WorldWideScience

Sample records for mcsns localized regions

  1. Local, Regional or Global?

    DEFF Research Database (Denmark)

    Geisler Asmussen, Christian

    to be consistent with models of internationalization that incorporate different assumptions about strategic choice and global competition. Preliminary results show that large multinationals follow home region oriented internationalization paths, although much of the regional effect reported by previous studies...

  2. Global, Local, or Regional?

    DEFF Research Database (Denmark)

    Verbeke, Alain; Geisler Asmussen, Christian

    2016-01-01

    of analysis, in addition to the country-level and the global level. Regional strategy analysis requires a fundamental rethink of mainstream theories in the international strategy sphere. This rethink involves, inter alia, internalization theory, with its resource-based view and transaction cost economics...

  3. Regional power and local ecologies

    DEFF Research Database (Denmark)

    Lawrence, D.; Philip, G.; Wilkinson, K.

    2017-01-01

    Archaeological data tend to be gathered at the local level: human agency also operates at this scale. By combining data from multiple surveys conducted within a larger area, it is possible to use local datasets to obtain a perspective on regional trends in settlement, population, and human activity...... and climate are then examined side by side in order to assess long-term human interactions. Crown Copyright (C) 2015 Published by Elsevier Ltd. All rights reserved....

  4. Region effects influence local tree species diversity.

    Science.gov (United States)

    Ricklefs, Robert E; He, Fangliang

    2016-01-19

    Global patterns of biodiversity reflect both regional and local processes, but the relative importance of local ecological limits to species coexistence, as influenced by the physical environment, in contrast to regional processes including species production, dispersal, and extinction, is poorly understood. Failure to distinguish regional influences from local effects has been due, in part, to sampling limitations at small scales, environmental heterogeneity within local or regional samples, and incomplete geographic sampling of species. Here, we use a global dataset comprising 47 forest plots to demonstrate significant region effects on diversity, beyond the influence of local climate, which together explain more than 92% of the global variation in local forest tree species richness. Significant region effects imply that large-scale processes shaping the regional diversity of forest trees exert influence down to the local scale, where they interact with local processes to determine the number of coexisting species.

  5. Corruption, regionalization and local governance

    Directory of Open Access Journals (Sweden)

    Vuković Slobodan V.

    2002-01-01

    Full Text Available Corruption is old almost as human societies and it was developed simultaneously with enlargement of social and political power, bureaucracy and involvement of the state into market transactions. Specific conditions that are characteristic of Serbian society and that have favorably influenced the growth of corruption are: dissolution/break up of Yugoslavia war in surroundings, economic sanctions and NATO bombing. Besides these basic causes of corruption in Serbia are state control over the economy, lack of the rule of law, and breakdown of social values, that is, anomy and poverty. The lack of the rule of law and the state control of economy, which often occur together, are older conditions, while distorted social values, that is, moral crisis and poverty are newer. Subordination of judicial system to the executive authorities enabled different sorts of bribe and corruption to be tolerated. Therefore, the corruption has spread and became contemporary method of conducting business and almost a common thing, regardless of the party composition of the authorities. This thesis is confirmed by the empirical data: 17.9% of citizens claim that all local officials and corrupted and 48.4% claim that majority of them are. On the other side, only 27.5% of citizens claim that local party officials (all of them or majority accept bribe, and 31.1% claim that only some do. Therefore, we are faced with higher interest in political engagement, because it is becoming a highly profitable occupation and posts in local government are highly appreciated because corruption profit is calculated in advance.

  6. Localized scleroderma and regional inflammatory myopathy.

    Science.gov (United States)

    Zivković, Saša A; Freiberg, William; Lacomis, David; Domsic, Robyn T; Medsger, Thomas A

    2014-05-01

    Inflammatory myopathy is rare in localized scleroderma. We report 2 new cases of regional inflammatory myopathy associated with localized scleroderma and review 10 reported cases of localized scleroderma associated with an inflammatory myopathy with regional muscle involvement, more often in the upper extremities. Serum creatine kinase was mildly elevated or normal. Histopathology often showed perimysial inflammation and plasma cell infiltration. These cases demonstrate that inflammatory myopathy should be considered in patients with localized scleroderma and regional muscle weakness, pain or atrophy. Muscle biopsy can confirm the diagnosis of myositis, which if identified, will require anti-inflammatory and/or immunosuppressive therapy. Published by Elsevier B.V.

  7. Localized plexiform neurofibromatosis of the lumbar region

    Directory of Open Access Journals (Sweden)

    Chhang W

    1990-01-01

    Full Text Available A 13-year-old boy had a localized plexiform neurofibroma situated on a large cafe-au-lait spot in the lumbo-sacral region. Histopathology was characteristic, The result of surgical excision was satisfactory.

  8. Local/regional policies: Acting globally by thinking locally

    International Nuclear Information System (INIS)

    Hillsman, E.L.

    1991-01-01

    Policies to reduce greenhouse gas emissions from present levels will require changes in local and regional decision making as well as decisions made at national and multinational scales. A number of cities and states have taken action to reduce emissions either directly or as a byproduct of solving local problems such as air quality. These initiatives represent a potential resource to be mobilized in national policy. A series of case studies is under way to understand the decision making involved and its implications, and to identify ways that national policy might support and benefit from local efforts. Preliminary results from the first of these case studies indicate that reductions in greenhouse gas emissions may be greater when set as a direct target than when resulting as a byproduct of other local problem solving

  9. Local and regional greenhouse gas management

    International Nuclear Information System (INIS)

    Fleming, P.D.; Webber, P.H.

    2004-01-01

    This paper discusses the role of local government, working at both the local and regional level, to achieve substantial (greater than 20%) greenhouse gas emissions reductions. It identifies many different funding regimes and organisations supporting greenhouse gas emissions reductions and a lack of data with which to measure progress. The work in the East Midlands and in the City of Leicester are summarised and an evaluation of progress towards Leicester's target of 50% carbon dioxide (CO 2 ) emission reduction by 2025 based on 1990 is presented. Leicester's initiatives to reduce carbon emissions for the domestic and non-domestic sectors between 1996 and 1999 are analysed. Progress has been made in reducing the rate of rise in energy demand in Leicester and where energy efficiency activities have been concentrated, savings of 20-30% have been obtained. Significant CO 2 savings are achievable at the local and regional level, but the streamlining of support mechanisms for local authorities and a clearer national framework to support implementation are needed to enable all, rather than a few, UK local authorities to make progress

  10. Desarrollo multinivel: Implicaciones macro-regional, local y micro- regional

    Directory of Open Access Journals (Sweden)

    José Guadalupe Vargas Hernández

    2006-11-01

    Full Text Available Este trabajo se propone analizar las implicaciones del desarrollo en los niveles macro-regional, local y micro- regional, a partir de la hipótesis central de la teoría del desarrollo que plantea que el desarrollo económico traerá consigo el desarrollo político y social. Después de hacer de un acercamiento conceptual al desarrollo, se repasan brevemente las teorías del desarrollo existentes como herramientas de análisis de la realidad. En la discusión se concluye que los procesos de desarrollo locales y regionales requieren de una transformación sustancial de las relaciones negociadas entre los agentes económicos y los actores políticos. Ante el paulatino retroceso que en las sociedades contemporáneas está teniendo el Estado de bienestar, uno de los principales retos es el empoderamiento de las organizaciones sociales y comunitarias para que desempeñen activamente su rol en los procesos de desarrollo local y regional.

  11. Construction of local and regional identity

    Directory of Open Access Journals (Sweden)

    Georgia Butina Watson

    1997-01-01

    Full Text Available To many people’s deep regret, almost everywhere seems to be getting more and more like everywhere else. This problem is especially evident in new housing areas, frequently described as anonymous “anywhere” environments, lacking in any distinguishable character. The same criticism is applied to many shopping precincts and town centres where the long existing qualities of traditional townscapes are gradually being eroded. Since about 1970, there has been an increasing and widespread interest in ways of reversing this process. Architects, planners and urban designers have been searching for methods and design approaches in order to construct new local and regional identity and create places to be proud of because of their unique character. Different theoretical schools have put forward their own methodological propositions, evidence of which can be found in many urban design and architectural schemes across many continents and cultural regions. Of particular interest to architects and urban designers today is the ability to use and appropriate methodologies already developed and tested through built projects.

  12. Disturbance alters local-regional richness relationships in appalachian forests

    Science.gov (United States)

    Belote, R.T.; Sanders, N.J.; Jones, R.H.

    2009-01-01

    Whether biological diversity within communities is limited by local interactions or regional species pools remains an important question in ecology. In this paper, we investigate how an experimentally applied tree-harvesting disturbance gradient influenced local-regional richness relationships. Plant species richness was measured at three spatial scales (2 ha = regional; 576 m2 and 1 m2 = local) on three occasions (one year pre-disturbance, one year post-disturbance, and 10 years post-disturbance) across five disturbance treatments (uncut control through clearcut) replicated throughout the southern Appalachian Mountains, USA. We investigated whether species richness in 576-m2 plots and 1-m2 subplots depended on species richness in 2-ha experimental units and whether this relationship changed through time before and after canopy disturbance. We found that, before disturbance, the relationship between local and regional richness was weak or nonexistent. One year after disturbance local richness was a positive function of regional richness, because local sites were colonized from the regional species pool. Ten years after disturbance, the positive relationship persisted, but the slope had decreased by half. These results suggest that disturbance can set the stage for strong influences of regional species pools on local community assembly in temperate forests. However, as time since disturbance increases, local controls on community assembly decouple the relationships between regional and local diversity. ?? 2009 by the Ecological Society of America.

  13. Local and regional low carbon scenarios methodology, challenges and opportunities

    International Nuclear Information System (INIS)

    2010-01-01

    In its first part, this report discusses the emergence of local climate and energy policy in Europe, the implementation of nationally imposed but regionally anchored energy scenarios (i.e. in France, the Climate Air Energy Regional Schemes or SRCAE). Then it addresses the methodological and political aspects of local and regional low emission scenarios: methodologies and typologies of energy scenarios, ways to define an appropriate emission reduction and energy consumption objective, ways to deal with emission or carbon gaps, ways to make local emission inventories, ways to gather local data, ways to deal with special emission sources, ways to assess and develop local energy efficiency and renewable energy potentials, ways to take energy sufficiency into account, and the evolution from energy autonomy to 100% renewable energy territories. The last part addresses the issues of stake holder and citizen participation in the definition of long term strategies

  14. Regional reanalysis without local data: Exploiting the downscaling paradigm

    Science.gov (United States)

    von Storch, Hans; Feser, Frauke; Geyer, Beate; Klehmet, Katharina; Li, Delei; Rockel, Burkhardt; Schubert-Frisius, Martina; Tim, Nele; Zorita, Eduardo

    2017-08-01

    This paper demonstrates two important aspects of regional dynamical downscaling of multidecadal atmospheric reanalysis. First, that in this way skillful regional descriptions of multidecadal climate variability may be constructed in regions with little or no local data. Second, that the concept of large-scale constraining allows global downscaling, so that global reanalyses may be completed by additions of consistent detail in all regions of the world. Global reanalyses suffer from inhomogeneities. However, their large-scale componenst are mostly homogeneous; Therefore, the concept of downscaling may be applied to homogeneously complement the large-scale state of the reanalyses with regional detail—wherever the condition of homogeneity of the description of large scales is fulfilled. Technically, this can be done by dynamical downscaling using a regional or global climate model, which's large scales are constrained by spectral nudging. This approach has been developed and tested for the region of Europe, and a skillful representation of regional weather risks—in particular marine risks—was identified. We have run this system in regions with reduced or absent local data coverage, such as Central Siberia, the Bohai and Yellow Sea, Southwestern Africa, and the South Atlantic. Also, a global simulation was computed, which adds regional features to prescribed global dynamics. Our cases demonstrate that spatially detailed reconstructions of the climate state and its change in the recent three to six decades add useful supplementary information to existing observational data for midlatitude and subtropical regions of the world.

  15. Regional legislation in Italy for the protection of local varieties

    Directory of Open Access Journals (Sweden)

    Enrico Bertacchini

    2011-11-01

    Full Text Available This article analyses the consequences of regional legislation in Italy on protecting local and autochthonous varieties. In accordance with the objectives of the FAO treaty on plant genetic resources (ITPGRFA, these laws have emerged as one of the most interesting institutional attempts at Italian and European level towards enhancing and protecting agricultural biodiversity. A description of the regional laws and their implementation highlights the importance of supporting farming systems that are close relationship with the territory and local communities, creating sufficient juridical space for the varieties that are not part of the ‘formal’ seed system.

  16. Regional Autonomy and Local Democracy: Independent Candidates Cases

    Directory of Open Access Journals (Sweden)

    Suryanto

    2016-11-01

    Full Text Available One of the efforts to achieve local democracy is through the participation of independent candidates in the Direct General Election in the region. The presence of independent candidates in the Direct General Election gives a great hope to change the political structure of the shackles of the old forces. This paper aims to discuss the implication of regional heads coming from independent candidates on the effectiveness of local governance and the implementation of substantive democracy in the region. The method used is a qualitative approach using descriptive research method. The data collection is done through literature approach. Processing data uses Milles and Huberman interactive models, which includes data reduction, data presentation, and conclusion. The study concluded three things: First, the presence of independent candidates in the Direct General Election gives the opportunities to achieve local democracy that is getting bigger, Second, Regional Heads elected from independent candidates face the challenges of the ineffectiveness of regional government, and Third, within certain limits, the power of elected regional heads from independent lane leads to the realization of democracy that is not substantial.

  17. Locally specific measures for employment aimed at regional development

    Directory of Open Access Journals (Sweden)

    Vladimir Cini

    2013-12-01

    Full Text Available The oldest and largest sub-region in the world functioning on the principle of economic union is the European Union. The creation of a single market has initiated the process of conditional adjustment of markets in the EU member states, which has a significant impact on the social welfare of its citizens. It is necessary to tackle this issue by joint efforts within the European Union. As globalization processes push for economic integration and development of competitive advantage, the regions will have to make some challenging adjustments. The development tends to concentrate in highly competitive regions, while regions in the periphery lag behind. However, this pertains not only to the economic lag, but also to a potential negative political situation. Locally specific active employment policy measures are a continuation of the effort to make these measures more flexible. They refer to the Joint Assessment of Employment Policy Priorities and the IPA Human Resources Development Operational Programme - a regional policy instrument of the European Union. Both documents highlight the issue of disproportional development of regions, which requires special local measures and active labour market policy programmes. To reduce regional differences in development, it is necessary to invest more resources in the regions that lag behind. In this particular case, this means the counties in Croatia with high unemployment rates, a large number of registered unemployed persons and low employment rate. Consequently, this paper explains the importance of the adoption of locally specific measures for employment, which unfortunately did not take hold in the Republic of Croatia, and highlights the need for further decentralization of public services, with the aim of balancing regional development

  18. VCE Model of Community, Local, Regional Food Systems

    OpenAIRE

    Niewolny, Kim

    2016-01-01

    This document is a chart illustrating the Virginia Cooperative Extension model for food systems at the community, local and regional level. This chart shows an interrelationship between basic and applied research, leveraging of resources and opportunities, communication and marketing, assessment, evaluation and impact, knowledge, skills, and social change, facilitation of partnerships, and also teaching.

  19. [The contributions of local authorities to regional public health policy].

    Science.gov (United States)

    de Maria, Florence; Grémy, Isabelle

    2009-01-01

    Local authorities in France are key players in shaping public health policy by their action on the determinants of health and through their actions aimed at specific population groups. Since the public health act of 9 August 2004 establishing the first regional public health plans, their level of involvement and role continues to grow as coordinators, funders and project managers within the greater Paris metropolitan region. Their active participation in regional policy to improve population health and reduce inequalities in health has led to a better organization of the public health programs implemented (in terms of visibility, dialogue, coordination, transparency, and better awareness of context and integration of local issues). Their participation is also a source of innovation resulting in the proposal and use of new approaches (such as the development of health surveillance and observation for advising the local decision-making process). Within the current context of the "Hospitals, patients, health and territories" bill, which entrusts the governance of regional health policy to a specific agency, the role given to local authorities in this new organizational structure must be clearly defined to take into account all of their existing and potential contributions to public health policy.

  20. Local and Regional Spread of Primary Conjunctival Squamous Cell Carcinoma.

    Science.gov (United States)

    Desai, Shilpa J; Pruzan, Noelle L; Geske, Michael J; Jeng, Bennie H; Bloomer, Michele M; Vagefi, M Reza

    2016-04-06

    Two cases of biopsy-proven conjunctival squamous cell carcinoma (SCC) that developed local and regional spread are described. The cases involved a 65-year-old woman and a 79-year-old man who were initially treated at outside institutions for SCC of the conjunctiva. The patients did not have a history of immune compromise. The female patient presented with direct extension into the lacrimal gland but deferred recommended exenteration. Despite eventual exenteration, she developed metastasis to a neck node 6 months later, which was treated with radiotherapy. The male patient presented with local recurrence and a parotid node metastasis treated with exenteration, parotidectomy, selective neck dissection, and postoperative radiotherapy. Review of the outside pathology of both cases revealed positive tumor margins at the time of original resection. Local control of conjunctival SCC is of critical importance to reduce the risk of orbital extension and regional spread.

  1. Deposition and erosion in local shadow regions of TEXTOR-94

    International Nuclear Information System (INIS)

    Wienhold, P.; Mayer, M.; Kirschner, A.; Rubel, M.; Hildebrandt, D.; Schneider, W.

    2001-01-01

    Carbon erosion and deposition were investigated on the surface of a flat target covered with an a-C:H film and exposed for 197 s in the SOL of TEXTOR-94. The target was declined by 20 with respect to the toroidal direction and partly protected by an aluminum (3 mm) plate which created an 8 mm wide local shadow. Thickness changes were measured by colorimetry after each plasma discharge. Carbon is eroded from surface areas near the plasma edge (LCFS +1 cm) and transported into the local shadow regions. Accumulation rates up to ∼7 nm/s were found. The erosion in the local shadow regions (about -0.1 nm/s) is due to charge exchange neutrals. The observations are confirmed by ion beam analyses and by preliminary calculations with the B2-EIRENE and ERO-TEXTOR code. (orig.)

  2. Controversies regarding decentralism, regionalism, and local governance in Serbia

    Directory of Open Access Journals (Sweden)

    Mitrović Milovan M.

    2002-01-01

    Full Text Available The article is composed from three parts. In the first part, I emphasize the importance of theoretical and sociological discussion for the design of the model of social system reforms and stress the problems that occur in Serbia with regard to this. In the second part, I discuss public controversies regarding decentralism, regionalism, and local governance in Serbia. I advocate for regionalism that is closer to local then to para-state governance and argue for the advantages of alternative model of 'functional autonomy of different tempo', that could harmonize inherited historical geopolitical, economic, and cultural differences and reconcile current political antagonisms in Serbia. In the third part I give a proposition that envisages central (Republic administration and local (municipal and city self-governance as main levels of territorial organization of governance (with original authorities, while federal and regional levels would be complementary with it, not parallel. In that sense, I propose 15 autonomous regions for Serbia, with possibility of making 4 to 6 larger regions out of them, at different pace.

  3. Local magnitude scale for Valle Medio del Magdalena region, Colombia

    Science.gov (United States)

    Londoño, John Makario; Romero, Jaime A.

    2017-12-01

    A local Magnitude (ML) scale for Valle Medio del Magdalena (VMM) region was defined by using 514 high quality earthquakes located at VMM area and inversion of 2797 amplitude values of horizontal components of 17 stations seismic broad band stations, simulated in a Wood-Anderson seismograph. The derived local magnitude scale for VMM region was: ML =log(A) + 1.3744 ∗ log(r) + 0.0014776 ∗ r - 2.397 + S Where A is the zero-to-peak amplitude in nm in horizontal components, r is the hypocentral distance in km, and S is the station correction. Higher values of ML were obtained for VMM region compared with those obtained with the current formula used for ML determination, and with California formula. With this new scale ML values are adjusted to local conditions beneath VMM region leading to more realistic ML values. Moreover, with this new ML scale the seismicity caused by tectonic or fracking activity at VMM region can be monitored more accurately.

  4. Integration of Local Hydrology into Regional Hydrologic Simulation Model

    Science.gov (United States)

    Van Zee, R. J.; Lal, W. A.

    2002-05-01

    South Florida hydrology is dominated by the Central and South Florida (C&SF) Project that is managed to provide flood protection, water supply and environmental protection. A complex network of levees canals and structures provide these services to the individual drainage basins. The landscape varies widely across the C&SF system, with corresponding differences in the way water is managed within each basin. Agricultural areas are managed for optimal crop production. Urban areas maximize flood protection while maintaining minimum water levels to protect adjacent wetlands and local water supplies. "Natural" areas flood and dry out in response to the temporal distribution of rainfall. The evaluation of planning, regulation and operational issues require access to a simulation model that captures the effects of both regional and local hydrology. The Regional Simulation Model (RSM) uses a "pseudo-cell" approach to integrate local hydrology within the context of a regional hydrologic system. A 2-dimensional triangulated mesh is used to represent the regional surface and ground water systems and a 1-dimensional canal network is superimposed onto this mesh. The movement of water is simulated using a finite volume formulation with a diffusive wave approximation. Each cell in the triangulated mesh has a "pseudo-cell" counterpart, which represents the same area as the cell, but it is conceptualized such that it simulates the localized hydrologic conditions Protocols have been established to provide an interface between a cell and its pseudo-cell counterpart. . A number of pseudo-cell types have already been developed and tested in the simulation of Water Conservation Area 1 and several have been proposed to deal with specific local issues in the Southwest Florida Feasibility Study. This presentation will provide an overview of the overall RSM design, describe the relationship between cells and pseudo-cells, and illustrate how pseudo-cells are be used to simulate agriculture

  5. Regional versus local influences on lead and cadmium loading to the Great Lakes region

    Energy Technology Data Exchange (ETDEWEB)

    Yohn, S.; Long, D.; Fett, J.; Patino, L. [Michigan State University, East Lansing, MI (United States). Dept. of Geological Science

    2004-07-01

    Environmental legislation has reduced the anthropogenic loadings of Pb and Cd to the Great Lakes region over the past 3 decades. However, the accumulation rates of these metals still remain above background values. Because environmental legislation was targeted at major sources (e.g., Pb in gasoline) whose influence on the environment was on a regional scale, local sources (e.g., watershed scale) for the metals may now play a more significant role. The relative importance of regional versus local scale influences on metal inputs to the environment is poorly understood. In this study, sediment chronologies of Pb and Cd were examined from 12 inland lakes that cover the broad geographic area of the State of Michigan. These chronologies were compared temporally and spatially and to watershed population densities and metal production records to gain an understanding of local and regional influences on metal inputs to the Great Lakes region. Results show that anthropogenic Pb loading during the 1930s and 1970s was dominated by regional sources. such as coal burning and use of leaded gasoline. Current loadings are now more related to local influences such as watershed population densities, rather than atmospheric deposition. Anthropogenic Cd loadings to the Great Lakes region have been dominated by both regional and local sources over time. Lead may also have shown the influence of local sources over time, if the influence of emissions from gasoline had not been present. This work shows that Pb and Cd loadings in the Great Lakes region are strongly related to watershed population densities; however, the specific sources and pathways for the metal cycling are unclear.

  6. Deriving local demand for stumpage from estimates of regional supply and demand.

    Science.gov (United States)

    Kent P. Connaughton; Gerard A. Majerus; David H. Jackson

    1989-01-01

    The local (Forest-level or local-area) demand for stumpage can be derived from estimates of regional supply and demand. The derivation of local demand is justified when the local timber economy is similar to the regional timber economy; a simple regression of local on nonlocal prices can be used as an empirical test of similarity between local and regional economies....

  7. Local Helioseismology of Emerging Active Regions: A Case Study

    Science.gov (United States)

    Kosovichev, Alexander G.; Zhao, Junwei; Ilonidis, Stathis

    2018-04-01

    Local helioseismology provides a unique opportunity to investigate the subsurface structure and dynamics of active regions and their effect on the large-scale flows and global circulation of the Sun. We use measurements of plasma flows in the upper convection zone, provided by the Time-Distance Helioseismology Pipeline developed for analysis of solar oscillation data obtained by Helioseismic and Magnetic Imager (HMI) on Solar Dynamics Observatory (SDO), to investigate the subsurface dynamics of emerging active region NOAA 11726. The active region emergence was detected in deep layers of the convection zone about 12 hours before the first bipolar magnetic structure appeared on the surface, and 2 days before the emergence of most of the magnetic flux. The speed of emergence determined by tracking the flow divergence with depth is about 1.4 km/s, very close to the emergence speed in the deep layers. As the emerging magnetic flux becomes concentrated in sunspots local converging flows are observed beneath the forming sunspots. These flows are most prominent in the depth range 1-3 Mm, and remain converging after the formation process is completed. On the larger scale converging flows around active region appear as a diversion of the zonal shearing flows towards the active region, accompanied by formation of a large-scale vortex structure. This process occurs when a substantial amount of the magnetic flux emerged on the surface, and the converging flow pattern remains stable during the following evolution of the active region. The Carrington synoptic flow maps show that the large-scale subsurface inflows are typical for active regions. In the deeper layers (10-13 Mm) the flows become diverging, and surprisingly strong beneath some active regions. In addition, the synoptic maps reveal a complex evolving pattern of large-scale flows on the scale much larger than supergranulation

  8. Abnormalities by pulmonary regions studied with computer tomography following local or local-regional radiotherapy for breast cancer

    International Nuclear Information System (INIS)

    Lind, Pehr; Svane, Gunilla; Gagliardi, Giovanna; Svensson, Christer

    1999-01-01

    Purpose: To study pulmonary radiological abnormalities with computer tomography (CT) following different radiotherapy (RT) techniques for breast cancer with respect to regions and density, and their correlation to pulmonary complications and reduction in vital capacity (VC). Methods and Materials: CT scans of the lungs were performed prior to and 4 months following RT in 105 breast cancer patients treated with local or local-regional RT. The radiological abnormalities were analyzed with a CT-adapted modification of a classification system originally proposed by Arriagada, and scored according to increasing density (0-3) and affected lung regions (apical-lateral, central-parahilar, basal-lateral). The highest density grade in each region were added together to form scores ranging from 0-9. The patients were monitored for RT-induced pulmonary complications. VC was measured prior to and 5 months following RT. Results: Increasing CT scores were correlated with both local-regional RT and pulmonary complications (p < 0.001). The mean reduction of VC for patients scoring 4-9 (-202 ml) was larger than for patients scoring 0-3 (-2 ml) (p = 0.035). The effect of confounding factors on the radiological scoring was tested in the local-regional RT group. Scores of 4-9 were less frequently seen in the patients who had received adjuvant chemotherapy prior to RT. The importance of the respective lung regions on the outcome of pulmonary complications was tested. Only radiological abnormalities in the central-parahilar and apical-lateral regions were significantly correlated to pulmonary complications. Discussion: Radiological abnormalities detected on CT images and scored with a modification of Arriagada's classification system can be used as an objective endpoint for pulmonary side effects in breast cancer. The described model should, however, be expanded with information about the volume of lung affected in each region before definite conclusions can be drawn concerning each

  9. Regional Innovation System And Local Economic Development In Indonesia

    Directory of Open Access Journals (Sweden)

    Adiwan F Aritenang

    2013-08-01

    Full Text Available In Indonesia, decentralization and globalization has introduced a new spirit for localism. Since decentralisation, regions have been motivated to accelerate economic development through local endowment and resources. The democratic Indonesia government has been interested to follow economy theories and case studies develop in the advance countries. Over the years, government policies have supported and strengthen technology development through industrial clusters and national and regional innovation systems. This research aims to explore current progress of Indonesia innovation system through industrial clusters. The research found the presence of industry clustering and very limited innovation system in Indonesia. The research argues that these activities has significant impact on employment growth, but does not increase the industry's value added.

