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Sample records for mdp reliable file

  1. MDP: Reliable File Transfer for Space Missions

    Science.gov (United States)

    Rash, James; Criscuolo, Ed; Hogie, Keith; Parise, Ron; Hennessy, Joseph F. (Technical Monitor)

    2002-01-01

    This paper presents work being done at NASA/GSFC by the Operating Missions as Nodes on the Internet (OMNI) project to demonstrate the application of the Multicast Dissemination Protocol (MDP) to space missions to reliably transfer files. This work builds on previous work by the OMNI project to apply Internet communication technologies to space communication. The goal of this effort is to provide an inexpensive, reliable, standard, and interoperable mechanism for transferring files in the space communication environment. Limited bandwidth, noise, delay, intermittent connectivity, link asymmetry, and one-way links are all possible issues for space missions. Although these are link-layer issues, they can have a profound effect on the performance of transport and application level protocols. MDP, a UDP-based reliable file transfer protocol, was designed for multicast environments which have to address these same issues, and it has done so successfully. Developed by the Naval Research Lab in the mid 1990's, MDP is now in daily use by both the US Post Office and the DoD. This paper describes the use of MDP to provide automated end-to-end data flow for space missions. It examines the results of a parametric study of MDP in a simulated space link environment and discusses the results in terms of their implications for space missions. Lessons learned are addressed, which suggest minor enhancements to the MDP user interface to add specific features for space mission requirements, such as dynamic control of data rate, and a checkpoint/resume capability. These are features that are provided for in the protocol, but are not implemented in the sample MDP application that was provided. A brief look is also taken at the status of standardization. A version of MDP known as NORM (Neck Oriented Reliable Multicast) is in the process of becoming an IETF standard.

  2. Evaluation of 99mTc-MDP bone imaging in bone transplantation

    International Nuclear Information System (INIS)

    Liu Sheng; Lu Bin; Chen Shaoxiong

    1995-01-01

    Radionuclide bone imaging was performed to evaluate bone metabolic activity after transplantation with coral combined autologous red marrow and the single coral group. The result was also compared with histological and X-ray examination. This finding revealed that 99m Tc-MDP concentration in the area of the transplanted bone changed dynamically and reached its maximum in 12 weeks following operation and showed various bone metabolic activities with different grafting materials. Clinical application showed that three phase bone imaging could evaluate the blood supply and activity of growing bone of the graft two months earlier than X-ray examination. It was considered that non-accumulation of 99m Tc-MDP in grafted area was a reliable indication of failure in transplantation one month after operation

  3. Performance of PZC-Mo generator and labeling results prepared with its eluate and MDP kit

    International Nuclear Information System (INIS)

    Yishu Liu

    2006-01-01

    This paper described the performance of Tc-99m generator prepared with Mo adsorbent PZC and irradiated nature MoO 3 , and the labeling results of MDP kit prepared with Tc-99m eluted from PZC-Mo generator and MDP was report as well. ThreeTc-99m generators was prepared with different batches of PZC and reactor irradiated nature Mo. The adsorption efficiency of two batches of the PZC is good (96.4% and 93.4%) and that of one batch of PZC is not satisfy (77.8%). The elution efficiency is not so high, and it increases along with the elution date. The elution file is very broad till to 30 ml and the Mo breakthrough is high to unacceptable. The labelling efficiency of MDP kit, prepared with Tc-99m eluate eluted with saline containing 0.05% NaClO from Mo-PZC generator, is approximately 77∼84% and it can reach to >98% labelling with eluate without containing 0.05%HClO in eluate. (author)

  4. Can tumor uptake Tc-99m MDP

    International Nuclear Information System (INIS)

    Yang, Y.S.F.; Zeng, Z.J.; Yao, Y.M.; Shi, S.M.P.; Shi, S.Z.Y.

    2002-01-01

    Aim: To study a distribution of Tc-99m MDP in mice bearing tumor cell lines. Methods: The uptake of Tc-99m MDP was analyzed in seven human tumor cell lines (SPC-A1 adenocarcinoma of lung cancer, P37 Breast cancer, T24 Bladder cancer, SKOV2 Ovary carcinoma, Hela-229 Cervical carcinoma, Osteosarcoma, A375 Melanoma) and one mouse lung cancer cell line (Lewis). They were transplanted into 13, 4, 5, 5, 4, 5 athymic mice, 6 SCID nude mice and 4 C57 black mice, respectively. Approximately 10(7) cells of each cell line were injected subcutaneously into a right chest of mouse. After 5∼6 weeks, the Tc-99m MDP scintigraphy were determined 5-6 hours after i.v. injection of 74MBq in 0.05ml every mouse. Result: Biodistribution and tumor uptake MDP was different in the various cell types investigated. Region of interests (RIOs) placed on a small part of the tumor and horizontal copied to left chest or spine of mice in Tc-99m MDP imaging and the average count ratio (tumor to background ratio: T/B, tumor to spine ratio: T/NT) in each ROI was calculated. 13 nude mice bearing the adenocarcinoma (SPC-A1) were sacrificed and biodistribution was determined after Tc-99m MDP scintigraphy. Results were expressed as % injected dose/gram (%ID/g), mean±SD. T-ulcer=ulcer of tumor, T-round=surrounding of tumor, T-center=the center of tumor, Thor-sp=thoracic spine, Lum-ver=lumbar vertebra, LN=lymph node. Conclusions: Tumor can uptake Tc-99m MDP including adenocarcinoma. Higher uptake rate in the center tissue of tumor is than other part of tumor. It maybe connected with necrosis or fibrosis of tumor

  5. Methylene Diphosphonate Chemical and Biological control of MDP complex

    International Nuclear Information System (INIS)

    Aungurarat, Angkanan; Ngamprayad, Tippanan

    2000-01-01

    Technetium-9 9m MDP easy prepared from MDP kits which different sources such as OAP (In house), SIGMA. The resulting Tc 9 9m -MDP preparations were controlled in chemical and biological tests to compare the different results in these cases: radiochemical purity, the quantity of starting material and biodistribution result

  6. Can tumor uptake Tc-99m MDP ?

    International Nuclear Information System (INIS)

    Yand Shun, Fang; Yao, Ming; Zeng, Jun; Shi Zhen, Yu; Zhao Lan, Xiang; Dong Qiang, Gang

    2003-01-01

    To explore the mechanism of technetium-99m-methylene diphosphonate (MDP) uptake within tumor through analyze a distribution of Tc-99m MDP in mice bearing tumor cell lines. Methods: The uptake of Tc-99m MDP was analyzed in seven human tumor cell lines ( SPC-A1 adenocarcinoma of lung cancer, Bcap-37 Breast cancer, T-24 Bladder cancer, SKOV3 Ovary carcinoma, Hela-229 Cervical carcinoma, SCI-OS Osteosarcoma, SCI-375 Melanoma) and mouse Lewis lung cancer cell line. They were transplanted into athymic mice, SCID nude mice and C57BL/6 mice, respectively. Approximately 10(6) cells of each cell line were injected subcutaneously into a right chest of mouse. After 4 and 5 weeks, the Tc-99m MDP scintigraphy were determined 6 hours after tail vein injection of 74MBq in 0.05ml every mouse. Result: Biodistribution and tumor uptake MDP was different in the various cell types investigated. According to the Region Ratio program of Siemens Power Macintosh 9500 Computer System, region of interests (RIOs) placed on a small part of the tumor and horizontal copied to left background (T/B) and thoracic spine (T/N) of mice in Tc-99m MDP imaging. The average cpm/pixel ratios were calculated by standardized uptake measure (SUM) and determined the tumor-positive value (T/B) greater than or equal to 1.2. T/B of cell lines were sorted from higher to lower as follows: SCI-OS, Lewis, SKOV3, SCI-375, T-24, SPC-A1, Bcap-37, Hela-229. T/N: SCI-OS, SKOV3, T-24, SCI-375, Lewis, SPC-A1, Bcap-37, Hela-229. The biodistribution data of 99Tcm-MDP in SPC-A1 tumor-bearing BALB/c nude mice were given as ID/g and represent the means D (n=13) in 30 hours after injection of Tc-99m MDP. ID/g of major tissue were sorted from higher to lower as follows: thoracic spine, lumbar, ribs, kidneys, the center of tumor, the ulcer of tumor, the surrounding of tumor, lymph node, blood, lungs, heart, liver. Conclusions: Most of tumor can uptake Tc-99m MDP including human adenocarcinoma. The uptake rate in the center tissue of

  7. Simulation-based MDP verification for leading-edge masks

    Science.gov (United States)

    Su, Bo; Syrel, Oleg; Pomerantsev, Michael; Hagiwara, Kazuyuki; Pearman, Ryan; Pang, Leo; Fujimara, Aki

    2017-07-01

    For IC design starts below the 20nm technology node, the assist features on photomasks shrink well below 60nm and the printed patterns of those features on masks written by VSB eBeam writers start to show a large deviation from the mask designs. Traditional geometry-based fracturing starts to show large errors for those small features. As a result, other mask data preparation (MDP) methods have become available and adopted, such as rule-based Mask Process Correction (MPC), model-based MPC and eventually model-based MDP. The new MDP methods may place shot edges slightly differently from target to compensate for mask process effects, so that the final patterns on a mask are much closer to the design (which can be viewed as the ideal mask), especially for those assist features. Such an alteration generally produces better masks that are closer to the intended mask design. Traditional XOR-based MDP verification cannot detect problems caused by eBeam effects. Much like model-based OPC verification which became a necessity for OPC a decade ago, we see the same trend in MDP today. Simulation-based MDP verification solution requires a GPU-accelerated computational geometry engine with simulation capabilities. To have a meaningful simulation-based mask check, a good mask process model is needed. The TrueModel® system is a field tested physical mask model developed by D2S. The GPU-accelerated D2S Computational Design Platform (CDP) is used to run simulation-based mask check, as well as model-based MDP. In addition to simulation-based checks such as mask EPE or dose margin, geometry-based rules are also available to detect quality issues such as slivers or CD splits. Dose margin related hotspots can also be detected by setting a correct detection threshold. In this paper, we will demonstrate GPU-acceleration for geometry processing, and give examples of mask check results and performance data. GPU-acceleration is necessary to make simulation-based mask MDP verification

  8. Enhancement of Muramyldipeptide (MDP) Immunostimulatory Activity by Controlled Multimerization on Dendrimers

    DEFF Research Database (Denmark)

    Sørensen, Nanna Skall; Boas, Ulrik; Heegaard, Peter M. H.

    2011-01-01

    Peptidoglycan is a widespread bacterial PAMP molecule and a powerful initiator of innate immune responses. It consists of repeating units of MDP, which as a monomer is only weakly immunostimulatory. Here, MDP-coupled dendrimers were prepared and investigated for stimulation of pig blood mononuclear...... cells. Compared to monomeric MDP, MDP-dendrimers induced a markedly enhanced production of IL-12 p40, IL-1β and IL-6 and completely down-regulated surface expression of B7 and MHC class II. These results suggest a possible novel strategy based on controlled multimerization of minimal PAMP motifs...... on dendrimers for preparing molecularly defined immunostimulators with predictable bioactivities....

  9. Therapeutic effect of 99Tc - MDP observed in the treatment of rheumatoid arthritis

    International Nuclear Information System (INIS)

    Sang Shibiao; Wu Yiwei; Su Chenghai; Zhang Wei; Dong Shenan

    2003-01-01

    Objective: To evaluate the therapeutic effect and safety of 99 Tc - MDP in the treatment of rheumatoid arthritis (RA). Methods: Two hundred and eight patients with active RA have been treated using 99 Tc - MDP. The clinical manifestation and laboratory examination before and after treatment were observed. Results: The total effective rate of the 99 Tc - MDP was 86.1%. The effectiveness of relieving pain, diminishing swelling, increasing immune function etc was significant. It was most effective in improving morning stiffness, limitation of articulation function and decreasing ESR. Conclusion: The clinical effect of the 99 Tc - MDP is obvious. Application of the 99 Tc - MDP is safety, no significant adverse action and worth clinical using

  10. Accumulation of sup(99m)Tc-MDP in pleural effusions and ascites

    International Nuclear Information System (INIS)

    Yokomizo, Yu; Ichiya, Yuichi; Kuwabara, Yasuo; Wada, Makoto; Shiozaki, Hiroshi

    1983-01-01

    In 1500 cases bone scintigraphy was performed. sup(99m)Tc-MDP accumulation were revealed on bone scintigraphy in pleural effusion in 5 cases and that in ascitic effusion in 2 cases. The sensitivity of sup(99m)Tc-MDP accumulation was 5.5% for pleural effusion and 10.0% for ascites. It was noticed that the sup(99m)Tc-MDP accumulation was often associated with retention of a large amount of pleural effusion. (Ueda, J.)

  11. Modular toolkit for Data Processing (MDP: a Python data processing framework

    Directory of Open Access Journals (Sweden)

    Tiziano Zito

    2009-01-01

    Full Text Available Modular toolkit for Data Processing (MDP is a data processing framework written in Python. From the user's perspective, MDP is a collection of supervised and unsupervised learning algorithms and other data processing units that can be combined into data processing sequences and more complex feed-forward network architectures. Computations are performed efficiently in terms of speed and memory requirements. From the scientific developer's perspective, MDP is a modular framework, which can easily be expanded. The implementation of new algorithms is easy and intuitive. The new implemented units are then automatically integrated with the rest of the library. MDP has been written in the context of theoretical research in neuroscience, but it has been designed to be helpful in any context where trainable data processing algorithms are used. Its simplicity on the user's side, the variety of readily available algorithms, and the reusability of the implemented units make it also a useful educational tool.

  12. Is 99mTc-MDP mammoscintigraphy useful in patients with breast mass lesions?

    International Nuclear Information System (INIS)

    Park, S. K.; Lee, Y. H.; Rhyu, J. W.; Yoo, S. M.

    1998-01-01

    Piccolo et al. advocated the usefulness of 99m Tc-MDP breast scan in differential diagnosis of breast mass with high accuracy. But there are little or no follow-up studies about it as we know. We studied 99m Tc-MDP uptake pattern and lesion/background ratio in patients complaining palpable breast lesions to evaluate the clinical usefulness of 99m Tc-MDP scan. Total 34 patients were studied with physical examination, mammogram and 99m Tc-MDP scan prospectively. Anteroposterior and both lateral view of breast were obtained 5 minutes after iv injection of 740 MBq 99m Tc-MDP. Breast uptake pattern of 99m Tc-MDP was analyzed by a grade system: 0=no uptake, grade 1=bilateral diffuse uptake, grade 2=asymmetric faint uptake, grade 3=focal hot uptake. 20 cases were pathologically confirmed by excision biopsy or aspiration biopsy. 14 cases were normal in physical examination and mammogram. Pathologic results showed 7 carcinomas, 6 benign solid tumors, and 7 fibrocystic changes. Grade 3 pattern of 99m Tc-MDP uptake was noted in 4/7 carcinomas, 3/5 benign solid tumors, and 1/7 fibrocystic changes. Grade 2 pattern was 2/7, 0/7, 3/7 respectively. The average L/B ratio was 1.66 in carcinomas, 1.68 in benign solid masses, 1.20 in fibrocystic diseases, 1.05 in normal patients. L/B ratio was higher in carcinoma and benign mass groups than in fibrocystic change and normal control groups(p=0.005). But there was no statistical difference between L/B ratio of malignant mass group and benign mass group. 99m Tc-MDP scan is not suitable to routine clinical use for breast mass diagnosis. It might be used in limited conditions when whole body bone scan is planned

  13. 78 FR 21929 - Transmission Relay Loadability Reliability Standard; Notice of Compliance Filing

    Science.gov (United States)

    2013-04-12

    ... Relay Loadability Reliability Standard; Notice of Compliance Filing Take notice that on February 19... Relay Loadability Reliability Standard, Order No. 733, 130 FERC ] 61,221 (2010) (Order No. 733); order..., 136 FERC ] 61,185 (2011). \\2\\ Transmission Relay Loadability Reliability Standard, 138 FERC ] 61,197...

  14. 78 FR 55249 - Transmission Relay Loadability Reliability Standard; Notice of Compliance Filing

    Science.gov (United States)

    2013-09-10

    ...; RM11-16-000] Transmission Relay Loadability Reliability Standard; Notice of Compliance Filing Take.... \\1\\ Transmission Relay Loadability Reliability Standard, Order No. 733, 130 FERC ] 61, 221 (2010..., Order No. 733-B, 136 FERC ] 61,185 (2011). \\2\\ Transmission Relay Loadability Reliability Standard, 138...

  15. Is {sup 99m}Tc-MDP mammoscintigraphy useful in patients with breast mass lesions?

    Energy Technology Data Exchange (ETDEWEB)

    Park, S. K.; Lee, Y. H.; Rhyu, J. W.; Yoo, S. M. [College of Medicine, Dankook Univ., Cheonan (Korea, Republic of)

    1998-06-01

    Piccolo et al. advocated the usefulness of {sup 99m}Tc-MDP breast scan in differential diagnosis of breast mass with high accuracy. But there are little or no follow-up studies about it as we know. We studied {sup 99m}Tc-MDP uptake pattern and lesion/background ratio in patients complaining palpable breast lesions to evaluate the clinical usefulness of {sup 99m}Tc-MDP scan. Total 34 patients were studied with physical examination, mammogram and {sup 99m}Tc-MDP scan prospectively. Anteroposterior and both lateral view of breast were obtained 5 minutes after iv injection of 740 MBq {sup 99m}Tc-MDP. Breast uptake pattern of {sup 99m}Tc-MDP was analyzed by a grade system: 0=no uptake, grade 1=bilateral diffuse uptake, grade 2=asymmetric faint uptake, grade 3=focal hot uptake. 20 cases were pathologically confirmed by excision biopsy or aspiration biopsy. 14 cases were normal in physical examination and mammogram. Pathologic results showed 7 carcinomas, 6 benign solid tumors, and 7 fibrocystic changes. Grade 3 pattern of {sup 99m}Tc-MDP uptake was noted in 4/7 carcinomas, 3/5 benign solid tumors, and 1/7 fibrocystic changes. Grade 2 pattern was 2/7, 0/7, 3/7 respectively. The average L/B ratio was 1.66 in carcinomas, 1.68 in benign solid masses, 1.20 in fibrocystic diseases, 1.05 in normal patients. L/B ratio was higher in carcinoma and benign mass groups than in fibrocystic change and normal control groups(p=0.005). But there was no statistical difference between L/B ratio of malignant mass group and benign mass group. {sup 99m}Tc-MDP scan is not suitable to routine clinical use for breast mass diagnosis. It might be used in limited conditions when whole body bone scan is planned.

  16. Indirect spectrophotometric determination of BIDA, DISIDA, DTPA and MDP in labelled compounds

    International Nuclear Information System (INIS)

    Van der Walt, T.N.; Coetzee, P.P.

    1989-01-01

    N-(4-(n-butyl)acetanilide)iminodiacetic acid (BIDA), N-(2,6-diisopropylacetanilide)iminodiacetic acid (DISDA), diethylenetriaminepentaacetic acid (DTPA) and methylene diphosphonic acid (MDP) are used in labelling kits. The contents of BIDA, DISIDA or MDP of the 99m Tc-labelled compounds can be determined (indirectly) spectrophotometrically with copper, eriochrome cyanine R (ECC) and dodecyl-ethyldimethylammonium bromide (DEDA) in a sodium barbital buffered system at pH 8.5. The calibration curves obey Beer's Law from 0 to 40 μg/25 mL for BIDA and DISIDA, 0 to 60 μg/25 mL for DTPA and 0 to 100 μg/10 mL for MDP. (author)

  17. Gene mdpC plays a regulatory role in the methyl-tert-butyl ether degradation pathway of Methylibium petroleiphilum strain PM1.

    Science.gov (United States)

    Joshi, Geetika; Schmidt, Radomir; Scow, Kate M; Denison, Michael S; Hristova, Krassimira R

    2015-04-01

    Among the few bacteria known to utilize methyl tert-butyl ether (MTBE) as a sole carbon source, Methylibium petroleiphilum PM1 is a well-characterized organism with a sequenced genome; however, knowledge of the genetic regulation of its MTBE degradation pathway is limited. We investigated the role of a putative transcriptional activator gene, mdpC, in the induction of MTBE-degradation genes mdpA (encoding MTBE monooxygenase) and mdpJ (encoding tert-butyl alcohol hydroxylase) of strain PM1 in a gene-knockout mutant mdpC(-). We also utilized quantitative reverse transcriptase PCR assays targeting genes mdpA, mdpJ and mdpC to determine the effects of the mutation on transcription of these genes. Our results indicate that gene mdpC is involved in the induction of both mdpA and mdpJ in response to MTBE and tert-butyl alcohol (TBA) exposure in PM1. An additional independent mechanism may be involved in the induction of mdpJ in the presence of TBA. © FEMS 2015. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

  18. Effect of neurotrophic factor, MDP, on rats’ nerve regeneration

    Directory of Open Access Journals (Sweden)

    A.A. Fornazari

    2011-04-01

    Full Text Available Our objective was to determine the immune-modulating effects of the neurotrophic factor N-acetylmuramyl-L-alanyl-D-isoglutamine (MDP on median nerve regeneration in rats. We used male Wistar rats (120-140 days of age, weighing 250-332 g and compared the results of three different techniques of nerve repair: 1 epineural neurorrhaphy using sutures alone (group S - 10 rats, 2 epineural neurorrhaphy using sutures plus fibrin tissue adhesive (FTA; group SF - 20 rats, and 3 sutures plus FTA, with MDP added to the FTA (group SFM - 20 rats. Functional assessments using the grasp test were performed weekly for 12 weeks to identify recovery of flexor muscle function in the fingers secondary to median nerve regeneration. Histological analysis was also utilized. The total number and diameter of myelinated fibers were determined in each proximal and distal nerve segment. Two indices, reported as percentage, were calculated from these parameters, namely, the regeneration index and the diameter change index. By the 8th week, superiority of group SFM over group S became apparent in the grasping test (P = 0.005. By the 12th week, rats that had received MDP were superior in the grasping test compared to both group S (P < 0.001 and group SF (P = 0.001. Moreover, group SF was better in the grasping test than group S (P = 0.014. However, no significant differences between groups were identified by histological analysis. In the present study, rats that had received MDP obtained better function, in the absence of any significant histological differences.

  19. Accumulation of 99Tcm MDP in lung cancer of 84 patients

    International Nuclear Information System (INIS)

    Yang, Y.S.F.; Zeng, Z.J.; Shao, S.J.L.; Shi, S.M.P.; Zheng, Z.Z.C.

    2002-01-01

    Objective: To analyze the clinic mechanisms of technetium-99m-methyl-diphosphate ( 99 Tc m -MDP) uptake in lung cancer. Methods: 84 patients (63 men, 21 women; mean age 61.56 years) with lung cancer and no effusion underwent bone scan. Of 84, there were primary lung cancer in 63 cases and metastatic lung cancer in 21 cases. 28 adenocarcinomas, 32 squamous carcinomas, 9 adenosquamous carcinomas, 9 non-classified non-small cell lung cancers, 6 small cell lung carcinomas. Final diagnoses were established by histology in all patients. The bone scan was performed 3-8h after i.v. injection of 1295MBq 99 Tc m -MDP. The whole body scan was performed using a SPET camera (MULTISPECT2, Siemans) and the scan speed was 11cm/min. Tracer uptake was visual and semi-quantitative analyzed for each patient. The expression of 99 Tc m -MDP uptake in lung was determined the intensity and then took semi-quantitative analysis of 99 Tc m -MDP uptake, regions of interest (RIOs) placed on the lesions encompassed all pixels and horizontal copied to normal lung in anterior and posterior view, and the average count ratio (tumor to normal lung T/N) in each ROI was calculated. We analyzed the ratio by computing the standardized uptake measures (SUMs) to determine the tumor-positive value (T/N) greater than or equal to 1.2. All 99 Tc m -MDP images were carefully compared with their contemporaneous chest roentgenograms, CT and histopathology studies. Results: For statistics analysis of the 99 Tc m -MDP uptake in lung cancer, the men were 81% in 63 cases, women 19% in 21; the age of less than or equal to fifty years old is 12% in 10; poorly differentiated carcinoma was 48.8% in 41, med-differentiated carcinoma was 39.3% in 33 and differentiated was 11.9% in 10;the patients of chemotherapy were 32.1% in 27; the metastatic lymph nodules were 51.2% in 43; the diameter of tumor with larger than 5 cm was 72.4% in 60;pleura involvement was 83.7% in 36; necrosis was 76.8% in 33; abnormality of enzyme (GPT

  20. Indirect spectrophotometric determination of BIDA, DISIDA, DTPA and MDP in labelled compounds

    Energy Technology Data Exchange (ETDEWEB)

    Van der Walt, T.N.; Coetzee, P.P. (Rand Afrikaans Univ., Johannesburg (South Africa). Dept. of Chemistry); Fourie, P.J. (Atomic Energy Corp. of South Africa (Pty) Ltd., Pretoria (South Africa))

    1989-01-01

    N-(4-(n-butyl)acetanilide)iminodiacetic acid (BIDA), N-(2,6-diisopropylacetanilide)iminodiacetic acid (DISDA), diethylenetriaminepentaacetic acid (DTPA) and methylene diphosphonic acid (MDP) are used in labelling kits. The contents of BIDA, DISIDA or MDP of the {sup 99m}Tc-labelled compounds can be determined (indirectly) spectrophotometrically with copper, eriochrome cyanine R (ECC) and dodecyl-ethyldimethylammonium bromide (DEDA) in a sodium barbital buffered system at pH 8.5. The calibration curves obey Beer's Law from 0 to 40 {mu}g/25 mL for BIDA and DISIDA, 0 to 60 {mu}g/25 mL for DTPA and 0 to 100 {mu}g/10 mL for MDP. (author).

  1. Study on the preparation of methylene diphosphonate (MDP) labeling with 99mTc for bone scintigraphy

    International Nuclear Information System (INIS)

    Nguyen Thi Thu; Le Van So; Vo Thi Cam Hoa; Bui Van Cuong; Mai Phuoc Tho; Pham Ngoc Dien; Duong Van Dong; Chu Van Khoa

    2005-01-01

    The 99m Tc-MDP kit was prepared by using aseptic technique. The composition of MDP invivo kit including 5 mg MDP, 0.5 mg stannous chloride, 0.5 mg ascorbic acid and 5 mg sodium chloride. The kit produces 99m Tc-MDP with more than 95% labelling efficiency at pH 6-7 when mixed with requisite amount of 99m Tc-pertechnetate. The preparation has been found sterity, pyrogen free, to be sufficiency stable invitro as well as invivo, blood clearance. After intravenous administrations abound 50% of the dose is accumulated and retained by the skeleton. The kit provides quality product in high yield, more stable than other phosphonate kit, high bone uptake. High avidity of 99m Tc-MDP for bone imaging makes it a promising agent for the detection of bone diseases. (author)

  2. Reliable file sharing in distributed operating system using web RTC

    Science.gov (United States)

    Dukiya, Rajesh

    2017-12-01

    Since, the evolution of distributed operating system, distributed file system is come out to be important part in operating system. P2P is a reliable way in Distributed Operating System for file sharing. It was introduced in 1999, later it became a high research interest topic. Peer to Peer network is a type of network, where peers share network workload and other load related tasks. A P2P network can be a period of time connection, where a bunch of computers connected by a USB (Universal Serial Bus) port to transfer or enable disk sharing i.e. file sharing. Currently P2P requires special network that should be designed in P2P way. Nowadays, there is a big influence of browsers in our life. In this project we are going to study of file sharing mechanism in distributed operating system in web browsers, where we will try to find performance bottlenecks which our research will going to be an improvement in file sharing by performance and scalability in distributed file systems. Additionally, we will discuss the scope of Web Torrent file sharing and free-riding in peer to peer networks.

  3. 78 FR 44557 - Revision to Transmission Vegetation Management Reliability Standard; Notice of Compliance Filing

    Science.gov (United States)

    2013-07-24

    ... Transmission Vegetation Management Reliability Standard; Notice of Compliance Filing Take notice that on July 12, 2013, the North American Electric Reliability Corporation (NERC), pursuant to Order No. 777 \\1... Reliability Standard FAC-003-2 to its Web site. \\1\\ Revisions to Reliability Standard for Transmission...

  4. Incidental Diagnosis of Carcinoma of the Bladder Due to Uptake of 99mTc-MDP

    International Nuclear Information System (INIS)

    Damle, Nishikant A; Pandey, Dinesh Chand; Gautam, Awadhesh Kumar; Subbarao, Kiran; Singh, Prabhjot; Mishra, Rohini; Das, Nitendra Lal; Pandey, Dinesh Chand; Gautam, Awadhesh Kumar

    2012-01-01

    A bone scan was per-formed using 740 MBq (29 mCi) 99 mTc-MDP. Whole-body planar images were acquired 3 h after injection (Fig. 1). Soft tissue uptake of 99 mTc-MDP is described in various benign and malignant conditions. It is known to accumulate in adenocarcinoma of lung, primary breast cancer, and colonic carcinoma among others. The postulated causes of 99 mTc-MDP uptake in extraosseous neoplasms are numerous and include tumor vascularity, inflammation, local pH factors, altered calcium metabolism, hormonal influences and cell wall damage. Our case shows that TCC of the bladder was incidentally diagnosed due to MDP uptake in multiple bladder polyps detected on a bone scan done for low backache in an 80-year-old man

  5. Intravitreal injection of (99)Tc-MDP inhibits the development of laser-induced choroidal neovascularization in rhesus monkeys.

    Science.gov (United States)

    Lai, Kunbei; Jin, Chenjin; Tu, Shu; Xiong, Yunfan; Huang, Rui; Ge, Jian

    2014-07-01

    The aim of this study was to investigate the safety and efficacy of intravitreal injection of (99)Tc-MDP, a decay product of (99m)Tc-MDP, on the development of laser-induced choroidal neovascularization (CNV) in rhesus monkeys. Experimental CNV was induced by argon laser with a small high-energy laser spot. Monkeys were given 50 μL of (99)Tc-MDP at a concentration of 0.005 μg/mL (n = 6) or 0.01 μg/mL (n = 6) by intravitreal injection once a week immediately after laser injury for a period of 56 days. Control animals were treated with the same volume of PBS (n = 6) in the same way. Eyes were monitored by ophthalmic examination, color fundus photography, fluorescence fundus angiography (FFA), optical coherence tomography (OCT) and histology. Incidences of grade 4 CNV lesions as well as the leakage areas of grade 4 CNVs on the late-phase of fluorescein angiograms were measured in a standardized, randomized and masked fashion fortnightly. The maximum widths and heights of grade 4 CNVs were also calculated by histology at the end of the experiment. Toxicity of (99)Tc-MDP on the retina was evaluated by electroretinogram (ERG) and histologic analysis. (99)Tc-MDP reduced the incidences of grade 4 CNVs by 33.33 % and 39.40 % in the 0.005 μg/mL and 0.01 μg/mL groups, respectively, compared with the PBS group on day 28 (P 99)Tc-MDP treated groups than those in the PBS group. Although intravitreal injection of (99)Tc-MDP led to mild inflammatory reaction in the anterior chamber, histology and ERG findings demonstrated that (99)Tc-MDP did not cause any change in histological structure or function of the retina (p>0.05). Intravitreal injection of (99)Tc-MDP can inhibit the development of laser-induced CNV without toxic effect on retina, suggesting that (99)Tc-MDP has therapeutic potential for CNV related diseases.

  6. Twelve reasons to refuse the nuclear in the MDP

    International Nuclear Information System (INIS)

    Bonduelle, A.

    2000-01-01

    The author presents twelve reasons which show that the nuclear energy has not a place in the MDP Mechanism of Clean Development: a main loophole for the developed countries, the doubtful ''additionality'' of the nuclear, the treaty ratification is more difficult with the nuclear, the domestic energy conservation is more efficient in Europe than the nuclear development, the nuclear white elephants facing the South debts, the technology transfers are doubtful, the developing countries and the sustainable development policies are evicted from the MDP, some options are more powerful in the South, the reactors and transport networks size are unsuited, the absence of democratic control, the nuclear proliferation, the nuclear safety and the wastes. (A.L.B.)

  7. Changes in renal uptake of Tc-99m methylene diphosphonate (MDP) in stone-forming rats

    International Nuclear Information System (INIS)

    McAfee, J.G.; Thomas, F.D.; Roskopf, M.; Ritter, K.; Lyons, B.; Lilien, O.M.; Schoonmaker, J.E.

    1984-01-01

    A pyridoxine (vitamin B6)-deficient diet in rats was used as a model of early renal lithiasis to find out if stone-formers could be identified from control animals by differences in the biodistribution of Tc-99m MDP. The mean renal uptake of this agent at 3 hours was about 70% higher in test animals than in controls, but there was considerable overlap between the upper limits of the normal range and lower values in stone-formers. If these results were valid for humans, the metabolic abnormality in males with early stone-forming disease could not be identified with certainty by in vivo measurements of Tc-99m MDP renal uptake alone. However, the skeletal uptake of MDP in the stone-forming animals was depressed by 28 to 35%, compared with control rats. Consequently, the renal to skeletal MDP concentration ratio was invariably elevated in stone-formers beyond the 95 percentile normal range. Unexpectedly, 76% of the pyridoxine-deficient animals had a higher accumulation of MDP in the myocardium than the upper limit of the normal range. The pyridoxine-deficient diet induced no remarkable early changes in the biodistribution or renal clearance of I-131 Hippuran

  8. Comparison of 99mTc-MDP SPECT qualitative vs quantitative results in patients with suspected condylar hyperplasia.

    Science.gov (United States)

    López Buitrago, D F; Ruiz Botero, J; Corral, C M; Carmona, A R; Sabogal, A

    To compare qualitative vs quantitative results of Single Photon Emission Computerised Tomography (SPECT), calculated from percentage of 99m Tc-MDP (methylene diphosphonate) uptake, in condyles of patients with a presumptive clinical diagnosis of condylar hyperplasia. A retrospective, descriptive study was conducted on the 99m Tc-MDP SPECT bone scintigraphy reports from 51 patients, with clinical impression of facial asymmetry related to condylar hyperplasia referred by their specialist in orthodontics or maxillofacial surgery, to a nuclear medicine department in order to take this type of test. Quantitative data from 99m Tc-MDP condylar uptake of each were obtained and compared with qualitative image interpretation reported by a nuclear medicine expert. The concordances between the 51 qualitative and quantitative reports results was established. The total sample included 32 women (63%) and 19 men (37%). The patient age range was 13-45 years (21±8 years). According to qualitative reports, 19 patients were positive for right side condylar hyperplasia, 12 for left side condylar hyperplasia, with 8 bilateral, and 12 negative. The quantitative reports diagnosed 16 positives for right side condylar hyperplasia, 10 for left side condylar hyperplasia, and 25 negatives. Nuclear medicine images are an important diagnostic tool, but the qualitative interpretation of the images is not as reliable as the quantitative calculation. The agreement between the two types of report is low (39.2%, Kappa=0.13; P>.2). The main limitation of quantitative reports is that they do not register bilateral condylar hyperplasia cases. Copyright © 2017 Elsevier España, S.L.U. y SEMNIM. All rights reserved.

  9. Mechanism for a clean development (MDP)

    International Nuclear Information System (INIS)

    2003-01-01

    The mechanism of clean development (MDP) aims to favor the fight against the climatic change, by the implementing of activities, technologies and appropriate techniques emitting less greenhouse gases in south countries and by the possibility of reducing the greenhouse gases emissions for a more economical cost. This guide is a practical help for the project set-up: formalization, methodology and contract. (A.L.B.)

  10. Incidental Diagnosis of Carcinoma of the Bladder Due to Uptake of {sup 99m}Tc-MDP

    Energy Technology Data Exchange (ETDEWEB)

    Damle, Nishikant A; Pandey, Dinesh Chand; Gautam, Awadhesh Kumar; Subbarao, Kiran; Singh, Prabhjot [All India Institute of Medical Sciences, New Delhi (India); Mishra, Rohini; Das, Nitendra Lal; Pandey, Dinesh Chand; Gautam, Awadhesh Kumar [B. L. Kapur Memorial Hospital, New Delhi (India)

    2012-06-15

    A bone scan was per-formed using 740 MBq (29 mCi) {sup 99}mTc-MDP. Whole-body planar images were acquired 3 h after injection (Fig. 1). Soft tissue uptake of {sup 99}mTc-MDP is described in various benign and malignant conditions. It is known to accumulate in adenocarcinoma of lung, primary breast cancer, and colonic carcinoma among others. The postulated causes of {sup 99}mTc-MDP uptake in extraosseous neoplasms are numerous and include tumor vascularity, inflammation, local pH factors, altered calcium metabolism, hormonal influences and cell wall damage. Our case shows that TCC of the bladder was incidentally diagnosed due to MDP uptake in multiple bladder polyps detected on a bone scan done for low backache in an 80-year-old man.

  11. 99m Tc-MDP deposition in testes

    International Nuclear Information System (INIS)

    Calegaro, J.U.M.; Carvalho, A.C.M. de

    A case of 99m Tc-MDP deposition in the testes of a patient who was submmited to therapeutic orquiectomy for prostatic adenocarcinoma six years ago, during bone scintigraphy, is reported. A brief review of the pertinent literature has been made with discussion of the possible mechanism justifying the finding. (Author) [pt

  12. Age-related normal uptake of {sup 99m}Tc-MDP in the lower spine

    Energy Technology Data Exchange (ETDEWEB)

    Sundkvist, G.M.G. [Dept. of Clinical Physiology, Centralsjukhuset, Kristianstad (Sweden); Lilja, B. [Dept. of Clinical Physiology, Universitetssjukhuset MAS, Malmoe (Sweden); Mattsson, S. [Dept. of Radiation Physics, Universitetssjukhuset MAS, Malmoe (Sweden)

    1997-03-01

    Aim: The uptake of {sup 99m}Tc-MDP in the lower spine was quantified in connection with ordinary bone scintigraphy. Methods: Fifty-seven women and seventy-two men (aged 20-69 y), with no signs of metabolic or malignant disease and no history of back pain or atraumatic fractures, were included in the study. Results: The women showed an increase in {sup 99m}Tc-MDP uptake from the age of 20 y to about 45 y with a decrease from the time of menopause. In contrast to women, the uptake in men showed a slight decrease from the age of 20 y to about 50 y and thereafter a more marked decrease was seen. The major difference between men and women is the high premenopausal uptake in the female skeleton. Conclusion: An understanding of age-related changes in {sup 99m}Tc-MDP uptake, which are indices of the skeletal metabolism, is of importance especially in prevention and treatment of osteoporosis, a common disorder in postmenopausal women. (orig.) [Deutsch] Ziel: In Verbindung mit einer routinemaessigen Skelettszintigraphie wurde die Speicherung von {sup 99m}Tc-MDP in der unteren Wirbelsaeule quantifiziert. Methoden: 57 Frauen und 22 Maenner (Alter von 20-69 Jahren) ohne metabolische oder boesartige Erkrankungen sowie ohne Rueckenschmerzen oder Wirbelsinterungen wurden in die Studien aufgenommen. Ergebnisse: Bei Frauen zeigte sich ein Anstieg der {sup 99m}Tc-MDP-Speicherung zwischen den Altersabschnitten 20 bis 45 Jahre und dann ein Abfall waehrend der Menopause. Im Gegensatz hierzu zeigte sich bei Maennern ein leichter Abfall der Speicherung vom 20. bis 50. Lebensjahr und danach eine noch staerkere Abnahme. Der Hauptunterschied zwischen den Geschlechtern ist die relativ hohe Speicherung im weiblichen Skelett praemenopausal. Schlussfolgerung: Das Verstaendnis der Altersbeziehungen der {sup 99m}Tc-MDP-Speicherung als Indikator des Knochenstoffwechsels ist fuer Praevention und Behandlung der postmenopausalen Osteoporose wichtig. (orig.)

  13. Comparison of sup(99m)Tc-MDP to sup(99m)Tc-pertechnetate by computerized quantitative joint scintigraphy

    International Nuclear Information System (INIS)

    Rekonen, A.; Moettoenen, T.; Oka, M.

    1982-01-01

    99mTc-pertechnetate was compared to 99mTc-MDP in joint pairs with asymmetric arthritis. Markedly elevated joint activity ratios (inflamed/uninflamed joint) were measured in all the joint pairs studied. In the joints affected by reactive arthritis and without roentgenologic changes the mean joint activity was the same with both tracers. A very high activity ratio with 99mTc-MDP was found in septic arthritis. In rheumatoid arthritis the sensitivity of 99mTc-MDP as an indicator of active arthritis seemed to be better than that of 99mTc-pertechnetate. Even in joints without erosions in roentgenograms the joint activity ratios were markedly elevated with 99mTc-MDP. This suggests, that high activity in 99mTc-MDP scanning might be prognostic of erosive joint changes. In this work a profile curve was used for quantitation differences between joints

  14. Labeling of MDP with 188Re for bone tumour therapy

    International Nuclear Information System (INIS)

    Barbezan, Angelica B.; Osso Junior, Joao A.

    2011-01-01

    188 Re is one of the most attractive radioisotopes for a variety of therapeutic applications in nuclear medicine, due to its physical decay properties, such as β - emission of 2.12 MeV, γ emission of 155 keV and half life of 16.9 hours. Biphosphonates are potent inhibitors of osteoclastic bone resorption and are effective in several diseases that cause bone fragility and bone metastases. Because of these characteristics, labeled biphosphonates have been studied for bone pathologies, also acting as palliation of bone pain in case of metastasis.The aim of this study was to optimize the labeling of a phosphonate-MDP (Sodium Methylene Diphosphonate) with 188 Re for use in bone pain palliation. 188 Re was obtained by eluting a 188 W- 188 Re generator from POLATOM. The labeling was performed at room temperature using MDP, SnCl 2 as reducing agent and ascorbic acid. The variables studied were: Mass of ligand (3, 6 and 10 mg), reducing agent mass (5, 7, 10 and 11 mg), ascorbic acid mass (1, 3, 5 and 6 mg), pH (1 and 2) and time of reaction (15, 60, 120, 360 and 4320 minutes), that also reflected the stability of the radiopharmaceutical. The radiochemical control, that also measures the labeling efficiency was evaluated by paper chromatography using Whatman 3MM paper and the solvents acetone and 0.9%NaCl. The best formulation was the following: Mass of ligand MDP: 10 mg, mass of SnCl 2 : 5 mg, ascorbic acid mass: 3 mg, time of reaction: 30 minutes, pH: 1. Under optimum conditions, 188 Re MDP radiolabeling yield was 98,07% and the radiopharmaceutical was stable up to 72 h. (author)

  15. Biokinetics of osteotropic radiopharmaceuticals in metabolic osteopathies - comparison of 47Ca and sup(99m)Tc-MDP

    International Nuclear Information System (INIS)

    Knop, J.; Montz, R.

    1983-01-01

    Plasma clearance and osseous accumulation rates of sup(99m)Tc methylene diphosphonate (MDP) in the lumbar spine were measured in 11 patients with osteoporosis (OP), 7 patients with hyperparathyroidism (HPT), 4 patients with osteomalacia (OM) and in 3 patients (N) who were studied to exclude metabolic bone disease. The findings in 19 patients were compared with the results of 47 Ca kinetics. The plasma elimination of sup(99m)Tc-MDP during the first hour after application was normal in almost all the patients. The sup(99m)Tc-MDP accumulation rates in the lumbar spine were raised in patients with HPT and OM (p 0,05). 47 Ca kinetics were disturbed in most of the patients with metabolic bone disease, with minimal deviations in OP. The comparison of sup(99m)Tc-MDP accumulation rates with the results of 47 Ca kinetics revealed significant correlations with exchangeable bone and soft tissue calcium. The correlations with total calcium turnover and calcium accretion were poor. Only half of the patients had equal results of sup(99m)Tc-MDP accumulation rates and bone calcium accretion rates. It is concluded that the sup(99m)Tc-MDP uptake by bone is an index of bone metabolism presumably of the organic matrix, whereas 47 Ca kinetics represent the mineral metabolism of bone. (orig.) [de

  16. Involvement of a novel enzyme, MdpA, in methyl tert-butyl ether degradation in Methylibium petroleiphilum PM1.

    Science.gov (United States)

    Schmidt, Radomir; Battaglia, Vince; Scow, Kate; Kane, Staci; Hristova, Krassimira R

    2008-11-01

    Methylibium petroleiphilum PM1 is a well-characterized environmental strain capable of complete metabolism of the fuel oxygenate methyl tert-butyl ether (MTBE). Using a molecular genetic system which we established to study MTBE metabolism by PM1, we demonstrated that the enzyme MdpA is involved in MTBE removal, based on insertional inactivation and complementation studies. MdpA is constitutively expressed at low levels but is strongly induced by MTBE. MdpA is also involved in the regulation of tert-butyl alcohol (TBA) removal under certain conditions but is not directly responsible for TBA degradation. Phylogenetic comparison of MdpA to related enzymes indicates close homology to the short-chain hydrolyzing alkane hydroxylases (AH1), a group that appears to be a distinct subfamily of the AHs. The unique, substrate-size-determining residue Thr(59) distinguishes MdpA from the AH1 subfamily as well as from AlkB enzymes linked to MTBE degradation in Mycobacterium austroafricanum.

  17. The prognostic role of {sup 99m}Tc-MDP breast scintigraphy. Comparison of scintigrafic findings with histologic and molecular parameters; Significato prognostico della scintigrafia mammaria con {sup 99m}Tc-MDP. Confronto con parametri istologici e molecolari

    Energy Technology Data Exchange (ETDEWEB)

    Dimonte, M. [Centro di Medicina Nucleare Calabrese, Lecce (Italy); Leo, G. [Azienda Ospedaliera V. Fazzi, Laboratorio Analisi, Lecce (Italy); Marsigliante, S. [Lecce Univ., Lecce (Italy). Dipt. di Biologia, Laboratorio di Fisiologia; Manca, C. [Azienda Ospedaliera V. Fazzi, Chirurgia Generale, Lecce (Italy)

    1999-11-01

    Breast scintigraphy (BS) with the bone-seeking agent {sup 99m}Tc-medronate (MDP) can be usefully combined with mammography to diagnose and characterize questionable breast lumps. However this radiotracer does not seem to provide any further prognostic information about breast cancer. Therefore it is investigated the prognostic yield of MDP-BS searching for correlations between scintigraphic findings and the major biological and histologic parameters. It is retrospectively analyzed a series of 44 primary breast cancers. All patients had undergone {sup 99m}Tc-MDP bone scan for preoperative staging, as well as conventional breast imaging. It is statistically compared the cancer/background ratio (c/b index) with lesion histotype, diameter, grading, and the tissue concentrations of steroid receptors, cathepsine D, type 1 timidine kinase, pS2 and p53 proteins. Differently from BS with {sup 99m}Tc-MIBI, {sup 201}Tl, {sup 18}F-FDG, {sup 111}In-OCT and radiolabeled estrogens and despite its good overall accuracy, MDP-BS appears to have no prognostic role. In fact, despite the well-known capability of soft tissue lesions to take up the tracer, MDP tumor trapping seems to depend mainly on the increased permeability of neo vessels and on interstitial space enlargement. Few reports are available in the literature on the correlation between in vivo MDP uptake by the breast cancer and prognostic parameters. Thus, it are tested possible correlations between the amount of MDP taken up by the breast cancer, histologic features and cell concentrations of some major biomarkers. The lack of any statistical significance is in agreement with the theory, and confirms the little prognostic value of MDP-BS. Nevertheless, further trials are warranted on larger series of cases to validate personal findings. [Italian] La scintigrafia mammaria (SM) con {sup 99m}Tc-medronato (MDP) sfrutta la ben nota capacita' di alcuni tumori extraossei di fissare tale radiofarmaco osteotropo. In

  18. Paucity of Nanolayering in Resin-Dentin Interfaces of MDP-based Adhesives.

    Science.gov (United States)

    Tian, F; Zhou, L; Zhang, Z; Niu, L; Zhang, L; Chen, C; Zhou, J; Yang, H; Wang, X; Fu, B; Huang, C; Pashley, D H; Tay, F R

    2016-04-01

    Self-assembled nanolayering structures have been reported in resin-dentin interfaces created by adhesives that contain 10-methacryloyloxydecyl dihydrogen phosphate (10-MDP). These structures have been hypothesized to contribute to bond durability. The objective of the present study was to determine the extent of nanolayering in resin-dentin interfaces after application of commercialized 10-MDP-containing self-etch and universal adhesives to human dentin. Seven commercialized adhesives were examined: Adhese Universal (Ivoclar-Vivadent), All-Bond Universal (Bisco, Inc.), Clearfil SE Bond 2, Clearfil S3 Bond Plus, Clearfil Universal Bond (all from Kuraray Noritake Dental Inc.), G-Premio Bond (GC Corp.), and Scotchbond Universal (3M ESPE). Each adhesive was applied in the self-etch mode on midcoronal dentin according to the respective manufacturer's instructions. Bonded specimens (n = 6) were covered with flowable resin composite, processed for transmission electron microscopy, and examined at 30 random sites without staining. Thin-film glancing angle X-ray diffraction (XRD) was used to detect the characteristic peaks exhibited by nanolayering (n = 4). The control consisted of 15%wt, 10%wt, and 5%wt 10-MDP (DM Healthcare Products, Inc.) dissolved in a mixed solvent (ethanol and water weight ratio 9:8, with photoinitiators). Experimental primers were applied to dentin for 20 s, covered with hydrophobic resin layer, and examined in the same manner. Profuse nanolayering with highly ordered periodicity (~3.7 nm wide) was observed adjacent to partially dissolved apatite crystallites in dentin treated with the 15% 10-MDP primer. Three peaks in the 2θ range of 2.40° (3.68 nm), 4.78° (1.85 nm), and 7.18° (1.23 nm) were identified from thin-film XRD. Reduction in the extent of nanolayering was observed in the 10% and 5% 10-MDP experimental primer-dentin interface along with lower intensity XRD peaks. Nanolayering and characteristic XRD peaks were rarely observed in

  19. Altered [99mTc]Tc-MDP biodistribution from neutron activation sourced 99Mo.

    Science.gov (United States)

    Demeter, Sandor; Szweda, Roman; Patterson, Judy; Grigoryan, Marine

    2018-01-01

    Given potential worldwide shortages of fission sourced 99 Mo/ 99m Tc medical isotopes there is increasing interest in alternate production strategies. A neutron activated 99 Mo source was utilized in a single center phase III open label study comparing 99m Tc, as 99m Tc Methylene Diphosphonate ([ 99m Tc]Tc-MDP), obtained from solvent generator separation of neutron activation produced 99 Mo, versus nuclear reactor produced 99 Mo (e.g., fission sourced) in oncology patients for which an [ 99m Tc]Tc-MDP bone scan would normally have been indicated. Despite the investigational [ 99m Tc]Tc-MDP passing all standard, and above standard of care, quality assurance tests, which would normally be sufficient to allow human administration, there was altered biodistribution which could lead to erroneous clinical interpretation. The cause of the altered biodistribution remains unknown and requires further research.

  20. A clinical compariosn of sup(99m)Tc-DPD and two sup(99m)Tc-MDP agents

    International Nuclear Information System (INIS)

    Vorne, M.; Vaehaetalo, S.; Lantto, T.

    1983-01-01

    Two hundred and fifty-seven patients were studied with bone-seeking radiopharmaceuticals. They were randomly divided into three groups. Two groups were injected with two different sup(99m)Tc-methylene diphosphonates from two manufactures (MDP 1 and MDP 2) and the third group with sup(99m)Tc-dicarboxypropane diphosphonate (DPD). DPD was found to be superior with respect to blood clearance, femur to soft tissue ratio and subjectivly assessed image quality. There seemed to be no marked differences between the bone-seeking agents in the visualisation of pathological foci. The image quality seemed to be better in the MDP 2 group than in the MDP 1 group but they were similar in other respects. The femur to soft tissue ratio decreased with increasing age in the DPD group but not in the MDP groups. With all agents worsening of scan quality with increasing age was noted and the image quality was better with men than with women. When short incubation times of radiopharmaceuticals were used before injection, the bone to soft tissue ratio was lower and the scan quality was poorer than with incubation times longer than 20 min. (orig.)

  1. The mycobacterial DNA-binding protein 1 (MDP1 from Mycobacterium bovis BCG influences various growth characteristics

    Directory of Open Access Journals (Sweden)

    Maurischat Sven

    2008-06-01

    Full Text Available Abstract Background Pathogenic mycobacteria such as M. tuberculosis, M. bovis or M. leprae are characterised by their extremely slow growth rate which plays an important role in mycobacterial virulence and eradication of the bacteria. Various limiting factors influence the generation time of mycobacteria, and the mycobacterial DNA-binding protein 1 (MDP1 has also been implicated in growth regulation. Our strategy to investigate the role of MDP1 in mycobacterial growth consisted in the generation and characterisation of a M. bovis BCG derivative expressing a MDP1-antisense gene. Results The expression rate of the MDP1 protein in the recombinant M. bovis BCG containing the MDP1-antisense plasmid was reduced by about 50% compared to the reference strain M. bovis BCG containing the empty vector. In comparison to this reference strain, the recombinant M. bovis BCG grew faster in broth culture and reached higher cell masses in stationary phase. Likewise its intracellular growth in mouse and human macrophages was ameliorated. Bacterial clumping in broth culture was reduced by the antisense plasmid. The antisense plasmid increased the susceptibility of the bacteria towards Ampicillin. 2-D protein gels of bacteria maintained under oxygen-poor conditions demonstrated a reduction in the number and the intensity of many protein spots in the antisense strain compared to the reference strain. Conclusion The MDP1 protein has a major impact on various growth characteristics of M. bovis BCG. It plays an important role in virulence-related traits such as aggregate formation and intracellular multiplication. Its impact on the protein expression in a low-oxygen atmosphere indicates a role in the adaptation to the hypoxic conditions present in the granuloma.

  2. Involvement of a Novel Enzyme, MdpA, in Methyl tert-Butyl Ether Degradation in Methylibium petroleiphilum PM1 ▿

    Science.gov (United States)

    Schmidt, Radomir; Battaglia, Vince; Scow, Kate; Kane, Staci; Hristova, Krassimira R.

    2008-01-01

    Methylibium petroleiphilum PM1 is a well-characterized environmental strain capable of complete metabolism of the fuel oxygenate methyl tert-butyl ether (MTBE). Using a molecular genetic system which we established to study MTBE metabolism by PM1, we demonstrated that the enzyme MdpA is involved in MTBE removal, based on insertional inactivation and complementation studies. MdpA is constitutively expressed at low levels but is strongly induced by MTBE. MdpA is also involved in the regulation of tert-butyl alcohol (TBA) removal under certain conditions but is not directly responsible for TBA degradation. Phylogenetic comparison of MdpA to related enzymes indicates close homology to the short-chain hydrolyzing alkane hydroxylases (AH1), a group that appears to be a distinct subfamily of the AHs. The unique, substrate-size-determining residue Thr59 distinguishes MdpA from the AH1 subfamily as well as from AlkB enzymes linked to MTBE degradation in Mycobacterium austroafricanum. PMID:18791002

  3. The prognostic role of 99mTc-MDP breast scintigraphy. Comparison of scintigrafic findings with histologic and molecular parameters

    International Nuclear Information System (INIS)

    Dimonte, M.; Leo, G.; Marsigliante, S.

    1999-01-01

    Breast scintigraphy (BS) with the bone-seeking agent 99m Tc-medronate (MDP) can be usefully combined with mammography to diagnose and characterize questionable breast lumps. However this radiotracer does not seem to provide any further prognostic information about breast cancer. Therefore it is investigated the prognostic yield of MDP-BS searching for correlations between scintigraphic findings and the major biological and histologic parameters. It is retrospectively analyzed a series of 44 primary breast cancers. All patients had undergone 99m Tc-MDP bone scan for preoperative staging, as well as conventional breast imaging. It is statistically compared the cancer/background ratio (c/b index) with lesion histotype, diameter, grading, and the tissue concentrations of steroid receptors, cathepsine D, type 1 timidine kinase, pS2 and p53 proteins). Differently from BS with 99m Tc-MIBI, 201 Tl, 18 F-FDG, 111 In-OCT and radiolabeled estrogens and despite its good overall accuracy, MDP-BS appears to have no prognostic role. In fact, despite the well-known capability of soft tissue lesions to take up the tracer, MDP tumor trapping seems to depend mainly on the increased permeability of neo vessels and on interstitial space enlargement. Few reports are available in the literature on the correlation between in vivo MDP uptake by the breast cancer and prognostic parameters. Thus, it are tested possible correlations between the amount of MDP taken up by the breast cancer, histologic features and cell concentrations of some major biomarkers. The lack of any statistical significance is in agreement with the theory, and confirms the little prognostic value of MDP-BS. Nevertheless, further trials are warranted on larger series of cases to validate personal findings [it

  4. Scintimammography with {sup 99m}Tc-MDP in the detection of primary breast cancer

    Energy Technology Data Exchange (ETDEWEB)

    Piccolo, S.; Lastoria, S.; Muto, P.; Bazzicalupo, L.; Bartiromo, A. [National Cancer Institute, Naples (Italy). Dept. of Nuclear Medicine; Salvatore, M. [CNR, Naples (Italy). Center for Nuclear Medicine

    1997-09-01

    Materials and methods. The diagnostic accuracy of scintimammography with {sup 99m}Tc-MDP was evaluated in 400 consecutive women with clinical or mammographic suspicion of breast cancer, candidate to surgery and/or excisional biopsy. Lateral views of both glands were acquired 5-10 min after the injection of 550-740 MBq of {sup 99m}Tc-MDP. The scintigraphic results were compared to mammograms and classified using the histological findings as gold standard. Results. Mammography was suggestive for cancer in 231 (57 %) suspicious in 49 (12 %) and indeterminate in 120 (31 %) patients. Breast carcinoma was histologically proven in 330 women, benign breast diseases in 70. The tumor size ranged from 4 x 5 to 50 x 60 mm. {sup 99m}Tc-MDP visualized as foci of increased uptake 305/330 cancers (92 %). In particular, in women with indeterminate mammograms the SMM had a diagnostic accuracy of 84 % correctly characterizing 101/120 lesions. Twenty missed cancers had largest diameter {<=} 10 mm, 5 {<=} 15 mm. Lack of {sup 99m}Tc-MDP uptake occurred in 64 out of 70 benign lesions. These lesions were classified as truly negative. Conversely, 3 fibroadenoma and 3 epithelial hyperplasia with moderate or severe atypia were falsely positive. The overall specificity was 91.5 %; the accuracy was 92 % the positive and negative predictive values were respectively 98 % and 72 %. Conclusions. The results obtained in this study suggest that {sup 99m}Tc-MDP scintimammography accurately detects breast carcinomas with largest diameter > 10 mm; it differentiates malignant from benign lesions, and it shows promising insights in characterizing breast abnormalities mammographically indeterminate.

