and 675 (58.8%) women, 40.6% had normal MPI, 13.3% near normal and 46.1% abnormal MPI. After follow-up of 929 patients, 97.4% of patients were alive, and 2.6% succumbed to cardiac deaths. Abnormal ejection fraction was related with cardiac events (P = 0.001), but neither transient ischemic dilation (TID) (P = 0.09) nor lung/heart ratio (P = 0.92) showed such relationship. Association between summed difference score (SDS) and soft cardiac events (P < 0.001) was significant. Summed motion score (SMS) and summed thickening score (STS) showed a significant relation with hard cardiac events, including myocardial infarction and cardiac death (P < 0.001 and P = 0.001, respectively). Totally, risk of all cardiac events was significantly higher in abnormal MPI group than normal group (P < 0.001, 0.02, and 0.025, respectively). No significant relationship was found between TID and total cardiac events (P = 0.478). Semiquantitative variables derived from gated SPECT MPI have independent prognostic value. Rate of total cardiac events is higher in patients with higher summed stress score and SDS. Total and hard cardiac events are higher in upper scores of functional parameters (SMS and STS). Total cardiac events are higher in patients with lower left ventricular ejection fraction

  2. Prognostic value of volumetric metabolic parameters measured by [18F]Fluorodeoxyglucose-positron emission tomography/computed tomography in patients with small cell lung cancer

    Science.gov (United States)

    2014-01-01

    Background We evaluated the prognostic value of volume-based metabolic positron emission tomography (PET) parameters in patients with small cell lung cancer (SCLC) compared with other factors. Methods The subjects were 202 patients with pathologically proven SCLC who underwent pretreatment 18F-fluorodeoxyglucose (FDG) PET/computed tomography (CT). Volumetric metabolic parameters of intrathoracic malignant hypermetabolic lesions, including maximum and average standardized uptake value, sum of metabolic tumor volume (MTV), and sum of total lesion glycolysis (TLG) were measured. Results 164 patients had died during follow-up (median 17.4 months) and median overall survival was 14 months. On univariate survival analysis, age, stage, treatment modality, sum of MTV (cutoff = 100 cm3), and sum of TLG (cutoff = 555) were significant predictors of survival. There was a very high correlation between the sum of MTV and the sum of TLG (r = 0.963, P < 0.001). On multivariate survival analysis, age (HR = 1.04, P < 0.001), stage (HR = 2.442, P < 0.001), and sum of MTV (HR = 1.662, P = 0.002) were independent prognostic factors. On subgroup analysis based on limited disease (LD) and extensive disease (ED), sum of MTV and sum of TLG were significant prognostic factors only in LD. Conclusion Both sum of MTV and sum of TLG of intrathoracic malignant hypermetabolic lesions are important independent prognostic factors for survival in patients with SCLC, in addition to age and clinical stage. However, it may be more useful in limited disease rather than in extensive disease. PMID:25609313

  3. Creating meaningful business continuity management programme metrics.

    Science.gov (United States)

    Strong, Brian

    2010-11-01

    The popular axiom, 'what gets measured gets done', is often applied in the quality management and continuous improvement disciplines. This truism is also useful to business continuity practitioners as they continually strive to prove the value of their organisation's investment in a business continuity management (BCM) programme. BCM practitioners must also remain relevant to their organisations as executives focus on the bottom line and maintaining stakeholder confidence. It seems that executives always find a way, whether in a hallway or elevator, to ask BCM professionals about the company's level of readiness. When asked, they must be ready with an informed response. The establishment of a process to measure business continuity programme performance and organisational readiness has emerged as a key component of US Department of Homeland Security 'Voluntary Private Sector Preparedness (PS-Prep) Program' standards where the overarching goal is to improve private sector preparedness for disasters and emergencies. The purpose of this paper is two-fold: to introduce continuity professionals to best practices that should be considered when developing a BCM metrics programme as well as providing a case study of how a large health insurance company researched, developed and implemented a process to measure BCM programme performance and company readiness.

  4. Predicting the local outcome of glottic squamous cell carcinoma after definitive radiation therapy: value of computed tomography-determined tumour parameters

    International Nuclear Information System (INIS)

    Hermans, R.; Van den Bogaert, W.; Rijnders, A.; Doornaert, P.; Baert, A.L.

    1999-01-01

    Background and purpose: The T-classification has shortcomings in the prediction of local outcome of glottic squamous cell carcinoma (SCC) treated by definitive radiation therapy. In this regard, the value of several CT-derived tumour parameters as predictors of local outcome was investigated. Materials and methods: The pretreatment CT studies of 119 patients with glottic SCC (T1, n=61; T2, n=40; T3, n=14; T4, n=4) treated with curative intent by radiation therapy were reviewed for tumoral involvement of specific laryngeal anatomic subsites (including laryngeal cartilages). Tumour volume was calculated with the summation-of-areas technique. Actuarial (life-table) statistical analysis was done for each of the covariates; multivariate analysis was performed using the Cox proportional hazards model.Results: In the actuarial analysis tumour volume was significantly correlated with local recurrence rate (P=0.0062). Involvement of the cricoid cartilage (P=0.0052), anterior commissure (P=0.0203), subglottis (P=0.0481) and preepiglottic space (P=0.0134) and degree of involvement of the true vocal cord (P=0.0441) and paraglottic space at the level of the true vocal cord (P=0.0002) were also significantly correlated with local recurrence rate. In the multivariate analysis, only degree of involvement of the paraglottic space (at the level of the true vocal cord) (P=0.0001) and preepiglottic space (P=0.02) were found to be independent predictors of local recurrence. The T-category was significantly correlated with local outcome in the actuarial analysis (P=0.0001), but not in the multivariate analysis (P=0.5915). Conclusions: Several CT-derived parameters are powerful predictors of local outcome in glottic cancer treated with radiation therapy; some of these parameters are stronger linked to the local control rate than the T-classification. (Copyright (c) 1999 Elsevier Science B.V., Amsterdam. All rights reserved.)

  5. Prognostic value of {sup 18}F-FDG PET/CT in patients with soft tissue sarcoma: comparisons between metabolic parameters

    Energy Technology Data Exchange (ETDEWEB)

    Hong, Sun-pyo [Sungkyunkwan University School of Medicine, Department of Nuclear Medicine, Samsung Medical Center, Seoul (Korea, Republic of); Lee, Seung Eun; Choi, Yoon-La [Sungkyunkwan University School of Medicine, Department of Pathology, Samsung Medical Center, Seoul (Korea, Republic of); Seo, Sung Wook; Sung, Ki-Sun [Sungkyunkwan University School of Medicine, Department of Orthopedic Surgery, Samsung Medical Center, Seoul (Korea, Republic of); Koo, Hong Hoe [Sungkyunkwan University School of Medicine, Department of Pediatrics, Samsung Medical Center, Seoul (Korea, Republic of); Choi, Joon Young [Sungkyunkwan University School of Medicine, Department of Nuclear Medicine, Samsung Medical Center, Seoul (Korea, Republic of)

    2014-05-15

    To investigate the relationship between volume-based PET parameters and prognosis in patients with soft tissue sarcoma (STS). We retrospectively reviewed 55 patients with pathologically proven STS who underwent pretreatment with {sup 18} F-Fluorodeoxyglucose ({sup 18}F-FDG) PET/CT. The maximum standardized uptake value (SUV{sub max}), average SUV (SUV{sub avg}), metabolic tumor volume (MTV), and total lesion glycolysis (TLG) of primary tumors were measured using a threshold SUV as liver activity for determining the boundary of tumors. Univariate and multivariate survival analyses for overall survival were performed according to the metabolic parameters and other clinical variables. Cancer-related death occurred in 19 of 55 patients (35 %) during the follow-up period (29 ± 23 months). On univariate analysis, AJCC stage (stage IV vs. I-III, hazard ratio (HR) = 2.837, p = 0.028), necrosis (G2 vs. G0-G1, HR = 3.890, p = 0.004), SUV{sub max} (1 unit - increase, HR = 1.146, p = 0.008), SUV{sub avg} (1 unit - increase, HR = 1.469, p = 0.032) and treatment modality (non-surgical therapy vs. surgery, HR = 4.467, p = 0.002) were significant predictors for overall survival. On multivariate analyses, SUV{sub max} (HR = 1.274, p = 0.015), treatment modality (HR = 3.353, p = 0.019) and necrosis (HR = 5.985, p = 0.006) were identified as significant independent prognostic factors associated with decreased overall survival. The SUV{sub max} of the primary tumor is a significant independent metabolic prognostic factor for overall survival in patients with STS. Volume-based PET parameters may not add prognostic information outside of the SUV{sub max}. (orig.)

  6. Helping others increases meaningful work: Evidence from three experiments.

    Science.gov (United States)

    Allan, Blake A; Duffy, Ryan D; Collisson, Brian

    2018-03-01

    The aim of the current research was to examine whether manipulating task significance increased the meaningfulness of work among students (Study 1), an online sample of working adults (Study 2), and public university employees (Study 3). In Study 1, students completed a typing task for the benefit of themselves, a charity, or someone they knew would directly benefit from their work. People who worked to benefit someone else, rather than themselves, reported greater task meaningfulness. In Study 2, a representative, online sample of employees reflected on a time when they worked to benefit themselves or someone else at work. Results revealed that people who reflected on working to benefit someone else, rather than themselves, reported greater work meaningfulness. In Study 3, public university employees participated in a community intervention by working as they normally would, finding new ways to help people each day, or finding several new ways to help others on a single day. People who helped others many times in a single day experienced greater gains in work meaningfulness over time. Across 3 experimental studies, we found that people who perceived their work as helping others experienced more meaningfulness in their work. This highlights the potential mechanisms practitioners, employers, and other parties can use to increase the meaningfulness of work, which has implications for workers' well-being and productivity. (PsycINFO Database Record (c) 2018 APA, all rights reserved).

  7. Meaningful work and mental health: job satisfaction as a moderator.

    Science.gov (United States)

    Allan, Blake A; Dexter, Chelsea; Kinsey, Rebecca; Parker, Shelby

    2018-02-01

    Depression, anxiety and stress are common problems for modern workers. Although having meaningful work, or work that is significant, facilitates personal growth, and contributes to the greater good, has been linked to better mental health, people's work might also need to be satisfying or enjoyable to improve outcomes. The purpose of the present study was to examine meaningful work's relation to mental health (i.e. depression, anxiety and stress) and investigate job satisfaction as a moderator of this relation. The study hypotheses were tested with a large, diverse sample recruited from an online source. Partially supporting hypotheses, when controlling for job satisfaction, meaningful work negatively correlated with depression but did not have a significant relation with anxiety and stress. Similarly, job satisfaction negatively predicted depression and stress. Furthermore, the relations between meaningful work and both anxiety and stress were moderated by job satisfaction. Specifically, only people perceiving their work as meaningful and satisfying reported less anxiety and stress. Although continued research is needed, employers and employees may have to target both the meaningfulness and job satisfaction to address the issues of stress and anxiety among working adults.

  8. Meaningful learning in business through serious games

    Directory of Open Access Journals (Sweden)

    Ana Cristina Urquidi Martín

    2017-10-01

    Full Text Available Purpose: The requirements of a business executive include the talent and creativity to solve problems and adapt to continuous changes presented by the economic and social environment. However, the university does not often prepare students in these skills. Businesses simulations are didactic tools in which participants assume a role and make decisions which affect the results of the company. This paper aims to provide empirical evidence on the effectiveness of business simulations in university teaching. Design/methodology/approach: We have implemented business simulations in a course in the College of Economics at the University of Valencia, during the 2015-2016 academic year. Questionnaires were used to collect the students’ opinions about this educational tool. Findings: Students are motivated and concentrated during all activities, which has promoted cooperation and/or competition. They therefore perceive these simulations as a useful tool to acquire skills, especially those linked to decision making, problem solving, and the analysis of business information. Research limitations/implications: No common theoretical framework exists in the literature for measuring the results of the learning. This study investigated the influence of three subjective variables. In this sense, future research could expand on the number of variables and include objective data. Practical implications: Improvement of the educational process. Social implications: Students receive a comprehensive education, including a set of social behaviors and cognitive, psychological and sensory skills, which enable them to respond successfully to new demands in the labor market. Originality/value: Much has been written about the usefulness of simulations in education, but there is little empirical evidence on the learning outcomes that result from their use.

  9. Algorithms to analyze the quality test parameter values of seafood in the proposed ontology based seafood quality analyzer and miner (ONTO SQAM model

    Directory of Open Access Journals (Sweden)

    Vinu Sherimon

    2017-07-01

    Full Text Available Ensuring the quality of food, particularly seafood has increasingly become an important issue nowadays. Quality Management Systems empower any organization to identify, measure, control and improve the quality of the products manufactured that will eventually lead to improved business performance. With the advent of new technologies, now intelligent systems are being developed. To ensure the quality of seafood, an ontology based seafood quality analyzer and miner (ONTO SQAM model is proposed. The knowledge is represented using ontology. The domain concepts are defined using ontology. This paper presents the initial part of the proposed model – the analysis of quality test parameter values. Two algorithms are proposed to do the analysis – Comparison Algorithm and Data Store Updater algorithm. The algorithms ensure that the values of various quality tests are in the acceptable range. The real data sets taken from different seafood companies in Kerala, India, and validated by the Marine Product Export Development Authority of India (MPEDA are used for the experiments. The performance of the algorithms is evaluated using standard performance metrics such as precision, recall, and accuracy. The results obtained show that all the three measures achieved good results.

  10. Normal value of functional parameters in gated myocardial perfusion SPECT in patients with low risk of coronary artery disease: emory cardiac tool box program

    Energy Technology Data Exchange (ETDEWEB)

    Kang, D. Y.; Kim, M. H.; Kim, Y. D.; Kim, D. K. [Donga University College of Medicine, Busan (Korea, Republic of)

    2002-07-01

    Absolute value of the functional data of gated myocardial perfusion SPECT is necessary to determine that individual patient is normal or not. Tc-99m MIBI gated myocardial perfusion SPECT was performed using emory cardiac tool box program. All patients (M:F=15:36, age 64{+-}10 yrs) showed normal myocardial perfusion. The patients with following characteristics were excluded; previous angina or MI, ECG change with Q wave or ST-T change, diabetes mellitus, hypercholesterolemia, typical chest pain and hypertension. In all patients, myocardial mass is 117{+-}23 g in stress gated SPECT, 106{+-}22 g in stress ungated SPECT and 102{+-}21 g in rest ungated SPECT. EDV is 90{+-}28 ml, ESV 26{+-}20 ml, SV 66{+-}21 ml, EF 73{+-}10 % and TID 1.06{+-}0.14. Myocardial mass in rest ungated SPECT is significantly different between men and women (p=0.025). Myocardial mass is significantly different between stress gated SPECT and stress ungated SPECT (p=0.000), and between stress ungated SPECT and rest ungated SPECT (p=0.003). We provide normal value of functional parameters to determine the abnormality of individual patients in patients with low risk of coronary artery disease.

  11. Knowledge construction in the classroom: a meaningful pedagogical dialogue

    Directory of Open Access Journals (Sweden)

    Jesuína Lopes de Almeida Pacca

    2015-12-01

    Full Text Available Teacher’s performance at their real classroom was analyzed in regard to the applied pedagogical interaction. These teachers were participating in a long range continuous formation course that uses the strategy of analyzing pedagogical planning while it was being elaborated , applied and continuously evaluated by the teacher; the course aimed to the construction of professional competence with an adequate sight of the classroom interaction, within constructivist parameters. The teacher pedagogical planning was the study object: it was discussed continuously by the peers group and the coordinator who intended to point out to the explicit pedagogical content and to the content objectives that were declared for every class plan. The learning objectives and the procedures contained within it were confronted with the real evidence of learning. In these discussions learning concepts that were coherent with constructivism were invoked in addition to science contents and their nature. Dialogue was important in these discussions and stressed as a means for teaching and continuous evaluation. In this dynamical process, the teacher planning was being constantly redrafted, changing the adjustment of that classroom students to the planned knowledge acquisition. This course dynamics, led by the coordinator, intended to be reproduced by participants with their students, at least in part. We noticed surprising results in these teachers professional development besides those that were concretely planned: the transference of the course procedures to the classroom seems to happen in regard to the presence of dialogue but the most meaningful part was individual and particular progress that was included in the development of their classes and led to an improvement of abilities. We concluded that unexpected results can be converted into poles of professional performance growth and performance evolution . These results have led us to give special importance to the

  12. Risk factor meta-analysis and Bayesian estimation of genetic parameters and breeding values for hypersensibility to cutaneous habronematidosis in donkeys.

    Science.gov (United States)

    Navas González, Francisco Javier; Jordana Vidal, Jordi; Camacho Vallejo, María Esperanza; León Jurado, Jose Manuel; de la Haba Giraldo, Manuel Rafael; Barba Capote, Cecilio; Delgado Bermejo, Juan Vicente

    2018-03-15

    Cutaneous habronematidosis (CH) is a highly prevalent seasonally recurrent skin disease that affects donkeys as a result from the action of spirurid stomach worm larvae. Carrier flies mistakenly deposit these larvae on previous skin lesions or on the moisture of natural orifices, causing distress and inflicting relapsing wounds to the animals. First, we carried out a meta-analysis of the predisposing factors that could condition the development of CH in Andalusian donkeys. Second, basing on the empirical existence of an inter and intrafamilial variation previously addressed by owners, we isolated the genetic background behind the hypersensibility to this parasitological disease. To this aim, we designed a Bayesian linear model (BLM) to estimate the breeding values and genetic parameters for the hypersensibility to CH as a way to infer the potential selection suitability of this trait, seeking the improvement of donkey conservation programs. We studied the historical record of the cases of CH of 765 donkeys from 1984 to 2017. Fixed effects included birth year, birth season, sex, farm/owner, and husbandry system. Age was included as a linear and quadratic covariate. Although the effects of birth season and birth year were statistically non-significant (P > 0.05), their respective interactions with sex and farm/owner were statistically significant (P < 0.01), what translated into an increase of 40.5% in the specificity and of 0.6% of the sensibility of the model designed, when such interactions were included. Our BLM reported highly accurate genetic parameters as suggested by the low error of around 0.005, and the 95% credible interval for the heritability of ±0.0012. The CH hypersensibility heritability was 0.0346. The value of 0.1232 for additive genetic variance addresses a relatively low genetic variation in the Andalusian donkey breed. Our results suggest that farms managed under extensive husbandry conditions are the most protective ones against

  13. Prognostic value of volumetric parameters of {sup 18}F-FDG PET in non-small-cell lung cancer: a meta-analysis

    Energy Technology Data Exchange (ETDEWEB)

    Im, Hyung-Jun [Seoul National University Hospital, Department of Nuclear Medicine, 101 Daehak-ro, Jongno-gu, Seoul (Korea, Republic of); Graduate School of Convergence Science and Technology, and College of Medicine or College of Pharmacy, Department of Molecular Medicine and Biopharmaceutical Sciences, Seoul (Korea, Republic of); Pak, Kyoungjune [Seoul National University Hospital, Department of Nuclear Medicine, 101 Daehak-ro, Jongno-gu, Seoul (Korea, Republic of); Pusan National University Hospital, Department of Nuclear Medicine and Biomedical Research Institute, Busan (Korea, Republic of); Cheon, Gi Jeong; Kang, Keon Wook; Chung, June-Key [Seoul National University Hospital, Department of Nuclear Medicine, 101 Daehak-ro, Jongno-gu, Seoul (Korea, Republic of); Seoul National University Hospital, Cancer Research Institute, Seoul (Korea, Republic of); Kim, Seong-Jang; Kim, In-Joo [Pusan National University Hospital, Department of Nuclear Medicine and Biomedical Research Institute, Busan (Korea, Republic of); Kim, E.E. [Graduate School of Convergence Science and Technology, and College of Medicine or College of Pharmacy, Department of Molecular Medicine and Biopharmaceutical Sciences, Seoul (Korea, Republic of); University of California at Irvine, Department of Radiological Science, California, CA (United States); Lee, Dong Soo [Seoul National University Hospital, Department of Nuclear Medicine, 101 Daehak-ro, Jongno-gu, Seoul (Korea, Republic of); Graduate School of Convergence Science and Technology, and College of Medicine or College of Pharmacy, Department of Molecular Medicine and Biopharmaceutical Sciences, Seoul (Korea, Republic of); Seoul National University Hospital, Cancer Research Institute, Seoul (Korea, Republic of)

    2014-09-06

    We conducted a comprehensive systematic review of the literature on volumetric parameters from {sup 18}F-FDG PET and a meta-analysis of the prognostic value of metabolic tumour volume (MTV) and total lesion glycolysis (TLG) in patients with lung cancer. A systematic search of MEDLINE and EMBASE was performed using the keywords ''positron emission tomography (PET)'', ''lung cancer'', and ''volume''. Inclusion criteria were: {sup 18}F-FDG PET used as an initial imaging tool; studies limited to non-small-cell lung cancer (NSCLC); volume measurement of lung cancer; patients who had not undergone surgery, chemotherapy, or radiotherapy before the PET scan; and studies that reported survival data. Event-free survival and overall survival were evaluated as outcomes. The impact of MTV and TLG on survival was measured in terms of the hazard ratio (HR) effect size. Data from each study were analysed using Review Manager 5.2. Thirteen eligible studies including 1,581 patients were analysed. Patients with high MTV showed a worse prognosis with an HR of 2.71 (95 % CI 1.82 - 4.02, p < 0.00001) for adverse events and an HR of 2.31 (95 % CI 1.54 - 3.47, p < 0.00001) for death. Patients with high TLG also showed a worse prognosis with an HR of 2.35 (95 % CI 1.91 - 2.89, p < 0.00001) for adverse events and an HR of 2.43 (95 % CI 1.89 - 3.11, p < 0.00001) for death. The prognostic value of MTV and TLG remained significant in a subgroup analysis according to TNM stage as well as the methods for defining cut-off values and tumour delineation. Volumetric parameters from {sup 18}F-FDG PET are significant prognostic factors for outcome in patients with NSCLC. Patients with a high MTV or TLG are at higher risk of adverse events and death. MTV and TLG were significant prognostic factors in patients with TNM stage I/II and stage III/IV NSCLC. (orig.)

  14. Prognostic value of metabolic parameters and clinical impact of {sup 18}F-fluorocholine PET/CT in biochemical recurrent prostate cancer

    Energy Technology Data Exchange (ETDEWEB)

    Colombie, M.; Bailly, C.; Rusu, D.; Rousseau, N. [Institut de Cancerologie de l' Ouest Rene Gauducheau, Nuclear Medicine, 44805 Nantes-St Herblain Cedex (France); Campion, L. [ICO Cancer Center, Statistics, Saint-Herblain (France); Nantes University, Nantes-Angers Cancer Research Center, INSERM U892-CNRS UMR 6299, Nantes (France); Rousseau, T. [Urologic Clinic Nantes-Atlantis, Saint Herblain (France); Mathieu, C. [University Hospital, Nuclear Medicine, Nantes (France); Ferrer, L. [ICO Cancer Center, Physics, Saint-Herblain (France); Kraeber-Bodere, F. [Institut de Cancerologie de l' Ouest Rene Gauducheau, Nuclear Medicine, 44805 Nantes-St Herblain Cedex (France); University Hospital, Nuclear Medicine, Nantes (France); Nantes University, Nantes-Angers Cancer Research Center, INSERM U892-CNRS UMR 6299, Nantes (France); Rousseau, C. [Institut de Cancerologie de l' Ouest Rene Gauducheau, Nuclear Medicine, 44805 Nantes-St Herblain Cedex (France); Nantes University, Nantes-Angers Cancer Research Center, INSERM U892-CNRS UMR 6299, Nantes (France)

    2015-11-15

    To evaluate the therapeutic impact of {sup 18}F-fluorocholine (FCH) PET/CT in biochemical recurrent prostate cancer (PC) and to investigate the value of quantitative FCH PET/CT parameters in predicting progression-free survival (PFS). This retrospective study included 172 consecutive patients with PC who underwent FCH PET/CT for biochemical recurrence. Mean rising PSA was 10.7 ± 35.0 ng/ml. Patients with positive FCH PET were classified into three groups: those with uptake only in the prostatic bed, those with locoregional disease, and those with distant metastases. Referring physicians were asked to indicate the hypothetical therapeutic strategy with and without the FCH PET/CT results. Clinical variables and PET parameters including SUVmax, SUVpeak, SUVmean, total lesion choline kinase activity (TLCKA) and standardized added metabolic activity (SAM) were recorded and a multivariate analysis was performed to determine the factors independently predicting PFS. In 137 of the 172 patients, the FCH PET/CT scan was positive, and of these, 29.9 % (41/137) had prostatic recurrence, 42.3 % (58/137) had pelvic lymph node recurrence with or without prostatic recurrence, and 27.7 % (38/137) had distant metastases. The FCH PET/CT result led to a change in treatment plan in 43.6 % (75/172) of the 172 patients. Treatment was changed in 49.6 % (68/137) of those with a positive FCH PET/CT scan and in 20 % (7/35) of those with a negative FCH PET/CT scan. After a median follow-up of 29.3 months (95 % CI 18.9 - 45.9 months), according to multivariate analysis age <70 years, SAM ≥23 and SUVmean ≥3 were parameters independently predicting PFS. A nomogram constructed using the three parameters showed 49 months of PFS in patients with the best scores (0 or 1) and only 11 months in patients with a poor score (score 3). This study indicates that a positive FCH PET result in PC patients with biochemical recurrence predicts a shorter PFS and confirms the major impact of the FCH PET

  15. Predictive value of modeled AUC(AFP-hCG), a dynamic kinetic parameter characterizing serum tumor marker decline in patients with nonseminomatous germ cell tumor.

    Science.gov (United States)

    You, Benoit; Fronton, Ludivine; Boyle, Helen; Droz, Jean-Pierre; Girard, Pascal; Tranchand, Brigitte; Ribba, Benjamin; Tod, Michel; Chabaud, Sylvie; Coquelin, Henri; Fléchon, Aude

    2010-08-01

    The early decline profile of alpha-fetoprotein (AFP) and human chorionic gonadotropin (hCG) in patients with nonseminomatous germ cell tumors (NSGCT) treated with chemotherapy may be related to the risk of relapse. We assessed the predictive values of areas under the curve of hCG (AUC(hCG)) and AFP (AUC(AFP)) of modeled concentration-time equations on progression-free survival (PFS). Single-center retrospective analysis of hCG and AFP time-points from 65 patients with IGCCCG intermediate-poor risk NSGCT treated with 4 cycles of bleomycin-etoposide-cisplatin (BEP). To determine AUC(hCG) and AUC(AFP) for D0-D42, AUCs for D0-D7 were calculated using the trapezoid rule and AUCs for D7-D42 were calculated using the mathematic integrals of equations modeled with NONMEM. Combining AUC(AFP) and AUC(hCG) enabled us to define 2 predictive groups: namely, patients with favorable and unfavorable AUC(AFP-hCG). Survival analyses and ROC curves assessed the predictive values of AUC(AFP-hCG) groups regarding progression-free survival (PFS) and compared them with those of half-life (HL) and time-to-normalization (TTN). Mono-exponential models best fit the patterns of marker decreases. Patients with a favorable AUC(AFP-hCG) had a significantly better PFS (100% vs 71.5%, P = .014). ROC curves confirmed the encouraging predictive accuracy of AUC(AFP-hCG) against HL or TTN regarding progression risk (ROC AUCs = 79.6 vs 71.9 and 70.2 respectively). Because of the large number of patients with missing data, multivariate analysis could not be performed. AUC(AFP-hCG) is a dynamic parameter characterizing tumor marker decline in patients with NSGCT during BEP treatment. Its value as a promising predictive factor should be validated. Copyright 2010 Elsevier Inc. All rights reserved.

  16. Meaningful real-life relationships in massively multiplayer online roleplaying games

    OpenAIRE

    Mansikkamäki, E. (Eetu)

    2014-01-01

    Abstract Massively Multiplayer Online Roleplaying Games are extremely popular with millions and millions of players spending large portions of their free time in these virtual environments. Still the social value and the meaningfulness of the relationships formed within them are questioned by most non-gamers and even some gamers. In the past even academia was mainly concentrating on the negative aspects of gaming but lately...