  10. Meteorological Controls on Local and Regional Volcanic Ash Dispersal.

    Science.gov (United States)

    Poulidis, Alexandros P; Phillips, Jeremy C; Renfrew, Ian A; Barclay, Jenni; Hogg, Andrew; Jenkins, Susanna F; Robertson, Richard; Pyle, David M

    2018-05-02

    Volcanic ash has the capacity to impact human health, livestock, crops and infrastructure, including international air traffic. For recent major eruptions, information on the volcanic ash plume has been combined with relatively coarse-resolution meteorological model output to provide simulations of regional ash dispersal, with reasonable success on the scale of hundreds of kilometres. However, to predict and mitigate these impacts locally, significant improvements in modelling capability are required. Here, we present results from a dynamic meteorological-ash-dispersion model configured with sufficient resolution to represent local topographic and convectively-forced flows. We focus on an archetypal volcanic setting, Soufrière, St Vincent, and use the exceptional historical records of the 1902 and 1979 eruptions to challenge our simulations. We find that the evolution and characteristics of ash deposition on St Vincent and nearby islands can be accurately simulated when the wind shear associated with the trade wind inversion and topographically-forced flows are represented. The wind shear plays a primary role and topographic flows a secondary role on ash distribution on local to regional scales. We propose a new explanation for the downwind ash deposition maxima, commonly observed in volcanic eruptions, as resulting from the detailed forcing of mesoscale meteorology on the ash plume.

  11. Exposing region duplication through local geometrical color invariant features

    Science.gov (United States)

    Gong, Jiachang; Guo, Jichang

    2015-05-01

    Many advanced image-processing softwares are available for tampering images. How to determine the authenticity of an image has become an urgent problem. Copy-move is one of the most common image forgery operations. Many methods have been proposed for copy-move forgery detection (CMFD). However, most of these methods are designed for grayscale images without any color information used. They are usually not suitable when the duplicated regions have little structure or have undergone various transforms. We propose a CMFD method using local geometrical color invariant features to detect duplicated regions. The method starts by calculating the color gradient of the inspected image. Then, we directly take the color gradient as the input for scale invariant features transform (SIFT) to extract color-SIFT descriptors. Finally, keypoints are matched and clustered before their geometrical relationship is estimated to expose the duplicated regions. We evaluate the detection performance and computational complexity of the proposed method together with several popular CMFD methods on a public database. Experimental results demonstrate the efficacy of the proposed method in detecting duplicated regions with various transforms and poor structure.

  12. Does FDI promote regional development? Evidence from local and regional productivity spillovers in Greece

    Directory of Open Access Journals (Sweden)

    Vassilis MONASTIRIOTIS

    2010-12-01

    Full Text Available Studies on the productivity spillovers of FDI have concentrated on the nationalsectoral level. As a result, little is known about the impact of FDI on absolute and relative regional economic performance. In this paper we examine this issue by relying on a unique dataset of over 20,000 Greek firms for the period 2002-2006 covering all sectors of economic activity. We examine the spatial distribution of foreign-owned firms in the country and analyse the effect that their presence – at the local, regional and national levels – has on the productivity of domestic firms. We find strong evidence suggesting that foreignowned firms self-select into regions and sectors of high productivity. Net of this selection effect, the impact of foreign presence on domestic productivity is negative – although at the very local level some positive spillover effects are identifiable. The bulk of the effects concentrate in non-manufacturing activities, high-tech sectors, and medium-sized high-productivity firms. Importantly, this effect is not constant across space however. Productivity spillovers tend to be negative in the regions hosting the main urban areas in the country but positive in smaller and more peripheral regions. In this way, despite the tendency of FDI to concentrate in a limited number of areas within the country – those of the highest level of development – the externalities that FDI activity generates to the local economies appear to be of a rather equilibrating character.

  13. Local population and regional environmental drivers of cholera in Bangladesh

    Directory of Open Access Journals (Sweden)

    Escamilla Veronica

    2010-01-01

    Full Text Available Abstract Background Regional environmental factors have been shown to be related to cholera. Previous work in Bangladesh found that temporal patterns of cholera are positively related to satellite-derived environmental variables including ocean chlorophyll concentration (OCC. Methods This paper investigates whether local socio-economic status (SES modifies the effect of regional environmental forces. The study area is Matlab, Bangladesh, an area of approximately 200,000 people with an active health and demographic surveillance system. Study data include (1 spatially-referenced demographic and socio-economic characteristics of the population; (2 satellite-derived variables for sea surface temperature (SST, sea surface height (SSH, and OCC; and (3 laboratory confirmed cholera case data for the entire population. Relationships between cholera, the environmental variables, and SES are measured using generalized estimating equations with a logit link function. Additionally two separate seasonal models are built because there are two annual cholera epidemics, one pre-monsoon, and one post-monsoon. Results SES has a significant impact on cholera occurrence: the higher the SES score, the lower the occurrence of cholera. There is a significant negative association between cholera incidence and SSH during the pre-monsoon period but not for the post-monsoon period. OCC is positively associated with cholera during the pre-monsoon period but not for the post-monsoon period. SST is not related to cholera incidence. Conclusions Overall, it appears cholera is influenced by regional environmental variables during the pre-monsoon period and by local-level variables (e.g., water and sanitation during the post-monsoon period. In both pre- and post-monsoon seasons, SES significantly influences these patterns, likely because it is a proxy for poor water quality and sanitation in poorer households.

  14. Regional aerosol emissions and temperature response: Local and remote climate impacts of regional aerosol forcing

    Science.gov (United States)

    Lewinschal, Anna; Ekman, Annica; Hansson, Hans-Christen

    2017-04-01

    Emissions of anthropogenic aerosols vary substantially over the globe and the short atmospheric residence time of aerosols leads to a highly uneven radiative forcing distribution, both spatially and temporally. Regional aerosol radiative forcing can, nevertheless, exert a large influence on the temperature field away from the forcing region through changes in heat transport or the atmospheric or ocean circulation. Moreover, the global temperature response distribution to aerosol forcing may vary depending on the geographical location of the forcing. In other words, the climate sensitivity in one region can vary depending on the location of the forcing. The surface temperature distribution response to changes in sulphate aerosol forcing caused by sulphur dioxide (SO2) emission perturbations in four different regions is investigated using the Norwegian Earth System Model (NorESM). The four regions, Europe, North America, East and South Asia, are all regions with historically high aerosol emissions and are relevant from both an air-quality and climate policy perspective. All emission perturbations are defined relative to the year 2000 emissions provided for the Coupled Model Intercomparison Project phase 5. The global mean temperature change per unit SO2 emission change is similar for all four regions for similar magnitudes of emissions changes. However, the global temperature change per unit SO2 emission in simulations where regional SO2 emission were removed is substantially higher than that obtained in simulations where regional SO2 emissions were increased. Thus, the climate sensitivity to regional SO2 emissions perturbations depends on the magnitude of the emission perturbation in NorESM. On regional scale, on the other hand, the emission perturbations in different geographical locations lead to different regional temperature responses, both locally and in remote regions. The results from the model simulations are used to construct regional temperature potential

  15. Assessment of local and regional isotopic equilibrium in the mantle

    Energy Technology Data Exchange (ETDEWEB)

    Hofmann, A W; Hart, S R [Carnegie Institution of Washington, D.C. (USA). Dept. of Terrestrial Magnetism

    1978-02-01

    The assumption of local equilibrium during partial melting is fundamental to the interpretation of isotope and trace element data for mantle-derived rocks. If disequilibrium melting is significant, the scale of the chemical and isotopic heterogeneity in the mantle indicated by the data could be as small as the grain size of the mantle rock, and the isotope data themselves are then of doubtful value to the understanding of mantle processes. To assess the scale of isotopic heterogeneity in a partially molten asthenosphere the authors review the Sr isotopic data of volcanic rocks from oceanic regions and the available experimental data on diffusion kinetics in minerals and melts similar to those existing in the mantle. Although diffusion data are scarce and afflicted with uncertainties, most of the diffusion coefficients for cations in mantle minerals at temperatures of 1000 to 1200/sup 0/C appear to be greater than 10/sup -13/ cm/sup 2/ s/sup -1/. Struntium diffusion in liquid basalt is more rapid, with diffusion coefficients of D = 10/sup -7/ to 10/sup -6/ cm/sup 2/ s/sup -1/ near 1300/sup 0/C. Simple model calculations show that, with these D values, a fluid-free mantle can maintain a state of disequilibrium on a centimeter scale for periods of 10/sup 8/ to 10/sup 9/ years. The state of disequilibrium found in many mantle-derived xenoliths is thus easily explained. A partially molten mantle, on the other hand, will tend to equilibrate locally in less than 10/sup 5/ to 10/sup 6/ years. The analytical data on natural rocks likewise indicate that the inhomogeneities are both old (> 1.5 b.y.) and regional in character and that the consistent isotopic differences between ocean island and ocean floor volcanics cannot be explained by small-scall hetorogeneity of the source rock.

  16. Approximate Dynamic Programming: Combining Regional and Local State Following Approximations.

    Science.gov (United States)

    Deptula, Patryk; Rosenfeld, Joel A; Kamalapurkar, Rushikesh; Dixon, Warren E

    2018-06-01

    An infinite-horizon optimal regulation problem for a control-affine deterministic system is solved online using a local state following (StaF) kernel and a regional model-based reinforcement learning (R-MBRL) method to approximate the value function. Unlike traditional methods such as R-MBRL that aim to approximate the value function over a large compact set, the StaF kernel approach aims to approximate the value function in a local neighborhood of the state that travels within a compact set. In this paper, the value function is approximated using a state-dependent convex combination of the StaF-based and the R-MBRL-based approximations. As the state enters a neighborhood containing the origin, the value function transitions from being approximated by the StaF approach to the R-MBRL approach. Semiglobal uniformly ultimately bounded (SGUUB) convergence of the system states to the origin is established using a Lyapunov-based analysis. Simulation results are provided for two, three, six, and ten-state dynamical systems to demonstrate the scalability and performance of the developed method.

  17. AIRPORT NOISE CHARGES AND LOCAL COMMUNITIES: APPLICATION TO REGIONAL AIRPORTS

    Directory of Open Access Journals (Sweden)

    LUCA MANTECCHINI

    2016-11-01

    Full Text Available There have always been conflicts among airports and local communities due to the aeronautical noise generated by airport operations. In fact, this is a factor that - if not properly managed - could severely cut down the growth of air traffic in an airport with direct effects on the economic and territorial system. Beside this, in the last decade the critical issues related to the impact of aeronautical noise on airport operations have greatly reduced, thanks to technological improvements in aircraft design. Nevertheless, the reduction of noise emissions during a single aircraft operation does not make the issue of the airports’ location less important. This is the case of regional airports in EU, which have recently experimented a large traffic increase due to the development of low-cost traffic. It is now clear that the problem cannot be reduced to its mere technological aspect, but it ought to be dealt with the involvement of the various stakeholders in order to mitigate the emissions and adequately compensate the impacts to local communities. Typically, there are two possible countermeasures to mitigate the effects of aircraft noise: operational measures, based on the application of technological and organizational devices and market-based measures. The application of noise taxes, aiming at compensating the negative externalities generated by airport operations is becoming increasingly widespread in EU. In this paper, a methodology for the application of noise taxes based on the actual noise of aircraft operating into an airport is discussed and implemented in a test case.

  18. Philosophy of river problems: local to regional, static to mobile

    International Nuclear Information System (INIS)

    Jansky, L.

    1997-01-01

    According to the statistics, thirteen of the twenty-five major river basins in Europe are basins of transboundary rivers. The Danube river basin is largest transboundary river basin in Europe. Almost in each case the local and regional problems arise, like division of fishing rights (or rights on river beds), right to claim tolls on navigation, how to adjust boundaries if the channel moves, or rights to claim duty on crossing the river, or to build bridges, weirs, etc. All the above problems on a larger scale include also rights of non-contiguous lands (i.e. not fronting on the river) to use the river for navigation, for passage of migrating fish, to exploit river (e.g. bed sediments) without damage by one country or society to another below. Similarly, pollution and large-scale removal of water, are problems on regional or national levels. Disputes usually arise from the above, more or less exacerbated by their superimposition or other non-river problems, e.g. religion, politics, historical issues, recent aggression, relative prosperity, expanding economy vs. contrasting economy. May be cause or consequence of many of these. And somewhere here is likely the case of Gabcikovo on Danube between Slovakia and Hungary, as well. (author)

  19. Geomagnetic secular variation in India-regional and local features

    International Nuclear Information System (INIS)

    Srivastava, B.J.; Abbas, H.

    1977-01-01

    A study of the secular variation in the geomagnetic elements H, Z, F and D at Colaba (Bombay)-Alibag for the period 1848-1973, has been made. Fifth degree polynomials are fitted to the data of annual mean values of H, Z and F, and third degree to D, and the residuals discussed. The trends are also examined at the six Indian observatories using the data for 1960-1974. The increasing trend of Z at Alibag is found to decrease from about 1937, while that of H and F from 1965 at 20-30 nT/year, it being of the same order at Sabhawala and Hyderabad but smaller at the equatorial stations, particularly for Z component. The westward annual change in D swings eastward again around 1965 at all the Indian stations. This reversal of the secular variation trend in India after 1965 emerges as an important regional feature connected with a southward migration of the dip equator in India from 1968. The secular change in D at Alibag (+0.4'/year) is somewhat anomalous in the sense that it is reduced as compared to Hyderabad and other stations (+1.6'/year), probably due to the local magnetic anomaly of the Deccan lavas, and calls for detailed investigations. (auth.)

  20. The role of local taxes on regional development in Jambi Province

    Directory of Open Access Journals (Sweden)

    Siti Hodijah

    2017-12-01

    Full Text Available Regional tax is a compulsory duty made by an individual or entity to a region without equal direct repayment that can be enforced under applicable legislation, which is used to finance the administration of local government and regional development. The role of local taxes is to assist the development of APBD (Local Government Budget activities. Local governments are also exploring new local taxes annually that can be used for regional expenditure. This research was conducted in Jambi Province. This research uses descriptive method that the data obtained then arranged in such a way and analyzed correctly based on theory relevant to the problem. From the research results obtained growth of Jambi provincial tax in 2011-2015 fluctuate and tend to increase. Local tax contribution on Jambi provincial expenditure has decreased from year to year. Keywords: Local Tax, Regional Expenditure, Regional Development

  1. Local Sustainability and Cooperation Actions in the Mediterranean Region

    Directory of Open Access Journals (Sweden)

    Tiberio Daddi

    2014-05-01

    Full Text Available The populations of the Middle East and Africa are increasing rapidly, contributing to rapid urban growth. This paper describes a two-year action research process involving diverse public, private, and community stakeholders. The actions aimed to develop and strengthen the capabilities of three Mediterranean cities (Marrakech, Morocco; Sin el Fil, Lebanon; and Bodrum, Turkey in managing and promoting local sustainable development. The needs and priorities of each Mediterranean partner were identified and pilot actions were elaborated to promote urban sustainability, the exploitation of local resources, and the enhancement of local tangible and intangible assets. The paper describes the outputs of pilot actions carried out in these cities, highlighting how these experiences contribute to the current debate on urban sustainability. Broad implications for policy and practice are discussed.

  2. Local politics, conflict and development in Peruvian mining regions

    OpenAIRE

    Arellano-Yanguas, Javier

    2011-01-01

    This thesis examines the effects of a collection of policies that determine the\\ud mandatory distribution of mining, gas and oil revenues between national and subnational\\ud governments, and the greater involvement of mining companies in local\\ud development. I have labelled this set of policies, which aims to reduce social\\ud conflict and promote local development, the New Extractive Industry Strategy\\ud (NEIS).\\ud \\ud Chapter 1 describes the implementation of these policies in Peru and high...

  3. LOCAL DEVELOPMENT IN NORTHEST REGION THROUGH ACTIVITIES IN ITC DOMAIN

    Directory of Open Access Journals (Sweden)

    Daniela\tENACHESCU

    2015-06-01

    Full Text Available Economic areas with high technology are key drivers in sustainable regional development, including unemployment and consequently decreasing population migration in the region. Northeast Region is the largest development region of Romania in terms of number of inhabitants and the owned area. On 01/01/2014, according to balance employment, labor resources of the region were numbered 2,428,700, which represent 49.6% of employed population. The registered unemployment rate at 31 August 2014 was 6.5%, with 82 thousand unemployed registered. In terms of participation in the main economic activities, civilian employment in agriculture, forestry and fishing is predominant (40.1% while in service, civilian employment is 37.1%, while industry and construction is 22.8%. The paper aims to analyze the situation that the potential employment and development opportunities for the Northeast region through activities in the field of ITC domain. Unfortunately, this area was the worst in most indicators, the use of computers and the internet to the turnover of companies and investments in the IT & C and unfortunately in terms of employment population that is under 50%

  4. Impact of regional special purpose local option sales tax (SPLOST) initiatives on county infrastructure.

    Science.gov (United States)

    2011-10-01

    In response to fiscal constraints on transportation funding and the need to address transportation problems and create regional solutions, Georgia is proposing a 1% regional Special-Purpose Local-Option Sales Tax (SPLOST). To accommodate this initiat...

  5. Reaching Regional and Local Learners via a Great Lakes MOOC

    Science.gov (United States)

    Mooney, M. E.; Ackerman, S. A.

    2015-12-01

    The Cooperative Institute of Meteorological Satellite Studies (CIMSS) took a regional approach to climate change education in a 4-week MOOC (Massive Open On-line Course) on the Changing Weather and Climate in the Great Lakes Region launched in February 2015. Featuring a different season each week, this Great Lakes MOOC includes lectures about seasonal weather conditions, observed changes, and societal impacts of regional climate change, as well as actions with co-benefits to slow future climate change. To better connect with learners, CIMSS facilitated 21 discussion groups at public libraries around Wisconsin each week. Participants discussed climate change impacts in their communities as well as strategies to mitigate climate change. Not surprisingly, initial survey results show library participants were more committed, engaged, climate literate, and community minded. This session will share lessons learned and survey results from the Great Lakes MOOC which remains open and accessible on Coursera through February 2016 at https://www.coursera.org/course/greatlakesclimate.

  6. Generic Regional Development Strategies from Local Stakeholders' Scenarios - an Alpine Village Experience

    Directory of Open Access Journals (Sweden)

    Wolfgang Loibl

    2010-09-01

    Full Text Available The article discusses the participatory elaboration of strategies for sustainable regional development in an Alpine tourist region in Austria to cope with global change effects evolving locally, considering climate change, economic change as well as (local societal change. Local stakeholders in an Alpine village in the Montafon region contributed in workshops to achieve the final results: participant teams conducted system analyses of the regional system to explore key elements of the region. Narrative scenarios described possible positive and negative development trends and indicated the critical issues controlling future development; 3D-images of landscape transition simulations show the consequences of certain development directions. Alternative development directions supported the local stakeholders to elaborate regional development strategies. In the end, the scientist team derived generic strategies for Alpine regions based on the locally developed strategy bundle. The article presents the intention, progress and outcome of the participatory approach and elaborates the potential to derive generic strategies from local ones and discusses the possibly occurring conflicts regarding cross-scale transfers of these local strategies. Overall, tourism was seen as a key element for future regional development, which can on the one hand derogate Alpine regions and is on the other hand threatened by climate change and diminution of landscape attractiveness. The suggested development strategies will help to cope with global change issues mitigating the negative consequences on the local society and environment.

  7. Regional Planning, Local Visions : Participatory Futuring in West Africa

    OpenAIRE

    Peter Easton

    2000-01-01

    The note examines regional planning, and future participatory methods for economic development in West Africa, based on the work carried out by the Club du Sahel - a branch of the Organization for Economic Cooperation and Development (OECD) - responsible for coordinating northern donor agencies, in support of food security, and natural resource management in the desert-edge portions of Wes...

  8. Species of conservation concern and environmental stressors: Local, regional and global effects [Chapter 6] (Executive Summary)

    Science.gov (United States)

    Steven M. Ostoja; Matthew L. Brooks; Jeanne C. Chambers; Burton K. Pendleton

    2013-01-01

    Southern Nevada’s unique landscapes and landforms provide habitat for a diversity of plant and wildlife species of conservation concern including many locally and regionally endemic species. The high population density and urbanization of the Las Vegas metropolitan area is the source of many local and regional stressors that affect these species and their habitats:...

  9. Universities Potential Role in Local and Regional Development

    DEFF Research Database (Denmark)

    Moesby, Egon; Rolim, Cassio

    2013-01-01

    Purpose: The paper will describe experiences from Aalborg University in Denmark on ways to support cooperation between the University and regional civic/business. Design/Methodology: Regional development is exceedingly focused in the world; and as growth is dependent on specialised knowledge...... and highly skilled and competent staff, it could be anticipated that universities should play a key role in facilitating such growth and development. At Aalborg University, such cooperation is taking place, and this paper sums up the practices and experiences gained therefrom. Findings: Universities have...... been and maybe still are seen as bodies focusing on know-how; however, they are now focusing on technology transfer, knowledge transfer and knowledge exchange, and maybe also on co-designing. From such beginnings co-operation can, and in many cases has, further developed into formal partnerships...

  10. SPATIAL DISTRIBUTIONS OF ABSORPTION, LOCAL SUPPRESSION, AND EMISSIVITY REDUCTION OF SOLAR ACOUSTIC WAVES IN MAGNETIC REGIONS

    International Nuclear Information System (INIS)

    Chou, D.-Y.; Yang, M.-H.; Zhao Hui; Liang Zhichao; Sun, M.-T.

    2009-01-01

    Observed acoustic power in magnetic regions is lower than the quiet Sun because of absorption, emissivity reduction, and local suppression of solar acoustic waves in magnetic regions. In the previous studies, we have developed a method to measure the coefficients of absorption, emissivity reduction, and local suppression of sunspots. In this study, we go one step further to measure the spatial distributions of three coefficients in two active regions, NOAA 9055 and 9057. The maps of absorption, emissivity reduction, and local suppression coefficients correlate with the magnetic map, including plage regions, except the emissivity reduction coefficient of NOAA 9055 where the emissivity reduction coefficient is too weak and lost among the noise.

  11. Capacity-building activities for local leadership in Egypt from the local to the national and regional levels.

    Science.gov (United States)

    El Sioufi, M

    1996-03-01

    In order to make the Sustainable Ismailia Project institutionally sustainable, the National Project Manager identified the need to build the capacity of local leadership. The Training Section, in UNCHS, proposed a capacity-building program designed to respond to this demand focusing on the skill-training and attitude formation needed for effective local leadership. The proposed program is adapted from the "Training for Elected Leadership" series widely tested and used in many regions. It combines direct training for local officials from villages in Ismailia, and indirect training for trainers from the Ministry of Local Administration (MLA). After the course, the MLA trainers would design a training program which they will implement nationally. The Minister for Local Administration decided to finance the translation and production of the manuals, while the Governor of Ismailia offered to cover the trainees' expenses. The UNCHS Training and Capacity-Building Section would provide technical guidance and coordinate and implement the program. Once the Arabic version of the training materials would be available, UNCHS would use it regionally to reach out to other Arab States. This example illustrates how concerned stakeholders cooperate to address capacity-building needs. The UNCHS Training Section assumes the role of facilitator and acts as a catalyst for the formulation of such activities. The feeling of ownership of the locally produced/adapted training materials enhances the propensity of their effective and extensive use. This approach has succeeded across regions, cultures, and languages with out-reaching multiplier effects. full text

  12. Local and regional air quality over 1997 based on decrees

    International Nuclear Information System (INIS)

    Vissenberg, H.A.; Warmenhoven, R.C.G.