  5. Labeling of MDP with {sup 188}Re for bone tumour therapy

    Energy Technology Data Exchange (ETDEWEB)

    Barbezan, Angelica B.; Osso Junior, Joao A., E-mail: jaosso@ipen.b [Instituto de Pesquisas Energeticas e Nucleares (IPEN/CNEN-SP), Sao Paulo, SP (Brazil)

    2011-07-01

    {sup 188}Re is one of the most attractive radioisotopes for a variety of therapeutic applications in nuclear medicine, due to its physical decay properties, such as {beta}{sup -} emission of 2.12 MeV, {gamma} emission of 155 keV and half life of 16.9 hours. Biphosphonates are potent inhibitors of osteoclastic bone resorption and are effective in several diseases that cause bone fragility and bone metastases. Because of these characteristics, labeled biphosphonates have been studied for bone pathologies, also acting as palliation of bone pain in case of metastasis.The aim of this study was to optimize the labeling of a phosphonate-MDP (Sodium Methylene Diphosphonate) with {sup 188}Re for use in bone pain palliation. {sup 188}Re was obtained by eluting a {sup 188}W-{sup 188}Re generator from POLATOM. The labeling was performed at room temperature using MDP, SnCl{sub 2} as reducing agent and ascorbic acid. The variables studied were: Mass of ligand (3, 6 and 10 mg), reducing agent mass (5, 7, 10 and 11 mg), ascorbic acid mass (1, 3, 5 and 6 mg), pH (1 and 2) and time of reaction (15, 60, 120, 360 and 4320 minutes), that also reflected the stability of the radiopharmaceutical. The radiochemical control, that also measures the labeling efficiency was evaluated by paper chromatography using Whatman 3MM paper and the solvents acetone and 0.9%NaCl. The best formulation was the following: Mass of ligand MDP: 10 mg, mass of SnCl{sub 2}: 5 mg, ascorbic acid mass: 3 mg, time of reaction: 30 minutes, pH: 1. Under optimum conditions, {sup 188}Re MDP radiolabeling yield was 98,07% and the radiopharmaceutical was stable up to 72 h. (author)

  6. Effect of a functional monomer (MDP) on the enamel bond durability of single-step self-etch adhesives.

    Science.gov (United States)

    Tsuchiya, Kenji; Takamizawa, Toshiki; Barkmeier, Wayne W; Tsubota, Keishi; Tsujimoto, Akimasa; Berry, Thomas P; Erickson, Robert L; Latta, Mark A; Miyazaki, Masashi

    2016-02-01

    The present study aimed to determine the effect of the functional monomer, 10-methacryloxydecyl dihydrogen phosphate (MDP), on the enamel bond durability of single-step self-etch adhesives through integrating fatigue testing and long-term water storage. An MDP-containing self-etch adhesive, Clearfil Bond SE ONE (SE), and an experimental adhesive, MDP-free (MF), which comprised the same ingredients as SE apart from MDP, were used. Shear bond strength (SBS) and shear fatigue strength (SFS) were measured with or without phosphoric acid pre-etching. The specimens were stored in distilled water for 24 h, 6 months, or 1 yr. Although similar SBS and SFS values were obtained for SE with pre-etching and for MF after 24 h of storage in distilled water, SE with pre-etching showed higher SBS and SFS values than MF after storage in water for 6 months or 1 yr. Regardless of the pre-etching procedure, SE showed higher SBS and SFS values after 6 months of storage in distilled water than after 24 h or 1 yr. To conclude, MDP might play an important role in enhancing not only bond strength but also bond durability with respect to repeated subcritical loading after long-term water storage. © 2015 Eur J Oral Sci.

  7. Biokinetics of osteotropic radiopharmaceuticals in metabolic osteopathies - comparison of /sup 47/Ca and sup(99m)Tc-MDP

    Energy Technology Data Exchange (ETDEWEB)

    Knop, J.; Montz, R.

    1983-10-01

    Plasma clearance and osseous accumulation rates of sup(99m)Tc methylene diphosphonate (MDP) in the lumbar spine were measured in 11 patients with osteoporosis (OP), 7 patients with hyperparathyroidism (HPT), 4 patients with osteomalacia (OM) and in 3 patients (N) who were studied to exclude metabolic bone disease. The findings in 19 patients were compared with the results of /sup 47/Ca kinetics. The plasma elimination of sup(99m)Tc-MDP during the first hour after application was normal in almost all the patients. The sup(99m)Tc-MDP accumulation rates in the lumbar spine were raised in patients with HPT and OM (p<=0,01) and normal in patients with OP and N (p>0,05). /sup 47/Ca kinetics were disturbed in most of the patients with metabolic bone disease, with minimal deviations in OP. The comparison of sup(99m)Tc-MDP accumulation rates with the results of /sup 47/Ca kinetics revealed significant correlations with exchangeable bone and soft tissue calcium. The correlations with total calcium turnover and calcium accretion were poor. Only half of the patients had equal results of sup(99m)Tc-MDP accumulation rates and bone calcium accretion rates. It is concluded that the sup(99m)Tc-MDP uptake by bone is an index of bone metabolism presumably of the organic matrix, whereas /sup 47/Ca kinetics represent the mineral metabolism of bone.

  8. Therapeutic application of 99Tc-MDP in advanced nodose rheumatoid patients with multiple arthrosis erosion and malfunctioning

    International Nuclear Information System (INIS)

    Yuan Jiming

    2001-01-01

    Objective: To evaluate clinical effect of 99 Tc-MDP in treating arthrosis erosion in advanced nodose rheumatism. Methods: Therapy was performed undisrupted for 1 to 2 years in each patient at a high dose of 1.0-1.5 g/month. Results: After more than 1 year's 99 Tc-MDP therapy, 10 patients with multiple arthrosis erosion and serious malfunctioning had function recovery and arthral reformation of different extent. Patients with obvious therapeutic effects were able to walk, travel and completely or partially took care of themselves. Cortisone was prohibited or permitted at a lower dose of 1.25 mg/day in 3 patients who were dependant on prednisone. As results from 99 Tc-MDP therapy, X-ray photography revealed broadened arthral gap, reformation of previously eroded arthrosis and even improvement in osteoporosis. Conclusion: Reversible changes resulted from 99 Tc-MDP therapy showed breakthrough in treatment of advanced nodose rheumatism and serious ostearthritis, whose pathological changes were previously considered irreversible

  9. Comparison of 99m-Tc-MDP and 99m-Tc-MIBI whole body scans for diagnosis of widespread skeletal metastases

    International Nuclear Information System (INIS)

    Ansari, M.; Hoshiar, A.; Mortazavi, S.H.

    2002-01-01

    Skeletal metastasis is one of the most important disabling complications of the malignant diseases. As in general, the survival of patients with osteometastatic lesions is relatively long, an early diagnosis can lead to improve the patient's life, both quantitatively and qualitatively and prevent exacerbation of the disease and disabling complications. In this study 22 patients with established diagnosis of malignant disease and clinical manifestations of skeletal metastasis were evaluated both with 99 m-Tc-MIBI and 99 m-Tc-MDP whole body scans, in two separate phases. Patient's diagnosis were as following: small round cell tumor, breast carcinoma. Nasopharynx carcinoma and multiple myeloma. In the first phase of the study a whole body bone scan was performed by IV injection of 740MBq 99 m-Tc-MDP. After a period of 1 week a whole body scan carried out by 99 m-Tc-MDP for all the patients. No treatment such as radiation therapy ar chemotherapy was done in this 1 week interval. The number and intensity of the scan findings were compared visually, according to the three- phase staging, subsequently. whole body survey with 99 m-Tc-MDP in 14 out 22 patient were positive demonstrating only 44.4% of body lesions established on whole body bone scan with 99 m-Tc-MDP. The mean value of intensity of radiotracer uptake was around 1.5+ (mild to moderate ). on the other hand in 7 patients with positive 99 m-Tc-MDP scan some hidden soft tissue lesions ( mostly lymph nodes) were detected with intensity of 2+. So this study shows that whole body bone scan is preferable for detection of widespread metastasis comparing with 99 m-Tc-MDP whole body scan. the significance of 99 m-Tc-MDP scan is mainly limited to some equivocal of soft tissue lesions

  10. The effect of continuous application of MDP-containing primer and luting resin cement on bond strength to tribochemical silica-coated Y-TZP.

    Science.gov (United States)

    Lim, Myung-Jin; Yu, Mi-Kyung; Lee, Kwang-Won

    2018-05-01

    This study investigated the effect of continuous application of 10-methacryloyloxydecyldihydrogen phosphate (MDP)-containing primer and luting resin cement on bond strength to tribochemical silica-coated yttria-stabilized tetragonal zirconia polycrystal (Y-TZP). Forty bovine teeth and Y-TZP specimens were prepared. The dentin specimens were embedded in molds, with one side of the dentin exposed for cementation with the zirconia specimen. The Y-TZP specimen was prepared in the form of a cylinder with a diameter of 3 mm and a height of 10 mm. The bonding surface of the Y-TZP specimen was sandblasted with silica-coated aluminium oxide particles. The forty tribochemical silica-coated Y-TZP specimens were cemented to the bovine dentin (4 groups; n = 10) with either an MDP-free primer or an MDP-containing primer and either an MDP-free resin cement or an MDP-containing resin cement. After a shear bond strength (SBS) test, the data were analyzed using 1-way analysis of variance and the Tukey test (α = 0.05). The group with MDP-free primer and resin cement showed significantly lower SBS values than the MDP-containing groups ( p Y-TZP was the best choice among the alternatives tested in this study.

  11. Age-related normal uptake of 99mTc-MDP in the lower spine

    International Nuclear Information System (INIS)

    Sundkvist, G.M.G.; Lilja, B.; Mattsson, S.

    1997-01-01

    Aim: The uptake of 99m Tc-MDP in the lower spine was quantified in connection with ordinary bone scintigraphy. Methods: Fifty-seven women and seventy-two men (aged 20-69 y), with no signs of metabolic or malignant disease and no history of back pain or atraumatic fractures, were included in the study. Results: The women showed an increase in 99m Tc-MDP uptake from the age of 20 y to about 45 y with a decrease from the time of menopause. In contrast to women, the uptake in men showed a slight decrease from the age of 20 y to about 50 y and thereafter a more marked decrease was seen. The major difference between men and women is the high premenopausal uptake in the female skeleton. Conclusion: An understanding of age-related changes in 99m Tc-MDP uptake, which are indices of the skeletal metabolism, is of importance especially in prevention and treatment of osteoporosis, a common disorder in postmenopausal women. (orig.) [de

  12. Abnormal gastrointestinal accumulation of radiotracer by gastric bleeding during 99mTc-MDP bone scintigraphy

    International Nuclear Information System (INIS)

    Chun, Kyung A.; Lee, Sang Woo; Lee, Jae Tae; Lee, Kyu Bo

    1998-01-01

    We present a case in which a patient with acute hemorrhagic gastritis demonstrated abnormal gastrointestinal accumulation of radiotracer during 99m Tc-methylene diphosphonate (MDP) skeletal scintigraphy. A hemorrhagic gastritis was subsequently demonstrated by endoscopy. The mechanism for the intestinal localization of 99m Tc-MDP in this patients is not clear, but we guess that the extravasated blood containing the radiopharmaceutical cannot recirculate and stays at the bleeding site, so we can see the intestinal activity

  13. Differentiation of malignant and degenerative benign bone disease using Tc-99m Citrate and Tc-99m MDP scintigraphy

    International Nuclear Information System (INIS)

    Jin, J.; Guo, R.; Li, S.-J.; Ren, Y.; Zhang, C.; Zhang, X.

    2007-01-01

    Full text: For the evaluation of bone metastases in patients (pts) with cancer, 99mTcMDP bone scintigraphy is an important tool, but some limitations exist. One of these is the differential diagnosis of malignant and degenerative benign bone disease. The aim of this study was to differentiate them using 99mTcCitrate and 99mTcMDP scintigraphy. Methods: 39 pts (92 lesions) with known malignant or degenerative benign bone disease were studied. 23 pts had malignant bone disease (48 lesions, group 1), the other 16 pts had degenerative benign bone disease (44 lesions, group2), for which the results of 99mTcMDP scintigraphy were positive. In both groups, 99mTcCitrate scintigraphy was performed within a time interval of 2-7 days after 99mTcMDP scintigraphy (555∼740MBq. static, 3hr, planar or SPECT i m a g e s w h e n r e q u i r e d ) . The 99mTccitrate/99mTcMDP lesion-to-background radioisotope uptake ratio (RUR) was calculated for each lesion. Conventional techniques (histopathology, X-ray, CT, MRI and clinical follow up) were considered to be proof of the presence of bone metastases and degenerative benign bone disease. Results: Uptake of 99mTcMDP in the two groups is the same (1.96±0.25 vs. 1.87±0.21; t=1.178, P>0.20), while in 99mTcCitrate image, malignant lesions demonstrated a higher uptake of lesion activity than that of benign degenerative lesions (1.47±0.42 vs. 1.09±0.38; t=2.887, P<0.01). The mean 99mTccitrate/99mTcMDP RUR in the malignant group was significantly higher than the mean in the benign group (0.78±0.21 vs. 0.54±0.19; t=3.646, P<0.001). Conclusions: The preliminary results of the study confirm the usefulness and feasibility of 99mTcCitrate scintigraphy for differentiating malignant from benign degenerative lesions seen as areas of increased activity on 99mTcMDP bone scintigraphy. (author)

  14. The MDP skull uptake test: A new diagnostic tool

    International Nuclear Information System (INIS)

    Ell, P.J.; Jarritt, P.H.; Cullum, I.; Lui, D.

    1984-01-01

    An original approach to the measurement of bone turnover is presented. With SPECT, the authors have measured in pgr/ml, the uptake of MDP by the skull in man. The Cleon 710 scanner, ring phantoms and bone biopsies were used for ultimate in vivo/in vitro count recovery correlation and calibration. A normal range for 24 patients was found: 8.5 to 19.5 pgr/ml with a mean of 14. For patients with bony metastases (12), the values were: 22.5 to 50, mean of 30. For 5 patients with osteomalacia, the values were 46 to 68, mean of 62: for 12 patients with hyperparathyroidism, the values were 37 to 48.5, mean of 43. In 3 patients with Pagets disease, the values were 58.5 to 75, with a mean of 65. In 76 patients with metastatic disease to bone, the conventional wholebody bone scan was investigated against the following: 24h wholebody retention of MDP (WBR), skull uptake as described and GFR by Cr-51-DTPA. There is a correlation between GFR and WBR - r=0.67. There is a lesser correlation between GFR and skull uptake - r=0.3. There is no correlation between skull uptake and WBR - r=0.1. The comparison of skull uptake data with normal whole body bone scans leads to a significant proportion of cancer patients with positive skull uptake data. Monostotic disease (especially if metabolic in nature) expresses itself by abnormal skull uptake even if the clinical site of abnormality lies outside the skull. This new technique is ideal as a tool to investigate phosphonate concentration in bone. With it, the authors have shown the effect of specific activity of label on skull uptake, which increases as the specific activity of labelled MDP decreases

  15. A refined method for assessing sup(99m)Tc-MDP whole body retention in prostate cancer patients

    International Nuclear Information System (INIS)

    Castronovo, F.P. Jr.; Strauss, H.W.; McKusick, K.A.

    1987-01-01

    Whole body retention (WBR) of sup(99m)Tc labeled methylene diphosphonate (MDP) significantly differentiates various clinical stages of prostate cancer. Whole body measurements, when performed at 5 min and 24 h after i.v. administration of sup(99m)Tc-MDP, allows for the calculations of percentage whole body retention (% WBR) after one day. In an attempt to better describe the clinical course of prostate cancer patients with bone metastases we have refined the % WBR calculations to include a normalization factor. The latter consists of the mean 24-h value of WBR's as obtained from 10 prostate cancer patients without bony metastases as determined by bone scintigram. The % WBR is then divided by the normalization factor of choice and expressed as (% WRN)sup(N). These data are used to better express sup(99m)Tc MDP 24-h whole body retentions when following the clinical course of patients with metastatic carcinoma of the prostate. Caution should be exercised when interpreting these data when metabolic bone pathology is present. A false negative (% WBR)sup(N) value will result if an infiltration of the sup(99m)Tc-MDP occurs during administration. (author)

  16. Abnormal gastrointestinal accumulation of radiotracer by gastric bleeding during {sup 99m}Tc-MDP bone scintigraphy

    Energy Technology Data Exchange (ETDEWEB)

    Chun, Kyung A.; Lee, Sang Woo; Lee, Jae Tae; Lee, Kyu Bo [College of Medicine, Kyungpook National Univ., Taegu (Korea, Republic of)

    1998-06-01

    We present a case in which a patient with acute hemorrhagic gastritis demonstrated abnormal gastrointestinal accumulation of radiotracer during {sup 99m}Tc-methylene diphosphonate (MDP) skeletal scintigraphy. A hemorrhagic gastritis was subsequently demonstrated by endoscopy. The mechanism for the intestinal localization of {sup 99m}Tc-MDP in this patients is not clear, but we guess that the extravasated blood containing the radiopharmaceutical cannot recirculate and stays at the bleeding site, so we can see the intestinal activity.

  17. Tc-99m-MDP/Ga-67 SPECT in the evaluation of otitis externa

    International Nuclear Information System (INIS)

    Tumeh, S.S.; Hamdan, U.; Desisto, W.; English, R.J.

    1988-01-01

    Four patients with otitis externa were studied with Tc-99m MDP and Ga-67 single photon emission computed tomography (SPECT). In addition to the abnormal uptake in the external ear seen with planar imaging, SPECT demonstrated mastoid uptake (proved clinically) that was not appreciated with planar imaging in three patients, one of whom had negative x-ray computed tomographic (CT) findings. In one patient, SPECT demonstrated midline uptake in the skull base that was not depicted by x-ray CF.No false-positive results were seen. The authors conclude that Tc-99m MDP/Ga-67 SPECT is superior to planar imaging and should be used in the evaluation of otitis externa

  18. Experimental studies on the accumulation of 99mTc-MDP in the bupivacaine hydrochloride induced myopathy

    International Nuclear Information System (INIS)

    Sone, Shinsuke

    1989-01-01

    It has recently been demonstrated that several 99m Tc-labeled phosphate compounds accumulate in skeletal muscle in patients with myopathies including Duchenne muscular dystrophy (DMD). However, the mechanism by which these compounds accumulate in skeletal muscles is unknown. In order to analyze the mechanisms of tracer-localization in skeletal muscles of myopathies, the uptake of 99m Tc-methylendiphosphonate ( 99m Tc-MDP) by muscles examined in rats treated by intramuscular injection of a local anesthetic, bupivacaine. At the same time, the histological and biochemical changes of the injured muscles were studied, and findings obtained were correlated with the procedure of 99m Tc-MDP uptake. Intramuscular injection of bupivacaine resulted in markedly increased uptake of 99m Tc-MDP in the injected muscle at 12 and 24 hours after injection. The plasma creatine phosphokinase (CK) concentration increased 2-3 folds during the period from 3 to 24 hours after bupivacaine injection. Four days following injection, the CK isozyme MB activity in muscle increased. Twenty hours after injection of bupivacaine, changes such as hypercontraction and disruptin of myofibrils, Z-band lysis, and swelling of mitochondria occurred. Four days after the injection, myoblasts and myotubes were found in the damaged areas of the muscle. These results show that the increased muscle uptake of 99m Tc-MDP reflects the early degenerative changes of skeletal muscle. (author)

  19. Technetium-99 conjugated with methylene diphosphonate (99Tc-MDP) inhibits experimental choroidal neovascularization in vivo and VEGF-induced cell migration and tube formation in vitro.

    Science.gov (United States)

    Lai, Kunbei; Xu, Li; Jin, Chenjin; Wu, Kaili; Tian, Zhen; Huang, Chuangxin; Zhong, Xiaojing; Ye, Haiyun

    2011-07-29

    To investigate the effects of (99)Tc-MDP, a decay product of (99m)Tc-MDP, on the development of choroidal neovascularization (CNV), together with its underlying mechanisms. C57BL/6J mice were used to induce CNV by laser photocoagulation. (99)Tc-MDP at the doses of 0.5 × 10(-1), 1 × 10(-1), and 2 × 10(-1) μg/kg or the same volume of PBS was intraperitoneally injected daily after photocoagulation until the end of the experiment. Seven days after laser injury, mice were perfused with fluorescein-labeled dextran, and areas of CNV were measured. Numbers of infiltrating macrophages, protein levels of VEGF, and inflammation-related molecules including intercellular adhesion molecule (ICAM)-1, tumor necrosis factor (TNF)-α, and matrix metalloproteinases (MMPs) in the RPE-choroid complex were detected 3 days after laser photocoagulation. Effects of (99)Tc-MDP on VEGF-induced endothelial cell migration and tube formation were also studied. Toxicity of (99)Tc-MDP was evaluated in vivo and in vitro. Areas of CNV were significantly suppressed by (99)Tc-MDP treatment without toxicity to the retina compared with PBS treatment in a dose-dependent manner: (99)Tc-MDP treatment of 0.5 × 10(-1) μg/kg (5698.60 ± 1037.70 μm(2)), 1 × 10(-1) μg/kg (3678.34 ± 1328.18 μm(2)), and 2 × 10(-1) μg/kg (2365.78 ± 923.80 μm(2)) suppressed the development of CNV by 36.12%, 58.76%, and 73.48%, respectively, compared with that in the PBS treatment group (8920.36 ± 1097.29 μm(2); P 99)Tc-MDP treatment led to significant inhibition of macrophages infiltrating to CNV together with downregulated protein expressions of VEGF, ICAM-1, TNF-α, and MMP-2. (99)Tc-MDP also showed an inhibitive effect on cell proliferation and VEGF-induced migration and capillary-like tube formation of endothelial cells. Anti-inflammatory treatment with (99)Tc-MDP has therapeutic potential for CNV-related diseases.

  20. The rate of 99m Tc-MDP uptake in metastatic bone lesions before and after 89m Sr therapy

    International Nuclear Information System (INIS)

    Souza, Joseane Fonseca; Braga, Francisco J.H.N.

    1996-01-01

    The rate of 99m Tc-MDP uptake is studied in metastatic bone lesions, before and after 89m Sr therapy. Eight hopeless patients (age between 56 and 74) presenting disseminated carcinoma of the prostate are evaluated. No hormonal therapy and a limited radiotherapy were considered. It is concluded that therapeutical doses of 89m Sr reduces MDP uptake

  1. Comparative uptake of 67Ga and /sup 99m/Tc MDP in rabbits with a benign noninfected bone lesion (fracture)

    International Nuclear Information System (INIS)

    Bushberg, J.T.; Hoffer, P.B.; Schreiber, G.J.; Lawson, A.J.; Lawson, J.P.; Lord, P.

    1985-01-01

    Mid-shaft fractures of the radius and ulna were produced in 3 to 4 kg New Zealand white rabbits and quantitative uptake of /sup 99m/Tc MDP and 67 Ga determined at 11, 18, 25, 32, 51, and 78 days following fracture. Two hundred microCi of 67 Ga was administered 24 hours prior to sacrifice and 1.5 mCi /sup 99m/Tc MDP 2 hours prior to sacrifice. Specific activity ratios (SARs) were determined between fracture and control sides for bone, muscle and skin. SARs for bone were surprisingly similar for /sup 99m/Tc MDP and 67 Ga, reaching peak values of 6.07 +/- 0.64 (/sup 99m/Tc 18 days); 6.58 +/- 0.90 ( 67 Ga 32 days), subsequently decreasing to minimum values at 78 days postfracture (/sup 99m/Tc MDP 2.25 +/- 0.14; 67 Ga 2.18 +/- 0.08). There was no statistically significant difference in SAR for /sup 99m/Tc MDP vs. 67 Ga in bone at any time after fracture. Whole sections of limb were resected on selected animals and activity ratios determined for these sections as a function of the contribution of activity from the various tissues in the volume of interest. Total activity ratios of 67 Ga were lower than bone SARs as a result of the contribution of activity from muscle and skin. Thus, the apparent lower activity ratios noted on 67 Ga images compared with /sup 99m/Tc MDP images in this fracture model were not due to differences in bone SARs but rather due to the higher soft tissue background activity contribution in the 67 Ga images

  2. Effects of 99Tc-MDP on synoviocytes and articular chondrocytes apoptosis associated factors on CIA rats

    International Nuclear Information System (INIS)

    Hu Shaoxian; Kong Fang; Ke Dan; Shu Min; Len Xiaomei; Tu Wei; Shen Guifen; He Peigen

    2009-01-01

    Objective: Collagen induced arthritis (CIA) rats is an animal model of human rheumatoid arthritis (RA). It is widely used in research of the pathogenesis and the therapeutic targets of RA. This paper was to investigate the therapeutic action of 99 Tc-methylene diphosphonic acid (MDP) on CIA rats and its effects on the expression of apoptosis associated factor bcl-2 and bax in synoviocytes and articular chondrocytes. Methods: CIA rat models were carried out by subcutaneous injection with bovine collagen II and incomplete Freud's adjuvant. Rats were divided into four groups: control group, CIA model group (the CIA rats were infused with physiological saline via tail vein daily), 99 Tc-MDP group (the C1A rats were injected with 99 Tc-Mi)P 0.04 μg 99 Tc/kg via tail vein daily) and methotrexate (MTX) group (the CIA rats were injected with MTX 1 mg/kg via tail vein weekly). The signs of arthritis were evaluated by arthritis index (AI) scores. Immunohistochemistry was performed to detect the expression of bcl-2 and bax in synoviocytes and articular chondrocytes. SPSS 13.0 was used for data analysis. Results: (1) The signs of arthritis, AI scores and pathological changes of arthrosynovitis in CIA rats were significantly improved by 99 Tc-MDP or MTX. (2) The expression of bcl-2 and box in the synoviocytes of CIA model group [(39.30 ± 0.53) %, (27.37 ± 2.45)%] was significantly increased compared with control group [(7.56 ± 1. 18)% , (6.14 ± 1.71) % ; q = 46.27, 24.57, all P 99 Tc-M DP group and MTX group, the level of bcl-2 was remarkably decreased [(30.24 ± 2.09) %, (27.25 ± 3.33) %] compared with CIA model group (q = 13.20, 17.56, all P 99 Tc-MDP group [(26. 58 ± 2. 52) %] and MTX group [(27.06 ± 1.92) %] was remarksbly increased [(24.26 ± 2.75) %, (23.53 ± 0.74) % ; q = 6.53, 7.01, all P 99 Tc-MDP could improve the signs of arthritis, meanwhile regulate the expression of bcl-2 and bax in synoviocytes and articular ehondrocytes, suggesting that one of the

  3. 99Tcm-MDP imaging for the diagnosis of joint infection after total hip arthroplasty

    International Nuclear Information System (INIS)

    Li Yuan; Wang Qian; Yue Minggang

    2013-01-01

    Objective: To investigate the value of 99 Tc m -MDP imaging for the differential diagnosis between infection and aseptic loosening after total hip arthroplasty. Methods: During February 2008 to August 2011, 74 patients (32 males, 42 females, average age (64.3±11.2) years) with hip pain after arthroplasty underwent 3-phase (blood flow, blood pool and bone phases) 99 Tc m -MDP imaging. All patients had measurements of serum C reactive protein (CRP) and erythrocyte sedimentation rate (ESR). Joint infection was defined as either increased peri-prosthetic soft tissue activity during perfusion and blood pool phases or increased peri-prosthetic bone activity during uptake phase, or positive in all 3 phases. Aseptic loosening was defined as having negative 99 Tc m -MDP in all 3 phases. Clinical diagnosis was chosen as the gold standard. The blood flow-pool imaging was compared with the serum examinations. χ 2 test was used for statistical analysis. Results: There were 74 symptomatic joints in 74 patients, including 24 joint infections and 50 aseptic loosening. For the detection of peri-prosthetic infection, combined perfusion-blood-pool phase was more accurate than bone uptake phase (90.5% (67/74) vs 55.4% (41/74); χ 2 =23.159, P<0.001), with the sensitivity of 91.7% (22/24) vs 70.8% (17/24) and specificity of 90.0% (45/50) vs 48.0% (24/50), respectively. The blood flow-pool imaging was also more accurate than CRP (73.0% (54/74); χ 2 =7.656, P<0.05) and ESR (71.6% (53/74); χ 2 =8.633, P<0.05), respectively. Conclusion: 99 Tc m -MDP perfusion/blood flow-pool imaging is an accurate modality for differentiating peri-prosthetic infection from aseptic loosening in patients with hip pain after arthroplasty. (authors)

  4. Experimental studies on the accumulation of /sup 99m/Tc-MDP in the bupivacaine hydrochloride induced myopathy

    Energy Technology Data Exchange (ETDEWEB)

    Sone, Shinsuke

    1989-02-01

    It has recently been demonstrated that several /sup 99m/Tc-labeled phosphate compounds accumulate in skeletal muscle in patients with myopathies including Duchenne muscular dystrophy (DMD). However, the mechanism by which these compounds accumulate in skeletal muscles is unknown. In order to analyze the mechanisms of tracer-localization in skeletal muscles of myopathies, the uptake of /sup 99m/Tc-methylendiphosphonate (/sup 99m/Tc-MDP) by muscles examined in rats treated by intramuscular injection of a local anesthetic, bupivacaine. At the same time, the histological and biochemical changes of the injured muscles were studied, and findings obtained were correlated with the procedure of /sup 99m/Tc-MDP uptake. Intramuscular injection of bupivacaine resulted in markedly increased uptake of /sup 99m/Tc-MDP in the injected muscle at 12 and 24 hours after injection. The plasma creatine phosphokinase (CK) concentration increased 2-3 folds during the period from 3 to 24 hours after bupivacaine injection. Four days following injection, the CK isozyme MB activity in muscle increased. Twenty hours after injection of bupivacaine, changes such as hypercontraction and disruptin of myofibrils, Z-band lysis, and swelling of mitochondria occurred. Four days after the injection, myoblasts and myotubes were found in the damaged areas of the muscle. These results show that the increased muscle uptake of /sup 99m/Tc-MDP reflects the early degenerative changes of skeletal muscle.

  5. Measurement of 24-hr whole-body retention of sup(99m)Tc-MDP with a thyroid uptake probe

    International Nuclear Information System (INIS)

    Seto, Hikaru; Kakishita, Masao; Futatsuya, Ryusuke

    1981-01-01

    A new method for measurement of 24-hr whole-body retention (WBR) of sup(99m)Tc-MDP, using a thyroid uptake probe was established and its clinical significance was evaluated in various bone diseases. (1) Reproducibility of 24-hr WBR in 9 patients was very good. Correlation coefficient was 0.997 and coefficient of variability was only 1.83%. (2) Radiochemical purity of sup(99m)Tc-MDP was 97.8 +- 0.7% (n = 5), indicating no significant inter-lot variations. (3) 24-hr WBR of normal adult males (n = 5) was 30.0 +- 4.9%, which was significantly elevated compared to the reported sup(99m)Tc-HEDP WBR of 19.2 +- 1.7%. Whole-body retentions of chronic renal failure, metastatic bone disease and hyperthyroidism groups were significantly elevated compared to that of the normal group. However, WBR of steroid-induced osteoporotic group was significantly decreased. Based on these results, this thyroid uptake probe method was simple, reproducible and accurate to measure 24-hr WBR of sup(99m)Tc-MDP. Quantification of WBR of sup(99m)Tc-MDP was of great clinical value to diagnose metabolic bone disease and to follow-up metabolic and metastatic bone diseases. (author)

  6. sup(99m)Tc-MDP scintigraphy for the detection and localization of rhabdomyolysis

    International Nuclear Information System (INIS)

    Schicha, H.; Rumpf, K.W.; Kaiser, H.; Emrich, D.; Goettingen Univ.

    1984-01-01

    In 24 patients with biochemically proven rhabdomyolysis 34 scans with sup(99m)Tc-MDP were performed to detect regional as well as generalized myolysis. When performing the scan within 10 days after the maximum of myolysis, scintigraphic detection was possible in 95% of the patients, but after 20 days in none. Regional tracer accumulation in muscles was more frequent (89%) than generalized diffuse accumulation (31%). Predominantly muscles of the thigh, the buttocks and the upper arm were involved. Diffuse tracer accumulation in both kidneys occurred in 75% of patients with significant renal dysfunction. The results show that in addition to regional muscle damage generalized myolysis may be detected by scintigraphy with sup(99m)Tc-MDP. In cases of regional muscle damage scintigraphy proved to be more sensitive than clinical signs. (orig.) [de

  7. sup(99m)Tc-MDP scintigraphy for the detection and localization of rhabdomyolysis

    Energy Technology Data Exchange (ETDEWEB)

    Schicha, H.; Rumpf, K.W.; Kaiser, H.; Emrich, D.

    1984-12-01

    In 24 patients with biochemically proven rhabdomyolysis 34 scans with sup(99m)Tc-MDP were performed to detect regional as well as generalized myolysis. When performing the scan within 10 days after the maximum of myolysis, scintigraphic detection was possible in 95% of the patients, but after 20 days in none. Regional tracer accumulation in muscles was more frequent (89%) than generalized diffuse accumulation (31%). Predominantly muscles of the thigh, the buttocks and the upper arm were involved. Diffuse tracer accumulation in both kidneys occurred in 75% of patients with significant renal dysfunction. The results show that in addition to regional muscle damage generalized myolysis may be detected by scintigraphy with sup(99m)Tc-MDP. In cases of regional muscle damage scintigraphy proved to be more sensitive than clinical signs.

  8. Marginal gap, cement thickness, and microleakage of 2 zirconia crown systems luted with glass ionomer and MDP-based cements.

    Science.gov (United States)

    Sener, Isil; Turker, Begum; Valandro, Luiz Felipe; Ozcan, Mutlu

    2014-01-01

    This in vitro study evaluated the marginal gap, cement thickness, and microleakage of glass-ionomer cement (GIC) and phosphate monomer-containing resin cement (MDP-RC) under 2 zirconia crown systems (Cercon and DC-Zirkon). Forty human premolars were prepared for all-ceramic zirconia crowns with a 1 mm circumferential finish line and a 1.5 mm occlusal reduction. The crowns (n = 10 per group) from each zirconia system were randomly divided into 2 groups and cemented either with GIC (Vivaglass CEM) or MDP-RC (Panavia F 2.0) cement. The cemented crowns were thermocycled 5000 times (5°-55°C). The crowns were immersed in 0.5% basic fuchsine dye solution for 24 hours and sectioned buccolingually and mesiodistally. Specimens were examined under optical microscope (100X). Data were analyzed using Student t-test and chi-square tests (α = 0.05). Mean marginal gap values for Cercon (85 ± 11.4 μm) were significantly higher than for DC-Zircon (75.3 ± 13.2 μm) (P = 0.018). The mean cement thickness values of GIC (81.7 ± 13.9 μm) and MDP-RC (78.5 ± 12.5 μm) were not significantly different (P = 0.447). Microleakage scores did not demonstrate significant difference between GIC (P = 0.385) and MDP-RC (P = 0.631) under Cercon or DC-Zircon. Considering the cement thickness values and microleakage scores obtained, both zirconia crown systems could be cemented in combination with either GIC or MDP-RC.

  9. Chromium 51 EDTA/technetium 99m MDP plasma ratio to measure total skeletal function

    Energy Technology Data Exchange (ETDEWEB)

    Nisbet, A.P.; Edwards, S.; Lazarus, C.R.; Malamitsi, J.; Maisey, M.N.; Mashiter, G.D.; Winn, P.J. (Guy' s Hospital, London (UK))

    1984-08-01

    A method is described for the quantitation of total skeletal activity during bone scans. The method requires a single plasma sample only, taken at the time of imaging. The ratio of % injected dose of /sup 51/Cr EDTA to that of /sup 99/Tcsup(m) MDP is calculated from this sample following combined injection of the two radiopharmaceuticals. The /sup 51/Cr EDTA level corrects for the glomerular filtration of /sup 99/Tcsup(m) MDP. Using this method, which only requires a gamma counter, significant differences from normal controls have been shown in patients with osteomalacia, renal osteodystrophy, Paget's disease and hypercalcaemia. The method provides routine quantitative data to add to the imaging information in the bone scan.

  10. Treatment of muscular rheumatism with 99Tc-MDP (one case report)

    International Nuclear Information System (INIS)

    Wang Jincheng

    2001-01-01

    Objective: To observe the value of using Yun Ke ( 99 Tc-MDP) to cure muscular rheumatism. Methods: A 10 years old male patient was diagnosed with muscular rheumatism. His symptoms were wandering and muscular pain and tenderness at lumbosacral region, abdomen and double crus. He was given therapy with Yun Ke everyday, intravenous injection of 5 mg for 30 days. Results: After intravenous injection of Yun Ke within 8 to 72 hours, the pain in the left crus, the lumbosacral portion and the right crus was reduced in respective order. Finally, the pain disappeared, and only the abdominal pain remained. Between 6 and 30 days, the area of abdominal pain reduced little by little to the size of 1.0 x 1.0 cm 2 , which was beside the navel. On the 33 rd day after the initial treatment, we injected him in the previous mentioned area with prednisone and the pain disappeared. Conclusion: Yun Ke ( 99 Tc-MDP) is a new medicine for the treatment of rheumatism, and we believe muscular rheumatism is a new indication of Yun Ke

  11. Visualization of femoral vessels in delayed bone scans - a sign of arteriosclerosis. A comparison of /sup 99m/Tc-MDP and /sup 99m/Tc-DPD

    Energy Technology Data Exchange (ETDEWEB)

    Lantto, T.; Jaervi, K.; Toivio, I.; Vaehaetalo, S.; Vorne, M.

    1989-05-01

    The activity of femoral vessels in delayed bone scans was evaluated visually in 237 consecutive patients and quantified in 40 female patients. In visual analysis the patients were randomly divided into three groups and in quantitative analysis into four groups of equal size. Two different MDP preparations and one DPD preparation were used as bone-seeking agents. With aging, the activity in femoral vessels increased with all agents in visual analysis, significantly with MDPs (P < 0.001) between patients less than or equal to 60 years and > 60 years. In female patients with all agents a significant increase in femoral activity was found (P < 0.001 with MDPs, P < 0.05 with DPD). In patients > 60 years, the femoral uptake was significantly higher with MDP when compared with the DPD uptake (P < 0.01 with MDP 1, P < 0.05 with MDP 2). Between the MDPs no significant differences were found. In quantitative analysis the femoral vessel to soft tissue ratio was significantly higher in patients > 70 years when compared with patients less than or equal to 50 years with MDP. No difference was found with DPD. Histological examination of excised arteries of ten patients with intense femoral uptake of MDP showed arteriosclerosis and calcification in all cases. The findings suggest that the femoral visualization in delayed bone scans is probably related to arteriosclerosis and is not a non specific finding. There may be age-related differences in the distribution of MDP and DPD.

  12. OL-DEC-MDP Model for Multiagent Online Scheduling with a Time-Dependent Probability of Success

    Directory of Open Access Journals (Sweden)

    Cheng Zhu

    2014-01-01

    Full Text Available Focusing on the on-line multiagent scheduling problem, this paper considers the time-dependent probability of success and processing duration and proposes an OL-DEC-MDP (opportunity loss-decentralized Markov Decision Processes model to include opportunity loss into scheduling decision to improve overall performance. The success probability of job processing as well as the process duration is dependent on the time at which the processing is started. The probability of completing the assigned job by an agent would be higher when the process is started earlier, but the opportunity loss could also be high due to the longer engaging duration. As a result, OL-DEC-MDP model introduces a reward function considering the opportunity loss, which is estimated based on the prediction of the upcoming jobs by a sampling method on the job arrival. Heuristic strategies are introduced in computing the best starting time for an incoming job by each agent, and an incoming job will always be scheduled to the agent with the highest reward among all agents with their best starting policies. The simulation experiments show that the OL-DEC-MDP model will improve the overall scheduling performance compared with models not considering opportunity loss in heavy-loading environment.

  13. Tc99m MDP kits, production and quality control

    International Nuclear Information System (INIS)

    Othman, I.; Yassine, T.; Lababidi, Z.; Kouli, M.

    1992-11-01

    MDP kits for labelling with Tc 99m were locally produced in different conditions, and the conditions for preparation were optimized. The quality control studies showed that the prepared kits were very good quality and comparable with that imported. Radiochemical purities ranged between 95-98% while reduced technetium ranged between 2-3% and free pertechnetate did not exceed 1%. Bioscan and biodistribution studies also showed high localization of Tc 99m in the skeleton of rats and rabbits. (author). 8 refs., 14 tabs

  14. Increased uptake of sup(99m)Tc-MDP in calcified synovial sarcoma

    International Nuclear Information System (INIS)

    Horne, T.; Mogle, P.; Finsterbush, A.; Gordin, M.; Hadassah Univ. Hospital, Mount Scopus; Hadassah Univ. Hospital, Mount Scopus

    1983-01-01

    We present a case of a partially calcified synovial sarcoma of the soft tissues of the thigh in a young girl. The roentgenographic, arteriographic and radio-nuclide scans were unusual. The finding and possible causes of increased uptake of sup(99m)Tc-MDP in synovial sarcoma are discussed. (orig.)

  15. Bone turnover markers are correlated with total skeletal uptake of 99mTc-methylene diphosphonate (99mTc-MDP)

    International Nuclear Information System (INIS)

    Lenora, Janaka; Norrgren, Kristina; Thorsson, Ola; Wollmer, Per; Obrant, Karl J; Ivaska, Kaisa K

    2009-01-01

    Skeletal uptake of 99m Tc labelled methylene diphosphonate ( 99m Tc-MDP) is used for producing images of pathological bone uptake due to its incorporation to the sites of active bone turnover. This study was done to validate bone turnover markers using total skeletal uptake (TSU) of 99m Tc-MDP. 22 postmenopausal women (52–80 years) volunteered to participate. Scintigraphy was performed by injecting 520 MBq of 99m Tc-MDP and taking whole body images after 3 minutes, and 5 hours. TSU was calculated from these two images by taking into account the urinary loss and soft tissue uptake. Bone turnover markers used were bone specific alkaline phosphatase (S-Bone ALP), three different assays for serum osteocalcin (OC), tartrate resistant acid phosphatase 5b (S-TRACP5b), serum C-terminal cross-linked telopeptides of type I collagen (S-CTX-I) and three assays for urinary osteocalcin (U-OC). The median TSU of 99m Tc-MDP was 23% of the administered activity. All bone turnover markers were significantly correlated with TSU with r-values from 0.52 (p = 0.013) to 0.90 (p < 0.001). The two resorption markers had numerically higher correlations (S-TRACP5b r = 0.90, S-CTX-I r = 0.80) than the formation markers (S-Total OC r = 0.72, S-Bone ALP r = 0.66), but the difference was not statistically significant. TSU did not correlate with age, weight, body mass index or bone mineral density. In conclusion, bone turnover markers are strongly correlated with total skeletal uptake of 99m Tc-MDP. There were no significant differences in correlations for bone formation and resorption markers. This should be due to the coupling between formation and resorption

  16. Spinal chondrosarcoma demonstrated by Tc-99m-MDP bone scan

    International Nuclear Information System (INIS)

    Smith, F.W.; Nandi, S.C.; Mills, K.

    1982-01-01

    A case of chondrosarcoma of the spine in a 45-year-old woman is described. The bone scan performed after the intravenous injection of Tc-99m-MDP not only confirmed the solitary nature of the tumor, but also demonstrated its extent within the spinous process of the second dorsal vertebra. Preoperative bone scan in the management of chondrosarcoma is advocated as a safe, noninvasive technique for assessing the extent of the tumor

  17. Muramyl dipeptide (MDP) induces reactive oxygen species (ROS) generation via the NOD2/COX-2/NOX4 signaling pathway in human umbilical vein endothelial cells (HUVECs).

    Science.gov (United States)

    Kong, Ling-Jun; Liu, Xiao-Qian; Xue, Ying; Gao, Wei; Lv, Qian-Zhou

    2018-03-20

    Vascular endothelium dysfunction caused by oxidative stress accelerates the pathologic process of cardiovascular diseases. NOD2, an essential receptor of innate immune system, has been demonstrated to play a critical role in atherosclerosis. Here, the aim of our study was to investigate the effect and underlying molecular mechanism of muramyl dipeptide (MDP) on NOX4-mediated ROS generation in human umbilical vein endothelial cells (HUVECs). 2,7-dichlorofluorescein diacetate staining was to measure the intracellular ROS level and showed MDP promoted ROS production in a time- and dose-dependent manner. The mRNA and protein levels of NOX4 and COX-2 were detected by real-time PCR and western blot. Small interfering RNA (siRNA) was used to silence NOD2 or COX-2 gene expression and investigate the mechanism of NOD2-mediated signaling pathway in HUVECs. Data showed that MDP induced NOX4 and COX-2 expression in a time- and dose-dependent manner. NOD2 knock-down suppressed up-regulation of COX-2 and NOX4 in HUVECs treated with MDP. Furthermore, silence of COX-2 in HUVECs down-regulated the NOX4 expression after MDP stimulation. Collectively, we indicated that NOD2 played a leading role in MDP-induced COX-2/NOX4/ROS signaling pathway in HUVECs, which was a novel regulatory mechanism in the progress of ROS generation.

  18. 99mTc-MDP bone uptake in secondary hyperparathyroidism: comparison among mandible, cranium, radius and femur

    International Nuclear Information System (INIS)

    Boasquevisque, Edson; Silva, Jorge Wagner Esteves da; Bernardo, Vanessa V. de Albuquerque; Macedo, Sara Mello Santana de; Boasquevisque, Camila S.

    2008-01-01

    Full text: Objective: Evaluating bone involvement in secondary hyperparathyroidism (SHPT) by 99m Tc-MDP uptake in the mandible, cranium, radius and femur and with data correlation with PTHi serum (Intact Parathyroid Hormone). Materials and Methods: In a prospective study of 54 patients with SHPT due to chronic renal disease and 15 normal individuals (control group), all patients had elevated serum PTHi, concentration and positive 99m Tc-MDP bone scintigraphy. Bone uptake measurements were carried out drawing regions-of-interest (ROI) on the mandible, posterior cranium, distal radius and proximal femur. Additionally, soft tissue uptake was measured with one region-of-interest on the internal tight soft tissue (BG). The ROI-BG ratio used as the index of normalized bone uptake. Results: The uptake differences from SHPT and control groups mainly for mandible (p = 0,001) and cranium (p = 0,002) were statistically significant, even when the SHPT groups were separated according to serum PTHi levels. There was increased bone uptake with the increased levels of PTHi serum. All of the mandibles of the SHPT patients were abnormal with 33% having focal lesions. Conclusions: The bone uptake in SHPT group was abnormal in all areas evaluated, with high uptake of 99m Tc-MDP correlated to the increase of PTHi serum concentration. (author)

  19. Successful labeling of 99mTc-MDP using 99mTc separated from 99Mo produced by 100Mo(n,2n)99Mo

    International Nuclear Information System (INIS)

    Nagai, Yasuki; Hatsukawa, Yuichi; Kin, Tadahiro; Hashimoto, Kazuyuki; Motoishi, Shoji; Konno, Chikara; Ochiai, Kentaro; Takakura, Kosuke; Sato, Yuichi; Sato, Norihito; Ohta, Akio; Yamabayashi, Hisamichi; Tanase, Masakazu; Fujisaki, Saburo; Kawauchi, Yukimasa; Teranaka, Tomoyuki; Takeuchi, Nobuhiro; Igarashi, Takashi

    2011-01-01

    We have for the first time succeeded in separating 99m Tc from a MoO 3 sample irradiated with accelerator neutrons free from any radioactive impurities and in formulating 99m Tc-methylene diphosphonate ( 99 mTc-MDP). 99 Mo, the mother nuclide of 99m Tc, was produced by the 100 Mo(n,2n) 99 Mo reaction using about 14 MeV neutrons provided by the 3 H(d,n) 4 He reaction at the Fusion Neutronics Source of Japan Atomic Energy Agency. The 99m Tc was separated from 99 Mo by sublimation and its radionuclide purity was confirmed to be higher than 99.99% by γ-spectroscopy. The labeling efficiency of 99m Tc-MDP was shown to be higher than 99% by thin-layer chromatography. These values exceed the United States Pharmacopeia requirements for a fission product, 99 Mo. Consequently, a 99m Tc radiopharmaceutical preparation formed by using the mentioned 99 Mo can be a promising substitute for the fission product 99 Mo, which is currently produced using a highly enriched uranium target in aging research reactors. A longstanding problem to ensure a reliable and constant supply of 99 Mo in Japan can be partially mitigated. (author)

  20. Clinical investigation of accumulation process of {sup 99m}Tc-HMDP and -MDP in bone

    Energy Technology Data Exchange (ETDEWEB)

    Matumoto, Takahiro [Health Insurance Naruto Hospital, Tokushima (Japan); Miyoshi, Hirokazu; Satou, Kazuo; Kishi, Taro; Yoshino, Tomio; Nishitani, Hiromu

    2000-06-01

    The accumulation process in bone of {sup 99m}Tc-hydroxymethylene diphosphonate ({sup 99m}Tc-HMDP) and {sup 99m}Tc-methylene diphosphonate ({sup 99m}Tc-MDP) was examined on 9 subjects (5 for {sup 99m}Tc-HMDP and 4 for {sup 99m}Tc-MDP). {sup 99m}Tc compounds in blood were analyzed with radio-thinlayer chromatography, radioactivity was measured using a scintillation counter, and the uptake of both {sup 99m}Tc diphosphonates in bone was examined by scintigraphy. The amounts of {sup 99m}Tc-HMDP and MDP compounds disappeared from blood for 2 h after injection were 83% and 87%, respectively, and these were almost unchanged even after 3 h. While the greater part of {sup 99m}TcO{sub 4}{sup -} contained in both diphosphonates was disappeared from blood, the small amounts of unknown {sup 99m}Tc compounds were produced in blood. The ratio of the radioactivity of {sup 99m}Tc-HMDP in lumbar vertebra to soft tissue near bone was 1.5{+-}0.5 after about 3 h, showing that equilibrium occurred in the process of the accumulation in bone, and good scintigrams were depicted in all the cases. These results suggest that the accumulation in bone of both {sup 99m}Tc diphosphonates may be by both fast chemical absorption onto the surface of the hydroxyapatite in bone and slow uptake mediated through osteoblast-like cells and organic matters. (author)

  1. 99mTc-MDP bone uptake in secondary hyperparathyroidism. Comparison of the mandible, cranium, radius, and femur

    International Nuclear Information System (INIS)

    Boasquevisque, Edson; Mandarim-de-Lacerda, Carlos A.; Silva, Jorge Wagner Esteves da; Albuquerque Bernardo, V.V. de; Macedo, S. Mello Santana de; Oliveira, Andre Ribeiro Nogueira de; Pires Kasai, Erika Tami; Boasquevisque, Camila S.

    2008-01-01

    The objective of this study to evaluate the bone involvement of the mandible, cranium, radius, and femur in secondary hyperparathyroidism (SHPT) using 99m Tc-methylene diphosphonate sodium (MDP) uptake correlated with the serum intact parathyroid hormone (PTHi). In a prospective study of 54 patients with SHPT due to chronic renal disease and 15 normal individuals (control group), all patients had elevated serum PTHi and 99m Tc-MDP bone scintigraphy. Bone uptake was measured in regions of interest (ROIs) in the mandible posterior cranium, distal radius, and proximal femur. In addition, soft tissue uptake was measured in one ROI in the soft tissues of the medial thigh (BG). The ROI-BG ratio was used as an index of the normalized bone uptake. The uptake differences in the SHPT and control groups were statistically significant for the mandible (P=0.001) and cranium (P=0.002). When the SHPT group was subclassified according to serum PTHi levels, the bone uptake increased with the serum PTHi level. All mandibles of the patients with SHPT were abnormal, and 33% had focal lesions. The bone uptake in the SHPT group was abnormal in all areas evaluated, and a high uptake of 99m Tc-MDP was correlated with an increased serum PTHi. (author)

  2. Comparison of facet joint activity on 99mTc-MDP SPECT/CT with facet joint signal change on MRI with fat suppression.

    Science.gov (United States)

    Lehman, Vance T; Murphy, Robert C; Schenck, Louis A; Carter, Rickey E; Johnson, Geoffrey B; Kotsenas, Amy L; Morris, Jonathan M; Nathan, Mark A; Wald, John T; Maus, Timothy P

    2016-01-01

    We compared signal change on magnetic resonance imaging (MRI) with fat suppression and bone scan activity of lumbar facet joints to determine if these two imaging findings are correlated. We retrospectively identified all patients who underwent imaging of the lumbar spine for pain evaluation using both technetium-99m methylene disphosphonate single-photon emission computed tomography/computed tomography (99mTc-MDP SPECT/CT) and MRI with at least one fat-suppressed T2- or T1-weighted sequence with gadolinium enhancement within a 180-day interval, at our institution between 1 January 2008 and 19 February 2013. Facet joint activity on 99mTc-MDP SPECT/CT and peri-facet signal change on MRI were rated as normal or increased. Agreement between the two examination types were determined with the κ and prevalence-adjusted bias-adjusted κ (PABAK) statistics. This study included 60 patients (28 male, 47%), with a mean age of 49±19.7 years (range, 12-93 years). The κ value indicated no agreement between 99mTc-MDP SPECT/CT and MRI (κ=-0.026; 95% confidence interval: -0.051, 0.000). The PABAK values were fair to high at each spinal level, which suggests that relatively low disease prevalence lowered the κ values. Together, the κ and PABAK values indicate that there is some degree of intermodality agreement, but that it is not consistent. Overall, facet joint signal change on fat-suppressed MRI did not always correlate with increased 99mTc-MDP SPECT/CT activity. MRI and 99mTc-MDP SPECT/CT for facet joint evaluation should not be considered interchangeable examinations in clinical practice or research.

  3. Inclusão de feixes de sisal na produção de painéis MDP de eucalipto

    DEFF Research Database (Denmark)

    de Almeida Mesquita, Ricardo G; Mendes, Lourival Marin; Mendes, Rafael Farinassi

    2015-01-01

    of the plastic industry. This lignocellulose material has gained prominence due to several mechanical and economic characteristics. Thus, the aim of this study was to evaluate the potential use of sisal bundles in association with eucalyptus particles for the production of MDP panels. Panels were prepared...... with the substitution on eucalyptus wood for sisal bundles in the panels’ core in doses of 0, 5, 10, 15, 20 and 25%. The MDP panels were produced with face/core 40/60 (base dry mass of the particles), urea-formaldehyde adhesive, nominal density of 0,70 g.cm-3 and pressing cycle of 8 minutes, 3,92 MPa pressure...

  4. Clinical experience of 123I-IMP scintigraphy in detecting vertebral bone metastases of hepatocellular carcinoma. A comparison with bone scintigraphy with 99mTc-MDP

    International Nuclear Information System (INIS)

    Suto, Y.; Iwamiya, T.; Tanigawa, N.; Shabana, M.; Ohta, Y.

    1994-01-01

    123 I-IMP and bone scintigraphy with 99m Tc-MDP were consecutively performed in patients with vertebral bone metastases from hepatocellular carcinoma and lumbar spondylosis deformans in a 7-day interval or shorter. The intensity of uptake was compared. Eighteen of the 20 metastatic lesions (90%) were classified as increased uptake areas in 123 I-IMP scintigraphy. MDP-scintigraphy disclosed 16 metastatic lesions (80%), 9 as ''hot'' lesions (56%) and 7 as ''cold'' lesions (44%). 123 I-IMP scintigraphy was negative in all 12 lesions of lumbar spondylosis deformans. Compared to MDP-scintigraphy, 123 I-IMP scintigraphy was more sensitive in detecting vertebral bone metastases of hepatocellular carcinoma with smaller rates of false-positive and false-negative findings. (orig./MG)

  5. Clinical approach to renal study incidental to {sup 99m}Tc-MDP bone scintigraphy

    Energy Technology Data Exchange (ETDEWEB)

    Takayama, Teruhiko; Onoguchi, Masahisa; Mizukami, Yuji; Koshida, Kichiro; Tsuji, Shiro [Kanazawa Univ. (Japan). School of Health Sciences; Kinuya, Seigo; Kobashi, Kazunori; Tonami, Norihisa

    2001-06-01

    In order to investigate the feasibility of the assessment of renal function with {sup 99m}Tc-MDP, we compared renographical images, renogram patterns and the glomerular filtration rate (GFR) obtained by means of a modified Gates' method and 200 MBq of {sup 99m}Tc-MDP with those obtained by means of {sup 99m}Tc-DTPA. Because 19 of 20 patients had malignant tumors in the genitourinary tract, there was no difference between the two tracers in identifying a parenchymal defect corresponding to renal cancer. Of eight patients with hydronephrosis, four had a defect or decreased uptake with a dilated pelvis, whereas the other four had marked radioisotope retention in the renal pelvis or the whole kidney on serial images. There was also no difference between the two tracers in identifying hydronephrosis. Of 38 paired renograms 35 showed the same renogram patterns with both tracers. Of three patients with different renogram patterns, two had hydronephrosis. In 20 patients including three patients with bone metastasis, total GFR and split GFR obtained with both tracers correlated with a correlation coefficient of r=0.920 (p<0.001) and r=0.944 (p<0.001), respectively. Excluding bone metastasis from the analysis, a linear-regression analysis showed excellent agreement between the two measurements with a correlation coefficient of r=0.960 (p<0.001) and r=0.963 (p<0.001), respectively. The linear regression equations were Y=1.009X - 0.111 and Y=1.034X - 0.714, respectively. In conclusion, {sup 99m}Tc-MDP can be used as a supplement to evaluate renal function incidental to the survey of bone metastases in patients with malignant tumor. (author)

  6. DEVELOPMENT AND DEPLOYMENT ASSESSMENT OF A MELT-DOWN PROOF MODULAR MICRO REACTOR (MDP-MMR)

    Energy Technology Data Exchange (ETDEWEB)

    Hawari, Ayman I.; Venneri, Francesco

    2018-04-02

    The objective of this project is to perform feasibility assessment and technology gap analysis and establish a development roadmap for an innovative and highly compact Micro Modular Reactor (MMR) concept that integrates power production, power conversion and electricity generation in a single unit. The MMR is envisioned to use fully ceramic micro-encapsulated (FCM) fuel, a particularly robust form of TRISO fuel, and to be gas-cooled (e.g., He or CO2) and capable of generating power in the range of 10 to 40 MW-thermal. It is designed to be absolutely melt-down proof (MDP) under all circumstances including complete loss of coolant scenarios with no possible release of radioactive material, to be factory produced, to have a cycle length of greater than 20 years, and to be highly proliferation resistant. In addition, it will be transportable, retrievable and suitable for use in remote areas. As such, the MDP-MMR will represent a versatile reactor concept that is suitable for use in various applications including electricity generation, process heat utilization and propulsion.

  7. Interactive reliability assessment using an integrated reliability data bank

    International Nuclear Information System (INIS)

    Allan, R.N.; Whitehead, A.M.

    1986-01-01

    The logical structure, techniques and practical application of a computer-aided technique based on a microcomputer using floppy disc Random Access Files is described. This interactive computational technique is efficient if the reliability prediction program is coupled directly to a relevant source of data to create an integrated reliability assessment/reliability data bank system. (DG)

  8. Diagnostic role of (99)Tc(m)-MDP SPECT/CT combined SPECT/MRI Multi modality imaging for early and atypical bone metastases.