  17. Effect of process parameters on energy performance of spray drying with exhaust air heat recovery for production of high value particles

    International Nuclear Information System (INIS)

    Julklang, Wittaya; Golman, Boris

    2015-01-01

    Highlights: • We study heat recovery from spray dryer using air-to-air heat exchanger. • We examine dryer energy performance using advanced mathematical model. • We use the response surface methodology to study the effect of process parameters. • Energy efficiency up to 43.3% is obtained at high flow rate of dilute slurry. • Energy saving up to 52.4% is obtained at high drying air temperature. - Abstract: Spray drying process has been widely used in various industries for many decades for production of numerous materials. This paper explores the energy performance of an industrial scale spray dryer equipped with an exhaust air heat recovery system for production of high value particles. Energy efficiency and energy saving were calculated using a comprehensive mathematical model of spray drying. The response surface methodology (RSM) was utilized to study the effect of process parameters on energy performance using a space-filling design. The meta model equations were formulated employing the well-fitted response surface equations with adjusted R 2 larger than 0.995. The energy efficiency as high as 43.3% was obtained at high flow rate of dilute slurry, while the highest energy saving of 52.4% was found by combination of positive effect of drying air temperature and negative effect of slurry mass flow rate. The utilization of efficient air-to-air heat exchanger leads to an increase in energy efficiency and energy savings. The detailed temperature and vapor concentration profiles obtained with the model are also valuable in determining final product quality when spray dryer is operated at energy efficient conditions

  18. Radiation quantum effects in condensed media with large of De Boer parameter values; Radiatsionnye kvantovye ehffekty v kondensirovannykh sredakh, obuslovlennye bol`shoj velichinoj parametra De Bura

    Energy Technology Data Exchange (ETDEWEB)

    Turaeva, N N

    1994-12-31

    This work deals with the role of large values of De Boer parameter and Onzager radius in radiation quantum effects. Taking into account quantum annealing probability which can be calculated on the basis of Chapmen-Kholmogorov equation in approach of nearest neighbours, the expression for cross section of over threshold defect production was obtained. The quantum theory of Staebler-Wronsky effect in a-Si:H was constructed taking into account the existence of photon absorption by Si-H bond and simultaneous hydrogen atom displacement. Low temperature ionization stimulated effects in Si and Ge in the case of electron irradiation were investigated. It was shown that De Boer parameter increase during its interaction with electron excitations made defects to be quantum objects(within the limit as quasiparticle - inverson). Watkins effect kinetics was constructed and it was shown that experimental dependence of vacancy production rate along doping acceptors` concentration can`t be obtained on the basis of previous concepts. The model of low temperature radiation effects in Ge doped by V group impurities was constructed. It was shown that account of self-interstitial atom quantum diffusion with length scale hierarchy of all acting fields( where Onzager radius is the largest one ) allows to eliminate the contradiction between Borgoin-Mollot and Klontz-Mackey results. The mechanism of intensification of dislocation bends tunneling due to electron excitation auto localization on them was proposed. The thermal dependence of this effect was investigated and possibility of this effect manifestation in A{sub 2}B{sub 6} semiconductors under photo-, X- and {gamma}- irradiation was suggested.

  19. Prognostic value of pretreatment volume-based quantitative {sup 18}F-FDG PET/CT parameters in patients with malignant pleural mesothelioma

    Energy Technology Data Exchange (ETDEWEB)

    Kitajima, Kazuhiro, E-mail: kitajima@med.kobe-u.ac.jp [Division of Nuclear Medicine and PET Center, Department of Radiology, Hyogo College of Medicine, Hyogo (Japan); Doi, Hiroshi, E-mail: h-doi@hyo-med.ac.jp [Department of Radiology, Hyogo College of Medicine, Hyogo (Japan); Kuribayashi, Kozo, E-mail: kuririn@hyo-med.ac.jp [Division of Respiratory Medicine, Department of Internal Medicine, Hyogo College of Medicine, Hyogo (Japan); Hashimoto, Masaki, E-mail: kogekogemasaki@gmail.com [Department of Thoracic Surgery, Hyogo College of Medicine, Hyogo (Japan); Tsuchitani, Tatsuya, E-mail: tty-823@hyo-med.ac.jp [Department of Radiological Technology, Hyogo College of Medicine College Hospital, Hyogo (Japan); Tanooka, Masao, E-mail: masao1108@gmail.com [Department of Radiological Technology, Hyogo College of Medicine College Hospital, Hyogo (Japan); Fukushima, Kazuhito, E-mail: fukuchan00106@gmail.com [Division of Nuclear Medicine and PET Center, Department of Radiology, Hyogo College of Medicine, Hyogo (Japan); Nakano, Takashi, E-mail: t-nakano@hyo-med.ac.jp [Division of Respiratory Medicine, Department of Internal Medicine, Hyogo College of Medicine, Hyogo (Japan); Hasegawa, Seiki, E-mail: hasegawa@hyo-med.ac.jp [Department of Thoracic Surgery, Hyogo College of Medicine, Hyogo (Japan); Hirota, Shozo, E-mail: hirota-s@hyo-med.ac.jp [Department of Radiology, Hyogo College of Medicine, Hyogo (Japan)

    2017-01-15

    Purpose: To investigate the relationships between pretreatment volume-based quantitative {sup 18}F-fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) parameters and overall survival (OS) in patients with malignant pleural mesothelioma (MPM). Materials and methods: We retrospectively reviewed data from 201 MPM patients, of whom 38 underwent surgical resection, and calculated the maximum standardized uptake value (SUVmax), metabolic tumor volume (MTV), and total lesion glycolysis (TLG), including primary tumors and nodal or distant metastatic lesions, on pretreatment {sup 18}F-FDG PET/CT. Relationships between clinicopathological factors (age, sex, performance status, European Organization for Research and Treatment of Cancer [EORTC] score, histological subtype, TNM stage, and treatment strategy), volume-based quantitative PET/CT parameters, and OS were evaluated using a Cox proportional hazards model and log-rank test. Results: The median follow-up was 15 months (range, 1–96 months; median, 17 months). In a univariate analysis of all patients, older age (p < 0.05), high EORTC score (p < 0.001), non-epithelioid histological subtype (p < 0.001), high T stage (p < 0.001), positive N/M status (p < 0.05, p < 0.001), advanced TNM stage (p < 0.001), non-surgical treatment (p < 0.001), and high SUVmax (p < 0.001), MTV (p < 0.001), or TLG (p < 0.001) were associated with significantly shorter OS. A multivariate analysis confirmed non-epithelioid subtype (hazard ratio [HR]: 1.69, 95% confidence interval [CI]: 1.14–2.48; p < 0.05), non-surgical treatment (HR: 0.58, 95% CI: 0.34–0.95; p < 0.05), and high TLG (HR: 1.97, 95% CI: 1.14–3.44; p < 0.05) as independent negative predictors. Conclusions: Pretreatment volume-based quantitative {sup 18}F-FDG PET/CT parameters, especially TLG, could serve as potential surrogate markers for MPM prognosis.

  20. Prognostic value of pretreatment volume-based quantitative 18F-FDG PET/CT parameters in patients with malignant pleural mesothelioma

    International Nuclear Information System (INIS)

    Kitajima, Kazuhiro; Doi, Hiroshi; Kuribayashi, Kozo; Hashimoto, Masaki; Tsuchitani, Tatsuya; Tanooka, Masao; Fukushima, Kazuhito; Nakano, Takashi; Hasegawa, Seiki; Hirota, Shozo

    2017-01-01

    Purpose: To investigate the relationships between pretreatment volume-based quantitative 18 F-fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) parameters and overall survival (OS) in patients with malignant pleural mesothelioma (MPM). Materials and methods: We retrospectively reviewed data from 201 MPM patients, of whom 38 underwent surgical resection, and calculated the maximum standardized uptake value (SUVmax), metabolic tumor volume (MTV), and total lesion glycolysis (TLG), including primary tumors and nodal or distant metastatic lesions, on pretreatment 18 F-FDG PET/CT. Relationships between clinicopathological factors (age, sex, performance status, European Organization for Research and Treatment of Cancer [EORTC] score, histological subtype, TNM stage, and treatment strategy), volume-based quantitative PET/CT parameters, and OS were evaluated using a Cox proportional hazards model and log-rank test. Results: The median follow-up was 15 months (range, 1–96 months; median, 17 months). In a univariate analysis of all patients, older age (p < 0.05), high EORTC score (p < 0.001), non-epithelioid histological subtype (p < 0.001), high T stage (p < 0.001), positive N/M status (p < 0.05, p < 0.001), advanced TNM stage (p < 0.001), non-surgical treatment (p < 0.001), and high SUVmax (p < 0.001), MTV (p < 0.001), or TLG (p < 0.001) were associated with significantly shorter OS. A multivariate analysis confirmed non-epithelioid subtype (hazard ratio [HR]: 1.69, 95% confidence interval [CI]: 1.14–2.48; p < 0.05), non-surgical treatment (HR: 0.58, 95% CI: 0.34–0.95; p < 0.05), and high TLG (HR: 1.97, 95% CI: 1.14–3.44; p < 0.05) as independent negative predictors. Conclusions: Pretreatment volume-based quantitative 18 F-FDG PET/CT parameters, especially TLG, could serve as potential surrogate markers for MPM prognosis.

  1. Finite-part integration of the generalized Stieltjes transform and its dominant asymptotic behavior for small values of the parameter. I. Integer orders

    Science.gov (United States)

    Tica, Christian D.; Galapon, Eric A.

    2018-02-01

    The paper addresses the exact evaluation of the generalized Stieltjes transform Sn[f ] =∫0∞f (x ) (ω+x ) -nd x of integral order n = 1, 2, 3, … about ω = 0 from which the asymptotic behavior of Sn[f] for small parameters ω is directly extracted. An attempt to evaluate the integral by expanding the integrand (ω + x)-n about ω = 0 and then naively integrating the resulting infinite series term by term leads to an infinite series whose terms are divergent integrals. Assigning values to the divergent integrals, say, by analytic continuation or by Hadamard's finite part is known to reproduce only some of the correct terms of the expansion but completely misses out a group of terms. Here we evaluate explicitly the generalized Stieltjes transform by means of finite-part integration recently introduced in Galapon [Proc. R. Soc. A 473, 20160567 (2017)]. It is shown that, when f(x) does not vanish or has zero of order m at the origin such that (n - m) ≥ 1, the dominant terms of Sn[f] as ω → 0 come from contributions arising from the poles and branch points of the complex valued function f(z)(ω + z)-n. These dominant terms are precisely the terms missed out by naive term by term integration. Furthermore, it is demonstrated how finite-part integration leads to new series representations of special functions by exploiting their known Stieltjes integral representations. Finally, the application of finite part integration in obtaining asymptotic expansions of the effective diffusivity in the limit of high Peclet number, the Green-Kubo formula for the self-diffusion coefficient, and the antisymmetric part of the diffusion tensor in the weak noise limit is discussed.

  2. MICROTOUGH - calculation of characteristic upper shelf fracture toughness values from microstructural parameters for high strength structural steels with normalized or quenched and tempered microstructure

    International Nuclear Information System (INIS)

    Muenstermann, S.; Dahl, W.; Langenberg, P.; Deimel, P.; Sattler, E.

    2004-01-01

    In modern applications, high strength steels are often utilised to increase the load bearing capacity of components. For safe design it is also necessary that these steels have an adequate fracture toughness. The mechanical properties of high strength structural steels are a result of the production process. In consequence, they are strongly related to the microstructure. Therefore, the aim of the research work in the Microtough project is to develop and apply a new method of quantitative correlation between microstructural parameters and characteristic fracture toughness values. This correlation will on the one hand help for the design of new structural steels with high toughness. On the other hand, it shall allow to characterise the fracture toughness of steel without performing expensive fracture mechanics tests. The research work is carried out in the full temperature range from lower to upper shelf. As both RWTH Aachen University and MPA Uni Stuttgart concentrate on ductile fracture behaviour in their research work, the focus of the presentation lies in the upper shelf. (orig.)

  3. Designing Meaningful Game Experiences for Rehabilitation and Sustainable Mobility Settings

    Directory of Open Access Journals (Sweden)

    Silvia Gabrielli

    2014-03-01

    Full Text Available This paper presents the approach followed in two ongoing research projects aimed to designing meaningful game-based experiences to support home rehabilitation, eco-sustainable mobility goals and more in general better daily lifestyles. We first introduce the need for designing meaningful game-based experiences that are well-connected to the relevant non-game settings and can be customized by/for users, then, we show examples of how this approach can be realized in the rehabilitation and sustainable mobility contexts.

  4. The prognostic value of baseline {sup 18}F-FDG PET/CT in steroid-naive large-vessel vasculitis: introduction of volume-based parameters

    Energy Technology Data Exchange (ETDEWEB)

    Dellavedova, L. [Ospedale Civile di Legnano, PET/CT Center - Nuclear Medicine Department, Legnano (Italy); University of Milan, Department of Health Sciences, Milan (Italy); Carletto, M.; Maffioli, L.S. [Ospedale Civile di Legnano, PET/CT Center - Nuclear Medicine Department, Legnano (Italy); Faggioli, P.; Sciascera, A.; Mazzone, A. [Ospedale Civile di Legnano, Internal Medicine Department, Legnano (Italy); Del Sole, A. [University of Milan, Department of Health Sciences, Milan (Italy)

    2016-02-15

    The aim of this study was to analyse if the result of a baseline {sup 18}F-fluorodeoxyglucose (FDG) positron emission tomography (PET)/CT scan, in large-vessel vasculitis (LVV) patients, is able to predict the course of the disease, not only in terms of presence/absence of final complications but also in terms of favourable/complicated progress (response to steroid therapy, time to steroid suspension, relapses, etc.). A total of 46 consecutive patients, who underwent {sup 18}F-FDG PET/CT between May 2010 and March 2013 for fever of unknown origin (FUO) or suspected vasculitis (before starting corticosteroid therapy), were enrolled. The diagnosis of LVV was confirmed in 17 patients. Considering follow-up results, positive LVV patients were divided into two groups, one characterized by favourable (nine) and the other by complicated progress (eight), on the basis of presence/absence of vascular complications, presence/absence of at least another positive PET/CT during follow-up and impossibility to comply with the tapering schedule of the steroid due to biochemical/symptomatic relapse. Vessel uptake in subjects of the two groups was compared in terms of intensity and extension. To evaluate the extent of active disease, we introduced two volume-based parameters: ''volume of increased uptake'' (VIU) and ''total lesion glycolysis'' (TLG). The threshold used to calculate VIU on vessel walls was obtained by the ''vessel to liver'' ratio by means of receiver-operating characteristic analysis and was set at 0.92 x liver maximum standardized uptake value in each patient. Measures of tracer uptake intensity were significantly higher in patients with complicated progress compared to those with a favourable one (p < 0.05). Measures of disease extension were even more significant and TLG emerged as the best parameter to separate the two groups of patients (p = 0.01). This pilot study shows that, in LVV patients, the

  5. The prognostic value of baseline 18F-FDG PET/CT in steroid-naive large-vessel vasculitis: introduction of volume-based parameters

    International Nuclear Information System (INIS)

    Dellavedova, L.; Carletto, M.; Maffioli, L.S.; Faggioli, P.; Sciascera, A.; Mazzone, A.; Del Sole, A.

    2016-01-01

    The aim of this study was to analyse if the result of a baseline 18 F-fluorodeoxyglucose (FDG) positron emission tomography (PET)/CT scan, in large-vessel vasculitis (LVV) patients, is able to predict the course of the disease, not only in terms of presence/absence of final complications but also in terms of favourable/complicated progress (response to steroid therapy, time to steroid suspension, relapses, etc.). A total of 46 consecutive patients, who underwent 18 F-FDG PET/CT between May 2010 and March 2013 for fever of unknown origin (FUO) or suspected vasculitis (before starting corticosteroid therapy), were enrolled. The diagnosis of LVV was confirmed in 17 patients. Considering follow-up results, positive LVV patients were divided into two groups, one characterized by favourable (nine) and the other by complicated progress (eight), on the basis of presence/absence of vascular complications, presence/absence of at least another positive PET/CT during follow-up and impossibility to comply with the tapering schedule of the steroid due to biochemical/symptomatic relapse. Vessel uptake in subjects of the two groups was compared in terms of intensity and extension. To evaluate the extent of active disease, we introduced two volume-based parameters: ''volume of increased uptake'' (VIU) and ''total lesion glycolysis'' (TLG). The threshold used to calculate VIU on vessel walls was obtained by the ''vessel to liver'' ratio by means of receiver-operating characteristic analysis and was set at 0.92 x liver maximum standardized uptake value in each patient. Measures of tracer uptake intensity were significantly higher in patients with complicated progress compared to those with a favourable one (p < 0.05). Measures of disease extension were even more significant and TLG emerged as the best parameter to separate the two groups of patients (p = 0.01). This pilot study shows that, in LVV patients, the combined

  6. Meaningful Work and Secondary School Teachers' Intention to Leave

    Science.gov (United States)

    Janik, M.; Rothmann, S.

    2015-01-01

    The study investigates the relations between secondary school teachers' work-role fit, job enrichment, supervisor relationships, co-worker relationships, psychological meaningfulness of work and intention to leave. A cross-sectional survey was used. The participants were 502 secondary school teachers in Namibia. The following measuring instruments…

  7. Meaningful community involvement in protected area issues: a dialogue session

    Science.gov (United States)

    Laurie Yung

    2000-01-01

    The current effort to rethink public involvement in decision-making processes for federal lands is gaining momentum. Advocates of alternative decision-making processes seek to involve communities in more meaningful ways than traditional NEPA-style public participation. These new processes take the form of citizen monitoring, partnerships, and most often, collaboration...

  8. Pedagogical Principles of Learning to Teach Meaningful Physical Education

    Science.gov (United States)

    Ní Chróinín, Déirdre; Fletcher, Tim; O'Sullivan, Mary

    2018-01-01

    Background: Concerns that current forms of physical education teacher education (PETE) are not adequately providing teachers with the tools necessary for working with the realities and challenges of teaching physical education in contemporary schools has led some scholars to advocate for an approach that prioritises meaningfulness in physical…

  9. Callings, work role fit, psychological meaningfulness and work ...

    African Journals Online (AJOL)

    Our aim in this study was to investigate the relationships among a calling orientation, work role fit, psychological meaningfulness and work engagement of teachers in Zambia. A quantitative approach was followed and a cross-sectional survey was used. The sample (n = 150) included 75 basic and 75 secondary school ...

  10. Morality and a Meaningful Life | Thomas | Philosophical Papers

    African Journals Online (AJOL)

    ... healthy dovetail with respect to leading a meaningful life. With this argument regarding psychological health I draw upon, and extend, P. F. Strawson's seminal essay “Freedom and Resentment”. Also in this regard, I extend Wittgenstein's argument against the possibility of a private language to social behavior generally.

  11. Water Habitat Study: Prediction Makes It More Meaningful.

    Science.gov (United States)

    Glasgow, Dennis R.

    1982-01-01

    Suggests a teaching strategy for water habitat studies to help students make a meaningful connection between physiochemical data (dissolved oxygen content, pH, and water temperature) and biological specimens they collect. Involves constructing a poster and using it to make predictions. Provides sample poster. (DC)

  12. Cultural study in design : In search of a meaningful approach

    NARCIS (Netherlands)

    van Boeijen, A.G.C.

    2014-01-01

    Does the Circuit of Culture help design students to do a cultural study that is meaningful for their design project? Indeed, it provides a good view on the phenomenon culture, its complexity and how contemporary cultures can be studied, providing an overview and structure of the processes that

  13. Meaningful Gamification in an Industrial/Organizational Psychology Course

    Science.gov (United States)

    Stansbury, Jessica A.; Earnest, David R.

    2017-01-01

    Motivation and game research continue to demonstrate that the implementation of game design characteristics in the classroom can be engaging and intrinsically motivating. The present study assessed the extent to which an industrial organizational psychology course designed learning environment created with meaningful gamification elements can…

  14. Using Meaningful Contexts to Promote Understanding of Pronumerals

    Science.gov (United States)

    Linsell, Chris; Cavanagh, Michael; Tahir, Salma

    2013-01-01

    Developing a conceptual understanding of elementary algebra has been the focus of a number of recent articles in this journal. Baroudi (2006) advocated problem solving to assist students' transition from arithmetic to algebra, and Shield (2008) described the use of meaningful contexts for developing the concept of function. Samson (2011, 2012)…

  15. Comprehension for What? Preparing Students for Their Meaningful Future

    Science.gov (United States)

    Conley, Mark W.; Wise, Antoinette

    2011-01-01

    Researchers, policymakers, and educators face a daunting task these days concerning literacy education for the here and now and literacy for the future. Even though one clings to the romantic notion that education provides the building blocks in a straight line to a meaningful future, the reality is that mixed goals and instructional messages…

  16. Operating Room Delays: Meaningful Use in Electronic Health Record.

    Science.gov (United States)

    Van Winkle, Rachelle A; Champagne, Mary T; Gilman-Mays, Meri; Aucoin, Julia

    2016-06-01

    Perioperative areas are the most costly to operate and account for more than 40% of expenses. The high costs prompted one organization to analyze surgical delays through a retrospective review of their new electronic health record. Electronic health records have made it easier to access and aggregate clinical data; 2123 operating room cases were analyzed. Implementing a new electronic health record system is complex; inaccurate data and poor implementation can introduce new problems. Validating the electronic health record development processes determines the ease of use and the user interface, specifically related to user compliance with the intent of the electronic health record development. The revalidation process after implementation determines if the intent of the design was fulfilled and data can be meaningfully used. In this organization, the data fields completed through automation provided quantifiable, meaningful data. However, data fields completed by staff that required subjective decision making resulted in incomplete data nearly 24% of the time. The ease of use was further complicated by 490 permutations (combinations of delay types and reasons) that were built into the electronic health record. Operating room delay themes emerged notwithstanding the significant complexity of the electronic health record build; however, improved accuracy could improve meaningful data collection and a more accurate root cause analysis of operating room delays. Accurate and meaningful use of data affords a more reliable approach in quality, safety, and cost-effective initiatives.

  17. Synonyms, Antonyms, and Retroactive Inhibition with Meaningful Material

    Science.gov (United States)

    Weisshed, Ethel

    1973-01-01

    The determination of the extent to which generalizations derived from studies of rote verbal learning, particularly paired-associate learning applied to highly meaningful materials, was the focus of this study. It was found that discriminating tags to synonyms and antonyms permitting the application of appropriate transfer rules may be attached.…

  18. How Do Novice Art Teachers Define and Implement Meaningful Curriculum?

    Science.gov (United States)

    Bain, Christina; Newton, Connie; Kuster, Deborah; Milbrandt, Melody

    2010-01-01

    Four researchers collaborated on this qualitative case study that examined 11 first-year novice art teachers' understanding and implementation of meaningful curriculum. Participants were selected through a criterion method sampling strategy; the subjects were employed in rural, urban, and suburban public school districts. In order to conduct a…

  19. Authentic Leadership and Altruism: The Mediating Role of Meaningfulness

    Science.gov (United States)

    Sagnak, Mesut; Kuruöz, Mehmet

    2017-01-01

    The purpose of this study was to investigate the mediating effects of meaningfulness on the relationship between authentic leadership and altruistic behavior. The participants consisted of 356 teachers randomly selected from 14 primary and secondary schools in Nigde. Three different instruments were used in this study. The scales were translated…

  20. Modeling Meaningful Learning in Chemistry Using Structural Equation Modeling

    Science.gov (United States)

    Brandriet, Alexandra R.; Ward, Rose Marie; Bretz, Stacey Lowery

    2013-01-01

    Ausubel and Novak's construct of "meaningful learning" stipulates that substantive connections between new knowledge and what is already known requires the integration of thinking, feeling, and performance (Novak J. D., (2010), "Learning, creating, and using knowledge: concept maps as facilitative tools in schools and…

  1. Identifying the connective strength between model parameters and performance criteria

    Directory of Open Access Journals (Sweden)

    B. Guse

    2017-11-01

    Full Text Available In hydrological models, parameters are used to represent the time-invariant characteristics of catchments and to capture different aspects of hydrological response. Hence, model parameters need to be identified based on their role in controlling the hydrological behaviour. For the identification of meaningful parameter values, multiple and complementary performance criteria are used that compare modelled and measured discharge time series. The reliability of the identification of hydrologically meaningful model parameter values depends on how distinctly a model parameter can be assigned to one of the performance criteria. To investigate this, we introduce the new concept of connective strength between model parameters and performance criteria. The connective strength assesses the intensity in the interrelationship between model parameters and performance criteria in a bijective way. In our analysis of connective strength, model simulations are carried out based on a latin hypercube sampling. Ten performance criteria including Nash–Sutcliffe efficiency (NSE, Kling–Gupta efficiency (KGE and its three components (alpha, beta and r as well as RSR (the ratio of the root mean square error to the standard deviation for different segments of the flow duration curve (FDC are calculated. With a joint analysis of two regression tree (RT approaches, we derive how a model parameter is connected to different performance criteria. At first, RTs are constructed using each performance criterion as the target variable to detect the most relevant model parameters for each performance criterion. Secondly, RTs are constructed using each parameter as the target variable to detect which performance criteria are impacted by changes in the values of one distinct model parameter. Based on this, appropriate performance criteria are identified for each model parameter. In this study, a high bijective connective strength between model parameters and performance criteria

  2. Meaningfulness in work - experiences among employed individuals with persistent mental illness.

    Science.gov (United States)

    Leufstadius, Christel; Eklund, Mona; Erlandsson, Lena-Karin

    2009-01-01

    The aim of the present study was to investigate how people with persistent mental illness, with various types of work and employment conditions, experience and describe the meaningfulness of work. The study had a qualitative approach and twelve informants living in the community were purposefully selected and interviewed according to overarching themes. The interviews were analysed using qualitative content analysis, and all of the authors were involved in the analysis process. The findings resulted in four main themes: 1) work per se has certain characteristics, 2) participation in different contexts gives a feeling of normality, acceptance, belonging and fulfilment of norms and values, 3) work affords structure, energy and a balanced daily life, and 4) work increases well-being and strengthens one's identity. A tentative model is described concerning perceived meaningfulness in work among individuals with persistent mental illness, in which the first three aspects of meaning are a prerequisite for meaning in terms of increased well-being and strengthened identity. Furthermore, it seems important that work has to bring the just right challenge to the individual in order for him or her to perceive the identified aspects of meaningfulness.

  3. An empirically based conceptual framework for fostering meaningful patient engagement in research.

    Science.gov (United States)

    Hamilton, Clayon B; Hoens, Alison M; Backman, Catherine L; McKinnon, Annette M; McQuitty, Shanon; English, Kelly; Li, Linda C

    2018-02-01

    Patient engagement in research (PEIR) is promoted to improve the relevance and quality of health research, but has little conceptualization derived from empirical data. To address this issue, we sought to develop an empirically based conceptual framework for meaningful PEIR founded on a patient perspective. We conducted a qualitative secondary analysis of in-depth interviews with 18 patient research partners from a research centre-affiliated patient advisory board. Data analysis involved three phases: identifying the themes, developing a framework and confirming the framework. We coded and organized the data, and abstracted, illustrated, described and explored the emergent themes using thematic analysis. Directed content analysis was conducted to derive concepts from 18 publications related to PEIR to supplement, confirm or refute, and extend the emergent conceptual framework. The framework was reviewed by four patient research partners on our research team. Participants' experiences of working with researchers were generally positive. Eight themes emerged: procedural requirements, convenience, contributions, support, team interaction, research environment, feel valued and benefits. These themes were interconnected and formed a conceptual framework to explain the phenomenon of meaningful PEIR from a patient perspective. This framework, the PEIR Framework, was endorsed by the patient research partners on our team. The PEIR Framework provides guidance on aspects of PEIR to address for meaningful PEIR. It could be particularly useful when patient-researcher partnerships are led by researchers with little experience of engaging patients in research. © 2017 The Authors Health Expectations Published by John Wiley & Sons Ltd.

  4. Factor Analysis, AMMI Stability Value (ASV Parameter and GGE Bi-Plot Graphical Method of Quantitative and Qualitative Traits in Potato Genotypes

    Directory of Open Access Journals (Sweden)

    Davood Hassanpanah

    2016-10-01

    Full Text Available Quantitative and qualitative traits and stability of marketable tuber yield of 14 promising potato clones, along with three commercial cultivars (Agria, Marfona and Savalan as checks, were evaluated at the Ardabil Agricultural and Natural Resources Research Station during 2013 and 2014. The experiment was based on a randomized complete block design with four replications. During growing period and after harvest, traits like main stem number per plant, plant height, tuber number and weight per plant, total and marketable tuber yield, dry matter percentage, baking type, hollow heart, tuber inner ring and discoloration of raw tuber flesh after 24 hours were measured. Combined ANONA for quantitative traits showed that there were significant differences among promising clones as to total and marketable tuber yield, tuber number and weight per plant, plant height, tuber mean weight, main stem number per plant and dry matter percentage and their interactions with year in total and marketable tuber yield. The clone 9 (397078-3 with the least amount of marketable tuber yield had significant difference with clones 4 (397045-13, 1 (397031-16, 3 (397031-11, 6 (397009-8 and 12 (397067-6 in 2013 and with clone 4 (397045-13 and Agria cultivar in 2014. The clones 4(397045-13, 1 (397031-16 and 12 (397067-6 had uniform tuber, yellow to dark-yellow skin and light-yellow to yellow flesh color, tuber shape of oval round and round, shallow to mid shallow eyes, no tuber inner ring, hollow heart and tuber inner crack and mid-late maturity. They were selected for home consumption of chips, french-fries and frying. Based on the results of factor analysis, "tuber yield", "number of tuber" and "plant structural and quality "were named as first, second and third quality determining factors respectively. In this experiment, GGE Bi-plot model and AMMI Stability Value (ASV parameter, were acceptable methods for the selection of marketable tuber yield stability which found to

  5. In search of meaningfulness: nostalgia as an antidote to boredom.

    Science.gov (United States)

    van Tilburg, Wijnand A P; Igou, Eric R; Sedikides, Constantine

    2013-06-01

    We formulated, tested, and supported, in 6 studies, a theoretical model according to which individuals use nostalgia as a way to reinject meaningfulness in their lives when they experience boredom. Studies 1-3 established that induced boredom causes increases in nostalgia when participants have the opportunity to revert to their past. Studies 4 and 5 examined search for meaning as a mediator of the effect of boredom on nostalgia. Specifically, Study 4 showed that search for meaning mediates the effect of state boredom on nostalgic memory content, whereas Study 5 demonstrated that search for meaning mediates the effect of dispositional boredom on dispositional nostalgia. Finally, Study 6 examined the meaning reestablishment potential of nostalgia during boredom: Nostalgia mediates the effect of boredom on sense of meaningfulness and presence of meaning in one's life. Nostalgia counteracts the meaninglessness that individuals experience when they are bored.

  6. Concept Mapping Using Cmap Tools to Enhance Meaningful Learning

    Science.gov (United States)

    Cañas, Alberto J.; Novak, Joseph D.