    1999-01-01

    Eleven of the 12 Dutch provinces and 52 of the 79 municipalities (over 40.000 inhabitants) reported on their air quality for 19997. The National Institute of Public Health and the Environment (RIVM) and the Directorate-General for Environmental Protection of the Ministry of VROM then combined these reports into an annual national report for 1997. The largest in several years, still 35 percent of the municipalities failed to meet their reported obligations. Most of the reports on air quality are incomplete on the contribution of large point sources and traffic to local air quality. For 1997 one province reported an exceedence of the limit value of nitrogen dioxide. In four provinces the target value of nitrogen dioxide was exceeded. The province of Zuid-Holland has to report next year on its air quality over 1998 because of exceeding of the limit value and the provinces Friesland and Utrecht have to report because they did not report (completely) over 1997. The 52 municipalities reported in total 60 exceedences of the (provisional) limit value over 1997: 20 roads with an exceedence of the nitrogen dioxide (provisional) limit value, 2 roads with an exceedence of the carbon monoxide limit value and 38 roads with an exceedance of the benzene limit value. Nine municipalities have to report on their air quality over 1998; Amsterdam, Arnhem, Breda, Den Haag, Leiden, Nijmegen, Sittard, Utrecht and Zwolle. Also the 27 municipalities which did not report over 1997 have to report over 1998; Alphen a/d Rijn, Dordrecht, Ede, Eindhoven, Enschede, Gouda, Groningen, Heerhugowaard, Heerlen, Helmond, 's Hertogenbosch, Heusden, Katwijk, Leeuwarden, Maarssen, Maastricht, Oosterhout, Oss, Purmerend, Ridderkerk, Roosendaal, Veldhoven, Smallingerland, Tilburg, Velsen, Vlaardingen and Zwijndrecht. Seven provinces and eight municipalities also reported on their policy to either maintain their air quality or improve it. Exceedance of limit values means that on a local scale air quality

  13. Regional Technolgy Policy and Factors Shaping Local Innovation Networks in Small German Cities

    OpenAIRE

    Gebauer, Andrea; Nam, Chang Woon; Parsche, Rüdiger

    2003-01-01

    Local innovation networks have been considered to be particularly important to innovation and technological change and to the growth prospects of regions and cities in Germany. Accordingly, innovation is a process that results from various (economic and social) interactions of different institutions located in a given region. Consequently, when analysing the local (or regional) innovation system, one should not only investigate the (horizontal and vertical) relations among firms but also the ...

  14. Statistical Downscaling Of Local Climate In The Alpine Region

    Science.gov (United States)

    Kaspar, Severin; Philipp, Andreas; Jacobeit, Jucundus

    2016-04-01

    The impact of climate change on the alpine region was disproportional strong in the past decades compared to the surrounding areas, which becomes manifest in a higher increase in surface air temperature. Beside the thermal changes also implications for the hydrological cycle may be expected, acting as a very important factor not only for the ecosystem but also for mankind, in the form of water security or considering economical aspects like winter tourism etc. Therefore, in climate impact studies, it is necessary to focus on variables with high influence on the hydrological cycle, for example temperature, precipitation, wind, humidity and radiation. The aim of this study is to build statistical downscaling models which are able to reproduce temperature and precipitation at the mountainous alpine weather stations Zugspitze and Sonnblick and to further project these models into the future to identify possible changes in the behavior of these climate variables and with that in the hydrological cycle. Beside facing a in general very complex terrain in this high elevated regions, we have the advantage of a more direct atmospheric influence on the meteorology of the exposed weather stations from the large scale circulation. Two nonlinear statistical methods are developed to model the station-data series on a daily basis: On the one hand a conditional classification approach was used and on the other hand a model based on artificial neural networks (ANNs) was built. The latter is in focus of this presentation. One of the important steps of developing a new model approach is to find a reliable predictor setup with e.g. informative predictor variables or adequate location and size of the spatial domain. The question is: Can we include synoptic background knowledge to identify an optimal domain for an ANN approach? The yet developed ANN setups and configurations show promising results in downscaling both, temperature (up to 80 % of explained variance) and precipitation (up

  15. Reorganization of water and waste water management in Romania : from local to regional water governance

    NARCIS (Netherlands)

    Vinke-de Kruijf, Joanne; Dinica, Valentina; Augustijn, Denie C.M.

    2009-01-01

    Romania's drinking water and wastewater sector is currently going through a process of regionalization. This process involves a replacement of a local-focused governance structure by a regional-focused governance structure. The objective of this paper is to explore and explain this regionalization

  16. ABUNDANCES IN THE LOCAL REGION. I. G AND K GIANTS

    Energy Technology Data Exchange (ETDEWEB)

    Luck, R. Earle, E-mail: rel2@case.edu [Department of Astronomy, Case Western Reserve University 10900 Euclid Avenue, Cleveland, OH 44106-7215 (United States)

    2015-09-15

    Parameters and abundances for 1133 stars of spectral types F, G, and K of luminosity class III have been derived. In terms of stellar parameters, the primary point of interest is the disagreement between gravities derived with masses determined from isochrones, and gravities determined from an ionization balance. This is not a new result per se, but the size of this sample emphasizes the severity of the problem. A variety of arguments led to the selection of the ionization-balance gravity as the working value. The derived abundances indicate that the giants in the solar region have Sun-like total abundances and abundance ratios. Stellar evolution indicators have also been investigated with the Li abundances and the [C/Fe] and C/O ratios, indicating that standard processing has been operating in these stars. The more salient result for stellar evolution is that the [C/Fe] data across the red-giant clump indicates the presence of mass-dependent mixing in accord with standard stellar evolution predictions.

  17. Deep local and regional hyperthermia with annular phased array

    International Nuclear Information System (INIS)

    Uehara, S.; Omagari, J.; Hata, K.

    1989-01-01

    33 refractory tumors mainly located in the pelvic cavity after definitive treatment were treated by loco-regional hyperthermia alone (n = 11) or by heat in combination with radiotherapy (n = 22) by annular phased array (APA) manufactured by BSD Corp. Tumors were heated up to more than 42 0 C in 78% of 347 total heat sessions with induction time 22 ± 1 (S.D.) minutes during which those of intra-pelvic organs were elevated up to between 41 and 42 0 C. Tumor response was CR 18%, PR 50% by heat (11.2 ± 1.5 S.D. fractions) combined with radiotherapy (43.8 ± 12.5 S.D. Gy) and by heat alone (8.6 ± 1.3 S.D. fractions) CR 18%, PR 9%. In all heat sessions superficial pain 36%, skin burn (grade 1-2) 12% inside annular array and slight to moderate systemic heat stress 100% were the main adverse reactions we experienced. (orig.)

  18. Membrane localization and dynamics of geranylgeranylated Rab5 hypervariable region.

    Science.gov (United States)

    Edler, Eileen; Schulze, Eric; Stein, Matthias

    2017-08-01

    The small GTPase Rab5 is a key regulator of endosomal trafficking processes and a marker for the early endosome. The C-terminal hypervariable region (HVR) of Rab5 is post-translationally modified at residues Cys 212 and Cys 213 to accommodate two geranylgeranyl anchors (C20 carbon chain length) in order to associate Rab5 with the membrane. The structural role of the HVR regarding protein-early endosome membrane recruitment is not resolved due to its high degree of flexibility and lack of crystallographic information. Here, full-atomistic and coarse-grained molecular dynamics simulations of the truncated Rab5 HVR 206-215 in three model membranes of increasing complexity (pure phospholipid bilayer, ternary membrane with cholesterol, six-component early endosome) were performed. Specific electrostatic interactions between the HVR 206-215 Arg 209 residue and the phosphate group of the inositol ring of PI(3)P were detected. This shows that PI(3)P acts as a first contact site of protein recruitment to the early endosome. The free energy change of HVR 206-215 extraction from the bilayer was largest for the physiological negatively charged membrane. 5μs coarse-grained simulations revealed an active recruitment of PI(3)P to the HVR 206-215 supporting the formation of Rab5- and PI(3)P enriched signaling platforms. Copyright © 2017 Elsevier B.V. All rights reserved.

  19. Preliminary results of local earthquake tomography around Bali, Lombok, and Sumbawa regions

    Energy Technology Data Exchange (ETDEWEB)

    Nugraha, Andri Dian, E-mail: nugraha@gf.itb.ac.id; Puspito, Nanang T; Yudistira, Tedi [Global Geophysical Reserach Group, Faculty of Mining and Petroleum Engineering, Institute of Technology Bandung, JlGanesa 10, Bandung, 40132 (Indonesia); Kusnandar, Ridwan; Sakti, Artadi Pria [Meteorological, Climatological, and Geophysical Agency (MCGA) of Indonesian, Jakarta (Indonesia)

    2015-04-24

    Bali, Sumbawa, and Lombok regions are located in active tectonic influence by Indo-Australia plate subducts beneath Sunda plate in southern part and local back-arc thrust in northern part the region. Some active volcanoes also lie from eastern part of Java, Bali, Lombok and Sumbawa regions. Previous studies have conducted subsurface seismic velocity imaging using regional and global earthquake data around the region. In this study, we used P-arrival time from local earthquake networks compiled by MCGA, Indonesia within time periods of 2009 up to 2013 to determine seismic velocity structure and simultaneously hypocenter adjustment by applying seismic tomography inversion method. For the tomographic inversion procedure, we started from 1-D initial velocity structure. We evaluated the resolution of tomography inversion results through checkerboard test and calculating derivative weigh sum. The preliminary results of tomography inversion show fairly clearly high seismic velocity subducting Indo-Australian and low velocity anomaly around volcano regions. The relocated hypocenters seem to cluster around the local fault system such as back-arc thrust fault in northern part of the region and around local fault in Sumbawa regions. Our local earthquake tomography results demonstrated consistent with previous studies and improved the resolution. For future works, we will determine S-wave velocity structure using S-wave arrival time to enhance our understanding of geological processes and for much better interpretation.

  20. Improved local and regional control with radiotherapy for Merkel cell carcinoma of the head and neck.

    Science.gov (United States)

    Strom, Tobin; Naghavi, Arash O; Messina, Jane L; Kim, Sungjune; Torres-Roca, Javier F; Russell, Jeffery; Sondak, Vernon K; Padhya, Tapan A; Trotti, Andy M; Caudell, Jimmy J; Harrison, Louis B

    2017-01-01

    We hypothesized that radiotherapy (RT) would improve both local and regional control with Merkel cell carcinoma of the head and neck. A single-institution institutional review board-approved study was performed including 113 patients with nonmetastatic Merkel cell carcinoma of the head and neck. Postoperative RT was delivered to the primary tumor bed (71.7% cases) ± draining lymphatics (33.3% RT cases). Postoperative local RT was associated with improved local control (3-year actuarial local control 89.4% vs 68.1%; p = .005; Cox hazard ratio [HR] 0.18; 95% confidence interval [CI] = 0.06-0.55; p = .002). Similarly, regional RT was associated with improved regional control (3-year actuarial regional control 95.0% vs 66.7%; p = .008; Cox HR = 0.09; 95% CI = 0.01-0.69; p = .02). Regional RT played an important role for both clinical node-negative patients (3-year regional control 100% vs 44.7%; p = .03) and clinical/pathological node-positive patients (3-year regional control 90.9% vs 55.6%; p = .047). Local RT was beneficial for all patients with Merkel cell carcinoma of the head and neck, whereas regional RT was beneficial for clinical node-negative and clinical/pathological node-positive patients. © 2016 Wiley Periodicals, Inc. Head Neck 39: 48-55, 2017. © 2016 Wiley Periodicals, Inc.

  1. Local Road Safety Peer Exchange - Region 9 : An RSPCB Peer Exchange

    Science.gov (United States)

    2013-09-01

    This report provides a summary of the proceedings of the Region 9 Local Road Safety Peer : Exchange held in Sacramento, California on September 17 and 18, 2013. The Federal Highway : Administration (FHWA) Office of Safety (HSA) sponsored the peer exc...

  2. Articaine: a review of its use for local and regional anesthesia

    OpenAIRE

    Snoeck, Marc

    2012-01-01

    Marc SnoeckDepartment of Anaesthesia, Canisius-Wilhelmina Hospital, Nijmegen, The NetherlandsAbstract: Articaine is an intermediate-potency, short-acting amide local anesthetic with a fast metabolism due to an ester group in its structure. It is effective with local infiltration or peripheral nerve block in dentistry, when administered as a spinal, epidural, ocular, or regional nerve block, or when injected intravenously for regional anesthesia. In comparative trials, its clinical effects wer...

  3. Strong influence of regional species pools on continent-wide structuring of local communities

    OpenAIRE

    Lessard, Jean-Philippe; Borregaard, Michael K.; Fordyce, James A.; Rahbek, Carsten; Weiser, Michael D.; Dunn, Robert R.; Sanders, Nathan J.

    2011-01-01

    There is a long tradition in ecology of evaluating the relative contribution of the regional species pool and local interactions on the structure of local communities. Similarly, a growing number of studies assess the phylogenetic structure of communities, relative to that in the regional species pool, to examine the interplay between broad-scale evolutionary and fine-scale ecological processes. Finally, a renewed interest in the influence of species source pools on communities has shown that...

  4. Local self-government potential in sustainable development of region providing

    Directory of Open Access Journals (Sweden)

    O. Y. Bobrovska

    2016-06-01

    Full Text Available Ongoing decentralization of power in Ukraine enhances abilities of each region to independently choose their development path and use their own resources. It requires reviewing and updating of mechanisms and instruments of local government and public administration projected to increase the sustainability of development. This necessitates further research of issues of this extremely complex phenomenon. The problem of sustainable development of the regions and their internal capacities over the past decades has attracted the attention of many Ukrainian scientists. They considered the question of the essence and characteristics of this phenomenon, categorical apparatus, and formed approaches to the assessment of the state etc. Existing scientific researchers provided an opportunity for better understanding and deepening of the issues of processes of development formation, becoming the basis for further research. The purpose of the article is the definition of the potential of local governments in the sustainable development of the region, finding approaches for improving management and rational use of resources to enhance the regional development. Development of regions is the scope of display of results and public nature of local self-government. However, the results which are achieved by regional development and its level of sustainability do not meet the needs of society. The results of ongoing reforms, their economic, environmental and social significance do not correspond to spent resources and efforts of society. Strategies of regions for the transition to sustainable development are not systematic. To search for answers and ways to address the issues of the article attempts to identify common root causes in the organization of local government, the underlying increase its impact in the direction of creating conditions and ensure the flow of sustainable regional development through research and their potential influential factors. It is

  5. Evidence for local inflammation in complex regional pain syndrome type 1

    Directory of Open Access Journals (Sweden)

    Frank J. P. M. Huygen

    2002-01-01

    Full Text Available Background: The pathophysiology of complex regional pain syndrome type 1 (CRPS 1 is still a matter of debate. Peripheral afferent, efferent and central mechanisms are supposed. Based on clinical signs and symptoms (e.g. oedema, local temperature changes and chronic pain local inflammation is suspected.

  6. Local Road Safety Peer Exchange - Region 4 : An RSPCB Peer Exchange

    Science.gov (United States)

    2013-03-01

    This report provides a summary of the proceedings of the Local Road Safety Peer Exchange held in Atlanta, Georgia on March 6th and 7th, 2013. The Federal Highway Administration (FHWA) sponsored the Peer Exchange in coordination with Region 4 Local Te...

  7. Local Road Safety Peer Exchange - Region 7 : An RSPCB Peer Exchange

    Science.gov (United States)

    2012-05-01

    This report provides a summary of the proceedings of the Local Road Safety Peer Exchange held in Denver, Colorado from May 31 to June 1, 2012. The Federal Highway Administration (FHWA) sponsored the Peer Exchange in coordination with Region 7 Local a...

  8. Local Road Safety Peer Exchange - Regions 3 & 5 : An RSPCB Peer Exchange

    Science.gov (United States)

    2013-06-01

    This report provides a summary of the proceedings of the Local Road Safety Peer Exchange held in Columbus, Ohio on June 12 and 13, 2013. The Federal Highway Administration (FHWA) sponsored the Peer Exchange in coordination with the Region 3 & 5 Local...

  9. Geological disposal of radioactive wastes: national commitment, local and regional involvement

    International Nuclear Information System (INIS)

    2013-07-01

    Long-term radioactive waste management, including geological disposal, involves the construction of a limited number of facilities and it is therefore a national challenge with a strong local/regional dimension. Public information, consultation and/or participation in environmental or technological decision-making are today's best practice and must take place at the different geographical and political scales. Large-scale technology projects are much more likely to be accepted when stakeholders have been involved in making them possible and have developed a sense of interest in or responsibility for them. In this way, national commitment, and local and regional involvement are two essential dimensions of the complex task of securing continued societal agreement for the deep geological disposal of radioactive wastes. Long-term radioactive waste management, including geological disposal, is a national challenge with a strong local/regional dimension. The national policy frameworks increasingly support participatory, flexible and accountable processes. Radioactive waste management institutions are evolving away from a technocratic stance, demonstrating constructive interest in learning and adapting to societal requirements. Empowerment of the local and regional actors has been growing steadily in the last decade. Regional and local players tend to take an active role concerning the siting and implementation of geological repositories. National commitment and local/regional involvement go hand-in-hand in supporting sustainable decisions for the geological disposal of radioactive waste

  10. Including capabilities of local actors in regional economic development: Empirical results of local seaweed industries in Sulawesi

    Directory of Open Access Journals (Sweden)

    Mark T.J. Vredegoor

    2013-11-01

    Full Text Available Stimson, et al. (2009 developed one of the most relevant and well known model for Regional Economic Development. This model covers the most important factors related to economic development question. However, this model excludes the social components of development. Local community should be included in terms of the development of a region. This paper introduced to the Stimson model “Skills” and “Knowledge” at the individual level for local actors indicating the capabilities at the individual level and introduced “Human Coordination” for the capabilities at the collective level. In our empirical research we looked at the Indonesian seaweed market with a specific focus on the region of Baubau. This region was chosen because there are hardly any economic developments. Furthermore this study focuses on the poorer community who are trying to improve their situation by the cultivation of Seaweed. Eighteen local informants was interviewed besides additional interviews of informants from educational and governmental institutions in the cities of Jakarta, Bandung and Yogyakarta. The informants selected had a direct or indirect relationship with the region of Baubau. With the support of the empirical data from this region we can confirm that it is worthwhile to include the local community in the model for regional economic development.  The newly added variables: at the individual level; Skills and Knowledge and at the level of the collective: Human Coordination was supported by the empirical material. It is an indication that including the new variables can give regional economic an extra dimension.  In this way we think that it becomes more explicit that “endogenous” means that the people, or variables closely related to them, should be more explicitly included in models trying to capture Regional Economic Development or rephrased as Local Economic Development Keywords:Regional and endogenous development; Fisheries and seaweed

  11. Differential subcellular localization of insulin receptor substrates depends on C-terminal regions and importin β

    International Nuclear Information System (INIS)

    Kabuta, Tomohiro; Take, Kazumi; Kabuta, Chihana; Hakuno, Fumihiko; Takahashi, Shin-Ichiro

    2008-01-01

    Insulin receptor substrates (IRSs) play essential roles in signal transduction of insulin and insulin-like growth factors. Previously, we showed that IRS-3 is localized to the nucleus as well as the cytosol, while IRS-1 and 2 are mainly localized to the cytoplasm. In the present study, we found that importin β directly interacts with IRS-3 and is able to mediate nuclear transport of IRS-3. Importin β interacted with the pleckstrin homology domain, the phosphotyrosine binding domain and the C-terminal region of IRS-3; indeed all of these fragments exhibited predominant nuclear localization. By contrast, almost no interaction of importin β with IRS-1 and -2 was observed, and their C-terminal regions displayed discrete spotty images in the cytosol. In addition, using chimeric proteins between IRS-1 and IRS-3, we revealed that the C-terminal regions are the main determinants of the differing subcellular localizations of IRS-1 and IRS-3.

  12. Local Culture as a Resource in Regional Development in the Southwest-Finland Archipelago

    Directory of Open Access Journals (Sweden)

    Katriina Siivonen

    2011-03-01

    Full Text Available In cultural and regional politics in the European Union, and in practice for instance in the Southwest-Finland Archipelago, local culture and cultural heritage are considered resources. Global boundlessness, heterogeneity and change are basic qualities of culture. However, in regional development, culture is seen and used as a number of different local cultures with their own essential cultural heritage. The culture of local everyday life is opposite to, and in tension with, the construct of cultures used in regional development. Accordingly, culture should primarily be safeguarded as a heterogenic, dynamic and interactive process of everyday life. This process is the most important resource of local culture. In addition, culture should be safeguarded as value-based cultural constructions, such as brands or common identities of certain cultures, with for instance cultural heritage as a part of it. In the latter case, a common, transparent definition of these brands, identities and cultural heritages with their different values, is needed.

  13. Education and Training Needs in the Field of Local Development in the Lower Danube Macro Region

    Directory of Open Access Journals (Sweden)

    Laurenţiu Tăchiciu

    2010-11-01

    Full Text Available The present paper is the result of an effort made by the authors to explore the needs of education and training in the field of local development, according to the situation in Romanian and Bulgarian Danube bordering regions, aiming at designing joint projects to address such needs between the universities to which authors are affiliated. Local development is here understood as a deliberately induced process of improving the welfare of local communities, which should be democratic, inclusive and sustainable, in particular with regard to creating competitive local economies, stimulating economic growth and ensuring better living conditions for the inhabitants. Local development is an important part of a governance process which involves complex interactions at various territorially defined levels: local, regional, national, cross-national, international. In the case of the regions considered in the present paper a historical opportunity is provided for them by the so called European Union Strategy for the Danube Region. In order to fully exploit this opportunity, the capacity to address local development issues should be strengthened in both countries, especially by well designed education and training programmes. This is why local development was considered a priority topic for the cooperation between the two universities. In the same framework, taking into consideration the challenges which are specific to the Lower Danube Region, other topics of interest were considered: logistics, tourism, consumer affairs or rural development. The authors of the present paper had to avoid overlapping with the work of the other teams. In particular, there are many common points between local development and rural development, because in both countries the regions on the border of Danube are predominately rural and significantly dependent on agriculture. Therefore, here, the needs for education and training are defined in strict correlation with the required

  14. New computer simulation technology of WSPEEDI for local and regional environmental assessment during nuclear emergency

    International Nuclear Information System (INIS)

    Chino, Masamichi; Furuno, Akiko; Terada, Hiroaki; Kitabata, Hideyuki

    2002-01-01

    The increase of nuclear power plants in the Asian region necessitates the capability to predict long-range atmospheric dispersions of radionuclides and radiological impacts due to a nuclear accident. For this purpose, we have developed a computer-based emergency response system WSPEEDI. This paper aims to expanding the capability of WSPEEDI so that it can be applied to simultaneous multi-scale predictions of local and regional scales in the Asian region

  15. Strong influence of regional species pools on continent-wide structuring of local communities.

    Science.gov (United States)

    Lessard, Jean-Philippe; Borregaard, Michael K; Fordyce, James A; Rahbek, Carsten; Weiser, Michael D; Dunn, Robert R; Sanders, Nathan J

    2012-01-22

    There is a long tradition in ecology of evaluating the relative contribution of the regional species pool and local interactions on the structure of local communities. Similarly, a growing number of studies assess the phylogenetic structure of communities, relative to that in the regional species pool, to examine the interplay between broad-scale evolutionary and fine-scale ecological processes. Finally, a renewed interest in the influence of species source pools on communities has shown that the definition of the source pool influences interpretations of patterns of community structure. We use a continent-wide dataset of local ant communities and implement ecologically explicit source pool definitions to examine the relative importance of regional species pools and local interactions for shaping community structure. Then we assess which factors underlie systematic variation in the structure of communities along climatic gradients. We find that the average phylogenetic relatedness of species in ant communities decreases from tropical to temperate regions, but the strength of this relationship depends on the level of ecological realism in the definition of source pools. We conclude that the evolution of climatic niches influences the phylogenetic structure of regional source pools and that the influence of regional source pools on local community structure is strong.

  16. Local-regional control in breast cancer patients with a possible genetic predisposition

    International Nuclear Information System (INIS)

    Freedman, Laura M.; Buchholz, Thomas A.; Thames, Howard D.; Strom, Eric A.; McNeese, Marsha D.; Hortobagyi, Gabriel N.; Singletary, S. Eva; Heaton, Keith M.; Hunt, Kelly K.

    2000-01-01

    Purpose: Local control rates for breast cancer in genetically predisposed women are poorly defined. Because such a small percentage of breast cancer patients have proven germline mutations, surrogates, such as a family history for breast cancer, have been used to examine this issue. The purpose of this study was to evaluate local-regional control following breast conservation therapy (BCT) in patients with bilateral breast cancer and a breast cancer family history. Methods and Materials: We retrospectively reviewed records of all 58 patients with bilateral breast cancer and a breast cancer family history treated in our institution between 1959 and 1998. The primary surgical treatment was a breast-conserving procedure in 55 of the 116 breast cancer cases and a mastectomy in 61. The median follow-up was 68 months for the BCT patients and 57 months for the mastectomy-treated patients. Results: Eight local-regional recurrences occurred in the 55 cases treated with BCT, resulting in 5- and 10-year actuarial local-regional control rates of 86% and 76%, respectively. In the nine cases that did not receive radiation as a component of their BCT, four developed local-regional recurrences (5- and 10-year local-regional control rates of BCT without radiation: 49% and 49%). The 5- and 10-year actuarial local-regional control rates for the 46 cases treated with BCT and radiation were 94% and 83%, respectively. In these cases, there were two late local recurrences, developing at 8 years and 9 years, respectively. A log rank comparison of radiation versus no radiation actuarial data was significant at p = 0.009. In the cases treated with BCT, a multivariate analysis of radiation use, patient age, degree of family history, margin status, and stage revealed that only the use of radiation was associated with improved local control (Cox regression analysis p = 0.021). The 10-year actuarial rates of local-regional control following mastectomy with and without radiation were 91% and 89

  17. Community-led local development approach principles implementation when forming a regional local development projects support system in Ukraine

    Directory of Open Access Journals (Sweden)

    Y. G. Udod

    2017-03-01

    Full Text Available The article contains a brief description of the Community-led local development approach (local development under the leadership of the community, CLLD and the main purpose of its use in the European Union. The study indicated periods of the major initiatives to support local development in EU. Moreover the article posted CLLD approach principles’ evolution and the basic principles of the LEADER method and its application in CLLD, which can be applied in Ukraine. Subject to the provisions of the European Economic and Social Committee (EESC for further CLLD-approach distribution the five trends were identified that must be considered when forming a Regional local development projects support system in Ukraine: Multi-fund financing; Unification; Networking and collaboration; Extending the approach; Simplifying the process. The characteristic of the present phase of CLLD-approach, in particular, of the European Network for Rural Development (ENRD, which attaches great importance to the dissemination of the most effective CLLD practices and establish partnerships between communities and territories where the approach is implemented. The study found out the relationship between Community-led local development and Community-driven development (CDD supported by the World Bank.

