Sample records for mdab lnemaa koolilaste

  1. Ühispank noolib koolilaste seast endale uusi kliente / Triin Olvet

    Index Scriptorium Estoniae

    Olvet, Triin


    Ilmunud ka: Postimees : na russkom jazõke 17. apr. lk. 9. SEB Ühispanga tellimusel käivad mööda koole panga müügipartneri OÜ SalesForce esindajad, et leida koolilaste seast kliente uuele pangakaardile ISIC Scholar Electron. Selline müügikampaania on hämmeldust tekitanud paljudes lastevanemates. Lisa: ISIC Scholar Electron

  2. Läti koolilaste interferentsist eesti keele õppimisel / Marjo Mela

    Index Scriptorium Estoniae

    Mela, Marjo


    Artikli autor jälgis Riia Eesti kooli 1998. ja 1999.a. üheksanda klassi lõpetanute eesti keele õppega seotud probleeme. Riia Eesti kool on lätikeelne, peamine põhjus, miks vanemad oma lapsed eesti kooli panid, oli see, et kool on uus ja väike, etnilisusel ei olnud vanemate silmis tähtsust

  3. Kas heategu või koolide ärakasutamine? / Ralf-Martin Soe

    Index Scriptorium Estoniae

    Soe, Ralf-Martin


    Snelli staadioni korda teinud ja tasuta koolilaste kasutusse andes saab ärimees Endel Siff Tallinnalt vastuteenet küsida. Kommenteerib Lauri Leesi. Vt. samas: Võtmeks Kopli liinid; Siff ja Keskerakond; Snelli staadion

  4. Eesti koolilaps sõnaraamatu kasutajana / Ruth Mägi

    Index Scriptorium Estoniae

    Mägi, Ruth


    Artiklis antakse ülevaade Eesti koolilaste seas 2004/2005. õppeaastal läbiviidud uuringust, mille eesmärk oli välja selgitada õpilasest sõnaraamatukasutaja harjumused ja kogemused, kasutusprobleemid ning rahulolu oma oskustega

  5. 1600 last õppis linnaökoloogiat / Askur Alas

    Index Scriptorium Estoniae

    Alas, Askur, 1973-


    27.01 lõppenud Tallinna Elukeskkonna projektis osales vabatahtlikult rohkem kui 1600 koolilast. Tallinna elukeskkonna probleemidele pühendatud projekt algas juba novembris, säästlikku mõtteviisi ja loodushoidlikku eluviisi propageerivaid üritusi on kavas ka edaspidi

  6. The in vitro immunogenic potential of caspase-3 proficient breast cancer cells with basal low immunogenicity is increased by hypofractionated irradiation. (United States)

    Kötter, Bernhard; Frey, Benjamin; Winderl, Markus; Rubner, Yvonne; Scheithauer, Heike; Sieber, Renate; Fietkau, Rainer; Gaipl, Udo S


    Radiotherapy is an integral part of breast cancer treatment. Immune activating properties of especially hypofractionated irradiation are in the spotlight of clinicians, besides the well-known effects of radiotherapy on cell cycle and the reduction of the clonogenic potential of tumor cells. Especially combination of radiotherapy with further immune stimulation induces immune-mediated anti-tumor responses. We therefore examined whether hypofractionated irradiation alone or in combination with hyperthermia as immune stimulants is capable of inducing breast cancer cells with immunogenic potential. Clonogenic assay, AnnexinA5-FITC/Propidium iodide assay and ELISA analyses of heat shock protein 70 and high mobility group box 1 protein were applied to characterize colony forming capability, cell death induction, cell death forms and release of danger signals by breast cancer cells in response to hypofractionated radiation (4x4Gy, 6x3Gy) alone and in combination with hyperthermia (41.5 °C for 1 h). Caspase-3 deficient, hormone receptor positive, p53 wild type MCF-7 and caspase-3 intact, hormone receptor negative, p53 mutated MDA-MB231 breast cancer cells, the latter in absence or presence of the pan-caspase inhibitor zVAD-fmk, were used. Supernatants of the treated tumor cells were analyzed for their potential to alter the surface expression of activation markers on human-monocyte-derived dendritic cells. Irradiation reduced the clonogenicity of caspase deficient MCF-7 cells more than of MDA-B231 cells. In contrast, higher amounts of apoptotic and necrotic cells were induced in MDA-B231 cells after single irradiation with 4Gy, 10Gy, or 20Gy or after hypofractionated irradiation with 4x4Gy or 6x3Gy. MDA-B231 cells consecutively released higher amounts of Hsp70 and HMGB1 after hypofractionated irradiation. However, only the release of Hsp70 was further increased by hyperthermia. Both, apoptosis induction and release of the danger signals, was dependent on caspase-3. Only