    Concept maps are graphical tools that have been used in all facets of education and training for organizing and representing knowledge. When learners build concept maps, meaningful learning is facilitated. Computer-based concept mapping software such as CmapTools have further extended the use of concept mapping and greatly enhanced the potential of the tool, facilitating the implementation of a concept map-centered learning environment. In this chapter, we briefly present concept mapping and its theoretical foundation, and illustrate how it can lead to an improved learning environment when it is combined with CmapTools and the Internet. We present the nationwide “Proyecto Conéctate al Conocimiento” in Panama as an example of how concept mapping, together with technology, can be adopted by hundreds of schools as a means to enhance meaningful learning.

  7. Early- versus Late-Onset Dysthymia: A Meaningful Clinical Distinction?

    OpenAIRE

    Sansone, Randy A.; Sansone, Lori A.

    2009-01-01

    In the current Diagnostic and Statistical Manual of Mental Disorders, dysthymic disorder is categorized as either early-onset or late-onset, based upon the emergence of symptoms before or after the age of 21, respectively. Does this diagnostic distinction have any meaningful clinical implications? In this edition of The Interface, we present empirical studies that have, within a single study, compared individuals with early-versus late-onset dysthymia. In this review, we found that, compared ...

  8. Predictive value of EndTidalCO2, lung mechanics and other standard parameters for weaning neurological patients from mechanical ventilation

    Directory of Open Access Journals (Sweden)

    Hala A. Mohammad

    2016-01-01

    Conclusion: We concluded that measurements of RSBI, MIP (maximum inspiratory pressure, EndTidalCO2 and dynamic compliance were more accurate predictors of extubation failure in patients with neurological insults than other standard weaning parameters.

  9. Inventory parameters

    CERN Document Server

    Sharma, Sanjay

    2017-01-01

    This book provides a detailed overview of various parameters/factors involved in inventory analysis. It especially focuses on the assessment and modeling of basic inventory parameters, namely demand, procurement cost, cycle time, ordering cost, inventory carrying cost, inventory stock, stock out level, and stock out cost. In the context of economic lot size, it provides equations related to the optimum values. It also discusses why the optimum lot size and optimum total relevant cost are considered to be key decision variables, and uses numerous examples to explain each of these inventory parameters separately. Lastly, it provides detailed information on parameter estimation for different sectors/products. Written in a simple and lucid style, it offers a valuable resource for a broad readership, especially Master of Business Administration (MBA) students.

  10. Default values

    International Nuclear Information System (INIS)

    1987-08-01

    In making calculations for the purposes of radiation protection, numerical values for parameters used in the calculations are selected. In some cases, data directly applicable to the set of conditions for which the calculations are to be made are unavailable. Therefore, the selection of the values for these parameters may be based on more general data available from the literature or other sources. These values may be referred to as 'default values', that is, values used in default of those based on directly applicable data. The following policy will be applied by Atomic Energy Control Board (AECB) staff in reviewing the radiation protection aspects of submissions associated with licensing, in participating with other organizations in the development of codes and standards, and in any other work which relies to some extent on using default values

  11. Effect of Spindle Parameters of Woodworking Band Saw on the AE Value of Crack Band Saw Blade in Compound Material Processing (1)

    Science.gov (United States)

    Gao, Jin-gui; Jiang, Zhao-fang; Luo, Lai-peng

    2017-04-01

    Taking the MJ3210A motion band saw as the research object, the AE value of the band saw blade vibration was obtained by analyzing the VIBSYS vibration signal acquisition and analysis software system in Beijing, and the change of the AE value of the band saw and the crack was found out. The experimental results show that in the MJ3210A sports car sawing machine, the band saw blade with width of 130 mm is used, and the AE value of the cracked band saw blade is well in the high band saw blade AE value. Under the best working condition of the band saw, the band saw blade AE If the value exceeds 104.7 dB (A) above, it means that the band saw blade has at least one crack length greater than 1.38 mm for the crack defect and the need to replace the band saw blade in time. Different species with saw blade of the AE value is different, white pine wood minimum, the largest oak wood; according to a variety of wood processing AE instrument value to determine the band saw blade crack to the situation; so as to fully rational use of band saw blade, The failure and the degree of development to find a new method.

  12. Significance of normalized residual activity value (Nora) - the new parameter of isotopic renography - for the diagnosis of patients with obstructive uropathy

    International Nuclear Information System (INIS)

    Juszczyk-Gontaszewska, M.; Gontaszewski, W.; Rogowski, F.

    2005-01-01

    The aim of this research was to establish NORA values typical of patients with compensated and uncompensated obstructive uropathy. 147 results of renoscintigraphies carried out after the application of Tc-99m DTPA with furosemide diuretic test were analyzed. The patients were divided into three groups: the group with compensated obstructive uropathy, the group with uncompensated obstructive uropathy, and the controlled group. NORA-1 and NORA-2 values were calculated in each patient, for each kidney separately. It was established that the mean NORA-1 values in the three groups (the controlled group, the compensated uropathy group, and the uncompensated uropathy group) were significantly different, thus enabling differentiation between them. Based on the examination described above, the following conclusions wee drawn: 1. NORA is an effective differentiation index for compensated and uncompensated uropathy. 2. NORA values should be routinely calculated in every case of isotopic diuretic renography. (author)

  13. Towards happiness: Experiences of work-role fit, meaningfulness and work engagement of industrial/organisational psychologists in South Africa

    Directory of Open Access Journals (Sweden)

    Llewellyn E. van Zyl

    2010-10-01

    Research purpose: The aim of this study was to determine how I/O psychologists experience the meaning of their work and to investigate the relationships between their experiences of work-role fit, meaning of work, psychological meaningfulness and work engagement, utilising the happiness framework proposed by Seligman (2002. Motivation for the study: I/O psychologists spend more than 88% of their working day with people, and they are primary role models for happiness in the workplace. Information about their work engagement and experiences of meaning is therefore needed. Research design, approach and method: A survey design was used. A convenience sample (n = 106 was taken of I/O psychologists in South Africa. A biographical questionnaire, the Work-Role Fit Scale, the Work-Life Questionnaire, the Psychological Meaningfulness Scale, the Work Engagement Scale and a survey measuring the actual and desired time spent on six broad categories of work were administered. Main findings: Work-role fit predicted psychological meaningfulness and work engagement. The calling orientation to work predicted both psychological meaningfulness and work engagement. Work-role fit mediated the relationship between the meaning of work and psychological meaningfulness. Work-role fit partially mediated the relationship between a calling orientation to work and work engagement. Practical implications: A calling orientation to work should be fostered in I/O psychologists because it contributes to experiences of work-role fit, psychological meaningfulness and work engagement. Contribution/value-add: The results of this study contribute to scientific knowledge about work-role fit, engagement and meaning as components of happiness of I/O psychologists.

  14. Association between clinically meaningful behavior problems and overweight in children.

    Science.gov (United States)

    Lumeng, Julie C; Gannon, Kate; Cabral, Howard J; Frank, Deborah A; Zuckerman, Barry

    2003-11-01

    To determine whether there is a relationship between clinically meaningful behavior problems and concurrent and future overweight in 8- to 11-year-old children. 1998 National Longitudinal Survey of Youth interview data for 8- to 11-year-old children and their mothers were analyzed. A Behavior Problems Index score >90th percentile was considered clinically meaningful. Child overweight was defined as a body mass index (BMI) >or=95th percentile for age and sex. Multiple logistic regression was used to control for potential confounders (selected a priori): child's sex, race, use of behavior-modifying medication, history of academic retention, and hours of television per day; maternal obesity, smoking status, marital status, education, and depressive symptoms; family poverty status; and Home Observation for Measurement of the Environment-Short Form (HOME-SF) cognitive stimulation score. In an attempt to elucidate temporal sequence, a second analysis was conducted with a subsample of normal-weight children who became overweight between 1996 and 1998 while controlling for BMI z score in 1996. The sample included 755 mother-child pairs. Of the potential confounding variables, race, maternal obesity, academic grade retention, maternal education, poverty status, and HOME-SF cognitive stimulation score acted as joint confounders, altering the relationship between behavior problems and overweight in the multiple logistic regression model. With these covariates in the final model, behavior problems were independently associated with concurrent child overweight (adjusted odds ratio: 2.95; 95% confidence interval: 1.34-6.49). The relationship was strengthened in the subsample of previously normal-weight children, with race, maternal obesity, HOME-SF cognitive stimulation score, and 1996 BMI z score acting as confounders (adjusted odds ratio: 5.23; 95% confidence interval: 1.37-19.9). Clinically meaningful behavior problems in 8- to 11-year-old children were independently

  15. Measuring meaningful learning in the undergraduate chemistry laboratory

    Science.gov (United States)

    Galloway, Kelli R.

    The undergraduate chemistry laboratory has been an essential component in chemistry education for over a century. The literature includes reports on investigations of singular aspects laboratory learning and attempts to measure the efficacy of reformed laboratory curriculum as well as faculty goals for laboratory learning which found common goals among instructors for students to learn laboratory skills, techniques, experimental design, and to develop critical thinking skills. These findings are important for improving teaching and learning in the undergraduate chemistry laboratory, but research is needed to connect the faculty goals to student perceptions. This study was designed to explore students' ideas about learning in the undergraduate chemistry laboratory. Novak's Theory of Meaningful Learning was used as a guide for the data collection and analysis choices for this research. Novak's theory states that in order for meaningful learning to occur the cognitive, affective, and psychomotor domains must be integrated. The psychomotor domain is inherent in the chemistry laboratory, but the extent to which the cognitive and affective domains are integrated is unknown. For meaningful learning to occur in the laboratory, students must actively integrate both the cognitive domain and the affective domains into the "doing" of their laboratory work. The Meaningful Learning in the Laboratory Instrument (MLLI) was designed to measure students' cognitive and affective expectations and experiences within the context of conducting experiments in the undergraduate chemistry laboratory. Evidence for the validity and reliability of the data generated by the MLLI were collected from multiple quantitative studies: a one semester study at one university, a one semester study at 15 colleges and universities across the United States, and a longitudinal study where the MLLI was administered 6 times during two years of general and organic chemistry laboratory courses. Results from

  16. Asymptotics of the Eigenvalues of a Self-Adjoint Fourth Order Boundary Value Problem with Four Eigenvalue Parameter Dependent Boundary Conditions

    Directory of Open Access Journals (Sweden)

    Manfred Möller

    2013-01-01

    Full Text Available Considered is a regular fourth order ordinary differential equation which depends quadratically on the eigenvalue parameter λ and which has separable boundary conditions depending linearly on λ. It is shown that the eigenvalues lie in the closed upper half plane or on the imaginary axis and are symmetric with respect to the imaginary axis. The first four terms in the asymptotic expansion of the eigenvalues are provided.

  17. The added value of quantitative analysis of on-therapy impedance-pH parameters in distinguishing refractory non-erosive reflux disease from functional heartburn.

    Science.gov (United States)

    Frazzoni, M; Conigliaro, R; Mirante, V G; Melotti, G

    2012-02-01

    By analysis of symptom-reflux association, endoscopy-negative refractory heartburn can be related to acid/non-acid refluxes with impedance-pH monitoring. Unfortunately, patients frequently do not report symptoms during the test. We aimed to assess the contribution of quantitative analysis of impedance-pH parameters added to symptom-reflux association in evaluating patients with endoscopy-negative heartburn refractory to high-dose proton pump inhibitor therapy. The symptom association probability (SAP), the symptom index (SI), the esophageal acid exposure time and the number of distal and proximal refluxes were assessed at on-therapy impedance-pH monitoring. Relationships with hiatal hernia and manometric findings were also evaluated. Eighty patients were prospectively studied. Refractory heartburn was more frequently related to reflux by a positive SAP/SI and/or abnormal impedance-pH parameters (52/80 cases) (65%) than by a positive SAP/SI only (38/80 cases) (47%) (P = 0.038). In patients with refractory non-erosive reflux disease (NERD) defined by a positive SAP/SI and/or abnormal impedance-pH parameters, the prevalence of hiatal hernia was significantly higher (56%vs 21%, P = 0.007) and the mean lower esophageal sphincter tone was significantly lower (18.7 vs 25.8 mmHg, P = 0.005) than in those (35%) with reflux-unrelated, i.e., functional heartburn (FH). On the contrary, no significant difference was observed subdividing patients according to a positive SAP/SI only. Quantitative analysis of impedance-pH parameters added to symptom-reflux association allows a subdivision of refractory-heartburn patients into refractory NERD and FH which is substantiated by pathophysiological findings and which restricts the diagnosis of FH to one third of cases. © 2011 Blackwell Publishing Ltd.

  18. The rSPA Processes of River Water-quality Analysis System for Critical Contaminate Detection, Classification Multiple-water-quality-parameter Values and Real-time Notification

    OpenAIRE

    Chalisa VEESOMMAI; Yasushi KIYOKI

    2016-01-01

    The water quality analysis is one of the most important aspects of designing environmental systems. It is necessary to realize detection and classification processes and systems for water quality analysis. The important direction is to lead to uncomplicated understanding for public utilization. This paper presents the river Sensing Processing Actuation processes (rSPA) for determination and classification of multiple-water- parameters in Chaophraya river. According to rSPA processes of multip...

  19. CT-angiography-based evaluation of the aortic annulus for prosthesis sizing in transcatheter aortic valve implantation (TAVI-predictive value and optimal thresholds for major anatomic parameters.

    Directory of Open Access Journals (Sweden)

    Florian Schwarz

    Full Text Available BACKGROUND/OBJECTIVES: To evaluate the predictive value of CT-derived measurements of the aortic annulus for prosthesis sizing in transcatheter aortic valve implantation (TAVI and to calculate optimal cutoff values for the selection of various prosthesis sizes. METHODS: The local IRB waived approval for this single-center retrospective analysis. Of 441 consecutive TAVI-patients, 90 were excluded (death within 30 days: 13; more than mild aortic regurgitation: 10; other reasons: 67. In the remaining 351 patients, the CoreValve (Medtronic and the Edwards Sapien XT valve (Edwards Lifesciences were implanted in 235 and 116 patients. Optimal prosthesis size was determined during TAVI by inflation of a balloon catheter at the aortic annulus. All patients had undergone CT-angiography of the heart or body trunk prior to TAVI. Using these datasets, the diameter of the long and short axis as well as the circumference and the area of the aortic annulus were measured. Multi-Class Receiver-Operator-Curve analyses were used to determine the predictive value of all variables and to define optimal cutoff-values. RESULTS: Differences between patients who underwent implantation of the small, medium or large prosthesis were significant for all except the large vs. medium CoreValve (all p's<0.05. Furthermore, mean diameter, annulus area and circumference had equally high predictive value for prosthesis size for both manufacturers (multi-class AUC's: 0.80, 0.88, 0.91, 0.88, 0.88, 0.89. Using the calculated optimal cutoff-values, prosthesis size is predicted correctly in 85% of cases. CONCLUSION: CT-based aortic root measurements permit excellent prediction of the prosthesis size considered optimal during TAVI.

  20. Meaningful interpretation of subdiffusive measurements in living cells (crowded environment) by fluorescence fluctuation microscopy.

    Science.gov (United States)

    Baumann, Gerd; Place, Robert F; Földes-Papp, Zeno

    2010-08-01

    In living cell or its nucleus, the motions of molecules are complicated due to the large crowding and expected heterogeneity of the intracellular environment. Randomness in cellular systems can be either spatial (anomalous) or temporal (heterogeneous). In order to separate both processes, we introduce anomalous random walks on fractals that represented crowded environments. We report the use of numerical simulation and experimental data of single-molecule detection by fluorescence fluctuation microscopy for detecting resolution limits of different mobile fractions in crowded environment of living cells. We simulate the time scale behavior of diffusion times tau(D)(tau) for one component, e.g. the fast mobile fraction, and a second component, e.g. the slow mobile fraction. The less the anomalous exponent alpha the higher the geometric crowding of the underlying structure of motion that is quantified by the ratio of the Hausdorff dimension and the walk exponent d(f)/d(w) and specific for the type of crowding generator used. The simulated diffusion time decreases for smaller values of alpha # 1 but increases for a larger time scale tau at a given value of alpha # 1. The effect of translational anomalous motion is substantially greater if alpha differs much from 1. An alpha value close to 1 contributes little to the time dependence of subdiffusive motions. Thus, quantitative determination of molecular weights from measured diffusion times and apparent diffusion coefficients, respectively, in temporal auto- and crosscorrelation analyses and from time-dependent fluorescence imaging data are difficult to interpret and biased in crowded environments of living cells and their cellular compartments; anomalous dynamics on different time scales tau must be coupled with the quantitative analysis of how experimental parameters change with predictions from simulated subdiffusive dynamics of molecular motions and mechanistic models. We first demonstrate that the crowding exponent

  1. Radionuclide Data Centre. Tasks and problems of obtaining the most reliable values of the nuclear physics characteristics of radionuclides and radiation physics parameters of radionuclide sources

    International Nuclear Information System (INIS)

    Chechev, V.P.

    1994-01-01

    Information is provided on the establishment of the Radionuclide Data Centre under the V.G. Khlopin Radium Institute. Its functions and areas of activity are discussed. The paper focuses on the procedure of obtaining the evaluated values of the decay and radiative characteristics of the widely used radionuclides. (author)

  2. The effect of gamma irradiation on the degree of ripening of mango by comparing the parameter of colour index, texture firmness and pH value

    International Nuclear Information System (INIS)

    Muhammad Hafiz Hanafi

    2012-01-01

    This study was carried out to determine the effect of low dose gamma irradiation on the ripening degree of cv Chokanan mangoes through the comparison of colour index changes, texture firmness and pH value. Harvested mature mango was studied through the storage period for 14 days. Dose level used were 0.00 kGy (control), 0.25 kGy, 0.50 kGy, 0.75 kGy and 1.00 kGy of gamma cell 220. All fruits were wrapped using plastic after irradiated. There was no change in 0 day. However, there are changes in colour index, firmness and pH value of fruits in after 3 days. Dose of 0.75 kGy and 1.00 kGy gave positive effect to storage extension period and rate deceleration compared to 0.00 kGy (control), 0.25 kGy and 0.50 kGy. After 10 days storage, 0.00, 0.25 and 0.50 kGy of fruits became rot which affects quality of organoleptic. Whereas 0.75 and 1.00 kGy still retained organoleptic quality . When the ripening rate of fruit was fast, this would lead to faster of the colour change. The firmness value of fruit became decrease and the value of pH was increase. (author)

  3. CT-angiography-based evaluation of the aortic annulus for prosthesis sizing in transcatheter aortic valve implantation (TAVI)-predictive value and optimal thresholds for major anatomic parameters.

    Science.gov (United States)

    Schwarz, Florian; Lange, Philipp; Zinsser, Dominik; Greif, Martin; Boekstegers, Peter; Schmitz, Christoph; Reiser, Maximilian F; Kupatt, Christian; Becker, Hans C

    2014-01-01

    To evaluate the predictive value of CT-derived measurements of the aortic annulus for prosthesis sizing in transcatheter aortic valve implantation (TAVI) and to calculate optimal cutoff values for the selection of various prosthesis sizes. The local IRB waived approval for this single-center retrospective analysis. Of 441 consecutive TAVI-patients, 90 were excluded (death within 30 days: 13; more than mild aortic regurgitation: 10; other reasons: 67). In the remaining 351 patients, the CoreValve (Medtronic) and the Edwards Sapien XT valve (Edwards Lifesciences) were implanted in 235 and 116 patients. Optimal prosthesis size was determined during TAVI by inflation of a balloon catheter at the aortic annulus. All patients had undergone CT-angiography of the heart or body trunk prior to TAVI. Using these datasets, the diameter of the long and short axis as well as the circumference and the area of the aortic annulus were measured. Multi-Class Receiver-Operator-Curve analyses were used to determine the predictive value of all variables and to define optimal cutoff-values. Differences between patients who underwent implantation of the small, medium or large prosthesis were significant for all except the large vs. medium CoreValve (all p'sprosthesis size for both manufacturers (multi-class AUC's: 0.80, 0.88, 0.91, 0.88, 0.88, 0.89). Using the calculated optimal cutoff-values, prosthesis size is predicted correctly in 85% of cases. CT-based aortic root measurements permit excellent prediction of the prosthesis size considered optimal during TAVI.

  4. Myasthenia Gravis Impairment Index: Responsiveness, meaningful change, and relative efficiency.

    Science.gov (United States)

    Barnett, Carolina; Bril, Vera; Kapral, Moira; Kulkarni, Abhaya V; Davis, Aileen M

    2017-12-05

    To study responsiveness and meaningful change of the Myasthenia Gravis Impairment Index (MGII) and its relative efficiency compared to other measures. We enrolled 95 patients receiving prednisone, IV immunoglobulin (IVIg), or plasma exchange (PLEX) and 54 controls. Patients were assessed with the MGII and other measures-including the Quantitative Myasthenia Gravis Score, Myasthenia Gravis Composite, and Myasthenia Gravis Activities of Daily Living-at baseline and 3-4 weeks after treatment. Statistical markers of responsiveness included between-groups and within-group differences, and we estimated the relative efficiency of the MGII compared to other measures. Patient-meaningful change was assessed with an anchor-based method, using the patient's impression of change. We determined the minimal detectable change (MDC) and the minimal important difference (MID) at the group and individual level. Treated patients had a higher change in MGII scores than controls (analysis of covariance p 1 favoring the MGII. The MGII demonstrated responsiveness to prednisone, IVIg, and PLEX in patients with myasthenia. There is a differential response in ocular and generalized symptoms to type of therapy. The MGII has higher relative efficiency than comparison measures and is viable for use in clinical trials. Copyright © 2017 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the American Academy of Neurology.

  5. Learning about physical parameters: the importance of model discrepancy

    International Nuclear Information System (INIS)

    Brynjarsdóttir, Jenný; O'Hagan, Anthony

    2014-01-01

    Science-based simulation models are widely used to predict the behavior of complex physical systems. It is also common to use observations of the physical system to solve the inverse problem, that is, to learn about the values of parameters within the model, a process which is often called calibration. The main goal of calibration is usually to improve the predictive performance of the simulator but the values of the parameters in the model may also be of intrinsic scientific interest in their own right. In order to make appropriate use of observations of the physical system it is important to recognize model discrepancy, the difference between reality and the simulator output. We illustrate through a simple example that an analysis that does not account for model discrepancy may lead to biased and over-confident parameter estimates and predictions. The challenge with incorporating model discrepancy in statistical inverse problems is being confounded with calibration parameters, which will only be resolved with meaningful priors. For our simple example, we model the model-discrepancy via a Gaussian process and demonstrate that through accounting for model discrepancy our prediction within the range of data is correct. However, only with realistic priors on the model discrepancy do we uncover the true parameter values. Through theoretical arguments we show that these findings are typical of the general problem of learning about physical parameters and the underlying physical system using science-based mechanistic models. (paper)

  6. Constructing an allocation factor based on product and process related parameters to assess environmental burdens of producing value-added sludge-based products

    OpenAIRE

    Pradel, M.; Aissani, L.; Canler, J.C.; Roux, J.C.; Villot, J.; Baudez, J.C.; Laforest, V.

    2018-01-01

    Sludge is slowly moving away from providing basic by-products and towards providing value-added products (e.g. fertilisers); therefore, it is no longer perceived as waste but as a product. Consequently, wastewater treatment plants become multifunctional systems that produce two coproducts that are given a second life: sludge and "clean" water. An allocation factor in Life Cycle Assessment can partition environmental burdens of wastewater treatment between these two products, but doing so rema...

  7. Predictive impact on medium-term mortality of hematological parameters in Acute Coronary Syndromes: added value on top of GRACE risk score.

    Science.gov (United States)

    Timóteo, Ana T; Papoila, Ana L; Lousinha, Ana; Alves, Marta; Miranda, Fernando; Ferreira, Maria L; Ferreira, Rui C

    2015-04-01

    Red Cell Distribution Width (RDW) prognostic value in patients with Acute Coronary Syndrome (ACS) has been well validated whereas that of Platelet Distribution Width (PDW) is less well known. Investigate the incremental prognostic value, on top of GRACE risk score, of a new variable resulting from the combination of RDW and PDW. Consecutive patients with ACS. Complete blood count, with RDW and PDW, was obtained. Primary endpoint was one-year all-cause mortality and Cox regression models were used to measure the influence of RDW and PDW on patients' survival time. A new combination categorical variable (RDW/PDW) was created with both discretized RDW and PDW and logistic regression models were used. Predictive value and discriminative ability of the model with GRACE risk score alone and of the model with inclusion of RDW/PDW was assessed. We included 787 patients. Hospital and one-year mortality rates were 5.1% and 7.8%, respectively. Both continuous RDW and PDW were independent predictors of death. The best cut-off for RDW was 13.9%, and 14.5% for PDW. Inclusion of RDW/PDW in a model with GRACE risk score improved the AUC from 0.81 (95% CI 0.75-0.86) to 0.84 (95% CI 0.79-0.90) (p=0.024) with an improvement in total NRI (56%) and IDI (0.048). Simple markers such as RDW and PDW can be useful in risk stratification of death after ACS. Combining both markers with GRACE risk score improved the predictive value for all-cause mortality and reduced the estimated risk of those who did not die. © The European Society of Cardiology 2014.

  8. The Value of Quality Improvement Process in the Detection and Correction of Common Errors in Echocardiographic Hemodynamic Parameters in a Busy Echocardiography Laboratory.

    Science.gov (United States)

    Fanari, Zaher; Choudhry, Usman I; Reddy, Vivek K; Eze-Nliam, Chete; Hammami, Sumaya; Kolm, Paul; Weintraub, William S; Marshall, Erik S

    2015-12-01

    Accurate assessment of cardiac structures, ventricular function, and hemodynamics is essential for any echocardiographic laboratory. Quality improvement (QI) processes described by the American Society of Echocardiography (ASE) and the Intersocietal Commission (IAC) should be instrumental in reaching this goal. All patients undergoing transthoracic echocardiogram (TTE) followed by cardiac catheterization within 24 hours at Christiana Care Health System in 2011 and 2012 were identified, with 126 and 133 cases, respectively. Hemodynamic parameters of diastolic function and pulmonary artery systolic pressure (PASP) on TTE correlated poorly with catheterization in 2011. An educational process was developed and implemented at quarterly QI meetings based on ASE and IAC recommendations to target frequently encountered errors and provide methods for improved performance. The hemodynamic parameters were then reexamined in 2012 postintervention. Following the QI process, there was significant improvement in the correlation between invasive and echocardiographic hemodynamic measurements in both systolic and diastolic function, and PASP. This reflected in significant better correlations between echo and cath LVEF [R = 0.88, ICC = 0.87 vs. R = 0.85, ICC = 0.85; P process, as recommended by ASE and IAC, can allow for identification as well as rectification of quality issues in a large regional academic medical center hospital. © 2015, Wiley Periodicals, Inc.

  9. Displacement cascades and defect annealing in tungsten, Part III: The sensitivity of cascade annealing in tungsten to the values of kinetic parameters

    Energy Technology Data Exchange (ETDEWEB)

    Nandipati, Giridhar, E-mail: giridhar.nandipati@pnnl.gov [Pacific Northwest National Laboratory, Richland, WA (United States); Setyawan, Wahyu; Heinisch, Howard L. [Pacific Northwest National Laboratory, Richland, WA (United States); Roche, Kenneth J. [Pacific Northwest National Laboratory, Richland, WA (United States); Department of Physics, University of Washington, Seattle, WA 98195 (United States); Kurtz, Richard J. [Pacific Northwest National Laboratory, Richland, WA (United States); Wirth, Brian D. [University of Tennessee, Knoxville, TN (United States)

    2015-07-15

    A study has been performed using object kinetic Monte Carlo (OKMC) simulations to investigate various aspects of cascade aging in bulk tungsten (W) and to determine its sensitivity to the kinetic parameters. The primary focus is on how the kinetic parameters affect the intracascade recombination of defects. Results indicate that, due to the disparate mobilities of SIA and vacancy clusters, annealing is dominated by SIA migration even at 2050 K. It was found that for 100 keV cascades initiated at 300 K, recombination is dominated by the annihilation of large defect clusters, while for all the other primary knock-on atom (PKA) energies and temperatures, recombination is primarily due to the migration and rotation of small SIA clusters, while the large SIA clusters escape the simulation cell. The annealing efficiency exhibits an inverse U-shaped curve behavior with increasing temperature, especially at large PKA energies, caused by the asymmetry in SIA and vacancy clustering assisted by the large differences in their mobilities. This behavior is unaffected by the dimensionality of SIA migration, and it persists over a broad range of relative mobilities of SIAs and vacancies.

  10. Predictive value of PSA velocity over early clinical and pathological parameters in patients with localized prostate cancer who undergo radical retropubic prostatectomy

    Directory of Open Access Journals (Sweden)

    Martinez Carlos A.L.

    2004-01-01

    Full Text Available OBJECTIVES: To analyze the behavior of the prostate specific antigen velocity (PSAV in localized prostate adenocarcinoma. MATERIALS AND METHODS: We conducted a retrospective study of 500 men who had localized prostate adenocarcinoma, who underwent radical retropubic prostatectomy between January 1986 and December 1999. The PSAV was calculated for each patient and subsequently, the values were correlated with 5 groups: age, initial PSA value, clinical stage, tumor volume and Gleason score. RESULTS: The behavior of PSAV presented statistic significance with an increment between 1.3 ng/mL and 9.6 ng/mL, ranging from 38.6% and 59.8% when compared with the initial PSA value (p < 0.0001, clinical stage (p = 0.0002, tumor volume (p < 0.0001 and Gleason score (p = 0.0009. CONCLUSION: PSAV up to 2.5 ng/mL/year is associated with factors of good prognosis, such as initial PSA below 10 mg/mL, clinical stage T1, tumor volume below 20% and Gleason score lower than 7.

