WorldWideScience

Sample records for md lisa begg

  1. Begg orthodontic therapy in retrospect

    NARCIS (Netherlands)

    Levin, Raymond Israel

    1975-01-01

    The purpose of the investigation described in this thesis was to study in retrospect a number of changes of the dentition, its occlusion and the facial skeleton which occurred in the treatment and posttreatment periods in a sample of 30 cases treated with the Begg fixed appliance techniques.

  2. The Begg's uprighting spring - Revisited.

    Science.gov (United States)

    Kumar, Vinay; Sundareswaran, Shobha

    2015-01-01

    Uprighting springs, an integral part of the Begg ligsht wire differential force technique is gaining more and more popularity, as a useful adjunct in contemporary preadjusted edgewise appliance systems as well. It can be used with brackets containing vertical slots for mesiodistal crown uprighting, or as braking auxiliaries providing additional anchorage while protracting posteriors. Here, we present a simple and quick chair side method of fabricating and customizing uprighting springs according to the required crown/root movement for correction. This communication would serve as a ready reckoner during fabrication of the springs, thus dispelling the confusion that usually arises regarding direction and position of the coil and active arm.

  3. Rightsizing LISA

    International Nuclear Information System (INIS)

    Stebbins, R T

    2009-01-01

    The Laser Interferometer Space Antenna (LISA) science requirements and conceptual design have been fairly stable for over a decade. In the interest of reducing costs, the LISA Project at NASA has looked for simplifications of the architecture, at downsizing of subsystems and at descopes of the entire mission. This is a natural activity of the formulation phase and one that is particularly timely in the current NASA budgetary context. There is, and will continue to be, enormous pressure for cost reduction from both ESA and NASA, reviewers and the broader research community. Here, the rationale for the baseline architecture is reviewed, and recent efforts to find simplifications and other reductions that might lead to savings are reported. A few possible simplifications have been found in the LISA baseline architecture. In the interest of exploring cost sensitivity, one moderate and one aggressive descope have been evaluated; the cost savings are modest and the loss of science is not.

  4. Australian aboriginal tooth succession, interproximal attrition, and Begg's theory.

    Science.gov (United States)

    Corruccini, R S

    1990-04-01

    In 1954, P.R. Begg analyzed interproximal attrition as a prehistorically universal mechanism to reduce tooth size. With modern processed diets and the virtual disappearance of constant interproximal attrition, Begg asserted, teeth remain too large for the arches and become crowded. Later investigators have questioned Begg's estimate of attritional tooth-size reduction, as well as aspects of his theory relating the succession sequence of permanent teeth to different malocclusions. The present paper examines the theory using longitudinal casts and records of modern Australian aborigines who are among the first generation lacking notable interproximal attrition thanks to a "modernized" diet. Deciduous and permanent tooth size, arch size, and occlusal relational variables were analyzed with respect to the expected occlusal outcomes in the absence of attritional tooth reduction. Permanent incisor overjet correlated with crowding status, as predicted by Begg. On the other hand, longer teeth did not relate to crowding in general nor to crowding in relevant local areas or during developmental stages. Unfavorable leeway space did not relate clearly to crowding or other malocclusions. Lowered correlations among structures and narrowness of the maxilla related more significantly to malocclusion. These results are in keeping with recent thinking that small jaws rather than large teeth underlie tooth/arch discrepancy.

  5. Egg temperature and embryonic metabolism of A- and B-eggs of ...

    African Journals Online (AJOL)

    Macaroni and rockhopper penguins lay two eggs but rear only one chick to independence. The eggs are markedly dimorphic in size and, although the smaller A-egg is laid several days before the B-egg, in nests where both eggs are incubated, the B-egg always hatches first. Incubation temperatures and embryonic oxygen ...

  6. The LISA Pathfinder Mission

    International Nuclear Information System (INIS)

    Armano, M; Audley, H; Born, M; Danzmann, K; Diepholz, I; Auger, G; Binetruy, P; Baird, J; Bortoluzzi, D; Brandt, N; Fitzsimons, E; Bursi, A; Caleno, M; Cavalleri, A; Cesarini, A; Dolesi, R; Ferroni, V; Cruise, M; Dunbar, N; Ferraioli, L

    2015-01-01

    LISA Pathfinder (LPF), the second of the European Space Agency's Small Missions for Advanced Research in Technology (SMART), is a dedicated technology validation mission for future spaceborne gravitational wave detectors, such as the proposed eLISA mission. LISA Pathfinder, and its scientific payload - the LISA Technology Package - will test, in flight, the critical technologies required for low frequency gravitational wave detection: it will put two test masses in a near-perfect gravitational free-fall and control and measure their motion with unprecedented accuracy. This is achieved through technology comprising inertial sensors, high precision laser metrology, drag-free control and an ultra-precise micro-Newton propulsion system. LISA Pathfinder is due to be launched in mid-2015, with first results on the performance of the system being available 6 months thereafter.The paper introduces the LISA Pathfinder mission, followed by an explanation of the physical principles of measurement concept and associated hardware. We then provide a detailed discussion of the LISA Technology Package, including both the inertial sensor and interferometric readout. As we approach the launch of the LISA Pathfinder, the focus of the development is shifting towards the science operations and data analysis - this is described in the final section of the paper (paper)

  7. LISA system design highlights

    Energy Technology Data Exchange (ETDEWEB)

    Sallusti, M [European Space Agency, ESTEC, Keplerlaan 1, 2200 AG Noordwijk ZH (Netherlands); Gath, P; Weise, D; Berger, M; Schulte, H R, E-mail: marcello.sallusti@esa.in, E-mail: peter.gath@astrium.eads.ne, E-mail: dennis.weise@astrium.eads.ne, E-mail: marcel.berger@astrium.eads.ne, E-mail: Hans.Reiner.Schulte@astrium.eads.ne [Astrium GmbH Satellites, Claude-Dornier-Str., 88039 Friedrichshafen (Germany)

    2009-05-07

    A contract, started in January 2005, was awarded to a consortium of Astrium GmbH and Astrium Ltd for the LISA Mission Formulation. The scope of the contract was the development of a reference design for the mission architecture and for the mission elements (with particular focus on the payload) and a successive phase of derivation of requirements, to be concluded with a mission design review. The technical starting point was the output of the previous LISA study formalized in the Final Technical Report, issued in the year 2000. During the design phase, different architecture concepts were identified and traded off, including the LISA orbits, the measurement scheme and the opto-mechanical architecture. During the Mission Design Review (July 2008) the consolidated mission baseline design, and the specifications of the flight elements and of the payload subsystem and major components were presented. This paper gives a brief overview of the major design points of the latest design of the LISA system.

  8. LISA system design highlights

    International Nuclear Information System (INIS)

    Sallusti, M; Gath, P; Weise, D; Berger, M; Schulte, H R

    2009-01-01

    A contract, started in January 2005, was awarded to a consortium of Astrium GmbH and Astrium Ltd for the LISA Mission Formulation. The scope of the contract was the development of a reference design for the mission architecture and for the mission elements (with particular focus on the payload) and a successive phase of derivation of requirements, to be concluded with a mission design review. The technical starting point was the output of the previous LISA study formalized in the Final Technical Report, issued in the year 2000. During the design phase, different architecture concepts were identified and traded off, including the LISA orbits, the measurement scheme and the opto-mechanical architecture. During the Mission Design Review (July 2008) the consolidated mission baseline design, and the specifications of the flight elements and of the payload subsystem and major components were presented. This paper gives a brief overview of the major design points of the latest design of the LISA system.

  9. LISA Pathfinder and eLISA news

    Science.gov (United States)

    Thorpe, James Ira; Mueller, Guido

    2014-01-01

    Two important gatherings of the space-based gravitational-wave detector community were held in Zurich, Switzerland this past March. The first was a meeting of the Science Working Team for LISA Pathfinder (LPF), a dedicated technology demonstrator mission for a future LISA-like gravitational wave observatory. LPF is entering an extremely exciting phase with launch less than 15 months away. All flight components for both the European science payload, known as the LISA Technology Package (LTP), and the NASA science payload, known as the Space Technology 7 Disturbance Reduction System (ST7-DRS), have been delivered and are undergoing integration. The final flight component for the spacecraft bus, a cold-gas thruster based on the successful GAIA design, will be delivered later this year. Current focus is on completing integration of the science payload (see Figures 1 and 2) and preparation for operations and data analysis. After a launch in Summer 2015, LPF will take approximately 90 days to reach its operational orbit around the Earth-Sun Lagrange point (L1), where it will begin science operations. After 90 days of LTP operations followed by 90 days of DRS operations, LPF will have completed its prime mission of paving the way for a space-based observatory of gravitational waves in the milliHertz band. Immediately following the meeting of the LPF team, the eLISA consortium held its third progress meeting. The consortium (www.elisascience.org) is the organizing body of the European space-based gravitational-wave community, and it was responsible for the "The Gravitational Universe" whitepaper that resulted in the November 2013 election of a gravitational-wave science theme for ESA's Cosmic Visions L3 opportunity. In preparation for an L3 mission concept call, which is expected later this decade, and for launch in the mid 2030s, the eLISA consortium members are coordinating technology development and mission study activities which will build on the LPF results. The final

  10. LISA and asteroids

    International Nuclear Information System (INIS)

    Vinet, Jean-Yves

    2006-01-01

    LISA is a joint ESA-NASA mission aiming for cosmic gravitational wave detection and analysis. We address here the question of a special kind of signal caused by asteroid encounters. We present a short theory of the detection of such signals

  11. LISA and the LTP

    International Nuclear Information System (INIS)

    Jennrich, O.

    2002-01-01

    The primary objective of the LISA (Laser Interferometer Space Antenna mission is the detection and observation of gravitational waves from massive black holes (MBH) and galactic binaries in the frequency range 10 -4 Hz ... 10 -1 Hz. This low-frequency range is inaccessible to ground-based interferometers due to the background of local gravitational noise and because ground-based interferometers are limited in length to a few kilometres. LISA is envisaged as an ESA/NASA collaborative project, selected an ESA cornerstone mission and included in NASA's strategic plan and with a nominal launch date in 2011. SMART-2 is primarily intended to demonstrate the key technologies for the ESA/NASA collaborative LISA cornerstone mission. The synergy with the technology being used for Darwin motivates the utilization of SMART-2 for both missions. To this end, SMART-2 will accommodate a LISA technology package (LTP), provided by European institutes and industry and possibly also a Disturbance Reduction System (DRS) that is very similar to the LTP and has the same goals but is provided by US institutes and industry

  12. Perawatan Teknik Begg Pada Maloklusi Klas I Dengan Kaninus Impaksi dan Insisivus Lateral Agenesis

    Directory of Open Access Journals (Sweden)

    Kristina Wijaya Gunawan

    2013-06-01

    Full Text Available Impaksi kaninus maksila sering dijumpai pada sisi palatal daripada labial. Agenesis adalah anomali pertumbuhan akibat tidak ada satu atau lebih benih gigi. Laporan kasus ini bertujuan memaparkan kemajuan perawatan kasus Maloklusi klas I dengan kaninus impaksi dan insisivus lateral agenesis menggunakan alat cekat teknik Begg. Seorang pasien usia 20 tahun datang mengeluhkan gigi-gigi depan atas dan bawah yang berjejal sehingga mengganggu penampilan. Perawatan bertujuan untuk koreksi Maloklusi Angle klas I tipe dentoskeletal dengan deepbite, crossbite gigi 25 terhadap 35, pergeseran midline dental maksila dan mandibula ke kanan sebesar 2,5 mm dan 3,0 mm, 13 impaksi vertikal pada sisi labial, 42 agenesis, dan edentulous parsial regio 36. Koreksi dilakukan dengan pencabutan 14, 25, pemanfaatan ruang bekas pencabutan 36 dan exposure gigi kaninus yang impaksi. Tahap pertama teknik Begg adalah leveling, unraveling, dan bite opening, diikuti dengan koreksi midline dan penutupan sisa ruang bekas pencabutan. Kesimpulan: perawataan ortodontik menggunakan teknik Begg yang dilakukan simultan dengan exposure kaninus impaksi labial dengan closed eruption technique dapat memberikan hasil yang memuaskan. Treatment for Class I Malocclusion with Impacted Canine and Agenesis Lateral Incisor Using Begg Technique. Maxillary canine impaction occurs commonly on the palatal than labial side. Agenesis is a developmental anomaly condition because of the absence of one or more tooth buds. This case report aims to explain the treatment progress of class I malocclusion with impacted canine and agenesis lateral incisor using fixed appliance through Begg technique. A 20-year-old female patient complained about her upper and lower anterior dental crowding that disturbed her appearance. The treatment aims to correct the Angle class I malocclusion dentoskeletal types with deepbite, crossbite 25 to 35, maxillary and mandibulary dental midline shift to the right by 2.5 mm and 3.0 mm

  13. Perawatan Ortodontik Kaninus Kiri Maksil Impaksi di Daerah Palatal dengan Alat Cekat Teknik Begg

    Directory of Open Access Journals (Sweden)

    E. Emil

    2016-10-01

    Full Text Available Latar Belakang: ketidakharmonisan ukuran rahang dengan gigi merupakan salah satu bentuk etiologi maloklusi yang diturunkan dan akan mempengaruhi susunan dan posisi gigi di dalam rahang. Impaksi gigi seperti molar ketiga atau gigi kaninus sering kita temui akibat tidak adanya ruang untuk gigi tersebut erupsi dan menyusun diri di dalam lengkung yang baik. Gigi kaninus memiliki peran penting di dalam mulut, selain untuk mastikasi, gigi ini juga memiliki peran menentukan dalam estetika susunan gigi. Senyum yang menarik tidak akan didapatkan tanpa adanya gigi kaninus di dalam lengkung. Kasus impaksi kaninus dapat dirawat menggunakan teknik Begg dengan proses windowing yang dilakukan oleh ahli bedah mulut. Tujuan: membantu erupsi gigi kaninus dengan bantuan alat orto cekat teknik Begg. Kasus: laki-laki 19 tahun mengeluhkan gigi depan rahang atas protusif langit-langit tergigit oleh gigi depan rahang bawah. Diagnosis: maloklusi Angle kelas II dengan hubungan skeletal kelas I disertai kondisi berjejal di daerah anterior dan gigitan dalam. Perawatan: menggunakan alat cekat teknik Begg dan windowing dengan pencabutan dua premolar pertama rahang atas serta prosedur windo. Kesimpulan: hasil menunjukkan gigi kaninus kiri rahang atas dapat erupsi dengan baik dan bisa diposisikan ke dalam lengkung dalam 5 bulan.   Background: Discrepancy in size between jaw and teeth is one of the etiology factor of malocclusion that genetically inherited and will affect teeth allignment and position within the jaw. Third molar and canine impaction frequently found because there is not enough space for theme to erupt and align themselfes in a good alignment. Canine have an important role in mastication as it is in facial aesthetic. Canine impaction can be treated with Begg technique and windowing process performed by oral surgeon. Purpose: to help impacted canine to erupt using fixed Begg appliance technique and windowing process. Case: 19 years old man complained of crowded

  14. Perawatan Maloklusi Pseudo Kelas III dengan Alat Ortodontik Cekat Teknik Begg

    Directory of Open Access Journals (Sweden)

    Robertus Meidiyanto

    2016-10-01

    Full Text Available Latar Belakang: Maloklusi Pseudo kelas III ditandai dengan hubungan yang tidak harmonis antara relasi anteroposterior rahang dan posisi mandibula terhadap maksila. Ketidakharmonisan tersebut dapat disebabkan karena mandibula yang normal dengan maksila retrusif. Maloklusi pseudo kelas III mempunyai perhitungan yang menunjukkan bentuk antara klas I dan skeletal klas III. Perbedaanya hanya pada sudut gonial dimana pada skeletal klas III sudutnya lebih tumpul, sedangkan pada sampel pseudo klas III, sudut gonial lebih mirip dengan klas I. Perawatan ortodontik dengan alat cekat teknik Begg dapat juga untuk merawat maloklusi Angle kelas III, termasuk maloklusi skeletal yang menyertainya. Tujuan: memaparkan perubahan dental dan skeletal setelah perawatan dengan alat cekat teknik Begg. Kasus: perempuan 20 tahun mengeluhkan gigi-gigi rahang atas ada yang tumbuh di belakang dan rahang bawah nyakil sehingga menganggu penampilan dan mengurangi rasa percaya diri. Diagnosis: Maloklusi Angle Klas III subdivisi serta hubungan skeletal klas III dengan maksila retrusif dan mandibula protusif disertai Crossbite: 12, 11, 21, 22 terhadap 34, 32,31, 41, 42, 43. Perawatan: menggunakan alat cekat teknik Begg tanpa pencabutan. Kesimpulan: Hasil menunjukkan crowded terkoreksi, overjet dan overbite terkoreksi, relasi molar menjadi klas I.   Background: Pseudo class III malocclusion characterized by disharmony between anteroposterior relationship of jaw and mandibulae position toward maxilla. This disharmony cause by normally shaped mandibles and underveloped maxillae. Pseudo clas III malocclusion is an intermediate form between class I and skeletal clas III malocclusion. The only exception was the gonial angle, which was generally more obtuse in the skeletal class III sample. Measurement of gonial angle in the pseudo class III sample was found to be rather similar to class I sample. Fixed Begg orthodontic appliance can be used to treat Angle’s class III malocclusion

  15. Perawatan Crossbite Posterior pada Maloklusi Angle Klas III dengan Alat Ortodontik Cekat Teknik Begg

    Directory of Open Access Journals (Sweden)

    Trio Wijayanto

    2011-12-01

    Full Text Available Latar Belakang: Crossbite posterior merupakan hubungan abnormal dari gigi-gigi posterior secara bukolingual pada rahang atas atau bawah pada saat kedua lengkung gigi berada dalam oklusi sentrik yang dapat terjadi pada satu atau kedua sisi rahang. Posterior crossbite adalah maloklusi yang paling sering muncul pada masa gigi susu dan awal gigi bercampur. Tujuan Perawatan: mengoreksi crossbite posterior dan mengembalikan fungsi pengunyahan yang baik. Kasus: Perempuan 20 tahun dengan maloklusi Angle klas III disertai crossbite posterior kanan, crowding rahang atas dan bawah. Penanganan: menggunakan alat cekat teknik Begg dengan pencabutan gigi premolar I rahang atas kiri, kedua premolar I rahang bawah, cross elastik, toe-in, dan toe out digunakan untuk koreksi crossbite. Kesimpulan: Perawatan crossbite posterior dengan teknik Begg menunjukkan hasil yang cukup memuaskan. Prognatik mandibula berkurang, crossbite terkoreksi, overjet normal, overbite normal, dan fungsi pengunyahan menjadi lebih baik.   Background: Posterior crossbite is defined as any abnormal bucal-lingual relations between posterior teeth of upper and lower jaw in centric occlusion which can occur in one side only or both. Posterior crossbite is one of the most prevalent malocclusion in primary and early mixed dentition. Purpose: to correct posterior and restore normal mastication. Case: 20 years old woman with Angle’s class II accompanied by posterior crossbite on the right side and crowding in anterior segment of upper and lower jaw. Management: using the Begg fixed appliance techniques with the extraction of upper left, and two lower first premolars. Cross elastic along with toe in and toe out on the main wire was used to correct posterior crossbite. Conclusion: Posterior crossbite treatment with Begg technique showed satisfactory results. Prognatism mandibula had reduced, regained normal overjet and overbite, and restored good mastication.

  16. Synthetic LISA: Simulating time delay interferometry in a model LISA

    International Nuclear Information System (INIS)

    Vallisneri, Michele

    2005-01-01

    We report on three numerical experiments on the implementation of Time-Delay Interferometry (TDI) for LISA, performed with Synthetic LISA, a C++/Python package that we developed to simulate the LISA science process at the level of scientific and technical requirements. Specifically, we study the laser-noise residuals left by first-generation TDI when the LISA armlengths have a realistic time dependence; we characterize the armlength-measurement accuracies that are needed to have effective laser-noise cancellation in both first- and second-generation TDI; and we estimate the quantization and telemetry bitdepth needed for the phase measurements. Synthetic LISA generates synthetic time series of the LISA fundamental noises, as filtered through all the TDI observables; it also provides a streamlined module to compute the TDI responses to gravitational waves according to a full model of TDI, including the motion of the LISA array and the temporal and directional dependence of the armlengths. We discuss the theoretical model that underlies the simulation, its implementation, and its use in future investigations on system-characterization and data-analysis prototyping for LISA

  17. Md Naimuddin

    Indian Academy of Sciences (India)

    Home; Journals; Pramana – Journal of Physics. Md Naimuddin. Articles written in Pramana – Journal of Physics. Volume 79 Issue 5 November 2012 pp 1255-1258 Poster Presentations. Model unspecific search for new physics in collision at s = 7 TeV · Shivali Malhotra Md Naimuddin Thomas Hebbeker Arnd Meyer ...

  18. Perawatan Maloklusi Angle Kelas I disertai Impaksi Kaninus Maksila Menggunakan Alat Cekat Begg

    Directory of Open Access Journals (Sweden)

    Darmayanti Dian Suryani

    2014-12-01

    Full Text Available Gigi kaninus sangat penting untuk estetika dan fungsi mastikasi seseorang. Impaksi gigi adalah gagalnya gigi untuk muncul ke dalam lengkung gigi yang dapat disebabkan karena kekurangan ruang, adanya sesuatu yang menghalangi jalur erupsi gigi atau karena faktor keturunan. Prevalensi impaks gigi kaninus maksila adalah 0,9-2,2%, sedangkan impaksi gigi kaninus mandibula lebih jarang terjadi. Alternatif perawatan gigi impaksi kaninus maksila adalah operasi exposure dan diikuti dengan kekuatan ortodontik untuk membantu erupsi dengan alat cekat ortodontik. Tujuan dari perawatan adalah untuk koreksi malrelasi dan malposisi gigi geligi, khususnya koreksi gigi kaninus impaksi menggunakan teknik Begg. Pasien laki-laki, 19 tahun, gigi sangat berjejal, gigi kaninus kanan kiri rahang atas dan gigi kaninus kanan rahang bawah impaksi, kelas I, deep overbite, overjet 3 mm dan overbite 8,8 mm. Perawatan dilakukan dengan menggunakan alat cekat Begg dengan tanpa pencabutan. Operasi exposure dilakukan untuk membuka gigi kaninus kanan kiri atas yang impaksi yang diikuti perekatan braket ortodontik. Kawat busur multiloop, anchorage bend dan elastik intermaksiler klas II digunakan pada tahap leveling dan unraveling. Dalam waktu 14 bulan,overbite terkoreksi, gigi kaninus kanan kiri atas sudah erupsi, overjet 3,00 mm, overbite 3,00 mm. Saat ini perawatan masih berlangsung pada tahap leveling dan unraveling untuk koreksi kaninus yang impaksi. Perawatan maloklusi angle klas I dengan berjejal dan impaksi kaninus maksila dapat dilakukan dengan operasi exposure gigi kaninus impaksi diikuti alat cekat Begg.   Orthodontic Treatment of Class I Malocclussion with Canine Impaction Using Begg Fixed Appliance. Canine is very important for aesthetic and masticatory function. Impaction refers to a failure of tooth to presence into the dental arch, usually due to either space deficiencies, the presence of an entity blocking the path of tooth eruption or due

  19. A Clinical Evaluation of Three Force Delivery Systems in Stage II of the Begg Technique

    Directory of Open Access Journals (Sweden)

    Vincy Antony Margaret

    2013-01-01

    Materials and methods: The present study was designed to compare the rates of retraction and anchorage loss between elastics, elastomeric chains and nickel-titanium (NiTi closed coil springs, using a continuous archwire system with the Begg light wire differential force technique. Results: The rate of canine retraction was faster by 0.6 mm per month with the NiTi closed coil spring compared to elastics and elastomeric chains. The NiTi closed coil springs produced more rapid rate of canine retraction but they also produced the greatest amount of anchorage loss.

  20. Kekuatan Geser Semen Ionomer Kaca Modifikasi Sebagai Pelekat Braket Begg Logam Dengan dan Tanpa Etsa

    Directory of Open Access Journals (Sweden)

    Dyah Karunia

    2015-10-01

    Full Text Available The adhesive of composite resin has been used for direct bonding of a bracket system of bracket fixed orthodontic treatment by etching. The disadvantage of etching is enamel loss and difficult procedure. Modified glass ionomer cement has been suggested as a bracket bonding system without etching. The chemical bonding without etching can reduce enamel loss and make the procedure more efficient. The purpose of this study was to determine the shear bond strength of modified glass ionomer cement as metal Begg bracket bonding system with and without etching. The subject of this study consisted of two groups which had 15 intact extracted permanent human upper bicuspids for each group. Group I was etched with ortho phosphate acid (37% for 20 seconds and bonded with modified glass ionomer cement. Group II was untreated and bonded with the same adhesive. The shear bond strength was measured with Pearson Pankee Equipment, and bond failure location was observed under stereo microscope. To differentiate the effects with and without etching, t test was performed, while to observe the location of bond failures, chi-square test was conducted. The results of this study indicated that the shear bond strength of modified glass ionomer cement as bonding system metal Begg Brackets with etching was significantly higher (p<0.001 than without etching. Without etching, bond failure occurred between enamel and bonding agent. With etching, the bond failure was mostly found within the adhesive.

  1. LISA Pathfinder: A Mission Status

    Science.gov (United States)

    Hewitson, Martin; LISA Pathfinder Team Team

    2016-03-01

    On December 3rd at 04:04 UTC, The European Space Agency launched the LISA Pathfinder satellite on board a VEGA rocket from Kourou in French Guiana. After a series of orbit raising manoeuvres and a 2 month long transfer orbit, LISA Pathfinder arrived at L1. Following a period of commissioning, the science operations commenced at the start of March, beginning the demonstration of technologies and methodologies which pave the way for a future large-scale gravitational wave observatory in space. This talk will present the scientific goals of the mission, discuss the technologies being tested, elucidate the link to a future space-based observatory, such as LISA, and present preliminary results from the in-orbit operations and experiments.

  2. Improving the sensitivity of LISA

    International Nuclear Information System (INIS)

    Nayak, K Rajesh; Pai, A; Dhurandhar, S V; Vinet, J-Y

    2003-01-01

    It has been shown in several recent papers that the six Doppler data streams obtained from a triangular LISA configuration can be combined by appropriately delaying the data streams for cancelling the laser frequency noise. Raw laser noise is several orders of magnitude above the other noises and thus it is essential to bring it down to the level of other noises such as shot, acceleration, etc. A rigorous and systematic formalism using the powerful techniques of computational commutative algebra was developed, which generates in principle all the data combinations cancelling the laser frequency noise. The relevant data combinations form a first module of syzygies. In this paper, we use this formalism to advantage for optimizing the sensitivity of LISA by analysing the noise and signal covariance matrices. The signal covariance matrix is calculated for binaries whose frequency changes at most adiabatically and the signal is averaged over polarizations and directions. We then present the extremal SNR curves for all the data combinations in the module. They correspond to the eigenvectors of the noise and signal covariance matrices. A LISA 'network' SNR is also computed by combining the outputs of the eigenvectors. We show that substantial gains in sensitivity can be obtained by employing these strategies. The maximum SNR curve can yield an improvement up to 70% over the Michelson, mainly at high frequencies, while the improvement using the network SNR ranges from 40% to over 100%. Finally, we describe a simple toy model, in which LISA rotates in a plane. In this analysis, we estimate the improvement in the LISA sensitivity, if one switches from one data combination to another as it rotates. Here the improvement in sensitivity, if one switches optimally over three cyclic data combinations of the eigenvector, is about 55% on average over the LISA bandwidth. The corresponding SNR improvement increases to 60%, if one maximizes over the module

  3. Molecular laser stabilization for LISA

    Science.gov (United States)

    Halloin, Hubert; Acef, Ouali; Argence, Berengere; Jeannin, Olivier; Prat, Pierre; de Vismes, Eden; Plagnol, Eric; Brillet, Alain; Mondin, Linda; Berthon, Jacques; Turazza, Oscar

    2017-11-01

    The expected performance of LISA relies on two main technical challenges: the ability for the spacecrafts to precisely follow the free-flying masses and the outstanding precision of the phase shift measurement. This latter constraint requires frequency stabilized lasers and efficient numerical algorithms to account for the redundant, delayed noise propagation, thus cancelling laser phase noise by many orders of magnitude (TDI methods). Recently involved in the technical developments for LISA, the goal of our team at APC (France) is to contribute on these two subjects: frequency reference for laser stabilization and benchtop simulation of the interferometer. In the present design of LISA, two stages of laser stabilization are used (not accounting for the "post-processed" TDI algorithm): laser pre-stabilization on a frequency reference and lock on the ultra stable distance between spacecrafts (arm-locking). While the foreseen (and deeply studied) laser reference consists of a Fabry-Perot cavity, other techniques may be suitable for LISA or future metrology missions. In particular, locking to a molecular reference (namely iodine in the case of the LISA Nd:YAG laser) is an interesting alternative. It offers the required performance with very good long-term stability (absolute frequency reference) though the reference can be slightly tuned to account for arm-locking. This technique is currently being investigated by our team and optimized for LISA (compactness, vacuum compatibility, ease of use and initialization, etc.). A collaboration with a French laboratory (the SYRTE) had been started aiming to study a second improved technique consisting in inserting the iodine cell in a Fabry-Perot cavity. Ongoing results and prospects to increase the performance of the system are presented in the present article.

  4. Laser modulator for LISA pathfinder

    Science.gov (United States)

    Voland, C.; Lund, G.; Coppoolse, W.; Crosby, P.; Stadler, M.; Kudielka, K.; Özkan, C.

    2017-11-01

    LISA Pathfinder is an ESA experiment to demonstrate the key technologies needed for the LISA mission to detect gravitational waves in space. The LISA Pathfinder spacecraft represents one arm of the LISA interferometer, containing an optical metrology system and two proof masses as inertial references for the drag-free control system. The LISA Pathfinder payload consists of two drag-free floating test masses located in the inertial sensors with their control electronics and an optical metrology subsystem. The optical metrology subsystem monitors the movement of both test masses relative to each other and to the spacecraft with very high sensitivity and resolution. This is achieved with a heterodyne Mach- Zehnder interferometer. This interferometer requires as input two coherent laser beams with a heterodyne frequency difference of a few kHz. To generate the two laser beams with a heterodyne frequency difference a Nd:YAG laser is used together with the Laser Modulator. The Nd:YAG laser generates a single coherent laser signal at a wavelength of 1064nm which is fibre coupled to the Laser Modulator. The Laser Modulator then generates the two optical beams with the required heterodyne frequency offset. In addition, the Laser Modulator is required to perform laser amplitude stabilization and optical path difference control for the two optical signals. The Laser Modulator consists of an optical unit - the LMU - and RF synthesiser, power amplification and control electronics. These electronics are all housed in the Laser Modulator Electronics (LME). The LMU has four primary functions: • Splitting of the input laser beam into two paths for later superposition in the interferometer. • Applying different frequency shifts to each of the beams. • Providing amplitude modulation control to each of the beams. • Providing active control of the optical path length difference between the two optical paths. The present paper describes the design and performance of the LMU

  5. Lisa Jevbratt / Lisa Jevbratt ; interv. Tilman Baumgärtel

    Index Scriptorium Estoniae

    Jevbratt, Lisa

    2006-01-01

    1967. a. Rootsis sündinud ja USA-s elavast kunstnikust Lisa Jevbrattist ning tema loomingust, 2000. a. jaanuaris tehtud meiliintervjuu kunstnikuga. L. Jevbratt kuulub rühmitusse C5, tema teosed keskenduvad pigem Interneti struktuurile kui selle sisule. Pikemalt võrguteosest "1:1" (2000), mille teemaks on IP-aadressid., lühidalt tööst "The Stillman Project" (1997), kunstniku galeriist "Non-Site"

  6. LISA Pathfinder author list

    International Nuclear Information System (INIS)

    2017-01-01

    , Italy 6 Department of Industrial Engineering, University of Trento, via Sommarive 9, 38123 Trento, and Trento Institute for Fundamental Physics and Application / INFN 7 Airbus Defence and Space, Claude-Dornier-Strasse, 88090 Immenstaad, Germany 8 European Space Technology Centre, European Space Agency, Keplerlaan 1, 2200 AG Noordwijk, The Netherlands 9 Dipartimento di Fisica, Università di Trento and Trento Institute for Fundamental Physics and Application / INFN, 38123 Povo, Trento, Italy 10 Department of Physics and Astronomy, University of Birmingham, Birmingham, UK 11 INAF Osservatorio Astronomico di Capodimonte, I-80131 Napoli, Italy and INFN sezione di Napoli, I-80126 Napoli, Italy 12 INFN - Sezione di Napoli, I-80126, Napoli, Italy 13 Airbus Defence and Space, Gunnels Wood Road, Stevenage, Hertfordshire, SG1 2AS, UK 14 Institut für Geophysik, ETH Zürich, Sonneggstrasse 5, CH-8092, Zürich, Switzerland 15 The UK Astronomy Technology Centre, Royal Observatory, Edinburgh, Blackford Hill, Edinburgh, EH9 3HJ, UK 16 Institut de Ciències de l’Espai (CSIC-IEEC), Campus UAB, Carrer de Can Magrans s/n, 08193 Cerdanyola del Vallès, Spain 17 DISPEA, Università di Urbino “Carlo Bo”, Via S. Chiara, 27 61029 Urbino/INFN, Italy 18 European Space Operations Centre, European Space Agency, 64293 Darmstadt, Germany 19 Physik Institut, Universität Zürich, Winterthurerstrasse 190, CH-8057 Zürich, Switzerland 20 SUPA, Institute for Gravitational Research, School of Physics and Astronomy, University of Glasgow, Glasgow, G12 8QQ, UK 21 Department d’Enginyeria Electrònica, Universitat Politècnica de Catalunya, 08034 Barcelona, Spain 22 CGS S.p.A, Compagnia Generale per lo Spazio, Via Gallarate, 150 - 20151 Milano, Italy 23 Gravitational Astrophysics Lab, NASA Goddard Space Flight Center, 8800 Greenbelt Road, Greenbelt, MD 20771 USA 24 Dipartimento di Fisica ed Astronomia, Università degli Studi di Firenze and INFN - Sezione di Firenze, I-50019 Firenze, Italy (paper)

  7. Micrometeorite Science with LISA Pathfinder

    Science.gov (United States)

    Pagane, Nicole; Thorpe, James Ira; Littenberg, Tyson; Littenberg, Tyson; Baker, John; Slutsky, Jacob; Hourihane, Sophie; LISA Pathfinder Team

    2018-01-01

    The primary objective of LISA Pathfinder (LPF) was to demonstrate drag-free control of test masses—along with the technology necessary to maintain the inertial motion—that LISA (Laser Interferometer Space Antenna) would later utilize as a space-based gravitational wave observatory. Due to the precise interferometry used during the mission, LPF could be employed as an accelerometer and used to detect micrometeorite impacts while in orbit about the Sun-Earth Lagrange Point L1. To infer micrometeorite impacts, the flight data was processed for event reconstruction to determine external acceleration of LPF; impact parameters were then estimated through a Markov-Chain Monte-Carlo (MCMC) tool via Bayesian analysis by fitting delta functions in the acceleration domain. As impact candidates were collected, a catalog of event data was curated with the reconstructed estimated parameters, among which were impact sky localizations that were later rotated into more intuitive reference frames. To infer the results of this dust modeling technique, current micrometeorite models were compared to the impact data. In the final reference frame common to the available micrometeorite models, the reconstructed impacts appear to cluster at (±90°, 0°)—where impacts prograde in this longitude-latitude frame were at (-90°, 0°), retrograde were (90°, 0°), and the sun was centered at the origin. The two available models used for comparison were of the Jupiter-family comets (JFC) and Halley-type comets (HTC), which clustered primarily around (±90°, 0°) and (0°, ±20°) respectively. This suggests that the JFC population seems to account for the majority of the impacts detected by LPF. The models’ expected rates given localization and velocity are currently being compared to the reconstructed data to further characterize the micrometeorite populations at L1. We will present our current analysis of this data set and discuss possibilities of extending such an analysis for LISA.

  8. LISA Pathfinder: OPD loop characterisation

    Science.gov (United States)

    Born, Michael; LPF Collaboration

    2017-05-01

    The optical metrology system (OMS) of the LISA Pathfinder mission is measuring the distance between two free-floating test masses with unprecedented precision. One of the four OMS heterodyne interferometers reads out the phase difference between the reference and the measurement laser beam. This phase from the reference interferometer is common to all other longitudinal interferometer read outs and therefore subtracted. In addition, the phase is fed back via the digital optical pathlength difference (OPD) control loop to keep it close to zero. Here, we analyse the loop parameters and compare them to on-ground measurement results.

  9. Observing a Gravitational Wave Background With Lisa

    National Research Council Canada - National Science Library

    Tinto, M; Armstrong, J; Estabrook, F

    2000-01-01

    ... formation of several observables. All are independent of lasers and frequency standard phase fluctuations, but have different couplings to gravitational waves and to the various LISA instrumental noises...

  10. Mona Lisa, lesbiahvid ja seksilaulud / Kaivo Kopli

    Index Scriptorium Estoniae

    Kopli, Kaivo

    2003-01-01

    Ameerika Teaduse Edendamise Assotsiatsiooni (AAA) konverentsil esitatud uusimatest teadusuuringutest. Artiklid: Mona Lisa naeratuse saladus paljastatud ; Lesbilised Jaapani makaagid seljatavad Darwini ; Linnud õpivad uusi laule uue partneri leidmiseks

  11. LISA Pathfinder instrument data analysis

    Science.gov (United States)

    Guzman, Felipe

    LISA Pathfinder (LPF) is an ESA-launched demonstration mission of key technologies required for the joint NASA-ESA gravitational wave observatory in space, LISA. As part of the LPF interferometry investigations, analytic models of noise sources and corresponding noise subtrac-tion techniques have been developed to correct for effects like the coupling of test mass jitter into displacement readout, and fluctuations of the laser frequency or optical pathlength difference. Ground testing of pre-flight hardware of the Optical Metrology Subsystem is currently ongoing at the Albert Einstein Institute Hannover. In collaboration with NASA Goddard Space Flight Center, the LPF mission data analysis tool LTPDA is being used to analyze the data product of these tests. Furthermore, the noise subtraction techniques and in-flight experiment runs for noise characterization are being defined as part of the mission experiment master plan. We will present the data analysis outcome of pre-flight hardware ground tests and possible noise subtraction strategies for in-flight instrument operations.

  12. Lisa Woodward | IDRC - International Development Research Centre

    International Development Research Centre (IDRC) Digital Library (Canada)

    Lisa Woodward is Special Advisor to the President. Before joining IDRC, Lisa held positions in strategic planning, performance measurement, evaluation, risk management, and policy development in federal organizations, including Fisheries and Oceans Canada, the Canadian International Development Agency, and the ...

  13. LISA: Probing the Universe with Gravitational Waves

    NARCIS (Netherlands)

    Prince, T.A.; Binetruy, P.; Centrella, J.; Finn, L.S.; Hogan, C.; Nelemans, G.A.; Phinney, E.S.; Schutz, B.; Team, L.I.S.

    2006-01-01

    LISA is a joint NASA/ESA space mission for detection and study of low-frequency gravitational waves in the band from 0.1 mHz to 0.1 Hz. The mission consists of three satellites separated by a nominal distance of 5 million kilometers, with precision metrology provided by laser ranging. LISA will

  14. Black Holes, Gravitational Waves, and LISA

    Science.gov (United States)

    Baker, John

    2009-01-01

    Binary black hole mergers are central to many key science objectives of the Laser Interferometer Space Antenna (LISA). For many systems the strongest part of the signal is only understood by numerical simulations. Gravitational wave emissions are understood by simulations of vacuum General Relativity (GR). I discuss numerical simulation results from the perspective of LISA's needs, with indications of work that remains to be done. Some exciting scientific opportunities associated with LISA observations would be greatly enhanced if prompt electromagnetic signature could be associated. I discuss simulations to explore this possibility. Numerical simulations are important now for clarifying LISA's science potential and planning the mission. We also consider how numerical simulations might be applied at the time of LISA's operation.

  15. Possible LISA Technology Applications for Other Missions

    Science.gov (United States)

    Livas, Jeffrey

    2018-01-01

    The Laser Interferometer Space Antenna (LISA) has been selected as the third large class mission launch opportunity of the Cosmic Visions Program by the European Space Agency (ESA). LISA science will explore a rich spectrum of astrophysical gravitational-wave sources expected at frequencies between 0.0001 and 0.1 Hz and complement the work of other observatories and missions, both space and ground-based, electromagnetic and non-electromagnetic. Similarly, LISA technology may find applications for other missions. This paper will describe the capabilities of some of the key technologies and discuss possible contributions to other missions.

  16. Perawatan Maloklusi Angle Klas I dengan Gigi Depan Crowding Berat dan Cross Bite Menggunakan Teknik Begg pada Pasien dengan Kebersihan Mulut Buruk

    Directory of Open Access Journals (Sweden)

    Sri Wahyuningsih

    2014-12-01

    Full Text Available Gigi depan crowding/berjejal parah dan cross bite adalah kasus yang sering dijumpai pada perawatan ortodontik. Gigi crowding dapat menyulitkan membersihkan mulut pada area gigi crowding sehingga dapat menyebabkan masalah periodontal. Salah satu keuntungan perawatan ortodontik cekat dengan teknik Begg adalah menghasilkan gaya yang ringan dalam megkoreksi gigi berjejal dan cross bite dapat memberikan kenyamanan pada pasien. Tujuan perawatan ini adalah untuk mengkoreksi gigi berjejal dan cross bite dalam waktu yang singkat menggunakan teknik Begg. Seorang pasien wanita umur 24 tahun dengan maloklusi Angle klas I dan skeletal klas III protrusif mandibula, gigi depan crowding berat dan cross bite, konstraksi lengkung pada kedua rahang, pergeseran median line rahang atas dan bawah disertai, gingivitis berat dan karies. Skaling, perawatan saluran akar dan pencabutan gigi non vital dilakukan sebelum perawatan ortodontik dilakukan. Koreksi dengan teknik Begg memerlukan waktu selama 6 bulan untuk mengkoreksi gigi crowding dan cross bite semuanya dalam waktu yang sama. Koreksi kasus gigi depan crowding berat dan cross bite disertai masalah periodontal dapat dilakukan dengan teknik Begg dalam waktu yang singkat dengan kemajuan yang bagus.   Treatment of Class I Angle Malocclusion with Severe Crowding and Crossbite of Anterior Teeth Using Begg Technique in Bad Oral Hygiene Patient. The severe crowding and cross bite of anterior teeth were very common type cases in orthodontic. Crowding teeth compromised the oral hygiene due to the difficulty in oral cleansing on the crowding area that cause periodontal problem. One of advantages of fixed orthodontic treatment using Begg technique produced the light forces in correcting crowding and cross bite could give convenience to patients. The purpose of this treatment is to correct crowding and cross bite in a short period of time using Begg technique. A 24 years old female patient with Class I Angle

  17. Lisa's Lemonade Stand: Exploring Algebraic Ideas.

    Science.gov (United States)

    Billings, Esther M. H.; Lakatos, Tracy

    2003-01-01

    Presents an activity, "Lisa's Lemonade Stand," that actively engages students in algebraic thinking as they analyze change by investigating relationships between variables and gain experience describing and representing these relationships graphically. (YDS)

  18. Optimizing the Earth-LISA 'rendezvous'

    International Nuclear Information System (INIS)

    De Marchi, Fabrizio; Pucacco, Giuseppe; Bassan, Massimo

    2012-01-01

    We present a general survey of heliocentric LISA orbits, hoping that it might help in the exercise of rescoping the mission. We try to semi-analytically optimize the orbital parameters in order to minimize the disturbances coming from the Earth-LISA interaction. In a set of numerical simulations, we include non-autonomous perturbations and provide an estimate of Doppler shift and breathing as a function of the trailing angle. (paper)

  19. Novel Payload Architectures for LISA

    Science.gov (United States)

    Johann, Ulrich A.; Gath, Peter F.; Holota, Wolfgang; Schulte, Hans Reiner; Weise, Dennis

    2006-11-01

    As part of the current LISA Mission Formulation Study, and based on prior internal investigations, Astrium Germany has defined and preliminary assessed novel payload architectures, potentially reducing overall complexity and improving budgets and costs. A promising concept is characterized by a single active inertial sensor attached to a single optical bench and serving both adjacent interferometer arms via two rigidly connected off-axis telescopes. The in-plane triangular constellation ``breathing angle'' compensation is accomplished by common telescope in-field of view pointing actuation of the transmit/received beams line of sight. A dedicated actuation mechanism located on the optical bench is required in addition to the on bench actuators for differential pointing of the transmit and receive direction perpendicular to the constellation plane. Both actuators operate in a sinusoidal yearly period. A technical challenge is the actuation mechanism pointing jitter and the monitoring and calibration of the laser phase walk which occurs while changing the optical path inside the optical assembly during re-pointing. Calibration or monitoring of instrument internal phase effects e.g. by a laser metrology truss derived from the existing interferometry is required. The architecture exploits in full the two-step interferometry (strap down) concept, separating functionally inter spacecraft and intra-spacecraft interferometry (reference mass laser metrology degrees of freedom sensing). The single test mass is maintained as cubic, but in free-fall in the lateral degrees of freedom within the constellation plane. Also the option of a completely free spherical test mass with full laser interferometer readout has been conceptually investigated. The spherical test mass would rotate slowly, and would be allowed to tumble. Imperfections in roundness and density would be calibrated from differential wave front sensing in a tetrahedral arrangement, supported by added attitude

  20. Cryptanalysis of MD2

    DEFF Research Database (Denmark)

    Knudsen, Lars Ramkilde; Mathiassen, John Erik; Muller, Frédéric

    2010-01-01

    This paper considers the hash function MD2 which was developed by Ron Rivest in 1989. Despite its age, MD2 has withstood cryptanalytic attacks until recently. This paper contains the state-of-the-art cryptanalytic results on MD2, in particular collision and preimage attacks on the full hash...

  1. Confusion noise from LISA capture sources

    International Nuclear Information System (INIS)

    Barack, Leor; Cutler, Curt

    2004-01-01

    Captures of compact objects (COs) by massive black holes (MBHs) in galactic nuclei will be an important source for LISA, the proposed space-based gravitational wave (GW) detector. However, a large fraction of captures will not be individually resolvable - either because they are too distant, have unfavorable orientation, or have too many years to go before final plunge - and so will constitute a source of 'confusion noise', obscuring other types of sources. In this paper we estimate the shape and overall magnitude of the GW background energy spectrum generated by CO captures. This energy spectrum immediately translates to a spectral density S h capt (f) for the amplitude of capture-generated GWs registered by LISA. The overall magnitude of S h capt (f) is linear in the CO capture rates, which are rather uncertain; therefore we present results for a plausible range of rates. S h capt (f) includes the contributions from both resolvable and unresolvable captures, and thus represents an upper limit on the confusion noise level. We then estimate what fraction of S h capt (f) is due to unresolvable sources and hence constitutes confusion noise. We find that almost all of the contribution to S h capt (f) coming from white dwarf and neutron star captures, and at least ∼30% of the contribution from black hole captures, is from sources that cannot be individually resolved. Nevertheless, we show that the impact of capture confusion noise on the total LISA noise curve ranges from insignificant to modest, depending on the rates. Capture rates at the high end of estimated ranges would raise LISA's overall (effective) noise level [fS h eff (f)] 1/2 by at most a factor ∼2 in the frequency range 1-10 mHz, where LISA is most sensitive. While this slightly elevated noise level would somewhat decrease LISA's sensitivity to other classes of sources, we argue that, overall, this would be a pleasant problem for LISA to have: It would also imply that detection rates for CO captures

  2. Free-flight experiments in LISA Pathfinder

    International Nuclear Information System (INIS)

    Armano, M; Audley, H; Born, M; Danzmann, K; Diepholz, I; Auger, G; Binetruy, P; Baird, J; Bortoluzzi, D; Brandt, N; Bursi, A; Caleno, M; Cavalleri, A; Cesarini, A; Dolesi, R; Ferroni, V; Cruise, M; Cutler, C; Dunbar, N; Ferraioli, L

    2015-01-01

    The LISA Pathfinder mission will demonstrate the technology of drag-free test masses for use as inertial references in future space-based gravitational wave detectors. To accomplish this, the Pathfinder spacecraft will perform drag-free flight about a test mass while measuring the acceleration of this primary test mass relative to a second reference test mass. Because the reference test mass is contained within the same spacecraft, it is necessary to apply forces on it to maintain its position and attitude relative to the spacecraft. These forces are a potential source of acceleration noise in the LISA Pathfinder system that are not present in the full LISA configuration. While LISA Pathfinder has been designed to meet it's primary mission requirements in the presence of this noise, recent estimates suggest that the on-orbit performance may be limited by this ‘suspension noise’. The drift-mode or free-flight experiments provide an opportunity to mitigate this noise source and further characterize the underlying disturbances that are of interest to the designers of LISA-like instruments. This article provides a high-level overview of these experiments and the methods under development to analyze the resulting data. (paper)

  3. Data analysis for the LISA Technology Package

    International Nuclear Information System (INIS)

    Hewitson, M; Danzmann, K; Diepholz, I; GarcIa, A; Armano, M; Fauste, J; Benedetti, M; Bogenstahl, J; Bortoluzzi, D; Bosetti, P; Cristofolini, I; Brandt, N; Cavalleri, A; Ciani, G; Dolesi, R; Ferraioli, L; Cruise, M; Fertin, D; GarcIa, C; Fichter, W

    2009-01-01

    The LISA Technology Package (LTP) on board the LISA Pathfinder mission aims to demonstrate some key concepts for LISA which cannot be tested on ground. The mission consists of a series of preplanned experimental runs. The data analysis for each experiment must be designed in advance of the mission. During the mission, the analysis must be carried out promptly so that the results can be fed forward into subsequent experiments. As such a robust and flexible data analysis environment needs to be put in place. Since this software is used during mission operations and effects the mission timeline, it must be very robust and tested to a high degree. This paper presents the requirements, design and implementation of the data analysis environment (LTPDA) that will be used for analysing the data from LTP. The use of the analysis software to perform mock data challenges (MDC) is also discussed, and some highlights from the first MDC are presented.

  4. Data analysis for the LISA Technology Package

    Energy Technology Data Exchange (ETDEWEB)

    Hewitson, M; Danzmann, K; Diepholz, I; GarcIa, A [Albert-Einstein-Institut, Max-Planck-Institut fuer Gravitationsphysik und Universitaet Hannover, 30167 Hannover (Germany); Armano, M; Fauste, J [European Space Agency, ESAC, Villanueva de la Canada, 28692 Madrid (Spain); Benedetti, M [Dipartimento di Ingegneria dei Materiali e Tecnologie Industriali, Universita di Trento and INFN, Gruppo Collegato di Trento, Mesiano, Trento (Italy); Bogenstahl, J [Department of Physics and Astronomy, University of Glasgow, Glasgow (United Kingdom); Bortoluzzi, D; Bosetti, P; Cristofolini, I [Dipartimento di Ingegneria Meccanica e Strutturale, Universita di Trento and INFN, Gruppo Collegato di Trento, Mesiano, Trento (Italy); Brandt, N [Astrium GmbH, 88039 Friedrichshafen (Germany); Cavalleri, A; Ciani, G; Dolesi, R; Ferraioli, L [Dipartimento di Fisica, Universita di Trento and INFN, Gruppo Collegato di Trento, 38050 Povo, Trento (Italy); Cruise, M [Department of Physics and Astronomy, University of Birmingham, Birmingham (United Kingdom); Fertin, D; GarcIa, C [European Space Agency, ESTEC, 2200 AG Noordwijk (Netherlands); Fichter, W, E-mail: martin.hewitson@aei.mpg.d [Institut fuer Flugmechanik und Flugregelung, 70569 Stuttgart (Germany)

    2009-05-07

    The LISA Technology Package (LTP) on board the LISA Pathfinder mission aims to demonstrate some key concepts for LISA which cannot be tested on ground. The mission consists of a series of preplanned experimental runs. The data analysis for each experiment must be designed in advance of the mission. During the mission, the analysis must be carried out promptly so that the results can be fed forward into subsequent experiments. As such a robust and flexible data analysis environment needs to be put in place. Since this software is used during mission operations and effects the mission timeline, it must be very robust and tested to a high degree. This paper presents the requirements, design and implementation of the data analysis environment (LTPDA) that will be used for analysing the data from LTP. The use of the analysis software to perform mock data challenges (MDC) is also discussed, and some highlights from the first MDC are presented.

  5. Reconstructing the dark sector interaction with LISA

    Energy Technology Data Exchange (ETDEWEB)

    Cai, Rong-Gen; Yang, Tao [CAS Key Laboratory of Theoretical Physics, Institute of Theoretical Physics, Chinese Academy of Sciences, P.O. Box 2735, Beijing 100190 (China); Tamanini, Nicola, E-mail: cairg@itp.ac.cn, E-mail: nicola.tamanini@cea.fr, E-mail: yangtao@itp.ac.cn [Institut de Physique Théorique, CEA-Saclay, CNRS UMR 3681, Université Paris-Saclay, F-91191 Gif-sur-Yvette (France)

    2017-05-01

    We perform a forecast analysis of the ability of the LISA space-based interferometer to reconstruct the dark sector interaction using gravitational wave standard sirens at high redshift. We employ Gaussian process methods to reconstruct the distance-redshift relation in a model independent way. We adopt simulated catalogues of standard sirens given by merging massive black hole binaries visible by LISA, with an electromagnetic counterpart detectable by future telescopes. The catalogues are based on three different astrophysical scenarios for the evolution of massive black hole mergers based on the semi-analytic model of E. Barausse, Mon. Not. Roy. Astron. Soc. 423 (2012) 2533. We first use these standard siren datasets to assess the potential of LISA in reconstructing a possible interaction between vacuum dark energy and dark matter. Then we combine the LISA cosmological data with supernovae data simulated for the Dark Energy Survey. We consider two scenarios distinguished by the time duration of the LISA mission: 5 and 10 years. Using only LISA standard siren data, the dark sector interaction can be well reconstructed from redshift z ∼1 to z ∼3 (for a 5 years mission) and z ∼1 up to z ∼5 (for a 10 years mission), though the reconstruction is inefficient at lower redshift. When combined with the DES datasets, the interaction is well reconstructed in the whole redshift region from 0 z ∼ to z ∼3 (5 yr) and z ∼0 to z ∼5 (10 yr), respectively. Massive black hole binary standard sirens can thus be used to constrain the dark sector interaction at redshift ranges not reachable by usual supernovae datasets which probe only the z ∼< 1.5 range. Gravitational wave standard sirens will not only constitute a complementary and alternative way, with respect to familiar electromagnetic observations, to probe the cosmic expansion, but will also provide new tests to constrain possible deviations from the standard ΛCDM dynamics, especially at high redshift.

  6. LISA Mission and System architectures and performances

    International Nuclear Information System (INIS)

    Gath, Peter F; Weise, Dennis; Schulte, Hans-Reiner; Johann, Ulrich

    2009-01-01

    In the context of the LISA Mission Formulation Study, the LISA System was studied in detail and a new baseline architecture for the whole mission was established. This new baseline is the result of trade-offs on both, mission and system level. The paper gives an overview of the different mission scenarios and configurations that were studied in connection with their corresponding advantages and disadvantages as well as performance estimates. Differences in the required technologies and their influence on the overall performance budgets are highlighted for all configurations. For the selected baseline concept, a more detailed description of the configuration is given and open issues in the technologies involved are discussed.

  7. LISA Mission and System architectures and performances

    Energy Technology Data Exchange (ETDEWEB)

    Gath, Peter F; Weise, Dennis; Schulte, Hans-Reiner; Johann, Ulrich, E-mail: peter.gath@astrium.eads.ne [Astrium GmbH Satellites, 88039 Friedrichshafen (Germany)

    2009-03-01

    In the context of the LISA Mission Formulation Study, the LISA System was studied in detail and a new baseline architecture for the whole mission was established. This new baseline is the result of trade-offs on both, mission and system level. The paper gives an overview of the different mission scenarios and configurations that were studied in connection with their corresponding advantages and disadvantages as well as performance estimates. Differences in the required technologies and their influence on the overall performance budgets are highlighted for all configurations. For the selected baseline concept, a more detailed description of the configuration is given and open issues in the technologies involved are discussed.

  8. Galactic binaries with eLISA

    OpenAIRE

    Nelemans, G.

    2013-01-01

    I review what eLISA will see from Galactic binaries -- double stars with orbital periods less than a few hours and white dwarf (or neutron star/black hole) components. I discuss the currently known binaries that are guaranteed (or verification) sources and explain why the expected total number of eLISA Galactic binaries is several thousand, even though there are large uncertainties in our knowledge of this population, in particular that of the interacting AM CVn systems. I very briefly sketch...

  9. Injector MD Days 2017

    CERN Document Server

    Rumolo, G

    2017-01-01

    The Injector Machine Development (MD) days 2017 were held on 23-24 March, 2017, at CERN with thefollowing main goals:Give a chance to the MD users to present their results and show the relevant progress made in 2016 onseveral fronts.Provide the MD users and the Operation (OP) crews with a general overview on the outcome and theimpact of all ongoing MD activities.Identify the open questions and consequently define - with priorities - a list of machine studies in theinjectors for 2017 (covering the operational beams, LHC Injectors Upgrade, High Luminosity LHC,Physics Beyond Colliders, other projects).Create the opportunity to collect and document the highlights of the 2016 MDs and define the perspectivesfor 2017.Discuss how to make best use of the MD time, in particular let the main MD user express their wishesand see whether/how OP teams can contribute to their fulfilment.

  10. Mona Lisa kuulsa naeratuse saladus leidis lahenduse / Johannes Saar

    Index Scriptorium Estoniae

    Saar, Johannes, 1965-

    2004-01-01

    Firenze kunstiajalooõpetaja Giuseppe Pallanti jõudis 25-aastase arhiivitöö tulemusena järeldusele, et Leonardo da Vinci Mona Lisa modelliks on siidikaupmehe Francesco del Giocondo abikaasa Lisa Gerardini

  11. The Mona Lisa of modern science.

    Science.gov (United States)

    Kemp, Martin

    2003-01-23

    No molecule in the history of science has reached the iconic status of the double helix of DNA. Its image has been imprinted on all aspects of society, from science, art, music, cinema, architecture and advertising. This review of the Mona Lisa of science examines the evolution of its form at the hands of both science and art.

  12. A noise simulator for eLISA: Migrating LISA Pathfinder knowledge to the eLISA mission

    OpenAIRE

    Armano, M.; Audley, H.; Auger, G.; Baird, J.; Binetruy, P.; Born, Michael; Bortoluzzi, D.; Brandt, N.; Bursi, A.; Caleno, M.; Cavalleri, A.; Cesarini, A.; Cruise, M.; Danzmann, Karsten; Diepholz, I.

    2015-01-01

    We present a new technical simulator for the eLISA mission, based on state space modeling techniques and developed in MATLAB. This simulator computes the coordinate and velocity over time of each body involved in the constellation, i.e. the spacecraft and its test masses, taking into account the different disturbances and actuations. This allows studying the contribution of instrumental noises and system imperfections on the residual acceleration applied on the TMs, the latter reflecting the ...

  13. Time-delay interferometry for LISA

    International Nuclear Information System (INIS)

    Tinto, Massimo; Estabrook, F.B.; Armstrong, J.W.

    2002-01-01

    LISA (Laser Interferometer Space Antenna) is a mission to detect and study low-frequency cosmic gravitational radiation through its influence on the phases or frequencies of laser beams exchanged between three remote spacecraft. We previously showed how, with lasers of identical frequencies on stationary spacecraft, the measurement of twelve time series of Doppler shifts could be combined to cancel exactly the phase noise of the lasers and the Doppler fluctuations due to noninertial motions of the six optical benches, while preserving gravitational wave signals. Here we generalize those results on gravitational wave detection with time-delay interferometry to the expected LISA instrument. The six lasers have different center frequencies (in the nominal LISA configuration these center frequencies may well differ by several hundred megahertz) and the distances between spacecraft pairs will change with time (these slowly varying orbital Doppler shifts are expected to be up to tens of megahertz). We develop time-delay data combinations which, as previously, preserve gravitational waves and exactly cancel the leading noise source (phase fluctuations of the six lasers); these data combinations then imply transfer functions for the remaining system noises. Using these, we plot frequency and phase power spectra for modeled system noises in the unequal Michelson combination X and the symmetric Sagnac combination ζ. Although optical bench noise can no longer be cancelled exactly, with the current LISA specifications it is suppressed to negligible levels. It is known that the presently anticipated laser center frequency differences and the orbital Doppler drifts introduce another source of phase noise, arising from the onboard oscillators required to track the photodetector fringes. For the presently planned mission, our analysis indeed demonstrates that noise from current-generation ultrastable oscillators would, if uncorrected, dominate the LISA noise budget. To meet the

  14. Identification of 253Md

    International Nuclear Information System (INIS)

    Kadkhodayan, B.; Czerwinski, K.R.; Kreek, S.A.; Hannink, N.J.; Gregorich, K.E.; Lee, D.M.; Nurmia, M.J.; Hoffman, D.C.; Hall, H.L.

    1992-01-01

    We have measured the half-life and production cross section of the new isotope 253 Md, produced via the 243 Am( 13 C,3n) reaction. Isolation of Md from other activities was accomplished using elution with ammonium α-hydroxyisobutyrate from a cation exchange resin column. Experiments were performed with different irradiation time intervals, but the chemical separation always began and ended at exactly the same length of time after the end of irradiation. All separations with the same irradation lengths were combined and analyzed for growth and decay of the 3.0-d 253 Fm daughter and 20.47-d 253 Es, granddaugther of 253 Md. The amount of 253 Es in each fraction depends on the length of each irradiation and the 253 Md half-life. An increase in the length of irradiation will cause a corresponding increase in the amount of the new isotope 253 Md and hence, in the amount of 253 Es produced, provided the length of irradiations are not very long compared to the half-life of 253 Md. In this way, the Md half-life was estimated to be about 6 minutes with a production cross section of the order of 50 nb. (orig.)

  15. LISA Sources in Milky Way Globular Clusters

    Science.gov (United States)

    Kremer, Kyle; Chatterjee, Sourav; Breivik, Katelyn; Rodriguez, Carl L.; Larson, Shane L.; Rasio, Frederic A.

    2018-05-01

    We explore the formation of double-compact-object binaries in Milky Way (MW) globular clusters (GCs) that may be detectable by the Laser Interferometer Space Antenna (LISA). We use a set of 137 fully evolved GC models that, overall, effectively match the properties of the observed GCs in the MW. We estimate that, in total, the MW GCs contain ˜21 sources that will be detectable by LISA. These detectable sources contain all combinations of black hole (BH), neutron star, and white dwarf components. We predict ˜7 of these sources will be BH-BH binaries. Furthermore, we show that some of these BH-BH binaries can have signal-to-noise ratios large enough to be detectable at the distance of the Andromeda galaxy or even the Virgo cluster.

  16. Weak-light phase locking for LISA

    International Nuclear Information System (INIS)

    McNamara, Paul W

    2005-01-01

    The long armlengths of the LISA interferometer, and the finite aperture of the telescope, lead to an optical power attenuation of ∼10 -10 of the transmitted to received light. Simple reflection at the end of the arm is therefore not an optimum interferometric design. Instead, a local laser is offset phase locked to the weak incoming beam, transferring the phase information of the incoming to the outgoing light. This paper reports on an experiment to characterize a weak-light phase-locking scheme suitable for LISA in which a diode-pumped, Nd:YAG, non-planar ring oscillator (NPRO) is offset phase locked to a low-power (13 pW) frequency stabilized master NPRO. Preliminary results of the relative phase noise of the slave laser shows shot noise limited performance above 0.4 Hz. Excess noise is observed at lower frequencies, most probably due to thermal effects in the optical arrangement and phase-sensing electronics

  17. Data Analysis for the LISA Pathfinder Mission

    Science.gov (United States)

    Thorpe, James Ira

    2009-01-01

    The LTP (LISA Technology Package) is the core part of the Laser Interferometer Space Antenna (LISA) Pathfinder mission. The main goal of the mission is to study the sources of any disturbances that perturb the motion of the freely-falling test masses from their geodesic trajectories as well as 10 test various technologies needed for LISA. The LTP experiment is designed as a sequence of experimental runs in which the performance of the instrument is studied and characterized under different operating conditions. In order to best optimize subsequent experimental runs, each run must be promptly analysed to ensure that the following ones make best use of the available knowledge of the instrument ' In order to do this, all analyses must be designed and tested in advance of the mission and have sufficient built-in flexibility to account for unexpected results or behaviour. To support this activity, a robust and flexible data analysis software package is also required. This poster presents two of the main components that make up the data analysis effort: the data analysis software and the mock-data challenges used to validate analysis procedures and experiment designs.

  18. Muscular Dystrophy (MD)

    Science.gov (United States)

    ... patients may need assisted ventilation to treat respiratory muscle weakness and a pacemaker for cardiac abnormalities. View Full Treatment Information Definition The muscular dystrophies (MD) are a group of more than 30 ...

  19. LISA and LISA PathFinder, the endeavour to detect low frequency GWs

    Energy Technology Data Exchange (ETDEWEB)

    Araujo, H [Blackett Laboratory, Imperial College London, Prince Consort Road, London SW7 2BW (United Kingdom); Boatella, C [Institut d' Estudis Espacials de Catalunya (IEEC), Edifici Nexus, Gran Capita 2-4, 08034 Barcelona (Spain); Chmeissani, M [Institut de Fisica d' Altes Energies (IFAE), Edifici C, Universitat Autonoma de Barcelona, 08193 Bellaterra (Barcelona) (Spain); Conchillo, A [Institut d' Estudis Espacials de Catalunya (IEEC), Edifici Nexus, Gran Capita 2-4, 08034 Barcelona (Spain); Garcia-Berro, E [Institut d' Estudis Espacials de Catalunya (IEEC), Edifici Nexus, Gran Capita 2-4, 08034 Barcelona (Spain); Grimani, C [Universita degli Studi di Urbino, and INFN Florence, Istituto di Fisica, Via Santa Chiara 27, 61029 Urbino (Italy); Hajdas, W [Department of Particles and Matter, Paul Scherrer Institut, ODRA 120, 5232 Villigen (Switzerland); Lobo, A [Institut d' Estudis Espacials de Catalunya (IEEC), Edifici Nexus, Gran Capita 2-4, 08034 Barcelona (Spain); Martinez, L [AtIpic, Parc Tecnologic del Valles, 08290 Cerdanyola del Valles, Barcelona (Spain); Nofrarias, M [Institut d' Estudis Espacials de Catalunya (IEEC), Edifici Nexus, Gran Capita 2-4, 08034 Barcelona (Spain); Ortega, J A [Institut d' Estudis Espacials de Catalunya (IEEC), Edifici Nexus, Gran Capita 2-4, 08034 Barcelona (Spain); Puigdengoles, C [Institut de Fisica d' Altes Energies (IFAE), Edifici C, Universitat Autonoma de Barcelona, 08193 Bellaterra (Barcelona) (Spain); Ramos-Castro, J [Departament d' Enginyeria Electronica, UPC, Campus Nord, Edif. C4, Jordi Girona 1-3, 08034 Barcelona (Spain); Sanjuan, J [Institut d' Estudis Espacials de Catalunya (IEEC), Edifici Nexus, Gran Capita 2-4, 08034 Barcelona (Spain); Wass, P [Blackett Laboratory, Imperial College London, Prince Consort Road, London SW7 2BW (United Kingdom); Xirgu, X [Institut d' Estudis Espacials de Catalunya (IEEC), Edifici Nexus, Gran Capita 2-4, 08034 Barcelona (Spain)

    2007-05-15

    This is a review about LISA and its technology demonstrator, LISAPathFinder. We first describe the conceptual problems which need to be overcome in order to set up a working interferometric detector of low frequency Gravitational Waves (GW), then summarise the solutions to them as currently conceived by the LISA mission team. This will show that some of these solutions require new technological abilities which are still under development, and which need proper test before being fully implemented. LISAPathFinder (LPF) is the the testbed for such technologies. The final part of the paper will address the ideas and concepts behind the PathFinder as well as their impact on LISA.