  7. Chemical hazard evaluation of material disposal area (MDA) B closure project

    Energy Technology Data Exchange (ETDEWEB)

    Laul, Jagdish C [Los Alamos National Laboratory


    TA-21, MDA-B (NES) is the 'contaminated dump,' landfill with radionuclides and chemicals from process waste disposed in 1940s. This paper focuses on chemical hazard categorization and hazard evaluation of chemicals of concern (e.g., peroxide, beryllium). About 170 chemicals were disposed in the landfill. Chemicals included products, unused and residual chemicals, spent, waste chemicals, non-flammable oils, mineral oil, etc. MDA-B was considered a High hazard site. However, based on historical records and best engineering judgment, the chemical contents are probably at best 5% of the chemical inventory. Many chemicals probably have oxidized, degraded or evaporated for volatile elements due to some fire and limited shelf-life over 60 yrs, which made it possible to downgrade from High to Low chemical hazard site. Knowing the site history and physical and chemical properties are very important in characterizing a NES site. Public site boundary is only 20 m, which is a major concern. Chemicals of concern during remediation are peroxide that can cause potential explosion and beryllium exposure due to chronic beryllium disease (CBD). These can be prevented or mitigated using engineering control (EC) and safety management program (SMP) to protect the involved workers and public.

  8. Comparative genomic characterization of Francisella tularensis strains belonging to low and high virulence subspecies.

    Directory of Open Access Journals (Sweden)

    Mia D Champion


    Full Text Available Tularemia is a geographically widespread, severely debilitating, and occasionally lethal disease in humans. It is caused by infection by a gram-negative bacterium, Francisella tularensis. In order to better understand its potency as an etiological agent as well as its potential as a biological weapon, we have completed draft assemblies and report the first complete genomic characterization of five strains belonging to the following different Francisella subspecies (subsp.: the F. tularensis subsp. tularensis FSC033, F. tularensis subsp. holarctica FSC257 and FSC022, and F. tularensis subsp. novicida GA99-3548 and GA99-3549 strains. Here, we report the sequencing of these strains and comparative genomic analysis with recently available public Francisella sequences, including the rare F. tularensis subsp. mediasiatica FSC147 strain isolate from the Central Asian Region. We report evidence for the occurrence of large-scale rearrangement events in strains of the holarctica subspecies, supporting previous proposals that further phylogenetic subdivisions of the Type B clade are likely. We also find a significant enrichment of disrupted or absent ORFs proximal to predicted breakpoints in the FSC022 strain, including a genetic component of the Type I restriction-modification defense system. Many of the pseudogenes identified are also disrupted in the closely related rarely human pathogenic F. tularensis subsp. mediasiatica FSC147 strain, including modulator of drug activity B (mdaB (FTT0961, which encodes a known NADPH quinone reductase involved in oxidative stress resistance. We have also identified genes exhibiting sequence similarity to effectors of the Type III (T3SS and components of the Type IV secretion systems (T4SS. One of the genes, msrA2 (FTT1797c, is disrupted in F. tularensis subsp. mediasiatica and has recently been shown to mediate bacterial pathogen survival in host organisms. Our findings suggest that in addition to the duplication of