  11. Displacement cascades and defect annealing in tungsten, Part III: The sensitivity of cascade annealing in tungsten to the values of kinetic parameters

    Energy Technology Data Exchange (ETDEWEB)

    Nandipati, Giridhar; Setyawan, Wahyu; Heinisch, Howard L.; Roche, Kenneth J.; Kurtz, Richard J.; Wirth, Brian D.

    2015-07-01

    Object kinetic Monte Carlo (OKMC) simulations have been performed to investigate various aspects of cascade aging in bulk tungsten and to determine the sensitivity of the results to the kinetic parameters. The primary focus is on how the kinetic parameters affect the initial recombination of defects in the first few ns of a simulation. The simulations were carried out using the object kinetic Monte Carlo (OKMC) code KSOME (kinetic simulations of microstructure evolution), using a database of cascades obtained from results of molecular dynamics (MD) simulations at various primary knock-on atom (PKA) energies and directions at temperatures of 300, 1025 and 2050 K. The OKMC model was parameterized using defect migration barriers and binding energies from ab initio calculations. Results indicate that, due to the disparate mobilities of SIA and vacancy clusters in tungsten, annealing is dominated by SIA migration even at temperatures as high as 2050 K. For 100 keV cascades initiated at 300 K recombination is dominated by annihilation of large defect clusters. But for all other PKA energies and temperatures most of the recombination is due to the migration and rotation of small SIA clusters, while all the large SIA clusters escape the cubic simulation cell. The inverse U-shape behavior exhibited by the annealing efficiency as a function of temperature curve, especially for cascades of large PKA energies, is due to asymmetry in SIA and vacancy clustering assisted by the large difference in mobilities of SIAs and vacancies. This annealing behavior is unaffected by the dimensionality of SIA migration persists over a broad range of relative mobilities of SIAs and vacancies.

  12. Asymptotic value of screening parameter as determined from the one-electron fragment of the kinetic energy or electrostatic potential at the nucleus

    International Nuclear Information System (INIS)

    Teruya, Hirohide; Anno, Tosinobu

    1985-01-01

    Numerical value of lim sub(Z → infinity) delta(i, j)/delta Zsub(i), where (i, j) stands for average interaction energy of a pair of electrons embedded in hydrogenic orbitals (HAO's) is presented for a wide range of HAO's. Data to be presented should be useful to calculate the asymptotic limit of screening effect seen by an electron embedded in a given kind of orbital for an isoelectronic series of atoms as determined from the ''one-electron component'' of the total kinetic energy of or of the electrostatic potential at the nucleus within an atom. (author)

  13. Asymptotic value of screening parameter as determined from the one-electron fragment of the kinetic energy or electrostatic potential at the nucleus

    Energy Technology Data Exchange (ETDEWEB)

    Teruya, Hirohide; Anno, Tosinobu

    1985-09-01

    Numerical value of lim sub(Z ..-->.. infinity) delta(i, j)/delta Zsub(i), where (i, j) stands for average interaction energy of a pair of electrons embedded in hydrogenic orbitals (HAO's) is presented for a wide range of HAO's. Data to be presented should be useful to calculate the asymptotic limit of screening effect seen by an electron embedded in a given kind of orbital for an isoelectronic series of atoms as determined from the ''one-electron component'' of the total kinetic energy of or of the electrostatic potential at the nucleus within an atom.

  14. Kinematic analysis of the gait of adult sheep during treadmill locomotion: Parameter values, allowable total error, and potential for use in evaluating spinal cord injury.

    Science.gov (United States)

    Safayi, Sina; Jeffery, Nick D; Shivapour, Sara K; Zamanighomi, Mahdi; Zylstra, Tyler J; Bratsch-Prince, Joshua; Wilson, Saul; Reddy, Chandan G; Fredericks, Douglas C; Gillies, George T; Howard, Matthew A

    2015-11-15

    We are developing a novel intradural spinal cord (SC) stimulator designed to improve the treatment of intractable pain and the sequelae of SC injury. In-vivo ovine models of neuropathic pain and moderate SC injury are being implemented for pre-clinical evaluations of this device, to be carried out via gait analysis before and after induction of the relevant condition. We extend previous studies on other quadrupeds to extract the three-dimensional kinematics of the limbs over the gait cycle of sheep walking on a treadmill. Quantitative measures of thoracic and pelvic limb movements were obtained from 17 animals. We calculated the total-error values to define the analytical performance of our motion capture system for these kinematic variables. The post- vs. pre-injury time delay between contralateral thoracic and pelvic-limb steps for normal and SC-injured sheep increased by ~24s over 100 steps. The pelvic limb hoof velocity during swing phase decreased, while range of pelvic hoof elevation and distance between lateral pelvic hoof placements increased after SC injury. The kinematics measures in a single SC-injured sheep can be objectively defined as changed from the corresponding pre-injury values, implying utility of this method to assess new neuromodulation strategies for specific deficits exhibited by an individual. Copyright © 2015 Elsevier B.V. All rights reserved.

  15. Pyrolysis of Lantana camara and Mimosa pigra: Influences of temperature, other process parameters and incondensable gas evolution on char yield and higher heating value.

    Science.gov (United States)

    Mundike, Jhonnah; Collard, François-Xavier; Görgens, Johann F

    2017-11-01

    Pyrolysis of invasive non-indigenous plants, Lantana camara (LC) and Mimosa pigra (MP) was conducted at milligram-scale for optimisation of temperature, heating rate and hold time on char yield and higher heating value (HHV). The impact of scaling-up to gram-scale was also studied, with chromatography used to correlate gas composition with HHV evolution. Statistically significant effects of temperature on char yield and HHV were obtained, while heating rate and hold time effects were insignificant. Milligram-scale maximised HHVs were 30.03MJkg -1 (525°C) and 31.01MJkg -1 (580°C) for LC and MP, respectively. Higher char yields and HHVs for MP were attributed to increased lignin content. Scaling-up promoted secondary char formation thereby increasing HHVs, 30.82MJkg -1 for LC and 31.61MJkg -1 for MP. Incondensable gas analysis showed that temperature increase beyond preferred values caused dehydrogenation that decreased HHV. Similarly, CO evolution profile explained differences in optimal HHV temperatures. Copyright © 2017 Elsevier Ltd. All rights reserved.

  16. The measurement of water scarcity: Defining a meaningful indicator.

    Science.gov (United States)

    Damkjaer, Simon; Taylor, Richard

    2017-09-01

    Metrics of water scarcity and stress have evolved over the last three decades from simple threshold indicators to holistic measures characterising human environments and freshwater sustainability. Metrics commonly estimate renewable freshwater resources using mean annual river runoff, which masks hydrological variability, and quantify subjectively socio-economic conditions characterising adaptive capacity. There is a marked absence of research evaluating whether these metrics of water scarcity are meaningful. We argue that measurement of water scarcity (1) be redefined physically in terms of the freshwater storage required to address imbalances in intra- and inter-annual fluxes of freshwater supply and demand; (2) abandons subjective quantifications of human environments and (3) be used to inform participatory decision-making processes that explore a wide range of options for addressing freshwater storage requirements beyond dams that include use of renewable groundwater, soil water and trading in virtual water. Further, we outline a conceptual framework redefining water scarcity in terms of freshwater storage.

  17. School nurse evaluations: making the process meaningful and motivational.

    Science.gov (United States)

    McDaniel, Kathryn H; Overman, Muriel; Guttu, Martha; Engelke, Martha Keehner

    2013-02-01

    The professional standards of school nursing practice provide a framework to help school nurses focus on their unique mission of promoting health and academic achievement for all students. Without the standards, the nurse's role can become task oriented and limited in scope. By using an evaluation tool that reflects the standards, nurses not only become aware and begin to understand the standards; they also become directly accountable for meeting them. In addition, developing an evaluation process based on the standards of school nurse practice increases the visibility of school nurses and helps school administrators understand the role of the school nurse. This article describes how one school district integrated the scope and standards of school nursing into the job description and performance evaluation of the nurse. The process which is used to complete the evaluation in a manner that is meaningful and motivational to the school nurse is described.

  18. Effect of different pH-values on process parameters in two-phase anaerobic digestion of high-solid substrates.

    Science.gov (United States)

    Lindner, Jonas; Zielonka, Simon; Oechsner, Hans; Lemmer, Andreas

    2015-01-01

    In many publications, primary fermentation is described as a limiting step in the anaerobic digestion of fibre-rich biomass [Eastman JA, Ferguson JF. Solubilization of particulacte carbon during the anaerobic digeston. J WPCF. 1981;53:352-366; Noike T, Endo G, Chang J, Yaguchi J, Matsumoto J. Characteristics of carbohydrate degradation and the rate-limiting step in anaerobic digestion. Biotechnol Bioeng. 1985;27:1482-1489; Arntz HJ, Stoppok E, Buchholz K. Anaerobic hydroysis of beet pulp-discontiniuous experiments. Biotechnol Lett. 1985;7:113-118]. The microorganisms of the primary fermentation process differ widely from the methanogenic microorganisms [Pohland FG, Ghosh S. Developments in anaerobic stabilization of organic wastes-the two-phase concept. Environ Lett. 1971;1:255-266]. To optimize the biogas process, a separation in two phases is suggested by many authors [Fox P, Pohland GK. Anaerobic treatment applications and fundamentals: substrate specificity during phase separation. Water Environ Res. 1994;66:716-724; Cohen A, Zoetemeyer RJ, van Deursen A, van Andel JG. Anaerobic digestion of glucose with separated acid production and methane formation. Water Res. 1979;13:571-580]. To carry out the examination, a two-phase laboratory-scale biogas plant was established, with a physical phase separation. In previous studies, the regulation of the pH-value during the acid formation was usually carried out by the addition of sodium hydroxide [Cohen A, Zoetemeyer RJ, van Deursen A, van Andel JG. Anaerobic digestion of glucose with separated acid production and methane formation. Water Res. 1979;13:571-580; Ueno Y, Tatara M, Fukui H, Makiuchi T, Goto M, Sode K. Production of hydrogen and methane from organic solid wastes by phase separation of anaerobic process. Bioresour Technol. 2007;98:1861-1865; Zoetemeyer RJ, van den Heuvel JC, Cohen A. pH influence on acidogenic dissimilation of glucose in an anaerobic digestor. Water Res. 1982;16:303-311]. A new technology

  19. Analysis of the value recommended by the NCRP 151 and its relationship with Brazilian parameters;Analise dos valores recomendados pelo NCRP 151 e sua relacao com parametros brasileiros

    Energy Technology Data Exchange (ETDEWEB)

    Groppo, Daniela P. [UNESP, Botucatu, SP (Brazil). Inst. de Biociencias; Martins, Homero L. [Hospital A.C. Camargo, Sao Paulo, SP (Brazil). Servico de Fisica Medica

    2009-07-01

    The methodology proposed by the National Council on Radiation Protection 151 (NCRP 151), relates technical information necessary to structural shielding design and evaluation for megavoltage X- and gamma- ray radiotherapy facilities. However, many parameters used to calculate the shield are based on estimates, and may not be adequate to the Brazilian reality. Thus, the central idea of this study is to obtain parameters and is to outline a profile closer to the treatments carried out in facilities in Brazil, through a data collection routine of the Department of Radiotherapy Service of the Real e Benemerita Associacao Portuguesa de Beneficencia, in particular the cobalt therapy Theratron 780 (Atomic Energy of Canada Ltd.) and the linear accelerator Varian Clinac 2100C for measurement of workload, use factor, number of patients, fields, dose and anatomic region treated. So, the work did not draw definite values of the parameters, but indicative values were obtained which showed the importance to carry out more detailed studies of the recommended values. (author)

  20. Wheel brake with mechatronic parameter value control - investigation of operating behaviour and driver integration problems, with particurticular regard to brake-by-wire systems; Radbremse mit mechatronischer Kennwertregelung - Untersuchung von Betriebsverhalten und Fahreranbindungsproblematik, hinsichtlich Brake-by-Wire-Systemen

    Energy Technology Data Exchange (ETDEWEB)

    Leber, M.

    1998-11-01

    The book presents a new brake system with mechatronically controlled self-energizing and with low energy demand. Potentials and limits of mechatronic parameter value control are pointed out with a view towards future brake-by-wire systems. Measurements on a parameter-controlled duplex drum brake provide information on the response to different disturbances. The possibility of influencing the driver by parameter-controlled wheel brakes were investigated in a novel experimental vehicle with freely programmable brake system parameters, and the main paramters of the driver/brake system interface were identified. The report ends with a few words on adaptive brake systems which can combine optimum driving efficiency with maximum comfort in all possible driving situations. (orig.) [Deutsch] Das vorliegende Buch stellt eine neuartige Fahrzeugbremse mit mechatronisch geregelter Selbstverstaerkung vor, die einen niedrigen Spannenergiebedarf aufweist. Im Hinblick auf zukuenftige Brake-by-Wire-Systeme werden Potentiale, aber auch Grenzen einer mechatronischen Kennwertregelung aufgezeigt. Messungen an einer kennwertgeregelten Duplex-Trommelbremse geben Aufschluss ueber das Betriebsverhalten unter Einfluss verschiedener Stoergroessen. Die Moeglichkeiten einer Fahrerbeeinflussung durch kennwertgeregelte Radbremsen werden mittels eines neuartigen Versuchsfahrzeugs mit frei programmierbaren Bremssystemparametern untersucht. Darueber hinaus wird die Schnittstelle Fahrer/Bremssystem hinsichtlich ihrer bestimmenden Parameter beschrieben. Den Schluss der Arbeit bildet ein Ausblick auf adaptive Bremssysteme mit dem Potential, optimale fahrdynamische Effizienz bei groesstmoeglichem Komfort situationsabhaengig darzustellen. (orig.)

  1. Influence of different organic fertilizers on quality parameters and the delta(15)N, delta(13)C, delta(2)H, delta(34)S, and delta(18)O values of orange fruit (Citrus sinensis L. Osbeck).

    Science.gov (United States)

    Rapisarda, Paolo; Camin, Federica; Fabroni, Simona; Perini, Matteo; Torrisi, Biagio; Intrigliolo, Francesco

    2010-03-24

    To investigate the influence of different types of fertilizers on quality parameters, N-containing compounds, and the delta(15)N, delta(13)C, delta(2)H, delta (34)S, and delta(18)O values of citrus fruit, a study was performed on the orange fruit cv. 'Valencia late' (Citrus sinensis L. Osbeck), which was harvested in four plots (three organic and one conventional) located on the same farm. The results demonstrated that different types of organic fertilizers containing the same amount of nitrogen did not effect important changes in orange fruit quality parameters. The levels of total N and N-containing compounds such as synephrine in fruit juice were not statistically different among the different treatments. The delta(15)N values of orange fruit grown under fertilizer derived from animal origin as well as from vegetable compost were statistically higher than those grown with mineral fertilizer. Therefore, delta(15)N values can be used as an indicator of citrus fertilization management (organic or conventional), because even when applied organic fertilizers are of different origins, the natural abundance of (15)N in organic citrus fruit remains higher than in conventional ones. These treatments also did not effect differences in the delta(13)C, delta(2)H, delta(34)S, and delta(18)O values of fruit.

  2. The dynamics of meaningful social interactions and the emergence of collective knowledge

    Science.gov (United States)

    Dankulov, Marija Mitrović; Melnik, Roderick; Tadić, Bosiljka

    2015-07-01

    Collective knowledge as a social value may arise in cooperation among actors whose individual expertise is limited. The process of knowledge creation requires meaningful, logically coordinated interactions, which represents a challenging problem to physics and social dynamics modeling. By combining two-scale dynamics model with empirical data analysis from a well-known Questions & Answers system Mathematics, we show that this process occurs as a collective phenomenon in an enlarged network (of actors and their artifacts) where the cognitive recognition interactions are properly encoded. The emergent behavior is quantified by the information divergence and innovation advancing of knowledge over time and the signatures of self-organization and knowledge sharing communities. These measures elucidate the impact of each cognitive element and the individual actor’s expertise in the collective dynamics. The results are relevant to stochastic processes involving smart components and to collaborative social endeavors, for instance, crowdsourcing scientific knowledge production with online games.

  3. Youth Perspectives on Meaningful Participation in Community Based Programs: A Qualitative Assessment

    Directory of Open Access Journals (Sweden)

    Sherer W. Royce

    2009-12-01

    Full Text Available Allowing the voiceless to have a voice is a tenet of empowerment. This paper highlights research that employed a participatory action research framework to gain a better understanding of young people’s perceptions about youth empowerment and acquire their perspective (voice about the meaningfulness of participation in out-of-school advocacy and volunteer program activities. Using Photovoice, the research provides a missing point of view in youth empowerment model development. Results indicate that the quality of a youth’s participation in a community-based program is determined by 1 youth expressing themselves without censorship, 2 occasions for youth to expand their social networks with youth and adults, and 3 adults observing and valuing youth contributions. These findings raise implications for community-based, youth empowerment programs including program philosophy, program procedures, youth empowerment content and activities, and adult leadership style. The findings may assist practitioners when designing youth empowering activities and researchers when operationalizing youth empowerment.

  4. Can business impact analysis play a meaningful role in planning a cost-saving programme?

    Science.gov (United States)

    Wright, Trevor

    2011-02-01

    Business continuity as it exists today would appear to have reached something of a plateau. Considering the history of the discipline, and how it has developed from 'simple' disaster recovery to its present position, it is clear that the trend has been to move from a reactive discipline to a proactive process. Following on from this broadly-accepted point, it is perhaps time to consider how the discipline may develop and what wider and deeper contribution the business continuity profession may make to add further value for our clients. In the present climate, it seems appropriate to consider how (and if) business continuity practice can make a meaningful contribution to a cost saving exercise. The public and private sectors are considered and the differences are compared.

  5. Sacrifice: an ethical dimension of caring that makes suffering meaningful.

    Science.gov (United States)

    Helin, Kaija; Lindström, Unni A

    2003-07-01

    This article is intended to raise the question of whether sacrifice can be regarded stituting a deep ethical structure in the relationship between patient and carer. The significance of sacrifice in a patient-carer relationship cannot, however, be fully understood from the standpoint of the consistently utilitarian ethic that characterizes today's ethical discourse. Deontological ethics, with its universal principles, also does not provide a suitable point of departure. Ethical recommendations and codices are important and serve as general sources of knowledge when making decisions, but they should be supplemented by an ethic that takes into consideration contextual and situational factors that make every encounter between patient and carer unique. Caring science research literature presents, on the whole, general agreement on the importance of responsibility and devotian with regard to sense of duty, warmth and genuine engagement in caring. That sacrifice may also constitute an important ethical element in the patient-carer relationship is, however, a contradictory and little considered theme. Caring literature that deals with sacrifice/self-sacrifice indicates contradictory import. It is nevertheless interesting to notice that both the negative and the positive aspects bring out importance of the concept for the professional character of caring. The tradition of ideas in medieval Christian mysticism with reference to Lévinas' ethic of responsibility offers a deeper perspective in which the meaningfulness of sacrifice in the caring relationship can be sought. The theme of sacrifice is not of interest merely as a carer's ethical outlook, but sacrifice can also be understood as a potential process of transformation health. The instinctive or conscious experience of sacrifice on the part of the individual patient can, on a symbolic level, be regarded as analogous to the cultic or religious sacrifice aiming at atonement. Sacrifice appears to the patient as an act of

  6. The examination of biophysical parameters of skin (transepidermal water loss, skin hydration and pH value) in different body regions of normal cats of both sexes.

    Science.gov (United States)

    Szczepanik, Marcin P; Wilkołek, Piotr M; Adamek, Lukasz R; Pomorski, Zbigniew J H

    2011-04-01

    The purpose of this study was to evaluate transepidermal water loss (TEWL), skin hydration and skin pH in normal cats. Twenty shorthaired European cats of both sexes were examined in the study. Measurements were taken from five different sites: the lumbar region, the axillary fossa, the inguinal region, the ventral abdominal region and the left thoracic region. In each of the regions, TEWL, skin hydration and skin pH were measured. The highest TEWL value was observed in the axillary fossa (18.22g/h/m(2)) and the lowest in the lumbar region (10.53g/h/m(2)). The highest skin hydration was found in the inguinal region (18.29CU) and the lowest in the lumbar region (4.62CU). The highest skin pH was observed in the inguinal region (6.64) and the lowest in the lumbar region (6.39). Statistically significant differences in TEWL were observed between the lumbar region and the left side of the thorax region (P=0.016), the axillary fossa (P=0.0004), the ventral region (P=0.005), and the inguinal region (P=0.009). There were significant differences in skin hydration between the lumbar region and the left thorax (P=0.000003), the axillary fossa (P=0.002), the ventral abdomen (P=0.03), and the inguinal region (P=0.0003) as well as between the thorax and the ventral abdomen (P=0.005). TEWL was higher in females (15g/h/m(2)) than in males (4.57g/h/m(2)). Skin hydration was higher in females (13.89CU) than in males (12.28CU). Significant differences were not found between males and females for TEWL and skin hydration. Skin pH was higher in males (6.94) than in females (6.54), which was significant (P=0.004). Crown Copyright © 2010. Published by Elsevier Ltd. All rights reserved.

  7. Sensitivity of Claims-Based Algorithms to Ascertain Smoking Status More Than Doubled with Meaningful Use.

    Science.gov (United States)

    Huo, Jinhai; Yang, Ming; Tina Shih, Ya-Chen

    2018-03-01

    The "meaningful use of certified electronic health record" policy requires eligible professionals to record smoking status for more than 50% of all individuals aged 13 years or older in 2011 to 2012. To explore whether the coding to document smoking behavior has increased over time and to assess the accuracy of smoking-related diagnosis and procedure codes in identifying previous and current smokers. We conducted an observational study with 5,423,880 enrollees from the year 2009 to 2014 in the Truven Health Analytics database. Temporal trends of smoking coding, sensitivity, specificity, positive predictive value, and negative predictive value were measured. The rate of coding of smoking behavior improved significantly by the end of the study period. The proportion of patients in the claims data recorded as current smokers increased 2.3-fold and the proportion of patients recorded as previous smokers increased 4-fold during the 6-year period. The sensitivity of each International Classification of Diseases, Ninth Revision, Clinical Modification code was generally less than 10%. The diagnosis code of tobacco use disorder (305.1X) was the most sensitive code (9.3%) for identifying smokers. The specificities of these codes and the Current Procedural Terminology codes were all more than 98%. A large improvement in the coding of current and previous smoking behavior has occurred since the inception of the meaningful use policy. Nevertheless, the use of diagnosis and procedure codes to identify smoking behavior in administrative data is still unreliable. This suggests that quality improvements toward medical coding on smoking behavior are needed to enhance the capability of claims data for smoking-related outcomes research. Copyright © 2018 International Society for Pharmacoeconomics and Outcomes Research (ISPOR). Published by Elsevier Inc. All rights reserved.

  8. Identifying biologically meaningful hot-weather events using threshold temperatures that affect life-history.

    Directory of Open Access Journals (Sweden)

    Susan J Cunningham

    Full Text Available Increases in the frequency, duration and intensity of heat waves are frequently evoked in climate change predictions. However, there is no universal definition of a heat wave. Recent, intense hot weather events have caused mass mortalities of birds, bats and even humans, making the definition and prediction of heat wave events that have the potential to impact populations of different species an urgent priority. One possible technique for defining biologically meaningful heat waves is to use threshold temperatures (T(thresh above which known fitness costs are incurred by species of interest. We set out to test the utility of this technique using T(thresh values that, when exceeded, affect aspects of the fitness of two focal southern African bird species: the southern pied babbler Turdiodes bicolor (T(thresh = 35.5 °C and the common fiscal Lanius collaris (T(thresh = 33 °C. We used these T(thresh values to analyse trends in the frequency, duration and intensity of heat waves of magnitude relevant to the focal species, as well as the annual number of hot days (maximum air temperature > T(thresh, in north-western South Africa between 1961 and 2010. Using this technique, we were able to show that, while all heat wave indices increased during the study period, most rapid increases for both species were in the annual number of hot days and in the maximum intensity (and therefore intensity variance of biologically meaningful heat waves. Importantly, we also showed that warming trends were not uniform across the study area and that geographical patterns in warming allowed both areas of high risk and potential climate refugia to be identified. We discuss the implications of the trends we found for our focal species, and the utility of the T(thresh technique as a conservation tool.

  9. Patient Centred Systems: Techno-Anthropological reflections on the challenges of 'meaningfully engaging' patients within health informatics research.

    Science.gov (United States)

    Wong, Ming-Chao; Almond, Helen; Cummings, Elizabeth; Roehrer, Erin; Showell, Chris; Turner, Paul

    2015-01-01

    This chapter explores how Techno-Anthropology can contribute to more explicitly professional and ethically responsible reflections on the socio-technical practices involved in meaningfully engaging patients in health informatics research. The chapter draws on insights from health informatics research projects focused on chronic disease and self-management conducted in Tasmania during the last 10 years. Through these projects the paper explores three topics of relevance to 'meaningful engagement' with patients: (i) Patient Self-Management and Chronic Disease (ii) Patients as Users in Health Informatics research, and, (iii) Evaluations of outcomes in Health and Health Informatics Interventions. Techno-Anthropological reflections are then discussed through the concepts of liminality, polyphony and power. This chapter argues that beyond its contribution to methodology, an important role for Techno-Anthropology in patient centred health informatics research may be its capacity to support new ways of conceptualising and critically reflecting on the construction and mediation of patients' needs, values and perspectives.

  10. Job enrichment: creating meaningful career development opportunities for nurses.

    Science.gov (United States)

    Duffield, Christine; Baldwin, Richard; Roche, Michael; Wise, Sarah

    2014-09-01

    This paper presents an evaluation of a career development policy in South Australia which increased the number of senior staff nurse positions and provided senior registered nurses with time away from clinical duties to undertake agreed projects. We use Kanter's model of structural power and commitment theory to understand the dimensions of this policy. Development strategies for experienced staff who wish to remain at the bedside are needed, especially in smaller health services with limited opportunities for horizontal or vertical mobility. Face-to-face semistructured interviews were conducted with 54 senior staff nurses who participated in the career structure arrangements. The policy enhanced the structure of opportunity in three ways: by increasing the number of senior staff nurse positions, the ladder steps were improved; undertaking strategic projects developed new skills; and the job enrichment approach facilitated time out from the immediate pressures of ward work and challenged nurses in a different way. Through job enrichment, South Australia has found a novel way of providing meaningful career development opportunities for experienced nurses. Methods of job enrichment need to be considered as part of career development policy, especially where movement between clinical facilities is limited and staff wish to remain at the bedside. © 2013 John Wiley & Sons Ltd.

  11. Establishing meaningful cut points for online user ratings.

    Science.gov (United States)

    Hirschfeld, Gerrit; Thielsch, Meinald T

    2015-01-01

    Subjective perceptions of websites can be reliably measured with questionnaires. But it is unclear how such scores should be interpreted in practice, e.g. is an aesthetics score of 4 points on a seven-point-scale satisfactory? The current paper introduces a receiver-operating characteristic (ROC)-based methodology to establish meaningful cut points for the VisAWI (visual aesthetics of websites inventory) and its short form the VisAWI-S. In two studies we use users' global ratings (UGRs) and website rankings as anchors. A total of 972 participants took part in the studies which yielded similar results. First, one-item UGRs correlate highly with the VisAWI. Second, cut points on the VisAWI reliably differentiate between sites that are perceived as attractive versus unattractive. Third, these cut points are variable, but only within a certain range. Together the research presented here establishes a score of 4.5 on the VisAWI which is a reasonable goal for website designers and highlights the utility of the ROC methodology to derive relevant scores for rating scales.

  12. Redefining meaningful age groups in the context of disease.

    Science.gov (United States)

    Geifman, Nophar; Cohen, Raphael; Rubin, Eitan

    2013-12-01

    Age is an important factor when considering phenotypic changes in health and disease. Currently, the use of age information in medicine is somewhat simplistic, with ages commonly being grouped into a small number of crude ranges reflecting the major stages of development and aging, such as childhood or adolescence. Here, we investigate the possibility of redefining age groups using the recently developed Age-Phenome Knowledge-base (APK) that holds over 35,000 literature-derived entries describing relationships between age and phenotype. Clustering of APK data suggests 13 new, partially overlapping, age groups. The diseases that define these groups suggest that the proposed divisions are biologically meaningful. We further show that the number of different age ranges that should be considered depends on the type of disease being evaluated. This finding was further strengthened by similar results obtained from clinical blood measurement data. The grouping of diseases that share a similar pattern of disease-related reports directly mirrors, in some cases, medical knowledge of disease-age relationships. In other cases, our results may be used to generate new and reasonable hypotheses regarding links between diseases.

  13. Contributions of meaningful experiences gatherings to artistic education field

    Directory of Open Access Journals (Sweden)

    Bernardo Bustamante Cardona

    2012-06-01

    Full Text Available This article shows a theoretical approach to and a description of some contributions of a work of transformation of educational and sociocultural reality carried out by a group of people and institutions, among which are San Buenaventura University, Antioquia Museum, Ediarte Inc. and Antioquia University. Such intervention aims at contributing to the improvement of Artistic Education quality in Antioquia and the nation. In order to understand the significance of these Gatherings, a short historical framework is explained in which global and regional processes of academic activities having an impact on the structure of the Artistic Education field are pointed out. Likewise, some perspectives in the definition of artistic education are tackled and then a definition of Pierre Bourdieu´s concept of fieldis presented. Therefore, Meaningful Experiences Gatherings in Artistic Education (MEGAE are presented and the three first gatherings are described. Finally, it is shown the panorama of the contributions of the gatherings both in the theoretical formulation and relational structure of the field.