  20. LISA and LISA PathFinder, the endeavour to detect low frequency GWs

    International Nuclear Information System (INIS)

    Araujo, H; Boatella, C; Chmeissani, M; Conchillo, A; Garcia-Berro, E; Grimani, C; Hajdas, W; Lobo, A; Martinez, L; Nofrarias, M; Ortega, J A; Puigdengoles, C; Ramos-Castro, J; Sanjuan, J; Wass, P; Xirgu, X

    2007-01-01

    This is a review about LISA and its technology demonstrator, LISAPathFinder. We first describe the conceptual problems which need to be overcome in order to set up a working interferometric detector of low frequency Gravitational Waves (GW), then summarise the solutions to them as currently conceived by the LISA mission team. This will show that some of these solutions require new technological abilities which are still under development, and which need proper test before being fully implemented. LISAPathFinder (LPF) is the the testbed for such technologies. The final part of the paper will address the ideas and concepts behind the PathFinder as well as their impact on LISA

  1. Ground-based self-gravity tests for LISA Pathfinder and LISA

    International Nuclear Information System (INIS)

    Trenkel, C; Warren, C; Wealthy, D

    2009-01-01

    Gravitational coupling between the free-falling test masses and the surrounding spacecraft is one of the dominant noise sources for both LISA Pathfinder and LISA. At present, there are no plans to verify any of the self-gravity requirements by test, on the ground. Here, we explore the possibilities of conducting such tests, using a customised torsion balance. We discuss the main sources of systematic and statistical uncertainty present in such a set-up. Our preliminary assessment indicates that the sensitivity is sufficient to carry out meaningful self-gravity tests.

  2. Data analysis and source modelling for LISA

    International Nuclear Information System (INIS)

    Shang, Yu

    2014-01-01

    The gravitational waves are one of the most important predictions in general relativity. Besides of the directly proof of the existence of GWs, there are already several ground based detectors (such as LIGO, GEO, etc) and the planed future space mission (such as: LISA) which are aim to detect the GWs directly. GW contain a large amount of information of its source, extracting these information can help us dig out the physical property of the source, even open a new window for understanding the Universe. Hence, GW data analysis will be a challenging task in seeking the GWs. In this thesis, I present two works about the data analysis for LISA. In the first work, we introduce an extended multimodal genetic algorithm which utilizes the properties of the signal and the detector response function to analyze the data from the third round of mock LISA data challenge. We have found all five sources present in the data and recovered the coalescence time, chirp mass, mass ratio and sky location with reasonable accuracy. As for the orbital angular momentum and two spins of the Black Holes, we have found a large number of widely separated modes in the parameter space with similar maximum likelihood values. The performance of this method is comparable, if not better, to already existing algorithms. In the second work, we introduce an new phenomenological waveform model for the extreme mass ratio inspiral system. This waveform consists of a set of harmonics with constant amplitude and slowly evolving phase which we decompose in a Taylor series. We use these phenomenological templates to detect the signal in the simulated data, and then, assuming a particular EMRI model, estimate the physical parameters of the binary with high precision. The results show that our phenomenological waveform is very feasible in the data analysis of EMRI signal.

  3. Performance of arm locking in LISA

    International Nuclear Information System (INIS)

    McKenzie, Kirk; Spero, Robert E.; Shaddock, Daniel A.

    2009-01-01

    For the Laser Interferometer Space Antenna (LISA) to reach its design sensitivity, the coupling of the free-running laser frequency noise to the signal readout must be reduced by more than 14 orders of magnitude. One technique employed to reduce the laser frequency noise will be arm locking, where the laser frequency is locked to the LISA arm length. In this paper we detail an implementation of arm locking. We investigate orbital effects (changing arm lengths and Doppler frequencies), the impact of errors in the Doppler knowledge that can cause pulling of the laser frequency, and the noise limit of arm locking. Laser frequency pulling is examined in two regimes: at lock acquisition and in steady state. The noise performance of arm locking is calculated with the inclusion of the dominant expected noise sources: ultrastable oscillator (clock) noise, spacecraft motion, and shot noise. We find that clock noise and spacecraft motion limit the performance of dual arm locking in the LISA science band. Studying these issues reveals that although dual arm locking [A. Sutton and D. A. Shaddock, Phys. Rev. D 78, 082001 (2008)] has advantages over single (or common) arm locking in terms of allowing high gain, it has disadvantages in both laser frequency pulling and noise performance. We address this by proposing a modification to the dual arm-locking sensor, a hybrid of common and dual arm-locking sensors. This modified dual arm-locking sensor has the laser frequency pulling characteristics and low-frequency noise coupling of common arm locking, but retains the control system advantages of dual arm locking. We present a detailed design of an arm-locking controller and perform an analysis of the expected performance when used with and without laser prestabilization. We observe that the sensor phase changes beneficially near unity-gain frequencies of the arm-locking controller, allowing a factor of 10 more gain than previously believed, without degrading stability. With a time

  4. The LISA Pathfinder DMU and Radiation Monitor

    Energy Technology Data Exchange (ETDEWEB)

    Canizares, P; Conchillo, A; Gesa, L; Lloro, I; Lobo, A; Mateos, I; Sopuerta, Carlos F [Institut de Ciencies de l' Espai, CSIC, Facultat de Ciencies, Torre C5 parell, 08193 Bellaterra (Spain); Chmeissani, M [Institut de Fisica d' Altes Energies (IFAE), Edifici CN, UAB Campus, 08193 Bellaterra (Spain); Diaz-Aguilo, M; GarcIa-Berro, E; Gibert, F [Institut d' Estudis Espacials de Catalunya (IEEC), Edifici Nexus, Gran Capita 2-4, 08034 Barcelona (Spain); Grimani, C [Universita degli Studi di Urbino, MFI Department, Via Santa Chiara 27, 61029 Urbino, and INFN Florence (Italy); Nofrarias, M [Max-Planck-Institut fuer Gravitationsphysik (Albert-Einstein-Institut), Callinstrasse 38, D-30167 Hannover (Germany); Ramos-Castro, J [Departament d' Enginyeria Electronica, UPC, Campus Nord, Edifici C4, Jordi Girona 1-3, 08034 Barcelona (Spain); Sanjuan, J [Department of Physics, University of Florida, NPB-22258 PO Box 118 440, Gainesville, FL 32611-8440 (United States); Araujo, H M; Wass, P, E-mail: lobo@ieec.fcr.es [High Energy Physics Blackett Laboratory, Prince Consort Road, Imperial College London, London SW7 2BW (United Kingdom)

    2011-05-07

    The LISA Pathfinder DMU (Data Management Unit) flight model was formally accepted by ESA and ASD on 11 February 2010, after all hardware and software tests had been successfully completed. The diagnostics items are scheduled to be delivered by the end of 2010. In this paper, we review the requirements and performance of this instrumentation, specially focusing on the Radiation Monitor and the DMU, as well as the status of their programmed use during mission operations, on which work is ongoing at the time of writing.

  5. LISA Beyond Einstein: From the Big Bang to Black Holes. LISA Technology Development at GSFC

    Science.gov (United States)

    Thorpe, James Ira

    2008-01-01

    This viewgraph presentation reviews the work that has been ongoing at the Goddard Space Flight Center (GSFC) in the development of the technology to be used in the Laser Interferometer Space Antenna (LISA) spacecrafts. The prime focus of LISA technology development efforts at NASA/GSFC has been in LISA interferometry. Specifically efforts have been made in the area of laser frequency noise mitigation. Laser frequency noise is addressed through a combination of stabilization and common-mode rejection. Current plans call for two stages of stabilization, pre-stabilization to a local frequency reference and further stabilization using the constellation as a frequency reference. In order for these techniques to be used simultaneously, the pre-stabilization step must provide an adjustable frequency offset. This presentation reports on a modification to the standard modulation/demodulation technique used to stabilize to optical cavities that generates a frequency-tunable reference from a fixed length cavity. This technique requires no modifications to the cavity itself and only minor modifications to the components. The measured noise performance and dynamic range of the laboratory prototype meet the LISA requirements.

  6. Optical testbed for the LISA phasemeter

    International Nuclear Information System (INIS)

    Schwarze, T S; Fernández Barranco, G; Penkert, D; Gerberding, O; Heinzel, G; Danzmann, K

    2016-01-01

    The planned spaceborne gravitational wave detector LISA will allow the detection of gravitational waves at frequencies between 0.1 mHz and 1 Hz. A breadboard model for the metrology system aka the phasemeter was developed in the scope of an ESA technology development project by a collaboration between the Albert Einstein Institute, the Technical University of Denmark and the Danish industry partner Axcon Aps. It in particular provides the electronic readout of the main interferometer phases besides auxiliary functions. These include clock noise transfer, ADC pilot tone correction, inter-satellite ranging and data transfer. Besides in LISA, the phasemeter can also be applied in future satellite geodesy missions. Here we show the planning and advances in the implementation of an optical testbed for the full metrology chain. It is based on an ultra-stable hexagonal optical bench. This bench allows the generation of three unequal heterodyne beatnotes with a zero phase combination, thus providing the possibility to probe the phase readout for non-linearities in an optical three signal test. Additionally, the utilization of three independent phasemeters will allow the testing of the auxiliary functions. Once working, components can individually be replaced with flight-qualified hardware in this setup. (paper)

  7. Optical testbed for the LISA phasemeter

    Science.gov (United States)

    Schwarze, T. S.; Fernández Barranco, G.; Penkert, D.; Gerberding, O.; Heinzel, G.; Danzmann, K.

    2016-05-01

    The planned spaceborne gravitational wave detector LISA will allow the detection of gravitational waves at frequencies between 0.1 mHz and 1 Hz. A breadboard model for the metrology system aka the phasemeter was developed in the scope of an ESA technology development project by a collaboration between the Albert Einstein Institute, the Technical University of Denmark and the Danish industry partner Axcon Aps. It in particular provides the electronic readout of the main interferometer phases besides auxiliary functions. These include clock noise transfer, ADC pilot tone correction, inter-satellite ranging and data transfer. Besides in LISA, the phasemeter can also be applied in future satellite geodesy missions. Here we show the planning and advances in the implementation of an optical testbed for the full metrology chain. It is based on an ultra-stable hexagonal optical bench. This bench allows the generation of three unequal heterodyne beatnotes with a zero phase combination, thus providing the possibility to probe the phase readout for non-linearities in an optical three signal test. Additionally, the utilization of three independent phasemeters will allow the testing of the auxiliary functions. Once working, components can individually be replaced with flight-qualified hardware in this setup.

  8. Detection of Micrometeoroids with LISA Pathfinder

    Science.gov (United States)

    Thorpe, Ira; Littenberg, Tyson; Janchez, Diego; Baker, John; The LISA Pathfinder Team Team

    2017-01-01

    The LISA Pathfinder mission (LPF), a joint ESA/NASA technology demonstration mission currently operating at the Sun-Earth L1 point, contains the most precise accelerometry system ever flown. Analysis suggests that LPF should have sufficient sensitivity to detect impacts of small micrometeoroids and dust through their transfer of momentum to the spacecraft. Moreover, LPF's ability to fully resolve both the linear and angular momentum transfer in three dimensions allows a magnitude, direction, and location to be estimated for each impact. We present preliminary results from a systematic search of the LISA Pathfinder data for such impacts and discuss the prospects for using these and future results to inform models of the formation and evolution of dust populations in the inner solar system. These models have wide applicability to both pure and applied space science, ranging from the physics of planet formation and dynamics of minor Solar System bodies to estimates of the micrometeorite hazard for future spacecraft. 2017 NASA Science Innovation Fund.

  9. LISA as a dark energy probe

    International Nuclear Information System (INIS)

    Arun, K G; Mishra, Chandra Kant; Iyer, B R; Sinha, Siddhartha; Van Den Broeck, Chris; Sathyaprakash, B S

    2009-01-01

    Recently, it has been shown that the inclusion of higher signal harmonics in the inspiral signals of binary supermassive black holes (SMBH) leads to dramatic improvements in the parameter estimation with Laser Interferometer Space Antenna (LISA). In particular, the angular resolution becomes good enough to identify the host galaxy or galaxy cluster, in which case the redshift can be determined by electromagnetic means. The gravitational wave signal also provides the luminosity distance with high accuracy, and the relationship between this and the redshift depends sensitively on the cosmological parameters, such as the equation-of-state parameter w = p DE /ρ DE of dark energy. Using binary SMBH events at z < 1 with appropriate masses and orientations, one would be able to constrain w to within a few per cent. We show that, if the measured sky location is folded into the error analysis, the uncertainty on w goes down by an additional factor of 2-3, leaving weak lensing as the only limiting factor in using LISA as a dark energy probe.

  10. Interferometry for the LISA technology package LTP: an update

    International Nuclear Information System (INIS)

    Heinzel, G; Bogenstahl, J; Braxmaier, C; Danzmann, K; Garcia, A; Guzman, F; Hough, J; Hoyland, D; Jennrich, O; Killow, C; Robertson, D; Sodnik, Z; Steier, F; Ward, H; Wand, V

    2006-01-01

    This paper gives an update on the status of the LISA technology package (LTP) which is to be launched in 2009 by ESA as a technology demonstration mission for the spaceborne gravitational wave observatory LISA. The dominant noise source in the interferometer prototype has been investigated and improved such that it is now comfortably below its budget at all frequencies

  11. Fundamentals of the LISA stable flight formation

    International Nuclear Information System (INIS)

    Dhurandhar, S V; Nayak, K Rajesh; Koshti, S; Vinet, J-Y

    2005-01-01

    The joint NASA-ESA mission, LISA, relies crucially on the stability of the three-spacecraft constellation. Each of the spacecraft is in heliocentric orbit forming a stable triangle. In this paper we explicitly show with the help of the Clohessy-Wiltshire equations that any configuration of spacecraft lying in the planes making angles of ±60 0 with the ecliptic and given suitable initial velocities within the plane, can be made stable in the sense that the inter-spacecraft distances remain constant to first order in the dimensions of the configuration compared with the distance to the Sun. Such analysis would be useful in order to carry out theoretical studies on the optical links, simulators, etc

  12. Developing the MD Explorer

    Science.gov (United States)

    Howie, Philip V.

    1993-04-01

    The MD Explorer is an eight-seat twin-turbine engine helicopter which is being developed using integrated product definition (IPD) team methodology. New techniques include NOTAR antitorque system for directional control, a composite fuselage, an all-composite bearingless main rotor, and digital cockpit displays. Three-dimensional CAD models are the basis of the entire Explorer design. Solid models provide vendor with design clarification, removing much of the normal drawing interpretation errors.

  13. Charge Management in LISA Pathfinder: The Continuous Discharging Experiment

    Science.gov (United States)

    Ewing, Becca Elizabeth

    2018-01-01

    Test mass charging is a significant source of excess force and force noise in LISA Pathfinder (LPF). The planned design scheme for mitigation of charge induced force noise in LISA is a continuous discharge by UV light illumination. We report on analysis of a charge management experiment on-board LPF conducted during December 2016. We discuss the measurement of test mass charging noise with and without continuous UV illumination, in addition to the dynamic response in the continuous discharge scheme. Results of the continuous discharge system will be discussed for their application to operating LISA with lower test mass charge.

  14. Dual-Cylinder Laser Reference Cavities for LISA Project

    Data.gov (United States)

    National Aeronautics and Space Administration — "Summary: The Laser Interferometer Space Antenna (LISA) mission is under consideration by NASA and ESA as a joint mission to study gravitational wave signals from a...

  15. Gravitational Reference Sensor Front-End Electronics Simulator for LISA

    International Nuclear Information System (INIS)

    Meshksar, Neda; Ferraioli, Luigi; Mance, Davor; Zweifel, Peter; Giardini, Domenico; Ten Pierick, Jan

    2017-01-01

    At the ETH Zurich we are developing a modular simulator that provides a realistic simulation of the Front End Electronics (FEE) for LISA Gravitational Reference Sensor (GRS). It is based on the GRS FEE-simulator already implemented for LISA Pathfinder. It considers, in particular, the non-linearity and the critical details of hardware, such as the non-linear multiplicative noise caused by voltage reference instability, test mass charging and detailed actuation and sensing algorithms. We present the simulation modules, considering the above-mentioned features. Based on the ETH GRS FEE-simulator for LISA Pathfinder we aim to develop a modular simulator that provides a realistic simulation of GRS FEE for LISA. (paper)

  16. LISA and its in-flight test precursor SMART-2

    International Nuclear Information System (INIS)

    Vitale, S.; Bender, P.; Brillet, A.; Buchman, S.; Cavalleri, A.; Cerdonio, M.; Cruise, M.; Cutler, C.; Danzmann, K.; Dolesi, R.; Folkner, W.; Gianolio, A.; Jafry, Y.; Hasinger, G.; Heinzel, G.; Hogan, C.; Hueller, M.; Hough, J.; Phinney, S.; Prince, T.; Richstone, D.; Robertson, D.; Rodrigues, M.; Ruediger, A.; Sandford, M.; Schilling, R.; Shoemaker, D.; Schutz, B.; Stebbins, R.; Stubbs, C.; Sumner, T.; Thorne, K.; Tinto, M.; Touboul, P.; Ward, H.; Weber, W.; Winkler, W.

    2002-01-01

    LISA will be the first space-home gravitational wave observatory. It aims to detect gravitational waves in the 0.1 mHz/1 Hz range from sources including galactic binaries, super-massive black-hole binaries, capture of objects by super-massive black-holes and stochastic background. LISA is an ESA approved Cornerstone Mission foreseen as a joint ESA-NASA endeavour to be launched in 2010-11. The principle of operation of LISA is based on laser ranging of test-masses under pure geodesic motion. Achieving pure geodesic motion at the level requested for LISA, 3x10 -15 ms -2 /√Hz at 0.1 mHz, is considered a challenging technological objective. To reduce the risk, both ESA and NASA are pursuing an in-flight test of the relevant technology. The goal of the test is to demonstrate geodetic motion within one order of magnitude from the LISA performance. ESA has given this test as the primary goal of its technology dedicated mission SMART-2 with a launch in 2006. This paper describes the basics of LISA, its key technologies, and its in-flight precursor test on SMART-2

  17. A UV LED-based Charge Management System for LISA

    Science.gov (United States)

    Conklin, John W.; Chilton, Andrew; Olatunde, Taiwo Janet; Apple, Stephen; Parry, Samantha; Ciani, Giacomo; Wass, Peter; Mueller, Guido

    2018-01-01

    The Laser Interferometer Space Antenna (LISA) will be the first space instrument to observe gravitational waves in the millihertz frequency band. LISA consists of three Sun-orbiting spacecraft that form an equilateral triangle, with each side measuring 2.5 million kilometers in length. Each spacecraft houses two free-floating test masses, which are protected from all disturbing forces so that they follow pure geodesics in spacetime. A drag-free control system commands micronewton thrusters to force the spacecraft to fly in formation with the test masses and laser interferometers measure the minute variations in the distance, or light travel time, between these free-falling test masses caused by gravitational waves. The LISA observatory, with a planned launch in the early 2030s, is led by the European Space Agency with significant contributions from NASA. Recently, NASA has initiated strategic investments in key LISA technologies that will likely become U.S. flight hardware contributions to this ground-breaking mission. One of these payload elements is the Charge Management System (CMS), which controls the electric potential of the test masses relative to their housings to reduce spurious force noise acting on the test masses to below the required level. This talk, presented by University of Florida team that leads the CMS development, will describe this vital U.S. contribution to the LISA mission in the context of the envisioned LISA payload architecture and its in-flight sensitivity to gravitational waves.

  18. Verina Morton Jones, MD.

    Science.gov (United States)

    Rishworth, Susan K

    2012-01-01

    The purpose of this historical article is to demonstrate, as the biography of Verina Morton Jones, MD, is uncovered, the difficulties inherent in researching original source material on the lives of 19th- and early 20th-century African American physicians as well as the great benefits derived from doing this research. The procedures used include basic archival research and close examination of published materials about her in the past, in conjunction with oral history. Original correspondence from Dr Morton Jones to her niece and nephew is used to illustrate events in her life and the thoughts and attitudes she expressed. Some of these thoughts and attitudes reflect those current situations in which African Americans found themselves, and others are quite unique, no doubt owing to her privileged position in the African American community. The principle conclusions reached include the great benefits derived from doing this kind of research, as difficult and time-consuming as that may be, with the enhanced knowledge and appreciation of the heritage of African American physicians, and insights into American social history during this period.

  19. Harold E. Varmus, MD.

    Science.gov (United States)

    Varmus, H E

    1995-06-01

    On November 19, 1993, the Senate approved the nomination of Harold E. Varmus, MD, as Director of the National Institutes of Health (NIH). Varmus, who received the 1989 Nobel Prize in Medicine, brought unquestioned credentials as a scientist to the NIH. Despite his limited background as an administrator, Varmus has received high marks from most observers for improving the morale of NIH staffers and implementing streamlined procedures in the grant review process. His tenure has not been free of controversy, however. Many clinical researchers have long felt there is a bias in NIH study sections against patient-oriented research. A recent study sponsored by the Division of Research Grants confirmed the lower success rate of patient-oriented research proposals, but the outcome of these findings remains unclear. Faced with mounting political pressure for a balanced budget, and the resultant reduction of funding to many branches of government, Varmus has been a strong voice for non-targeted investigator initiated research. Interviewed in his office in Building One on the NIH campus in Bethesda, Maryland, Varmus discussed the state of patient oriented research, the evolving role of the NIH in supporting science, and just where the money to pay for it should be found.

  20. ADT fast losses MD

    CERN Document Server

    Priebe, A; Dehning, B; Redaelli, S; Salvachua Ferrando, BM; Sapinski, M; Solfaroli Camillocci, M; Valuch, D

    2013-01-01

    The fast beam losses in the order of 1 ms are expected to be a potential major luminosity limitation for higher beam energies after the LHC long shutdown (LS1). Therefore a Quench Test is planned in the winter 2013 to estimate the quench limit in this timescale and revise the current models. This experiment was devoted to determination the LHC Transverse Damper (ADT) as a system for fast losses induction. A non-standard operation of the ADT was used to develop the beam oscillation instead of suppressing them. The sign flip method had allowed us to create the fast losses within several LHC turns at 450 GeV during the previous test (26th March 2012). Thus, the ADT could be potentially used for the studies of the UFO ("Unidentied Falling Object") impact on the cold magnets. Verification of the system capability and investigations of the disturbed beam properties were the main objectives of this MD. During the experiment, the pilot bunches of proton beam were excited independently in the horizontal and vertical ...

  1. Distinguishing Between Formation Channels for Binary Black Holes with LISA

    Science.gov (United States)

    Breivik, Katelyn; Rodriguez, Carl L.; Larson, Shane L.; Kalogera, Vassiliki; Rasio, Frederic A.

    2017-01-01

    The recent detections of GW150914 and GW151226 imply an abundance of stellar-mass binary-black-hole mergers in the local universe. While ground-based gravitational-wave detectors are limited to observing the final moments before a binary merges, space-based detectors, such as the Laser Interferometer Space Antenna (LISA), can observe binaries at lower orbital frequencies where such systems may still encode information about their formation histories. In particular, the orbital eccentricity and mass of binary black holes in the LISA frequency band can be used together to discriminate between binaries formed in isolation in galactic fields and those formed in dense stellar environments such as globular clusters. In this letter, we explore the orbital eccentricity and mass of binary-black-hole populations as they evolve through the LISA frequency band. Overall we find that there are two distinct populations discernible by LISA. We show that up to ~90% of binaries formed either dynamically or in isolation have eccentricities measurable by LISA. Finally, we note how measured eccentricities of low-mass binary black holes evolved in isolation could provide detailed constraints on the physics of black-hole natal kicks and common-envelope evolution.

  2. LISA Pathfinder: hardware tests and their input to the mission

    Science.gov (United States)

    Audley, Heather

    The Laser Interferometer Space Antenna (LISA) is a joint ESA-NASA mission for the first space-borne gravitational wave detector. LISA aims to detect sources in the 0.1mHz to 1Hz range, which include supermassive black holes and galactic binary stars. Core technologies required for the LISA mission, including drag-free test mass control, picometre interferometry and micro-Newton thrusters, cannot be tested on-ground. Therefore, a precursor satellite, LISA Pathfinder, has been developed as a technology demonstration mission. The preparations for the LISA Pathfinder mission have reached an exciting stage. Tests of the engineering model of the optical metrology system have recently been completed at the Albert Einstein Institute, Hannover, and flight model tests are now underway. Significantly, they represent the first complete integration and testing of the space-qualified hardware and are the first tests on system level. The results and test procedures of these campaigns will be utilised directly in the ground-based flight hardware tests, and subsequently within in-flight operations. In addition, they allow valuable testing of the data analysis methods using the MatLab based LTP data analysis toolbox. This contribution presents an overview of the test campaigns calibration, control and perfor-mance results, focusing on the implications for the Experimental Master Plan which provides the basis for the in-flight operations and procedures.

  3. Accreting Double White Dwarf Binaries: Implications for LISA

    Energy Technology Data Exchange (ETDEWEB)

    Kremer, Kyle; Breivik, Katelyn; Larson, Shane L.; Kalogera, Vassiliki, E-mail: kremer@u.northwestern.edu, E-mail: katelyn.breivik@northwestern.edu, E-mail: vicky@northwestern.edu, E-mail: s.larson@northwestern.edu [Center for Interdisciplinary Exploration and Research in Astrophysics (CIERA), Department of Physics and Astronomy, Northwestern University 2145 Sheridan Road, Evanston, IL 60201 (United States)

    2017-09-10

    We explore the long-term evolution of mass-transferring white dwarf (WD) binaries undergoing both direct-impact and disk accretion and explore implications of such systems to gravitational-wave (GW) astronomy. We cover a broad range of initial component masses and show that these systems, the majority of which lie within the Laser Interferometer Space Antenna ( LISA ) sensitivity range, exhibit prominent negative orbital frequency evolution (chirp) for a significant fraction of their lifetimes. Using a galactic population synthesis, we predict ∼2700 of these systems will be observable with a negative chirp of 0.1 yr{sup −2} by a space-based GW detector like LISA . We also show that detections of mass-transferring double WD systems by LISA may provide astronomers with unique ways of probing the physics governing close compact object binaries.

  4. Accreting Double White Dwarf Binaries: Implications for LISA

    Science.gov (United States)

    Kremer, Kyle; Breivik, Katelyn; Larson, Shane L.; Kalogera, Vassiliki

    2017-09-01

    We explore the long-term evolution of mass-transferring white dwarf (WD) binaries undergoing both direct-impact and disk accretion and explore implications of such systems to gravitational-wave (GW) astronomy. We cover a broad range of initial component masses and show that these systems, the majority of which lie within the Laser Interferometer Space Antenna (LISA) sensitivity range, exhibit prominent negative orbital frequency evolution (chirp) for a significant fraction of their lifetimes. Using a galactic population synthesis, we predict ˜2700 of these systems will be observable with a negative chirp of 0.1 yr-2 by a space-based GW detector like LISA. We also show that detections of mass-transferring double WD systems by LISA may provide astronomers with unique ways of probing the physics governing close compact object binaries.

  5. Bayesian statistics for the calibration of the LISA Pathfinder experiment

    International Nuclear Information System (INIS)

    Armano, M; Freschi, M; Audley, H; Born, M; Danzmann, K; Diepholz, I; Auger, G; Binetruy, P; Bortoluzzi, D; Brandt, N; Fitzsimons, E; Bursi, A; Caleno, M; Cavalleri, A; Cesarini, A; Dolesi, R; Ferroni, V; Cruise, M; Dunbar, N; Ferraioli, L

    2015-01-01

    The main goal of LISA Pathfinder (LPF) mission is to estimate the acceleration noise models of the overall LISA Technology Package (LTP) experiment on-board. This will be of crucial importance for the future space-based Gravitational-Wave (GW) detectors, like eLISA. Here, we present the Bayesian analysis framework to process the planned system identification experiments designed for that purpose. In particular, we focus on the analysis strategies to predict the accuracy of the parameters that describe the system in all degrees of freedom. The data sets were generated during the latest operational simulations organised by the data analysis team and this work is part of the LTPDA Matlab toolbox. (paper)

  6. Accreting Double White Dwarf Binaries: Implications for LISA

    International Nuclear Information System (INIS)

    Kremer, Kyle; Breivik, Katelyn; Larson, Shane L.; Kalogera, Vassiliki

    2017-01-01

    We explore the long-term evolution of mass-transferring white dwarf (WD) binaries undergoing both direct-impact and disk accretion and explore implications of such systems to gravitational-wave (GW) astronomy. We cover a broad range of initial component masses and show that these systems, the majority of which lie within the Laser Interferometer Space Antenna ( LISA ) sensitivity range, exhibit prominent negative orbital frequency evolution (chirp) for a significant fraction of their lifetimes. Using a galactic population synthesis, we predict ∼2700 of these systems will be observable with a negative chirp of 0.1 yr −2 by a space-based GW detector like LISA . We also show that detections of mass-transferring double WD systems by LISA may provide astronomers with unique ways of probing the physics governing close compact object binaries.

  7. LISA package user guide. Part II: LISA (Long Term Isolation Safety Assessment) program description and user guide

    International Nuclear Information System (INIS)

    Prado, P.; Saltelli, A.; Homma, T.

    1992-01-01

    This manual is subdivided into three parts. In this second part, this document describes the LISA (Long term Isolation Safety Assessment) Code and its submodels. LISA is a tool for analysis of the safety of an underground disposal of nuclear waste. It has the capability to handle nuclide chain of arbitrary length and to evaluate the migration of nuclide through a geosphere medium composed of an arbitrary number of segments. LISA makes use of Monte Carlo methodology to evaluate the uncertainty in the quantity being assessed (eg dose) arising from the uncertainty in the model input parameters. In the present version LISA is equipped with a very simple source term submodel, a relatively complex geosphere and a simplified biosphere. The code is closely associated with its statistical pre-processor code (PREP), which generates the input Monte Carlo sample from the assigned parameter probability density functions and with its post-processor code (SPOP) which provides useful statistics on the output sample (uncertainty and sensitivity analysis). This report describes the general structure of LISA, its subroutines and submodels, the code input ant output files. It is intended to provide the user with enough information to know and run the code as well as the capacity to incorporate different submodels. 15 refs., 6 figs

  8. The Breadboard model of the LISA telescope assembly

    Science.gov (United States)

    Lucarelli, S.; Scheulen, D.; Kemper, D.; Sippel, R.; Verlaan, A.; Hogenhuis, H.; Ende, D.

    2017-11-01

    The primary goal of the LISA mission is the detection of gravitational waves from astronomical sources in a frequency range of 10-4 to 1 Hz. This requires operational stabilities in the picometer range as well as highly predictable mechanical distortions upon cooling down, outgassing in space, and gravity release. In March 2011 ESA announced a new way forward for the Lclass candidate missions, including LISA. ESA and the scientific community are now studying options for European-only missions that offer a significant reduction of the costs, while maintaining their core science objectives. In this context LISA has become the New Gravitational wave Observatory (NGO). Despite this reformulation, the need for dimensional stability in the picometer range remains valid, and ESA have continued the corresponding LISA Technology Development Activities (TDA's) also in view of NGO. In such frame Astrium GmbH and xperion (Friedrichshafen, Germany) have designed and manufactured an ultra-stable CFRP breadboard of the LISA telescope in order to experimentally demonstrate that the structure and the M1 & M2 mirror mounts are fulfilling the LISA requirements in the mission operational thermal environment. Suitable techniques to mount the telescope mirrors and to support the M1 & M2 mirrors have been developed, with the aim of measuring a system CTE of less than 10-7 K-1 during cooling down to -80°C. Additionally to the stringent mass and stiffness specifications, the required offset design makes the control of relative tilts and lateral displacements between the M1 and M2 mirrors particularly demanding. The thermo-elastic performance of the telescope assembly is going to be experimentally verified by TNO (Delft, The Netherlands) starting from the second half of 2012. This paper addresses challenges faced in the design phase, shows the resulting hardware and present first outcomes of the test campaign performed at TNO.

  9. Inference on inspiral signals using LISA MLDC data

    International Nuclear Information System (INIS)

    Roever, Christian; Stroeer, Alexander; Bloomer, Ed; Christensen, Nelson; Clark, James; Hendry, Martin; Messenger, Chris; Meyer, Renate; Pitkin, Matt; Toher, Jennifer; Umstaetter, Richard; Vecchio, Alberto; Veitch, John; Woan, Graham

    2007-01-01

    In this paper, we describe a Bayesian inference framework for the analysis of data obtained by LISA. We set up a model for binary inspiral signals as defined for the Mock LISA Data Challenge 1.2 (MLDC), and implemented a Markov chain Monte Carlo (MCMC) algorithm to facilitate exploration and integration of the posterior distribution over the nine-dimensional parameter space. Here, we present intermediate results showing how, using this method, information about the nine parameters can be extracted from the data

  10. LISA Pathfinder: Optical Metrology System monitoring during operations

    Science.gov (United States)

    Audley, Heather E.; LISA Pathfinder Collaboration

    2017-05-01

    The LISA Pathfinder (LPF) mission has demonstrated excellent performance. In addition to having surpassed the main mission goals, data has been collected from the various subsystems throughout the duration of the mission. This data is a valuable resource, both for a more complete understanding of the LPF satellite and the differential acceleration measurements, as well as for the design of the future Laser Interferometer Space Antenna (LISA) mission. Initial analysis of the Optical Metrology System (OMS) data was performed as part of daily system monitoring, and more in-depth analyses are ongoing. This contribution presents an overview of these activities along with an introduction to the OMS.

  11. E. Yiannopoulou on Lisa Blackman’s The Body.

    Directory of Open Access Journals (Sweden)

    2009-11-01

    Full Text Available Blackman, Lisa. The Body. Oxford and New York: Berg, 2008. 160 pp. “Is there anything natural about the human body?” (1. This is how Lisa Blackman begins her all too daunting task of reviewing and critically evaluating what has come to be known as “body theory” in the field of sociology. Carefully picking her way among numerous theories on the corporeal that have been produced across the humanities in the last twenty years, Blackman lays out her problematic from the start by asking to know w...

  12. 240 nm UV LEDs for LISA test mass charge control

    Science.gov (United States)

    Olatunde, Taiwo; Shelley, Ryan; Chilton, Andrew; Serra, Paul; Ciani, Giacomo; Mueller, Guido; Conklin, John

    2015-05-01

    Test Masses inside the LISA Gravitational Reference Sensor must maintain almost pure geodesic motion for gravitational waves to be successfully detected. LISA requires residual test mass accelerations below 3 fm/s2/√Hz at all frequencies between 0.1 and 3 mHz. One of the well-known noise sources is associated with the charges on the test masses which couple to stray electrical potentials and external electromagnetic fields. LISA Pathfinder will use Hg-discharge lamps emitting mostly around 254 nm to discharge the test masses via photoemission in its 2015/16 flight. A future LISA mission launched around 2030 will likely replace the lamps with newer UV-LEDs. Presented here is a preliminary study of the effectiveness of charge control using latest generation UV-LEDs which produce light at 240 nm with energy above the work function of pure Au. Their lower mass, better power efficiency and small size make them an ideal replacement for Hg lamps.

  13. 240 nm UV LEDs for LISA test mass charge control

    International Nuclear Information System (INIS)

    Olatunde, Taiwo; Shelley, Ryan; Chilton, Andrew; Serra, Paul; Ciani, Giacomo; Mueller, Guido; Conklin, John

    2015-01-01

    Test Masses inside the LISA Gravitational Reference Sensor must maintain almost pure geodesic motion for gravitational waves to be successfully detected. LISA requires residual test mass accelerations below 3 fm/s 2 /√Hz at all frequencies between 0.1 and 3 mHz. One of the well-known noise sources is associated with the charges on the test masses which couple to stray electrical potentials and external electromagnetic fields. LISA Pathfinder will use Hg-discharge lamps emitting mostly around 254 nm to discharge the test masses via photoemission in its 2015/16 flight. A future LISA mission launched around 2030 will likely replace the lamps with newer UV-LEDs. Presented here is a preliminary study of the effectiveness of charge control using latest generation UV-LEDs which produce light at 240 nm with energy above the work function of pure Au. Their lower mass, better power efficiency and small size make them an ideal replacement for Hg lamps. (paper)

  14. Multi-Messenger Astronomy: White Dwarf Binaries, LISA and GAIA

    Science.gov (United States)

    Bueno, Michael; Breivik, Katelyn; Larson, Shane L.

    2017-01-01

    The discovery of gravitational waves has ushered in a new era in astronomy. The low-frequency band covered by the future LISA detector provides unprecedented opportunities for multi-messenger astronomy. With the Global Astrometric Interferometer for Astrophysics (GAIA) mission, we expect to discover about 1,000 eclipsing binary systems composed of a WD and a main sequence star - a sizeable increase from the approximately 34 currently known binaries of this type. In advance of the first GAIA data release and the launch of LISA within the next decade, we used the Binary Stellar Evolution (BSE) code simulate the evolution of White Dwarf Binaries (WDB) in a fixed galaxy population of about 196,000 sources. Our goal is to assess the detectability of a WDB by LISA and GAIA using the parameters from our population synthesis, we calculate GW strength h, and apparent GAIA magnitude G. We can then use a scale factor to make a prediction of how many multi- messenger sources we expect to be detectable by both LISA and GAIA in a galaxy the size of the Milky Way. We create binaries 10 times to ensure randomness in distance assignment and average our results. We then determined whether or not astronomical chirp is the difference between the total chirp and the GW chirp. With Astronomical chirp and simulations of mass transfer and tides, we can gather more information about the internal astrophysics of stars in ultra-compact binary systems.

  15. Professor Lisa Aranson on JA Green (a pioonier artist photographer ...

    African Journals Online (AJOL)

    Jonathan Adagogo Green's photographic and artistic contributions working in his countryside, the Niger Delta of Nigeria is reviewed by Professor Lisa Aranson. Aranson in a public lecture presentation on the stand-point of art history thinks of J.A. Green as having operated in two worlds of which he is said to have initiated in ...

  16. 77 FR 56647 - Lisa Jean Sharp: Debarment Order

    Science.gov (United States)

    2012-09-13

    ... Act (the FD&C Act) permanently debarring Lisa Jean Sharp from providing services in any capacity to a...&C Act. Ms. Sharp was given notice of the proposed permanent debarment and an opportunity to request... drug product under the FD&C Act. The factual basis for this conviction is as follows: Ms. Sharp was the...

  17. Sensitivity and parameter-estimation precision for alternate LISA configurations

    International Nuclear Information System (INIS)

    Vallisneri, Michele; Crowder, Jeff; Tinto, Massimo

    2008-01-01

    We describe a simple framework to assess the LISA scientific performance (more specifically, its sensitivity and expected parameter-estimation precision for prescribed gravitational-wave signals) under the assumption of failure of one or two inter-spacecraft laser measurements (links) and of one to four intra-spacecraft laser measurements. We apply the framework to the simple case of measuring the LISA sensitivity to monochromatic circular binaries, and the LISA parameter-estimation precision for the gravitational-wave polarization angle of these systems. Compared to the six-link baseline configuration, the five-link case is characterized by a small loss in signal-to-noise ratio (SNR) in the high-frequency section of the LISA band; the four-link case shows a reduction by a factor of √2 at low frequencies, and by up to ∼2 at high frequencies. The uncertainty in the estimate of polarization, as computed in the Fisher-matrix formalism, also worsens when moving from six to five, and then to four links: this can be explained by the reduced SNR available in those configurations (except for observations shorter than three months, where five and six links do better than four even with the same SNR). In addition, we prove (for generic signals) that the SNR and Fisher matrix are invariant with respect to the choice of a basis of TDI observables; rather, they depend only on which inter-spacecraft and intra-spacecraft measurements are available

  18. GRS vs. OMS Calibration in LISA Pathfinder Data Analysis

    International Nuclear Information System (INIS)

    Meshksar, Neda; Ferraioli, Luigi; Mance, Davor; Zweifel, Peter; Giardini, Domenico; Ten Pierick, Jan

    2017-01-01

    On board LISA Pathfinder spacecraft the test mass displacement along the main measurement axis is sensed in two different ways: optically and electrostatically. We have monitored the relative calibration between the two measurements during the mission science phase. The trend sensitivity of the relative calibration has been computed for different physical parameters, such as temperature, magnetic field, test mass bias voltage and current. (paper)

  19. LISA data analysis using Markov chain Monte Carlo methods

    International Nuclear Information System (INIS)

    Cornish, Neil J.; Crowder, Jeff

    2005-01-01

    The Laser Interferometer Space Antenna (LISA) is expected to simultaneously detect many thousands of low-frequency gravitational wave signals. This presents a data analysis challenge that is very different to the one encountered in ground based gravitational wave astronomy. LISA data analysis requires the identification of individual signals from a data stream containing an unknown number of overlapping signals. Because of the signal overlaps, a global fit to all the signals has to be performed in order to avoid biasing the solution. However, performing such a global fit requires the exploration of an enormous parameter space with a dimension upwards of 50 000. Markov Chain Monte Carlo (MCMC) methods offer a very promising solution to the LISA data analysis problem. MCMC algorithms are able to efficiently explore large parameter spaces, simultaneously providing parameter estimates, error analysis, and even model selection. Here we present the first application of MCMC methods to simulated LISA data and demonstrate the great potential of the MCMC approach. Our implementation uses a generalized F-statistic to evaluate the likelihoods, and simulated annealing to speed convergence of the Markov chains. As a final step we supercool the chains to extract maximum likelihood estimates, and estimates of the Bayes factors for competing models. We find that the MCMC approach is able to correctly identify the number of signals present, extract the source parameters, and return error estimates consistent with Fisher information matrix predictions

  20. GRS vs. OMS Calibration in LISA Pathfinder Data Analysis

    Science.gov (United States)

    Meshksar, Neda; Ferraioli, Luigi; Mance, Davor; ten Pierick, Jan; Zweifel, Peter; Giardini, Domenico; ">LISA Pathfinder colaboration, LISA Pathfinder spacecraft the test mass displacement along the main measurement axis is sensed in two different ways: optically and electrostatically. We have monitored the relative calibration between the two measurements during the mission science phase. The trend sensitivity of the relative calibration has been computed for different physical parameters, such as temperature, magnetic field, test mass bias voltage and current.

  1. The Engineering of LISA Pathfinder – the quietest Laboratory ever flown in Space

    International Nuclear Information System (INIS)

    Trenkel, Christian; Wealthy, Dave; Dunbar, Neil; Warren, Carl; Schleicher, Alexander; Ziegler, Tobias; Brandt, Nico; Gerndt, Rüdiger

    2017-01-01

    We review the engineering approach adopted to ensure the required gravitational, magnetic, thermal and residual acceleration stability on-board LISA Pathfinder, and present the in-flight results that have been achieved. Arguably, this stability makes LISA Pathfinder the quietest laboratory ever flown in space. The implications for LISA are also discussed. (paper)

  2. Spontaneous fission of 259Md

    International Nuclear Information System (INIS)

    Hulet, E.K.; Wild, J.F.; Lougheed, R.W.; Baisden, P.A.; Landrum, J.H.; Dougan, R.J.; Mustafa, M.; Ghiorso, A.; Nitschke, J.M.

    1979-01-01

    The mass and kinetic energy distributions of fission fragments from the spontaneous fission of th newly discovered nuclide 259 Md were obtained. 259 Md was identified as the E. C. daughter of 259 No, and was found to decay entirely (> 95%) by spontaneous fission with a 95-min half-life. From the kinetic energies measured for 397 pairs of coincident fragments, a mass distribution was derived that is symmetric with sigma = 13 amu. 259 Md, together with 258 Fm and 259 Fm, form a select group of three nuclides whose mass division in spontaneous fission is highly symmetric. Unlike the total-kinetic-energy (TKE) distributions of 258 Fm and 259 Fm, which peak at approx. = to 240 MeV, this distribution for 259 Md is broad and is 50 MeV lower in energy. Analysis of the mass and energy distributions shows that events near mass symmetry also exhibit a broad TKE distribution, with one-third of the symmetric events having TKEs less than 200 MeV. The associated of low TKEs with symmetric mass division in the fission of very heavy actinides is anomalous and inconsistent with theories based upon the emergence of fragment shells near the scission point. Either three-body fragmentation or peculiar fragment shapes are assumed as the cause for the large consumption of Coulomb energy observed for a significant fraction of symmetric fissions in 259 Md. 6 figures

  3. Programme [11. international LISA symposium, Zurich (Switzerland), 5-9 September 2016

    International Nuclear Information System (INIS)

    2017-01-01

    Monday, 5th of September 2016 Chair: M. Colpi S. Vitale The LTP experiment on LISA Pathfinder and its first results K. Dooley Advanced LIGO: news from the dark universe B. Schutz LIGOs Black Holes and Science in the LISA Era P. McNamara LISA Pathfinder: First steps to observing gravitational waves from space M. Hewitson In-flight Performance of the Optical Metrology System on LISA Pathfinder W. Weber Physical model of the LISA Pathfinder differential acceleration measurement and its application to LISA K. Danzmann The Status of LISA Chair: O. Jennrich J. Martino On-flight characterization of Coldgas micro-Newton thrusters for Lisa Pathfinder M. Nofrarias Magnetic force noise in LISA Pathfinder L. Ferraioli The LISA Pathfinder GRS Front-End Electronics D. Vetrugno The Δ g workflow: from measured displacements to the differential external acceleration. A. Wittchen Coupling of relative intensity noise and pathlength noise to the length measurement in the optical metrology system of LISA Pathfinder S. Paczkowski Laser frequency stabilisation and interferometer path length differences on LISA Pathfinder R. Giusteri The free-fall mode experiment on LISA Pathfinder: first results P. Wass Electrostatic test-mass force-noise disturbances as measured by LISA Pathfinder R. Dolesi The contribution of Brownian noise from viscous gas damping to the differential acceleration noise measured in LISA Pathfinder between two nominally free falling test masses C. Trenkel The engineering of LISA Pathfinder – the quietest laboratory ever flown in space W. Klipstein LISA-derived Flight Phasemeter on the GRACE Follow-On Mission P. Laufer MEMS Ion Thruster Chips to Significantly Enhance Cold Gas Thruster Lifetime for LISA M. Tinto Enhanced Gravitational Wave Science with LISA and gLISA Tuesday, 6th of September 2016 Chair: P. McNamara F. Ricci Advanced VIRGO: State of the Art C. Belczynski Evolutionary predictions in the advanced LIGO/Virgo era A. Sesana The promise of multi

  4. Description of charging/discharging processes of the LISA sensors

    International Nuclear Information System (INIS)

    Sumner, Tim; Araujo, Henrique; Davidge, David; Howard, Alex; Lee, Chris; Rochester, Geoff; Shaul, Diana; Wass, Peter

    2004-01-01

    The next generation of gravitational experiments in space is likely to use completely isolated proof-masses. For example, LISA uses proof-masses as mirrors in interferometers for gravitational wave astronomy (Bender et al 1998 Pre-phase A report MPG-233 pp 1-191) and STEP uses proof-masses in Earth orbit for an equivalence principle test (Sumner et al 2003 at press). Nongravitational forces will act on these proof-masses if they become charged, through the action of cosmic rays and solar flare particles for example. This paper examines the consequences of proof-mass charging for LISA, and presents results from using GEANT4 to assess the charging processes. Finally, there is a brief discussion of a means of controlling the charge down to an acceptable level

  5. LISA Sources in Milky Way Globular Clusters.

    Science.gov (United States)

    Kremer, Kyle; Chatterjee, Sourav; Breivik, Katelyn; Rodriguez, Carl L; Larson, Shane L; Rasio, Frederic A

    2018-05-11

    We explore the formation of double-compact-object binaries in Milky Way (MW) globular clusters (GCs) that may be detectable by the Laser Interferometer Space Antenna (LISA). We use a set of 137 fully evolved GC models that, overall, effectively match the properties of the observed GCs in the MW. We estimate that, in total, the MW GCs contain ∼21 sources that will be detectable by LISA. These detectable sources contain all combinations of black hole (BH), neutron star, and white dwarf components. We predict ∼7 of these sources will be BH-BH binaries. Furthermore, we show that some of these BH-BH binaries can have signal-to-noise ratios large enough to be detectable at the distance of the Andromeda galaxy or even the Virgo cluster.

  6. The first mock data challenge for LISA Pathfinder

    Energy Technology Data Exchange (ETDEWEB)

    Monsky, A; Hewitson, M; Wanner, G; Nofrarias, M; Diepholz, I; Danzmann, K [Albert-Einstein-Institut, Max-Planck-Institut fuer Gravitationsphysik und Universitaet Hannover, 30167 Hannover (Germany); Ferraioli, L; Hueller, M; Cavalleri, A; Ciani, G; Dolesi, R [Dipartimento di Fisica, Universita di Trento and INFN, Gruppo Collegato di Trento, 38050 Povo, Trento (Italy); Grynagier, A [Institut fuer Flugmechanik und Flugregelung, 70569 Stuttgart (Germany); Armano, M [European Space Agency, ESAC, Villanueva de la Canada, 28692 Madrid (Spain); Benedetti, M [Dipartimento di Ingegneria dei Materiali e Tecnologie Industriali, Universita di Trento and INFN, Gruppo Collegato di Trento, Mesiano, Trento (Italy); Bogenstahl, J [Department of Physics and Astronomy, University of Glasgow, Glasgow (United Kingdom); Bortoluzzi, D; Bosetti, P; Cristofolini, I [Dipartimento di Ingegneria Meccanica e Strutturale, Universita di Trento and INFN, Gruppo Collegato di Trento, Mesiano, Trento (Italy); Brandt, N [Astrium GmbH, 88039 Friedrichshafen (Germany); Cruise, M, E-mail: anneke.monsky@aei.mpg.d [Department of Physics and Astronomy, University of Birmingham, Birmingham (United Kingdom)

    2009-05-07

    The data analysis of the LISA Technology Package (LTP) will comprise a series of discrete experiments, each focusing on a particular noise measurement or characterization of the instrument in various operating modes. Each of these experiments must be analysed and planned in advance of the mission because the results of a given experiment will have an impact on those that follow. As such, a series of mock data challenges (MDCs) will be developed and carried out with the aim of preparing the analysis tools and optimizing the various planned analyses. The first of these MDCs (MDC1) is a simplified treatment of the dynamics along the axis joining the two test masses onboard LISA Pathfinder. The validation of the dynamical model by predicting the spectra of the interferometer output data is shown, a prediction for the data analysis is calculated and, finally, several simulated interferometer data sets are analysed and calibrated to equivalent out-of-loop test mass acceleration.

  7. Alternative opto-mechanical architectures for the LISA instrument

    Energy Technology Data Exchange (ETDEWEB)

    Weise, Dennis R; Marenaci, Pierangelo; Weimer, Peter; Schulte, Hans Reiner; Gath, Peter; Johann, Ulrich, E-mail: dennis.weise@astrium.eads.ne [EADS Astrium GmbH, Claude-Dornier-Str., 88039 Friedrichshafen (Germany)

    2009-03-01

    As part of the on-going LISA Mission Formulation study under ESA contract, EADS Astrium has recently suggested and investigated a variety of novel LISA payload architectures utilizing so-called 'In-Field Pointing' for accommodation of seasonal constellation dynamics. Here, the annual variation in the angle between the interferometer arms of roughly +-1 deg. is compensated by steering the lines of sight of the individual telescopes with a small actuated mirror located in an intermediate pupil plane inside the telescopes. This introduces a certain flexibility for the overall payload configuration and allows for very compact designs. In particular, it enables a 'single active proof mass' mode with a true cold redundancy between a nominal and a backup GRS system on board each spacecraft, and thus enhances mission robustness.

  8. Recent progress at NASA in LISA formulation and technology development

    International Nuclear Information System (INIS)

    Stebbins, R T

    2008-01-01

    Over the last year, the NASA half of the joint LISA project has focused its efforts on responding to a major review, and advancing the formulation and technology development of the mission. The NAS/NRC Beyond Einstein program assessment review will be described, including the outcome. The basis of the LISA science requirements has changed from detection determined by integrated signal-to-noise ratio to observation determined by uncertainty in the estimation of astrophysical source parameters. The NASA team has further defined the spacecraft bus design, participated in many design trade studies and advanced the requirements flow down and the associated current best estimates of performance. Recent progress in technology development is also summarized

  9. Report on the second Mock LISA data challenge

    International Nuclear Information System (INIS)

    Babak, Stanislav; Porter, Edward K; Baker, John G; Benacquista, Matthew J; Cornish, Neil J; Littenberg, Tyson B; Crowder, Jeff; Cutler, Curt; Vallisneri, Michele; Larson, Shane L; Vecchio, Alberto; Auger, Gerard; Barack, Leor; Blaut, Arkadiusz; Bloomer, Ed; Clark, James; Brown, Duncan A; Fairhurst, Stephen; Christensen, Nelson; Gair, Jonathan R

    2008-01-01

    The Mock LISA data challenges are a program to demonstrate LISA data-analysis capabilities and to encourage their development. Each round of challenges consists of several data sets containing simulated instrument noise and gravitational waves from sources of undisclosed parameters. Participants are asked to analyze the data sets and report the maximum information about the source parameters. The challenges are being released in rounds of increasing complexity and realism: here we present the results of Challenge 2, issued in Jan 2007, which successfully demonstrated the recovery of signals from nonspinning supermassive-black-hole binaries with optimal SNRs between ∼10 and 2000, from ∼20 000 overlapping galactic white-dwarf binaries (among a realistically distributed population of 26 million), and from the extreme-mass-ratio inspirals of compact objects into central galactic black holes with optimal SNRs ∼100

  10. Possible LISA follow-on mission scientific objectives

    International Nuclear Information System (INIS)

    Bender, Peter L; Begelman, Mitchell C; Gair, Jonathan R

    2013-01-01

    A major objective that has been suggested for a follow-on mission to a Laser Interferometer Space Antenna (LISA)-type mission is to investigate more completely how intermediate mass black holes were formed and grew in the early universe, before they evolved into the much more massive black holes at the centers of many galaxies today. The actual design of such a follow-on mission will of course depend on what is observed by a LISA-type mission, such as the recently modified proposal for an evolved LISA mission, with the interferometer arm lengths between spacecraft reduced from 5 million to 1 million km. However, the sensitivity goals of a follow-on mission are likely to be influenced strongly by the desire to be able to see mergers of 10 M ⊙ black holes with roughly 3000 M ⊙ or larger intermediate mass black holes out to as large redshifts as possible. Approximate calculations of the expected signal-to-noise have been made for a possible LISA follow-on mission that was suggested about eight years ago (Bender and Begelman 2005 Trends in Space Science and Cosmic Vision 2020 (Noordwijk: ESA Publications Division) pp 33–38), and was called the Advanced Laser Interferometer Antenna. Based on the calculations, it appears that detections out to a redshift of 10 would be possible for 10 M ⊙ black holes spiraling into perhaps 5000 M ⊙ or larger intermediate mass black holes if the extragalactic gravitational wave background due to close white dwarf binaries is in the currently estimated range. (paper)

  11. Cosmological Backgrounds of Gravitational Waves and eLISA

    OpenAIRE

    Dufaux, Jean-Francois

    2012-01-01

    We review cosmological backgrounds of gravitational waves with a particular attention to the scientific potential of the eLISA/NGO mission. After an overview of cosmological backgrounds and detectors, we consider different cosmological sources that could lead to an observable signal. We then study the backgrounds produced by first-order phase transitions and networks of cosmic strings, assessing the prospects for their detection.

  12. Implementation of time-delay interferometry for LISA

    International Nuclear Information System (INIS)

    Tinto, Massimo; Shaddock, Daniel A.; Sylvestre, Julien; Armstrong, J.W.

    2003-01-01

    We discuss the baseline optical configuration for the Laser Interferometer Space Antenna (LISA) mission, in which the lasers are not free-running, but rather one of them is used as the main frequency reference generator (the master) and the remaining five as slaves, these being phase-locked to the master (the master-slave configuration). Under the condition that the frequency fluctuations due to the optical transponders can be made negligible with respect to the secondary LISA noise sources (mainly proof-mass and shot noises), we show that the entire space of interferometric combinations LISA can generate when operated with six independent lasers (the one-way method) can also be constructed with the master-slave system design. The corresponding hardware trade-off analysis for these two optical designs is presented, which indicates that the two sets of systems needed for implementing the one-way method, and the master-slave configuration, are essentially identical. Either operational mode could therefore be implemented without major implications on the hardware configuration. We then derive the required accuracies of armlength knowledge, time synchronization of the onboard clocks, sampling times and time-shifts needed for effectively implementing time-delay interferometry for LISA. We find that an armlength accuracy of about 16 meters, a synchronization accuracy of about 50 ns, and the time jitter due to a presently existing space qualified clock will allow the suppression of the frequency fluctuations of the lasers below to the level identified by the secondary noise sources. A new procedure for sampling the data in such a way to avoid the problem of having time shifts that are not integer multiples of the sampling time is also introduced, addressing one of the concerns about the implementation of time-delay interferometry

  13. UV-LED-based charge control for LISA

    Science.gov (United States)

    Olatunde, Taiwo; Shelley, Ryan; Chilton, Andrew; Ciani, Giacomo; Mueller, Guido; Conklin, John

    2014-03-01

    The test masses inside the LISA gravitational reference sensors (GRS) must maintain almost pure geodesic motion for gravitational waves to be successfully detected. The residual accelerations have to stay below 3fm/s2/rtHz at all frequencies between 0.1 and 3 mHz. One of the well known noise sources is associated with the charges on the test masses which couple to stray electrical potentials and external electro-magnetic fields. The LISA pathfinder (LPF) will use Hg-discharge lamps emitting mostly around 253 nm to discharge the test masses via photoemission in its 2015/16 flight. A future LISA mission launched around 2030 will likely replace the lamps with newer UV-LEDs. UV-LEDs have a lower mass, a better power efficiency, and are smaller than their Hg counterparts. Furthermore, the latest generation produces light at 240 nm, with energy well above the work function of pure gold. I will describe a preliminary design for effective charge control through photoelectric effect by using these LEDs. The effectiveness of this method is verified by taking Quantum Efficiency (QE) measurements which relate the number of electrons emitted to the number of photons incident on the Au test mass surface. This presentation addresses our initial results and future plans which includes implementation and testing in the UF torsion pendulum and space-qualification in a small satellite mission which will launch in the summer of 2014, through a collaboration with Stanford, KACST, and NASA Ames Research Center.

  14. Nested sampling as a tool for LISA data analysis

    International Nuclear Information System (INIS)

    Gair, Jonathan R; Feroz, Farhan; Graff, Philip; Hobson, Michael P; Babak, Stanislav; Petiteau, Antoine; Porter, Edward K

    2010-01-01

    Nested sampling is a technique for efficiently computing the probability of a data set under a particular hypothesis, also called the Bayesian Evidence or Marginal Likelihood, and for evaluating the posterior. MULTINEST is a multi-modal nested sampling algorithm which has been designed to efficiently explore and characterize posterior probability surfaces containing multiple secondary solutions. We have applied the MULTINEST algorithm to a number of problems in gravitational wave data analysis. In this article, we describe the algorithm and present results for several applications of the algorithm to analysis of mock LISA data. We summarise recently published results for a test case in which we searched for two non-spinning black hole binary merger signals in simulated LISA data. We also describe results obtained with MULTINEST in the most recent round of the Mock LISA Data Challenge (MLDC), in which the algorithm was used to search for and characterise both spinning supermassive black hole binary inspirals and bursts from cosmic string cusps. In all these applications, the algorithm found the correct number of signals and efficiently recovered the posterior probability distribution. Moreover, in most cases the waveform corresponding to the best a-posteriori parameters had an overlap in excess of 99% with the true signal.

  15. Nested sampling as a tool for LISA data analysis

    Energy Technology Data Exchange (ETDEWEB)

    Gair, Jonathan R [Institute of Astronomy, Madingley Road, CB3 0HA, Cambridge (United Kingdom); Feroz, Farhan; Graff, Philip; Hobson, Michael P [Astrophysics Group, Cavendish Laboratory, JJ Thomson Avenue, Cambridge CB3 0HE (United Kingdom); Babak, Stanislav; Petiteau, Antoine [Max-Planck-Institut fuer Gravitationsphysik, Am Muehlenberg 1, 14476, Potsdam (Germany); Porter, Edward K, E-mail: jgair@ast.cam.ac.u [APC, UMR 7164, Universite Paris 7 Denis Diderot, 10, rue Alice Domon et Leonie Duquet, 75205 Paris Cedex 13 (France)

    2010-05-01

    Nested sampling is a technique for efficiently computing the probability of a data set under a particular hypothesis, also called the Bayesian Evidence or Marginal Likelihood, and for evaluating the posterior. MULTINEST is a multi-modal nested sampling algorithm which has been designed to efficiently explore and characterize posterior probability surfaces containing multiple secondary solutions. We have applied the MULTINEST algorithm to a number of problems in gravitational wave data analysis. In this article, we describe the algorithm and present results for several applications of the algorithm to analysis of mock LISA data. We summarise recently published results for a test case in which we searched for two non-spinning black hole binary merger signals in simulated LISA data. We also describe results obtained with MULTINEST in the most recent round of the Mock LISA Data Challenge (MLDC), in which the algorithm was used to search for and characterise both spinning supermassive black hole binary inspirals and bursts from cosmic string cusps. In all these applications, the algorithm found the correct number of signals and efficiently recovered the posterior probability distribution. Moreover, in most cases the waveform corresponding to the best a-posteriori parameters had an overlap in excess of 99% with the true signal.

  16. Algebraic approach to time-delay data analysis for LISA

    International Nuclear Information System (INIS)

    Dhurandhar, S.V.; Nayak, K. Rajesh; Vinet, J.-Y.

    2002-01-01

    Cancellation of laser frequency noise in interferometers is crucial for attaining the requisite sensitivity of the triangular three-spacecraft LISA configuration. Raw laser noise is several orders of magnitude above the other noises and thus it is essential to bring it down to the level of other noises such as shot, acceleration, etc. Since it is impossible to maintain equal distances between spacecrafts, laser noise cancellation must be achieved by appropriately combining the six beams with appropriate time delays. It has been shown in several recent papers that such combinations are possible. In this paper, we present a rigorous and systematic formalism based on algebraic geometrical methods involving computational commutative algebra, which generates in principle all the data combinations canceling the laser frequency noise. The relevant data combinations form the first module of syzygies, as it is called in the literature of algebraic geometry. The module is over a polynomial ring in three variables, the three variables corresponding to the three time delays around the LISA triangle. Specifically, we list several sets of generators for the module whose linear combinations with polynomial coefficients generate the entire module. We find that this formalism can also be extended in a straightforward way to cancel Doppler shifts due to optical bench motions. The two modules are in fact isomorphic. We use our formalism to obtain the transfer functions for the six beams and for the generators. We specifically investigate monochromatic gravitational wave sources in the LISA band and carry out the maximization over linear combinations of the generators of the signal-to-noise ratios with the frequency and source direction angles as parameters

  17. GCR flux 9-day variations with LISA Pathfinder

    International Nuclear Information System (INIS)

    Grimani, C; Benella, S; Fabi, M; Finetti, N; Telloni, D

    2017-01-01

    Galactic cosmic-ray (GCR) energy spectra in the heliosphere vary on the basis of the level of solar activity, the status of solar polarity and interplanetary transient magnetic structures of solar origin. A high counting rate particle detector (PD) aboard LISA Pathfinder (LPF) allows for the measurement of galactic cosmic-ray and solar energetic particle (SEP) integral fluxes at energies > 70 MeV n −1 up to 6500 counts s −1 . Data are gathered with a sampling time of 15 s. A study of GCR flux depressions associated with the third harmonic of the Sun rotation period (∼ 9 days) is presented here. (paper)

  18. Energy transport in mirror machine LISA at electron cyclotron resonance

    International Nuclear Information System (INIS)

    Cunha Rapozo, C. da; Serbeto, A.; Torres-Silva, H.

    1993-01-01

    It is shown that a classical transport calculation is adequate to predict the steady state temperature of the RF produced plasma in LISA machine for both large and small resonant volumes. Temperature anisotropy ranging from 55 to 305 was found which was larger for small resonant volume, and the temperature relaxation was larger at large resonant one. This agrees with the fact that there is a Coulomb relaxation ν c which is proportional to T e -3/2 . It is also shown that the fitting parameter alpha is larger for large resonant volume than for small resonant one. (L.C.J.A.)

  19. A study on the radionuclide migration by means of the code LISA

    International Nuclear Information System (INIS)

    Frenquellucci, F.; Deserti, M.

    1989-01-01

    LISA code (Long Term Isolation Safety Assessment) has been developed by J.R.C. EUROATOM Ispra (Radiochemistry Division) and it's utilized in order to study migration of radionuclides through porous media. Aim of the present work is to analyze LISA's input and output files. A brief description of the code is also performed. As LISA is a research and in development code, its structure is rather complex and an exhaustive description of input/output files is helpful for the user. Version 3 of LISA code, loaded on ENEA's IBM 3090, is avaylable by ENEA-VEL Bologna

  20. Prospects of eLISA for Detecting Galactic Binary Black Holes Similar to GW150914

    OpenAIRE

    Seto, Naoki

    2016-01-01

    We discuss the prospects of eLISA for detecting gravitational waves (GWs) from Galactic binary black holes (BBHs) similar to GW150914. For a comoving merger rate that is consistent with current observation, eLISA is likely to identify at least one BBH with a sufficient signal-to-noise ratio. In addition, eLISA has a potential to measure the eccentricity of the BBH as small as $e\\sim 0.02$, corresponding to the residual value $e\\sim 10^{-6}$ at 10Hz. Therefore, eLISA could provide us with a cr...

  1. The magnetic diagnostics subsystem of the LISA Technology Package

    Energy Technology Data Exchange (ETDEWEB)

    Diaz-Aguilo, M; Garcia-Berro, E [Departament de Fisica Aplicada, Universitat Politecnica de Catalunya, c/Esteve Terrades, 5, 08860 Castelldefels (Spain); Lobo, A; Mateos, N; Sanjuan, J, E-mail: marc.diaz.aguilo@fa.upc.ed [Institut d' Estudis Espacials de Catalunya, c/Gran Capita 2-4, Edif. Nexus 104, 08034 Barcelona (Spain)

    2010-05-01

    The Magnetic Diagnostics Subsystem of the LISA Technology Package (LTP) on board the LISA Pathfinder (LPF) spacecraft includes a set of four tri-axial fluxgate magnetometers, intended to measure with high precision the magnetic field at the positions they occupy. However, their readouts do not provide a direct measurement of the magnetic field at the positions of the test masses. Therefore, an interpolation method must be implemented to obtain this information. However, such interpolation process faces serious difficulties. Indeed, the size of the interpolation region is excessive for a linear interpolation to be reliable, and the number of magnetometer channels does not provide sufficient data to go beyond that poor approximation. Recent research points to a possible alternative to address the magnetic interpolation problem by means of neural network algorithms. The key point of this approach is the ability neural networks have to learn from suitable training data representing the magnetic field behaviour. Despite the large distance to the test masses and the insufficient magnetic readings, artificial neural networks are able to significantly reduce the estimation error to acceptable levels. The learning efficiency can be best improved by making use of data obtained from on-ground measurements prior to mission launch in all relevant satellite locations and under real operation conditions. Reliable information on that appears to be essential for a meaningful assessment of magnetic noise in the LTP.

  2. Towards an improved magnetic diagnostic system for LISA

    International Nuclear Information System (INIS)

    Mateos, I; Lobo, A; Sanjuan, J; Ramos-Castro, J; Nofrarias, M

    2009-01-01

    The current design, and material implementation of the magnetic field sensing in the LISA Technology Package (LTP) on board LISA Pathfinder (LPF), is based on a set of 4 high-precision 3-axis fluxgate magnetometers. In order to avoid magnetic disturbances on the LTP proof masses (TM 's), originated by the sensors themselves, these are placed somewhat far from the TM's, which results in partial field information losses. We are currently investigating alternative magnetic sensing techniques, based on AMR (Anisotropic Magnetoresistive) devices. These are much smaller in size than fluxgates, therefore a more numerous array can be thought of for flight. In addition, there is a chance that they may be attached closer to the TM's, thereby enhancing magnetic field sensing spacial resolution. Several issues need to be addressed, such as real sensitivity (including electronics noise) and set/reset trigger procedures. A brief overview about the stability of the magnetic fields and gradients generated in the LTP by means of the coil will also be given. This paper show the latest results of our research.