    Science.gov (United States)

    Chen, Xiao-Liang; Li, Qian; Cao, Lin; Jiang, Shi-Xi

    2014-01-01

    The bone metastasis appeared early before the bone imaging for most of the above patients. (99)Tc(m)-MDP ((99)Tc(m) marked methylene diphosphonate) bone imaging could diagnosis the bone metastasis with highly sensitivity, but with lower specificity. The aim of this study is to explore the diagnostic value of (99)Tc(m)-MDP SPECT/CT combined SPECT/MRI Multi modality imaging for the early period atypical bone metastases. 15 to 30 mCi (99)Tc(m)-MDP was intravenously injected to the 34 malignant patients diagnosed as doubtful early bone metastases. SPECT, CT and SPECT/CT images were captured and analyzed consequently. For the patients diagnosed as early period atypical bone metastases by SPECT/CT, combining the SPECT/CT and MRI together as the SPECT/MRI integrated image. The obtained SPECT/MRI image was analyzed and compared with the pathogenic results of patients. The results indicated that 34 early period doubtful metastatic focus, including 34 SPECT positive focus, 17 focus without special changes by using CT method, 11 bone metastases focus by using SPECT/CT method, 23 doubtful bone metastases focus, 8 doubtful bone metastases focus, 14 doubtful bone metastases focus and 2 focus without clear image. Totally, SPECT/CT combined with SPECT/MRI method diagnosed 30 bone metastatic focus and 4 doubtfully metastatic focus. In conclusion, (99)Tc(m)-MDP SPECT/CT combined SPECT/MRI Multi modality imaging shows a higher diagnostic value for the early period bone metastases, which also enhances the diagnostic accuracy rate.

  9. Model-based virtual VSB mask writer verification for efficient mask error checking and optimization prior to MDP

    Science.gov (United States)

    Pack, Robert C.; Standiford, Keith; Lukanc, Todd; Ning, Guo Xiang; Verma, Piyush; Batarseh, Fadi; Chua, Gek Soon; Fujimura, Akira; Pang, Linyong

    2014-10-01

    A methodology is described wherein a calibrated model-based `Virtual' Variable Shaped Beam (VSB) mask writer process simulator is used to accurately verify complex Optical Proximity Correction (OPC) and Inverse Lithography Technology (ILT) mask designs prior to Mask Data Preparation (MDP) and mask fabrication. This type of verification addresses physical effects which occur in mask writing that may impact lithographic printing fidelity and variability. The work described here is motivated by requirements for extreme accuracy and control of variations for today's most demanding IC products. These extreme demands necessitate careful and detailed analysis of all potential sources of uncompensated error or variation and extreme control of these at each stage of the integrated OPC/ MDP/ Mask/ silicon lithography flow. The important potential sources of variation we focus on here originate on the basis of VSB mask writer physics and other errors inherent in the mask writing process. The deposited electron beam dose distribution may be examined in a manner similar to optical lithography aerial image analysis and image edge log-slope analysis. This approach enables one to catch, grade, and mitigate problems early and thus reduce the likelihood for costly long-loop iterations between OPC, MDP, and wafer fabrication flows. It moreover describes how to detect regions of a layout or mask where hotspots may occur or where the robustness to intrinsic variations may be improved by modification to the OPC, choice of mask technology, or by judicious design of VSB shots and dose assignment.

  10. Preoperative sup(99m)Tc-MDP scintimetry of femoral neck fractures

    International Nuclear Information System (INIS)

    Holmberg, S.; Thorngren, K.-G.

    1984-01-01

    Preoperative sup(99m)Tc-MDP-scintimetry was performed in 117 patients with femoral neck fractures. Scintimetry was shown to be superior to visual evaluation. The ratio was calculated of the uptake in the femoral head of the fractured side over that in the unfractured side, with compensation for the increased trochanteric femoral activity found on the fractured side. A ratio above 0.90 correlated well with uneventful healing in both undisplaced and displaced fractures. Preoperative scintimetry is of great value in the choice of primary treatment of femoral neck fractures. (author)

  11. Biological properties of 99Tcm-HMIBP and its usefulness for bone scintigraphy by comparing with 99Tcm-MDP

    International Nuclear Information System (INIS)

    Luo Shineng; Ye Wanzhong; Xie Minhao; Yu Yanhua; Zhao Yan; Cao Guoxian; Guo Xuehua; Zhou Lian

    2008-01-01

    Objective: Zoledronate has been extensively used for the treatment of tumor-induced hypercalcaemia and osteolytic bone metastases. 1-hydroxy-2-(1-methylimidazol-2-yl) ethylidene-1,1-bisphos- phonic acid (HMIBP) with similar chemical structure as Zoledronate, was therefore considered to be useful as bone imaging agent. In this study the usefulness of 99 Tc m labeled HMIBP for bone imaging was evaluated and the results with the well-established 99 Tc m -methylene diphosphonic acid (MDP) imaging was compared. Methods: Labeled with 99 Tc m , the SnCl 2 ·2H 2 O quantity, radiochemical purity, pH value and stability at 4 degree C of 99 Tc m -HMIBP were measured. Besides, the partition coefficient, plasma protein binding rate, hemodynamic parameters of 99 Tc m -HMIBP and median lethal dose (LD 50 ) of HMIBP were determined. 99 Tc m -HMIBP bone imaging was performed in normal New Zealand rabbits and compared with 99 Tc m -MDP bone imaging. Results: The kit composed of 5 mg HMIBP and 0.05 mg SnCl 2 ·2H 2 O. The labeling rate was 96% after 180 d storage at 4 degree C. The radiochemical purity of 99 Tc m -HMIBP was 98% at pH 5 and the partition coefficients were 0.0125 and 0.0054 at pH 7.0 and 7.4 respectively. The plasma protein binding rate of 99 Tc m -HMIBP was 44.77%. The hemodynamic parameter C valued 3.0979 e -0.0721t +0.1250 e -0.0076t and LD 50 was 8.2 mg/kg. The bone images of 99 Tc m -HMIBP were fairly well 3 h after the injection, which was comparable to 99 Tc m -MDP bone imaging. Conclusions: 99 Tc m -HMIBP had good biological properties and comparable bone imaging quality with 99 Tc m -MDP. It might be a potential agent for both treatment and imaging. (authors)

  12. A comparative study of 18F-fluorodeoxyglucose positron emission tomography/computed tomography and 99mTc-MDP whole-body bone scanning for imaging osteolytic bone metastases

    International Nuclear Information System (INIS)

    Zhang, Lin; Chen, Lihua; Xie, Qiao; Zhang, Yongke; Cheng, Lin; Li, Haitao; Wang, Jian

    2015-01-01

    The objective of this study was to evaluate the feasibility and diagnostic value of 18 F-fluorodeoxyglucose positron emission tomography/computed tomography ( 18 F-FDG PET/CT) and 99m Tc-methylenediphosphonate (MDP) whole-body bone scanning (BS) for the detection of osteolytic bone metastases. Thirty-four patients with pathologically confirmed malignancies and suspected osteolytic bone metastases underwent 18 F-FDG PET/CT and 99m Tc-MDP whole-body BS within 30 days. The sensitivity, specificity, and accuracy with respect to the diagnosis of osteolytic bone metastases and bone lesions were compared between the two imaging methods. The sensitivity, specificity, and accuracy of 18 F-FDG PET/CT for the diagnosis of osteolytic bone metastases were 94.3% (95% confidence interval [CI], 91.6–96.2%), 83.3% (95% CI, 43.6–96.9%), and 94.2% (95% CI, 91.5–96.1%), respectively. It was found that 99m Tc-MDP whole-body BS could discriminate between patients with 50.2% (95% CI, 45.4–55.1%) sensitivity, 50.0% (95% CI, 18.8–81.2%) specificity, and 50.2% (95% CI, 45.5–55.1%) accuracy. 18 F-FDG PET/CT achieved higher sensitivity, specificity, and accuracy in detecting osteolytic bone metastases than 99mTc-MDP whole-body BS (p<0.001). F-FDG PET/CT has a higher diagnostic value than 99m Tc-MDP whole-body BS in the detection of osteolytic bone metastases, especially in the vertebra

  13. 75 FR 35011 - Combined Notice of Filings #1

    Science.gov (United States)

    2010-06-21

    ... Processes Manual Incorporating Proposed Revisions to the Reliability Standards Development Process. Filed..., June 21, 2010. Take notice that the Commission received the following electric reliability filings: Docket Numbers: RR10-12-000. Applicants: North American Electric Reliability Corp. Description: Petition...

  14. Detection of breast cancer microcalcification using 99mTc-MDP SPECT or Osteosense 750EX FMT imaging

    International Nuclear Information System (INIS)

    Felix, Dayo D.; Gore, John C.; Yankeelov, Thomas E.

    2015-01-01

    Background: In previous work, we demonstrated the presence of hydroxyapetite (type II microcalcification), HAP, in triple negative MDA-MB-231 breast cancer cells. We used 18 F-NaF to detect these types of cancers in mouse models as the free fluorine, 18 F − , binds to HAP similar to bone uptake. In this work, we investigate other bone targeting agents and techniques including 99m Tc-MDP SPECT and Osteosense 750EX FMT imaging as alternatives for breast cancer diagnosis via targeting HAP within the tumor microenvironment. Methods: Thirteen mice were injected subcutaneously in the right flank with 10 6 MDA-MB-231 cells. When the tumor size reached ~ 0.6 cm 3 , mice (n = 9) were injected with ~ 37 MBq of 99m Tc-MDP intravenously and then imaged one hour later in a NanoSPECT/CT or injected intravenously with 4 nmol/g of Osetosense 750EX and imaged 24 hours later in an FMT (n = 4). The imaging probe concentration in the tumor was compared to that of muscle. Following SPECT imaging, the tumors were harvested, sectioned into 10 μm slices, and underwent autoradiography or von Kossa staining to correlate 99m Tc-MDP binding with HAP distribution within the tumor. The SPECT images were normalized to the injected dose and regions-of-interest (ROIs) were drawn around bone, tumor, and muscle to obtain the radiotracer concentration in these regions in units of percent injected dose per unit volume. ROIs were drawn around bone and tumor in the FMT images as no FMT signal was observed in normal muscle. Results: Uptake of 99m Tc-MDP was observed in the bone and tumor with little or no uptake in the muscle with concentrations of 11.34 ± 1.46 (mean ± SD), 2.22 ± 0.95, and 0.05 ± 0.04 %ID/cc, respectively. Uptake of Osteosense 750EX was also observed in the bone and tumor with concentrations of 0.35 ± 0.07 (mean ± SD) and 0.04 ± 0.01 picomoles, respectively. No FMT signal was observed in the normal muscle. There was no significant difference in the bone-to-tumor ratio between

  15. 78 FR 15361 - Combined Notice of Filings #1

    Science.gov (United States)

    2013-03-11

    ... electric reliability filings: Docket Numbers: RR13-2-000. Applicants: North American Electric Reliability Corporation, Description: Petition of North American Electric Reliability Corporation for Approval of Revisions to the NERC Standard Processes Manual. Filed Date: 2/28/13. Accession Number: 20130228-5212...

  16. Myocardial uptake of Tc-99m MDP in chronic renal failure with cardiomyopathy

    International Nuclear Information System (INIS)

    Kim, Seung Eun; Sohn, Hyung Sun; Chung, Yong An; Park, Young Ha; Kim, Sung Hoon; Chung, Soo Kyo

    2000-01-01

    A uremic patient on hemodialysis, who had concurrent cardiomyopathy showed intense myocardial uptake of 99m Tc-methylene diphosphonate (MDP). The presumed cause of uptake in the myocardium is metastatic calcification due to hypercalcemia secondary to the renal failure. However, supplementary mechanism caused by cardiomyopathy should be considered. We describe a case with bone tracer uptake in the myocardium in the absence of infarction in a patient with chronic renal failure.=20

  17. The diagnostic value of monoclonal antibody scan (leucoscan) compared with 99mTc MDP bone scan and Ga 67 in diagnosing bone and joint infection

    International Nuclear Information System (INIS)

    Koukouraki, S.I.; Velidaki, A.; Prassopoulos, V.; Karkavitsas, N.; Vavouranakis, H.; Hatjipavlou, A.

    2002-01-01

    Full text: Nowadays different radiopharmaceuticals have been developed as 99mTc MDP, 67Ga citrate, 111In oxine- and 99mTc HMPAO labeled leucocytes for the accurate localization of bone/joint infection, but all of them have limitations that encouraged the search of new agents characterized from high and early uptake in infectious/inflammatory tissues, low toxicity and no accumulation in non inflamed tissues. The purpose of this study is to compare the diagnostic value of a 99mTc labeled antigranulocyte Fab' fragment (Leucoscan) with 99mTc MDP bone scan and 67 Ga. The monoclonal antibody, Leucoscan, is an IgG murine Fab' fragment directed against a NCA-90 epitope located on the surface of granulocytes. 45 patients with suspected bone and joint infection (18 total hip prosthesis, 4 knee prosthesis, 8 vertebral infection and 15 long bones) were included in this study. All patients underwent conventional Rx, bone scan, 67Ga scan and Leucoscan. Three phase 99mTc MDP bone scan and 67Ga scan were performed using standard procedures. For Leucoscan the antibody was labeled with 25 mCi of 99mTc and was infected intravenously over 30 seconds. Ten minutes planar images were taken 1 h and 2 hrs p.i using a GE Millennium γ camera provided with a LEGP collimator. Images were evaluated as score 1 (no abnormal uptake), score 2 (probably positive), score 3 (definitely infected) according the intensity of abnormally increased uptake. Results were compared with 99mTc MDP bone scan and 67Ga scans. The final diagnosis was given by the surgical verification with histopathology or culture. All 45 patients had pathologic proof of presence/absence of bone and joint infection. 36/45 were positive for bone or joint infection and 9/45 were negative.30/36 patients with surgically proven bone and joint infection had true positive Leucoscan, 26/36 had true positive MDP bone scan and 20/36 true positive 67Ga scan. Nine out of 9 patients with proven absence of inflammation had true negative

  18. The scintigraphy of sacroiliac joints. A comparison of 99mTc-DPD and 99mTc-MDP

    International Nuclear Information System (INIS)

    Lantto, T.

    1990-01-01

    The accumulation of 99m Tc-methylene diphosphonate ( 99m Tc-MDP) and 99m Tc-dicarboxypropane diphosphonate ( 99m Tc-DPD) in sacroiliac (si) joints was evaluated as a function of imaging time in 22 control patients and 5 patients with sacroiliitis. The controls were injected with either 99m Tc-DPD or 99m Tc-MDP (12 and 10 patients, respectively) and the patients with sacroiliitis with both agents within 5 days. Both the anterior and posterior views of the si joints were taken. The sacroiliac joint-to-sacrum (SI/S) ratio was calculated with the region of interest method. No statistically significant differences between these bone-seeking agents were found in the SI/S ratios of the control or the diseased patients. A clear overlap of indices (mean±SD) was found between the control patients and the patients with sacroiliitis. When the inflamed si joint was divided into three small adjacent areas and the SI/S ratios calculated for these areas, a statistically significant (P 99m Tc-DPD and in most patients injected with 99m Tc-MDP. In the posterior views, the significance was less marked. In every case, the inflamed part of the si joint was visible in the anterior views. The background subtraction had the greatest effect on the SI/S ratio of anterior images, but in the posterior views no significance was found. The low specificity of sacroiliac joint imaging must be taken into consideration when the results are interpreted. (orig.)

  19. Evaluation of the in vivo binding of 99mTc-MDP on serum proteins

    International Nuclear Information System (INIS)

    Freitas, R.S.F.; Mattos, D.M.M.; Gomes, M.L.; Moreno, S.R.F.; Lima, E.A.C.; Dire, G.F.; Aleixo, L.C.M.; Lima Filho, G.L.; Bernardo-Filho, M.

    2002-01-01

    Aim: In the clinical application of technetium-99m-radiopharmaceuticals (99mTc) these agents are injected into the blood stream and they may bind reversibly and irreversibly to the blood proteins. To evaluate the protein binding of the radiopharmaceutical, the protein-bound 99mTc-radiopharmaceuticals must be separated from the free 99mTc-radiopharmaceuticals complexes. This has been accomplished by precipitation of the proteins. In this study, we have compared the results obtained with the evaluation of the binding of the radiopharmaceutical Tc-99m methylenediphosphonic acid (99mTc-MDP) on serum proteins using precipitation methods with TCA and AS. Material and Methods: 99mTc-MDP was administrated in Wistar rats and after 10 minutes blood was withdrawn and serum (S) isolated. Aliquots of S were precipitated with 1 ml of TCA or AS at various concentrations (0.1, 0.5, 1.0, 5.0, 10.0 and 20.0%) and soluble (SF) and insoluble fractions (IF) were separated. The samples (IF-S and SF-S) were counted in a well counter with NaI(TI)crystal. The percent of the radioactivity (%ATI) was determined in each fraction. Results: The results obtained with the comparison of the in vivo binding of 99mTc-MDP when the precipitation was performed with TCA showed that the %ATI was only statistically different (ANOVA, p<0.05) to the 20% TCA concentration. When various concentrations of AS were used no differences in the %ATI were found and the results were similar to the obtained with TCA, except to the concentration of 20%(TCA - 51.70 ± 10.19 and SA - 10.17 ± 0.98 %). Conclusion: It is possible to suggest that the different concentrations of the precipitating agents (TCA and AS) act, in general, on the same binding sites of the evaluate radiopharmaceutical to the proteins of the serum, except to concentration of 20%

  20. 77 FR 47831 - Combined Notice of Filings #1

    Science.gov (United States)

    2012-08-10

    ... Corporation for Approval of an Interpretation to Reliability Standard CIP-004-4--Personnel and Training. Filed... Due: 5 p.m. ET 8/23/12. Take notice that the Commission received the following electric reliability filings. Docket Numbers: RD12-5-000. Applicants: North American Electric Reliability Corporation...

  1. Clinical experience of [sup 123]I-IMP scintigraphy in detecting vertebral bone metastases of hepatocellular carcinoma. A comparison with bone scintigraphy with [sup 99m]Tc-MDP

    Energy Technology Data Exchange (ETDEWEB)

    Suto, Y. (Dept. of Radiology, Tottori Univ. Faculty of Medicine, Yonago (Japan) Dept. of Radiology, Matsue City Hospital (Japan)); Iwamiya, T. (Dept. of Radiology, Tottori Univ. Faculty of Medicine, Yonago (Japan) Dept. of Radiology, Matsue City Hospital (Japan)); Tanigawa, N. (Dept. of Radiology, Tottori Univ. Faculty of Medicine, Yonago (Japan) Dept. of Radiology, Matsue City Hospital (Japan)); Shabana, M. (Dept. of Radiology, Tottori Univ. Faculty of Medicine, Yonago (Japan) Dept. of Radiology, Matsue City Hospital (Japan)); Ohta, Y. (Dept. of Radiology, Tottori Univ. Faculty of Medicine, Yonago (Japan) Dept. of Radiology, Matsue City Hospital (Japan))

    1994-03-01

    [sup 123]I-IMP and bone scintigraphy with [sup 99m]Tc-MDP were consecutively performed in patients with vertebral bone metastases from hepatocellular carcinoma and lumbar spondylosis deformans in a 7-day interval or shorter. The intensity of uptake was compared. Eighteen of the 20 metastatic lesions (90%) were classified as increased uptake areas in [sup 123]I-IMP scintigraphy. MDP-scintigraphy disclosed 16 metastatic lesions (80%), 9 as ''hot'' lesions (56%) and 7 as ''cold'' lesions (44%). [sup 123]I-IMP scintigraphy was negative in all 12 lesions of lumbar spondylosis deformans. Compared to MDP-scintigraphy, [sup 123]I-IMP scintigraphy was more sensitive in detecting vertebral bone metastases of hepatocellular carcinoma with smaller rates of false-positive and false-negative findings. (orig./MG).

  2. Radiopharmacokinetic data for 99mTc-ABP - A new radiopharmaceutical for bone scanning: Comparison with 99mTc-MDP

    International Nuclear Information System (INIS)

    Murphy, Consuelo Arteaga de; Melendez-Alafort, Laura; Montoya-Molina, Carlos E.; Sepulveda-Mendez, Jesus

    1997-01-01

    Technetium-99m-labeled alendronate is a new radiopharmaceutical for bone scanning developed under strict quality control at the INNSZ. The purpose of this work was to compare the radiopharmacokinetic data and the dosimetry of 99m Tc-ABP and 99m Tc-MDP in 10 volunteers, after it was tested in laboratory animals. 99m Tc-ABP has shorter mean residence time (MRT) and t (1(2)) β; is less protein bound; has a higher renal clearance; smaller Vdss, and similar bone uptake at 1 and 2 h. 99m Tc-ABP gives less radiation exposure to the patient with a 740 MBq dose, and the quality of the bone scan is excellent. 99m Tc-ABP is a better radiopharmaceutical than 99m Tc-MDP for bone scanning

  3. MDP-based resource allocation for triple-play transmission on xDSL systems

    Science.gov (United States)

    de Souza, Lamartine V.; de Carvalho, Glaucio H. S.; Cardoso, Diego L.; de Carvalho, Solon V.; Frances, Carlos R. L.; Costa, João C. W. A.; Riu, Jaume Rius i.

    2007-09-01

    Many broadband services are based on multimedia applications, such as voice over internet protocol (VoIP), video conferencing, video on demand (VoD), and internet protocol television (IPTV). The combination "triple-play" is often used with IPTV. It simply means offering voice, video and data. IPTV and others services uses digital broadband networks such as ADSL2+ (Asymmetric Digital Subscriber Line) and VDSL (Very High Rate DSL) to transmit the data. We have formulated a MDP (Markov Decision Process) for a triple-play transmission on DSL environment. In this paper, we establish the relationship between DSL transmission characteristics and its finite-state Markov model for a triple-play transmission system. This relationship can be used for a resource management for multimedia applications delivered through a broadband infrastructure. The solution to our optimization problem can be found using dynamic programming (DP) techniques, such as value iteration and its variants. Our study results in a transmission strategy that chooses the optimal resource allocation according the triple-play traffic requirements, defined in technical report TR-126 (Triple-Play Services Quality of Experience Requirements) from DSL Forum, minimizing quality of service (QoS) violations with respect to bandwidth. Three traffic classes (video, audio, and best effort internet data) are defined and analyzed. Our simulation results show parameters like as blocking probability for each class, link utilization and optimal control policies. The MDP-based approach provides a satisfactory way of resource management for a DSL system.

  4. Molecular adjuvants based on nonpyrogenic lipophilic derivatives of norAbuMDP/GMDP formulated in nanoliposomes: stimulation of innate and adaptive immunity.

    Science.gov (United States)

    Knotigová, Pavlína Turánek; Zyka, Daniel; Mašek, Josef; Kovalová, Anna; Křupka, Michal; Bartheldyová, Eliška; Kulich, Pavel; Koudelka, Štěpán; Lukáč, Róbert; Kauerová, Zuzana; Vacek, Antonín; Horynová, Milada Stuchlová; Kozubík, Alois; Miller, Andrew D; Fekete, Ladislav; Kratochvílová, Irena; Ježek, Jan; Ledvina, Miroslav; Raška, Milan; Turánek, Jaroslav

    2015-04-01

    The aim of this work was to demonstrate an immunostimulatory and adjuvant effect of new apyrogenic lipophilic derivatives of norAbuMDP and norAbuGMDP formulated in nanoliposomes. Nanoliposomes and metallochelating nanoliposomes were prepared by lipid film hydration and extrusion methods. The structure of the liposomal formulation was studied by electron microscopy, AF microscopy, and dynamic light scattering. Sublethal and lethal γ-irradiation mice models were used to demonstrate stimulation of innate immune system. Recombinant Hsp90 antigen (Candida albicans) bound onto metallochelating nanoliposomes was used for immunisation of mice to demonstrate adjuvant activities of tested compounds. Safety and stimulation of innate and adaptive immunity were demonstrated on rabbits and mice. The liposomal formulation of norAbuMDP/GMDP was apyrogenic in rabbit test and lacking any side effect in vivo. Recovery of bone marrow after sublethal γ-irradiation as well as increased survival of mice after lethal irradiation was demonstrated. Enhancement of specific immune response was demonstrated for some derivatives incorporated in metallochelating nanoliposomes with recombinant Hsp90 protein antigen. Liposomal formulations of new lipophilic derivatives of norAbuMDP/GMDP proved themselves as promising adjuvants for recombinant vaccines as well as immunomodulators for stimulation of innate immunity and bone-marrow recovery after chemo/radio therapy of cancer.

  5. The Findings of 99mTc-MDP Bone Scan in Primary malignant Bone Tumors

    International Nuclear Information System (INIS)

    Hyun, In Young; Lee, Kung Han; Lee, Dong Soo; Chung, June Key; Lee, Myung Chul; Koh, Chang Soon; Kang, Heung Sik; Lee, Sang Hoon; Lee, Han Koo

    1995-01-01

    Tc-99m-MDP bone scan was performed in 31 patients with primary malignant bone tumors, 22 patients with osteogenic sarcoma, 5 patients with chondrosarcoma and 4 patients with Ewing's sarcoma. The findings were classified by isotope intensity of accumulation in tumor as grade 1 to 3, overall pattern of isotope distribution in tumor as grade 1 to 3, and distortion of bony outline as grade 1 to 3. Histologic classifications were correlated with scan findings in 22 patients with osteogenic sarcoma. The results were as follows. 1) In 22 patients with osteogenic sarcoma, markedly increased isotope intensity higher than sacroiliac joint with patchy areas of decreased intensity and severe bony distortion were found in 16 patients. The correlations between histologic classification and scan findings were not discovered. 2) In 5 patients with chondrosarcoma, mildly increased isotope intensity with patchy areas of increased intensity and mild bony distortion were found in 4 patients. 3) In 4 patients with Ewing's sarcoma, markedly increased homogenous intensity with moderate bony distortion were found in 3 patients. Conclusively there were common findings in each 3 primary malignant bone tumors and Tc-99m-MDP bone scan was complemented with radiologic studies in differentiating primary malignant bone tumors.

  6. A comparative study of 99Tcm-MDP, 99Tcm(V)-DMSA and 99Tcm-Citrate in diagnosis of bone malignant tumors and bone/joint infections

    International Nuclear Information System (INIS)

    Wu Zhaozhong; Wu Boyi; Lin Wei; Wei Xueli; Wu Hengfu; Fan Ziwen; Ouyang Zhi; Wu Changwei; Yuan Gewen

    2003-01-01

    The purpose of this study was to assess the diagnostic value of scans with 99 Tc m (V)-dimercaptosuccinic acid (DMSA) to localize bone metastases and to evaluate the capability to diagnose bone/joint infections with scans using 99 Tc m -Citrate. Eighteen patients referred to bone metastases and eighteen patients referred to bone and joint infection were studied. In all patients, a bone scan of 99 Tc m -MDP was obtained initially. Subsequently, comparative scans with 99 Tc m (V)-DMSA and 99 Tc m -Citrate were conducted successively. Pathologic finding and/or microbiological finding, X-ray CT and/or MRI, and/or clinical follow-up (until symptoms disappeared) were considered to be proof of the presence of bone metastases and bone/joint infection. All of the eighteen patients with diagnosed bone metastases and of the eighteen patients with diagnosed bone and joint infection had positive 99 Tc m -MDP scintigraphy. The fifteen patients with diagnosed bone metastases and the fifteen patients with diagnosed bone/joint infection had increased 99 Tc m (V) -DMSA accumulation at certain areas matched with those shown in 99 Tc m -MDP scans, and only one patient with diagnosed bone metastases and the fifteen patients with diagnosed bone and joint infection had increased 99 Tc m -Citrate accumulation at certain areas matched with those shown in 99 Tc m -MDP scans. 99 Tc m -MDP scans show 64 bone lesions in the bone metastases while 49 lesions by the 99 Tc m (V)-DMSA scans and only one lesion by the 99 Tc m -Citrate scans respectively. And 99 Tc m -MDP scans show 22 bone lesions in the bone and joint infection while 17 lesions by the 99 Tc m (V)-DMSA imaging and 16 lesions by the 99 Tc m -Citrate imaging respectively. For bone metastases diagnosis, the sensitivity of 99 Tc m (V)-DMSA imaging and 99 Tc m -Citrate imaging were 76.56% and 1.56%, respectively, and the specificity were only 22.73% and 27.27%, respectively. For bone and joint infection diagnosis, the sensitivity of two

  7. Reliability analysis of a replication with limited number of journaling files

    International Nuclear Information System (INIS)

    Kimura, Mitsutaka; Imaizumi, Mitsuhiro; Nakagawa, Toshio

    2013-01-01

    Recently, replication mechanisms using journaling files have been widely used for the server systems. We have already discussed the model of asynchronous replication system using journaling files [8]. This paper formulates a stochastic model of a server system with replication considering the number of transmitting journaling files. The server updates the storage database and transmits the journaling file when a client requests the data update. The server transmits the database content to a backup site either at a constant time or after a constant number of transmitting journaling files. We derive the expected number of the replication and of transmitting journaling files. Further, we calculate the expected cost and discuss optimal replication interval to minimize it. Finally, numerical examples are given

  8. 18 CFR 39.5 - Reliability Standards.

    Science.gov (United States)

    2010-04-01

    ... 18 Conservation of Power and Water Resources 1 2010-04-01 2010-04-01 false Reliability Standards... RELIABILITY STANDARDS § 39.5 Reliability Standards. (a) The Electric Reliability Organization shall file each Reliability Standard or modification to a Reliability Standard that it proposes to be made effective under...

  9. Combined bone scintigraphy with 99mTc-MDP and 99mTc-ciprofloxacin in differentiation of hip and knee prosthesis aseptic loosening and infection: A preliminary study

    Directory of Open Access Journals (Sweden)

    Pucar Dragan

    2017-01-01

    Full Text Available Background/Aim. Although the number of new primary implantation of hip and knee prostheses every year increases, the rate of failed arthroplasty is nearly the same. The main question is whether it is an aseptic instability or instability caused by infection. The aim of this preliminary study was an attempt with combined 99mTc-ciprofloxacin and 99mTc-methylene diphosphonate (MDP bone scintigraphy to improve diagnostic accuracy in the differentiation of hip and knee prosthesis aseptic loosening and periprosthetic joint infection. Methods. Inclusion criteria of patients for this study were based on suspected periprosthetic joint infection: painful prosthetic joint, restricted joint movements and increased value of erythrocyte sedimentation rate or levels of C-reactive protein. We examined 20 patients with implanted 14 hip and 6 knee prosthesis. All patients also underwent plain radiography of suspected joint. In all patients, three-phase 99mTc-MDP bone scintigraphy was performed. Three to five days after the bone scan, we performed scintigraphy using 99mTc-ciprofloxacin with the calculation of accumulation index. Periprosthetic joint infection was confirmed on the basis of microbiological findings. Results. Periprosthetic joint infection was confirmed in fourteen of twenty observed joints, in five of them the aseptic loosening was present and in one patient’s symptoms were not related to the prosthesis (poor biomechanics of prosthetic joints caused by weaknesses of muscle. Estimated sensitivity/specificity for 99mTc-MDP bone scintigraphy alone were 100/17%; for 99mTc-ciprofloxacin scintigraphy were 85,7/100%. Sensitivity and specificity were 92,3% and 83,3%, respectively for results obtained with combined assessment by both methods. Our study confirmed the high negative predictive value of 99mTc-MDP bone scan. The negative result of bone scan virtually excludes the possibility of periprosthetic infection. On the other hand, positive findings of

  10. Transient diffuse hepatic uptake of 99mTc-MDP after hepatitis B vaccination

    International Nuclear Information System (INIS)

    Kim, Hyun Jin; Park, Young Ha; Hwang, Seong Su; Chung, Soo Kyo; Kim, Sang Heum

    2006-01-01

    A 38-year-old female with arthralgia in right elbow joint for 6 months was referred for a bone scan which showed diffuse uptakes of 99m Tc-MDP in the liver and spleen without hepatosplenomegaly. She had a history of hepatitis B vaccination 3 days ago. These uptakes were disappeared on the follow-up bone scan after 4 months. We suggest this transient diffuse hepatic uptake after vaccination of hepatitis B might be due to aluminum component within the hepatitis B vaccine as adjuvant

  11. Myocardial 99mTc-MDP uptake on the bone scintigraphy in the hemodialysis-associated amyloidosis: a case report

    International Nuclear Information System (INIS)

    Fard Esfahani, A.; Assadi, M.; Eftekhari, M.; Fallahi Sichani, B.; Beiki, D.; Akbarpour, S.; Mohammadian, M.

    2005-01-01

    Amyloidosis is characterized by an abnormal extracellular deposition of amyloid in different organs, where it usually causes some type of dysfunction. Its cause is unknown. Five different types of amyloidosis have been described according to the underlying disease; immunoglobulin amyloidosis, ,familial amyloidosis, senile systemic amyloidosis, secondary amyloidosis and hemodialysis-associated amyloidosis. We report a case of hemodialysis-associated amyloidosis in a 56-year-old man that radionuclide imaging demonstrated intense uptake of Tc-99m MDP within the myocardium. The diagnosis of amyloidosis was established by analysis of aspirated abdominal fat, although other non- invasive modalities didn't reveal any positive findings. The,first clue to the possible presence of amyloidosis in this case was provided by the radionuclide bone scan performed, which revealed intense tracer uptake in the heart suggesting amyloid deposit. We conclude that in cases of extraosseous accumulation of' Tc-99 MDP especially as a diffuse pattern of myocardial uptake, a diagnosis of amyloidosis should be considered, in an appropriate clinical setting

  12. Measurement of 24-hr whole-body retention of Tc-99mMDP with a thyroid uptake probe: quantitative assessment of metabolic and metastatic bone diseases

    International Nuclear Information System (INIS)

    Seto, H.; Futatsuya, R.; Kamei, T.; Furumoto, N.; Ishizaki, Y.; Hada, M.; Kakishita, M.

    1983-01-01

    A new method for measurement of 24-hr whole body retention (WBR) of Tc-99mMDP, using a thyroid uptake probe was established and its clinical significance was evaluated in 102 patients with various bone disorders, including metabolic and metastatic bone diseases, aged above 20 years old. Reproducibility of 24-hr WBR in 10 patients was very good (r=0.996). The 24-hr WBR of Tc-99mMDP in the normal subjects was 30.4 +- 4.6%. The WBR values of chronic renal failure, metastatic bone disease and hyperthyroidism groups were 98.4 +- 3.0, 44.0 +- 8.0, 40,6 +- 6.3% respectively, which were significantly higher (p < 0.001). However the WBR of steroid-induced osteoporotic group was significantly lower (17.3 +- 5.4%) as compared with the normal group (p < 0.001). Based on these results the method is simple, reproducible and accurate to measure 24-hr WBR of Tc-99mMDP. Quantification of WBR is of great clinical value to diagnose metabolic bone disease and to follow-up metabolic and metastatic bone disease after treatment

  13. Evaluation of using 99Tcm-MDP SPECT/CT for differentiating malignancy from benignancy in femoral diseases

    International Nuclear Information System (INIS)

    Ou Xiaohong; Huang Rui; Su Minggang; Zhou Li'na; Fan Qiuping

    2010-01-01

    Objective: To evaluate the value of SPECT/CT in assessment of femoral foci of abnormal bone metabolism classified as intermediated on bone scanning using 99Tcm-methylene diphosphonate (MDP). Methods: There were 94 patients with solitary femoral abnormal uptake in bone scanning included. SPECT was accompanied by inline CT over the femoral region. All of the images were blindly interpreted independently by two experienced board-certified radiologists. The reference standard was follow-up over half a year of MRI, CT, SPECT, or pathology. Diagnosis which consist with reference were counted as accurate. Diagnosis which either not consist with reference or undetermined were counted as false. Results: Of the 94 patients, 78 patients (male 42 , female 36, mean age 62 yrs) have the definite diagnosis of their femoral foci. 19 were proved to be metastasis and the other 59 were benign diseases. The diagnostic accuracy by bone SPECT, bone CT and fusion imaging were 58.9%, 87.2%, 96.2% respectively. Conclusions: Most of the solitary femoral foci caused by benign diseases. SPECT/CT using 99 Tc m -MDP has additional valuable in differentiating malignancy from benignancy in femoral foci . (authors)

  14. sup(99m)Tc-MDP bone scintigraphy: kinetics of captation and differential diagnosis

    International Nuclear Information System (INIS)

    Slosman, D.; Frey, P.; Donath, A.

    1983-01-01

    The differential diagnosis of bone pathology is approached by the study of local MDP kinetics during the first two hours after intravenous injection. The value of the ratio between the pathological and the contralateral side is constant in normal cases (flat curve), it decreases in infectious bone diseases, it passes through a maximum after 1 to 1 1/2 hour in inflammatory non-infectious involvement of bone and it keeps increasing in primary bone pathological conditions. This technique has become a very useful tool in approaching differential diagnosis

  15. (99m)Tc-MDP SPECT/CT as the one-stop imaging modality for the diagnosis of early setting of Kienbock's disease.

    Science.gov (United States)

    Arora, S; Singh Dhull, V; Karunanithi, S; Kumar Parida, G; Sharma, A; Shamim, S A

    2015-01-01

    (99m)Tc-Methylene diphosphonate (MDP) triple phase bone scintigraphy (BS) has a role in early diagnosis of Kienbock's disease, especially when the X-ray is negative. Early diagnosis can result in prompt management of the patient since wrist pain in older individuals due to aging may go unnoticed or be due to other diagnoses with the production of greater damage and eventually a worse prognosis. Herein, we present a case report of a 29-year-old female with Kienbock's disease in whom the X-ray was negative and MRI incorrect. The (99m)Tc-MDP SPECT/CT BS helped the diagnosis of the disease in an early stage (stage 1) and had a clinical impact on the patient's management. Copyright © 2014 Elsevier España, S.L.U. and SEMNIM. All rights reserved.

  16. Quantification of the vascularisation of the orbital implants of coralinehydroxyapatite with {sup 99m} Tc-MDP; Cuantificacion de la vascularizacion de los implantes orbitales dehidroxiapatita coralina con {sup 99m} Tc-MDP

    Energy Technology Data Exchange (ETDEWEB)

    Rodriguez, J.L.; Solano, M.E.; Alvarez, I.; Perez, G. [Centro deInvestigaciones Clinicas 34 no.4501 e/45 y 47 Kohly, Playa C. Habana (Cuba)

    1998-12-31

    The use of ocular implants of hydroxyapatite has been increased in the last times owing to that they are well tolerated by the organism and that on the integration they show good mobility on the artificial eye with very few complications. The gammagraphy with {sup 99m} Tc-MDP can be used for the evaluation of vascularisation and its relative quantification above on these implants. In this pilot essay 10 normal persons and 37 patients were studied who had an implant of Cuban coraline hydroxyapatite (Coraline HAP-200). Thermography with {sup 99m} Tc-MDP was realized between 4 and 18 months after surgery then were obtained plane images in anterior viewing. It was measured the implant vascularisation and it was calculated for each case the relative captivation index (RCI) starting from two regions of ocular interest. As result all patients tolerated the implant without complications. The relation of the activity implant with respect to the contralateral region was 2.31{+-}0.63 (mean {+-} SD) with a range of 1.17-4.09. The relation between the left intra orbital captivation and the right in the normal persons was 1.01 {+-}0.66 (mean {+-} SD). In conclusion, we obtained that the ICR can be very useful in order to measure the integration level of this type of implant.Moreover, it was proved that the implants with Cuban coraline hydroxyapatite showed an acceptable level of integration in all the patients. (Author)

  17. 12 CFR 19.10 - Filing of papers.

    Science.gov (United States)

    2010-01-01

    ... 12 Banks and Banking 1 2010-01-01 2010-01-01 false Filing of papers. 19.10 Section 19.10 Banks and... Rules of Practice and Procedure § 19.10 Filing of papers. (a) Filing. Any papers required to be filed...) Delivering the papers to a reliable commercial courier service, overnight delivery service, or to the U.S...

  18. 12 CFR 747.10 - Filing of papers.

    Science.gov (United States)

    2010-01-01

    ... 12 Banks and Banking 6 2010-01-01 2010-01-01 false Filing of papers. 747.10 Section 747.10 Banks... Practice and Procedure § 747.10 Filing of papers. (a) Filing. Any papers required to be filed, excluding...) Delivering the papers to a reliable commercial courier service, overnight delivery service, or to the U.S...

  19. Intense muscle uptake of Ga-67 citrate and Tc-99m MDP in a patient with aplastic anemia

    International Nuclear Information System (INIS)

    Batte, W.G. Jr.; Yeh, S.D.; Rosenblum, M.K.; Larson, S.M.

    1991-01-01

    An unusual distribution of Tc-99m MDP and Ga-67 citrate in several muscle groups is described in a 14-year-old boy with aplastic anemia and normal renal function at the time of imaging. Although the patient did not develop musculo-skeletal signs or symptoms, a subsequent autopsy revealed widespread muscle calcification

  20. Facial osteomyelitis as complication of chronic sinusitis in hemophiliac-AIDS patients - scintigraphic evaluation with technetium-99m-MDP and Gallium-67; Osteomielitis da face como complicacao de sinusite cronica em hemofilicos aideticos - avaliacao cintilografica com {sup 99m} Tc-MDP e {sup 67} Ga

    Energy Technology Data Exchange (ETDEWEB)

    Marques, Marise da Penha Costa [Universidade Federal, Rio de Janeiro, RJ (Brazil). Faculdade de Medicina. Dept. de Otorrinolaringologia e Oftalmologia; Wolosker, Sara [Universidade Federal, Rio de Janeiro, RJ (Brazil). Faculdade de Medicina. Dept. de Radiologia; Marchiori, Edson [Universidade Federal Fluminense, Niteroi, RJ (Brazil). Dept. de Radiologia

    1997-01-01

    In the paper six cases of facial osteomyelitis as a complication of chronic sinusitis in hemophiliac-AIDS patients are reported. Osteomyelitis was suggested by an increasing of erythrocyte sedimentation rate. The diagnosis was confirmed by a positive {sup 99m} Tc MDP scintigraphy. The patients were submitted to clinical treatment. The erythrocyte sedimentation rate and 67-gallium citrate scans were used in the follow-up of the therapy. Three patients had negative gallium after three weeks of organism-specific antibiotic therapy; in two patients the gallium scintigraphy remained positive. One patient did not undergo the radionuclide scan for this clinical conditions. These results suggest that MDP scans showed higher sensitivity and specificity in detection of bone disease in chronic sinusitis. Gallium scans appeared to be valuable tool in the follow-up of the infection. There are no reports in the literature of osteomyelitis as a complication of chronic sinusitis in AIDS patient. (author) 43 refs., 4 figs.

  1. 99m technetium-MDP bone scintigraphy in evaluation of painful joint prosthesis

    International Nuclear Information System (INIS)

    Milosevic, D.; Jaukovic, M.; Jaukovic, Lj.; Ajdinovic, B.

    2004-01-01

    In addition of clinical evaluation and x-ray radiography, the diagnosis of a loose joint prosthesis is often made by nuclear medicine imaging techniques. Differentiation between loosening and infected prosthesis is important for better treatment of those patients. Aim: The aim of this study was to reevaluate the scintigraphic patterns in patients with painful hip of knee arthroplasty. Material and Method: From 1996. to 2003. forty patients aged 49-78 years were referred for evaluation of possible loosening/infection joint prosthesis: 36 pts with 39 total/ partial hip prosthesis, 1 pt with knee prosthesis and 3 pts with history of previously extracted hip prosthesis due to infection. Whole body acquisition had been performed with a single head gamma camera three hours after the injection of 740 MBq 99m Tc-MDP. Scans were classified as: positive for loosening if abnormal uptake was shown at the tip of the prosthesis; positive for infection if diffuse abnormal uptake was shown around the implant; negative and indeterminate scans. Scintigraphic findings were compared to clinical follow up, histology or cultures. Results: Positive findings were found in 17 bone scans strongly suggesting loosening in 10 cases, infection of prosthesis in 4 cases and both loosening/infection in 3 cases. Bone scintigraphy was normal in 11pts. Scans of three pts with previously extracted hip prosthesis and scheduled for reimplatation, showed inhomogeneously and mildly increased uptake in femur. Most of scans classified as indeterminate (n=12) showed slightly increased tracer uptake in region of acetabular roof, greater or lesser tho chanter, suggesting bone remodeling due to the presence of implant, rather than loosening. Conclusion: 99m Tc-MDP bone scintigraphy had a significant role in assessing the painful joint prosthesis. Complementary diagnostic procedures should be considered in indeterminate scintiscans. (authors)

  2. DIRAC: reliable data management for LHCb

    International Nuclear Information System (INIS)

    Smith, A C; Tsaregorodtsev, A

    2008-01-01

    DIRAC, LHCb's Grid Workload and Data Management System, utilizes WLCG resources and middleware components to perform distributed computing tasks satisfying LHCb's Computing Model. The Data Management System (DMS) handles data transfer and data access within LHCb. Its scope ranges from the output of the LHCb Online system to Grid-enabled storage for all data types. It supports metadata for these files in replica and bookkeeping catalogues, allowing dataset selection and localization. The DMS controls the movement of files in a redundant fashion whilst providing utilities for accessing all metadata. To do these tasks effectively the DMS requires complete self integrity between its components and external physical storage. The DMS provides highly redundant management of all LHCb data to leverage available storage resources and to manage transient errors in underlying services. It provides data driven and reliable distribution of files as well as reliable job output upload, utilizing VO Boxes at LHCb Tier1 sites to prevent data loss. This paper presents several examples of mechanisms implemented in the DMS to increase reliability, availability and integrity, highlighting successful design choices and limitations discovered

  3. Quantification of the vascularisation of the orbital implants of coralinehydroxyapatite with 99m Tc-MDP

    International Nuclear Information System (INIS)

    Rodriguez, J.L.; Solano, M.E.; Alvarez, I.; Perez, G.

    1998-01-01

    The use of ocular implants of hydroxyapatite has been increased in the last times owing to that they are well tolerated by the organism and that on the integration they show good mobility on the artificial eye with very few complications. The gammagraphy with 99m Tc-MDP can be used for the evaluation of vascularisation and its relative quantification above on these implants. In this pilot essay 10 normal persons and 37 patients were studied who had an implant of Cuban coraline hydroxyapatite (Coraline HAP-200). Thermography with 99m Tc-MDP was realized between 4 and 18 months after surgery then were obtained plane images in anterior viewing. It was measured the implant vascularisation and it was calculated for each case the relative captivation index (RCI) starting from two regions of ocular interest. As result all patients tolerated the implant without complications. The relation of the activity implant with respect to the contralateral region was 2.31±0.63 (mean ± SD) with a range of 1.17-4.09. The relation between the left intra orbital captivation and the right in the normal persons was 1.01 ±0.66 (mean ± SD). In conclusion, we obtained that the ICR can be very useful in order to measure the integration level of this type of implant.Moreover, it was proved that the implants with Cuban coraline hydroxyapatite showed an acceptable level of integration in all the patients. (Author)

  4. Facial osteomyelitis as complication of chronic sinusitis in hemophiliac-AIDS patients - scintigraphic evaluation with technetium-99m-MDP and Gallium-67

    International Nuclear Information System (INIS)

    Marques, Marise da Penha Costa; Wolosker, Sara; Marchiori, Edson

    1997-01-01

    In the paper six cases of facial osteomyelitis as a complication of chronic sinusitis in hemophiliac-AIDS patients are reported. Osteomyelitis was suggested by an increasing of erythrocyte sedimentation rate. The diagnosis was confirmed by a positive 99m Tc MDP scintigraphy. The patients were submitted to clinical treatment. The erythrocyte sedimentation rate and 67-gallium citrate scans were used in the follow-up of the therapy. Three patients had negative gallium after three weeks of organism-specific antibiotic therapy; in two patients the gallium scintigraphy remained positive. One patient did not undergo the radionuclide scan for this clinical conditions. These results suggest that MDP scans showed higher sensitivity and specificity in detection of bone disease in chronic sinusitis. Gallium scans appeared to be valuable tool in the follow-up of the infection. There are no reports in the literature of osteomyelitis as a complication of chronic sinusitis in AIDS patient. (author)

  5. 78 FR 64488 - Combined Notice of Filings #1

    Science.gov (United States)

    2013-10-29

    ... Numbers: ER13-585-000. Applicants: New England Power Pool Participants Committee, ISO New England Inc... Pool, Inc. Description: Removal of NERCs Administration of Reliability-Grid Management Tools to be... qualifying facilities filings can be found at: http://www.ferc.gov/docs-filing/efiling/filing-req.pdf . For...

  6. 77 FR 33206 - Combined Notice of Filings #1

    Science.gov (United States)

    2012-06-05

    ... Reliability Standard CIP- 006--Cyber Security--Physical Security of Critical Cyber Assets. Filed Date: 5/23/12... Commission received the following electric securities filings: Docket Numbers: ES12-31-000. Applicants...

  7. Pengembangan SMS Gateway Layanan Informasi Akademik di STMIK GI MDP

    Directory of Open Access Journals (Sweden)

    Fransiska Prihatini Sihotang

    2017-08-01

    Full Text Available Information technology can be utilized in education such as e-Learning and Academic Information System. STMIK GI MDP has applied information technology that provides ease for the dissemination of academic information to students. However, the parents of the students have not obtained the academic information of their children due to the lack of internet-related knowledge. Therefore, this study aims to create a service that is able to convey information to parents directly with SMS Gateway service. This research begins with the collection of user needs through observation techniques and interviews to academic staff and parents. Then performed the required feature analysis. Then the design of SMS Gateway application that will be embedded in existing academic applications and coding system. Gammu is used as a link between applications with mobile phones. The result of this research is the application of SMS Gateway service that can give the student academic information to the parents.

  8. A Metadata-Rich File System

    Energy Technology Data Exchange (ETDEWEB)

    Ames, S; Gokhale, M B; Maltzahn, C

    2009-01-07

    Despite continual improvements in the performance and reliability of large scale file systems, the management of file system metadata has changed little in the past decade. The mismatch between the size and complexity of large scale data stores and their ability to organize and query their metadata has led to a de facto standard in which raw data is stored in traditional file systems, while related, application-specific metadata is stored in relational databases. This separation of data and metadata requires considerable effort to maintain consistency and can result in complex, slow, and inflexible system operation. To address these problems, we have developed the Quasar File System (QFS), a metadata-rich file system in which files, metadata, and file relationships are all first class objects. In contrast to hierarchical file systems and relational databases, QFS defines a graph data model composed of files and their relationships. QFS includes Quasar, an XPATH-extended query language for searching the file system. Results from our QFS prototype show the effectiveness of this approach. Compared to the defacto standard, the QFS prototype shows superior ingest performance and comparable query performance on user metadata-intensive operations and superior performance on normal file metadata operations.

  9. Emotion model of interactive virtual humans on the basis of MDP

    Institute of Scientific and Technical Information of China (English)

    WANG Guojiang; WANG Zhiliang; TENG Shaodong; XIE Yinggang; WANG Yujie

    2007-01-01

    Emotion plays an essential role in the adaptation and social communication of organisms.Similarly,an appropriately timed and clearly expressed emotion is a central requirement for believable interactive virtual humans.Presently,incorporating emotion into virtual humans has gained increasing attention in the academia and industry.This strong interest is driven by a wide spectrum of promising applications in many areas such as virtual reality,e-learning,entertainment,etc.This paper introduces an emotion model of artificial psychology,in which the transition of emotion can be viewed as a Markov process and the relation of emotion,external incentive and personality can be described by a Markov decision process (MDP).In order to demonstrate the approach,this paper integrates the emotion model into a system composed of voice recognition and a realistic facial model.Thus,the model could be used for generating a variety of emotional expressions of autonomous,interactive virtual human beings.

  10. Sup (99m) Tc-MDP accumulation and absence of concentration of sup (99m) Tc-sulfur colloid in the spleen

    International Nuclear Information System (INIS)

    Calegaro, J.U.M.; Carvalho, A.C.M. de; Ulyssea, R.

    1984-01-01

    A case of a nine years old girl with sickle cell anemia, that showed splenic accumulation of sup (99m) Tc-MDP during bone scintigraphy is reported. On the other side, the scan with sup (99m) Tc-sulfur colloid showed no uptake in the spleen. These findings are discussed with a brief review of the pertinent literature. (Author) [pt

  11. DIRAC reliable data management for LHCb

    CERN Document Server

    Smith, A C

    2008-01-01

    DIRAC, LHCb's Grid Workload and Data Management System, utilizes WLCG resources and middleware components to perform distributed computing tasks satisfying LHCb's Computing Model. The Data Management System (DMS) handles data transfer and data access within LHCb. Its scope ranges from the output of the LHCb Online system to Grid-enabled storage for all data types. It supports metadata for these files in replica and bookkeeping catalogues, allowing dataset selection and localization. The DMS controls the movement of files in a redundant fashion whilst providing utilities for accessing all metadata. To do these tasks effectively the DMS requires complete self integrity between its components and external physical storage. The DMS provides highly redundant management of all LHCb data to leverage available storage resources and to manage transient errors in underlying services. It provides data driven and reliable distribution of files as well as reliable job output upload, utilizing VO Boxes at LHCb Tier1 sites ...

  12. Deceit: A flexible distributed file system

    Science.gov (United States)

    Siegel, Alex; Birman, Kenneth; Marzullo, Keith

    1989-01-01

    Deceit, a distributed file system (DFS) being developed at Cornell, focuses on flexible file semantics in relation to efficiency, scalability, and reliability. Deceit servers are interchangeable and collectively provide the illusion of a single, large server machine to any clients of the Deceit service. Non-volatile replicas of each file are stored on a subset of the file servers. The user is able to set parameters on a file to achieve different levels of availability, performance, and one-copy serializability. Deceit also supports a file version control mechanism. In contrast with many recent DFS efforts, Deceit can behave like a plain Sun Network File System (NFS) server and can be used by any NFS client without modifying any client software. The current Deceit prototype uses the ISIS Distributed Programming Environment for all communication and process group management, an approach that reduces system complexity and increases system robustness.

  13. 78 FR 19699 - Combined Notice of Filings #1

    Science.gov (United States)

    2013-04-02

    ..., L.P., Erie Boulevard Hydropower, L.P., FPL Energy Maine Hydro, LLC, Granite Reliable Power, LLC... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission Combined Notice of Filings 1 Take notice that the Commission received the following electric corporate filings: Docket Numbers: EC13-84-000...

  14. HiRel: Hybrid Automated Reliability Predictor (HARP) integrated reliability tool system, (version 7.0). Volume 4: HARP Output (HARPO) graphics display user's guide

    Science.gov (United States)

    Sproles, Darrell W.; Bavuso, Salvatore J.

    1994-01-01

    The Hybrid Automated Reliability Predictor (HARP) integrated Reliability (HiRel) tool system for reliability/availability prediction offers a toolbox of integrated reliability/availability programs that can be used to customize the user's application in a workstation or nonworkstation environment. HiRel consists of interactive graphical input/output programs and four reliability/availability modeling engines that provide analytical and simulative solutions to a wide host of highly reliable fault-tolerant system architectures and is also applicable to electronic systems in general. The tool system was designed at the outset to be compatible with most computing platforms and operating systems and some programs have been beta tested within the aerospace community for over 8 years. This document is a user's guide for the HiRel graphical postprocessor program HARPO (HARP Output). HARPO reads ASCII files generated by HARP. It provides an interactive plotting capability that can be used to display alternate model data for trade-off analyses. File data can also be imported to other commercial software programs.

  15. JENDL Dosimetry File

    International Nuclear Information System (INIS)

    Nakazawa, Masaharu; Iguchi, Tetsuo; Kobayashi, Katsuhei; Iwasaki, Shin; Sakurai, Kiyoshi; Ikeda, Yujiro; Nakagawa, Tsuneo.

    1992-03-01

    The JENDL Dosimetry File based on JENDL-3 was compiled and integral tests of cross section data were performed by the Dosimetry Integral Test Working Group of the Japanese Nuclear Data Committee. Data stored in the JENDL Dosimetry File are the cross sections and their covariance data for 61 reactions. The cross sections were mainly taken from JENDL-3 and the covariances from IRDF-85. For some reactions, data were adopted from other evaluated data files. The data are given in the neutron energy region below 20 MeV in both of point-wise and group-wise files in the ENDF-5 format. In order to confirm reliability of the data, several integral tests were carried out; comparison with the data in IRDF-85 and average cross sections measured in fission neutron fields, fast reactor spectra, DT neutron fields and Li(d, n) neutron fields. As a result, it has been found that the JENDL Dosimetry File gives better results than IRDF-85 but there are some problems to be improved in future. The contents of the JENDL Dosimetry File and the results of the integral tests are described in this report. All of the dosimetry cross sections are shown in a graphical form. (author) 76 refs

  16. JENDL Dosimetry File

    Energy Technology Data Exchange (ETDEWEB)

    Nakazawa, Masaharu; Iguchi, Tetsuo [Tokyo Univ. (Japan). Faculty of Engineering; Kobayashi, Katsuhei [Kyoto Univ., Kumatori, Osaka (Japan). Research Reactor Inst.; Iwasaki, Shin [Tohoku Univ., Sendai (Japan). Faculty of Engineering; Sakurai, Kiyoshi; Ikeda, Yujior; Nakagawa, Tsuneo [Japan Atomic Energy Research Inst., Tokai, Ibaraki (Japan). Tokai Research Establishment

    1992-03-15

    The JENDL Dosimetry File based on JENDL-3 was compiled and integral tests of cross section data were performed by the Dosimetry Integral Test Working Group of the Japanese Nuclear Data Committee. Data stored in the JENDL Dosimetry File are the cross sections and their covariance data for 61 reactions. The cross sections were mainly taken from JENDL-3 and the covariances from IRDF-85. For some reactions, data were adopted from other evaluated data files. The data are given in the neutron energy region below 20 MeV in both of point-wise and group-wise files in the ENDF-5 format. In order to confirm reliability of the data, several integral tests were carried out; comparison with the data in IRDF-85 and average cross sections measured in fission neutron fields, fast reactor spectra, DT neutron fields and Li(d,n) neutron fields. As a result, it has been found that the JENDL Dosimetry File gives better results than IRDF-85 but there are some problems to be improved in future. The contents of the JENDL Dosimetry File and the results of the integral tests are described in this report. All of the dosimetry cross sections are shown in a graphical form.

  17. 77 FR 57563 - Combined Notice Of Filings #1

    Science.gov (United States)

    2012-09-18

    .... Applicants: New York Independent System Operator, Inc., Niagara Mohawk Power Corporation. Description.... Take notice that the Commission received the following electric reliability filings: Docket Numbers: RR12-13-000. Applicants: North American Electric Reliability Corporation. Description: Update to...