  18. Local and Regional Partnerships in Natural Resource Management: The Challenge of Bridging Institutional Levels

    Science.gov (United States)

    Prager, Katrin

    2010-11-01

    Although collaboration and multi-stakeholder partnerships have become a common feature in natural resource management throughout the world, various problems are associated with attempts to up-scale community-based natural resource management from the local to the regional level. To analyze the reasons behind these problems, this article reports on two examples of collaboratives in Australia: local Landcare groups, and regional natural resource management (NRM) bodies. Recent government-induced changes have shifted the focus from local Landcare group action to strategic planning and implementation by regional NRM bodies. Two typologies of collaboratives are applied to analyze the characteristics of both these groups. The study uses data from 52 qualitative interviews with key informants at the local and regional level in Victoria and Tasmania, participant observation, as well as literature and document analysis. The article illustrates how the groups’ distinct characteristics can cause conflicts when the different types of collaboratives operate in parallel. In addition, the article reports how stakeholders perceive the level of community participation in decision-making processes. The key message is that the benefits of community participation and collaboration that arise at the local level can be lost when these approaches are up-scaled to the regional level unless there is an intermediary or ‘mediating structure’ to facilitate communication and create the link between different types of collaboratives.

  19. Patterns of local-regional failure after primary intensity modulated radiotherapy for nasopharyngeal carcinoma

    International Nuclear Information System (INIS)

    Kong, Fangfang; Ying, Hongmei; Du, Chengrun; Huang, Shuang; Zhou, Junjun; Chen, Junchao; Sun, Lining; Chen, Xiaohui; Hu, Chaosu

    2014-01-01

    To analyze patterns of local-regional failure after primary intensity modulated radiotherapy (IMRT) for nasopharyngeal carcinoma (NPC). A total of 370 non-metastatic NPC patients consecutively treated with IMRT (with or without chemotherapy) were analyzed. Radiotherapy was administered using a simultaneous integrated boost (SIB) technique at the total prescribed dose of 66-70.4Gy (2.0-2.2Gy per fraction). The location and extent of local-regional failures were transferred to the pretreatment planning computed tomography (CT) for dosimetric analysis. The dose of radiation received by V recur (volume of recurrence) was calculated and analyzed with dose-volume histogram (DVH). Failures were classified as: 'in field' if 95% of V recur was within the 95% isodose, 'marginal' if 20% to 95% of V recur was within the 95% isodose, or 'outside' if less than 20% of V recur was inside the 95% isodose. With a median follow up of 26 months, 25 local-regional failures were found in 18 patients. The 1- and 2-year actuarial local-regional control rates for all patients were 99.7% and 95.5% respectively. Among the 22 local–regional failures with available diagnostic images, 16 (64%) occurred within the 95% isodose lines and were considered in-field failures; 3 (12%) were marginal and 3 (12%) were outside-field failures. Intensity-modulated radiotherapy provides excellent local-regional control for NPC. In-field failures are the main patterns for local-regional recurrence. Reducing the coverage of critical adjacent tissues in CTV purposefully for potential subclinical diseases was worth of study. Great attention in all IMRT steps is necessary to reduce potential causes of marginal failures. More studies about radioresistance are needed to reduce in-field failures

  20. Digital Sequences and a Time Reversal-Based Impact Region Imaging and Localization Method

    Science.gov (United States)

    Qiu, Lei; Yuan, Shenfang; Mei, Hanfei; Qian, Weifeng

    2013-01-01

    To reduce time and cost of damage inspection, on-line impact monitoring of aircraft composite structures is needed. A digital monitor based on an array of piezoelectric transducers (PZTs) is developed to record the impact region of impacts on-line. It is small in size, lightweight and has low power consumption, but there are two problems with the impact alarm region localization method of the digital monitor at the current stage. The first one is that the accuracy rate of the impact alarm region localization is low, especially on complex composite structures. The second problem is that the area of impact alarm region is large when a large scale structure is monitored and the number of PZTs is limited which increases the time and cost of damage inspections. To solve the two problems, an impact alarm region imaging and localization method based on digital sequences and time reversal is proposed. In this method, the frequency band of impact response signals is estimated based on the digital sequences first. Then, characteristic signals of impact response signals are constructed by sinusoidal modulation signals. Finally, the phase synthesis time reversal impact imaging method is adopted to obtain the impact region image. Depending on the image, an error ellipse is generated to give out the final impact alarm region. A validation experiment is implemented on a complex composite wing box of a real aircraft. The validation results show that the accuracy rate of impact alarm region localization is approximately 100%. The area of impact alarm region can be reduced and the number of PZTs needed to cover the same impact monitoring region is reduced by more than a half. PMID:24084123

  1. Modeling Local Monetary Flows in Poor Regions: A Research Setup to Simulate the Multiplier Effect in Local Economies

    Directory of Open Access Journals (Sweden)

    Henk van Arkel

    2007-10-01

    Full Text Available In poor regions, lack of local monetary circulation is one of the key elements causing underdevelopment. The more incoming money is passed from hand to hand, the more the local economy will be stimulated. However, in most poor areas money is spent outside the community before circulating locally, reducing the effectiveness of money inflow dramatically.Development programs would increase their effectiveness if knowledge was available on how spending money could lead to optimized and prolonged local circulation. To gain this knowledge a simulation tool will be created, which is able to analyze financial flows, to evaluate the potency of specific actions aimed on local development, and to monitor a development scheme during the execution phase.The basic model will be developed through a multi-agent approach, where each agent represents one (or more family/households belonging to one of several socio-economic groups. A Social Accounting Matrix (SAM of the local economy will be used as a basis to set up a spendings matrix for each agent, defining its spending priorities. Artificial Intelligence techniques will be used to give the agent the possibility to make decisions on how to satisfy these spending priorities. Also, social dynamics, the simulation of strategic planning behavior, learning, and exchange in limited networks will be addressed.The simulation application will consist of a common user interface allowing the user to “play” the simulation. This user interface layer will be “pluggable” with the underlying programming layer responsible for the calculations on the simulation, so that different plug-ins may be used for different simulation techniques.

  2. Articaine: a review of its use for local and regional anesthesia

    Directory of Open Access Journals (Sweden)

    Snoeck M

    2012-06-01

    Full Text Available Marc SnoeckDepartment of Anaesthesia, Canisius-Wilhelmina Hospital, Nijmegen, The NetherlandsAbstract: Articaine is an intermediate-potency, short-acting amide local anesthetic with a fast metabolism due to an ester group in its structure. It is effective with local infiltration or peripheral nerve block in dentistry, when administered as a spinal, epidural, ocular, or regional nerve block, or when injected intravenously for regional anesthesia. In comparative trials, its clinical effects were not generally significantly different from those of other short-acting local anesthetics like lidocaine, prilocaine, and chloroprocaine, and there is no conclusive evidence demonstrating above-average neurotoxicity. Articaine proved to be suitable and safe for procedures requiring a short duration of action in which a fast onset of anesthesia is desired, eg, dental procedures and ambulatory spinal anesthesia, in normal and in special populations.Keywords: articaine, regional anesthesia, pharmacodynamics, pharmacokinetics, therapeutic use, tolerability, neurotoxicity

  3. Inconsistent selection and definition of local and regional endpoints in breast cancer research.

    Science.gov (United States)

    Moossdorff, M; van Roozendaal, L M; Schipper, R-J; Strobbe, L J A; Voogd, A C; Tjan-Heijnen, V C G; Smidt, M L

    2014-12-01

    Results in breast cancer research are reported using study endpoints. Most are composite endpoints (such as locoregional recurrence), consisting of several components (for example local recurrence) that are in turn composed of specific events (such as skin recurrence). Inconsistent endpoint selection and definition might lead to unjustified conclusions when comparing study outcomes. This study aimed to determine which locoregional endpoints are used in breast cancer studies, and how these endpoints and their components are defined. PubMed was searched for breast cancer studies published in nine leading journals in 2011. Articles using endpoints with a local or regional component were included and definitions were compared. Twenty-three different endpoints with a local or regional component were extracted from 44 articles. Most frequently used were disease-free survival (25 articles), recurrence-free survival (7), local control (4), locoregional recurrence-free survival (3) and event-free survival (3). Different endpoints were used for similar outcomes. Of 23 endpoints, five were not defined and 18 were defined only partially. Of these, 16 contained a local and 13 a regional component. Included events were not specified in 33 of 57 (local) and 27 of 50 (regional) cases. Definitions of local components inconsistently included carcinoma in situ and skin and chest wall recurrences. Regional components inconsistently included specific nodal sites and skin and chest wall recurrences. Breast cancer studies use many different endpoints with a locoregional component. Definitions of endpoints and events are either not provided or vary between trials. To improve transparency, facilitate trial comparison and avoid unjustified conclusions, authors should report detailed definitions of all endpoints. © 2014 BJS Society Ltd. Published by John Wiley & Sons Ltd.

  4. A Local Region of Interest Imaging Method for Electrical Impedance Tomography with Internal Electrodes

    Directory of Open Access Journals (Sweden)

    Hyeuknam Kwon

    2013-01-01

    Full Text Available Electrical Impedance Tomography (EIT is a very attractive functional imaging method despite the low sensitivity and resolution. The use of internal electrodes with the conventional reconstruction algorithms was not enough to enhance image resolution and accuracy in the region of interest (ROI. We propose a local ROI imaging method with internal electrodes developed from careful analysis of the sensitivity matrix that is designed to reduce the sensitivity of the voxels outside the local region and optimize the sensitivity of the voxel inside the local region. We perform numerical simulations and physical measurements to demonstrate the localized EIT imaging method. In preliminary results with multiple objects we show the benefits of using an internal electrode and the improved resolution due to the local ROI image reconstruction method. The sensitivity is further increased by allowing the surface electrodes to be unevenly spaced with a higher density of surface electrodes near the ROI. Also, we analyse how much the image quality is improved using several performance parameters for comparison. While these have not yet been studied in depth, it convincingly shows an improvement in local sensitivity in images obtained with an internal electrode in comparison to a standard reconstruction method.

  5. Comparison of aquifer characteristics derived from local and regional aquifer tests.

    Science.gov (United States)

    Randolph, R.B.; Krause, R.E.; Maslia, M.L.

    1985-01-01

    A comparison of the aquifer parameter values obtained through the analysis of a local and a regional aquifer test involving the same area in southeast Georgia is made in order to evaluate the validity of extrapolating local aquifer-test results for use in large-scale flow simulations. Time-drawdown and time-recovery data were analyzed by using both graphical and least-squares fitting of the data to the Theis curve. Additionally, directional transmissivity, transmissivity tensor, and angle of anisotropy were computed for both tests. -from Authors Georgia drawdown transmissivity regional aquifer tests

  6. The relative importance of regional, local, and evolutionary factors structuring cryptobenthic coral-reef assemblages

    Science.gov (United States)

    Ahmadia, Gabby N.; Tornabene, Luke; Smith, David J.; Pezold, Frank L.

    2018-03-01

    Factors shaping coral-reef fish species assemblages can operate over a wide range of spatial scales (local versus regional) and across both proximate and evolutionary time. Niche theory and neutral theory provide frameworks for testing assumptions and generating insights about the importance of local versus regional processes. Niche theory postulates that species assemblages are an outcome of evolutionary processes at regional scales followed by local-scale interactions, whereas neutral theory presumes that species assemblages are formed by largely random processes drawing from regional species pools. Indo-Pacific cryptobenthic coral-reef fishes are highly evolved, ecologically diverse, temporally responsive, and situated on a natural longitudinal diversity gradient, making them an ideal group for testing predictions from niche and neutral theories and effects of regional and local processes on species assemblages. Using a combination of ecological metrics (fish density, diversity, assemblage composition) and evolutionary analyses (testing for phylogenetic niche conservatism), we demonstrate that the structure of cryptobenthic fish assemblages can be explained by a mixture of regional factors, such as the size of regional species pools and broad-scale barriers to gene flow/drivers of speciation, coupled with local-scale factors, such as the relative abundance of specific microhabitat types. Furthermore, species of cryptobenthic fishes have distinct microhabitat associations that drive significant differences in assemblage community structure between microhabitat types, and these distinct microhabitat associations are phylogenetically conserved over evolutionary timescales. The implied differential fitness of cryptobenthic fishes across varied microhabitats and the conserved nature of their ecology are consistent with predictions from niche theory. Neutral theory predictions may still hold true for early life-history stages, where stochastic factors may be more

  7. Effects of large-scale deforestation on precipitation in the monsoon regions: remote versus local effects.

    Science.gov (United States)

    Devaraju, N; Bala, Govindasamy; Modak, Angshuman

    2015-03-17

    In this paper, using idealized climate model simulations, we investigate the biogeophysical effects of large-scale deforestation on monsoon regions. We find that the remote forcing from large-scale deforestation in the northern middle and high latitudes shifts the Intertropical Convergence Zone southward. This results in a significant decrease in precipitation in the Northern Hemisphere monsoon regions (East Asia, North America, North Africa, and South Asia) and moderate precipitation increases in the Southern Hemisphere monsoon regions (South Africa, South America, and Australia). The magnitude of the monsoonal precipitation changes depends on the location of deforestation, with remote effects showing a larger influence than local effects. The South Asian Monsoon region is affected the most, with 18% decline in precipitation over India. Our results indicate that any comprehensive assessment of afforestation/reforestation as climate change mitigation strategies should carefully evaluate the remote effects on monsoonal precipitation alongside the large local impacts on temperatures.

  8. Special Features of Strain Localization and Nanodipoles of Partial Disclinations in the Region of Elastic Distortions

    Science.gov (United States)

    Tyumentsev, A. N.; Ditenberg, I. A.; Sukhanov, I. I.

    2018-02-01

    In the zones of strain localization in the region of elastic distortions and nanodipoles of partial disclinations representing the defects of elastically deformed medium, a theoretical analysis of the elastically stressed state and the energy of these defects, including the cases of their transformation into more complex ensembles of interrelated disclinations, is performed. Using the analytical results, the mechanisms of strain localization are discussed in the stages of nucleation and propagation of the bands of elastic and plastic strain localization formed in these zones (including the cases of nanocrystalline structure formation).

  9. Internal Associations of the Acidic Region of Upstream Binding Factor Control Its Nucleolar Localization.

    Science.gov (United States)

    Ueshima, Shuhei; Nagata, Kyosuke; Okuwaki, Mitsuru

    2017-11-15

    Upstream binding factor (UBF) is a member of the high-mobility group (HMG) box protein family, characterized by multiple HMG boxes and a C-terminal acidic region (AR). UBF is an essential transcription factor for rRNA genes and mediates the formation of transcriptionally active chromatin in the nucleolus. However, it remains unknown how UBF is specifically localized to the nucleolus. Here, we examined the molecular mechanisms that localize UBF to the nucleolus. We found that the first HMG box (HMG box 1), the linker region (LR), and the AR cooperatively regulate the nucleolar localization of UBF1. We demonstrated that the AR intramolecularly associates with and attenuates the DNA binding activity of HMG boxes and confers the structured DNA preference to HMG box 1. In contrast, the LR was found to serve as a nuclear localization signal and compete with HMG boxes to bind the AR, permitting nucleolar localization of UBF1. The LR sequence binds DNA and assists the stable chromatin binding of UBF. We also showed that the phosphorylation status of the AR does not clearly affect the localization of UBF1. Our results strongly suggest that associations of the AR with HMG boxes and the LR regulate UBF nucleolar localization. Copyright © 2017 American Society for Microbiology.

  10. Including local rainfall dynamics and uncertain boundary conditions into a 2-D regional-local flood modelling cascade

    Science.gov (United States)

    Bermúdez, María; Neal, Jeffrey C.; Bates, Paul D.; Coxon, Gemma; Freer, Jim E.; Cea, Luis; Puertas, Jerónimo

    2016-04-01

    Flood inundation models require appropriate boundary conditions to be specified at the limits of the domain, which commonly consist of upstream flow rate and downstream water level. These data are usually acquired from gauging stations on the river network where measured water levels are converted to discharge via a rating curve. Derived streamflow estimates are therefore subject to uncertainties in this rating curve, including extrapolating beyond the maximum observed ratings magnitude. In addition, the limited number of gauges in reach-scale studies often requires flow to be routed from the nearest upstream gauge to the boundary of the model domain. This introduces additional uncertainty, derived not only from the flow routing method used, but also from the additional lateral rainfall-runoff contributions downstream of the gauging point. Although generally assumed to have a minor impact on discharge in fluvial flood modeling, this local hydrological input may become important in a sparse gauge network or in events with significant local rainfall. In this study, a method to incorporate rating curve uncertainty and the local rainfall-runoff dynamics into the predictions of a reach-scale flood inundation model is proposed. Discharge uncertainty bounds are generated by applying a non-parametric local weighted regression approach to stage-discharge measurements for two gauging stations, while measured rainfall downstream from these locations is cascaded into a hydrological model to quantify additional inflows along the main channel. A regional simplified-physics hydraulic model is then applied to combine these inputs and generate an ensemble of discharge and water elevation time series at the boundaries of a local-scale high complexity hydraulic model. Finally, the effect of these rainfall dynamics and uncertain boundary conditions are evaluated on the local-scale model. Improvements in model performance when incorporating these processes are quantified using observed

  11. Local field radiotherapy without elective nodal irradiation for postoperative loco-regional recurrence of esophageal cancer.

    Science.gov (United States)

    Kimoto, Takuya; Yamazaki, Hideya; Suzuki, Gen; Aibe, Norihiro; Masui, Koji; Tatekawa, Kotoha; Sasaki, Naomi; Fujiwara, Hitoshi; Shiozaki, Atsushi; Konishi, Hirotaka; Nakamura, Satoaki; Yamada, Kei

    2017-09-01

    Radiotherapy is an effective treatment for the postoperative loco-regional recurrence of esophageal cancer; however, the optimal treatment field remains controversial. This study aims to evaluate the outcome of local field radiotherapy without elective nodal irradiation for postoperative loco-regional recurrence of esophageal cancer. We retrospectively investigated 35 patients treated for a postoperative loco-regional recurrence of esophageal cancer with local field radiotherapy between December 2008 and March 2016. The median irradiation dose was 60 Gy (range: 50-67.5 Gy). Thirty-one (88.6%) patients received concurrent chemotherapy. The median follow-up period was 18 months (range: 5-94 months). The 2-year overall survival was 55.7%, with a median survival time of 29.9 months. In the univariate analysis, the maximal diameter ≤20 mm (P = 0.0383), solitary lesion (P = 0.0352), and the complete remission after treatment (P = 0.00411) had a significantly better prognosis. A total of 27 of 35 patients (77.1%) had progressive disease (loco-regional failure [n = 9], distant metastasis [n = 7], and both loco-regional failure and distant metastasis [n = 11]). No patients had Grade 3 or greater mucositis. Local field radiotherapy is a considerable treatment option for postoperative loco-regional recurrence of esophageal cancer. © The Author 2017. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com

  12. Capital Humano:Su Definicion y Alcances en el Desarrollo Local y Regional Human Capital: its definition and scope in the Local and Regional Development

    Directory of Open Access Journals (Sweden)

    Iván Navarro Abarzúa

    2005-08-01

    Full Text Available El concepto Capital Humano es descrito y analizado en este trabajo como un auxiliar metodológico que, depurado de sus definiciones mecanicistas y neoliberales, ayuda a vincular la teoría, con la práctica en el análisis específico de una realidad territorial. Se trata de superar los modelos teóricos globales del análisis social, que generalmente subutilizan los datos empíricos que provee el territorio, cayendo en generalizaciones y abstracciones que poco ayudan. Sin embargo, este análisis tampoco se queda en la casuística, sino que culmina en propuestas que buscan contribuir al desarrollo de la teoría sobre Capital Humano y su impacto en el desarrollo regional y local. This article describes and analyzes the concept of Human Capital nor in a mechanical way nor using the neo-liberal definitions, but by linking the theory with practice in an specific territorial analysis. This is about superseding global theoretical models of social analysis, which generally sub-utilize the empirical data provided by territorial analysis, often falling into unhelpful generalizations and abstractions. Furthermore, this analysis is not centered in establishing causality, and it aims to be a contribution in the development of a theory of Human Capital and its impacts in the regional and local development.

  13. Local and regional variation in the monoterpenes of ponderosa pine wood oleoresin

    Science.gov (United States)

    R.H. Smith; R.L. Peloquin; P.C. Passof

    1969-01-01

    A gas chromatographic analysis of the mono-terpenes of 927 ponderosa pines, representing to some degree a major portion of the species' range, showed considerable local and regional diversity in composition. Five major monoterpenes— α-pinene, β-pinene, 3-carene, myrcene, and limonene—were analyzed. There is some evidence to support the...

  14. Use of survey data to define regional and local priorities for management on national wildlife refuges

    Science.gov (United States)

    John R. Sauer; Jennifer Casey; Harold Laskowski; Jan D. Taylor; Jane Fallon

    2005-01-01

    National Wildlife Refuges must manage habitats to support a variety of species that often have conflicting needs. To make reasonable management decisions, managers must know what species are priorities for their refuges and the relative importance of the species. Unfortunately, species priorities are often set regionally, but refuges must develop local priorities that...

  15. Local perspectives on global tourism in the Asia-Pacific region [introduction

    NARCIS (Netherlands)

    Dahles, H.; Meijl, A.H.M. van

    1999-01-01

    The articles brought together in this special issue of the IIAS Newsletter are centered on the question of how people at the grassroots level in the Asia-Pacific region have responded to international tourism. In view of the widespread negative view of the potential impact of tourism on local

  16. Standardizzazione e validazione dei dati della pianificazione urbanistica locale nella regione del Veneto

    Directory of Open Access Journals (Sweden)

    Francesco Tomaello

    2013-06-01

    their GIS datasets using a web service so the data uploaded by Municipalities into the Central GeoDatabase of Region Veneto’s SDI will be ready for automated mosaicking , remodelling (using local data models and INSPIRE Land Use data model and SDI-sharing.

  17. Local Road Safety Peer Exchange - Region 1 : An RSPCB Peer Exchange

    Science.gov (United States)

    2012-10-01

    This report provides a summary of the proceedings of the Local Road Safety Peer Exchange held in Piscataway, New Jersey October 10th and 11th, 2012. The Federal Highway Administration (FHWA) sponsored the Peer Exchange in coordination with Region 1 L...

  18. Modelling the impact of regional uplift and local tectonics on fluvial terrace preservation.

    NARCIS (Netherlands)

    Viveen, W.; Schoorl, J.M.; Veldkamp, A.; Balen, van R.T.

    2014-01-01

    A terrace formation model (TERRACE) combined with a longitudinal river profile model (FLUVER) was used to simulate fluvial terrace formation and preservation in the northwest Iberian lower Miño River basin under the influence of three tectonic conditions; namely regional vertical uplift, local basin

  19. Enhancement of bone shadow region using local phase-based ultrasound transmission maps.

    Science.gov (United States)

    Hacihaliloglu, Ilker

    2017-06-01

    Ultrasound is increasingly being employed in different orthopedic procedures as an imaging modality for real-time guidance. Nevertheless, low signal-to-noise-ratio and different imaging artifacts continue to hamper the success of ultrasound-based procedures. Bone shadow region is an important feature indicating the presence of bone/tissue interface in the acquired ultrasound data. Enhancement and automatic detection of this region could improve the sensitivity of ultrasound for imaging bone and result in improved guidance for various orthopedic procedures. In this work, a method is introduced for the enhancement of bone shadow regions from B-mode ultrasound data. The method is based on the combination of three different image phase features: local phase tensor, local weighted mean phase angle, and local phase energy. The combined local phase image features are used as an input to an [Formula: see text] norm-based contextual regularization method which emphasizes uncertainty in the shadow regions. The enhanced bone shadow images are automatically segmented and compared against expert segmentation. Qualitative and quantitative validation was performed on 100 in vivo US scans obtained from five subjects by scanning femur and vertebrae bones. Validation against expert segmentation achieved a mean dice similarity coefficient of 0.88. The encouraging results obtained in this initial study suggest that the proposed method is promising enough for further evaluation. The calculated bone shadow maps could be incorporated into different ultrasound bone segmentation and registration approaches as an additional feature.

  20. Articaine: a review of its use for local and regional anesthesia

    Science.gov (United States)

    Snoeck, Marc

    2012-01-01

    Articaine is an intermediate-potency, short-acting amide local anesthetic with a fast metabolism due to an ester group in its structure. It is effective with local infiltration or peripheral nerve block in dentistry, when administered as a spinal, epidural, ocular, or regional nerve block, or when injected intravenously for regional anesthesia. In comparative trials, its clinical effects were not generally significantly different from those of other short-acting local anesthetics like lidocaine, prilocaine, and chloroprocaine, and there is no conclusive evidence demonstrating above-average neurotoxicity. Articaine proved to be suitable and safe for procedures requiring a short duration of action in which a fast onset of anesthesia is desired, eg, dental procedures and ambulatory spinal anesthesia, in normal and in special populations. PMID:22915899

  1. Strategic trade between two regions with partial local consumer protection - General setup and nash equilibria

    Science.gov (United States)

    Iordanov, Iordan V.; Vassilev, Andrey A.