  3. The magnetic diagnostics subsystem of the LISA Technology Package

    International Nuclear Information System (INIS)

    Diaz-Aguilo, M; Garcia-Berro, E; Lobo, A; Mateos, N; Sanjuan, J

    2010-01-01

    The Magnetic Diagnostics Subsystem of the LISA Technology Package (LTP) on board the LISA Pathfinder (LPF) spacecraft includes a set of four tri-axial fluxgate magnetometers, intended to measure with high precision the magnetic field at the positions they occupy. However, their readouts do not provide a direct measurement of the magnetic field at the positions of the test masses. Therefore, an interpolation method must be implemented to obtain this information. However, such interpolation process faces serious difficulties. Indeed, the size of the interpolation region is excessive for a linear interpolation to be reliable, and the number of magnetometer channels does not provide sufficient data to go beyond that poor approximation. Recent research points to a possible alternative to address the magnetic interpolation problem by means of neural network algorithms. The key point of this approach is the ability neural networks have to learn from suitable training data representing the magnetic field behaviour. Despite the large distance to the test masses and the insufficient magnetic readings, artificial neural networks are able to significantly reduce the estimation error to acceptable levels. The learning efficiency can be best improved by making use of data obtained from on-ground measurements prior to mission launch in all relevant satellite locations and under real operation conditions. Reliable information on that appears to be essential for a meaningful assessment of magnetic noise in the LTP.

  4. Classifying LISA gravitational wave burst signals using Bayesian evidence

    International Nuclear Information System (INIS)

    Feroz, Farhan; Graff, Philip; Hobson, Michael P; Lasenby, Anthony; Gair, Jonathan R

    2010-01-01

    We consider the problem of characterization of burst sources detected by the Laser Interferometer Space Antenna (LISA) using the multi-modal nested sampling algorithm, MultiNest. We use MultiNest as a tool to search for modelled bursts from cosmic string cusps, and compute the Bayesian evidence associated with the cosmic string model. As an alternative burst model, we consider sine-Gaussian burst signals, and show how the evidence ratio can be used to choose between these two alternatives. We present results from an application of MultiNest to the last round of the Mock LISA Data Challenge, in which we were able to successfully detect and characterize all three of the cosmic string burst sources present in the release data set. We also present results of independent trials and show that MultiNest can detect cosmic string signals with signal-to-noise ratio (SNR) as low as ∼7 and sine-Gaussian signals with SNR as low as ∼8. In both cases, we show that the threshold at which the sources become detectable coincides with the SNR at which the evidence ratio begins to favour the correct model over the alternative.

  5. Disentangling the magnetic force noise contribution in LISA Pathfinder

    International Nuclear Information System (INIS)

    Armano, M; Audley, H; Born, M; Danzmann, K; Diepholz, I; Auger, G; Binetruy, P; Baird, J; Bortoluzzi, D; Brandt, N; Fitzsimons, E; Bursi, A; Caleno, M; Cavalleri, A; Cesarini, A; Dolesi, R; Ferroni, V; Cruise, M; Dunbar, N; Ferraioli, L

    2015-01-01

    Magnetically-induced forces on the inertial masses on-board LISA Pathfinder are expected to be one of the dominant contributions to the mission noise budget, accounting for up to 40%. The origin of this disturbance is the coupling of the residual magnetization and susceptibility of the test masses with the environmental magnetic field. In order to fully understand this important part of the noise model, a set of coils and magnetometers are integrated as a part of the diagnostics subsystem. During operations a sequence of magnetic excitations will be applied to precisely determine the coupling of the magnetic environment to the test mass displacement using the on-board magnetometers. Since no direct measurement of the magnetic field in the test mass position will be available, an extrapolation of the magnetic measurements to the test mass position will be carried out as a part of the data analysis activities. In this paper we show the first results on the magnetic experiments during an end- to-end LISA Pathfinder simulation, and we describe the methods under development to map the magnetic field on-board. (paper)

  6. Revised electrostatic model of the LISA Pathfinder inertial sensor

    Energy Technology Data Exchange (ETDEWEB)

    Brandt, Nico [Astrium GmbH, 88039 Friedrichshafen (Germany); Fichter, Walter, E-mail: nico.brandt@astrium.eads.ne [iFR, Universitaet Stuttgart, Pfaffenwaldring 7a, 70569 Stuttgart (Germany)

    2009-03-01

    A comprehensive electrostatic finite-element (FE) analysis of the LISA Pathfinder Inertial Sensor (IS) has been carried out at Astrium GmbH. Starting with a detailed geometrical model of the IS housing and test mass (TM) flight units, FE results were derived from multiple analyses runs applying the Maxwell 3D field simulation software. The electrostatic forces and torques on the TM in 6DoF, as well as all non-negligible capacitances between the TM, the 18 electrodes, and the housing, have been extracted for different TM translations and rotations. The results of the FE analyses were expected to confirm the existing IS electrostatic model predictions used for performance analysis, simulations, and on-board algorithms. Major discrepancies were found, however, between the results and the model used so far. In general, FE results give considerably larger capacitance values than the equivalent infinite non-parallel plate estimates. In contrast, the FE derived forces and torques are in general significantly lower compared to the analytic IS electrostatic model predictions. In this paper, these results are discussed in detail and the reasons for the deviations are elaborated. Based on these results, an adapted analytic IS electrostatic model is proposed that reflects the electrostatic forces, torques, and stiffness values in the LISA Pathfinder IS significantly more accurate.

  7. Revised electrostatic model of the LISA Pathfinder inertial sensor

    International Nuclear Information System (INIS)

    Brandt, Nico; Fichter, Walter

    2009-01-01

    A comprehensive electrostatic finite-element (FE) analysis of the LISA Pathfinder Inertial Sensor (IS) has been carried out at Astrium GmbH. Starting with a detailed geometrical model of the IS housing and test mass (TM) flight units, FE results were derived from multiple analyses runs applying the Maxwell 3D field simulation software. The electrostatic forces and torques on the TM in 6DoF, as well as all non-negligible capacitances between the TM, the 18 electrodes, and the housing, have been extracted for different TM translations and rotations. The results of the FE analyses were expected to confirm the existing IS electrostatic model predictions used for performance analysis, simulations, and on-board algorithms. Major discrepancies were found, however, between the results and the model used so far. In general, FE results give considerably larger capacitance values than the equivalent infinite non-parallel plate estimates. In contrast, the FE derived forces and torques are in general significantly lower compared to the analytic IS electrostatic model predictions. In this paper, these results are discussed in detail and the reasons for the deviations are elaborated. Based on these results, an adapted analytic IS electrostatic model is proposed that reflects the electrostatic forces, torques, and stiffness values in the LISA Pathfinder IS significantly more accurate.

  8. T.D Lee and Lisa Randall visit ATLAS

    CERN Multimedia

    Pauline Gagnon

    Professor Tsung-Dao Lee, who received the Nobel Prize for Physics in 1957 for postulating that parity is not conserved in weak interactions, visited the ATLAS detector this month. He is seen here in the company of Peter Jenni, spokesperson for ATLAS. T.D. Lee is still very active at over 80, pursuing his theory work to this day. Professor Lisa Randall from Harvard University, the well-known theorist behind the Randall-Sundrum theory for extra dimensions, was also part of the group visiting the ATLAS detector. She is seen here with Fabiola Gianotti, deputy spokesperson for ATLAS. Lisa Randall's two initial papers have been quoted both more than 2500 times, making her the most cited theoretical physicist in the world in the last five years as of last autumn - a total of about 10,000 citations! One wonders here if Peter is pointing to a CP-violating graviton spotted in the ATLAS cavern... From left to right: Fabiola Gianotti, Gustaaf Brooijmans, convener of the ATLAS Exotics physics gro...

  9. White-dwarf-white-dwarf galactic background in the LISA data

    International Nuclear Information System (INIS)

    Edlund, Jeffrey A.; Tinto, Massimo; Krolak, Andrzej; Nelemans, Gijs

    2005-01-01

    LISA (Laser Interferometer Space Antenna) is a proposed space mission, which will use coherent laser beams exchanged between three remote spacecraft to detect and study low-frequency cosmic gravitational radiation. In the low part of its frequency band, the LISA strain sensitivity will be dominated by the incoherent superposition of hundreds of millions of gravitational wave signals radiated by inspiraling white-dwarf binaries present in our own Galaxy. In order to estimate the magnitude of the LISA response to this background, we have simulated a synthesized population that recently appeared in the literature. Our approach relies on entirely analytic expressions of the LISA time-delay interferometric responses to the gravitational radiation emitted by such systems, which allows us to implement a computationally efficient and accurate simulation of the background in the LISA data. We find the amplitude of the galactic white-dwarf binary background in the LISA data to be modulated in time, reaching a minimum equal to about twice that of the LISA noise for a period of about two months around the time when the Sun-LISA direction is roughly oriented towards the Autumn equinox. This suggests that, during this time period, LISA could search for other gravitational wave signals incoming from directions that are away from the galactic plane. Since the galactic white-dwarf background will be observed by LISA not as a stationary but rather as a cyclostationary random process with a period of 1 yr, we summarize the theory of cyclostationary random processes, present the corresponding generalized spectral method needed to characterize such process, and make a comparison between our analytic results and those obtained by applying our method to the simulated data. We find that, by measuring the generalized spectral components of the white-dwarf background, LISA will be able to infer properties of the distribution of the white-dwarf binary systems present in our Galaxy

  10. Beyond the Required LISA Free-Fall Performance: New LISA Pathfinder Results down to 20 μ Hz

    Science.gov (United States)

    Armano, M.; Audley, H.; Baird, J.; Binetruy, P.; Born, M.; Bortoluzzi, D.; Castelli, E.; Cavalleri, A.; Cesarini, A.; Cruise, A. M.; Danzmann, K.; de Deus Silva, M.; Diepholz, I.; Dixon, G.; Dolesi, R.; Ferraioli, L.; Ferroni, V.; Fitzsimons, E. D.; Freschi, M.; Gesa, L.; Gibert, F.; Giardini, D.; Giusteri, R.; Grimani, C.; Grzymisch, J.; Harrison, I.; Heinzel, G.; Hewitson, M.; Hollington, D.; Hoyland, D.; Hueller, M.; Inchauspé, H.; Jennrich, O.; Jetzer, P.; Karnesis, N.; Kaune, B.; Korsakova, N.; Killow, C. J.; Lobo, J. A.; Lloro, I.; Liu, L.; López-Zaragoza, J. P.; Maarschalkerweerd, R.; Mance, D.; Meshksar, N.; Martín, V.; Martin-Polo, L.; Martino, J.; Martin-Porqueras, F.; Mateos, I.; McNamara, P. W.; Mendes, J.; Mendes, L.; Nofrarias, M.; Paczkowski, S.; Perreur-Lloyd, M.; Petiteau, A.; Pivato, P.; Plagnol, E.; Ramos-Castro, J.; Reiche, J.; Robertson, D. I.; Rivas, F.; Russano, G.; Slutsky, J.; Sopuerta, C. F.; Sumner, T.; Texier, D.; Thorpe, J. I.; Vetrugno, D.; Vitale, S.; Wanner, G.; Ward, H.; Wass, P. J.; Weber, W. J.; Wissel, L.; Wittchen, A.; Zweifel, P.

    2018-02-01

    In the months since the publication of the first results, the noise performance of LISA Pathfinder has improved because of reduced Brownian noise due to the continued decrease in pressure around the test masses, from a better correction of noninertial effects, and from a better calibration of the electrostatic force actuation. In addition, the availability of numerous long noise measurement runs, during which no perturbation is purposely applied to the test masses, has allowed the measurement of noise with good statistics down to 20 μ Hz . The Letter presents the measured differential acceleration noise figure, which is at (1.74 ±0.01 ) fm s-2/√{Hz } above 2 mHz and (6 ±1 ) ×10 fm s-2/√{Hz } at 20 μ Hz , and discusses the physical sources for the measured noise. This performance provides an experimental benchmark demonstrating the ability to realize the low-frequency science potential of the LISA mission, recently selected by the European Space Agency.

  11. Probing the Universe with Gravitational Waves: the Laser Interferometer Space Antenna (LISA)

    NARCIS (Netherlands)

    Prince, T.A.; Binetruy, P.; Centrella, J.; Finn, L.; Hogan, C.; Nelemans, G.A.; Phinney, S.

    2007-01-01

    - For the LISA International Science Team: LISA is a joint NASA/ESA space mission designed to measure gravitational waves in the band from 0.1 mHz to 0.1 Hz, a band that is richly populated by strong sources of gravitational waves. Signals will come from a wider range of sources: massive black holes

  12. Cavity Voltage Phase Modulation MD

    CERN Document Server

    Mastoridis, Themistoklis; Molendijk, John; Timko, Helga; CERN. Geneva. ATS Department

    2016-01-01

    The LHC RF/LLRF system is currently configured for extremely stable RF voltage to minimize transient beam loading effects. The present scheme cannot be extended beyond nominal beam current since the demanded power would exceed the peak klystron power and lead to saturation. A new scheme has therefore been proposed: for beam currents above nominal (and possibly earlier), the cavity phase modulation by the beam will not be corrected (transient beam loading), but the strong RF feedback and One-Turn Delay feedback will still be active for loop and beam stability in physics. To achieve this, the voltage set point will be adapted for each bunch. The goal of this MD was to test a new algorithm that would adjust the voltage set point to achieve the cavity phase modulation that would minimize klystron forward power.

  13. Control system design for the constellation acquisition phase of the LISA mission

    Energy Technology Data Exchange (ETDEWEB)

    Cirillo, Francesca; Gath, Peter F, E-mail: francesca.cirillo@astrium.eads.ne, E-mail: peter.gath@astrium.eads.ne [Astrium GmbH Satellites, 88039 Friedrichshafen (Germany)

    2009-03-01

    The objective of the constellation acquisition phase for the LISA mission is to establish the three laser links between the three spacecraft of the LISA constellation so that the interferometric measurements for the science experiment can commence. The laser beam acquisition for LISA is extremely challenging given the 5 million km distance between the spacecraft, the inherent limits of the attitude sensors accuracy, the orbit determination accuracy issues and the time required to phase-lock the incoming and outgoing laser signals. This paper presents the design of the control system for the acquisition phase of the LISA constellation: the acquisition operational procedure is outlined, guidance laws are defined together with the Gyro Mode attitude control principle, which implements a Kalman filter for disturbances rejection purposes. Constellation-wide non-linear simulations demonstrate that the LISA constellation acquisition phase is feasible by means of the proposed control strategy.

  14. Control system design for the constellation acquisition phase of the LISA mission

    International Nuclear Information System (INIS)

    Cirillo, Francesca; Gath, Peter F

    2009-01-01

    The objective of the constellation acquisition phase for the LISA mission is to establish the three laser links between the three spacecraft of the LISA constellation so that the interferometric measurements for the science experiment can commence. The laser beam acquisition for LISA is extremely challenging given the 5 million km distance between the spacecraft, the inherent limits of the attitude sensors accuracy, the orbit determination accuracy issues and the time required to phase-lock the incoming and outgoing laser signals. This paper presents the design of the control system for the acquisition phase of the LISA constellation: the acquisition operational procedure is outlined, guidance laws are defined together with the Gyro Mode attitude control principle, which implements a Kalman filter for disturbances rejection purposes. Constellation-wide non-linear simulations demonstrate that the LISA constellation acquisition phase is feasible by means of the proposed control strategy.

  15. Relativistic analysis of the LISA long range optical links

    International Nuclear Information System (INIS)

    Chauvineau, Bertrand; Regimbau, Tania; Vinet, Jean-Yves; Pireaux, Sophie

    2005-01-01

    The joint ESA/NASA LISA mission consists of three spacecraft on heliocentric orbits, flying in a triangular formation of 5 Mkm each side, linked by infrared optical beams. The aim of the mission is to detect gravitational waves in a low frequency band. For properly processing the scientific data, the propagation delays between spacecraft must be accurately known. We thus analyze the propagation of light between spacecraft in order to systematically derive the relativistic effects due to the static curvature of the Schwarzschild space-time in which the spacecraft are orbiting with time-varying light distances. In particular, our analysis allows us to evaluate rigorously the Sagnac effect, and the gravitational (Einstein) redshift

  16. LISA Pathfinder drag-free control and system implications

    International Nuclear Information System (INIS)

    Fichter, Walter; Gath, Peter; Vitale, Stefano; Bortoluzzi, Daniele

    2005-01-01

    The top-level requirement of the LISA Pathfinder mission is the verification of pure relative free fall between two test masses with an accuracy of about 3 x 10 -14 m s -2 Hz -1/2 in a measurement bandwidth between 1 mHz and 30 mHz. The drag-free control system is one of the key technology elements that shall be verified. Its design is strongly connected to the overall system and experimental design, in particular, via the following issues: the differential test mass motion and thus the science measurements depend on the control system; design constraints, such as negative stiffness of test masses and electrostatic actuation cross-talk, have an impact on science and control system performance; derived requirements for control system components, in particular, the micro-propulsion system, must be within reasonable and feasible limits. In this paper, the control design approach is outlined and the system-related issues are addressed

  17. The LISA Pathfinder interferometry-hardware and system testing

    Energy Technology Data Exchange (ETDEWEB)

    Audley, H; Danzmann, K; MarIn, A Garcia; Heinzel, G; Monsky, A; Nofrarias, M; Steier, F; Bogenstahl, J [Albert-Einstein-Institut, Max-Planck-Institut fuer Gravitationsphysik und Universitaet Hannover, 30167 Hannover (Germany); Gerardi, D; Gerndt, R; Hechenblaikner, G; Johann, U; Luetzow-Wentzky, P; Wand, V [EADS Astrium GmbH, Friedrichshafen (Germany); Antonucci, F [Dipartimento di Fisica, Universita di Trento and INFN, Gruppo Collegato di Trento, 38050 Povo, Trento (Italy); Armano, M [European Space Astronomy Centre, European Space Agency, Villanueva de la Canada, 28692 Madrid (Spain); Auger, G; Binetruy, P [APC UMR7164, Universite Paris Diderot, Paris (France); Benedetti, M [Dipartimento di Ingegneria dei Materiali e Tecnologie Industriali, Universita di Trento and INFN, Gruppo Collegato di Trento, Mesiano, Trento (Italy); Boatella, C, E-mail: antonio.garcia@aei.mpg.de [CNES, DCT/AQ/EC, 18 Avenue Edouard Belin, 31401 Toulouse, Cedex 9 (France)

    2011-05-07

    Preparations for the LISA Pathfinder mission have reached an exciting stage. Tests of the engineering model (EM) of the optical metrology system have recently been completed at the Albert Einstein Institute, Hannover, and flight model tests are now underway. Significantly, they represent the first complete integration and testing of the space-qualified hardware and are the first tests on an optical system level. The results and test procedures of these campaigns will be utilized directly in the ground-based flight hardware tests, and subsequently during in-flight operations. In addition, they allow valuable testing of the data analysis methods using the MATLAB-based LTP data analysis toolbox. This paper presents an overview of the results from the EM test campaign that was successfully completed in December 2009.

  18. Commissioning and operating experience with the LISA superconducting accelerator

    International Nuclear Information System (INIS)

    Castellano, M.; Ferrario, M.; Minestrini, M.; Patteri, P.; Tazzioli, F.; Kulinski, S.

    1996-06-01

    The commissioning of the LISA superconducting (SC) RF electron linac at INFN Frascati Laboratories has been concluded although, due to a change in program priorities, the full possibilities of the machine have not been exploited. In this report the authors illustrate the results achieved so far and the difficulties encountered in commissioning, with the hope that this material might be some of help to those who intend to start the enterprise of building a SC linac in a non specialized environment. The part concerning the SC system is particularly stressed, but a relevant attention is also devoted to the traditional room temperature injector, the proper setting of which is fundamental to achieving the high beam quality that such a machine allows

  19. Detecting white dwarf binaries in Mock LISA Data Challenge 3

    International Nuclear Information System (INIS)

    Blaut, A; Krolak, A; Babak, S

    2009-01-01

    We present a strategy for detecting gravitational wave signals from the Galactic white dwarf binaries in the Mock LISA Data Challenge 3 (MLDC3) and estimate their parameters. Our method is based on the matched filtering in the form of the F-statistic. We perform the search on three-dimensional space (sky coordinate and frequency of gravitational wave) below 3 mHz and include the fourth parameter (frequency derivative) at high frequencies. A template bank is used to search for the strongest signal in the data, then we remove it and repeat the search until we do not have signals in the data above a preselected threshold. For the template bank, we construct an optimal grid that realizes the best lattice covering with a constraint such that the nodes of the grid coincide with the Fourier frequencies. This enables the use of the fast Fourier transform algorithm to calculate the F-statistic.

  20. Strong lensing of gravitational waves as seen by LISA.

    Science.gov (United States)

    Sereno, M; Sesana, A; Bleuler, A; Jetzer, Ph; Volonteri, M; Begelman, M C

    2010-12-17

    We discuss strong gravitational lensing of gravitational waves from the merging of massive black hole binaries in the context of the LISA mission. Detection of multiple events would provide invaluable information on competing theories of gravity, evolution and formation of structures and, possibly, constraints on H0 and other cosmological parameters. Most of the optical depth for lensing is provided by intervening massive galactic halos, for which wave optics effects are negligible. Probabilities to observe multiple events are sizable for a broad range of formation histories. For the most optimistic models, up to ≲ 4 multiple events with a signal to noise ratio ≳ 8 are expected in a 5-year mission. Chances are significant even for conservative models with either light (≲ 60%) or heavy (≲ 40%) seeds. Because of lensing amplification, some intrinsically too faint signals are brought over threshold (≲ 2 per year).

  1. Interferometry for the LISA technology package (LTP) aboard SMART-2

    International Nuclear Information System (INIS)

    Heinzel, G; Braxmaier, C; Schilling, R; Ruediger, A; Robertson, D; Plate, M te; Wand, V; Arai, K; Johann, U; Danzmann, K

    2003-01-01

    The interferometer of the LISA technology package (LTP) on SMART-2 is needed to verify the performance of the gravitational sensors by monitoring the distance between two test masses with a noise level of 10 pm Hz -1/2 between 3 mHz and 30 mHz. It must continuously track the motion of the test mass distance while that distance changes by many μm with a speed of up to 20 μm s -1 , without losing track of the sign of the motion and without exerting any influence on the test masses that might lead to a motion above that level. As a result of a detailed comparison study, a heterodyne Mach-Zehnder interferometer was selected as the baseline for the SMART-2 mission. Its design and expected performance are described in this paper

  2. The effects of orbital motion on LISA time delay interferometry

    International Nuclear Information System (INIS)

    Cornish, Neil J; Hellings, Ronald W

    2003-01-01

    In an effort to eliminate laser phase noise in laser interferometer spaceborne gravitational wave detectors, several combinations of signals have been found that allow the laser noise to be cancelled out while gravitational wave signals remain. This process is called time delay interferometry (TDI). In the papers that defined the TDI variables, their performance was evaluated in the limit that the gravitational wave detector is fixed in space. However, the performance depends on certain symmetries in the armlengths that are available if the detector is fixed in space, but that will be broken in the actual rotating and flexing configuration produced by the LISA orbits. In this paper we investigate the performance of these TDI variables for the real LISA orbits. First, addressing the effects of rotation, we verify Daniel Shaddock's result that the Sagnac variables α (t), β (t) and γ (t) will not cancel out the laser phase noise, and we also find the same result for the symmetric Sagnac variable ζ (t). The loss of the latter variable would be particularly unfortunate since this variable also cancels out gravitational wave signal, allowing instrument noise in the detector to be isolated and measured. Fortunately, we have found a set of more complicated TDI variables, which we call Δ Sagnac variables, one of which accomplishes the same goal as ζ (t) to good accuracy. Finally, however, as we investigate the effects of the flexing of the detector arms due to non-circular orbital motion, we show that all variables, including the interferometer variables, X(t), Y(t) and Z(t), which survive the rotation-induced loss of direction symmetry, will not completely cancel laser phase noise when the armlengths are changing with time. This unavoidable problem will place a stringent requirement on laser stability of ∼5 Hz Hz -1/2

  3. The discovery of 260Md and the decay properties of 258Fm, 258m,gMd and 259Md

    International Nuclear Information System (INIS)

    Lougheed, R.W.; Hulet, E.K.; Dougan, R.J.; Wild, J.F.; Dupzyk, R.J.; Henderson, C.M.; Moody, K.J.; Hahn, R.L.; Suemmerer, K.; Bethune, G.

    1986-01-01

    We have discovered a new neutron-rich isotope, 260 Md, from 18 O and 22 Ne bombardments of 254 Es. We observed a spontaneous-fission (SF) activity with a half-life of 32 days in electromagnetically separated fractions with mass number 260 from these bombardments and we measured the mass and kinetic energy distributions of this SF activity. The mass distribution was symmetric with the principal energy peak at a total kinetic energy (TKE) of 234 MeV, similar to previous observations for heavy fermium isotopes. Surprisingly, we also observed a smaller symmetric component with a TKE of 195 MeV. We interpret these two peaks in the TKE distribution as arising from two types of fission in the same nucleus, or bimodal fission. The observed fission activity may be either from the SF decay of 260 Md or from 260 Fm which would arise from electron-capture (EC) decay of 260 Md. We have eliminated the possible β - decay of 260 Md by measuring β - -SF time correlations for the decay of 260 Md and we plan to determine whether 260 Md decays by EC by measuring time correlations between fermium X-rays and SF events. We also measured various properties of the heavy fermium and mendelevium isotopes and obtained 1. more accurate cross-sections for the neutron-rich mendelevium isotopes which we use to predict the production rates of yet undiscovered nuclides, 2. improved half-life measurements for 258m,g Md and 259 Md, 3. confirmation of the EC decay of 258m Md by measurement of the fermium X-rays preceding the SF decay of 258 Fm and 4. very substantially improved mass and TKE distributions for the SF decay of 258 Fm and 259 Md. (orig.)

  4. Harvesting graphics power for MD simulations

    NARCIS (Netherlands)

    van Meel, J.A.; Arnold, A.; Frenkel, D.; Portegies Zwart, S.F.; Belleman, R.G.

    2008-01-01

    We discuss an implementation of molecular dynamics (MD) simulations on a graphic processing unit (GPU) in the NVIDIA CUDA language. We tested our code on a modern GPU, the NVIDIA GeForce 8800 GTX. Results for two MD algorithms suitable for short-ranged and long-ranged interactions, and a

  5. Harvesting graphics power for MD simulations

    NARCIS (Netherlands)

    Meel, J.A. van; Arnold, A.; Frenkel, D.; Portegies Zwart, S.F.; Belleman, R.G.

    We discuss an implementation of molecular dynamics (MD) simulations on a graphic processing unit (GPU) in the NVIDIA CUDA language. We tested our code on a modern GPU, the NVIDIA GeForce 8800 GTX. Results for two MD algorithms suitable for short-ranged and long-ranged interactions, and a

  6. THE LISA GRAVITATIONAL WAVE FOREGROUND: A STUDY OF DOUBLE WHITE DWARFS

    International Nuclear Information System (INIS)

    Ruiter, Ashley J.; Belczynski, Krzysztof; Benacquista, Matthew; Williams, Gabriel; Larson, Shane L.

    2010-01-01

    Double white dwarfs (WDs) are expected to be a source of confusion-limited noise for the future gravitational wave observatory LISA. In a specific frequency range, this 'foreground noise' is predicted to rise above the instrumental noise and hinder the detection of other types of signals, e.g., gravitational waves arising from stellar-mass objects inspiraling into massive black holes. In many previous studies, only detached populations of compact object binaries have been considered in estimating the LISA gravitational wave foreground signal. Here, we investigate the influence of compact object detached and Roche-Lobe overflow (RLOF) Galactic binaries on the shape and strength of the LISA signal. Since >99% of remnant binaries that have orbital periods within the LISA sensitivity range are WD binaries, we consider only these binaries when calculating the LISA signal. We find that the contribution of RLOF binaries to the foreground noise is negligible at low frequencies, but becomes significant at higher frequencies, pushing the frequency at which the foreground noise drops below the instrumental noise to >6 mHz. We find that it is important to consider the population of mass-transferring binaries in order to obtain an accurate assessment of the foreground noise on the LISA data stream. However, we estimate that there still exists a sizeable number (∼11,300) of Galactic double WD binaries that will have a signal-to-noise ratio >5, and thus will be potentially resolvable with LISA. We present the LISA gravitational wave signal from the Galactic population of WD binaries, show the most important formation channels contributing to the LISA disk and bulge populations, and discuss the implications of these new findings.

  7. First thoughts on MD priorities for 2012

    CERN Document Server

    Zimmermann, F; Assmann, R

    2012-01-01

    In 2012, 22 days of beam time will be allocated for LHC MDs. In this paper, after recalling the 2011 LHC MD experience, the MD rrequests for 2012 are reviewed. Three primary MD themes for 2012 can be identified: 1)pushing performance in 2012, 2)preparing for 2014/15, and 3)towards maximum luminosity. Example topics include emittance growth in collision or enhanced satellites for theme 1), 25 ns operation for 2), and ATS optics for 3). Structures lists of MD requests and topics for each theme as well as some initial thoughts on the MD priorities are presented. For certain topics, "start-of-fill MDs" are proposed in order to most efficiently use of the available beam time.

  8. Annual modulation of the galactic binary confusion noise background and LISA data analysis

    International Nuclear Information System (INIS)

    Seto, Naoki

    2004-01-01

    We study the anisotropies of the galactic confusion noise background and its effects on LISA data analysis. LISA has two data streams of gravitational wave signals relevant for the low frequency regime. Because of the anisotropies of the background, the matrix for their confusion noises has off-diagonal components and depends strongly on the orientation of the detector plane. We find that the sky-averaged confusion noise level √(S(f)) could change by a factor of 2 in 3 months and would be minimum when the orbital position of LISA is around either the spring or autumn equinox

  9. Science with the space-based interferometer LISA. IV: probing inflation with gravitational waves

    International Nuclear Information System (INIS)

    Bartolo, Nicola; Guzzetti, Maria Chiara; Liguori, Michele; Matarrese, Sabino

    2016-01-01

    We investigate the potential for the LISA space-based interferometer to detect the stochastic gravitational wave background produced from different mechanisms during inflation. Focusing on well-motivated scenarios, we study the resulting contributions from particle production during inflation, inflationary spectator fields with varying speed of sound, effective field theories of inflation with specific patterns of symmetry breaking and models leading to the formation of primordial black holes. The projected sensitivities of LISA are used in a model-independent way for various detector designs and configurations. We demonstrate that LISA is able to probe these well-motivated inflationary scenarios beyond the irreducible vacuum tensor modes expected from any inflationary background.

  10. Science with the space-based interferometer LISA. IV: Probing inflation with gravitational waves

    CERN Document Server

    Bartolo, Nicola; Domcke, Valerie; Figueroa, Daniel G.; Garcia-Bellido, Juan; Guzzetti, Maria Chiara; Liguori, Michele; Matarrese, Sabino; Peloso, Marco; Petiteau, Antoine; Ricciardone, Angelo; Sakellariadou, Mairi; Sorbo, Lorenzo; Tasinato, Gianmassimo

    2016-01-01

    We investigate the potential for the LISA space-based interferometer to detect the stochastic gravitational wave background produced from different mechanisms during inflation. Focusing on well-motivated scenarios, we study the resulting contributions from particle production during inflation, inflationary spectator fields with varying speed of sound, effective field theories of inflation with specific patterns of symmetry breaking and models leading to the formation of primordial black holes. The projected sensitivities of LISA are used in a model-independent way for various detector designs and configurations. We demonstrate that LISA is able to probe these well-motivated inflationary scenarios beyond the irreducible vacuum tensor modes expected from any inflationary background.

  11. Radiation pressure calibration and test mass reflectivities for LISA Pathfinder

    International Nuclear Information System (INIS)

    Korsakova, Natalia; Kaune, Brigitte

    2017-01-01

    This paper describes a series of experiments which were carried out during the main operations of LISA Pathfinder. These experiments were performed by modulating the power of the measurement and reference beams. In one series of experiments the beams were sequentially switched on and off. In the other series of experiments the powers of the beams were modulated within 0.1% and 1% of the constant power. These experiments use recordings of the total power measured on the photodiodes to infer the properties of the Optical Metrology System (OMS), such as reflectivities of the test masses and change of the photodiode efficiencies with time. In the first case the powers are back propagated from the different photodiodes to the same place on the optical bench to express the unknown quantities in the measurement with the complimentary photodiode measurements. They are combined in the way that the only unknown left is the test mass reflectivities. The second experiment compared two estimates of the force applied to the test masses due to the radiation pressure that appears because of the beam modulations. One estimate of the force is inferred from the measurements of the powers on the photodiodes and propagation of this measurement to the test masses. The other estimation of the force is done by calculating it from the change in the main scientific output of the instrument – differential displacement of the two test masses. (paper)

  12. Analog phase lock between two lasers at LISA power levels

    International Nuclear Information System (INIS)

    Diekmann, Christian; Steier, Frank; Sheard, Benjamin; Heinzel, Gerhard; Danzmann, Karsten

    2009-01-01

    This paper presents the implementation of an analog optical phase-locked-loop with an offset frequency of about 20MHz between two lasers, where the detected light powers were of the order of 31 pW and 200 μW. The goal of this setup was the design and characterization of a photodiode transimpedance amplifier for application in LISA. By application of a transimpedance amplifier designed to have low noise and low power consumption, the phase noise between the two lasers was a factor of two above the shot noise limit down to 60mHz. The achievable phase sensitivity depends ultimately on the available power of the highly attenuated master laser and on the input current noise of the transimpedance amplifier of the photodetector. The limiting noise source below 60mHz was the analog phase measurement system that was used in this experiment. A digital phase measurement system that is currently under development at the AEI will be used in the near future. Its application should improve the sensitivity.

  13. Analog phase lock between two lasers at LISA power levels

    Energy Technology Data Exchange (ETDEWEB)

    Diekmann, Christian; Steier, Frank; Sheard, Benjamin; Heinzel, Gerhard; Danzmann, Karsten, E-mail: Christian.Diekmann@aei.mpg.d [Max-Planck-Institute for Gravitational Physics, Callinstr. 38, D-30167 Hannover (Germany)

    2009-03-01

    This paper presents the implementation of an analog optical phase-locked-loop with an offset frequency of about 20MHz between two lasers, where the detected light powers were of the order of 31 pW and 200 muW. The goal of this setup was the design and characterization of a photodiode transimpedance amplifier for application in LISA. By application of a transimpedance amplifier designed to have low noise and low power consumption, the phase noise between the two lasers was a factor of two above the shot noise limit down to 60mHz. The achievable phase sensitivity depends ultimately on the available power of the highly attenuated master laser and on the input current noise of the transimpedance amplifier of the photodetector. The limiting noise source below 60mHz was the analog phase measurement system that was used in this experiment. A digital phase measurement system that is currently under development at the AEI will be used in the near future. Its application should improve the sensitivity.

  14. Radiation pressure calibration and test mass reflectivities for LISA Pathfinder

    Science.gov (United States)

    Korsakova, Natalia; Kaune, Brigitte; LPF Collaboration

    2017-05-01

    This paper describes a series of experiments which were carried out during the main operations of LISA Pathfinder. These experiments were performed by modulating the power of the measurement and reference beams. In one series of experiments the beams were sequentially switched on and off. In the other series of experiments the powers of the beams were modulated within 0.1% and 1% of the constant power. These experiments use recordings of the total power measured on the photodiodes to infer the properties of the Optical Metrology System (OMS), such as reflectivities of the test masses and change of the photodiode efficiencies with time. In the first case the powers are back propagated from the different photodiodes to the same place on the optical bench to express the unknown quantities in the measurement with the complimentary photodiode measurements. They are combined in the way that the only unknown left is the test mass reflectivities. The second experiment compared two estimates of the force applied to the test masses due to the radiation pressure that appears because of the beam modulations. One estimate of the force is inferred from the measurements of the powers on the photodiodes and propagation of this measurement to the test masses. The other estimation of the force is done by calculating it from the change in the main scientific output of the instrument - differential displacement of the two test masses.

  15. Planning for chemical disasters at Point Lisas, Trinidad and Tobago

    International Nuclear Information System (INIS)

    Mathur, M.N.

    1995-01-01

    No major chemical disaster has taken place so far in Trinidad and Tobago. Even so, in view of the numerous hazards that the various chemical handling plants deal with at Point Lisas, the country has to be prepared to deal with chemical disasters. The country's emergency preparedness plan for chemical disasters aims to localize the emergency, if possible, eliminate it and minimize the effects of the accident on people and property. The hazards of ammonia, hydrogen, chlorine, hydrocarbons and methanol release can have devastating effects on the workers and the residents in the vicinity of the plants. The Emergency Plan identifies an Emergency Co-ordinating Officer who would take command of the off-site activities and coordinate the activities of Works Management, Local Authority, Police, Fire Services, Defence Force, Health Authority and Factory Inspectorate. Resources of fire fighting, medical treatment, telecommunications, waste management and public education have to be enhanced immediately. In the long term a new fire station and a new county hospital have to be built, some housing settlements have to be phased out and non-essential staff relocated

  16. LISA Pathfinder: An important first step towards a space-based gravitational wave observatory

    Science.gov (United States)

    Thorpe, James

    2017-08-01

    ESA's LISA Pathfinder mission was launched on Dec 3rd, 2015 and completed earlier this Summer. During this relatively short mission, Pathfinder at its two science payloads, Europe's LISA Technology Package and NASA's Disturbance Reduction System, demonstrated several techniques and technologies that enable development of a future space-based gravitational wave observatory. Most notably, Pathfinder demonstrated that the technique of drag-free flight could be utilized to place a test mass in near-perfect free-fall, with residual accelerations at the femto-g level in the milliHertz band. Additionally, technologies such as precision bonded optical structures for metrology, micropropulsion systems, and non-contact charge control, were successfully tested, retiring risk for LISA. In this talk, I will present an overview of Pathfinder's results to date and some perspective on how this success will be leveraged into realizing LISA.

  17. Report on the first round of the Mock LISA Data Challenges

    International Nuclear Information System (INIS)

    Arnaud, K A; Auger, G; Babak, S

    2007-01-01

    The Mock LISA Data Challenges (MLDCs) have the dual purpose of fostering the development of LISA data analysis tools and capabilities, and demonstrating the technical readiness already achieved by the gravitational-wave community in distilling a rich science payoff from the LISA data output. The first round of MLDCs has just been completed: nine challenges consisting of data sets containing simulated gravitational-wave signals produced either by galactic binaries or massive black hole binaries embedded in simulated LISA instrumental noise were released in June 2006 with deadline for submission of results at the beginning of December 2006. Ten groups have participated in this first round of challenges. All of the challenges had at least one entry which successfully characterized the signal to better than 95% when assessed via a correlation with phasing ambiguities accounted for. Here, we describe the challenges, summarize the results and provide a first critical assessment of the entries

  18. Stellar binary black holes in the LISA band: a new class of standard sirens

    Science.gov (United States)

    Del Pozzo, Walter; Sesana, Alberto; Klein, Antoine

    2018-04-01

    The recent Advanced LIGO detections of coalescing black hole binaries (BHBs) imply a large population of such systems emitting at milli-Hz frequencies, accessible to the Laser Interferometer Space Antenna (LISA). We show that these systems provide a new class of cosmological standard sirens. Direct LISA luminosity distance - Dl - measurements, combined with the inhomogeneous redshift - z - distribution of possible host galaxies provide an effective way to populate the Dl-z diagram at z arm-length, respectively.

  19. LISA extreme-mass-ratio inspiral events as probes of the black hole mass function

    International Nuclear Information System (INIS)

    Gair, Jonathan R.; Tang, Christopher; Volonteri, Marta

    2010-01-01

    One of the sources of gravitational waves for the proposed space-based gravitational wave detector, the Laser Interferometer Space Antenna (LISA), are the inspirals of compact objects into supermassive black holes in the centers of galaxies--extreme-mass-ratio inspirals (EMRIs). Using LISA observations, we will be able to measure the parameters of each EMRI system detected to very high precision. However, the statistics of the set of EMRI events observed by LISA will be more important in constraining astrophysical models than extremely precise measurements for individual systems. The black holes to which LISA is most sensitive are in a mass range that is difficult to probe using other techniques, so LISA provides an almost unique window onto these objects. In this paper we explore, using Bayesian techniques, the constraints that LISA EMRI observations can place on the mass function of black holes at low redshift. We describe a general framework for approaching inference of this type--using multiple observations in combination to constrain a parametrized source population. Assuming that the scaling of the EMRI rate with the black-hole mass is known and taking a black-hole distribution given by a simple power law, dn/dlnM=A 0 (M/M * ) α 0 , we find that LISA could measure the parameters to a precision of Δ(lnA 0 )∼0.08, and Δ(α 0 )∼0.03 for a reference model that predicts ∼1000 events. Even with as few as 10 events, LISA should constrain the slope to a precision ∼0.3, which is the current level of observational uncertainty in the low-mass slope of the black-hole mass function. We also consider a model in which A 0 and α 0 evolve with redshift, but find that EMRI observations alone do not have much power to probe such an evolution.

  20. Constraining stellar binary black hole formation scenarios with eLISA eccentricity measurements

    OpenAIRE

    Nishizawa, Atsushi; Sesana, Alberto; Berti, Emanuele; Klein, Antoine

    2016-01-01

    A space-based interferometer such as eLISA could observe few to few thousands progenitors of black hole binaries (BHBs) similar to those recently detected by Advanced LIGO. Gravitational radiation circularizes the orbit during inspiral, but some BHBs retain a measurable eccentricity at the low frequencies where eLISA is most sensitive. The eccentricity of a BHB carries precious information about its formation channel: BHBs formed in the field, in globular clusters, or close to a massive black...

  1. Optimal statistic for detecting gravitational wave signals from binary inspirals with LISA

    CERN Document Server

    Rogan, A

    2004-01-01

    A binary compact object early in its inspiral phase will be picked up by its nearly monochromatic gravitational radiation by LISA. But even this innocuous appearing candidate poses interesting detection challenges. The data that will be scanned for such sources will be a set of three functions of LISA's twelve data streams obtained through time-delay interferometry, which is necessary to cancel the noise contributions from laser-frequency fluctuations and optical-bench motions to these data streams. We call these three functions pseudo-detectors. The sensitivity of any pseudo-detector to a given sky position is a function of LISA's orbital position. Moreover, at a given point in LISA's orbit, each pseudo-detector has a different sensitivity to the same sky position. In this work, we obtain the optimal statistic for detecting gravitational wave signals, such as from compact binaries early in their inspiral stage, in LISA data. We also present how the sensitivity of LISA, defined by this optimal statistic, vari...

  2. Constraining stellar binary black hole formation scenarios with eLISA eccentricity measurements

    Science.gov (United States)

    Nishizawa, Atsushi; Sesana, Alberto; Berti, Emanuele; Klein, Antoine

    2017-03-01

    A space-based interferometer such as the evolved Laser Interferometer Space Antenna (eLISA) could observe a few to a few thousands of progenitors of black hole binaries (BHBs) similar to those recently detected by Advanced LIGO. Gravitational radiation circularizes the orbit during inspiral, but some BHBs retain a measurable eccentricity at the low frequencies where eLISA is the most sensitive. The eccentricity of a BHB carries precious information about its formation channel: BHBs formed in the field, in globular clusters, or close to a massive black hole (MBH) have distinct eccentricity distributions in the eLISA band. We generate mock eLISA observations, folding in measurement errors, and using a Bayesian model selection, we study whether eLISA measurements can identify the BHB formation channel. We find that a handful of observations would suffice to tell whether BHBs were formed in the gravitational field of an MBH. Conversely, several tens of observations are needed to tell apart field formation from globular cluster formation. A 5-yr eLISA mission with the longest possible armlength is desirable to shed light on BHB formation scenarios.

  3. Quantitative analysis of LISA pathfinder test-mass noise

    International Nuclear Information System (INIS)

    Ferraioli, Luigi; Congedo, Giuseppe; Hueller, Mauro; Vitale, Stefano; Hewitson, Martin; Nofrarias, Miquel; Armano, Michele

    2011-01-01

    LISA Pathfinder (LPF) is a mission aiming to test the critical technology for the forthcoming space-based gravitational-wave detectors. The main scientific objective of the LPF mission is to demonstrate test masses free falling with residual accelerations below 3x10 -14 m s -2 /√(Hz) at 1 mHz. Reaching such an ambitious target will require a significant amount of system optimization and characterization, which will in turn require accurate and quantitative noise analysis procedures. In this paper, we discuss two main problems associated with the analysis of the data from LPF: i) excess noise detection and ii) noise parameter identification. The mission is focused on the low-frequency region ([0.1, 10] mHz) of the available signal spectrum. In such a region, the signal is dominated by the force noise acting on test masses. At the same time, the mission duration is limited to 90 days and typical data segments will be 24 hours in length. Considering those constraints, noise analysis is expected to deal with a limited amount of non-Gaussian data, since the spectrum statistics will be far from Gaussian and the lowest available frequency is limited by the data length. In this paper, we analyze the details of the expected statistics for spectral data and develop two suitable excess noise estimators. One is based on the statistical properties of the integrated spectrum, the other is based on the Kolmogorov-Smirnov test. The sensitivity of the estimators is discussed theoretically for independent data, then the algorithms are tested on LPF synthetic data. The test on realistic LPF data allows the effect of spectral data correlations on the efficiency of the different noise excess estimators to be highlighted. It also reveals the versatility of the Kolmogorov-Smirnov approach, which can be adapted to provide reasonable results on correlated data from a modified version of the standard equations for the inversion of the test statistic. Closely related to excess noise

  4. Verification of time-delay interferometry techniques using the University of Florida LISA interferometry simulator

    Energy Technology Data Exchange (ETDEWEB)

    Mitryk, Shawn J; Wand, Vinzenz; Mueller, Guido, E-mail: smitryk@phys.ufl.ed, E-mail: mueller@phys.ufl.ed [Department of Physics, University of Florida, PO Box 118440, Gainesville, FL 32611-8440 (United States)

    2010-04-21

    Laser Interferometer Space Antenna (LISA) is a cooperative NASA/ESA mission proposed to directly measure gravitational waves (GW) in the frequency range from 30 muHz to 1 Hz with an optimal strain sensitivity of 10{sup -21}/sq root(Hz) at 3 mHz. LISA will utilize a modified Michelson interferometer to measure length changes of 40 pm/sq root(Hz) between drag-free proof masses located on three separate spacecraft (SC) separated by a distance of 5 Gm. The University of Florida has developed a hardware-in-the-loop simulator of the LISA constellation to verify the laser noise cancellation technique known as time-delay interferometry (TDI). We replicate the frequency stabilization of the laser on the local SC and the phase-locking of the lasers on the far SC. The laser photodetector beatnotes are electronically delayed, Doppler shifted and applied with a mock GW signal to simulate the laser link between the SC. The beatnotes are also measured with a LISA-like phasemeter and the data are used to extract the laser phase and residual phase-lock loop noise in post-processing through TDI. This uncovers the GW modulation signal buried under the laser noise. The results are then compared to the requirements defined by the LISA science collaboration.

  5. LISA Pathfinder test-mass charging during galactic cosmic-ray flux short-term variations

    Science.gov (United States)

    Grimani, C.; Fabi, M.; Lobo, A.; Mateos, I.; Telloni, D.

    2015-02-01

    Metal free-floating test masses aboard the future interferometers devoted to gravitational wave detection in space are charged by galactic and solar cosmic rays with energies \\gt 100 MeV/n. This process represents one of the main sources of noise in the lowest frequency band (\\lt 10-3 Hz) of these experiments. We study here the charging of the LISA Pathfinder (LISA-PF) gold-platinum test masses due to galactic cosmic-ray (GCR) protons and helium nuclei with the Fluka Monte Carlo toolkit. Projections of the energy spectra of GCRs during the LISA-PF operations in 2015 are considered. This work was carried out on the basis of the solar activity level and solar polarity epoch expected for LISA-PF. The effects of GCR short-term variations are evaluated here for the first time. Classical Forbush decreases, GCR variations induced by the Sun rotation, and fluctuations in the LISA-PF frequency bandwidth are discussed.

  6. Sensing and actuation system for the University of Florida Torsion Pendulum for LISA

    Science.gov (United States)

    Chilton, Andrew; Shelley, Ryan; Olatunde, Taiwo; Ciani, Giacomo; Conklin, John; Mueller, Guido

    2014-03-01

    Space-based gravitational wave detectors like LISA are a necessity for understanding the low-frequency portion of the gravitational universe. They use test masses (TMs) which are separated by Gm and are in free fall inside their respective spacecraft. Their relative distance is monitored with laser interferometry at the pm/rtHz level in the LISA band, ranging from 0.1 to 100 mHz. Each TM is enclosed in a housing that provides isolation, capacitive sensing, and electrostatic actuation capabilities. The electronics must both be sensitive at the 1 nm/rtHz level and not induce residual acceleration noise above the requirement for LISA Pathfinder (3*10-15 m/sec2Hz1/2at 3 mHz). Testing and developing this technology is one of the roles of the University of Florida Torsion Pendulum, the only US testbed for LISA-like gravitational reference sensor technology. Our implementation of the sensing system functions by biasing our hollow LISA-like TMs with a 100 kHz sine wave and coupling a pair surrounding electrodes as capacitors to a pair of preamps and a differential amplifier; all other processing is done digitally. Here we report on the design of, implementation of, and preliminary results from the UF Torsion Pendulum.

  7. Reducing tilt-to-length coupling for the LISA test mass interferometer

    Science.gov (United States)

    Tröbs, M.; Schuster, S.; Lieser, M.; Zwetz, M.; Chwalla, M.; Danzmann, K.; Fernández Barránco, G.; Fitzsimons, E. D.; Gerberding, O.; Heinzel, G.; Killow, C. J.; Perreur-Lloyd, M.; Robertson, D. I.; Schwarze, T. S.; Wanner, G.; Ward, H.

    2018-05-01

    Objects sensed by laser interferometers are usually not stable in position or orientation. This angular instability can lead to a coupling of angular tilt to apparent longitudinal displacement—tilt-to-length coupling (TTL). In LISA this is a potential noise source for both the test mass interferometer and the long-arm interferometer. We have experimentally investigated TTL coupling in a setup representative for the LISA test mass interferometer and used this system to characterise two different imaging systems (a two-lens design and a four-lens design) both designed to minimise TTL coupling. We show that both imaging systems meet the LISA requirement of  ±25 μm rad‑1 for interfering beams with relative angles of up to  ±300 μrad. Furthermore, we found a dependency of the TTL coupling on beam properties such as the waist size and location, which we characterised both theoretically and experimentally.

  8. In-flight thermal experiments for LISA Pathfinder: Simulating temperature noise at the Inertial Sensors

    International Nuclear Information System (INIS)

    Armano, M; Audley, H; Born, M; Danzmann, K; Diepholz, I; Auger, G; Binetruy, P; Baird, J; Bortoluzzi, D; Brandt, N; Fitzsimons, E; Bursi, A; Caleno, M; Cavalleri, A; Cesarini, A; Dolesi, R; Ferroni, V; Cruise, M; Dunbar, N; Ferraioli, L

    2015-01-01

    Thermal Diagnostics experiments to be carried out on board LISA Pathfinder (LPF) will yield a detailed characterisation of how temperature fluctuations affect the LTP (LISA Technology Package) instrument performance, a crucial information for future space based gravitational wave detectors as the proposed eLISA. Amongst them, the study of temperature gradient fluctuations around the test masses of the Inertial Sensors will provide as well information regarding the contribution of the Brownian noise, which is expected to limit the LTP sensitivity at frequencies close to 1 mHz during some LTP experiments. In this paper we report on how these kind of Thermal Diagnostics experiments were simulated in the last LPF Simulation Campaign (November, 2013) involving all the LPF Data Analysis team and using an end-to-end simulator of the whole spacecraft. Such simulation campaign was conducted under the framework of the preparation for LPF operations. (paper)

  9. Advancements of the Lightweight Integrated Solar Array and Transceiver (LISA-T) Small Spacecraft System

    Science.gov (United States)

    Lockett, Tiffany Russell; Martinez, Armando; Boyd, Darren; SanSouice, Michael; Farmer, Brandon; Schneider, Todd; Laue, Greg; Fabisinski, Leo; Johnson, Les; Carr, John A.

    2015-01-01

    This paper describes recent advancements of the Lightweight Integrated Solar Array and Transceiver (LISA-T) currently being developed at NASA's Marshall Space Flight Center. The LISA-T array comprises a launch stowed, orbit deployed structure on which thin-film photovoltaic (PV) and antenna devices are embedded. The system provides significant electrical power generation at low weights, high stowage efficiency, and without the need for solar tracking. Leveraging high-volume terrestrial-market PVs also gives the potential for lower array costs. LISA-T is addressing the power starvation epidemic currently seen by many small-scale satellites while also enabling the application of deployable antenna arrays. Herein, an overview of the system and its applications are presented alongside sub-system development progress and environmental testing plans.

  10. The Mock LISA Data Challenges: from challenge 3 to challenge 4

    International Nuclear Information System (INIS)

    Babak, Stanislav; Petiteau, Antoine; Robinson, Emma L; Baker, John G; McWilliams, Sean T; Arnaud, Keith A; Benacquista, Matthew J; Cornish, Neil J; Adams, Matt; Larson, Shane L; Mandel, Ilya; Porter, Edward K; Vallisneri, Michele; Cutler, Curt; Vecchio, Alberto; Blaut, Arkadiusz; Bridges, Michael; Feroz, Farhan; Cohen, Michael; Gair, Jonathan R.

    2010-01-01

    The Mock LISA Data Challenges are a program to demonstrate LISA data-analysis capabilities and to encourage their development. Each round of challenges consists of one or more datasets containing simulated instrument noise and gravitational waves from sources of undisclosed parameters. Participants analyze the datasets and report best-fit solutions for the source parameters. Here we present the results of the third challenge, issued in April 2008, which demonstrated the positive recovery of signals from chirping galactic binaries, from spinning supermassive-black-hole binaries (with optimal SNRs between ∼10 and 2000), from simultaneous extreme-mass-ratio inspirals (SNRs of 10-50), from cosmic-string-cusp bursts (SNRs of 10-100), and from a relatively loud isotropic background with Ω gw (f) ∼ 10 -11 , slightly below the LISA instrument noise.

  11. The Mock LISA Data Challenges: from challenge 3 to challenge 4

    Energy Technology Data Exchange (ETDEWEB)

    Babak, Stanislav; Petiteau, Antoine; Robinson, Emma L [Max-Planck-Institut fuer Gravitationsphysik (Albert-Einstein-Institut), Am Muehlenberg 1, D-14476 Golm bei Potsdam (Germany); Baker, John G; McWilliams, Sean T; Arnaud, Keith A [Gravitational Astrophysics Laboratory, NASA Goddard Space Flight Center, 8800 Greenbelt Rd, Greenbelt, MD 20771 (United States); Benacquista, Matthew J [Center for Gravitational Wave Astronomy, University of Texas at Brownsville, Brownsville, TX 78520 (United States); Cornish, Neil J; Adams, Matt [Department of Physics, Montana State University, Bozeman, MT 59717 (United States); Larson, Shane L [Department of Physics, Utah State University, Logan, UT 84322 (United States); Mandel, Ilya [Department of Physics and Astronomy, Northwestern University, Evanston, IL (United States); Porter, Edward K [APC, UMR 7164, University Paris 7 Denis Diderot, 10, rue Alice Domon et Leonie Duquet, 75025 Paris Cedex 13 (France); Vallisneri, Michele; Cutler, Curt [Jet Propulsion Laboratory, California Institute of Technology, Pasadena, CA 91109 (United States); Vecchio, Alberto [School of Physics and Astronomy, University of Birmingham, Edgbaston, Birmingham B152TT (United Kingdom); Blaut, Arkadiusz [Institute of Theoretical Physics, University of Wroclaw, Wroclaw (Poland); Bridges, Michael; Feroz, Farhan [Astrophysics Group, Cavendish Laboratory, University of Cambridge, Cambridge CB30HE (United Kingdom); Cohen, Michael [Theoretical Astrophysics, California Institute of Technology, Pasadena, CA 91125 (United States); Gair, Jonathan R., E-mail: Michele.Vallisneri@jpl.nasa.go [Institute of Astronomy, University of Cambridge, Cambridge CB30HA (United Kingdom)

    2010-04-21

    The Mock LISA Data Challenges are a program to demonstrate LISA data-analysis capabilities and to encourage their development. Each round of challenges consists of one or more datasets containing simulated instrument noise and gravitational waves from sources of undisclosed parameters. Participants analyze the datasets and report best-fit solutions for the source parameters. Here we present the results of the third challenge, issued in April 2008, which demonstrated the positive recovery of signals from chirping galactic binaries, from spinning supermassive-black-hole binaries (with optimal SNRs between approx10 and 2000), from simultaneous extreme-mass-ratio inspirals (SNRs of 10-50), from cosmic-string-cusp bursts (SNRs of 10-100), and from a relatively loud isotropic background with OMEGA{sub gw}(f) approx 10{sup -11}, slightly below the LISA instrument noise.

  12. LISA technologies in new light: exploring alternatives for charge management and optical bench construction

    Science.gov (United States)

    Ciani, Giacomo; Chilton, Andrew; Olatunde, Taiwo; Apple, Stephen; Conklin, John W.; Mueller, Guido

    2015-08-01

    A LISA-like gravitational wave observatory is the choice candidate for ESA's L3 large mission scheduled to launch in 2034. The LISA Test Package (LTP) mission will launch later this year and test many critical technologies needed for such an observatory, among which are picometer interferometry in space and UV charge management of the Test Mass (TM). The design of these subsystems has been frozen many years ago during the final formulation of the LTP mission; since then, the LISA mission concept has evolved and new technologies have become available, making it possible to re-think the way these subsystem are implemented. With the final formulation of the L3 mission still years in the future and the LTP results expected in about one year, now is an ideal time look for areas of possible improvement and explore alternative implementations that can enhance performance, reduce costs or mitigate risks.Recently developed UV LED are lighter, cheaper and more powerful than traditional mercury lamps; in addition, their fast response time can be used to implement AC discharge techniques that can save even more space and power, and provide a more precise control of the charge.The most recent iteration of the mission baseline design allows for eliminating some of the optical components initially deemed essential; paired with the use of polarization multiplexing, this permits a redesign of the optical bench that simplifies the layout and enables a modular approach to machining and assembly, thus reducing the risks and costs associated with the current monolithic design without compromising the picometer stability of the optical path.Leveraging on extensive previous experience with LISA interferometry and the availability of a torsion pendulum-based LISA test-bed, the University of Florida LISA group is working at developing, demonstrating and optimizing both these technologies. I will describe the most recent advancements and results.

  13. 75 FR 47203 - Airworthiness Directives; McDonnell Douglas Corporation Model MD-11 and MD-11F Airplanes Equipped...

    Science.gov (United States)

    2010-08-05

    ... Airworthiness Directives; McDonnell Douglas Corporation Model MD- 11 and MD-11F Airplanes Equipped With General... Sec. 39.13 by adding the following new AD: 2010-16-03 McDonnell Douglas Corporation: Amendment 39... applies to McDonnell Douglas Corporation Model MD-11 and MD-11F airplanes, certified in any category...

  14. MONA, LISA and VINCI Soon Ready to Travel to Paranal

    Science.gov (United States)

    2000-11-01

    First Instruments for the VLT Interferometer Summary A few months from now, light from celestial objects will be directed for the first time towards ESO's Very Large Telescope Interferometer (VLTI) at the Paranal Observatory (Chile). During this "First Light" event and the subsequent test phase, the light will be recorded with a special test instrument, VINCI (VLT INterferometer Commissioning Instrument). The main components of this high-tech instrument are aptly named MONA (a system that combines the light beams from several telescopes by means of optical fibers) and LISA (the infrared camera). VINCI was designed and constructed within a fruitful collaboration between ESO and several research institutes and industrial companies in France and Germany . It is now being assembled at the ESO Headquarters in Garching (Germany) and will soon be ready for installation at the telescope on Paranal. With the VLTI and VINCI, Europe's astronomers are now entering the first, crucial phase of an exciting scientific and technology venture that will ultimately put the world's most powerful optical/IR interferometric facility in their hands . PR Photo 31/00 : VINCI during tests at the ESO Headquarters in Garching. The VLT Interferometer (VLTI) ESO Press Photo 31/00 ESO Press Photo 31/00 [Preview; JPEG: 400 x 301; 43k] [Normal; JPEG: 800 x 602;208xk] [Full-Res; JPEG: 1923 x 1448; 2.2Mb] PR Photo 31/00 shows the various components of the complex VINCI instrument for the VLT Interferometer , during the current tests at the Optical Laboratory at the ESO Headquarters in Garching (Germany). It will later be installed in "clean-room" conditions within the Interferometric Laboratory at the Paranal Observatory. This electronic photo was obtained for documentary purposes. VINCI (VLT INterferometer Commissioning Instrument) is the "First Light" instrument for the Very Large Telescope Interferometer (VLTI) at the Paranal Observatory (Chile). Early in 2001, it will be used for the first tests

  15. LTP - LISA technology package: Development challenges of a spaceborne fundamental physics experiment

    International Nuclear Information System (INIS)

    Gerndt, R

    2009-01-01

    The LISA Technology Package (LTP) is the main payload onboard the LISA Pathfinder Spacecraft. The LTP Instrument together with the Drag-Free Attitude Control System (DFACS) and the respective LTP and DFACS operational software forms the LTP Experiment. It is completed by the FEEPs of the LPF spacecraft that are controlled by DFACS in order to control the spacecraft's attitude along with the experiment's needs. This article concentrates on aspects of the Industrial development of the LTP Instrument items and on essential performance issues of LTP. Examples of investigations on specific issue will highlight the kind of special problems to be solved for LTP in close cooperation with the Scientific Community.

  16. Acoustic waves and the detectability of first-order phase transitions by eLISA

    Science.gov (United States)

    Weir, David J.

    2017-05-01

    In various extensions of the Standard Model it is possible that the electroweak phase transition was first order. This would have been a violent process, involving the formation of bubbles and associated shock waves. Not only would the collision of these bubbles and shock waves be a detectable source of gravitational waves, but persistent acoustic waves could enhance the signal and improve prospects of detection by eLISA. I summarise the results of a recent campaign to model such a phase transition based on large-scale hydrodynamical simulations, and its implications for the eLISA mission.

  17. From LPF to eLISA: new approach in payload software

    Science.gov (United States)

    Gesa, Ll.; Martin, V.; Conchillo, A.; Ortega, J. A.; Mateos, I.; Torrents, A.; Lopez-Zaragoza, J. P.; Rivas, F.; Lloro, I.; Nofrarias, M.; Sopuerta, CF.

    2017-05-01

    eLISA will be the first observatory in space to explore the Gravitational Universe. It will gather revolutionary information about the dark universe. This implies a robust and reliable embedded control software and hardware working together. With the lessons learnt with the LISA Pathfinder payload software as baseline, we will introduce in this short article the key concepts and new approaches that our group is working on in terms of software: multiprocessor, self-modifying-code strategies, 100% hardware and software monitoring, embedded scripting, Time and Space Partition among others.

  18. Doing Science with eLISA: Astrophysics and Cosmology in the Millihertz Regime

    Science.gov (United States)

    Amaro, Seoane, Pau; Aoudia, Sofiane; Babak, Stanislav; Binetruy, Pierre; Berti, Amanuele; Bohe, Alejandro; Caprini, Chiara; Colpi, Monica; Cornish, Neil J.; Danzmann, Karsten; hide

    2012-01-01

    This document introduces the exciting and fundamentally new science and astronomy that the European New Gravitational Wave Observatory (NGO) mission (derived from the previous LISA proposal) will deliver. The mission (which we will refer to by its informal name eLISA ) will survey for the first time the low-frequency gravitational wave band (about 0.1 mHz to 1 Hz), with sufficient sensitivity to detect interesting individual astrophysical sources out to z = 15. The measurements described here will address the basic scientific goals that have been captured in ESA s New Gravitational Wave Observatory Science Requirements Document ; they are presented here so that the wider scientific community can have access to them. The eLISA mission will discover and study a variety of cosmic events and systems with high sensitivity: coalescences of massive black holes binaries, brought together by galaxy mergers; mergers of earlier, less-massive black holes during the epoch of hierarchical galaxy and black-hole growth; stellar-mass black holes and compact stars in orbits just skimming the horizons of massive black holes in galactic nuclei of the present era; extremely compact white dwarf binaries in our Galaxy, a rich source of information about binary evolution and about future Type Ia supernovae; and possibly most interesting of all, the uncertain and unpredicted sources, for example relics of inflation and of the symmetry-breaking epoch directly after the Big Bang. eLISA s measurements will allow detailed studies of these signals with high signal-to-noise ratio, addressing most of the key scientific questions raised by ESA s Cosmic Vision programme in the areas of astrophysics and cosmology. They will also provide stringent tests of general relativity in the strong-field dynamical regime, which cannot be probed in any other way. This document not only describes the science but also gives an overview on the mission design and orbits. LISA s heritage in the eLISA design will be

  19. eLISA eccentricity measurements as tracers of binary black hole formation

    OpenAIRE

    Nishizawa, Atsushi; Berti, Emanuele; Klein, Antoine; Sesana, Alberto

    2016-01-01

    Up to hundreds of black hole binaries individually resolvable by eLISA will coalesce in the Advanced LIGO/Virgo band within ten years, allowing for multi-band gravitational wave observations. Binaries formed via dynamical interactions in dense star clusters are expected to have eccentricities $e_0\\sim 10^{-3}$-$10^{-1}$ at the frequencies $f_0=10^{-2}$ Hz where eLISA is most sensitive, while binaries formed in the field should have negligible eccentricity in both frequency bands. We estimate ...

  20. MD2190: Q" Stabilization during injection

    CERN Document Server

    Schenk, Michael; Li, Kevin Shing Bruce; Malina, Lukas; Metral, Elias; Tomas Garcia, Rogelio; CERN. Geneva. ATS Department

    2018-01-01

    This MD is a follow-up study of MD1831, where single bunches were stabilized against impedance-driven instabilities at 6.5 TeV in the LHC with Q''. The goals are (i) to explore whether an amplitude detuning free Q'' knob can be implemented at injection energy, and (ii) whether Q'' can provide beam stability at injection, where the beams suffer mostly from electron cloud effects. Ideally, this would relax the use of the Landau octupoles and may help in preserving the beam quality by reducing dynamic aperture limitations originating from the octupoles. The MD has been split into two parts: First, optics corrections were put in place to minimize beta-beating and linear coupling introduced by the knobs. The corrections were achieved by means of orbit bumps and skew quadrupole knobs. Machine safety was then validated with loss maps. While the betatron loss maps were approved, the off-momentum maps showed a priori unexpected losses in several arcs and the MD was stopped at this point for reasons of machine protecti...

  1. MD2725: 16L2 aperture measurement

    CERN Document Server

    Mirarchi, Daniele; Rossi, Roberto; CERN. Geneva. ATS Department

    2018-01-01

    Dumps induced by sudden increase of losses in the half-cell 16L2 have been a serious machine limitation during the 2017 run. The aim of this MD was to perform local aperture measurements in order to assess differences after the beam screen regeneration, compared to first measurements in 2017.

  2. MD-11 PCA - Research flight team photo

    Science.gov (United States)

    1995-01-01

    On Aug. 30, 1995, a the McDonnell Douglas MD-11 transport aircraft landed equipped with a computer-assisted engine control system that has the potential to increase flight safety. In landings at NASA Dryden Flight Research Center, Edwards, California, on August 29 and 30, the aircraft demonstrated software used in the aircraft's flight control computer that essentially landed the MD-11 without a need for the pilot to manipulate the flight controls significantly. In partnership with McDonnell Douglas Aerospace (MDA), with Pratt & Whitney and Honeywell helping to design the software, NASA developed this propulsion-controlled aircraft (PCA) system following a series of incidents in which hydraulic failures resulted in the loss of flight controls. This new system enables a pilot to operate and land the aircraft safely when its normal, hydraulically-activated control surfaces are disabled. This August 29, 1995, photo shows the MD-11 team. Back row, left to right: Tim Dingen, MDA pilot; John Miller, MD-11 Chief pilot (MDA); Wayne Anselmo, MD-11 Flight Test Engineer (MDA); Gordon Fullerton, PCA Project pilot; Bill Burcham, PCA Chief Engineer; Rudey Duran, PCA Controls Engineer (MDA); John Feather, PCA Controls Engineer (MDA); Daryl Townsend, Crew Chief; Henry Hernandez, aircraft mechanic; Bob Baron, PCA Project Manager; Don Hermann, aircraft mechanic; Jerry Cousins, aircraft mechanic; Eric Petersen, PCA Manager (Honeywell); Trindel Maine, PCA Data Engineer; Jeff Kahler, PCA Software Engineer (Honeywell); Steve Goldthorpe, PCA Controls Engineer (MDA). Front row, left to right: Teresa Hass, Senior Project Management Analyst; Hollie Allingham (Aguilera), Senior Project Management Analyst; Taher Zeglum, PCA Data Engineer (MDA); Drew Pappas, PCA Project Manager (MDA); John Burken, PCA Control Engineer.