  14. Do family physicians electronic health records support meaningful use?

    Science.gov (United States)

    Peterson, Lars E; Blackburn, Brenna; Ivins, Douglas; Mitchell, Jason; Matson, Christine; Phillips, Robert L

    2015-03-01

    Spurred by government incentives, the use of electronic health records (EHRs) in the United States has increased; however, whether these EHRs have the functionality necessary to meet meaningful use (MU) criteria remains unknown. Our objective was to characterize family physician access to MU functionality when using a MU-certified EHR. Data were obtained from a convenience survey of family physicians accessing their American Board of Family Medicine online portfolio in 2011. A brief survey queried MU functionality. We used descriptive statistics to characterize the responses and bivariate statistics to test associations between MU and patient communication functions by presence of a MU-certified EHR. Out of 3855 respondents, 60% reported having an EHR that supports MU. Physicians with MU-certified EHRs were more likely than physicians without MU-certified EHRs to report patient registry activities (49.7% vs. 32.3%, p-valuevs. 56.4%, p-valuecommunication abilities were low regardless of EHR capabilities. Family physicians with MU-certified EHRs are more likely to report MU functionality; however, a sizeable minority does not report MU functions. Many family physicians with MU-certified EHRs may not successfully meet the successively stringent MU criteria and may face significant upgrade costs to do so. Cross sectional survey. Copyright © 2014 Elsevier Inc. All rights reserved.

  15. Possibilities of creating meaningful encounters in anesthesia nursing

    DEFF Research Database (Denmark)

    Aagaard, Karin

    Anesthesia nursing is performed in a highly technological environment with restricted time for interaction with patients. Patients are in a vulnerable position, which can be characterized by anxiety regarding the anesthetic and surgical procedure. The bedrock of effective nursing care is to facil......Anesthesia nursing is performed in a highly technological environment with restricted time for interaction with patients. Patients are in a vulnerable position, which can be characterized by anxiety regarding the anesthetic and surgical procedure. The bedrock of effective nursing care...... of nursing. In this dissertation, focused ethnography is used to explore the interactions between patients and nurse anesthetists before general anesthesia. Moreover, it will explore the professional identity of nurse anesthetists, in relation to the situation of preparing patients for general anesthesia....... A micro-substantive theory is developed regarding the opportunities for creating meaningful encounters between patients and nurse anesthetists. The theory is based on three dominant motivations for interaction in anesthesia nursing. The context of care is not committed and responsive to the core elements...

  16. Kinetic parameters for source driven systems

    International Nuclear Information System (INIS)

    Dulla, S.; Ravetto, P.; Carta, M.; D'Angelo, A.

    2006-01-01

    The definition of the characteristic kinetic parameters of a subcritical source-driven system constitutes an interesting problem in reactor physics with important consequences for practical applications. Consistent and physically meaningful values of the parameters allow to obtain accurate results from kinetic simulation tools and to correctly interpret kinetic experiments. For subcritical systems a preliminary problem arises for the adoption of a suitable weighting function to be used in the projection procedure to derive a point model. The present work illustrates a consistent factorization-projection procedure which leads to the definition of the kinetic parameters in a straightforward manner. The reactivity term is introduced coherently with the generalized perturbation theory applied to the source multiplication factor ks, which is thus given a physical role in the kinetic model. The effective prompt lifetime is introduced on the assumption that a neutron generation can be initiated by both the fission process and the source emission. Results are presented for simplified configurations to fully comprehend the physical features and for a more complicated highly decoupled system treated in transport theory. (authors)

  17. High value of the radiobiological parameter Dq correlates to expression of the transforming growth factor beta type II receptor in a panel of small cell lung cancer cell lines

    DEFF Research Database (Denmark)

    Hougaard, S; Krarup, M; Nørgaard, P

    1998-01-01

    Our panel of SCLC cell lines have previously been examined for their radiobiological characteristics and sensitivity to treatment with TGF beta 1. In this study we examined the possible correlations between radiobiological parameters and the expression of the TGF beta type II receptor (TGF beta......-rII). We have, in other studies, shown that the presence of TGF beta-rII was mandatory for transmitting the growth inhibitory effect of TGF beta. The results showed a statistically significant difference in Dq, i.e. the shoulder width of the survival curve, between cell lines expressing TGF beta......-rII and cell lines which did not express the receptor (P = 0.01). Cell lines expressing TGF beta-rII had a high Dq-value. TGF beta-rII expression did not correlate with any other radiobiological parameters. We suggest that an intact growth inhibitory pathway mediated by the TGF beta-rII may have a significant...

  18. Is the diagnostic threshold for bulimia nervosa clinically meaningful?

    Science.gov (United States)

    Chapa, Danielle A N; Bohrer, Brittany K; Forbush, Kelsie T

    2018-01-01

    The DSM-5 differentiates full- and sub-threshold bulimia nervosa (BN) according to average weekly frequencies of binge eating and inappropriate compensatory behaviors. This study was the first to evaluate the modified frequency criterion for BN published in the DSM-5. The purpose of this study was to test whether community-recruited adults (N=125; 83.2% women) with current full-threshold (n=77) or sub-threshold BN (n=48) differed in comorbid psychopathology and eating disorder (ED) illness duration, symptom severity, and clinical impairment. Participants completed the Clinical Impairment Assessment and participated in semi-structured clinical interviews of ED- and non-ED psychopathology. Differences between the sub- and full-threshold BN groups were assessed using MANOVA and Chi-square analyses. ED illness duration, age-of-onset, body mass index (BMI), alcohol and drug misuse, and the presence of current and lifetime mood or anxiety disorders did not differ between participants with sub- and full-threshold BN. Participants with full-threshold BN had higher levels of clinical impairment and weight concern than those with sub-threshold BN. However, minimal clinically important difference analyses suggested that statistically significant differences between participants with sub- and full-threshold BN on clinical impairment and weight concern were not clinically significant. In conclusion, sub-threshold BN did not differ from full-threshold BN in clinically meaningful ways. Future studies are needed to identify an improved frequency criterion for BN that better distinguishes individuals in ways that will more validly inform prognosis and effective treatment planning for BN. Copyright © 2017 Elsevier Ltd. All rights reserved.

  19. Method of integral values for measuring the heat conductivity and other parameter of materials up to temperatures of 2000 Kelvin; Integralwertverfahren zur Messung der Waermeleiffaehigkeit und anderer Stoffwerte bis zu Temperaturen von 2000 Kelvin

    Energy Technology Data Exchange (ETDEWEB)

    Neumann, Manfred

    1974-06-15

    For the development of new reactor materials and nuclear fuels, it is important to measure the heat conductivity of the materials up to high temperatures. Performing the measurements several difficulties arise. A method which avoids most of the measuring problems has been developed and used to measure the heat conductivity of graphite and uranium carbonidrides. The method is based on measuring a set of integral values of the heat conductivity over relatively large temperature intervals and on evaluating the temperature curve of the heat conductivity by a computer program. Further parameters of the materials as electrical conductivity and thermal expansion can be measured simultaneously.

  20. Nutritive value, growth performance and haematological parameters ...

    African Journals Online (AJOL)

    Twelve West African dwarf sheep, aged between 6 to 8 months and weighing 9 to 10.5 kg were randomly allocated to four treatments consisting of ensiled pineapple fruit waste and cassava root meal (CRM+PFW); sun-dried pineapple fruit waste (PFW); ensiled cassava peels and pineapple fruit waste (CP+PFW); cassava ...

  1. A novel summary report of colonoscopy: timeline visualization providing meaningful colonoscopy video information.

    Science.gov (United States)

    Cho, Minwoo; Kim, Jee Hyun; Kong, Hyoun Joong; Hong, Kyoung Sup; Kim, Sungwan

    2018-05-01

    The colonoscopy adenoma detection rate depends largely on physician experience and skill, and overlooked colorectal adenomas could develop into cancer. This study assessed a system that detects polyps and summarizes meaningful information from colonoscopy videos. One hundred thirteen consecutive patients had colonoscopy videos prospectively recorded at the Seoul National University Hospital. Informative video frames were extracted using a MATLAB support vector machine (SVM) model and classified as bleeding, polypectomy, tool, residue, thin wrinkle, folded wrinkle, or common. Thin wrinkle, folded wrinkle, and common frames were reanalyzed using SVM for polyp detection. The SVM model was applied hierarchically for effective classification and optimization of the SVM. The mean classification accuracy according to type was over 93%; sensitivity was over 87%. The mean sensitivity for polyp detection was 82.1%, and the positive predicted value (PPV) was 39.3%. Polyps detected using the system were larger (6.3 ± 6.4 vs. 4.9 ± 2.5 mm; P = 0.003) with a more pedunculated morphology (Yamada type III, 10.2 vs. 0%; P < 0.001; Yamada type IV, 2.8 vs. 0%; P < 0.001) than polyps missed by the system. There were no statistically significant differences in polyp distribution or histology between the groups. Informative frames and suspected polyps were presented on a timeline. This summary was evaluated using the system usability scale questionnaire; 89.3% of participants expressed positive opinions. We developed and verified a system to extract meaningful information from colonoscopy videos. Although further improvement and validation of the system is needed, the proposed system is useful for physicians and patients.

  2. Taking a leap of faith: Meaningful participation of people with experiences of homelessness in solutions to address homelessness

    Directory of Open Access Journals (Sweden)

    Trudy Laura Norman

    2015-12-01

    Full Text Available Participation of people with experiences of homelessness is critical to the development of meaningful strategies to end homelessness. The purpose of this study was to gain insights from people who have been homeless in a mid-sized Canadian city, as to strategies that facilitate meaningful participation in solutions to end homelessness. Within an overarching framework of collaborative research, we collected data through seven focus groups and employed interpretive description as our approach to data analysis. In our analysis, we identified both exclusionary and inclusionary forces that impact participation. Exclusionary forces included being ‘caught in the homelessness industry’, ‘homelessness is a full time job’ and facing stigma/discrimination that make participation a ‘leap of faith’. Inclusionary forces included earning respect and building trust to address unequal power relations, and restoring often ‘taken for granted’ social relations. Specific strategies to enhance participation include listening, valuing skills and stories, and supporting advocacy efforts. The study findings illuminate ways in which power imbalances are lived out in the daily lives of people who experience homelessness, as well as mitigating forces that provide direction as to strategies for addressing power inequities that seek to make participation and social inclusion meaningful. Keywords: homelessness, social policy, social exclusion, social inclusion, advocacy

  3. The Spatial Relationship between Apparent Diffusion Coefficient and Standardized Uptake Value of 18F-Fluorodeoxyglucose Has a Crucial Influence on the Numeric Correlation of Both Parameters in PET/MRI of Lung Tumors.

    Science.gov (United States)

    Sauter, Alexander W; Stieltjes, Bram; Weikert, Thomas; Gatidis, Sergios; Wiese, Mark; Klarhöfer, Markus; Wild, Damian; Lardinois, Didier; Bremerich, Jens; Sommer, Gregor

    2017-01-01

    The minimum apparent diffusion coefficient (ADC min ) derived from diffusion-weighted MRI (DW-MRI) and the maximum standardized uptake value (SUV max ) of FDG-PET are markers of aggressiveness in lung cancer. The numeric correlation of the two parameters has been extensively studied, but their spatial interplay is not well understood. After FDG-PET and DW-MRI coregistration, values and location of ADC min - and SUV max -voxels were analyzed. The upper limit of the 95% confidence interval for registration accuracy of sequential PET/MRI was 12 mm, and the mean distance ( D ) between ADC min - and SUV max -voxels was 14.0 mm (average of two readers). Spatial mismatch ( D > 12 mm) between ADC min and SUV max was found in 9/25 patients. A considerable number of mismatch cases (65%) was also seen in a control group that underwent simultaneous PET/MRI. In the entire patient cohort, no statistically significant correlation between SUV max and ADC min was seen, while a moderate negative linear relationship ( r = -0.5) between SUV max and ADC min was observed in tumors with a spatial match ( D ≤ 12 mm). In conclusion, spatial mismatch between ADC min and SUV max is found in a considerable percentage of patients. The spatial connection of the two parameters SUV max and ADC min has a crucial influence on their numeric correlation.

  4. Behavioral meaningful opioidergic stimulation activates kappa receptor gene expression

    International Nuclear Information System (INIS)

    Teodorov, E.; Ferrari, M.F.R.; Fior-Chadi, D.R.; Camarini, R.; Felício, L.F.

    2012-01-01

    The periaqueductal gray (PAG) has been reported to be a location for opioid regulation of pain and a potential site for behavioral selection in females. Opioid-mediated behavioral and physiological responses differ according to the activity of opioid receptor subtypes. The present study investigated the effects of the peripheral injection of the kappa-opioid receptor agonist U69593 into the dorsal subcutaneous region of animals on maternal behavior and on Oprk1 gene activity in the PAG of female rats. Female Wistar rats weighing 200-250 g at the beginning of the study were randomly divided into 2 groups for maternal behavior and gene expression experiments. On day 5, pups were removed at 7:00 am and placed in another home cage that was distant from their mother. Thirty minutes after removing the pups, the dams were treated with U69593 (0.15 mg/kg, sc) or 0.9% saline (up to 1 mL/kg) and after 30 min were evaluated in the maternal behavior test. Latencies in seconds for pup retrieval, grouping, crouching, and full maternal behavior were scored. The results showed that U69593 administration inhibited maternal behavior (P < 0.05) because a lower percentage of U69593 group dams showed retrieval of first pup, retrieving all pups, grouping, crouching and displaying full maternal behavior compared to the saline group. Opioid gene expression was evaluated using real-time reverse-transcription polymerase chain reaction (RT-PCR). A single injection of U69593 increased Oprk1 PAG expression in both virgin (P < 0.05) and lactating female rats (P < 0.01), with no significant effect on Oprm1 or Oprd1 gene activity. Thus, the expression of kappa-opioid receptors in the PAG may be modulated by single opioid receptor stimulation and behavioral meaningful opioidergic transmission in the adult female might occur simultaneously to specific changes in gene expression of kappa-opioid receptor subtype. This is yet another alert for the complex role of the opioid system in female

  5. Behavioral meaningful opioidergic stimulation activates kappa receptor gene expression

    Energy Technology Data Exchange (ETDEWEB)

    Teodorov, E. [Centro de Matemática, Computação e Cognição, Universidade Federal do ABC, São Paulo, SP (Brazil); Ferrari, M.F.R. [Departamento de Genética e Biologia Evolutiva, Instituto de Biociências, Universidade de São Paulo, São Paulo, SP (Brazil); Fior-Chadi, D.R. [Departamento de Fisiologia, Instituto de Biociências, Universidade de São Paulo, São Paulo, SP (Brazil); Camarini, R. [Departamento de Farmacologia, Instituto de Ciências Biomédicas, Universidade de São Paulo, São Paulo, SP (Brazil); Felício, L.F. [Departamento de Patologia, Faculdade de Medicina Veterinária e Zootecnia, Universidade de São Paulo, São Paulo, SP (Brazil)

    2012-06-01

    The periaqueductal gray (PAG) has been reported to be a location for opioid regulation of pain and a potential site for behavioral selection in females. Opioid-mediated behavioral and physiological responses differ according to the activity of opioid receptor subtypes. The present study investigated the effects of the peripheral injection of the kappa-opioid receptor agonist U69593 into the dorsal subcutaneous region of animals on maternal behavior and on Oprk1 gene activity in the PAG of female rats. Female Wistar rats weighing 200-250 g at the beginning of the study were randomly divided into 2 groups for maternal behavior and gene expression experiments. On day 5, pups were removed at 7:00 am and placed in another home cage that was distant from their mother. Thirty minutes after removing the pups, the dams were treated with U69593 (0.15 mg/kg, sc) or 0.9% saline (up to 1 mL/kg) and after 30 min were evaluated in the maternal behavior test. Latencies in seconds for pup retrieval, grouping, crouching, and full maternal behavior were scored. The results showed that U69593 administration inhibited maternal behavior (P < 0.05) because a lower percentage of U69593 group dams showed retrieval of first pup, retrieving all pups, grouping, crouching and displaying full maternal behavior compared to the saline group. Opioid gene expression was evaluated using real-time reverse-transcription polymerase chain reaction (RT-PCR). A single injection of U69593 increased Oprk1 PAG expression in both virgin (P < 0.05) and lactating female rats (P < 0.01), with no significant effect on Oprm1 or Oprd1 gene activity. Thus, the expression of kappa-opioid receptors in the PAG may be modulated by single opioid receptor stimulation and behavioral meaningful opioidergic transmission in the adult female might occur simultaneously to specific changes in gene expression of kappa-opioid receptor subtype. This is yet another alert for the complex role of the opioid system in female

  6. Behavioral meaningful opioidergic stimulation activates kappa receptor gene expression

    Directory of Open Access Journals (Sweden)

    E. Teodorov

    2012-10-01

    Full Text Available The periaqueductal gray (PAG has been reported to be a location for opioid regulation of pain and a potential site for behavioral selection in females. Opioid-mediated behavioral and physiological responses differ according to the activity of opioid receptor subtypes. The present study investigated the effects of the peripheral injection of the kappa-opioid receptor agonist U69593 into the dorsal subcutaneous region of animals on maternal behavior and on Oprk1 gene activity in the PAG of female rats. Female Wistar rats weighing 200-250 g at the beginning of the study were randomly divided into 2 groups for maternal behavior and gene expression experiments. On day 5, pups were removed at 7:00 am and placed in another home cage that was distant from their mother. Thirty minutes after removing the pups, the dams were treated with U69593 (0.15 mg/kg, sc or 0.9% saline (up to 1 mL/kg and after 30 min were evaluated in the maternal behavior test. Latencies in seconds for pup retrieval, grouping, crouching, and full maternal behavior were scored. The results showed that U69593 administration inhibited maternal behavior (P < 0.05 because a lower percentage of kappa group dams showed retrieval of first pup, retrieving all pups, grouping, crouching and displaying full maternal behavior compared to the saline group. Opioid gene expression was evaluated using real-time reverse-transcription polymerase chain reaction (RT-PCR. A single injection of U69593 increased Oprk1 PAG expression in both virgin (P < 0.05 and lactating female rats (P < 0.01, with no significant effect on Oprm1 or Oprd1 gene activity. Thus, the expression of kappa-opioid receptors in the PAG may be modulated by single opioid receptor stimulation and behavioral meaningful opioidergic transmission in the adult female might occur simultaneously to specific changes in gene expression of kappa-opioid receptor subtype. This is yet another alert for the complex role of the opioid system in

  7. Can the 'African household' be presented meaningfully in large ...

    African Journals Online (AJOL)

    ANBR

    population groups (referring to the white, Indian, coloured and black racial categories in South Africa). .... varying, and sometimes conflicting, values in mind. Socioeconomic aspects .... amongst various European and North American countries.

  8. Are climatological correlations with the Hale double sunspot cycle meaningful

    International Nuclear Information System (INIS)

    Goldberg, R.A.; Herman, J.R.

    1975-09-01

    A sunspot cycle which may have been subject to a predicted phase reversal between 1800 and 1880 A.D. is discussed. Several climatological parameters normally correlated with this cycle are examined and do not exhibit a corresponding phase reversal during this period. It is proposed that this apparent discrepency can be resolved by suitable observations during the upcoming half decade

  9. Nitrogen-use-efficiency: a biologically meaningful definition?

    NARCIS (Netherlands)

    Berendse, F.; Aerts, R.

    1987-01-01

    A parameter to measure the efficiency of nitrogen use should include 1) the mean residence time of the N in the plant, ie the period during which the absorbed N can be used for C-fixation; and 2) the instantaneous rate of C-fixation per unit of N in the plant. It is essential to distinguish between

  10. Merit-Based Incentive Payment System: Meaningful Changes in the Final Rule Brings Cautious Optimism.

    Science.gov (United States)

    Manchikanti, Laxmaiah; Helm Ii, Standiford; Calodney, Aaron K; Hirsch, Joshua A

    2017-01-01

    The Medicare Access and CHIP Reauthorization Act of 2015 (MACRA) eliminated the flawed Sustainable Growth Rate (SGR) act formula - a longstanding crucial issue of concern for health care providers and Medicare beneficiaries. MACRA also included a quality improvement program entitled, "The Merit-Based Incentive Payment System, or MIPS." The proposed rule of MIPS sought to streamline existing federal quality efforts and therefore linked 4 distinct programs into one. Three existing programs, meaningful use (MU), Physician Quality Reporting System (PQRS), value-based payment (VBP) system were merged with the addition of Clinical Improvement Activity category. The proposed rule also changed the name of MU to Advancing Care Information, or ACI. ACI contributes to 25% of composite score of the four programs, PQRS contributes 50% of the composite score, while VBP system, which deals with resource use or cost, contributes to 10% of the composite score. The newest category, Improvement Activities or IA, contributes 15% to the composite score. The proposed rule also created what it called a design incentive that drives movement to delivery system reform principles with the inclusion of Advanced Alternative Payment Models (APMs).Following the release of the proposed rule, the medical community, as well as Congress, provided substantial input to Centers for Medicare and Medicaid Services (CMS),expressing their concern. American Society of Interventional Pain Physicians (ASIPP) focused on 3 important aspects: delay the implementation, provide a 3-month performance period, and provide ability to submit meaningful quality measures in a timely and economic manner. The final rule accepted many of the comments from various organizations, including several of those specifically emphasized by ASIPP, with acceptance of 3-month reporting period, as well as the ability to submit non-MIPS measures to improve real quality and make the system meaningful. CMS also provided a mechanism for

  11. Valuing Essays: Essaying Values

    Science.gov (United States)

    Badley, Graham

    2010-01-01

    The essay regularly comes under attack. It is criticised for being rigidly linear rather than flexible and reflective. I first challenge this view by examining reasons why the essay should be valued as an important genre. Secondly, I propose that in using the essay form students and academics necessarily exemplify their own critical values. Essays…

  12. Are estimates of meaningful decline in mobility performance consistent among clinically important subgroups? (Health ABC Study).

    NARCIS (Netherlands)

    Perera, S.; Studenski, S.; Newman, A.; Simonsick, E.; Harris, T.; Schwartz, A.; Visser, M.

    2014-01-01

    Background: Meaningful change criteria help determine if function has improved or declined, but their magnitudes may vary across clinically relevant subgroups. We estimate meaningful decline in four common measures of physical performance in subgroups of older adults based on initial performance,

  13. Development of an Assessment Tool to Measure Students' Meaningful Learning in the Undergraduate Chemistry Laboratory

    Science.gov (United States)

    Galloway, Kelli R.; Bretz, Stacey Lowery

    2015-01-01

    Research on learning in the undergraduate chemistry laboratory necessitates an understanding of students' perspectives of learning. Novak's Theory of Meaningful Learning states that the cognitive (thinking), affective (feeling), and psychomotor (doing) domains must be integrated for meaningful learning to occur. The psychomotor domain is the…

  14. Meaningful Experiences in Physical Education and Youth Sport: A Review of the Literature

    Science.gov (United States)

    Beni, Stephanie; Fletcher, Tim; Ní Chróinín, Déirdre

    2017-01-01

    The purpose of this research is to review the literature about young people's meaningful experiences in physical education and youth sport. We reviewed 50 empirical peer-reviewed articles published in English since 1987. Five themes were identified as central influences to young people's meaningful experiences in physical education and sport:…

  15. Relationship between attachment to God and meaningful life parents of mentally retarded children in Zahedan city

    Directory of Open Access Journals (Sweden)

    H Jenaabadi

    2014-07-01

    Conclusion: Given a significant positive correlation between appeal to God and meaningful life, it is suggested including spirituality therapy sessions and teaching religious coping methods to reduce stress and thus make meaningful life in these parents by welfare, education of exceptional children, and radio and television organizations.

  16. A Continuum of Learning: From Rote Memorization to Meaningful Learning in Organic Chemistry

    Science.gov (United States)

    Grove, Nathaniel P.; Bretz, Stacey Lowery

    2012-01-01

    The Assimilation Theory of Ausubel and Novak has typically been used in the research literature to describe two extremes to learning chemistry: meaningful learning "versus" rote memorization. It is unlikely, however, that such discrete categories of learning exist. Rote and meaningful learning, rather, are endpoints along a continuum of…

  17. Meaningful Watershed Experiences for Middle and High School Students

    Science.gov (United States)

    Landry, Melinda; Smith, Cynthia; Greene, Joy

    2014-05-01

    Prince William County Public Schools and George Mason University in Virginia, USA, partnered to provide Meaningful Watershed Educational Experiences (MWEEs) for over 25,000 middle and high school students (11-18 year olds) across 34 schools. This school district, situated in a rapidly growing region 55 km southwest of Washington DC, has over 82,000 K-12 students. As native forest cover has been replaced with farming and urbanization, water quality has significantly degraded in the 166,534 km2 Chesapeake Bay watershed. This project was designed to increase student awareness of their impact on the land and waters of the largest estuary in the United States. MWEE is a long-term comprehensive project that incorporates a classroom preparation phase, a hands-on outdoor field investigation, and a reflection and data-sharing component. Training and technical assistance enhances the capacity of teachers of 6th grade, high school Earth Science and Environmental Science to deliver MWEEs which includes schoolyard stewardship, inquiry driven field study, use of hand-held technology and computer based mapping and analysis, project sharing and outreach. George Mason University researchers worked closely with K-12 science educators to create a comprehensive watershed-focused curriculum. Graduate and undergraduate students with strong interests in environmental science and education were trained to deliver the field investigation component of the MWEE. Representative teachers from each school were provided 3 days of professional development and were responsible for the training of their school's science education team. A comprehensive curriculum provided teachers with activities and tools designed to enhance students' mastery of state science objectives. Watershed concepts were used as the unifying theme to support student understanding of curriculum and STEM objectives including: scientific investigation, data collection and communication, chemistry, energy, erosion, human

  18. To Engage Students, Give Them Meaningful Choices in the Classroom

    Science.gov (United States)

    Parker, Frieda; Novak, Jodie; Bartell, Tonya

    2017-01-01

    Providing students with choice can be a powerful means of supporting student engagement. However, not all choice opportunities lead to improved student engagement. Teachers can increase the likelihood that students will value choice by analyzing how students associate feelings of autonomy, competence, and relatedness with the choice provided them.…

  19. Negative emotions and the meaningful sides of media entertainment

    NARCIS (Netherlands)

    Oliver, M. B.; Bartsch, A.; Hartmann, T.; Parrott, G.

    2014-01-01

    This unique volume brings together state-of-the-art research showing the value of emotions that many believe to be undesirable. Leading investigators explore the functions and benefits of sadness, anxiety, anger, embarrassment, shame, guilt, jealousy, and envy. The role of these emotions in social

  20. Connecting Meaningful Music and Experiences in a Multicultural, Multimusical Classroom

    Science.gov (United States)

    Kelly, Steven N.; Van Weelden, Kimberly

    2004-01-01

    It is important to realize that students encompass a vast array of American musical cultures and the values they represent. The impact of this diversity can be seen in the influence music has on the self-image that many students have developed. Clothing, hair styles, makeup, tattoos, and body piercings, as well as in-and out-of-school social…

  1. Analysis of the Impact of Double Shot Peening on the Value of Roughness Parameter and Distribution of Stresses in the RSA 501 Alloy (Al Mg5 Mn1 Sc0.8 Zr0.4

    Directory of Open Access Journals (Sweden)

    Paulina Byczkowska

    2017-09-01

    Full Text Available The bead blasting process is widespread in both the automotive and aerospace industry and is performed in order to improve the fatigue strength of various components. Bead blasting is a cold plastic forming process during which the surface of the material processed is hit by small, hard particles consisting of steel pellets, bearing balls or glass beads. It increases the hardness of the outer layer and establishes compression stresses inside it, which is why this processing is often used to improve fatigue strength. Contrary to other peening methods, bead blasting does not result in a reduction in the height of the processed surface’s unevenness in most cases. Shot peening changes the residual tensile stresses into residual compression stresses, thanks to which, the lifetime of the parts processed is extended and their carrying capacity is increased. The double shot peening process proposed by the authors consists in a two-stage bead blasting process. The first stage consists in blasting with round cast steel pellets, pellets cut from wire or cast iron pellets. During the second stage the same samples underwent glass bead blasting. The tests conducted on the RSA-501 aluminum alloy indicate that as a result of the processing medium’s impact in the form of glass beads or pellets of different diameter and shape, a permanent plastic deformation of the material surface occurs. On the basis of the obtained results it is possible to infer that the choice of parameters of both conventional shot peening and the double shot peening determine the impact thereof on the material’s mechanical properties. Thanks to the application of the double shot peening process there is a noticeable decrease in value of the Ra parameter, by about 40% on average. When analyzing the compressive stress results it is possible to state that after the first blasting process the value of stress was increasing when moving deeply into the sample from its surface, while after

  2. Meaningful Change Scores in the Knee Injury and Osteoarthritis Outcome Score in Patients Undergoing Anterior Cruciate Ligament Reconstruction

    DEFF Research Database (Denmark)

    Ingelsrud, Lina Holm; Terwee, Caroline B; Terluin, Berend

    2018-01-01

    BACKGROUND: Meaningful change scores in the Knee injury and Osteoarthritis Outcome Score (KOOS) in patients undergoing anterior cruciate ligament (ACL) reconstruction have not yet been established. PURPOSE: To define the minimal important change (MIC) for the KOOS after ACL reconstruction. STUDY...... data for at least one of the KOOS subscales were obtained from 542 (45.3%) participants. Predictive modeling MIC values were 12.1 for the KOOS subscales of Sport and Recreational Function and 18.3 for Knee-Related Quality of Life. These values aid in interpreting within-group improvement over time...... and can be used as responder criteria when comparing groups. The corresponding and much lower values for the subscales of Pain (2.5), Symptoms (-1.2), and Activities of Daily Living (2.4) are the results from patients reporting, on average, only mild problems with these domains preoperatively. Although 4...