    2017-12-01

    We construct a model of the trade relations between two regions for the case when the trading entities (consumers) compete for a scarce good and there is an element of strategic interdependence in the trading process. Additionally, local consumers enjoy partial protection in the form of guaranteed access to a part of the locally-supplied quantity of the good. The model is formulated for the general asymmetric case, where the two regions differ in terms of parameters such as income, size of the local market supply, degree of protection and transportation costs. For this general model we establish the existence of Nash equilibria and obtain their form as a function of the model parameters, producing a typology of the equilibria. This is a required step in order to rigorously study various types of price dynamics for the model.

  2. The Conceptual Approaches to Strategic Management of Region Using the Spatially Localized Agrarian Economic Systems

    Directory of Open Access Journals (Sweden)

    Petrenko Natalia О.

    2017-10-01

    Full Text Available The article is aimed at improving the theoretical and methodical provisions of the cluster approach to development of the spatially localized systems of the agricultural sector of Ukrainian economy at the regional level. Based on generalizing the relevant theoretical provisions, the identified characteristics of formation and development of the spatially localized systems, it has been found that, originating in the form of economic growth zones, they have been transformed into clustered and subclustered forms. It has been indicated that a prospective form of further development of the spatially localized systems is formation of subclustered structures that take account of the established specialization of localities, appropriate infrastructure, resource availability. The possibility of creating a project of developing a cluster formation was discussed on the example of the Central Economic Area. A complex of basic requirements for the intended localization of the cluster has been formulated. Proceeding from the results of the study, practical proposals for strategic management of region have been developed on the basis of development of cluster formations, using the spatially localized agrarian economic systems.

  3. Assessment of the results of the strategic orientation on regional and local products in food retail

    Directory of Open Access Journals (Sweden)

    Kamil Pícha

    2013-01-01

    Full Text Available The aim of this paper is to assess if there is a difference in food choice behaviour between regular customers of stores of the retail chain Terno and other consumers. Consequently, the paper aims to discover, if the strategy formulated by the consumer co-operative Jednota České Budějovice was a good strategy. The core of this strategy is the orientation on the region, local and regional food and food products and the co-operation with local small and medium suppliers. Another part of this strategy is also the permanent control of quality of these products and creation of the special private label – Quality food from our region. The consumer co-operative co-operates also with the regional grouping under another label – Tastes great. Southbohemian. The assessment is done by means of the analysis of a questionnaire survey that was done among consumers in the South Bohemia in 2011. The strongest factor differentiating customers of the retail chain TERNO from other consumer is the orientation on regional or local products, which explains about 41% of variability. Other differentiating factors are environment-friendly production and selling and quality of food. All these three factors explain in total 66.5% of variability of the data set.

  4. Localization of insulinomas to regions of the pancreas by intraarterial calcium stimulation: the NIH experience.

    Science.gov (United States)

    Guettier, Jean-Marc; Kam, Anthony; Chang, Richard; Skarulis, Monica C; Cochran, Craig; Alexander, H Richard; Libutti, Steven K; Pingpank, James F; Gorden, Phillip

    2009-04-01

    Selective intraarterial calcium injection of the major pancreatic arteries with hepatic venous sampling [calcium arterial stimulation (CaStim)] has been used as a localizing tool for insulinomas at the National Institutes of Health (NIH) since 1989. The accuracy of this technique for localizing insulinomas was reported for all cases until 1996. The aim of the study was to assess the accuracy and track record of the CaStim over time and in the context of evolving technology and to review issues related to result interpretation and procedure complications. CaStim was the only invasive preoperative localization modality used at our center. Endoscopic ultrasound (US) was not studied. We conducted a retrospective case review at a referral center. Twenty-nine women and 16 men (mean age, 47 yr; range, 13-78) were diagnosed with an insulinoma from 1996-2008. A supervised fast was conducted to confirm the diagnosis of insulinoma. US, computed tomography (CT), magnetic resonance imaging (MRI), and CaStim were used as preoperative localization studies. Localization predicted by each preoperative test was compared to surgical localization for accuracy. We measured the accuracy of US, CT, MRI, and CaStim for localization of insulinomas preoperatively. All 45 patients had surgically proven insulinomas. Thirty-eight of 45 (84%) localized to the correct anatomical region by CaStim. In five of 45 (11%) patients, the CaStim was falsely negative. Two of 45 (4%) had false-positive localizations. The CaStim has remained vastly superior to abdominal US, CT, or MRI over time as a preoperative localizing tool for insulinomas. The utility of the CaStim for this purpose and in this setting is thus validated.

  5. 3-D crustal P-wave velocity tomography of the Italian region using local and regional seismicity data

    Directory of Open Access Journals (Sweden)

    F. M. Mele

    1995-06-01

    Full Text Available A tomographic experiment was performed in the Italian region using local and regional arrivaI times of p and S seismological phases selected from the Italian National Bulletin in the time interval 1984-1991. We deter- mined a 3-D crustal P-wave velocity model using a simultaneous inversion method that iteratively re1ocates the hypocenters and computes the unknown model parameters. A fast two-point ray tracing algorithm was adopted to compute the ray paths and travel times of P", S", P g' Sg phases with good accuracy. Synthetic tests were performed using the "true" hypocenter and station distribution to rough1y evaluate the extension of the areas most densely spanned by the ray paths; the agreement between synthetic and computed models is more satisfactory at Moho depths than in the upper crust. The qua1ity of the model resulting from inversion of real data is examined by the ca1culation of the Spread Function (Toomey and Foulger, 1989. The 3-D crustal P-wave velocity mode1 of the Italian region shows remarkab1e trends at Moho depths: the areas east of the Apennines call for positive adjustments of the initial velocity va1ue, while the west region shows negative ad- justments. The correspondence among the main features of the velocity field, the map of Moho isobaths and the map of the gravity anoma1ies is also outlined.

  6. Insight on invasions and resilience derived from spatiotemporal discontinuities of biomass at local and regional scales

    Science.gov (United States)

    Angeler, David G.; Allen, Criag R.; Johnson, Richard K.

    2012-01-01

    Understanding the social and ecological consequences of species invasions is complicated by nonlinearities in processes, and differences in process and structure as scale is changed. Here we use discontinuity analyses to investigate nonlinear patterns in the distribution of biomass of an invasive nuisance species that could indicate scale-specific organization. We analyze biomass patterns in the flagellate Gonyostomum semen (Raphidophyta) in 75 boreal lakes during an 11-year period (1997-2007). With simulations using a unimodal null model and cluster analysis, we identified regional groupings of lakes based on their biomass patterns. We evaluated the variability of membership of individual lakes in regional biomass groups. Temporal trends in local and regional discontinuity patterns were analyzed using regressions and correlations with environmental variables that characterize nutrient conditions, acidity status, temperature variability, and water clarity. Regionally, there was a significant increase in the number of biomass groups over time, indicative of an increased number of scales at which algal biomass organizes across lakes. This increased complexity correlated with the invasion history of G. semen and broad-scale environmental change (recovery from acidification). Locally, no consistent patterns of lake membership to regional biomass groups were observed, and correlations with environmental variables were lake specific. The increased complexity of regional biomass patterns suggests that processes that act within or between scales reinforce the presence of G. semen and its potential to develop high-biomass blooms in boreal lakes. Emergent regional patterns combined with locally stochastic dynamics suggest a bleak future for managing G. semen, and more generally why invasive species can be ecologically successful.

  7. Alimentary tract absorption (f1 values) for radionuclides in local and regional fallout from nuclear tests.

    Science.gov (United States)

    Ibrahim, Shawki A; Simon, Steven L; Bouville, André; Melo, Dunstana; Beck, Harold L

    2010-08-01

    This paper presents gastrointestinal absorption fractions (f1 values) for estimating internal doses from local and regional fallout radionuclides due to nuclear tests. The choice of f1 values are based on specific circumstances of weapons test conditions and a review of reported f1 values for elements in different physical and chemical states. Special attention is given to fallout from nuclear tests conducted at the Marshall Islands. We make a distinction between the f1 values for intakes of radioactive materials immediately after deposition (acute intakes) and intakes that occur in the course of months and years after deposition, following incorporation into terrestrial and aquatic foodstuffs (chronic intakes). Multiple f1 values for different circumstances where persons are exposed to radioactive fallout (e.g., local vs. regional fallout and coral vs. continental tests) are presented when supportive information is available. In some cases, our selected f1 values are similar to those adopted by the International Commission on Radiological Protection (ICRP) (e.g., iodine and most actinides). However, f1 values for cesium and strontium derived from urine bioassay data of the Marshallese population are notably lower than the generic f1 values recommended by ICRP, particularly for acute intakes from local fallout (0.4 and 0.05 for Cs and Sr, respectively). The f1 values presented here form the first complete set of values relevant to realistic dose assessments for exposure to local or regional radioactive fallout.

  8. Chorus source region localization in the Earth's outer magnetosphere using THEMIS measurements

    Directory of Open Access Journals (Sweden)

    O. Agapitov

    2010-06-01

    Full Text Available Discrete ELF/VLF chorus emissions, the most intense electromagnetic plasma waves observed in the Earth's radiation belts and outer magnetosphere, are thought to propagate roughly along magnetic field lines from a localized source region near the magnetic equator towards the magnetic poles. THEMIS project Electric Field Instrument (EFI and Search Coil Magnetometer (SCM measurements were used to determine the spatial scale of the chorus source localization region on the day side of the Earth's outer magnetosphere. We present simultaneous observations of the same chorus elements registered onboard several THEMIS spacecraft in 2007 when all the spacecraft were in the same orbit. Discrete chorus elements were observed at 0.15–0.25 of the local electron gyrofrequency, which is typical for the outer magnetosphere. We evaluated the Poynting flux and wave vector distribution and obtained chorus wave packet quasi-parallel propagation to the local magnetic field. Amplitude and phase correlation data analysis allowed us to estimate the characteristic spatial correlation scale transverse to the local magnetic field to be in the 2800–3200 km range.

  9. Local Perceptions of Corporate Social Responsibility for Arctic Petroleum in the Barents Region

    Directory of Open Access Journals (Sweden)

    Ilan Kelman

    2016-11-01

    Full Text Available Corporate social responsibility (CSR is promoted and critiqued by many players involved in or opposed to petroleum exploration and extraction, although a common understanding of CSR's theoretical and practical meanings rarely exists. This paper uses Arctic petroleum in the Barents region (Norway and Russia to investigate local perceptions of CSR. We conducted open-ended, semi-structured interviews in four locations: Hammerfest, Murmansk, Komi Republic, and Nenets Autonomous Okrug (NAO. Interviewees included the local population, regional and local authorities, non-governmental organisations (NGOs, and petroleum company representatives. The field research suggests that those who gain directly from the petroleum industry and do not directly experience negative impacts were more inclined to be positive about the industry, although overall, general support for petroleum activity was high. In some cases, positive economic benefits resulted in greater tolerance of environmental risk. Sometimes, the industry and government were criticised by locals for failing to support a more equitable distribution of broader economic benefits. Rather than splitting along for-profit/NGO or indigenous/non-indigenous lines, our analysis suggests that those who are closer to the petroleum industry or its benefits, termed ‘insiders’, tend to be more positive than ‘outsiders’. This study is perhaps the first of its kind in its focus on local perceptions of CSR for Arctic petroleum across the Barents region. The findings of this study not only match with that of the previous literature on Arctic petroleum but also provide further practical and theoretical insights by indicating subtleties and nuances within the localities examined.

  10. Local anaesthetic toxicity in a pregnant patient undergoing lignocaine-induced intravenous regional anaesthesia.

    LENUS (Irish Health Repository)

    Coleman, M

    2012-02-03

    A pregnant patient at 38 weeks\\' gestation developed symptoms of local anaesthetic toxicity following intravenous regional anaesthesia (IVRA) for hand surgery, using a standard dose of lignocaine. Reports suggest that a number of factors, both physiological and pharmacological, combine to increase the likelihood of local anaesthetic (LA) toxicity in pregnancy despite employment of a conventional "safe" IVRA technique. It is suggested that for IVRA, pregnant patients are premedicated with a benzodiazepine, the tourniquet time is increased and the concentration of LA is decreased to reduce the risks of LA toxicity.

  11. C-terminal region of herpes simplex virus ICP8 protein needed for intranuclear localization

    International Nuclear Information System (INIS)

    Taylor, Travis J; Knipe, David M.

    2003-01-01

    The herpes simplex virus single-stranded DNA-binding protein, ICP8, localizes initially to structures in the nucleus called prereplicative sites. As replication proceeds, these sites mature into large globular structures called replication compartments. The details of what signals or proteins are involved in the redistribution of viral and cellular proteins within the nucleus between prereplicative sites and replication compartments are poorly understood; however, we showed previously that the dominant-negative d105 ICP8 does not localize to prereplicative sites and prevents the localization of other viral proteins to prereplicative sites (J. Virol. 74 (2000) 10122). Within the residues deleted in d105 (1083 to 1168), we identified a region between amino acid residues 1080 and 1135 that was predicted by computer models to contain two α-helices, one with considerable amphipathic nature. We used site-specific and random mutagenesis techniques to identify residues or structures within this region that are required for proper ICP8 localization within the nucleus. Proline substitutions in the predicted helix generated ICP8 molecules that did not localize to prereplicative sites and acted as dominant-negative inhibitors. Other substitutions that altered the charged residues in the predicted α-helix to alanine or leucine residues had little or no effect on ICP8 intranuclear localization. The predicted α-helix was dispensable for the interaction of ICP8 with the U L 9 origin-binding protein. We propose that this C-terminal α-helix is required for localization of ICP8 to prereplicative sites by binding viral or cellular factors that target or retain ICP8 at specific intranuclear sites

  12. Local and regional smokefree and tobacco-free action in New Zealand: highlights and directions.

    Science.gov (United States)

    Thomson, George; Wilson, Nick

    2017-09-22

    In this viewpoint we highlight and discuss some recent local and regional level advances in tobacco control in Aotearoa/New Zealand. In this country a wide range of local actors are helping drive smokefree and tobacco-free policies, with an increasing presence of businesses in this field. There has been progress in the areas of smokefree dining, large outdoor worksites and ski fields, and parts of downtown areas such as squares and streets. In 2015 and 2016, three councils (Palmerston North, Napier and Hastings) have used pavement lease policies and bylaws to start introducing an element of requirement into smokefree outdoor dining. Elsewhere (eg, Rotorua, Ashburton, Westland and Christchurch) significant smokefree outdoor dining moves have been made by, or in conjunction with, local councils. Tobacco-free retailing continues to expand, particularly in Northland. In the absence of meaningful central government action on smokefree places in the last decade (despite the Smokefree 2025 goal), local activity is leading the way. It is particularly important in providing models for smokefree outdoor hospitality areas, where smoking normalisation and relapse are significant health risks. Nevertheless, there is a need for the local smokefree and tobacco-free activity to be nationally evaluated, particularly for assessing the prevalence of smoking in areas covered by 'smokefree' policies. Action by central government could help local actors by providing a more definite legislative basis for bylaws, by minimum outdoor smokefree laws and by the funding of effective tobacco control mass media.

  13. Life-history strategies associated with local population variability confer regional stability.

    Science.gov (United States)

    Pribil, Stanislav; Houlahan, Jeff E

    2003-07-07

    A widely held ecological tenet is that, at the local scale, populations of K-selected species (i.e. low fecundity, long lifespan and large body size) will be less variable than populations of r-selected species (i.e. high fecundity, short lifespan and small body size). We examined the relationship between long-term population trends and life-history attributes for 185 bird species in the Czech Republic and found that, at regional spatial scales and over moderate temporal scales (100-120 years), K-selected bird species were more likely to show both large increases and decreases in population size than r-selected species. We conclude that life-history attributes commonly associated with variable populations at the local scale, confer stability at the regional scale.

  14. Active Contour Driven by Local Region Statistics and Maximum A Posteriori Probability for Medical Image Segmentation

    Directory of Open Access Journals (Sweden)

    Xiaoliang Jiang

    2014-01-01

    Full Text Available This paper presents a novel active contour model in a variational level set formulation for simultaneous segmentation and bias field estimation of medical images. An energy function is formulated based on improved Kullback-Leibler distance (KLD with likelihood ratio. According to the additive model of images with intensity inhomogeneity, we characterize the statistics of image intensities belonging to each different object in local regions as Gaussian distributions with different means and variances. Then, we use the Gaussian distribution with bias field as a local region descriptor in level set formulation for segmentation and bias field correction of the images with inhomogeneous intensities. Therefore, image segmentation and bias field estimation are simultaneously achieved by minimizing the level set formulation. Experimental results demonstrate desirable performance of the proposed method for different medical images with weak boundaries and noise.

  15. Quantifying regional changes in terrestrial carbon storage by extrapolation from local ecosystem models

    Energy Technology Data Exchange (ETDEWEB)

    King, A W

    1991-12-31

    A general procedure for quantifying regional carbon dynamics by spatial extrapolation of local ecosystem models is presented Monte Carlo simulation to calculate the expected value of one or more local models, explicitly integrating the spatial heterogeneity of variables that influence ecosystem carbon flux and storage. These variables are described by empirically derived probability distributions that are input to the Monte Carlo process. The procedure provides large-scale regional estimates based explicitly on information and understanding acquired at smaller and more accessible scales.Results are presented from an earlier application to seasonal atmosphere-biosphere CO{sub 2} exchange for circumpolar ``subarctic`` latitudes (64{degree}N-90{degree}N). Results suggest that, under certain climatic conditions, these high northern ecosystems could collectively release 0.2 Gt of carbon per year to the atmosphere. I interpret these results with respect to questions about global biospheric sinks for atmospheric CO{sub 2} .

  16. TRANSPARENCY OF LOCAL BUDGETS IN THE NORTH-WEST REGION OF ROMANIA

    Directory of Open Access Journals (Sweden)

    Pintea Mirela-Oana

    2013-07-01

    Full Text Available The central researched element in our paper is the local budgets, the basic component of local public finances. Local budgets, like any other budgets, are the most important tool for the management (of local governments planning, forecasting, implementing and monitoring the results of administrative-territorial units activity, also being an appropriate tool for enhancing performance. A budget is the government's plan regarding the use of public resources to meet the citizens' needs. The aim of this paper is to realize a research on budget transparency in local governments from the Nord-West Region of Romania, regarding the availability of the budget information on the websites of the county councils and the county residences. The key element of good governance in today global economic environment is transparency that can be defined as the openness of public authorities (central and local regarding their policy intention, formulation and implementation. For local governments budget transparency is an important issue, due to the growing role of administrative-territorial units, confirmed over time by the economic reality. The importance of local budgets has increased in recent years due to the need to improve management efficiency and accounting al the level of local governments. Not only policy makers but also the citizens need information regarding local government current activities, expenditures, development projects and policies. In this context of a growing need for information, the transparency of local budgets is a mandatory condition for any local government. The combination of budget transparency and public participation in budget processes has the potential to combat corruption, foster public accountability of government agencies and contribute to judicious use of public funds. In this context, budget transparency represents the mean through which ordinary citizens and civil society organizations can access information about the

  17. Regional Distribution Shifts Help Explain Local Changes in Wintering Raptor Abundance: Implications for Interpreting Population Trends

    Science.gov (United States)

    Paprocki, Neil; Heath, Julie A.; Novak, Stephen J.

    2014-01-01

    Studies of multiple taxa across broad-scales suggest that species distributions are shifting poleward in response to global climate change. Recognizing the influence of distribution shifts on population indices will be an important part of interpreting trends within management units because current practice often assumes that changes in local populations reflect local habitat conditions. However, the individual- and population-level processes that drive distribution shifts may occur across a large, regional scale and have little to do with the habitats within the management unit. We examined the latitudinal center of abundance for the winter distributions of six western North America raptor species using Christmas Bird Counts from 1975–2011. Also, we considered whether population indices within western North America Bird Conservation Regions (BCRs) were explained by distribution shifts. All six raptors had significant poleward shifts in their wintering distributions over time. Rough-legged Hawks (Buteo lagopus) and Golden Eagles (Aquila chrysaetos) showed the fastest rate of change, with 8.41 km yr−1 and 7.74 km yr−1 shifts, respectively. Raptors may be particularly responsive to warming winters because of variable migration tendencies, intraspecific competition for nesting sites that drives males to winter farther north, or both. Overall, 40% of BCR population trend models were improved by incorporating information about wintering distributions; however, support for the effect of distribution on BCR indices varied by species with Rough-legged Hawks showing the most evidence. These results emphasize the importance of understanding how regional distribution shifts influence local-scale population indices. If global climate change is altering distribution patterns, then trends within some management units may not reflect changes in local habitat conditions. The methods used to monitor and manage bird populations within local BCRs will fundamentally change as

  18. Regional distribution shifts help explain local changes in wintering raptor abundance: implications for interpreting population trends.

    Directory of Open Access Journals (Sweden)

    Neil Paprocki

    Full Text Available Studies of multiple taxa across broad-scales suggest that species distributions are shifting poleward in response to global climate change. Recognizing the influence of distribution shifts on population indices will be an important part of interpreting trends within management units because current practice often assumes that changes in local populations reflect local habitat conditions. However, the individual- and population-level processes that drive distribution shifts may occur across a large, regional scale and have little to do with the habitats within the management unit. We examined the latitudinal center of abundance for the winter distributions of six western North America raptor species using Christmas Bird Counts from 1975-2011. Also, we considered whether population indices within western North America Bird Conservation Regions (BCRs were explained by distribution shifts. All six raptors had significant poleward shifts in their wintering distributions over time. Rough-legged Hawks (Buteo lagopus and Golden Eagles (Aquila chrysaetos showed the fastest rate of change, with 8.41 km yr(-1 and 7.74 km yr(-1 shifts, respectively. Raptors may be particularly responsive to warming winters because of variable migration tendencies, intraspecific competition for nesting sites that drives males to winter farther north, or both. Overall, 40% of BCR population trend models were improved by incorporating information about wintering distributions; however, support for the effect of distribution on BCR indices varied by species with Rough-legged Hawks showing the most evidence. These results emphasize the importance of understanding how regional distribution shifts influence local-scale population indices. If global climate change is altering distribution patterns, then trends within some management units may not reflect changes in local habitat conditions. The methods used to monitor and manage bird populations within local BCRs will fundamentally

  19. Predictors and Patterns of Local, Regional, and Distant Failure in Squamous Cell Carcinoma of the Vulva.

    Science.gov (United States)

    Bogani, Giorgio; Cromi, Antonella; Serati, Maurizio; Uccella, Stefano; Donato, Violante Di; Casarin, Jvan; Naro, Edoardo Di; Ghezzi, Fabio

    2017-06-01

    To identify factors predicting for recurrence in vulvar cancer patients undergoing surgical treatment. We retrospectively evaluated data of consecutive patients with squamous cell vulvar cancer treated between January 1, 1990 and December 31, 2013. Basic descriptive statistics and multivariable analysis were used to design predicting models influencing outcomes. Five-year disease-free survival (DFS) and overall survival (OS) were analyzed using the Cox model. The study included 101 patients affected by vulvar cancer: 64 (63%) stage I, 12 (12%) stage II, 20 (20%) stage III, and 5 (5%) stage IV. After a mean (SD) follow-up of 37.6 (22.1) months, 21 (21%) recurrences occurred. Local, regional, and distant failures were recorded in 14 (14%), 6 (6%), and 3 (3%) patients, respectively. Five-year DFS and OS were 77% and 82%, respectively. At multivariate analysis only stromal invasion >2 mm (hazard ratio: 4.9 [95% confidence interval, 1.17-21.1]; P=0.04) and extracapsular lymph node involvement (hazard ratio: 9.0 (95% confidence interval, 1.17-69.5); P=0.03) correlated with worse DFS, although no factor independently correlated with OS. Looking at factors influencing local and regional failure, we observed that stromal invasion >2 mm was the only factor predicting for local recurrence, whereas lymph node extracapsular involvement predicted for regional recurrence. Stromal invasion >2 mm and lymph node extracapsular spread are the most important factors predicting for local and regional failure, respectively. Studies evaluating the effectiveness of adjuvant treatment in high-risk patients are warranted.

  20. Level set segmentation of medical images based on local region statistics and maximum a posteriori probability.

    Science.gov (United States)

    Cui, Wenchao; Wang, Yi; Lei, Tao; Fan, Yangyu; Feng, Yan

    2013-01-01

    This paper presents a variational level set method for simultaneous segmentation and bias field estimation of medical images with intensity inhomogeneity. In our model, the statistics of image intensities belonging to each different tissue in local regions are characterized by Gaussian distributions with different means and variances. According to maximum a posteriori probability (MAP) and Bayes' rule, we first derive a local objective function for image intensities in a neighborhood around each pixel. Then this local objective function is integrated with respect to the neighborhood center over the entire image domain to give a global criterion. In level set framework, this global criterion defines an energy in terms of the level set functions that represent a partition of the image domain and a bias field that accounts for the intensity inhomogeneity of the image. Therefore, image segmentation and bias field estimation are simultaneously achieved via a level set evolution process. Experimental results for synthetic and real images show desirable performances of our method.

  1. Local region power spectrum-based unfocused ship detection method in synthetic aperture radar images

    Science.gov (United States)

    Wei, Xiangfei; Wang, Xiaoqing; Chong, Jinsong

    2018-01-01

    Ships on synthetic aperture radar (SAR) images will be severely defocused and their energy will disperse into numerous resolution cells under long SAR integration time. Therefore, the image intensity of ships is weak and sometimes even overwhelmed by sea clutter on SAR image. Consequently, it is hard to detect the ships from SAR intensity images. A ship detection method based on local region power spectrum of SAR complex image is proposed. Although the energies of the ships are dispersed on SAR intensity images, their spectral energies are rather concentrated or will cause the power spectra of local areas of SAR images to deviate from that of sea surface background. Therefore, the key idea of the proposed method is to detect ships via the power spectra distortion of local areas of SAR images. The local region power spectrum of a moving target on SAR image is analyzed and the way to obtain the detection threshold through the probability density function (pdf) of the power spectrum is illustrated. Numerical P- and L-band airborne SAR ocean data are utilized and the detection results are also illustrated. Results show that the proposed method can well detect the unfocused ships, with a detection rate of 93.6% and a false-alarm rate of 8.6%. Moreover, by comparing with some other algorithms, it indicates that the proposed method performs better under long SAR integration time. Finally, the applicability of the proposed method and the way of parameters selection are also discussed.