  3. Exploring intentions of physician-scientist trainees: factors influencing MD and MD/PhD interest in research careers.

    Science.gov (United States)

    Kwan, Jennifer M; Daye, Dania; Schmidt, Mary Lou; Conlon, Claudia Morrissey; Kim, Hajwa; Gaonkar, Bilwaj; Payne, Aimee S; Riddle, Megan; Madera, Sharline; Adami, Alexander J; Winter, Kate Quinn

    2017-07-11

    Prior studies have described the career paths of physician-scientist candidates after graduation, but the factors that influence career choices at the candidate stage remain unclear. Additionally, previous work has focused on MD/PhDs, despite many physician-scientists being MDs. This study sought to identify career sector intentions, important factors in career selection, and experienced and predicted obstacles to career success that influence the career choices of MD candidates, MD candidates with research-intense career intentions (MD-RI), and MD/PhD candidates. A 70-question survey was administered to students at 5 academic medical centers with Medical Scientist Training Programs (MSTPs) and Clinical and Translational Science Awards (CTSA) from the NIH. Data were analyzed using bivariate or multivariate analyses. More MD/PhD and MD-RI candidates anticipated or had experienced obstacles related to balancing academic and family responsibilities and to balancing clinical, research, and education responsibilities, whereas more MD candidates indicated experienced and predicted obstacles related to loan repayment. MD/PhD candidates expressed higher interest in basic and translational research compared to MD-RI candidates, who indicated more interest in clinical research. Overall, MD-RI candidates displayed a profile distinct from both MD/PhD and MD candidates. MD/PhD and MD-RI candidates experience obstacles that influence their intentions to pursue academic medical careers from the earliest training stage, obstacles which differ from those of their MD peers. The differences between the aspirations of and challenges facing MD, MD-RI and MD/PhD candidates present opportunities for training programs to target curricula and support services to ensure the career development of successful physician-scientists.

  4. Sky Localization of Complete Inspiral-Merger-Ringdown Signals for Nonspinning Black Hole Binaries with LISA

    Science.gov (United States)

    McWilliams, Sean T.; Lang, Ryan N.; Baker, John G.; Thorpe, James Ira

    2011-01-01

    We investigate the capability of LISA to measure the sky position of equal-mass, nonspinning black hole binaries, including for the first time the entire inspiral-merger-ringdown signal, the effect of the LISA orbits, and the complete three-channel LISA response. For an ensemble of systems near the peak of LISA's sensitivity band, with total rest mass of 2 x l0(exp 6) Stellar Mass at a redshift of z = 1 with random orientations and sky positions, we find median sky localization errors of approximately approx. 3 arcminutes. This is comparable to the field of view of powerful electromagnetic telescopes, such as the James Webb Space Telescope, that could be used to search for electromagnetic signals associated with merging black holes. We investigate the way in which parameter errors decrease with measurement time, focusing specifically on the additional information provided during the merger-ringdown segment of the signal. We find that this information improves all parameter estimates directly, rather than through diminishing correlations with any subset of well-determined parameters.

  5. Estudo bibliométrico do descritor “Ergonomia” na base LISA

    Directory of Open Access Journals (Sweden)

    Eliana Maria dos Santos Bahia

    2011-03-01

    Full Text Available Objetivo: O estudo analisa a produção científica sobre ergonomia utilizando a base de dados Library and Information Science Abstracts (LISA. A base de dados LISA, iniciada em 1969, mantém sua cobertura temática na área de Biblioteconomia e Ciência da Informação.Método: No estudo utilizou-se o método da bibliometria aplicada para verificar a produção científica indexada.Resultados: Entre os resultados da busca de termos indexados na base de dados LISA, encontraram-se 503 artigos com o termo “Ergonomic”; 352 artigos, com a expressão “Design”; 111 artigos com o descritor “Systems”; 110 artigos com o termo “Work”; e , 98 artigos com o termo “Evaluation”. Dentre os 34 títulos de periódicos, 4 títulos cobrem 79% dos artigos que tratam sobre Ergonomia na base LISA. Os demais 30 títulos de periódicos cobrem 21% dos artigos indexados sob essa temática.Conclusões: O presente estudo bibliométrico oferece possibilita um panorama de como a ergonomia é percebida na área da Biblioteconomia e Ciência da Informação.

  6. LISA detection of massive black hole binaries: imprint of seed populations and extreme recoils

    International Nuclear Information System (INIS)

    Sesana, A; Volonteri, M; Haardt, F

    2009-01-01

    All the physical processes involved in the formation, merging and accretion history of massive black holes along the hierarchical build-up of cosmic structures are likely to leave an imprint on the gravitational waves detectable by future space-borne missions, such as LISA. We report here the results of recent studies, carried out by means of dedicated simulations of black hole build-up, aiming at understanding the impact on LISA observations of two ingredients that are crucial in every massive black hole formation scenario, namely: (i) the nature and abundance of the first black hole seeds and (ii) the large gravitational recoils following the merger of highly spinning black holes. We predict LISA detection rates spanning two orders of magnitude, in the range 3-300 events per year, depending on the detail of the assumed massive black hole seed model. On the other hand, large recoil velocities do not dramatically compromise the efficiency of LISA observations. The number of detections may drop substantially (by ∼60%), in scenarios characterized by abundant light seeds, but if seeds are already massive and/or relatively rare, the detection rate is basically unaffected.

  7. Numerical code to determine the particle trapping region in the LISA machine

    International Nuclear Information System (INIS)

    Azevedo, M.T. de; Raposo, C.C. de; Tomimura, A.

    1984-01-01

    A numerical code is constructed to determine the trapping region in machine like LISA. The variable magnetic field is two deimensional and is coupled to the Runge-Kutta through the Tchebichev polynomial. Various particle orbits including particle interactions were analysed. Beside this, a strong electric field is introduced to see the possible effects happening inside the plasma. (Author) [pt

  8. Interpolation of the magnetic field at the test masses in eLISA

    International Nuclear Information System (INIS)

    Mateos, I; Díaz-Aguiló, M; Ramos-Castro, J; García-Berro, E; Lobo, A

    2015-01-01

    A feasible design for a magnetic diagnostics subsystem for eLISA will be based on that of its precursor mission, LISA Pathfinder. Previous experience indicates that magnetic field estimation at the positions of the test masses has certain complications. This is due to two reasons. The first is that magnetometers usually back-act due to their measurement principles (i.e., they also create their own magnetic fields), while the second is that the sensors selected for LISA Pathfinder have a large size, which conflicts with space resolution and with the possibility of having a sufficient number of them to properly map the magnetic field around the test masses. However, high-sensitivity and small-sized sensors that significantly mitigate the two aforementioned limitations exist, and have been proposed to overcome these problems. Thus, these sensors will be likely selected for the magnetic diagnostics subsystem of eLISA. Here we perform a quantitative analysis of the new magnetic subsystem, as it is currently conceived, and assess the feasibility of selecting these sensors in the final configuration of the magnetic diagnostic subsystem. (paper)

  9. Modulation of LISA free-fall orbits due to the Earth-Moon system

    Energy Technology Data Exchange (ETDEWEB)

    Cerdonio, Massimo; Marzari, Francesco [Department of Physics, University of Padova and INFN Padova, via Marzolo 8, I-35131 Padova (Italy); De Marchi, Fabrizio [Department of Physics, University of Trento and INFN Trento, I-38100 Povo (Trento) (Italy); De Pietri, Roberto [Department of Physics, University of Parma and INFN Parma I-43100 Parma (Italy); Jetzer, Philippe [Institute of Theoretical Physics, University of Zuerich, Winterhurerstrasse 190, 8057 Zuerich (Switzerland); Mazzolo, Giulio [Max Planck Institut fuer Gravitationsphysik, Callinstrasse 38, 30167 Hannover (Germany); Ortolan, Antonello [INFN Laboratori Nazionali di Legnaro, Viale dell' Universita 35020 Legnaro (Padova) (Italy); Sereno, Mauro, E-mail: fdemarchi@science.unitn.i [Dipartimento di Fisica, Politecnico di Torino, Corso Duca degli Abruzzi 24, 10129 Torino (Italy)

    2010-08-21

    We calculate the effect of the Earth-Moon (EM) system on the free-fall motion of LISA test masses. We show that the periodic gravitational pulling of the EM system induces a resonance with fundamental frequency 1 yr{sup -1} and a series of periodic perturbations with frequencies equal to integer harmonics of the synodic month ({approx_equal} 3.92 x 10{sup -7} Hz). We then evaluate the effects of these perturbations (up to the 6th harmonics) on the relative motions between each test mass couple, finding that they range between 3 mm and 10 pm for the 2nd and 6th harmonic, respectively. If we take the LISA sensitivity curve, as extrapolated down to 10{sup -6} Hz in Bender (2003 Class. Quantum Grav. 20 301-10), we obtain that a few harmonics of the EM system can be detected in the Doppler data collected by the LISA space mission. This suggests that the EM system gravitational near field could provide an additional crosscheck to the calibration of LISA, as extended to such low frequencies.

  10. Modulation of LISA free-fall orbits due to the Earth-Moon system

    International Nuclear Information System (INIS)

    Cerdonio, Massimo; Marzari, Francesco; De Marchi, Fabrizio; De Pietri, Roberto; Jetzer, Philippe; Mazzolo, Giulio; Ortolan, Antonello; Sereno, Mauro

    2010-01-01

    We calculate the effect of the Earth-Moon (EM) system on the free-fall motion of LISA test masses. We show that the periodic gravitational pulling of the EM system induces a resonance with fundamental frequency 1 yr -1 and a series of periodic perturbations with frequencies equal to integer harmonics of the synodic month (≅ 3.92 x 10 -7 Hz). We then evaluate the effects of these perturbations (up to the 6th harmonics) on the relative motions between each test mass couple, finding that they range between 3 mm and 10 pm for the 2nd and 6th harmonic, respectively. If we take the LISA sensitivity curve, as extrapolated down to 10 -6 Hz in Bender (2003 Class. Quantum Grav. 20 301-10), we obtain that a few harmonics of the EM system can be detected in the Doppler data collected by the LISA space mission. This suggests that the EM system gravitational near field could provide an additional crosscheck to the calibration of LISA, as extended to such low frequencies.

  11. Playing Harry Potter: Essays and interviews on fandom and performance, edited by Lisa S. Brenner

    Directory of Open Access Journals (Sweden)

    Abigail De Kosnik

    2016-09-01

    Full Text Available Lisa S. Brenner, editor. Playing Harry Potter: Essays and interviews on fandom and performance. Jefferson, NC: McFarland, 2015, paperback, $29.95 (238p ISBN 978-0-7864-9657-0; e-book $14.43 (5374 KB ISBN 978-1-4766-2136-4, ASIN B012E9G0R6.

  12. PREFACE: Proceedings of the 7th International LISA Symposium, Barcelona, Spain, 16-20 June 2008

    Science.gov (United States)

    Lobo, Alberto; Sopuerta, Carlos F.

    2009-07-01

    In June 2006 the LISA International Science Team (LIST) accepted the bid presented by the Institut d'Estudis Espacials de Catalunya (IEEC) to host the 7th International LISA Symposium. This was during its 11th meeting at the University of Maryland, just before the 6th edition of the Symposium started in NASA's Goddard Space Flight Center. The 7th International LISA Symposium took place at the city of Barcelona, Spain, from 16-20 June 2008, in the premises of CosmoCaixa, a modern Science Museum located in the hills near Tibidabo. Almost 240 delegates registered for the event, a record breaking figure compared to previous editions of the Symposium. Many of the most renowned world experts in LISA, Gravitational Wave Science, and Astronomy, as well as Engineers, attended LISA 7 and produced state-of-the-art presentations, while everybody benefited from the opportunity to have live discussions during the week in a friendly environment. The programme included 31 invited plenary lectures in the mornings, and 8 parallel sessions in the afternoons. These were classified into 7 major areas of research: LISA Technology, LISA PathFinder, LISA PathFinder Data Analysis, LISA Data Analysis, Gravitational Wave sources, Cosmology and Fundamental Physics with LISA and Other Gravitational Wave Detectors. 138 abstracts for communications were received, of which a selection was made by the session convenors which would fit time constraints. Up to 63 posters completed the scientific programme. More details on the programme, including some of the talks, can be found at the Symposium website: http://www.ice.cat/research/LISA_Symposium. There was however a remarkable add-on: Professor Clifford Will delivered a startling presentation to the general public, who completely filled the Auditori—the main Conference Room, 320 seats—and were invited to ask questions to the speaker who had boldly guided them through the daunting world of Black Holes, Waves of Gravity, and other Warped Ideas of

  13. Massive black-hole binary inspirals: results from the LISA parameter estimation taskforce

    International Nuclear Information System (INIS)

    Arun, K G; Babak, Stas; Porter, Edward K; Sintes, Alicia M; Berti, Emanuele; Cutler, Curt; Cornish, Neil; Gair, Jonathan; Hughes, Scott A; Lang, Ryan N; Iyer, Bala R; Sinha, Siddhartha; Mandel, Ilya; Sathyaprakash, Bangalore S; Van Den Broeck, Chris; Trias, Miquel; Volonteri, Marta

    2009-01-01

    The LISA Parameter Estimation Taskforce was formed in September 2007 to provide the LISA Project with vetted codes, source distribution models and results related to parameter estimation. The Taskforce's goal is to be able to quickly calculate the impact of any mission design changes on LISA's science capabilities, based on reasonable estimates of the distribution of astrophysical sources in the universe. This paper describes our Taskforce's work on massive black-hole binaries (MBHBs). Given present uncertainties in the formation history of MBHBs, we adopt four different population models, based on (i) whether the initial black-hole seeds are small or large and (ii) whether accretion is efficient or inefficient at spinning up the holes. We compare four largely independent codes for calculating LISA's parameter-estimation capabilities. All codes are based on the Fisher-matrix approximation, but in the past they used somewhat different signal models, source parametrizations and noise curves. We show that once these differences are removed, the four codes give results in extremely close agreement with each other. Using a code that includes both spin precession and higher harmonics in the gravitational-wave signal, we carry out Monte Carlo simulations and determine the number of events that can be detected and accurately localized in our four population models.

  14. Apple fruit acidity is genetically diversified by natural variations in three hierarchical epistatic genes MdSAUR37, MdPP2CH and MdALMTII.

    Science.gov (United States)

    Jia, Dongjie; Shen, Fei; Wang, Yi; Wu, Ting; Xu, Xuefeng; Zhang, Xinzhong; Han, Zhenhai

    2018-05-11

    Many efforts have been made to map quantitative trait loci (QTLs) to facilitate practical marker-assisted selection (MAS) in plants. In the present study, we identified four genome-wide major QTLs responsible for apple fruit acidity by MapQTL and BSA-seq analyses using two independent pedigree-based populations. Candidate genes were screened in major QTL regions, and three functional gene markers, including a non-synonymous A/G single nucleotide polymorphism (SNP) in the coding region of MdPP2CH, a 36-bp insertion in the promoter of MdSAUR37, and a previously reported SNP in MdALMTII, were validated to influence the malate content of apple fruits. In addition, MdPP2CH inactivated three vacuolar H + -ATPases (MdVHA-A3, MdVHA-B2 and MdVHA-D2) and one aluminium-activated malate transporter (MdALMTII) via dephosphorylation and negatively influenced fruit malate accumulation. The dephosphotase activity of MdPP2CH was suppressed by MdSAUR37, which implied a higher hierarchy of genetic interaction. Therefore, the MdSAUR37/MdPP2CH/MdALMTII chain cascaded hierarchical epistatic genetic effects to precisely determine apple fruit malate content. An A/G SNP (-1010) on MdMYB44 promoter region from a major QTL (qtl08.1) was closely associated with fruit malate content. The predicted phenotype values (PPVs) were estimated using the tentative genotype values of the gene markers, and the PPVs were significantly correlated with the observed phenotype values. Our findings provide an insight into plant genome-based selection in apples and will aid in conducting research to understand the physiological fundamentals of quantitative genetics. This article is protected by copyright. All rights reserved. This article is protected by copyright. All rights reserved.

  15. MD on UFOs at MKIs and MKQs

    CERN Document Server

    Baer, T; Bartmann, W; Bracco, C; Carlier, E; Dehning, B; Garrel, N; Goddard, B; Jackson, S; Jimenez, M; Kain, V; Mertens, V; Misiowiec, M; Nordt, A; Papotti, G; Uythoven, J; Wenninger, J; Zerlauth, M; Zamantzas, C; Zimmermann, F

    2012-01-01

    UFOs ("Unidentified Falling Objects") are expected to be one of the major known performance limitation of the LHC. In this MD, the production mechanism and the dynamics of UFOs at the injection kicker magnets (MKIs) and the tune kicker magnets (MKQs) were studied. This was done by pulsing the MKIs and MKQs on a gap in the partly filled machine. During the MD, in total 58 UFO-type beam loss patterns were observed directly after pulsing the MKIs. None were observed after pulsing the MKQs, which provides important input for possible mitigation strategies. The temporal and spatial distribution of the UFO events could be determined by using a dedicated BLM Study Buffer, the implications for the UFO dynamics are discussed.

  16. The end-to-end testbed of the optical metrology system on-board LISA Pathfinder

    Energy Technology Data Exchange (ETDEWEB)

    Steier, F; Cervantes, F Guzman; Marin, A F GarcIa; Heinzel, G; Danzmann, K [Max-Planck-Institut fuer Gravitationsphysik (Albert-Einstein-Institut) and Universitaet Hannover (Germany); Gerardi, D, E-mail: frank.steier@aei.mpg.d [EADS Astrium Satellites GmbH, Friedrichshafen (Germany)

    2009-05-07

    LISA Pathfinder is a technology demonstration mission for the Laser Interferometer Space Antenna (LISA). The main experiment on-board LISA Pathfinder is the so-called LISA Technology Package (LTP) which has the aim to measure the differential acceleration between two free-falling test masses with an accuracy of 3 x 10{sup -14} ms{sup -2} Hz{sup -1/2} between 1 mHz and 30 mHz. This measurement is performed interferometrically by the optical metrology system (OMS) on-board LISA Pathfinder. In this paper, we present the development of an experimental end-to-end testbed of the entire OMS. It includes the interferometer and its sub-units, the interferometer backend which is a phasemeter and the processing of the phasemeter output data. Furthermore, three-axes piezo-actuated mirrors are used instead of the free-falling test masses for the characterization of the dynamic behaviour of the system and some parts of the drag-free and attitude control system (DFACS) which controls the test masses and the satellite. The end-to-end testbed includes all parts of the LTP that can reasonably be tested on earth without free-falling test masses. At its present status it consists mainly of breadboard components. Some of those have already been replaced by engineering models of the LTP experiment. In the next steps, further engineering and flight models will also be inserted in this testbed and tested against well-characterized breadboard components. The presented testbed is an important reference for the unit tests and can also be used for validation of the on-board experiment during the mission.

  17. Study of test-mass charging process in the LISA missions due to diffuse γ-rays

    International Nuclear Information System (INIS)

    Finetti, N; Scrimaglio, R; Grimani, C; Fabi, M

    2009-01-01

    Gravitational inertial sensors will be placed on board the Laser Interferometer Space Antenna (LISA) and aboard its precursor mission LISA Pathfinder (LISA-PF) in order to detect low frequency gravitational waves in space. Free-floating test-masses (Au 7 Pt 3 cubes) will be housed in inertial sensors for detecting possible laser signal variations induced by gravitational waves. Charging of the LISA test-masses due to exposure of the spacecraft to cosmic radiation and energetic solar particles will affect operation of gravitational inertial sensors. In this paper we report on the role of diffuse γ-rays in charging the LISA and LISA-PF test-masses with respect to protons and helium nuclei. The diffuse γ-ray flux in the Galaxy has been interpolated taking into account the outcomes of recent calculations. A comparison with γ-ray observations gathered by different experiments (COMPTEL and EGRET, Milagro, Whipple, HEGRA, TIBET) has been carried out. Simulations of the test-mass charging process have been performed by means of the FLUKA2006.3b package. Monte Carlo simulations of the interaction of cosmic particles with the LISA spacecraft indicate that the diffuse γ-ray contribution to the average steady-state test-mass charging rate and to the single-sided power spectrum of the charge rate noise is marginal with respect to that due to galactic cosmic-rays.

  18. mdFoam+: Advanced molecular dynamics in OpenFOAM

    Science.gov (United States)

    Longshaw, S. M.; Borg, M. K.; Ramisetti, S. B.; Zhang, J.; Lockerby, D. A.; Emerson, D. R.; Reese, J. M.

    2018-03-01

    This paper introduces mdFoam+, which is an MPI parallelised molecular dynamics (MD) solver implemented entirely within the OpenFOAM software framework. It is open-source and released under the same GNU General Public License (GPL) as OpenFOAM. The source code is released as a publicly open software repository that includes detailed documentation and tutorial cases. Since mdFoam+ is designed entirely within the OpenFOAM C++ object-oriented framework, it inherits a number of key features. The code is designed for extensibility and flexibility, so it is aimed first and foremost as an MD research tool, in which new models and test cases can be developed and tested rapidly. Implementing mdFoam+ in OpenFOAM also enables easier development of hybrid methods that couple MD with continuum-based solvers. Setting up MD cases follows the standard OpenFOAM format, as mdFoam+ also relies upon the OpenFOAM dictionary-based directory structure. This ensures that useful pre- and post-processing capabilities provided by OpenFOAM remain available even though the fully Lagrangian nature of an MD simulation is not typical of most OpenFOAM applications. Results show that mdFoam+ compares well to another well-known MD code (e.g. LAMMPS) in terms of benchmark problems, although it also has additional functionality that does not exist in other open-source MD codes.

  19. In-orbit performance of the LISA Pathfinder drag-free and attitude control system

    Science.gov (United States)

    Schleicher, A.; Ziegler, T.; Schubert, R.; Brandt, N.; Bergner, P.; Johann, U.; Fichter, W.; Grzymisch, J.

    2018-04-01

    LISA Pathfinder is a technology demonstrator mission that was funded by the European Space Agency and that was launched on December 3, 2015. LISA Pathfinder has been conducting experiments to demonstrate key technologies for the gravitational wave observatory LISA in its operational orbit at the L1 Lagrange point of the Earth-Sun system until final switch off on July 18, 2017. These key technologies include the inertial sensors, the optical metrology system, a set of µ-propulsion cold gas thrusters and in particular the high performance drag-free and attitude control system (DFACS) that controls the spacecraft in 15 degrees of freedom during its science phase. The main goal of the DFACS is to shield the two test masses inside the inertial sensors from all external disturbances to achieve a residual differential acceleration between the two test masses of less than 3 × 10-14 m/s2/√Hz over the frequency bandwidth of 1-30 mHz. This paper focuses on two important aspects of the DFACS that has been in use on LISA Pathfinder: the DFACS Accelerometer mode and the main DFACS Science mode. The Accelerometer mode is used to capture the test masses after release into free flight from the mechanical grabbing mechanism. The main DFACS Science Mode is used for the actual drag-free science operation. The DFACS control system has very strong interfaces with the LISA Technology Package payload which is a key aspect to master the design, development, and analysis of the DFACS. Linear as well as non-linear control methods are applied. The paper provides pre-flight predictions for the performance of both control modes and compares these predictions to the performance that is currently achieved in-orbit. Some results are also discussed for the mode transitions up to science mode, but the focus of the paper is on the Accelerometer mode performance and on the performance of the Science mode in steady state. Based on the achieved results, some lessons learnt are formulated to extend

  20. MD Test of a Ballistic Optics

    CERN Document Server

    Garcia-Tabares Valdivieso, Ana; Salvachua Ferrando, Belen Maria; Skowronski, Piotr Krzysztof; Solfaroli Camillocci, Matteo; Tomas Garcia, Rogelio; Wenninger, Jorg; Coello De Portugal - Martinez Vazquez, Jaime Maria; CERN. Geneva. ATS Department

    2016-01-01

    The ballistic optics is designed to improve the understanding of optical errors and BPM systematic effects in the critical triplet region. The particularity of that optics is that the triplet is switched off, effectively transforming the triplets on both sides of IR1 and IR5 into drift spaces. Advantage can be taken from that fact to localize better errors in the Q4-Q5-triplet region. During this MD this new optics was tested for the first time at injection with beam 2.

  1. Review: Lisa Mackenrodt, Swahili Spirit Possession and Islamic Healing in Contemporary Tanzania: The Jinn Fly on Friday (2011 Buchbesprechung: Lisa Mackenrodt, Swahili Spirit Possession and Islamic Healing in Contemporary Tanzania: The Jinn Fly on Friday (2011

    Directory of Open Access Journals (Sweden)

    Jigal Beez

    2013-01-01

    Full Text Available Review of the monograph:Lisa Mackenrodt, Swahili Spirit Possession and Islamic Healing in Contemporary Tanzania: The Jinn Fly on Friday, Hamburg: Verlag Dr. Kovač, 2011, ISBN 978-3-8300-5806-9, 216 pagesBesprechung der Monographie:Lisa Mackenrodt, Swahili Spirit Possession and Islamic Healing in Contemporary Tanzania: The Jinn Fly on Friday, Hamburg: Verlag Dr. Kovač, 2011, ISBN 978-3-8300-5806-9, 216 Seiten

  2. LISA Pathfinder E2E performance simulation: optical and self-gravity stability analysis

    Science.gov (United States)

    Brandt, N.; Fichter, W.; Kersten, M.; Lucarelli, S.; Montemurro, F.

    2005-05-01

    End-to-end (E2E) modelling and simulation, i.e. verifying the science performance of LISA Pathfinder (spacecraft and payload), is mandatory in order to minimize mission risks. In this paper, focus is on two particular applications of the E2E performance simulator currently being developed at EADS Astrium GmbH: the opto-dynamical stability and the self-gravity disturbance stability analysis. The E2E models applied here comprise the opto-dynamical modelling of the optical metrology systems (OMS) laser interferometry, the thermo-elastic distortion modelling of the OMS optical elements and the self-gravity disturbance model accounting for structural distortions. Preliminary analysis results are presented in detail, identifying shortcomings of the current LISA technology package (LTP) mounting baseline. As a consequence, the design is now being revised.

  3. LISA Pathfinder E2E performance simulation: optical and self-gravity stability analysis

    International Nuclear Information System (INIS)

    Brandt, N; Fichter, W; Kersten, M; Lucarelli, S; Montemurro, F

    2005-01-01

    End-to-end (E2E) modelling and simulation, i.e. verifying the science performance of LISA Pathfinder (spacecraft and payload), is mandatory in order to minimize mission risks. In this paper, focus is on two particular applications of the E2E performance simulator currently being developed at EADS Astrium GmbH: the opto-dynamical stability and the self-gravity disturbance stability analysis. The E2E models applied here comprise the opto-dynamical modelling of the optical metrology systems (OMS) laser interferometry, the thermo-elastic distortion modelling of the OMS optical elements and the self-gravity disturbance model accounting for structural distortions. Preliminary analysis results are presented in detail, identifying shortcomings of the current LISA technology package (LTP) mounting baseline. As a consequence, the design is now being revised

  4. Lifetime testing UV LEDs for use in the LISA charge management system

    Science.gov (United States)

    Hollington, D.; Baird, J. T.; Sumner, T. J.; Wass, P. J.

    2017-10-01

    As a future charge management light source, UV light-emitting diodes (UV LEDs) offer far superior performance in a range of metrics compared to the mercury lamps used in the past. As part of a qualification program a number of short wavelength UV LEDs have been subjected to a series of lifetime tests for potential use on the laser interferometer space antenna (LISA) mission. These tests were performed at realistic output levels for both fast and continuous discharging in either a DC or pulsed mode of operation and included a DC fast discharge test spanning 50 days, a temperature dependent pulsed fast discharge test spanning 21 days and a pulsed continuous discharge test spanning 507 days. Two types of UV LED have demonstrated lifetimes equivalent to over 25 years of realistic mission usage with one type providing a baseline for LISA and the other offering a backup solution.

  5. Lifetime testing UV LEDs for use in the LISA charge management system

    International Nuclear Information System (INIS)

    Hollington, D; Baird, J T; Sumner, T J; Wass, P J

    2017-01-01

    As a future charge management light source, UV light-emitting diodes (UV LEDs) offer far superior performance in a range of metrics compared to the mercury lamps used in the past. As part of a qualification program a number of short wavelength UV LEDs have been subjected to a series of lifetime tests for potential use on the laser interferometer space antenna (LISA) mission. These tests were performed at realistic output levels for both fast and continuous discharging in either a DC or pulsed mode of operation and included a DC fast discharge test spanning 50 days, a temperature dependent pulsed fast discharge test spanning 21 days and a pulsed continuous discharge test spanning 507 days. Two types of UV LED have demonstrated lifetimes equivalent to over 25 years of realistic mission usage with one type providing a baseline for LISA and the other offering a backup solution. (paper)

  6. LISA: A performance assessment code for geological repositories of radioactive waste

    International Nuclear Information System (INIS)

    Bertozzi, G.; Saltelli, A.

    1985-01-01

    LISA, developed at JRC-Ispra, is a statistical code, which calculates the radiation exposures and risks associated with radionuclide releases from geological repositories of nuclear waste. The assessment methodology is described briefly. It requires that a number of probabilistic components be quantified and introduced in the analysis; the results are thus expressed in terms of risk. The subjective judgment of experts may be necessary to quantify the probabilities of occurrence of rare geological events. Because of large uncertainties in input data, statistical treatment of the Monte Carlo type is utilized for the analysis; thus, the output from LISA is obtained in the form of distributions. A few results of an application to a probabilistic scenario for a repository mined in a clay bed are illustrated

  7. Construction of an optical test-bed for eLISA

    International Nuclear Information System (INIS)

    Lieser, Maike; Isleif, K-S; Schuster, S; Tröbs, M; Veith, S; Heinzel, G; Danzmann, K; Fitzsimons, E; Killow, C; Perreur-Lloyd, M; Robertson, D; Ward, H

    2016-01-01

    In the planned eLISA mission a key part of the system is the optical bench that holds the interferometers for reading out the inter-spacecraft distance and the test mass position. We report on ongoing technology development for the eLISA optical system like the back-link between the optical benches and the science interferometer where the local beam is interfered with the received beam from the distant spacecraft. The focus will be on a setup to investigate the tilt-to-pathlength coupling in the science interferometer. To test the science interferometer in the lab a second bench providing a laser beam and a reference interferometer is needed. We present a setup with two ultra-stable low expansion glass benches and bonded optics. To suppress the tilt-to-pathlength coupling to the required level (few μm/rad) imaging optics are placed in front of the interferometer photo diodes. (paper)

  8. The Mock LISA Data Challenges: from Challenge 1B to Challenge 3

    International Nuclear Information System (INIS)

    Babak, Stanislav; Porter, Edward K; Gair, Jonathan; Baker, John G; Arnaud, Keith; Benacquista, Matthew J; Cornish, Neil J; Crowder, Jeff; Vallisneri, Michele; Cutler, Curt; Larson, Shane L; Plagnol, Eric; Vecchio, Alberto; Barack, Leor; Blaut, Arkadiusz; Fairhurst, Stephen; Harry, Ian; Gong Xuefei; Khurana, Deepak; Krolak, Andrzej

    2008-01-01

    The Mock LISA Data Challenges are a programme to demonstrate and encourage the development of LISA data-analysis capabilities, tools and techniques. At the time of this workshop, three rounds of challenges had been completed, and the next was about to start. In this paper we provide a critical analysis of the entries to the latest completed round, Challenge 1B. The entries confirm the consolidation of a range of data-analysis techniques for galactic and massive-black-hole binaries, and they include the first convincing examples of detection and parameter estimation of extreme-mass-ratio inspiral sources. In this paper we also introduce the next round, Challenge 3. Its data sets feature more realistic waveform models (e.g., galactic binaries may now chirp, and massive-black-hole binaries may precess due to spin interactions), as well as new source classes (bursts from cosmic strings, isotropic stochastic backgrounds) and more complicated nonsymmetric instrument noise

  9. arXiv Probing non-Gaussian Stochastic Gravitational Wave Backgrounds with LISA

    CERN Document Server

    Bartolo, Nicola; Figueroa, Daniel G.; Garcia-Bellido, Juan; Peloso, Marco; Pieroni, Mauro; Ricciardone, Angelo; Sakellariadou, Mairi; Sorbo, Lorenzo; Tasinato, Gianmassimo

    The stochastic gravitational wave background (SGWB) contains a wealth of information on astrophysical and cosmological processes. A major challenge of upcoming years will be to extract the information contained in this background and to disentangle the contributions of different sources. In this paper we provide the formalism to extract, from the correlation of three signals in the Laser Interferometer Space Antenna (LISA), information about the tensor three-point function, which characterizes the non-Gaussian properties of the SGWB. Compared to the two-point function, the SGWB three-point function has a richer dependence on the gravitational wave momenta and chiralities, and a larger number of signal channels. It can be used therefore as a powerful discriminator between different models. We provide LISA's response functions to a general SGWB three-point function. As examples, we study in full detail the cases of an equilateral and squeezed SGWB bispectra, and provide the explicit form of the response functio...

  10. LTP - LISA technology package: Development challenges of a spaceborne fundamental physics experiment

    Energy Technology Data Exchange (ETDEWEB)

    Gerndt, R, E-mail: ruediger.gerndt@astrium.eads.ne [Astrium Satellites GmbH, Claude-Dornier-Str., 88090 Immenstaad (Germany)

    2009-03-01

    The LISA Technology Package (LTP) is the main payload onboard the LISA Pathfinder Spacecraft. The LTP Instrument together with the Drag-Free Attitude Control System (DFACS) and the respective LTP and DFACS operational software forms the LTP Experiment. It is completed by the FEEPs of the LPF spacecraft that are controlled by DFACS in order to control the spacecraft's attitude along with the experiment's needs. This article concentrates on aspects of the Industrial development of the LTP Instrument items and on essential performance issues of LTP. Examples of investigations on specific issue will highlight the kind of special problems to be solved for LTP in close cooperation with the Scientific Community.

  11. Detection of Double White Dwarf Binaries with Gaia, LSST and eLISA

    Science.gov (United States)

    Korol, V.; Rossi, E. M.; Groot, P. J.

    2017-03-01

    According to simulations around 108 double degenerate white dwarf binaries are expected to be present in the Milky Way. Due to their intrinsic faintness, the detection of these systems is a challenge, and the total number of detected sources so far amounts only to a few tens. This will change in the next two decades with the advent of Gaia, the LSST and eLISA. We present an estimation of how many compact DWDs with orbital periods less than a few hours we will be able to detect 1) through electromagnetic radiation with Gaia and LSST and 2) through gravitational wave radiation with eLISA. We find that the sample of simultaneous electromagnetic and gravitational waves detections is expected to be substantial, and will provide us a powerful tool for probing the white dwarf astrophysics and the structure of the Milky Way, letting us into the era of multi-messenger astronomy for these sources.

  12. Possible Periodic Orbit Control Maneuvers for an eLISA Mission

    Science.gov (United States)

    Bender, Peter L.; Welter, Gary L.

    2012-01-01

    This paper investigates the possible application of periodic orbit control maneuvers for so-called evolved-LISA (eLISA) missions, i.e., missions for which the constellation arm lengths and mean distance from the Earth are substantially reduced. We find that for missions with arm lengths of 106 km and Earth-trailing distance ranging from approx. 12deg to 20deg over the science lifetime, the occasional use of the spacecraft micro-Newton thrusters for constellation configuration maintenance should be able to essentially eliminate constellation distortion caused by Earth-induced tidal forces at a cost to science time of only a few percent. With interior angle variation kept to approx. +/-0:1deg, the required changes in the angles between the laser beam pointing directions for the two arms from any spacecraft could be kept quite small. This would considerably simplify the apparatus necessary for changing the transmitted beam directions.

  13. Searching for massive black hole binaries in the first Mock LISA Data Challenge

    International Nuclear Information System (INIS)

    Cornish, Neil J; Porter, Edward K

    2007-01-01

    The Mock LISA Data Challenge is a worldwide effort to solve the LISA data analysis problem. We present here our results for the massive black hole binary (BBH) section of round 1. Our results cover challenge 1.2.1, where the coalescence of the binary is seen, and challenge 1.2.2, where the coalescence occurs after the simulated observational period. The data stream is composed of Gaussian instrumental noise plus an unknown BBH waveform. Our search algorithm is based on a variant of the Markov chain Monte Carlo method that uses Metropolis-Hastings sampling and thermostated frequency annealing. We present results from the training data sets where we know the parameter values a priori and the blind data sets where we were informed of the parameter values after the challenge had finished. We demonstrate that our algorithm is able to rapidly locate the sources, accurately recover the source parameters and provide error estimates for the recovered parameters

  14. Supermassive Black Holes as Revealed by LISA: How Gravitational Wave Astronomy Will be a Game Changer

    Science.gov (United States)

    Holley-Bockelmann, Kelly

    2018-04-01

    Astronomers now know that supermassive black holes are in nearly every galaxy.Though these black holes are an observational certainty, nearly every aspect of their evolution -- from their birth, to their fuel source, to their basic dynamics -- is a matter of lively debate. Fortunately, LISA, a space-based gravitational wave observatory set to launch in 2034, will revolutionize this field by providing data that is complementary to electromagnetic observations as well as data in regimes that are electromagnetically dark. This talk will touch on our current understanding of how SMBHs form, evolve, and alter their galaxy host, and will outline the theoretical, computational and observational work needed to make the most of LISA observations.

  15. ProtoMD: A prototyping toolkit for multiscale molecular dynamics

    Science.gov (United States)

    Somogyi, Endre; Mansour, Andrew Abi; Ortoleva, Peter J.

    2016-05-01

    ProtoMD is a toolkit that facilitates the development of algorithms for multiscale molecular dynamics (MD) simulations. It is designed for multiscale methods which capture the dynamic transfer of information across multiple spatial scales, such as the atomic to the mesoscopic scale, via coevolving microscopic and coarse-grained (CG) variables. ProtoMD can be also be used to calibrate parameters needed in traditional CG-MD methods. The toolkit integrates 'GROMACS wrapper' to initiate MD simulations, and 'MDAnalysis' to analyze and manipulate trajectory files. It facilitates experimentation with a spectrum of coarse-grained variables, prototyping rare events (such as chemical reactions), or simulating nanocharacterization experiments such as terahertz spectroscopy, AFM, nanopore, and time-of-flight mass spectroscopy. ProtoMD is written in python and is freely available under the GNU General Public License from github.com/CTCNano/proto_md.

  16. Lisa B Signorello, ScD, ScM | Division of Cancer Prevention

    Science.gov (United States)

    Lisa Signorello is the Director and Chief of the Cancer Prevention Fellowship Program (CPFP) Branch in the National Cancer Institute's Division of Cancer Prevention. Dr. Signorello served as Deputy Director of the CPFP from August 2014 to November 2017 and came to the NCI after having held academic positions at the Harvard School of Public Health, Harvard Medical School, and Vanderbilt University, as well as having had significant private sector research experience. |

  17. Laser frequency stabilization and stray light issues for LISA and other future multi-spacecraft missions Project

    Data.gov (United States)

    National Aeronautics and Space Administration — "The Laser Interferometer Space Antenna (LISA) is a joint NASA/ESA project which will use laser interferometry between drag-free proof masses to measure...

  18. Demonstration of AC and DC charge control for the LISA test masses

    Science.gov (United States)

    Olatunde, Taiwo Janet

    2018-01-01

    Taiwo Olatunde, Stephen Apple, Andrew Chilton, Samantha Parry, Peter Wass, Guido Mueller, John W. Conklin The residual test mass acceleration in LISA must be below 3 fm/s2/√Hz at all frequencies between 0.1 and 3 mHz. Test mass charge coupled with stray electrical potentials and external electromagnetic fields is a well-known source of acceleration noise. LISA Pathfinder uses Hg lamps emitting mostly around 254 nm to discharge the test masses via photoemission, but a future LISA mission launched around 2030 will likely replace the lamps with newer UV LEDs with lower mass, better power efficiency, smaller size and higher bandwidth. This presentation will discuss charge control demonstrated on the torsion pendulum in AC and DC modes at the University of Florida using latest generation UV LEDs producing light at 240 nm with energy above the work function of pure Au. Initial results of Au quantum efficiency measurements (number of emitted electrons per incident photons) which is critical for bi-polar charge control will also be presented.

  19. Renormalized second post-Newtonian spin contributions to the accumulated orbital phase for LISA sources

    International Nuclear Information System (INIS)

    Gergely, Laszlo Arpad; Mikoczi, Balazs

    2009-01-01

    We give here a new third post-Newtonian (3PN) spin-spin contribution (in the PN parameter ε) to the accumulated orbital phase of a compact binary, arising from the spin-orbit precessional motion of the spins. In the equal mass case, this contribution vanishes, but Laser Interferometer Space Antenna (LISA) sources of merging supermassive binary black holes have typically a mass ratio of 1:10. For such nonequal masses, this 3PN correction is periodic in time, with a period approximately ε -1 times larger than the period of gravitational waves. We derive a renormalized and simpler expression of the spin-spin coefficient at 2PN, as an average over the time scale of this period of the combined 2PN and 3PN contribution. We also find that for LISA sources the quadrupole-monopole contribution to the phase dominates over the spin-spin contribution, while the self-spin contribution is negligible even for the dominant spin. Finally, we define a renormalized total spin coefficient σ to be employed in the search for gravitational waves emitted by LISA sources.

  20. Low-Frequency Gravitational-Wave Science with eLISA/ NGO

    Science.gov (United States)

    Amaro-Seoane, Pau; Aoudia, Sofiane; Babak, Stanislav; Binetruy, Pierre; Berti, Emanuele; Bohe, Alejandro; Caprini, Chiara; Colpi, Monica; Cornish, Neil J.; Danzmann, Karsten; hide

    2011-01-01

    We review the expected science performance of the New Gravitational-Wave Observatory (NGO, a.k.a. eLISA), a mission under study by the European Space Agency for launch in the early 2020s. eLISA will survey the low-frequency gravitational-wave sky (from 0.1 mHz to 1 Hz), detecting and characterizing a broad variety of systems and events throughout the Universe, including the coalescences of massive black holes brought together by galaxy mergers; the inspirals of stellar-mass black holes and compact stars into central galactic black holes; several millions of ultracompact binaries, both detached and mass transferring, in the Galaxy; and possibly unforeseen sources such as the relic gravitational-wave radiation from the early Universe. eLISA's high signal-to-noise measurements will provide new insight into the structure and history of the Universe, and they will test general relativity in its strong-field dynamical regime.

  1. Sub-pm{{\\sqrt{Hz}^{-1}}} non-reciprocal noise in the LISA backlink fiber

    Science.gov (United States)

    Fleddermann, Roland; Diekmann, Christian; Steier, Frank; Tröbs, Michael; Heinzel, Gerhard; Danzmann, Karsten

    2018-04-01

    The future space-based gravitational wave detector laser interferometer space antenna (LISA) requires bidirectional exchange of light between its two optical benches on board of each of its three satellites. The current baseline foresees a polarization-maintaining single-mode fiber for this backlink connection. Phase changes which are common in both directions do not enter the science measurement, but differential (‘non-reciprocal’) phase fluctuations directly do and must thus be guaranteed to be small enough. We have built a setup consisting of a Zerodur baseplate with fused silica components attached to it using hydroxide-catalysis bonding and demonstrated the reciprocity of a polarization-maintaining single-mode fiber at the 1 pm \\sqrt{Hz}-1 level as is required for LISA. We used balanced detection to reduce the influence of parasitic optical beams on the reciprocity measurement and a fiber length stabilization to avoid nonlinear effects in our phase measurement system (phase meter). For LISA, a different phase meter is planned to be used that does not show this nonlinearity. We corrected the influence of beam angle changes and temperature changes on the reciprocity measurement in post-processing.

  2. Combining Rosetta with molecular dynamics (MD): A benchmark of the MD-based ensemble protein design.

    Science.gov (United States)

    Ludwiczak, Jan; Jarmula, Adam; Dunin-Horkawicz, Stanislaw

    2018-07-01

    Computational protein design is a set of procedures for computing amino acid sequences that will fold into a specified structure. Rosetta Design, a commonly used software for protein design, allows for the effective identification of sequences compatible with a given backbone structure, while molecular dynamics (MD) simulations can thoroughly sample near-native conformations. We benchmarked a procedure in which Rosetta design is started on MD-derived structural ensembles and showed that such a combined approach generates 20-30% more diverse sequences than currently available methods with only a slight increase in computation time. Importantly, the increase in diversity is achieved without a loss in the quality of the designed sequences assessed by their resemblance to natural sequences. We demonstrate that the MD-based procedure is also applicable to de novo design tasks started from backbone structures without any sequence information. In addition, we implemented a protocol that can be used to assess the stability of designed models and to select the best candidates for experimental validation. In sum our results demonstrate that the MD ensemble-based flexible backbone design can be a viable method for protein design, especially for tasks that require a large pool of diverse sequences. Copyright © 2018 Elsevier Inc. All rights reserved.

  3. MD-11 PCA - First Landing at Edwards

    Science.gov (United States)

    1995-01-01

    This McDonnell Douglas MD-11 approaches the first landing ever of a transport aircraft under engine power only on Aug. 29, 1995, at NASA's Dryden Flight Research Center, Edwards, California. The milestone flight, flown by NASA research pilot and former astronaut Gordon Fullerton, was part of a NASA project to develop a computer-assisted engine control system that enables a pilot to land a plane safely when it normal control surfaces are disabled. The Propulsion-Controlled Aircraft (PCA) system uses standard autopilot controls already present in the cockpit, together with the new programming in the aircraft's flight control computers. The PCA concept is simple--for pitch control, the program increases thrust to climb and reduces thrust to descend. To turn right, the autopilot increases the left engine thrust while decreasing the right engine thrust. The initial Propulsion-Controlled Aircraft studies by NASA were carried out at Dryden with a modified twin-engine F-15 research aircraft.

  4. MD-11 PCA - Research flight team egress

    Science.gov (United States)

    1995-01-01

    This McDonnell Douglas MD-11 has parked on the flightline at NASA's Dryden Flight Research Center, Edwards, California, following its completion of the first and second landings ever performed by a transport aircraft under engine power only (on Aug. 29, 1995). The milestone flight, with NASA research pilot and former astronaut Gordon Fullerton at the controls, was part of a NASA project to develop a computer-assisted engine control system that enables a pilot to land a plane safely when its normal control surfaces are disabled. Coming down the steps from the aircraft are Gordon Fullerton (in front), followed by Bill Burcham, Propulsion Controlled Aircraft (PCA) project engineer at Dryden; NASA Dryden controls engineer John Burken; John Feather of McDonnell Douglas; and Drew Pappas, McDonnell Douglas' project manager for PCA.

  5. Automatic system for quantification and visualization of lung aeration on chest computed tomography images: the Lung Image System Analysis - LISA

    Energy Technology Data Exchange (ETDEWEB)

    Felix, John Hebert da Silva; Cortez, Paulo Cesar, E-mail: jhsfelix@gmail.co [Universidade Federal do Ceara (UFC), Fortaleza, CE (Brazil). Dept. de Engenharia de Teleinformatica; Holanda, Marcelo Alcantara [Universidade Federal do Ceara (UFC), Fortaleza, CE (Brazil). Hospital Universitario Walter Cantidio. Dept. de Medicina Clinica

    2010-12-15

    High Resolution Computed Tomography (HRCT) is the exam of choice for the diagnostic evaluation of lung parenchyma diseases. There is an increasing interest for computational systems able to automatically analyze the radiological densities of the lungs in CT images. The main objective of this study is to present a system for the automatic quantification and visualization of the lung aeration in HRCT images of different degrees of aeration, called Lung Image System Analysis (LISA). The secondary objective is to compare LISA to the Osiris system and also to specific algorithm lung segmentation (ALS), on the accuracy of the lungs segmentation. The LISA system automatically extracts the following image attributes: lungs perimeter, cross sectional area, volume, the radiological densities histograms, the mean lung density (MLD) in Hounsfield units (HU), the relative area of the lungs with voxels with density values lower than -950 HU (RA950) and the 15th percentile of the least density voxels (PERC15). Furthermore, LISA has a colored mask algorithm that applies pseudo-colors to the lung parenchyma according to the pre-defined radiological density chosen by the system user. The lungs segmentations of 102 images of 8 healthy volunteers and 141 images of 11 patients with Chronic Obstructive Pulmonary Disease (COPD) were compared on the accuracy and concordance among the three methods. The LISA was more effective on lungs segmentation than the other two methods. LISA's color mask tool improves the spatial visualization of the degrees of lung aeration and the various attributes of the image that can be extracted may help physicians and researchers to better assess lung aeration both quantitatively and qualitatively. LISA may have important clinical and research applications on the assessment of global and regional lung aeration and therefore deserves further developments and validation studies. (author)

  6. Automatic system for quantification and visualization of lung aeration on chest computed tomography images: the Lung Image System Analysis - LISA

    International Nuclear Information System (INIS)

    Felix, John Hebert da Silva; Cortez, Paulo Cesar; Holanda, Marcelo Alcantara

    2010-01-01

    High Resolution Computed Tomography (HRCT) is the exam of choice for the diagnostic evaluation of lung parenchyma diseases. There is an increasing interest for computational systems able to automatically analyze the radiological densities of the lungs in CT images. The main objective of this study is to present a system for the automatic quantification and visualization of the lung aeration in HRCT images of different degrees of aeration, called Lung Image System Analysis (LISA). The secondary objective is to compare LISA to the Osiris system and also to specific algorithm lung segmentation (ALS), on the accuracy of the lungs segmentation. The LISA system automatically extracts the following image attributes: lungs perimeter, cross sectional area, volume, the radiological densities histograms, the mean lung density (MLD) in Hounsfield units (HU), the relative area of the lungs with voxels with density values lower than -950 HU (RA950) and the 15th percentile of the least density voxels (PERC15). Furthermore, LISA has a colored mask algorithm that applies pseudo-colors to the lung parenchyma according to the pre-defined radiological density chosen by the system user. The lungs segmentations of 102 images of 8 healthy volunteers and 141 images of 11 patients with Chronic Obstructive Pulmonary Disease (COPD) were compared on the accuracy and concordance among the three methods. The LISA was more effective on lungs segmentation than the other two methods. LISA's color mask tool improves the spatial visualization of the degrees of lung aeration and the various attributes of the image that can be extracted may help physicians and researchers to better assess lung aeration both quantitatively and qualitatively. LISA may have important clinical and research applications on the assessment of global and regional lung aeration and therefore deserves further developments and validation studies. (author)

  7. Non-linear quantization error reduction for the temperature measurement subsystem on-board LISA Pathfinder

    Science.gov (United States)

    Sanjuan, J.; Nofrarias, M.

    2018-04-01

    Laser Interferometer Space Antenna (LISA) Pathfinder is a mission to test the technology enabling gravitational wave detection in space and to demonstrate that sub-femto-g free fall levels are possible. To do so, the distance between two free falling test masses is measured to unprecedented sensitivity by means of laser interferometry. Temperature fluctuations are one of the noise sources limiting the free fall accuracy and the interferometer performance and need to be known at the ˜10 μK Hz-1/2 level in the sub-millihertz frequency range in order to validate the noise models for the future space-based gravitational wave detector LISA. The temperature measurement subsystem on LISA Pathfinder is in charge of monitoring the thermal environment at key locations with noise levels of 7.5 μK Hz-1/2 at the sub-millihertz. However, its performance worsens by one to two orders of magnitude when slowly changing temperatures are measured due to errors introduced by analog-to-digital converter non-linearities. In this paper, we present a method to reduce this effect by data post-processing. The method is applied to experimental data available from on-ground validation tests to demonstrate its performance and the potential benefit for in-flight data. The analog-to-digital converter effects are reduced by a factor between three and six in the frequencies where the errors play an important role. An average 2.7 fold noise reduction is demonstrated in the 0.3 mHz-2 mHz band.

  8. Modulator noise suppression in the LISA time-delay interferometric combinations

    International Nuclear Information System (INIS)

    Tinto, Massimo; Armstrong, J W; Estabrook, Frank B

    2008-01-01

    Laser Interferometer Space Antenna (LISA) is a mission to detect and study low-frequency cosmic gravitational radiation through its influence on the phases of six modulated laser beams exchanged between three remote spacecraft. We previously showed how the measurements of some 18 time series of relative frequency or phase shifts could be combined (1) to cancel the phase noise of the lasers, (2) to cancel the Doppler fluctuations due to non-inertial motions of the six optical benches and (3) to remove the phase noise of the onboard reference oscillators required to track the photodetector fringes, all the while preserving signals from passing gravitational waves. Here we analyze the effect of the additional noise due to the optical modulators used for removing the phase fluctuations of the onboard reference oscillators. We use the recently measured noise spectrum of an individual modulator (Klipstein et al 2006 Proc. 6th Int. LISA Symp. (Greenbelt, MA) (AIP Conf. Proc. vol 873) ed S M Merkowitz and J C Livas pp 19-23) to quantify the contribution of modulator noise to the first and second-generation time-delay interferometric (TDI) combinations as a function of the modulation frequency. We show that modulator noise can be made smaller than the expected proof-mass acceleration and optical-path noises if the modulation frequencies are larger than ∼682 MHz in the case of the unequal-arm Michelson TDI combination X 1 , ∼ 1.08 GHz for the Sagnac TDI combination α 1 , and ∼706 MHz for the symmetrical Sagnac TDI combination ζ 1 . These modulation frequencies are substantially smaller than previously estimated and may lead to less stringent requirements on the LISA's oscillator noise calibration subsystem. The measurements in Klipstein et al were performed in a laboratory experiment for a range of modulation frequencies, but we emphasize that, for the reference oscillator noise calibration algorithm to work, the modulation frequencies must be equal to the

  9. Massive Black Hole Mergers: Can We "See" what LISA will "Hear"?

    Science.gov (United States)

    Centrella, Joan

    2010-01-01

    The final merger of massive black holes produces strong gravitational radiation that can be detected by the space-borne LISA. If the black hole merger takes place in the presence of gas and magnetic fields, various types of electromagnetic signals may also be produced. Modeling such electromagnetic counterparts of the final merger requires evolving the behavior of both gas and fields in the strong-field regions around the black holes. We will review current efforts to simulate these systems, and discuss possibilities for observing the electromagnetic signals they produce.

  10. LISA - a powerful program package for LIstmode and Spectral data Analysis

    International Nuclear Information System (INIS)

    Oberstedt, A.; Hambsch, F.J.

    1994-01-01

    LISA is a graphical program package which enables both off-line listmode and spectral data evaluation as well as on-line monitoring while multi-parameter experiments are running. It can be executed on every computer with a UNIX operating system and an X-WINDOW environment, running PV-WAVE from Visual Numerics Incorporation. This package is basically written in the language PV-WAVE CL, but integration of procedures written in the C-language and execution of UNIX shell commands lead to an additional increase of performance. (orig.)

  11. On-orbit alignment and diagnostics for the LISA Technology Package

    International Nuclear Information System (INIS)

    MarIn, A F GarcIa; Wand, V; Steier, F; Cervantes, F Guzman; Bogenstahl, J; Jennrich, O; Heinzel, G; Danzmann, K

    2006-01-01

    This paper presents a procedure to perform fully autonomous on-orbit alignment of the interferometer on board the LISA Technology Package (LTP). LTP comprises two free-floating test masses as inertial sensors that additionally serve as end mirrors of a set of interferometers. From the output signals of the interferometers, a subset has been selected to obtain alignment information of the test masses. Based on these signals, an alignment procedure was developed and successfully tested on the engineering model of the optical bench. Furthermore, operation procedures for the characterization of critical on-orbit properties of the optical metrology system (e.g. fibre noise) have been established

  12. After-dinner speech: the path of LISA to become ‘L3’

    Science.gov (United States)

    Huber, M. C. E.

    2017-05-01

    We describe the state of fundamental-physics experiments in space in the mid 1980s on both sides of the Atlantic, and then follow the development of this field within ESA’s Scientific Programme. The special case of LISA — a fundamental physics experiment in space also supported by astronomers, and now, following the ground-based detection of gravitational waves, the means to extend the observable spectrum of such waves towards lower frequencies and long-lasting signals — is then followed in its rise to become the ‘Large Project L3’ of ESA.

  13. Observing extreme-mass-ratio inspirals with eLISA/NGO

    OpenAIRE

    Gair, Jonathan R; Porter, Edward K

    2012-01-01

    The extreme-mass-ratio inspirals (EMRIs) of stellar mass compact objects into massive black holes in the centres of galaxies are an important source of low-frequency gravitational waves for space-based detectors. We discuss the prospects for detecting these sources with the evolved Laser Interferometer Space Antenna (eLISA), recently proposed as an ESA mission candidate under the name NGO. We show that NGO could observe a few tens of EMRIs over its two year mission lifetime at redshifts z < 0...

  14. LISA. A code for safety assessment in nuclear waste disposals program description and user guide

    International Nuclear Information System (INIS)

    Saltelli, A.; Bertozzi, G.; Stanners, D.A.

    1984-01-01

    The code LISA (Long term Isolation Safety Assessment), developed at the Joint Research Centre, Ispra is a useful tool in the analysis of the hazard due to the disposal of nuclear waste in geological formations. The risk linked to preestablished release scenarios is assessed by the code in terms of dose rate to a maximum exposed individual. The various submodels in the code simulate the system of barriers -both natural and man made- which are interposed between the contaminants and man. After a description of the code features a guide for the user is supplied and then a test case is presented

  15. Effects of different eLISA-like configurations on massive black hole parameter estimation

    Science.gov (United States)

    Porter, Edward K.

    2015-09-01

    As the theme for the future L3 Cosmic Vision mission, ESA has recently chosen the "Gravitational Wave Universe." Within this program, a mission concept called eLISA has been proposed. This observatory has a current initial configuration consisting of four laser links between the three satellites, which are separated by a distance of one million kilometers, constructing a single-channel Michelson interferometer. However, the final configuration for the observatory will not be fixed until the end of this decade. With this in mind, we investigate the effect of different eLISA-like configurations on massive black hole detections. This work compares the results of a Bayesian inference study of 120 massive black hole binaries out to a redshift of z ˜13 for a 106 km arm length eLISA with four and six links, as well as a 2 ×106 km arm length observatory with four links. We demonstrate that the original eLISA configuration should allow us to recover the luminosity distance of the source with an error of less than 10% out to a redshift of z ˜4 , and a sky error box of Δ Ω ≤102 deg2 out to z ˜0.1 . In contrast, both alternative configurations suggest that we should be able to conduct the same parameter recovery with errors of less than 10% in luminosity distance out to z ˜12 and Δ Ω ≤102 deg2 out to z ˜0.4 . Using the information from these studies, we also infer that if we were able to construct a 2 Gm, six-link detector, the above values would shift to z ˜20 for luminosity distance and z ˜0.9 for sky error. While the final configuration will also be dependent on both technological and financial considerations, our study suggests that increasing the size of a two-arm detector is a viable alternative to the inclusion of a third arm in a smaller detector. More importantly, this work further suggests no clear scientific loss between either choice.

  16. MD simulation of cluster formation during sputtering

    International Nuclear Information System (INIS)

    Muramoto, T.; Okai, M.; Yamashita, Y.; Yorizane, K.; Yamamura, Y.

    2001-01-01

    The cluster ejection due to cluster impact on a solid surface is studied through molecular dynamics (MD) simulations. Simulations are performed for Cu cluster impacts on the Cu(1 1 1) surface for cluster energy 100 eV/atom, and for clusters of 6, 13, 28 and 55 atoms. Interatomic interactions are described by the AMLJ-EAM potential. The vibration energy spectrum is independent of the incident cluster size and energy. This comes from the fact that sputtered clusters become stable through the successive fragmentation of nascent large sputtered clusters. The vibration energy spectra for large sputtered clusters have a peak, whose energy corresponds to the melting temperature of Cu. The exponent of the power-law fit of the abundance distribution and the total sputtering yield for the cluster impacts are higher than that for the monatomic ion impacts with the same total energy, where the exponent δ is given by Y n ∝n δ and Y n is the yield of sputtered n-atom cluster. The exponent δ follows a unified function of the total sputtering yield, which is a monotonic increase function, and it is nearly equal to δ ∼ -3 for larger yield

  17. Orbit Feedback Operation with RCBX (MD 1209)

    CERN Document Server

    Wenninger, Jorg; Nisbet, David; Ponce, Laurette; Louro Alves, Diogo Miguel; CERN. Geneva. ATS Department

    2017-01-01

    The LHC Orbit Feedback (OFB) is able to drive any orbit corrector circuit (COD) to steer the LHC orbit. But during the first feedback tests in 2010, all attempts to use the common triplet orbit correctors (MCBX) failed because the QPS system installed to protect those magnets triggered power aborts as soon as the OFB steered the beam with those CODs. The reason was most likely the violation of the RCBX circuit acceleration limits. For this reason the MCBX orbit correctors were never driven by the OFB in regular operation. Although the performance of the OFB is generally excellent, the quality of the beam steering around IRs could be improved if the OFB could correct the orbit with the MCBX to counteract locally triplet quadrupole movements. The aim of this MD was to make a new attempt to use the MCBX in the OFB. The test was successful at injection (no circuit trip) and failed during the ramp (QPS power abort). The PC voltages and QPS Ures signals revealed the presence of voltage spikes with a period of 10~s...

  18. Constraining early and interacting dark energy with gravitational wave standard sirens: the potential of the eLISA mission

    International Nuclear Information System (INIS)

    Caprini, Chiara; Tamanini, Nicola

    2016-01-01

    We perform a forecast analysis of the capability of the eLISA space-based interferometer to constrain models of early and interacting dark energy using gravitational wave standard sirens. We employ simulated catalogues of standard sirens given by merging massive black hole binaries visible by eLISA, with an electromagnetic counterpart detectable by future telescopes. We consider three-arms mission designs with arm length of 1, 2 and 5 million km, 5 years of mission duration and the best-level low frequency noise as recently tested by the LISA Pathfinder. Standard sirens with eLISA give access to an intermediate range of redshift 1 ∼< z ∼< 8, and can therefore provide competitive constraints on models where the onset of the deviation from ΛCDM (i.e. the epoch when early dark energy starts to be non-negligible, or when the interaction with dark matter begins) occurs relatively late, at z ∼< 6. If instead early or interacting dark energy is relevant already in the pre-recombination era, current cosmological probes (especially the cosmic microwave background) are more efficient than eLISA in constraining these models, except possibly in the interacting dark energy model if the energy exchange is proportional to the energy density of dark energy.

  19. 77 FR 5201 - Drawbridge Operation Regulation; Bear Creek, Dundalk, MD

    Science.gov (United States)

    2012-02-02

    ...-AA09 Drawbridge Operation Regulation; Bear Creek, Dundalk, MD AGENCY: Coast Guard, DHS. ACTION: Notice... operation of the Baltimore County highway bridge at Wise Avenue across Bear Creek, mile 3.4, between Dundalk... Avenue across Bear Creek, mile 3.4 between Dundalk and Sparrows Point, MD. This change would require the...

  20. MD290: Q4 IP6 Quench Level

    CERN Document Server

    Bednarek, Mateusz Jakub; Lechner, Anton; CERN. Geneva. ATS Department

    2016-01-01

    The detailed program proposed for the LHC Machine Development concerning a quench induced by fast losses on the MQY.4L6 quadrupole is presented. The merit of the MD, the necessary modifications of the machine protection systems are presented together with a preliminary analysis of the MD results.

  1. Chosen-Prefix Collisions for MD5 and Applications

    NARCIS (Netherlands)

    M.M.J. Stevens (Marc); A.K. Lenstra (Arjen); B. de Weger (Benne)

    2012-01-01

    textabstractWe present a novel, automated way to find differential paths for MD5. Its main application is in the construction of \\emph{chosen-prefix collisions}. We have shown how, at an approximate expected cost of $2^{39}$ calls to the MD5 compression function, for any two chosen

  2. Waiting time distribution in M/D/1 queueing systems

    DEFF Research Database (Denmark)

    Iversen, Villy Bæk; Staalhagen, Lars

    1999-01-01

    The well-known formula for the waiting time distribution of M/D/1 queueing systems is numerically unsuitable when the load is close to 1.0 and/or the results for a large waiting time are required. An algorithm for any load and waiting time is presented, based on the state probabilities of M/D/1...

  3. Temperature dependence of gafchromic MD-55 dosimeter

    International Nuclear Information System (INIS)

    Klassen, Norman V.; Zwan, Len van der; Cygler, Joanna

    1997-01-01

    Objective: Gafchromic MD-55 is a fairly new, thin film dosimeter that develops a blue color (λ max = 676 nm) when irradiated with ionizing radiation. The increase in absorbance is nearly proportional to the absorbed dose. MD-55 can be used for high precision dosimetry if care is taken to assure reproducible film orientation in the spectrophotometer as well as temperature control during both irradiation and reading. In order to achieve the maximum sensitivity of this dosimeter the readings of the optical density should be taken at λ max . It was reported for another type of Gafchromic film (DM-1260), that both λ max and ε max decrease with an increase in the temperature of the spectrophotometer. The purpose of this study was to characterize the reading temperature dependence of the new type of Gafchromic film available on the market and to find optimal conditions for using it for high precision dosimetry. Materials and Methods: Irradiations were carried out using 60 Co gamma rays from an Eldorado irradiator. The dosimeters were sandwiched in a lucite phantom with 4.4 mm build-up and irradiated in the center of a 10 cm x 10 cm field at 1 meter from the source. The temperature during irradiations was 22 deg. C. The dose rate was about 0.68 Gy/min. Measurements of optical density were made using a Cary 210 spectrophotometer. A bandpass of 3.5 nm was used. The temperature of the baseplate of the sample holder was regulated to +/-0.05 deg. C and measured by a probe lying on the baseplate. In all cases, values of OD were only recorded after they had come to a constant value, which was reached within 5 minutes of inserting the dosimeter into the sample chamber of the spectrophotometer. Results: The temperature dependence of the OD at 676 nm was measured in 2 studies using 6 dosimeters that had received 0, 1.0, 3.5, 6.2, 14.5 Gy. Readings were taken at 7 temperatures between 18.8 and 28.1 deg. C. By returning to the initial temperature several hours later, it was found

  4. Rapid prototyping and evaluation of programmable SIMD SDR processors in LISA

    Science.gov (United States)

    Chen, Ting; Liu, Hengzhu; Zhang, Botao; Liu, Dongpei

    2013-03-01

    With the development of international wireless communication standards, there is an increase in computational requirement for baseband signal processors. Time-to-market pressure makes it impossible to completely redesign new processors for the evolving standards. Due to its high flexibility and low power, software defined radio (SDR) digital signal processors have been proposed as promising technology to replace traditional ASIC and FPGA fashions. In addition, there are large numbers of parallel data processed in computation-intensive functions, which fosters the development of single instruction multiple data (SIMD) architecture in SDR platform. So a new way must be found to prototype the SDR processors efficiently. In this paper we present a bit-and-cycle accurate model of programmable SIMD SDR processors in a machine description language LISA. LISA is a language for instruction set architecture which can gain rapid model at architectural level. In order to evaluate the availability of our proposed processor, three common baseband functions, FFT, FIR digital filter and matrix multiplication have been mapped on the SDR platform. Analytical results showed that the SDR processor achieved the maximum of 47.1% performance boost relative to the opponent processor.