  18. The biomechanics study of rabbit osteoporosis models treated by 99Tcm-MDP combined with GuKangLing

    International Nuclear Information System (INIS)

    Gao Kejia; Zhao Guoding; Ye Zhiwei; Mei Xiaogang; Tian Yingmin; Yan Chushun; Wang Wei; Li Wei; Cai Zhengyu; Song Haiping

    2011-01-01

    Objective: To study the bone biomechanics of the rabbit osteoporosis models induced by dexamethasone sodium phosphate injection (DX) using a combined treatment modality of 99 Tc-MDP and GuKangLing. Methods: Rabbits were intramuscularly injected with DX (2 mg/kg) twice a week for 6 weeks. The animal osteoporosis model group (Group C) and normal group (Group A) were compared to confirm the model was available. Another control group (Group B), the osteoporosis control group (Group D) were set for the comparison at the end of the experiment. The 99 Tc-MDP therapy group (Group E), GuKangLing therapy group (Group F) and 99 Tc-MDP plus GuKangLing therapy group (Group G) were included in the study. The treatment lasted for 16 weeks. The bone biomechanics, cytopathology bone histomorphology, bone mineral density (BMD), X-ray, CT, bone scintigraphy and serum bone alkaline phosphatase (BALP) and P (bone gla protein) were chosen as the markers or methods to evaluate the treatment results (excellent, effective and invalid). The analysis of variance (ANOVA) and t-test were used for group comparison analysis. Results: Cytopathology result indicated that there was no bone trabecular destruction in Group A. However, there was distinct bone destruction in Group C. The bone biomechanics (left femur head (265.914 ±52.773) N, L 4 (369.671 ±94.919) N), BMD (left femur (0.238 ±0.016) g/cm 2 , L 4 (0.236 ±0.016) g/cm 2 ) and bone histomorphology ((66.230 ± 10.848)%) in Group C reduced clearly as compared with Group A ((405.343±55.410) N, (750.870±53.718) N, (0.294±0.017) g/cm 2 , (0.302±0.023) g/cm 2 , (131.500 ± 21.846)%) (t ≥4.550, all P<0.01). Radionuclide bone scan also showed that the uptake of tracers was higher by the main arthrosis in Group C than that in Group A. Vertebra was not clearly visualized on bone scan image. There were significant differences between Group A and Group C in serum BALP and P ((45.000±7.303) vs (12.485 ±1.512) U/L, (0.168±0.018) vs (0.115

  19. DJFS: Providing Highly Reliable and High‐Performance File System with Small‐Sized

    Directory of Open Access Journals (Sweden)

    Junghoon Kim

    2017-11-01

    Full Text Available File systems and applications try to implement their own update protocols to guarantee data consistency, which is one of the most crucial aspects of computing systems. However, we found that the storage devices are substantially under‐utilized when preserving data consistency because they generate massive storage write traffic with many disk cache flush operations and force‐unit‐access (FUA commands. In this paper, we present DJFS (Delta‐Journaling File System that provides both a high level of performance and data consistency for different applications. We made three technical contributions to achieve our goal. First, to remove all storage accesses with disk cache flush operations and FUA commands, DJFS uses small‐sized NVRAM for a file system journal. Second, to reduce the access latency and space requirements of NVRAM, DJFS attempts to journal compress the differences in the modified blocks. Finally, to relieve explicit checkpointing overhead, DJFS aggressively reflects the checkpoint transactions to file system area in the unit of the specified region. Our evaluation on TPC‐C SQLite benchmark shows that, using our novel optimization schemes, DJFS outperforms Ext4 by up to 64.2 times with only 128 MB of NVRAM.

  20. CADRIGS--computer aided design reliability interactive graphics system

    International Nuclear Information System (INIS)

    Kwik, R.J.; Polizzi, L.M.; Sticco, S.; Gerrard, P.B.; Yeater, M.L.; Hockenbury, R.W.; Phillips, M.A.

    1982-01-01

    An integrated reliability analysis program combining graphic representation of fault trees, automated data base loadings and reference, and automated construction of reliability code input files was developed. The functional specifications for CADRIGS, the computer aided design reliability interactive graphics system, are presented. Previously developed fault tree segments used in auxiliary feedwater system safety analysis were constructed on CADRIGS and, when combined, yielded results identical to those resulting from manual input to the same reliability codes

  1. Current advances in mechanical design and production VII: proceedings of the Seventh Cairo University International MDP Conference ; Cairo-Egypt, February 15-17, 2000

    National Research Council Canada - National Science Library

    Megahed, Säıd M; Hassan, Mohamed F

    2000-01-01

    ... with keynote papers to enrich the sessions and to highlight the recent advances on the various fields of mechanical design and production. A total of 160 papers were submitted to MDP-7 conference from more than 21 countries from the 6 continents. All papers were thoroughly refereed by the conference scientific committee. Following the reviewing proces...

  2. High HIV prevalence and incidence among women in Southern Mozambique: Evidence from the MDP microbicide feasibility study.

    Directory of Open Access Journals (Sweden)

    Sibone Mocumbi

    Full Text Available The study aimed to assess the feasibility of conducting large scale HIV prevention clinical trials in Mozambique by measuring HIV prevalence and incidence among women of reproductive age. This paper describes the baseline socio-demographic characteristics of the Mozambique Microbicides Development Programme (MDP feasibility cohort, baseline prevalence of HIV and other STIs, and HIV incidence.The Mozambique MDP feasibility study was conducted from September 2007 to August 2009 in urban Mavalane and rural Manhiça, in Southern Mozambique. Sexually active, HIV negative women aged 18 years and above were recruited to attend the study clinic every 4 weeks for a total of 40 weeks. At baseline, we collected demographic and sexual behaviour data, samples to test for sexually transmitted infections (STI and conducted HIV rapid testing. STI and HIV testing were repeated at clinical follow-up visits. We describe HIV prevalence of women at screening, the demographic, behavioural and clinical characteristics of women at enrolment, and HIV incidence during follow-up.We screened 793 women (369 at Mavalane and 424 at Manhiça and enrolled 505 eligible women (254 at Mavalane and 251 at Manhiça. Overall HIV prevalence at screening was 17%; 10% at Mavalane and 22% at Manhiça. Women screened at Manhiça were twice as likely as women screened at Mavalane to be HIV positive and HIV positive status was associated with younger age (18-34, lower educational level, not using a reliable method of contraception and being Zionist compared to other Christian religions. At enrolment contraceptive use was low in both clinics at 19% in Mavalane and 21% in Manhiça, as was reported condom use at last sex act at 48% in Mavalane and 25% in Manhiça. At enrolment, 8% of women tested positive for Trichomonas vaginalis, 2% for Neisseria gonorrhoeae, 4% for Chlamydia trachomatis and 46% for bacterial vaginosis. In Manhiça, 8% of women had active syphilis at screening. HIV incidence

  3. Administered activity optimization in skeletal scanning using MDP labeled 99Tcm

    International Nuclear Information System (INIS)

    Perez Diaz, Marlen; Quevedo Garcia, Jose; Diaz Rizo, Oscar; Dopico Hernandez, Rolando; Estevez Aparicio, Eric; Viamonte Marin, Alfredo; Cabrera Gorrin, Orlando

    2002-01-01

    The objective of this study was to determine the minimum activity of the MDP labeled 99Tcm which is able to produce both, good image quality in the gamma camera and better radiological protection for the patient. Four samples of 18 patients were taken. A different protocol was applied to each sample. Each sample was divided into 3 groups of 6 patients each. The activity applied to each group was 293 MBq, 430 MBq and 598 MBq. Each study had 5 images to be assessed by expert criterion: Left Side Skull, Fore Thorax, Dorsal-cervix Column, Dorsal-lumbar Column and Rear Pelvis. The Number and Rate of Counts, the Signal/Background (S/B) ratio and the patient's sizes were taken as variables for analysis. S/B ratio was the only parameter able to construct a discriminant function of the image quality. Significant difference between the image quality with 598 MBq and 430 MBq (p=0,03) were not detected. The value of 430 MBq is enough to achieve good image quality with Protocol 4 for all the images except for the skull (Au)

  4. Metastatic superscan on 99mTc-MDP bone scintigraphy in a case of carcinoma colon: Common finding but rare etiology

    International Nuclear Information System (INIS)

    Chakraborty, Partha Sarathi; Sharma, Punit; Karunanithi, Sellam; Bal, Chandrasekhar; Kumar, Rakesh

    2014-01-01

    Bone scintigraphy in which there is excessive skeletal radioisotope uptake in relation to soft tissues along with absent or faint activity in the genitourinary tract is known as a ‘superscan’. Prostate cancer is the most common malignancy associated with superscan along with others such as lung cancer, breast cancer and haematological malignancies. Here we present the case of a 41 year old woman with carcinoma colon with metastatic superscan on 99m Tc-MDP bone scintigraphy, a very rare cause for metastatic superscan

  5. Tc-99m-MDP scintigraphy in the evaluation of epidermal nevus syndrome

    International Nuclear Information System (INIS)

    Barbosa, M.N.S.; Cunha, M.O.; Severiche, A.F.A.; Ramos, C.D.; Etchebehere, E.C.S.C.; Belangero, W.; Camargo, E.E.

    1997-01-01

    Full text: Epidermal nevus syndrome has been described as a congenital neurocutaneous disorder in which epidermal nevi are associated with malformations of other organs, commonly the skeleton and central nervous system. Ocular, cardiac, and genitourinary system abnormalities, as well as other skin lesions, may also be seen. A 19 year old patient with epidermal nevus syndrome, presenting congenital facial epidermal nevi and bone deformity of the lower limbs (shortening of the left leg, left thigh varum, bilateral genu valgum, and multiple pathological fractures), as referred to the nuclear medicine laboratory to evaluate involvement of other sites of the skeleton. Whole body bone scintigraphy performed with MDP-Tc-99m showed multiple small focal areas of increased uptake in the skeleton, mainly in the upper and lower limbs, posterior ribs, right acetabulum, right sacroiliac joint, and right greater trochanter, interpreted as pathological fractures at different stages of remodeling. The range of skeletal findings in this condition is quite diverse. Many of these findings can be attributed to local tissue overgrowth with deformities and advanced bone age, associate with pathological fractures

  6. Kwaabana: File sharing for rural networks

    CSIR Research Space (South Africa)

    Johnson, DL

    2013-12-01

    Full Text Available , Zambia. The results show that our localized file sharing service facilitates reliable sharing amongst rural users. Importantly, it also removes the cost barrier present for similar Internet-based services. We outline the process used by Kwaabana...

  7. Administered activity optimization of the MDP labeled with Tc-99 m in bone tip studies

    International Nuclear Information System (INIS)

    Perez Diaz, Marlen; Esteves Aparicio, Eric; Dopico Hernandez, Rolando; Gorrin, Orlando Cabrera

    2003-01-01

    The aim of the present study was to determine the optimum activity of the Cuban MDP labeled with Tc-99 m, for establishing a compromise relation between image quality and patient radiological protection in Nuclear Medicine studies. The used statistical technique was the discriminant analysis to arrive at the optimization criterion. Three samples of 18 patients each were selected. Each sample was undergone to a different acquisition protocol. Each sample was divided into three groups of 6 patients each. The administered activities were: 293 MBq, 430 MBq or 598 MBq. Images of hands and femurs were graded for each study. The ratios Signal /Background and Signal/ Noise were processed. The value of 430 MBq was enough to obtain good image quality using a protocol of 10 minutes of acquisition for the used technical conditions. (author)

  8. Design and Implementation of a Metadata-rich File System

    Energy Technology Data Exchange (ETDEWEB)

    Ames, S; Gokhale, M B; Maltzahn, C

    2010-01-19

    Despite continual improvements in the performance and reliability of large scale file systems, the management of user-defined file system metadata has changed little in the past decade. The mismatch between the size and complexity of large scale data stores and their ability to organize and query their metadata has led to a de facto standard in which raw data is stored in traditional file systems, while related, application-specific metadata is stored in relational databases. This separation of data and semantic metadata requires considerable effort to maintain consistency and can result in complex, slow, and inflexible system operation. To address these problems, we have developed the Quasar File System (QFS), a metadata-rich file system in which files, user-defined attributes, and file relationships are all first class objects. In contrast to hierarchical file systems and relational databases, QFS defines a graph data model composed of files and their relationships. QFS incorporates Quasar, an XPATH-extended query language for searching the file system. Results from our QFS prototype show the effectiveness of this approach. Compared to the de facto standard, the QFS prototype shows superior ingest performance and comparable query performance on user metadata-intensive operations and superior performance on normal file metadata operations.

  9. 77 FR 53884 - Automatic Underfrequency Load Shedding and Load Shedding Plans Reliability Standards; Notice of...

    Science.gov (United States)

    2012-09-04

    ... Underfrequency Load Shedding and Load Shedding Plans Reliability Standards; Notice of Compliance Filing Take notice that on August 9, 2012, North American Electric Reliability Corporation submitted a compliance... Load Shedding Plans Reliability Standards, 139 FERC ] 61,098, (Order No. 763) (2012). Any person...

  10. Value of scintiscanning using 99mTc-MDP to assess disorders of the knee and ankle joints in orthopedic patients as compared to that of X-ray procedures. Die Wertigkeit der Scintigraphie mit 99m Tc-MDP bei Knie- und Fussgelenksaffektionen des orthopaedischen Krankenguts im Vergleich zur Roentgendiagnostik

    Energy Technology Data Exchange (ETDEWEB)

    Buyer, B.

    1983-10-20

    Relevant analyses were carried out on the basis of the data of 100 patients. The radiopharmaceutical examinations were performed using a scanner two hours after injection of 10 mCi 99mTc-MDP. Following interpretation of the density patterns, the concentration quotients of the scintiscans were calculated to permit a semi-quantitative assessment to be made. As far as arthropathies were concerned, the scintiscans did not contribute much useful information to diagnose patellar chondropathy at an early stage of the disease, nor were they seen to offer any decisive advantages over X-ray examinations in degenerative disorders of the joints. Scintiscanning was also found an unsuitable method to differentiate athritis from arthrosis. Under certain circumstances, joint scintiscanning may have an additional indication in the diagnosis of meniscitis. In rheumatoid arthritis and Sudeck's syndrome the scintiscans were found to be in better agreement with the clinical symptoms than the corresponding X-ray findings. In soft tissue disorders scintiscanning did not appear to be an adequate method to obtain additional diagnostic information. On the other hand, all types of osteopathy caused by inflammation, necrosis, neoplasms or cysts are clearly falling within the domaine of scintiscanning. Foot deformities were invariably seen to be associated with locallised concentration of the tracer substance. Owing to the limited specifity of radiopharmaceutical investigations using 99mTc-MDP, concentional X-ray examinations will indispensable in the vast majority of cases. (TRV).

  11. Development of an integrated filing system for endoscopic images.

    Science.gov (United States)

    Fujino, M A; Ikeda, M; Yamamoto, Y; Kinose, T; Tachikawa, H; Morozumi, A; Sano, S; Kojima, Y; Nakamura, T; Kawai, T

    1991-01-01

    A new integrated filing system for endoscopic images has been developed, comprising a main image filing system and subsystems located at different stations. A hybrid filing system made up of both digital and analog filing devices was introduced to construct this system that combines the merits of the two filing methods. Each subsystem provided with a video processor, is equipped with a digital filing device, and routine images were recorded in the analog image filing device of the main system. The use of a multi-input adapter enabled simultaneous input of analog images from up to 8 video processors. Recorded magneto-optical disks make it possible to recall the digital images at any station in the hospital; the disks are copied without image degradation and also utilised for image processing. This system promises reliable storage and integrated, efficient management of endoscopic information. It also costs less to install than the so-called PACS (picture archiving and communication system), which connects all the stations of the hospital using optical fiber cables.

  12. Administered activity of Tc-99m MDP for bone scintigraphy, standard or individual dosage?

    International Nuclear Information System (INIS)

    Vestergren, E.; Gretarsdottir, J.; Jacobsson, L.

    2002-01-01

    Background and Aim: Adult patients are generally, irrespective of size, given the same amount of activity for a certain type of nuclear medicine examination, a standard dosage. Identical image quality is essential when comparing different patient studies. The aim of this study is to evaluate different dosage methods for Tc-99m-MDP bone scintigraphy and to investigate whether individual dosage will decrease the variations in image quality between different patients. Material and Methods: 100 consecutive adult patients (aged between 40 and 89 years) undergoing whole body bone scintigraphy were studied. Eight patients were excluded from the study because of abnormal high uptake in the areas of interest. The patient weight and height were registered. The activity in the syringes was measured before and after the injection of about 600 MBq Tc-99m MDP. Scanning was performed, with a dual head gamma camera (Maxxus or Millennium VG, General Electric) equipped with a high-resolution collimator, at approximately 4 hours (mean 3.8 h) post-injection. Regions of interest (ROI) were drawn over the lumbar spine (posterior view), the right femur (anterior view) and also soft tissue background regions for each area. The total counts, maximum counts/pixel and number of pixels in the ROIs were registered. The maximum number of counts/pixel (background-subtracted), SPINEmax and FEMURmax were chosen as the image quality parameters. For each patient, SPINEmax and FEMURmax where recalculated to the number that would have been obtained with standard dosage (exactly 600 MBq), and dosage proportional to body weight, body surface area and body height. All values were corrected to a scanning time 3.8 h after injection. Results: Both with a standard activity dosage and a dosage proportional to body height, SPINEmax decreases with increasing body weight. Dosage proportional to body weight gives increasing values of SPINEmax with increasing body weight. Dosage proportional to body surface area

  13. Catching errors with patient-specific pretreatment machine log file analysis.

    Science.gov (United States)

    Rangaraj, Dharanipathy; Zhu, Mingyao; Yang, Deshan; Palaniswaamy, Geethpriya; Yaddanapudi, Sridhar; Wooten, Omar H; Brame, Scott; Mutic, Sasa

    2013-01-01

    A robust, efficient, and reliable quality assurance (QA) process is highly desired for modern external beam radiation therapy treatments. Here, we report the results of a semiautomatic, pretreatment, patient-specific QA process based on dynamic machine log file analysis clinically implemented for intensity modulated radiation therapy (IMRT) treatments delivered by high energy linear accelerators (Varian 2100/2300 EX, Trilogy, iX-D, Varian Medical Systems Inc, Palo Alto, CA). The multileaf collimator machine (MLC) log files are called Dynalog by Varian. Using an in-house developed computer program called "Dynalog QA," we automatically compare the beam delivery parameters in the log files that are generated during pretreatment point dose verification measurements, with the treatment plan to determine any discrepancies in IMRT deliveries. Fluence maps are constructed and compared between the delivered and planned beams. Since clinical introduction in June 2009, 912 machine log file analyses QA were performed by the end of 2010. Among these, 14 errors causing dosimetric deviation were detected and required further investigation and intervention. These errors were the result of human operating mistakes, flawed treatment planning, and data modification during plan file transfer. Minor errors were also reported in 174 other log file analyses, some of which stemmed from false positives and unreliable results; the origins of these are discussed herein. It has been demonstrated that the machine log file analysis is a robust, efficient, and reliable QA process capable of detecting errors originating from human mistakes, flawed planning, and data transfer problems. The possibility of detecting these errors is low using point and planar dosimetric measurements. Copyright © 2013 American Society for Radiation Oncology. Published by Elsevier Inc. All rights reserved.

  14. DIGITAL ONCOLOGY PATIENT RECORD - HETEROGENEOUS FILE BASED APPROACH

    Directory of Open Access Journals (Sweden)

    Nikolay Sapundzhiev

    2010-12-01

    Full Text Available Introduction: Oncology patients need extensive follow-up and meticulous documentation. The aim of this study was to introduce a simple, platform independent file based system for documentation of diagnostic and therapeutic procedures in oncology patients and test its function.Material and methods: A file-name based system of the type M1M2M3.F2 was introduced, where M1 is a unique identifier for the patient, M2 is the date of the clinical intervention/event, M3 is an identifier for the author of the medical record and F2 is the specific software generated file-name extension.Results: This system is in use at 5 institutions, where a total of 11 persons on 14 different workstations inputted 16591 entries (files for 2370. The merge process was tested on 2 operating systems - when copied together all files sort up as expected by patient, and for each patient in a chronological order, providing a digital cumulative patient record, which contains heterogeneous file formats.Conclusion: The file based approach for storing heterogeneous digital patient related information is an reliable system, which can handle open-source, proprietary, general and custom file formats and seems to be easily scalable. Further development of software for automatic checks of the integrity and searching and indexing of the files is expected to produce a more user-friendly environment

  15. A new LP formulation of the admission control problem modelled as an MDP under average reward criterion

    Science.gov (United States)

    Pietrabissa, Antonio

    2011-12-01

    The admission control problem can be modelled as a Markov decision process (MDP) under the average cost criterion and formulated as a linear programming (LP) problem. The LP formulation is attractive in the present and future communication networks, which support an increasing number of classes of service, since it can be used to explicitly control class-level requirements, such as class blocking probabilities. On the other hand, the LP formulation suffers from scalability problems as the number C of classes increases. This article proposes a new LP formulation, which, even if it does not introduce any approximation, is much more scalable: the problem size reduction with respect to the standard LP formulation is O((C + 1)2/2 C ). Theoretical and numerical simulation results prove the effectiveness of the proposed approach.

  16. Implementing eco friendly highly reliable upload feature using multi 3G service

    Science.gov (United States)

    Tanutama, Lukas; Wijaya, Rico

    2017-12-01

    The current trend of eco friendly Internet access is preferred. In this research the understanding of eco friendly is minimum power consumption. The devices that are selected have operationally low power consumption and normally have no power consumption as they are hibernating during idle state. To have the reliability a router of a router that has internal load balancing feature will provide the improvement of previous research on multi 3G services for broadband lines. Previous studies emphasized on accessing and downloading information files from Public Cloud residing Web Servers. The demand is not only for speed but high reliability of access as well. High reliability will mean mitigating both direct and indirect high cost due to repeated attempts of uploading and downloading the large files. Nomadic and mobile computer users need viable solution. Following solution for downloading information has been proposed and tested. The solution is promising. The result is now extended to providing reliable access line by means of redundancy and automatic reconfiguration for uploading and downloading large information files to a Web Server in the Cloud. The technique is taking advantage of internal load balancing feature to provision a redundant line acting as a backup line. A router that has the ability to provide load balancing to several WAN lines is chosen. The WAN lines are constructed using multiple 3G lines. The router supports the accessing Internet with more than one 3G access line which increases the reliability and availability of the Internet access as the second line immediately takes over if the first line is disturbed.

  17. Fast probabilistic file fingerprinting for big data.

    Science.gov (United States)

    Tretyakov, Konstantin; Laur, Sven; Smant, Geert; Vilo, Jaak; Prins, Pjotr

    2013-01-01

    Biological data acquisition is raising new challenges, both in data analysis and handling. Not only is it proving hard to analyze the data at the rate it is generated today, but simply reading and transferring data files can be prohibitively slow due to their size. This primarily concerns logistics within and between data centers, but is also important for workstation users in the analysis phase. Common usage patterns, such as comparing and transferring files, are proving computationally expensive and are tying down shared resources. We present an efficient method for calculating file uniqueness for large scientific data files, that takes less computational effort than existing techniques. This method, called Probabilistic Fast File Fingerprinting (PFFF), exploits the variation present in biological data and computes file fingerprints by sampling randomly from the file instead of reading it in full. Consequently, it has a flat performance characteristic, correlated with data variation rather than file size. We demonstrate that probabilistic fingerprinting can be as reliable as existing hashing techniques, with provably negligible risk of collisions. We measure the performance of the algorithm on a number of data storage and access technologies, identifying its strengths as well as limitations. Probabilistic fingerprinting may significantly reduce the use of computational resources when comparing very large files. Utilisation of probabilistic fingerprinting techniques can increase the speed of common file-related workflows, both in the data center and for workbench analysis. The implementation of the algorithm is available as an open-source tool named pfff, as a command-line tool as well as a C library. The tool can be downloaded from http://biit.cs.ut.ee/pfff.

  18. A Reliable File Group Sending Method Based on Low-bandwidth VHF Radio%一种超短波电台低带宽下文件可靠群发方法

    Institute of Scientific and Technical Information of China (English)

    杨紫薇; 丁敬海; 张士军

    2016-01-01

    在现代连队指挥系统内,普遍采用无线超短波电台传输文件作为通信方式。传统的发送方式是发送方不断检测接收节点的应答帧来判断是否需要续传文件,但在文件群发过程中,发送方频繁查询接收方是否成功接收会严重占用带宽,造成网络瘫痪,从而导致文件传输成功率低下。然而作为连队指挥系统的可靠性要求之一,在超短波电台传输带宽较低(4800 KBps)的情况下,指挥车对作战单元群发文件的成功率决不能低于90%。为了解决这一难题,提出了一种新的文件可靠群发方法,该方法对发送方设计通信首帧,将文件分割编序封装并按周期顺序发送,同时各个接收节点对文件进行CRC校验,索引漏帧并主动发起补传要求。通过这种通信方法,连队通信网络内,指挥车可以一次将10 KB的文件发送至10个作战单元,经过测试,数据通信成功率保持在90%以上。%In company’ s modern command system,files transmission by wireless FM radio is a universal communication method. The traditional sending method is that the sender determines whether to resume files or not by detecting response frame continuously from the receiver. But during the file group sending process,if the sender checks the file transfer result from the receiver frequently,then bandwidth may be consumed seriously and network paralysis even arises,thus the low success rate of file transfer will be caused. As one of the reliability requirements of company command system,the success rate of file group transfer must reach more than 90% by low bandwidth VHF radio (4 800 Kbps). In order to solve this problem,a reliable file group sending method is proposed in this paper,in which a kind of head frame is designed for the sender. The files are divided into several frames,a sequence number is assigned to each frame,and then each file frame is sent in order. Meanwhile, the receivers

  19. 99mTc-MDP scintigraphy of femoral head necrosis following femoral neck fracture

    International Nuclear Information System (INIS)

    Lee, Soon Jin; Lee, Jun Hyung; Kim, Eun Kyung; Lee, Sun Wha; Kim, Soon Yong

    1985-01-01

    Secondary ischemic necrosis of femoral head due to loss of blood supply following to femoral neck fracture is well known. The regional distribution of bone-seeking radiopharmaceuricals in the skeleton can depend on a number of factors, but bone blood flow is a major physiological determinant of regional skeletal uptake of Tc-99m polyphosphate and bone imaging may thus be used for the evaluation of vascularity of the femoral head. The authors made a comparative study of scintigraphic findings and operative findings of 28 cases of femoral neck fracture treated at Kyung Hee University Hospital from April 1980 to May 1984. The results were as follows: 1. In 16 cases of proven avascular necorsis of femoral head, scintigraphy showed absent or decreased activity in 14 cases (87.5%), while radiography showed increased density in 10 cases (62.5%). 2. In 12 cases of proven vital femoral head, scintigraphy showed increased activity in 9 cases (75%) and radiography showed decreased density in 9 cases (75%). 3. 99mTc-MDP scintigraphy was an excellent and useful method for assessing bone vitality of femoral head

  20. Reliable Download Delivery in a Terrestrial DAB Network

    NARCIS (Netherlands)

    Schiphorst, Roelof; Shao, X.; Slump, Cornelis H.

    2008-01-01

    Reliable file transfer is important in broadcast networks. In this paper, we have investigated if it is useful to extend the DAB standard with Fountain codes. To evaluate this, results from measurements in a live Single Frequency Network (SFN) were used. Our results show that the existing error

  1. Extending DIRAC File Management with Erasure-Coding for efficient storage

    CERN Document Server

    Skipsey, Samuel Cadellin; Britton, David; Crooks, David; Roy, Gareth

    2015-01-01

    The state of the art in Grid style data management is to achieve increased resilience of data via multiple complete replicas of data files across multiple storage endpoints. While this is effective, it is not the most space-efficient approach to resilience, especially when the reliability of individual storage endpoints is sufficiently high that only a few will be inactive at any point in time. We report on work performed as part of GridPP\\cite{GridPP}, extending the Dirac File Catalogue and file management interface to allow the placement of erasure-coded files: each file distributed as N identically-sized chunks of data striped across a vector of storage endpoints, encoded such that any M chunks can be lost and the original file can be reconstructed. The tools developed are transparent to the user, and, as well as allowing up and downloading of data to Grid storage, also provide the possibility of parallelising access across all of the distributed chunks at once, improving data transfer and IO performance. ...

  2. 75 FR 6077 - Self-Regulatory Organizations; The NASDAQ Stock Market LLC; Notice of Filing and Immediate...

    Science.gov (United States)

    2010-02-05

    ...-Regulatory Organizations; The NASDAQ Stock Market LLC; Notice of Filing and Immediate Effectiveness of... given that on January 29, 2010, The NASDAQ Stock Market LLC (``Nasdaq'' or the ``Exchange'') filed with... markets. Such assessments consider factors such as a destination's latency, fill rates, reliability, and...

  3. Evaluation of 99mTc-MDP bone imaging in monitoring the muscle-pedicle bone graft osteogenic activation

    International Nuclear Information System (INIS)

    Sang Shibiao; Wu Yiwei; Zhang Wei; Jiang Yimin; Chen Guangxiang; Dong Tianhua

    2002-01-01

    Nine mature and healthy dogs were divided into 4 groups randomly. The first group consists of 3 dogs, and the rest groups, 2 dogs. Self-control way was used. The left ilium was the experimental site, where the bone piece with sartorial muscle attached was cut from ilium. The right side served as control, where the graft bone from ilium was wrapped up with silica gel, then fixed subcutaneously. The pedicled bone pieces were retrieved in 2, 4, 6, 8 weeks after surgery, the size of graft bones from two sides were the same. Survival range, osteogenic formation of muscle-pedicle bone were examined by 99m Tc-MDP bone imaging and histological method to evaluate the clinical value of treatment of ischemic osteonecrosis of the femoral head with muscle-pedicle bone grafting. The results were as follows: 1. The part of bone attached by the sartorial survived, but osteonecrosis was observed at the location of 1.2-1.7 cm from attached point of muscle. 2. There were two forms observed in the course of osteogenic activation of muscle-pedicle bone. Under the reduction of mechanical stimulation and blood supply, bone marrow tissue was replaced by fibro-granulation tissue and new capillary in the survival part, while the survival bone of proximal part grew distally and gradually replace the dead bone of distal part. 3. Histological examination revealed that small amounts of fibro-granulation tissue and new capillary appeared in 2nd week, primary trabeculae appeared in 6th week, and in 8th week, some trabeculae recovered their normal appearance and osteogenic cell reduced remarkably. 4. Survival range of muscle-pedicle graft bone was directly proportional to the width of muscle pedicle. Therefore, radionuclide bone imaging and histological examination demonstrated that muscle-pedicle graft bone was a piece of bone with relatively poor blood supply, its effect is repairing necrosis and collapse of the femoral head is limited. 99m Tc-MDP bone imaging may be an effective and first

  4. Screening Criteria for a Room Cooling Failure of the AFW MDP Room

    International Nuclear Information System (INIS)

    Hwang, Mee Jeong; Yoon, Churl; Yang, Joon Eon; Park, Joo Hwan

    2006-01-01

    In this paper, we performed a heat up calculation for the Auxiliary Feedwater Motor Operated Pump (AFW MDP) room, PAB-077-11A with CFX-10 and RATT when the HVAC (Heating, Ventilation, and Air Condition) system is failed. We also reviewed the operability of the components under a loss of the HVAC. Room cooling failure does not need to be modeled if the components maintain their operability after a loss of a room cooling function during the mission time. ASME Standard describes that a recovery action can be credited if the related recovery action is included in the procedure or there are similar recovery experiences in the plant. However, there is no description about the recovery action of the HVAC in the EOP (Emergency Operation Procedure) of the UCN3, 4 under the situation of a loss of the HVAC. However, if we consider the HVAC failure in the PSA FT model, the problem is that the unavailability induced from a loss of the HVAC is unrealistically high. From a viewpoint of the PSA, it is not true that the related system always fails even if the HVAC system fails. Therefore, we reviewed the necessity of the HVAC model through two cases of a room heat up calculation under the situation of a loss of the HVAC system with conservative and realistic input data respectively

  5. Reliability Testing Using the Vehicle Durability Simulator

    Science.gov (United States)

    2017-11-20

    techniques are employed to reduce test and simulation time. Through application of these processes and techniques the reliability characteristics...remote parameter control (RPC) software. The software is specifically designed for the data collection, analysis, and simulation processes outlined in...the selection process for determining the desired runs for simulation . 4.3 Drive File Development. After the data have been reviewed and

  6. Diagnostic criterial to differentiate medial meniscal injury from degenerative changes on 99mTc-MDP knee SPECT in patients with chronic knee pain

    International Nuclear Information System (INIS)

    Paeng, Jin Chul; Chung, June Key; Kang, Won Jun; So, Young; Lee, Dong Soo; Lee, Myung Chul; Yoo, Jae Ho; Lee, Myung Chul; Jeong, Hwan Jeong

    2003-01-01

    In patients with chronic knee pain, the diagnostic performance of 99m Tc-MDP knee SPECT for internal derangement of knee is deteriorated due to degenerative changes. In this study, we tried to establish diagnostic criteria to differentiate medial meniscal injury (MMI) from degenerative change (DC) when the uptake in increased in medial compartment. A total of 49 knee SPECT of the patients with chronic(more than 3 months) knee pain, which showed increased 99m Tc-MDP uptake in the medial compartment, were included in this study. The diagnosis was confirmed by arthroscopy. On knee SPECT, 3 diagnosic criteria for MMI were investigated. In Criterion, I, MMI was diagnosed when crescentic uptake was observed in the medial tibial plateau. In Criterion II, crescentic uptake was further classified into anterior, mid, posterior, and diffuse patterns, according to the location of maximal uptake; and only crescentic mid, posterior, and diffuse patterns were diagnosed as MMI. In Criterion III, MMI was diagnosed when medial tibial plateau showed higher activity then medial femoral condyle. The diagnostic performance of the 3 criteria was compared. The sensitivity and specificity were 93% and 14% in Criterion I, 89% and 38% in Criterion II, and 75% and 67% in Criterion III, respectively. Criterion III had significantly improve diagnostic performance, especially, specificity. In this study, we established a practical diagnostic criterion to differentiate MMI from DC on knee SPECT. The result is helpful to improve the diagnostic value of knee SPECT as a screening test for chronic knee pain

  7. Case file coding of child maltreatment: Methods, challenges, and innovations in a longitudinal project of youth in foster care☆

    Science.gov (United States)

    Huffhines, Lindsay; Tunno, Angela M.; Cho, Bridget; Hambrick, Erin P.; Campos, Ilse; Lichty, Brittany; Jackson, Yo

    2016-01-01

    State social service agency case files are a common mechanism for obtaining information about a child’s maltreatment history, yet these documents are often challenging for researchers to access, and then to process in a manner consistent with the requirements of social science research designs. Specifically, accessing and navigating case files is an extensive undertaking, and a task that many researchers have had to maneuver with little guidance. Even after the files are in hand and the research questions and relevant variables have been clarified, case file information about a child’s maltreatment exposure can be idiosyncratic, vague, inconsistent, and incomplete, making coding such information into useful variables for statistical analyses difficult. The Modified Maltreatment Classification System (MMCS) is a popular tool used to guide the process, and though comprehensive, this coding system cannot cover all idiosyncrasies found in case files. It is not clear from the literature how researchers implement this system while accounting for issues outside of the purview of the MMCS or that arise during MMCS use. Finally, a large yet reliable file coding team is essential to the process, however, the literature lacks training guidelines and methods for establishing reliability between coders. In an effort to move the field toward a common approach, the purpose of the present discussion is to detail the process used by one large-scale study of child maltreatment, the Studying Pathways to Adjustment and Resilience in Kids (SPARK) project, a longitudinal study of resilience in youth in foster care. The article addresses each phase of case file coding, from accessing case files, to identifying how to measure constructs of interest, to dealing with exceptions to the coding system, to coding variables reliably, to training large teams of coders and monitoring for fidelity. Implications for a comprehensive and efficient approach to case file coding are discussed. PMID

  8. Utility of MDP bone SPECT in the detection of osseous invasion in craniofacial malignancies

    International Nuclear Information System (INIS)

    Saeed, S.; Haq, S.; Sohaib, M.; Khan, A.N.

    2002-01-01

    Aim: The study was designed to observe the role of SPECT imaging for the detection of osseous invasion in craniofacial malignancies. Material and Methods: Radionuclide bone imaging with Tc-99m MDP was done on 20 patients with different craniofacial malignancies. The planar imaging comprised of anterior, lateral and oblique lateral views of the skull. SPECT imaging was done taking 64 views of the skull in a 360 deg. circular path, each of 40 seconds with 128x128 matrix. Visual interpretation of the scans was done and a score of 0, 1, or 2 allocated, representing a lesion as definitely absent, doubtful or definitely present, respectively. SPECT images were compared with planar scans. Results: SPECT was proven superior to planar imaging and radiographs in detection as well as efficient demonstration of the extent of osseous invasion of a craniofacial cancer. The sensitivity was 100% for SPECT, 83.3% for planar and 33.3% for radiographs. Conclusion: SPECT imaging of the skull can serve as an extremely useful complementary investigation in the patients with craniofacial malignancies to assess them for osseous invasion, particularly in tumors likely to invade the skull base

  9. {sup 99m}Tc-MDP scintigraphy of femoral head necrosis following femoral neck fracture

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Soon Jin; Lee, Jun Hyung; Kim, Eun Kyung; Lee, Sun Wha; Kim, Soon Yong [Kyung Hee University School of Medicine, Seoul (Korea, Republic of)

    1985-02-15

    Secondary ischemic necrosis of femoral head due to loss of blood supply following to femoral neck fracture is well known. The regional distribution of bone-seeking radiopharmaceuricals in the skeleton can depend on a number of factors, but bone blood flow is a major physiological determinant of regional skeletal uptake of Tc-99m polyphosphate and bone imaging may thus be used for the evaluation of vascularity of the femoral head. The authors made a comparative study of scintigraphic findings and operative findings of 28 cases of femoral neck fracture treated at Kyung Hee University Hospital from April 1980 to May 1984. The results were as follows: 1. In 16 cases of proven avascular necorsis of femoral head, scintigraphy showed absent or decreased activity in 14 cases (87.5%), while radiography showed increased density in 10 cases (62.5%). 2. In 12 cases of proven vital femoral head, scintigraphy showed increased activity in 9 cases (75%) and radiography showed decreased density in 9 cases (75%). 3. 99mTc-MDP scintigraphy was an excellent and useful method for assessing bone vitality of femoral head.

  10. In-vivo behavior of tin-117m(2+ and 4+)-labeled DTPA and MDP. Preparation, tissue distribution in mice, and imaging in dogs

    International Nuclear Information System (INIS)

    Srivastava, S.C.; Richards, P.; Meinken, G.E.; Som, P.; Knapp, F.F. Jr.; Butler, T.A.

    1982-01-01

    Tissue distribution in mice of stannous chloride (pH 2), and of stannous as well as stannic chelates of MDP and DTPA is described. The bone-to-tissue ratios of these compounds are evaluated. High bone uptake of all these compounds point out the high affinity of tin for bone despite the chemically diverse ligands. Whole body autoradiographs of mice injected with tin-117m(IV)-DTPA demonstrate the almost exclusive localization of tin-117m activity in bone. Clarity of bone images in a dog, obtained up to 15 days following the injection of tin-117m(IV)-DTPA is demonstrated

  11. 99mTc MDP SPECT-CT-Based Modified Mirels Classification for Evaluation of Risk of Fracture in Skeletal Metastasis: A Pilot Study.

    Science.gov (United States)

    Riaz, Saima; Bashir, Humayun; Niazi, Imran Khalid; Butt, Sumera; Qamar, Faisal

    2018-06-01

    Mirels' scoring system quantifies the risk of sustaining a pathologic fracture in osseous metastases of weight bearing long bones. Conventional Mirels' scoring is based on radiographs. Our pilot study proposes Tc MDP bone SPECT-CT based modified Mirels' scoring system and its comparison with conventional Mirels' scoring. Cortical lysis was noted in 8(24%) by SPECT-CT versus 2 (6.3%) on X-rays. Additional SPECT-CT parameters were; circumferential involvement [1/4 (31%), 1/2 (3%), 3/4 (37.5%), 4/4 (28%)] and extra-osseous soft tissue [3%]. Our pilot study suggests the potential role of SPECT-CT in predicting risk of fracture in osseous metastases.

  12. Reactor fuel performance data file, 1985 edition

    International Nuclear Information System (INIS)

    Harayama, Yasuo; Fujita, Misao; Watanabe, Kohji.

    1986-07-01

    In safety evaluation and integrity studies of reactor fuel, data on fuel performance are the most basic materials. The Fuel Reliability Laboratory No.1 has obtained the fuel performance data by joining in some international programs to study the safety and integrity of fuel. Those data have only used for the studies in the above two fields. However, if the data are rearranged and compiled in a easily usable form, they can be utilized in other field of studies. Then, a 'data file' on fuel performance is beeing compiled by adding data from open literatures to those obtained in international programs. The present report is prepared on the basis of the data file compiled by March in 1986. (author)

  13. Next generation WLCG File Transfer Service (FTS)

    CERN Multimedia

    CERN. Geneva

    2012-01-01

    LHC experiments at CERN and worldwide utilize WLCG resources and middleware components to perform distributed computing tasks. One of the most important tasks is reliable file replication. It is a complex problem, suffering from transfer failures, disconnections, transfer duplication, server and network overload, differences in storage systems, etc. To address these problems, EMI and gLite have provided the independent File Transfer Service (FTS) and Grid File Access Library (GFAL) tools. Their development started almost a decade ago, in the meantime, requirements in data management have changed - the old architecture of FTS and GFAL cannot keep support easily these changes. Technology has also been progressing: FTS and GFAL do not fit into the new paradigms (cloud, messaging, for example). To be able to serve the next stage of LHC data collecting (from 2013), we need a new generation of  these tools: FTS 3 and GFAL 2. We envision a service requiring minimal configuration, which can dynamically adapt to the...

  14. Image Steganography of Multiple File Types with Encryption and Compression Algorithms

    Directory of Open Access Journals (Sweden)

    Ernest Andreigh C. Centina

    2017-05-01

    Full Text Available The goals of this study were to develop a system intended for securing files through the technique of image steganography integrated with cryptography by utilizing ZLIB Algorithm for compressing and decompressing secret files, DES Algorithm for encryption and decryption, and Least Significant Bit Algorithm for file embedding and extraction to avoid compromise on highly confidential files from exploits of unauthorized persons. Ensuing to this, the system is in acc ordance with ISO 9126 international quality standards. Every quality criteria of the system was evaluated by 10 Information Technology professionals, and the arithmetic Mean and Standard Deviation of the survey were computed. The result exhibits that m ost of them strongly agreed that the system is excellently effective based on Functionality, Reliability, Usability, Efficiency, Maintainability and Portability conformance to ISO 9126 standards. The system was found to be a useful tool for both governmen t agencies and private institutions for it could keep not only the message secret but also the existence of that particular message or file et maintaining the privacy of highly confidential and sensitive files from unauthorized access.

  15. A design for a new catalog manager and associated file management for the Land Analysis System (LAS)

    Science.gov (United States)

    Greenhagen, Cheryl

    1986-01-01

    Due to the larger number of different types of files used in an image processing system, a mechanism for file management beyond the bounds of typical operating systems is necessary. The Transportable Applications Executive (TAE) Catalog Manager was written to meet this need. Land Analysis System (LAS) users at the EROS Data Center (EDC) encountered some problems in using the TAE catalog manager, including catalog corruption, networking difficulties, and lack of a reliable tape storage and retrieval capability. These problems, coupled with the complexity of the TAE catalog manager, led to the decision to design a new file management system for LAS, tailored to the needs of the EDC user community. This design effort, which addressed catalog management, label services, associated data management, and enhancements to LAS applications, is described. The new file management design will provide many benefits including improved system integration, increased flexibility, enhanced reliability, enhanced portability, improved performance, and improved maintainability.

  16. Development of reliability databases and the particular requirements of probabilistic risk analyses

    International Nuclear Information System (INIS)

    Meslin, T.

    1989-01-01

    Nuclear utilities have an increasing need to develop reliability databases for their operating experience. The purposes of these databases are often multiple, including both equipment maintenance aspects and probabilistic risk analyses. EDF has therefore been developing experience feedback databases, including the Reliability Data Recording System (SRDF) and the Event File, as well as the history of numerous operating documents. Furthermore, since the end of 1985, EDF has been preparing a probabilistic safety analysis applied to one 1,300 MWe unit, for which a large amount of data of French origin is necessary. This data concerns both component reliability parameters and initiating event frequencies. The study has thus been an opportunity for trying out the performance databases for a specific application, as well as in-depth audits of a number of nuclear sites to make it possible to validate numerous results. Computer aided data collection is also on trial in a number of plants. After describing the EDF operating experience feedback files, we discuss the particular requirements of probabilistic risk analyses, and the resources implemented by EDF to satisfy them. (author). 5 refs

  17. In vitro effect of cyclophosphamide on the binding of radiopharmaceuticals (99m Tc O4- and 99m Tc-MDP) to blood elements

    International Nuclear Information System (INIS)

    Ripoll-Hamer, E.; Paula, E.F. de; Bernardo Filho, M.; Freitas, L.C.; Fonseca, L.M.; Gutfilen, B.

    1995-01-01

    Using an in vitro model, it was evaluated the effect of cyclophosphamide on percent radioactivity of 99m Tc O - 4 and methylene diphosphonic acid ( 99m Tc-MDP) bound to isolated blood elements. Blood samples were incubated with the two radiopharmaceuticals, plasma and blood cells were separated and precipitated, and soluble and insoluble fractions were separated. To evaluate the effect of cyclophosphamide, blood was incubated with this drug 1 h prior to the addition of the radiopharmaceuticals. The fraction of 99m Tc O - 4 radioactivity was slightly higher in plasma (61.2 to 53.8%) than in blood cells (38.8 to 46.2%) up to 6 h. The amount of 99m Tc - MDP radioactivity was higher in plasma (91.1 to 87.2%) than in blood cells (8.9 to 12.8%) up to 24 h. The binding of 99m Tc O - 4 to the insoluble fraction of plasma (4.9 to 6.1%) was low. But a small blockade (9.8 to 4.8%) was observed at 24 h. From 3 h on, cyclophosphamide slightly inhibited 99m Tc O - 4 binding to blood cells (23.1 to 16.6%) and increased it at 24 h (31.2 to 14.3%). The effect of cyclophosphamide was strongest at 24 h, with decreased radioactivity binding to the insoluble fraction of plasma (47.6 to 27.0%) and blood cells (51.2 to 23.2%). The fact that cyclophosphamide can bind to plasma proteins and/or cross the cell membrane explains in part the results obtained. (author). 20 refs., 2 tabs

  18. Evaluation of the utility of 99m Tc-MDP bone scintigraphy versus MIBG scintigraphy and cross-sectional imaging for staging patients with neuroblastoma.

    Science.gov (United States)

    Gauguet, Jean-Marc; Pace-Emerson, Tamara; Grant, Frederick D; Shusterman, Suzanne; DuBois, Steven G; Frazier, A Lindsay; Voss, Stephan D

    2017-11-01

    Accurate staging of neuroblastoma requires multiple imaging examinations. The purpose of this study was to determine the relative contribution of 99m Tc-methylene diphosphonate (MDP) bone scintigraphy (bone scan) versus metaiodobenzylguanidine scintigraphy (MIBG scan) for accurate staging of neuroblastoma. A medical record search by the identified patients with neuroblastoma from 1993 to 2012 who underwent both MIBG and bone scan for disease staging. Cross-sectional imaging was used to corroborate the scintigraphy results. Clinical records were used to correlate imaging findings with clinical staging and patient management. One hundred thirty-two patients underwent both MIBG and bone scan for diagnosis. All stage 1 (n = 12), 2 (n = 8), and 4S (n = 4) patients had a normal bone scan with no skeletal MIBG uptake. Six of 30 stage 3 patients had false (+) bone scans. In the 78 stage 4 patients, 58/78 (74%) were both skeletal MIBG(+)/bone scan (+). In 56 of the 58 cases, skeletal involvement detected with MIBG was equal to or greater than that detected by bone scan. Only 3/78 had (-) skeletal MIBG uptake and (+) bone scans; all 3 had other sites of metastatic disease. Five of 78 had (+) skeletal MIBG with a (-) bone scan, while 12/78 had no skeletal involvement by either MIBG or bone scan. In no case did a positive bone scan alone determine a stage 4 designation. In the staging of neuroblastoma, 99m Tc-MDP bone scintigraphy does not identify unique sites of disease that affect disease stage or clinical management, and in the majority of cases bone scans can be omitted from the routine neuroblastoma staging algorithm. © 2017 Wiley Periodicals, Inc.

  19. Labelled Preformed liposomes with 99MTC-DTPA, 99 MTC-ECD, 99MTC-MDP and 99MTC-MIBI : Labelling procedures and stability studies

    International Nuclear Information System (INIS)

    Savio, E.O.; Teran, M.A.; Vales, M.E.; Frier, M.

    2004-01-01

    Liposomes labelled with gamma e miters like 99mTc, can be used for scintigraphic imaging to non-invasively track and quantify the distribution of liposomes in the body. In vitro studies were done to choose a suitable radiopharmaceutical (RF) to be attached to performed liposomes. 99mTc-Complexes (DTPA, ECD, MDP, MIBI) were used to label collagen liposomes. Commercial kits were labelled with 99mTc04-(TechnoNuclear). Quality controls of the RF were performed. Collagen liposomes suspended in saline 0.9% were incubated at 4.25.37 and 60 for 30 min. Efficiency of the labelling procedure was determined by gel filtration using Sephadex G25 (Pharmacia) and NaC10.9%. Samples of 100mL (74MBq), were seeded and fractions of 0.5mL were colleted and measured in an ionisation chamber (Capintec CRC). Stability of the labelled liposomes was assessed incubating 0.5mL, of the suspension with 1mL of human serum during 30 min at 37 . Dialysis was performed using dialysis bags of 64 K pore size and NaCI 0.9% at room temperature. Samples of the saline bath were collected at 30.60 and 90 min. and measured in a solid scintillation counter Ortec.Liposomes labelled with 99mTc-DTPA and 99mTcMIBI showed a labelling efficiency of 80%; liposomes incubated with 99mTc-MDP were labelled in a 50% and 99mTc-ECD did not bind to liposomes in the conditions of study. Incubation of labelled liposomes with human serum showed 50% of strong binding to the plasmatic proteins for 99mTc-DTPA but low values (5%) for the other specimens. Labelled liposomes were achieved, with different RF, showing a suitable in vitro stability to perform in vivo studies

  20. Storage Manager and File Transfer Web Services

    International Nuclear Information System (INIS)

    William A Watson III; Ying Chen; Jie Chen; Walt Akers

    2002-01-01

    Web services are emerging as an interesting mechanism for a wide range of grid services, particularly those focused upon information services and control. When coupled with efficient data transfer services, they provide a powerful mechanism for building a flexible, open, extensible data grid for science applications. In this paper we present our prototype work on a Java Storage Resource Manager (JSRM) web service and a Java Reliable File Transfer (JRFT) web service. A java client (Grid File Manager) on top of JSRM and is developed to demonstrate the capabilities of these web services. The purpose of this work is to show the extent to which SOAP based web services are an appropriate direction for building a grid-wide data management system, and eventually grid-based portals

  1. A Case of with Transient splenic Hot Uptake on 99mTc-Methylene Diphosphonate (MDP) Bone Scan Following Blunt Abodominal Trauma with Underlying Liver Cirrhosis

    International Nuclear Information System (INIS)

    Won, Jong Hyeon; Kim, Jae Myung; Kim, Jung Han; Choo, Gil Yeon; Park, Seok Oh; Sung, Sang Kyu; Choi, Dae Seob; Kim, Chin Seung

    1993-01-01

    We report a case of 33-year-old man with a transient splenic uptake who had traumatic multiple rib fractures and hemoperitoneum combined with underlying liver cirrhosis, liver cirrhosis with liver bed laceration and splenomegaly without any other demonstrable splenic lesion due to traffic accident was found by abdominal ultrasound and surgery. Incidentally, 99m Tc-MDP Bone scan showed whole prominent splenic uptake, spleen was also visible on 99m Tc Tin colloid liver scan. We suggest the splenic uptake of the radionuclide temporary splenic infarct to the transient total splenic infarction or unknown traumatic effect.

  2. Decay data file based on the ENSDF file

    Energy Technology Data Exchange (ETDEWEB)

    Katakura, J. [Japan Atomic Energy Research Inst., Tokai, Ibaraki (Japan). Tokai Research Establishment

    1997-03-01

    A decay data file with the JENDL (Japanese Evaluated Nuclear Data Library) format based on the ENSDF (Evaluated Nuclear Structure Data File) file was produced as a tentative one of special purpose files of JENDL. The problem using the ENSDF file as primary source data of the JENDL decay data file is presented. (author)

  3. Reliability data banks at Electricite de France (EDF)

    International Nuclear Information System (INIS)

    Procaccia, H.

    1991-01-01

    When Electricite de France opted for a policy of rapid development of PWR nuclear power plants only foreign data was available on plant operation to start a computerized data bank. Since 1978 however, a specific French data bank has been built up. The collected data are recorded on a central computer near Paris. This article describes the component reliability bank. First a history of the banks' development, which has taken place in four steps, is described. Then the data bank itself, known as SRDF, is explained. It allows computation of the component failure rates in operation, on standby or on demand, their development with time, the corresponding unavailability and repair time, the modes and causes of failure, the affected subcomponents and the consequences of the failure on the plant. To achieve this SRDF has three subfiles, the identification file, the operating file and the failure file. The components monitored are listed. Data processing, and data retrieval are explained and some examples given of studies performed using SRDF. (UK)

  4. Enhancement of immune response towards non-lipidized Borrelia burgdorferi recombinant OspC antigen by binding onto the surface of metallochelating nanoliposomes with entrapped lipophilic derivatives of norAbuMDP

    Czech Academy of Sciences Publication Activity Database

    Křupka, M.; Mašek, J.; Bartheldyová, E.; Turánek Knotigová, P.; Plocková, J.; Korvasová, Z.; Škrabalová, M.; Koudelka, Š.; Kulich, P.; Zachová, K.; Czerneková, L.; Strouhal, O.; Horynová, M.; Šebela, M.; Miller, A. D.; Ledvina, Miroslav; Raška, M.; Turánek, J.

    2012-01-01

    Roč. 160, č. 2 (2012), s. 374-381 ISSN 0168-3659 R&D Projects: GA ČR(CZ) GAP304/10/1951; GA TA ČR TA01011165; GA AV ČR(CZ) KAN200520703; GA AV ČR KAN200100801 Grant - others:GA UP(CZ) LF-2010-014; GA UP(CZ) LF-2011-002 Institutional research plan: CEZ:AV0Z40550506 Keywords : Borrelia burgdorferi * OspC * metallochelating liposomes * MDP Subject RIV: CC - Organic Chemistry Impact factor: 7.633, year: 2012

  5. 99mTc bone scanning agents preparation and chemical analysis of Tc(Sn)pyrophosphate, Tc(Sn)MDP and Tc(Sn)HMDP

    International Nuclear Information System (INIS)

    Kroesbergen, J.

    1986-01-01

    This thesis describes a comparison of the preparation, composition and properties of three bone scanning agents: 99m Tc(Sn)pyrophosphate, 99m Tc(Sn)MDP and 99m Tc(Sn)HMDP. This study has been performed for two reasons: First to investigate the preparation and composition of the radiopharmaceuticals as a function of experimental conditions. Together with previously reported results for 99m Tc(Sn)EHDP, obtained in a similar way, this enables to use well-defined preparations of the bone scanning agents. Secondly to gain an insight in the mechanism in which the agents behave 'in vivo'. Because the 'in vivo' process is too complicated to study directly, it seemed more appropriate to perform 'in vitro' investigations as simplifications of the 'in vivo' situation. 304 refs.; 26 figs.; 31 tabs

  6. Extending DIRAC File Management with Erasure-Coding for efficient storage.

    Science.gov (United States)

    Cadellin Skipsey, Samuel; Todev, Paulin; Britton, David; Crooks, David; Roy, Gareth

    2015-12-01

    The state of the art in Grid style data management is to achieve increased resilience of data via multiple complete replicas of data files across multiple storage endpoints. While this is effective, it is not the most space-efficient approach to resilience, especially when the reliability of individual storage endpoints is sufficiently high that only a few will be inactive at any point in time. We report on work performed as part of GridPP[1], extending the Dirac File Catalogue and file management interface to allow the placement of erasure-coded files: each file distributed as N identically-sized chunks of data striped across a vector of storage endpoints, encoded such that any M chunks can be lost and the original file can be reconstructed. The tools developed are transparent to the user, and, as well as allowing up and downloading of data to Grid storage, also provide the possibility of parallelising access across all of the distributed chunks at once, improving data transfer and IO performance. We expect this approach to be of most interest to smaller VOs, who have tighter bounds on the storage available to them, but larger (WLCG) VOs may be interested as their total data increases during Run 2. We provide an analysis of the costs and benefits of the approach, along with future development and implementation plans in this area. In general, overheads for multiple file transfers provide the largest issue for competitiveness of this approach at present.

  7. 75 FR 57761 - North American Electric Reliability Corporation; Notice of Filing September 14, 2010.

    Science.gov (United States)

    2010-09-22

    ... request for approval of implementation plans for Generator Owners and Generator Operators of nuclear power..., 888 First Street, NE., Washington, DC 20426. This filing is accessible on-line at http://www.ferc.gov... Washington, DC. There is an ``eSubscription'' link on the Web site that enables subscribers to receive e-mail...

  8. An FEC Adaptive Multicast MAC Protocol for Providing Reliability in WLANs

    Science.gov (United States)

    Basalamah, Anas; Sato, Takuro

    For wireless multicast applications like multimedia conferencing, voice over IP and video/audio streaming, a reliable transmission of packets within short delivery delay is needed. Moreover, reliability is crucial to the performance of error intolerant applications like file transfer, distributed computing, chat and whiteboard sharing. Forward Error Correction (FEC) is frequently used in wireless multicast to enhance Packet Error Rate (PER) performance, but cannot assure full reliability unless coupled with Automatic Repeat Request forming what is knows as Hybrid-ARQ. While reliable FEC can be deployed at different levels of the protocol stack, it cannot be deployed on the MAC layer of the unreliable IEEE802.11 WLAN due to its inability to exchange ACKs with multiple recipients. In this paper, we propose a Multicast MAC protocol that enhances WLAN reliability by using Adaptive FEC and study it's performance through mathematical analysis and simulation. Our results show that our protocol can deliver high reliability and throughput performance.

  9. A Case of with Transient splenic Hot Uptake on {sup 99m}Tc-Methylene Diphosphonate (MDP) Bone Scan Following Blunt Abodominal Trauma with Underlying Liver Cirrhosis

    Energy Technology Data Exchange (ETDEWEB)

    Won, Jong Hyeon; Kim, Jae Myung; Kim, Jung Han; Choo, Gil Yeon; Park, Seok Oh; Sung, Sang Kyu; Choi, Dae Seob; Kim, Chin Seung [Sung Ae General Hospital, Seoul (Korea, Republic of)

    1993-07-15

    We report a case of 33-year-old man with a transient splenic uptake who had traumatic multiple rib fractures and hemoperitoneum combined with underlying liver cirrhosis, liver cirrhosis with liver bed laceration and splenomegaly without any other demonstrable splenic lesion due to traffic accident was found by abdominal ultrasound and surgery. Incidentally, {sup 99m}Tc-MDP Bone scan showed whole prominent splenic uptake, spleen was also visible on {sup 99m}Tc Tin colloid liver scan. We suggest the splenic uptake of the radionuclide temporary splenic infarct to the transient total splenic infarction or unknown traumatic effect.

  10. Indications of 99mTc-MDP scintigraphy bone scan in the evaluation of painful hip arthroplasties

    International Nuclear Information System (INIS)

    Eder, V.; Baulieu, F.; Secchi, V.; Gautier, B.; Pottier, J.M.; Rosset, P.