  2. How to maximally support local and regional biodiversity in applied conservation? Insights from pond management.

    Science.gov (United States)

    Lemmens, Pieter; Mergeay, Joachim; De Bie, Tom; Van Wichelen, Jeroen; De Meester, Luc; Declerck, Steven A J

    2013-01-01

    Biodiversity and nature values in anthropogenic landscapes often depend on land use practices and management. Evaluations of the association between management and biodiversity remain, however, comparatively scarce, especially in aquatic systems. Furthermore, studies also tend to focus on a limited set of organism groups at the local scale, whereas a multi-group approach at the landscape scale is to be preferred. This study aims to investigate the effect of pond management on the diversity of multiple aquatic organism groups (e.g. phytoplankton, zooplankton, several groups of macro-invertebrates, submerged and emergent macrophytes) at local and regional spatial scales. For this purpose, we performed a field study of 39 shallow man-made ponds representing five different management types. Our results indicate that fish stock management and periodic pond drainage are crucial drivers of pond biodiversity. Furthermore, this study provides insight in how the management of eutrophied ponds can contribute to aquatic biodiversity. A combination of regular draining of ponds with efforts to keep ponds free of fish seems to be highly beneficial for the biodiversity of many groups of aquatic organisms at local and regional scales. Regular draining combined with a stocking of fish at low biomass is also preferable to infrequent draining and lack of fish stock control. These insights are essential for the development of conservation programs that aim long-term maintenance of regional biodiversity in pond areas across Europe.

  3. TRANSPARENCY OF LOCAL AND REGIONAL SELF-GOVERNMENT IN THE PUBLICATION OF PROCUREMENT PLAN WEB SITE

    Directory of Open Access Journals (Sweden)

    Tomislav Šušnjar

    2016-12-01

    Full Text Available The main objective of this paper was to determine whether there is a Procurement Plan for 2016, on the website of local and regional selfgovernment units in the Republic of Croatia. After having applied the method of analysis, the hypothesis that local and regional self-governments in the Republic of Croatia fulfilled their legal obligation to publish the procurement plan to websites, was not confirmed. The research results show that all counties except for Međimurje County have a Procurement Plan for 2016 available on their respective websites. Out of the total of 127 cities in the Republic of Croatia, ten cities (Belišće, Čabar, Donji Miholjac, Drniš, Ilok, Imotski, Nova Gradiška, Pleternica, Popovača and Vrgorac did not publish their Procurement Plans for 2016. In addition, the survey results show that 61 municipalities do not have a published Procurement Plan for 2016 on their respective websites. This study may contribute to the knowledge of the local and regional self- government units’ websites contents in the Republic of Croatia, and encourage the employees to comply with the legal obligation to publish the procurement plan on their websites for the purpose of conducting transparent procurement.

  4. Local economic development in theories of regional economies and rural studies

    Directory of Open Access Journals (Sweden)

    Kačar Bahrija

    2016-01-01

    Full Text Available In this paper is a detailed analysis of the basics in the theory of economic development during the period from mid last century until today. It states the most significant theories, points out their ranges, offers a critical review regarding their treatment of development, especially regional, rural and local one. It observes those theories according to different classifications existing in scientific literature, primarily the ascend theory, stagnation theory, balanced economic growth theory; then, short-term and long-term development and growth theories; traditional and endogenous theories; economic growth stages theory emphasized after the WWII; structural changes theory; dependency theory, neo-classic counter-revolution theory and endogenous theory as a new growth theory. The analysis becomes wider with a study on development in regional economy theories and rural studies and it systematizes the classification of those theories according to regional economy academics. Distancing ourselves from any particular division as the most suitable and acceptable one, the theories are treated separately and in an historic context, in order to encircle the time framework which from modern theories, dealing with local level development difficulties, resulted. It asserts The Community-led Rural Development Theory, often referred to as the Community Development Theory, or marked as Bottom-up Partnership Approach. The analysis of development theories asserts that mixed exogenous - endogenous approach to development links the rural/local development to the globalization process mostly due to fast technology changes of the IT and communication sectors.

  5. Variabilidade local e regional da evapotranspiração estimada pelo algoritmo SEBAL Local and regional variability of evapotranspiration estimated by SEBAL algorithm

    Directory of Open Access Journals (Sweden)

    Luis C. J. Moreira

    2010-12-01

    Full Text Available Em face da importância em conhecer a evapotranspiração (ET para uso racional da água na irrigação no contexto atual de escassez desse recurso, algoritmos de estimativa da ET a nível regional foram desenvolvidos utilizando-se de ferramentas de sensoriamento remoto. Este estudo objetivou aplicar o algoritmo SEBAL (Surface Energy Balance Algorithms for Land em três imagens do satélite Landsat 5, do segundo semestre de 2006. As imagens correspondem a áreas irrigadas, floresta nativa densa e a Caatinga do Estado do Ceará (Baixo Acaraú, Chapada do Apodi e Chapada do Araripe. Este algoritmo calcula a evapotranspiração horária a partir do fluxo de calor latente, estimado como resíduo do balanço de energia na superfície. Os valores de ET obtidos nas três regiões foram superiores a 0,60 mm h-1 nas áreas irrigadas ou de vegetação nativa densa. As áreas de vegetação nativa menos densa apresentaram taxa da ET horária de 0,35 a 0,60 mm h-1, e valores quase nulos em áreas degradadas. A análise das médias de evapotranspiração horária pelo teste de Tukey a 5% de probabilidade permitiu evidenciar uma variabilidade significativa local, bem como regional no Estado do Ceará.In the context of water resources scarcity, the rational use of water for irrigation is necessary, implying precise estimations of the actual evapotranspiration (ET. With the recent progresses of remote-sensed technologies, regional algorithms estimating evapotranspiration from satellite observations were developed. This work aimed at applying the SEBAL algorithm (Surface Energy Balance Algorithms for Land at three Landsat-5 images during the second semester of 2006. These images cover irrigated areas, dense native forest areas and caatinga areas in three regions of the state of Ceará (Baixo Acaraú, Chapada do Apodi and Chapada do Araripe. The SEBAL algorithm calculates the hourly evapotranspiration from the latent heat flux, estimated from the surface energy

  6. Calculation of the Local Free Energy Landscape in the Restricted Region by the Modified Tomographic Method.

    Science.gov (United States)

    Chen, Changjun

    2016-03-31

    The free energy landscape is the most important information in the study of the reaction mechanisms of the molecules. However, it is difficult to calculate. In a large collective variable space, a molecule must take a long time to obtain the sufficient sampling during the simulation. To save the calculation quantity, decreasing the sampling region and constructing the local free energy landscape is required in practice. However, the restricted region in the collective variable space may have an irregular shape. Simply restricting one or more collective variables of the molecule cannot satisfy the requirement. In this paper, we propose a modified tomographic method to perform the simulation. First, it divides the restricted region by some hyperplanes and connects the centers of hyperplanes together by a curve. Second, it forces the molecule to sample on the curve and the hyperplanes in the simulation and calculates the free energy data on them. Finally, all the free energy data are combined together to form the local free energy landscape. Without consideration of the area outside the restricted region, this free energy calculation can be more efficient. By this method, one can further optimize the path quickly in the collective variable space.

  7. Malaria vectors in ecologically heterogeneous localities of the Colombian Pacific region.

    Directory of Open Access Journals (Sweden)

    Nelson Naranjo-Díaz

    Full Text Available The Colombian Pacific region is second nationally in number of malaria cases reported. This zone presents great ecological heterogeneity and Anopheles species diversity. However, little is known about the current spatial and temporal distribution of vector species. This study, conducted in three ecologically different localities of the Pacific region, aimed to evaluate the composition and distribution of Anopheles species and characterize transmission intensity. A total of 4,016 Anopheles mosquitoes were collected representing seven species. The composition and dominant species differed in each locality. Three species were infected with malaria parasites: Anopheles darlingi and An. calderoni were infected with Plasmodium falciparum and An. nuneztovari with Plasmodium vivax VK210 and VK247. Annual EIRs varied from 3.5-7.2 infective bites per year. These results confirm the importance of the primary vector An. nuneztovari in areas disturbed by human interventions, of An. darlingi in deforested margins of humid tropical rainforest and An. albimanus and the suspected vector An. calderoni in areas impacted by urbanization and large-scale palm oil agriculture close to the coast. This constitutes the first report in the Colombia Pacific region of naturally infected An. darlingi, and in Colombia of naturally infected An. calderoni. Further studies should evaluate the epidemiological importance of An. calderoni in the Pacific region.

  8. Local host specialization, host-switching, and dispersal shape the regional distributions of avian haemosporidian parasites.

    Science.gov (United States)

    Ellis, Vincenzo A; Collins, Michael D; Medeiros, Matthew C I; Sari, Eloisa H R; Coffey, Elyse D; Dickerson, Rebecca C; Lugarini, Camile; Stratford, Jeffrey A; Henry, Donata R; Merrill, Loren; Matthews, Alix E; Hanson, Alison A; Roberts, Jackson R; Joyce, Michael; Kunkel, Melanie R; Ricklefs, Robert E

    2015-09-08

    The drivers of regional parasite distributions are poorly understood, especially in comparison with those of free-living species. For vector-transmitted parasites, in particular, distributions might be influenced by host-switching and by parasite dispersal with primary hosts and vectors. We surveyed haemosporidian blood parasites (Plasmodium and Haemoproteus) of small land birds in eastern North America to characterize a regional parasite community. Distributions of parasite populations generally reflected distributions of their hosts across the region. However, when the interdependence between hosts and parasites was controlled statistically, local host assemblages were related to regional climatic gradients, but parasite assemblages were not. Moreover, because parasite assemblage similarity does not decrease with distance when controlling for host assemblages and climate, parasites evidently disperse readily within the distributions of their hosts. The degree of specialization on hosts varied in some parasite lineages over short periods and small geographic distances independently of the diversity of available hosts and potentially competing parasite lineages. Nonrandom spatial turnover was apparent in parasite lineages infecting one host species that was well-sampled within a single year across its range, plausibly reflecting localized adaptations of hosts and parasites. Overall, populations of avian hosts generally determine the geographic distributions of haemosporidian parasites. However, parasites are not dispersal-limited within their host distributions, and they may switch hosts readily.

  9. Passive Forensics for Region Duplication Image Forgery Based on Harris Feature Points and Local Binary Patterns

    Directory of Open Access Journals (Sweden)

    Jie Zhao

    2013-01-01

    Full Text Available Nowadays the demand for identifying the authenticity of an image is much increased since advanced image editing software packages are widely used. Region duplication forgery is one of the most common and immediate tampering attacks which are frequently used. Several methods to expose this forgery have been developed to detect and locate the tampered region, while most methods do fail when the duplicated region undergoes rotation or flipping before being pasted. In this paper, an efficient method based on Harris feature points and local binary patterns is proposed. First, the image is filtered with a pixelwise adaptive Wiener method, and then dense Harris feature points are employed in order to obtain a sufficient number of feature points with approximately uniform distribution. Feature vectors for a circle patch around each feature point are extracted using local binary pattern operators, and the similar Harris points are matched based on their representation feature vectors using the BBF algorithm. Finally, RANSAC algorithm is employed to eliminate the possible erroneous matches. Experiment results demonstrate that the proposed method can effectively detect region duplication forgery, even when an image was distorted by rotation, flipping, blurring, AWGN, JPEG compression, and their mixed operations, especially resistant to the forgery with the flat area of little visual structures.

  10. Local and Regional Authorities as Resources for Implementing Universal Design Policy in Norway.

    Science.gov (United States)

    Lund, Einar

    2016-01-01

    The municipalities and regional authorities are in general resources for achieving national goals. Their management and works are crucial to the development and implementation of Universal Design. Through several programmes, national authorities have worked for activating the local and regional levels. The results are visible. We can see a long-term national strategy to help make society accessible to everyone and prevent discrimination. Participating municipalities and regional authorities are now able to create their own policy and strategies and implement solutions. The national programs have involved interested and motivated municipalities. All the 18 counties in Norway have been involved more or less in different periods and the same with up to a third of the about good 400 municipalities.

  11. Decentralization and public expenditure: Does special local autonomy affect regional economic growth?

    Directory of Open Access Journals (Sweden)

    Martapina Anggai

    2018-04-01

    Full Text Available This study examines the relationship between public expenditure within regional autonomy policy and economic growth in West Papua and Papua provinces. We distinguish two kinds of expenditure’s decentralization – operational and capital – and also private expenditures. We use an unbalanced panel data over the period of 2007-2010 to investigate those expenditures, whether they enhance regional economic growth or not. We find that the government’s operating and private expenditures have a positive effect on local economic growth, but there is no relationship between capital expenditure’s decentralization on economic growth. The findings did not conform to a-priori efficiency expectations, which suggest needing to reform regional autonomy and fiscal decentralization policy in both provinces.

  12. Environmental impact assessment: use of literature data versus use of specific local and regional data

    International Nuclear Information System (INIS)

    Rochedo, Elaine R.R.; Wasserman, Maria Angelica

    2000-01-01

    The environmental radiological impact assessment methodology includes a large number of parameters to simulate the environmental transfer and population exposure. Local and regional data are often not available, particularly for tropical regions, which leads to the use of literature data, mostly determined at temperate climate countries. Since 1993, IRD has been developing radioecological studies aiming the determination soil-plant transfer factors, which showed the possibility of finding values up to one order of magnitude higher than those found at temperate climate countries literature. This paper compares dose results for several scenarios, using regional and literature data, assessing the relevance of using site specific data for radiological impact assessments, for both practices and intervention situations. (author)

  13. Strong influence of regional species pools on continent-wide structuring of local communities

    DEFF Research Database (Denmark)

    Lessard, Jean-Philippe; Borregaard, Michael Krabbe; Fordyce, James A.

    2012-01-01

    pool, to examine the interplay between broad-scale evolutionary and fine-scale ecological processes. Finally, a renewed interest in the influence of species source pools on communities has shown that the definition of the source pool influences interpretations of patterns of community structure. We use...... of communities along climatic gradients. We find that the average phylogenetic relatedness of species in ant communities decreases from tropical to temperate regions, but the strength of this relationship depends on the level of ecological realism in the definition of source pools. We conclude that the evolution...... of climatic niches influences the phylogenetic structure of regional source pools and that the influence of regional source pools on local community structure is strong....

  14. A robust automated left ventricle region of interest localization technique using a cardiac cine MRI atlas

    Science.gov (United States)

    Ben-Zikri, Yehuda Kfir; Linte, Cristian A.

    2016-03-01

    Region of interest detection is a precursor to many medical image processing and analysis applications, including segmentation, registration and other image manipulation techniques. The optimal region of interest is often selected manually, based on empirical knowledge and features of the image dataset. However, if inconsistently identified, the selected region of interest may greatly affect the subsequent image analysis or interpretation steps, in turn leading to incomplete assessment during computer-aided diagnosis or incomplete visualization or identification of the surgical targets, if employed in the context of pre-procedural planning or image-guided interventions. Therefore, the need for robust, accurate and computationally efficient region of interest localization techniques is prevalent in many modern computer-assisted diagnosis and therapy applications. Here we propose a fully automated, robust, a priori learning-based approach that provides reliable estimates of the left and right ventricle features from cine cardiac MR images. The proposed approach leverages the temporal frame-to-frame motion extracted across a range of short axis left ventricle slice images with small training set generated from les than 10% of the population. This approach is based on histogram of oriented gradients features weighted by local intensities to first identify an initial region of interest depicting the left and right ventricles that exhibits the greatest extent of cardiac motion. This region is correlated with the homologous region that belongs to the training dataset that best matches the test image using feature vector correlation techniques. Lastly, the optimal left ventricle region of interest of the test image is identified based on the correlation of known ground truth segmentations associated with the training dataset deemed closest to the test image. The proposed approach was tested on a population of 100 patient datasets and was validated against the ground truth

  15. Constancy despite variability: Local and regional macrofaunal diversity in intertidal seagrass beds

    Science.gov (United States)

    Boyé, Aurélien; Legendre, Pierre; Grall, Jacques; Gauthier, Olivier

    2017-12-01

    The importance of seagrass habitat for the diversity of benthic fauna has been extensively studied worldwide. Most of the information available is, however, about α diversity while little consideration has been given to β diversity. To fill the knowledge gaps regarding the variability of epifaunal and infaunal seagrass assemblages at large spatial and temporal scales, we scrutinized an extensive dataset covering five years of monitoring of eight intertidal Zostera marina meadows around Brittany (France). High species richness arose at the regional scale from the combination of high local diversity of the meadows and substantial among-meadows β diversity. Epifauna and infauna appeared as distinct self-communities as they displayed different spatial and temporal patterns and varied in their responses to local hydrological conditions. Infauna had higher total β diversity than epifauna due to a tighter link to the great variability of local environmental conditions in the region. Both exhibited substantial variations in species composition and community structure with variations of dominant species that were accompanied by extensive change in numerous rare species. The dominant epifaunal species were all grazers. Changes in species composition were induced mostly by species replacement and rarely by richness differences between meadows. Indeed, species richness remained within a narrow range for all seagrass beds, suggesting a potential carrying capacity for species richness of the meadows. Overall, all meadows contributed equally to the regional turnover of seagrass macrofauna, emphasizing high variability and complementarity among beds at the regional scale. The implications of this substantial within-seagrass variability for the functioning of benthic ecosystems at broad scale and for conservation purposes in habitat mosaics warrant further investigations but our results clearly advocate taking into account within-habitat variation when evaluating the diversity

  16. Radiotherapy is associated with significant improvement in local and regional control in Merkel cell carcinoma

    International Nuclear Information System (INIS)

    Kang, Susan H; Haydu, Lauren E; Goh, Robin Yeong Hong; Fogarty, Gerald B

    2012-01-01

    Merkel cell carcinoma (MCC) is a rare tumour of skin. This study is a retrospective audit of patients with MCC from St Vincent’s and Mater Hospital, Sydney, Australia. The aim of this study was to investigate the influence of radiotherapy (RT) on the local and regional control of MCC lesions and survival of patients with MCC. The data bases in anatomical pathology, RT and surgery. We searched for patients having a diagnosis of MCC between 1996 and 2007. Patient, tumour and treatment characteristics were collected and analysed. Univariate survival analysis of categorical variables was conducted with the Kaplan-Meier method together with the Log-Rank test for statistical significance. Continuous variables were assessed using the Cox regression method. Multivariate analysis was performed for significant univariate results. Sixty seven patients were found. Sixty two who were stage I-III and were treated with radical intent were analysed. 68% were male. The median age was 74 years. Forty-two cases (68%) were stage I or II, and 20 cases (32%) were stage III. For the subset of 42 stage I and II patients, those that had RT to their primary site had a 2-year local recurrence free survival of 89% compared with 36% for patients not receiving RT (p<0.001). The cumulative 2-year regional recurrence free survival for patients having adjuvant regional RT was 84% compared with 43% for patients not receiving this treatment (p<0.001). Immune status at initial surgery was a significant predictor for OS and MCCSS. In a multivariate analysis combining macroscopic size (mm) and immune status at initial surgery, only immune status remained a significant predictor of overall survival (HR=2.096, 95% CI: 1.002-4.385, p=0.049). RT is associated with significant improvement in local and regional control in Merkel cell carcinoma. Immunosuppression is an important factor in overall survival

  17. Salvage treatment for local or local-regional recurrence after initial breast conservation treatment with radiation for ductal carcinoma in situ

    NARCIS (Netherlands)

    Solin, Lawrence J.; Fourquet, Alain; Vicini, Frank A.; Taylor, Marie; Haffty, Bruce; Strom, Eric A.; Wai, Elaine; Pierce, Lori J.; Marks, Lawrence B.; Bartelink, Harry; Campana, Francois; McNeese, Marsha D.; Jhingran, Anuja; Olivotto, Ivo A.; Bijker, Nina; Hwang, Wei-Ting

    2005-01-01

    The present study evaluated the outcome of salvage treatment for women with local or local-regional recurrence after initial breast conservation treatment with radiation for mammographically detected ductal carcinoma in situ (DCIS; intraductal carcinoma) of the breast. The study cohort consisted of

  18. 40 CFR 109.5 - Development and implementation criteria for State, local and regional oil removal contingency plans.

    Science.gov (United States)

    2010-07-01

    ... regional oil removal contingency plans. Criteria for the development and implementation of State, local and... 40 Protection of Environment 21 2010-07-01 2010-07-01 false Development and implementation criteria for State, local and regional oil removal contingency plans. 109.5 Section 109.5 Protection of...

  19. Undergraduate Regional Migration in the UK: Perspectives on Local Markets and Trends for Gender and International Student Groups

    Science.gov (United States)

    McClelland, Robert J.; Gandy, Robert J.

    2012-01-01

    This article presents an analysis of degree course acceptances for UK undergraduate students in 2002 and 2008. It examines student mobility between the UK regions, and the trends in their movement within local markets. Data shows a growing trend for students to study within local regions, especially women. Increases in acceptances of over 10% are…

  20. 20 CFR 661.290 - Under what circumstances may States require Local Boards to take part in regional planning...

    Science.gov (United States)

    2010-04-01

    ... what circumstances may States require Local Boards to take part in regional planning activities? (a... 20 Employees' Benefits 3 2010-04-01 2010-04-01 false Under what circumstances may States require Local Boards to take part in regional planning activities? 661.290 Section 661.290 Employees' Benefits...

  1. The Perpetuation of a System of Conflicts in Darfur: Caught Between Local Violence and Regional Disorder

    Directory of Open Access Journals (Sweden)

    Amandine Gnanguênon

    2013-10-01

    Full Text Available En muchos casos en África, los conflictos locales armados y no armados, considerados por separado, interactúan hasta el punto de crear lo que puede llamarse "complejos" o "sistemas". Si bien algunos de los conceptos nos pueden ayudar a definir la dimensión regional de los conflictos locales, no nos proporcionan una mejor comprensión acerca de la superposición de varios conflictos. Tomando el ejemplo de Darfur en el periodo entre 2003 y 2011, este artículo contribuye a aclarar cómo la violencia y el desorden surgieron y se desarrollaron, tanto a nivel local como nacional y regional. El artículo propone una demostración empírica de la originalidad y la pertinencia del concepto de sistema de conflictos, con el objetivo de abrir un debate en la investigación actual sobre las definiciones de conflicto y guerra desde un prisma africano.

  2. Biomechanics of Ergometric Stress Test: regional and local effects on elastic, transitional and muscular human arteries

    Science.gov (United States)

    Valls, G.; Torrado, J.; Farro, I.; Bia, D.; Zócalo, Y.; Lluberas, S.; Craiem, D.; Armentano, Rl

    2011-09-01

    Ergometric exercise stress tests (EST) give important information about the cardiovascular (CV) response to increased demands. The expected EST-related changes in variables like blood pressure and heart rate are known, but those in the arterial biomechanics are controversial and incompletely characterized. In this context, this work aims were to characterize the regional and local arterial biomechanical behaviour in response to EST; to evaluate its temporal profile in the post-EST recovery phase; and to compare the biomechanical response of different to EST. Methods: In 16 non-trained healthy young subjects the carotid-femoral pulse wave velocity and the carotid, femoral and brachial arterial distensibility were non-invasively evaluated before (Rest) and after EST. Main results: The EST resulted in an early increase in the arterial stiffness, evidenced by both, regional and local parameters (pulse wave velocity increase and distensibility reduction). When analyzing conjunctly the different post-EST recovery stages there were quali-quantitative differences among the arterial local stiffness response to EST. The biomechanical changes could not be explained only by blood pressure variations.

  3. Biomechanics of Ergometric Stress Test: regional and local effects on elastic, transitional and muscular human arteries

    International Nuclear Information System (INIS)

    Valls, G; Torrado, J; Farro, I; Bia, D; Zocalo, Y; Lluberas, S; Armentano, RL; Craiem, D

    2011-01-01

    Ergometric exercise stress tests (EST) give important information about the cardiovascular (CV) response to increased demands. The expected EST-related changes in variables like blood pressure and heart rate are known, but those in the arterial biomechanics are controversial and incompletely characterized. In this context, this work aims were to characterize the regional and local arterial biomechanical behaviour in response to EST; to evaluate its temporal profile in the post-EST recovery phase; and to compare the biomechanical response of different to EST. Methods: In 16 non-trained healthy young subjects the carotid-femoral pulse wave velocity and the carotid, femoral and brachial arterial distensibility were non-invasively evaluated before (Rest) and after EST. Main results: The EST resulted in an early increase in the arterial stiffness, evidenced by both, regional and local parameters (pulse wave velocity increase and distensibility reduction). When analyzing conjunctly the different post-EST recovery stages there were quali-quantitative differences among the arterial local stiffness response to EST. The biomechanical changes could not be explained only by blood pressure variations.

  4. Regional and local land subsidence at the Venice coastland by TerraSAR-X PSI

    Directory of Open Access Journals (Sweden)

    L. Tosi

    2015-11-01

    Full Text Available Land subsidence occurred at the Venice coastland over the 2008–2011 period has been investigated by Persistent Scatterer Interferometry (PSI using a stack of 90 TerraSAR-X stripmap images with a 3 m resolution and a 11-day revisiting time. The regular X-band SAR acquisitions over more than three years coupled with the very-high image resolution has significantly improved the monitoring of ground displacements at regional and local scales, e.g., the entire lagoon, especially the historical palaces, the MoSE large structures under construction at the lagoon inlets to disconnect the lagoon from the Adriatic Sea during high tides, and single small structures scattered within the lagoon environments. Our results show that subsidence is characterized by a certain variability at the regional scale with superimposed important local displacements. The movements range from a gentle uplift to subsidence rates of up to 35 mm yr−1. For instance, settlements of 30–35 mm yr−1 have been detected at the three lagoon inlets in correspondence of the MoSE works, and local sinking bowls up to 10 mm yr−1 connected with the construction of new large buildings or restoration works have been measured in the Venice and Chioggia historical centers. Focusing on the city of Venice, the mean subsidence of 1.1 ± 1.0 mm yr−1 confirms the general stability of the historical center.