  5. Compact laser interferometer for translation and tilt measurement as optical readout for the LISA inertial sensor

    Science.gov (United States)

    Schuldt, Thilo; Gohlke, Martin; Weise, Dennis; Johann, Ulrich; Peters, Achim; Braxmaier, Claus

    2007-10-01

    The space mission LISA (Laser Interferometer Space Antenna) aims at detecting gravitational waves in the frequency range 30 μ Hz to 1Hz. Free flying proof masses inside the satellites act as inertial sensors and represent the end mirrors of the interferometer. In the current baseline design, LISA utilizes an optical readout of the position and tilt of the proof mass with respect to the satellite housing. This readout must have ~ 5pm/√Hz sensitivity for the translation measurement (for frequencies above 2.8mHz with an ƒ -2 relaxation down to 30 μHz) and ~ 10 nrad/√Hz sensitivity for the tilt measurement (for frequencies above 0.1mHz with an ƒ -1 relaxation down to 30 μHz). The University of Applied Sciences Konstanz (HTWG) - in collaboration with Astrium GmbH, Friedrichshafen, and the Humboldt-University Berlin - therefore develops a highly symmetric heterodyne interferometer implementing differential wavefront sensing for the tilt measurement. We realized a mechanically highly stable and compact setup. In a second, improved setup we measured initial noise levels below 5 pm/√Hz and 10 nrad/√Hz, respectively, for frequencies above 10mHz.

  6. Principles, operations, and expected performance of the LISA Pathfinder charge management system

    Energy Technology Data Exchange (ETDEWEB)

    Ziegler, T [Astrium GmbH, 88039 Friedrichshafen (Germany); Fichter, W [iFR, Universitaet Stuttgart, Pfaffenwaldring 7a, 70569 Stuttgart (Germany); Schulte, M [Blackett Laboratory, Imperial College, Prince Consort Road, London SW7 2BZ (United Kingdom); Vitale, S, E-mail: tobias.ziegler@astrium.eads.ne [Department of Physics, University of Trento, 38050 Povo, Trento (Italy)

    2009-03-01

    The test masses of LISA Pathfinder are free flying and therefore not grounded to the spacecraft by a wire. Because of galactic cosmic rays, solar energetic particles, and unknown microscopic surface effects during initial test mass release, an unacceptable level of absolute charge might be present on the test masses. A charged test mass can endanger transition to high accuracy control modes which are required for science experiments. Furthermore, charged test masses introduce unwanted disturbance accelerations for example due to Coulomb interactions with surrounding conducting surfaces. The charge management system is designed to discharge the test masses up to a tolerable level of absolute charge such that the mission goal can be achieved. It is therefore an essential part of the experiments to be performed with the LISA Technology Package. The paper describes charge management tasks to be performed on board the spacecraft and summarizes the principles of charge measurement and discharge control. An overview of the experiment operations is given where the interconnection of operational charge management system modes and operational modes of the drag-free, suspension and attitude control system is considered. Simulated performance results are presented.

  7. LISA time-delay interferometry zero-signal solution: Geometrical properties

    International Nuclear Information System (INIS)

    Tinto, Massimo; Larson, Shane L.

    2004-01-01

    Time-delay interferometry (TDI) is the data processing technique needed for generating interferometric combinations of data measured by the multiple Doppler readouts available onboard the three Laser Interferometer Space Antenna (LISA) spacecraft. Within the space of all possible interferometric combinations TDI can generate, we have derived a specific combination that has zero response to the gravitational wave signal, and called it the zero-signal solution (ZSS). This is a two-parameter family of linear combinations of the generators of the TDI space, and its response to a gravitational wave becomes null when these two parameters coincide with the values of the angles of the source location in the sky. Remarkably, the ZSS does not rely on any assumptions about the gravitational waveform, and in fact it works for waveforms of any kind. Our approach is analogous to the data analysis method introduced by Guersel and Tinto in the context of networks of Earth-based, wideband, interferometric gravitational wave detectors observing in coincidence a gravitational wave burst. The ZSS should be regarded as an application of the Guersel and Tinto method to the LISA data

  8. Metal-amplified Density Assays, (MADAs), including a Density-Linked Immunosorbent Assay (DeLISA).

    Science.gov (United States)

    Subramaniam, Anand Bala; Gonidec, Mathieu; Shapiro, Nathan D; Kresse, Kayleigh M; Whitesides, George M

    2015-02-21

    This paper reports the development of Metal-amplified Density Assays, or MADAs - a method of conducting quantitative or multiplexed assays, including immunoassays, by using Magnetic Levitation (MagLev) to measure metal-amplified changes in the density of beads labeled with biomolecules. The binding of target analytes (i.e. proteins, antibodies, antigens) to complementary ligands immobilized on the surface of the beads, followed by a chemical amplification of the binding in a form that results in a change in the density of the beads (achieved by using gold nanoparticle-labeled biomolecules, and electroless deposition of gold or silver), translates analyte binding events into changes in density measureable using MagLev. A minimal model based on diffusion-limited growth of hemispherical nuclei on a surface reproduces the dynamics of the assay. A MADA - when performed with antigens and antibodies - is called a Density-Linked Immunosorbent Assay, or DeLISA. Two immunoassays provided a proof of principle: a competitive quantification of the concentration of neomycin in whole milk, and a multiplexed detection of antibodies against Hepatitis C virus NS3 protein and syphilis T. pallidum p47 protein in serum. MADAs, including DeLISAs, require, besides the requisite biomolecules and amplification reagents, minimal specialized equipment (two permanent magnets, a ruler or a capillary with calibrated length markings) and no electrical power to obtain a quantitative readout of analyte concentration. With further development, the method may be useful in resource-limited or point-of-care settings.

  9. Parasites and hepatic histopathological lesions in lisa (Mugil incilis from Totumo mash, North of Colombia

    Directory of Open Access Journals (Sweden)

    Jesús Olivero V.

    2013-03-01

    Full Text Available Objective. To assess the levels of parasitism by nematodes and trematodes, as well as the hepatic histopathological alterations present in Mugil incilis (Lisa from Totumo marsh, North of Colombia. Materials and methods. Between July 2004 and June 2005, 500 fish were collected at Totumo Marsh (75°16’W and 10°44´N, North of Colombia. Morphometric and parasitic parameters were determined for each specimen, and the hepatic histopathological status of the liver was assessed by analyzing liver slides stained with hematoxylin and eosin. Results. Nematode larvae isolated from Mugil incilis corresponded to Contracaecum spp. Parasite prevalence was 60.49%. Parasitic mean abundance and mean intensity were 4.8±1.05 and 7.02±1.49, nematodes per fish, respectively. The correlation between nematode mean abundance and fish length was significant and positive (r=0.525, p<0.0001, but negative for condition factor (r=-0.109, p=0.014. Hepatic histopathological analysis revealed the presence of encapsulated trematode larvae as the main finding. However, the presence of inflammation, granulomas, steatosis and necrosis, were also registered as secondary alterations. Conclusions. Lisas collected at Totumo Marsh are parasitized with nematodes and trematodes. These fish have different histopathological lesions in the liver tissue, being the most important the presence of trematode encapsulated cyst that generate inflammatory reactions, and negatively correlate with morphometric markers of fish health.

  10. Constraints on LISA Pathfinder's Self-Gravity: Design Requirements, Estimates and Testing Procedures

    Science.gov (United States)

    Armano, M.; Audley, H.; Auger, G.; Baird, J.; Binetruy, P.; Born, M.; Bortoluzzi, M.; Brandt, Nico; Bursi, Alessandro; Slutsky. J.; hide

    2016-01-01

    LISA Pathfinder satellite was launched on 3 December 2015 toward the Sun Earth first Lagrangian point (L1) where the LISA Technology Package (LTP), which is the main science payload, will be tested. LTP achieves measurements of differential acceleration of free-falling test masses (TMs) with sensitivity below 3 x 10(exp -14) m s(exp -2) Hz(exp - 1/2) within the 130 mHz frequency band in one dimension. The spacecraft itself is responsible for the dominant differential gravitational field acting on the two TMs. Such a force interaction could contribute a significant amount of noise and thus threaten the achievement of the targeted free-fall level. We prevented this by balancing the gravitational forces to the sub nm s(exp -2) level, guided by a protocol based on measurements of the position and the mass of all parts that constitute the satellite, via finite element calculation tool estimates. In this paper, we will introduce the gravitational balance requirements and design, and then discuss our predictions for the balance that will be achieved in flight.

  11. Simulation of the charging process of the LISA test masses due to solar flares

    International Nuclear Information System (INIS)

    Vocca, H; Grimani, C; Amico, P; Bosi, L; Marchesoni, F; Punturo, M; Travasso, F; Barone, M; Stanga, R; Vetrano, F; Vicere, A

    2004-01-01

    Cosmic-ray and solar high energy particles penetrate the LISA experiment test masses. Consequently, an electric charge accumulates in the bodies of the masses, generating spurious Coulomb forces between the masses and the surrounding electrodes. This process increases the noise level of the experiment. We have estimated the amount of charge deposited per second on the LISA test masses by solar flares and primary cosmic-ray protons at solar minimum. The simulation has been carried out with the Fluka Monte Carlo program. A simplified geometry for the experiment has been considered. We have found a net charging rate of 37 ± 1 e + /s for primary protons at solar minimum between 0.1 and 1000 GeV/n. The amount of charge released by a medium-strong solar flare, like that of 16 February 1984, is 10 732 ± 30 e + /s in the energy range 0.1-10 GeV/n. This value increases or decreases by approximately one order of magnitude for strong (weak) solar flares

  12. Science with the space-based interferometer eLISA. II. Gravitational waves from cosmological phase transitions

    International Nuclear Information System (INIS)

    Caprini, Chiara; Hindmarsh, Mark; Helsinki Univ.; Huber, Stephan

    2016-04-01

    We investigate the potential for the eLISA space-based interferometer to detect the stochastic gravitational wave background produced by strong first-order cosmological phase transitions. We discuss the resulting contributions from bubble collisions, magnetohydrodynamic turbulence, and sound waves to the stochastic background, and estimate the total corresponding signal predicted in gravitational waves. The projected sensitivity of eLISA to cosmological phase transitions is computed in a model-independent way for various detector designs and configurations. By applying these results to several specific models, we demonstrate that eLISA is able to probe many well-motivated scenarios beyond the Standard Model of particle physics predicting strong first-order cosmological phase transitions in the early Universe.

  13. Preparing MD-PhD students for clinical rotations: navigating the interface between PhD and MD training.

    Science.gov (United States)

    Goldberg, Charles; Insel, Paul A

    2013-06-01

    Many aspects of MD-PhD training are not optimally designed to prepare students for their future roles as translational clinician-scientists. The transition between PhD research efforts and clinical rotations is one hurdle that must be overcome. MD-PhD students have deficits in clinical skills compared with those of their MD-only colleagues at the time of this transition. Reimmersion programs (RPs) targeted to MD-PhD students have the potential to help them navigate this transition.The authors draw on their experience creating and implementing an RP that incorporates multiple types of activities (clinical exam review, objective structured clinical examination, and supervised practice in patient care settings) designed to enhance the participants' skills and readiness for clinical efforts. On the basis of this experience, they note that MD-PhD students' time away from the clinical environment negatively affects their clinical skills, causing them to feel underprepared for clinical rotations. The authors argue that participation in an RP can help students feel more comfortable speaking with and examining patients and decrease their anxiety regarding clinical encounters. The authors propose that RPs can have positive outcomes for improving the transition from PhD to clinical MD training in dual-degree programs. Identifying and addressing this and other transitions need to be considered to improve the educational experience of MD-PhD students.

  14. EDITORIAL: Proceedings of the 7th International LISA Symposium, Barcelona, Spain, 16-20 June 2008 Proceedings of the 7th International LISA Symposium, Barcelona, Spain, 16-20 June 2008

    Science.gov (United States)

    Lobo, Alberto; Sopuerta, Carlos F.

    2009-05-01

    In June 2006 the LISA International Science Team (LIST) accepted the bid presented by the Institut d'Estudis Espacials de Catalunya (IEEC) to host the 7th International LISA Symposium. This was during its 11th meeting at the University of Maryland, just before the 6th edition of the symposium started at NASA's Goddard Space Flight Center. The 7th International LISA Symposium took place in the city of Barcelona, Spain, 16-20 June, 2008, in the premises of CosmoCaixa, a modern science museum located in the hills near Tibidabo. Almost 240 delegates registered for the event, a record breaking figure compared to previous editions of the symposium. Many of the most renowned world experts in LISA, gravitational wave science, and astronomy, as well as engineers, attended LISA #7 and produced state of the art presentations, while everybody benefited from the opportunity to have live discussions during the week in a friendly environment. The programme included 31 invited plenary lectures in the mornings, and eight parallel sessions in the afternoons. These were classified into seven major areas of research: LISA Technology, LISA PathFinder, LISA PathFinder Data Analysis, LISA Data Analysis, Gravitational Wave Sources, Cosmology and Fundamental Physics with LISA and Other Gravitational Wave Detectors. Abstracts for 138 communications were received, from which a selection was made by the session convenors which would fit time constraints. Up to 63 posters completed the scientific programme. More details on the programme, including some of the talks, can be found at the symposium website:http://www.ice.cat/research/LISA_Symposium. There was, however, a remarkable add-on: Professor Clifford Will delivered a startling presentation to the general public, who completely filled the Auditori—the main conference room, 320 seats—and were invited to ask questions to the speaker who boldly guided them through the daunting world of Black Holes, Waves of Gravity, and other Warped Ideas

  15. 75 FR 80744 - Airworthiness Directives; McDonnell Douglas Corporation Model DC-9-81 (MD-81), DC-9-82 (MD-82...

    Science.gov (United States)

    2010-12-23

    ...-1203; Directorate Identifier 2010-NM-168-AD] RIN 2120-AA64 Airworthiness Directives; McDonnell Douglas... amends Sec. 39.13 by adding the following new airworthiness directive (AD): McDonnell Douglas Corporation... Douglas Corporation Model DC-9-81 (MD-81), DC-9-82 (MD-82), DC-9-83 (MD-83), DC-9-87 (MD-87) and MD-88...

  16. Md-miR156ab and Md-miR395 Target WRKY Transcription Factors to Influence Apple Resistance to Leaf Spot Disease.

    Science.gov (United States)

    Zhang, Qiulei; Li, Yang; Zhang, Yi; Wu, Chuanbao; Wang, Shengnan; Hao, Li; Wang, Shengyuan; Li, Tianzhong

    2017-01-01

    MicroRNAs (miRNAs) are key regulators of gene expression that post-transcriptionally regulate transcription factors involved in plant physiological activities. Little is known about the effects of miRNAs in disease resistance in apple ( Malus × domestica ). We globally profiled miRNAs in the apple cultivar Golden Delicious (GD) infected or not with the apple leaf spot fungus Alternaria alternaria f. sp. mali (ALT1), and identified 58 miRNAs that exhibited more than a 2-fold upregulation upon ALT1 infection. We identified a pair of miRNAs that target protein-coding genes involved in the defense response against fungal pathogens; Md-miR156ab targets a novel WRKY transcription factor, MdWRKYN1, which harbors a TIR and a WRKY domain. Md-miR395 targets another transcription factor, MdWRKY26, which contains two WRKY domains. Real-time PCR analysis showed that Md-miR156ab and Md-miR395 levels increased, while MdWRKYN1 and MdWRKY26 expression decreased in ALT1-inoculated GD leaves; furthermore, the overexpression of Md-miR156ab and Md-miR395 resulted in a significant reduction in MdWRKYN1 and MdWRKY26 expression. To investigate whether these miRNAs and their targets play a crucial role in plant defense, we overexpressed MdWRKYN1 or knocked down Md-miR156ab activity, which in both cases enhanced the disease resistance of the plants by upregulating the expression of the WRKY-regulated pathogenesis-related (PR) protein-encoding genes MdPR3-1, MdPR3-2, MdPR4, MdPR5, MdPR10-1 , and MdPR10-2 . In a similar analysis, we overexpressed MdWRKY26 or suppressed Md-miR395 activity, and found that many PR protein-encoding genes were also regulated by MdWRKY26 . In GD, ALT-induced Md-miR156ab and Md-miR395 suppress MdWRKYN1 and MdWRKY26 expression, thereby decreasing the expression of some PR genes, and resulting in susceptibility to ALT1.

  17. The low emittance 2.5 GeV synchrotron light source LISA

    International Nuclear Information System (INIS)

    Einfeld, D.; Hormes, J.; Husmann, D.

    1992-01-01

    LISA, a Light source for Industrial and Scientific Applications, has been proposed. Due to the intention to use the source above all for the LIGA (Lithographie, Galvanik, Abformtechnik) method to produce micromechanical structures, the critical wavelength of the synchrotron radiation spectrum is foreseen to be 0.2 nm. Therefore, the electron energy and the field strength of the ring dipoles have been chosen to be 2.5 GeV and 1.5 T, respectively. It is proposed to make use of a modified 'quadrupole ben achromat' (QBA) lattice. The novel feature of this lattice is the application of two types of bending magnets of different lengths, i.e. different bending angels. (author) 9 refs.; 6 figs.; 1 tab

  18. Metaphors Expressing Emotions in Lisa Kleypas’s Rainshadow Road Novel

    Directory of Open Access Journals (Sweden)

    Novi Liana Ko

    2014-05-01

    Full Text Available Metaphors have been always interesting to explore since they are able to represent many things, one of which is feelings. Article examined the metaphorical sentences which expressed emotions found in Lisa Kleypas’s the Rainshadow Road. Library research was conducted to find the kinds of emotions which were expressed by the metaphorical sentences. It was also done to figure out what the metaphors refered to. Another objective was to reveal the most dominant emotion which appeared through the metaphors expressed in the novel. The analysis used metaphor theory to compare the dictionary meaning and the metaphorical one. The result shows that there are various emotions which are expressed through the metaphorical sentences. Happiness is found as the most dominant emotion which appears in the novel.

  19. Actuation stability test of the LISA pathfinder inertial sensor front-end electronics

    Science.gov (United States)

    Mance, Davor; Gan, Li; Weber, Bill; Weber, Franz; Zweifel, Peter

    In order to limit the residual stray forces on the inertial sensor test mass in LISA pathfinder, √ it is required that the fluctuation of the test mass actuation voltage is within 2ppm/ Hz. The actuation voltage stability test on the flight hardware of the inertial sensor front-end electronics (IS FEE) is presented in this paper. This test is completed during the inertial sensor integration at EADS Astrium Friedrichshafen, Germany. The standard measurement method using voltmeter is not sufficient for verification, since the instrument low frequency √ fluctuation is higher than the 2ppm/ Hz requirement. In this test, by using the differential measurement method and the lock-in amplifier, the actuation stability performance is verified and the quality of the IS FEE hardware is confirmed by the test results.

  20. Inference on white dwarf binary systems using the first round Mock LISA Data Challenges data sets

    International Nuclear Information System (INIS)

    Stroeer, Alexander; Veitch, John; Roever, Christian; Bloomer, Ed; Clark, James; Christensen, Nelson; Hendry, Martin; Messenger, Chris; Meyer, Renate; Pitkin, Matthew; Toher, Jennifer; Umstaetter, Richard; Vecchio, Alberto; Woan, Graham

    2007-01-01

    We report on the analysis of selected single source data sets from the first round of the mock LISA data challenges (MLDC) for white dwarf binaries. We implemented an end-to-end pipeline consisting of a grid-based coherent pre-processing unit for signal detection and an automatic Markov Chain Monte Carlo (MCMC) post-processing unit for signal evaluation. We demonstrate that signal detection with our coherent approach is secure and accurate, and is increased in accuracy and supplemented with additional information on the signal parameters by our Markov Chain Monte Carlo approach. We also demonstrate that the Markov Chain Monte Carlo routine is additionally able to determine accurately the noise level in the frequency window of interest

  1. Auxiliary functions of the LISA laser link: ranging, clock noise transfer and data communication

    International Nuclear Information System (INIS)

    Heinzel, Gerhard; Esteban, Juan Jose; Barke, Simon; Otto, Markus; Wang Yan; Garcia, Antonio F; Danzmann, Karsten

    2011-01-01

    The Laser Interferometer Space Antenna (LISA) is required to reduce two important noise sources by post-processing on the ground using time-delay interferometry (TDI): phase noise of the on-board reference clocks and laser frequency noise. To achieve the desired suppression, the TDI algorithm needs measurements of the differential clock noise between any two spacecraft and inter-spacecraft ranging measurements with at least 1 m accuracy, which is beyond the precision of ground-based measurements for deep space missions. Therefore, we need on-board measurements by transmitting clock noise and ranging information between the spacecraft as auxiliary functions of the laser link. This paper reports our current experimental results in clock noise transfer and ranging for noise subtraction via post-processing as well as additional data transfer.

  2. Massive Black Hole Mergers: Can we see what LISA will hear?

    Science.gov (United States)

    Centrella, Joan

    2009-01-01

    Coalescing massive black hole binaries are formed when galaxies merge. The final stages of this coalescence produce strong gravitational wave signals that can be detected by the space-borne LISA. When the black holes merge in the presence of gas and magnetic fields, various types of electromagnetic signals may also be produced. Modeling such electromagnetic counterparts requires evolving the behavior of both gas and fields in the strong-field regions around the black holes. We have taken a first step towards this problem by mapping the flow of pressureless matter in the dynamic, 3-D general relativistic spacetime around the merging black holes. We report on the results of these initial simulations and discuss their likely importance for future hydrodynamical simulations.

  3. eLISA Telescope In-field Pointing and Scattered Light Study

    Science.gov (United States)

    Livas, J.; Sankar, S.; West, G.; Seals, L.; Howard, J.; Fitzsimons, E.

    2017-05-01

    The orbital motion of the three spacecraft that make up the eLISA Observatory constellation causes long-arm line of sight variations of approximately ± one degree over the course of a year. The baseline solution is to package the telescope, the optical bench, and the gravitational reference sensor (GRS) into an optical assembly at each end of the measurement arm, and then to articulate the assembly. An optical phase reference is exchanged between the moving optical benches with a single mode optical fiber (“backlink” fiber). An alternative solution, referred to as in-field pointing, embeds a steering mirror into the optical design, fixing the optical benches and eliminating the backlink fiber, but requiring the additional complication of a two-stage optical design for the telescope. We examine the impact of an in-field pointing design on the scattered light performance.

  4. A constrained Metropolis-Hastings search for EMRIs in the Mock LISA Data Challenge 1B

    International Nuclear Information System (INIS)

    Gair, Jonathan R; Porter, Edward; Babak, Stanislav; Barack, Leor

    2008-01-01

    We describe a search for the extreme-mass-ratio inspiral sources in the Round 1B Mock LISA Data Challenge data sets. The search algorithm is a Monte Carlo search based on the Metropolis-Hastings algorithm, but also incorporates simulated, thermostated and time annealing, plus a harmonic identification stage designed to reduce the chance of the chain locking onto secondary maxima. In this paper, we focus on describing the algorithm that we have been developing. We give the results of the search of the Round 1B data, although parameter recovery has improved since that deadline. Finally, we describe several modifications to the search pipeline that we are currently investigating for incorporation in future searches

  5. Bell's palsy: the answer to the riddle of Leonardo da Vinci's 'Mona Lisa'.

    Science.gov (United States)

    Maloney, W J

    2011-05-01

    The smile of the famed portrait 'The Mona Lisa' has perplexed both art historians and researchers for the past 500 years. There has been a multitude of theories expounded to explain the nature of the model's enigmatic smile. The origin of the model's wry smile can be demonstrated through a careful analysis of both documented facts concerning the portrait--some gathered only recently through the use of modern technology--and a knowledge of the clinical presentation of Bell's palsy. Bell's palsy is more prevalent in women who are either pregnant or who have recently given birth. This paper postulates that the smile of the portrait's model was due to Leonardo da Vinci's anatomically precise representation of a new mother affected by Bell's palsy subsequent to her recent pregnancy.

  6. Selective metallization of polymers using laser induced surface activation (LISA)—characterization and optimization of porous surface topography

    DEFF Research Database (Denmark)

    Zhang, Yang; Hansen, Hans Nørgaard; De Grave, Arnaud

    2011-01-01

    Laser induced selective activation (LISA) is a molded interconnected devices technique for selective metallization of polymers. On the working piece, only the laser-machined area can be metalized in the subsequent plating. The principle of the technology is introduced. Surface analysis was perfor...

  7. Simple Enough--Even for Web Virgins: Lisa Mitten's Access to Native American Web Sites. Web Site Review Essay.

    Science.gov (United States)

    Belgarde, Mary Jiron

    1998-01-01

    A mixed-blood Mohawk urban Indian and university librarian, Lisa Mitten provides access to Web sites with solid information about American Indians. Links are provided to 10 categories--Native nations, Native organizations, Indian education, Native media, powwows and festivals, Indian music, Native arts, Native businesses, and Indian-oriented home…

  8. Search for a stochastic gravitational-wave signal in the second round of the Mock LISA Data Challenges

    International Nuclear Information System (INIS)

    Robinson, E L; Vecchio, A; Romano, J D

    2008-01-01

    The analysis method currently proposed to search for isotropic stochastic radiation with the Laser Interferometer Space Antenna (LISA) relies on the combined use of two LISA channels, one of which is insensitive to gravitational waves, such as the symmetrized Sagnac. For this method to work, it is essential to know how the instrumental noise power in the two channels are related to one another; however, no quantitative estimates of this key information are available to date. The purpose of our study is to assess the performance of the symmetrized Sagnac method for different levels of prior information regarding the instrumental noise. We develop a general approach in the framework of Bayesian inference and an end-to-end analysis algorithm based on Markov chain Monte Carlo methods to compute the posterior probability density functions of the relevant model parameters. We apply this method to data released as part of the second round of the Mock LISA Data Challenges. For the selected (and somewhat idealized) example cases considered here, we find that for a signal whose amplitude dominates the instrumental noise by a factor ∼25, a prior uncertainty of a factor ∼2 in the ratio between the power of the instrumental noise contributions in the two channels allows for the detection of isotropic stochastic radiation. More importantly, we provide a framework for more realistic studies of LISA's performance and development of analysis techniques in the context of searches for stochastic signals

  9. Playing Harry Potter: Essays and interviews on fandom and performance, edited by Lisa S. Brenner [book review

    Directory of Open Access Journals (Sweden)

    Abigail De Kosnik

    2016-09-01

    Full Text Available Review of Lisa S. Brenner, editor. Playing Harry Potter: Essays and interviews on fandom and performance. Jefferson, NC: McFarland, 2015, paperback, $29.95 (238p ISBN 978-0-7864-9657-0, e-book $14.43 (5374 KB ISBN 978-1-4766-2136-4, ASIN B012E9G0R6.

  10. Theory and modelling of the magnetic field measurement in LISA PathFinder

    Energy Technology Data Exchange (ETDEWEB)

    Diaz-Aguilo, M; Garcia-Berro, E [Departament de Fisica Aplicada, Universitat Politecnica de Catalunya, c/Esteve Terrades, 5, 08860 Castelldefels (Spain); Lobo, A, E-mail: marc.diaz.aguilo@fa.upc.ed [Institut d' Estudis Espacials de Catalunya, c/Gran Capita 2-4, Edif. Nexus 104, 08034 Barcelona (Spain)

    2010-02-07

    The magnetic diagnostics subsystem of the LISA Technology Package (LTP) on board the LISA PathFinder (LPF) spacecraft includes a set of four tri-axial fluxgate magnetometers, intended to measure with high precision the magnetic field at their respective positions. However, their readouts do not provide a direct measurement of the magnetic field at the positions of the test masses, and hence an interpolation method must be designed and implemented to obtain the values of the magnetic field at these positions. However, such an interpolation process faces serious difficulties. Indeed, the size of the interpolation region is excessive for a linear interpolation to be reliable while, on the other hand, the number of magnetometer channels do not provide sufficient data to go beyond the linear approximation. We describe an alternative method to address this issue, by means of neural network algorithms. The key point in this approach is the ability of neural networks to learn from suitable training data representing the behaviour of the magnetic field. Despite the relatively large distance between the test masses and the magnetometers, and the insufficient number of data channels, we find that our artificial neural network algorithm is able to reduce the estimation errors of the field and gradient down to levels below 10%, a quite satisfactory result. Learning efficiency can be best improved by making use of data obtained in on-ground measurements prior to mission launch in all relevant satellite locations and in real operation conditions. Reliable information on that appears to be essential for a meaningful assessment of magnetic noise in the LTP.

  11. Theory and modelling of the magnetic field measurement in LISA PathFinder

    International Nuclear Information System (INIS)

    Diaz-Aguilo, M; Garcia-Berro, E; Lobo, A

    2010-01-01

    The magnetic diagnostics subsystem of the LISA Technology Package (LTP) on board the LISA PathFinder (LPF) spacecraft includes a set of four tri-axial fluxgate magnetometers, intended to measure with high precision the magnetic field at their respective positions. However, their readouts do not provide a direct measurement of the magnetic field at the positions of the test masses, and hence an interpolation method must be designed and implemented to obtain the values of the magnetic field at these positions. However, such an interpolation process faces serious difficulties. Indeed, the size of the interpolation region is excessive for a linear interpolation to be reliable while, on the other hand, the number of magnetometer channels do not provide sufficient data to go beyond the linear approximation. We describe an alternative method to address this issue, by means of neural network algorithms. The key point in this approach is the ability of neural networks to learn from suitable training data representing the behaviour of the magnetic field. Despite the relatively large distance between the test masses and the magnetometers, and the insufficient number of data channels, we find that our artificial neural network algorithm is able to reduce the estimation errors of the field and gradient down to levels below 10%, a quite satisfactory result. Learning efficiency can be best improved by making use of data obtained in on-ground measurements prior to mission launch in all relevant satellite locations and in real operation conditions. Reliable information on that appears to be essential for a meaningful assessment of magnetic noise in the LTP.

  12. Elimination of vibrio cholerae in lisa fillets (Mugil cephalus) by gamma radiation

    International Nuclear Information System (INIS)

    Torres, Z.

    1999-03-01

    The elimination of Vibrio cholerae 01 biotype El Tor (1,87 8 cuf/g) in fresh lisa fillets (Mugil cephalus) with radiation doses of 0 and 0,5 kGy was investigated. Furthermore, in order to evaluate physical, chemical and sensory changes, doses of 1,2,3 and 4 kGy were applied to non inoculated fillets of lisa. Finally, D 10 for Vibrio cholerae was determined in a saline suspension (5,2x10 8 cfu/ml) based on the Most Probable Number (MPN) method and radiation doses of 0,5, 0,75, 1,0, 1,25 and 1,5 kGy. D value found in a 1,87 8 cfu/g concentration of fillet was 0,13 kGy. Humidity, protein, fat and ash contents were not affected significantly and remained around 73 to 75,5, 3,8 to 4,2 and 1% respectively. Control samples showed a 'drip' variation ranging between 0,82 and 0,88% and a N-BVT variation between 1,77 and 1,56, 0,89 and 1,99, 2,13 and 2,47, 1,86 and 2,10%, and a N-BVT variation between 17,79 and 30,16, 16,37 and 26,88 16,33 and 25,12, 15,31 and 33,54 mg N/100 g, respectively. The highest life span for the appearance characteristic was obtained by control samples (23 days) and the lowest by samples radiated at 3 and 4 kGy (28 days). 4 kGy dose resulted in organoleptic changes perceived by panelists during tasting of cooked fish. D 10 found in a saline suspension was 0,13 kGy

  13. Editorial. Special issue of Classical and Quantum Gravity on the proceedings of the 4th international LISA symposium

    International Nuclear Information System (INIS)

    Finn, Lee Samuel

    2003-01-01

    The 4th International LISA Symposium was held at the National Science Foundation Physics Frontier Center for Gravitational Wave Physics at The Pennsylvania State University on 19-24 July 2002. This special issue of Classical and Quantum Gravity is the proceedings of this meeting. LISA - the Laser Interferometer Space Antenna - is part of an international effort to open a new window on the universe. Not all things radiate light, but everything gravitates. Observations of the gravitational waves radiated by black holes and compact binary star systems, in our galaxy and beyond, can reveal details about these systems and their environments that are otherwise inaccessible. The international effort, of which LISA is a part, includes ground-based detectors, and the relationship between LISA and its ground-based detector 'cousins' was an important theme for this Symposium. LISA will observe gravitational waves in the 0.1 mHz to 0.1 Hz band, complementing observations made by ground-based detectors in the 10 Hz to several KHz band. Together they will explore nearly six decades of bandwidth in the gravitational-wave sky. LISA in particular will observe the gravitational waves radiated by the coalescence of black holes at the centres of colliding galaxies, and the inspiral of compact neutron stars or stellar-mass black holes onto these black holes, virtually anywhere in the universe. It will take a census of neutron star or close white dwarf binaries in our own galaxy and observe the formation of large black holes from the very first structures to form and collapse in our universe. In doing all these things, it will shed new 'light' on the first structures to form in the universe, explore the evolution of galaxies and the roles that black holes play in their structure, test relativity near the 'edges' of a black hole, and deepen our understanding of stellar and binary system evolution. A successful conference - and this LISA Symposium, like its predecessors, was very

  14. 3MdB: the Mexican Million Models database

    Science.gov (United States)

    Morisset, C.; Delgado-Inglada, G.

    2014-10-01

    The 3MdB is an original effort to construct a large multipurpose database of photoionization models. This is a more modern version of a previous attempt based on Cloudy3D and IDL tools. It is accessed by MySQL requests. The models are obtained using the well known and widely used Cloudy photoionization code (Ferland et al, 2013). The database is aimed to host grids of models with different references to identify each project and to facilitate the extraction of the desired data. We present here a description of the way the database is managed and some of the projects that use 3MdB. Anybody can ask for a grid to be run and stored in 3MdB, to increase the visibility of the grid and the potential side applications of it.

  15. Swiss national MD-PhD-program: an outcome analysis.

    Science.gov (United States)

    Kuehnle, Katrin; Winkler, David T; Meier-Abt, Peter J

    2009-09-19

    This study aims at a first evaluation of the outcome of the Swiss national MD-PhD program during the last 16 years. One hundred and twenty six former and current students in the Swiss national MD-PhD program were surveyed via a Web-based questionnaire in September 2007. Twenty-four questions assessed information regarding participant demographics, information on the PhD thesis and publication activity, current positions and research activity, as well as participant's opinions, attitudes and career goals. Eighty questionnaires were received from 126 MD-PhD students and graduates (63.5% response rate). The responders consisted of present students (36%), former graduates (56%), and dropouts (8%). The percentage of women in the program was 23%, and the average duration of the program was 4.2 +/- 1.4 years. Research interests were predominantly in the fields of neuroscience, immunology, molecular biology and cancer research. A considerable portion of the MD-PhD graduates had an excellent publication record stemming from their PhD research work, and 89% were planning to continue a research-orientated career. Over 50% of those MD-PhD graduates completing their thesis before 2002 had already reached an assistant or full professor position at the time of the survey. Nearly all participants considered the MD-PhD training helpful to their career and high quality standards were assigned to the acquired practical and intellectual skills. However, criticism was expressed concerning the general mentoring and the career related mentoring. Moreover, general mentoring and career related mentoring were significantly less well perceived in research groups employing more than seven PhD students at the same time. The MD-PhD students and graduates surveyed were satisfied with their education and most of them continued a research-orientated career. Regarding the overall positive evaluation, this study supports the view that MD-PhD graduates are well qualified for a successful career in

  16. MD 2179: Scraping of off-momentum halo after injection

    CERN Document Server

    Garcia Morales, Hector; Patecki, Marcin; Wretborn, Sven Joel; CERN. Geneva. ATS Department

    2018-01-01

    In this MD, a beam scraping was performed using the momentum primary collimator in IR3 where dispersion is high. A second scraping was performed using a TCSG in IR7 where dispersion is almost negligible. In such a way, we aim to disentangle the contribution of off-momentum particles to halo population. These scrapings will provide useful information to better understand the usual off-momentum losses we see at the start of the ramp. The MD results would also be used to benchmark simulations of off-momentum beam losses in order to gain confidence in simulation models.

  17. BayesMD: flexible biological modeling for motif discovery

    DEFF Research Database (Denmark)

    Tang, Man-Hung Eric; Krogh, Anders; Winther, Ole

    2008-01-01

    We present BayesMD, a Bayesian Motif Discovery model with several new features. Three different types of biological a priori knowledge are built into the framework in a modular fashion. A mixture of Dirichlets is used as prior over nucleotide probabilities in binding sites. It is trained on trans......We present BayesMD, a Bayesian Motif Discovery model with several new features. Three different types of biological a priori knowledge are built into the framework in a modular fashion. A mixture of Dirichlets is used as prior over nucleotide probabilities in binding sites. It is trained...

  18. Apple MdACS6 Regulates Ethylene Biosynthesis During Fruit Development Involving Ethylene-Responsive Factor.

    Science.gov (United States)

    Li, Tong; Tan, Dongmei; Liu, Zhi; Jiang, Zhongyu; Wei, Yun; Zhang, Lichao; Li, Xinyue; Yuan, Hui; Wang, Aide

    2015-10-01

    Ethylene biosynthesis in plants involves different 1-aminocyclopropane-1-carboxylic acid synthase (ACS) genes. The regulation of each ACS gene during fruit development is unclear. Here, we characterized another apple (Malus×domestica) ACS gene, MdACS6. The transcript of MdACS6 was observed not only in fruits but also in other tissues. During fruit development, MdACS6 was initiated at a much earlier stage, whereas MdACS3a and MdACS1 began to be expressed at 35 d before harvest and immediateley after harvest, respectively. Moreover, the enzyme activity of MdACS6 was significantly lower than that of MdACS3a and MdACS1, accounting for the low ethylene biosynthesis in young fruits. Overexpression of MdACS6 (MdACS6-OE) by transient assay in apple showed enhanced ethylene production, and MdACS3a was induced in MdACS6-OE fruits but not in control fruits. In MdACS6 apple fruits silenced by the virus-induced gene silencing (VIGS) system (MdACS6-AN), neither ethylene production nor MdACS3a transcript was detectable. In order to explore the mechanism through which MdACS3a was induced in MdACS6-OE fruits, we investigated the expression of apple ethylene-responsive factor (ERF) genes. The results showed that the expression of MdERF2 was induced in MdACS6-OE fruits and inhibited in MdACS6-AN fruits. Yeast one-hybrid assay showed that MdERF2 protein could bind to the promoter of MdACS3a. Moreover, down-regulation of MdERF2 in apple flesh callus led to a decrease of MdACS3a expression, demonstrating the regulation of MdERF2 on MdACS3a. The mechanism through which MdACS6 regulates the action of MdACS3a was discussed. © The Author 2015. Published by Oxford University Press on behalf of Japanese Society of Plant Physiologists. All rights reserved. For permissions, please email: journals.permissions@oup.com.

  19. Apple (Malus domestica) MdERF2 negatively affects ethylene biosynthesis during fruit ripening by suppressing MdACS1 transcription.

    Science.gov (United States)

    Li, Tong; Jiang, Zhongyu; Zhang, Lichao; Tan, Dongmei; Wei, Yun; Yuan, Hui; Li, Tianlai; Wang, Aide

    2016-12-01

    Ripening in climacteric fruit requires the gaseous phytohormone ethylene. Although ethylene signaling has been well studied, knowledge of the transcriptional regulation of ethylene biosynthesis is still limited. Here we show that an apple (Malus domestica) ethylene response factor, MdERF2, negatively affects ethylene biosynthesis and fruit ripening by suppressing the transcription of MdACS1, a gene that is critical for biosynthesis of ripening-related ethylene. Expression of MdERF2 was suppressed by ethylene during ripening of apple fruit, and we observed that MdERF2 bound to the promoter of MdACS1 and directly suppressed its transcription. Moreover, MdERF2 suppressed the activity of the promoter of MdERF3, a transcription factor that we found to bind to the MdACS1 promoter, thereby increasing MdACS1 transcription. We determined that the MdERF2 and MdERF3 proteins directly interact, and this interaction suppresses the binding of MdERF3 to the MdACS1 promoter. Moreover, apple fruit with transiently downregulated MdERF2 expression showed higher ethylene production and faster ripening. Our results indicate that MdERF2 negatively affects ethylene biosynthesis and fruit ripening in apple by suppressing the transcription of MdACS1 via multiple mechanisms, thereby acting as an antagonist of positive ripening regulators. Our findings offer a deep understanding of the transcriptional regulation of ethylene biosynthesis during climacteric fruit ripening. © 2016 The Authors The Plant Journal © 2016 John Wiley & Sons Ltd.

  20. Optical metrology alignment and impact on the measurement performance of the LISA Technology Package

    Energy Technology Data Exchange (ETDEWEB)

    Hirth, M; Fichter, W; Brandt, N; Gerardi, D [iFR, Universitaet Stuttgart, Pfaffenwaldring 7a, 70569 Stuttgart (Germany); Schleicher, A [Astrium GmbH, 88039 Friedrichshafen (Germany); Wanner, G, E-mail: marc.hirth@ifr.uni-stuttgart.d [Albert Einstein Institut, Callinstrasse 38, 30167 Hannover (Germany)

    2009-03-01

    Aside from LISA Pathfinder's top-level acceleration requirement, there is a stringent independent requirement for the accuracy of the optical metrology system. In case of a perfectly aligned metrology system (optical bench and test masses) it should rather be independent of residual displacement jitter due to control. However, this ideal case will not be achieved as mechanical tolerances and uncertainties lead to a direct impact of test mass and spacecraft displacement jitter on the optical measurement accuracy. In this paper, we present a strategy how to cover these effects for a systematic requirement breakdown. We use a simplified nonlinear geometrical model for the differential distance measurement of the test masses which is linearized and linked to the equations of motion for both the spacecraft and the two test masses. This leads from test mass relative displacement to a formulation in terms of applied force/torque and thus allows to distinguish the absolute motion of each of the three bodies. It further shows how motions in each degree of freedom couple linearly into the optical measurement via DC misalignments of the laser beam and the test masses. This finally allows for deriving requirements on the alignment accuracy of components and on permittable closed-loop acceleration noise. In the last part a budget for the expected measurement performance is compiled from simulations as no measurement data is available yet.

  1. The late inspiral of supermassive black hole binaries with circumbinary gas discs in the LISA band

    Science.gov (United States)

    Tang, Yike; Haiman, Zoltán; MacFadyen, Andrew

    2018-05-01

    We present the results of 2D, moving-mesh, viscous hydrodynamical simulations of an accretion disc around a merging supermassive black hole binary (SMBHB). The simulation is pseudo-Newtonian, with the BHs modelled as point masses with a Paczynski-Wiita potential, and includes viscous heating, shock heating, and radiative cooling. We follow the gravitational inspiral of an equal-mass binary with a component mass Mbh = 106 M⊙ from an initial separation of 60rg (where rg ≡ GMbh/c2 is the gravitational radius) to the merger. We find that a central, low-density cavity forms around the binary, as in previous work, but that the BHs capture gas from the circumbinary disc and accrete efficiently via their own minidiscs, well after their inspiral outpaces the viscous evolution of the disc. The system remains luminous, displaying strong periodicity at twice the binary orbital frequency throughout the entire inspiral process, all the way to the merger. In the soft X-ray band, the thermal emission is dominated by the inner edge of the circumbinary disc with especially clear periodicity in the early inspiral. By comparison, harder X-ray emission is dominated by the minidiscs, and the light curve is initially more noisy but develops a clear periodicity in the late inspiral stage. This variability pattern should help identify the electromagnetic counterparts of SMBHBs detected by the space-based gravitational-wave detector LISA.

  2. Optical metrology alignment and impact on the measurement performance of the LISA Technology Package

    International Nuclear Information System (INIS)

    Hirth, M; Fichter, W; Brandt, N; Gerardi, D; Schleicher, A; Wanner, G

    2009-01-01

    Aside from LISA Pathfinder's top-level acceleration requirement, there is a stringent independent requirement for the accuracy of the optical metrology system. In case of a perfectly aligned metrology system (optical bench and test masses) it should rather be independent of residual displacement jitter due to control. However, this ideal case will not be achieved as mechanical tolerances and uncertainties lead to a direct impact of test mass and spacecraft displacement jitter on the optical measurement accuracy. In this paper, we present a strategy how to cover these effects for a systematic requirement breakdown. We use a simplified nonlinear geometrical model for the differential distance measurement of the test masses which is linearized and linked to the equations of motion for both the spacecraft and the two test masses. This leads from test mass relative displacement to a formulation in terms of applied force/torque and thus allows to distinguish the absolute motion of each of the three bodies. It further shows how motions in each degree of freedom couple linearly into the optical measurement via DC misalignments of the laser beam and the test masses. This finally allows for deriving requirements on the alignment accuracy of components and on permittable closed-loop acceleration noise. In the last part a budget for the expected measurement performance is compiled from simulations as no measurement data is available yet.

  3. Picometer stable scan mechanism for gravitational wave detection in space: LISA PAAM

    Science.gov (United States)

    Pijnenburg, J. A. C. M.; Rijnveld, N.

    2017-11-01

    Detection and observation of gravitational waves requires extreme stability in the frequency range 0.03 mHz to 1 Hz. The Laser Interferometer Space Antenna (LISA) mission will attain this by creating a giant interferometer in space, based on free floating proof masses in three spacecrafts. Due to orbit evolution and time delay in the interferometer arms, the direction of transmitted light changes. To solve this problem, a picometer stable Point-Ahead Angle Mechanism (PAAM) was designed, realized and successfully tested. The PAAM concept is based on a rotatable mirror. The critical requirements are the contribution to the optical path length (less than 1.4 pm / rt Hz) and the angular jitter (less than 8 nrad / rt Hz). Extreme dimensional stability is achieved by manufacturing a monolithical Haberland hinge mechanism out of Ti6Al4V, through high precision wire erosion. Extreme thermal stability is realized by placing the thermal center on the surface of the mirror. Because of piezo actuator noise and leakage, the PAAM has to be controlled in closed-loop. To meet the requirements in the low frequencies, an active target capacitance-to-digital converter is used. Interferometric measurements with a triangular resonant cavity in vacuum proved that the PAAM meets the requirements.

  4. Testing and Characterization of a Prototype Telescope for the Evolved Laser Interferometer Space Antenna (eLISA)

    Science.gov (United States)

    Sankar, S.; Livas, J.

    2016-01-01

    We describe our efforts to fabricate, test and characterize a prototype telescope for the eLISA mission. Much of our work has centered on the modeling and measurement of scattered light performance. This work also builds on a previous demonstration of a high dimensional stability metering structure using particular choices of materials and interfaces. We will discuss ongoing plans to merge these two separate demonstrations into a single telescope design demonstrating both stray light and dimensional stability requirements simultaneously.

  5. The End of Panopticon/panopticism in William Gibson’s Mona Lisa Overdrive : A Baudrillardian Reading

    Directory of Open Access Journals (Sweden)

    Hanieh Zaltash

    2014-11-01

    Full Text Available This paper seeks to examine William Gibson’s Mona Lisa Overdrive as a cyberpunk novel in the light of Baudrillard’s theory of “Simulation”. Jean Baudrillard believes that reality is replaced by “hyperreality” and human beings live in a total “simulation” in which everything, such as power might be simulated. Thus, according to Baudrillard, power exists just as “the simulation of power” which is the result of “the circularization of power” between the dominator and the dominated. Baudrillard delineates “the circularization of power” through criticizing Michel Foucault’s theories regarding power and panopticon, and introduces “the end of panopticon” which is centered upon the reversibility of the positions of the observer and the observed. In a meticulous analysis of TV performance of the Loud family in 1971, Baudrillard claims that the panoptic system is ended through playing on the opposition of seeing and being seen. The findings suggest that Mona Lisa Overdrive depicts “the end of panopticon,” in a sense that Angie Mitchell in this novel can be considered as a counterpart for Baudrillard’s instance of the Loud family. Indeed, this study attempts to elucidate “the end of panopticon” in Mona Lisa Overdrive (1988 through scrutinizing Angie Mitchell’s way of living.

  6. 76 FR 51887 - Safety Zone; Patuxent River, Patuxent River, MD

    Science.gov (United States)

    2011-08-19

    ...-AA00 Safety Zone; Patuxent River, Patuxent River, MD AGENCY: Coast Guard, DHS. ACTION: Temporary final rule. SUMMARY: The Coast Guard is establishing a temporary safety zone during the ``NAS Patuxent River... held over certain waters of the Patuxent River adjacent to Patuxent River, Maryland from September 1...

  7. Thomas Secker M.D.: Archbishop and man-midwife.

    Science.gov (United States)

    Morgan-Guy, John

    2018-05-01

    This paper provides a biographical outline of the career of Thomas Secker, MD, who from 1758-68 was Archbishop of Canterbury. Although much has been written on Secker, this study seeks to highlight his training in medicine, which has been largely overlooked hitherto by historians.

  8. A pilot study of MD (psychiatry) theses-based research.

    Science.gov (United States)

    Srivastava, Shrikant; Agarwal, Vivek; Subramanyam, Alka; Srivastava, Mona; Sathyanarayana Rao, T S; Rao, G Prasad; Khurana, Hitesh; Singh, Archana

    2018-01-01

    Undertaking a research project is mandatory for MD Psychiatry trainees. The present study was undertaken to assess the type of research activity being undertaken as part of MD Psychiatry dissertation, and its contribution to national and international literature. Three medical colleges supplied the data about the topic, names of the supervisor and the candidate, collaboration, funding accrued, and publication details of MD-based research carried out between years 2000 and 2010 inclusive; 95 records were collected for the final analysis. The details of the publications provided were cross-checked on the internet, which would have taken care of missed publications as well. Most studies were single-point assessment clinical studies. Only 2 studies had been funded, 11 had collaboration with other departments within the same institute, and 5 had inter-institute collaborations. Majority of the studies were not published. Only 30 were published as full paper and 9 as abstracts. Of these 30 full publications, only 3 were published in journals having JCI impact factor values (1.4, 1.3, and 1.4, respectively). The main finding of this pilot study was that MD-based research has low contribution to the national and international literature, and those articles which are published are in low impact journals. Suggestions for modifying this state of affairs are discussed.

  9. Find an Orthopaedic Foot and Ankle MD/DO

    Science.gov (United States)

    ... All Site Content AOFAS / FootCareMD / Find a Surgeon Find a Foot & Ankle Orthopaedic Surgeon Page Content Who ... your prescribed treatment (surgical and/or non-surgical) ​ Find a Surgeon ​ Click here to find a foot ...

  10. Developing improved MD codes for understanding processive cellulases

    International Nuclear Information System (INIS)

    Crowley, M F; Nimlos, M R; Himmel, M E; Uberbacher, E C; Iii, C L Brooks; Walker, R C

    2008-01-01

    The mechanism of action of cellulose-degrading enzymes is illuminated through a multidisciplinary collaboration that uses molecular dynamics (MD) simulations and expands the capabilities of MD codes to allow simulations of enzymes and substrates on petascale computational facilities. There is a class of glycoside hydrolase enzymes called cellulases that are thought to decrystallize and processively depolymerize cellulose using biochemical processes that are largely not understood. Understanding the mechanisms involved and improving the efficiency of this hydrolysis process through computational models and protein engineering presents a compelling grand challenge. A detailed understanding of cellulose structure, dynamics and enzyme function at the molecular level is required to direct protein engineers to the right modifications or to understand if natural thermodynamic or kinetic limits are in play. Much can be learned about processivity by conducting carefully designed molecular dynamics (MD) simulations of the binding and catalytic domains of cellulases with various substrate configurations, solvation models and thermodynamic protocols. Most of these numerical experiments, however, will require significant modification of existing code and algorithms in order to efficiently use current (terascale) and future (petascale) hardware to the degree of parallelism necessary to simulate a system of the size proposed here. This work will develop MD codes that can efficiently use terascale and petascale systems, not just for simple classical MD simulations, but also for more advanced methods, including umbrella sampling with complex restraints and reaction coordinates, transition path sampling, steered molecular dynamics, and quantum mechanical/molecular mechanical simulations of systems the size of cellulose degrading enzymes acting on cellulose

  11. Eventos adversos temporalmente asociados a VAMENGOC- BC®. Municipio La Lisa, 1998-1999

    Directory of Open Access Journals (Sweden)

    Iván Edelberto Cuevas

    2000-12-01

    Full Text Available Con el objetivo de describir la frecuencia de eventos temporalmente asociados a la vacuna cubana VAMENGOC- BC®, se realizó un estudio observacional de tipo descriptivo, cuyo universo estuvo constituido por los lactantes en las edades comprendidas de tres (3549 y cinco meses (3832 de edad de las áreas de salud del Municipio La Lisa en Ciudad de La Habana. Hubo un 3,21% de niños con eventos adversos, con una mayor frecuencia después de la primera dosis; sin diferencias apreciables por sexo. La clasificación fue de un 52% de tipo sistémico, locales un 19% y no solicitados un 29%. La mayor parte de los niños afectados fue en las primeras 72 horas posteriores a la vacunación, y desaparecieron antes de 72 horas desde su comienzo. Las manifestaciones más frecuentes fueron fiebre (predominó entre todos los eventos adversos con 1,53 casos por 100 vacunados; la induración (0,31 por 100 vacunados, eritema (0,30 por 100 vacunados y el dolor (0,136 por 100 vacunados en el sitio de administración de la vacuna; irritabilidad (0,244 por 100 vacunados y pérdida de apetito (0,311 por 100 vacunados. Los eventos no solicitados más frecuentes fueron la Enfermedad Respiratoria Aguda (0,637 por 100 vacunados, la Enfermedad Diarreica Aguda (0,311 por 100 vacunados y la Otitis Media (0,176 por 100 vacunados. Los eventos adversos serios fueron infrecuentes. No hubo fallecidos y todos los casos se recuperaron en menos de diez días, sin secuelas, discapacidades ni minusvalías

  12. MD210 Note: Creation of Hollow Bunches in the PSB

    CERN Document Server

    Oeftiger, Adrian; Findlay, Alan James; Hancock, Steven; Rumolo, Giovanni; CERN. Geneva. ATS Department

    2016-01-01

    MD210 aims for the creation of longitudinally hollow bunches in the CERN PS Booster. The first three sessions have been carried out using the radial loop feedback system in order to drive the beam on a dipolar parametric resonance (instead of the phase loop). It has been found that the damping by the phase loop inhibits the excitation of the resonance to a major extent. The hollow distributions generated under these circumstances fail to reach a satisfying bunching factor. Nonetheless, proving the principally successful application of this technique to the PS Booster promises good results once the phase loop system supports trim functions. The approach, actions and detailed results of the first three MD sessions are presented in this paper.

  13. Postgraduate research training: the PhD and MD thesis.

    Science.gov (United States)

    Higginson, I; Corner, J

    1996-04-01

    Higher research degrees, such as the PhD, MPhil and MD, have existed within universities for 80 years or more, although the differences between the MD and PhD remain confused. A higher research degree training provides individuals with greater research knowledge and skills, and benefits the specialty. Concern exists about the levels of supervision sometimes provided, failure to complete degrees, and the variable levels of research knowledge and skills attained. We propose that higher research degrees in palliative care have four functions: extending personal scholarship, generating knowledge, training for the individual and contributing to the growth of the specialty. Such an approach may include: a formalised first year with taught components such as in research MSc programmes, formal supervision and progress assessment. In palliative care, clinical and academic approaches need greater integration. Multiprofessional learning is essential. To allow individuals to undertake higher research degree programmes, fellowships or specific funding are needed.

  14. Towards automatic coupling corrections with DOROS BPMs (MD750)

    CERN Document Server

    Persson, Tobias Hakan Bjorn; Langner, Andy Sven; Lefevre, Thibaut; Maclean, Ewen Hamish; Malina, Lukas; Olexa, Jakub; Skowronski, Piotr Krzysztof; Garcia-Tabares Valdivieso, Ana; Coello De Portugal - Martinez Vazquez, Jaime Maria; Tomas Garcia, Rogelio; CERN. Geneva. ATS Department

    2015-01-01

    BPMs close to IP1 and IP5 have been equipped with the new DOROS (Diode ORbit OScillation) system which provides precise orbit and turn-by-turn data [1]. In this MD-note we report on the rst measurements with the DOROS system to measure the transverse coupling. Furthermore, we compare the results and the performance of the system to the normal BPMs.

  15. MD 349: Impedance Localization with AC-dipole

    CERN Document Server

    Biancacci, Nicolo; Metral, Elias; Salvant, Benoit; Papotti, Giulia; Persson, Tobias Hakan Bjorn; Tomas Garcia, Rogelio; CERN. Geneva. ATS Department

    2016-01-01

    The purpose of this MD is to measure the distribution of the transverse impedance of the LHC by observing the phase advance variation with intensity between the machine BPMs. Four injected bunches with different intensities are excited with an AC dipole and the turn by turn data is acquired from the BPM system. Through post-processing analysis the phase variation along the machine is depicted and, from this information, first conclusions of the impedance distribution can be drawn.

  16. MD 1691: Active halo control using tune ripple at injection

    CERN Document Server

    Garcia Morales, Hector; Bruce, Roderik; Redaelli, Stefano; Fitterer, Miriam; Fiascaris, Maria; Nisbet, David; Thiesen, Hugues; Valentino, Gianluca; Xu, Chen; CERN. Geneva. ATS Department

    2017-01-01

    In this MD we performed halo excitation through tune ripple. This consists in an excitation that introduces new resonance sidebands around the existing resonance lines. In presence of sufficient detuning with amplitude, these sidebands can in principle affect only the dynamics of the halo particles at large amplitudes. Tune ripple was induced through a current modulation of the warm trim quadrupoles in IR7. This is the first time this method is experimentally tested at the LHC.

  17. Review of 40-year MD theses in Medical Oncology

    International Nuclear Information System (INIS)

    Zeeneldin, A.; Diyaa, A.; Elgammal, M.; Buhoush, W.; Manar Moneer, M.

    2014-01-01

    Background and objective: It is almost 40 years since the foundation of the Medical Oncology (MO) Department. We aimed to appraise the clinical research to fulfill the Medical Doctorate (MD) degree in MO at the National Cancer Institute, Cairo University (NCI, CU). Methods: This review included 62 MD theses containing 66 studies. They were reviewed regarding aims, type of study, clinical trial phase, design and methodology, statistical tests, results, limitations, consent and IRB approval. Theses were grouped into 3 periods: 1970-1989, 1990-1999 and 2000- 2008. Results: Almost 76% of the studies were interventional and 24% were observational. Informed consent and Institutional Review Board approval were mentioned in 18 and 2 studies, respectively. While all studies mentioned the aims, none, clearly mentioned the research question. Outcomes were mainly efficacy followed by safety. Study design was inadequately considered, especially in 70’s–80’s period (p = 0.038). Median sample size and study duration were almost stable through the three periods (p = 0.441, 0.354, respectively). Most of the studies used both descriptive and analytical statistical methods. In a descending order, researched cancers were lymphoma, breast, leukemia, liver, urinary bladder, lung and colorectal. The commonest stages researched were IV and III. The number of studies focused on assessing biomarkers, biomarkers plus drugs/procedures, drugs and procedures are 20, 20, 16 and 6, respectively. Conclusion: With time, research within MD theses in MO increased quantitatively and qualitatively. Improvements were noticeable in documentation of study design.

  18. MD Anderson's Population Health Approaches to Cancer Prevention.

    Science.gov (United States)

    Foxhall, Lewis; Moreno, Mark; Hawk, Ernest

    2018-02-01

    Texas's size and unique population demographics present challenges to addressing the state's cancer burden. The University of Texas MD Anderson Cancer Center is one of 69 National Cancer Institute-designated cancer centers across the United States. While these centers traditionally have focused on research, education and training, and providing research-driven patient care, they are in a unique position to collaboratively advance population health through cancer control. Unlike the traditional academic model of a three-legged stool representing research, education, and patient care, MD Anderson's mission includes a fourth leg that incorporates population health approaches. MD Anderson has leveraged state- and national-level data and freely available resources to develop population-health priorities and a set of evidence-based actions across policy, public and professional education, and community-based clinical service domains to address these priorities. Population health approaches complement dissemination and implementation research and treatment, and will be increasingly needed to address the growing cancer burden in Texas and the nation.

  19. MD2036: UFO Dynamics Studies and UFO Fast Detection

    CERN Document Server

    Belanger, Philippe; Valette, Matthieu; Lindstrom, Bjorn Hans Filip; Grob, Laura Katharina; Schmidt, Rudiger; Wollmann, Daniel

    2017-01-01

    UFOs are one of the remaining unknown related to LHC operation. Therefore, improving the understanding of UFO dynamics and validating the developed models against direct beam measurements is of fundamental importance in view of LHC operation at 7 TeV and with HL-LHC beam intensities. If not understood, UFOs could also be a showstopper for future machines such as FCC. This MD demonstrates new methods to study the dynamic behaviour of a calibrated UFO, simulated by the interaction of wire scanners with the beam. The events created during the MD were monitored using diamond BLMs in IR7, providing bunch-by-bunch resolution measurements. The analysis presented herein shows that blown-up bunches can be used to identify the plane of movement of UFOs, that bunch profiles and bunch sizes can be measured with dBLMs with good precision, that simulation of expected losses are in good agreement with measurements for oscillating bunches and that the space resolution of the acquisition system used during the MD is about 10 ...

  20. The hydration enthalpies of Md3+ and Lr3+

    International Nuclear Information System (INIS)

    Bruechle, W.; Schaedel, M.; Scherer, U.W.; Kratz, J.V.

    1987-10-01

    Lawrencium (3-min 260 Lr) and lighter actinides were produced in the bombardement of a 249 Bk target with 18 O ions and loaded onto a cation exchange column in 0.05 M α-hydroxy-isobutyrate solution at pH = 4.85 together with the radioactive lanthanide tracers 166 Ho, 171 Er, and 171 Tm. In elutions with 0.12 M α-hydroxy-isobutyrate solution (pH = 4.85) trivalent Lr was eluted exactly together with the Er tracer and Md close to Ho. Lr elutes much later than expected based on the known elution positions of the lighter actinides and the expected analogy to the elution positions of the homologous lanthanides. From the measured elution positions, ionic radii were calculated for Lr 3+ and Md 3+ . Semiempirical models allow the calculation of the heat of hydration from the ionic radii, resulting in ΔH hyd ≅ - 3654 kJ/mol for Md 3+ and ΔH hyd ≅ - 3689 kJ/mol for Lr 3+ . (orig.)

  1. Multi-Device to Multi-Device (MD2MD Content-Centric Networking Based on Multi-RAT Device

    Directory of Open Access Journals (Sweden)

    Cheolhoon Kim

    2017-11-01

    Full Text Available This paper proposes a method whereby a device can transmit and receive information using a beacon, and also describes application scenarios for the proposed method. In a multi-device to multi-device (MD2MD content-centric networking (CCN environment, the main issue involves searching for and connecting to nearby devices. However, if a device can’t find another device that satisfies its requirements, the connection is delayed due to the repetition of processes. It is possible to rapidly connect to a device without repetition through the selection of the optimal device using the proposed method. Consequently, the proposed method and scenarios are advantageous in that they enable efficient content identification and delivery in a content-centric Internet of Things (IoT environment, in which multiple mobile devices coexist.

  2. Sammenlimning af begge øjne skal ikke behandles konservativt

    DEFF Research Database (Denmark)

    Øgard, Carsten; Kjaerbo, Hadi; Sørensen, Torben Lykke

    2010-01-01

    We describe a case of a 4-year-old boy who accidentally had both eyes glued together. The eyelashes were cut and the boy's eyelids were separated in general anaesthesia. When both eyes are glued together, we do not recommend expectancy, especially not in paediatric cases. For psychological reason......, the lids should be separated surgically. Furthermore, we suggest that similarities between ophthalmic bottles and superglue bottles are avoided so that future incidences may be avoided....

  3. Rhodotorula taiwanensis MD1149 produces hypoacetylated PEFA compounds with increased surface activity compared to Rhodotorula babjevae MD1169

    Science.gov (United States)

    Rubinfeld, Bonnee; Leif, Roald; Mulcahy, Heather; Dugan, Lawrence; Souza, Brian

    2018-01-01

    Biosurfactants have several desirable characteristics in the industrial sector: detergency, antimicrobial effects, skin hydration, and emulsibility. Several yeast glycolipids are currently being utilized in these capacities: sophorolipids, ustilagic acid, and mannosylerythritol lipids (MELs). An emerging class of glycolipids, termed polyol esters of fatty acids (PEFA), have recently been reported for Rhodotorula babjevae, a basidiomycetous yeast species that secretes hyperacetylated congeners of PEFA (typically with 3–6 acetylation modifications). While screening Rhodotorula species for surfactant production, we identified a new environmental isolate identified as Rhodotorula taiwanensis MD1149 that dropped the surface tension of the liquid medium, indicating that it produced a potent biosurfactant. Acid depolymerization of the purified biosurfactants, followed by gas chromatography-mass spectrometry (GC-MS) analysis revealed that the biosurfactants were composed of PEFA compounds composed mainly of mannitol and arabitol esters of 3-hydroxy fatty acid, 3-methoxy fatty acid, and fatty acids with a single double bond; chain lengths were mainly C16 and C18. Liquid chromatography-mass spectrometry (LC-MS) confirmed the predicted accurate mass of these compounds. Interestingly, PEFA compounds produced by Rhodotorula taiwanensis MD1149 were more surface active due to their hypoacetylation profile (0–4 acetylation modifications) compared to Rhodotorula babjevae MD1169. These disparate surface active properties, based on acetylation, change the hydrophilic-lipophilic balance (HLB) of these compounds, and their potential utility within industrial applications. PMID:29293588

  4. Rhodotorula taiwanensis MD1149 produces hypoacetylated PEFA compounds with increased surface activity compared to Rhodotorula babjevae MD1169.

    Science.gov (United States)

    Lyman, Mathew; Rubinfeld, Bonnee; Leif, Roald; Mulcahy, Heather; Dugan, Lawrence; Souza, Brian

    2018-01-01

    Biosurfactants have several desirable characteristics in the industrial sector: detergency, antimicrobial effects, skin hydration, and emulsibility. Several yeast glycolipids are currently being utilized in these capacities: sophorolipids, ustilagic acid, and mannosylerythritol lipids (MELs). An emerging class of glycolipids, termed polyol esters of fatty acids (PEFA), have recently been reported for Rhodotorula babjevae, a basidiomycetous yeast species that secretes hyperacetylated congeners of PEFA (typically with 3-6 acetylation modifications). While screening Rhodotorula species for surfactant production, we identified a new environmental isolate identified as Rhodotorula taiwanensis MD1149 that dropped the surface tension of the liquid medium, indicating that it produced a potent biosurfactant. Acid depolymerization of the purified biosurfactants, followed by gas chromatography-mass spectrometry (GC-MS) analysis revealed that the biosurfactants were composed of PEFA compounds composed mainly of mannitol and arabitol esters of 3-hydroxy fatty acid, 3-methoxy fatty acid, and fatty acids with a single double bond; chain lengths were mainly C16 and C18. Liquid chromatography-mass spectrometry (LC-MS) confirmed the predicted accurate mass of these compounds. Interestingly, PEFA compounds produced by Rhodotorula taiwanensis MD1149 were more surface active due to their hypoacetylation profile (0-4 acetylation modifications) compared to Rhodotorula babjevae MD1169. These disparate surface active properties, based on acetylation, change the hydrophilic-lipophilic balance (HLB) of these compounds, and their potential utility within industrial applications.

  5. MdMYB9 and MdMYB11 are involved in the regulation of the JA-induced biosynthesis of anthocyanin and proanthocyanidin in apples.

    Science.gov (United States)

    An, Xiu-Hong; Tian, Yi; Chen, Ke-Qin; Liu, Xiao-Juan; Liu, Dan-Dan; Xie, Xing-Bin; Cheng, Cun-Gang; Cong, Pei-Hua; Hao, Yu-Jin

    2015-04-01

    Anthocyanin and proanthocyanidin (PA) are important secondary metabolites and beneficial to human health. Their biosynthesis is induced by jasmonate (JA) treatment and regulated by MYB transcription factors (TFs). However, which and how MYB TFs regulate this process is largely unknown in apple. In this study, MdMYB9 and MdMYB11 which were induced by methyl jasmonate (MeJA) were functionally characterized. Overexpression of MdMYB9 or MdMYB11 promoted not only anthocyanin but also PA accumulation in apple calluses, and the accumulation was further enhanced by MeJA. Subsequently, yeast two-hybrid, pull-down and bimolecular fluorescence complementation assays showed that both MYB proteins interact with MdbHLH3. Moreover, Jasmonate ZIM-domain (MdJAZ) proteins interact with MdbHLH3. Furthermore, chromatin immunoprecipitation-quantitative PCR and yeast one-hybrid assays demonstrated that both MdMYB9 and MdMYB11 bind to the promoters of ANS, ANR and LAR, whereas MdbHLH3 is recruited to the promoters of MdMYB9 and MdMYB11 and regulates their transcription. In addition, transient expression assays indicated that overexpression of MdJAZ2 inhibits the recruitment of MdbHLH3 to the promoters of MdMYB9 and MdMYB11. Our findings provide new insight into the mechanism of how MeJA regulates anthocyanin and PA accumulation in apple. © The Author 2014. Published by Oxford University Press on behalf of Japanese Society of Plant Physiologists. All rights reserved. For permissions, please email: journals.permissions@oup.com.