    2000-01-01

    The purpose of this study was to determine the indication of bone scintigraphy in hip prosthesis complications. Thirty-six patients and 38 hip prosthesis have had a 99 Tc-MDP scintigraphy in our laboratory between 1995 and 1997. It concerns 32 cemented total prosthesis, 3 intermediate prosthesis and 3 non-cemented total prosthesis. For 14 prosthesis, complication (loosening or infection) was confirmed by surgical operation in 12 cases (4 isolated acetabular complications, 2 isolated femoral loosening, 3 global loosening and 3 infections) or by concordant data from different examinations in 2 cases (global loosening) where intervention was unrealizable. About other patients, absence of complication was confirmed by a favourable evolution lasting at least 12 months. A cetabular and femoral complications were detected by scintigraphy respectively with a sensitivity of 100 % and 90 %, a specificity of 85 % and 78 %, a PPV of 75 % and 60 % and NPV of 100 % and 96 %. High negative predictive value allows to eliminate a prosthesis complication in the case of a normal scintigraphy and to override decision when the clinic and the radiography are doubtful. Scintigraphy may recognize other bone fixation abnormalities which may be responsible of clinical symptomatology. (authors)

  11. Nickel-Titanium Single-file System in Endodontics.

    Science.gov (United States)

    Dagna, Alberto

    2015-10-01

    This work describes clinical cases treated with a innovative single-use and single-file nickel-titanium (NiTi) system used in continuous rotation. Nickel-titanium files are commonly used for root canal treatment but they tend to break because of bending stresses and torsional stresses. Today new instruments used only for one treatment have been introduced. They help the clinician to make the root canal shaping easier and safer because they do not require sterilization and after use have to be discarded. A new sterile instrument is used for each treatment in order to reduce the possibility of fracture inside the canal. The new One Shape NiTi single-file instrument belongs to this group. One Shape is used for complete shaping of root canal after an adequate preflaring. Its protocol is simple and some clinical cases are presented. It is helpful for easy cases and reliable for difficult canals. After 2 years of clinical practice, One Shape seems to be helpful for the treatment of most of the root canals, with low risk of separation. After each treatment, the instrument is discarded and not sterilized in autoclave or re-used. This single-use file simplifies the endodontic therapy, because only one instrument is required for canal shaping of many cases. The respect of clinical protocol guarantees predictable good results.

  12. Contrast enhancement of bone imaging: use of a asymmetrical energy window of Tc99m MDP (133-145 keV)

    International Nuclear Information System (INIS)

    Elsaid, M.; Hommoud, S.; Shehab, F.; Elgazzar, A

    2004-01-01

    Objective: One of the major problems than can affect image quality of bone scan is poor target to non target ratio, due to scattered photons. The ideal Tc-99m energy spectrum is line shaped while the actual one is broader to include attenuated and scattered photons from the soft tissue. The air of this study is to evaluate the effect of asymmetrical 15% energy window of Tc-99m MDP setting at (133-154 keg) on the contrast of bone imaging in comparison to the commonly used 20% symmetrical energy window (126-154 keV). Methods: Sixty adult patients from those who are regularly referred to the clinic for bone scan were scanned twice, after intravenous injection of 925 Mbq (25mCi) of Tc-99m MDP, using 15% (133-154 keV) and 20% (126-154 keV) energy window respectively. Whole body scan was performed on 20 patients, 17 females and 3 males, with ages between 32-61 years. SPECT of the femurs were done on another 20 patients, 2 males and 18 females, with ages between 29-62 years. Planar images were acquired on 20 different patients 6 males and 14 females, with ages between 23-66 years. All technical parameters were kept the same for every group of patients. The acquisition time was recorded in case of the planar views and the count per projection was recorded for each SPECT study. Results: Our preliminary results shows that target to none target ratio were improved in all patients, using the 15% asymmetrical window, compared to the ratio obtained from imaging using the 200/o symmetrical window. The ratios wee increased by 12.4% in the planar images, 9.46% in SPECT images and 11.1% n the whole body images. The improvements in the planner images were on the expense of the acquisition time which increased by 31.1%. Conclusion: We conclude that the use of asymmetrical energy window of 15% (133-154 keV) will improve the image quality of bone scan by enhancing the contrast between bone and soft tissue. (authors)

  13. Accessing files in an Internet: The Jade file system

    Science.gov (United States)

    Peterson, Larry L.; Rao, Herman C.

    1991-01-01

    Jade is a new distribution file system that provides a uniform way to name and access files in an internet environment. It makes two important contributions. First, Jade is a logical system that integrates a heterogeneous collection of existing file systems, where heterogeneous means that the underlying file systems support different file access protocols. Jade is designed under the restriction that the underlying file system may not be modified. Second, rather than providing a global name space, Jade permits each user to define a private name space. These private name spaces support two novel features: they allow multiple file systems to be mounted under one directory, and they allow one logical name space to mount other logical name spaces. A prototype of the Jade File System was implemented on Sun Workstations running Unix. It consists of interfaces to the Unix file system, the Sun Network File System, the Andrew File System, and FTP. This paper motivates Jade's design, highlights several aspects of its implementation, and illustrates applications that can take advantage of its features.

  14. Accessing files in an internet - The Jade file system

    Science.gov (United States)

    Rao, Herman C.; Peterson, Larry L.

    1993-01-01

    Jade is a new distribution file system that provides a uniform way to name and access files in an internet environment. It makes two important contributions. First, Jade is a logical system that integrates a heterogeneous collection of existing file systems, where heterogeneous means that the underlying file systems support different file access protocols. Jade is designed under the restriction that the underlying file system may not be modified. Second, rather than providing a global name space, Jade permits each user to define a private name space. These private name spaces support two novel features: they allow multiple file systems to be mounted under one directory, and they allow one logical name space to mount other logical name spaces. A prototype of the Jade File System was implemented on Sun Workstations running Unix. It consists of interfaces to the Unix file system, the Sun Network File System, the Andrew File System, and FTP. This paper motivates Jade's design, highlights several aspects of its implementation, and illustrates applications that can take advantage of its features.

  15. The value of scintiscanning using 99mTc-MDP to assess disorders of the knee and ankle joints in orthopedic patients as compared to that of X-ray procedures

    International Nuclear Information System (INIS)

    Buyer, B.

    1983-01-01

    Relevant analyses were carried out on the basis of the data of 100 patients. The radiopharmaceutical examinations were performed using a scanner two hours after injection of 10 mCi 99mTc-MDP. Following interpretation of the density patterns, the concentration quotients of the scintiscans were calculated to permit a semi-quantitative assessment to be made. As far as arthropathies were concerned, the scintiscans did not contribute much useful information to diagnose patellar chondropathy at an early stage of the disease, nor were they seen to offer any decisive advantages over X-ray examinations in degenerative disorders of the joints. Scintiscanning was also found an unsuitable method to differentiate athritis from arthrosis. Under certain circumstances, joint scintiscanning may have an additional indication in the diagnosis of meniscitis. In rheumatoid arthritis and Sudeck's syndrome the scintiscans were found to be in better agreement with the clinical symptoms than the corresponding X-ray findings. In soft tissue disorders scintiscanning did not appear to be an adequate method to obtain additional diagnostic information. On the other hand, all types of osteopathy caused by inflammation, necrosis, neoplasms or cysts are clearly falling within the domaine of scintiscanning. Foot deformities were invariably seen to be associated with locallised concentration of the tracer substance. Owing to the limited specifity of radiopharmaceutical investigations using 99mTc-MDP, concentional X-ray examinations will indispensable in the vast majority of cases. (TRV) [de

  16. Odysseus/DFS: Integration of DBMS and Distributed File System for Transaction Processing of Big Data

    OpenAIRE

    Kim, Jun-Sung; Whang, Kyu-Young; Kwon, Hyuk-Yoon; Song, Il-Yeol

    2014-01-01

    The relational DBMS (RDBMS) has been widely used since it supports various high-level functionalities such as SQL, schemas, indexes, and transactions that do not exist in the O/S file system. But, a recent advent of big data technology facilitates development of new systems that sacrifice the DBMS functionality in order to efficiently manage large-scale data. Those so-called NoSQL systems use a distributed file system, which support scalability and reliability. They support scalability of the...

  17. Variance of [sup 99m]Tc-MDP bone imaging among the repairing process after experimental femoral head necrosis

    Energy Technology Data Exchange (ETDEWEB)

    Shibiao, Sang; Yimin, Jiang; Jinxi, Wang [Suzhou Medical Coll., Suzhou, JS (China). First Affiliated Hospital

    1993-05-01

    Six of 26 adult mongrel dogs were used as controls. Avascular necrosis of the left femoral head was induced by freezing method with liquid nitrogen and the right side being used as a self-control. The 20 dogs were divided into four groups, 5 dogs each which was sacrificed successively at 1/2, 2,2 and 6 months after operation. All of the femoral heads were studied by radionuclide bone imaging, radiological, histological and biochemical examinations. The results were as follows: [sup 99m]Tc-MDP bone imaging showed a decreased uptake at the early stage, and was gradually increased later, and reached its peak values at precollape stage at four months. Hypermetabolism state was still maintained at collapsed stage. Above changes was in coincidence with the bone imaging. As for the repairing process after necrosis, the hypermetabolic reaction in bone imaging of the femoral head correlates well with the proliferation of vessels and bone marrow cells and also the activity of tissue collagenase. Therefore, a poor bony reconstruction in the weight-bearing portion could be an important cause for late segmental collapse.

  18. Bond strength of primer/cement systems to zirconia subjected to artificial aging.

    Science.gov (United States)

    Zhao, Li; Jian, Yu-Tao; Wang, Xiao-Dong; Zhao, Ke

    2016-11-01

    Creating reliable and durable adhesion to the nonactive zirconia surface is difficult and has limited zirconia use. The introduction of functional monomers such as 10-methacryloyloxydecyl dihydrogen phosphate (MDP) appears to have enhanced bond strength to zirconia. The purpose of this in vitro study was to evaluate the long-term bond strength of several MDP-containing primer/cement systems to zirconia. Zirconia blocks were divided into 6 groups (n=24) according to the 3 primers/cements to be bonded, as follows: Scotchbond Universal/RelyX Ultimate (SU/RU; consisting of MDP-containing primer/MDP-free cement); Clearfil ceramic primer/Panavia F (CCP/PAN; consisting ofMDP-containing/MDP-containing); and Z-Prime Plus/Duo-Link (ZP/DUO; consisting ofMDP-containing/MDP-free), which were compared with 3 nonprimed groups, RU, PAN, and DUO. After bonding, each group was further divided into 3 subgroups (n=8) according to the level of aging: 24-hour storage in water at 37°C (24H); 30-day storage at 37°C (30D); and 30-day storage at 37°C followed by 3000 thermal cycles (30D/TC). After aging, a shear bond strength test and failure mode analysis were performed. The data were analyzed using 2-way ANOVA (α=.05). After aging, nearly all primer/cement groups presented significantly higher bond strength than the related nonprimed groups for each level of aging (P<.05), except for CCP/PAN versus PAN with 24H (P=.741). SU/RU had the highest bond strength among the groups for all treatments (P<.05), except for CCP/PAN versus SU/RU with 30D/TC (P=.171). Among the nonprimed groups, only RU went through 30D/TC without premature debonding. With 24H and 30D, the failure modes in SU/RU and CCP/PAN were purely mixed, whereas those in the other groups were mainly adhesive, except for RU. The superiority of the initial bond strength in SU/RU may result from some functional components other than MDP. The presence of MDP in the cement did not appear to have a positive effect on long-term bond

  19. The File Sync Algorithm of the ownCloud Desktop Clients

    CERN Multimedia

    CERN. Geneva

    2014-01-01

    The ownCloud desktop clients provide file syncing between desktop machines and the ownCloud server, available for the important desktop platforms. This presentation will give an overview of the sync algorithm used by the clients to provide a fast, reliable and robust syncing experience for the users. It will describe the phases a sync run will go through and how it is triggered. It also will provide an insight on the algorithms that decided if a file is uploaded, downloaded or even deleted on either on the local machine or in the cloud. Some examples of non obvious situations in file syncing will be described and discussed. As the ownCloud sync protocol is based on the open standard WebDAV the resulting challenges and the solutions will be illustrated. Finally a couple of frequently proposed enhancements will be reviewed and assed for the future development of the ownCloud server and syncing clients.

  20. Long term file migration. Part I: file reference patterns

    International Nuclear Information System (INIS)

    Smith, A.J.

    1978-08-01

    In most large computer installations, files are moved between on-line disk and mass storage (tape, integrated mass storage device) either automatically by the system or specifically at the direction of the user. This is the first of two papers which study the selection of algorithms for the automatic migration of files between mass storage and disk. The use of the text editor data sets at the Stanford Linear Accelerator Center (SLAC) computer installation is examined through the analysis of thirteen months of file reference data. Most files are used very few times. Of those that are used sufficiently frequently that their reference patterns may be examined, about a third show declining rates of reference during their lifetime; of the remainder, very few (about 5%) show correlated interreference intervals, and interreference intervals (in days) appear to be more skewed than would occur with the Bernoulli process. Thus, about two-thirds of all sufficiently active files appear to be referenced as a renewal process with a skewed interreference distribution. A large number of other file reference statistics (file lifetimes, interference distributions, moments, means, number of uses/file, file sizes, file rates of reference, etc.) are computed and presented. The results are applied in the following paper to the development and comparative evaluation of file migration algorithms. 17 figures, 13 tables

  1. Reliability and maintainability data acquisition in equipment development tests

    International Nuclear Information System (INIS)

    Haire, M.J.; Gift, E.H.

    1983-10-01

    The need for collection of reliability, maintainability, and availability data adds a new dimension to the data acquisition requirements of equipment development tests. This report describes the reliability and maintainability data that are considered necessary to ensure that sufficient and high quality data exist for a comprehensive, quantitative evaluation of equipment and system availability. These necessary data are presented as a set of data collection forms. Three data acquisition forms are discussed: an inventory and technical data form, which is filed by the design engineer when the design is finished or the equipment is received; an event report form, which is completed by the senior test operator at each shutdown; and a maintainability report, which is a collaborative effort between senior operators and lead engineers and is completed on restart. In addition, elements of a reliability, maintainability evaluation program are described. Emphasis is placed on the role of data, its storage, and use in such a program

  2. JENDL special purpose file

    International Nuclear Information System (INIS)

    Nakagawa, Tsuneo

    1995-01-01

    In JENDL-3,2, the data on all the reactions having significant cross section over the neutron energy from 0.01 meV to 20 MeV are given for 340 nuclides. The object range of application extends widely, such as the neutron engineering, shield and others of fast reactors, thermal neutron reactors and nuclear fusion reactors. This is a general purpose data file. On the contrary to this, the file in which only the data required for a specific application field are collected is called special purpose file. The file for dosimetry is a typical special purpose file. The Nuclear Data Center, Japan Atomic Energy Research Institute, is making ten kinds of JENDL special purpose files. The files, of which the working groups of Sigma Committee are in charge, are listed. As to the format of the files, ENDF format is used similarly to JENDL-3,2. Dosimetry file, activation cross section file, (α, n) reaction data file, fusion file, actinoid file, high energy data file, photonuclear data file, PKA/KERMA file, gas production cross section file and decay data file are described on their contents, the course of development and their verification. Dosimetry file and gas production cross section file have been completed already. As for the others, the expected time of completion is shown. When these files are completed, they are opened to the public. (K.I.)

  3. 11 CFR 100.19 - File, filed or filing (2 U.S.C. 434(a)).

    Science.gov (United States)

    2010-01-01

    ... a facsimile machine or by electronic mail if the reporting entity is not required to file..., including electronic reporting entities, may use the Commission's website's on-line program to file 48-hour... the reporting entity is not required to file electronically in accordance with 11 CFR 104.18. [67 FR...

  4. Storage of sparse files using parallel log-structured file system

    Science.gov (United States)

    Bent, John M.; Faibish, Sorin; Grider, Gary; Torres, Aaron

    2017-11-07

    A sparse file is stored without holes by storing a data portion of the sparse file using a parallel log-structured file system; and generating an index entry for the data portion, the index entry comprising a logical offset, physical offset and length of the data portion. The holes can be restored to the sparse file upon a reading of the sparse file. The data portion can be stored at a logical end of the sparse file. Additional storage efficiency can optionally be achieved by (i) detecting a write pattern for a plurality of the data portions and generating a single patterned index entry for the plurality of the patterned data portions; and/or (ii) storing the patterned index entries for a plurality of the sparse files in a single directory, wherein each entry in the single directory comprises an identifier of a corresponding sparse file.

  5. Abnormal extraosseous activity in both lungs and stomach in pre-transplant 99mTc-MDP bone scan disappearing after renal transplant

    International Nuclear Information System (INIS)

    Sonavane, Sunita Tarsarya; Marwah, Atul; Jaiswar, Rajnath; Shah, Hardik

    2013-01-01

    A chronic kidney disease male patient presenting with bone pains, fever, weakness, and clinically ascites was subjected to four technetium-99m-methylene diphosphonate ( 99m Tc-MDP) bone scans, two before renal transplant and two after renal transplants. Pretransplant bone scan revealed metabolic bone disease with focal insufficiency fractures. Marked extraosseous activity in both lungs and stomach was also visualized. On regular hemodialysis (HD) after 4 months, repeat pretransplant bone scan showed persistent uptake in lungs and stomach, representing altered calcium metabolism with microcalcifications. He underwent human leukocyte antigen (HLA) matched live donor renal transplantation, started on immune-suppression and steroids. Posttransplant bone scan at 20 days revealed no definite interval change, but bone scan performed approximately 17 months posttransplant showed resolving metabolic bone disease and the tracer uptake in the lungs and stomach was no more visualized. Patient clinically followed-up until the date (February 2013) is asymptomatic with serum creatinine of 1.5 mg/dl, no bone scan done. (author)

  6. File Type Identification of File Fragments using Longest Common Subsequence (LCS)

    Science.gov (United States)

    Rahmat, R. F.; Nicholas, F.; Purnamawati, S.; Sitompul, O. S.

    2017-01-01

    Computer forensic analyst is a person in charge of investigation and evidence tracking. In certain cases, the file needed to be presented as digital evidence was deleted. It is difficult to reconstruct the file, because it often lost its header and cannot be identified while being restored. Therefore, a method is required for identifying the file type of file fragments. In this research, we propose Longest Common Subsequences that consists of three steps, namely training, testing and validation, to identify the file type from file fragments. From all testing results we can conlude that our proposed method works well and achieves 92.91% of accuracy to identify the file type of file fragment for three data types.

  7. 49 CFR 564.5 - Information filing; agency processing of filings.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 6 2010-10-01 2010-10-01 false Information filing; agency processing of filings... HIGHWAY TRAFFIC SAFETY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION REPLACEABLE LIGHT SOURCE INFORMATION (Eff. until 12-01-12) § 564.5 Information filing; agency processing of filings. (a) Each manufacturer...

  8. Cut-and-Paste file-systems: integrating simulators and file systems

    NARCIS (Netherlands)

    Bosch, H.G.P.; Mullender, Sape J.

    1995-01-01

    We have implemented an integrated and configurable file system called the Pegasus filesystem (PFS) and a trace-driven file-system simulator called Patsy. Patsy is used for off-line analysis of file-systemalgorithms, PFS is used for on-line file-systemdata storage. Algorithms are first analyzed in

  9. WebFTS: File Transfer Web Interface for FTS3

    CERN Multimedia

    CERN. Geneva

    2014-01-01

    WebFTS is a web-delivered file transfer and management solution which allows users to invoke reliable, managed data transfers on distributed infrastructures. The fully open source solution offers a simple graphical interface through which the power of the FTS3 service can be accessed without the installation of any special grid tools. Created following simplicity and efficiency criteria, WebFTS allows the user to access and interact with multiple grid and cloud storage. The “transfer engine” used is FTS3, the service responsible for distributing the majority of LHC data across WLCG infrastructure. This provides WebFTS with reliable, multi-protocol, adaptively optimised data transfers.The talk will focus on the recent development which allows transfers from/to Dropbox and CERNBox (CERN ownCloud deployment)

  10. Cut-and-Paste file-systems : integrating simulators and file systems

    NARCIS (Netherlands)

    Bosch, H.G.P.; Mullender, Sape J.

    1996-01-01

    We have implemented an integrated and configurable file system called the PFS and a trace-driven file-system simulator called Patsy. Patsy is used for off-line analysis of file-system algorithms, PFS is used for on-line file-system data storage. Algorithms are first analyzed in Patsy and when we are

  11. Comparison of Tc-99m Ciprofloxacin (Infecton) and Tc-99m Methylene diphosphonate (MDP) three-phase bone scintigraphy in the diagnosis of osteomyelitis in patients with Sickle Cell Disease

    International Nuclear Information System (INIS)

    Bererhi, H.; Hussein, S.; Wali, Y.

    2003-01-01

    The high incidence of Sickle Cell Disease (SCD) is a major health problem in Oman. These patients are more prone to infections than the general population, and in particular, they are highly susceptible to osteomyelitis. Because bone infarction is more common than osteomyelitis in SCD, an accurate and rapid differential diagnosis is essential before initiating appropriate treatment. The present prospective study evaluates the usefulness of the new radiopharmaceutical, Tc- 99m Ciprofloxacin (Infecton) for the differential diagnosis of infection and infarction in patients with SCD. Majority of subjects studied were children. The results of Tc-99m Infecton imaging were compared with those of the 3-phase bone scintigraphy using Tc- 99m Methylene diphosphonate (Tc-99m MDP). Twenty-five patients referred for ruling out infection were imaged after intravenous injection of 5.5 MBq/kg body weight of Tc-99m Infecton. First pass, blood pool and late images (at one, four and 24 hours post injection) were performed. Subsequently all patients were also studied by three-phase bone scintigraphy using Tc-99m MDP. No adverse effects were observed. The sensitivity, specificity, accuracy and positive likelihood ratio of Tc-99m Infecton imaging for osteomyelitis were 100%, 92%, 94% and 12.5 respectively. Although bone scintigraphy would rarely be used by itself as a stand-alone test in the diagnosis of osteomyelitis in patients with SCD, its corresponding values were: 88%, 64%, 71% and 2.4. The results of this study suggest that the use of Tc-99m Infecton imaging is extremely beneficial in the management of patients of Sickle Cell Disease with suspected osteomyelitis. (author)

  12. SU-F-T-233: Evaluation of Treatment Delivery Parameters Using High Resolution ELEKTA Log Files

    Energy Technology Data Exchange (ETDEWEB)

    Kabat, C; Defoor, D; Alexandrian, A; Papanikolaou, N; Stathakis, S [University of Texas HSC SA, San Antonio, TX (United States)

    2016-06-15

    Purpose: As modern linacs have become more technologically advanced with the implementation of IGRT and IMRT with HDMLCs, a requirement for more elaborate tracking techniques to monitor components’ integrity is paramount. ElektaLog files are generated every 40 milliseconds, which can be analyzed to track subtle changes and provide another aspect of quality assurance. This allows for constant monitoring of fraction consistency in addition to machine reliability. With this in mind, it was the aim of the study to evaluate if ElektaLog files can be utilized for linac consistency QA. Methods: ElektaLogs were reviewed for 16 IMRT patient plans with >16 fractions. Logs were analyzed by creating fluence maps from recorded values of MLC locations, jaw locations, and dose per unit time. Fluence maps were then utilized to calculate a 2D gamma index with a 2%–2mm criteria for each fraction. ElektaLogs were also used to analyze positional errors for MLC leaves and jaws, which were used to compute an overall error for the MLC banks, Y-jaws, and X-jaws by taking the root-meansquare value of the individual recorded errors during treatment. Additionally, beam on time was calculated using the number of ElektaLog file entries within the file. Results: The average 2D gamma for all 16 patient plans was found to be 98.0±2.0%. Recorded gamma index values showed an acceptable correlation between fractions. Average RMS values for MLC leaves and the jaws resulted in a leaf variation of roughly 0.3±0.08 mm and jaw variation of about 0.15±0.04 mm, both of which fall within clinical tolerances. Conclusion: The use of ElektaLog files for day-to-day evaluation of linac integrity and patient QA can be utilized to allow for reliable analysis of system accuracy and performance.

  13. SU-F-T-233: Evaluation of Treatment Delivery Parameters Using High Resolution ELEKTA Log Files

    International Nuclear Information System (INIS)

    Kabat, C; Defoor, D; Alexandrian, A; Papanikolaou, N; Stathakis, S

    2016-01-01

    Purpose: As modern linacs have become more technologically advanced with the implementation of IGRT and IMRT with HDMLCs, a requirement for more elaborate tracking techniques to monitor components’ integrity is paramount. ElektaLog files are generated every 40 milliseconds, which can be analyzed to track subtle changes and provide another aspect of quality assurance. This allows for constant monitoring of fraction consistency in addition to machine reliability. With this in mind, it was the aim of the study to evaluate if ElektaLog files can be utilized for linac consistency QA. Methods: ElektaLogs were reviewed for 16 IMRT patient plans with >16 fractions. Logs were analyzed by creating fluence maps from recorded values of MLC locations, jaw locations, and dose per unit time. Fluence maps were then utilized to calculate a 2D gamma index with a 2%–2mm criteria for each fraction. ElektaLogs were also used to analyze positional errors for MLC leaves and jaws, which were used to compute an overall error for the MLC banks, Y-jaws, and X-jaws by taking the root-meansquare value of the individual recorded errors during treatment. Additionally, beam on time was calculated using the number of ElektaLog file entries within the file. Results: The average 2D gamma for all 16 patient plans was found to be 98.0±2.0%. Recorded gamma index values showed an acceptable correlation between fractions. Average RMS values for MLC leaves and the jaws resulted in a leaf variation of roughly 0.3±0.08 mm and jaw variation of about 0.15±0.04 mm, both of which fall within clinical tolerances. Conclusion: The use of ElektaLog files for day-to-day evaluation of linac integrity and patient QA can be utilized to allow for reliable analysis of system accuracy and performance.

  14. The clinical value of "9"9Tc"m-MDP whole body bone imaging in diagnosing bone metastasis of lung cancer

    International Nuclear Information System (INIS)

    Zhao Yigang; Gou Zhengxing

    2016-01-01

    Objective: To discuss the clinical value of whole body bone imaging on lung cancer bone metastases diagnosis, so as to evaluate the staging of lung cancer patients. Methods: A total of 113 cases of patients diagnosed with lung cancer received whole body imaging, alkaline phosphatase and blood calcium examination. Bone metastasis probability of lung cancer was assessed based on different pathological types. Accuracy rates of bone metastases was compared by whole body bone imaging and suspicious bone metastasis factors (Including one or several items in ostalgia, alkaline phosphatase rising and hypercalcemia). Results The occurrence rate of lung cancer bone metastasis is 36.7%, and the bone metastasis occurrence rate of adenocarcinoma of lung is higher than that of squamous cell lung carcinoma (P < 0.01). Whole body Imaging diagnose of lung cancer bone metastases had sensitivity (92.7%), specificity (83.2%) and accuracy (85.7%). Conclusion: "9"9Tc"m-MDP whole body imaging is a highly sensitive tool to review whole body bone. Lung cancer patients are recommended to receive routine whole body bone imaging. (authors)

  15. File sharing

    NARCIS (Netherlands)

    van Eijk, N.

    2011-01-01

    File sharing’ has become generally accepted on the Internet. Users share files for downloading music, films, games, software etc. In this note, we have a closer look at the definition of file sharing, the legal and policy-based context as well as enforcement issues. The economic and cultural

  16. How informed is consent in vulnerable populations? Experience using a continuous consent process during the MDP301 vaginal microbicide trial in Mwanza, Tanzania

    Directory of Open Access Journals (Sweden)

    Kavit Natujwa

    2010-06-01

    Full Text Available Abstract Background HIV prevention trials conducted among disadvantaged vulnerable at-risk populations in developing countries present unique ethical dilemmas. A key concern in bioethics is the validity of informed consent for trial participation obtained from research subjects in such settings. The purpose of this study was to investigate the effectiveness of a continuous informed consent process adopted during the MDP301 phase III vaginal microbicide trial in Mwanza, Tanzania. Methods A total of 1146 women at increased risk of HIV acquisition working as alcohol and food vendors or in bars, restaurants, hotels and guesthouses have been recruited into the MDP301 phase III efficacy and safety trial in Mwanza. During preparations for the trial, participatory community research methods were used to develop a locally-appropriate pictorial flipchart in order to convey key messages about the trial to potential participants. Pre-recorded audio tapes were also developed to facilitate understanding and compliance with gel-use instructions. A comprehension checklist is administered by clinical staff to all participants at screening, enrolment, 12, 24, 40 and 50 week follow-up visits during the trial. To investigate women's perceptions and experiences of the trial, including how well participants internalize and retain key messages provided through a continuous informed consent process, a random sub-sample of 102 women were invited to participate in in-depth interviews (IDIs conducted immediately after their 4, 24 and 52 week follow-up visits. Results 99 women completed interviews at 4-weeks, 83 at 24-weeks, and 74 at 52 weeks (a total of 256 interviews. In all interviews there was evidence of good comprehension and retention of key trial messages including that the gel is not currently know to be effective against HIV; that this is the key reason for conducting the trial; and that women should stop using gel in the event of pregnancy. Conclusions

  17. Hierarchical remote data possession checking method based on massive cloud files

    Directory of Open Access Journals (Sweden)

    Ma Haifeng

    2017-06-01

    Full Text Available Cloud storage service enables users to migrate their data and applications to the cloud, which saves the local data maintenance and brings great convenience to the users. But in cloud storage, the storage servers may not be fully trustworthy. How to verify the integrity of cloud data with lower overhead for users has become an increasingly concerned problem. Many remote data integrity protection methods have been proposed, but these methods authenticated cloud files one by one when verifying multiple files. Therefore, the computation and communication overhead are still high. Aiming at this problem, a hierarchical remote data possession checking (hierarchical-remote data possession checking (H-RDPC method is proposed, which can provide efficient and secure remote data integrity protection and can support dynamic data operations. This paper gives the algorithm descriptions, security, and false negative rate analysis of H-RDPC. The security analysis and experimental performance evaluation results show that the proposed H-RDPC is efficient and reliable in verifying massive cloud files, and it has 32–81% improvement in performance compared with RDPC.

  18. Polarographic determination of Sn (II) and total Sn in PYRO and MDP radiopharmaceutical kits

    International Nuclear Information System (INIS)

    Sebastian, Maria V.A.; Lugon, Marcelo Di M.V.; Silva, Jose L. da; Fukumori, Neuza T.O.; Pereira, Nilda P.S. de; Silva, Constancia P.G. da; Matsuda, Margareth M.N.

    2007-01-01

    A sensitive, alternative method to atom absorption spectrometry, fluorimetry or potentiometry for the evaluation of tin(II) ions (0.1- 10 mg) and total tin in radiopharmaceutical kits was investigated. Differential pulse polarography was chosen. The supporting electrolyte was H 2 SO 4 3 mol L -1 and HCl 3 mol L -1 solution. The potential was swept from -250 to -800 mV vs Ag/AgCl/saturated KCl, using a dropping mercury electrode with 1 s drop time, 50 mV s -1 scan rate, -50 mV pulse amplitude, 40 ms pulse time and 10 mV step amplitude. Pure nitrogen was used to deaerate the polarographic cell solution for 5 min, before and after each sample introduction. Oxidation of Sn(II) was made in the same sample vial by adding H 2 O 2 (hydrogen peroxide) 10 mol L -1 , at 37 deg C, in order to quantify the total Sn. The calibration curve for Sn(II) and Sn(IV) was obtained in the concentration range of 0-10 ppm from a 1000 ppm standard solution. The detection limit of Sn(II) is 0.5 ppm and for Sn(IV) is 0.6 ppm. Differential pulse polarography was performed in the pyrophosphate (PYRO) and methylenediphosphonic acid (MDP) radiopharmaceutical kits, containing 2 mg and 1 mg of SnCl 2 .2H 2 O per vial, respectively. The described method for determination of stannous ion (Sn(II)), is selective, reproducible and adequate to be used in the quality control of lyophilized reagents and it shall be performed for other cold kits produced at IPEN. (author)

  19. Renewal-anomalous-heterogeneous files

    International Nuclear Information System (INIS)

    Flomenbom, Ophir

    2010-01-01

    Renewal-anomalous-heterogeneous files are solved. A simple file is made of Brownian hard spheres that diffuse stochastically in an effective 1D channel. Generally, Brownian files are heterogeneous: the spheres' diffusion coefficients are distributed and the initial spheres' density is non-uniform. In renewal-anomalous files, the distribution of waiting times for individual jumps is not exponential as in Brownian files, yet obeys: ψ α (t)∼t -1-α , 0 2 >, obeys, 2 >∼ 2 > nrml α , where 2 > nrml is the MSD in the corresponding Brownian file. This scaling is an outcome of an exact relation (derived here) connecting probability density functions of Brownian files and renewal-anomalous files. It is also shown that non-renewal-anomalous files are slower than the corresponding renewal ones.

  20. PC Graphic file programing

    International Nuclear Information System (INIS)

    Yang, Jin Seok

    1993-04-01

    This book gives description of basic of graphic knowledge and understanding and realization of graphic file form. The first part deals with graphic with graphic data, store of graphic data and compress of data, programing language such as assembling, stack, compile and link of program and practice and debugging. The next part mentions graphic file form such as Mac paint file, GEM/IMG file, PCX file, GIF file, and TIFF file, consideration of hardware like mono screen driver and color screen driver in high speed, basic conception of dithering and conversion of formality.

  1. On Hybrid Energy Utilization in Wireless Sensor Networks

    Directory of Open Access Journals (Sweden)

    Mohammad Tala’t

    2017-11-01

    Full Text Available In a wireless sensor network (WSN, many applications have limited energy resources for data transmission. In order to accomplish a better green communication for WSN, a hybrid energy scheme can supply a more reliable energy source. In this article, hybrid energy utilization—which consists of constant energy source and solar harvested energy—is considered for WSN. To minimize constant energy usage from the hybrid source, a Markov decision process (MDP is designed to find the optimal transmission policy. With a finite packet buffer and a finite battery size, an MDP model is presented to define the states, actions, state transition probabilities, and the cost function including the cost values for all actions. A weighted sum of constant energy source consumption and a packet dropping probability (PDP are adopted as the cost value, enabling us to find the optimal solution for balancing the minimization of the constant energy source utilization and the PDP using a value iteration algorithm. As shown in the simulation results, the performance of optimal solution using MDP achieves a significant improvement compared to solution without its use.

  2. Reliability of emergency ac power systems at nuclear power plants

    International Nuclear Information System (INIS)

    Battle, R.E.; Campbell, D.J.

    1983-07-01

    Reliability of emergency onsite ac power systems at nuclear power plants has been questioned within the Nuclear Regulatory Commission (NRC) because of the number of diesel generator failures reported by nuclear plant licensees and the reactor core damage that could result from diesel failure during an emergency. This report contains the results of a reliability analysis of the onsite ac power system, and it uses the results of a separate analysis of offsite power systems to calculate the expected frequency of station blackout. Included is a design and operating experience review. Eighteen plants representative of typical onsite ac power systems and ten generic designs were selected to be modeled by fault trees. Operating experience data were collected from the NRC files and from nuclear plant licensee responses to a questionnaire sent out for this project

  3. Experiences on File Systems: Which is the best file system for you?

    CERN Document Server

    Blomer, J

    2015-01-01

    The distributed file system landscape is scattered. Besides a plethora of research file systems, there is also a large number of production grade file systems with various strengths and weaknesses. The file system, as an abstraction of permanent storage, is appealing because it provides application portability and integration with legacy and third-party applications, including UNIX utilities. On the other hand, the general and simple file system interface makes it notoriously difficult for a distributed file system to perform well under a variety of different workloads. This contribution provides a taxonomy of commonly used distributed file systems and points out areas of research and development that are particularly important for high-energy physics.

  4. Storing files in a parallel computing system using list-based index to identify replica files

    Science.gov (United States)

    Faibish, Sorin; Bent, John M.; Tzelnic, Percy; Zhang, Zhenhua; Grider, Gary

    2015-07-21

    Improved techniques are provided for storing files in a parallel computing system using a list-based index to identify file replicas. A file and at least one replica of the file are stored in one or more storage nodes of the parallel computing system. An index for the file comprises at least one list comprising a pointer to a storage location of the file and a storage location of the at least one replica of the file. The file comprises one or more of a complete file and one or more sub-files. The index may also comprise a checksum value for one or more of the file and the replica(s) of the file. The checksum value can be evaluated to validate the file and/or the file replica(s). A query can be processed using the list.

  5. PCF File Format.

    Energy Technology Data Exchange (ETDEWEB)

    Thoreson, Gregory G [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)

    2017-08-01

    PCF files are binary files designed to contain gamma spectra and neutron count rates from radiation sensors. It is the native format for the GAmma Detector Response and Analysis Software (GADRAS) package [1]. It can contain multiple spectra and information about each spectrum such as energy calibration. This document outlines the format of the file that would allow one to write a computer program to parse and write such files.

  6. Provider of Services File

    Data.gov (United States)

    U.S. Department of Health & Human Services — The POS file consists of two data files, one for CLIA labs and one for 18 other provider types. The file names are CLIA and OTHER. If downloading the file, note it...

  7. Alternative Estimates of the Reliability of College Grade Point Averages. Professional File. Article 130, Spring 2013

    Science.gov (United States)

    Saupe, Joe L.; Eimers, Mardy T.

    2013-01-01

    The purpose of this paper is to explore differences in the reliabilities of cumulative college grade point averages (GPAs), estimated for unweighted and weighted, one-semester, 1-year, 2-year, and 4-year GPAs. Using cumulative GPAs for a freshman class at a major university, we estimate internal consistency (coefficient alpha) reliabilities for…

  8. Multiobjective Reliable Cloud Storage with Its Particle Swarm Optimization Algorithm

    Directory of Open Access Journals (Sweden)

    Xiyang Liu

    2016-01-01

    Full Text Available Information abounds in all fields of the real life, which is often recorded as digital data in computer systems and treated as a kind of increasingly important resource. Its increasing volume growth causes great difficulties in both storage and analysis. The massive data storage in cloud environments has significant impacts on the quality of service (QoS of the systems, which is becoming an increasingly challenging problem. In this paper, we propose a multiobjective optimization model for the reliable data storage in clouds through considering both cost and reliability of the storage service simultaneously. In the proposed model, the total cost is analyzed to be composed of storage space occupation cost, data migration cost, and communication cost. According to the analysis of the storage process, the transmission reliability, equipment stability, and software reliability are taken into account in the storage reliability evaluation. To solve the proposed multiobjective model, a Constrained Multiobjective Particle Swarm Optimization (CMPSO algorithm is designed. At last, experiments are designed to validate the proposed model and its solution PSO algorithm. In the experiments, the proposed model is tested in cooperation with 3 storage strategies. Experimental results show that the proposed model is positive and effective. The experimental results also demonstrate that the proposed model can perform much better in alliance with proper file splitting methods.

  9. Text File Comparator

    Science.gov (United States)

    Kotler, R. S.

    1983-01-01

    File Comparator program IFCOMP, is text file comparator for IBM OS/VScompatable systems. IFCOMP accepts as input two text files and produces listing of differences in pseudo-update form. IFCOMP is very useful in monitoring changes made to software at the source code level.

  10. Status and evaluation methods of JENDL fusion file and JENDL PKA/KERMA file

    International Nuclear Information System (INIS)

    Chiba, S.; Fukahori, T.; Shibata, K.; Yu Baosheng; Kosako, K.

    1997-01-01

    The status of evaluated nuclear data in the JENDL fusion file and PKA/KERMA file is presented. The JENDL fusion file was prepared in order to improve the quality of the JENDL-3.1 data especially on the double-differential cross sections (DDXs) of secondary neutrons and gamma-ray production cross sections, and to provide DDXs of secondary charged particles (p, d, t, 3 He and α-particle) for the calculation of PKA and KERMA factors. The JENDL fusion file contains evaluated data of 26 elements ranging from Li to Bi. The data in JENDL fusion file reproduce the measured data on neutron and charged-particle DDXs and also on gamma-ray production cross sections. Recoil spectra in PKA/KERMA file were calculated from secondary neutron and charged-particle DDXs contained in the fusion file with two-body reaction kinematics. The data in the JENDL fusion file and PKA/KERMA file were compiled in ENDF-6 format with an MF=6 option to store the DDX data. (orig.)

  11. Establishment of an experimental human lung adenocarcinoma cell line SPC-A-1BM with high bone metastases potency by 99mTc-MDP bone scintigraphy

    International Nuclear Information System (INIS)

    Yang Shunfang; Dong Qianggang; Yao Ming; Shi Meiping; Ye Jianding; Zhao Langxiang; Su Jianzhong; Gu Weiyong; Xie Wenhui; Wang Kankan; Du Yanzhi; Li Yao; Huang Yan

    2009-01-01

    Background: Bone metastasis is one of the most common clinical phenomena of late stage lung cancer. A major impediment to understanding the pathogenesis of bone metastasis has been the lack of an appropriate animal and cell model. This study aims to establish human lung adenocarcinoma cell line with highly bone metastases potency with 99m Tc-MDP bone scintigraphy. Methods: The human lung adenocarcinoma cancer cells SPC-A-1 were injected into the left cardiac ventricle of NIH-Beige-Nude-XID (NIH-BNX) immunodeficient mice. The metastatic lesions of tumor-bearing mice were imaged with 99m Tc-MDP bone scintigraphy on a Siemens multi-single photon emission computed tomography. Pinhole images were acquired on a GZ-B conventional gamma camera with a self-designed pinhole collimator. The mice with bone metastasis were sacrificed under deep anesthesia, and the lesions were resected. Bone metastatic cancer cells in the resected lesions were subjected for culture and then reinoculated into the NIH-BNX mice through left cardiac ventricle. The process was repeated for eight cycles to obtain a novel cell subline SPC-A-1BM. Real-time polymerase chain reaction (PCR) was used to compare the gene expression differences in the parental and SPC-A-1BM cells. Results: The bone metastasis sites were successfully revealed by bone scintigraphy. The established bone metastasis cell line SPC-A-1BM had a high potential to metastasize in bone, including mandible, humerus, thoracic vertebra, lumbar, femur, patella, ilium and cartilage rib. The expression level of vascular endothelial growth factor gene family, Bcl-2 and cell adhesion-related genes ECM1, ESM1, AF1Q, SERPINE2 and FN1 were examined. Gene expression difference was found between parental and bone-seeking metastasis cell SPC-A-1BM, which indicates SPC-A-1BM has metastatic capacity vs. its parental cells. Conclusion: SPC-A-1BM is a bone-seeking metastasis human lung adenocarcinoma cell line. Bone scintigraphy may be used as an

  12. JENDL dosimetry file 99 (JENDL/D-99)

    International Nuclear Information System (INIS)

    Kobayashi, Katsuhei; Iwasaki, Shin

    2002-01-01

    The JENDL Dosimetry File 99 (JENDL/D-99), which is a revised version of the JENDL Dosimetry File 91 (JENDL/D-91), has been compiled and released for the determination of neutron flux and energy spectra. This work was undertaken to remove the inconsistency between the cross sections and their covariances in JENDL/D-91 since the covariances were mainly taken from IRDF-85 although the cross sections were based on JENDL-3. Dosimetry cross sections have been evaluated for 67 reactions on 47 nuclides together with covariances. The cross sections for 34 major reactions and their covariances were simultaneously generated, and the remaining 33 reaction data were mainly taken from JENDL/D-91. Latest measurements were taken into account in the evaluation. The resultant evaluated data are given in the neutron energy region below 20 MeV in both of point-wise and group-wise files in the ENDF-6 format. In order to confirm the reliability of the evaluated data, several integral tests have been carried out: comparisons with average cross sections measured in fission neutron fields, fast/thermal reactor spectra, DT neutron fields and Li(d,n) neutron fields. It was found from the comparisons that the cross sections calculated from JENDL/D-99 are generally in good agreement with the measured data. The contents of JENDL/D-99 and the results of the integral tests are described in this report. All of the dosimetry cross sections are shown in a graphical form in the Appendix. (author)

  13. Growth arrest line mimicking lymphoma involvement: The findings of 99mTc-MDP bone SPECT/CT and serial bone scan in a child with non-Hodgkin's lymphoma

    International Nuclear Information System (INIS)

    Kim, Chan Woo; Kim, Ji Young; Choi, Yun Young; Lee, Seung Hun; Lee, Young Ho

    2016-01-01

    Growth arrest lines appear as dense sclerotic lines parallel to the growth plate of long bones on radiography. We describe the case of a 9-year-old female with growth arrest lines initially masquerading as lymphoma involvement on 99m Tc-MDP bone scintigraphy who had been treated with chemotherapy for non-Hodgkin's lymphoma about 3 years previously. Subsequent regional bone SPECT/CT clearly diagnosed the growth arrest lines, and retrograde review of previous bone scintigraphy demonstrated line migration in this patient. Growth arrest lines should be considered a possible diagnosis on bone scintigraphy, especially in the surveillance of children who have experienced severe childhood infections, malnutrition, immobilization, or treatment with immunosuppressive or chemotherapeutic drugs that may inhibit bone growth

  14. Securing the AliEn File Catalogue - Enforcing authorization with accountable file operations

    International Nuclear Information System (INIS)

    Schreiner, Steffen; Banerjee, Subho Sankar; Betev, Latchezar; Carminati, Federico; Vladimirovna Datskova, Olga; Furano, Fabrizio; Grigoras, Alina; Grigoras, Costin; Mendez Lorenzo, Patricia; Peters, Andreas Joachim; Saiz, Pablo; Bagnasco, Stefano; Zhu Jianlin

    2011-01-01

    The AliEn Grid Services, as operated by the ALICE Collaboration in its global physics analysis grid framework, is based on a central File Catalogue together with a distributed set of storage systems and the possibility to register links to external data resources. This paper describes several identified vulnerabilities in the AliEn File Catalogue access protocol regarding fraud and unauthorized file alteration and presents a more secure and revised design: a new mechanism, called LFN Booking Table, is introduced in order to keep track of access authorization in the transient state of files entering or leaving the File Catalogue. Due to a simplification of the original Access Envelope mechanism for xrootd-protocol-based storage systems, fundamental computational improvements of the mechanism were achieved as well as an up to 50% reduction of the credential's size. By extending the access protocol with signed status messages from the underlying storage system, the File Catalogue receives trusted information about a file's size and checksum and the protocol is no longer dependent on client trust. Altogether, the revised design complies with atomic and consistent transactions and allows for accountable, authentic, and traceable file operations. This paper describes these changes as part and beyond the development of AliEn version 2.19.

  15. HUD GIS Boundary Files

    Data.gov (United States)

    Department of Housing and Urban Development — The HUD GIS Boundary Files are intended to supplement boundary files available from the U.S. Census Bureau. The files are for community planners interested in...

  16. Keemei: cloud-based validation of tabular bioinformatics file formats in Google Sheets.

    Science.gov (United States)

    Rideout, Jai Ram; Chase, John H; Bolyen, Evan; Ackermann, Gail; González, Antonio; Knight, Rob; Caporaso, J Gregory

    2016-06-13

    first used with a bioinformatics system. Simplifying the validation of essential tabular data files, such as sample metadata, will reduce common errors and thereby improve the quality and reliability of research outcomes.

  17. The NUCLARR databank: Human reliability and hardware failure data for the nuclear power industry

    International Nuclear Information System (INIS)

    Reece, W.J.

    1993-01-01

    Under the sponsorship of the US Nuclear Regulatory Commission (NRC), the Nuclear Computerized Library for Assessing Reactor Reliability (NUCLARR) was developed to provide human reliability and hardware failure data to analysts in the nuclear power industry. This IBM-compatible databank is contained on a set of floppy diskettes which include data files and a menu-driven system for locating, reviewing, sorting, and retrieving the data. NUCLARR contains over 2500 individual data records, drawn from more, than 60 sources. The system is upgraded annually, to include additional human error and hardware component failure data and programming enhancements (i.e., increased user-friendliness). NUCLARR is available from the NRC through project staff at the INEL

  18. Malingering in Toxic Exposure. Classification Accuracy of Reliable Digit Span and WAIS-III Digit Span Scaled Scores

    Science.gov (United States)

    Greve, Kevin W.; Springer, Steven; Bianchini, Kevin J.; Black, F. William; Heinly, Matthew T.; Love, Jeffrey M.; Swift, Douglas A.; Ciota, Megan A.

    2007-01-01

    This study examined the sensitivity and false-positive error rate of reliable digit span (RDS) and the WAIS-III Digit Span (DS) scaled score in persons alleging toxic exposure and determined whether error rates differed from published rates in traumatic brain injury (TBI) and chronic pain (CP). Data were obtained from the files of 123 persons…

  19. 33 CFR 148.246 - When is a document considered filed and where should I file it?

    Science.gov (United States)

    2010-07-01

    ... filed and where should I file it? 148.246 Section 148.246 Navigation and Navigable Waters COAST GUARD... Formal Hearings § 148.246 When is a document considered filed and where should I file it? (a) If a document to be filed is submitted by mail, it is considered filed on the date it is postmarked. If a...

  20. Protecting your files on the DFS file system

    CERN Multimedia

    Computer Security Team

    2011-01-01

    The Windows Distributed File System (DFS) hosts user directories for all NICE users plus many more data.    Files can be accessed from anywhere, via a dedicated web portal (http://cern.ch/dfs). Due to the ease of access to DFS with in CERN it is of utmost importance to properly protect access to sensitive data. As the use of DFS access control mechanisms is not obvious to all users, passwords, certificates or sensitive files might get exposed. At least this happened in past to the Andrews File System (AFS) - the Linux equivalent to DFS) - and led to bad publicity due to a journalist accessing supposedly "private" AFS folders (SonntagsZeitung 2009/11/08). This problem does not only affect the individual user but also has a bad impact on CERN's reputation when it comes to IT security. Therefore, all departments and LHC experiments agreed recently to apply more stringent protections to all DFS user folders. The goal of this data protection policy is to assist users in pro...

  1. Protecting your files on the AFS file system

    CERN Multimedia

    2011-01-01

    The Andrew File System is a world-wide distributed file system linking hundreds of universities and organizations, including CERN. Files can be accessed from anywhere, via dedicated AFS client programs or via web interfaces that export the file contents on the web. Due to the ease of access to AFS it is of utmost importance to properly protect access to sensitive data in AFS. As the use of AFS access control mechanisms is not obvious to all users, passwords, private SSH keys or certificates have been exposed in the past. In one specific instance, this also led to bad publicity due to a journalist accessing supposedly "private" AFS folders (SonntagsZeitung 2009/11/08). This problem does not only affect the individual user but also has a bad impact on CERN's reputation when it comes to IT security. Therefore, all departments and LHC experiments agreed in April 2010 to apply more stringent folder protections to all AFS user folders. The goal of this data protection policy is to assist users in...

  2. Zebra: A striped network file system

    Science.gov (United States)

    Hartman, John H.; Ousterhout, John K.

    1992-01-01

    The design of Zebra, a striped network file system, is presented. Zebra applies ideas from log-structured file system (LFS) and RAID research to network file systems, resulting in a network file system that has scalable performance, uses its servers efficiently even when its applications are using small files, and provides high availability. Zebra stripes file data across multiple servers, so that the file transfer rate is not limited by the performance of a single server. High availability is achieved by maintaining parity information for the file system. If a server fails its contents can be reconstructed using the contents of the remaining servers and the parity information. Zebra differs from existing striped file systems in the way it stripes file data: Zebra does not stripe on a per-file basis; instead it stripes the stream of bytes written by each client. Clients write to the servers in units called stripe fragments, which are analogous to segments in an LFS. Stripe fragments contain file blocks that were written recently, without regard to which file they belong. This method of striping has numerous advantages over per-file striping, including increased server efficiency, efficient parity computation, and elimination of parity update.

  3. Growth arrest line mimicking lymphoma involvement: The findings of {sup 99m}Tc-MDP bone SPECT/CT and serial bone scan in a child with non-Hodgkin's lymphoma

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Chan Woo; Kim, Ji Young; Choi, Yun Young; Lee, Seung Hun; Lee, Young Ho [Hanyang University Medical Center, Seoul (Korea, Republic of)

    2016-06-15

    Growth arrest lines appear as dense sclerotic lines parallel to the growth plate of long bones on radiography. We describe the case of a 9-year-old female with growth arrest lines initially masquerading as lymphoma involvement on {sup 99m}Tc-MDP bone scintigraphy who had been treated with chemotherapy for non-Hodgkin's lymphoma about 3 years previously. Subsequent regional bone SPECT/CT clearly diagnosed the growth arrest lines, and retrograde review of previous bone scintigraphy demonstrated line migration in this patient. Growth arrest lines should be considered a possible diagnosis on bone scintigraphy, especially in the surveillance of children who have experienced severe childhood infections, malnutrition, immobilization, or treatment with immunosuppressive or chemotherapeutic drugs that may inhibit bone growth.

  4. A File Archival System

    Science.gov (United States)

    Fanselow, J. L.; Vavrus, J. L.

    1984-01-01

    ARCH, file archival system for DEC VAX, provides for easy offline storage and retrieval of arbitrary files on DEC VAX system. System designed to eliminate situations that tie up disk space and lead to confusion when different programers develop different versions of same programs and associated files.

  5. Assessment of feasibility of running RSNA's MIRC on a Raspberry Pi: a cost-effective solution for teaching files in radiology.

    Science.gov (United States)

    Pereira, Andre; Atri, Mostafa; Rogalla, Patrik; Huynh, Thien; O'Malley, Martin E

    2015-11-01

    The value of a teaching case repository in radiology training programs is immense. The allocation of resources for putting one together is a complex issue, given the factors that have to be coordinated: hardware, software, infrastructure, administration, and ethics. Costs may be significant and cost-effective solutions are desirable. We chose Medical Imaging Resource Center (MIRC) to build our teaching file. It is offered by RSNA for free. For the hardware, we chose the Raspberry Pi, developed by the Raspberry Foundation: a small control board developed as a low cost computer for schools also used in alternative projects such as robotics and environmental data collection. Its performance and reliability as a file server were unknown to us. For the operational system, we chose Raspbian, a variant of Debian Linux, along with Apache (web server), MySql (database server) and PHP, which enhance the functionality of the server. A USB hub and an external hard drive completed the setup. Installation of software was smooth. The Raspberry Pi was able to handle very well the task of hosting the teaching file repository for our division. Uptime was logged at 100 %, and loading times were similar to other MIRC sites available online. We setup two servers (one for backup), each costing just below $200.00 including external storage and USB hub. It is feasible to run RSNA's MIRC off a low-cost control board (Raspberry Pi). Performance and reliability are comparable to full-size servers for the intended purpose of hosting a teaching file within an intranet environment.

  6. Comparative evaluation of debris extruded apically by using, Protaper retreatment file, K3 file and H-file with solvent in endodontic retreatment

    Directory of Open Access Journals (Sweden)

    Chetna Arora

    2012-01-01

    Full Text Available Aim: The aim of this study was to evaluate the apical extrusion of debris comparing 2 engine driven systems and hand instrumentation technique during root canal retreatment. Materials and Methods: Forty five human permanent mandibular premolars were prepared using the step-back technique, obturated with gutta-percha/zinc oxide eugenol sealer and cold lateral condensation technique. The teeth were divided into three groups: Group A: Protaper retreatment file, Group B: K3, file Group C: H-file with tetrachloroethylene. All the canals were irrigated with 20ml distilled water during instrumentation. Debris extruded along with the irrigating solution during retreatment procedure was carefully collected in preweighed Eppendorf tubes. The tubes were stored in an incubator for 5 days, placed in a desiccator and then re-weighed. Weight of dry debris was calculated by subtracting the weight of the tube before instrumentation and from the weight of the tube after instrumentation. Data was analyzed using Two Way ANOVA and Post Hoc test. Results : There was statistically significant difference in the apical extrusion of debris between hand instrumentation and protaper retreatment file and K3 file. The amount of extruded debris caused by protaper retreatment file and K3 file instrumentation technique was not statistically significant. All the three instrumentation techniques produced apically extruded debris and irrigant. Conclusion: The best way to minimize the extrusion of debris is by adapting crown down technique therefore the use of rotary technique (Protaper retreatment file, K3 file is recommended.

  7. Computer Forensics Method in Analysis of Files Timestamps in Microsoft Windows Operating System and NTFS File System

    Directory of Open Access Journals (Sweden)

    Vesta Sergeevna Matveeva

    2013-02-01

    Full Text Available All existing file browsers displays 3 timestamps for every file in file system NTFS. Nowadays there are a lot of utilities that can manipulate temporal attributes to conceal the traces of file using. However every file in NTFS has 8 timestamps that are stored in file record and used in detecting the fact of attributes substitution. The authors suggest a method of revealing original timestamps after replacement and automated variant of it in case of a set of files.

  8. 76 FR 43679 - Filing via the Internet; Notice of Additional File Formats for efiling

    Science.gov (United States)

    2011-07-21

    ... list of acceptable file formats the four-character file extensions for Microsoft Office 2007/2010... files from Office 2007 or Office 2010 in an Office 2003 format prior to submission. Dated: July 15, 2011...

  9. UPIN Group File

    Data.gov (United States)

    U.S. Department of Health & Human Services — The Group Unique Physician Identifier Number (UPIN) File is the business entity file that contains the group practice UPIN and descriptive information. It does NOT...

  10. Interoperability format translation and transformation between IFC architectural design file and simulation file formats

    Science.gov (United States)

    Chao, Tian-Jy; Kim, Younghun

    2015-01-06

    Automatically translating a building architecture file format (Industry Foundation Class) to a simulation file, in one aspect, may extract data and metadata used by a target simulation tool from a building architecture file. Interoperability data objects may be created and the extracted data is stored in the interoperability data objects. A model translation procedure may be prepared to identify a mapping from a Model View Definition to a translation and transformation function. The extracted data may be transformed using the data stored in the interoperability data objects, an input Model View Definition template, and the translation and transformation function to convert the extracted data to correct geometric values needed for a target simulation file format used by the target simulation tool. The simulation file in the target simulation file format may be generated.

  11. Role of Muramyl Dipeptide in Lipopolysaccharide-Mediated Biological Activity and Osteoclast Activity

    Directory of Open Access Journals (Sweden)

    Hideki Kitaura

    2018-01-01

    Full Text Available Lipopolysaccharide (LPS is an endotoxin and bacterial cell wall component that is capable of inducing inflammation and immunological activity. Muramyl dipeptide (MDP, the minimal essential structural unit responsible for the immunological activity of peptidoglycans, is another inflammation-inducing molecule that is ubiquitously expressed by bacteria. Several studies have shown that inflammation-related biological activities were synergistically induced by interactions between LPS and MDP. MDP synergistically enhances production of proinflammatory cytokines that are induced by LPS exposure. Injection of MDP induces lethal shock in mice challenged with LPS. LPS also induces osteoclast formation and pathological bone resorption; MDP enhances LPS induction of both processes. Furthermore, MDP enhances the LPS-induced receptor activator of NF-κB ligand (RANKL expression and toll-like receptor 4 (TLR4 expression both in vivo and in vitro. Additionally, MDP enhances LPS-induced mitogen-activated protein kinase (MAPK signaling in stromal cells. Taken together, these findings suggest that MDP plays an important role in LPS-induced biological activities. This review discusses the role of MDP in LPS-mediated biological activities, primarily in relation to osteoclastogenesis.