  5. The Ironbridge Gorge Heritage Site and its local and regional functions

    Directory of Open Access Journals (Sweden)

    Cudny Waldemar

    2017-06-01

    Full Text Available The article is devoted to the issue of heritage and its functions. Based on the existing literature, the author presents the definition of heritage, the classification of heritage resources, and its most important impacts. The aim of the article was to show the functions that may be performed by a heritage site, locally and regionally. The example used by the author is the Ironbridge Gorge Heritage Site in the United Kingdom. Most heritage functions described by other authors are confirmed in this case study. The cultural heritage of the Ironbridge Gorge creates an opportunity to undertake various local and regional activities, having first of all an educational influence on the inhabitants, school youth and tourists. We must not ignore the economicinfluences, such as financing the activity of the Ironbridge Trust (the institution administering the site, generating income for local firms providing service to tourists, or for construction companies. This income helps to preserve and conserve the tangible heritage of the Ironbridge Gorge, as well as to generate jobs in heritage management, conservation and heritage tourism. Other effects of the Ironbridge Gorge Site include a socio-cultural impact or that related to sustainable development.

  6. The Importance of Biotic vs. Abiotic Drivers of Local Plant Community Composition Along Regional Bioclimatic Gradients.

    Directory of Open Access Journals (Sweden)

    Kari Klanderud

    Full Text Available We assessed if the relative importance of biotic and abiotic factors for plant community composition differs along environmental gradients and between functional groups, and asked which implications this may have in a warmer and wetter future. The study location is a unique grid of sites spanning regional-scale temperature and precipitation gradients in boreal and alpine grasslands in southern Norway. Within each site we sampled vegetation and associated biotic and abiotic factors, and combined broad- and fine-scale ordination analyses to assess the relative explanatory power of these factors for species composition. Although the community responses to biotic and abiotic factors did not consistently change as predicted along the bioclimatic gradients, abiotic variables tended to explain a larger proportion of the variation in species composition towards colder sites, whereas biotic variables explained more towards warmer sites, supporting the stress gradient hypothesis. Significant interactions with precipitation suggest that biotic variables explained more towards wetter climates in the sub alpine and boreal sites, but more towards drier climates in the colder alpine. Thus, we predict that biotic interactions may become more important in alpine and boreal grasslands in a warmer future, although more winter precipitation may counteract this trend in oceanic alpine climates. Our results show that both local and regional scales analyses are needed to disentangle the local vegetation-environment relationships and their regional-scale drivers, and biotic interactions and precipitation must be included when predicting future species assemblages.

  7. Surface temperature and evapotranspiration: application of local scale methods to regional scales using satellite data

    International Nuclear Information System (INIS)

    Seguin, B.; Courault, D.; Guerif, M.

    1994-01-01

    Remotely sensed surface temperatures have proven useful for monitoring evapotranspiration (ET) rates and crop water use because of their direct relationship with sensible and latent energy exchange processes. Procedures for using the thermal infrared (IR) obtained with hand-held radiometers deployed at ground level are now well established and even routine for many agricultural research and management purposes. The availability of IR from meteorological satellites at scales from 1 km (NOAA-AVHRR) to 5 km (METEOSAT) permits extension of local, ground-based approaches to larger scale crop monitoring programs. Regional observations of surface minus air temperature (i.e., the stress degree day) and remote estimates of daily ET were derived from satellite data over sites in France, the Sahel, and North Africa and summarized here. Results confirm that similar approaches can be applied at local and regional scales despite differences in pixel size and heterogeneity. This article analyzes methods for obtaining these data and outlines the potential utility of satellite data for operational use at the regional scale. (author)

  8. Policy regime and policy change: Comparing the phenomenon of local government before and after regional autonomy

    Directory of Open Access Journals (Sweden)

    Kamaludin Kamaludin

    2018-04-01

    Full Text Available This research aims to evaluate the financial performance of four municipalities (Bengkulu City, Rejang Lebong Regency, South Bengkulu Regency, and North Bengkulu Regency in Bengkulu Province, Indonesia. The study also identifies the contribution of several financial variables before and after the implementation of regional autonomy. Theoretically, regional autonomy enables these four municipalities to manage their Local Own-Source Revenue (LOSR or PAD - Pendapatan Asli Daerah better because these municipalities now have to learn to manage their financial resources independently. However, the findings indicate that these four municipalities still exhibit a high financial dependency on the central government or the fiscal balance fund. Consequently, the contribution of LOSR to the total income is still low. Besides, the study finds that these four municipalities exhibit a sufficiently good efficiency ratio but a fluctuating LOSR growth ratio, especially in some municipalities before the proliferation of new municipalities. Further, the main variables of the degree of financial decentralization, local financial autonomy, efficiency, and LOSR growth do not exhibit significant differences between the pre- and post- regional autonomy implementation.

  9. A LOCAL DEVELOPMENT PROJECT IN THE FRAMEWORK OF PUBLIC POLICIES FOCUSED ON REGIONAL DEVELOPMENT STRATEGIES

    Directory of Open Access Journals (Sweden)

    George Schin

    2013-12-01

    Full Text Available This paper aims at outlining a successful implementation of a project within LEADER framework, which is a local development method which allows local actors to develop an area by using its endogenous development potential. After a brief presentation of the characteristics of regional development strategies in Romania, there were emphasized the objectives and activities encompassed in a local development plan, managed by the leaders of the local action group called ‘Vrancea County’. In order to reinforce the strengths of Vrancea County and implicitly to assure a sustainable development of this area from the South-East part of Romania, a LAG constituted through a partnership between public and private actors settled a set of priorities to be exploited by means of specific actions. The goal of this paper is to highlight these priorities, by integrating them in a project management approach. The paper concludes with specifications about how Microsoft Project software could support project management initiatives that will be developed by the LAG Vrancea County in the next period.

  10. Do mesoscale faults in a young fold belt indicate regional or local stress?

    Science.gov (United States)

    Kokado, Akihiro; Yamaji, Atsushi; Sato, Katsushi

    2017-04-01

    The result of paleostress analyses of mesoscale faults is usually thought of as evidence of a regional stress. On the other hand, the recent advancement of the trishear modeling has enabled us to predict the deformation field around fault-propagation folds without the difficulty of assuming paleo mechanical properties of rocks and sediments. We combined the analysis of observed mesoscale faults and the trishear modeling to understand the significance of regional and local stresses for the formation of mesoscale faults. To this end, we conducted the 2D trishear inverse modeling with a curved thrust fault to predict the subsurface structure and strain field of an anticline, which has a more or less horizontal axis and shows a map-scale plane strain perpendicular to the axis, in the active fold belt of Niigata region, central Japan. The anticline is thought to have been formed by fault-propagation folding under WNW-ESE regional compression. Based on the attitudes of strata and the positions of key tephra beds in Lower Pleistocene soft sediments cropping out at the surface, we obtained (1) a fault-propagation fold with the fault tip at a depth of ca. 4 km as the optimal subsurface structure, and (2) the temporal variation of deformation field during the folding. We assumed that mesoscale faults were activated along the direction of maximum shear strain on the faults to test whether the fault-slip data collected at the surface were consistent with the deformation in some stage(s) of folding. The Wallace-Bott hypothesis was used to estimate the consistence of faults with the regional stress. As a result, the folding and the regional stress explained 27 and 33 of 45 observed faults, respectively, with the 11 faults being consistent with the both. Both the folding and regional one were inconsistent with the remaining 17 faults, which could be explained by transfer faulting and/or the gravitational spreading of the growing anticline. The lesson we learnt from this work was

  11. Regional growth management policies: Toward reducing global warming at state and local levels

    International Nuclear Information System (INIS)

    Purdie, J.

    1995-01-01

    State and local governments in the United States are accepting mandates to coordinate legislated land use and growth management planning with vigorous environmental protection and resource conservation. These mandates, implemented or planned in states with populations totaling over 100 million, will directly impact growth patterns and ultimately affect the level of atmospheric gases and particulates generated within their borders. This paper addresses the issues of growth management and land use planning at the local, state and regional levels and identifies areas impacting global warming. A review of existing systems will be presented, and recommendations will be made to improve monitoring of growth management mechanisms and organizational structures with the goal of global atmospheric improvement. The issues discussed include urban sprawl, transportation, and growth patterns as managed by policies also designed to protect environments and provide for sustainable growth. Areas for improved coordination between jurisdictions to ease global warming will also be examined

  12. Disparities in the Use of Radiation Therapy in Patients With Local-Regionally Advanced Breast Cancer

    International Nuclear Information System (INIS)

    Martinez, Steve R.; Beal, Shannon H.; Chen, Steven L.; Canter, Robert J.; Khatri, Vijay P.; Chen, Allen; Bold, Richard J.

    2010-01-01

    Background: Radiation therapy (RT) is indicated for the treatment of local-regionally advanced breast cancer (BCa). Hypothesis: We hypothesized that black and Hispanic patients with local-regionally advanced BCa would receive lower rates of RT than their white counterparts. Methods: The Surveillance Epidemiology and End Results database was used to identify white, black, Hispanic, and Asian patients with invasive BCa and ≥10 metastatic lymph nodes diagnosed between 1988 and 2005. Univariate and multivariate logistic regression evaluated the relationship of race/ethnicity with use of RT. Multivariate models stratified for those undergoing mastectomy or lumpectomy. Results: Entry criteria were met by 12,653 patients. Approximately half of the patients did not receive RT. Most patients were white (72%); the remainder were Hispanic (10.4%), black (10.3%), and Asian (7.3%). On univariate analysis, Hispanics (odd ratio [OR] 0.89; 95% confidence interval [CI], 0.79-1.00) and blacks (OR 0.79; 95% CI, 0.70-0.89) were less likely to receive RT than whites. On multivariate analysis, blacks (OR 0.76; 95% CI, 0.67-0.86) and Hispanics (OR 0.80; 95% CI, 0.70-0.90) were less likely than whites to receive RT. Disparities persisted for blacks (OR 0.74; 95% CI, 0.64-0.85) and Hispanics (OR 0.77; 95% CI, 0.67-0.89) who received mastectomy, but not for those who received lumpectomy. Conclusions: Many patients with local-regionally advanced BCa do not receive RT. Blacks and Hispanics were less likely than whites to receive RT. This disparity was noted predominately in patients who received mastectomy. Future efforts at improving rates of RT are warranted. Efforts at eliminating racial/ethnic disparities should focus on black and Hispanic candidates for postmastectomy RT.

  13. From Cell to Tissue Properties-Modeling Skin Electroporation With Pore and Local Transport Region Formation.

    Science.gov (United States)

    Dermol-Cerne, Janja; Miklavcic, Damijan

    2018-02-01

    Current models of tissue electroporation either describe tissue with its bulk properties or include cell level properties, but model only a few cells of simple shapes in low-volume fractions or are in two dimensions. We constructed a three-dimensional model of realistically shaped cells in realistic volume fractions. By using a 'unit cell' model, the equivalent dielectric properties of whole tissue could be calculated. We calculated the dielectric properties of electroporated skin. We modeled electroporation of single cells by pore formation on keratinocytes and on the papillary dermis which gave dielectric properties of the electroporated epidermis and papillary dermis. During skin electroporation, local transport regions are formed in the stratum corneum. We modeled local transport regions and increase in their radii or density which affected the dielectric properties of the stratum corneum. The final model of skin electroporation accurately describes measured electric current and voltage drop on the skin during electroporation with long low-voltage pulses. The model also accurately describes voltage drop on the skin during electroporation with short high-voltage pulses. However, our results indicate that during application of short high-voltage pulses additional processes may occur which increase the electric current. Our model connects the processes occurring at the level of cell membranes (pore formation), at the level of a skin layer (formation of local transport region in the stratum corneum) with the tissue (skin layers) and even level of organs (skin). Using a similar approach, electroporation of any tissue can be modeled, if the morphology of the tissue is known.

  14. Synchronizing spatiotemporal chaos by introducing a finite flat region in the local map

    Directory of Open Access Journals (Sweden)

    J. Y. Chen

    2001-01-01

    Full Text Available An approach to synchronize spatiotemporal chaos is proposed. It is achieved by introducing a finite flat region in the local map. By using this scheme, a number of orbits in both the drive and the response subsystems are forced to pass through a fixed point in every dimension. With only an arbitrary phase space variable as drive signal, synchronization of spatiotemporal chaos can be achieved rapidly in the response subsystem. This is an advantage when compared with other synchronization methods that require a linear combination of the original phase space variables.

  15. Observations of regional and local variability in the optical properties of maritime clouds

    Energy Technology Data Exchange (ETDEWEB)

    White, A.B. [Univ. of Colorado at Boulder/National Oceanic and Atmospheric Administration, Boulder, CO (United States); Fairall, C.W. [Environmental Technology Lab., Boulder, CO (United States)

    1996-04-01

    White and Fairall (1995) calculated the optical properties of the marine boundary layer (MBL) clouds observed during the Atlantic Stratocumulus Transition Experiment (ASTEX) and compared their results with the results obtained by Fairall et al. for the MBL clouds observed during the First International Satellite Climatology Program (ISSCP) Regional Experiment (FIRE). They found a factor of two difference in the optical depth versus liquid water relationship that applies to the clouds observed in each case. In the present study, we present evidence to support this difference. We also investigate the local variability exhibited in the ASTEX optical properties using measurements of the boundary layer aerosol concentration.

  16. Context-dependent colonization dynamics: Regional reward contagion drives local compression in aquatic beetles.

    Science.gov (United States)

    Pintar, Matthew R; Resetarits, William J

    2017-09-01

    Habitat selection by colonizing organisms is an important factor in determining species abundance and community dynamics at multiple spatial scales. Many organisms select habitat patches based on intrinsic patch quality, but patches exist in complex landscapes linked by dispersal and colonization, forming metapopulations and metacommunities. Perceived patch quality can be influenced by neighbouring patches through spatial contagion, wherein perceived quality of one patch can extend beyond its borders and either increase or decrease the colonization of neighbouring patches and localities. These spatially explicit colonization dynamics can result in habitat compression, wherein more colonists occupy a patch or locality than in the absence of spatial context dependence. Previous work on contagion/compression focused primarily on the role of predators in driving colonization patterns. Our goal was to determine whether resource abundance can drive multi-scale colonization dynamics of aquatic beetles through the processes of contagion and compression in naturally colonized experimental pools. We established two levels (high/low quality) of within-patch resource abundances (leaf litter) using an experimental landscape of mesocosms, and assayed colonization by 35 species of aquatic beetles. Patches were arranged in localities (sets of two patches), which consisted of a combination of two patch-level resource levels in a 2 × 2 factorial design, allowing us to assay colonization at both locality and patch levels. We demonstrate that patterns of species abundance and richness of colonizing aquatic beetles are determined by patch quality and context-dependent processes at multiple spatial scales. Localities that consisted of at least one high-quality patch were colonized at equivalent rates that were higher than localities containing only low-quality patches, displaying regional reward contagion. In localities that consisted of one high- and one low-quality patch, reward

  17. The oil industry and his environmental impacts in the Amazon region -local study: Urucu and Jurua

    International Nuclear Information System (INIS)

    Souza Junior, A.B. de.

    1991-04-01

    The oil exploration and production, from the point of view of the main interactions with the environment, in the Amazon Region considering as reference the performance of PETROBRAS in the areas of the Urucu and Jurua rivers, in the Middle Solimoes, in the State of Amazonas are described. The paper comprises basically two sections. The first one is divided into four topics that refer to the analysis of prospecting, drilling, production and oil transportation. The second section of this work is more concerned to the analysis of the local and regional repercussions and expectations in the social and economical level, after the Urucu and Jurua areas were confirmed as another Brazilian oil province. (author)

  18. Neoliberal governance, sustainable development and local communities in the Barents Region

    Directory of Open Access Journals (Sweden)

    Monica Tennberg

    2014-04-01

    Full Text Available There are currently high hopes in the Barents Region for economic growth, higher employment and improved well-being, encouraged by developments in the energy industry, tourism and mining. The article discusses these prospects from the perspective of local communities in five locations in the region, which spans the northernmost counties of Finland, Norway, Sweden and Northwest Russia. The communities studied are remote, relatively small, multicultural, and dependent on natural resources. The salient dynamic illuminated in the research is how ideas of sustainability and neoliberal governance meet in community development. While the two governmentalities often conflict, they sometimes also complement one another, posing a paradox that raises concerns over the social aspect of sustainable development in particular. The article is based on international, multidisciplinary research drawing on interviews as well as statistical and documentary analysis.

  19. Energy Road-map 2050: Towards regional and local energy Road-maps. IMAGINE seminar 2011

    International Nuclear Information System (INIS)

    Maillot, Herve; Pidoux, Blandine

    2011-11-01

    The 2011 IMAGINE Seminar held in Brussels on 9 November 2011 united around fifty representatives from Energy Cities network member cities as well as representatives from the European Parliament and the Commission, various industrial sectors and civil society organisations. Participants were invited to share their visions of their action by 2040-2050 in a sustainable and desirable city, having achieved its energy transition. The spontaneous and inspiring discussions that followed broached the following questions: - What is and should be the role of the local level in the EU Energy Road-map? - What if European local authorities were to develop their own 'Energy 2050' Road-maps? - What local and regional policies can social and economic players use for contributing to achieving European targets? - Under what conditions is the 'low energy cities with a high quality of life for all' concept relevant? The debate helped outline a shared, global vision as a step towards European collective dynamics giving territories a major role in energy transition. At the end of the day, participants from very different backgrounds converged on the following key points: - Like European institutions, territories must develop a long-term vision, failing which they will be unable to take meaningful action, mobilise players and make the right decisions in the short-term. - The energy-territory relationship, from efficient energy use to supply policies, is a major democratic challenge. - Although a number of technologies are already available, they still have to be integrated so that citizens can satisfy their needs and become fully accountable for their energy use. - Energy strategies must help meet a number of local challenges: social and territorial cohesion, employment and economic development, environmental protection and quality of life. To do so, they need to be designed taking those they are supposed to serve, i.e. citizens, into consideration. - The interaction between local

  20. Isolated local-regional recurrence of breast cancer following mastectomy: Radiotherapeutic management

    International Nuclear Information System (INIS)

    Halverson, K.J.; Perez, C.A.; Kuske, R.R.; Garcia, D.M.; Simpson, J.R.; Fineberg, B.

    1990-01-01

    Two hundred twenty-four patients with their first, isolated local-regional recurrence of breast cancer were irradiated with curative intent. Patients who had previous chest wall or regional lymphatic irradiation were not included in the study. With a median follow-up of 46 months (range 24 to 241 months), the 5- and 10-year survival for the entire group were 43% and 26%, respectively. Overall, 57% of the patients were projected to be loco-regionally controlled at 5 years. The 5-year local-regional tumor control was best for patients with isolated chest wall recurrences (63%), intermediate for nodal recurrences (45%), and poor for concomitant chest wall and nodal recurrences (27%). In patients with solitary chest wall recurrences, large field radiotherapy encompassing the entire chest wall resulted in a 5- and 10-year freedom from chest wall re-recurrence of 75% and 63% in contrast to 36% and 18% with small field irradiation (p = 0.0001). For the group with recurrences completely excised, tumor control was adequate at all doses ranging from 4500 to 7000 cGy. For the recurrences less than 3 cm, 100% were controlled at doses greater than or equal to 6000 cGy versus 76% at lower doses. No dose response could be demonstrated for the larger lesions. The supraclavicular failure rate was 16% without elective radiotherapy versus 6% with elective radiotherapy (p = 0.0489). Prophylactic irradiation of the uninvolved chest wall decreased the subsequent re-recurrence rate (17% versus 27%), but the difference is not statistically significant (p = .32). The incidence of chest wall re-recurrence was 12% with doses greater than or equal to 5000 cGy compared to 27% with no elective radiotherapy, but again was not statistically significant (p = .20). Axillary and internal mammary failures were infrequent, regardless of prophylactic treatment

  1. Human impact on fluvial sediments: distinguishing regional and local sources of heavy metals contamination

    Science.gov (United States)

    Novakova, T.; Matys Grygar, T.; Bábek, O.; Faměra, M.; Mihaljevič, M.; Strnad, L.

    2012-04-01

    Industrial pollution can provide a useful tool to study spatiotemporal distribution of modern floodplain sediments, trace their provenance, and allow their dating. Regional contamination of southern Moravia (the south-eastern part of the Czech Republic) by heavy metals during the 20th century was determined in fluvial sediments of the Morava River by means of enrichment factors. The influence of local sources and sampling sites heterogeneity were studied in overbank fines with different lithology and facies. For this purpose, samples were obtained from hand-drilled cores from regulated channel banks, with well-defined local sources of contamination (factories in Zlín and Otrokovice) and also from near naturally inundated floodplains in two nature protected areas (at 30 km distance). The analyses were performed by X-ray fluorescence spectroscopy (ED XRF), ICP MS (EDXRF samples calibration, 206Pb/207Pb ratio), magnetic susceptibility, cation exchange capacity (CEC), and 137Cs and 210Pb activities. Enrichment factors (EF) of heavy metals (Pb, Zn, Cu and Cr) and magnetic susceptibility of overbank fines in near-naturally (near annually) inundated areas allowed us to reconstruct historical contamination by heavy metals in the entire study area independently on lithofacies. Measured lithological background values were then used for calculation of EFs in the channel sediments and in floodplain sediments deposited within narrow part of a former floodplain which is now reduced to about one quarter of its original width by flood defences. Sediments from regulated channel banks were found stratigraphically and lithologically "erratic", unreliable for quantification of regional contamination due to a high variability of sedimentary environment. On the other hand, these sediments are very sensitive to the nearby local sources of heavy metals. For a practical work one must first choose whether large scale, i.e. a really averaged regional contamination should be reconstructed

  2. Concurrent chemoradiotherapy with gemcitabine plus regional hyperthermia for locally advanced pancreatic carcinoma. Initial experience

    International Nuclear Information System (INIS)

    Ohguri, Takayuki; Imada, Hajime; Yahara, Katsuya; Morioka, Tomoaki; Nakano, Keita; Korogi, Yukunori; Narisada, Hiroyuki

    2008-01-01

    The aim of this study was to evaluate the efficacy and toxicity of concurrent chemoradiotherapy (CRT) with gemcitabine plus regional hyperthermia (HT) for locally advanced pancreatic carcinoma (LAPC). A total of 29 patients with LAPC treated with concurrent CRT using gemcitabine were retrospectively analyzed. Radiotherapy was administered with a median total dose of 61.2 Gy. Of the 29 patients, 20 (69%) also underwent regional HT during CRT (CRHT group). The remaining 9 patients did not receive regional HT (CRT group) because of a common bile duct stent placement, patient refusal, older age, or obesity. The efficacy and toxicity of the treatments and the predictors of good outcome were evaluated. The median disease progression-free and overall survival times were significantly better for the CRHT group than for the CRT group (8.8 vs. 4.9 months, P=0.02, and 18.6 vs. 9.6 months, P=0.01), respectively. Grade 3-4 hematological toxicities for the CRHT group were detected in eight patients (40%) and grade 3 nonhematologic toxicity in one (diarrhea). Concurrent CRT using gemcitabine with regional HT may be a feasible and promising regimen for LAPC, and the results justified further evaluation in a large number of patients to confirm its definite benefit. (author)

  3. Local and regional anthropogenic influence on PM 2.5 elements in Hong Kong

    Science.gov (United States)

    Hagler, G. S. W.; Bergin, M. H.; Salmon, L. G.; Yu, J. Z.; Wan, E. C. H.; Zheng, M.; Zeng, L. M.; Kiang, C. S.; Zhang, Y. H.; Schauer, J. J.

    Hong Kong's persistent unhealthy level of fine particulate matter is a current public health challenge, complicated by the city being located in the rapidly industrializing Pearl River Delta Region of China. While the sources of the region's fine particulate matter (PM 2.5) are still not well understood, this study provides new source information through ground measurements and statistical analysis of 24 elements associated with particulate matter collected on filters. Field measurements took place over 4 months (October 2002, December 2002, March 2003, and June 2003) at seven sites throughout the Pearl River Delta, with three sites located in Hong Kong and four sites in the neighboring province, Guangdong. The 4-month average element concentrations show significant variation throughout the region, with higher levels of nearly every species seen among the northern Guangdong sites in comparison to Hong Kong. The high correlation (Pearson r>0.8) and similar magnitudes of 11 species (Al, Si, S, K, Ca, Mn, Fe, Zn, Br, Rb, and Pb) at three contrasting sites in Hong Kong indicate that sources external to Hong Kong dominate the regional levels of these elements. Further correlative analysis compared Hong Kong against potential source areas in Guangdong Province (Shenzhen, Zhongshan, and Guangzhou). Moderate correlation of sulfur for all pairings of Hong Kong sites with three Guangdong sites in developed areas (average Pearson r of 0.52-0.94) supports the importance of long-distance transport impacting the region as a whole, although local sources also clearly impact observed concentrations. Varying correlative characteristics for zinc when Hong Kong sites are paired with Shenzhen (average r=0.86), Guangzhou (average r=-0.65) and Zhongshan (average r=0.45) points to a source area located south of Guangzhou and locally impacting Zhongshan. The concentration distribution and correlative characteristics of bromide point to sources located within the Pearl River Delta, but the

  4. On the local and regional influence on ground-level ozone concentrations in Hong Kong

    International Nuclear Information System (INIS)

    So, K.L.; Wang, T.