  3. Lattice parameter values and phase transitions for the Cu2Cd1-zMnzSnSe4 and Cu2Cd1-zFezSnSe4 alloys

    International Nuclear Information System (INIS)

    Moreno, E.; Quintero, M.; Morocoima, M.; Quintero, E.; Grima, P.; Tovar, R.; Bocaranda, P.; Delgado, G.E.; Contreras, J.E.; Mora, A.E.; Briceno, J.M.; Avila Godoy, R.; Fernandez, J.L.; Henao, J.A.; Macias, M.A.

    2009-01-01

    X-ray powder diffraction measurements and differential thermal analysis (DTA) were made on polycrystalline samples of the Cu 2 Cd 1-z Mn z SnSe 4 and Cu 2 Cd 1-z Fe z SnSe 4 alloy systems. The diffraction patterns were used to show the equilibrium conditions and to derive lattice parameter values. For Cu 2 Cd 0.8 Fe 0.2 SnSe 4 as well as for Cu 2 Cd 0.2 Fe 0.8 SnSe 4 the crystal structures were refined using the Rietveld method. It was found that the internal distortion parameter σ decreases as Cd is replaced by either Mn and/or Fe. For the Cu 2 Cd 1-z Mn z SnSe 4 and Cu 2 Cd 1-z Fe z SnSe 4 alloy systems, only two single solid phase fields, the tetragonal stannite α(I4-bar2m) and the wurtz-stannite δ (Pmn2 1 ) structures were found to occur in the diagram. In addition to the tetragonal stannite α phase extra X-ray diffraction lines due to MnSe and/or FeSe 2 were observed for as grown samples in the range 0.7 < z < 1.0. However, it was found that the amount of the extra phase decreased for the compressed samples.

  4. Managerial strategies to make incentives meaningful and motivating.

    Science.gov (United States)

    Korlén, Sara; Essén, Anna; Lindgren, Peter; Amer-Wahlin, Isis; von Thiele Schwarz, Ulrica

    2017-04-10

    Purpose Policy makers are applying market-inspired competition and financial incentives to drive efficiency in healthcare. However, a lack of knowledge exists about the process whereby incentives are filtered through organizations to influence staff motivation, and the key role of managers is often overlooked. The purpose of this paper is to explore the strategies managers use as intermediaries between financial incentives and the individual motivation of staff. The authors use empirical data from a local case in Swedish specialized care. Design/methodology/approach The authors conducted an exploratory qualitative case study of a patient-choice reform, including financial incentives, in specialized orthopedics in Sweden. In total, 17 interviews were conducted with professionals in managerial positions, representing six healthcare providers. A hypo-deductive, thematic approach was used to analyze the data. Findings The results show that managers applied alignment strategies to make the incentive model motivating for staff. The managers' strategies are characterized by attempts to align external rewards with professional values based on their contextual and practical knowledge. Managers occasionally overruled the financial logic of the model to safeguard patient needs and expressed an interest in having a closer dialogue with policy makers about improvements. Originality/value Externally imposed incentives do not automatically motivate healthcare staff. Managers in healthcare play key roles as intermediaries by aligning external rewards with professional values. Managers' multiple perspectives on healthcare practices and professional culture can also be utilized to improve policy and as a source of knowledge in partnership with policy makers.

  5. Physiological parameters

    International Nuclear Information System (INIS)

    Natera, E.S.

    1998-01-01

    The physiological characteristics of man depend on the intake, metabolism and excretion of stable elements from food, water, and air. The physiological behavior of natural radionuclides and radionuclides from nuclear weapons testing and from the utilization of nuclear energy is believed to follow the pattern of stable elements. Hence information on the normal physiological processes occurring in the human body plays an important role in the assessment of the radiation dose received by man. Two important physiological parameters needed for internal dose determination are the pulmonary function and the water balance. In the Coordinated Research Programme on the characterization of Asian population, five participants submitted data on these physiological characteristics - China, India, Japan, Philippines and Viet Nam. During the CRP, data on other pertinent characteristics such as physical and dietary were simultaneously being collected. Hence, the information on the physiological characteristics alone, coming from the five participants were not complete and are probably not sufficient to establish standard values for the Reference Asian Man. Nonetheless, the data collected is a valuable contribution to this research programme

  6. The journey of primary care practices to meaningful use: a Colorado Beacon Consortium study.

    Science.gov (United States)

    Fernald, Douglas H; Wearner, Robyn; Dickinson, W Perry

    2013-01-01

    The Health Information Technology for Economic and Clinical Health Act of 2009 provides for incentive payments through Medicare and Medicaid for clinicians who implement electronic health records (EHRs) and use this technology meaningfully to improve patient care. There are few comprehensive descriptions of how primary care practices achieve the meaningful use of clinical data, including the formal stage 1 meaningful use requirements. Evaluation of the Colorado Beacon Consortium project included iterative qualitative analysis of practice narratives, provider and staff interviews, and separate focus groups with quality improvement (QI) advisors and staff from the regional health information exchange (HIE). Most practices described significant realignment of practice priorities and aims, which often required substantial education and training of physicians and staff. Re-engineering office processes, data collection protocols, EHRs, staff roles, and practice culture comprised the primary effort and commitment to attest to stage 1 meaningful use and subsequent meaningful use of clinical data. While realizing important benefits, practices bore a significant burden in learning the true capabilities of their EHRs with little effective support from vendors. Attestation was an important initial milestone in the process, but practices faced substantial ongoing work to use their data meaningfully for patient care and QI. Key resources were instrumental to these practices: local technical EHR expertise; collaborative learning mechanisms; and regular contact and support from QI advisors. Meeting the stage 1 requirements for incentives under Medicare and Medicaid meaningful use criteria is the first waypoint in a longer journey by primary care practices to the meaningful use of electronic data to continuously improve the care and health of their patients. The intensive re-engineering effort for stage 1 yielded practice changes consistent with larger practice aims and goals

  7. Significance of periacinar cleftings as supporting criteria in diagnosis of prostatic adenocarcinoma Gleason score-a 7 (3+4 and Gleason score-a 7 (4+3 and their relationship with parameters of predictive value

    Directory of Open Access Journals (Sweden)

    Mijović Milica

    2014-01-01

    Full Text Available Diagnosis of different pathohystological diseases of prostate in the most cases is based on common benignant and malignant characteristics. The presence of periacinar cleftings (PC is an additional criterion favouring prostatic adenocarcinoma. According to the presence and extent of PC, analysed on high power field (400x, glands were classified into 3 groups: group 1-glands without PC or with PC affecting ≤50% of gland circumference; group 2-glands with PC affecting >50% gland circumference in 50% gland circumference in ≥50% examined glands. The aim of our study was to determine the importance of presence of PC in prostatic adenocarcinoma (ADCP of Gleason score 7(3+4 and 7(4+3 and establish the existence of differences in their appearance at ADCP with first and second dominant histological grade 3 and 4 in each different relationship based on correlation analysis of PC and parameters of the predictive value (preoperative value of serum prostate specific antigen, tumor volume, clinical stage and degree of focal neuroendocrine differentiation. The study included 33 ADCP of Gleason score 7, 26 (78.79% ADCP 7(3+4 and 7 (21.21% ADCP 7(4+3. In ADCP Gleason 7(3+4 periacinar cleftings are more common in tumors that are smaller, better differentiated (produce more PSA, which is diagnosed in less advanced clinical stages and showing a less degree of focal neuroendocrine differentiation. In ADCP Gleason 7(4+3 periacinar cleftings are more common in tumors which produce less value of serum PSA (poorly differentiated and in tumors that are diagnosed in advanced clinical stages. Periacinar cleftings are common findings in prostatic adenocarcinoma Gleason score 7(4+3 which are considerd as tumors with worse prognosis. Because of all we can rank PC among the important additional criteria for the diagnosis of adenocarcinoma of the prostate.

  8. Safeguards systems parameters

    International Nuclear Information System (INIS)

    Avenhaus, R.; Heil, J.

    1979-01-01

    In this paper analyses are made of the values of those parameters that characterize the present safeguards system that is applied to a national fuel cycle; those values have to be fixed quantitatively so that all actions of the safeguards authority are specified precisely. The analysis starts by introducing three categories of quantities: The design parameters (number of MBAs, inventory frequency, variance of MUF, verification effort and false-alarm probability) describe those quantities whose values have to be specified before the safeguards system can be implemented. The performance criteria (probability of detection, expected detection time, goal quantity) measure the effectiveness of a safeguards system; and the standards (threshold amount and critical time) characterize the magnitude of the proliferation problem. The means by which the values of the individual design parameters can be determined with the help of the performance criteria; which qualitative arguments can narrow down the arbitrariness of the choice of values of the remaining parameters; and which parameter values have to be fixed more or less arbitrarily, are investigated. As a result of these considerations, which include the optimal allocation of a given inspection effort, the problem of analysing the structure of the safeguards system is reduced to an evaluation of the interplay of only a few parameters, essentially the quality of the measurement system (variance of MUF), verification effort, false-alarm probability, goal quantity and probability of detection

  9. Parameter Estimation

    DEFF Research Database (Denmark)

    Sales-Cruz, Mauricio; Heitzig, Martina; Cameron, Ian

    2011-01-01

    of optimisation techniques coupled with dynamic solution of the underlying model. Linear and nonlinear approaches to parameter estimation are investigated. There is also the application of maximum likelihood principles in the estimation of parameters, as well as the use of orthogonal collocation to generate a set......In this chapter the importance of parameter estimation in model development is illustrated through various applications related to reaction systems. In particular, rate constants in a reaction system are obtained through parameter estimation methods. These approaches often require the application...... of algebraic equations as the basis for parameter estimation.These approaches are illustrated using estimations of kinetic constants from reaction system models....

  10. The Value of Children to Iranian Parents

    Directory of Open Access Journals (Sweden)

    Mohammad Taghi Iman

    2007-05-01

    Full Text Available What do parents feel the value of children might be? Using rational choice theory, the effect of having children was measured by their aggregate social, economic and emotional value. The results show that age, gender, occupation and the experience of having raised a child did not correlate with the value of children. However, marital status, family size, family income and especially religiosity all play a meaningful part in determining the value of children.

  11. Use of Geographically Weighted Regression (GWR Method to Estimate the Effects of Location Attributes on the Residential Property Values

    Directory of Open Access Journals (Sweden)

    Mohd Faris Dziauddin

    2017-07-01

    Full Text Available This study estimates the effect of locational attributes on residential property values in Kuala Lumpur, Malaysia. Geographically weighted regression (GWR enables the use of the local parameter rather than the global parameter to be estimated, with the results presented in map form. The results of this study reveal that residential property values are mainly determined by the property’s physical (structural attributes, but proximity to locational attributes also contributes marginally. The use of GWR in this study is considered a better approach than other methods to examine the effect of locational attributes on residential property values. GWR has the capability to produce meaningful results in which different locational attributes have differential spatial effects across a geographical area on residential property values. This method has the ability to determine the factors on which premiums depend, and in turn it can assist the government in taxation matters.

  12. Meaningfully incorporating staff input to enhance frontline engagement.

    Science.gov (United States)

    Strumwasser, Sarah; Virkstis, Katherine

    2015-04-01

    Nurses play a critical role in care transformation. To achieve transformation, frontline staff must be engaged in their work, committed to their organization's mission, and capable of delivering high-quality care. Data from the Advisory Board Survey Solutions show that nurses are both the least engaged and most disengaged among all frontline staff. To identify the most promising opportunities for driving engagement, researchers from The Advisory Board Company analyzed engagement survey responses from more than 343,000 employees at 575 healthcare organizations. This article describes 3 strategies for addressing 1 of the greatest opportunities identified from the data: ensuring that nurses feel that their ideas and suggestions are valued by the organization.

  13. The Value of Value

    DEFF Research Database (Denmark)

    Sørensen, Asger

    parts of business ethics given prominence to especially one term, namely `value'. The question that interests me is the following: What does the articulation of ethics and morality in terms of values mean for ethics and morality as such. Or, to put the question in a more fashionably way: What......As a social scientist of ethics and morality, Luhmann has noticed the ethical wave that has recently swept across the western world, and states that this particular kind of wave seems to have a wavelength of about one hundred years (cf. Luhmann 1989: 9 ff.). Even though the frequency...... and the regularity of such a phenomenon is both hard to verify and, if true, difficult to explain, it seems fair to say that since the Enlightenment, an approaching fin-de-siecle has brought an increased interest in matters concerning morality and ethics.1 The present peak has in public-political discourse and some...

  14. Inclusion of functional information from perfusion SPECT improves predictive value of dose-volume parameters in lung toxicity outcome after radiotherapy for non-small cell lung cancer: A prospective study

    DEFF Research Database (Denmark)

    Farr, Katherina P; Kallehauge, Jesper F; Møller, Ditte S

    2015-01-01

    for corresponding standard parameters, but they were not significantly different from each other. CONCLUSION: SPECT-based functional parameters were better to predict the risk of RP compared to standard CT-based dose-volume parameters. Functional parameters may be useful to guide radiotherapy planning in order...

  15. Using Community-Based Participatory Research to Investigate Meaningful Prenatal Care Among African American Women.

    Science.gov (United States)

    Nypaver, Cynthia F; Shambley-Ebron, Donna

    2016-11-01

    In the United States, African American babies die more than twice as often as White babies. The cause for this difference remains elusive, yet is likely complex with one factor being inadequate cultural care of pregnant African American women. The purpose of this study was to explore African American women's perspectives of meaningful prenatal care. Community-based participatory research was employed for this study using photovoice. The sample included 11 African American mothers in an urban community in Midwestern United States. Five themes were abstracted from the data: (1) Access to Care; (2) Soul Nourishment; (3) Companionship; (4) Help Me, Teach Me; and (5) The Future. Meaningful prenatal care is influenced by culture. African American women need physical, social, and soulful support to enhance meaningfulness of care during pregnancy. The findings support that meaningfulness of prenatal care for African American women may be enhanced by accessible and uniquely designed, culturally congruent models of prenatal care. © The Author(s) 2015.

  16. Can Ausubel's Theory of Meaningful Learning Become an Alternative to Piagetian Psychology?

    Science.gov (United States)

    Albert, Edna

    1979-01-01

    Discusses Novak's views that Ausubel's meaningful learning can become an alternative to Piagetian psychology and argues that Ausubel does not provide a theory that can be an alternative to Piaget's developmental psychology. (HM)

  17. Meaningful coping with chronic pain: Exploring the interplay between goal violation, meaningful coping strategies and life satisfaction in chronic pain patients.

    Science.gov (United States)

    Dezutter, Jessie; Dewitte, Laura; Thauvoye, Evalyne; Vanhooren, Siebrecht

    2017-02-01

    Trying to cope with chronic pain is a highly demanding and challenging task and pain patients often need to reformulate goals or aspirations due to their pain condition. This goal violation is often related with experienced distress and requires coping processes in order to decrease the distress and stimulate a healthy adaptation. Some scholars, however, argued that in so-called unsolvable or irreparable stressors such as chronic pain, conventional coping strategies like problem-focused coping might not be the most adaptive option. In these situations, meaningful coping strategies attempting to transform the meaning of the stressful experience would be more accurate. In this study, we aim to test if goal violation triggers meaningful coping strategies over time and whether engagement in these meaningful coping strategies result in improved life satisfaction, as an indicator of adaptation. A longitudinal three wave study in a sample of paint patients (n = 125) tests whether goal violation triggers positive reappraisal and downward comparison, two possible meaningful coping strategies. The study furthermore tests if engagement in these strategies results in a better adaptation to the pain condition, reflected in higher life satisfaction. Results partially supported our hypotheses by pointing to the benevolent role of downward comparison on life satisfaction via decreased goal violation of pain patients. Our findings however did also show that positive reappraisal predicted lower life satisfaction via increased levels of appraised goal violation which questions the role of positive reappraisal as a genuine meaningful coping strategy. Implications and limitations are discussed. © 2016 Scandinavian Psychological Associations and John Wiley & Sons Ltd.

  18. Audio-Visual and Meaningful Semantic Context Enhancements in Older and Younger Adults.

    Directory of Open Access Journals (Sweden)

    Kirsten E Smayda

    Full Text Available Speech perception is critical to everyday life. Oftentimes noise can degrade a speech signal; however, because of the cues available to the listener, such as visual and semantic cues, noise rarely prevents conversations from continuing. The interaction of visual and semantic cues in aiding speech perception has been studied in young adults, but the extent to which these two cues interact for older adults has not been studied. To investigate the effect of visual and semantic cues on speech perception in older and younger adults, we recruited forty-five young adults (ages 18-35 and thirty-three older adults (ages 60-90 to participate in a speech perception task. Participants were presented with semantically meaningful and anomalous sentences in audio-only and audio-visual conditions. We hypothesized that young adults would outperform older adults across SNRs, modalities, and semantic contexts. In addition, we hypothesized that both young and older adults would receive a greater benefit from a semantically meaningful context in the audio-visual relative to audio-only modality. We predicted that young adults would receive greater visual benefit in semantically meaningful contexts relative to anomalous contexts. However, we predicted that older adults could receive a greater visual benefit in either semantically meaningful or anomalous contexts. Results suggested that in the most supportive context, that is, semantically meaningful sentences presented in the audiovisual modality, older adults performed similarly to young adults. In addition, both groups received the same amount of visual and meaningful benefit. Lastly, across groups, a semantically meaningful context provided more benefit in the audio-visual modality relative to the audio-only modality, and the presence of visual cues provided more benefit in semantically meaningful contexts relative to anomalous contexts. These results suggest that older adults can perceive speech as well as younger

  19. Pengaruh Job Enrichment terhadap Employee Engagement melalui Psychological Meaningfulness sebagai Mediator

    OpenAIRE

    Sungkit, Flavia Norpina; Meiyanto, IJK Sito

    2015-01-01

    The purpose of the study is to investigate the influence of job enrichment toward employee engagement through psychological meaningfulness as the mediator. Research design used is a cross-sectional study of 112 employees. Data is analyzed by multiple linear regression analysis. Result shows job enrichment is able to influence employee engagement significantly through psychological meaningfulness as the mediator. The p=0,000 with significance level 0,05. The sig F change shows 0,006, which is

  20. Driving Meaningful Adaptation Action through an Adaptation Market Mechanism

    Energy Technology Data Exchange (ETDEWEB)

    Butzengeiger-Geyer, Sonja; Koehler, Michel; Michaelowa, Axel

    2011-07-01

    Approaches and criteria for allocating adaptation funds vary significantly among current sources - UN-backed funds and bilateral cooperation - and to some extent lack transparency and consistency. Such funding risks being spent in a haphazard way that repeats many of the mistakes made in development assistance over the past decades. An Adaptation Market Mechanism (AMM) could contribute to efficient allocation of adaptation funds, promote adaptation activities by private and public actors through additional financial incentives, and raise additional and reliable adaptation money. This would help to avoid future public criticism of the effectiveness and efficiency of spending adaptation funding.The proposed AMM would specify mandatory adaptation targets, on international, regional or domestic level. Participants who achieve their targets either by generating adaptation units or by buying them in the market would incentivize private, commercial and institutional actors to develop adaptation projects that create verified adaptation units. A universally accepted and verifiable trading unit applicable to all types of adaptation activities would help to maximize the cost reduction potential for the AMM. We suggest applying net present value (NPV) for property saved; Disability Adjusted Life Years Saved (DALYS) for health benefits; and potentially a separate unit to consider the environmental benefits of an adaptation activity.(Author)

  1. Finding Meaningful Roles for Scientists in science Education Reform

    Science.gov (United States)

    Evans, Brenda

    Successful efforts to achieve reform in science education require the active and purposeful engagement of professional scientists. Working as partners with teachers, school administrators, science educators, parents, and other stakeholders, scientists can make important contributions to the improvement of science teaching and learning in pre-college classrooms. The world of a practicing university, corporate, or government scientist may seem far removed from that of students in an elementary classroom. However, the science knowledge and understanding of all future scientists and scientifically literate citizens begin with their introduction to scientific concepts and phenomena in childhood and the early grades. Science education is the responsibility of the entire scientific community and is not solely the responsibility of teachers and other professional educators. Scientists can serve many roles in science education reform including the following: (1) Science Content Resource, (2) Career Role Model, (3) Interpreter of Science (4) Validator for the Importance of Learning Science and Mathematics, (5) Champion of Real World Connections and Value of Science, (6) Experience and Access to Funding Sources, (7) Link for Community and Business Support, (8) Political Supporter. Special programs have been developed to assist scientists and engineers to be effective partners and advocates of science education reform. We will discuss the rationale, organization, and results of some of these partnership development programs.

  2. Cluster Analysis of an International Pressure Pain Threshold Database Identifies 4 Meaningful Subgroups of Adults With Mechanical Neck Pain

    DEFF Research Database (Denmark)

    Walton, David M; Kwok, Timothy S H; Mehta, Swati

    2017-01-01

    OBJECTIVE: To determine pressure pain detection threshold (PPDT) related phenotypes of individuals with mechanical neck pain that may be identifiable in clinical practice. METHODS: This report describes a secondary analysis of 5 independent, international mechanical neck pain databases of PPDT...... values taken at both a local and distal region (total N=1176). Minor systematic differences in mean PPDT values across cohorts necessitated z-transformation before analysis, and each cohort was split into male and female sexes. Latent profile analysis (LPA) using the k-means approach was undertaken...... to identify the most parsimonious set of PPDT-based phenotypes that were both statistically and clinically meaningful. RESULTS: LPA revealed 4 distinct clusters named according to PPDT levels at the local and distal zones: low-low PPDT (67%), mod-mod (25%), mod-high (4%), and high-high (4%). Secondary...

  3. Reaping the benefits of meaningful work: The mediating versus moderating role of work engagement.

    Science.gov (United States)

    Johnson, Matthew J; Jiang, Lixin

    2017-08-01

    This study examined whether meaningful work may improve one's quality of life outside of the workplace (i.e., work-to-life enrichment). More importantly, we proposed and tested competing hypotheses regarding the role of work engagement in the relationship between meaningful work and work-to-life enrichment. Specifically, we investigated whether work engagement served as a mediator of this relationship, as suggested by the job demands-resources model, or instead a moderator, as suggested by conservation of resources theory. Two-wave survey data were collected from 194 respondents recruited via Amazon Mechanical Turk. Analyses showed that meaningful work was positively related to work-to-life enrichment over time (i.e., 3 months later). Additionally, work engagement mediated but did not moderate the relationship between meaningful work at Time 1 and work-to-life enrichment at Time 2. We suggest that organizations foster a sense of meaningfulness in employees to facilitate engagement and in turn enrich employees' lives beyond the workplace. Therefore, not only organizations, but individuals as well may reap the benefits of meaningful work. Copyright © 2016 John Wiley & Sons, Ltd.

  4. Meaningful traits for grouping plant species across arid ecosystems.

    Science.gov (United States)

    Bär Lamas, Marlene Ivonne; Carrera, A L; Bertiller, M B

    2016-05-01

    Grouping species may provide some degree of simplification to understand the ecological function of plants on key ecosystem processes. We asked whether groups of plant species based on morpho-chemical traits associated with plant persistence and stress/disturbance resistance reflect dominant plant growth forms in arid ecosystems. We selected twelve sites across an aridity gradient in northern Patagonia. At each site, we identified modal size plants of each dominant species and assessed specific leaf area (SLA), plant height, seed mass, N and soluble phenol concentration in green and senesced leaves at each plant. Plant species were grouped according with plant growth forms (perennial grasses, evergreen shrubs and deciduous shrubs) and plant morphological and/or chemical traits using cluster analysis. We calculated mean values of each plant trait for each species group and plant growth form. Plant growth forms significantly differed among them in most of the morpho-chemical traits. Evergreen shrubs were tall plants with the highest seed mass and soluble phenols in leaves, deciduous shrubs were also tall plants with high SLA and the highest N in leaves, and perennial grasses were short plants with high SLA and low concentration of N and soluble phenols in leaves. Grouping species by the combination of morpho-chemical traits yielded 4 groups in which species from one growth form prevailed. These species groups differed in soluble phenol concentration in senesced leaves and plant height. These traits were highly correlated. We concluded that (1) plant height is a relevant synthetic variable, (2) growth forms adequately summarize ecological strategies of species in arid ecosystems, and (3) the inclusion of plant morphological and chemical traits related to defenses against environmental stresses and herbivory enhanced the potential of species grouping, particularly within shrubby growth forms.

  5. The categorisation of dysthymic disorder: can its constituents be meaningfully apportioned?

    Science.gov (United States)

    Rhebergen, Didi; Graham, Rebecca; Hadzi-Pavlovic, Dusan; Stek, Max; Friend, Paul; Barrett, Melissa; Parker, Gordon

    2012-12-20

    Since its introduction in DSM-III, the validity of dysthymia has been debated. Our objective is to further examine the concept of dysthymia in an outpatient sample, and explore whether its constituents can be meaningfully apportioned. 318 patients attending the Black Dog Institute Depression Clinic were assessed by the Mini-International Neuropsychiatric Interview, and completed several self-report measures, in addition to a clinical assessment by an Institute psychiatrist. The characteristics of patients with major depressive disorder (MDD), dysthymic disorder and double depression were examined. Latent Class Analysis (LCA) and Latent Profile Analysis (LPA) were then conducted with the aim of detecting distinct classes based on depressive symptomatology and personality domains, respectively. Finally, clinicians' formulations of the study patients were examined. Depression groups mainly differed on parameters of severity. Although LCA and LPA analyses indicated the presence of distinct classes, these only moderately correlated with the MINI-diagnosed groups. Finally, there was evidence for considerable heterogeneity within clinicians' formulations of dysthymia. Inadequate sample numbers for various measures limited the power of the LPA and our sample was weighted to patients with a more severe depressive condition which may affect the detection of a distinct 'dysthymic' personality profile. Despite employing a variety of techniques, we were unable to obtain a clear homogeneous picture of dysthymia. Rather, there was evidence for a distinct heterogeneity in clinician-derived diagnoses. These findings allude to the questionable discriminant validity of dysthymia and may encourage future research and discussion on this important topic. Copyright © 2012 Elsevier B.V. All rights reserved.

  6. Creating meaningful learning experiences: Understanding students' perspectives of engineering design

    Science.gov (United States)

    Aleong, Richard James Chung Mun

    There is a societal need for design education to prepare holistic engineers with the knowledge, skills, and attitudes to innovate and compete globally. Design skills are paramount to the espoused values of higher education, as institutions of higher learning strive to develop in students the cognitive abilities of critical thinking, problem solving, and creativity. To meet these interests from industry and academia, it is important to advance the teaching and learning of engineering design. This research aims to understand how engineering students learn and think about design, as a way for engineering educators to optimize instructional practice and curriculum development. Qualitative research methodology was used to investigate the meaning that engineering students' ascribe to engineering design. The recruitment of participants and corresponding collection of data occurred in two phases using two different data collection techniques. The first phase involved the distribution of a one-time online questionnaire to all first year, third year, and fourth year undergraduate engineering students at three Canadian Universities. After the questionnaire, students were asked if they would be willing to participate in the second phase of data collection consisting of a personal interview. A total of ten students participated in interviews. Qualitative data analysis procedures were conducted on students' responses from the questionnaire and interviews. The data analysis process consisted of two phases: a descriptive phase to code and categorize the data, followed by an interpretative phase to generate further meaning and relationships. The research findings present a conceptual understanding of students' descriptions about engineering design, structured within two educational orientations: a learning studies orientation and a curriculum studies orientation. The learning studies orientation captured three themes of students' understanding of engineering design: awareness

  7. Meaningful work and work engagement : The mediating role of perceived opportunity to craft and job crafting behavior

    NARCIS (Netherlands)

    Van Wingerden, Jessica; van der Stoep, Joost; Poell, R.F.

    2018-01-01

    This study examines the impact of meaningful work on employees’ level of work engagement as mediated by perceived opportunities to craft and job crafting. Based on the literature on meaningful work and job crafting, we hypothesize that meaningful work has a positive relationship with an employee’s

  8. Lattice parameter values and phase transitions for the Cu2Cd1-zMn zGeSe4 and Cu2Cd1-zFe zGeSe4 alloys

    International Nuclear Information System (INIS)

    Quintero, E.; Tovar, R.; Quintero, M.; Delgado, G.E.; Morocoima, M.; Caldera, D.; Ruiz, J.; Mora, A.E.; Briceno, M.; Fernandez, J.L.