  12. Whole body retention of Tc-99m Methylene Diphosphonate (MDP) in monitoring skeletal calcium status in post-menopausal women

    International Nuclear Information System (INIS)

    Patel, R.B.; Rangarajan, V.; Samuel, A.M.; Joshi, D.P.; Ray, S.; Raste, A.S.; Gadhre

    2003-01-01

    The detection and estimation of skeletal calcium loss has become an important consideration in the management of post-menopausal women. The need to supplement large amounts of calcium of 1000-1500 mg per day is recommended to forestall the risk of skeletal fractures. The added supplementation of estrogens and progesterone for several years is also recommended to prevent bone calcium loss. The need to record the calcium status in post-menopausal women is becoming necessary in the present scenario. A total of 159 women in the peri-menopausal, menopausal and post-menopausal groups were selected. None of them had other systemic diseases. They were healthy and not on any medication. They were randomly grouped into 3 groups. One was considered as control and no medication was advised. The second group was advised 1000-1500 mg of calcium carbonate daily. The third group was given the same dose of calcium, but also received additionally another 2 mg of estradiol daily. Whole Body Retention (WBR) studies of Tc-99m MDP were carried out before starting treatment and at 6 monthly intervals for a period of 5 years. Serum calcium and alkaline phosphatase were estimated on fasting samples at the start of the study and at every 6 monthly intervals. WBR studies were done using a shadow shield whole body counter attached with a 5 inch diameter sodium iodide crystal detector and a 5 mm wide slit collimator. The WBR of Tc-99m MDP at 24 hours was found to be 27.55 ± 6.76% in women in the peri-menopausal age range of 25-45 years. It was also observed that at the time of menopause 13.3% of the women had WBR values above 2 SD of the normal values. This suggests that calcium loss from the skeleton is present only in a small number of women at menopause. However in women who were not supplemented with calcium or subjected to hormonal and calcium treatment, the number of women who showed loss of bone calcium increased within a period of 1-2 years after menopause. This simple method of WBR

  13. 12 CFR 5.4 - Filing required.

    Science.gov (United States)

    2010-01-01

    ... CORPORATE ACTIVITIES Rules of General Applicability § 5.4 Filing required. (a) Filing. A depository institution shall file an application or notice with the OCC to engage in corporate activities and... advise an applicant through a pre-filing communication to send the filing or submission directly to the...

  14. Huygens file service and storage architecture

    NARCIS (Netherlands)

    Bosch, H.G.P.; Mullender, Sape J.; Stabell-Kulo, Tage; Stabell-Kulo, Tage

    1993-01-01

    The Huygens file server is a high-performance file server which is able to deliver multi-media data in a timely manner while also providing clients with ordinary “Unix” like file I/O. The file server integrates client machines, file servers and tertiary storage servers in the same storage

  15. Huygens File Service and Storage Architecture

    NARCIS (Netherlands)

    Bosch, H.G.P.; Mullender, Sape J.; Stabell-Kulo, Tage; Stabell-Kulo, Tage

    1993-01-01

    The Huygens file server is a high-performance file server which is able to deliver multi-media data in a timely manner while also providing clients with ordinary “Unix” like file I/O. The file server integrates client machines, file servers and tertiary storage servers in the same storage

  16. APLIKASI ENKRIPSI DAN DEKRIPSI FILE DENGAN MENGGUNAKAN AES (ADVANCED ENCRYPTION STANDARD ALGORITMA RIJNDAEL PADA SISTEM OPERASI ANDROID

    Directory of Open Access Journals (Sweden)

    Langit Da Silva

    2015-04-01

    Full Text Available Rijndael algorithm is an algorithm that won the contest organized by NIST to replace DES algorithm known weaknesses . After winning the contest Rijndael algorithm , Rijndael lagoitma then serve as the AES ( Advanced Encryption Standard . This algorithm has been widely used in the encryption problem both for text , files , and databases . While Android is an open source operating system developed by Google . Currently Android operating system has become the operating system most widely used on smartphoanes . Smartphones now prevalent and had also been owned by many people because of its reliability. In this final project has been able to be made to solve the problem of software security file on the device that uses the Android operating system using AES ( Advanced Encryption Standard Rijndael algorithm . The method used in the design and manufacture of this software is the method GRAPPLE ( Guideliness for Rapid Application Engineering . The programming language used is Java . In the application can generate an encrypted file that can not be opened . To open the file , then the application can perform the decryption process . The parameters used in the analysis of this algorithm when used for encryption and decryption .

  17. Design Studies and Optimization of High-Field Nb$_3$Sn Dipole Magnets for a Future Very High Energy PP Collider

    Energy Technology Data Exchange (ETDEWEB)

    Kashikhin, V. V. [Fermilab; Novitski, I. [Fermilab; Zlobin, A. V. [Fermilab

    2017-05-01

    High filed accelerator magnets with operating fields of 15-16 T based on the $Nb_3Sn$ superconductor are being considered for the LHC energy upgrade or a future Very High Energy pp Collider. Magnet design studies are being conducted in the U.S., Europe and Asia to explore the limits of the $Nb_3Sn$ accelerator magnet technology while optimizing the magnet design and performance parame-ters, and reducing magnet cost. The first results of these studies performed at Fermilab in the framework of the US-MDP are reported in this paper.

  18. Apically extruded dentin debris by reciprocating single-file and multi-file rotary system.

    Science.gov (United States)

    De-Deus, Gustavo; Neves, Aline; Silva, Emmanuel João; Mendonça, Thais Accorsi; Lourenço, Caroline; Calixto, Camila; Lima, Edson Jorge Moreira

    2015-03-01

    This study aims to evaluate the apical extrusion of debris by the two reciprocating single-file systems: WaveOne and Reciproc. Conventional multi-file rotary system was used as a reference for comparison. The hypotheses tested were (i) the reciprocating single-file systems extrude more than conventional multi-file rotary system and (ii) the reciprocating single-file systems extrude similar amounts of dentin debris. After solid selection criteria, 80 mesial roots of lower molars were included in the present study. The use of four different instrumentation techniques resulted in four groups (n = 20): G1 (hand-file technique), G2 (ProTaper), G3 (WaveOne), and G4 (Reciproc). The apparatus used to evaluate the collection of apically extruded debris was typical double-chamber collector. Statistical analysis was performed for multiple comparisons. No significant difference was found in the amount of the debris extruded between the two reciprocating systems. In contrast, conventional multi-file rotary system group extruded significantly more debris than both reciprocating groups. Hand instrumentation group extruded significantly more debris than all other groups. The present results yielded favorable input for both reciprocation single-file systems, inasmuch as they showed an improved control of apically extruded debris. Apical extrusion of debris has been studied extensively because of its clinical relevance, particularly since it may cause flare-ups, originated by the introduction of bacteria, pulpal tissue, and irrigating solutions into the periapical tissues.

  19. 75 FR 52533 - Agency Information Collection Activities: Proposed Collection: Comment Request

    Science.gov (United States)

    2010-08-26

    ... Minimum Database Project Sickle Cell Trait/Carrier (MDP SCT) Questionnaire, and (3) the MDP Hemoglobinopathies Emerging Populations Questionnaire. Respondents: The MDP SCD and the MDP SCT Questionnaires will... participate in either the SCD questionnaire or the SCT questionnaire depending on their disease or carrier...

  20. Building a parallel file system simulator

    International Nuclear Information System (INIS)

    Molina-Estolano, E; Maltzahn, C; Brandt, S A; Bent, J

    2009-01-01

    Parallel file systems are gaining in popularity in high-end computing centers as well as commercial data centers. High-end computing systems are expected to scale exponentially and to pose new challenges to their storage scalability in terms of cost and power. To address these challenges scientists and file system designers will need a thorough understanding of the design space of parallel file systems. Yet there exist few systematic studies of parallel file system behavior at petabyte- and exabyte scale. An important reason is the significant cost of getting access to large-scale hardware to test parallel file systems. To contribute to this understanding we are building a parallel file system simulator that can simulate parallel file systems at very large scale. Our goal is to simulate petabyte-scale parallel file systems on a small cluster or even a single machine in reasonable time and fidelity. With this simulator, file system experts will be able to tune existing file systems for specific workloads, scientists and file system deployment engineers will be able to better communicate workload requirements, file system designers and researchers will be able to try out design alternatives and innovations at scale, and instructors will be able to study very large-scale parallel file system behavior in the class room. In this paper we describe our approach and provide preliminary results that are encouraging both in terms of fidelity and simulation scalability.

  1. 76 FR 52323 - Combined Notice of Filings; Filings Instituting Proceedings

    Science.gov (United States)

    2011-08-22

    .... Applicants: Young Gas Storage Company, Ltd. Description: Young Gas Storage Company, Ltd. submits tariff..., but intervention is necessary to become a party to the proceeding. The filings are accessible in the.... More detailed information relating to filing requirements, interventions, protests, and service can be...

  2. Flexible, Secure, and Reliable Data Sharing Service Based on Collaboration in Multicloud Environment

    Directory of Open Access Journals (Sweden)

    Qiang Wei

    2018-01-01

    Full Text Available Due to the abundant storage resources and high reliability data service of cloud computing, more individuals and enterprises are motivated to outsource their data to public cloud platform and enable legal data users to search and download what they need in the outsourced dataset. However, in “Paid Data Sharing” model, some valuable data should be encrypted before outsourcing for protecting owner’s economic benefits, which is an obstacle for flexible application. Specifically, if the owner does not know who (user will download which data files in advance and even does not know the attributes of user, he/she has to either remain online all the time or import a trusted third party (TTP to distribute the file decryption key to data user. Obviously, making the owner always remain online is too inflexible, and wholly depending on the security of TTP is a potential risk. In this paper, we propose a flexible, secure, and reliable data sharing scheme based on collaboration in multicloud environment. For securely and instantly providing data sharing service even if the owner is offline and without TTP, we distribute all encrypted split data/key blocks together to multiple cloud service providers (CSPs, respectively. An elaborate cryptographic protocol we designed helps the owner verify the correctness of data exchange bills, which is directly related to the owner’s economic benefits. Besides, in order to support reliable data service, the erasure-correcting code technic is exploited for tolerating multiple failures among CSPs, and we offer a secure keyword search mechanism that makes the system more close to reality. Extensive security analyses and experiments on real-world data show that our scheme is secure and efficient.

  3. Bring Your Own Device - Providing Reliable Model of Data Access

    Directory of Open Access Journals (Sweden)

    Stąpór Paweł

    2016-10-01

    Full Text Available The article presents a model of Bring Your Own Device (BYOD as a model network, which provides the user reliable access to network resources. BYOD is a model dynamically developing, which can be applied in many areas. Research network has been launched in order to carry out the test, in which as a service of BYOD model Work Folders service was used. This service allows the user to synchronize files between the device and the server. An access to the network is completed through the wireless communication by the 802.11n standard. Obtained results are shown and analyzed in this article.

  4. First use of LHC Run 3 Conditions Database infrastructure for auxiliary data files in ATLAS

    CERN Document Server

    AUTHOR|(INSPIRE)INSPIRE-00081940; The ATLAS collaboration; Barberis, Dario; Gallas, Elizabeth; Rybkin, Grigori; Rinaldi, Lorenzo; Aperio Bella, Ludovica; Buttinger, William

    2017-01-01

    Processing of the large amount of data produced by the ATLAS experiment requires fast and reliable access to what we call Auxiliary Data Files (ADF). These files, produced by Combined Performance, Trigger and Physics groups, contain conditions, calibrations, and other derived data used by the ATLAS software. In ATLAS this data has, thus far for historical reasons, been collected and accessed outside the ATLAS Conditions Database infrastructure and related software. For this reason, along with the fact that ADF are effectively read by the software as binary objects, this class of data appears ideal for testing the proposed Run 3 conditions data infrastructure now in development. This paper describes this implementation as well as the lessons learned in exploring and refining the new infrastructure with the potential for deployment during Run 2.

  5. First Use of LHC Run 3 Conditions Database Infrastructure for Auxiliary Data Files in ATLAS

    CERN Document Server

    Aperio Bella, Ludovica; The ATLAS collaboration

    2016-01-01

    Processing of the large amount of data produced by the ATLAS experiment requires fast and reliable access to what we call Auxiliary Data Files (ADF). These files, produced by Combined Performance, Trigger and Physics groups, contain conditions, calibrations, and other derived data used by the ATLAS software. In ATLAS this data has, thus far for historical reasons, been collected and accessed outside the ATLAS Conditions Database infrastructure and related software. For this reason, along with the fact that ADF data is effectively read by the software as binary objects, makes this class of data ideal for testing the proposed Run 3 Conditions data infrastructure now in development. This paper will describe this implementation as well as describe the lessons learned in exploring and refining the new infrastructure with the potential for deployment during Run 2.

  6. Potential pitfalls of steatopygia on bone imaging using Tc99m MDP and role of SPECT

    International Nuclear Information System (INIS)

    Elgazzar, H; Elsaid, M; Omar, A; Al-Maskery, IB

    2004-01-01

    Body habbitus influence the quality of bone scintigraphy. Steatopygia (steato: fat, pygia: buttocks) may affect the quality of bone scan since it may lead to diagnostic pitfalls. Objective: The objective of this prospective study is to evaluate the effects of steatopygia on the appearance of the lumbar spine on bone scan and the role of SPECT in overcoming fat attenuation artifact if present. Method: Bone scintigraphy, including whole body bone scan, spot views and SPECT of the lumber spine, using a dual head gamma camera, were performed on thirty adult obese patients (13 males, 17 females) with an average weight of 90 kg. referred to the department for routine bone scan. Each patient was injected intravenously with 0.25 mCi/kg (9.25 Mbq of Tc-99m MDP, and their weight and height of each patient were recorded. Whole body scan was performed using 256 X 1024 matrix size and 8 min/meter speed. SPECT was performed using 128 X 128 matrix size, 20 second-32 projections and elliptical orbit around the lumbar spine. Spot views were acquired using 256X256 matrix size for 1000 Kcounts. Results: Twenty patients (67%) (6 males, 14 females) showed steatopygia with attenuation at the lower lumber vertebrae. Diminished uptake in the lower lumbar spine and edge effect artifacts were noted on planar images mimicking abnormalities. SPECT, especially in the sagittal axis, resolved these artifacts. Conclusion: Steatopygia should be considered in the interpretation of bone scans of obese patients to avoid diagnostic pitfalls. Adding SPECT of the lumber spine to the planar imaging improves the diagnostic accuracy in obese patients by overcoming the steatopygia effect seen on whole body and spot planar images. (authors)

  7. Evaluated neutronic file for indium

    International Nuclear Information System (INIS)

    Smith, A.B.; Chiba, S.; Smith, D.L.; Meadows, J.W.; Guenther, P.T.; Lawson, R.D.; Howerton, R.J.

    1990-01-01

    A comprehensive evaluated neutronic data file for elemental indium is documented. This file, extending from 10 -5 eV to 20 MeV, is presented in the ENDF/B-VI format, and contains all neutron-induced processes necessary for the vast majority of neutronic applications. In addition, an evaluation of the 115 In(n,n') 116m In dosimetry reaction is presented as a separate file. Attention is given in quantitative values, with corresponding uncertainty information. These files have been submitted for consideration as a part of the ENDF/B-VI national evaluated-file system. 144 refs., 10 figs., 4 tabs

  8. FHEO Filed Cases

    Data.gov (United States)

    Department of Housing and Urban Development — The dataset is a list of all the Title VIII fair housing cases filed by FHEO from 1/1/2007 - 12/31/2012 including the case number, case name, filing date, state and...

  9. Radionuclide Tc-99m MDP Imaging for diagnosis of bone tumour at Korle-Bu Teaching Hospital (Ghana): an illustrative review

    International Nuclear Information System (INIS)

    Hasford, F.; Sosu, E.K.; Nani, K.; Sackey, T.A.; Boadu, M.; Wilson, I.K.; Addison, E.C.K.; Amuasi, J.H.

    2010-01-01

    Radioisotopes are used in diagnosing primary and metastatic bone tumours because of the high sensitivity. Diagnosing bone tumours using technetium methylene diphosphonate (Tc-99m MDP) on 9 randomly selected whole-body bone scans have been demonstrated by clinical studies of patients for illustrative review. Upon satisfactory testing of the e.cam (R) Single Photon Emission Computed Tomography at the Nuclear Medicine Department (Korle-Bu Teaching Hospital), scans of patients provided essential physiologic information about the sites of bone lesions and prognosis as shown by sequential changes in tracer uptake. The bone scintigrams were classified either as normal or pathologic. Of the 197 patients (91 males and 106 females) who underwent radioactive whole-body scans in the year 2006, the peak age at bone tumour detection was between 51 and 60 years. From qualitative analyses of the reported cases, 144 patients were diagnosed with bone tumours, but ∼ 17 % were found to be primary, while ∼ 83 % were metastatic in nature. The observation confirmed other published data that bone tumours with origin in the cells of bone are not prevalent compared to tumours that metastasize from other parts of the body, such as breast, cervix and prostate. Breast, prostate and cervical cancers contributed respectively to 34 %, 19 % and 18 % of the bone tumour cases, but only 3 % were diagnosed with osteoporosis (a relatively rare type of bone disease). (au)

  10. Reliability engineering

    International Nuclear Information System (INIS)

    Lee, Chi Woo; Kim, Sun Jin; Lee, Seung Woo; Jeong, Sang Yeong

    1993-08-01

    This book start what is reliability? such as origin of reliability problems, definition of reliability and reliability and use of reliability. It also deals with probability and calculation of reliability, reliability function and failure rate, probability distribution of reliability, assumption of MTBF, process of probability distribution, down time, maintainability and availability, break down maintenance and preventive maintenance design of reliability, design of reliability for prediction and statistics, reliability test, reliability data and design and management of reliability.

  11. 76 FR 62092 - Filing Procedures

    Science.gov (United States)

    2011-10-06

    ... INTERNATIONAL TRADE COMMISSION Filing Procedures AGENCY: International Trade Commission. ACTION: Notice of issuance of Handbook on Filing Procedures. SUMMARY: The United States International Trade Commission (``Commission'') is issuing a Handbook on Filing Procedures to replace its Handbook on Electronic...

  12. 12 CFR 1780.9 - Filing of papers.

    Science.gov (United States)

    2010-01-01

    ... 12 Banks and Banking 7 2010-01-01 2010-01-01 false Filing of papers. 1780.9 Section 1780.9 Banks... papers. (a) Filing. Any papers required to be filed shall be addressed to the presiding officer and filed... Director or the presiding officer. All papers filed by electronic media shall also concurrently be filed in...

  13. The Jade File System. Ph.D. Thesis

    Science.gov (United States)

    Rao, Herman Chung-Hwa

    1991-01-01

    File systems have long been the most important and most widely used form of shared permanent storage. File systems in traditional time-sharing systems, such as Unix, support a coherent sharing model for multiple users. Distributed file systems implement this sharing model in local area networks. However, most distributed file systems fail to scale from local area networks to an internet. Four characteristics of scalability were recognized: size, wide area, autonomy, and heterogeneity. Owing to size and wide area, techniques such as broadcasting, central control, and central resources, which are widely adopted by local area network file systems, are not adequate for an internet file system. An internet file system must also support the notion of autonomy because an internet is made up by a collection of independent organizations. Finally, heterogeneity is the nature of an internet file system, not only because of its size, but also because of the autonomy of the organizations in an internet. The Jade File System, which provides a uniform way to name and access files in the internet environment, is presented. Jade is a logical system that integrates a heterogeneous collection of existing file systems, where heterogeneous means that the underlying file systems support different file access protocols. Because of autonomy, Jade is designed under the restriction that the underlying file systems may not be modified. In order to avoid the complexity of maintaining an internet-wide, global name space, Jade permits each user to define a private name space. In Jade's design, we pay careful attention to avoiding unnecessary network messages between clients and file servers in order to achieve acceptable performance. Jade's name space supports two novel features: (1) it allows multiple file systems to be mounted under one direction; and (2) it permits one logical name space to mount other logical name spaces. A prototype of Jade was implemented to examine and validate its

  14. The Galley Parallel File System

    Science.gov (United States)

    Nieuwejaar, Nils; Kotz, David

    1996-01-01

    Most current multiprocessor file systems are designed to use multiple disks in parallel, using the high aggregate bandwidth to meet the growing I/0 requirements of parallel scientific applications. Many multiprocessor file systems provide applications with a conventional Unix-like interface, allowing the application to access multiple disks transparently. This interface conceals the parallelism within the file system, increasing the ease of programmability, but making it difficult or impossible for sophisticated programmers and libraries to use knowledge about their I/O needs to exploit that parallelism. In addition to providing an insufficient interface, most current multiprocessor file systems are optimized for a different workload than they are being asked to support. We introduce Galley, a new parallel file system that is intended to efficiently support realistic scientific multiprocessor workloads. We discuss Galley's file structure and application interface, as well as the performance advantages offered by that interface.

  15. SU-E-T-184: Clinical VMAT QA Practice Using LINAC Delivery Log Files

    International Nuclear Information System (INIS)

    Johnston, H; Jacobson, T; Gu, X; Jiang, S; Stojadinovic, S

    2015-01-01

    Purpose: To evaluate the accuracy of volumetric modulated arc therapy (VMAT) treatment delivery dose clouds by comparing linac log data to doses measured using an ionization chamber and film. Methods: A commercial IMRT quality assurance (QA) process utilizing a DICOM-RT framework was tested for clinical practice using 30 prostate and 30 head and neck VMAT plans. Delivered 3D VMAT dose distributions were independently checked using a PinPoint ionization chamber and radiographic film in a solid water phantom. DICOM RT coordinates were used to extract the corresponding point and planar doses from 3D log file dose distributions. Point doses were evaluated by computing the percent error between log file and chamber measured values. A planar dose evaluation was performed for each plan using a 2D gamma analysis with 3% global dose difference and 3 mm isodose point distance criteria. The same analysis was performed to compare treatment planning system (TPS) doses to measured values to establish a baseline assessment of agreement. Results: The mean percent error between log file and ionization chamber dose was 1.0%±2.1% for prostate VMAT plans and −0.2%±1.4% for head and neck plans. The corresponding TPS calculated and measured ionization chamber values agree within 1.7%±1.6%. The average 2D gamma passing rates for the log file comparison to film are 98.8%±1.0% and 96.2%±4.2% for the prostate and head and neck plans, respectively. The corresponding passing rates for the TPS comparison to film are 99.4%±0.5% and 93.9%±5.1%. Overall, the point dose and film data indicate that log file determined doses are in excellent agreement with measured values. Conclusion: Clinical VMAT QA practice using LINAC treatment log files is a fast and reliable method for patient-specific plan evaluation

  16. The Reliability and Predictive Validity of the Stalking Risk Profile.

    Science.gov (United States)

    McEwan, Troy E; Shea, Daniel E; Daffern, Michael; MacKenzie, Rachel D; Ogloff, James R P; Mullen, Paul E

    2018-03-01

    This study assessed the reliability and validity of the Stalking Risk Profile (SRP), a structured measure for assessing stalking risks. The SRP was administered at the point of assessment or retrospectively from file review for 241 adult stalkers (91% male) referred to a community-based forensic mental health service. Interrater reliability was high for stalker type, and moderate-to-substantial for risk judgments and domain scores. Evidence for predictive validity and discrimination between stalking recidivists and nonrecidivists for risk judgments depended on follow-up duration. Discrimination was moderate (area under the curve = 0.66-0.68) and positive and negative predictive values good over the full follow-up period ( Mdn = 170.43 weeks). At 6 months, discrimination was better than chance only for judgments related to stalking of new victims (area under the curve = 0.75); however, high-risk stalkers still reoffended against their original victim(s) 2 to 4 times as often as low-risk stalkers. Implications for the clinical utility and refinement of the SRP are discussed.

  17. Creating animated GIF files for electronic presentations using Photoshop.

    Science.gov (United States)

    Yam, Chun-Shan; Kruskal, Jonathan; Larson, Michael

    2007-05-01

    Our objective is to present a simple method for converting movie clips to animated GIFs (graphics interchange format) using Photoshop. Although animated GIF is a more reliable format than movie clips (e.g., AVI and QuickTime) for presenting dynamic data sets in PowerPoint presentations, this output format is not available on most radiology workstations. Therefore, many academic radiologists still experience the problem of incompatible codecs and missing file links when trying to show movie clips in their PowerPoint presentations. One way to resolve this issue is to convert the movie clips to animated GIFs. In this article, we provide a simple method for this conversion using Photoshop--a common software application used by radiologists.

  18. 78 FR 21930 - Aquenergy Systems, Inc.; Notice of Intent To File License Application, Filing of Pre-Application...

    Science.gov (United States)

    2013-04-12

    ... Systems, Inc.; Notice of Intent To File License Application, Filing of Pre-Application Document, and Approving Use of the Traditional Licensing Process a. Type of Filing: Notice of Intent to File License...: November 11, 2012. d. Submitted by: Aquenergy Systems, Inc., a fully owned subsidiaries of Enel Green Power...

  19. Associations among q-space MRI, diffusion-weighted MRI and histopathological parameters in meningiomas

    Energy Technology Data Exchange (ETDEWEB)

    Fatima, Zareen; Motosugi, Utaroh; Ishigame, Keiichi; Araki, Tsutomu [University of Yamanashi, Department of Radiology, Chuo-shi, Yamanashi (Japan); Waqar, Ahmed Bilal [University of Yamanashi, Department of Molecular Pathology, Interdisciplinary Graduate School of Medicine and Engineering, Chuo-shi, Yamanashi (Japan); Hori, Masaaki [Juntendo University, Department of Radiology, School of Medicine, Tokyo (Japan); Oishi, Naoki; Katoh, Ryohei [University of Yamanashi, Department of Pathology, Chuo-shi, Yamanashi (Japan); Onodera, Toshiyuki; Yagi, Kazuo [Tokyo Metropolitan University, Department of Radiological Sciences, Graduate School of Human Health Sciences, Tokyo (Japan)

    2013-08-15

    The purposes of this MR-based study were to calculate q-space imaging (QSI)-derived mean displacement (MDP) in meningiomas, to evaluate the correlation of MDP values with apparent diffusion coefficient (ADC) and to investigate the relationships among these diffusion parameters, tumour cell count (TCC) and MIB-1 labelling index (LI). MRI, including QSI and conventional diffusion-weighted imaging (DWI), was performed in 44 meningioma patients (52 lesions). ADC and MDP maps were acquired from post-processing of the data. Quantitative analyses of these maps were performed by applying regions of interest. Pearson correlation coefficients were calculated for ADC and MDP in all lesions and for ADC and TCC, MDP and TCC, ADC and MIB-1 LI, and MDP and MIB-1 LI in 17 patients who underwent subsequent surgery. ADC and MDP values were found to have a strong correlation: r = 0.78 (P = <0.0001). Both ADC and MDP values had a significant negative association with TCC: r = -0.53 (p = 0.02) and -0.48 (P = 0.04), respectively. MIB-1 LI was not, however, found to have a significant association with these diffusion parameters. In meningiomas, both ADC and MDP may be representative of cell density. (orig.)

  20. Associations among q-space MRI, diffusion-weighted MRI and histopathological parameters in meningiomas

    International Nuclear Information System (INIS)

    Fatima, Zareen; Motosugi, Utaroh; Ishigame, Keiichi; Araki, Tsutomu; Waqar, Ahmed Bilal; Hori, Masaaki; Oishi, Naoki; Katoh, Ryohei; Onodera, Toshiyuki; Yagi, Kazuo

    2013-01-01

    The purposes of this MR-based study were to calculate q-space imaging (QSI)-derived mean displacement (MDP) in meningiomas, to evaluate the correlation of MDP values with apparent diffusion coefficient (ADC) and to investigate the relationships among these diffusion parameters, tumour cell count (TCC) and MIB-1 labelling index (LI). MRI, including QSI and conventional diffusion-weighted imaging (DWI), was performed in 44 meningioma patients (52 lesions). ADC and MDP maps were acquired from post-processing of the data. Quantitative analyses of these maps were performed by applying regions of interest. Pearson correlation coefficients were calculated for ADC and MDP in all lesions and for ADC and TCC, MDP and TCC, ADC and MIB-1 LI, and MDP and MIB-1 LI in 17 patients who underwent subsequent surgery. ADC and MDP values were found to have a strong correlation: r = 0.78 (P = <0.0001). Both ADC and MDP values had a significant negative association with TCC: r = -0.53 (p = 0.02) and -0.48 (P = 0.04), respectively. MIB-1 LI was not, however, found to have a significant association with these diffusion parameters. In meningiomas, both ADC and MDP may be representative of cell density. (orig.)

  1. 12 CFR 16.33 - Filing fees.

    Science.gov (United States)

    2010-01-01

    ... Banking COMPTROLLER OF THE CURRENCY, DEPARTMENT OF THE TREASURY SECURITIES OFFERING DISCLOSURE RULES § 16.33 Filing fees. (a) Filing fees must accompany certain filings made under the provisions of this part... Comptroller of the Currency Fees published pursuant to § 8.8 of this chapter. (b) Filing fees must be paid by...

  2. 75 FR 4689 - Electronic Tariff Filings

    Science.gov (United States)

    2010-01-29

    ... elements ``are required to properly identify the nature of the tariff filing, organize the tariff database... (or other pleading) and the Type of Filing code chosen will be resolved in favor of the Type of Filing...'s wish expressed in its transmittal letter or in other pleadings, the Commission may not review a...

  3. Experimental study on the usefulness of magnetotherapy in bone fractures (tibial osteotomy in the rat). Accumulation of 99 mTc MDP - tests of tensile strength - determination of alkaline phosphatase

    International Nuclear Information System (INIS)

    Sailer, R.

    1985-01-01

    Non-directional magnetic field therapy using a flux density of 60 G and a frequency of 25 Hz was carried out over 12 hours daily in rats in order to ascertain its influence on the healing process following osteotomy of the tibia with internal splint fixation of the fractured bone being carried out as an additional measure. The results thus achieved were compared to those seen in control animals, were no magnetotherapy was carried out, on the basis of scintiscan studies using 99 mTc MDP (degree of density in the callus formed around the fracture zone), the plasma levels of alkaline phosphatase and tests of tensile strength. The follow-up observations of the healing process were additionally based on radiological and histological evaluations of the animals. Beneficial effects of magnetotherapy on the healing process could not be confirmed with any statistical significance. (TRV) [de

  4. 78 FR 75554 - Combined Notice of Filings

    Science.gov (United States)

    2013-12-12

    ...-000. Applicants: Young Gas Storage Company, Ltd. Description: Young Fuel Reimbursement Filing to be.... Protests may be considered, but intervention is necessary to become a party to the proceeding. eFiling is... qualifying facilities filings can be found at: http://www.ferc.gov/docs-filing/efiling/filing-req.pdf . For...

  5. Small file aggregation in a parallel computing system

    Science.gov (United States)

    Faibish, Sorin; Bent, John M.; Tzelnic, Percy; Grider, Gary; Zhang, Jingwang

    2014-09-02

    Techniques are provided for small file aggregation in a parallel computing system. An exemplary method for storing a plurality of files generated by a plurality of processes in a parallel computing system comprises aggregating the plurality of files into a single aggregated file; and generating metadata for the single aggregated file. The metadata comprises an offset and a length of each of the plurality of files in the single aggregated file. The metadata can be used to unpack one or more of the files from the single aggregated file.

  6. 5 CFR 1203.13 - Filing pleadings.

    Science.gov (United States)

    2010-01-01

    ... delivery, by facsimile, or by e-filing in accordance with § 1201.14 of this chapter. If the document was... submitted by e-filing, it is considered to have been filed on the date of electronic submission. (e... 5 Administrative Personnel 3 2010-01-01 2010-01-01 false Filing pleadings. 1203.13 Section 1203.13...

  7. PFS: a distributed and customizable file system

    NARCIS (Netherlands)

    Bosch, H.G.P.; Mullender, Sape J.

    1996-01-01

    In this paper we present our ongoing work on the Pegasus File System (PFS), a distributed and customizable file system that can be used for off-line file system experiments and on-line file system storage. PFS is best described as an object-oriented component library from which either a true file

  8. 76 FR 61351 - Combined Notice of Filings #1

    Science.gov (United States)

    2011-10-04

    ... MBR Baseline Tariff Filing to be effective 9/22/2011. Filed Date: 09/22/2011. Accession Number... submits tariff filing per 35.1: ECNY MBR Re-File to be effective 9/22/2011. Filed Date: 09/22/2011... Industrial Energy Buyers, LLC submits tariff filing per 35.1: NYIEB MBR Re-File to be effective 9/22/2011...

  9. 10 CFR 110.89 - Filing and service.

    Science.gov (United States)

    2010-01-01

    ...: Rulemakings and Adjudications Staff or via the E-Filing system, following the procedure set forth in 10 CFR 2.302. Filing by mail is complete upon deposit in the mail. Filing via the E-Filing system is completed... residence with some occupant of suitable age and discretion; (2) Following the requirements for E-Filing in...

  10. 49 CFR 1104.6 - Timely filing required.

    Science.gov (United States)

    2010-10-01

    ... offers next day delivery to Washington, DC. If the e-filing option is chosen (for those pleadings and documents that are appropriate for e-filing, as determined by reference to the information on the Board's Web site), then the e-filed pleading or document is timely filed if the e-filing process is completed...

  11. DICOM supported sofware configuration by XML files

    International Nuclear Information System (INIS)

    LucenaG, Bioing Fabian M; Valdez D, Andres E; Gomez, Maria E; Nasisi, Oscar H

    2007-01-01

    A method for the configuration of informatics systems that provide support to DICOM standards using XML files is proposed. The difference with other proposals is base on that this system does not code the information of a DICOM objects file, but codes the standard itself in an XML file. The development itself is the format for the XML files mentioned, in order that they can support what DICOM normalizes for multiple languages. In this way, the same configuration file (or files) can be use in different systems. Jointly the XML configuration file generated, we wrote also a set of CSS and XSL files. So the same file can be visualized in a standard browser, as a query system of DICOM standard, emerging use, that did not was a main objective but brings a great utility and versatility. We exposed also some uses examples of the configuration file mainly in relation with the load of DICOM information objects. Finally, at the conclusions we show the utility that the system has already provided when the edition of DICOM standard changes from 2006 to 2007

  12. On Optimal Policies for Network-Coded Cooperation

    DEFF Research Database (Denmark)

    Khamfroush, Hana; Roetter, Daniel Enrique Lucani; Pahlevani, Peyman

    2015-01-01

    Network-coded cooperative communication (NC-CC) has been proposed and evaluated as a powerful technology that can provide a better quality of service in the next-generation wireless systems, e.g., D2D communications. Previous contributions have focused on performance evaluation of NC-CC scenarios...... rather than searching for optimal policies that can minimize the total cost of reliable packet transmission. We break from this trend by initially analyzing the optimal design of NC-CC for a wireless network with one source, two receivers, and half-duplex erasure channels. The problem is modeled...... as a special case of Markov decision process (MDP), which is called stochastic shortest path (SSP), and is solved for any field size, arbitrary number of packets, and arbitrary erasure probabilities of the channels. The proposed MDP solution results in an optimal transmission policy per time slot, and we use...

  13. 12 CFR 908.25 - Filing of papers.

    Science.gov (United States)

    2010-01-01

    ... 12 Banks and Banking 7 2010-01-01 2010-01-01 false Filing of papers. 908.25 Section 908.25 Banks... RULES OF PRACTICE AND PROCEDURE IN HEARINGS ON THE RECORD General Rules § 908.25 Filing of papers. (a) Filing. Any papers required to be filed shall be addressed to the presiding officer and filed with the...

  14. PFS: a distributed and customizable file system

    OpenAIRE

    Bosch, H.G.P.; Mullender, Sape J.

    1996-01-01

    In this paper we present our ongoing work on the Pegasus File System (PFS), a distributed and customizable file system that can be used for off-line file system experiments and on-line file system storage. PFS is best described as an object-oriented component library from which either a true file system or a file-system simulator can be constructed. Each of the components in the library is easily replaced by another implementation to accommodate a wide range of applications.

  15. Systems reliability/structural reliability

    International Nuclear Information System (INIS)

    Green, A.E.

    1980-01-01

    The question of reliability technology using quantified techniques is considered for systems and structures. Systems reliability analysis has progressed to a viable and proven methodology whereas this has yet to be fully achieved for large scale structures. Structural loading variants over the half-time of the plant are considered to be more difficult to analyse than for systems, even though a relatively crude model may be a necessary starting point. Various reliability characteristics and environmental conditions are considered which enter this problem. The rare event situation is briefly mentioned together with aspects of proof testing and normal and upset loading conditions. (orig.)

  16. Detecting Malicious Code by Binary File Checking

    Directory of Open Access Journals (Sweden)

    Marius POPA

    2014-01-01

    Full Text Available The object, library and executable code is stored in binary files. Functionality of a binary file is altered when its content or program source code is changed, causing undesired effects. A direct content change is possible when the intruder knows the structural information of the binary file. The paper describes the structural properties of the binary object files, how the content can be controlled by a possible intruder and what the ways to identify malicious code in such kind of files. Because the object files are inputs in linking processes, early detection of the malicious content is crucial to avoid infection of the binary executable files.

  17. Formalizing a hierarchical file system

    NARCIS (Netherlands)

    Hesselink, Wim H.; Lali, Muhammad Ikram

    An abstract file system is defined here as a partial function from (absolute) paths to data. Such a file system determines the set of valid paths. It allows the file system to be read and written at a valid path, and it allows the system to be modified by the Unix operations for creation, removal,

  18. Reliability Engineering

    International Nuclear Information System (INIS)

    Lee, Sang Yong

    1992-07-01

    This book is about reliability engineering, which describes definition and importance of reliability, development of reliability engineering, failure rate and failure probability density function about types of it, CFR and index distribution, IFR and normal distribution and Weibull distribution, maintainability and movability, reliability test and reliability assumption in index distribution type, normal distribution type and Weibull distribution type, reliability sampling test, reliability of system, design of reliability and functionality failure analysis by FTA.

  19. Validação da proteína MDP2 de Mycobacterium tuberculosis H37Rv como uma proteína intrinsecamente desordenada e geração de uma cepa nocaute para o gene hns

    OpenAIRE

    Abbadi, Bruno Lopes

    2014-01-01

    A proteína micobacteriana ligadora de DNA 2 (MDP2) de Mycobacterium tuberculosis é uma proteína pequena e de caráter básico, conhecida por se ligar ao DNA de uma forma não es-pecífica e de ancorar o nucleóide à membrana plasmática promovendo o seu desempacota-mento. Motivados por uma predição de desordem intrínseca in silico prévia, nós usamos um conjunto de técnicas complementares para caracterizar esta proteína, tais como determina-ção da estabilidade ao calor e a desnaturantes químicos, ge...

  20. 77 FR 74839 - Combined Notice of Filings

    Science.gov (United States)

    2012-12-18

    ..., LP. Description: National Grid LNG, LP submits tariff filing per 154.203: Adoption of NAESB Version 2... with Order to Amend NAESB Version 2.0 Filing to be effective 12/1/2012. Filed Date: 12/11/12. Accession...: Refile to comply with Order on NAESB Version 2.0 Filing to be effective 12/1/2012. Filed Date: 12/11/12...

  1. Formalizing a Hierarchical File System

    NARCIS (Netherlands)

    Hesselink, Wim H.; Lali, M.I.

    2009-01-01

    In this note, we define an abstract file system as a partial function from (absolute) paths to data. Such a file system determines the set of valid paths. It allows the file system to be read and written at a valid path, and it allows the system to be modified by the Unix operations for removal

  2. 77 FR 35371 - Combined Notice of Filings #1

    Science.gov (United States)

    2012-06-13

    .... Applicants: Duke Energy Miami Fort, LLC. Description: MBR Filing to be effective 10/1/2012. Filed Date: 6/5...-000. Applicants: Duke Energy Piketon, LLC. Description: MBR Filing to be effective 10/1/2012. Filed...-1959-000. Applicants: Duke Energy Stuart, LLC. Description: MBR Filing to be effective 10/1/2012. Filed...

  3. Reliability

    OpenAIRE

    Condon, David; Revelle, William

    2017-01-01

    Separating the signal in a test from the irrelevant noise is a challenge for all measurement. Low test reliability limits test validity, attenuates important relationships, and can lead to regression artifacts. Multiple approaches to the assessment and improvement of reliability are discussed. The advantages and disadvantages of several different approaches to reliability are considered. Practical advice on how to assess reliability using open source software is provided.

  4. An Evaluation of American English File Series

    Directory of Open Access Journals (Sweden)

    Behnam Ghasemi

    2012-03-01

    Full Text Available Textbooks play a pivotal role in language learning classrooms. The problem is that among a wide range of textbooks in market which is appropriate for a specific classroom and a group of learners. In order to evaluate ELT textbooks theorists and writers have offered different kinds of evaluative frameworks based on a number of principles and criteria. This study evaluates a series of ELT textbook, namely, American English File by the use of Littlejohn’s (1998 evaluative framework to see what explicit features of the book are, what pedagogic values it has, whether it is in line with its claimed objectives, and what its merits and demerits are. Littlejohn believes that we should evaluate a textbook based on its own pedagogic values and we should see what is in it not what teacher and evaluators think must exist in it. Consequently his framework is claimed to be devoid of any impressionistic ideas and it is in-depth and objective rather than being subjective. Nine ELT experts and ten ELT teachers helped the researcher rate the evaluative checklists. The results of the study show that although a number of shortcomings and drawbacks were found in American English File, it stood up reasonably well to a detailed and in-depth analysis and that its pedagogic values and positive attributes far out-weighed its shortcomings. The internal consistency between ratings was computed via the statistical tool of Cronbach’s alpha that indicated a desirable inter-rater reliability.

  5. Virtual file system for PSDS

    Science.gov (United States)

    Runnels, Tyson D.

    1993-01-01

    This is a case study. It deals with the use of a 'virtual file system' (VFS) for Boeing's UNIX-based Product Standards Data System (PSDS). One of the objectives of PSDS is to store digital standards documents. The file-storage requirements are that the files must be rapidly accessible, stored for long periods of time - as though they were paper, protected from disaster, and accumulative to about 80 billion characters (80 gigabytes). This volume of data will be approached in the first two years of the project's operation. The approach chosen is to install a hierarchical file migration system using optical disk cartridges. Files are migrated from high-performance media to lower performance optical media based on a least-frequency-used algorithm. The optical media are less expensive per character stored and are removable. Vital statistics about the removable optical disk cartridges are maintained in a database. The assembly of hardware and software acts as a single virtual file system transparent to the PSDS user. The files are copied to 'backup-and-recover' media whose vital statistics are also stored in the database. Seventeen months into operation, PSDS is storing 49 gigabytes. A number of operational and performance problems were overcome. Costs are under control. New and/or alternative uses for the VFS are being considered.

  6. 76 FR 63291 - Combined Notice Of Filings #1

    Science.gov (United States)

    2011-10-12

    ... filing per 35: MBR Tariff to be effective 9/23/2011. Filed Date: 09/23/2011. Accession Number: 20110923.... submits tariff filing per 35: MBR Tariff to be effective 9/23/2011. Filed Date: 09/23/2011. Accession.... submits tariff filing per 35: MBR Tariff to be effective 9/23/2011. Filed Date: 09/23/2011. Accession...

  7. Titanium-II: an evaluated nuclear data file

    International Nuclear Information System (INIS)

    Philis, C.; Howerton, R.; Smith, A.B.

    1977-06-01

    A comprehensive evaluated nuclear data file for elemental titanium is outlined including definition of the data base, the evaluation procedures and judgments, and the final evaluated results. The file describes all significant neutron-induced reactions with elemental titanium and the associated photon-production processes to incident neutron energies of 20.0 MeV. In addition, isotopic-reaction files, consistent with the elemental file, are separately defined for those processes which are important to applied considerations of material-damage and neutron-dosimetry. The file is formulated in the ENDF format. This report formally documents the evaluation and, together with the numerical file, is submitted for consideration as a part of the ENDF/B-V evaluated file system. 20 figures, 9 tables

  8. Preservation of root canal anatomy using self-adjusting file instrumentation with glide path prepared by 20/0.02 hand files versus 20/0.04 rotary files

    Science.gov (United States)

    Jain, Niharika; Pawar, Ajinkya M.; Ukey, Piyush D.; Jain, Prashant K.; Thakur, Bhagyashree; Gupta, Abhishek

    2017-01-01

    Objectives: To compare the relative axis modification and canal concentricity after glide path preparation with 20/0.02 hand K-file (NITIFLEX®) and 20/0.04 rotary file (HyFlex™ CM) with subsequent instrumentation with 1.5 mm self-adjusting file (SAF). Materials and Methods: One hundred and twenty ISO 15, 0.02 taper, Endo Training Blocks (Dentsply Maillefer, Ballaigues, Switzerland) were acquired and randomly divided into following two groups (n = 60): group 1, establishing glide path till 20/0.02 hand K-file (NITIFLEX®) followed by instrumentation with 1.5 mm SAF; and Group 2, establishing glide path till 20/0.04 rotary file (HyFlex™ CM) followed by instrumentation with 1.5 mm SAF. Pre- and post-instrumentation digital images were processed with MATLAB R 2013 software to identify the central axis, and then superimposed using digital imaging software (Picasa 3.0 software, Google Inc., California, USA) taking five landmarks as reference points. Student's t-test for pairwise comparisons was applied with the level of significance set at 0.05. Results: Training blocks instrumented with 20/0.04 rotary file and SAF were associated less deviation in canal axis (at all the five marked points), representing better canal concentricity compared to those, in which glide path was established by 20/0.02 hand K-files followed by SAF instrumentation. Conclusion: Canal geometry is better maintained after SAF instrumentation with a prior glide path established with 20/0.04 rotary file. PMID:28855752

  9. 76 FR 28018 - Combined Notice of Filings #1

    Science.gov (United States)

    2011-05-13

    ... tariff filing per 35.13(a)(2)(iii: Information Policy Revisions to be effective 6/20/ 2011. Filed Date... Interconnection, L.L.C. Description: PJM Interconnection, L.L.C. submits tariff filing per 35.13(a)(2)(iii: Queue... New Mexico submits tariff filing per 35.13(a)(2)(iii: PNM LGIP Filing to be effective 7/5/2011. Filed...

  10. 75 FR 62381 - Combined Notice of Filings #2

    Science.gov (United States)

    2010-10-08

    ... filing per 35.12: MeadWestvaco Virginia MBR Filing to be effective 9/ 28/2010. Filed Date: 09/29/2010... submits tariff filing per 35.12: City Power MBR Tariff to be effective 9/30/2010. Filed Date: 09/29/2010... Baseline MBR Tariff to be effective 9[sol]29[sol]2010. Filed Date: 09/29/2010. Accession Number: 20100929...

  11. Evaluation of canal transportation after preparation with Reciproc single-file systems with or without glide path files.

    Science.gov (United States)

    Aydin, Ugur; Karataslioglu, Emrah

    2017-01-01

    Canal transportation is a common sequel caused by rotary instruments. The purpose of the present study is to evaluate the degree of transportation after the use of Reciproc single-file instruments with or without glide path files. Thirty resin blocks with L-shaped canals were divided into three groups ( n = 10). Group 1 - canals were prepared with Reciproc-25 file. Group 2 - glide path file-G1 was used before Reciproc. Group 3 - glide path files-G1 and G2 were used before Reciproc. Pre- and post-instrumentation images were superimposed under microscope, and resin removed from the inner and outer surfaces of the root canal was calculated throughout 10 points. Statistical analysis was performed with Kruskal-Wallis test and post hoc Dunn test. For coronal and middle one-thirds, there was no significant difference among groups ( P > 0.05). For apical section, transportation of Group 1 was significantly higher than other groups ( P files before Reciproc single-file system reduced the degree of apical canal transportation.

  12. 77 FR 13587 - Combined Notice of Filings

    Science.gov (United States)

    2012-03-07

    .... Applicants: Transcontinental Gas Pipe Line Company. Description: Annual Electric Power Tracker Filing... Company. Description: 2012 Annual Fuel and Electric Power Reimbursement to be effective 4/1/2012. Filed... submits tariff filing per 154.403: Storm Surcharge 2012 to be effective 4/1/2012. Filed Date: 3/1/12...

  13. 10 CFR 2.302 - Filing of documents.

    Science.gov (United States)

    2010-01-01

    ... this part shall be electronically transmitted through the E-Filing system, unless the Commission or... all methods of filing have been completed. (e) For filings by electronic transmission, the filer must... digital ID certificates, the NRC permits participants in the proceeding to access the E-Filing system to...

  14. 5 CFR 1201.14 - Electronic filing procedures.

    Science.gov (United States)

    2010-01-01

    ... form. (b) Matters subject to electronic filing. Subject to the registration requirement of paragraph (e) of this section, parties and representatives may use electronic filing (e-filing) to do any of the...). (d) Internet is sole venue for electronic filing. Following the instructions at e-Appeal Online, the...

  15. Establishment of data base files of thermodynamic data developed by OECD/NEA. Part 4. Addition of thermodynamic data for iron, tin and thorium

    International Nuclear Information System (INIS)

    Yoshida, Yasushi; Kitamura, Akira

    2014-12-01

    Thermodynamic data for compounds and complexes of elements with auxiliary species specialized in modeling requirements for safety assessments of radioactive waste disposal systems have been developed by the Thermochemical Data Base (TDB) project of the Nuclear Energy Agency in the Organization for Economic Co-operation and Development (OECD/NEA). Recently, thermodynamic data for aqueous complexes, solids and gases of thorium, tin and iron (Part 1) have been published in 2008, 2012 and 2013, respectively. These thermodynamic data have been selected on the basis of NEA’s guidelines which describe peer review and data selection, extrapolation to zero ionic strength, assignment of uncertainty, and temperature correction; therefore the selected data are considered to be reliable. The reliability of selected thermodynamic data of TDB developed by Japan Atomic Energy Agency (JAEA-TDB) has been confirmed by comparing with selected data by the NEA. For this comparison, text files of the selected data on some geochemical calculation programs are required. In the present report, the database files for the NEA’s TDB with addition of selected data for iron, tin and thorium to the previous files have been established for use of PHREEQC, Geochemist’s Workbench and EQ3/6. In addition, as an example of confirmation of quality, dominant species in iron TDB were compared in Eh-pH diagram and differences between JAEA-TDB and NEA-TDB were shown. Data base files established in the present study will be at the Website of thermodynamic, sorption and diffusion database in JAEA (http://migrationdb.jaea.go.jp/). A CD-ROM is attached as an appendix. (J.P.N.)

  16. REALISASI ISI KEPUTUSAN PESAMUAN AGUNG III MUDP BALI NO. 01/KEP/PSM-3 MDP BALI/X/2010 TERKAIT DENGAN ANAK PEREMPUAN TERMASUK BERHAK MEWARIS (STUDI KASUS DI KABUPATEN BULELENG

    Directory of Open Access Journals (Sweden)

    Ketut Sudiatmaka

    2016-08-01

    Full Text Available Abstrak Latar belakang penelitian ini adalah kajian terhadap status hukum perempuan Bali lemah dari segi pewarisan, karena menurut Hukum Adat Bali yang berhak mewaris hanyalah keturunan pria dan pihak keluarga pria dan anak angkat lelaki.. Wanita di dalam Hukum Adat Masyarakat Bali masih mengalami diskriminasi dari segi ketentuan hukum. Secara umum penelitian ini bertujuan untuk (1 untuk mengetahui bentuk pengambilan kebijakan dalam proses pengambilan keputusan adat perihal waris di kabupaten Buleleng; (2 untuk mengetahui realisasi isi keputusan MUDP Provinsi Bali No.01/Kep/PsM-3/MDP BALI/X/2010, 15 Oktober 2010 tentang perempuan Bali menerima 1/2 dari hak waris purusa setelah dipotong 30% untuk harta pusaka dan kepentingan pelestarian. (3 Untuk mengetahui pandangan dan keberterimaan perempuan di Kabupaten Buleleng terhadap implementasipsamuan agung III MUDP Bali; (4 untuk mengetahui pengaruh dari penetapan SK MUDP Provinsi Bali No.01/Kep/PsM-3/MDP BALI/X/2010, dan daya ikat bagi masyarakat adat di kabupaten Buleleng. Penelitian ini akan dilakukan selama 2 tahun, yaitu dari tahun 2015 sampai dengan tahun 2016. Luaran penelitian dijabarkan sebagai berikut: (1 luaran tahun I: perancangan dan pengembangan kebijakan tentang ketentuan adat yang lebih menjamin hak-hak perempuan secara hukum, dan Buku Ajar. (2 luaran tahun II: artikel ilmiah di jurnal nasional terakreditasi/internasional seperti jurnal Hukum Pandecta, dan rekomendasi yang berkaitan dengan rujukan draft naskah akademik yang dirancang oleh peneliti untuk diusulkan ke instansi terkait sebagai rujukan dalam penetapan hukum. Hasil penelitian Bentuk pengambilan keputusan di wilayah adat sudah menyesuaikan dengan uger-uger adat yang berlaku di masing-masing daerah di Kabupaten Buleleng tempat penelitian dilaksanakan. Untuk dapat dilaksanakan isi Pesamuan Agung III itu, dirasakan sangat perlu adanya perarem-perarem di masing-masing desa adat guna adanya pengenjuh awig yaitu penambahan atau

  17. The File System Interface is an Anachronism

    OpenAIRE

    Ellard, Daniel

    2003-01-01

    Contemporary file systems implement a set of abstractions and semantics that are suboptimal for many (if not most) purposes. The philosophy of using the simple mechanisms of the file system as the basis for a vast array of higher-level mechanisms leads to inefficient and incorrect implementations. We propose several extensions to the canonical file system model, including explicit support for lock files, indexed files, and resource forks, and the benefit of session semantics for write updates...

  18. Common cause failure investigations using the European Reliability Data System

    International Nuclear Information System (INIS)

    Games, A.M.; Breewood, M.; Amendola, A.; Keller, A.Z.

    1984-01-01

    The European Reliability Data System (ERDS) has provided data for use in investigations into common cause failures (CCFs) in nuclear power plants. These investigations have been made on two levels, at a system and inter-system level. Data have been used from the Component Event Data Bank and from the Licensee Event Report Files, both part of the ERDS. The two studies required different methodologies although both commenced with a temporal sorting procedure for the failure events. The studies demonstrated that different types of common cause failure necessitate different search algorithms, and thus a data search must be closely related to an appropriate CCF classification system, which in the first instance would not be based on causes of failure. (author)

  19. High School and Beyond: Twins and Siblings' File Users' Manual, User's Manual for Teacher Comment File, Friends File Users' Manual.

    Science.gov (United States)

    National Center for Education Statistics (ED), Washington, DC.

    These three users' manuals are for specific files of the High School and Beyond Study, a national longitudinal study of high school sophomores and seniors in 1980. The three files are computerized databases that are available on magnetic tape. As one component of base year data collection, information identifying twins, triplets, and some non-twin…

  20. Menggabungkan Beberapa File Dalam SPSS/PC

    Directory of Open Access Journals (Sweden)

    Syahrudji Naseh

    2012-09-01

    Full Text Available Pada dasamya piranti lunak komputer dapat dibagi ke dalam lima kelompok besar yaitu pengolah kata, spreadsheet database, statistika dan animasi/desktop. Masing-masing mempunyai kelebihan dan kekurangannya. Piranti lunak dBase 111+ yang merupakan piranti lunak paling populer dalam"database", hanya dapat menampung 128 variabel saja. Oleh karenanya pada suatu kuesioner yang besar seperti Susenas (Survei Sosial Ekonomi Nasional atau SKRT (Survei Kesehatan Rumah Tangga, datanya tidak dapat dijadikan satu "file". Biasanya dipecah menjadi banyak "file", umpamanya fileldbf, file2.dbf dan seterusnya.Masalahnya adalah bagaimana menggabung beberapa variabel yang ada di file1.dbf engan beberapa variabel yang ada di file5.dbf? Tulisan ini mencoba membahas masalah tersebut

  1. 76 FR 70651 - Fee for Filing a Patent Application Other Than by the Electronic Filing System

    Science.gov (United States)

    2011-11-15

    ... government; or (3) preempt tribal law. Therefore, a tribal summary impact statement is not required under... 0651-AC64 Fee for Filing a Patent Application Other Than by the Electronic Filing System AGENCY: United..., that is not filed by electronic means as prescribed by the Director of the United States Patent and...

  2. Land Use Change under Biofuel Policies and a Tax on Meat and Dairy Products: Considering Complexity in Agricultural Production Chains Matters

    Directory of Open Access Journals (Sweden)

    Ruth Delzeit

    2018-02-01

    Full Text Available Growing demand for meat and dairy products (MDP, biofuels, and scarcity of agricultural land are drivers of global land use competition. Impacts of policies targeting demand for MDP or biofuels have only been analysed separately. We use the computable general equilibrium model DART-BIO to investigate combined effects, since MDP and biofuel production are closely related via feestock use and co-production of animal feed. We implement four scenarios: (a a baseline scenario; (b halving MDP consumption in industrialised countries by a tax; (c abolishing current biofuel policies; and (d no exogenous land use change. We find that a MDP tax and exogenous land use change have larger effects on land use and food markets than biofuel policies. International trade is affected in all scenarios. With respect to combined effects of a MDP tax and biofuel policies, we find decreasing biodiesel but increasing bioethanol production. In addition, the MDP tax decreases the impact of biofuel policies on agricultural markets and land use. Our results highlight the importance of a detailed representation of different vegetable oils used in biodiesel production and related by-products. Finally, since the MDP tax increases the use of fossil fuels, the net climate mitigation potentials of such a tax should be investigated further.

  3. A mentor development program for clinical translational science faculty leads to sustained, improved confidence in mentoring skills.

    Science.gov (United States)

    Feldman, Mitchell D; Steinauer, Jody E; Khalili, Mandana; Huang, Laurence; Kahn, James S; Lee, Kathryn A; Creasman, Jennifer; Brown, Jeanette S

    2012-08-01

    Mentorship is crucial for academic productivity and advancement for clinical and translational (CT) science faculty. However, little is known about the long-term effects of mentor training programs. The University of California, San Francisco (UCSF), Clinical and Translational Science Institute launched a Mentor Development Program (MDP) in 2007 for CT faculty. We report on an evaluation of the first three cohorts of graduates from the MDP. In 2010, all Mentors in Training (MITs) who completed the MDP from 2007 to 2009 (n= 38) were asked to complete an evaluation of their mentoring skills and knowledge; all MITs (100%) completed the evaluation. Two-thirds of MDP graduates reported that they often apply knowledge, attitudes, or skills obtained in the MDP to their mentoring. Nearly all graduates (97%) considered being a mentor important to their career satisfaction. Graduates were also asked about the MDP's impact on specific mentoring skills; 95% agreed that the MDP helped them to become a better mentor and to focus their mentoring goals. We also describe a number of new initiatives to support mentoring at UCSF that have evolved from the MDP. To our knowledge, this is the first evaluation of the long-term impact of a mentor training program for CT researchers. © 2012 Wiley Periodicals, Inc.

  4. Protein binding of N-2-mercaptoethyl-1,3-diaminopropane via mixed disulfide formation after oral administration of WR 2721

    Energy Technology Data Exchange (ETDEWEB)

    Tabachnik, N.F.; Blackburn, P.; Peterson, C.M.; Cerami, A.

    1982-02-01

    Earlier studies have shown that WR 2721 (H2N-(CH2)3-NH(CH2)2SPO3H2) is converted to its free thiol form, N-2-mercaptoethyl-1,3-diaminopropane (MDP), at the acidic pH of the stomach. MDP is a radioprotective compound and a mucolytic agent capable of decreasing sputum viscosity in the lungs of patients with cystic fibrosis. Conversion of WR 2721 and MDP to the corresponding sulfonic acid (MDP-SO3H) permits quantitative determination of these compounds in physiological fluids by use of an automatic amino acid analyzer. After oral administration of WR 2721 to human patients and rabbits it is converted to MDP and the free thiol form of the drug associates with plasma proteins by mixed disulfide linkage. The plasma proteins serve as a depot and reservoir of MDP for potential exchange at the tissues. When incubated with whole sputum or with purified mucin solutions in vitro, MDP decreased the viscosity of these solutions by reduction of the accessible disulfide bonds of the mucin molecule and was subsequently found in mixed disulfide association with the mucin molecule. The association of MDP with proteins via mixed disulfide linkage has important implications for the development of optimal dose regimens for administration of WR 2721 to patients.