  6. 76 FR 5686 - Drawbridge Operation Regulation; Pocomoke River, Pocomoke City, MD

    Science.gov (United States)

    2011-02-02

    ... Operation Regulation; Pocomoke River, Pocomoke City, MD AGENCY: Coast Guard, DHS. ACTION: Notice of... River, mile 15.6, at Pocomoke City, MD. The deviation restricts the operation of the draw span to.... The Route 675 Bridge across Pocomoke River, mile 15.6 at Pocomoke City MD, has a vertical clearance in...

  7. 75 FR 49992 - Peter W.S. Grigg, M.D.; Revocation of Registration

    Science.gov (United States)

    2010-08-16

    ... DEPARTMENT OF JUSTICE Drug Enforcement Administration Peter W.S. Grigg, M.D.; Revocation of... Order to Show Cause and Immediate Suspension of Registration to Peter W.S. Grigg, M.D. (Respondent), of... Registration, BG2107856, issued to Peter W.S. Grigg, M.D., be, and it hereby is, revoked. This Order is...

  8. 77 FR 7182 - Scott W. Houghton, M.D.; Decision and Order

    Science.gov (United States)

    2012-02-10

    ... DEPARTMENT OF JUSTICE Drug Enforcement Administration [Docket No. 12-09] Scott W. Houghton, M.D... CFR 0.100(b), I order that DEA Certificate of Registration BH8796077, issued to Scott W. Houghton, M.D., be, and it hereby is, revoked. I further order that any pending application of Scott W. Houghton, M.D...

  9. 76 FR 48898 - Robert Leigh Kale, M.D., Decision and Order

    Science.gov (United States)

    2011-08-09

    ... DEPARTMENT OF JUSTICE Drug Enforcement Administration Robert Leigh Kale, M.D., Decision and Order... Enforcement Administration, issued an Order to Show Cause to Robert Leigh Kale, M.D. (Registrant), of Fort... Certificate of Registration, BK9514375, issued to Robert Leigh Kale, M.D., be, and it hereby is, revoked. I...

  10. 76 FR 20032 - Thomas E. Mitchell, M.D.; Dismissal of Proceeding

    Science.gov (United States)

    2011-04-11

    ... DEPARTMENT OF JUSTICE Drug Enforcement Administration [Docket No. 10-7] Thomas E. Mitchell, M.D... Control, Drug Enforcement Administration, issued an Order to Show Cause to Thomas E. Mitchell, M.D....100(b) and 0.104, I hereby order that the Order to Show Cause issued to Thomas E. Mitchell, M.D., be...

  11. StandsSIM-MD: a Management Driven forest SIMulator

    Energy Technology Data Exchange (ETDEWEB)

    Barreiro, S.; Rua, J.; Tomé, M.

    2016-07-01

    Aim of the study. The existing stand level forest simulators available in Portugal were not developed with the aim of including up-to-date model versions and were limited in terms of accounting for forest management. The simulators’ platform, sIMfLOR was recently created to implement different growth models with a common philosophy. The objective was developing one easily-updatable, user-friendly, forest management and climate change sensitive simulator capable of projecting growth for the main tree species in Portugal. Area of the study: Portugal. Material and methods: The new simulator was programmed in a modular form consisting of several modules. The growth module integrates different forest growth and yield models (empirical and process-based) for the main wood production tree species in Portugal (eucalypt, umbrella and maritime pines); whereas the management module drives the growth projections along the planning horizon according to a range of forest management approaches and climate (at present only available for eucalypt). Main results: The main result is the StandsSIM-MD Management Driven simulator that overcomes the limitations of the existing stand level simulators. It is a step forward when compared to the models currently available in the sIMfLOR platform covering more tree species, stand structures and stand compositions. It is focused on end-users and it is based on similar concepts regarding the generation of required inputs and generated outputs. Research highlights: Forest Management Driven simulations approach. Multiple Prescriptions-Per-Stand functionality. StandsSIM-MD can be used to support landowners decisions on stand forest management. StandsSIM-MD simulations at regional level can be combined with optimization routines. (Author)

  12. Review of 40-year MD theses in medical oncology.

    Science.gov (United States)

    Zeeneldin, Ahmed; Diyaa, Amira; Moneer, Manar; Elgammal, Mosaad; Buhoush, Wafa

    2014-09-01

    It is almost 40 years since the foundation of the Medical Oncology (MO) Department. We aimed to appraise the clinical research to fulfill the Medical Doctorate (MD) degree in MO at the National Cancer Institute, Cairo University (NCI, CU). This review included 62 MD theses containing 66 studies. They were reviewed regarding aims, type of study, clinical trial phase, design and methodology, statistical tests, results, limitations, consent and IRB approval. Theses were grouped into 3 periods: 1970-1989, 1990-1999 and 2000-2008. Almost 76% of the studies were interventional and 24% were observational. Informed consent and Institutional Review Board approval were mentioned in 18 and 2 studies, respectively. While all studies mentioned the aims, none, clearly mentioned the research question. Outcomes were mainly efficacy followed by safety. Study design was inadequately considered, especially in 70's-80's period (p=0.038). Median sample size and study duration were almost stable through the three periods (p=0.441, 0.354, respectively). Most of the studies used both descriptive and analytical statistical methods. In a descending order, researched cancers were lymphoma, breast, leukemia, liver, urinary bladder, lung and colorectal. The commonest stages researched were IV and III. The number of studies focused on assessing biomarkers, biomarkers plus drugs/procedures, drugs and procedures are 20, 20, 16 and 6, respectively. With time, research within MD theses in MO increased quantitatively and qualitatively. Improvements were noticeable in documentation of study design. Copyright © 2014. Production and hosting by Elsevier B.V.

  13. Coupling of relative intensity noise and pathlength noise to the length measurement in the optical metrology system of LISA Pathfinder

    Science.gov (United States)

    Wittchen, Andreas; the LPF Collaboration

    2017-05-01

    LISA Pathfinder is a technology demonstration mission for the space-based gravitational wave observatory, LISA. It demonstrated that the performance requirements for the interferometric measurement of two test masses in free fall can be met. An important part of the data analysis is to identify the limiting noise sources. [1] This measurement is performed with heterodyne interferometry. The performance of this optical metrology system (OMS) at high frequencies is limited by sensing noise. One such noise source is Relative Intensity Noise (RIN). RIN is a property of the laser, and the photodiode current generated by the interferometer signal contains frequency dependant RIN. From this electric signal the phasemeter calculates the phase change and laser power, and the coupling of RIN into the measurement signal depends on the noise frequency. RIN at DC, at the heterodyne frequency and at two times the heterodyne frequency couples into the phase. Another important noise at high frequencies is path length noise. To reduce the impact this noise is suppressed with a control loop. Path length noise not suppressed will couple directly into the length measurement. The subtraction techniques of both noise sources depend on the phase difference between the reference signal and the measurement signal, and thus on the test mass position. During normal operations we position the test mass at the interferometric zero, which is optimal for noise subtraction purposes. This paper will show results from an in-flight experiment where the test mass position was changed to make the position dependant noise visible.

  14. A molecular dynamics (MD simulation on tire-aggregate friction

    Directory of Open Access Journals (Sweden)

    Fengyan Sun

    2017-07-01

    Full Text Available The friction between tire and road surface is fundamentally depending on the molecular forces. In this paper, the nanoscale 3D contact model is employed to investigate the tire-aggregate friction mechanism. The tire and aggregate micro-structure are both constructed to evaluate the microscopic performance of tire-aggregate friction influence. Simulation results show for a high velocity, the energy dissipation of sliding on crystal structure is small, which results in a small friction coefficient; temperature will have influences on the friction coefficient, and with the increasing of velocity, the effect will gradually reduce. Keywords: Tire, Aggregate, Friction coefficient, Microscopic mechanism, MD simulation

  15. StandsSIM-MD: a Management Driven forest SIMulator

    Directory of Open Access Journals (Sweden)

    Susana Barreiro

    2016-07-01

    Full Text Available Aim of the study: The existing stand level forest simulators available in Portugal were not developed with the aim of including up-to-date model versions and were limited in terms of accounting for forest management. The simulators’ platform, sIMfLOR was recently created to implement different growth models with a common philosophy. The objective was developing one easily-updatable, user-friendly, forest management and climate change sensitive simulator capable of projecting growth for the main tree species in Portugal. Area of the study: Portugal. Material and methods: The new simulator was programmed in a modular form consisting of several modules. The growth module integrates different forest growth and yield models (empirical and process-based for the main wood production tree species in Portugal (eucalypt, umbrella and maritime pines; whereas the management module drives the growth projections along the planning horizon according to a range of forest management approaches and climate (at present only available for eucalypt. Main results: The main result is the StandsSIM-MD Management Driven simulator that overcomes the limitations of the existing stand level simulators. It is a step forward when compared to the models currently available in the sIMfLOR platform covering more tree species, stand structures and stand compositions. It is focused on end-users and it is based on similar concepts regarding the generation of required inputs and generated outputs. Research highlights: -          Forest Management Driven simulations approach -          Multiple Prescriptions-Per-Stand functionality -          StandsSIM-MD can be used to support landowners decisions on stand forest management -          StandsSIM-MD simulations at regional level can be combined with optimization routines Keywords: Forest simulator, Forest Management Approaches; StandsSIM-MD; forest management.

  16. Radioprotective and radiotherapeutic properties of biotechnological agent MD2

    International Nuclear Information System (INIS)

    Sobol, C.V.; Komar, V.E.; Sobol, Y.T.

    1996-01-01

    In recent years as the result of nuclear testing and accidents at nuclear power plants such as Chernobyl, etc. radiation exposure has become a major issue in various parts of the world. Experience of recent nuclear accidents has shown there is no effective treatment for patients expose to doses of radiation that result in fatal hematopoietic failure and /or secondary infections. Therefore, agents that are effective when administered after irradiation, are of great interest. In this study, the possibility of using biotechnological agent MD2 after lethal total body irradiation (TBI) and radiotherapy has been demonstrated. In addition, the considerable radioprotection without toxic effect can be obtained. (author)

  17. Développement et exploitation d'un simulateur électro-optique pour le futur détecteur spatial à ondes gravitationnelles eLISA

    OpenAIRE

    Gruning , Pierre

    2015-01-01

    Gravitational waves will offer a new window to the universe. Their detection by ground based detectors should arrive soon and the future space based interferometer eLISA will allow to do gravitational wave astronomy in order to get unique informations on their sources wether black holes, neutron stars, the Big Bang etc. The effect of a gravitational wave is an extremely weak variation of distance, it will require a very performant detector. That’s why eLISA should reach picometer precision wi...

  18. Full-Scale Crash Test of an MD-500 Helicopter

    Science.gov (United States)

    Littell, Justin

    2011-01-01

    A full-scale crash test was successfully conducted in March 2010 of an MD-500 helicopter at NASA Langley Research Center s Landing and Impact Research Facility. The reasons for conducting this test were threefold: 1 To generate data to be used with finite element computer modeling efforts, 2 To study the crashworthiness features typically associated with a small representative helicopter, and 3 To compare aircraft response to data collected from a previously conducted MD-500 crash test, which included an externally deployable energy absorbing (DEA) concept. Instrumentation on the airframe included accelerometers on various structural components of the airframe; and strain gages on keel beams, skid gear and portions of the skin. Three Anthropomorphic Test Devices and a specialized Human Surrogate Torso Model were also onboard to collect occupant loads for evaluation with common injury risk criteria. This paper presents background and results from this crash test conducted without the DEA concept. These results showed accelerations of approximately 30 to 50 g on the airframe at various locations, little energy attenuation through the airframe, and moderate to high probability of occupant injury for a variety of injury criteria.

  19. MD1878: Operation with primary collimators at tighter settings

    CERN Document Server

    AUTHOR|(CDS)2078850; Amorim, David; Biancacci, Nicolo; Bruce, Roderik; Buffat, Xavier; Carver, Lee Robert; Fiascaris, Maria; Mereghetti, Alessio; Redaelli, Stefano; Rossi, Roberto; Salvachua Ferrando, Belen Maria; Soderen, Martin; Trad, Georges; CERN. Geneva. ATS Department

    2017-01-01

    Primary (TCP) collimators of the betatron cleaning insertion determine the betatron cut of the LHC beam. During the 2016 they were set at 5.5 nominal beam sigmas at 6.5 TeV (i.e. by using a normalized emittance ε* = 3:5 μm is used). Reducing their settings is a possible way to push the ß* at the LHC, which depends on the collimation hierarchy. This study aims at understanding possible limitations of operating the LHC with tighter settings of the primary collimators. This is a crucial input to the choice of operational configuration in terms of ß* at the LHC as well as at the HL-LHC. This study follows a successful MD done in block 3 to understand limitations from TCP impedance [1]. The outcome of this MD can also have an impact for the design of the FCC collimation system, which is currently based on the present TCP gaps. Studies of beam stability as a function of octupole current, transverse feedback gain (ADT) and transverse separation at the IPs were also carried out.

  20. [Professor Frantisek Por MD and Professor Robert Klopstock MD, students at Budapest and Prague Faculties of Medicine].

    Science.gov (United States)

    Mydlík, M; Derzsiová, K

    2010-11-01

    Professor Frantisek Por MD and Professor Robert Klopstock MD were contemporaries, both born in 1899, one in Zvolen, the other in Dombovar, at the time of Austro-Hungarian Monarchy. Prof. Por attended the Faculty of Medicine in Budapest from 1918 to 1920, and Prof. Klopstock studied at the same place between 1917 and 1919. From 1920 until graduation on 6th February 1926, Prof. Por continued his studies at the German Faculty of Medicine, Charles University in Prague. Prof. Klopstock had to interrupt his studies in Budapest due to pulmonary tuberculosis; he received treatment at Tatranske Matliare where he befriended Franz Kafka. Later, upon Kafka's encouragement, he changed institutions and continued his studies at the German Faculty of Medicine, Charles University in Prague, where he graduated the first great go. It is very likely that, during their studies in Budapest and Prague, both professors met repeatedly, even though their life paths later separated. Following his graduation, Prof. Por practiced as an internist in Prague, later in Slovakia, and from 1945 in Kosice. In 1961, he was awarded the title of university professor of internal medicine at the Faculty of Medicine, Pavol Jozef Safarik University in Kosice, where he practiced until his death in 1980. Prof. Klopstock continued his studies in Kiel and Berlin. After his graduation in 1933, he practiced in Berlin as a surgeon and in 1938 left for USA. In 1962, he was awarded the title of university professor of pulmonary surgery in NewYork, where he died in 1972.

  1. Transport and characterization of ambient biological aerosol near Laurel, MD

    Science.gov (United States)

    Santarpia, J. L.; Cunningham, D.; Gilberry, J.; Kim, S.; Smith, E. E.; Ratnesar-Shumate, S.; Quizon, J.

    2010-09-01

    Bacterial aerosol have been observed and studied in the ambient environment since the mid nineteenth century. These studies have sought to provide a better understanding of the diversity, variability and factors that control the biological aerosol population. In this study, we show comparisons between diversity of culturable bacteria and fungi, using culture and clinical biochemical tests, and 16S rRNA diversity using Affymetrix PhyloChips. Comparing the culturable fraction and surveying the total 16S rRNA of each sample provides a comprehensive look at the bacterial population studied and allows comparison with previous studies. Thirty-six hour back-trajectories of the air parcels sampled, over the two day period beginning 4 November 2008, provide information on the sources of aerosol sampled on the campus of Johns Hopkins University Applied Physics Laboratory in Laurel, MD. This study indicates that back-trajectory modeling of air parcels may provide insights into the observed diversity of biological aerosol.

  2. A workshop on leadership for MD/PhD students

    Directory of Open Access Journals (Sweden)

    Mark D. Cannon

    2011-08-01

    Full Text Available Success in academic medicine requires scientific and clinical aptitude and the ability to lead a team effectively. Although combined MD/PhD training programs invest considerably in the former, they often do not provide structured educational opportunities in leadership, especially as applied to investigative medicine. To fill a critical knowledge gap in physician-scientist training, the Vanderbilt Medical Scientist Training Program (MSTP developed a biennial two-day workshop in investigative leadership. MSTP students worked in partnership with content experts to develop a case-based curriculum and deliver the material. In its initial three offerings in 2006, 2008, and 2010, the workshop was judged by MSTP student attendees to be highly effective. The Vanderbilt MSTP Leadership Workshop offers a blueprint for collaborative student-faculty interactions in curriculum design and a new educational modality for physician-scientist training.

  3. Jules Stein, MD: Ophthalmologist, Entertainment Magnate, and Advocate for Vision.

    Science.gov (United States)

    Straatsma, Bradley R; Weeks, David F

    2016-04-01

    To report the lifetime activities and accomplishments of Jules Stein, MD. Retrospective review. Assessment of published and unpublished biographical material. Jules Stein combined his love of music and medicine with organizational skills to achieve successive careers as a musician, an ophthalmologist, an entertainment magnate, and an advocate for vision. To preserve vision, he founded Research to Prevent Blindness, founded the Jules Stein Eye Institute at the University of California, Los Angeles, and led a multiyear campaign to establish the National Eye Institute. With successive careers and extraordinary achievements, Jules Stein created an enduring legacy of benefits to ophthalmology, vision research, and the prevention of blindness. Copyright © 2016 American Academy of Ophthalmology. Published by Elsevier Inc. All rights reserved.

  4. Medicinal Cannabis in California: An Interview with Igor Grant, MD.

    Science.gov (United States)

    Piomelli, Daniele; Grant, Igor

    2016-01-01

    Dr. Igor Grant, MD, is distinguished professor and chair of psychiatry and director of the HIV Neurobehavioral Research Program and the Center for Medicinal Cannabis Research at the University of California, San Diego. Dr. Grant is a neuropsychiatrist who graduated from the University of British Columbia School of Medicine (1966), and received specialty training in psychiatry at the University of Pennsylvania (1967-1971), and additional training in neurology at the Institute of Neurology (1980-1981), London, U.K. Dr. Grant's academic interests focus on the effects of various diseases on brain and behavior, with an emphasis on translational studies in HIV, and drugs of abuse. He has contributed to ∼700 scholarly publications and is principal investigator of several NIH studies, including an NIDA P50 (Translational Methamphetamine AIDS Research Center-TMARC), and is codirector of the HIV Neurobehavioral Research Center (HNRC).

  5. LHC β*-reach MD: aperture measurements at small β*

    CERN Document Server

    Fuster Martinez, Nuria; Redaelli, Stefano; CERN. Geneva. ATS Department

    2017-01-01

    During this MD, performed on the 25th of July 2017, we measured the LHC aperture at top energy for β*=30 cm using the Transverse Damper (ADT) blow-up method. These measurements are part of the standard commissioning of an optics and have been performed in order to provide early on inputs for a possible change of β* later in 2017, as envisaged previously to fully profit from the additional margins introduced by the rematched phase advance between dump kickers and the TCTs (Target Collimator Tertiary). In addition to the aperture measurements, two other commissioning important tests were performed: loss maps for the nominal TCTs settings and an asynchronous dump validation with tighter TCT gaps.

  6. Luminosity Anti-leveling with Crossing Angle (MD 1669)

    CERN Document Server

    Gorzawski, Arkadiusz; Ponce, Laurette; Salvachua Ferrando, Belen Maria; Wenninger, Jorg; CERN. Geneva. ATS Department

    2016-01-01

    A significant fraction of the LHC luminosity ($\\sim$30\\% in 2016) is lost due to the presence (and necessity) of the crossing angles at the IPs. At the LHC the crossing angle is typically set to a value that provides sufficient separation of the beams at the start of fills for the peak bunch intensities. As the bunch intensity decays during a fill, it is possible to reduce the crossing angle and recover some luminosity. A smooth crossing angle reduction procedure must be developed to take advantage of this option during stable beam operation. During this MD a smooth procedure for luminosity leveling with crossing angle was tested. It was demonstrated that the orbit was well controlled, beam losses were low and the offset leveled experiments ALICE and LHCb were not affected by crossing angle leveling in ATLAS and CMS.

  7. Report from LHC MD 2158: IR-nonlinear studies

    CERN Document Server

    Maclean, Ewen Hamish; Cruz Alaniz, Emilia; Dalena, Barbara; Dilly, Joschua Werner; Fol, Elena; Giovannozzi, Massimo; Hofer, Michael; Malina, Lukas; Persson, Tobias Hakan Bjorn; Coello De Portugal - Martinez Vazquez, Jaime Maria; Skowronski, Piotr Krzysztof; Solfaroli Camillocci, Matteo; Tomas Garcia, Rogelio; Garcia-Tabares Valdivieso, Ana; Wegscheider, Andreas; CERN. Geneva. ATS Department

    2018-01-01

    For the first time the LHC is running for luminosity-production with local corrections for nonlinear errors in the ATLAS and CMS insertions. While a major step forward in LHC optics commissioning strategy (and one which has yielded clear operational benefits) considerable challenges remain to be overcome, both in regard to the optimization of LHC optics and in order to ensure successful commissioning of the High-Luminosity LHC. MD 2158 sought to follow up several aspects of the 2017 nonlinear optics commissioning which are not yet understood, and by enhancing sextupole and dodecapole sources in the ATLAS and CMS insertions explore the prospects for linear and nonlinear optics commissioning in the HL-LHC.

  8. MD 979: Beta-beating measurements on colliding beams

    CERN Document Server

    Goncalves Jorge, Patrik; Pieloni, Tatiana; Buffat, Xavier; Carlier, Felix Simon; Coello De Portugal - Martinez Vazquez, Jaime Maria; Fol, Elena; Langner, Andy Sven; Medina Medrano, Luis Eduardo; Olexa, Jakub; Tomas Garcia, Rogelio; Valuch, Daniel; Wegscheider, Andreas; CERN. Geneva. ATS Department

    2017-01-01

    The HL-LHC high brightness beams will give a large β-beating due to the head-on and long-range interactions since a beam-beam parameter of 0.01 per Interaction Point (IP) is expected. The β-heating induced by two head-on collision reaches 15%. A third IP, i.e. IP8, could bring the β-heating up to 24%. The aim of the Machine Development (MD) study was to test optics measurements with AC dipole and ADT on colliding beams at injection and to implement a correction of the β-heating due to to head-on collision in the two experiments IP1&5. Int his note, we summarize the first results of this test performed in the LHC.

  9. Leonard F. Peltier, MD, PhD, 1920-2003.

    Science.gov (United States)

    Reckling, Frederick W; Lo Vecchio, Janolyn G; Reckling, JoAnn B

    2004-05-01

    Leonard F. Peltier, MD, PhD, was an orthopaedic surgeon, academician, administrator, laboratory investigator, historian, and mentor. His career spanned nearly six decades, beginning with graduate education at the University of Minnesota (UM) under the auspices of Owen H. Wangensteen, MD, PhD. In addition to obtaining a PhD in physiology in the UM Graduate School, he completed general and orthopaedic surgery residencies and attained board certification in each specialty. He served in the US Army Occupation Force Medical Corps in Germany just after World War II. In 1957, at 37 years old, he assumed the chairmanship of the orthopaedic training program at the University of Kansas. In 1971, he couldn't resist the opportunity to become one of the founding members of the "start-up" University of Arizona College of Medicine, accepting an appointment as chair of the new orthopaedic training program, where he remained until his retirement in 1990. He took clinical problems to the laboratory, and made important scientific contributions, particularly in the area of fat embolism and in using calcium sulfate (plaster of Paris) to fill bone defects. He served on governing boards of national professional organizations and presided over the American Association for the Surgery of Trauma from 1980-1981. Throughout his career, he was fascinated by, and published extensively in, the history of medicine arena. Known fondly as "the professor" to many of his residents and colleagues, he had a pragmatic, honest, upbeat, and often humorous approach to life's challenges, valuing personal integrity above other virtues. He explored various eclectic interests far beyond his professional contributions while maintaining his family as a central priority. With his exemplary productivity and interests in the surgical and laboratory sciences, history of medicine, appreciation of fine arts, and perceptive and effective interactions with family, friends, patients, and colleagues, the memory of Leonard

  10. Actuation crosstalk in free-falling systems: Torsion pendulum results for the engineering model of the LISA pathfinder gravitational reference sensor

    Science.gov (United States)

    Bassan, M.; Cavalleri, A.; De Laurentis, M.; De Marchi, F.; De Rosa, R.; Di Fiore, L.; Dolesi, R.; Finetti, N.; Garufi, F.; Grado, A.; Hueller, M.; Marconi, L.; Milano, L.; Minenkov, Y.; Pucacco, G.; Stanga, R.; Vetrugno, D.; Visco, M.; Vitale, S.; Weber, W. J.

    2018-01-01

    In this paper we report on measurements on actuation crosstalk, relevant to the gravitational reference sensors for LISA Pathfinder and LISA. In these sensors, a Test Mass (TM) falls freely within a system of electrodes used for readout and control. These measurements were carried out on ground with a double torsion pendulum that allowed us to estimate both the torque injected into the sensor when a control force is applied and, conversely, the force leaking into the translational degree of freedom due to the applied torque.The values measured on our apparatus (the engineering model of the LISA Pathfinder sensor) agree to within 0.2% (over a maximum measured crosstalk of 1%) with predictions of a mathematical model when measuring force to torque crosstalk, while it is somewhat larger than expected (up to 3.5%) when measuring torque to force crosstalk. However, the values in the relevant range, i.e. when the TM is well centered ( ± 10 μm) in the sensor, remain smaller than 0.2%, satisfying the LISA Pathfinder requirements.

  11. Complicating Culture and Difference: Situating Asian American Youth Identities in Lisa Yee's "Millicent Min," "Girl Genius" and "Stanford Wong Flunks Big-Time"

    Science.gov (United States)

    Endo, Rachel

    2009-01-01

    This review situates how culture, difference, and identity are discursively constructed in "Millicent Min, Girl Genius" and "Stanford Wong Flunks Big-Time," two award-winning books written by critically acclaimed Asian American author Lisa Yee. Using contextual literacy approaches, the characters, cultural motifs, and physical settings in these…

  12. Trends in MD/PhD Graduates Entering Psychiatry: Assessing the Physician-Scientist Pipeline.

    Science.gov (United States)

    Arbuckle, Melissa R; Luo, Sean X; Pincus, Harold Alan; Gordon, Joshua A; Chung, Joyce Y; Chavez, Mark; Oquendo, Maria A

    2018-06-01

    The goal of this study was to identify trends in MD/PhD graduates entering psychiatry, to compare these trends with other specialties, and to review strategies for enhancing the physician-scientist pipeline. Data on 226,588 medical students graduating from Liaison Committee on Medical Education accredited programs between 1999 and 2012 (6626 MD/PhDs) were used to evaluate the number, percentage, and proportion of MD/PhDs entering psychiatry in comparison with other specialties (neurology, neurosurgery, internal medicine, family medicine, and radiation oncology). Linear regression and multiple linear regression determined whether these values increased over time and varied by sex. Over 14 years, an average of 18 MD/PhDs (range 13-29) enrolled in psychiatry each year. The number of MD/PhDs going into psychiatry significantly increased, although these gains were modest (less than one additional MD/PhD per year). The proportion of students entering psychiatry who were MD/PhDs varied between 2.9 and 5.9 per 100 residents, with no significant change over time. There was also no change in the percentage of MD/PhDs entering psychiatry from among all MD/PhD graduates. The rate of increase in the number of MD/PhDs going into psychiatry did not differ significantly from other specialties except for family medicine, which is decreasing. The rate of MD/PhDs going into psychiatry was higher for women, suggesting closure of the sex gap in 17 years. Despite the increase in the number of MD/PhDs entering psychiatry, these numbers remain low. Expanding the cohort of physician-scientists dedicated to translational research in psychiatry will require a multipronged approach.

  13. Analysis of MD5 authentication in various routing protocols using simulation tools

    Science.gov (United States)

    Dinakaran, M.; Darshan, K. N.; Patel, Harsh

    2017-11-01

    Authentication being an important paradigm of security and Computer Networks require secure paths to make the flow of the data even more secure through some security protocols. So MD-5(Message Digest 5) helps in providing data integrity to the data being sent through it and authentication to the network devices. This paper gives a brief introduction to the MD-5, simulation of the networks by including MD-5 authentication using various routing protocols like OSPF, EIGRP and RIPv2. GNS3 is being used to simulate the scenarios. Analysis of the MD-5 authentication is done in the later sections of the paper.

  14. What's new in management discussion and analysis (MD and A)

    International Nuclear Information System (INIS)

    Bradley, N.M.

    1998-01-01

    Disclosure obligations under the management and discussion analysis (MD and A) with respect to uncertainties regarding the millennium bug were discussed from a legal perspective. The year 2000 problem stems from the use of only two digits to represent the year in the date field throughout most computer programs, rendering computers unable to differentiate between the year 1900 and the year 2000. Companies should be aware that specific requirements have been imposed by securities regulators in Canada and the United States over and above the general continuous disclosure requirements. These new requirements are designed to assist companies to minimize their liability, and at the same time to motivate them to make progress in their Y2K efforts. Details of CSA Staff Notice 41-301 and 51-302 entitled 'The year 2000 challenge - Disclosure issues' and similar U.S. Securities and Stock Exchange requirements are reviewed. Specific examples of Y2K disclosure issues in the Canadian petroleum industry are described. 23 refs

  15. MD-11 PCA - View of aircraft on ramp

    Science.gov (United States)

    1995-01-01

    This McDonnell Douglas MD-11 is taxiing to a position on the flightline at NASA's Dryden Flight Research Center, Edwards, California, following its completion of the first and second landings ever performed by a transport aircraft under engine power only (on Aug. 29, 1995). The milestone flight, with NASA research pilot and former astronaut Gordon Fullerton at the controls, was part of a NASA project to develop a computer-assisted engine control system that enables a pilot to land a plane safely when its normal control surfaces are disabled. The Propulsion-Controlled Aircraft (PCA) system uses standard autopilot controls already present in the cockpit, together with the new programming in the aircraft's flight control computers. The PCA concept is simple. For pitch control, the program increases thrust to climb and reduces thrust to descend. To turn right, the autopilot increases the left engine thrust while decreasing the right engine thrust. The initial Propulsion-Controlled Aircraft studies by NASA were carried out at Dryden with a modified twin-engine F-15 research aircraft.

  16. MD-11 PCA - Closeup view of aircraft on ramp

    Science.gov (United States)

    1995-01-01

    This McDonnell Douglas MD-11 has taxied to a position on the flightline at NASA's Dryden Flight Research Center, Edwards, California, following its completion of the first and second landings ever performed by a transport aircraft under engine power only (on Aug. 29, 1995). The milestone flight, with NASA research pilot and former astronaut Gordon Fullerton at the controls, was part of a NASA project to develop a computer-assisted engine control system that enables a pilot to land a plane safely when its normal control surfaces are disabled. The Propulsion-Controlled Aircraft (PCA) system uses standard autopilot controls already present in the cockpit, together with the new programming in the aircraft's flight control computers. The PCA concept is simple. For pitch control, the program increases thrust to climb and reduces thrust to descend. To turn right, the autopilot increases the left engine thrust while decreasing the right engine thrust. The initial Propulsion-Controlled Aircraft studies by NASA were carried out at Dryden with a modified twin-engine F-15 research aircraft.

  17. MD#1182: Calibration of diamond particle detectors in IP6

    CERN Document Server

    Valette, Matthieu; Lindstrom, Bjorn Hans Filip; Wiesner, Christoph

    2017-01-01

    In case of an asynchronous beam dump with a fully filled LHC machine it is expected that all standard ionisation chamber Beam Loss Monitors (IC BLM) around the LHC dumping region in IP6 will be saturated. Diamond Beam Loss Monitors (dBLM) were therefore installed next to the movable dump protection absorber (TCDQ) downstream of the extraction kickers. These detectors allow resolving losses at a nanosecond timescale and with an dynamic range of several orders of magnitude; thus, allowing to know the number of nominal bunches impacting the TCDQ. After a first series of calibrations using asynchronous beam dump tests, an experiment was conducted during MD#1182 to demonstrate the possibility of resolving a nominal bunch hitting the TCDQ. The impact parameter of the bunches on the TCDQ was first scanned using probe bunches with lower intensity then tests were done with nominal bunches (1.1e11 p/bunch) at injection energy. High energy calibration of the losses was also attempted unsuccessfully. Due to different beh...

  18. Shallow boron dopant on silicon An MD study

    International Nuclear Information System (INIS)

    Perez-Martin, A. Mari Carmen; Jimenez-Rodriguez, Jose J.; Jimenez-Saez, Jose Carlos

    2004-01-01

    Low energy boron bombardment of silicon has been simulated at room temperature by molecular dynamics (MD). Tersoff potential T3 was used in the simulation smoothly linked up with the universal potential. The boron-silicon (B-Si) interaction was simulated according to Tersoff potential for SiC but modified to account for the B-Si interaction. The algorithm can distinguish a B from a Si neighbour. Si-c, with (2 x 1) surface reconstruction, was bombarded with boron at 200 and 500 eV. These energies were initially chosen as good representative values of the low energy range. Reliable results require of a reasonable good statistic so that 1000-impact points were chosen uniformly distributed over a representative area of a 2 x 1 surface. The distribution of mean projected range for B is given. All kinds of point defect were looked for in a Si damaged target after bombardment. Energetically stable substitutional and interstitial configurations are presented and the relative appearances of the different types of interstitials, for both Si and B, are given. It is also determined the mean length of the distance to the first neighbours of defects

  19. 76 FR 81826 - Drawbridge Operation Regulation; Pocomoke River, Pocomoke City, MD

    Science.gov (United States)

    2011-12-29

    ... Operation Regulation; Pocomoke River, Pocomoke City, MD AGENCY: Coast Guard, DHS. ACTION: Notice of... River, mile 15.6, at Pocomoke City, MD. The deviation restricts the operation of the draw span to... five hours advance notice is given. The Route 675 Bridge across Pocomoke River, mile 15.6 at Pocomoke...

  20. Possibilities of production of neutron-rich Md isotopes in multi-nucleon transfer reactions

    Energy Technology Data Exchange (ETDEWEB)

    Mun, Myeong-Hwan; Lee, Young-Ouk [Korea Atomic Energy Research Institue, Daejeon (Korea, Republic of); Adamian, G.G.; Antonenko, N.V. [Joint Institute for Nuclear Research, Dubna (Russian Federation)

    2016-12-15

    The possibilities of production of yet unknown neutron-rich isotopes of Md are explored in several multi-nucleon transfer reactions with actinide targets and stable and radioactive beams. The projectile-target combinations and bombarding energies are suggested to produce new neutron-rich isotopes of Md in future experiments. (orig.)

  1. 77 FR 29692 - Segun M. Rasaki, M.D.; Decision and Order

    Science.gov (United States)

    2012-05-18

    ... CFR 1316.67. Dated: May 4, 2012. Michele M. Leonhart, Administrator. Paul E. Soeffing, Esq., for the... reinstatement.'' Stuart A. Bergman, M.D., 70 Fed. Reg. 33,193 (DEA 2005); Roger A. Rodriguez, M.D., 70 Fed. Reg...

  2. 78 FR 47412 - Tyson D. Quy, M.D.; Decision and Order

    Science.gov (United States)

    2013-08-05

    ... Green, Jr., M.D., 59 FR 51,453 (DEA 1994); David E. Trawick, D.D.S., 53 FR 5,326 (DEA 1988). Here, the...) (ten years); Norman Alpert, M.D., 58 FR 67,420, 67,421 (DEA 1993) (seven years). Here, the conditions...

  3. 75 FR 76688 - Drawbridge Operation Regulation; Isle of Wight (Sinepuxent) Bay, Ocean City, MD

    Science.gov (United States)

    2010-12-09

    ..., mile 0.5, at Ocean City, with a vertical clearance of 13 feet above mean high tide in the closed...-AA09 Drawbridge Operation Regulation; Isle of Wight (Sinepuxent) Bay, Ocean City, MD AGENCY: Coast... Ocean City, MD. This proposed rule will require any mariner requesting an opening in the evening hours...

  4. 76 FR 17673 - Bienvenido Tan, M.D.; Denial of Application

    Science.gov (United States)

    2011-03-30

    ... (alprazolam) to help him sleep. Id. at 64. R.E. opted to buy the drugs from Respondent's dispensary and... DEPARTMENT OF JUSTICE Drug Enforcement Administration [Docket No. 09-12] Bienvenido Tan, M.D... Control, Drug Enforcement Administration, issued an Order to Show Cause to Bienvenido Tan, M.D...

  5. 76 FR 15214 - Special Local Regulations for Marine Events; Potomac River, Charles County, MD

    Science.gov (United States)

    2011-03-21

    ...-AA08 Special Local Regulations for Marine Events; Potomac River, Charles County, MD AGENCY: Coast Guard... for Marine Events; Potomac River, Charles County, MD'' in the Federal Register (76 FR 1381). We... follows: Sec. 100.35-T05-1113 Special Local Regulations for Marine Events; Potomac River, Charles County...

  6. 77 FR 6708 - Special Local Regulations for Marine Events; Potomac River, Charles County, MD

    Science.gov (United States)

    2012-02-09

    ...-AA08 Special Local Regulations for Marine Events; Potomac River, Charles County, MD AGENCY: Coast Guard... River, Charles County, MD. (a) Regulated area. The following location is a regulated area: All waters of... local regulations during the ``Potomac River Sharkfest Swim'' amateur swim, a marine event to be held on...

  7. 76 FR 1381 - Special Local Regulations for Marine Events; Potomac River, Charles County, MD

    Science.gov (United States)

    2011-01-10

    ...-AA08 Special Local Regulations for Marine Events; Potomac River, Charles County, MD AGENCY: Coast Guard... Regulations for Marine Events; Potomac River, Charles County, MD. (a) Regulated area. The following location... local regulations during the ``Potomac River Sharkfest Swim'' amateur swim, a marine event to be held on...

  8. 33 CFR 110.70a - Northeast River, North East, Md.

    Science.gov (United States)

    2010-07-01

    ... 33 Navigation and Navigable Waters 1 2010-07-01 2010-07-01 false Northeast River, North East, Md. 110.70a Section 110.70a Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY ANCHORAGES ANCHORAGE REGULATIONS Special Anchorage Areas § 110.70a Northeast River, North East, Md. The water...

  9. Functional Characterization of the Apple RING E3 Ligase MdMIEL1 in Transgenic Arabidopsis

    Directory of Open Access Journals (Sweden)

    Jianping AN

    2017-03-01

    Full Text Available E3 ubiquitin ligases are involved in various physiological processes, and they play pivotal roles in growth and development. In this study, we identified a previously unknown gene in the apple fruit (Malus × domestica and named it MdMIEL1. The MdMIEL1 gene encoded a protein that contained a zinc-finger domain at its N-terminus and a RING-finger motif at its C-terminus. To investigate MdMIEL1 functions, we generated transgenic Arabidopsis lines expressing the MdMIEL1 gene under the control of the Cauliflower mosaic virus 35S promoter. Interestingly, ectopic expression of MdMIEL1 in Arabidopsis produced multiple phenotypes, including early germination, early flowering and a lateral root number increase relative to wild-type plants. Further analysis indicated that MdMIEL1 regulated lateral root initiation by increasing auxin accumulation in the roots. In a word, these results suggest that, MdMIEL1 as a novel RING-finger ubiquitin ligase influences plant growth and development, and highlight that MdMIEL1 regulates lateral root growth.

  10. 77 FR 35021 - Kwan Bo Jin, M.D.; Decision and Order

    Science.gov (United States)

    2012-06-12

    ...] DEA registration is not appropriate.'' Anibal P. Herrera, M.D., 61 FR 65,075, 65,078 (DEA 1996); see... ``there were serious questions as to the integrity of the registrant.'' Anibal P. Herrera, M.D., 61 FR 65...

  11. Avaliação do desempenho visual da lente intraocular difrativa multifocal - Zeiss AT Lisa 809 MTM

    Directory of Open Access Journals (Sweden)

    Lucas Monferrari Monteiro Vianna

    2014-04-01

    Full Text Available Objetivo: Avaliar a função visual dos pacientes com implante bilateral da LIO multifocal difrativa AT-Lisa 809 MTM por meio dos exames de acuidade visual com e sem correção óptica, curva de sensibilidade ao contraste, curva de desfoco e questionário de qualidade de função visual (VQF39. Métodos: Estudo clínico, prospectivo e de intervenção, que avaliou os resultados de 20 olhos de 10 pacientes, submetidos à facoemulsificação e implante de LIO, entre fevereiro e junho de 2012. Resultados: A ametropia residual média pós-operatória foi de 0,05 ± 0,42 (-0,75 a +1,25 D dioptrias esféricas e -0,30 ± 0,42 (0 a -1,25 D dioptrias cilíndricas. Na curva de desenfoque mono e binocular, a melhor acuidade visual média obtida com 0.00 D de desenfoque (AV de longe. O segundo pico foi obtido com desenfoque de -3,00 D, o que equivale à visão de perto a 33 cm. Entre esses picos, observamos uma perda de desempenho visual, com desenfoque de -2,00 D, que equivale a visão intermediária a 50 cm. A sensibilidade ao contraste foi similar aos relatados na literatura com este tipo de LIO, tanto com quanto sem ofuscamento, e é mostrada em gráficos. O questionário de função visual (VFQ-39 teve valor médio de 91,91 +- 6,82. Conclusão: A LIO multifocal difrativa AT-Lisa 809MTM (Carl Zeiss Meditec Company - Alemanha apresentou resultados condizentes com a literatura quando avaliada pelos exames de acuidade visual com e sem correção óptica, sensibilidade ao contraste, curva de desfoco e questionário de qualidade de função visual (VQF 39.

  12. On-ground testing of the role of adhesion in the LISA-Pathfinder test mass injection phase

    Science.gov (United States)

    Bortoluzzi, D.; Zanoni, C.; Conklin, J. W.

    2017-05-01

    Many space missions share the need to fly a free-falling body inside the spacecraft, as a reference for navigation and/or as a probe for the local gravitational field. When a mechanism is required to cage such an object during the launch phase, the need arises to release it to free-fall once the operational phase must be initiated in orbit. The criticality of this phase increases when the mechanical interfaces between the body and the mechanism are affected by adhesion and the actuation authority of the control system on the free-falling body is limited. Both conditions are realized in the LISA Pathfinder mission, which aims at injecting a gold-coated 2 kg cubic test mass into a nearly perfect geodesic trajectory to demonstrate the readiness of the developed technology for in-space gravity wave detection. The criticality of adhesion is widely recognized in space technology, because it can affect and jeopardize the functionality of mechanisms, when arising between moving parts. In the LISA Pathfinder case, metallic adhesion potentially plays a relevant role, mainly for two reasons. First, thanks to its properties (ductility, high surface energy) the gold coating on the proof mass easily produces cold weldings, especially in vacuum conditions. Second, the detachment of the proof mass from the releasing device occurs abruptly and a relevant influence of the separation velocity is expected on the strength of the welding. This can produce an excessive velocity of the proof mass at the retraction of the releasing device for the following capture and centring phase on behalf of the control system. A testing activity is performed to characterize the dynamic behaviour of the adhesive bonds between the proof mass and the releasing device, which can be used to predict their contribution on the residual velocity of the proof mass after in-flight release. The study of such a dynamic phenomenon sets some challenging requirements on the measurement technique, both on the

  13. William Bradley Coley, MD, and the phenomenon of spontaneous regression

    Directory of Open Access Journals (Sweden)

    Vernon LF

    2018-04-01

    Full Text Available Leonard F Vernon Sherman College of Chiropractic, Spartanburg, SC, USA Abstract: The standard definition of spontaneous regression (SR of cancer is as follows, “…when a malignant tumor partially or completely disappears without treatment or in the presence of therapy which is considered inadequate to exert a significant influence on neoplastic disease.” SR is also known as Saint Peregrine tumor, the name taken from a young priest, Peregrine Laziosi (1260 [5]–1345, exact date is unknown, who had been diagnosed with a tumor of the tibia. The mass eventually grew so large that it broke through the skin and became severely infected. The available treatment for this condition was limited to amputation. Historical records report that on the day of surgery, physicians found that the tumor had disappeared and reportedly never returned. To date, the medical literature consists only of individual case studies and overviews of this phenomenon. The most cited work on the subject was done by surgeons Tilden Everson and Warren Cole who reviewed 176 published cases of SR from 1900 to 1960. While a percentage of these were found not to be cases of SR, there remained a number of unexplained cases. A frequent theme in many cases of SR is the co-occurrence of infection. Given the current interest in immunotherapy in the treatment of cancer, this article discusses one of the very early pioneers of this theory, William Bradley Coley, MD, a surgeon who was clearly ahead of his time. Ostracized by colleagues for his belief that stimulation of the immune system could in fact produce a regression of cancer, Coley remained convinced that his theory was right and, while he was not familiar with cytokines such as tumor necrosis factor (TNF, interferons, and streptokinase, he knew instinctively that an innate immune response was taking place. Keywords: autoimmunity, cancer, fever, infection, immunotherapy, tumor, cytokines

  14. Milestone report on MD potential development for uranium silicide

    International Nuclear Information System (INIS)

    Yu, Jianguo; Zhang, Yongfeng; Hales, Jason Dean

    2016-01-01

    This report summarizes the progress on the interatomic potential development of triuranium-disilicide (U 3 Si 2 ) for molecular dynamics (MD) simulations. The development is based on the Tersoff type potentials for single element U and Si. The Si potential is taken from the literature and a Tersoff type U potential is developed in this project. With the primary focus on the U 3 Si 2 phase, some other U-Si systems such as U 3 Si are also included as a test of the transferability of the potentials for binary U-Si phases. Based on the potentials for unary U and Si, two sets of parameters for the binary U-Si system are developed using the Tersoff mixing rules and the cross-term fitting, respectively. The cross-term potential is found to give better results on the enthalpy of formation, lattice constants and elastic constants than those produced by the Tersoff mixing potential, with the reference data taken from either experiments or density functional theory (DFT) calculations. In particular, the results on the formation enthalpy and lattice constants for the U 3 Si 2 phase and lattice constants for the high temperature U 3 Si (h-U 3 Si) phase generated by the cross-term potential agree well with experimental data. Reasonable agreements are also reached on the elastic constants of U 3 Si 2 , on the formation enthalpy for the low temperature U 3 Si (m-U 3 Si) and h-U 3 Si phases, and on the lattice constants of m-U 3 Si phase. All these phases are predicted to be mechanically stable. The unary U potential is tested for three metallic U phases (α, β, γ). The potential is found capable to predict the cohesive energies well against experimental data for all three phases. It matches reasonably with previous experiments on the lattice constants and elastic constants of αU.

  15. Searching for galactic white-dwarf binaries in mock LISA data using an F-statistic template bank

    International Nuclear Information System (INIS)

    Whelan, John T; Prix, Reinhard; Khurana, Deepak

    2010-01-01

    We describe an F-statistic search for continuous gravitational waves from galactic white-dwarf binaries in simulated LISA data. Our search method employs a hierarchical template-grid-based exploration of the parameter space. In the first stage, candidate sources are identified in searches using different simulated laser signal combinations (known as TDI variables). Since each source generates a primary maximum near its true 'Doppler parameters' (intrinsic frequency and sky position) as well as numerous secondary maxima of the F-statistic in Doppler parameter space, a search for multiple sources needs to distinguish between true signals and secondary maxima associated with other 'louder' signals. Our method does this by applying a coincidence test to reject candidates which are not found at nearby parameter space positions in searches using each of the three TDI variables. For signals surviving the coincidence test, we perform a fully coherent search over a refined parameter grid to provide an accurate parameter estimation for the final candidates. Suitably tuned, the pipeline is able to extract 1989 true signals with only 5 false alarms. The use of the rigid adiabatic approximation allows recovery of signal parameters with errors comparable to statistical expectations, although there is still some systematic excess with respect to statistical errors expected from Gaussian noise. An experimental iterative pipeline with seven rounds of signal subtraction and reanalysis of the residuals allows us to increase the number of signals recovered to a total of 3419 with 29 false alarms.

  16. Measurement of the momentum transferred between contacting bodies during the LISA test-mass release phase—uncertainty estimation

    International Nuclear Information System (INIS)

    De Cecco, M; Bortoluzzi, D; Da Lio, M; Baglivo, L; Benedetti, M

    2009-01-01

    The requirements for the Laser Interferometer Space Antenna (LISA) test-mass (TM) release phase are analysed in view of the building up of a testing facility aimed at on-Earth qualification of the release mechanism. Accordingly, the release of the TM to free-fall must provide a linear momentum transferred to the TM not exceeding 10 −5 kg m s −1 . In order to test this requirement, a double pendulum system has been developed. The mock-ups of the TM and the release-dedicated plunger are brought into contact and then the latter is quickly retracted. During and after release, the TM motion is measured by a laser interferometer. The transferred momentum is estimated from the free oscillations following the plunger retraction by means of a Wiener–Kolmogorov optimal filter. This work is aimed at modelling the measurement chain, taking into account procedure, instruments, mechanisms and data elaboration in order to estimate the uncertainty associated with the transferred momentum measurement by means of Monte Carlo simulation

  17. Fundamental performance determining factors of the ultrahigh-precision space-borne optical metrology system for the LISA Pathfinder mission

    Science.gov (United States)

    Hechenblaikner, Gerald; Flatscher, Reinhold

    2013-05-01

    The LISA Pathfinder mission to space employs an optical metrology system (OMS) at its core to measure the distance and attitude between two freely floating test-masses to picometer and nanorad accuracy, respectively, within the measurement band of [1 mHz, 30 mHz]. The OMS is based upon an ultra-stable optical bench with 4 heterodyne interferometers from which interference signals are read-out and processed by a digital phase-meter. Laser frequency noise, power fluctuations and optical path-length variations are suppressed to uncritical levels by dedicated control loops so that the measurement performance approaches the sensor limit imposed by the phasemeter. The system design is such that low frequency common mode noise which affects the read-out phase of all four interferometers is generally well suppressed by subtraction of a reference phase from the other interferometer signals. However, high frequency noise directly affects measurement performance and its common mode rejection depends strongly on the relative signal phases. We discuss how the data from recent test campaigns point towards high frequency phase noise as a likely performance limiting factor which explains some important performance features.

  18. Searching for galactic white-dwarf binaries in mock LISA data using an F-statistic template bank

    Energy Technology Data Exchange (ETDEWEB)

    Whelan, John T [Center for Computational Relativity and Gravitation, School of Mathematical Sciences, Rochester Institute of Technology, 85 Lomb Memorial Drive, Rochester, NY 14623 (United States); Prix, Reinhard [Max-Planck-Institut fuer Gravitationsphysik (Albert-Einstein-Institut), D-30167 Hannover (Germany); Khurana, Deepak, E-mail: john.whelan@astro.rit.ed, E-mail: reinhard.prix@aei.mpg.d [Indian Institute of Technology, Kharagpur, West Bengal 721302 (India)

    2010-03-07

    We describe an F-statistic search for continuous gravitational waves from galactic white-dwarf binaries in simulated LISA data. Our search method employs a hierarchical template-grid-based exploration of the parameter space. In the first stage, candidate sources are identified in searches using different simulated laser signal combinations (known as TDI variables). Since each source generates a primary maximum near its true 'Doppler parameters' (intrinsic frequency and sky position) as well as numerous secondary maxima of the F-statistic in Doppler parameter space, a search for multiple sources needs to distinguish between true signals and secondary maxima associated with other 'louder' signals. Our method does this by applying a coincidence test to reject candidates which are not found at nearby parameter space positions in searches using each of the three TDI variables. For signals surviving the coincidence test, we perform a fully coherent search over a refined parameter grid to provide an accurate parameter estimation for the final candidates. Suitably tuned, the pipeline is able to extract 1989 true signals with only 5 false alarms. The use of the rigid adiabatic approximation allows recovery of signal parameters with errors comparable to statistical expectations, although there is still some systematic excess with respect to statistical errors expected from Gaussian noise. An experimental iterative pipeline with seven rounds of signal subtraction and reanalysis of the residuals allows us to increase the number of signals recovered to a total of 3419 with 29 false alarms.

  19. Design and construction of an optical test bed for LISA imaging systems and tilt-to-length coupling

    International Nuclear Information System (INIS)

    Chwalla, M; Fitzsimons, E; Danzmann, K; Fernández Barranco, G; Gerberding, O; Heinzel, G; Lieser, M; Schuster, S; Schwarze, T S; Tröbs, M; Zwetz, M; Killow, C J; Perreur-Lloyd, M; Robertson, D I; Ward, H

    2016-01-01

    The laser interferometer space antenna (LISA) is a future space-based interferometric gravitational-wave detector consisting of three spacecraft in a triangular configuration. The interferometric measurements of path length changes between satellites will be performed on optical benches in the satellites. Angular misalignments of the interfering beams couple into the length measurement and represent a significant noise source. Imaging systems will be used to reduce this tilt-to-length coupling. We designed and constructed an optical test bed to experimentally investigate tilt-to-length coupling. It consists of two separate structures, a minimal optical bench and a telescope simulator. The minimal optical bench comprises the science interferometer where the local laser is interfered with light from a remote spacecraft. In our experiment, a simulated version of this received beam is generated on the telescope simulator. The telescope simulator provides a tilting beam, a reference interferometer and an additional static beam as a phase reference. The tilting beam can either be a flat-top beam or a Gaussian beam. We avoid tilt-to-length coupling in the reference interferometer by using a small photo diode placed at an image of the beam rotation point. We show that the test bed is operational with an initial measurement of tilt-to-length coupling without imaging systems. Furthermore, we show the design of two different imaging systems whose performance will be investigated in future experiments. (paper)

  20. Diseño de un plan de marketing para el producto lisa college desarrollado por la microempresa browse Ecuador, ubicada en la ciudad de Quito.

    OpenAIRE

    Coello Duque, Giomar Evelyn

    2013-01-01

    The present work aims to make a marketing plan for the product developed by Lisa College microenterprise Browse Ecuador Cia. Ltd. and it will be a guide for other micros companies wishing to conduct similar research. First, we review general information about the company under study in order to identify problems, research objectives and delimitation of the research area. With this knowledge provides the theoretical and conceptual framework underpinning this research. The ...

  1. Science with the space-based interferometer eLISA. III: probing the expansion of the universe using gravitational wave standard sirens

    Energy Technology Data Exchange (ETDEWEB)

    Tamanini, Nicola; Caprini, Chiara [Institut de Physique Théorique, CEA-Saclay, CNRS UMR 3681, Université Paris-Saclay, F-91191 Gif-sur-Yvette (France); Barausse, Enrico [Sorbonne Universités, UPMC Université Paris 6, UMR 7095, Institut d' Astrophysique de Paris, 98 bis Bd Arago, 75014 Paris (France); Sesana, Alberto [School of Physics and Astronomy, The University of Birmingham, Edgbaston, Birmingham B15 2TT (United Kingdom); Klein, Antoine [Department of Physics and Astronomy, The University of Mississippi, University, MS 38677 (United States); Petiteau, Antoine, E-mail: nicola.tamanini@cea.fr, E-mail: chiara.caprini@cea.fr, E-mail: barausse@iap.fr, E-mail: asesana@star.sr.bham.ac.uk, E-mail: aklein@physics.montana.edu, E-mail: antoine.petiteau@apc.univ-paris7.fr [APC, Université Paris Diderot, Observatoire de Paris, Sorbonne Paris Cité, 10 rue Alice Domon et Léonie Duquet, 75205 Paris Cedex 13 (France)

    2016-04-01

    We investigate the capability of various configurations of the space interferometer eLISA to probe the late-time background expansion of the universe using gravitational wave standard sirens. We simulate catalogues of standard sirens composed by massive black hole binaries whose gravitational radiation is detectable by eLISA, and which are likely to produce an electromagnetic counterpart observable by future surveys. The main issue for the identification of a counterpart resides in the capability of obtaining an accurate enough sky localisation with eLISA. This seriously challenges the capability of four-link (2 arm) configurations to successfully constrain the cosmological parameters. Conversely, six-link (3 arm) configurations have the potential to provide a test of the expansion of the universe up to z ∼ 8 which is complementary to other cosmological probes based on electromagnetic observations only. In particular, in the most favourable scenarios, they can provide a significant constraint on H{sub 0} at the level of 0.5%. Furthermore, (Ω{sub M}, Ω{sub Λ}) can be constrained to a level competitive with present SNIa results. On the other hand, the lack of massive black hole binary standard sirens at low redshift allows to constrain dark energy only at the level of few percent.

  2. Nested-PCR and a new ELISA-based NovaLisa test kit for malaria diagnosis in an endemic area of Thailand.

    Science.gov (United States)

    Thongdee, Pimwan; Chaijaroenkul, Wanna; Kuesap, Jiraporn; Na-Bangchang, Kesara

    2014-08-01

    Microscopy is considered as the gold standard for malaria diagnosis although its wide application is limited by the requirement of highly experienced microscopists. PCR and serological tests provide efficient diagnostic performance and have been applied for malaria diagnosis and research. The aim of this study was to investigate the diagnostic performance of nested PCR and a recently developed an ELISA-based new rapid diagnosis test (RDT), NovaLisa test kit, for diagnosis of malaria infection, using microscopic method as the gold standard. The performance of nested-PCR as a malaria diagnostic tool is excellent with respect to its high accuracy, sensitivity, specificity, and ability to discriminate Plasmodium species. The sensitivity and specificity of nested-PCR compared with the microscopic method for detection of Plasmodium falciparum, Plasmodium vivax, and P. falciparum/P. vivax mixed infection were 71.4 vs 100%, 100 vs 98.7%, and 100 vs 95.0%, respectively. The sensitivity and specificity of the ELISA-based NovaLisa test kit compared with the microscopic method for detection of Plasmodium genus were 89.0 vs 91.6%, respectively. NovaLisa test kit provided comparable diagnostic performance. Its relatively low cost, simplicity, and rapidity enables large scale field application.

  3. Apple F-box Protein MdMAX2 Regulates Plant Photomorphogenesis and Stress Response

    Directory of Open Access Journals (Sweden)

    Jian-Ping An

    2016-11-01

    Full Text Available MAX2 (MORE AXILLARY GROWTH2 is involved in diverse physiological processes, including photomorphogenesis, the abiotic stress response, as well as karrikin and strigolactone signaling-mediated shoot branching. In this study, MdMAX2, an F-box protein that is a homolog of Arabidopsis MAX2, was identified and characterized. Overexpression of MdMAX2 in apple calli enhanced the accumulation of anthocyanin. Ectopic expression of MdMAX2 in Arabidopsis exhibited photomorphogenesis phenotypes, including increased anthocyanin content and decreased hypocotyl length. Further study indicated that MdMAX2 might promote plant photomorphogenesis by affecting the auxin signaling as well as other plant hormones. Transcripts of MdMAX2 were noticeably up-regulated in response to NaCl and Mannitol treatments. Moreover, compared with the wild type, the MdMAX2-overexpressing apple calli and Arabidopsis exhibited increased tolerance to salt and drought stresses. Taken together, these results suggest that MdMAX2 plays a positive regulatory role in plant photomorphogenesis and stress response.

  4. Sustainable water recovery from oily wastewater via forward osmosis-membrane distillation (FO-MD).

    Science.gov (United States)

    Zhang, Sui; Wang, Peng; Fu, Xiuzhu; Chung, Tai-Shung

    2014-04-01

    This study proposed and investigated a hybrid forward osmosis - membrane distillation (FO-MD) system for sustainable water recovery from oily wastewater by employing lab-fabricated FO and MD hollow fiber membranes. Stable oil-in-water emulsions of different concentrations with small droplet sizes (oil droplets and partial permeation of acetic acid could be achieved. Finally, an integrated FO-MD system was developed to treat the oily wastewater containing petroleum, surfactant, NaCl and acetic acid at 60 °C in the batch mode. The water flux in FO undergoes three-stage decline due to fouling and reduction in osmotic driving force, but is quite stable in MD regardless of salt concentration. Oily wastewater with relatively high salinity could be effectively recovered by the FO-MD hybrid system while maintaining large water flux, at least 90% feed water recovery could be readily attained with only trace amounts of oil and salts, and the draw solution was re-generated for the next rounds of FO-MD run. Interestingly, significant amount of acetic acid was also retained in the permeate for further reuse as a chemical additive during the production of crude oil. The work has demonstrated that not only water but also organic additives in the wastewater could be effectively recovered by FO-MD systems for reuse or other utilizations. Copyright © 2014 Elsevier Ltd. All rights reserved.

  5. Characterization of an Autophagy-related Gene MdATG8i from apple

    Directory of Open Access Journals (Sweden)

    Ping eWang

    2016-05-01

    Full Text Available Nutrient deficiencies restrict apple (Malus sp. tree growth and productivity in Northwest China. The process of autophagy, a conserved degradation pathway in eukaryotic cells, has important roles in nutrient-recycling and helps improve plant performance during periods of nutrient-starvation. Little is known about the functioning of autophagy-related genes (ATGs in apple. In this study, one of the ATG8 gene family members MdATG8i was isolated from M. domestica. MdATG8i has conserved putative tubulin binding sites and ATG7 interaction domains. A 1865-bp promoter region cloned from apple genome DNA was predicated to have cis-regulatory elements responsive to light, environmental stresses and hormones. MdATG8i transcriptions were induced in response to leaf senescence, nitrogen depletion, and oxidative stress. At cellular level, MdATG8i protein was expressed in the nucleus and cytoplasm of onion epidermal cells. Yeast two-hybrid tests showed that MdATG8i could interact with MdATG7a and MdATG7b. In Arabidopsis, its heterologous expression was associated with enhanced vegetative growth, leaf senescence, and tolerance to nitrogen- and carbon-starvation. MdATG8i-overexpressing ‘Orin’ apple callus lines also displayed improved tolerance to nutrient-limited conditions. Our results demonstrate that MdATG8i protein could function in autophagy in a conserved way, as a positive regulator in the response to nutrient-starvation.

  6. Milestone report on MD potential development for uranium silicide

    Energy Technology Data Exchange (ETDEWEB)

    Yu, Jianguo [Idaho National Lab. (INL), Idaho Falls, ID (United States). Fuel Modeling and Simulation Dept.; Zhang, Yongfeng [Idaho National Lab. (INL), Idaho Falls, ID (United States). Fuel Modeling and Simulation Dept.; Hales, Jason Dean [Idaho National Lab. (INL), Idaho Falls, ID (United States). Fuel Modeling and Simulation Dept.

    2016-03-01

    This report summarizes the progress on the interatomic potential development of triuranium-disilicide (U3Si2) for molecular dynamics (MD) simulations. The development is based on the Tersoff type potentials for single element U and Si. The Si potential is taken from the literature and a Tersoff type U potential is developed in this project. With the primary focus on the U3Si2 phase, some other U-Si systems such as U3Si are also included as a test of the transferability of the potentials for binary U-Si phases. Based on the potentials for unary U and Si, two sets of parameters for the binary U-Si system are developed using the Tersoff mixing rules and the cross-term fitting, respectively. The cross-term potential is found to give better results on the enthalpy of formation, lattice constants and elastic constants than those produced by the Tersoff mixing potential, with the reference data taken from either experiments or density functional theory (DFT) calculations. In particular, the results on the formation enthalpy and lattice constants for the U3Si2 phase and lattice constants for the high temperature U3Si (h-U3Si) phase generated by the cross-term potential agree well with experimental data. Reasonable agreements are also reached on the elastic constants of U3Si2, on the formation enthalpy for the low temperature U3Si (m-U3Si) and h-U3Si phases, and on the lattice constants of m-U3Si phase. All these phases are predicted to be mechanically stable. The unary U potential is tested for three metallic U phases (α, β, γ). The potential is found capable to predict the cohesive energies well against experimental data for all three phases. It matches reasonably with previous experiments on the lattice constants and elastic constants of αU.

  7. The core competencies of James Marion Sims, MD.

    Science.gov (United States)

    Straughn, J Michael; Gandy, Roy E; Rodning, Charles B

    2012-07-01

    The concept of core competencies in graduate medical education was introduced by the Accreditation Council for Graduate Medical Education of the American Medical Association to semiquantitatively assess the professional performance of students, residents, practitioners, and faculty. Many aspects of the career of J. Marion Sims, MD, are exemplary of those core competencies: MEDICAL KNOWLEDGE: Author of the first American textbook related to gynecology. MEDICAL CARE: Innovator of the Sims' Vaginal Speculum, Sims' Position, Sims' Test, and vesico-/rectovaginal fistulorrhaphy; advocated abdominal exploration for penetrating wounds; performed the first cholecystostomy. PROFESSIONALISM: Served as President of the New York Academy of Medicine, the American Medical Association, and the American Gynecologic Society. INTERPERSONAL RELATIONSHIPS/COMMUNICATION: Cared for the indigent, hearthless, indentured, disenfranchised; served as consulting surgeon to the Empress Eugénie (France), the Duchess of Hamilton (Scotland), the Empress of Austria, and other royalty of the aristocratic Houses of Europe; accorded the National Order of the Legion of Honor. PRACTICE-BASED LEARNING: Introduction of silver wire sutures; adoption of the principles of asepsis/antisepsis; adoption of the principles of general anesthesia. SYSTEMS-BASED PRACTICE: Established the Woman's Hospital, New York City, New York, the predecessor of the Memorial Sloan-Kettering Center for the Treatment of Cancer and Allied Diseases; organized the Anglo-American Ambulance Corps under the patronage of Napoleon III. What led him to a life of clinical and humanitarian service? First, he was determined to succeed. His formal medical/surgical education was perhaps the best available to North Americans during that era. Second, he was courageous in experimentation and innovation, applying new developments in operative technique, asepsis/antisepsis, and general anesthesia. Third, his curiosity was not burdened by rigid

  8. Osmotically and thermally isolated forward osmosis-membrane distillation (fo-md) integrated module for water treatment applications

    KAUST Repository

    Ghaffour, Noreddine

    2016-09-01

    An integrated forward osmosis-membrane distillation (FO-MD) module and systems and methods incorporating the module is disclosed providing higher efficiencies and using less energy. The FO-MD module is osmotically and thermally isolated. The isolation can prevent mixing of FO draw solution/FO permeate and MD feed, and minimize dilution of FO draw solution and cooling of MD feed. The module provides MD feed solution and FO draw solution streams that flow in the same module but are separated by an isolation barrier. The osmotically and thermally isolated FO-MD integrated module, systems and methods offer higher driving forces of both FO and MD processes, higher recovery, and wider application than previously proposed hybrid FO- MD systems.

  9. Osmotically and thermally isolated forward osmosis-membrane distillation (fo-md) integrated module for water treatment applications

    KAUST Repository

    Ghaffour, NorEddine; Francis, Lijo; Li, Zhenyu; Valladares, Rodrigo; Alsaadi, Ahmad S.; Ghdaib, Muhannad Abu; Amy, Gary L.

    2016-01-01

    An integrated forward osmosis-membrane distillation (FO-MD) module and systems and methods incorporating the module is disclosed providing higher efficiencies and using less energy. The FO-MD module is osmotically and thermally isolated. The isolation can prevent mixing of FO draw solution/FO permeate and MD feed, and minimize dilution of FO draw solution and cooling of MD feed. The module provides MD feed solution and FO draw solution streams that flow in the same module but are separated by an isolation barrier. The osmotically and thermally isolated FO-MD integrated module, systems and methods offer higher driving forces of both FO and MD processes, higher recovery, and wider application than previously proposed hybrid FO- MD systems.

  10. MD 2485: Active halo control using narrowband and colored noise excitations

    CERN Document Server

    Garcia Morales, Hector; Kotzian, Gerd; Maclean, Ewen Hamish; Redaelli, Stefano; Valuch, Daniel; Wagner, Joschka; CERN. Geneva. ATS Department

    2018-01-01

    This MD note summarizes the actions carried out during the MD 2485 on Active halo control using narrowband and colored noise excitations. The goal of the MD was to repeat some promising cases already tested in the past and introduce a new excitation type based on applying a colored noise. Although we were able to repeat some cases using a narrowband excitation, due to a problem with the waveform generator, the colored noise excitation could not be accomplished as expected. In any case, we provide some results that may be useful for future MDs.