    2007-01-01

    X-ray powder diffraction measurements and differential thermal analysis (DTA) were made on polycrystalline samples of the Cu 2 Cd 1-z Mn z GeSe 4 and Cu 2 Cd 1-z Fe z GeSe 4 alloy systems. The diffraction patterns were used to show the equilibrium conditions and to derive lattice parameter values. The effect of the annealing temperature and cooling rate to room temperature are discussed. For the Cu 2 Cd 1-z Fe z GeSe 4 system, only two single solid phase fields, the tetragonal stannite α and the wurtz-stannite δ structures were found to occur in the diagram. For the Cu 2 Cd 1-z Mn z GeSe 4 system, in addition to the tetragonal stannite α and the wurtz-stannite δ phases, MnSe was found to exist in the diagram. The DTA experiments showed that the cooling curves for both systems exhibited effects of undercooling

  9. Relationships between Flow Experience, Life Meaningfulness and Subjective Well-being in Music Students

    Directory of Open Access Journals (Sweden)

    Martin Sedlár

    2014-01-01

    Full Text Available The study examines relationships between flow experience in musical activities, life meaningfulness and subjective well – being. Life meaningfulness belongs to eudaimonic good life, subjective well–being belongs to hedonic good life and flow seems to be combination of both approaches. It is supposed that flow experience in musical activity and life meaningfulness should have positive impact on subjective well –being. The research sample consisted of 96 university music students (37 males, 59 females from the Music and Dance Faculty, Academy of Performing Arts in Bratislava, Slovakia. Dispositional Flow Scale–2, which measures nine dimension of flow, was used for measuring frequency o f flow experience. Life Meaningfulness Scale, which measures three dimensions of life meaningfulness, was used for measuring meaningfulness of life. Positive and Negative Affect Schedule measured affective components of subjective well–being, and Satisfaction with Life Scale measured cognitive component of subjective well–being. Categorization revealed that the most favourite performing musical activities are creative musical activities, such as reproduction and production, during which music students relatively often experience flow. The results of correlation analysis showed that total scores of flow experience, life meaningfulness and components of subjective well–being, significantly correlate each other. Aspects of flow, clear goals and autotelic experience are positively related to cognitive and motivational dimension of life meaningfulness and also to positive affectivity. Loss of self–consciousness and autotelic experience are positively related to emotional dimension of life meaningfulness. Challenge–skill balance, action–awareness merging, clear goals, concentration on task at hand, sense of control and autotelic experience are negatively related to negative affectivity. Challenge–skill balance and autotelic experience are related to

  10. Combining Radar and Daily Precipitation Data to Estimate Meaningful Sub-daily Precipitation Extremes

    Science.gov (United States)

    Pegram, G. G. S.; Bardossy, A.

    2016-12-01

    Short duration extreme rainfalls are important for design. The purpose of this presentation is not to improve the day by day estimation of precipitation, but to obtain reasonable statistics for the subdaily extremes at gauge locations. We are interested specifically in daily and sub-daily extreme values of precipitation at gauge locations. We do not employ the common procedure of using time series of control station to determine the missing data values in a target. We are interested in individual rare events, not sequences. The idea is to use radar to disaggregate daily totals to sub-daily amounts. In South Arica, an S-band radar operated relatively continuously at Bethlehem from 1998 to 2003, whose scan at 1.5 km above ground [CAPPI] overlapped a dense (10 km spacing) set of 45 pluviometers recording in the same 6-year period. Using this valuable set of data, we are only interested in rare extremes, therefore small to medium values of rainfall depth were neglected, leaving 12 days of ranked daily maxima in each set per year, whose sum typically comprised about 50% of each annual rainfall total. The method presented here uses radar for disaggregating daily gauge totals in subdaily intervals down to 15 minutes in order to extract the maxima of sub-hourly through to daily rainfall at each of 37 selected radar pixels [1 km square in plan] which contained one of the 45 pluviometers not masked out by the radar foot-print. The pluviometer data were aggregated to daily totals, to act as if they were daily read gauges; their only other task was to help in the cross-validation exercise. The extrema were obtained as quantiles by ordering the 12 daily maxima of each interval per year. The unusual and novel goal was not to obtain the reproduction of the precipitation matching in space and time, but to obtain frequency distributions of the gauge and radar extremes, by matching their ranks, which we found to be stable and meaningful in cross-validation tests. We provide and

  11. Novel Study Guides for Biochemistry Meaningful Learning in Biology: a Design-Based Research

    Directory of Open Access Journals (Sweden)

    Costa, C ; Galembeck, E. Costa, C ; Galembeck, E.

    2017-07-01

    Full Text Available One of the difficulties for biochemistry learning is the persistence of traditional teaching methods, based on transmission and memorization of abstract and detailed information, usually in a decontextualized way. Such scenario results in surface learning and content reproduction. In order to address these problems, three interventions in a discipline (Metabolism for Biology majors were applied, in the form of innovative teaching tools (study guides. OBJECTIVES: The main goal is to evaluate the impact of these interventions on interest, motivation, and learning of the metabolic pathways. MATERIALS AND METHODS: We describe the development, application, and evaluation of two study guides – one created from a problem used as a contextual connection for glycogen metabolism study and another embedding an integrative view based on glutamate metabolism. Both materials were guided by broad themes like evolution, metabolic adaptation, and comparative biochemistry. The development of the study guides combined submicroscopic (molecular and macroscopic (body, environment levels, aiming to motivate reading and discussion. A design-based research with cycles of application and assessment was carried out, by means of classroom observation, grade analysis in written exams, and students’ interviews. RESULTS AND DISCUSSION: In general, based on in-class student feedback to professors and to the researcher in the interviews, the study guides arouse curiosity and fostered peer discussion. Final average grades indicate a good global performance in all proposed activities. Whole data from study guides’ application in classroom evidenced their impact on interest, motivation, and learning. The strategy of developing problem or integrative situation linking molecular (micro and contextual (macro levels were helpful to foster critical thinking and to value topics of scientific literacy. CONCLUSIONS: Analysis and interpretation of the results point to benefits for

  12. Face Time: Meaningful Public Engagement Through Interactive, In-Person Outreach Efforts

    Science.gov (United States)

    Bartel, B. A.; Agopian, M.

    2017-12-01

    Science festivals, classrooms, community groups, and farmers markets provide rich opportunities for scientists to interact with the non-expert public. These venues offer scientists not only the opportunity to explain their science to the public, but to actually converse about the science, to put a human face with the scientific enterprise, and to learn about the values and knowledge levels of people within our communities. This interaction allows us to connect with a curious and sometimes skeptical public, correct misinformation, inspire the next generation (and the next generation's parents), and speak directly with voters about the relevance of science to our daily lives. While other channels of communication may reach a broader audience, these in-person, often one-on-one interactions make for meaningful, memorable, and potentially impactful experiences for scientists and non-experts alike. Skills used to engage the public in these planned events are the same skills we need to engage in any productive conversation. Communications training addressing effective conversations with non-experts can help scientists communicate more effectively not only by helping us hone our messaging, but also by recognizing our assumptions, biases, and our tendency to explain more than listen, even when our will is good. We have provided communications training based on the NSF-funded Portal to the Public (PoP) framework to students, post-docs, and educators. Feedback indicates these communications workshops improve participants' teaching abilities, confidence in engaging with the public, and even ability to articulate research to fellow scientists. In this presentation, we will share best practices for engaging non-experts based on PoP, as well as drawing from our experience in outreach at events, in classrooms, and in museums.

  13. Adverse pregnancy outcome in women with mild glucose intolerance: is there a clinically meaningful threshold value for glucose?

    DEFF Research Database (Denmark)

    Jensen, Dorte; Lauridsen, Lars Korsholm; Ovesen, Per Glud

    2008-01-01

    The diagnostic criteria of gestational diabetes mellitus (GDM) have been based on the risk of future maternal diabetes rather than the short-term risk of mother and infant. Our aim was to illustrate the relation between various adverse pregnancy outcomes and maternal glucose levels in women with ...

  14. Values in Qualitative and Quantitative Research

    Science.gov (United States)

    Duffy, Maureen; Chenail, Ronald J.

    2008-01-01

    The authors identify the philosophical underpinnings and value-ladenness of major research paradigms. They argue that useful and meaningful research findings for counseling can be generated from both qualitative and quantitative research methodologies, provided that the researcher has an appreciation of the importance of philosophical coherence in…

  15. Meaningful Clusters

    Energy Technology Data Exchange (ETDEWEB)

    Sanfilippo, Antonio P.; Calapristi, Augustin J.; Crow, Vernon L.; Hetzler, Elizabeth G.; Turner, Alan E.

    2004-05-26

    We present an approach to the disambiguation of cluster labels that capitalizes on the notion of semantic similarity to assign WordNet senses to cluster labels. The approach provides interesting insights on how document clustering can provide the basis for developing a novel approach to word sense disambiguation.

  16. Students’ Expectations and Experiences of Meaningful Simulation-Based Medical Education

    Directory of Open Access Journals (Sweden)

    Tuulikki Keskitalo

    2016-11-01

    Full Text Available This study aims to investigate students’ expectations and experiences of meaningful learning in simulation-based learning environments. We set the following research question: How do students’ experiences of meaningful simulation-based learning correspond to their expectations? The students’ (n = 87; male 51, female 36 pre- and post-questionnaires were analyzed using statistical methods. The results indicated that students’ expectations and experiences of meaningful learning were positive, and for most statements, there were statistically significant differences between the mean pre-questionnaire rating and the mean post-questionnaire rating, thereby indicating that students’ actual experiences of simulation-based learning were more positive than their expectations. Thus, students’ experiences exceeded their expectations.

  17. "Meaningful use" of electronic health records and its relevance to laboratories and pathologists

    Directory of Open Access Journals (Sweden)

    Walter H Henricks

    2011-01-01

    Full Text Available Electronic health records (EHRs have emerged as a major topic in health care and are central to the federal government′s strategy for transforming healthcare delivery in the United States. Recent federal actions that aim to promote the use of EHRs promise to have significant implications for laboratories and for pathology practices. Under the HITECH (Health Information Technology Economic and Clinical Health Act, an EHR incentive program has been established through which individual physicians and hospitals can qualify to receive incentive payments if they achieve "meaningful use" of "certified" EHR technology. The rule also establishes payment penalties in future years for eligible providers who have not met the requirements for meaningful use of EHRs. Meaningful use must be achieved using EHR technology that has been certified in accordance with functional and technical criteria that are set forth a regulation that parallels the meaningful use criteria in the incentive program. These actions and regulations are important to laboratories and pathologists for a number of reasons. Several of the criteria and requirements in the meaningful use rules and EHR certification criteria relate directly or indirectly to laboratory testing and laboratory information management, and future stage requirements are expected to impact the laboratory as well. Furthermore, as EHR uptake expands, there will be greater expectations for electronic interchange of laboratory information and laboratory information system (LIS-EHR interfaces. Laboratories will need to be aware of the technical, operational, and business challenges that they may face as expectations for LIS-EHR increase. This paper reviews the important recent federal efforts aimed at accelerating EHR use, including the incentive program for EHR meaningful use, provider eligibility, and EHR certification criteria, from a perspective of their relevance for laboratories and pathology practices.

  18. Health information technology: integration of clinical workflow into meaningful use of electronic health records.

    Science.gov (United States)

    Bowens, Felicia M; Frye, Patricia A; Jones, Warren A

    2010-10-01

    This article examines the role that clinical workflow plays in successful implementation and meaningful use of electronic health record (EHR) technology in ambulatory care. The benefits and barriers of implementing EHRs in ambulatory care settings are discussed. The researchers conclude that widespread adoption and meaningful use of EHR technology rely on the successful integration of health information technology (HIT) into clinical workflow. Without successful integration of HIT into clinical workflow, clinicians in today's ambulatory care settings will continue to resist adoption and implementation of EHR technology.

  19. The consistency and complementarity between critical meaningful learning theory and the epistemology of Paul Feyerabend

    Directory of Open Access Journals (Sweden)

    Felipe Damasio

    2015-12-01

    Full Text Available Researchers in science teaching have advocated concomitant education about and of science. To approach the nature and history of science in basic education is necessary to have an epistemological approach that can go between of rationalism of Bunge and relativism of Feyerabend. In this paper, it is argued that Feyerabend's epistemological stance is that more can help promote meaningful learning critical, so as to form inquiring, flexible, creative, innovative, tolerant and liberal people. In addition, the suggestions Feyerabend's epistemology also complement the Theory of Meaningful Learning Critical to propose a curriculum and a context for the principles of the theory are in science classrooms.

  20. Pilot Study of Flow and Meaningfulness as Psychological Learning Concepts in Patient Education: A Short Report

    DEFF Research Database (Denmark)

    Nicic, Sara; Nørby, Karina; Bruun Johansen, Clea

    2014-01-01

    of this study was to investigate the applicability of these concepts of positive psychological theory in a patient education setting. Methods: This pilot study combines participating observation of group based patient education and 8 qualitative interviews with 4 patients with type 2 diabetes. Meaning......Abstract Background: The aim of this pilot study was to explore patient experiences of meaningfulness and flow related to group based patient education in type 2 diabetes. Meaningfulness and flow are underexposed as psychological learning concepts in patient education, and the ambition...

  1. Creating a meaningful infection control program: one home healthcare agency's lessons.

    Science.gov (United States)

    Poff, Renee McCoy; Browning, Sarah Via

    2014-03-01

    Creating a meaningful infection control program in the home care setting proved to be challenging for agency leaders of one hospital-based home healthcare agency. Challenges arose when agency leaders provided infection control (IC) data to the hospital's IC Committee. The IC Section Chief asked for national benchmark comparisons to align home healthcare reporting to that of the hospital level. At that point, it was evident that the home healthcare IC program lacked definition and structure. The purpose of this article is to share how one agency built a meaningful IC program.

  2. WHATSAPP CONTRIBUTIONS IN SPANISH TEACHING: A PERSPECTIVE OF MEANINGFUL AND COLLABORATIVE LEARNING

    Directory of Open Access Journals (Sweden)

    Iandra Maria Weirich da Silva Coelho

    2017-08-01

    Full Text Available This article describes a didactic proposal, mediated by the use of WhatsApp as a potential tool for the teaching of Spanish as an additional language. Activities are drawn from collaborative and meaningful practice with authentic situations of the language usage, taking by reference the theoretical construct of the Theory of Meaningful Learning (AUSUBEL, 2003 and Collaborative Practice of Writing. The results identify positive contributions about the increased interest and motivation of students, promotion of discursive competence, interactivity, autonomy, about actions involving the authorship and collaborative construction in information network for knowledge sharing.

  3. Improving students' meaningful learning on the predictive nature of quantum mechanics

    Directory of Open Access Journals (Sweden)

    Rodolfo Alves de Carvalho Neto

    2009-03-01

    Full Text Available This paper deals with research about teaching quantum mechanics to 3rd year high school students and their meaningful learning of its predictive aspect; it is based on the Master’s dissertation of one of the authors (CARVALHO NETO, 2006. While teaching quantum mechanics, we emphasized its predictive and essentially probabilistic nature, based on Niels Bohr’s complementarity interpretation (BOHR, 1958. In this context, we have discussed the possibility of predicting measurement results in well-defined experimental contexts, even for individual events. Interviews with students reveal that they have used quantum mechanical ideas, suggesting their meaningful learning of the essentially probabilistic predictions of quantum mechanics.

  4. Value of Information Analysis Applied to the Economic Evaluation of Interventions Aimed at Reducing Juvenile Delinquency: An Illustration.

    Directory of Open Access Journals (Sweden)

    Hester V Eeren

    Full Text Available To investigate whether a value of information analysis, commonly applied in health care evaluations, is feasible and meaningful in the field of crime prevention.Interventions aimed at reducing juvenile delinquency are increasingly being evaluated according to their cost-effectiveness. Results of cost-effectiveness models are subject to uncertainty in their cost and effect estimates. Further research can reduce that parameter uncertainty. The value of such further research can be estimated using a value of information analysis, as illustrated in the current study. We built upon an earlier published cost-effectiveness model that demonstrated the comparison of two interventions aimed at reducing juvenile delinquency. Outcomes were presented as costs per criminal activity free year.At a societal willingness-to-pay of €71,700 per criminal activity free year, further research to eliminate parameter uncertainty was valued at €176 million. Therefore, in this illustrative analysis, the value of information analysis determined that society should be willing to spend a maximum of €176 million in reducing decision uncertainty in the cost-effectiveness of the two interventions. Moreover, the results suggest that reducing uncertainty in some specific model parameters might be more valuable than in others.Using a value of information framework to assess the value of conducting further research in the field of crime prevention proved to be feasible. The results were meaningful and can be interpreted according to health care evaluation studies. This analysis can be helpful in justifying additional research funds to further inform the reimbursement decision in regard to interventions for juvenile delinquents.

  5. Public Values

    DEFF Research Database (Denmark)

    Beck Jørgensen, Torben; Rutgers, Mark R.

    2015-01-01

    administration is approached in terms of processes guided or restricted by public values and as public value creating: public management and public policy-making are both concerned with establishing, following and realizing public values. To study public values a broad perspective is needed. The article suggest......This article provides the introduction to a symposium on contemporary public values research. It is argued that the contribution to this symposium represent a Public Values Perspective, distinct from other specific lines of research that also use public value as a core concept. Public...... a research agenda for this encompasing kind of public values research. Finally the contributions to the symposium are introduced....

  6. Parent Perceptions of Time Spent Meaningfully by Young Adults with Pervasive Support Needs

    Science.gov (United States)

    Rossetti, Zachary; Lehr, Donna; Lederer, Leslie; Pelerin, Dana; Huang, Shuoxi

    2015-01-01

    This article describes a qualitative study that examined how 23 young adults with pervasive support needs and limited functional communication spent their time and how their parents (n = 23) and direct support professionals (DSPs; n = 2) defined meaningfulness in relation to the young adults' experiences. Data were collected through…

  7. Measuring Meaningful Learning in the Undergraduate Chemistry Laboratory: A National, Cross-Sectional Study

    Science.gov (United States)

    Galloway, Kelli R.; Bretz, Stacey Lowery

    2015-01-01

    Research on laboratory learning points to the need to better understand what and how students learn in the undergraduate chemistry laboratory. The Meaningful Learning in the Laboratory Instrument (MLLI) was administered to general and organic chemistry students from 15 colleges and universities across the United States in order to measure the…

  8. Pedagogical Background for Technology Education--Meaningful Learning in Theory and Practice

    Science.gov (United States)

    Autio, Ossi

    2009-01-01

    One important theme in technology education is the growing need to develop the type of pedagogies that encourage pupils in authentic and meaningful learning experiences. Often, the teaching strategies of technology education are only a matter of teaching the handling of materials and tools, and the production of mere objects does not consider how…

  9. Using Cluster Analysis to Characterize Meaningful Learning in a First-Year University Chemistry Laboratory Course

    Science.gov (United States)

    Galloway, Kelli R.; Bretz, Stacey Lowery

    2015-01-01

    The Meaningful Learning in the Laboratory Instrument (MLLI) was designed to measure students' cognitive and affective learning in the university chemistry laboratory. The MLLI was administered at the beginning and the end of the first semester to first-year university chemistry students to measure their expectations and experiences for learning in…

  10. Meaningful Gamification and Students' Motivation: A Strategy for Scaffolding Reading Material

    Science.gov (United States)

    Ling, Lynette Tan Yuen

    2018-01-01

    Gamification is an innovative pedagogical strategy where digital games are used in an educational setting and as an aid to learning. Recent publications on gamification in the classroom investigate the concept of "meaningful gamification," where, in line with Ryan and Deci's self-determination theory, competency, autonomy, and…

  11. Meaningful Understanding and Systems Thinking in Organic Chemistry: Validating Measurement and Exploring Relationships

    Science.gov (United States)

    Vachliotis, Theodoros; Salta, Katerina; Tzougraki, Chryssa

    2014-01-01

    The purpose of this study was dual: First, to develop and validate assessment schemes for assessing 11th grade students' meaningful understanding of organic chemistry concepts, as well as their systems thinking skills in the domain. Second, to explore the relationship between the two constructs of interest based on students' performance…

  12. Patient-perceived satisfactory improvement (PPSI): interpreting meaningful change in pain from the patient's perspective

    NARCIS (Netherlands)

    ten Klooster, Peter M.; Drossaers-Bakker, K.W.; Taal, Erik; van de Laar, Mart A F J

    2006-01-01

    The assessment of clinically meaningful changes in patient-reported pain has become increasingly important when interpreting results of clinical studies. However, proposed response criteria, such as the minimal clinically important difference, do not correspond with the growing need for information

  13. 75 FR 28331 - Meaningful Access to United States Currency for Blind and Visually Impaired Persons

    Science.gov (United States)

    2010-05-20

    ... feature is used in some foreign currency, and the Study's data indicated that this feature was more... Currency for Blind and Visually Impaired Persons AGENCY: Bureau of Engraving and Printing, Department of... meaningful access to U.S. currency to people who are blind and visually impaired pursuant to section 504 of...

  14. Callings, Work Role Fit, Psychological Meaningfulness and Work Engagement among Teachers in Zambia

    Science.gov (United States)

    Rothmann, Sebastiaan; Hamukang'andu, Lukondo

    2013-01-01

    Our aim in this study was to investigate the relationships among a calling orientation, work role fit, psychological meaningfulness and work engagement of teachers in Zambia. A quantitative approach was followed and a cross-sectional survey was used. The sample (n = 150) included 75 basic and 75 secondary school teachers in the Choma district of…

  15. Doing the Project and Learning the Content: Designing Project-Based Science Curricula for Meaningful Understanding

    Science.gov (United States)

    Kanter, David E.

    2010-01-01

    Project-based science curricula can improve students' usable or meaningful understanding of the science content underlying a project. However, such curricula designed around "performances" wherein students design or make something do not always do this. We researched ways to design performance project-based science curricula (pPBSc) to better…

  16. Towards a More Meaningful Involvement of Librarians in Academic Program Reviews

    Science.gov (United States)

    Bowker, Lynne

    2018-01-01

    Purpose: Using a descriptive case study approach, this paper aims to validate academic librarians' perceptions that they are marginalized by faculty during academic program reviews, and recommends ways for the two groups to collaborate more effectively to make program reviews more meaningful. Design/methodology/approach: The paper describes a case…

  17. "Seeing the Whole Elephant": Changing Mindsets and Empowering Stakeholders to Meaningfully Manage Accountability and Improvement

    Science.gov (United States)

    Bush-Mecenas, Susan; Marsh, Julie A.; Montes de Oca, David; Hough, Heather

    2018-01-01

    School accountability and improvement policy are on the precipice of a paradigm shift. While the multiple-measure dashboard accountability approach holds great promise for promoting more meaningful learning opportunities for all students, our research indicates that this can come with substantial challenges in practice. We reflect upon the lessons…

  18. Beyond Needs Analysis: Soft Systems Methodology for Meaningful Collaboration in EAP Course Design

    Science.gov (United States)

    Tajino, Akira; James, Robert; Kijima, Kyoichi

    2005-01-01

    Designing an EAP course requires collaboration among various concerned stakeholders, including students, subject teachers, institutional administrators and EAP teachers themselves. While needs analysis is often considered fundamental to EAP, alternative research methodologies may be required to facilitate meaningful collaboration between these…

  19. Meaningfulness for creation of growth in Small- and Medium-sized enterprises

    DEFF Research Database (Denmark)

    Brink, Tove; Neville, Mette

    2016-01-01

    The research in this paper reveals how meaningfulness of growth can be created in Small- and Medium-sized Enterprises (SMEs). The research is conducted in a four-year period with 24 SMEs participating from different industry branches. The research is now in the late part of the 3rd. year starting...

  20. Community-based medical education: is success a result of meaningful personal learning experiences?

    Science.gov (United States)

    Kelly, Len; Walters, Lucie; Rosenthal, David

    2014-01-01

    Community-based medical education (CBME) is the delivery of medical education in a specific social context. Learners become a part of social and medical communities where their learning occurs. Longitudinal integrated clerkships (LICs) are year-long community-based placements where the curriculum and clinical experience is typically delivered by primary care physicians. These programs have proven to be robust learning environments, where learners develop strong communication skills and excellent clinical reasoning. To date, no learning model has been offered to describe CBME. The characteristics of CBME are explored by the authors who suggest that the social and professional context provided in small communities enhances medical education. The authors postulate that meaningfulness is engendered by the authentic context, which develops over time. These relationships with preceptors, patients and the community provide meaningfulness, which in turn enhances learning. The authors develop a novel learning model. They propose that the context-rich environment of CBME allows for meaningful relationships and experiences for students and that such meaningfulness enhances learning.

  1. Meaningful Learning in the Teaching of Culture: The Project Based Learning Approach

    Science.gov (United States)

    Kean, Ang Chooi; Kwe, Ngu Moi

    2014-01-01

    This paper reports on a collaborative effort taken by a team of three teacher educators in using the Project Based Learning (PBL) approach in the teaching of Japanese culture with the aim to investigate the presence of actual "meaningful learning" among 15 students of a 12-Week Preparatory Japanese Language course under a teacher…

  2. Magnitude and meaningfulness of change in SF-36 scores in four types of orthopedic surgery

    DEFF Research Database (Denmark)

    Busija, Lucy; Osborne, Richard H; Nilsdotter, Anna

    2008-01-01

    BACKGROUND: The Medical Outcomes General Health Survey (SF-36) is a widely used health status measure; however, limited evidence is available for its performance in orthopedic settings. The aim of this study was to examine the magnitude and meaningfulness of change and sensitivity of SF-36...

  3. Finding pathways to more equitable and meaningful public-scientist partnerships

    Science.gov (United States)

    Daniela Soleri; Jonathan W. Long; Monica D. Ramirez-Andreotta; Ruth Eitemiller; Rajul Pandyaǁ

    2016-01-01

    For many, citizen science is exciting because of the possibility for more diverse, equitable partnerships in scientific research with outcomes considered meaningful and useful by all, including public participants. This was the focus of a symposium we organized at the 2015 conference of the Citizen Science Association. Here we synthesize points made by symposium...

  4. The categorisation of dysthymic disorder: Can its constituents be meaningfully apportioned?

    NARCIS (Netherlands)

    Rhebergen, D.; Graham, R.; Hadzi-Pavlovic, D.; Stek, M.L.; Friend, P.; Barrett, M.; Parker, G.

    2012-01-01

    Background: Since its introduction in DSM-III, the validity of dysthymia has been debated. Our objective is to further examine the concept of dysthymia in an outpatient sample, and explore whether its constituents can be meaningfully apportioned. Methods: 318 patients attending the Black Dog

  5. Mutually Beneficial Foreign Language Learning: Creating Meaningful Interactions through Video-Synchronous Computer-Mediated Communication

    Science.gov (United States)

    Kato, Fumie; Spring, Ryan; Mori, Chikako

    2016-01-01

    Providing learners of a foreign language with meaningful opportunities for interactions, specifically with native speakers, is especially challenging for instructors. One way to overcome this obstacle is through video-synchronous computer-mediated communication tools such as Skype software. This study reports quantitative and qualitative data from…

  6. Meaningful Share Generation for Increased Number of Secrets in Visual Secret-Sharing Scheme

    Directory of Open Access Journals (Sweden)

    Mustafa Ulutas

    2010-01-01

    Full Text Available This paper presents a new scheme for hiding two halftone secret images into two meaningful shares created from halftone cover images. Meaningful shares are more desirable than noise-like (meaningless shares in Visual Secret Sharing because they look natural and do not attract eavesdroppers' attention. Previous works in the field focus on either increasing number of secrets or creating meaningful shares for one secret image. The method outlined in this paper both increases the number of secrets and creates meaningful shares at the same time. While the contrast ratio of shares is equal to that of Extended Visual Cryptography, two secrets are encoded into two shares as opposed to one secret in the Extended Visual Cryptography. Any two natural-looking images can be used as cover unlike the Halftone Visual Cryptography method where one cover should be the negative of the other cover image and can only encode one secret. Effectiveness of the proposed method is verified by an experiment.

  7. Mediating role of meaningful work between resources and work engagement in Bangladesh’s private banks

    Directory of Open Access Journals (Sweden)

    Nawrin Rubaba

    2018-03-01

    Full Text Available Engaged employees are considered as the most desired assets for the organization. Although significant contributions have been observed in the engagement literature, a holistic approach is yet to be untouched in terms of developing relationship between various resources, work engagement and psychological mechanism such as meaningful work. The purpose of this study is to explore the mediating role of meaningful work between resources and work engagement in private banks in Bangladesh. This study followed the quantitative methodological approach and based on Bakker and Demerouti’s (2007 Job demand-resources model. A survey questionnaire was prepared and used to collect data. 440 respondents participated in this study, who is currently working in private banks in Bangladesh. Multiple regression analysis along with Sobel test was performed to analyze the data. The findings confirmed that the relationships between organizational, job, personal resources and work engagement were partially mediated through meaningful work. It has been observed that all determinates had a significant influence on work engagement. For practical implications, the organization can align various resources to uplift the engagement level of the employees. Since meaningful work was found to be a significant predictor, managers can develop jobs where employees can relate their purpose to their work. This study recommends that future research can apply this model to different contexts as well as to different groups of respondents.

  8. Transforming City Schools through Art: Approaches to Meaningful K-12 Learning

    Science.gov (United States)

    Hutzel, Karen; Bastos, Flavia M. C.; Cozier, Kimberly J.

    2012-01-01

    This anthology places art at the center of meaningful urban education reform. Providing a fresh perspective on urban education, the contributors describe a positive, asset-based community development model designed to tap into the teaching/learning potential already available in urban cities. Rather than focusing on a lack of resources, this…

  9. The association of meaningfulness, well-being, and engagement with absenteeism : A moderated mediation model

    NARCIS (Netherlands)

    Soane, E.; Shantz, A.; Alfes, K.; Truss, C.; Rees, C.; Gatenby, M.