  5. Protein binding of N-2-mercaptoethyl-1,3-diaminopropane via mixed disulfide formation after oral administration of WR 2721

    International Nuclear Information System (INIS)

    Tabachnik, N.F.; Blackburn, P.; Peterson, C.M.; Cerami, A.

    1982-01-01

    Earlier studies have shown that WR 2721 [H2N-(CH2)3-NH(CH2)2SPO3H2] is converted to its free thiol form, N-2-mercaptoethyl-1,3-diaminopropane (MDP), at the acidic pH of the stomach. MDP is a radioprotective compound and a mucolytic agent capable of decreasing sputum viscosity in the lungs of patients with cystic fibrosis. Conversion of WR 2721 and MDP to the corresponding sulfonic acid (MDP-SO3H) permits quantitative determination of these compounds in physiological fluids by use of an automatic amino acid analyzer. After oral administration of WR 2721 to human patients and rabbits it is converted to MDP and the free thiol form of the drug associates with plasma proteins by mixed disulfide linkage. The plasma proteins serve as a depot and reservoir of MDP for potential exchange at the tissues. When incubated with whole sputum or with purified mucin solutions in vitro, MDP decreased the viscosity of these solutions by reduction of the accessible disulfide bonds of the mucin molecule and was subsequently found in mixed disulfide association with the mucin molecule. The association of MDP with proteins via mixed disulfide linkage has important implications for the development of optimal dose regimens for administration of WR 2721 to patients

  6. Correlation of serum prostate specific antigen levels and Tc-99m mdp bone scintigraphy in newly diagnosed patients with prostrate cancer (abstract)

    International Nuclear Information System (INIS)

    Rauf, M.; Khan, S.M.; Khan, A.A.; Ahmad, S.; Knob, G.; Shah, S.; Khan, A.A.

    1998-01-01

    The aim of the study was to evaluate the correlation between serum prostate specific antigen (PSA) level and bone scintigraphy in newly diagnosed untreated prostate cancer patients. The probability of a positive bone scan for metastases was analyzed for different threshold values of prostate specific antigen (PSA), acid phosphastase and alkaline phosphates. Fifty four newly diagnosed untreated prostate cancer patients (mean age, 67 years range, 41 to 94) were included in this study. In each case serum PSA, acid phosphatase and alkaline phosphatase measurements were performed followed by whole body Technetium-99m MDP bone scan. The positive predictive value of serum PSA level for bone metastases at the threshold of 10 ng/ml was 70% whereas the same threshold level of PSA gave a negative predictive value of 100%. We used receiver operating characteristics (ROC) analysis to examine the power of predictive value of each serum test, in predicting the results of the bone scan. We also applied regression analysis for the assessment of correlation between the levels of tumor markers and the extent of bone pathology. It was concluded that bone scintigraphy seems to be unnecessary in evaluation of newly diagnosed untreated prostate cancer in patients with no clinical signs of bone pathology and serum PSA levels of equal to or less than 10 ng/ml. (author)

  7. Uptake and localization of sup(99m)technetium-methylene-diphosphonate in bone

    International Nuclear Information System (INIS)

    Savelkoul, T.J.F.

    1984-01-01

    The author investigated the uptake and localization of 99m-technetium-methylene-diphosphonate (99m-Tc-MDP) in bone, to develop a sensitive mean for the detection of early osseous disease. In an electrolysis procedure without the presence of contaminating reductants a 99m-Tc-MDP complex is formed with clear bone-seeking properties. The scans performed in experimental animals are comparable in quality with 99m-Tc(Sn)-MDP scans. The uptake of 99m-Tc-MDP is faster and higher than the uptake of reduced hydrolyzed 99m-Tc. Uptake of 99m-Tc(Sn)-MDP in bone can only take place after decomposition of the complex. As 99m-Tc-MDP is taken up as a unit, this may be a better agent to evaluate the osteoblastic activity in the skeleton. (Auth./R.B.)

  8. Earnings Public-Use File, 2006

    Data.gov (United States)

    Social Security Administration — Social Security Administration released Earnings Public-Use File (EPUF) for 2006. File contains earnings information for individuals drawn from a systematic random...

  9. 12 CFR 509.10 - Filing of papers.

    Science.gov (United States)

    2010-01-01

    ... 12 Banks and Banking 5 2010-01-01 2010-01-01 false Filing of papers. 509.10 Section 509.10 Banks... IN ADJUDICATORY PROCEEDINGS Uniform Rules of Practice and Procedure § 509.10 Filing of papers. (a) Filing. Any papers required to be filed, excluding documents produced in response to a discovery request...

  10. 47 CFR 61.14 - Method of filing publications.

    Science.gov (United States)

    2010-10-01

    ... 47 Telecommunication 3 2010-10-01 2010-10-01 false Method of filing publications. 61.14 Section 61...) TARIFFS Rules for Electronic Filing § 61.14 Method of filing publications. (a) Publications filed... date of a publication received by the Electronic Tariff Filing System will be determined by the date...

  11. 12 CFR 263.10 - Filing of papers.

    Science.gov (United States)

    2010-01-01

    ... 12 Banks and Banking 3 2010-01-01 2010-01-01 false Filing of papers. 263.10 Section 263.10 Banks... OF PRACTICE FOR HEARINGS Uniform Rules of Practice and Procedure § 263.10 Filing of papers. (a) Filing. Any papers required to be filed, excluding documents produced in response to a discovery request...

  12. 12 CFR 308.10 - Filing of papers.

    Science.gov (United States)

    2010-01-01

    ... 12 Banks and Banking 4 2010-01-01 2010-01-01 false Filing of papers. 308.10 Section 308.10 Banks... AND PROCEDURE Uniform Rules of Practice and Procedure § 308.10 Filing of papers. (a) Filing. Any papers required to be filed, excluding documents produced in response to a discovery request pursuant to...

  13. 29 CFR 1981.103 - Filing of discrimination complaint.

    Science.gov (United States)

    2010-07-01

    ... constitute the violations. (c) Place of filing. The complaint should be filed with the OSHA Area Director... or she has been discriminated against by an employer in violation of the Act may file, or have filed..., but may be filed with any OSHA officer or employee. Addresses and telephone numbers for these...

  14. 77 FR 66458 - Combined Notice of Filings #1

    Science.gov (United States)

    2012-11-05

    ... Service Company of Colorado. Description: 2012--10--26 PSCo MBR Filing to be effective 12/26/ 2012. Filed...--SPS MBR Filing to be effective 12/26/2012. Filed Date: 10/26/12. Accession Number: 20121026-5123...: Revised Application for MBR Authorization to be effective 10/16/2012. Filed Date: 10/25/12. Accession...

  15. 75 FR 66075 - Combined Notice of Filings #1

    Science.gov (United States)

    2010-10-27

    ....12: Baseline MBR Concurrence to be effective 10/8/2010. Filed Date: 10/19/2010. Accession Number... Company submits tariff filing per 35.12: Baseline MBR Concurrence to be effective 10/8/2010. Filed Date... Power Company submits tariff filing per 35.12: Baseline MBR Concurrence to be effective 10/8/2010. Filed...

  16. The Global File System

    Science.gov (United States)

    Soltis, Steven R.; Ruwart, Thomas M.; OKeefe, Matthew T.

    1996-01-01

    The global file system (GFS) is a prototype design for a distributed file system in which cluster nodes physically share storage devices connected via a network-like fiber channel. Networks and network-attached storage devices have advanced to a level of performance and extensibility so that the previous disadvantages of shared disk architectures are no longer valid. This shared storage architecture attempts to exploit the sophistication of storage device technologies whereas a server architecture diminishes a device's role to that of a simple component. GFS distributes the file system responsibilities across processing nodes, storage across the devices, and file system resources across the entire storage pool. GFS caches data on the storage devices instead of the main memories of the machines. Consistency is established by using a locking mechanism maintained by the storage devices to facilitate atomic read-modify-write operations. The locking mechanism is being prototyped in the Silicon Graphics IRIX operating system and is accessed using standard Unix commands and modules.

  17. 99mTc-MDP Bone Scan Findings in Various Clinical Stages of Malignancies

    International Nuclear Information System (INIS)

    Yoon, Hwi Joong; Lee, Myung Chul; Cho, Bo Yeon; Kim, Noe Kyeong; Koh, Chang Soon

    1981-01-01

    Bone scans with 99m Tc-MDP (methylene diphosphonate) were obtained and analysed in 574 from April, 1979 to June, 1931. Clinical staging was done in all patients without bone scan information and compared with bone scan to determine the predictive value of bone scanning. 1) Primary site of the malignancies were lung in 152, breast in 97, stomach in 43, colon in 15, esophagus in 9, liver and pancreas in 11, kidney in 14, bladder in 27, prostate in 22, thyroid in 20, skin in 11, bone in 9, head and neck in 36, ovary and uterus in 17, hematopoietic and lymphoretic ular system in 33, nervous system in 10, and others in 9 cases. Primary site was not defined in 39 cases. 2) Bone scans were positive in 186 cases (32.4%), which, included 48 cases (31.6%) of lung cancer, 27 cases (27.8%) of breast cancer, 12 cases (28%) of stomach cancer, 6 cases (40%) of colon cancer, 6 cases (43%) of kidney tumor, 4 cases (15%) of bladder cancer, 14 cases (64%) of prostate cancer, 3 cases (15%) of thyroid cancer and 66 other cases. 3) Bone scans were suspicious in 64 cases (11.2%) which included 29 cases (19.1%) of lung cancer, 10 cases (10.3%) of breast cancer, 4 cases (9.3%) of stomach cancer, one case (7%) of colon cancer, 3 cases (11%) of bladder cancer, 2 cases (10%) of thyroid cancer and 15 other cases. 4) Out of 121 cases with early stage of malignancy (which included 20 cases of lung cancer in stage I, II, 38 cases of breast cancer, 13 cases of stomach cancer, 8 cases of kidney tumor, 14 cases of thyroid cancer in stage I-III, and 6 cases of colon cancer, 14 cases of bladder cancer, 8 cases of prostate cancer in stage A-C, bone scans were positive in 5 cases (4.1%) which included 3 cases of lung cancer one case of breast cancer and one case of prostate cancer, and considered as further advanced stage, Out of 121 cases with early stage of malignancy, bone scans were suspicious in 21 cases (17.4%) which included 9 cases of lung cancer, 4 cases of breast cancer, 2 cases of stomach

  18. Mixed-Media File Systems

    NARCIS (Netherlands)

    Bosch, H.G.P.

    1999-01-01

    This thesis addresses the problem of implementing mixed-media storage systems. In this work a mixed-media file system is defined to be a system that stores both conventional (best-effort) file data and real-time continuous-media data. Continuous-media data is usually bulky, and servers storing and

  19. 76 FR 58257 - Combined Notice of Filings #2

    Science.gov (United States)

    2011-09-20

    ... Hills Wind Farm, LLC MBR Tariff to be effective 10/31/2007. Filed Date: 09/12/2011. Accession Number... filing per 35.1: Smoky Hills Wind Project II, LLC MBR Tariff to be effective 10/20/2008. Filed Date: 09..., LLC submits tariff filing per 35.1: Enel Stillwater, LLC MBR Tariff to be effective 12/5/2008. Filed...

  20. 77 FR 28592 - Combined Notice of Filings #1

    Science.gov (United States)

    2012-05-15

    ...: Middletown MBR Application to be effective 5/8/2012. Filed Date: 5/7/12. Accession Number: 20120507-5128..., LLC. Description: Southern Energy Initial MBR Filing to be effective 5/ 7/2012. Filed Date: 5/8/12... Company submits tariff filing per 35.37: MBR Triennial Filing--1st Rev MBR to be effective 9/30/2010...

  1. 76 FR 59676 - Combined Notice of Filings #1

    Science.gov (United States)

    2011-09-27

    ... MBR Tariff to be effective 10/1/2011. Filed Date: 09/16/2011. Accession Number: 20110916-5146. Comment... 35.1: ONEOK Energy Services Company Baseline MBR Filing to be effective 9/16/2011. Filed Date: 09/16... Services Order No. 697 Compliance Filing of MBR Tariff to be effective 9/16/2011. Filed Date: 09/16/2011...

  2. K-file vs ProFiles in cleaning capacity and instrumentation time in primary molar root canals: An in vitro study

    Directory of Open Access Journals (Sweden)

    N Madan

    2011-01-01

    Full Text Available Objectives: This study compares the efficiency of manual K-files and rotary ProFiles in cleaning capacity and instrumentation time in primary molar root canals. Materials and Methods: Seventy-five maxillary and mandibular primary molar root canals were instrumented with ProFiles and K-files in the step-back manner from size #10 to #40. The teeth were decalcified, dehydrated and cleared, and analyzed for the presence of dye remaining on the root canal walls, which served as an evidence of cleaning capacity of both the techniques. Results: The results showed a significant difference in the cleaning capacity of the root canals with ProFiles and K-files, in apical and coronal thirds of the root canal. ProFiles have been found to be more efficient in cleaning the coronal thirds and K-files in cleaning apical thirds of the root canals. Both the techniques were almost equally effective in cleaning the middle thirds of the canals. The time taken during the cleaning of the root canals appeared to be statistically shorter with K-files than profiles.

  3. IMPLEMENTASI HAK WARIS PEREMPUAN KE DALAM AWIG-AWIG DESA PAKRAMAN

    Directory of Open Access Journals (Sweden)

    Ida Ayu Sadnyini

    2016-09-01

    Full Text Available Women in Bali Customary Law have not received legal heir protection. This is because the Hindu community in Bali embraces patrilineal kinship system. In the development of the Assembly Pakraman (MDP Bali Number III of 2010, they have taken the initiative to give women the right to inherit the extent of the joint property of her parents. As the MDP decree has not been implemented into awig awig Pakraman, women are still in the same position. This condition causes the researcher to study the "Implementation Inheritance Rights of Women into Awig-Awig Pakraman". The issues that will be studied as follows: How do women's inheritance rights in Hindu society in Bali before the issued MDP Bali? How is the implementation of the MDP Bali Decree No.III of 2010 into awig awig Pakraman? This research is an empirical research. Analysis of primary data and secondary data is done using qualitative descriptive method and legal arguments are then provided. Having conducted research on awig awig Pakraman 2014, none have implemented the MDP decree into awig-awig. Continuous socialization is necessary so that the indigenous elders and Hindu community in Bali implement the MDP decree to provide what the rights of women. Perempuan dalam Hukum Adat Bali, belum mendapat perlindungan hukum dalam mewaris. Hal ini disebabkan karena masyarakat Hindu di Bali menganut sistem kekeluargaan patrilineal. Dalam perkembangannya Majelis Desa Pakraman (MDP Bali Nomor III Tahun 2010 telah mengambil inisiatif untuk memberikan hak  mewaris kepada perempuan sebatas harta bersama dari orang tuanya. Putusan MDP tersebut belum di implementasikan kedalam awig-awig desa pakraman, menyebabkan perempuan masih dalam posisi yang sama. Keadaan inilah yang menyebabkan peneliti ingin mengkaji  “Implementasi Keputusan MDP Bali Nomor III Tahun 2010 Tentang Hak Waris Perempuan Ke Dalam Awig-Awig Desa Pakraman”. Adapun permasalahan yang akan dikaji sebagai berikut: Bagaimanakah hak waris anak

  4. Differentiation between peri-prosthetic infection and aseptic loosening using quantitative analysis of triphasic 99Tcm-MDP bone scintigraphy

    International Nuclear Information System (INIS)

    Li Xinxin; Zhang Yanyan; Zhang Weifang; Mao Yuan; Zhao Meixin

    2013-01-01

    Objective: To differentiate between peri-prosthetic infection and aseptic loosening using quantitative analysis of triphasic bone scintigraphy. Methods: Twenty-eight patients (9 males, 19 females; mean age 67.5 years, range 49-80 years) with recurrent joint pain after arthroplasty were retrospectively assessed. All patients underwent triphasic bone scintigraphy. ROI of each joint was drawn and the ratios of affected to unaffected side were calculated. The ratios of blood flow phase, blood pool phase, static phase, C-reactive protein (CRP) and erythrocyte sedimentation (ESR) were quantitatively analyzed by ROC curve. The final diagnosis was based on microbiological and histological examinations. The optimal cut-off value was chosen based on the ideal sensitivity and specificity. Results: Nine patients were diagnosed as septic loosening, 17 patients aseptic loosening, 1 patient bursitis of hip joint and 1 patient suture reaction. Taking the positive results of blood flow phase or blood pool phase as standard for diagnosing septic loosening, the sensitivity, specificity and accuracy of bone scintigraphy were 7/9, 78.9% (15/19) and 78.6% (22/28), respectively. The AUC of blood pool phase was 0.942, and the sensitivity and specificity were 8/9 and 78.9% (15/19), respectively, with the optimal cut-off value of 1.40. The AUCs of blood flow ratio and CRP were 0.816 and 0.795, with cut-off values of 1.53 and 1.20, respectively. The AUCs of static phase ratio and ESR were 0.474 and 0.722, respectively, both P>0.05. Conclusions: For the diagnosis of septic loosening, quantitative analysis of triphasic 99 Tc m -MDP bone scintigraphy, particularly with the ratio of blood pool phase, is more accurate than qualitative analysis. (authors)

  5. Curved canals: Ancestral files revisited

    Directory of Open Access Journals (Sweden)

    Jain Nidhi

    2008-01-01

    Full Text Available The aim of this article is to provide an insight into different techniques of cleaning and shaping of curved root canals with hand instruments. Although a plethora of root canal instruments like ProFile, ProTaper, LightSpeed ® etc dominate the current scenario, the inexpensive conventional root canal hand files such as K-files and flexible files can be used to get optimum results when handled meticulously. Special emphasis has been put on the modifications in biomechanical canal preparation in a variety of curved canal cases. This article compiles a series of clinical cases of root canals with curvatures in the middle and apical third and with S-shaped curvatures that were successfully completed by employing only conventional root canal hand instruments.

  6. 76 FR 40905 - Turnagain Arm Tidal Electric Energy Project; Notice of Intent To File License Application, Filing...

    Science.gov (United States)

    2011-07-12

    ... Tidal Electric Energy Project; Notice of Intent To File License Application, Filing of Pre-Application....: 13509-001. c. Dated Filed: May 11, 2011. d. Submitted By: Turnagain Arm Tidal Energy Corporation. e. Name of Project: Turnagain Arm Tidal Electric Energy Project. f. Location: Of the Upper Cook Inlet off...

  7. 77 FR 58370 - Pennamaquan Tidal Power LLC; Notice of Intent To File License Application, Filing of Pre...

    Science.gov (United States)

    2012-09-20

    ... Tidal Power LLC; Notice of Intent To File License Application, Filing of Pre-Application Document (PAD... Filed: July 19, 2012. d. Submitted By: Pennamaquan Tidal Power LLC (Pennamaquan Power). e. Name of Project: Pennamaquan Tidal Power Plant Project. f. Location: On the Pennamaquan River at the entrance to...

  8. 75 FR 61474 - Juneau Hydropower, Inc.; Notice of Intent To File License Application, Filing of Pre-Application...

    Science.gov (United States)

    2010-10-05

    ... Hydropower, Inc.; Notice of Intent To File License Application, Filing of Pre-Application Document, and....: 13563-001. c. Dated Filed: July 28, 2010. d. Submitted By: Juneau Hydropower, Inc. e. Name of Project... Commission's regulations. h. Potential Applicant Contact: Duff W. Mitchell, Juneau Hydropower, Inc., P.O. Box...

  9. Evaluated nuclear-data file for niobium

    International Nuclear Information System (INIS)

    Smith, A.B.; Smith, D.L.; Howerton, R.J.

    1985-03-01

    A comprehensive evaluated nuclear-data file for elemental niobium is provided in the ENDF/B format. This file, extending over the energy range 10 -11 -20 MeV, is suitable for comprehensive neutronic calculations, particulary those dealing with fusion-energy systems. It also provides dosimetry information. Attention is given to the internal consistancy of the file, energy balance, and the quantitative specification of uncertainties. Comparisons are made with experimental data and previous evaluated files. The results of integral tests are described and remaining outstanding problem areas are cited. 107 refs

  10. Data_files_Reyes_EHP_phthalates

    Data.gov (United States)

    U.S. Environmental Protection Agency — The file contains three files in comma separated values (.csv) format. “Reyes_EHP_Phthalates_US_metabolites.csv” contains information about the National Health and...

  11. 75 FR 51994 - Combined Notice of Filings

    Science.gov (United States)

    2010-08-24

    ...: Panther Interstate Pipeline Energy, LLC. Description: Panther Interstate Pipeline Energy, LLC submits tariff filing per 154.203: Panther Baseline eTariff Filing to be effective 8/ 12/2010. Filed Date: 08/13...

  12. Asymmetric Programming: A Highly Reliable Metadata Allocation Strategy for MLC NAND Flash Memory-Based Sensor Systems

    Science.gov (United States)

    Huang, Min; Liu, Zhaoqing; Qiao, Liyan

    2014-01-01

    While the NAND flash memory is widely used as the storage medium in modern sensor systems, the aggressive shrinking of process geometry and an increase in the number of bits stored in each memory cell will inevitably degrade the reliability of NAND flash memory. In particular, it's critical to enhance metadata reliability, which occupies only a small portion of the storage space, but maintains the critical information of the file system and the address translations of the storage system. Metadata damage will cause the system to crash or a large amount of data to be lost. This paper presents Asymmetric Programming, a highly reliable metadata allocation strategy for MLC NAND flash memory storage systems. Our technique exploits for the first time the property of the multi-page architecture of MLC NAND flash memory to improve the reliability of metadata. The basic idea is to keep metadata in most significant bit (MSB) pages which are more reliable than least significant bit (LSB) pages. Thus, we can achieve relatively low bit error rates for metadata. Based on this idea, we propose two strategies to optimize address mapping and garbage collection. We have implemented Asymmetric Programming on a real hardware platform. The experimental results show that Asymmetric Programming can achieve a reduction in the number of page errors of up to 99.05% with the baseline error correction scheme. PMID:25310473

  13. Asymmetric Programming: A Highly Reliable Metadata Allocation Strategy for MLC NAND Flash Memory-Based Sensor Systems

    Directory of Open Access Journals (Sweden)

    Min Huang

    2014-10-01

    Full Text Available While the NAND flash memory is widely used as the storage medium in modern sensor systems, the aggressive shrinking of process geometry and an increase in the number of bits stored in each memory cell will inevitably degrade the reliability of NAND flash memory. In particular, it’s critical to enhance metadata reliability, which occupies only a small portion of the storage space, but maintains the critical information of the file system and the address translations of the storage system. Metadata damage will cause the system to crash or a large amount of data to be lost. This paper presents Asymmetric Programming, a highly reliable metadata allocation strategy for MLC NAND flash memory storage systems. Our technique exploits for the first time the property of the multi-page architecture of MLC NAND flash memory to improve the reliability of metadata. The basic idea is to keep metadata in most significant bit (MSB pages which are more reliable than least significant bit (LSB pages. Thus, we can achieve relatively low bit error rates for metadata. Based on this idea, we propose two strategies to optimize address mapping and garbage collection. We have implemented Asymmetric Programming on a real hardware platform. The experimental results show that Asymmetric Programming can achieve a reduction in the number of page errors of up to 99.05% with the baseline error correction scheme.

  14. 75 FR 49923 - Combined Notice of Filings #1

    Science.gov (United States)

    2010-08-16

    ... filing per 35.12: KCP&L-GMO Baseline Filing (Market-Based Volume 28) to be effective 8/2/2010. Filed Date...: KCP&L Greater Missouri Operations Company submits tariff filing per 35.12: GMO Volume 33 (Cost-Based...

  15. Radiology Teaching Files on the Internet

    International Nuclear Information System (INIS)

    Lim, Eun Chung; Kim, Eun Kyung

    1996-01-01

    There is increasing attention about radiology teaching files on the Internet in the field of diagnostic radiology. The purpose of this study was to aid in the creation of new radiology teaching file by analysing the present radiology teaching file sites on the Internet with many aspects and evaluating images on those sites, using Macintosh II ci compute r, 28.8kbps TelePort Fax/Modem, Netscape Navigator 2.0 software. The results were as follow : 1. Analysis of radiology teaching file sites (1) Country distribution was the highest in USA (57.5%). (2) Average number of cases was 186 cases and radiology teaching file sites with search engine were 9 sites (22.5%). (3) At the method of case arrangement, anatomic area type and diagnosis type were found at the 10 sites (25%) each, question and answer type was found at the 9 sites (22.5%). (4) Radiology teaching file sites with oro-maxillofacial disorder were 9 sites (22.5%). (5) At the image format, GIF format was found at the 14 sites (35%), and JPEG format found at the 14 sites (35%). (6) Created year was the highest in 1995 (43.7%). (7) Continuing case upload was found at the 35 sites (87.5%). 2. Evaluation of images on the radiology teaching files (1) Average file size of GIF format (71 Kbyte) was greater than that of JPEG format (24 Kbyte). (P<0.001) (2) Image quality of GIF format was better than that of JPEG format. (P<0.001)

  16. Detection Of Alterations In Audio Files Using Spectrograph Analysis

    Directory of Open Access Journals (Sweden)

    Anandha Krishnan G

    2015-08-01

    Full Text Available The corresponding study was carried out to detect changes in audio file using spectrograph. An audio file format is a file format for storing digital audio data on a computer system. A sound spectrograph is a laboratory instrument that displays a graphical representation of the strengths of the various component frequencies of a sound as time passes. The objectives of the study were to find the changes in spectrograph of audio after altering them to compare altering changes with spectrograph of original files and to check for similarity and difference in mp3 and wav. Five different alterations were carried out on each audio file to analyze the differences between the original and the altered file. For altering the audio file MP3 or WAV by cutcopy the file was opened in Audacity. A different audio was then pasted to the audio file. This new file was analyzed to view the differences. By adjusting the necessary parameters the noise was reduced. The differences between the new file and the original file were analyzed. By adjusting the parameters from the dialog box the necessary changes were made. The edited audio file was opened in the software named spek where after analyzing a graph is obtained of that particular file which is saved for further analysis. The original audio graph received was combined with the edited audio file graph to see the alterations.

  17. Multinomial-exponential reliability function: a software reliability model

    International Nuclear Information System (INIS)

    Saiz de Bustamante, Amalio; Saiz de Bustamante, Barbara

    2003-01-01

    The multinomial-exponential reliability function (MERF) was developed during a detailed study of the software failure/correction processes. Later on MERF was approximated by a much simpler exponential reliability function (EARF), which keeps most of MERF mathematical properties, so the two functions together makes up a single reliability model. The reliability model MERF/EARF considers the software failure process as a non-homogeneous Poisson process (NHPP), and the repair (correction) process, a multinomial distribution. The model supposes that both processes are statistically independent. The paper discusses the model's theoretical basis, its mathematical properties and its application to software reliability. Nevertheless it is foreseen model applications to inspection and maintenance of physical systems. The paper includes a complete numerical example of the model application to a software reliability analysis

  18. The crystallographic information file (CIF): A new standard archive file for crystallography

    International Nuclear Information System (INIS)

    Hall, S.R.; Allen, F.H.; Brown, I.D.

    1991-01-01

    The specification of a new standard Crystallographic Information File (CIF) is described. Its development is based on the Self-Defining Text Archieve and Retrieval (STAR) procedure. The CIF is a general, flexible and easily extensible free-format archive file; it is human and machine readable and can be edited by a simple editor. The CIF is designed for the electronic transmission of crystallographic data between individual laboratories, journals and databases: It has been adopted by the International Union of Crystallography as the recommended medium for this purpose. The file consists of data names and data items, together with a loop facility for repeated items. The data names, constructed hierarchically so as to form data categories, are self-descriptive within a 32-character limit. The sorted list of data names, together with their precise definitions, constitutes the CIF dictionary (core version 1991). The CIF core dictionary is presented in full and covers the fundamental and most commonly used data items relevant to crystal structure analysis. The dictionary is also available as an electronic file suitable for CIF computer applications. Future extensions to the dictionary will include data items used in more specialized areas of crystallography. (orig.)

  19. 77 FR 34030 - BOST1 Hydroelectric LLC; Notice of Intent To File License Application, Filing of Pre-Application...

    Science.gov (United States)

    2012-06-08

    ... Hydroelectric LLC; Notice of Intent To File License Application, Filing of Pre-Application Document, and.... Date Filed: March 21, 2012. d. Submitted By: BOST1 Hydroelectric LLC (BOST1). e. Name of Project: Coon Rapids Dam Hydroelectric Project. f. Location: Mississippi River in Hennepin and Anoka counties...

  20. High-Performance, Multi-Node File Copies and Checksums for Clustered File Systems

    Science.gov (United States)

    Kolano, Paul Z.; Ciotti, Robert B.

    2012-01-01

    Modern parallel file systems achieve high performance using a variety of techniques, such as striping files across multiple disks to increase aggregate I/O bandwidth and spreading disks across multiple servers to increase aggregate interconnect bandwidth. To achieve peak performance from such systems, it is typically necessary to utilize multiple concurrent readers/writers from multiple systems to overcome various singlesystem limitations, such as number of processors and network bandwidth. The standard cp and md5sum tools of GNU coreutils found on every modern Unix/Linux system, however, utilize a single execution thread on a single CPU core of a single system, and hence cannot take full advantage of the increased performance of clustered file systems. Mcp and msum are drop-in replacements for the standard cp and md5sum programs that utilize multiple types of parallelism and other optimizations to achieve maximum copy and checksum performance on clustered file systems. Multi-threading is used to ensure that nodes are kept as busy as possible. Read/write parallelism allows individual operations of a single copy to be overlapped using asynchronous I/O. Multinode cooperation allows different nodes to take part in the same copy/checksum. Split-file processing allows multiple threads to operate concurrently on the same file. Finally, hash trees allow inherently serial checksums to be performed in parallel. Mcp and msum provide significant performance improvements over standard cp and md5sum using multiple types of parallelism and other optimizations. The total speed-ups from all improvements are significant. Mcp improves cp performance over 27x, msum improves md5sum performance almost 19x, and the combination of mcp and msum improves verified copies via cp and md5sum by almost 22x. These improvements come in the form of drop-in replacements for cp and md5sum, so are easily used and are available for download as open source software at http://mutil.sourceforge.net.

  1. reliability reliability

    African Journals Online (AJOL)

    eobe

    Corresponding author, Tel: +234-703. RELIABILITY .... V , , given by the code of practice. However, checks must .... an optimization procedure over the failure domain F corresponding .... of Concrete Members based on Utility Theory,. Technical ...

  2. 75 FR 68340 - Combined Notice of Filings # 1

    Science.gov (United States)

    2010-11-05

    ... Project, LP; Southern Company--Florida LLC. Description: Report of Non-Material Change in Estimated Coal... Energy Ohio, Inc. submits tariff filing per 35: Compliance Filing to be effective 7/29/2010. Filed Date..., Inc. Description: Midwest Independent Transmission System Operator, Inc. submits tariff filing per 35...

  3. Measuring reliability under epistemic uncertainty: Review on non-probabilistic reliability metrics

    Directory of Open Access Journals (Sweden)

    Kang Rui

    2016-06-01

    Full Text Available In this paper, a systematic review of non-probabilistic reliability metrics is conducted to assist the selection of appropriate reliability metrics to model the influence of epistemic uncertainty. Five frequently used non-probabilistic reliability metrics are critically reviewed, i.e., evidence-theory-based reliability metrics, interval-analysis-based reliability metrics, fuzzy-interval-analysis-based reliability metrics, possibility-theory-based reliability metrics (posbist reliability and uncertainty-theory-based reliability metrics (belief reliability. It is pointed out that a qualified reliability metric that is able to consider the effect of epistemic uncertainty needs to (1 compensate the conservatism in the estimations of the component-level reliability metrics caused by epistemic uncertainty, and (2 satisfy the duality axiom, otherwise it might lead to paradoxical and confusing results in engineering applications. The five commonly used non-probabilistic reliability metrics are compared in terms of these two properties, and the comparison can serve as a basis for the selection of the appropriate reliability metrics.

  4. 77 FR 105 - Combined Notice of Filings #2

    Science.gov (United States)

    2012-01-03

    ... tariff filing per 35.17(b): Effective Date Change for ``Fully Integrated'' DR Rules to be effective 6/1... Numbers: ER12-10-001. Applicants: Energy International Power Marketing. Description: Energy International Power Marketing submits tariff filing per 35: EIP Compliance Filing to be effective 10/3/2011. Filed...

  5. Incidence of Apical Crack Initiation during Canal Preparation using Hand Stainless Steel (K-File) and Hand NiTi (Protaper) Files.

    Science.gov (United States)

    Soni, Dileep; Raisingani, Deepak; Mathur, Rachit; Madan, Nidha; Visnoi, Suchita

    2016-01-01

    To evaluate the incidence of apical crack initiation during canal preparation with stainless steel K-files and hand protaper files (in vitro study). Sixty extracted mandibular premo-lar teeth are randomly selected and embedded in an acrylic tube filled with autopolymerizing resin. A baseline image of the apical surface of each specimen was recorded under a digital microscope (80×). The cervical and middle thirds of all samples were flared with #2 and #1 Gates-Glidden (GG) drills, and a second image was recorded. The teeth were randomly divided into four groups of 15 teeth each according to the file type (hand K-file and hand-protaper) and working length (WL) (instrumented at WL and 1 mm less than WL). Final image after dye penetration and photomicrograph of the apical root surface were digitally recorded. Maximum numbers of cracks were observed with hand protaper files compared with hand K-file at the WL and 1 mm short of WL. Chi-square testing revealed a highly significant effect of WL on crack formation at WL and 1 mm short of WL (p = 0.000). Minimum numbers of cracks at WL and 1 mm short of WL were observed with hand K-file and maximum with hand protaper files. Soni D, Raisingani D, Mathur R, Madan N, Visnoi S. Incidence of Apical Crack Initiation during Canal Preparation using Hand Stainless Steel (K-File) and Hand NiTi (Protaper) Files. Int J Clin Pediatr Dent 2016;9(4):303-307.

  6. Design and application of remote file management system

    International Nuclear Information System (INIS)

    Zhu Haijun; Liu Dekang; Shen liren

    2006-01-01

    File transfer protocol can help users transfer files between computers on internet. FTP can not fulfill the needs of users in special occasions, so it needs programmer define file transfer protocol himself based on users. The method or realization and application for user-defined file transfer protocol is introduced. (authors)

  7. 37 CFR 360.21 - Time of filing.

    Science.gov (United States)

    2010-07-01

    ... OF ROYALTY CLAIMS FILING OF CLAIMS TO ROYALTY FEES COLLECTED UNDER COMPULSORY LICENSE Digital Audio... purposes of royalties filing and fee distribution. Such written authorization, however, will not be... members or affiliates before the Copyright Royalty Board in royalty filing and fee distribution...

  8. Reliability Approach of a Compressor System using Reliability Block ...

    African Journals Online (AJOL)

    pc

    2018-03-05

    Mar 5, 2018 ... This paper presents a reliability analysis of such a system using reliability ... Keywords-compressor system, reliability, reliability block diagram, RBD .... the same structure has been kept with the three subsystems: air flow, oil flow and .... and Safety in Engineering Design", Springer, 2009. [3] P. O'Connor ...

  9. X-Files opjat v stroju

    Index Scriptorium Estoniae

    2008-01-01

    USA sarjale "The X-Files" põhinev teine järjefilm "Salatoimikud: Ma tahan uskuda" ("The X-Files: I Want to Believe") : režissöör Chris Carter : peaosades David Duchovny, Gillian Anderson : Ameerika Ühendriigid - Kanada 2008

  10. The validity and reliability of the diagnosis of hyperkinetic disorders in the Danish Psychiatric Central Research Registry

    DEFF Research Database (Denmark)

    Jensen, Christina Mohr; Vinkel Koch, S; Lauritsen, Marlene Briciet

    2016-01-01

    were used to validate the diagnosis. Patient files were systematically scored for the presence of ICD-10 criteria for HD and oppositional defiant disorder/conduct disorder (ODD/CD; F91). Further to this, an inter-rater reliability study was also conducted, whereby two experienced child and adolescent......OBJECTIVE: To validate the diagnosis of hyperkinetic disorders (HD) in the Danish Psychiatric Central Research Registry (DPCRR) for children and adolescents aged 4 to 15 given in the years 1995 to 2005. METHOD: From a total of 4568 participants, a representative random subsample of n=387 patients...... it was not possible to reach a conclusion for 5.1% of the cases, 3.8% of the diagnoses were registration errors, and in 4.3% of the files the diagnosis had to be rejected. Inter-rater agreement was high (κ=0.83, z=10.9, Pvalidity of hyperkinetic disorders, unspecified (F90.9) was lower and comorbid CD...

  11. Frontiers of reliability

    CERN Document Server

    Basu, Asit P; Basu, Sujit K

    1998-01-01

    This volume presents recent results in reliability theory by leading experts in the world. It will prove valuable for researchers, and users of reliability theory. It consists of refereed invited papers on a broad spectrum of topics in reliability. The subjects covered include Bayesian reliability, Bayesian reliability modeling, confounding in a series system, DF tests, Edgeworth approximation to reliability, estimation under random censoring, fault tree reduction for reliability, inference about changes in hazard rates, information theory and reliability, mixture experiment, mixture of Weibul

  12. Software reliability

    CERN Document Server

    Bendell, A

    1986-01-01

    Software Reliability reviews some fundamental issues of software reliability as well as the techniques, models, and metrics used to predict the reliability of software. Topics covered include fault avoidance, fault removal, and fault tolerance, along with statistical methods for the objective assessment of predictive accuracy. Development cost models and life-cycle cost models are also discussed. This book is divided into eight sections and begins with a chapter on adaptive modeling used to predict software reliability, followed by a discussion on failure rate in software reliability growth mo

  13. 29 CFR 1979.103 - Filing of discrimination complaint.

    Science.gov (United States)

    2010-07-01

    ... subcontractor of an air carrier in violation of the Act may file, or have filed by any person on the employee's... acts and omissions, with pertinent dates, which are believed to constitute the violations. (c) Place of filing. The complaint should be filed with the OSHA Area Director responsible for enforcement activities...

  14. 76 FR 6125 - Combined Notice of Filings #1

    Science.gov (United States)

    2011-02-03

    ... filing per 35: Arthur Kill--Amendment to MBR Tariff 01262011 to be effective 10/8/ 2010. Filed Date: 01... Turbine Power LLC submits tariff filing per 35: Astoria--Amendment to MBR Tariff 01/26/2011 to be... Description: Conemaugh Power LLC submits tariff filing per 35: Conemaugh--Amendment to MBR Tariff 01262011 to...

  15. 77 FR 43820 - Combined Notice of Filings #1

    Science.gov (United States)

    2012-07-26

    .... Docket Numbers: ER12-1946-001. Applicants: Duke Energy Beckjord, LLC. Description: Amendment to MBR...: Amendment to MBR Tariff Filing to be effective 10/1/ 2012. Filed Date: 7/18/12. Accession Number: 20120718... Creek, LLC. Description: Amendment to MBR Tariff Filing to be effective 10/1/ 2012. Filed Date: 7/18/12...

  16. 77 FR 60418 - Combined Notice of Filings

    Science.gov (United States)

    2012-10-03

    ... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission Combined Notice of Filings Take notice that the Commission has received the following Natural Gas Pipeline Rate and Refund Report filings...-1064-000. Applicants: Venice Gathering System, L.L.C. Description: NAESB 2.0 Compliance Filing to be...

  17. An exploratory discussion on business files compilation

    International Nuclear Information System (INIS)

    Gao Chunying

    2014-01-01

    Business files compilation for an enterprise is a distillation and recreation of its spiritual wealth, from which the applicable information can be available to those who want to use it in a fast, extensive and precise way. Proceeding from the effects of business files compilation on scientific researches, productive constructions and developments, this paper in five points discusses the way how to define topics, analyze historical materials, search or select data and process it to an enterprise archives collection. Firstly, to expound the importance and necessity of business files compilation in production, operation and development of an company; secondly, to present processing methods from topic definition, material searching and data selection to final examination and correction; thirdly, to define principle and classification in order to make different categories and levels of processing methods available to business files compilation; fourthly, to discuss the specific method how to implement a file compilation through a documentation collection upon principle of topic definition gearing with demand; fifthly, to address application of information technology to business files compilation in view point of widely needs for business files so as to level up enterprise archives management. The present discussion focuses on the examination and correction principle of enterprise historical material compilation and the basic classifications as well as the major forms of business files compilation achievements. (author)

  18. Traffic Responsive Control of Intersections with Predicted Arrival Times: A Markovian Approach

    NARCIS (Netherlands)

    Haijema, R.; Hendrix, E.M.T.

    2014-01-01

    The dynamic adaptive control of traffic lights can be formulated as a Markov decision problem (MDP). This framework is hardly used, as solving an MDP can be very time-consuming and is only possible for simple infrastructures with a small number of traffic flows. Nevertheless, we show that the MDP

  19. System Reliability Engineering

    International Nuclear Information System (INIS)

    Lim, Tae Jin

    2005-02-01

    This book tells of reliability engineering, which includes quality and reliability, reliability data, importance of reliability engineering, reliability and measure, the poisson process like goodness of fit test and the poisson arrival model, reliability estimation like exponential distribution, reliability of systems, availability, preventive maintenance such as replacement policies, minimal repair policy, shock models, spares, group maintenance and periodic inspection, analysis of common cause failure, and analysis model of repair effect.

  20. 75 FR 62371 - Combined Notice of Filings #2

    Science.gov (United States)

    2010-10-08

    .... Description: Weyerhaeuser NR Company submits tariff filing per 35.12: Weyerhaeuser NR Company MBR Tariff to be..., Inc. MBR eTariff Filing to be effective 9/30/2010. Filed Date: 09/30/2010. Accession Number: 20100930... 35.12: Chandler Wind Partners, LLC MBR Tariff to be effective 9/30/ 2010. Filed Date: 09/30/2010...

  1. Collective operations in a file system based execution model

    Science.gov (United States)

    Shinde, Pravin; Van Hensbergen, Eric

    2013-02-19

    A mechanism is provided for group communications using a MULTI-PIPE synthetic file system. A master application creates a multi-pipe synthetic file in the MULTI-PIPE synthetic file system, the master application indicating a multi-pipe operation to be performed. The master application then writes a header-control block of the multi-pipe synthetic file specifying at least one of a multi-pipe synthetic file system name, a message type, a message size, a specific destination, or a specification of the multi-pipe operation. Any other application participating in the group communications then opens the same multi-pipe synthetic file. A MULTI-PIPE file system module then implements the multi-pipe operation as identified by the master application. The master application and the other applications then either read or write operation messages to the multi-pipe synthetic file and the MULTI-PIPE synthetic file system module performs appropriate actions.

  2. Search the SEC website for the latest EDGAR filings

    Data.gov (United States)

    Securities and Exchange Commission — This listing contains the most recent filings for the current official filing date (including filings made after the 5:30pm deadline on the previous filing day)....

  3. 77 FR 27221 - Combined Notice of Filings

    Science.gov (United States)

    2012-05-09

    ... Generator Status of Minonk Wind, LLC. Filed Date: 4/19/12. Accession Number: 20120419-5196. Comments Due: 5... Self-Certification of Exempt Wholesale Generator Status of Senate Wind, LLC. Filed Date: 4/19/12... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission Combined Notice of Filings Take notice...

  4. 21 CFR 720.2 - Times for filing.

    Science.gov (United States)

    2010-04-01

    ... Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) COSMETICS VOLUNTARY FILING OF COSMETIC PRODUCT INGREDIENT COMPOSITION STATEMENTS § 720.2 Times for filing. Within 180 days after forms are made available to the industry, Form FDA 2512 should be filed for each cosmetic...

  5. 75 FR 51451 - Erie Boulevard Hydropower, L.P.; Notice of Intent To File License Application, Filing of Pre...

    Science.gov (United States)

    2010-08-20

    ... Hydropower, L.P.; Notice of Intent To File License Application, Filing of Pre-Application Document, and.... Project No.: 7320-040. c. Dated Filed: June 29, 2010. d. Submitted By: Erie Boulevard Hydropower, L.P. e...: John Mudre at (202) 502-8902; or e-mail at [email protected] . j. Erie Boulevard Hydropower, L.P...

  6. Flexibility and Performance of Parallel File Systems

    Science.gov (United States)

    Kotz, David; Nieuwejaar, Nils

    1996-01-01

    As we gain experience with parallel file systems, it becomes increasingly clear that a single solution does not suit all applications. For example, it appears to be impossible to find a single appropriate interface, caching policy, file structure, or disk-management strategy. Furthermore, the proliferation of file-system interfaces and abstractions make applications difficult to port. We propose that the traditional functionality of parallel file systems be separated into two components: a fixed core that is standard on all platforms, encapsulating only primitive abstractions and interfaces, and a set of high-level libraries to provide a variety of abstractions and application-programmer interfaces (API's). We present our current and next-generation file systems as examples of this structure. Their features, such as a three-dimensional file structure, strided read and write interfaces, and I/O-node programs, are specifically designed with the flexibility and performance necessary to support a wide range of applications.

  7. Evaluated nuclear data file of Th-232

    International Nuclear Information System (INIS)

    Meadows, J.; Poenitz, W.; Smith, A.; Smith, D.; Whalen, J.; Howerton, R.

    1977-09-01

    An evaluated nuclear data file for thorium is described. The file extends over the energy range 0.049 (i.e., the inelastic-scattering threshold) to 20.0 MeV and is formulated within the framework of the ENDF system. The input data base, the evaluation procedures and judgments, and ancillary experiments carried out in conjunction with the evaluation are outlined. The file includes: neutron total cross sections, neutron scattering processes, neutron radiative capture cross sections, fission cross sections, (n;2n) and (n;3n) processes, fission properties (e.g., nu-bar and delayed neutron emission) and photon production processes. Regions of uncertainty are pointed out particularly where new measured results would be of value. The file is extended to thermal energies using previously reported resonance evaluations thereby providing a complete file for neutronic calculations. Integral data tests indicated that the file was suitable for neutronic calculations in the MeV range

  8. 78 FR 20901 - Combined Notice of Filings #1

    Science.gov (United States)

    2013-04-08

    ... Marketing Inc. submits Category Seller Clarification to be effective 3/29/2013. Filed Date: 3/29/13... submits Cost- Based Tariffs Compliance Filing to be effective 4/1/2013. Filed Date: 3/29/13. Accession... to be effective N/A. Filed Date: 3/29/13. Accession Number: 20130329-5223. Comments Due: 5 p.m. ET 4...

  9. 29 CFR 24.103 - Filing of retaliation complaint.

    Science.gov (United States)

    2010-07-01

    ... violations. (c) Place of Filing. The complaint should be filed with the OSHA Area Director responsible for... by an employer in violation of any of the statutes listed in § 24.100(a) may file, or have filed by... with any OSHA officer or employee. Addresses and telephone numbers for these officials are set forth in...

  10. 76 FR 16404 - Combined Notice of Filings #1

    Science.gov (United States)

    2011-03-23

    ...: Amendment to MBR Tariff to be effective 5/13/2011. Filed Date: 03/14/2011. Accession Number: 20110314-5272... tariff filing per 35: Amendment to MBR Tariff to be effective 5/13/ 2011. Filed Date: 03/14/2011.... Subsidiary No. 2, Inc. submits tariff filing per 35: Amendment to MBR Tariff to be effective 5/13/ 2011...

  11. 77 FR 33206 - Combined Notice of Filings #2

    Science.gov (United States)

    2012-06-05

    ... tariff filing per 35: High Trail Wind Farm First Revised MBR to be effective 5/26/2012. Filed Date: 5/25... per 35: Old Trail Wind Farm First Revised MBR to be effective 5/26/2012. Filed Date: 5/25/12... First Revised MBR to be effective 6/1/2012. Filed Date: 5/25/12. Accession Number: 20120525-5088...

  12. A reliability simulation language for reliability analysis

    International Nuclear Information System (INIS)

    Deans, N.D.; Miller, A.J.; Mann, D.P.

    1986-01-01

    The results of work being undertaken to develop a Reliability Description Language (RDL) which will enable reliability analysts to describe complex reliability problems in a simple, clear and unambiguous way are described. Component and system features can be stated in a formal manner and subsequently used, along with control statements to form a structured program. The program can be compiled and executed on a general-purpose computer or special-purpose simulator. (DG)

  13. A study of operational and testing reliability in software reliability analysis

    International Nuclear Information System (INIS)

    Yang, B.; Xie, M.

    2000-01-01

    Software reliability is an important aspect of any complex equipment today. Software reliability is usually estimated based on reliability models such as nonhomogeneous Poisson process (NHPP) models. Software systems are improving in testing phase, while it normally does not change in operational phase. Depending on whether the reliability is to be predicted for testing phase or operation phase, different measure should be used. In this paper, two different reliability concepts, namely, the operational reliability and the testing reliability, are clarified and studied in detail. These concepts have been mixed up or even misused in some existing literature. Using different reliability concept will lead to different reliability values obtained and it will further lead to different reliability-based decisions made. The difference of the estimated reliabilities is studied and the effect on the optimal release time is investigated

  14. Human reliability

    International Nuclear Information System (INIS)

    Embrey, D.E.

    1987-01-01

    Concepts and techniques of human reliability have been developed and are used mostly in probabilistic risk assessment. For this, the major application of human reliability assessment has been to identify the human errors which have a significant effect on the overall safety of the system and to quantify the probability of their occurrence. Some of the major issues within human reliability studies are reviewed and it is shown how these are applied to the assessment of human failures in systems. This is done under the following headings; models of human performance used in human reliability assessment, the nature of human error, classification of errors in man-machine systems, practical aspects, human reliability modelling in complex situations, quantification and examination of human reliability, judgement based approaches, holistic techniques and decision analytic approaches. (UK)

  15. Technetium-99 conjugated with methylene diphosphonate ameliorates ovariectomy-induced osteoporotic phenotype without causing osteonecrosis in the jaw.

    Science.gov (United States)

    Zhao, Yinghua; Wang, Lei; Liu, Yi; Akiyama, Kentaro; Chen, Chider; Atsuta, Ikiru; Zhou, Tao; Duan, Xiaohong; Jin, Yan; Shi, Songtao

    2012-12-01

    Technetium-99 conjugated with methylene diphosphonate ((99)Tc-MDP) is a novel bisphosphonate derivative without radioactivity and has been successfully used to treat arthritis in China for years. Since bisphosphonate therapy has the potential to induce bisphosphonate-related osteonecrosis of the jaw (BRONJ), we examined whether (99)Tc-MDP represents a new class of bisphosphonate for antiresorptive therapy to ameliorate estrogen deficiency-induced bone resorption with less risk of causing BRONJ. We showed that (99)Tc-MDP-treated, ovariectomized (OVX) mice had significantly improved bone mineral density and trabecular bone volume in comparison to the untreated OVX group by inhibiting osteoclasts and enhancing osteogenic differentiation of bone marrow mesenchymal stem cells. To determine the potential of inducing BRONJ, (99)Tc-MDP/dexamethasone (Dex) or zoledronate/Dex was administered into C57BL/6J mice via the tail vein, followed by extraction of maxillary first molars. Interestingly, (99)Tc-MDP treatment showed less risk to induce osteonecrosis in the maxillary bones compared to zoledronate treatment group, partially because (99)Tc-MDP neither suppressed adaptive regulatory T cells nor activated the inflammatory T-helper-producing interleukin-17 cells. Taken together, our findings demonstrate that (99)Tc-MDP therapy may be a promising approach in the treatment of osteoporosis with less risk of causing BRONJ.

  16. Index files for Belle II - very small skim containers

    Science.gov (United States)

    Sevior, Martin; Bloomfield, Tristan; Kuhr, Thomas; Ueda, I.; Miyake, H.; Hara, T.

    2017-10-01

    The Belle II experiment[1] employs the root file format[2] for recording data and is investigating the use of “index-files” to reduce the size of data skims. These files contain pointers to the location of interesting events within the total Belle II data set and reduce the size of data skims by 2 orders of magnitude. We implement this scheme on the Belle II grid by recording the parent file metadata and the event location within the parent file. While the scheme works, it is substantially slower than a normal sequential read of standard skim files using default root file parameters. We investigate the performance of the scheme by adjusting the “splitLevel” and “autoflushsize” parameters of the root files in the parent data files.

  17. 77 FR 23474 - Combined Notice of Filings

    Science.gov (United States)

    2012-04-19

    ...: Young Gas Storage Company, Ltd. Description: EBB Notice Categories to be effective 5/15/2012. Filed Date... intervention is necessary to become a party to the proceeding. Filings in Existing Proceedings Docket Numbers... requirements, interventions, protests, and service can be found at: http://www.ferc.gov/docs-filing/efiling...

  18. DMFS: A Data Migration File System for NetBSD

    Science.gov (United States)

    Studenmund, William

    2000-01-01

    I have recently developed DMFS, a Data Migration File System, for NetBSD. This file system provides kernel support for the data migration system being developed by my research group at NASA/Ames. The file system utilizes an underlying file store to provide the file backing, and coordinates user and system access to the files. It stores its internal metadata in a flat file, which resides on a separate file system. This paper will first describe our data migration system to provide a context for DMFS, then it will describe DMFS. It also will describe the changes to NetBSD needed to make DMFS work. Then it will give an overview of the file archival and restoration procedures, and describe how some typical user actions are modified by DMFS. Lastly, the paper will present simple performance measurements which indicate that there is little performance loss due to the use of the DMFS layer.

  19. 831 Files

    Data.gov (United States)

    Social Security Administration — SSA-831 file is a collection of initial and reconsideration adjudicative level DDS disability determinations. (A few hearing level cases are also present, but the...

  20. 47 CFR 1.1704 - Station files.

    Science.gov (United States)

    2010-10-01

    ... System (COALS) § 1.1704 Station files. Applications, notifications, correspondence, electronic filings... Television Relay Service (CARS) are maintained by the Commission in COALS and the Public Reference Room...

  1. 78 FR 70029 - Combined Notice of Filings #1

    Science.gov (United States)

    2013-11-22

    ..., Ameren Energy Marketing Company, AmerenEnergy Resources Generating Company, AmerenEnergy Medina Valley... filing per 35: Integrated Marketplace Second Compliance Filing to be effective 3/ 1/2014. Filed Date: 11...

  2. Design and creation of a direct access nuclear data file

    International Nuclear Information System (INIS)

    Charpentier, P.

    1981-06-01

    General considerations on the structure of instructions and files are reviewed. Design, organization and mode of use of the different files: instruction file, index files, inverted files, automatic analysis and inquiry programs are examined [fr

  3. 37 CFR 11.41 - Filing of papers.

    Science.gov (United States)

    2010-07-01

    ... 37 Patents, Trademarks, and Copyrights 1 2010-07-01 2010-07-01 false Filing of papers. 11.41... Disciplinary Proceedings; Jurisdiction, Sanctions, Investigations, and Proceedings § 11.41 Filing of papers. (a... papers filed after the complaint and prior to entry of an initial decision by the hearing officer shall...

  4. 78 FR 13050 - Combined Notice of Filings

    Science.gov (United States)

    2013-02-26

    ... be considered, but intervention is necessary to become a party to the proceeding. Filings in Existing Proceedings Docket Numbers: RP13-106-002. Applicants: Young Gas Storage Company, Ltd. Description: Young NAESB..., protests, and service can be found at: http://www.ferc.gov/docs-filing/efiling/filing-req.pdf . For other...

  5. Software for Managing Personal Files.

    Science.gov (United States)

    Lundeen, Gerald

    1989-01-01

    Discusses the special characteristics of personal file management software and compares four microcomputer software packages: Notebook II with Bibliography and Convert, Pro-Cite with Biblio-Links, askSam, and Reference Manager. Each package is evaluated in terms of the user interface, file maintenance, retrieval capabilities, output, and…

  6. Reliability Calculations

    DEFF Research Database (Denmark)

    Petersen, Kurt Erling

    1986-01-01

    Risk and reliability analysis is increasingly being used in evaluations of plant safety and plant reliability. The analysis can be performed either during the design process or during the operation time, with the purpose to improve the safety or the reliability. Due to plant complexity and safety...... and availability requirements, sophisticated tools, which are flexible and efficient, are needed. Such tools have been developed in the last 20 years and they have to be continuously refined to meet the growing requirements. Two different areas of application were analysed. In structural reliability probabilistic...... approaches have been introduced in some cases for the calculation of the reliability of structures or components. A new computer program has been developed based upon numerical integration in several variables. In systems reliability Monte Carlo simulation programs are used especially in analysis of very...

  7. 75 FR 62522 - Combined Notice of Filings No. 3

    Science.gov (United States)

    2010-10-12

    ... filing per 154.203: NAESB EDI Form Filing to be effective 11/1/ 2010. Filed Date: 09/30/2010. Accession....9 EDI Form to be effective 11/1/2010. Filed Date: 09/30/2010. Accession Number: 20100930-5348...

  8. MR-AFS: a global hierarchical file-system

    International Nuclear Information System (INIS)

    Reuter, H.

    2000-01-01

    The next generation of fusion experiments will use object-oriented technology creating the need for world wide sharing of an underlying hierarchical file-system. The Andrew file system (AFS) is a well known and widely spread global distributed file-system. Multiple-resident-AFS (MR-AFS) combines the features of AFS with hierarchical storage management systems. Files in MR-AFS therefore may be migrated on secondary storage, such as roboted tape libraries. MR-AFS is in use at IPP for the current experiments and data originating from super-computer applications. Experiences and scalability issues are discussed

  9. Tc-99m-methylene-diphosphonate mammo- and bone- scintigraphy in preoperative staging of breast carcinoma

    International Nuclear Information System (INIS)

    Piperkova, E.; Gavrilov, I.; Garanina, Z.; Alexandrova, E.; Dimitrova, M.; Katerinski, K.

    2003-01-01

    Objective: The study is aimed to assess the potentialities of 99m Tc-MDP for visualization of the breast cancer during the routine preoperative bone scintigraphy in high-risk women. Material and methods: The scintimammography with 99m Tc-MDP has been carried out in 82 women, age between 30 and 74, during the preoperative bone scintigraphy, 62 of them before surgery or neoadjuvant chemotherapy for the breast cancer, an 12 - with hyperdense or undergone an operation of the mammary gland and suspected for breast cancer on the base of the mammography and/or ultrasonography. All results have been verified histologically. The scintimammography has been performed from 5 to 15 minutes after the i.v. injection of 740 MBq 99m Tc-MDP. Results: The build up of 99m Tc-MDP in the breast parenchyma has being changed in the course of time. On the early images 71 verified tumor lesions have been visualized with a hyper fixation of 99m Tc-MDP in the breast and non-homogenous buildup above the background in fibrocystic processes. In 12 patients, hyper fixated regional lymph nodes have been visualized, which have been verified later as metastases N1-2. Cancer has been verified in 3 patient suspected for breast cancer and hyper fixation of 99m Tc-MDP. All verified lesions are G2-3 with an active neoangiogenesis. In 7 women with fibrocystic mastopathy, the 99m Tc-MDP hyper fixation remains at the late stages at different decreasing rate. The neoplastic lesions show faster 'washout'. Conclusions: The 99m Tc-MDP scintigraphy allows to localize successfully primary and regional lesions in the breast and lymph nodes with high sensitivity (97%) and PPV up to 100%. It is economically justified to expand the bone scintigraphy with 99m Tc-MDP by an early scanning for the complete breast cancer staging

  10. 29 CFR 801.71 - Filing and service.