  11. Molecular Cloning and Expression Analysis of a Hexokinase Gene, MdHXK1 in Apple

    Directory of Open Access Journals (Sweden)

    Jin Zhao

    2016-03-01

    Full Text Available A hexokinase gene named MdHXK1 (MDP0000309677 was cloned from ‘Gala’ apple (Malus × domestica Borkh.. Sequence analysis showed that the MdHXK1 gene was 1 497 bp long and encoded 499 amino acids. The predicted molecular mass of this protein was 54.05 kD, and the pI was 5.76. A phylogenetic tree indicated apple MdHXK1 exhibited the highest sequence similarity to Pyrus bretschneideri PbHXK1. Analysis of the functional domain showed that the MdHXK1 protein included two conserved kinase domains. The prediction of subcellular localization suggested that the MdHXK1 protein was mainly localized in the cytoplasm. There was an indication that MdHXK1 existed as one copy in the apple genome by Southern blotting. Silico analysis suggested that the promoter sequence contained several typical cis-acting elements, including defense, sugar signaling and phytohormone responsive elements. Quantitative real-time PCR analysis demonstrated that the MdHXK1 gene was mainly expressed in stem and flower tissues. During the development of apple fruits, the expression of the MdHXK1 gene initially increased and then decreased. The changes on Glc phosphorylation relative activity and glucose concentration showed the same trend. In addition, the expression of this gene was induced by salt stress, low temperature, and abscisic acid (ABA. Finally, we obtained and purified the fused MdHXK1 protein by recombinant prokaryotic expression. Studies have demonstrated that MdHXK1 may participate in sugar metabolism in apple fruits. Enzyme encoded by MdHXK1 is a key factor in the mediation of sugar accumulation. Recently, researchers on hexokinase at home and abroad mainly focused on model plants, such as Arabidopsis, tobacco and rice, but orchard fruit like apple were underresearched. Our research established the foundation for the further study of the functions of MdHXK1.

  12. In-situ Air Temperature and Relative Humidity in Greenbelt, MD, 2013-2015

    Data.gov (United States)

    National Aeronautics and Space Administration — This data set describes the temperature and relative humidity at 12 locations around Goddard Space Flight Center in Greenbelt MD at 15 minute intervals between...

  13. 75 FR 8193 - Jeri Hassman, M.D.; Denial of Application

    Science.gov (United States)

    2010-02-23

    ... is buying drugs on the street. Id. at 1006. With respect to requests for early refills, Dr. Hare... Part II Department of Justice Drug Enforcement Administration Jeri Hassman, M.D.; Denial of...; [[Page 8194

  14. Metabolic engineering of apple by overexpression of the MdMyb10 gene

    Directory of Open Access Journals (Sweden)

    Khaled A.L. Rihani

    2017-06-01

    In the present study, the flavonoid pathway was successfully modified in apple by overexpressing the MdMyb10 transcription factor to validate the hypothesis of increased effect on plant disease resistance.

  15. 78 FR 32556 - Safety Zone; 2013 Ocean City Air Show, Atlantic Ocean; Ocean City, MD

    Science.gov (United States)

    2013-05-31

    ... FR Federal Register NPRM Notice of Proposed Rulemaking A. Regulatory History and Information The... Atlantic Ocean in Ocean City, MD. In recent years, there have been unfortunate instances of jets and planes...

  16. Image fusion in craniofacial virtual reality modeling based on CT and 3dMD photogrammetry.

    Science.gov (United States)

    Xin, Pengfei; Yu, Hongbo; Cheng, Huanchong; Shen, Shunyao; Shen, Steve G F

    2013-09-01

    The aim of this study was to demonstrate the feasibility of building a craniofacial virtual reality model by image fusion of 3-dimensional (3D) CT models and 3 dMD stereophotogrammetric facial surface. A CT scan and stereophotography were performed. The 3D CT models were reconstructed by Materialise Mimics software, and the stereophotogrammetric facial surface was reconstructed by 3 dMD patient software. All 3D CT models were exported as Stereo Lithography file format, and the 3 dMD model was exported as Virtual Reality Modeling Language file format. Image registration and fusion were performed in Mimics software. Genetic algorithm was used for precise image fusion alignment with minimum error. The 3D CT models and the 3 dMD stereophotogrammetric facial surface were finally merged into a single file and displayed using Deep Exploration software. Errors between the CT soft tissue model and 3 dMD facial surface were also analyzed. Virtual model based on CT-3 dMD image fusion clearly showed the photorealistic face and bone structures. Image registration errors in virtual face are mainly located in bilateral cheeks and eyeballs, and the errors are more than 1.5 mm. However, the image fusion of whole point cloud sets of CT and 3 dMD is acceptable with a minimum error that is less than 1 mm. The ease of use and high reliability of CT-3 dMD image fusion allows the 3D virtual head to be an accurate, realistic, and widespread tool, and has a great benefit to virtual face model.

  17. STRATEGI PEMASARAN PUBLIC RELATIONS MD ENTERTAINMENT PADA PEMASARAN FILM HABIBIE & AINUN

    OpenAIRE

    Trisna Adi Permana; Lilis Puspitasari

    2015-01-01

    Tujuan penelitian ini adalah untuk mengetahui perencanaan, implementasi serta evaluasi dari strategi Marketing Public Relations yang ditetapkan PR MD Entertainment pada film Habibie & Ainun pada tahun 2012-2013. Metode yang dilakukan adalah metode deskriptif yang bertujuan melukiskan secara sistematis fakta atau karakteristik populasi tertentu atau bidang tertentu secara faktual dan cermat. Hasil penelitian menunjukan PR MD Entertainment telah melakukan tahapan-tahapan atau Teknik...

  18. Strategi Pemasaran Public Relations Md Entertainment Pada Pemasaran Film Habibie & Ainun

    OpenAIRE

    Permana, Trisna Adi; Puspitasari, Lilis

    2015-01-01

    Tujuan penelitian ini adalah untuk mengetahui perencanaan, implementasi serta evaluasi dari strategiMarketing Public Relations yang ditetapkan PR MD Entertainment pada film Habibie & Ainun pada tahun2012-2013. Metode yang dilakukan adalah metode deskriptif yang bertujuan melukiskan secara sistematisfakta atau karakteristik populasi tertentu atau bidang tertentu secara faktual dan cermat. Hasil penelitianmenunjukan PR MD Entertainment telah melakukan tahapan-tahapan atau Teknik PR pada film Ha...

  19. Summary of LHC MD 369: DOROS vs WBTN in IR Stripline BPMs

    CERN Document Server

    Draskovic, Drasko; Calvo Giraldo, Eva; Olexa, Jakub; Gasior, Marek; CERN. Geneva. ATS Department

    2015-01-01

    The aim of this MD is to quantify the impact of the stripline beam position monitor (BPM) directivity with two acquisition chain electronics systems, WBTN (Wide Band Time Normalizer) and DOROS (Diode ORbit and Oscillation System). This impact depends on the relative position and intensity of the two beams at the location of the monitor. This note explains all the procedures of the LHC MD 369, which took place on 20/07/2015 and presents the obtained results.

  20. MdCOP1 Ubiquitin E3 Ligases Interact with MdMYB1 to Regulate Light-Induced Anthocyanin Biosynthesis and Red Fruit Coloration in Apple1[W][OA

    Science.gov (United States)

    Li, Yuan-Yuan; Mao, Ke; Zhao, Cheng; Zhao, Xian-Yan; Zhang, Hua-Lei; Shu, Huai-Rui; Hao, Yu-Jin

    2012-01-01

    MdMYB1 is a crucial regulator of light-induced anthocyanin biosynthesis and fruit coloration in apple (Malus domestica). In this study, it was found that MdMYB1 protein accumulated in the light but degraded via a ubiquitin-dependent pathway in the dark. Subsequently, the MdCOP1-1 and MdCOP1-2 genes were isolated from apple fruit peel and were functionally characterized in the Arabidopsis (Arabidopsis thaliana) cop1-4 mutant. Yeast (Saccharomyces cerevisiae) two-hybrid, bimolecular fluorescence complementation, and coimmunoprecipitation assays showed that MdMYB1 interacts with the MdCOP1 proteins. Furthermore, in vitro and in vivo experiments indicated that MdCOP1s are necessary for the ubiquitination and degradation of MdMYB1 protein in the dark and are therefore involved in the light-controlled stability of the MdMYB1 protein. Finally, a viral vector-based transformation approach demonstrated that MdCOP1s negatively regulate the peel coloration of apple fruits by modulating the degradation of the MdMYB1 protein. Our findings provide new insight into the mechanism by which light controls anthocyanin accumulation and red fruit coloration in apple and even other plant species. PMID:22855936

  1. Effect of salinity and temperature on treatment of concentrated wastewater from RO by FO-MD

    Science.gov (United States)

    Zhou, Yingru; Huang, Manhong; Deng, Qian

    2018-02-01

    In this study the appropriate temperature of the membrane distillation (MD) hot side (the permeation flux of MD was controlled by adjusting the hot side temperature) was selected according to the water flux of FO process so that the water transfer rate on both sides of FO and MD was consistent and the FO-MD process could be stable operation. When the salt concentration of feed solution was 30, 55, 80 and 100 g/L, the desalination rates changed little, which were 99.1%, 98.4%, 98.9% and 98.7%, respectively. The removal rate of COD was 93.8%, 94.2%, 91.6% and 92.7% which also changed little like the desalination rates. The removal rate of chromaticity increased with the increase of salinity, which attained 96.6%, 97.0%, 97.2% and 97.9%, respectively. This study proved that salinity of the feed solution affected little on the removal rate of contaminants but great on the water flux, with the increase of salinity from 30 to 100 g/L, the water flux was 6.05, 4.81, 4.33 and 3.87 LMH with the appropriate temperature (67.5±0.5, 64.5±0.5, 62.5±0.5 and 60.5±0.5 °C) of MD hot side. In a word, FO-MD was first used to treat the high salinity RO water with over 30 g/L total dissolved solids (TDS), FO-MD was a promising new process for high salinity wastewater treatment, and the hybrid system can solve the problem of lower draw solution concentration, and the high-quality production water will be obtained directly by this hybrid system with low membrane fouling tendency.

  2. Pengaruh Brand Ambassador Terhadap Minat Beli Konsumen MD Clinic By Lazeta

    Directory of Open Access Journals (Sweden)

    Nurvita Septya Ningrum

    2016-10-01

    Full Text Available This research at MD Clinic by Lazeta which is in the beauty services that offer health care and facial, under of PT. Medina Global Care. MD Cilinic by Lazeta use the brand ambassador of introducing their products. The selection of brand ambassador motivated by positive image brought by the celebrities. Brand ambassadors chosen by the company as a symbol or a marker to represent the wishes and needs of prospective customers. MD Clinic by Lazeta choose Syahnaz as a brand ambassador for their products which is expected to to represent the product of MD Clinic by Lazeta, so the message can be understood by the consumer, who eventually would to lead the purchase intention. The purpose of this research was to investigate the influence of brand ambassadors on consumer purchase intention MD Clinic by Lazeta, Study on Business Administration Students year in 2103 Telkom University. Researchers used quantitative research methods. This research is population research, because all population is being respondent in this research. Populations of this research are 137 respondents. Collecting data in this research is conducted by using questionnaire distributed to all respondents, which all Students on Business Administration Telkom University who knows the MD Clinic by Lazeta. Data were analyzed using simple regression analysis and descriptive analysis.The results showed that the Brand Ambassador impact of consumer purchase intention on MD Clinic by Lazeta at the Students on Business Administration Telkom University years in 2013. Based on the calculation of the coefficient of determination (R2 can be seen the influence of brand ambassador variable (X on purchase intention (Y is 42.9%. While the remaining 57.1% is influenced by other factors which not examined in this research such as, pricing, marketing strategy and others.

  3. The small ubiquitin-like modifier E3 ligase MdSIZ1 promotes anthocyanin accumulation by sumoylating MdMYB1 under low-temperature conditions in apple.

    Science.gov (United States)

    Zhou, Li-Jie; Li, Yuan-Yuan; Zhang, Rui-Fen; Zhang, Chun-Ling; Xie, Xing-Bin; Zhao, Cheng; Hao, Yu-Jin

    2017-10-01

    MdMYB1 acts as a crucial component of the MYB-bHLH-WD40 complex to regulate anthocyanin biosynthesis in red-skinned apples (Malus domestica), but little is known about its post-translational regulation. Here, a small ubiquitin-like modifier E3 ligase MdSIZ1 was screened out as an MdMYB1-interacting protein with a yeast two-hybridization approach. The interaction between MdSIZ1 and MdMYB1 was further verified with pull-down and CoIP assays. Furthermore, it was found that MdSIZ1 directly sumoylated MdMYB1 proteins in vivo and in vitro, especially under moderately low temperature (17 °C) conditions, and that this sumoylation was required for MdMYB1 protein stability. Moreover, the transcription level of MdSIZ1 gene was remarkably induced by low temperature and phosphorus deficiency, and MdSIZ1 overexpression exerted a large positive influence on anthocyanin accumulation and red fruit coloration, suggesting its important role in the regulation of anthocyanin biosynthesis under stress conditions. Our findings reveal an important role for a small ubiquitin-like modifier modification of MYB transcription factors in regulation of anthocyanin biosynthesis in plants. © 2017 John Wiley & Sons Ltd.

  4. The molecular mechanism underlying anthocyanin metabolism in apple using the MdMYB16 and MdbHLH33 genes.

    Science.gov (United States)

    Xu, Haifeng; Wang, Nan; Liu, Jingxuan; Qu, Changzhi; Wang, Yicheng; Jiang, Shenghui; Lu, Ninglin; Wang, Deyun; Zhang, Zongying; Chen, Xuesen

    2017-05-01

    MdMYB16 forms homodimers and directly inhibits anthocyanin synthesis via its C-terminal EAR repressor. It weakened the inhibitory effect of MdMYB16 on anthocyanin synthesis when overexpressing MdbHLH33 in callus overexpressing MdMYB16. MdMYB16 could interact with MdbHLH33. Anthocyanins are strong antioxidants that play a key role in the prevention of cardiovascular disease, cancer, and diabetes. The germplasm of Malus sieversii f. neidzwetzkyana is important for the study of anthocyanin metabolism. To date, only limited studies have examined the negative regulatory mechanisms underlying anthocyanin synthesis in apple. Here, we analyzed the relationship between anthocyanin levels and MdMYB16 expression in mature Red Crisp 1-5 apple (M. domestica) fruit, generated an evolutionary tree, and identified an EAR suppression sequence and a bHLH binding motif of the MdMYB16 protein using protein sequence analyses. Overexpression of MdMYB16 or MdMYB16 without bHLH binding sequence (LBSMdMYB16) in red-fleshed callus inhibited MdUFGT and MdANS expression and anthocyanin synthesis. However, overexpression of MdMYB16 without the EAR sequence (LESMdMYB16) in red-fleshed callus had no inhibitory effect on anthocyanin. The yeast one-hybrid assay showed that MdMYB16 and LESMdMYB16 interacted the promoters of MdANS and MdUFGT, respectively. Yeast two-hybrid, pull-down, and bimolecular fluorescence complementation assays showed that MdMYB16 formed homodimers and interacted with MdbHLH33, however, the LBSMdMYB16 could not interact with MdbHLH33. We overexpressed MdbHLH33 in callus overexpressing MdMYB16 and found that it weakened the inhibitory effect of MdMYB16 on anthocyanin synthesis. Together, these results suggested that MdMYB16 and MdbHLH33 may be important part of the regulatory network controlling the anthocyanin biosynthetic pathway.

  5. PuReMD-GPU: A reactive molecular dynamics simulation package for GPUs

    International Nuclear Information System (INIS)

    Kylasa, S.B.; Aktulga, H.M.; Grama, A.Y.

    2014-01-01

    We present an efficient and highly accurate GP-GPU implementation of our community code, PuReMD, for reactive molecular dynamics simulations using the ReaxFF force field. PuReMD and its incorporation into LAMMPS (Reax/C) is used by a large number of research groups worldwide for simulating diverse systems ranging from biomembranes to explosives (RDX) at atomistic level of detail. The sub-femtosecond time-steps associated with ReaxFF strongly motivate significant improvements to per-timestep simulation time through effective use of GPUs. This paper presents, in detail, the design and implementation of PuReMD-GPU, which enables ReaxFF simulations on GPUs, as well as various performance optimization techniques we developed to obtain high performance on state-of-the-art hardware. Comprehensive experiments on model systems (bulk water and amorphous silica) are presented to quantify the performance improvements achieved by PuReMD-GPU and to verify its accuracy. In particular, our experiments show up to 16× improvement in runtime compared to our highly optimized CPU-only single-core ReaxFF implementation. PuReMD-GPU is a unique production code, and is currently available on request from the authors

  6. PuReMD-GPU: A reactive molecular dynamics simulation package for GPUs

    Energy Technology Data Exchange (ETDEWEB)

    Kylasa, S.B., E-mail: skylasa@purdue.edu [Department of Elec. and Comp. Eng., Purdue University, West Lafayette, IN 47907 (United States); Aktulga, H.M., E-mail: hmaktulga@lbl.gov [Lawrence Berkeley National Laboratory, 1 Cyclotron Rd, MS 50F-1650, Berkeley, CA 94720 (United States); Grama, A.Y., E-mail: ayg@cs.purdue.edu [Department of Computer Science, Purdue University, West Lafayette, IN 47907 (United States)

    2014-09-01

    We present an efficient and highly accurate GP-GPU implementation of our community code, PuReMD, for reactive molecular dynamics simulations using the ReaxFF force field. PuReMD and its incorporation into LAMMPS (Reax/C) is used by a large number of research groups worldwide for simulating diverse systems ranging from biomembranes to explosives (RDX) at atomistic level of detail. The sub-femtosecond time-steps associated with ReaxFF strongly motivate significant improvements to per-timestep simulation time through effective use of GPUs. This paper presents, in detail, the design and implementation of PuReMD-GPU, which enables ReaxFF simulations on GPUs, as well as various performance optimization techniques we developed to obtain high performance on state-of-the-art hardware. Comprehensive experiments on model systems (bulk water and amorphous silica) are presented to quantify the performance improvements achieved by PuReMD-GPU and to verify its accuracy. In particular, our experiments show up to 16× improvement in runtime compared to our highly optimized CPU-only single-core ReaxFF implementation. PuReMD-GPU is a unique production code, and is currently available on request from the authors.

  7. [MD PhD programs: Providing basic science education for ophthalmologists].

    Science.gov (United States)

    Spaniol, K; Geerling, G

    2015-06-01

    Enrollment in MD PhD programs offers the opportunity of a basic science education for medical students and doctors. These programs originated in the USA where structured programs have been offered for many years, but now German universities also run MD PhD programs. The MD PhD programs provided by German universities were investigated regarding entrance requirements, structure and financing modalities. An internet and telephone-based search was carried out. Out of 34 German universities 22 offered MD PhD programs. At 15 of the 22 universities a successfully completed course of studies in medicine was required for enrollment, 7 programs admitted medical students in training and 7 programs required a medical doctoral thesis, which had to be completed with at least a grade of magna cum laude in 3 cases. Financing required scholarships in many cases. Several German universities currently offer MD PhD programs; however, these differ considerably regarding entrance requirements, structure and financing. A detailed analysis investigating the success rates of these programs (e.g. successful completion and career paths of graduates) would be of benefit.

  8. Opinion of stakeholders on existing curriculum for postgraduate (MD) course in Pharmacology: A survey.

    Science.gov (United States)

    Badyal, Dinesh K; Daniel, Sujit R

    2016-10-01

    To survey the opinion about various curricular components of Doctor of Medicine (MD) pharmacology curriculum in India by stakeholders, including faculty and students. An online survey was done to evaluate the various curricular components of MD pharmacology curriculum being used in India. A total of 393 respondents including faculty, MD students, and other stakeholders completed the survey. The survey was developed using SurveyMonkey platform and link to survey was E-mailed to stakeholders. The results were expressed as percentages. There was a balanced representation of respondents from various designations, teaching experience, regions, and age groups. Most of the respondents (83%) were aware of the MD pharmacology curriculum. However, they reported that it is more inclined to knowledge domain. About half of respondents (53%) said that animal experiments are being used. The most common teaching methods mentioned are seminars (98.5%), journal clubs (95%), and practical exercises by postgraduates (73%), but there is less use of newer methods (25%) in theory and less of clinical pharmacology exercise (39%) in practical classes. The log books are maintained but not assessed regularly. Internal assessment is sparingly used. The MD pharmacology curriculum needs to be made uniform at the national level and updated to include the newer methods in teaching-learning and assessment. There should be sharing of newer methods at a common platform implemented at the national level.

  9. An unusual dimeric structure and assembly for TLR4 regulator RP105-MD-1

    Energy Technology Data Exchange (ETDEWEB)

    Yoon, Sung-il; Hong, Minsun; Wilson, Ian A [Scripps

    2011-11-16

    RP105-MD-1 modulates the TLR4-MD-2-mediated, innate immune response against bacterial lipopolysaccharide (LPS). The crystal structure of the bovine 1:1 RP105-MD-1 complex bound to a putative endogenous lipid at 2.9 Å resolution shares a similar overall architecture to its homolog TLR4-MD-2 but assembles into an unusual 2:2 homodimer that differs from any other known TLR-ligand assembly. The homodimer is assembled in a head-to-head orientation that juxtaposes the N-terminal leucine-rich repeats (LRRs) of the two RP105 chains, rather than the usual tail-to-tail configuration of C-terminal LRRs in ligand-activated TLR dimers, such as TLR1-TRL2, TLR2-TLR6, TLR3-TLR3 and TLR4-TLR4. Another unusual interaction is mediated by an RP105-specific asparagine-linked glycan, which wedges MD-1 into the co-receptor binding concavity on RP105. This unique mode of assembly represents a new paradigm for TLR complexes and suggests a molecular mechanism for regulating LPS responses.

  10. Crystal twinning of human MD-2 recognizing endotoxin cores of lipopolysaccharide

    International Nuclear Information System (INIS)

    Ohto, Umeharu; Satow, Yoshinori

    2008-01-01

    Twinned crystals of humaan MD-2 are transformed into single crystals with cryoprotectant optimization. Twinning of crystals causes overlapping of two or more reciprocal lattice points, and hence structure amplitudes for a single crystalline domain are hardly obtained from X-ray diffraction intensities. MD-2 protein forms a stable complex with Toll-like receptor 4 and recognizes bacterial lipopolysaccharide (LPS). Excessive immune responses activated by LPS cause septic shocks. Saccharide-trimmed human MD-2 crystallizes in the tetragonal form with apparent Laue symmetry of 4/mmm, and diffraction intensities from these crystals indicate crystal twinning. The crystal consists of two different domains, A and B. The c A axis of domain A coincides with the c B axis of domain B with a smaller lattice, and the a A axis corresponds to the (a B + b B ) axis. This twinning severely imposes difficulty in structure determination. Through optimization of cryoprotectant, domain A was thoroughly transformed into domain B. The crystal containing only domain B is in space group P4 1 2 1 2 with one MD-2 molecule in the asymmetric unit. The structure of this form of MD-2 as well as its complex with antiendotoxic lipid IVa was successfully determined using the multiple isomorphous replacement method

  11. MD and BCA simulations of He and H bombardment of fuzz in bcc elements

    Science.gov (United States)

    Klaver, T. P. C.; Zhang, S.; Nordlund, K.

    2017-08-01

    We present results of MD simulations of low energy He ion bombardment of low density fuzz in bcc elements. He ions can penetrate several micrometers into sparse fuzz, which allows for a sufficient He flux through it to grow the fuzz further. He kinetic energy falls off exponentially with penetration depth. A BCA code was used to carry out the same ion bombardment on the same fuzz structures as in MD simulations, but with simpler, 10 million times faster calculations. Despite the poor theoretical basis of the BCA at low ion energies, and the use of somewhat different potentials in MD and BCA calculations, the ion penetration depths predicted by BCA are only ∼12% less than those predicted by MD. The MD-BCA differences are highly systematic and trends in the results of the two methods are very similar. We have carried out more than 200 BCA calculation runs of ion bombardment of fuzz, in which parameters in the ion bombardment process were varied. For most parameters, the results show that the ion bombardment process is quite generic. The ion species (He or H), ion mass, fuzz element (W, Ta, Mo, Fe) and fuzz element lattice parameter turned out to have a modest influence on ion penetration depths at most. An off-normal angle of incidence strongly reduces the ion penetration depth. Increasing the ion energy increases the ion penetration, but the rate by which ion energy drops off at high ion energies follows the same exponential pattern as at lower energies.

  12. Center of excellence for mobile sensor data-to-knowledge (MD2K).

    Science.gov (United States)

    Kumar, Santosh; Abowd, Gregory D; Abraham, William T; al'Absi, Mustafa; Beck, J Gayle; Chau, Duen Horng; Condie, Tyson; Conroy, David E; Ertin, Emre; Estrin, Deborah; Ganesan, Deepak; Lam, Cho; Marlin, Benjamin; Marsh, Clay B; Murphy, Susan A; Nahum-Shani, Inbal; Patrick, Kevin; Rehg, James M; Sharmin, Moushumi; Shetty, Vivek; Sim, Ida; Spring, Bonnie; Srivastava, Mani; Wetter, David W

    2015-11-01

    Mobile sensor data-to-knowledge (MD2K) was chosen as one of 11 Big Data Centers of Excellence by the National Institutes of Health, as part of its Big Data-to-Knowledge initiative. MD2K is developing innovative tools to streamline the collection, integration, management, visualization, analysis, and interpretation of health data generated by mobile and wearable sensors. The goal of the big data solutions being developed by MD2K is to reliably quantify physical, biological, behavioral, social, and environmental factors that contribute to health and disease risk. The research conducted by MD2K is targeted at improving health through early detection of adverse health events and by facilitating prevention. MD2K will make its tools, software, and training materials widely available and will also organize workshops and seminars to encourage their use by researchers and clinicians. © The Author 2015. Published by Oxford University Press on behalf of the American Medical Informatics Association. All rights reserved. For Permissions, please email: journals.permissions@oup.com.

  13. Evaluation of hydroacid complex in the forward osmosis–membrane distillation (FO–MD) system for desalination

    KAUST Repository

    Wang, Peng; Cui, Yue; Ge, Qingchun; Fern Tew, Tjin; Chung, Neal Tai-Shung

    2015-01-01

    The incorporation of membrane distillation (MD) into forward osmosis (FO) provides process sustainability to regenerate the draw solution and to produce clean water simultaneously. However, the reverse salt flux is the major hurdle in the FO-MD system because it not only reduces the effective osmotic driving force across the membrane but also increases the replenishment cost and scaling issue. For the first time, a hydroacid complex with abundant hydrophilic groups and ionic species is evaluated as the draw solutes in the hybrid FO-MD system consisting of multi-bore PVDF MD membranes for seawater/brackish desalination. In order to evaluate the practicality of the hydroacid complex in the FO-MD system, FO and MD experiments were conducted at elevated temperatures and concentrations. The hydroacid complex has displayed desired properties such as high solubility, low viscosity, excellent thermal stability and minimal reverse salt flux suitable for FO and MD operations. FO-MD desalination process was demonstrated with a highest seawater desalination flux of 6/32 LMH (FO/MD). This study may open up the prospective of employing the hydroacid complex as the draw solute in FO-MD hybrid systems for seawater /brackish desalination. © 2015 Elsevier B.V.

  14. Angiotensin II induces kidney inflammatory injury and fibrosis through binding to myeloid differentiation protein-2 (MD2).

    Science.gov (United States)

    Xu, Zheng; Li, Weixin; Han, Jibo; Zou, Chunpeng; Huang, Weijian; Yu, Weihui; Shan, Xiaoou; Lum, Hazel; Li, Xiaokun; Liang, Guang

    2017-03-21

    Growing evidence indicates that angiotensin II (Ang II), a potent biologically active product of RAS, is a key regulator of renal inflammation and fibrosis. In this study, we tested the hypothesis that Ang II induces renal inflammatory injury and fibrosis through interaction with myeloid differentiation protein-2 (MD2), the accessory protein of toll-like receptor 4 (TLR4) of the immune system. Results indicated that in MD2 -/- mice, the Ang II-induced renal fibrosis, inflammation and kidney dysfunction were significantly reduced compared to control Ang II-infused wild-type mice. Similarly, in the presence of small molecule MD2 specific inhibitor L6H21 or siRNA-MD2, the Ang II-induced increases of pro-fibrotic and pro-inflammatory molecules were prevented in tubular NRK-52E cells. MD2 blockade also inhibited activation of NF-κB and ERK. Moreover, MD2 blockade prevented the Ang II-stimulated formation of the MD2/TLR4/MyD88 signaling complex, as well as the increased surface binding of Ang II in NRK-52E cells. In addition, Ang II directly bound recombinant MD2 protein, rather than TLR4 protein. We conclude that MD2 is a significant contributor in the Ang II-induced kidney inflammatory injury in chronic renal diseases. Furthermore, MD2 inhibition could be a new and important therapeutic strategy for preventing progression of chronic renal diseases.

  15. Evaluation of hydroacid complex in the forward osmosis–membrane distillation (FO–MD) system for desalination

    KAUST Repository

    Wang, Peng

    2015-11-01

    The incorporation of membrane distillation (MD) into forward osmosis (FO) provides process sustainability to regenerate the draw solution and to produce clean water simultaneously. However, the reverse salt flux is the major hurdle in the FO-MD system because it not only reduces the effective osmotic driving force across the membrane but also increases the replenishment cost and scaling issue. For the first time, a hydroacid complex with abundant hydrophilic groups and ionic species is evaluated as the draw solutes in the hybrid FO-MD system consisting of multi-bore PVDF MD membranes for seawater/brackish desalination. In order to evaluate the practicality of the hydroacid complex in the FO-MD system, FO and MD experiments were conducted at elevated temperatures and concentrations. The hydroacid complex has displayed desired properties such as high solubility, low viscosity, excellent thermal stability and minimal reverse salt flux suitable for FO and MD operations. FO-MD desalination process was demonstrated with a highest seawater desalination flux of 6/32 LMH (FO/MD). This study may open up the prospective of employing the hydroacid complex as the draw solute in FO-MD hybrid systems for seawater /brackish desalination. © 2015 Elsevier B.V.

  16. MdHB1 down-regulation activates anthocyanin biosynthesis in the white-fleshed apple cultivar 'Granny Smith'.

    Science.gov (United States)

    Jiang, Yonghua; Liu, Cuihua; Yan, Dan; Wen, Xiaohong; Liu, Yanli; Wang, Haojie; Dai, Jieyu; Zhang, Yujie; Liu, Yanfei; Zhou, Bin; Ren, Xiaolin

    2017-02-01

    Coloration in apple (Malus×domestica) flesh is mainly caused by the accumulation of anthocyanin. Anthocyanin is biosynthesized through the flavonoid pathway and regulated by MYB, bHLH, and WD40 transcription factors (TFs). Here, we report that the HD-Zip I TF MdHB1 was also involved in the regulation of anthocyanin accumulation. MdHB1 silencing caused the accumulation of anthocyanin in 'Granny Smith' flesh, whereas its overexpression reduced the flesh content of anthocyanin in 'Ballerina' (red-fleshed apple). Moreover, flowers of transgenic tobacco (Nicotiana tabacum 'NC89') overexpressing MdHB1 showed a remarkable reduction in pigmentation. Transient promoter activation assays and yeast one-hybrid results indicated that MdHB1 indirectly inhibited expression of the anthocyanin biosynthetic genes encoding dihydroflavonol-4-reductase (DFR) and UDP-glucose:flavonoid 3-O-glycosyltransferase (UFGT). Yeast two-hybrid and bimolecular fluorescence complementation determined that MdHB1 acted as a homodimer and could interact with MYB, bHLH, and WD40 in the cytoplasm, consistent with its cytoplasmic localization by green fluorescent protein fluorescence observations. Together, these results suggest that MdHB1 constrains MdMYB10, MdbHLH3, and MdTTG1 to the cytoplasm, and then represses the transcription of MdDFR and MdUFGT indirectly. When MdHB1 is silenced, these TFs are released to activate the expression of MdDFR and MdUFGT and also anthocyanin biosynthesis, resulting in red flesh in 'Granny Smith'. © The Author 2017. Published by Oxford University Press on behalf of the Society for Experimental Biology. All rights reserved. For permissions, please email: journals.permissions@oup.com.

  17. Combination of advanced encryption standard 256 bits with md5 to secure documents on android smartphone

    Science.gov (United States)

    Pasaribu, Hendra; Sitanggang, Delima; Rizki Damanik, Rudolfo; Rudianto Sitompul, Alex Chandra

    2018-04-01

    File transfer by using a smartphone has some security issues like data theft by irresponsible parties. To improve the quality of data security systems on smartphones, in this research the integration of AES 256 bit algorithm by using MD5 hashing is proposed. The use of MD5 aims to increase the key strength of the encryption and decryption process of document files. The test results show that the proposed method can increase the key strength of the encryption and decryption process in the document file. Encryption and decryption time by using AES and MD5 combination is faster than using AES only on *.txt file type and reverse results for *.docx, *.xlsx, *.pptx and *.pdf file files.

  18. MD1271: Effect of low frequency noise on the evolution of the emittance and halo population

    CERN Document Server

    Fitterer, Miriam; Valishev, Alexander; Bruce, Roderik; Hofle, Wolfgang; Hostettler, Michi; Papadopoulou, Parthena Stefania; Papotti, Giulia; Papaphilippou, Yannis; Pellegrini, Dario; Trad, Georges; Valuch, Daniel; Valentino, Gianluca; Wagner, Joschka; Cai, Xu; CERN. Geneva. ATS Department

    2018-01-01

    For the High Luminosity upgrade the β* in IR1 and IR5 will be further reduced compared to the current LHC. As the β* decreases the β-functions in the inner triplet (IT) increase resulting in a higher sensitivity of the HL-LHC to ground motion in the IT region or to increases of the low frequency noise. Noise can in general lead to emittance growth and higher halo population and diffusion rate. However, it is usually assumed in the literature that only frequencies close to the betatron frequencies and sidebands have an effect on the emittance and tail population. To test this theory, an MD was carried out to observe if also low frequency noise can lead to emittance growth and stronger halo population and diffusion. This MD conducted on 24.08.2016 follows a previous MD on 05.11.2015/06.11.2015

  19. Measuring fN force variations in the presence of constant nN forces: a torsion pendulum ground test of the LISA Pathfinder free-fall mode

    Science.gov (United States)

    Russano, G.; Cavalleri, A.; Cesarini, A.; Dolesi, R.; Ferroni, V.; Gibert, F.; Giusteri, R.; Hueller, M.; Liu, L.; Pivato, P.; Tu, H. B.; Vetrugno, D.; Vitale, S.; Weber, W. J.

    2018-02-01

    LISA Pathfinder is a differential accelerometer with the main goal being to demonstrate the near perfect free-fall of reference test masses, as is needed for an orbiting gravitational wave observatory, with a target sensitivity of 30 fm s‑2 Hz-1/2 at 1 mHz. Any lasting background differential acceleration between the two test masses must be actively compensated, and noise associated with the applied actuation force can be a dominant source of noise. To remove this actuation, and the associated force noise, a ‘free-fall’ actuation control scheme has been designed; actuation is limited to brief impulses, with both test masses in free-fall in the time between the impulses, allowing measurement of the remaining acceleration noise sources. In this work, we present an on-ground torsion pendulum testing campaign of this technique and associated data analysis algorithms at a level nearing the sub-femto-g/\\sqrtHz performance required for LISA Pathfinder.

  20. A high sensitivity heterodyne interferometer as a possible optical readout for the LISA gravitational reference sensor and its application to technology verification

    Energy Technology Data Exchange (ETDEWEB)

    Gohlke, Martin; Weise, Dennis; Johann, Ulrich; Braxmaier, Claus [EADS Astrium, Claude-Dornier-Strasse, 88039 Friedrichshafen (Germany); Schuldt, Thilo; Peters, Achim, E-mail: martin.gohlke@astrium.eads.ne [Humboldt-Universitaet zu Berlin, Hausvogteiplatz 5-7, 10117 Berlin (Germany)

    2009-03-01

    The space-based gravitational wave detector LISA (Laser Interferometer Space Antenna) utilizes a high performance position sensor in order to measure the translation and tilt of the free flying proof mass with respect to the optical bench. Depending on the LISA optical bench design, this position sensor must have up to pm/sq rootHz sensitivity for the translation measurement and up to nrad/sq rootHz sensitivity for the tilt measurement. We developed a heterodyne interferometer, combined with differential wavefront sensing, for the tilt measurement. The interferometer design exhibits maximum symmetry where measurement and reference arm have the same frequency and polarization and the same optical path-lengths. The interferometer can be set up free of polarizing optical components preventing possible problems with thermal dependencies not suitable for the space environment. We developed a mechanically highly stable and compact setup which is located in a vacuum chamber. We measured initial noise levels below 10 pm/sq rootHz (longitudinal measurement) for frequencies above 10 mHz and below 20 nrad/sq rootHz (tilt measurement) for frequencies above 1 mHz. This setup can also be used for other applications, for example the measurement of the coefficient of thermal expansion (CTE) of structural materials, such as carbon fiber reinforced plastic (CFRP).

  1. MD/MBA programs in the United States: evidence of a change in health care leadership.

    Science.gov (United States)

    Larson, David B; Chandler, Maria; Forman, Howard P

    2003-03-01

    Managerial sciences are playing an increasingly prominent role in the organization and delivery of health care. Despite popular media reports that a rising number of physicians are acquiring a background in this discipline through MD/MBA (medical and master of business administration) programs, no recent study has verified this. This study measured changes in the number and nature of the affiliations between management and medicine in the form of MD/MBA programs in the United States. Surveys of admission officers of 125 U.S. allopathic medical schools and of the overseers of each joint MD/MBA degree program were administered in May-October 2001. Main outcome measures included program growth, curriculum and degree requirements, application and admission requirements, and program leadership and organization. The number of MD/MBA programs grew from six to 33 between 1993 and 2001, and 17 more medical schools were considering establishing the joint-degree program. Ten, 15, and 20 programs produced 27, 42, and 61 graduates in 1999, 2000, and 2001, respectively, and over 100 students were expected to graduate per year when all 33 programs matured. Program structures and oversight indicate a spectrum of philosophies regarding the appropriate level of integration of the two degrees. MD/MBA programs apparently attempt to complement medical education with management education rather than the converse. The growth in the numbers of MD/MBA programs and participants indicates rising cooperation between medical and business schools and increasing interest in management education early in the careers of graduating physicians.

  2. The AINTEGUMENTA genes, MdANT1 and MdANT2, are associated with the regulation of cell production during fruit growth in apple (Malus × domestica Borkh.).

    Science.gov (United States)

    Dash, Madhumita; Malladi, Anish

    2012-06-25

    Fruit growth in apple (Malus × domestica Borkh.) is mediated by cell production and expansion. Genes involved in regulating these processes and thereby fruit growth, are not well characterized. We hypothesized that the apple homolog(s) of AINTEGUMENTA (ANT), an APETALA2-repeat containing transcription factor, regulates cell production during fruit growth in apple. Two ANT genes, MdANT1 and MdANT2, were isolated from apple and their expression was studied during multiple stages of fruit development. MdANT1 and MdANT2 expression was high during early fruit growth coincident with the period of cell production, rapidly declined during exit from cell production, and remained low during the rest of fruit development. The effects of increase in carbohydrate availability during fruit growth were characterized. Increase in carbohydrate availability enhanced fruit growth largely through an increase in cell production. Expression of MdANT1 and MdANT2 increased sharply by up to around 5-fold in response to an increase in carbohydrate availability. Expression of the ANT genes was compared across two apple genotypes, 'Gala' and 'Golden Delicious Smoothee' (GS), which differ in the extent of fruit growth, largely due to differences in cell production. In comparison to 'Gala', the larger fruit-size genotype, GS, displayed higher levels and a longer duration of MdANT1 and MdANT2 expression. Expression of the ANTs and cell cycle genes in the fruit core and cortex tissues isolated using laser capture microdissection was studied. During early fruit growth, expression of the MdANTs was higher within the cortex, the tissue that constitutes the majority of the fruit. Additionally, MdANT1 and MdANT2 expression was positively correlated with that of A- and B-type CYCLINS, B-type CYCLIN-DEPENDENT-KINASES (CDKBs) and MdDEL1. Multiple lines of evidence from this study suggest that MdANT1 and MdANT2 regulate cell production during fruit growth in apple. ANTs may coordinate the expression of

  3. Molecular cloning and functional analysis of a blue light receptor gene MdCRY2 from apple (Malus domestica).

    Science.gov (United States)

    Li, Yuan-Yuan; Mao, Ke; Zhao, Cheng; Zhao, Xian-Yan; Zhang, Rui-Fen; Zhang, Hua-Lei; Shu, Huai-Rui; Hao, Yu-Jin

    2013-04-01

    MdCRY2 was isolated from apple fruit skin, and its function was analyzed in MdCRY2 transgenic Arabidopsis. The interaction between MdCRY2 and AtCOP1 was found by yeast two-hybrid and BiFC assays. Cryptochromes are blue/ultraviolet-A (UV-A) light receptors involved in regulating various aspects of plant growth and development. Investigations of the structure and functions of cryptochromes in plants have largely focused on Arabidopsis (Arabidopsis thaliana), tomato (Solanum lycopersicum), pea (Pisum sativum), and rice (Oryza sativa). However, no data on the function of CRY2 are available in woody plants. In this study, we isolated a cryptochrome gene, MdCRY2, from apple (Malus domestica). The deduced amino acid sequences of MdCRY2 contain the conserved N-terminal photolyase-related domain and the flavin adenine dinucleotide (FAD) binding domain, as well as the C-terminal DQXVP-acidic-STAES (DAS) domain. Relationship analysis indicates that MdCRY2 shows the highest similarity to the strawberry FvCRY protein. The expression of MdCRY2 is induced by blue/UV-A light, which represents a 48-h circadian rhythm. To investigate the function of MdCRY2, we overexpressed the MdCRY2 gene in a cry2 mutant and wild type (WT) Arabidopsis, assessed the phenotypes of the resulting transgenic plants, and found that MdCRY2 functions to regulate hypocotyl elongation, root growth, flower initiation, and anthocyanin accumulation. Furthermore, we examined the interaction between MdCRY2 and AtCOP1 using a yeast two-hybrid assay and a bimolecular fluorescence complementation assay. These data provide functional evidence for a role of blue/UV-A light-induced MdCRY2 in controlling photomorphogenesis in apple.

  4. Overexpression of a repressor MdMYB15L negatively regulates anthocyanin and cold tolerance in red-fleshed callus.

    Science.gov (United States)

    Xu, Haifeng; Yang, Guanxian; Zhang, Jing; Wang, Yicheng; Zhang, Tianliang; Wang, Nan; Jiang, Shenghui; Zhang, Zongying; Chen, Xuesen

    2018-04-14

    The cold-induced metabolic pathway and anthocyanin biosynthesis play important roles in plant growth. In this study, we identified a bHLH binding motif in the MdMYB15L protein using protein sequence analyses. Yeast two-hybrid and pull-down assays showed that MdMYB15L could interact with MdbHLH33. Overexpressing MdMYB15L in red-fleshed callus inhibited the expression of MdCBF2 and resulted in reduced cold tolerance but did not affect anthocyanin levels. Chip-PCR and EMSA analysis showed that MdMYB15L could bind the type II cis-acting element found in the MdCBF2 promoter. Overexpressing MdMYB15L in red-fleshed callus overexpressing MdbHLH33 also reduced cold tolerance and reduced MdbHLH33-induced anthocyanin biosynthesis. Knocking out the bHLH binding sequence of MdMYB15L (LBSMdMYB15L) prevented LBSMdMYB15L from interacting with MdbHLH33. Overexpressing LBSMdMYB15L in red-fleshed callus overexpressing MdbHLH33 also reduced cold tolerance and reduced MdbHLH33-induced anthocyanin biosynthesis. Together, these results suggested that an apple repressor MdMYB15L might play a key role in the cold signaling and anthocyanin metabolic pathways. Copyright © 2018 Elsevier Inc. All rights reserved.

  5. Humanized TLR4/MD-2 mice reveal LPS recognition differentially impacts susceptibility to Yersinia pestis and Salmonella enterica.

    Directory of Open Access Journals (Sweden)

    Adeline M Hajjar

    Full Text Available Although lipopolysaccharide (LPS stimulation through the Toll-like receptor (TLR-4/MD-2 receptor complex activates host defense against Gram-negative bacterial pathogens, how species-specific differences in LPS recognition impact host defense remains undefined. Herein, we establish how temperature dependent shifts in the lipid A of Yersinia pestis LPS that differentially impact recognition by mouse versus human TLR4/MD-2 dictate infection susceptibility. When grown at 37°C, Y. pestis LPS is hypo-acylated and less stimulatory to human compared with murine TLR4/MD-2. By contrast, when grown at reduced temperatures, Y. pestis LPS is more acylated, and stimulates cells equally via human and mouse TLR4/MD-2. To investigate how these temperature dependent shifts in LPS impact infection susceptibility, transgenic mice expressing human rather than mouse TLR4/MD-2 were generated. We found the increased susceptibility to Y. pestis for "humanized" TLR4/MD-2 mice directly paralleled blunted inflammatory cytokine production in response to stimulation with purified LPS. By contrast, for other Gram-negative pathogens with highly acylated lipid A including Salmonella enterica or Escherichia coli, infection susceptibility and the response after stimulation with LPS were indistinguishable between mice expressing human or mouse TLR4/MD-2. Thus, Y. pestis exploits temperature-dependent shifts in LPS acylation to selectively evade recognition by human TLR4/MD-2 uncovered with "humanized" TLR4/MD-2 transgenic mice.

  6. Humanized TLR4/MD-2 mice reveal LPS recognition differentially impacts susceptibility to Yersinia pestis and Salmonella enterica.

    Science.gov (United States)

    Hajjar, Adeline M; Ernst, Robert K; Fortuno, Edgardo S; Brasfield, Alicia S; Yam, Cathy S; Newlon, Lindsay A; Kollmann, Tobias R; Miller, Samuel I; Wilson, Christopher B

    2012-01-01

    Although lipopolysaccharide (LPS) stimulation through the Toll-like receptor (TLR)-4/MD-2 receptor complex activates host defense against Gram-negative bacterial pathogens, how species-specific differences in LPS recognition impact host defense remains undefined. Herein, we establish how temperature dependent shifts in the lipid A of Yersinia pestis LPS that differentially impact recognition by mouse versus human TLR4/MD-2 dictate infection susceptibility. When grown at 37°C, Y. pestis LPS is hypo-acylated and less stimulatory to human compared with murine TLR4/MD-2. By contrast, when grown at reduced temperatures, Y. pestis LPS is more acylated, and stimulates cells equally via human and mouse TLR4/MD-2. To investigate how these temperature dependent shifts in LPS impact infection susceptibility, transgenic mice expressing human rather than mouse TLR4/MD-2 were generated. We found the increased susceptibility to Y. pestis for "humanized" TLR4/MD-2 mice directly paralleled blunted inflammatory cytokine production in response to stimulation with purified LPS. By contrast, for other Gram-negative pathogens with highly acylated lipid A including Salmonella enterica or Escherichia coli, infection susceptibility and the response after stimulation with LPS were indistinguishable between mice expressing human or mouse TLR4/MD-2. Thus, Y. pestis exploits temperature-dependent shifts in LPS acylation to selectively evade recognition by human TLR4/MD-2 uncovered with "humanized" TLR4/MD-2 transgenic mice.

  7. MdATG18a overexpression improves tolerance to nitrogen deficiency and regulates anthocyanin accumulation through increased autophagy in transgenic apple.

    Science.gov (United States)

    Sun, Xun; Jia, Xin; Huo, Liuqing; Che, Runmin; Gong, Xiaoqing; Wang, Ping; Ma, Fengwang

    2018-02-01

    Nitrogen (N) availability is an essential factor for plant growth. Recycling and remobilization of N have strong impacts on crop yield and quality under N deficiency. Autophagy is a critical nutrient-recycling process that facilitates remobilization under starvation. We previously showed that an important AuTophaGy (ATG) protein from apple, MdATG18a, has a positive role in drought tolerance. In this study, we explored its biological role in response to low-N. Overexpression of MdATG18a in both Arabidopsis and apple improved tolerance to N-depletion and caused a greater accumulation of anthocyanin. The increased anthocyanin concentration in transgenic apple was possibly due to up-regulating flavonoid biosynthetic and regulatory genes (MdCHI, MdCHS, MdANS, MdPAL, MdUFGT, and MdMYB1) and higher soluble sugars concentration. MdATG18a overexpression enhanced starch degradation with up-regulating amylase gene (MdAM1) and up-regulated sugar metabolism related genes (MdSS1, MdHXKs, MdFK1, and MdNINVs). Furthermore, MdATG18a functioned in nitrate uptake and assimilation by up-regulating nitrate reductase MdNIA2 and 3 high-affinity nitrate transporters MdNRT2.1/2.4/2.5. MdATG18a overexpression also elevated other important MdATG genes expression and autophagosomes formation under N-depletion, which play key contributions to above changes. Together, these results demonstrate that overexpression of MdATG18a enhances tolerance to N-deficiencies and plays positive roles in anthocyanin biosynthesis through greater autophagic activity. © 2017 John Wiley & Sons Ltd.

  8. 76 FR 20008 - Notice of Temporary Concession Contract for Assateague Island National Seashore, MD

    Science.gov (United States)

    2011-04-11

    ... pre-packaged food and beverage. This action is necessary to avoid interruption of visitor services... DEPARTMENT OF THE INTERIOR National Park Service [NPS-WASO-CONC-0111-6544; 2410-OYC] Notice of Temporary Concession Contract for Assateague Island National Seashore, MD AGENCY: National Park Service...

  9. Property values, parks, and crime: a hedonic analysis in Baltimore, MD

    Science.gov (United States)

    Austin Troy; J. Morgan Grove

    2008-01-01

    While urban parks are generally considered to be a positive amenity, past research suggests that some parks are perceived as a neighborhood liability. Using hedonic analysis of property data in Baltimore, MD, we attempted to determine whether crime rate mediates how parks are valued by the housing market. Transacted price was regressed against park proximity, area-...

  10. 77 FR 42179 - Safety Zone; Fireworks Display, Potomac River, Charles County, Newburg, MD

    Science.gov (United States)

    2012-07-18

    ...]30[sec] W, located at Newburg in Charles County, Maryland (NAD 1983). The temporary safety zone will... 1625-AA00 Safety Zone; Fireworks Display, Potomac River, Charles County, Newburg, MD AGENCY: Coast Guard, DHS. ACTION: Temporary final rule. SUMMARY: The Coast Guard will establish a safety zone upon...

  11. 75 FR 18778 - Safety Zone; Ocean City Air Show 2010, Atlantic Ocean, Ocean City, MD

    Science.gov (United States)

    2010-04-13

    ...-AA00 Safety Zone; Ocean City Air Show 2010, Atlantic Ocean, Ocean City, MD AGENCY: Coast Guard, DHS... zone on the Atlantic Ocean in the vicinity of Ocean City, Maryland to support the Ocean City Air Show. This action is intended to restrict vessel traffic movement on the Atlantic Ocean to protect mariners...

  12. 75 FR 50878 - Airworthiness Directives; McDonnell Douglas Corporation Model MD-90-30 Airplanes

    Science.gov (United States)

    2010-08-18

    ... Airworthiness Directives; McDonnell Douglas Corporation Model MD- 90-30 Airplanes AGENCY: Federal Aviation... McDonnell Douglas Corporation: Amendment 39-16388. Docket No. FAA-2010-0433; Directorate Identifier 2009-NM..., 2010. Affected ADs (b) None. Applicability (c) This AD applies to McDonnell Douglas Corporation Model...

  13. 75 FR 68245 - Airworthiness Directives; McDonnell Douglas Corporation Model MD-90-30 Airplanes

    Science.gov (United States)

    2010-11-05

    ...-1043; Directorate Identifier 2010-NM-200-AD] RIN 2120-AA64 Airworthiness Directives; McDonnell Douglas... McDonnell Douglas Model MD-90-30 airplanes. This proposed AD would require installing new fire handle... airworthiness directive (AD): McDonnell Douglas Corporation: Docket No. FAA-2010-1043; Directorate Identifier...

  14. 75 FR 38056 - Airworthiness Directives; McDonnell Douglas Corporation Model MD-90-30 Airplanes

    Science.gov (United States)

    2010-07-01

    ...-0645; Directorate Identifier 2009-NM-200-AD] RIN 2120-AA64 Airworthiness Directives; McDonnell Douglas..., September 9, 2008), for certain McDonnell Douglas Corporation Model MD-90-30 airplanes. That AD requires a... fasteners in the aft mount support fitting of the left and right engines on 29 McDonnell Douglas Corporation...

  15. 75 FR 21528 - Airworthiness Directives; McDonnell Douglas Corporation Model MD-90-30 Airplanes

    Science.gov (United States)

    2010-04-26

    ...-0433; Directorate Identifier 2009-NM-117-AD] RIN 2120-AA64 Airworthiness Directives; McDonnell Douglas... main landing gear (MLG) during gear extension, damaging the hydraulic system on McDonnell Douglas.... The retract cylinder support fittings for the MLG on McDonnell Douglas Model MD-80 series airplanes...

  16. 75 FR 36577 - Airworthiness Directives; McDonnell Douglas Corporation Model MD-90-30 Airplanes

    Science.gov (United States)

    2010-06-28

    ... Airworthiness Directives; McDonnell Douglas Corporation Model MD- 90-30 Airplanes AGENCY: Federal Aviation... Douglas Corporation: Docket No. FAA-2010-0554; Directorate Identifier 2010-NM-082-AD. Comments Due Date (a... supersedes AD 2009-07-04, Amendment 39-15863. Applicability (c) This AD applies to McDonnell Douglas...

  17. 75 FR 80742 - Airworthiness Directives; McDonnell Douglas Corporation Model MD-90-30 Airplanes

    Science.gov (United States)

    2010-12-23

    ...-1202; Directorate Identifier 2010-NM-167-AD] RIN 2120-AA64 Airworthiness Directives; McDonnell Douglas... amends Sec. 39.13 by adding the following new airworthiness directive (AD): McDonnell Douglas Corporation... Douglas Corporation Model MD-90-30 airplanes, certificated in any category. Subject (d) Joint Aircraft...

  18. 75 FR 66653 - Airworthiness Directives; McDonnell Douglas Corporation Model MD-90-30 Airplanes

    Science.gov (United States)

    2010-10-29

    ... Airworthiness Directives; McDonnell Douglas Corporation Model MD- 90-30 Airplanes AGENCY: Federal Aviation...-15667 (73 FR 52203, September 9, 2008), and adding the following new AD: 2010-22-04 McDonnell Douglas... supersedes AD 2008-18-10, Amendment 39-15667. Applicability (c) This AD applies to McDonnell Douglas...

  19. Water at silica/liquid water interfaces investigated by DFT-MD simulations

    Science.gov (United States)

    Gaigeot, Marie-Pierre

    This talk is dedicated to probing the microscopic structural organization of water at silica/liquid water interfaces including electrolytes by first principles DFT-based molecular dynamics simulations (DFT-MD). We will present our very recent DFT-MD simulations of electrolytic (KCl, NaCl, NaI) silica/liquid water interfaces in order to unravel the intertwined structural properties of water and electrolytes at the crystalline quartz/liquid water and amorphous silica/liquid water interfaces. DFT-MD simulations provide direct knowledge of the structural organization of water and the H-Bond network formed between the water molecules within the different water layers above the silica surface. One can furthermore extract vibrational signatures of the water molecules within the interfacial layers from the DFT-MD simulations, especially non-linear SFG (Sum Frequency generation) signatures that are active at solid/liquid interfaces. The strength of the simulated spectra is that a detailed analysis of the signatures in terms of the water/water H-Bond networks formed within the interfacial water layers and in terms of the water/silica or water/electrolytes H-Bond networks can be given. Comparisons of SFG spectra between quartz/water/electrolytes and amorphous silica/water/electrolytes interfaces allow us to definitely conclude on how the structural arrangements of liquid water at these electrolytic interfaces modulate the final spectroscopic signatures. Invited speaker.

  20. 75 FR 51333 - Madison Square Federal Savings Bank, Baltimore, MD; Approval of Conversion Application

    Science.gov (United States)

    2010-08-19

    ... DEPARTMENT OF THE TREASURY Office of Thrift Supervision [AC-49: OTS Nos. 08156 and H4736] Madison Square Federal Savings Bank, Baltimore, MD; Approval of Conversion Application Notice is hereby given that on August 12, 2010, the Office of Thrift Supervision approved the application of Madison Square...

  1. 75 FR 24774 - Fairmount Bank, Baltimore, MD; Approval of Conversion Application

    Science.gov (United States)

    2010-05-05

    ... DEPARTMENT OF THE TREASURY Office of Thrift Supervision [AC-36 OTS Nos. 08193 and H4677] Fairmount Bank, Baltimore, MD; Approval of Conversion Application Notice is hereby given that on April 15, 2010, the Office of Thrift Supervision approved the application of Fairmount Bank, Baltimore, Maryland, to...

  2. 75 FR 31511 - Ideal Federal Savings Bank, Baltimore, MD; Approval of Conversion Application

    Science.gov (United States)

    2010-06-03

    ... DEPARTMENT OF THE TREASURY Office of Thrift Supervision [AC-46: OTS No. 08283] Ideal Federal Savings Bank, Baltimore, MD; Approval of Conversion Application Notice is hereby given that on May 24, 2010, the Office of Thrift Supervision approved the application of Ideal Federal Savings Bank...

  3. 77 FR 68149 - Karen Paul Holley, M.D.; Decision and Order

    Science.gov (United States)

    2012-11-15

    ... DEPARTMENT OF JUSTICE Drug Enforcement Administration [Docket No. 12-51] Karen Paul Holley, M.D... revoke the DEA Certificate of Registration (COR), Number BH8988339, of Karen Paul Holley, M.D....D., 74 FR 17528, 174529 (2009); John B. Freitas, D.O., 74 FR 17524, 17525 (2009); Roger A. Rodriguez...

  4. 76 FR 20034 - Calvin Ramsey, M.D.; Revocation of Registration

    Science.gov (United States)

    2011-04-11

    ... DEPARTMENT OF JUSTICE Drug Enforcement Administration [Docket No. 10-25] Calvin Ramsey, M.D.; Revocation of Registration On December 18, 2009, the Deputy Assistant Administrator, Office of Diversion... constitutional right to appointed counsel in a proceeding under 21 U.S.C. 824(a). See Goldberg v. Kelly, 397 U.S...

  5. 76 FR 9407 - Fraternity Federal Savings & Loan Association, Baltimore, MD; Approval of Conversion Application

    Science.gov (United States)

    2011-02-17

    ... DEPARTMENT OF THE TREASURY Office of Thrift Supervision [AC-58 OTS No. 01292 and H 4762] Fraternity Federal Savings & Loan Association, Baltimore, MD; Approval of Conversion Application Notice is hereby given that on February 10, 2011, the Office of Thrift Supervision approved the application of...

  6. 75 FR 49956 - Dewey C. Mackay, M.D.; Revocation of Registration

    Science.gov (United States)

    2010-08-16

    ... DEPARTMENT OF JUSTICE Drug Enforcement Administration [Docket No. 09-28] Dewey C. Mackay, M.D.; Revocation of Registration On February 26, 2009, I, the Deputy Administrator of the Drug Enforcement Administration (DEA), issued an Order to Show Cause and Immediate Suspension of Registration to Dewey C. MacKay...

  7. 76 FR 65118 - Drawbridge Operation Regulation; Bear Creek, Sparrows Point, MD

    Science.gov (United States)

    2011-10-20

    ...-AA09 Drawbridge Operation Regulation; Bear Creek, Sparrows Point, MD AGENCY: Coast Guard, DHS. ACTION... regulation. The Baltimore County Revenue Authority (Dundalk Avenue) highway toll drawbridge across Bear Creek... applicable or necessary. Basis and Purpose The drawbridge across Bear Creek, mile 1.5 was removed and...

  8. Going Concern Opinions and Management's Forward Looking Disclosures: Evidence from the MD&A

    NARCIS (Netherlands)

    Enev, M.; Geiger, Marshall; Gold, A.H.; Wallage, P.

    In this study we examine the relationship between the auditor’s going concern opinion and management’s forward-looking disclosures in the Management’s Discussion and Analysis (MD&A) section of 10-K filings. The research objective is two-fold and addresses whether the presence of a going concern

  9. 77 FR 35054 - Donald Brooks Reece II, M.D.; Dismissal of Proceeding

    Science.gov (United States)

    2012-06-12

    ..., M.D. (Respondent), of Morehead City, N.C. The Order proposed the revocation of Respondent's DEA... pleading entitled: ``Notice To The Administrator Regarding State Authority,'' with attachments. Therein..., at 3. This Order was effective on December 8, 2011. Id., Attachment 5, at 6. Upon review of the...

  10. 75 FR 18056 - Safety Zone; Fireworks Display, Patuxent River, Solomons Island Harbor, MD

    Science.gov (United States)

    2010-04-09

    ... the event, and enhancing public and maritime safety. Basis and Purpose Fireworks displays are... promote public and maritime safety during a fireworks display, and to protect mariners transiting the area...-AA00 Safety Zone; Fireworks Display, Patuxent River, Solomons Island Harbor, MD AGENCY: Coast Guard...

  11. MD#2183: Calibration of the IR6 B2 diamond BLMs

    CERN Document Server

    Valette, Matthieu; Lindstrom, Bjorn Hans Filip

    2018-01-01

    In case of an asynchronous beam dump with a fully filled LHC machine, causing ~40 bunches to impact on the movable dump protection absorber (TCDQ), it is expected that all standard ionisation chamber Beam Loss Monitors (IC BLM) around the LHC dumping region in IR6 will be saturated. Diamond Beam Loss Monitors (dBLM) were therefore installed next to the TCDQ downstream of the extraction kickers. These detectors allow resolving losses at a nanosecond timescale and with a dynamic range of several orders of magnitude; thus, allowing to derive the number of nominal bunches impacting the TCDQ. After a first series of calibrations using asynchronous beam dump tests, an experiment was conducted during MD#1182 to demonstrate the possibility of resolving a nominal bunch hitting the TCDQ. During this first MD only the Beam 1 dBLM was calibrated appropriately, a second calibration MD was therefore performed in 2017 for the B2 system. Results from this MD and conclusions regarding dBLM saturation with a top energy nominal...

  12. 76 FR 71369 - Robert G. Crummie, M.D.; Decision and Order

    Science.gov (United States)

    2011-11-17

    ... agencies to perform meaningless tasks. See Layfe Robert Anthony, M.D., 67 FR 35582 (DEA 2002); Michael G.... Kirk v. Mullen, 749 F.2d 297 (6th Cir. 1984); Puerto Rico Aqueduct and Sewer Auth. v. EPA, 35 F.3d 600...

  13. The draft genome of MD-2 pineapple using hybrid error correction of long reads

    Science.gov (United States)

    Redwan, Raimi M.; Saidin, Akzam; Kumar, S. Vijay

    2016-01-01

    The introduction of the elite pineapple variety, MD-2, has caused a significant market shift in the pineapple industry. Better productivity, overall increased in fruit quality and taste, resilience to chilled storage and resistance to internal browning are among the key advantages of the MD-2 as compared with its previous predecessor, the Smooth Cayenne. Here, we present the genome sequence of the MD-2 pineapple (Ananas comosus (L.) Merr.) by using the hybrid sequencing technology from two highly reputable platforms, i.e. the PacBio long sequencing reads and the accurate Illumina short reads. Our draft genome achieved 99.6% genome coverage with 27,017 predicted protein-coding genes while 45.21% of the genome was identified as repetitive elements. Furthermore, differential expression of ripening RNASeq library of pineapple fruits revealed ethylene-related transcripts, believed to be involved in regulating the process of non-climacteric pineapple fruit ripening. The MD-2 pineapple draft genome serves as an example of how a complex heterozygous genome is amenable to whole genome sequencing by using a hybrid technology that is both economical and accurate. The genome will make genomic applications more feasible as a medium to understand complex biological processes specific to pineapple. PMID:27374615

  14. 78 FR 11142 - Connor Hayden Kraegel, 19917 Spurrier Avenue, Poolesville, MD 20837; Order Denying Export Privileges

    Science.gov (United States)

    2013-02-15

    ... DEPARTMENT OF COMMERCE Bureau of Industry and Security Connor Hayden Kraegel, 19917 Spurrier... Court, District of Maryland, Connor Hayden Kraegel (``Kraegel'') was convicted of violating Section 38... Hayden Kraegel, with a last known address at: 19917 Spurrier Avenue, Poolesville, MD 20837, and when...

  15. 75 FR 51945 - Safety Zone; Potomac River, St. Mary's River, St. Inigoes, MD

    Science.gov (United States)

    2010-08-24

    ...-AA00 Safety Zone; Potomac River, St. Mary's River, St. Inigoes, MD AGENCY: Coast Guard, DHS. ACTION... of the St. Mary's River, a tributary of the Potomac River. This action is necessary to provide for.... Navy helicopter located near St. Inigoes, Maryland. This safety zone is intended to protect the...

  16. Heat Flow Data Cruise MD72 RV Marion Dufresne over the Mascarene Ridge

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Data were gathered by the R/V Marion Dufresne in May and June of 1992 over the Mascarene Ridge in the Indian Ocean on cruise MD72/MASCAFLUX. Heat flow measurements...

  17. 75 FR 53574 - Safety Zone; Fireworks Displays, Potomac River, National Harbor, MD

    Science.gov (United States)

    2010-09-01

    ...-AA00 Safety Zone; Fireworks Displays, Potomac River, National Harbor, MD AGENCY: Coast Guard, DHS... safety of life on navigable waters during five fireworks displays launched from a discharge barge located... necessary to protect persons and vessels against the hazards associated with a fireworks display on...

  18. 78 FR 68002 - Safety Zone for Fireworks Display, Baltimore Harbor, Baltimore, MD

    Science.gov (United States)

    2013-11-13

    ... 1625-AA00 Safety Zone for Fireworks Display, Baltimore Harbor, Baltimore, MD AGENCY: Coast Guard, DHS... safety of life on navigable waters during a fireworks display launched from a barge located in Baltimore... rule involves a fireworks display associated with a New Year's Eve event that will take place in...

  19. 77 FR 11434 - Safety Zone; Patapsco River, Northwest and Inner Harbors, Baltimore, MD

    Science.gov (United States)

    2012-02-27

    ...-AA00 Safety Zone; Patapsco River, Northwest and Inner Harbors, Baltimore, MD AGENCY: Coast Guard, DHS... intended route immediately prior to, during, and following the scheduled towing evolution, vessel traffic... made to the maritime community via marine information broadcasts so mariners may adjust their plans...