    2013-01-01

    We theorized that absence from work is a resource-based process that is related to perceived meaningfulness of work, well-being, and engagement. Broaden-and-build theory (Fredrickson, 1998, 2001) and engagement theory (Bakker, Schaufeli, Leiter, & Taris, 2008; Kahn, 1990) were used to develop a

  10. The Right to Appropriate and Meaningful Education for Children with ASD

    Science.gov (United States)

    Marshall, David; Goodall, Craig

    2015-01-01

    This paper will explore from a "child's rights perspective" the "right" of children with autistic spectrum disorder (ASD) to appropriate and meaningful education. Human "rights" principles within international law will be evaluated in relation to how they have been interpreted and applied in relation to achieving this…

  11. The Omaha system and meaningful use: applications for practice, education, and research.

    Science.gov (United States)

    Martin, Karen S; Monsen, Karen A; Bowles, Kathryn H

    2011-01-01

    Meaningful use has become ubiquitous in the vocabulary of health information technology. It suggests that better healthcare does not result from the adoption of technology and electronic health records, but by increasing interoperability and informing clinical decisions at the point of care. Although the initial application of meaningful use was limited to eligible professionals and hospitals, it incorporates complex processes and workflow that involve all nurses, other healthcare practitioners, and settings. The healthcare community will become more integrated, and interdisciplinary practitioners will provide enhanced patient-centered care if electronic health records adopt the priorities of meaningful use. Standardized terminologies are a necessary component of such electronic health records. The Omaha System is an exemplar of a standardized terminology that enables meaningful use of clinical data to support and improve patient-centered clinical practice, education, and research. It is user-friendly, generates data that can be shared with patients and their families, and enables healthcare providers to analyze and exchange patient-centered coded data. Use of the Omaha System is increasing steadily in diverse practice, education, and research settings nationally and internationally.

  12. Measuring Meaningful Learning in the Undergraduate General Chemistry and Organic Chemistry Laboratories: A Longitudinal Study

    Science.gov (United States)

    Galloway, Kelli R.; Bretz, Stacey Lowery

    2015-01-01

    Understanding how students learn in the undergraduate chemistry teaching laboratory is an essential component to developing evidence-based laboratory curricula. The Meaningful Learning in the Laboratory Instrument (MLLI) was developed to measure students' cognitive and affective expectations and experiences for learning in the chemistry…

  13. The Effect of Case Teaching on Meaningful and Retentive Learning When Studying Genetic Engineering

    Science.gov (United States)

    Güccük, Ahmet; Köksal, Mustafa Serdar

    2017-01-01

    The purpose of this study is to investigate the effects of case teaching on how students learn about genetic engineering, in terms of meaningful learning and retention of learning. The study was designed as quasi-experimental research including 63 8th graders (28 boys and 35 girls). To collect data, genetic engineering achievement tests were…

  14. Does (Non-)Meaningful Sensori-Motor Engagement Promote Learning With Animated Physical Systems?

    NARCIS (Netherlands)

    Pouw, Wim T J L; Eielts, Charly; van Gog, Tamara; Zwaan, Rolf A.; Paas, Fred

    2016-01-01

    Previous research indicates that sensori-motor experience with physical systems can have a positive effect on learning. However, it is not clear whether this effect is caused by mere bodily engagement or the intrinsically meaningful information that such interaction affords in performing the

  15. Integrating Concept Mapping into Information Systems Education for Meaningful Learning and Assessment

    Science.gov (United States)

    Wei, Wei; Yue, Kwok-Bun

    2017-01-01

    Concept map (CM) is a theoretically sound yet easy to learn tool and can be effectively used to represent knowledge. Even though many disciplines have adopted CM as a teaching and learning tool to improve learning effectiveness, its application in IS curriculum is sparse. Meaningful learning happens when one iteratively integrates new concepts and…

  16. Using Mobile Tools to Support Meaningful Work-based Learning in Vocational Education

    Directory of Open Access Journals (Sweden)

    Hanna Vuojärvi

    2016-11-01

    Full Text Available This case study focused on meaningful work-based learning (WBL and the pedagogical use of mobile information and communication technologies (ICTs in vocational tourism education. The aim was to reveal how teaching/tutoring and learning are realized and how the use of smartphones supports the realization of meaningful learning characteristics during WBL periods in highly versatile environments. Within a design-based research framework, the data was collected through learning journals written by students and qualitative interviews. The results of thematic analysis were used to develop a practice-oriented pedagogical model for meaningful WBL. The model visualizes the roles of students, teachers, and companies involved in WBL, the meaningful learning characteristics that can be amplified through the use of mobile ICTs, and the outcomes for each stakeholder. The model suggests structuring WBL through four negotiations involving a student, a teacher, and a company to assure that each student has clearly formulated learning goals and possibilities to pursue those goals regardless of the mobility of their work or facilities during their WBL period.

  17. Which role for Life Cycle Thinking in the definition of meaningful indicators for the circular economy?

    DEFF Research Database (Denmark)

    Niero, Monia

    2017-01-01

    at the micro level. We discuss the role of Life Cycle Thinking (LCT) in the development of meaningful circularity indicators at the product level taking into account the absolute perspective on CE. Our analysis is limited to the environmental aspect of sustainability with a focus on the climate change impact...

  18. Representing and Practising Meaningful Differences in a Well-Structured but Complex Art Curriculum

    Science.gov (United States)

    Cunliffe, Leslie

    2010-01-01

    This paper conceptualizes the secondary art curriculum as a well-structured but complex knowledge-domain, with the aim of emphasizing meaningful differences in the way creative grammar operates in the following gatherings of art practices: Pre-historic and non-European cultures; Ancient and European cultures before c. 1800; Romantic and Modern…

  19. Application of Ausubel's Theory of Meaningful Verbal Learning to Curriculum, Teaching and Learning of Deaf Students.

    Science.gov (United States)

    Biser, Eileen

    Implications of D. Ausubel's Theory of Meaningful Verbal Learning and its derivative, the Advance Organizer Model of Teaching, for deaf students are examined. Ausubel believes that complex intellectual processes (thinking, language, problem-solving, concept formation) are the major aspects of learning, and that primary emphasis should be placed on…

  20. Meaningful cultural learning by imitative participation: the case of abstract thinking in primary school

    NARCIS (Netherlands)

    van Oers, B.

    2012-01-01

    The article describes a theory-driven approach to meaningful learning in primary schools, based on the Vygotskian cultural-historical theory of human development and learning. This approach is elaborated into an educational concept called 'developmental education' that is implemented in the

  1. Security, Dignity, Caring Relationships, and Meaningful Work: Needs Motivating Participation in a Job-Training Program

    Science.gov (United States)

    Ayers, David F.; Miller-Dyce, Cherrel; Carlone, David

    2008-01-01

    Researchers asked 17 participants in a job-training program to describe their personal struggles following an economic restructuring. Examined through a critical theoretical lens, findings indicate that the learners enrolled in the program to reclaim security, dignity, meaningful work, and caring relationships. Program planners at community…

  2. Bomb parameters

    International Nuclear Information System (INIS)

    Kerr, George D.; Young, Rebert W.; Cullings, Harry M.; Christry, Robert F.

    2005-01-01

    The reconstruction of neutron and gamma-ray doses at Hiroshima and Nagasaki begins with a determination of the parameters describing the explosion. The calculations of the air transported radiation fields and survivor doses from the Hiroshima and Nagasaki bombs require knowledge of a variety of parameters related to the explosions. These various parameters include the heading of the bomber when the bomb was released, the epicenters of the explosions, the bomb yields, and the tilt of the bombs at time of explosion. The epicenter of a bomb is the explosion point in air that is specified in terms of a burst height and a hypocenter (or the point on the ground directly below the epicenter of the explosion). The current reassessment refines the energy yield and burst height for the Hiroshima bomb, as well as the locations of the Hiroshima and Nagasaki hypocenters on the modern city maps used in the analysis of the activation data for neutrons and TLD data for gamma rays. (J.P.N.)

  3. Annotating spatio-temporal datasets for meaningful analysis in the Web

    Science.gov (United States)

    Stasch, Christoph; Pebesma, Edzer; Scheider, Simon

    2014-05-01

    More and more environmental datasets that vary in space and time are available in the Web. This comes along with an advantage of using the data for other purposes than originally foreseen, but also with the danger that users may apply inappropriate analysis procedures due to lack of important assumptions made during the data collection process. In order to guide towards a meaningful (statistical) analysis of spatio-temporal datasets available in the Web, we have developed a Higher-Order-Logic formalism that captures some relevant assumptions in our previous work [1]. It allows to proof on meaningful spatial prediction and aggregation in a semi-automated fashion. In this poster presentation, we will present a concept for annotating spatio-temporal datasets available in the Web with concepts defined in our formalism. Therefore, we have defined a subset of the formalism as a Web Ontology Language (OWL) pattern. It allows capturing the distinction between the different spatio-temporal variable types, i.e. point patterns, fields, lattices and trajectories, that in turn determine whether a particular dataset can be interpolated or aggregated in a meaningful way using a certain procedure. The actual annotations that link spatio-temporal datasets with the concepts in the ontology pattern are provided as Linked Data. In order to allow data producers to add the annotations to their datasets, we have implemented a Web portal that uses a triple store at the backend to store the annotations and to make them available in the Linked Data cloud. Furthermore, we have implemented functions in the statistical environment R to retrieve the RDF annotations and, based on these annotations, to support a stronger typing of spatio-temporal datatypes guiding towards a meaningful analysis in R. [1] Stasch, C., Scheider, S., Pebesma, E., Kuhn, W. (2014): "Meaningful spatial prediction and aggregation", Environmental Modelling & Software, 51, 149-165.

  4. Enhancing the Meaningfulness of Work for Astronauts on Long Duration Space Exploration Missions.

    Science.gov (United States)

    Britt, Thomas W; Sytine, Anton; Brady, Ashley; Wilkes, Russ; Pittman, Rebecca; Jennings, Kristen; Goguen, Kandice

    2017-08-01

    Numerous authors have identified the stressors likely to be encountered on long duration space exploration missions (e.g., to Mars), including the possibility of significant crises, separation from family, boredom/monotony, and interpersonal conflict. Although many authors have noted that meaningful work may be beneficial for astronauts on these missions, none have detailed the sources of meaningful work for astronauts and how these sources may differ between astronauts. The present article identifies how engagement in meaningful work during long duration missions may mitigate the adverse effects of demands and increase the potential for benefits resulting from the missions. Semistructured interviews were conducted with nine NASA personnel, including astronauts, flight directors, and flight surgeons. Questions addressed sources of meaning for astronauts, characteristics of tasks that enhance vs. detract from meaning, and recommendations for enhancing meaning. Personnel mentioned contributing to humanity and the next generation, contributing to the mission, and exploration as the most meaningful aspects of their work. Characteristics of tasks that enhanced meaning included using a variety of skills, feeling personal control over their schedule, autonomy in the execution of tasks, and understanding the importance of the experiments conducted on the mission. Top recommendations to sustain meaning were insuring social needs were met through such activities as the strategic use of social media, giving astronauts autonomy as well as structure, and conducting training during transit. Implications are addressed for tailoring meaning-based interventions for astronauts participating on long duration missions and assessing the effectiveness of these interventions.Britt TW, Sytine A, Brady A, Wilkes R, Pittman R, Jennings K, Goguen K. Enhancing the meaningfulness of work for astronauts on long duration space exploration missions. Aerosp Med Hum Perform. 2017; 88(8):779-783.

  5. Hospital IT adoption strategies associated with implementation success: implications for achieving meaningful use.

    Science.gov (United States)

    Ford, Eric W; Menachemi, Nir; Huerta, Timothy R; Yu, Feliciano

    2010-01-01

    Health systems are facing significant pressure to either implement health information technology (HIT) systems that have "certified" electronic health record applications and that fulfill the federal government's definition of "meaningful use" or risk substantial financial penalties in the near future. To this end, hospitals have adopted one of three strategies, described as "best of breed," "best of suite," and "single vendor," to meet organizational and regulatory demands. The single-vendor strategy is used by the simple majority of U.S. hospitals, but is it the most effective mode for achieving full implementation? Moreover, what are the implications of adopting this strategy for achieving meaningful use? The simple answer to the first question is that the hospitals using the hybrid best of suite strategy had fully implemented HIT systems in significantly greater proportions than did hospitals employing either of the other strategies. Nonprofit and system-affiliated hospitals were more likely to have fully implemented their HIT systems. In addition, increased health maintenance organization market penetration rates were positively correlated with complete implementation rates. These results have ongoing implications for achieving meaningful use in the near term. The federal government's rewards and incentives program related to the meaningful use of HIT in hospitals has created an organizational imperative to implement such systems. For hospitals that have not begun systemwide implementation, pursuing a best of suite strategy may provide the greatest chance for achieving all or some of the meaningful use targets in the near term or at least avoiding future penalties scheduled to begin in 2015.

  6. Meaningful Words and Non-Words Repetitive Articulatory Rate (Oral Diadochokinesis) in Persian Speaking Children.

    Science.gov (United States)

    Zamani, Peyman; Rezai, Hossein; Garmatani, Neda Tahmasebi

    2017-08-01

    Repetitive articulatory rate or Oral Diadochokinesis (oral-DDK) shows a guideline for appraisal and diagnosis of subjects with oral-motor disorder. Traditionally, meaningless words repetition has been utilized in this task and preschool children have challenges with them. Therefore, we aimed to determine some meaningful words in order to test oral-DDK in Persian speaking preschool children. Participants were 142 normally developing children, (age range 4-6 years), who were asked to produce /motæka, golabi/ as two meaningful Persian words and /pa-ta-ka/ as non-word in conventional oral-DDK task. We compared the time taken for 10-times fast repetitions of two meaningful Persian words and the tri-syllabic nonsense word /pa-ta-ka/. Praat software was used to calculate the average time that subjects took to produce the target items. In 4-5 year old children, [Formula: see text] of time taken for 10-times repetitions of /pa-ta-ka, motæka, golabi/ were [Formula: see text], and [Formula: see text] seconds respectively, and in 5-6 year old children were [Formula: see text], and [Formula: see text] seconds respectively. Findings showed that the main effect of type of words on oral diadochokinesis was significant ([Formula: see text]). Children repeated meaningful words /motæka, golabi/ faster than the non-word /pa-ta-ka/. Sex and age factors had no effect on time taken for repetition of oral-DDK test. It is suggested that Speech Therapists can use meaningful words to facilitate oral-DDK test for children.

  7. Science modelling in pre-calculus: how to make mathematics problems contextually meaningful

    Science.gov (United States)

    Sokolowski, Andrzej; Yalvac, Bugrahan; Loving, Cathleen

    2011-04-01

    'Use of mathematical representations to model and interpret physical phenomena and solve problems is one of the major teaching objectives in high school math curriculum' (National Council of Teachers of Mathematics (NCTM), Principles and Standards for School Mathematics, NCTM, Reston, VA, 2000). Commonly used pre-calculus textbooks provide a wide range of application problems. However, these problems focus students' attention on evaluating or solving pre-arranged formulas for given values. The role of scientific content is reduced to provide a background for these problems instead of being sources of data gathering for inducing mathematical tools. Students are neither required to construct mathematical models based on the contexts nor are they asked to validate or discuss the limitations of applied formulas. Using these contexts, the instructor may think that he/she is teaching problem solving, where in reality he/she is teaching algorithms of the mathematical operations (G. Kulm (ed.), New directions for mathematics assessment, in Assessing Higher Order Thinking in Mathematics, Erlbaum, Hillsdale, NJ, 1994, pp. 221-240). Without a thorough representation of the physical phenomena and the mathematical modelling processes undertaken, problem solving unintentionally appears as simple algorithmic operations. In this article, we deconstruct the representations of mathematics problems from selected pre-calculus textbooks and explicate their limitations. We argue that the structure and content of those problems limits students' coherent understanding of mathematical modelling, and this could result in weak student problem-solving skills. Simultaneously, we explore the ways to enhance representations of those mathematical problems, which we have characterized as lacking a meaningful physical context and limiting coherent student understanding. In light of our discussion, we recommend an alternative to strengthen the process of teaching mathematical modelling - utilization

  8. Towards a More Biologically-meaningful Climate Characterization: Variability in Space and Time at Multiple Scales

    Science.gov (United States)

    Christianson, D. S.; Kaufman, C. G.; Kueppers, L. M.; Harte, J.

    2013-12-01

    Sampling limitations and current modeling capacity justify the common use of mean temperature values in summaries of historical climate and future projections. However, a monthly mean temperature representing a 1-km2 area on the landscape is often unable to capture the climate complexity driving organismal and ecological processes. Estimates of variability in addition to mean values are more biologically meaningful and have been shown to improve projections of range shifts for certain species. Historical analyses of variance and extreme events at coarse spatial scales, as well as coarse-scale projections, show increasing temporal variability in temperature with warmer means. Few studies have considered how spatial variance changes with warming, and analysis for both temporal and spatial variability across scales is lacking. It is unclear how the spatial variability of fine-scale conditions relevant to plant and animal individuals may change given warmer coarse-scale mean values. A change in spatial variability will affect the availability of suitable habitat on the landscape and thus, will influence future species ranges. By characterizing variability across both temporal and spatial scales, we can account for potential bias in species range projections that use coarse climate data and enable improvements to current models. In this study, we use temperature data at multiple spatial and temporal scales to characterize spatial and temporal variability under a warmer climate, i.e., increased mean temperatures. Observational data from the Sierra Nevada (California, USA), experimental climate manipulation data from the eastern and western slopes of the Rocky Mountains (Colorado, USA), projected CMIP5 data for California (USA) and observed PRISM data (USA) allow us to compare characteristics of a mean-variance relationship across spatial scales ranging from sub-meter2 to 10,000 km2 and across temporal scales ranging from hours to decades. Preliminary spatial analysis at

  9. Mathematical modeling of CA125 kinetics in recurrent ovarian cancer (ROC) patients treated with chemotherapy and predictive value of early modeled kinetic parameters in CALYPSO trial: A GCIG study

    DEFF Research Database (Denmark)

    You, Benoit; Colomban, Olivier; Heywood, Mark

    2011-01-01

    Background: Although CA125 kinetic profiles may be related with relapse risk in ovarian cancer patients treated with chemotherapy, no reliable kinetic parameters have been reported. Mathematical modeling may help describe CA125 decline dynamically and determine parameters predictive of relapse....... Methods: Data from CALYPSO phase III trial data comparing 2 carboplatin-based regimens in ROC patients were analyzed. Based on population kinetic approach (Monolix software), a semi-mechanistic model was used to fit serum log (CA125) concentration-time profiles with following parameters: tumor growth rate...... the first 50 treatment days were tested regarding progression free survival (PFS) against other reported prognostic factors using Cox-models: treatment arm; platinum-free interval (PFI), metastatic site number, largest tumor size, elevated WBC and measurable disease. Results: The CA125 kinetics from 898...

  10. Values Research

    Science.gov (United States)

    2009-10-01

    that individualistic employees in individualistic organizations and collectivistic employees in collectivistic organizations show greater job...with Parsons’ causal assumption, in the nineties values were recognized on top of the cultural control –values control norms which in turn control...determines intention which may end in behavior. 7 Defining Human Values Cross- cultural theories on values emerged in the 80s developed by three main

  11. Estimation of mean and median pO2 values for a composite EPR spectrum.

    Science.gov (United States)

    Ahmad, Rizwan; Vikram, Deepti S; Potter, Lee C; Kuppusamy, Periannan

    2008-06-01

    Electron paramagnetic resonance (EPR)-based oximetry is capable of quantifying oxygen content in samples. However, for a heterogeneous environment with multiple pO2 values, peak-to-peak linewidth of the composite EPR lineshape does not provide a reliable estimate of the overall pO2 in the sample. The estimate, depending on the heterogeneity, can be severely biased towards narrow components. To address this issue, we suggest a postprocessing method to recover the linewidth histogram which can be used in estimating meaningful parameters, such as the mean and median pO2 values. This information, although not as comprehensive as obtained by EPR spectral-spatial imaging, goes beyond what can be generally achieved with conventional EPR spectroscopy. Substantially shorter acquisition times, in comparison to EPR imaging, may prompt its use in clinically relevant models. For validation, simulation and EPR experiment data are presented.

  12. Are distribution coefficients measured from batch experiments meaningful for quantifying retention in compacted material?

    Energy Technology Data Exchange (ETDEWEB)

    Goutelard, F.; Charles, Y.; Page, J. [CEA/DEN/DPC/SECR/L3MR batiment 450, 91191 Gif sur Yvette (France)

    2005-07-01

    Full text of publication follows: To quantify the ability of a clayey material to act as a barrier for radionuclides migration, reliable data on retention properties must be available. The most common method for determining the distribution coefficient, quantifying the radionuclide adsorption, is the batch technique applied to powdered solid. Are these data meaningful for highly compacted minerals? This question is still under debate in literature [1,2]. The aim of the present study is to compare distribution coefficient (KD) value for Cs and Ni onto compacted and dispersed for both Bentonite MX80 and Callovo-Oxfordian clayey material in a simulated site water. Firstly, classical batch sorption experiments are carried on dispersed materials pre-conditioned with the simulated site water at pH 7.3. Radiotracer {sup 137}Cs and {sup 58}Ni are used to investigate the constant-pH isotherm sorption. The bottleneck for measuring distribution coefficient onto highly compacted material lies in a careful monitoring of chemical conditions because they are driven by diffusion processes. For this study, we have chosen to use in-diffusion experiments [3]. Sample size is optimized to reach for high retention level (300 mL/g) the steady state in a reasonable time (3 to 6 month). In order to describe the response surface of compacted distribution coefficient on bentonite MX80, a 2 variables Doehlert matrix has been chosen. In this experimental design, the two variables are density and dispersed distribution coefficient. Bentonite is pre-conditioning before compaction to a density ranging from 1.2 to 1.85 kg/l. The pellet is confined in a cylindrical stainless steel filter (150 {mu}L) closed to both ends. The cell is placed in a tightly closed bottle containing the working solution. After a re-equilibration period (at least 3 weeks), {sup 133}Cs and {sup 59}Ni stable isotope are introduced for monitoring the KD level (between 150 mL/g to 330 mL/g). Radiotracer {sup 137}Cs and {sup 58

  13. Are distribution coefficients measured from batch experiments meaningful for quantifying retention in compacted material?

    International Nuclear Information System (INIS)

    Goutelard, F.; Charles, Y.; Page, J.

    2005-01-01

    Full text of publication follows: To quantify the ability of a clayey material to act as a barrier for radionuclides migration, reliable data on retention properties must be available. The most common method for determining the distribution coefficient, quantifying the radionuclide adsorption, is the batch technique applied to powdered solid. Are these data meaningful for highly compacted minerals? This question is still under debate in literature [1,2]. The aim of the present study is to compare distribution coefficient (KD) value for Cs and Ni onto compacted and dispersed for both Bentonite MX80 and Callovo-Oxfordian clayey material in a simulated site water. Firstly, classical batch sorption experiments are carried on dispersed materials pre-conditioned with the simulated site water at pH 7.3. Radiotracer 137 Cs and 58 Ni are used to investigate the constant-pH isotherm sorption. The bottleneck for measuring distribution coefficient onto highly compacted material lies in a careful monitoring of chemical conditions because they are driven by diffusion processes. For this study, we have chosen to use in-diffusion experiments [3]. Sample size is optimized to reach for high retention level (300 mL/g) the steady state in a reasonable time (3 to 6 month). In order to describe the response surface of compacted distribution coefficient on bentonite MX80, a 2 variables Doehlert matrix has been chosen. In this experimental design, the two variables are density and dispersed distribution coefficient. Bentonite is pre-conditioning before compaction to a density ranging from 1.2 to 1.85 kg/l. The pellet is confined in a cylindrical stainless steel filter (150 μL) closed to both ends. The cell is placed in a tightly closed bottle containing the working solution. After a re-equilibration period (at least 3 weeks), 133 Cs and 59 Ni stable isotope are introduced for monitoring the KD level (between 150 mL/g to 330 mL/g). Radiotracer 137 Cs and 58 Ni are used to quantify the

  14. Designing meaningful educational spaces for the development of competencies in childhood

    Directory of Open Access Journals (Sweden)

    Yenny Otálora Sevilla

    2010-11-01

    Full Text Available A meaningful educational space is a learning environment that promotes and strengthens the development of social and cognitive competencies in children. This article offers conceptual and methodological elements from Educational Psychology that facilitates the design of significant educational spaces for the development of child competencies, both in and out of school. On the one hand, the learning environment is defined as a dynamic and complex space of construction of knowledge. On the other it takes into account some considerations about child development which help set five criteria to characterize learning environments as meaningful educational spaces: They are structured, intensive, extensive, generative and interactive situations. Each of these criteria is illustrated through learning environments designed by educators in Colombia, based on the use of cultural practices inherent their communities of origin. Cultural practices were found to be relevant to the development of their children’s competencies.

  15. Meaningful metrics a 21st-century librarian's guide to bibliometrics, altmetrics, and research impact

    CERN Document Server

    Roemer, Robin Chin

    2015-01-01

    What does it mean to have meaningful metrics in today's complex higher education landscape? With a foreword by Heather Piwowar and Jason Priem, this highly engaging and activity-laden book serves to introduce readers to the fast-paced world of research metrics from the unique perspective of academic librarians and LIS practitioners. Starting with the essential histories of bibliometrics and altmetrics, and continuing with in-depth descriptions of the core tools and emerging issues at stake in the future of both fields, Meaningful Metrics is a convenient all-in-one resource that is designed to be used by a range of readers, from those with little to no background on the subject to those looking to become movers and shakers in the current scholarly metrics movement. Authors Borchardt and Roemer, offer tips, tricks, and real-world examples illustrate how librarians can support the successful adoption of research metrics, whether in their institutions or across academia as a whole.

  16. The co-creation of meaningful action: bridging enaction and interactional sociology

    Science.gov (United States)

    Peräkylä, Anssi; Stevanovic, Melisa

    2016-01-01

    What makes possible the co-creation of meaningful action? In this paper, we go in search of an answer to this question by combining insights from interactional sociology and enaction. Both research schools investigate social interactions as such, and conceptualize their organization in terms of autonomy. We ask what it could mean for an interaction to be autonomous, and discuss the structures and processes that contribute to and are maintained in the so-called interaction order. We also discuss the role played by individual vulnerability as well as the vulnerability of social interaction processes in the co-creation of meaningful action. Finally, we outline some implications of this interdisciplinary fraternization for the empirical study of social understanding, in particular in social neuroscience and psychology, pointing out the need for studies based on dynamic systems approaches on origins and references of coordination, and experimental designs to help understand human co-presence. PMID:27069055

  17. Hospital budget increase for information technology during phase 1 meaningful use.

    Science.gov (United States)

    Neumeier, Harold; Berner, Eta S; Burke, Darrell E; Azuero, Andres

    2015-01-01

    Federal policies have a significant effect on how businesses spend money. The 2009 HITECH (Health Information Technology for Economic and Clinical Health Act) authorized incentive payments through Medicare and Medicaid to clinicians and hospitals when they use certified electronic health records privately and securely to achieve specified improvements in care delivery. Federal incentive payments were offered in 2011 for hospitals that had satisfied "meaningful use" criteria. A longitudinal study of nonfederal hospital information technology (IT) budgets (N = 493) during the years 2009 to 2011 found increases in the percentage of hospital annual operating budgets allocated to IT in the years leading up to these federal incentives. This increase was most pronounced among hospitals receiving high proportions of their reimbursements from Medicaid, followed by hospitals receiving high proportions of their reimbursements from Medicare, possibly indicating a budget shift during this period to more IT spending to achieve meaningful-use policy guidelines.

  18. Social networking for language learners: Creating meaningful output with Web 2.0 tools

    Directory of Open Access Journals (Sweden)

    Robert Chartrand

    2012-03-01

    Full Text Available The Internet has the potential to provide language learners with vast resources of authentic written, audio, and video materials to supplement lessons. Educators can find a wide assortment of materials for learners to study in class or after class for independent learning and to encourage learner autonomy. More recently, however, the immense popularity of social networking websites has created new opportunities for language learners to interact in authentic ways that were previously difficult to achieve. Advances in technology mean that today, learners of a language can easily interact with their peers in meaningful practice that helps foster language acquisition and motivation. That is, tasks that make use of Web 2.0 interactivity can significantly raise students’ potential to generate meaningful output and stimulate their interest in language learning.

  19. The Meaningful Roles Intervention: An Evolutionary Approach to Reducing Bullying and Increasing Prosocial Behavior.

    Science.gov (United States)

    Ellis, Bruce J; Volk, Anthony A; Gonzalez, Jose-Michael; Embry, Dennis D

    2016-12-01

    Bullying is a problem that affects adolescents worldwide. Efforts to prevent bullying have been moderately successful at best, or iatrogenic at worst. We offer an explanation for this limited success by employing an evolutionary-psychological perspective to analyze antibullying interventions. We argue that bullying is a goal-directed behavior that is sensitive to benefits as well as costs, and that interventions must address these benefits. This perspective led us to develop a novel antibullying intervention, Meaningful Roles, which offers bullies prosocial alternatives-meaningful roles and responsibilities implemented through a school jobs program and reinforced through peer-to-peer praise notes-that effectively meet the same status goals as bullying behavior. We describe this new intervention and how its theoretical evolutionary roots may be applicable to other intervention programs. © 2015 The Authors. Journal of Research on Adolescence © 2015 Society for Research on Adolescence.

  20. The co-creation of meaningful action: bridging enaction and interactional sociology.

    Science.gov (United States)

    De Jaegher, Hanne; Peräkylä, Anssi; Stevanovic, Melisa

    2016-05-05

    What makes possible the co-creation of meaningful action? In this paper, we go in search of an answer to this question by combining insights from interactional sociology and enaction. Both research schools investigate social interactions as such, and conceptualize their organization in terms of autonomy. We ask what it could mean for an interaction to be autonomous, and discuss the structures and processes that contribute to and are maintained in the so-called interaction order. We also discuss the role played by individual vulnerability as well as the vulnerability of social interaction processes in the co-creation of meaningful action. Finally, we outline some implications of this interdisciplinary fraternization for the empirical study of social understanding, in particular in social neuroscience and psychology, pointing out the need for studies based on dynamic systems approaches on origins and references of coordination, and experimental designs to help understand human co-presence. © 2016 The Authors.