    Science.gov (United States)

    2010-07-01

    ... 29 Labor 3 2010-07-01 2010-07-01 false Filing and service. 801.71 Section 801.71 Labor Regulations Relating to Labor (Continued) WAGE AND HOUR DIVISION, DEPARTMENT OF LABOR OTHER LAWS APPLICATION OF THE... and Order of Administrative Law Judge § 801.71 Filing and service. (a) Filing. All documents submitted...

  11. An analysis of file system and installation of the file management system for NOS operating system

    International Nuclear Information System (INIS)

    Lee, Young Jai; Park, Sun Hee; Hwang, In Ah; Kim, Hee Kyung

    1992-06-01

    In this technical report, we analyze NOS file structure for Cyber 170-875 and Cyber 960-31 computer system. We also describe functions, procedure and how-to-operate and how-to-use of VDS. VDS is used to manage large files effectively for Cyber computer system. The purpose of the VDS installation is to increase the virtual disk storage by utilizing magnetic tape, to assist the users of the computer system in managing their files, and to enhance the performance of KAERI Cyber computer system. (Author)

  12. Collection and treatment of reliability data for nuclear plants

    International Nuclear Information System (INIS)

    McHugh, B.

    1973-09-01

    This paper describes some of the results achieved with the Argus data bank at the Institution of Thermal Power Engineering at the Chalmers University of Technology. This data bank, or rather data collection system, has been established to cover nuclear activities the world over. The system comprises in essence a number of data files. The prime files are those containing the basic data on the various plants - plant size and type, country and NSSS supplier and an indication of plantstatus. Further files contain plant design data and parameters and all available information on construction as commissioning timetables. To cover the operation of plant two files have been established. One file, which is updated on a monthly basis, contains power production statistics. The other file contains failure data. In this file are recorded the time and duration of plant shutdown together with the primary reason (s) for this. (M.S.)

  13. Biodistribution of 99Mo in rats

    International Nuclear Information System (INIS)

    Souza, Raphael Sancho Sisley de; Ribeiro, Bianca da Silva; Dantas, Ana Leticia Almeida; Dantas, Bernardo Maranhao; Bernardo Filho, Mario

    2009-01-01

    The modification of 99 Mo standard metabolism in the presence of MDP would alter the dosimetry of this radionuclide in nuclear medicine patients. Therefore, the objective of this work is to evaluate the influence of MDP in the biodistribution of 99 Mo. Wistar rats were divided in two groups of six animals, being inoculated respectively 99 Molibdate and 99 Mo+MDP via plex ocular. The biodistribution study was carried out after 10 and 120 minutes respectively. The organs were counted with a NaI(Tl) detector. The uptake values did not present significant differences among the groups. An in vitro study through planar chromatography was carried out to determine the affinity between molybdenum and MDP. The results show that 99 Mo has low affinity both to propanone and NaCl-0.9% solution. However, 99 Mo in the presence of MDP presented affinity to NaCl-0.9% solution and low affinity to propanone suggesting that 99 Mo was bound to MDP under the conditions of the experiment. (author)

  14. Reliability in the utility computing era: Towards reliable Fog computing

    DEFF Research Database (Denmark)

    Madsen, Henrik; Burtschy, Bernard; Albeanu, G.

    2013-01-01

    This paper considers current paradigms in computing and outlines the most important aspects concerning their reliability. The Fog computing paradigm as a non-trivial extension of the Cloud is considered and the reliability of the networks of smart devices are discussed. Combining the reliability...... requirements of grid and cloud paradigms with the reliability requirements of networks of sensor and actuators it follows that designing a reliable Fog computing platform is feasible....

  15. 77 FR 23708 - Combined Notice of Filings #2

    Science.gov (United States)

    2012-04-20

    ... submits tariff filing per 35.13(a)(2)(iii: 11--20120413 I&M Oper Co MBR Conc to be effective 1/1/2012... filing per 35.13(a)(2)(iii: 12--20120413 KPCo Oper Co MBR Conc to be effective 1/ 1/2012. Filed Date: 4... OPCo Oper Co MBR Conc to be effective 1/ 1/2012. Filed Date: 4/13/12. Accession Number: 20120413-5179...

  16. Dependent systems reliability estimation by structural reliability approach

    DEFF Research Database (Denmark)

    Kostandyan, Erik; Sørensen, John Dalsgaard

    2014-01-01

    Estimation of system reliability by classical system reliability methods generally assumes that the components are statistically independent, thus limiting its applicability in many practical situations. A method is proposed for estimation of the system reliability with dependent components, where...... the leading failure mechanism(s) is described by physics of failure model(s). The proposed method is based on structural reliability techniques and accounts for both statistical and failure effect correlations. It is assumed that failure of any component is due to increasing damage (fatigue phenomena...... identification. Application of the proposed method can be found in many real world systems....

  17. Grammar-Based Specification and Parsing of Binary File Formats

    Directory of Open Access Journals (Sweden)

    William Underwood

    2012-03-01

    Full Text Available The capability to validate and view or play binary file formats, as well as to convert binary file formats to standard or current file formats, is critically important to the preservation of digital data and records. This paper describes the extension of context-free grammars from strings to binary files. Binary files are arrays of data types, such as long and short integers, floating-point numbers and pointers, as well as characters. The concept of an attribute grammar is extended to these context-free array grammars. This attribute grammar has been used to define a number of chunk-based and directory-based binary file formats. A parser generator has been used with some of these grammars to generate syntax checkers (recognizers for validating binary file formats. Among the potential benefits of an attribute grammar-based approach to specification and parsing of binary file formats is that attribute grammars not only support format validation, but support generation of error messages during validation of format, validation of semantic constraints, attribute value extraction (characterization, generation of viewers or players for file formats, and conversion to current or standard file formats. The significance of these results is that with these extensions to core computer science concepts, traditional parser/compiler technologies can potentially be used as a part of a general, cost effective curation strategy for binary file formats.

  18. 75 FR 49918 - Combined Notice of Filings # 1

    Science.gov (United States)

    2010-08-16

    ... Missouri Operations Company submits tariff filing per 35: KCP&L-GMO Baseline Compliance Filing to be.... Description: KCP&L Greater Missouri Operations Company submits tariff filing per 35.12: KCP&L-GMO OATT Volume...

  19. Adding Data Management Services to Parallel File Systems

    Energy Technology Data Exchange (ETDEWEB)

    Brandt, Scott [Univ. of California, Santa Cruz, CA (United States)

    2015-03-04

    The objective of this project, called DAMASC for “Data Management in Scientific Computing”, is to coalesce data management with parallel file system management to present a declarative interface to scientists for managing, querying, and analyzing extremely large data sets efficiently and predictably. Managing extremely large data sets is a key challenge of exascale computing. The overhead, energy, and cost of moving massive volumes of data demand designs where computation is close to storage. In current architectures, compute/analysis clusters access data in a physically separate parallel file system and largely leave it scientist to reduce data movement. Over the past decades the high-end computing community has adopted middleware with multiple layers of abstractions and specialized file formats such as NetCDF-4 and HDF5. These abstractions provide a limited set of high-level data processing functions, but have inherent functionality and performance limitations: middleware that provides access to the highly structured contents of scientific data files stored in the (unstructured) file systems can only optimize to the extent that file system interfaces permit; the highly structured formats of these files often impedes native file system performance optimizations. We are developing Damasc, an enhanced high-performance file system with native rich data management services. Damasc will enable efficient queries and updates over files stored in their native byte-stream format while retaining the inherent performance of file system data storage via declarative queries and updates over views of underlying files. Damasc has four key benefits for the development of data-intensive scientific code: (1) applications can use important data-management services, such as declarative queries, views, and provenance tracking, that are currently available only within database systems; (2) the use of these services becomes easier, as they are provided within a familiar file

  20. Dynamic Non-Hierarchical File Systems for Exascale Storage

    Energy Technology Data Exchange (ETDEWEB)

    Long, Darrell E. [Univ. of California, Santa Cruz, CA (United States); Miller, Ethan L [Univ. of California, Santa Cruz, CA (United States)

    2015-02-24

    This constitutes the final report for “Dynamic Non-Hierarchical File Systems for Exascale Storage”. The ultimate goal of this project was to improve data management in scientific computing and high-end computing (HEC) applications, and to achieve this goal we proposed: to develop the first, HEC-targeted, file system featuring rich metadata and provenance collection, extreme scalability, and future storage hardware integration as core design goals, and to evaluate and develop a flexible non-hierarchical file system interface suitable for providing more powerful and intuitive data management interfaces to HEC and scientific computing users. Data management is swiftly becoming a serious problem in the scientific community – while copious amounts of data are good for obtaining results, finding the right data is often daunting and sometimes impossible. Scientists participating in a Department of Energy workshop noted that most of their time was spent “...finding, processing, organizing, and moving data and it’s going to get much worse”. Scientists should not be forced to become data mining experts in order to retrieve the data they want, nor should they be expected to remember the naming convention they used several years ago for a set of experiments they now wish to revisit. Ideally, locating the data you need would be as easy as browsing the web. Unfortunately, existing data management approaches are usually based on hierarchical naming, a 40 year-old technology designed to manage thousands of files, not exabytes of data. Today’s systems do not take advantage of the rich array of metadata that current high-end computing (HEC) file systems can gather, including content-based metadata and provenance1 information. As a result, current metadata search approaches are typically ad hoc and often work by providing a parallel management system to the “main” file system, as is done in Linux (the locate utility), personal computers, and enterprise search

  1. 77 FR 23241 - Lock+ Hydro Friends Fund XXX, LLC; Notice of Intent To File License Application, Filing of Pre...

    Science.gov (United States)

    2012-04-18

    ... Friends Fund XXX, LLC; Notice of Intent To File License Application, Filing of Pre-Application Document.... Date Filed: February 20, 2012. d. Submitted By: Lock+ Hydro Friends Fund XXX, LLC. e. Name of Project... Applicant Contact: Mr. Mark R. Stover, Lock+\\TM\\ Hydro Friends Fund XXX, c/o Hydro Green Energy, LLC, 900...

  2. Analyzing endosonic root canal file oscillations: an in vitro evaluation.

    Science.gov (United States)

    Lea, Simon C; Walmsley, A Damien; Lumley, Philip J

    2010-05-01

    Passive ultrasonic irrigation may be used to improve bacterial reduction within the root canal. The technique relies on a small file being driven to oscillate freely within the canal and activating an irrigant solution through biophysical forces such as microstreaming. There is limited information regarding a file's oscillation patterns when operated while surrounded by fluid as is the case within a canal root. Files of different sizes (#10 and #30, 27 mm and 31 mm) were connected to an ultrasound generator via a 120 degrees file holder. Files were immersed in a water bath, and a laser vibrometer set up with measurement lines superimposed over the files. The laser vibrometer was scanned over the oscillating files. Measurements were repeated 10 times for each file/power setting used. File mode shapes are comprised of a series of nodes/antinodes, with thinner, longer files producing more antinodes. The maximum vibration occurred at the free end of the file. Increasing generator power had no significant effect on this maximum amplitude (p > 0.20). Maximum displacement amplitudes were 17 to 22 microm (#10 file, 27 mm), 15 to 21 microm (#10 file, 31 mm), 6 to 9 microm (#30 file, 27 mm), and 5 to 7 microm (#30, 31 mm) for all power settings. Antinodes occurring along the remaining file length were significantly larger at generator power 1 than at powers 2 through 5 (p generator powers, energy delivered to the file is dissipated in unwanted vibration resulting in reduced vibration displacement amplitudes. This may reduce the occurrence of the biophysical forces necessary to maximize the technique's effectiveness. Copyright (c) 2010 American Association of Endodontists. Published by Elsevier Inc. All rights reserved.

  3. Improving File System Performance by Striping

    Science.gov (United States)

    Lam, Terance L.; Kutler, Paul (Technical Monitor)

    1998-01-01

    This document discusses the performance and advantages of striped file systems on the SGI AD workstations. Performance of several striped file system configurations are compared and guidelines for optimal striping are recommended.

  4. 78 FR 32383 - Combined Notice of Filings #1

    Science.gov (United States)

    2013-05-30

    .... Description: Inquiry Response to be effective 5/12/2013. Filed Date: 5/21/13. Accession Number: 20130521-5167....ferc.gov/docs-filing/efiling/filing-req.pdf . For other information, call (866) 208-3676 (toll free...

  5. 8 CFR 236.14 - Filing.

    Science.gov (United States)

    2010-01-01

    ... 8 Aliens and Nationality 1 2010-01-01 2010-01-01 false Filing. 236.14 Section 236.14 Aliens and Nationality DEPARTMENT OF HOMELAND SECURITY IMMIGRATION REGULATIONS APPREHENSION AND DETENTION OF INADMISSIBLE... initial denial, to allow the alien the opportunity to file a new Form I-817 application in order to...

  6. Analyzing the reliability of shuffle-exchange networks using reliability block diagrams

    International Nuclear Information System (INIS)

    Bistouni, Fathollah; Jahanshahi, Mohsen

    2014-01-01

    Supercomputers and multi-processor systems are comprised of thousands of processors that need to communicate in an efficient way. One reasonable solution would be the utilization of multistage interconnection networks (MINs), where the challenge is to analyze the reliability of such networks. One of the methods to increase the reliability and fault-tolerance of the MINs is use of various switching stages. Therefore, recently, the reliability of one of the most common MINs namely shuffle-exchange network (SEN) has been evaluated through the investigation on the impact of increasing the number of switching stage. Also, it is concluded that the reliability of SEN with one additional stage (SEN+) is better than SEN or SEN with two additional stages (SEN+2), even so, the reliability of SEN is better compared to SEN with two additional stages (SEN+2). Here we re-evaluate the reliability of these networks where the results of the terminal, broadcast, and network reliability analysis demonstrate that SEN+ and SEN+2 continuously outperform SEN and are very alike in terms of reliability. - Highlights: • The impact of increasing the number of stages on reliability of MINs is investigated. • The RBD method as an accurate method is used for the reliability analysis of MINs. • Complex series–parallel RBDs are used to determine the reliability of the MINs. • All measures of the reliability (i.e. terminal, broadcast, and network reliability) are analyzed. • All reliability equations will be calculated for different size N×N

  7. 76 FR 80921 - Combined Notice of Filings

    Science.gov (United States)

    2011-12-27

    .... Comments Due: 5 p.m. ET 12/27/11. Docket Numbers: RP12-243-000. Applicants: Young Gas Storage Company, Ltd... considered, but intervention is necessary to become a party to the proceeding. The filings are accessible in... can be found at: http://www.ferc.gov/docs-filing/efiling/filing-req.pdf . For other information, call...

  8. 21 CFR 314.420 - Drug master files.

    Science.gov (United States)

    2010-04-01

    ... the context of an application under part 312 or this part. A drug master file may contain information... incorporate by reference all or part of the contents of any drug master file in support of the submission if... information in a drug master file (except the list required under paragraph (d) of this section) is required...

  9. Chronic Condition Public Use File (PUF)

    Data.gov (United States)

    U.S. Department of Health & Human Services — This release contains the Chronic Conditions Public Use Files (PUF) with information from Medicare claims. The CMS Chronic Conditions PUF is an aggregated file in...

  10. Analyzing Log Files using Data-Mining

    Directory of Open Access Journals (Sweden)

    Marius Mihut

    2008-01-01

    Full Text Available Information systems (i.e. servers, applications and communication devices create a large amount of monitoring data that are saved as log files. For analyzing them, a data-mining approach is helpful. This article presents the steps which are necessary for creating an ‘analyzing instrument’, based on an open source software called Waikato Environment for Knowledge Analysis (Weka [1]. For exemplification, a system log file created by a Windows-based operating system, is used as input file.

  11. 77 FR 3758 - Combined Notice of Filings #1

    Science.gov (United States)

    2012-01-25

    ...: Attachment H Schedule 7 Compliance Filing to be effective 6/1/2011. Filed Date: 1/13/12. Accession Number... filings: Docket Numbers: QF12-159-000. Applicants: City of Kinston, NC. Description: FERC Form 556 of City...

  12. EPA FRS Facilities State Single File CSV Download

    Science.gov (United States)

    This page provides state comma separated value (CSV) files containing key information of all facilities and sites within the Facility Registry System (FRS). Each state zip file contains a single CSV file of key facility-level information.

  13. 77 FR 12830 - Pershing County Water Conservation District; Notice of Intent To File License Application, Filing...

    Science.gov (United States)

    2012-03-02

    ... Water Conservation District; Notice of Intent To File License Application, Filing of Pre-Application.... Submitted by: Pershing County Water Conservation District (Pershing County). e. Name of Project: Humboldt... the Commission's regulations. h. Potential Applicant Contact: Bennie Hodges, Pershing County Water...

  14. Ambulance Reasonable Charge Public Use Files

    Data.gov (United States)

    U.S. Department of Health & Human Services — The Ambulance Reasonable Charge public use files for calendar years (CY) 2003 through 2005 are located in the Downloads section below. These public use files are...

  15. Portable File Format (PFF) specifications

    Energy Technology Data Exchange (ETDEWEB)

    Dolan, Daniel H. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)

    2015-02-01

    Created at Sandia National Laboratories, the Portable File Format (PFF) allows binary data transfer across computer platforms. Although this capability is supported by many other formats, PFF files are still in use at Sandia, particularly in pulsed power research. This report provides detailed PFF specifications for accessing data without relying on legacy code.

  16. ACONC Files

    Data.gov (United States)

    U.S. Environmental Protection Agency — ACONC files containing simulated ozone and PM2.5 fields that were used to create the model difference plots shown in the journal article. This dataset is associated...

  17. Dynamic Request Routing for Online Video-on-Demand Service: A Markov Decision Process Approach

    Directory of Open Access Journals (Sweden)

    Jianxiong Wan

    2014-01-01

    Full Text Available We investigate the request routing problem in the CDN-based Video-on-Demand system. We model the system as a controlled queueing system including a dispatcher and several edge servers. The system is formulated as a Markov decision process (MDP. Since the MDP formulation suffers from the so-called “the curse of dimensionality” problem, we then develop a greedy heuristic algorithm, which is simple and can be implemented online, to approximately solve the MDP model. However, we do not know how far it deviates from the optimal solution. To address this problem, we further aggregate the state space of the original MDP model and use the bounded-parameter MDP (BMDP to reformulate the system. This allows us to obtain a suboptimal solution with a known performance bound. The effectiveness of two approaches is evaluated in a simulation study.

  18. Reliability data banks

    International Nuclear Information System (INIS)

    Cannon, A.G.; Bendell, A.

    1991-01-01

    Following an introductory chapter on Reliability, what is it, why it is needed, how it is achieved and measured, the principles of reliability data bases and analysis methodologies are the subject of the next two chapters. Achievements due to the development of data banks are mentioned for different industries in the next chapter, FACTS, a comprehensive information system for industrial safety and reliability data collection in process plants are covered next. CREDO, the Central Reliability Data Organization is described in the next chapter and is indexed separately, as is the chapter on DANTE, the fabrication reliability Data analysis system. Reliability data banks at Electricite de France and IAEA's experience in compiling a generic component reliability data base are also separately indexed. The European reliability data system, ERDS, and the development of a large data bank come next. The last three chapters look at 'Reliability data banks, - friend foe or a waste of time'? and future developments. (UK)

  19. An Introduction To Reliability

    International Nuclear Information System (INIS)

    Park, Kyoung Su

    1993-08-01

    This book introduces reliability with definition of reliability, requirement of reliability, system of life cycle and reliability, reliability and failure rate such as summary, reliability characteristic, chance failure, failure rate which changes over time, failure mode, replacement, reliability in engineering design, reliability test over assumption of failure rate, and drawing of reliability data, prediction of system reliability, conservation of system, failure such as summary and failure relay and analysis of system safety.

  20. Flat Files - JSNP | LSDB Archive [Life Science Database Archive metadata

    Lifescience Database Archive (English)

    Full Text Available switchLanguage; BLAST Search Image Search Home About Archive Update History Data ... Data file File name: jsnp_flat_files File URL: ftp://ftp.biosciencedbc.jp/archiv...his Database Database Description Download License Update History of This Database Site Policy | Contact Us Flat Files - JSNP | LSDB Archive ...

  1. Efficiency of the Self Adjusting File, WaveOne, Reciproc, ProTaper and hand files in root canal debridement.

    Science.gov (United States)

    Topcu, K Meltem; Karatas, Ertugrul; Ozsu, Damla; Ersoy, Ibrahim

    2014-07-01

    The aim of this study was to compare the canal debridement capabilities of three single file systems, ProTaper, and K-files in oval-shaped canals. Seventy-five extracted human mandibular central incisors with oval-shaped root canals were selected. A radiopaque contrast medium (Metapex; Meta Biomed Co. Ltd., Chungcheongbuk-do, Korea) was introduced into the canal systems and the self-adjusting file (SAF), WaveOne, Reciproc, ProTaper, and K-files were used for the instrumentation of the canals. The percentage of removed contrast medium was calculated using pre- and post-operative radiographs. An overall comparison between the groups revealed that the hand file (HF) and SAF groups presented the lowest percentage of removed contrast medium, whereas the WaveOne group showed the highest percentage (P ProTaper group removed more contrast medium than the SAF and HF groups (P < 0.05). None of the instruments was able to remove the contrast medium completely. WaveOne performed significantly better than other groups.

  2. Radionuclide methods in the diagnostics of osteomyelitis in the diabetic foot syndrome

    International Nuclear Information System (INIS)

    Lang, O.; Cincarova, E.; Treslova, L.; Andel, M.; Knotkova, V.; Chroustova, D.; Mala, M.

    1997-01-01

    31 diabetic patients with diabetic foot syndrome Wagner II-III were examined. At all patients the laboratory symptoms of the inflammation with the X-ray radiography, three phase scintigraphy of the skeleton with 99m Tc MDP or 99m Tc HDP and 99m Tc-Granulocyte were examined. The diagnosis of osteomyelitis in the diabetic foot syndrome with following long-time antibiotic therapy can be reliable determined in positive results of both radionuclide methods, first of all scintigraphy with labelled leucocytes

  3. Application of a digital technique in evaluating the reliability of shade guides.

    Science.gov (United States)

    Cal, E; Sonugelen, M; Guneri, P; Kesercioglu, A; Kose, T

    2004-05-01

    There appears to be a need for a reliable method for quantification of tooth colour and analysis of shade. Therefore, the primary objective of this study was to show the applicability of graphic software in colour analysis and secondly to investigate the reliability of commercial shade guides produced by the same manufacturer, using this digital technique. After confirming the reliability and reproducibility of the digital method by using self-assessed coloured images, three shade guides of the same manufacturer were photographed in daylight and in studio environments with a digital camera and saved in tagged image file format (TIFF) format. Colour analysis of each photograph was performed using the Adobe Photoshop 4.0 graphic program. Luminosity, and red, green, blue (L and RGB) values of each shade tab of each shade guide were measured and the data were subjected to statistical analysis using the repeated measure Anova test. The L and RGB values of the images taken in daylight differed significantly from those of the images taken in studio environment (P < 0.05). In both environments, the luminosity and red values of the shade tabs were significantly different from each other (P < 0.05). It was concluded that, when the environmental conditions were kept constant, the Adobe Photoshop 4.0 colour analysis program could be used to analyse the colour of images. On the other hand, the results revealed that the accuracy of shade tabs widely being used in colour matching should be readdressed.

  4. Physician-Supplier Procedure Summary Master File

    Data.gov (United States)

    U.S. Department of Health & Human Services — This file is a 100 percent summary of all Part B Carrier and DMERC Claims processed through the Common Working File and stored in the National Claims History...

  5. XML Files

    Science.gov (United States)

    ... this page: https://medlineplus.gov/xml.html MedlinePlus XML Files To use the sharing features on this page, please enable JavaScript. MedlinePlus produces XML data sets that you are welcome to download ...

  6. 49 CFR 1104.1 - Address, identification, and electronic filing option.

    Science.gov (United States)

    2010-10-01

    ... 2 of 4” and so forth). (e) Persons filing pleadings and documents with the Board have the option of electronically filing (e-filing) certain types of pleadings and documents instead of filing paper copies. Details regarding the types of pleadings and documents eligible for e-filing, the procedures to be followed, and...

  7. 77 FR 71412 - Combined Notice of Filings #2

    Science.gov (United States)

    2012-11-30

    ... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission Combined Notice of Filings 2 Take notice that the Commission has received the following Natural Gas Pipeline Rate and Refund Report filings: Filings Instituting Proceedings Docket Numbers: RP13-301-000. Applicants: Venice Gathering System, LLC...

  8. 76 FR 16398 - Combined Notice of Filings #3

    Science.gov (United States)

    2011-03-23

    .... Applicants: Bangor Hydro Electric Company. Description: Bangor Hydro Electric Company submits tariff filing... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission Combined Notice of Filings 3 Take notice that the Commission received the following electric rate filings: Docket Numbers: ER10-2288-004...

  9. 78 FR 67136 - Combined Notice of Filings #2

    Science.gov (United States)

    2013-11-08

    ...: Bangor Hydro Electric Company. Description: Bangor Hydro Electric Company submits Filing to Effect... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission Combined Notice of Filings 2 Take notice that the Commission received the following electric corporate filings: Docket Numbers: EC14-15-000...

  10. CONTINUOUS V/S RECIPROCATING FILE MOTION – A REVIEW

    OpenAIRE

    Samrithi Yuvaraj; Dr. S. Delphine Priscilla Antony

    2017-01-01

    Aim: To review the continuous and reciprocating file motions in endodontics Back Ground: The first endodontic file was crafted in the mid 1800’s. Thiis was basically a rudimentary k-file. K-files are, to these days. The most commonly used hand files in clinical practice. Automated instrumentation of the root canal was an early objective of clinical endodontics. Around 1992-1993, the first rotary NiTi instrument was introduced. These rotary NiTi instruments have undergone various modificat...

  11. CryptoCache: A Secure Sharable File Cache for Roaming Users

    DEFF Research Database (Denmark)

    Jensen, Christian D.

    2000-01-01

    . Conventional distributed file systems cache everything locally or not at all; there is no possibility to cache files on nearby nodes.In this paper we present the design of a secure cache system called CryptoCache that allows roaming users to cache files on untrusted file hosting servers. The system allows...... flexible sharing of cached files among unauthenticated users, i.e. unlike most distributed file systems CryptoCache does not require a global authentication framework.Files are encrypted when they are transferred over the network and while stored on untrusted servers. The system uses public key......Small mobile computers are now sufficiently powerful to run many applications, but storage capacity remains limited so working files cannot be cached or stored locally. Even if files can be stored locally, the mobile device is not powerful enough to act as server in collaborations with other users...

  12. Benchmark comparisons of evaluated nuclear data files

    International Nuclear Information System (INIS)

    Resler, D.A.; Howerton, R.J.; White, R.M.

    1994-05-01

    With the availability and maturity of several evaluated nuclear data files, it is timely to compare the results of integral tests with calculations using these different files. We discuss here our progress in making integral benchmark tests of the following nuclear data files: ENDL-94, ENDF/B-V and -VI, JENDL-3, JEF-2, and BROND-2. The methods used to process these evaluated libraries in a consistent way into applications files for use in Monte Carlo calculations is presented. Using these libraries, we are calculating and comparing to experiment k eff for 68 fast critical assemblies of 233,235 U and 239 Pu with reflectors of various material and thickness

  13. Reliability calculations

    International Nuclear Information System (INIS)

    Petersen, K.E.

    1986-03-01

    Risk and reliability analysis is increasingly being used in evaluations of plant safety and plant reliability. The analysis can be performed either during the design process or during the operation time, with the purpose to improve the safety or the reliability. Due to plant complexity and safety and availability requirements, sophisticated tools, which are flexible and efficient, are needed. Such tools have been developed in the last 20 years and they have to be continuously refined to meet the growing requirements. Two different areas of application were analysed. In structural reliability probabilistic approaches have been introduced in some cases for the calculation of the reliability of structures or components. A new computer program has been developed based upon numerical integration in several variables. In systems reliability Monte Carlo simulation programs are used especially in analysis of very complex systems. In order to increase the applicability of the programs variance reduction techniques can be applied to speed up the calculation process. Variance reduction techniques have been studied and procedures for implementation of importance sampling are suggested. (author)

  14. 78 FR 62612 - Combined Notice of Filings #1

    Science.gov (United States)

    2013-10-22

    ... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission Combined Notice of Filings 1 Take notice that the Commission received the following electric corporate filings: Docket Numbers: EC14-3-000...: PE Hydro Generation, LLC Description: Self-Certification of EG of PE Hydro Generation, LLC. Filed...

  15. New Steganographic Techniques for the OOXML File Format

    OpenAIRE

    Castiglione , Aniello; D’Alessio , Bonaventura; Santis , Alfredo ,; Palmieri , Francesco

    2011-01-01

    Part 2: Workshop; International audience; The simplest container of digital information is the file and among the vast array of files currently available, MS-Office files are the most widely used. The “Microsoft Compound Document File Format” (MCDFF) has often been used to host secret information. The new format created by Microsoft, first used with MS-Office 2007, makes use of a new standard, the “Office Open XML Formats” (OOXML). The benefits include that the new format introduces the OOXML...

  16. An evaluated neutronic data file for elemental zirconium

    International Nuclear Information System (INIS)

    Smith, A.B.; Chiba, S.

    1994-09-01

    A comprehensive evaluated neutronic data file for elemental zirconium is derived and presented in the ENDF/B-VI formats. The derivation is based upon measured microscopic nuclear data, augmented by model calculations as necessary. The primary objective is a quality contemporary file suitable for fission-reactor development extending from conventional thermal to fast and innovative systems. This new file is a significant improvement over previously available evaluated zirconium files, in part, as a consequence of extensive new experimental measurements reported elsewhere

  17. 42 CFR 430.63 - Filing and service of papers.

    Science.gov (United States)

    2010-10-01

    ... 42 Public Health 4 2010-10-01 2010-10-01 false Filing and service of papers. 430.63 Section 430.63... Conformity of State Medicaid Plans and Practice to Federal Requirements § 430.63 Filing and service of papers. (a) Filing. All papers in the proceedings are filed with the CMS Docket Clerk, in an original and two...

  18. 45 CFR 1386.85 - Filing and service of papers.

    Science.gov (United States)

    2010-10-01

    ... 45 Public Welfare 4 2010-10-01 2010-10-01 false Filing and service of papers. 1386.85 Section 1386... Requirements General § 1386.85 Filing and service of papers. (a) All papers in the proceedings must be filed... transcripts of testimony need be filed. (b) Copies of papers in the proceedings must be served on all parties...

  19. 10 CFR 13.26 - Filing and service of papers.

    Science.gov (United States)

    2010-01-01

    ... found in the E-Filing Guidance and on the NRC Web site at http://www.nrc.gov/site-help/e-submittals.html... electronically to the E-Filing system. In addition, optical storage media (OSM) containing the entire filing must... document (e.g., motion to quash subpoena). (6) Filing is complete when the filer performs the last act that...

  20. 78 FR 49741 - Combined Notice of Filings #1

    Science.gov (United States)

    2013-08-15

    ... that the Commission received the following electric rate filings: Docket Numbers: ER12-1155-001...: ER13-2118-000. Applicants: NedPower Mount Storm, LLC. Description: Compliance Filing--NedPower MBR.../13. Docket Numbers: ER13-2120-000. Applicants: Bangor Hydro Electric Company. Description: Filing of...

  1. 77 FR 37397 - Combined Notice of Filings #1

    Science.gov (United States)

    2012-06-21

    ..., Emera Energy U.S. Subsidiary No. 2, Inc., Bangor Hydro Electric Company. Description: Change in Status Filing of Bangor Hydro Electric Company, et al. Filed Date: 6/13/12. Accession Number: 20120613-5023... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission Combined Notice of Filings 1 Take notice...

  2. 75 FR 23752 - Combined Notice of Filings #1

    Science.gov (United States)

    2010-05-04

    ...Corp. Description: PacifiCorp submits Revised Network Integration Transmission Service Agreement dated... Network Integration Transmission Service Agreement et al. Filed Date: 04/26/2010. Accession Numbers... filing per 35.12: Initial Market Based Rates to be effective 6/1/2010. Filed Date: 04/27/2010. Accession...

  3. 78 FR 69407 - Combined Notice of Filings #1

    Science.gov (United States)

    2013-11-19

    ... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission Combined Notice of Filings 1 Take notice that the Commission received the following electric corporate filings: Docket Numbers: EC14-24-000... of Eldorado Co-Tenancy and Communication Agreement to be effective 1/1/2014. Filed Date: 11/7/13...

  4. 46 CFR 232.6 - Financial report filing requirement.

    Science.gov (United States)

    2010-10-01

    ... RELATED ACTIVITIES UNIFORM FINANCIAL REPORTING REQUIREMENTS Income Statement § 232.6 Financial report filing requirement. (a) Reporting Frequency and Due Dates. The contractor shall file a semiannual... 46 Shipping 8 2010-10-01 2010-10-01 false Financial report filing requirement. 232.6 Section 232.6...

  5. Training the next generation of research mentors: the University of California, San Francisco, Clinical & Translational Science Institute Mentor Development Program.

    Science.gov (United States)

    Feldman, Mitchell D; Huang, Laurence; Guglielmo, B Joseph; Jordan, Richard; Kahn, James; Creasman, Jennifer M; Wiener-Kronish, Jeanine P; Lee, Kathryn A; Tehrani, Ariane; Yaffe, Kristine; Brown, Jeanette S

    2009-06-01

    Mentoring is a critical component of career development and success for clinical translational science research faculty. Yet few programs train faculty in mentoring skills. We describe outcomes from the first two faculty cohorts who completed a Mentor Development Program (MDP) at UCSF. Eligibility includes having dedicated research time, expertise in a scientific area and a desire to be a lead research mentor. A post-MDP survey measured the program's impact on enhancement of five key mentoring skills, change in the Mentors-in-Training (MIT) self-rated importance of being a mentor to their career satisfaction, and overall confidence in their mentoring skills. Since 2007, 29 MITs participated in and 26 completed the MDP. Only 15% of the MITs reported any previous mentor training. Overall, 96% of MITs felt that participation in the MDP helped them to become better mentors. A majority reported a significant increase in confidence in mentoring skills and most reported an increased understanding of important mentoring issues at UCSF. MITs reported increased confidence in overall and specific mentoring skills after completion of the MDP. The MDP can serve as a model for other institutions to develop the next generation of clinical-translational research mentors.

  6. Performance of the Galley Parallel File System

    Science.gov (United States)

    Nieuwejaar, Nils; Kotz, David

    1996-01-01

    As the input/output (I/O) needs of parallel scientific applications increase, file systems for multiprocessors are being designed to provide applications with parallel access to multiple disks. Many parallel file systems present applications with a conventional Unix-like interface that allows the application to access multiple disks transparently. This interface conceals the parallism within the file system, which increases the ease of programmability, but makes it difficult or impossible for sophisticated programmers and libraries to use knowledge about their I/O needs to exploit that parallelism. Furthermore, most current parallel file systems are optimized for a different workload than they are being asked to support. We introduce Galley, a new parallel file system that is intended to efficiently support realistic parallel workloads. Initial experiments, reported in this paper, indicate that Galley is capable of providing high-performance 1/O to applications the applications that rely on them. In Section 3 we describe that access data in patterns that have been observed to be common.

  7. Pavement maintenance optimization model using Markov Decision Processes

    Science.gov (United States)

    Mandiartha, P.; Duffield, C. F.; Razelan, I. S. b. M.; Ismail, A. b. H.

    2017-09-01

    This paper presents an optimization model for selection of pavement maintenance intervention using a theory of Markov Decision Processes (MDP). There are some particular characteristics of the MDP developed in this paper which distinguish it from other similar studies or optimization models intended for pavement maintenance policy development. These unique characteristics include a direct inclusion of constraints into the formulation of MDP, the use of an average cost method of MDP, and the policy development process based on the dual linear programming solution. The limited information or discussions that are available on these matters in terms of stochastic based optimization model in road network management motivates this study. This paper uses a data set acquired from road authorities of state of Victoria, Australia, to test the model and recommends steps in the computation of MDP based stochastic optimization model, leading to the development of optimum pavement maintenance policy.

  8. Creating and Viewing HTML Files with Python

    OpenAIRE

    William J. Turkel; Adam Crymble

    2012-01-01

    This lesson uses Python to create and view an HTML file. If you write programs that output HTML, you can use any browser to look at your results. This is especially convenient if your program is automatically creating hyperlinks or graphic entities like charts and diagrams. Here you will learn how to create HTML files with Python scripts, and how to use Python to automatically open an HTML file in Firefox.

  9. Methods and Algorithms for Detecting Objects in Video Files

    Directory of Open Access Journals (Sweden)

    Nguyen The Cuong

    2018-01-01

    Full Text Available Video files are files that store motion pictures and sounds like in real life. In today's world, the need for automated processing of information in video files is increasing. Automated processing of information has a wide range of application including office/home surveillance cameras, traffic control, sports applications, remote object detection, and others. In particular, detection and tracking of object movement in video file plays an important role. This article describes the methods of detecting objects in video files. Today, this problem in the field of computer vision is being studied worldwide.

  10. Reliability and Validity of the Medical Outcomes Study Short Form-12 Version 2 (SF-12v2) in Adults with Non-Cancer Pain

    Science.gov (United States)

    Hayes, Corey J.; Bhandari, Naleen Raj; Kathe, Niranjan; Payakachat, Nalin

    2017-01-01

    Limited evidence exists on how non-cancer pain (NCP) affects an individual’s health-related quality of life (HRQoL). This study aimed to validate the Medical Outcomes Study Short Form-12 Version 2 (SF-12v2), a generic measure of HRQoL, in a NCP cohort using the Medical Expenditure Panel Survey Longitudinal Files. The SF Mental Component Summary (MCS12) and SF Physical Component Summary (PCS12) were tested for reliability (internal consistency and test-retest reliability) and validity (construct: convergent and discriminant; criterion: concurrent and predictive). A total of 15,716 patients with NCP were included in the final analysis. The MCS12 and PCS12 demonstrated high internal consistency (Cronbach’s alpha and Mosier’s alpha > 0.8), and moderate and high test-retest reliability, respectively (MCS12 intraclass correlation coefficient (ICC): 0.64; PCS12 ICC: 0.73). Both scales were significantly associated with a number of chronic conditions (p reliable and valid measure of HRQoL for patients with NCP. PMID:28445438

  11. A novel platform for in vitro analysis of torque, forces, and three-dimensional file displacements during root canal preparations: application to ProTaper rotary files.

    Science.gov (United States)

    Diop, Amadou; Maurel, Nathalie; Oiknine, Michel; Patoor, Etienne; Machtou, Pierre

    2009-04-01

    We proposed a new testing setup and in vitro experimental procedure allowing the analysis of the forces, torque, and file displacements during the preparation of root canals using nickel-titanium rotary endodontic files. We applied it to the preparation of 20 fresh frozen cadaveric teeth using ProTaper files (Dentsply Maillefer, Ballaigues, Switzerland), according to a clinically used sequence. During the preparations, a clinical hand motion was performed by an endodontist, and we measured the applied torque around the file axis and also the involved three-dimensional forces and 3-dimensional file displacements. Such a biomechanical procedure is useful to better understand the working conditions of the files in terms of loads and displacements. It could be used to analyze the effects of various mechanical and geometric parameters on the files' behavior and to get data for modelling purposes. Finally, it could contribute to studies aiming to improve files design in order to reduce the risks of file fractures.

  12. A fortran code CVTRAN to provide cross-section file for TWODANT by using macroscopic file written by SRAC

    International Nuclear Information System (INIS)

    Yamane, Tsuyoshi; Tsuchihashi, Keichiro

    1999-03-01

    A code CVTRAN provides the macroscopic cross-sections in the format of XSLIB file which is one of Standard interface files for a two-dimensional Sn transport code TWODANT by reading a macroscopic cross section file in the PDS format which is prepared by SRAC execution. While a two-dimensional Sn transport code TWOTRAN published by LANL is installed as a module in the SRAC code system, several functions such as alpha search, concentration search, zone thickness search and various edits are suppressed. Since the TWODANT code was released from LANL, its short running time, stable convergence and plenty of edits have attracted many users. The code CVTRAN makes the TWODANT available to the SRAC user by providing the macroscopic cross-sections on a card-image file XSLIB. The CVTRAN also provides material dependent fission spectra into a card-image format file CVLIB, together with group velocities, group boundary energies and material names. The user can feed them into the TWODANT input, if necessary, by cut-and-paste command. (author)

  13. 78 FR 19475 - Combined Notice of Filings #1

    Science.gov (United States)

    2013-04-01

    ... Wholesale Generator Status of Alta Wind X, LLC. Filed Date: 3/21/13. Accession Number: 20130321-5127...: Notice of Self-Certification of Exempt Wholesale Generator Status of Alta Wind XI, LLC. Filed Date: 3/21... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission Combined Notice of Filings 1 Take notice...

  14. 78 FR 62345 - Combined Notice of Filings #2

    Science.gov (United States)

    2013-10-18

    ... Generator Status of Miami Wind I LLC. Filed Date: 10/9/13. Accession Number: 20131009-5053. Comments Due: 5... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission Combined Notice of Filings 2 Take notice that the Commission received the following exempt wholesale generator filings: Docket Numbers: EG14-3...

  15. 75 FR 61733 - Combined Notice of Filings #1

    Science.gov (United States)

    2010-10-06

    ... MBR Tariff making the required change. Filed Date: 09/27/2010. Accession Number: 20100928-0206... Grove MBR Baseline to be effective 9/27/2010. Filed Date: 09/27/2010. Accession Number: 20100927-5227..., LLC. Description: Champion Energy Services, LLC submits tariff filing per 35.12: MBR application to be...

  16. 76 FR 64937 - Combined Notice of Filings #1

    Science.gov (United States)

    2011-10-19

    .... Description: Lockhart Power Company submits tariff filing per 35: Revisions to Lockhart MBR Tariff to be... Inc. Description: Alcoa Power Generating Inc. submits tariff filing per 35: APGI Revisions to MBR...: APM Revisions to MBR Tariff--Seller Category to be effective 10/12/ 2011. Filed Date: 10/11/2011...

  17. 76 FR 12353 - Combined Notice of Filings #2

    Science.gov (United States)

    2011-03-07

    ... PowerSecure Inc. at Washington, NC Walmart. Filed Date: 07/02/2010. Accession Number: 20100702-5029...: Self-Certification of PowerSecure Inc. at Laurinburg, NC Walmart. Filed Date: 07/02/2010. Accession...Secure, Inc. Description: Self-Certification of PowerSecure Inc. at Wilson, NC Walmart. Filed Date: 07/02...

  18. 37 CFR 401.16 - Electronic filing.

    Science.gov (United States)

    2010-07-01

    ... 37 Patents, Trademarks, and Copyrights 1 2010-07-01 2010-07-01 false Electronic filing. 401.16 Section 401.16 Patents, Trademarks, and Copyrights ASSISTANT SECRETARY FOR TECHNOLOGY POLICY, DEPARTMENT... GOVERNMENT GRANTS, CONTRACTS, AND COOPERATIVE AGREEMENTS § 401.16 Electronic filing. Unless otherwise...

  19. 76 FR 23222 - Electric Reliability Organization Interpretation of Transmission Operations Reliability

    Science.gov (United States)

    2011-04-26

    ....3d 1342 (DC Cir. 2009). \\5\\ Mandatory Reliability Standards for the Bulk-Power System, Order No. 693... Reliability Standards for the Bulk-Power System. Action: FERC-725A. OMB Control No.: 1902-0244. Respondents...] Electric Reliability Organization Interpretation of Transmission Operations Reliability AGENCY: Federal...

  20. Endodontic complications of root canal therapy performed by dental students with stainless-steel K-files and nickel-titanium hand files.

    Science.gov (United States)

    Pettiette, M T; Metzger, Z; Phillips, C; Trope, M

    1999-04-01

    Straightening of curved canals is one of the most common procedural errors in endodontic instrumentation. This problem is commonly encountered when dental students perform molar endodontics. The purpose of this study was to compare the effect of the type of instrument used by these students on the extent of straightening and on the incidence of other endodontic procedural errors. Nickel-titanium 0.02 taper hand files were compared with traditional stainless-steel 0.02 taper K-files. Sixty molar teeth comprised of maxillary and mandibular first and second molars were treated by senior dental students. Instrumentation was with either nickel-titanium hand files or stainless-steel K-files. Preoperative and postoperative radiographs of each tooth were taken using an XCP precision instrument with a customized bite block to ensure accurate reproduction of radiographic angulation. The radiographs were scanned and the images stored as TIFF files. By superimposing tracings from the preoperative over the postoperative radiographs, the degree of deviation of the apical third of the root canal filling from the original canal was measured. The presence of other errors, such as strip perforation and instrument breakage, was established by examining the radiographs. In curved canals instrumented by stainless-steel K-files, the average deviation of the apical third of the canals was 14.44 degrees (+/- 10.33 degrees). The deviation was significantly reduced when nickel-titanium hand files were used to an average of 4.39 degrees (+/- 4.53 degrees). The incidence of other procedural errors was also significantly reduced by the use of nickel-titanium hand files.

  1. The design and development of GRASS file reservation system

    International Nuclear Information System (INIS)

    Huang Qiulan; Zhu Suijiang; Cheng Yaodong; Chen Gang

    2010-01-01

    GFRS (GRASS File Reservation System) is designed to improve the file access performance of GRASS (Grid-enabled Advanced Storage System) which is a Hierarchical Storage Management (HSM) system developed at Computing Center, Institute of High Energy Physics. GRASS can provide massive storage management and data migration, but the data migration policy is simply based factors such as pool water level, the intervals for migration and so on, so it is short of precise control over files. As for that, we design GFRS to implement user-based file reservation which is to reserve and keep the required files on disks for High Energy physicists. CFRS can improve file access speed for users by avoiding migrating frequently accessed files to tapes. In this paper we first give a brief introduction of GRASS system and then detailed architecture and implementation of GFRS. Experiments results from GFRS have shown good performance and a simple analysis is made based on it. (authors)

  2. 76 FR 10890 - Combined Notice of Filings #1

    Science.gov (United States)

    2011-02-28

    ... Paris Amended and Restated Service Agreement to be effective 4/19/2011. Filed Date: 02/18/2011...: PacifiCorp submits tariff filing per 35.13(a)(2)(iii: PacifiCorp Energy Facilities Maintenance Agreement... Interconnection Agreement of Southwest Power Pool, Inc. Filed Date: 02/18/2011. Accession Number: 20110218-5086...

  3. 78 FR 31914 - Combined Notice of Filings #1

    Science.gov (United States)

    2013-05-28

    ... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission Combined Notice of Filings 1 Take notice...: ISO New England Inc. Rhode Island Engine Genco LLC Resource Termination Filing. Filed Date: 5/17/13... information, call (866) 208-3676 (toll free). For TTY, call (202) 502-8659. Dated: May 17, 2013. Nathaniel J...

  4. 75 FR 61726 - Combined Notice of Filings #1

    Science.gov (United States)

    2010-10-06

    ... submits a Notice of Cancellation of their market-based rate schedule, Electric Rate Schedule FERC 1. Filed...: Palama, LLC submits tariff filing per 35.12: Palama, LLC Baseline Market-Based Rate Tariff Filing to be... Time on Tuesday, October 12, 2010. Docket Numbers: ER10-2811-000. Applicants: Barclays Bank PLC...

  5. 76 FR 73610 - Combined Notice of Filings #1

    Science.gov (United States)

    2011-11-29

    ... that the Commission received the following electric corporate filings: Docket Numbers: EC12-33-000... electric rate filings: Docket Numbers: ER11-3876-003; ER11-2044-004; ER10-2611-002. Applicants: MidAmerican.... Docket Numbers: ER12-431-000. Applicants: NedPower Mount Storm, LLC. Description: Compliance Filing...

  6. 12 CFR 516.130 - Where are comments filed?

    Science.gov (United States)

    2010-01-01

    ... 12 Banks and Banking 5 2010-01-01 2010-01-01 false Where are comments filed? 516.130 Section 516.130 Banks and Banking OFFICE OF THRIFT SUPERVISION, DEPARTMENT OF THE TREASURY APPLICATION PROCESSING PROCEDURES Comment Procedures § 516.130 Where are comments filed? A commenter must file with the appropriate...

  7. 75 FR 18827 - Combined Notice of Filings #1

    Science.gov (United States)

    2010-04-13

    ...-Certification of Exempt Wholesale Generator Status of Butler Ridge Wind Energy Center, LLC. Filed Date: 04/06...-Certification of Exempt Wholesale Generator Status of High Majestic Wind Energy Center, LLC. Filed Date: 04/06...-Certification of Exempt Wholesale Generator Status of Wessington Wind Energy Center, LLC. Filed Date: 04/06/2010...

  8. 76 FR 46790 - Combined Notice of Filings #1

    Science.gov (United States)

    2011-08-03

    .... Applicants: Orange Grove Energy, L.P. Description: J-Power North America Holdings Co. Ltd Supplemental Filing of Notification of Non-Material Change in Status Orange Grove Energy, L.P. Filed Date: 07/14/2011...: Upper Peninsula Power Company submits tariff filing per 35.12: Metering Agent Agreement between WPPI, L...

  9. Study and development of a document file system with selective access

    International Nuclear Information System (INIS)

    Mathieu, Jean-Claude

    1974-01-01

    The objective of this research thesis was to design and to develop a set of software aimed at an efficient management of a document file system by using methods of selective access to information. Thus, the three main aspects of file processing (creation, modification, reorganisation) have been addressed. The author first presents the main problems related to the development of a comprehensive automatic documentation system, and their conventional solutions. Some future aspects, notably dealing with the development of peripheral computer technology, are also evoked. He presents the characteristics of INIS bibliographic records provided by the IAEA which have been used to create the files. In the second part, he briefly describes the file system general organisation. This system is based on the use of two main files: an inverse file which contains for each descriptor a list of of numbers of files indexed by this descriptor, and a dictionary of descriptor or input file which gives access to the inverse file. The organisation of these both files is then describes in a detailed way. Other related or associated files are created, and the overall architecture and mechanisms integrated into the file data input software are described, as well as various processing applied to these different files. Performance and possible development are finally discussed

  10. 76 FR 23171 - Electric Reliability Organization Interpretations of Interconnection Reliability Operations and...

    Science.gov (United States)

    2011-04-26

    ... Reliability Standards for the Bulk-Power System, Order No. 693, FERC Stats. & Regs. ] 31,242, order on reh'g...-Power System reliability may request an interpretation of a Reliability Standard.\\7\\ The ERO's standards... information in its reliability assessments. The Reliability Coordinator must monitor Bulk Electric System...

  11. 76 FR 55899 - Combined Notice of Filings No. 2

    Science.gov (United States)

    2011-09-09

    .... Applicants: Panther Interstate Pipeline Energy, LLC. Description: Panther Interstate Pipeline Energy, LLC submits tariff filing per 154.402: Panther 2011 ACA Filing to be effective 10/1/2011. Filed Date: 09/01...

  12. SU-E-T-473: A Patient-Specific QC Paradigm Based On Trajectory Log Files and DICOM Plan Files

    International Nuclear Information System (INIS)

    DeMarco, J; McCloskey, S; Low, D; Moran, J

    2014-01-01

    Purpose: To evaluate a remote QC tool for monitoring treatment machine parameters and treatment workflow. Methods: The Varian TrueBeamTM linear accelerator is a digital machine that records machine axis parameters and MLC leaf positions as a function of delivered monitor unit or control point. This information is saved to a binary trajectory log file for every treatment or imaging field in the patient treatment session. A MATLAB analysis routine was developed to parse the trajectory log files for a given patient, compare the expected versus actual machine and MLC positions as well as perform a cross-comparison with the DICOM-RT plan file exported from the treatment planning system. The parsing routine sorts the trajectory log files based on the time and date stamp and generates a sequential report file listing treatment parameters and provides a match relative to the DICOM-RT plan file. Results: The trajectory log parsing-routine was compared against a standard record and verify listing for patients undergoing initial IMRT dosimetry verification and weekly and final chart QC. The complete treatment course was independently verified for 10 patients of varying treatment site and a total of 1267 treatment fields were evaluated including pre-treatment imaging fields where applicable. In the context of IMRT plan verification, eight prostate SBRT plans with 4-arcs per plan were evaluated based on expected versus actual machine axis parameters. The average value for the maximum RMS MLC error was 0.067±0.001mm and 0.066±0.002mm for leaf bank A and B respectively. Conclusion: A real-time QC analysis program was tested using trajectory log files and DICOM-RT plan files. The parsing routine is efficient and able to evaluate all relevant machine axis parameters during a patient treatment course including MLC leaf positions and table positions at time of image acquisition and during treatment

  13. Files synchronization from a large number of insertions and deletions

    Science.gov (United States)

    Ellappan, Vijayan; Kumari, Savera

    2017-11-01

    Synchronization between different versions of files is becoming a major issue that most of the applications are facing. To make the applications more efficient a economical algorithm is developed from the previously used algorithm of “File Loading Algorithm”. I am extending this algorithm in three ways: First, dealing with non-binary files, Second backup is generated for uploaded files and lastly each files are synchronized with insertions and deletions. User can reconstruct file from the former file with minimizing the error and also provides interactive communication by eliminating the frequency without any disturbance. The drawback of previous system is overcome by using synchronization, in which multiple copies of each file/record is created and stored in backup database and is efficiently restored in case of any unwanted deletion or loss of data. That is, to introduce a protocol that user B may use to reconstruct file X from file Y with suitably low probability of error. Synchronization algorithms find numerous areas of use, including data storage, file sharing, source code control systems, and cloud applications. For example, cloud storage services such as Drop box synchronize between local copies and cloud backups each time users make changes to local versions. Similarly, synchronization tools are necessary in mobile devices. Specialized synchronization algorithms are used for video and sound editing. Synchronization tools are also capable of performing data duplication.

  14. Creating and Viewing HTML Files with Python

    Directory of Open Access Journals (Sweden)

    William J. Turkel

    2012-07-01

    Full Text Available This lesson uses Python to create and view an HTML file. If you write programs that output HTML, you can use any browser to look at your results. This is especially convenient if your program is automatically creating hyperlinks or graphic entities like charts and diagrams. Here you will learn how to create HTML files with Python scripts, and how to use Python to automatically open an HTML file in Firefox.

  15. Algorithms and file structures for computational geometry

    International Nuclear Information System (INIS)

    Hinrichs, K.; Nievergelt, J.

    1983-01-01

    Algorithms for solving geometric problems and file structures for storing large amounts of geometric data are of increasing importance in computer graphics and computer-aided design. As examples of recent progress in computational geometry, we explain plane-sweep algorithms, which solve various topological and geometric problems efficiently; and we present the grid file, an adaptable, symmetric multi-key file structure that provides efficient access to multi-dimensional data along any space dimension. (orig.)

  16. RAMA: A file system for massively parallel computers

    Science.gov (United States)

    Miller, Ethan L.; Katz, Randy H.

    1993-01-01

    This paper describes a file system design for massively parallel computers which makes very efficient use of a few disks per processor. This overcomes the traditional I/O bottleneck of massively parallel machines by storing the data on disks within the high-speed interconnection network. In addition, the file system, called RAMA, requires little inter-node synchronization, removing another common bottleneck in parallel processor file systems. Support for a large tertiary storage system can easily be integrated in lo the file system; in fact, RAMA runs most efficiently when tertiary storage is used.

  17. Controlling P2P File-Sharing Networks Traffic

    OpenAIRE

    García Pineda, Miguel; HAMMOUMI, MOHAMMED; Canovas Solbes, Alejandro; Lloret, Jaime

    2011-01-01

    Since the appearance of Peer-To-Peer (P2P) file-sharing networks some time ago, many Internet users have chosen this technology to share and search programs, videos, music, documents, etc. The total number of P2P file-sharing users has been increasing and decreasing in the last decade depending on the creation or end of some well known P2P file-sharing systems. P2P file-sharing networks traffic is currently overloading some data networks and it is a major headache for netw...

  18. GABUNGAN ALGORITMA VERNAM CHIPER DAN END OF FILE UNTUK KEAMANAN DATA

    Directory of Open Access Journals (Sweden)

    Christy Atika Sari

    2014-10-01

    Full Text Available Adanya kesamaan fungsi pada  metode Kriptografi dan Steganografi untuk mengamankan data, maka makalah ini menggunakan algoritma Vernam Cipher sebagai salah satu algoritma yang popular pada Kriptografi dan End Of File (EOF pada metode Steganografi. Vernam Cipher mempunyai kemampuan untuk menyembunyikan data karena proses enkripsi dan dekripsi menggunakan sebuah kunci yang sama. Kunci ini berasal dari perhitungan XOR anatar bit plainteks dengan bit kunci. Sedangkan EOF dikenal sebagai pengembangan dari metode Least Significant Bit (LSB. EOF dapat digunakan untuk menyisipkan data yang ukurannya sesuai dengan kebutuhan. Pada penelitian ini digunakan file asli berformat .mp3 dan file spoofing berformat .pdf. file hasil stegano berhasil di ekstraksi menjadi file asli dan file spoofing. Ukuran file yang telah melalui proses penyisipan sama dengan ukuran file sebelum disisipkan data ditambah dengan ukuran data yang disisipkan ke dalam file tersebut. Kata Kunci: Vernam Chiper, End Of File, Kriptografi, Steganografi.

  19. Grid collector: An event catalog with automated file management

    International Nuclear Information System (INIS)

    Wu, Kesheng; Zhang, Wei-Ming; Sim, Alexander; Gu, Junmin; Shoshani, Arie

    2003-01-01

    High Energy Nuclear Physics (HENP) experiments such as STAR at BNL and ATLAS at CERN produce large amounts of data that are stored as files on mass storage systems in computer centers. In these files, the basic unit of data is an event. Analysis is typically performed on a selected set of events. The files containing these events have to be located, copied from mass storage systems to disks before analysis, and removed when no longer needed. These file management tasks are tedious and time consuming. Typically, all events contained in the files are read into memory before a selection is made. Since the time to read the events dominate the overall execution time, reading the unwanted event needlessly increases the analysis time. The Grid Collector is a set of software modules that works together to address these two issues. It automates the file management tasks and provides ''direct'' access to the selected events for analyses. It is currently integrated with the STAR analysis framework. The users can select events based on tags, such as, ''production date between March 10 and 20, and the number of charged tracks > 100.'' The Grid Collector locates the files containing relevant events, transfers the files across the Grid if necessary, and delivers the events to the analysis code through the familiar iterators. There has been some research efforts to address the file management issues, the Grid Collector is unique in that it addresses the event access issue together with the file management issues. This makes it more useful to a large variety of users

  20. Design of housing file box of fire academy based on RFID

    Science.gov (United States)

    Li, Huaiyi

    2018-04-01

    This paper presents a design scheme of intelligent file box based on RFID. The advantages of RFID file box and traditional file box are compared and analyzed, and the feasibility of RFID file box design is analyzed based on the actual situation of our university. After introducing the shape and structure design of the intelligent file box, the paper discusses the working process of the file box, and explains in detail the internal communication principle of the RFID file box and the realization of the control system. The application of the RFID based file box will greatly improve the efficiency of our school's archives management.