  20. InforMD: a new initiative to raise public awareness about breast density.

    Science.gov (United States)

    Hugo, Honor J; Zysk, Aneta; Dasari, Pallave; Britt, Kara; Hopper, John L; Stone, Jennifer; Thompson, Erik W; Ingman, Wendy V

    2018-01-01

    On a mammogram, breast density (also known as mammographic density) is shown as white and bright regions and is associated with reduced sensitivity in cancer detection and increased breast cancer risk. However, many Australian women are unaware of the significance of breast density as it is not routinely reported or discussed. In order to address this lack of knowledge, Australian breast cancer researchers with expertise in mammographic density formed the InforMD alliance (INformation FORum on Mammographic Density) in 2016. The alliance is working to raise awareness of breast density with the goal of improving breast cancer diagnosis and health outcomes for women. The InforMD website (www.InforMD.org.au) was launched in October 2016, coinciding with a major nationwide public awareness campaign by the alliance during breast cancer awareness month. The website contains unbiased, accurate, updated information on breast density. The website also provides summaries of major research articles in layperson language, recent news items related to breast density, links to relevant information for health professionals, events, and feature articles. Members of the public and health professionals can also subscribe for news updates. The interactive online Forum section facilitates discussion between health professionals, scientists and members of the public. To increase online traffic to the website, Facebook (www.facebook.com/BeInforMD) and Twitter (https://twitter.com/BeInforMD_) pages were launched in December 2016. Since its launch, InforMD has generated considerable interest. The public awareness campaign reached over 7 million Australians through a combination of newspaper, TV, radio, and online news. The website has attracted 13,058 unique visitors and 30,353 page views (data as of 19/12/2017). Breast cancer researchers have a significant role to play in disseminating information to the public on breast density. A combination of mainstream and social media, together with

  1. JST Thesaurus Headwords and Synonyms: Md [MeCab user dictionary for science technology term[Archive

    Lifescience Database Archive (English)

    Full Text Available MeCab user dictionary for science technology term Md 名詞 一般 * * * * メンデレビウム メンデレビウム メンデレビューム Thesaurus2015 200906022783221535 C CA03 UNKNOWN_1 Md

  2. DMPD: Innate recognition of lipopolysaccharide by Toll-like receptor 4-MD-2. [Dynamic Macrophage Pathway CSML Database

    Lifescience Database Archive (English)

    Full Text Available 15051069 Innate recognition of lipopolysaccharide by Toll-like receptor 4-MD-2. Miy...ake K. Trends Microbiol. 2004 Apr;12(4):186-92. (.png) (.svg) (.html) (.csml) Show Innate recognition of lip...opolysaccharide by Toll-like receptor 4-MD-2. PubmedID 15051069 Title Innate recognition of lipopolysacchari

  3. 33 CFR 334.155 - Severn River, Naval Station Annapolis, Small Boat Basin, Annapolis, MD; naval restricted area.

    Science.gov (United States)

    2010-07-01

    ... Annapolis, Small Boat Basin, Annapolis, MD; naval restricted area. 334.155 Section 334.155 Navigation and... RESTRICTED AREA REGULATIONS § 334.155 Severn River, Naval Station Annapolis, Small Boat Basin, Annapolis, MD; naval restricted area. (a) The area. The waters within the Naval Station Annapolis small boat basin and...

  4. Usefulness of multidetector-row computed tomography (MD-CT) for diagnosis and evaluation of cardiovascular anomalies in infants

    International Nuclear Information System (INIS)

    Kani, Hiroyuki; Narabayashi, Isamu; Tanikake, Masato; Matsuki, Mitsuru; Uesugi, Yasuo

    2005-01-01

    We examined the effectiveness of multidetector-row CT (MD-CT) in the diagnosis and evaluation of cardiovascular anomalies in infants. MD-CT was performed 34 times on 21 patients with cardiovascular anomalies. We performed three evaluations: 1) The assessment of the specificity of MD-CT in detecting the morphological features of cardiovascular anomalies. 2) The diameters of aortae with coronary artery (CoA), and the diameters of pulmonary artery, measured by using MD-CT were compared with those by angiography. 3) The amount of exposure to radiation was measured. 1) MD-CT can detect CoA, pulmonary arteriovenous anomalies among extracardiac anomalies in all the patients. The diagnostic accuracy for intracardiac anomalies was poor as only six of the 15 anomalies could be accurately diagnosed. 2) The diameters of aortae and pulmonary artery obtained using MD-CT showed a good correlation with those obtained using arteriography (r=0.97, 0.95). 3) The average dose-length product was 269.2 mGy·cm. And the average effective dose was 5.1 mSv. MD-CT is not suitable for the evaluation of intracardiac anomalies, but is extremely effective in the evaluation of extracardiac major vascular anomalies. On the basis of the amount of information and noninvasive nature, MD-CT should be used first before angiography. (author)

  5. The Convergence of Business and Medicine: A Study of MD/MBA Programs in the United States

    Science.gov (United States)

    Keogh, Timothy J.; Martin, William Marty

    2011-01-01

    The purpose of this paper is to identify the convergence of business and medical education and describe the curricula of MD/MBA (Medical Doctor/Master of Business Administration) programs in the US. The focus of this study is to provide a guide to dual MD/MBA programs for physicians, aspiring physicians, policy makers and healthcare organizations.…

  6. Análise Bibliométrica da produção científica em gestão da informação na base de dados lisa / Bibliometrics analysis of scientific production in management information in the lisa database

    OpenAIRE

    Luiza da Silva Kleinubing

    2010-01-01

    Descreve e analisa as principais características bibliométricas das publicações relacionadas à área de gestão da informação da base de dados Lisa, uma das bases com maior visibilidade no campo da Biblioteconomia e Ciência da Informação. Foram analisados 138 artigos. A metodologia de pesquisa combina métodos bibliométricos e softwares, a característica da pesquisa é quantitativa, pois enumera e mede, e qualitativa, pois compreende e explica. Conclui-se sinalizando que os métodos bibliométricos...

  7. Applicability of effective fragment potential version 2 - Molecular dynamics (EFP2-MD) simulations for predicting excess properties of mixed solvents

    Science.gov (United States)

    Kuroki, Nahoko; Mori, Hirotoshi

    2018-02-01

    Effective fragment potential version 2 - molecular dynamics (EFP2-MD) simulations, where the EFP2 is a polarizable force field based on ab initio electronic structure calculations were applied to water-methanol binary mixture. Comparing EFP2s defined with (aug-)cc-pVXZ (X = D,T) basis sets, it was found that large sets are necessary to generate sufficiently accurate EFP2 for predicting mixture properties. It was shown that EFP2-MD could predict the excess molar volume. Since the computational cost of EFP2-MD are far less than ab initio MD, the results presented herein demonstrate that EFP2-MD is promising for predicting physicochemical properties of novel mixed solvents.

  8. Assessing the allelotypic effect of two aminocyclopropane carboxylic acid synthase-encoding genes MdACS1 and MdACS3a on fruit ethylene production and softening in Malus

    Science.gov (United States)

    Dougherty, Laura; Zhu, Yuandi; Xu, Kenong

    2016-01-01

    Phytohormone ethylene largely determines apple fruit shelf life and storability. Previous studies demonstrated that MdACS1 and MdACS3a, which encode 1-aminocyclopropane-1-carboxylic acid synthases (ACS), are crucial in apple fruit ethylene production. MdACS1 is well-known to be intimately involved in the climacteric ethylene burst in fruit ripening, while MdACS3a has been regarded a main regulator for ethylene production transition from system 1 (during fruit development) to system 2 (during fruit ripening). However, MdACS3a was also shown to have limited roles in initiating the ripening process lately. To better assess their roles, fruit ethylene production and softening were evaluated at five time points during a 20-day post-harvest period in 97 Malus accessions and in 34 progeny from 2 controlled crosses. Allelotyping was accomplished using an existing marker (ACS1) for MdACS1 and two markers (CAPS866 and CAPS870) developed here to specifically detect the two null alleles (ACS3a-G289V and Mdacs3a) of MdACS3a. In total, 952 Malus accessions were allelotyped with the three markers. The major findings included: The effect of MdACS1 was significant on fruit ethylene production and softening while that of MdACS3a was less detectable; allele MdACS1–2 was significantly associated with low ethylene and slow softening; under the same background of the MdACS1 allelotypes, null allele Mdacs3a (not ACS3a-G289V) could confer a significant delay of ethylene peak; alleles MdACS1–2 and Mdacs3a (excluding ACS3a-G289V) were highly enriched in M. domestica and M. hybrid when compared with those in M. sieversii. These findings are of practical implications in developing apples of low and delayed ethylene profiles by utilizing the beneficial alleles MdACS1-2 and Mdacs3a. PMID:27231553

  9. MD and FFM Electron Broadening for Warm and Dense Hydrogen Plasmas

    International Nuclear Information System (INIS)

    Ferri, S.; Calisti, A.; Mosse, C.; Talin, B.; Gonzalez, M. A.; Gigosos, M. A.

    2006-01-01

    Direct integration of the semi-classical evolution equation based on Molecular Dynamics simulations (MD) and the Frequency Fluctuation Model (FFM) have long been used to synthesize spectra accounting for ion dynamics. Cross comparisons of these approaches generally show results in good agreement. Recently, interest in low temperature (Te ∼ 1eV) and high density (Ne ∼ 1018 cm-3) hydrogen plasma spectroscopy has motivated extended applications of FFM. Arising discrepancies were found to originate in electron collision operators suggesting an improper use of impact approximations for warm and dense plasma conditions. In order to clarify this point, new useful cross comparisons between MD and FFM have been carried out for electron broadening

  10. MD1831: Single Bunch Instabilities with Q" and Non-Linear Corrections

    CERN Document Server

    Carver, Lee Robert; De Maria, Riccardo; Li, Kevin Shing Bruce; Amorim, David; Biancacci, Nicolo; Buffat, Xavier; Maclean, Ewen Hamish; Metral, Elias; Lasocha, Kacper; Lefevre, Thibaut; Levens, Tom; Salvant, Benoit; CERN. Geneva. ATS Department

    2017-01-01

    During MD1751, it was observed that both a full single beam and 964 non-colliding bunches in Beam 1 (B1) and Beam 2 (B2) were both stable at the End of Squeeze (EOS) for 0A in the Landau Octupoles. At ß* = 40cm there is also a significant Q" arising from the lattice, as well as uncorrected non-linearities in the Insertion Regions (IRs). Each of these effects could be capable of fully stabilising the beam. This MD made first use of a Q" knob through variation of the Main Sextupoles (MS) by stabilising a single bunch at Flat Top, before showing at EOS that the non-linearities were the main contributors to the beam stability.

  11. Microsecond MD Simulations of Nano-patterned Polymer Brushes on Self-Assembled Monolayers

    Science.gov (United States)

    Buie, Creighton; Qiu, Liming; Cheng, Kwan; Park, Soyeun

    2010-03-01

    Nano-patterned polymer brushes end-grafted onto self-assembled monolayers have gained increasing research interests due to their unique thermodynamic properties and their chemical and biomedical applications in colloids, biosensing and tissue engineering. So far, the interactions between the polymer brushes with the surrounding environments such as the floor and solvent at the nanometer length scale and microsecond time scale are still difficult to obtained experimentally and computationally. Using a Coarse-Grained MD approach, polymer brushes of different monomeric lengths, grafting density and hydrophobicity of the monomers grafted on self-assembled monolayers and in explicit solvent were studied. Molecular level information, such as lateral diffusion, transverse height and volume contour of the brushes, were calculated from our microsecond-MD simulations. Our results demonstrated the significance of the hydration of the polymer in controlling the conformational arrangement of the polymer brushes.

  12. MD-portal: Highly Effective Website for Nuclear Materials Information Management

    International Nuclear Information System (INIS)

    Kil, Soyeon; Lee, Gyeonggeun; Kwon, Junhyun

    2014-01-01

    A web-based system is widespread in not only everyday activities but also business fields. In past years, the systematic information of various properties of materials usually has been provided as tabulated documents; however it recently has been provided as web-based DB. There are many websites providing material properties information, representative examples include MatWeb from the United States, Granta MI from England and MatNavi from Japan. In 2003, the nuclear materials division in KAERI established a website about nuclear materials property DB, called MatDB. To inherit it, a website called MD-portal has been recently set up to release degradation information and various properties of nuclear materials. In this presentation, the structure and characteristics of MD-portal will be mentioned, and comments on its application will be given

  13. Discovering and Developing Successful Cardiovascular Therapeutics: A Conversation With James N. Topper, MD, PhD.

    Science.gov (United States)

    Topper, James N; Rutherford, John D

    2016-11-15

    Dr James (also known as Jamie) N. Topper, MD, PhD, serves as Managing General Partner at Frazier Healthcare Partners, where he leads the Life Science Venture practice. In 2011, and 2016, he was named to the Midas List of leading venture capitalists, and, in 2013, he was recognized by Forbes as one of the top 10 healthcare investors. He has >25 years of experience working with entrepreneurs to found and build successful therapeutics-focused companies. Dr Topper holds a BS from the University of Michigan. He received an MD and PhD (in biophysics) from Stanford University School of Medicine. He completed postgraduate training in internal medicine and cardiovascular disease at the Brigham and Women's Hospital in Boston and is board certified in both disciplines. © 2016 American Heart Association, Inc.

  14. MD-CTS: An integrated terminology reference of clinical and translational medicine

    Directory of Open Access Journals (Sweden)

    Will Ray

    2016-01-01

    Full Text Available New vocabularies are rapidly evolving in the literature relative to the practice of clinical medicine and translational research. To provide integrated access to new terms, we developed a mobile and desktop online reference—Marshfield Dictionary of Clinical and Translational Science (MD-CTS. It is the first public resource that comprehensively integrates Wiktionary (word definition, BioPortal (ontology, Wiki (image reference, and Medline abstract (word usage information. MD-CTS is accessible at http://spellchecker.mfldclin.edu/. The website provides a broadened capacity for the wider clinical and translational science community to keep pace with newly emerging scientific vocabulary. An initial evaluation using 63 randomly selected biomedical words suggests that online references generally provided better coverage (73%-95% than paper-based dictionaries (57–71%.

  15. A virtual observatory for photoionized nebulae: the Mexican Million Models database (3MdB).

    Science.gov (United States)

    Morisset, C.; Delgado-Inglada, G.; Flores-Fajardo, N.

    2015-04-01

    Photoionization models obtained with numerical codes are widely used to study the physics of the interstellar medium (planetary nebulae, HII regions, etc). Grids of models are performed to understand the effects of the different parameters used to describe the regions on the observables (mainly emission line intensities). Most of the time, only a small part of the computed results of such grids are published, and they are sometimes hard to obtain in a user-friendly format. We present here the Mexican Million Models dataBase (3MdB), an effort to resolve both of these issues in the form of a database of photoionization models, easily accessible through the MySQL protocol, and containing a lot of useful outputs from the models, such as the intensities of 178 emission lines, the ionic fractions of all the ions, etc. Some examples of the use of the 3MdB are also presented.

  16. LHC MD 652: Coupled-Bunch Instability with Smaller Emittance (all HOMs)

    CERN Document Server

    AUTHOR|(CDS)2081238; Timko, Helga; CERN. Geneva. ATS Department

    2017-01-01

    The aim of the MD was to measure the coupled-bunch stability from all HOM impedances, with a reduced longitudinal emittance in order to explore the HL-LHC conditions. The acceleration ramp was performed with the nominal beams of 2016, but a reduced target bunch length and RF voltage. With this reduced emittance, the beam remained close but above the single-bunch stability threshold. No coupled-bunch oscillations were observed, so we can conclude that the stability threshold for coupled-bunch instability is not lower than the single-bunch threshold. An interesting observation in the MD was the long-lasting injection oscillations, whose traces can still be seen at arrival to flat top; in agreement with observations in earlier MDs. The measurements took place between 28th October 20:00 and 29th October 05:10.

  17. Virtual synthesis of crystals using ab initio MD: Case study on LiFePO4

    Science.gov (United States)

    Mishra, S. B.; Nanda, B. R. K.

    2017-05-01

    Molecular dynamics simulation technique is fairly successful in studying the structural aspects and dynamics of fluids. Here we study the ability of ab initio molecular dynamics (ab initio MD) to carry out virtual experiments to synthesize new crystalline materials and to predict their structures. For this purpose the olivine phosphate LiFePO4 (LFPO) is used as an example. As transition metal oxides in general are stabilized with layered geometry, we carried out ab initio MD simulations over a hypothetical layered configuration consisting of alternate LiPO2 and FeO2 layers. With intermittent steps of electron minimization, the resulted equilibrium lattice consist of PO4 tetrahedra and distorted Fe-O complexes similar to the one observed in the experimental lattice.

  18. β∗ levelling using the LHC Lumi Server (MD 2427)

    CERN Document Server

    Hostettler, Michi; Fuchsberger, Kajetan; Gabriel, Mathieu; Hemelsoet, Georges-Henry; Hruska, Marek; Jacquet, Delphine; Wenninger, Jorg; CERN. Geneva. ATS Department

    2018-01-01

    Luminosity levelling by β∗ is the baseline scenario for HL-LHC and will possibly be used in 2018 LHC operation. In this MD, we commissioned a novel controls approach to β∗ levelling using improved LSA trims and automatic orchestration. Compared to the regular squeeze using sequences, this approach is aimed to be minimally invasive to LHC operation in Stable Beams. Using this tool, we demonstrated the feasibility of β∗ levelling between 1 m and 30 cm.

  19. PyContact: Rapid, Customizable, and Visual Analysis of Noncovalent Interactions in MD Simulations.

    Science.gov (United States)

    Scheurer, Maximilian; Rodenkirch, Peter; Siggel, Marc; Bernardi, Rafael C; Schulten, Klaus; Tajkhorshid, Emad; Rudack, Till

    2018-02-06

    Molecular dynamics (MD) simulations have become ubiquitous in all areas of life sciences. The size and model complexity of MD simulations are rapidly growing along with increasing computing power and improved algorithms. This growth has led to the production of a large amount of simulation data that need to be filtered for relevant information to address specific biomedical and biochemical questions. One of the most relevant molecular properties that can be investigated by all-atom MD simulations is the time-dependent evolution of the complex noncovalent interaction networks governing such fundamental aspects as molecular recognition, binding strength, and mechanical and structural stability. Extracting, evaluating, and visualizing noncovalent interactions is a key task in the daily work of structural biologists. We have developed PyContact, an easy-to-use, highly flexible, and intuitive graphical user interface-based application, designed to provide a toolkit to investigate biomolecular interactions in MD trajectories. PyContact is designed to facilitate this task by enabling identification of relevant noncovalent interactions in a comprehensible manner. The implementation of PyContact as a standalone application enables rapid analysis and data visualization without any additional programming requirements, and also preserves full in-program customization and extension capabilities for advanced users. The statistical analysis representation is interactively combined with full mapping of the results on the molecular system through the synergistic connection between PyContact and VMD. We showcase the capabilities and scientific significance of PyContact by analyzing and visualizing in great detail the noncovalent interactions underlying the ion permeation pathway of the human P2X 3 receptor. As a second application, we examine the protein-protein interaction network of the mechanically ultrastable cohesin-dockering complex. Copyright © 2017 Biophysical Society

  20. Prevalence of mood disorders and utility of the PRIME-MD in patients undergoing radiation therapy

    International Nuclear Information System (INIS)

    Leopold, Kenneth A.; Ahles, Tim A.; Walch, Susan; Amdur, Robert J.; Mott, Leila A.; Wiegand-Packard, Linda; Oxman, Thomas E.

    1998-01-01

    Purpose: To validate a short, structured interview procedure that allows practicing oncologists to quickly and reliably identify mood disorders in their patients, and to estimate the prevalence and types of mood disorders in a radiation therapy patient setting, noting relationships between mood disorders and patient characteristics. Methods: Consecutive, eligible adult patients from the practices of two radiation oncologists were administered the Primary Care Evaluation of Mental Disorders (PRIME-MD) by the treating physician. A subset of these patients was also evaluated with the SCID, administered by trained mental health care personnel. Agreement between the two instruments was examined using the kappa statistic. Prevalence of mood disorders was determined from the PRIME-MD. The significance of relationships between patient characteristics and mood disorders was examined by chi-square and ANOVA analysis, and subsequently by multivariate logistic regression analysis. Results: One hundred twenty-two patients were studied. Fifty-three of these were administered the SCID. Agreement between the two instruments was very good (kappa = 0.70). A diagnosis of a depressive or anxiety disorder by the PRIME-MD was made in 59 of the 122 patients (48%, 95% confidence interval = 39%, 58%). Multivariate analysis showed that a diagnosis of a depressive mood disorder was significantly related to pain intensity and prior history of depression. Conclusion: We have demonstrated the validity and feasibility of the PRIME-MD administered by oncologists in making diagnoses of mood disorders. The prevalence of mood disorders in our set of patients undergoing a course of RT was nearly 50%. Future studies should describe the natural history of these disorders, and determine optimal intervention strategies

  1. MD 2408: Study of Schottky Monitors for Q' Measurement at Injection

    CERN Document Server

    Tydecks, Tobias; Levens, Tom; Wendt, Manfred; Wenninger, Jorg; CERN. Geneva. ATS Department

    2018-01-01

    The Schottky monitors installed at the LHC enable the detection of Schottky noise of the two circulating proton / ion beams. From Schottky noise, beam parameters like tune, chromaticity, and relative emittance, can be extracted in a non-destructive and purely parasitic method of measurement. The primary goal of this MD was to study the Schottky monitors capability to reliably and accurately determine the beam chromaticities at injection energy. Furthermore, the possibility to track the beam emittance has been investigated.

  2. An Efficient Hybrid DSMC/MD Algorithm for Accurate Modeling of Micro Gas Flows

    KAUST Repository

    Liang, Tengfei

    2013-01-01

    Aiming at simulating micro gas flows with accurate boundary conditions, an efficient hybrid algorithmis developed by combining themolecular dynamics (MD) method with the direct simulationMonte Carlo (DSMC)method. The efficiency comes from the fact that theMD method is applied only within the gas-wall interaction layer, characterized by the cut-off distance of the gas-solid interaction potential, to resolve accurately the gas-wall interaction process, while the DSMC method is employed in the remaining portion of the flow field to efficiently simulate rarefied gas transport outside the gas-wall interaction layer. A unique feature about the present scheme is that the coupling between the two methods is realized by matching the molecular velocity distribution function at the DSMC/MD interface, hence there is no need for one-toone mapping between a MD gas molecule and a DSMC simulation particle. Further improvement in efficiency is achieved by taking advantage of gas rarefaction inside the gas-wall interaction layer and by employing the "smart-wall model" proposed by Barisik et al. The developed hybrid algorithm is validated on two classical benchmarks namely 1-D Fourier thermal problem and Couette shear flow problem. Both the accuracy and efficiency of the hybrid algorithm are discussed. As an application, the hybrid algorithm is employed to simulate thermal transpiration coefficient in the free-molecule regime for a system with atomically smooth surface. Result is utilized to validate the coefficients calculated from the pure DSMC simulation with Maxwell and Cercignani-Lampis gas-wall interaction models. ©c 2014 Global-Science Press.

  3. Investigation on single carbon atom transporting through the single-walled carbon nanotube by MD simulation

    International Nuclear Information System (INIS)

    Ding Yinfeng; Zhang Zhibin; Ke Xuezhi; Zhu Zhiyuan; Zhu Dezhang; Wang Zhenxia; Xu Hongjie

    2005-01-01

    The single carbon atom transporting through the single-walled carbon nanotube has been studied by molecular-dynamics (MD) simulation. We got different trajectories of the carbon atom by changing the input parameters. The simulation results indicate that the single carbon atom with low energy can transport through the carbon nanotube under some input conditions and result in different trajectories being straight line or 'rosette' or circular. (authors)

  4. Wettability of graphitic-carbon and silicon surfaces: MD modeling and theoretical analysis

    International Nuclear Information System (INIS)

    Ramos-Alvarado, Bladimir; Kumar, Satish; Peterson, G. P.

    2015-01-01

    The wettability of graphitic carbon and silicon surfaces was numerically and theoretically investigated. A multi-response method has been developed for the analysis of conventional molecular dynamics (MD) simulations of droplets wettability. The contact angle and indicators of the quality of the computations are tracked as a function of the data sets analyzed over time. This method of analysis allows accurate calculations of the contact angle obtained from the MD simulations. Analytical models were also developed for the calculation of the work of adhesion using the mean-field theory, accounting for the interfacial entropy changes. A calibration method is proposed to provide better predictions of the respective contact angles under different solid-liquid interaction potentials. Estimations of the binding energy between a water monomer and graphite match those previously reported. In addition, a breakdown in the relationship between the binding energy and the contact angle was observed. The macroscopic contact angles obtained from the MD simulations were found to match those predicted by the mean-field model for graphite under different wettability conditions, as well as the contact angles of Si(100) and Si(111) surfaces. Finally, an assessment of the effect of the Lennard-Jones cutoff radius was conducted to provide guidelines for future comparisons between numerical simulations and analytical models of wettability

  5. A comparative study of Message Digest 5(MD5) and SHA256 algorithm

    Science.gov (United States)

    Rachmawati, D.; Tarigan, J. T.; Ginting, A. B. C.

    2018-03-01

    The document is a collection of written or printed data containing information. The more rapid advancement of technology, the integrity of a document should be kept. Because of the nature of an open document means the document contents can be read and modified by many parties so that the integrity of the information as a content of the document is not preserved. To maintain the integrity of the data, it needs to create a mechanism which is called a digital signature. A digital signature is a specific code which is generated from the function of producing a digital signature. One of the algorithms that used to create the digital signature is a hash function. There are many hash functions. Two of them are message digest 5 (MD5) and SHA256. Those both algorithms certainly have its advantages and disadvantages of each. The purpose of this research is to determine the algorithm which is better. The parameters which used to compare that two algorithms are the running time and complexity. The research results obtained from the complexity of the Algorithms MD5 and SHA256 is the same, i.e., ⊖ (N), but regarding the speed is obtained that MD5 is better compared to SHA256.

  6. Going beyond clustering in MD trajectory analysis: an application to villin headpiece folding.

    Directory of Open Access Journals (Sweden)

    Aruna Rajan

    2010-04-01

    Full Text Available Recent advances in computing technology have enabled microsecond long all-atom molecular dynamics (MD simulations of biological systems. Methods that can distill the salient features of such large trajectories are now urgently needed. Conventional clustering methods used to analyze MD trajectories suffer from various setbacks, namely (i they are not data driven, (ii they are unstable to noise and changes in cut-off parameters such as cluster radius and cluster number, and (iii they do not reduce the dimensionality of the trajectories, and hence are unsuitable for finding collective coordinates. We advocate the application of principal component analysis (PCA and a non-metric multidimensional scaling (nMDS method to reduce MD trajectories and overcome the drawbacks of clustering. To illustrate the superiority of nMDS over other methods in reducing data and reproducing salient features, we analyze three complete villin headpiece folding trajectories. Our analysis suggests that the folding process of the villin headpiece is structurally heterogeneous.

  7. Novel 3D/VR interactive environment for MD simulations, visualization and analysis.

    Science.gov (United States)

    Doblack, Benjamin N; Allis, Tim; Dávila, Lilian P

    2014-12-18

    The increasing development of computing (hardware and software) in the last decades has impacted scientific research in many fields including materials science, biology, chemistry and physics among many others. A new computational system for the accurate and fast simulation and 3D/VR visualization of nanostructures is presented here, using the open-source molecular dynamics (MD) computer program LAMMPS. This alternative computational method uses modern graphics processors, NVIDIA CUDA technology and specialized scientific codes to overcome processing speed barriers common to traditional computing methods. In conjunction with a virtual reality system used to model materials, this enhancement allows the addition of accelerated MD simulation capability. The motivation is to provide a novel research environment which simultaneously allows visualization, simulation, modeling and analysis. The research goal is to investigate the structure and properties of inorganic nanostructures (e.g., silica glass nanosprings) under different conditions using this innovative computational system. The work presented outlines a description of the 3D/VR Visualization System and basic components, an overview of important considerations such as the physical environment, details on the setup and use of the novel system, a general procedure for the accelerated MD enhancement, technical information, and relevant remarks. The impact of this work is the creation of a unique computational system combining nanoscale materials simulation, visualization and interactivity in a virtual environment, which is both a research and teaching instrument at UC Merced.

  8. An assessment of communication skills of the MD/MS students of institute of medicine in Nepal

    Directory of Open Access Journals (Sweden)

    Jagdish Prasad Agrawal

    2013-09-01

    Full Text Available Introduction The main objective of this study was to assess the level of interpersonal communication skills of MD/MS resident doctors and to provide recommendations for the future. Methods Descriptive, cross sectional, qualitative and quantitative research design was used. 7- point Likert scale (0 to 6 MAAS-Global scoring instrument was used. The subjects of the research were the MD/MS residents from various departments of Maharajgunj Medical Campus (MMC of Institute of Medicine, Maharajgunj, Kathmandu. Out of 162 MD/MS residents, only 30 (18.5% MD/MS residents were selected for the sample size for the study from 1st, 2nd and 3rd year. One MD/MS resident was required four video recording to conduct four interviews with patients coming to the outpatient department. Results There was high degree of positive correlation between Information sharing and Management (r=0.746 whereas weak negative correlation on clarification and diagnosis (r=-0.011. Inter-rater correlation was established before hand and was satisfactory (p < 0.05. Conclusions This base line study of MD/MS residents shows that over all MD/MS residents are deficient in almost all the components of interpersonal communication skills. A communication skills training course in postgraduate medical education could improve the existing communication skills of the doctors in Nepal.

  9. Hybrid Pressure Retarded Osmosis−Membrane Distillation (PRO−MD) Process for Osmotic Power and Clean Water Generation

    KAUST Repository

    Han, Gang

    2015-05-20

    A novel pressure retarded osmosis−membrane distillation (PRO−MD) hybrid process has been experimentally conceived for sustainable production of renewable osmotic power and clean water from various waters. The proposed PRO−MD system may possess unique advantages of high water recovery rate, huge osmotic power generation, well controlled membrane fouling, and minimal environmental impacts. Experimental results show that the PRO−MD hybrid process is promising that not only can harvest osmotic energy from freshwater but also from wastewater. When employing a 2 M NaCl MD concentrate as the draw solution, ultrahigh power densities of 31.0 W/m2 and 9.3 W/m2 have been demonstrated by the PRO subsystem using deionized water and real wastewater brine as the feeds, respectively. Simultaneously, high purity potable water with a flux of 32.5−63.1 L/(m2.h) can be produced by the MD subsystem at 40−60 °C without any detrimental effects of fouling. The energy consumption in the MD subsystem might be further reduced by applying a heat exchanger in the hybrid system and using low-grade heat or solar energy to heat up the feed solution. The newly developed PRO−MD hybrid process would provide insightful guidelines for the exploration of alternative green technologies for renewable osmotic energy and clean water production.

  10. Validation of a short, qualitative food frequency questionnaire in French adults participating in the MONA LISA-NUT study 2005-2007.

    Science.gov (United States)

    Giovannelli, Jonathan; Dallongeville, Jean; Wagner, Aline; Bongard, Vanina; Laillet, Brigitte; Marecaux, Nadine; Ruidavets, Jean Bernard; Haas, Bernadette; Ferrieres, Jean; Arveiler, Dominique; Simon, Chantal; Dauchet, Luc

    2014-04-01

    Food frequency questionnaires (FFQs) are often used to evaluate individuals' food intakes in epidemiologic studies because of their simplicity and low cost. To assess the validity of a short (24 items), qualitative FFQ used in the MONA LISA-NUT study. Cross-sectional study of a representative sample in three French counties. The sample included 2,630 participants aged 35 to 65 years from the MONA LISA-NUT study. Food consumption was measured with the FFQ and via food records for 3 consecutive days. Plasma fatty acids were measured from a subset of participants. The FFQ items' validity was assessed by calculating crude and deattenuated Pearson correlation coefficients between frequencies reported by the FFQ and average weights reported by the food records. Furthermore, the validity of some items of the FFQ measuring the consumption of fatty foods was assessed by calculating Pearson correlation coefficients between frequencies of consumption of these foods and dosages of the corresponding plasma fatty acids: fish and eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), olive oil and oleic acid, margarine and elaidic acid, and dairy products and pentadecanoic and heptadecanoic acids. The mean of the deattenuated Pearson correlation coefficients for all items was 0.46, with values ranging from 0.22 (fried food) to 0.77 (breakfast cereal). The correlation coefficient was ≤ 0.4 for one third of the 24 items. Moderate correlations were found between fish and EPA/DHA (EPA: r=0.43, 95% CI 0.33 to 0.51; DHA: r=0.39, 95% CI 0.30 to 0.47), but not for other food items. One third of the 24 items in the short, qualitative FFQ evaluated here were not sufficiently valid. However, for the food groups most commonly studied in the literature, this FFQ had the same degree of validity as other questionnaires designed to classify subjects according to their level of intake. Copyright © 2014 Academy of Nutrition and Dietetics. Published by Elsevier Inc. All rights reserved.

  11. Hybrid Pressure Retarded Osmosis−Membrane Distillation (PRO−MD) Process for Osmotic Power and Clean Water Generation

    KAUST Repository

    Han, Gang; Zuo, Jian; Wan, Chunfeng; Chung, Neal Tai-Shung

    2015-01-01

    unique advantages of high water recovery rate, huge osmotic power generation, well controlled membrane fouling, and minimal environmental impacts. Experimental results show that the PRO−MD hybrid process is promising that not only can harvest osmotic

  12. A workshop on leadership for senior MD-PhD students.

    Science.gov (United States)

    Meador, Catherine B; Parang, Bobak; Musser, Melissa A; Haliyur, Rachana; Owens, David A; Dermody, Terence S

    2016-01-01

    Leadership skills are essential for a successful career as a physician-scientist, yet many MD-PhD training programs do not offer formal training in leadership. The Vanderbilt Medical Scientist Training Program (MSTP) previously established a 2-day leadership workshop that has been held biennially since 2006 for students in the first and second years of the graduate school portion of combined MD and PhD training (G1/G2 students). Workshop attendees have consistently rated this workshop as a highly effective experience. However, opportunities for structured training in leadership competencies during the subsequent 3-5 years of MD-PhD training are limited. Given the success of the G1/G2 leadership workshop and the need for continuity in this model of leadership training, we developed a half-day workshop for MSTP students in the clinical years of medical school (M3/M4 students) to foster continued training in leadership. Our workshop curriculum, based in part on original cases drafted by Vanderbilt MSTP students, provides concrete strategies to manage conflict and navigate leadership transitions in the physician-scientist career path. The curriculum emphasizes both short-term competencies, such as effective participation as a member of a clinical team, and long-term competencies, such as leadership of a research team, division, or department. Our inaugural senior leadership workshop, held in August, 2015, was judged by student participants to be well organized and highly relevant to leadership concepts and skills. It will be offered biennially in our training curriculum for M3 and M4 MSTP students.

  13. Property Analysis of Exfoliated Graphite Nanoplatelets Modified Asphalt Model Using Molecular Dynamics (MD Method

    Directory of Open Access Journals (Sweden)

    Hui Yao

    2017-01-01

    Full Text Available This Molecular Dynamics (MD simulation paper presents a physical property comparison study between exfoliated graphite nanoplatelets (xGNP modified and control asphalt models, including density, glass transition temperature, viscosity and thermal conductivity. The three-component control asphalt model consists of asphaltenes, aromatics, and saturates based on previous references. The xGNP asphalt model was built by incorporating an xGNP and control asphalt model and controlling mass ratios to represent the laboratory prepared samples. The Amber Cornell Extension Force Field (ACEFF was used with assigned molecular electro-static potential (ESP charge from NWChem analysis. After optimization and ensemble relaxation, the properties of the control and xGNP modified asphalt models were computed and analyzed using the MD method. The MD simulated results have a similar trend as the test results. The property analysis showed that: (1 the density of the xGNP modified model is higher than that of the control model; (2 the glass transition temperature of the xGNP modified model is closer to the laboratory data of the Strategic Highway Research Program (SHRP asphalt binders than that of the control model; (3 the viscosities of the xGNP modified model at different temperatures are higher than those of the control model, and it coincides with the trend in the laboratory data; (4 the thermal conductivities of the xGNP modified asphalt model are higher than those of the control asphalt model at different temperatures, and it is consistent with the trend in the laboratory data.

  14. MD study of pyrimidine base damage on DNA and its recognition by repair enzyme

    International Nuclear Information System (INIS)

    Pinak, M.

    2000-01-01

    The molecular dynamics (MD) simulation was used on the study of two specific damages of pyrimidine bases of DNA. Pyrimidine bases are major targets either of free radicals induced by ionizing radiation in DNA surrounding environment or UV radiation. Thymine dimer (TD) is UV induced damage, in which two neighboring thymines in one strand are joined by covalent bonds of C(5)-C(5) and C(6)-C(6) atoms of thymines. Thymine glycol (TG) is ionizing radiation induced damage in which the free water radical adds to unsaturated bond C(5)-C(6) of thymine. Both damages are experimentally suggested to be mutagenetic and carcinogenic unless properly repaired by repair enzymes. In the case of MD of TD, there is detected strong kink around the TD site that is not observed in native DNA. In addition there is observed the different value of electrostatic energy at the TD site - negative '-10 kcal/mol', in contrary to nearly neutral value of native thymine site. Structural changes and specific electrostatic energy - seems to be important for proper recognition of TD damaged site, formation of DNA-enzyme complex and thus for subsequent repair of DNA. In the case of TG damaged DNA there is major structural distortion at the TG site, mainly the increased distance between TG and the C5' of adjacent nucleotide. This enlarged gap between the neighboring nucleotides may prevent the insertion of complementary base during replication causing the replication process to stop. In which extend this structural feature together with energy properties of TG contributes to the proper recognition of TG by repair enzyme Endonuclease III is subject of further computational MD study. (author)

  15. Prediction of Osmotic Pressure of Ionic Liquids Inside a Nanoslit by MD Simulation and Continuum Approach

    Science.gov (United States)

    Moon, Gi Jong; Yang, Yu Dong; Oh, Jung Min; Kang, In Seok

    2017-11-01

    Osmotic pressure plays an important role in the processes of charging and discharging of lithium batteries. In this work, osmotic pressure of the ionic liquids confined inside a nanoslit is calculated by using both MD simulation and continuum approach. In the case of MD simulation, an ionic liquid is modeled as singly charged spheres with a short-ranged repulsive Lennard-Jones potential. The radii of the spheres are 0.5nm, reflecting the symmetry of ion sizes for simplicity. The simulation box size is 11nm×11nm×7.5nm with 1050 ion pairs. The concentration of ionic liquid is about 1.922mol/L, and the total charge on an individual wall varies from +/-60e(7.944 μm/cm2) to +/-600e(79.44 μm/cm2) . In the case of continuum approach, we classify the problems according to the correlation length and steric factor, and considered the four separate cases: 1) zero correlation length and zero steric factor, 2) zero correlation length and non-zero steric factor, 3) non-zero correlation length and zero steric factor, and 4) non-zero correlation and non-zero steric factor. Better understanding of the osmotic pressure of ionic liquids confined inside a nanoslit can be achieved by comparing the results of MD simulation and continuum approach. This research was supported by the National Research Foundation of Korea (NRF) Grant funded by the Korea government (MSIP: Ministry of Science, ICT & Future Planning) (No. 2017R1D1A1B05035211).

  16. Design and implementation of an ASIP-based cryptography processor for AES, IDEA, and MD5

    OpenAIRE

    Karim Shahbazi; Mohammad Eshghi; Reza Faghih Mirzaee

    2017-01-01

    In this paper, a new 32-bit ASIP-based crypto processor for AES, IDEA, and MD5 is designed. The instruction-set consists of both general purpose and specific instructions for the above cryptographic algorithms. The proposed architecture has nine function units and two data buses. It has also two types of 32-bit instruction formats for executing Memory Reference (M.R.), Register Reference (R.R.), and Input/Output Reference (I/O R.) instructions. The maximum achieved frequency is 166.916 MHz. T...

  17. A study on virtual source position for electron beams from a Mevatron MD linear accelerator

    International Nuclear Information System (INIS)

    Ravindran, B.P.

    1999-01-01

    The virtual source position (VSP) for electron beams of energies 5, 7, 9 10, 12 and 14 MeV and for the applicators (cones) available in the department have been measured for a Mevatron MD class linear accelerator. Different methods of obtaining the virtual source position for electron beams have been investigated in the present study. The results obtained have been compared with those of other workers. It is observed that the VSP is very much machine dependent and needs to be measured for each linear accelerator. The effect of shielding on virtual source position for the type of applicators available in the department has also been investigated. (author)

  18. Human microbiome science: vision for the future, Bethesda, MD, July 24 to 26, 2013

    Science.gov (United States)

    2014-01-01

    A conference entitled ‘Human microbiome science: Vision for the future’ was organized in Bethesda, MD from July 24 to 26, 2013. The event brought together experts in the field of human microbiome research and aimed at providing a comprehensive overview of the state of microbiome research, but more importantly to identify and discuss gaps, challenges and opportunities in this nascent field. This report summarizes the presentations but also describes what is needed for human microbiome research to move forward and deliver medical translational applications.

  19. Dynamics of biopolymers on nanomaterials studied by quasielastic neutron scattering and MD simulations

    Science.gov (United States)

    Dhindsa, Gurpreet K.

    Neutron scattering has been proved to be a powerful tool to study the dynamics of biological systems under various conditions. This thesis intends to utilize neutron scattering techniques, combining with MD simulations, to develop fundamental understanding of several biologically interesting systems. Our systems include a drug delivery system containing Nanodiamonds with nucleic acid (RNA), and two specific model proteins, beta-Casein and Inorganic Pyrophosphatase (IPPase). RNA and nanodiamond (ND) both are suitable for drug-delivery applications in nano-biotechnology. The architecturally flexible RNA with catalytic functionality forms nanocomposites that can treat life-threatening diseases. The non-toxic ND has excellent mechanical and optical properties and functionalizable high surface area, and thus actively considered for biomedical applications. In this thesis, we utilized two tools, quasielastic neutron scattering (QENS) and Molecular Dynamics Simulations to probe the effect of ND on RNA dynamics. Our work provides fundamental understanding of how hydrated RNA motions are affected in the RNA-ND nanocomposites. From the experimental and Molecular Dynamics Simulation (MD), we found that hydrated RNA motion is faster on ND surface than a freestanding one. MD Simulation results showed that the failure of Stokes Einstein relation results the presence of dynamic heterogeneities in the biomacromolecules. Radial pair distribution function from MD Simulation confirmed that the hydrophilic nature of ND attracts more water than RNA results the de-confinement of RNA on ND. Therefore, RNA exhibits faster motion in the presence of ND than freestanding RNA. In the second project, we studied the dynamics of a natively disordered protein beta-Casein which lacks secondary structures. In this study, the temperature and hydration effects on the dynamics of beta-Casein are explored by Quasielastic Neutron Scattering (QENS). We investigated the mean square displacement (MSD) of

  20. MD simulation: determination of the physical properties and surface vaporization analysis of beryllium armours

    International Nuclear Information System (INIS)

    Prinzio, M. Di; Aquaro, D.

    2006-01-01

    The erosion of the divertor and of the first wall determined on the base of the anticipated operating conditions, is a critical issue that could affect the performance and the operating schedule of the nuclear fusion reactor ITER. This paper deals with the analysis of beryllium thermal properties by means of MD simulations, in order to better predict thermal behaviour of beryllium armoured PFCs in fusion devices. The importance of this analysis is clearly connected to thermal response evaluation of PFCs to high heat flux exposure, during off-normal events and Edge Localized Modes. The ensuing strong over-heating, in fact, produces material ablation through vaporization of surface material layers and possible loss of melting material. The overall PFCs erosion has bearings on plasma contamination, due to eroded material transport, and components lifetime, due to armour thickness reduction. An important feature of beryllium is its high vapour pressure. During thermal transients the strong vaporization keeps surface temperature relatively low but eroded thickness results high as well. Small changes in beryllium vapour pressure produce not negligible differences in thermal analyses results. On the basis of available force fields, classical Molecular Dynamics simulations have been carried out in order to better understand surface vaporization in tokamak conditions and to evaluate the effect of beryllium oxides formation. This effect has been successfully modelled by MD simulation, carried out with Moldy code. Morse stretching and bending potential for Be-O bond simulation have been used, and partial charges method, accounting for molecular polarity, has been employed. Since during short thermal transients, such as ELMs, only a few microns of Be armour will be overheated and reach melting threshold, the effective thermal conductivity is very important in determining the temperature evolution of surface layers and the ensuing erosion. Thermal conductivity can be evaluated

  1. Report from LHC MD 2171: Amplitude dependent closest tune approach from normal and skew octupoles

    CERN Document Server

    Maclean, Ewen Hamish; Persson, Tobias Hakan Bjorn; Carlier, Felix Simon; CERN. Geneva. ATS Department

    2018-01-01

    Simulation-based studies predict significant amplitude-dependent closest tune approach can be generated by skew octupole sources in conjunction with their normal octupolar counterparts. This has the potential to significantly influence Landau damping at small β∗, where skew octupole errors in the experimental IRs, together with b4 introduced by the Landau octupoles, is predicted to cause large distortion of the tune footprint. This MD aimed to perform a first exploration of these predictions with beam, by enhancing skew octupole sources in the IRs at injection and measuring amplitude detuning with free kicks in the plane approaching the coupling resonance.

  2. Synergistic Applications of MD and NMR for the Study of Biological Systems

    Directory of Open Access Journals (Sweden)

    Olivier Fisette

    2012-01-01

    same time, theoretical and computational approaches gain in reliability and their field of application widens. In this short paper, we discuss recent advances in the areas of solution nuclear magnetic resonance (NMR spectroscopy and molecular dynamics (MD simulations that were made possible by the combination of both methods, that is, through their synergistic use. We present the main NMR observables and parameters that can be computed from simulations, and how they are used in a variety of complementary applications, including dynamics studies, model-free analysis, force field validation, and structural studies.

  3. Trap-efficiency investigation, Bernalillo Floodwater Retarding Reservoir No. 1 (Piedra Lisa Arroyo) near Bernalillo, New Mexico, water years 1956-1974

    Science.gov (United States)

    Funderburg, D.E.

    1977-01-01

    The U.S. Geological Survey, in cooperation with the U.S. Soil Conservation Service, began an investigation of sedimentation of Bernalillo Floodwater Retarding Reservoir No. 1 (Piedra Lisa Arroyo) near Bernalillo, New Mexico in 1956. This investigation was part of a nationwide investigation of the trap efficiency of detention reservoirs. Reservoirs No. 1 is normally a dry reservoir and runoff from the 10.6 sq km drainage area generally occurs from high-intensity summer thundershowers. The mesa area of the drainage basin was treated to prevent erosion and gullying and to retard rapid runoff of rainfall. The land treatment consisted of pits, terraces, seeding, and restricted grazing. The total outflow recorded for the period of record (July 19, 1956 to June 30, 1974) was 133 acre-feet, yielding 1 ,439 tons of sediment. Over 99 percent of the coarse sediments and a high percentage of the silts and clays were deposited in the reservoir before reaching the outflow pipe. The determined trap efficiency of Reservoir No. 1 was 96 percent for the period of record. (Woordard-USGS)

  4. Design and implementation of an ASIP-based cryptography processor for AES, IDEA, and MD5

    Directory of Open Access Journals (Sweden)

    Karim Shahbazi

    2017-08-01

    Full Text Available In this paper, a new 32-bit ASIP-based crypto processor for AES, IDEA, and MD5 is designed. The instruction-set consists of both general purpose and specific instructions for the above cryptographic algorithms. The proposed architecture has nine function units and two data buses. It has also two types of 32-bit instruction formats for executing Memory Reference (M.R., Register Reference (R.R., and Input/Output Reference (I/O R. instructions. The maximum achieved frequency is 166.916 MHz. The encoded output results of the encryption process of a 128-bit input block are obtained after 122, 146 and 170 clock cycles for AES-128, AES-192, and AES-256, respectively. Moreover, it takes 95 clock cycles to encrypt or decrypt a 64-bit input block by using IDEA. Finally, the MD5 hash algorithm requires 469 clock cycles to generate the coded outputs for a block of 512 bits. The performance of the proposed processor is compared to some previous and state-of-the-art implementations in terms of speed, latency, throughput, and flexibility.

  5. ComVisMD - compact visualization of multidimensional data: experimenting with cricket players data

    Science.gov (United States)

    Dandin, Shridhar B.; Ducassé, Mireille

    2018-03-01

    Database information is multidimensional and often displayed in tabular format (row/column display). Presented in aggregated form, multidimensional data can be used to analyze the records or objects. Online Analytical database Processing (OLAP) proposes mechanisms to display multidimensional data in aggregated forms. A choropleth map is a thematic map in which areas are colored in proportion to the measurement of a statistical variable being displayed, such as population density. They are used mostly for compact graphical representation of geographical information. We propose a system, ComVisMD inspired by choropleth map and the OLAP cube to visualize multidimensional data in a compact way. ComVisMD displays multidimensional data like OLAP Cube, where we are mapping an attribute a (first dimension, e.g. year started playing cricket) in vertical direction, object coloring based on b (second dimension, e.g. batting average), mapping varying-size circles based on attribute c (third dimension, e.g. highest score), mapping numbers based on attribute d (fourth dimension, e.g. matches played). We illustrate our approach on cricket players data, namely on two tables Country and Player. They have a large number of rows and columns: 246 rows and 17 columns for players of one country. ComVisMD’s visualization reduces the size of the tabular display by a factor of about 4, allowing users to grasp more information at a time than the bare table display.

  6. Characterization of Bitumen Micro-Mechanical Behaviors Using AFM, Phase Dynamics Theory and MD Simulation

    Directory of Open Access Journals (Sweden)

    Yue Hou

    2017-02-01

    Full Text Available Fundamental understanding of micro-mechanical behaviors in bitumen, including phase separation, micro-friction, micro-abrasion, etc., can help the pavement engineers better understand the bitumen mechanical performances at macroscale. Recent researches show that the microstructure evolution in bitumen will directly affect its surface structure and micro-mechanical performance. In this study, the bitumen microstructure and micro-mechanical behaviors are studied using Atomic Force Microscopy (AFM experiments, Phase Dynamics Theory and Molecular Dynamics (MD Simulation. The AFM experiment results show that different phase-structure will occur at the surface of the bitumen samples under certain thermodynamic conditions at microscale. The phenomenon can be explained using the phase dynamics theory, where the effects of stability parameter and temperature on bitumen microstructure and micro-mechanical behavior are studied combined with MD Simulation. Simulation results show that the saturates phase, in contrast to the naphthene aromatics phase, plays a major role in bitumen micro-mechanical behavior. A high stress zone occurs at the interface between the saturates phase and the naphthene aromatics phase, which may form discontinuities that further affect the bitumen frictional performance.

  7. Characterization of Bitumen Micro-Mechanical Behaviors Using AFM, Phase Dynamics Theory and MD Simulation.

    Science.gov (United States)

    Hou, Yue; Wang, Linbing; Wang, Dawei; Guo, Meng; Liu, Pengfei; Yu, Jianxin

    2017-02-21

    Fundamental understanding of micro-mechanical behaviors in bitumen, including phase separation, micro-friction, micro-abrasion, etc., can help the pavement engineers better understand the bitumen mechanical performances at macroscale. Recent researches show that the microstructure evolution in bitumen will directly affect its surface structure and micro-mechanical performance. In this study, the bitumen microstructure and micro-mechanical behaviors are studied using Atomic Force Microscopy (AFM) experiments, Phase Dynamics Theory and Molecular Dynamics (MD) Simulation. The AFM experiment results show that different phase-structure will occur at the surface of the bitumen samples under certain thermodynamic conditions at microscale. The phenomenon can be explained using the phase dynamics theory, where the effects of stability parameter and temperature on bitumen microstructure and micro-mechanical behavior are studied combined with MD Simulation. Simulation results show that the saturates phase, in contrast to the naphthene aromatics phase, plays a major role in bitumen micro-mechanical behavior. A high stress zone occurs at the interface between the saturates phase and the naphthene aromatics phase, which may form discontinuities that further affect the bitumen frictional performance.

  8. Using design science and artificial intelligence to improve health communication: ChronologyMD case example.

    Science.gov (United States)

    Neuhauser, Linda; Kreps, Gary L; Morrison, Kathleen; Athanasoulis, Marcos; Kirienko, Nikolai; Van Brunt, Deryk

    2013-08-01

    This paper describes how design science theory and methods and use of artificial intelligence (AI) components can improve the effectiveness of health communication. We identified key weaknesses of traditional health communication and features of more successful eHealth/AI communication. We examined characteristics of the design science paradigm and the value of its user-centered methods to develop eHealth/AI communication. We analyzed a case example of the participatory design of AI components in the ChronologyMD project intended to improve management of Crohn's disease. eHealth/AI communication created with user-centered design shows improved relevance to users' needs for personalized, timely and interactive communication and is associated with better health outcomes than traditional approaches. Participatory design was essential to develop ChronologyMD system architecture and software applications that benefitted patients. AI components can greatly improve eHealth/AI communication, if designed with the intended audiences. Design science theory and its iterative, participatory methods linked with traditional health communication theory and methods can create effective AI health communication. eHealth/AI communication researchers, developers and practitioners can benefit from a holistic approach that draws from theory and methods in both design sciences and also human and social sciences to create successful AI health communication. Copyright © 2013 Elsevier Ireland Ltd. All rights reserved.

  9. Alpha-gamma decay studies of 253No and its daughter products 253Md, 249Fm

    International Nuclear Information System (INIS)

    Hessberger, F.P.; Antalic, S.; Kalaninova, Z.; Saro, S.; Venhart, M.; Ackermann, D.; Heinz, S.; Kindler, B.; Kojouharov, I.; Kuusiniemi, P.; Lommel, B.; Mann, R.; Sulignano, B.; Hofmann, S.; Streicher, B.; Leino, M.; Nishio, K.

    2012-01-01

    Nuclear structure and decay of the isotope 253 No and its decay products 249 Fm and 253 Md were investigated by means of α - γ spectroscopy. Besides the established strong γ transitions from the 9/2 - [734] Nilsson level in 249 Fm, populated predominantly by the α decay of 253 No, into the ground-state (gs) rotational band, a couple of weaker γ lines (58.3, 129.2, 209.3 and 669.5keV) were observed and placed into the 249 Fm level scheme. The transition from the 7/2 - level in 249 Es, populated by the α decay of 253 Md, into the 9/2 + member of the gs rotational band, so far established for other odd-mass Es isotopes, was observed clearly. GEANT4 simulations were performed to investigate the influence of energy summing between α particles and conversion electrons (CE) on the shape of the α spectra at different implantation energies, leading to evidence for a weak α decay branch of 253 No into the gs of 249 Fm or the ground-state rotational band, respectively. (orig.)

  10. An apple B-box protein, MdCOL11, is involved in UV-B- and temperature-induced anthocyanin biosynthesis.

    Science.gov (United States)

    Bai, Songling; Saito, Takanori; Honda, Chikako; Hatsuyama, Yoshimichi; Ito, Akiko; Moriguchi, Takaya

    2014-11-01

    Our studies showed that an apple B-box protein, MdCOL11, the homolog of AtBBX22, is involved in UV-B- and temperature-induced anthocyanin biosynthesis in apple peel. Anthocyanin is responsible for the red pigmentation in apple peel and a R2R3 MYB gene, MdMYBA/1/10, a homolog of MdMYBA, controls its accumulation. Arabidopsis PAP1 is under the control of a series of upstream factors involved in light signal transduction and photomorphogenesis, such as ELONGATED HYPOCOTYL 5 (HY5) and B-box family (BBX) proteins. In this study, we identified and characterized the homolog of Arabidopsis BBX22 in apple, designated as MdCOL11. Overexpression of MdCOL11 in Arabidopsis enhanced the accumulation of anthocyanin. In apples, MdCOL11 was differentially expressed in all tissues, with the highest expression in petals and the lowest expression in the xylem. Transcripts of MdCOL11 noticeably accumulated at the ripening stage, concomitant with increases in the expressions of anthocyanin biosynthesis-related genes. In an in vitro treatment experiment, MdCOL11 was upregulated in an ultra-violet (UV)-B- and temperature-dependent manner, together with the inductions of anthocyanin biosynthesis-related genes and anthocyanin accumulation in apple peel. Furthermore, a dual-luciferase assay indicated that (1) MdCOL11 regulated the expression of MdMYBA and (2) MdCOL11 was a target of MdHY5. Taken together, our results suggest that MdCOL11 is involved in MdHY5-mediated signal transduction and regulates anthocyanin accumulation in apple peel, which sheds new light on anthocyanin accumulation in apples.

  11. An apple MYB transcription factor, MdMYB3, is involved in regulation of anthocyanin biosynthesis and flower development.

    Science.gov (United States)

    Vimolmangkang, Sornkanok; Han, Yuepeng; Wei, Guochao; Korban, Schuyler S

    2013-11-07

    Red coloration of fruit is an important trait in apple, and it is mainly attributed to the accumulation of anthocyanins, a class of plant flavonoid metabolites. Anthocyanin biosynthesis is genetically determined by structural and regulatory genes. Plant tissue pigmentation patterns are mainly controlled by expression profiles of regulatory genes. Among these regulatory genes are MYB transcription factors (TFs), wherein the class of two-repeats (R2R3) is deemed the largest, and these are associated with the anthocyanin biosynthesis pathway. Although three MdMYB genes, almost identical in nucleotide sequences, have been identified in apple, it is likely that there are other R2R3 MYB TFs that are present in the apple genome that are also involved in the regulation of coloration of red color pigmentation of the skin of apple fruits. In this study, a novel R2R3 MYB gene has been isolated and characterized in apple. This MYB gene is closely related to the Arabidopsis thaliana AtMYB3, and has been designated as MdMYB3. This TF belongs to the subgroup 4 R2R3 family of plant MYB transcription factors. This apple MdMYB3 gene is mapped onto linkage group 15 of the integrated apple genetic map. Transcripts of MdMYB3 are detected in all analyzed tissues including leaves, flowers, and fruits. However, transcripts of MdMYB3 are higher in excocarp of red-skinned apple cultivars than that in yellowish-green skinned apple cultivars. When this gene is ectopically expressed in Nicotiana tabacum cv. Petite Havana SR1, flowers of transgenic tobacco lines carrying MdMYB3 have exhibited increased pigmentation and accumulate higher levels of anthocyanins and flavonols than wild-type flowers. Overexpression of MdMYB3 has resulted in transcriptional activation of several flavonoid pathway genes, including CHS, CHI, UFGT, and FLS. Moreover, peduncles of flowers and styles of pistils of transgenic plants overexpressing MdMYB3 are longer than those of wild-type plants, thus suggesting that this

  12. Estimation of Hydrogen-Exchange Protection Factors from MD Simulation Based on Amide Hydrogen Bonding Analysis

    Science.gov (United States)

    Park, In-Hee; Venable, John D.; Steckler, Caitlin; Cellitti, Susan E.; Lesley, Scott A.; Spraggon, Glen; Brock, Ansgar

    2015-01-01

    Hydrogen exchange (HX) studies have provided critical insight into our understanding of protein folding, structure and dynamics. More recently, Hydrogen Exchange Mass Spectrometry (HX-MS) has become a widely applicable tool for HX studies. The interpretation of the wealth of data generated by HX-MS experiments as well as other HX methods would greatly benefit from the availability of exchange predictions derived from structures or models for comparison with experiment. Most reported computational HX modeling studies have employed solvent-accessible-surface-area based metrics in attempts to interpret HX data on the basis of structures or models. In this study, a computational HX-MS prediction method based on classification of the amide hydrogen bonding modes mimicking the local unfolding model is demonstrated. Analysis of the NH bonding configurations from Molecular Dynamics (MD) simulation snapshots is used to determine partitioning over bonded and non-bonded NH states and is directly mapped into a protection factor (PF) using a logistics growth function. Predicted PFs are then used for calculating deuteration values of peptides and compared with experimental data. Hydrogen exchange MS data for Fatty acid synthase thioesterase (FAS-TE) collected for a range of pHs and temperatures was used for detailed evaluation of the approach. High correlation between prediction and experiment for observable fragment peptides is observed in the FAS-TE and additional benchmarking systems that included various apo/holo proteins for which literature data were available. In addition, it is shown that HX modeling can improve experimental resolution through decomposition of in-exchange curves into rate classes, which correlate with prediction from MD. Successful rate class decompositions provide further evidence that the presented approach captures the underlying physical processes correctly at the single residue level. This assessment is further strengthened in a comparison of

  13. Structural and dynamical aspects of Streptococcus gordonii FabH through molecular docking and MD simulations.

    Science.gov (United States)

    Shamim, Amen; Abbasi, Sumra Wajid; Azam, Syed Sikander

    2015-07-01

    β-Ketoacyl-ACP-synthase III (FabH or KAS III) has become an attractive target for the development of new antibacterial agents which can overcome the multidrug resistance. Unraveling the fatty acid biosynthesis (FAB) metabolic pathway and understanding structural coordinates of FabH will provide valuable insights to target Streptococcus gordonii for curing oral infection. In this study, we designed inhibitors against therapeutic target FabH, in order to block the FAB pathway. As compared to other targets, FabH has more interactions with other proteins, located on the leading strand with higher codon adaptation index value and associated with lipid metabolism category of COG. Current study aims to gain in silico insights into the structural and dynamical aspect of S. gordonii FabH via molecular docking and molecular dynamics (MD) simulations. The FabH protein is catalytically active in dimerization while it can lock in monomeric state. Current study highlights two residues Pro88 and Leu315 that are close to each other by dimerization. The active site of FabH is composed of the catalytic triad formed by residues Cys112, His249, and Asn279 in which Cys112 is involved in acetyl transfer, while His249 and Asn279 play an active role in decarboxylation. Docking analysis revealed that among the studied compounds, methyl-CoA disulfide has highest GOLD score (82.75), binding affinity (-11 kcal/mol) and exhibited consistently better interactions. During MD simulations, the FabH structure remained stable with the average RMSD value of 1.7 Å and 1.6 Å for undocked protein and docked complex, respectively. Further, crucial hydrogen bonding of the conserved catalytic triad for exhibiting high affinity between the FabH protein and ligand is observed by RDF analysis. The MD simulation results clearly demonstrated that binding of the inhibitor with S. gordonii FabH enhanced the structure and stabilized the dimeric FabH protein. Therefore, the inhibitor has the potential to become

  14. Amniotic Fluid Soluble Myeloid Differentiation-2 (sMD-2) as Regulator of Intra-amniotic Inflammation in Infection-induced Preterm Birth.

    Science.gov (United States)

    Dulay, Antonette T; Buhimschi, Catalin S; Zhao, Guomao; Oliver, Emily A; Abdel-Razeq, Sonya S; Shook, Lydia L; Bahtiyar, Mert O; Buhimschi, Irina A

    2015-06-01

    TLR4 mediates host responses to pathogens through a mechanism that involves protein myeloid differentiation-2 (MD-2) and its soluble form sMD-2. The role of sMD2 in intra-amniotic inflammation-induced preterm birth has not been previously explored. Human amniotic fluid (AF) sMD-2 was studied by Western blotting in 152 AF samples of patients who had an amniocentesis to rule-out infection (yes infection, n = 50; no infection, n = 50) or women with normal pregnancy outcome (second trimester genetic karyotyping, n = 26; third trimester lung maturity testing, n = 26). Histological localization and mRNA expression of MD2 in fetal membranes were studied by immunohistochemistry and RT-PCR. The ability of fetal membrane to release sMD-2 and inflammatory cytokines was studied in vitro. Human AF contains three sMD-2 proteoforms whose levels of expression were lower at term. Intra-amniotic infection upregulated sMD-2. MD-2 mRNA and immunohistochemistry findings concurred. In vitro, LPS and monensin increased, while cycloheximide decreased sMD-2 production. Recombinant sMD-2 modulated TNF-α and IL-6 levels in a dose- and time-dependent fashion. sMD2 proteoforms are constitutively present in human AF. The intensity of the intra-amniotic inflammatory response to bacteria or perhaps to other TLR4 ligands may be facilitated through synthesis and release of sMD2 by the amniochorion. © 2015 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

  15. Prediction of drug-packaging interactions via molecular dynamics (MD) simulations.

    Science.gov (United States)

    Feenstra, Peter; Brunsteiner, Michael; Khinast, Johannes

    2012-07-15

    The interaction between packaging materials and drug products is an important issue for the pharmaceutical industry, since during manufacturing, processing and storage a drug product is continuously exposed to various packaging materials. The experimental investigation of a great variety of different packaging material-drug product combinations in terms of efficacy and safety can be a costly and time-consuming task. In our work we used molecular dynamics (MD) simulations in order to evaluate the applicability of such methods to pre-screening of the packaging material-solute compatibility. The solvation free energy and the free energy of adsorption of diverse solute/solvent/solid systems were estimated. The results of our simulations agree with experimental values previously published in the literature, which indicates that the methods in question can be used to semi-quantitatively reproduce the solid-liquid interactions of the investigated systems. Copyright © 2012 Elsevier B.V. All rights reserved.

  16. Samuel A. Mudd, MD, physician-farmer, University of Maryland School of Medicine class of 1856.

    Science.gov (United States)

    Harding, Richard K

    2012-12-01

    America is in the midst of experiencing the sesquicentennial of the Civil War. We do so with some ambivalence knowing that the war forged a great union and ended slavery but also caused the deaths of more than 600,000 fellow citizens. Samuel A. Mudd, MD, University of Maryland School of Medicine class of 1856, was a man of this time. As a physician-farmer in Southern Maryland, he was a highly respected physician, a slave owner, and a devout citizen. The Civil War (1861-1865) would alter his life in ways few could have imagined. This article looks at his background, his education, his work as a physician-farmer, and his dramatic rise to national attention and infamy. Convicted by a military tribunal and imprisoned for his "crimes," he was able to partially redeem himself using his medical skills and professionalism. Mudd was a man of his time. And what a time it was.

  17. Nanotribological behavior analysis of graphene/metal nanocomposites via MD simulations: New concepts and underlying mechanisms

    Science.gov (United States)

    Montazeri, A.; Mobarghei, A.

    2018-04-01

    In this article, we report a series of MD-based nanoindentation tests aimed to examine the nanotribological characteristics of metal-based nanocomposites in the presence of graphene sheets. To evaluate the effects of graphene/matrix interactions on the results, nickel and copper are selected as metals having strong and weak interactions with graphene, respectively. Consequently, the influence of graphene layers sliding and their distance from the sample surface on the nanoindentation outputs is thoroughly examined. Additionally, the temperature dependence of the results is deeply investigated with emphasis on the underlying mechanisms. To verify the accuracy of nanoindentation outputs, results of this method are compared with the data obtained via the tensile test. It is concluded that the nanoindentation results are closer to the values obtained by means of experimental setups. Employing these numerical-based experiments enables us to perform parametric studies to find out the dominant factors affecting the nanotribological behavior of these nanocomposites at the atomic-scale.

  18. A direct ab initio molecular dynamics (MD) study on the benzophenone-water 1 : 1 complex.

    Science.gov (United States)

    Tachikawa, Hiroto; Iyama, Tetsuji; Kato, Kohichi

    2009-07-28

    Direct ab initio molecular dynamics (MD) method has been applied to a benzophenone-water 1 : 1 complex Bp(H(2)O) and free benzophenone (Bp) to elucidate the effects of zero-point energy (ZPE) vibration and temperature on the absorption spectra of Bp(H(2)O). The n-pi transition of free-Bp (S(1) state) was blue-shifted by the interaction with a water molecule, whereas three pi-pi transitions (S(2), S(3) and S(4)) were red-shifted. The effects of the ZPE vibration and temperature of Bp(H(2)O) increased the intensity of the n-pi transition of Bp(H(2)O) and caused broadening of the pi-pi transitions. In case of the temperature effect, the intensity of n-pi transition increases with increasing temperature. The electronic states of Bp(H(2)O) were discussed on the basis of the theoretical results.

  19. MD421: Electron cloud studies on 25 ns beam variants (BCMS, 8b+4e)

    CERN Document Server

    Iadarola, Giovanni; Belli, Eleonora; Carver, Lee Robert; Dijkstal, Philipp; Li, Kevin Shing Bruce; Mether, Lotta; Romano, Annalisa; Rumolo, Giovanni; CERN. Geneva. ATS Department

    2017-01-01

    This note describes a Machine Development session performed with the main goal of studying the e-cloud mitigation that can be obtained by injecting mixed trains of 8b+4e beam type and trains having the standard 25 ns structure. Additionally, in the course of the MD, the pure 8b+4e beam was also checked to be stable when injected with low chromaticity and octupole current settings. Subsequently, the operational BCMS 25 ns beam was also injected with the 8b+4e settings and found to be unstable. The operational settings for injection were re-found by gradually increasing the chromaticity and octupole knobs until all the bunches of the injected beam could remain stable after injection.

  20. Accrediting the MD Programme in Sultan Qaboos University: Process, Earned Benefits, and Lessons Learned

    Directory of Open Access Journals (Sweden)

    Sulayma Albarwani

    2015-12-01

    Full Text Available The MD Programme of the College of Medicine and Health Sciences, Sultan Qaboos University, has been accredited recently. The College has been preparing for this event for more than ten years and wishes to share its experience with other regional medical colleges. The process of accreditation per se took less than three years to complete and most of the time was spent to prepare for the process; to build-up capacity in addition to implementing curricular reforms and other requirements that were needed to comply with accreditation standards. In the end of this exercise, the College has earned many benefits as well as learned some lessons. This article describes the most notable activities and events and discusses how the College responded to the challenges posed.