    2003-01-01

    It is imperative to consider regional scale emissions and dynamic transport in managing ozone pollution in Hong Kong. - Hong Kong is a densely populated city situated in the fast developing Pearl River Delta of southern China. In this study, the recent data on ozone (O 3 ) and related air pollutants obtained at three sites in Hong Kong are analyzed to show the variations of O 3 in urban, sub-urban and rural areas and the possible regional influences. Highest monthly averaged O 3 was found at a northeastern rural site and lowest O 3 level was observed at an urban site. The levels of NO x , CO, SO 2 and PM 10 showed a different spatial pattern with the highest level in the urban site and lowest at the rural site. Analysis of chemical species ratios such as SO 2 /NO x and CO/NO x indicated that the sites were under the influences of local and regional emissions to varying extents reflecting the characteristics of emission sources surround the respective sites. Seasonal pattern of O 3 is examined. Low O 3 level was found in summer and elevated levels occurred in autumn and spring. The latter appears different from the previous result obtained in 1996 indicating a single maximum occurring in autumn. Principal component analysis was used to further elucidate the relationships of air pollutants at each site. As expected, the O 3 variation in the northeastern rural area was largely determined by regional chemical and transport processes, while the O 3 variability at the southwestern suburban and urban sites were more influenced by local emissions. Despite the large difference in O 3 levels across the sites, total potential ozone (O 3 +NO 2 ) showed little variability. Cases of high O 3 episodes were presented and elevated O 3 levels were formed under the influence of tropical cyclone bringing in conditions of intense sunlight, high temperature and light winds. Elevated O 3 levels were also found to correlate with enhanced ratio of SO 2 to NO x , suggesting influence of

  5. New Local, National and Regional Cereal Price Indices for Improved Identification of Food Insecurity

    Science.gov (United States)

    Brown, Molly E.; Tondel, Fabien; Thorne, Jennifer A.; Essam, Timothy; Mann, Bristol F.; Stabler, Blake; Eilerts, Gary

    2011-01-01

    Large price increases over a short time period can be indicative of a deteriorating food security situation. Food price indices developed by the United Nations Food and Agriculture Organization (FAO) are used to monitor food price trends at a global level, but largely reflect supply and demand conditions in export markets. However, reporting by the United States Agency for International Development (USAID)'s Famine Early Warning Systems Network (FEWS NET) indicates that staple cereal prices in many markets of the developing world, especially in surplus-producing areas, often have a delayed and variable response to international export market price trends. Here we present new price indices compiled for improved food security monitoring and assessment, and specifically for monitoring conditions of food access across diverse food insecure regions. We found that cereal price indices constructed using market prices within a food insecure region showed significant differences from the international cereals price, and had a variable price dispersion across markets within each marketshed. Using satellite-derived remote sensing information that estimates local production and the FAO Cereals Index as predictors, we were able to forecast movements of the local or national price indices in the remote, arid and semi-arid countries of the 38 countries examined. This work supports the need for improved decision-making about targeted aid and humanitarian relief, by providing earlier early warning of food security crises.

  6. Regional estimation of geomagnetically induced currents based on the local magnetic or electric field

    Directory of Open Access Journals (Sweden)

    Viljanen Ari

    2015-01-01

    Full Text Available Previous studies have demonstrated a close relationship between the time derivative of the horizontal geomagnetic field vector (dH/dt and geomagnetically induced currents (GIC at a nearby location in a power grid. Similarly, a high correlation exists between GIC and the local horizontal geoelectric field (E, typically modelled from a measured magnetic field. Considering GIC forecasting, it is not feasible to assume that detailed prediction of time series will be possible. Instead, other measures summarising the activity level over a given period are preferable. In this paper, we consider the 30-min maximum of dH/dt or E as a local activity indicator (|dH/dt|30 or |E|30. Concerning GIC, we use the sum of currents through the neutral leads at substations and apply its 30-min maximum as a regional activity measure (GIC30. We show that |dH/dt|30 at a single point yields a proxy for GIC activity in a larger region. A practical consequence is that if |dH/dt|30 can be predicted at some point then it is also possible to assess the expected GIC level in the surrounding area. As is also demonstrated, |E|30 and GIC30 depend linearly on |dH/dt|30, so there is no saturation with increasing geomagnetic activity contrary to often used activity indices.

  7. Metropolization Process for enhancing local and regional planning : an experience of cirebon metropolitan, West Java

    Science.gov (United States)

    Supriyadi Rustidja, E.

    2018-03-01

    Metropolitan develops in line with resource utilization, investment, and transactions of regional activities. Metropolization of an area gives emerge urban economy that changes the situation, form, and pattern of urban space interactions. On the other hand, metropolism concerns the strategy of changing variation of urban space, so that metropolitan invasion not only form of urban space but also the process of interaction among stakeholders in developing metropolitan area. Based on participatory research, this article explores metropolitan invasion process for enhancing local and regional planning, both indigenous and intrusive cataclysmic. The study find that the primeval, rural, and urban as elemental environment must be considered in developing metropolitan, not merely form the structure and pattern of urban space. The metropolization process also requires the strategic of rural urban linkage, context setting and local assessment, strategic community investment, and interculturalist approach. The other findings of the study show that metropolization in Cirebon Metropolitan, West Java emphasizing on promotion of competitiveness strategy, value chain urban activities, and networking of urban areas. Cirebon Metropolitan must promote the realization of growth centers and connect the interregional activities of metropolitan area for providing sustainable economic growth.

  8. Local and regional energy companies offering energy services: Key activities and implications for the business model

    International Nuclear Information System (INIS)

    Kindström, Daniel; Ottosson, Mikael

    2016-01-01

    Highlights: • Many companies providing energy services are experiencing difficulties. • This research identifies key activities for the provision of energy services. • Findings are aggregated to the business-model level providing managerial insights. • This research identifies two different business model innovation paths. • Energy companies may need to renew parts of, or the entire, business model. - Abstract: Energy services play a key role in increasing energy efficiency in the industry. The key actors in these services are the local and regional energy companies that are increasingly implementing energy services as part of their market offering and developing service portfolios. Although expectations for energy services have been high, progress has so far been limited, and many companies offering energy services, including energy companies, are experiencing difficulties in implementing energy services and providing them to the market. Overall, this research examines what is needed for local and regional energy companies to successfully implement energy services (and consequently provide them to the market). In doing this, a two-stage process is used: first, we identify key activities for the successful implementation of energy services, and second, we aggregate the findings to the business model level. This research demonstrates that to succeed in implementing energy services, an energy company may need to renew parts or all of its existing product-based business model, formulate a new business model, or develop coexisting multiple business models. By discussing two distinct business model innovation processes, this research demonstrates that there can be different paths to success.

  9. The Development of Regional Dialect Locality Judgments and Language Attitudes Across the Life Span.

    Science.gov (United States)

    McCullough, Elizabeth A; Clopper, Cynthia G; Wagner, Laura

    2017-10-20

    The development of language attitudes and perception of talker regional background was investigated across the life span (N = 240, age range = 4-75 years). Participants rated 12 talkers on dimensions of geographic locality, status, and solidarity. Children could classify some dialects by locality by age 6-7 years and showed adult-like patterns by age 8 years. Children showed adult-like status ratings for some dialects by age 4-5 years but were not fully adult-like until age 12 years. Solidarity ratings were more variable and did not exhibit a clear developmental trajectory, although some adult-like patterns were in place by age 6-7 years. Locality ratings were a significant but modest predictor of attitude ratings, suggesting that geographic knowledge is one contributor to language attitudes throughout development. © 2017 The Authors. Child Development © 2017 Society for Research in Child Development, Inc.

  10. On the Topological Changes of Local Hurst Exponent in Polar Regions

    Science.gov (United States)

    Consolini, G.; De Michelis, P.

    2014-12-01

    Geomagnetic activity during magnetic substorms and storms is related to the dinamical and topological changes of the current systems flowing in the Earth's magnetosphere-ionosphere. This is particularly true in the case of polar regions where the enhancement of auroral electrojet current system is responsible for the observed geomagnetic perturbations. Here, using the DMA-technique we evaluate the local Hurst exponent (H"older exponent) for a set of 46 geomagnetic observatories, widely distributed in the northern hemisphere, during one of the most famous and strong geomagnetic storm, the Bastille event, and reconstruct a sequence of polar maps showing the dinamical changes of the topology of the local Hurst exponent with the geomagnetic activity level. The topological evolution of local Hurst exponent maps is discussed in relation to the dinamical changes of the current systems flowing in the polar ionosphere. G. Consolini has received funding from the European Community's Seventh Framework Programme (FP7/2007-2013) under Grant agreement no. 313038/STORM for this research.

  11. An analysis of the 'costs and effectiveness' of post-mastectomy local-regional radiation therapy

    International Nuclear Information System (INIS)

    Marks, L.B.; Prosnitz, L.R.; Hardenbergh, P.H.; Winer, E.T.

    1997-01-01

    Purpose: To estimate the 'cost/effectiveness' ratio for post-mastectomy local-regional radiation therapy (LR-XRT) for patients with breast cancer. As the risk of local-regional recurrence (LRR) is related to the number of positive axillary lymph nodes, the cost/effectiveness ratio of LR-XRT was assessed for a variable number of positive axillary nodes. For overall survival (OS), the cost per additional life-year is estimated as a function of follow-up duration. Methods/Assumptions: Literature data indicate that the risk of LRR is related to the number of positive axillary nodes (e.g. Fowble, Kuske). For example, the LRR rate is ∼10% for patients with negative nodes, increasing to ∼40% for patients with ≥4 positive nodes. Such data are used to linearly relate the number of positive nodes with the risk of LRR. Additional assumptions include: RT reduces the risk of LRR by 67%; local recurrences are treated with exision/biopsy, LR-XRT and systemic chemotherapy; half of the local recurrences are controlled locally and half will require additional salvage treatment with surgery or chemotherapy. The 5, 10 and 15 yr improvements in OS provided by LR-XRT are estimated to be 3, 7, and 10%, respectively, based on the literature (Overgaard, Ragaz, Klefstrom, Rutqvist). For each year following LR-XRT, the accrued life-years gained are estimated from the published survival curves. Professional and technical charges are used as a surrogate for costs, as follows (in thousands): LR-XRT-15; evaluation of recurrence-2; biopsy plus pathology-1; resection plus pathology-7, chemotherapy-10. Results: The cost per LRR prevented with the addition of routine post-mastectomy LR-XRT is shown, as a function of the number of positive axillary nodes. The cost per additional life-year gained with LR-XRT, as a function of follow-up duration, is shown. With increasing follow-up, the cost per life-year gained decreases as the additional life-years accrue. Conclusions: The cost per LRR

  12. First status report on regional and local ground-water flow modeling for Richton Dome, Mississippi

    International Nuclear Information System (INIS)

    Andrews, R.W.; Metcalfe, D.E.

    1984-03-01

    Regional and local ground-water flow within the principal hydrogeologic units in the vicinity of Richton Dome is evaluated by developing conceptual models of the flow regime within these units at three different scales and testing these models using a three-dimensional, finite-difference flow code. Semiquantitative sensitivity analysis is conducted to define the system response to changes in the conceptual model, particularly the hydrologic properties. The effects of salinity on the flow field are evaluated at the refined and local scales. Adjoint sensitivity analysis is applied to the conceptualized flow regime in the Wilcox aquifer. All steps leading to the final results and conclusions are incorporated in this report. The available data utilized in this study is summarized. The specific conceptual models, defining the areal and vertical averaging of lithologic units, aquifer properties, fluid properties, and hydrologic boundary conditions, are described in detail. The results are delineated by the simulated potentiometric surfaces and tables summarizing areal and vertical boundary fluxes, Darcy velocities at specific points, and ground-water travel paths. These results are presented at regional, refined, and local (near-dome) scales. The reported work is the first stage of an ongoing evaluation of the Richton Dome as a potential repository for high-level radioactive wastes. The results and conclusions should thus be considered preliminary and subject to modification with the collection of additional data. However, this report does provide a useful basis for describing the sensitivity and, to a lesser extent, the uncertainty of the present conceptualization of ground-water flow in the vicinity of Richton Dome. 25 references, 69 figures, 15 tables

  13. Monsoon rainfall behaviour in recent times on local/regional scale in India

    International Nuclear Information System (INIS)

    Singh, Surender; Rao, V.U.M.; Singh, Diwan

    2002-08-01

    An attempt has been made here to investigate the local/regional monsoon rainfall behaviour in the meteorological sub-division no. 13 comprising the areas of Haryana, Delhi and Chandigarh in India. The monthly monsoon rainfall data of 30 years (1970-99) of different locations in the region were used for the investigation. All locations except Delhi received more rainfall in monsoon season during the decade (1990-99) showing general increasing trend in the rainfall behaviour in recent times. The mean monsoon rainfall at various locations ranged between 324.8 mm at Sirsa and 974.9 mm at Chandigarh. The major amount of monsoon rainfall occurred during the month of July and August in the entire region. Monthly mean rainfall ranged between 37.5 to 144.9 mm (June), 130.6 to 298.2 mm (July), 92.6 to 313.6 mm (August) and 44.0 to 149.4mm (September) at different locations. All the locations in the region exhibited overall increasing trend in monsoon rainfall over the period under study. All locations in the region received their lowest monsoon rainfall in the year 1987 which was a drought year and the season's rainfall ranged between 56.1 mm (Sirsa) and 290.0 mm (Delhi) during this year. Many of the locations observed clusters of fluctuations in their respective monsoon rainfall. The statistical summaries of historical data series (1970-99) gave rainfall information on various time scale. Such information acquires value through its influence on the decision making of the ultimate users. (author)

  14. Attentional Performance is Correlated with the Local Regional Efficiency of Intrinsic Brain Networks

    Directory of Open Access Journals (Sweden)

    Junhai eXu

    2015-07-01

    Full Text Available Attention is a crucial brain function for human beings. Using neuropsychological paradigms and task-based functional brain imaging, previous studies have indicated that widely distributed brain regions are engaged in three distinct attention subsystems: alerting, orienting and executive control (EC. Here, we explored the potential contribution of spontaneous brain activity to attention by examining whether resting-state activity could account for individual differences of the attentional performance in normal individuals. The resting-state functional images and behavioral data from attention network test (ANT task were collected in 59 healthy subjects. Graph analysis was conducted to obtain the characteristics of functional brain networks and linear regression analyses were used to explore their relationships with behavioral performances of the three attentional components. We found that there was no significant relationship between the attentional performance and the global measures, while the attentional performance was associated with specific local regional efficiency. These regions related to the scores of alerting, orienting and EC largely overlapped with the regions activated in previous task-related functional imaging studies, and were consistent with the intrinsic dorsal and ventral attention networks (DAN/VAN. In addition, the strong associations between the attentional performance and specific regional efficiency suggested that there was a possible relationship between the DAN/VAN and task performances in the ANT. We concluded that the intrinsic activity of the human brain could reflect the processing efficiency of the attention system. Our findings revealed a robust evidence for the functional significance of the efficiently organized intrinsic brain network for highly productive cognitions and the hypothesized role of the DAN/ VAN at rest.

  15. Local and regional minimum 1D models for earthquake location and data quality assessment in complex tectonic regions: application to Switzerland

    International Nuclear Information System (INIS)

    Husen, S.; Clinton, J. F.; Kissling, E.

    2011-01-01

    One-dimensional (1D) velocity models are still widely used for computing earthquake locations at seismological centers or in regions where three-dimensional (3D) velocity models are not available due to the lack of data of sufficiently high quality. The concept of the minimum 1D model with appropriate station corrections provides a framework to compute initial hypocenter locations and seismic velocities for local earthquake tomography. Since a minimum 1D model represents a solution to the coupled hypocenter-velocity problem it also represents a suitable velocity model for earthquake location and data quality assessment, such as evaluating the consistency in assigning pre-defined weighting classes and average picking error. Nevertheless, the use of a simple 1D velocity structure in combination with station delays raises the question of how appropriate the minimum 1D model concept is when applied to complex tectonic regions with significant three-dimensional (3D) variations in seismic velocities. In this study we compute one regional minimum 1D model and three local minimum 1D models for selected subregions of the Swiss Alpine region, which exhibits a strongly varying Moho topography. We compare the regional and local minimum 1D models in terms of earthquake locations and data quality assessment to measure their performance. Our results show that the local minimum 1D models provide more realistic hypocenter locations and better data fits than a single model for the Alpine region. We attribute this to the fact that in a local minimum 1D model local and regional effects of the velocity structure can be better separated. Consequently, in tectonically complex regions, minimum 1D models should be computed in sub-regions defined by similar structure, if they are used for earthquake location and data quality assessment. (authors)

  16. Local and regional minimum 1D models for earthquake location and data quality assessment in complex tectonic regions: application to Switzerland

    Energy Technology Data Exchange (ETDEWEB)

    Husen, S.; Clinton, J. F. [Swiss Seismological Service, ETH Zuerich, Zuerich (Switzerland); Kissling, E. [Institute of Geophysics, ETH Zuerich, Zuerich (Switzerland)

    2011-10-15

    One-dimensional (1D) velocity models are still widely used for computing earthquake locations at seismological centers or in regions where three-dimensional (3D) velocity models are not available due to the lack of data of sufficiently high quality. The concept of the minimum 1D model with appropriate station corrections provides a framework to compute initial hypocenter locations and seismic velocities for local earthquake tomography. Since a minimum 1D model represents a solution to the coupled hypocenter-velocity problem it also represents a suitable velocity model for earthquake location and data quality assessment, such as evaluating the consistency in assigning pre-defined weighting classes and average picking error. Nevertheless, the use of a simple 1D velocity structure in combination with station delays raises the question of how appropriate the minimum 1D model concept is when applied to complex tectonic regions with significant three-dimensional (3D) variations in seismic velocities. In this study we compute one regional minimum 1D model and three local minimum 1D models for selected subregions of the Swiss Alpine region, which exhibits a strongly varying Moho topography. We compare the regional and local minimum 1D models in terms of earthquake locations and data quality assessment to measure their performance. Our results show that the local minimum 1D models provide more realistic hypocenter locations and better data fits than a single model for the Alpine region. We attribute this to the fact that in a local minimum 1D model local and regional effects of the velocity structure can be better separated. Consequently, in tectonically complex regions, minimum 1D models should be computed in sub-regions defined by similar structure, if they are used for earthquake location and data quality assessment. (authors)

  17. SUPPORTS FOR LOCAL BREEDS IN THE EUROPEAN REGION – AN OVERVIEW

    Directory of Open Access Journals (Sweden)

    Danijela Bojkovski

    2015-09-01

    Full Text Available This study analysed the incentives for conservation of local breeds in 35 European countries, with the particular reference to the situation in Slovenia. In order to collect all necessary data in different countries, detailed questionnaire was developed and sent out to National coordinators for Animal Genetic Resources in the European Region. Data were edited and analysed using MS Excel program where basic descriptive statistics was performed to show differences among countries in incentive payments. Incentives for local breeds in Slovenia were paid from the Agri-environmental payments. The amount of payment for one livestock unit was 89.38 € per year. Subsidies for adult cattle and horses of local breeds were therefore 89.38 € per animal, while for pigs there were 44.69 € per animal and for sheep and goats 13.41 € per animal. Comparing data from different countries, the highest subsides were received for cattle ranging from 45 € to 520 € for bulls. From all 35 countries, 16 countries have subsidies for horses. Despite two breeds of sheep and one breed of goat in Slovenia highly endangered, the level of subsides for sheep and goats for local breeds included in the environmental payments were equal i.e., 13.41 € per animal. Compared to 21 countries reported the financial support for sheep, only two countries had lower support than in Slovenia. The EC Regulations can explain differences in payments where the Member States are free when determining the payments level. Another reason could be since out of 35 countries, eleven are not EU members. National coordinators from all countries agreed that financial support per head is very important tool for breed conservation and such a practice should be continued. However, the current level of support does not compensate loss of income due to lower productivity.

  18. Development of a localized probabilistic sensitivity method to determine random variable regional importance

    International Nuclear Information System (INIS)

    Millwater, Harry; Singh, Gulshan; Cortina, Miguel

    2012-01-01

    There are many methods to identify the important variable out of a set of random variables, i.e., “inter-variable” importance; however, to date there are no comparable methods to identify the “region” of importance within a random variable, i.e., “intra-variable” importance. Knowledge of the critical region of an input random variable (tail, near-tail, and central region) can provide valuable information towards characterizing, understanding, and improving a model through additional modeling or testing. As a result, an intra-variable probabilistic sensitivity method was developed and demonstrated for independent random variables that computes the partial derivative of a probabilistic response with respect to a localized perturbation in the CDF values of each random variable. These sensitivities are then normalized in absolute value with respect to the largest sensitivity within a distribution to indicate the region of importance. The methodology is implemented using the Score Function kernel-based method such that existing samples can be used to compute sensitivities for negligible cost. Numerical examples demonstrate the accuracy of the method through comparisons with finite difference and numerical integration quadrature estimates. - Highlights: ► Probabilistic sensitivity methodology. ► Determines the “region” of importance within random variables such as left tail, near tail, center, right tail, etc. ► Uses the Score Function approach to reuse the samples, hence, negligible cost. ► No restrictions on the random variable types or limit states.

  19. STUDY ON PROJECTS CONTRACTED BY ROP - AXIS 2 PRIORITY - IMPROVING REGIONAL TRANSPORT INFRASTRUCTURE AND LOCAL

    Directory of Open Access Journals (Sweden)

    Ceausescu Aurelian Ionut

    2012-03-01

    Full Text Available This axis priority is to increase the main purpose of accessibility regions, the population mobility, goods and services to stimulate sustainable economic. Investment in transport infrastructure to facilitate mobility of people and goods, reducing the costs of transport of goods and passengers, improving access to the regional markets, increase the efficiency of economic activities, energy saving and time, creating conditions for expanding trade and implicitly productive investment. Developing transport networks will facilitate the cooperation interregional and will contribute significantly to increase competitiveness of enterprises/firms and the labour mobility, and, therefore, a development faster to Romania on the whole, but also of each region. The development of urban transport network will take into account the existing structure of public transportation to ensure where possible, improve the infrastructure of roads, which will contribute to use in a more efficient way of public transportation. Rehabilitation and upgrading urban streets, and construction, rehabilitation and upgrading of roads to his belt (the status of county Road will contribute to urban improve traffic, cut on the time of transport, road and face elimination in their localities crossing safely.

  20. The discrete and localized nature of the variable emission from active regions

    Science.gov (United States)

    Arndt, Martina Belz; Habbal, Shadia Rifai; Karovska, Margarita

    1994-01-01

    Using data from the Extreme Ultraviolet (EUV) Spectroheliometer on Skylab, we study the empirical characteristics of the variable emission in active regions. These simultaneous multi-wavelength observations clearly confirm that active regions consist of a complex of loops at different temperatures. The variable emission from this complex has very well-defined properties that can be quantitatively summarized as follows: (1) It is localized predominantly around the footpoints where it occurs at discrete locations. (2) The strongest variability does not necessarily coincide with the most intense emission. (3) The fraction of the area of the footpoints, (delta n)/N, that exhibits variable emission, varies by +/- 15% as a function of time, at any of the wavelengths measured. It also varies very little from footpoint to footpoint. (4) This fractional variation is temperature dependent with a maximum around 10(exp 5) K. (5) The ratio of the intensity of the variable to the average background emission, (delta I)/(bar-I), also changes with temperature. In addition, we find that these distinctive characteristics persist even when flares occur within the active region.

  1. Dependence of hydropower energy generation on forests in the Amazon Basin at local and regional scales.

    Science.gov (United States)

    Stickler, Claudia M; Coe, Michael T; Costa, Marcos H; Nepstad, Daniel C; McGrath, David G; Dias, Livia C P; Rodrigues, Hermann O; Soares-Filho, Britaldo S

    2013-06-04

    Tropical rainforest regions have large hydropower generation potential that figures prominently in many nations' energy growth strategies. Feasibility studies of hydropower plants typically ignore the effect of future deforestation or assume that deforestation will have a positive effect on river discharge and energy generation resulting from declines in evapotranspiration (ET) associated with forest conversion. Forest loss can also reduce river discharge, however, by inhibiting rainfall. We used land use, hydrological, and climate models to examine the local "direct" effects (through changes in ET within the watershed) and the potential regional "indirect" effects (through changes in rainfall) of deforestation on river discharge and energy generation potential for the Belo Monte energy complex, one of the world's largest hydropower plants that is currently under construction on the Xingu River in the eastern Amazon. In the absence of indirect effects of deforestation, simulated deforestation of 20% and 40% within the Xingu River basin increased discharge by 4-8% and 10-12%, with similar increases in energy generation. When indirect effects were considered, deforestation of the Amazon region inhibited rainfall within the Xingu Basin, counterbalancing declines in ET and decreasing discharge by 6-36%. Under business-as-usual projections of forest loss for 2050 (40%), simulated power generation declined to only 25% of maximum plant output and 60% of the industry's own projections. Like other energy sources, hydropower plants present large social and environmental costs. Their reliability as energy sources, however, must take into account their dependence on forests.

  2. Low-complexity atlas-based prostate segmentation by combining global, regional, and local metrics

    Energy Technology Data Exchange (ETDEWEB)

    Xie, Qiuliang; Ruan, Dan, E-mail: druan@mednet.ucla.edu [The Department of Radiation Oncology, University of California Los Angeles, California 90095 (United States)

    2014-04-15

    Purpose: To improve the efficiency of atlas-based segmentation without compromising accuracy, and to demonstrate the validity of the proposed method on MRI-based prostate segmentation application. Methods: Accurate and efficient automatic structure segmentation is an important task in medical image processing. Atlas-based methods, as the state-of-the-art, provide good segmentation at the cost of a large number of computationally intensive nonrigid registrations, for anatomical sites/structures that are subject to deformation. In this study, the authors propose to utilize a combination of global, regional, and local metrics to improve the accuracy yet significantly reduce the number of required nonrigid registrations. The authors first perform an affine registration to minimize the global mean squared error (gMSE) to coarsely align each atlas image to the target. Subsequently, atarget-specific regional MSE (rMSE), demonstrated to be a good surrogate for dice similarity coefficient (DSC), is used to select a relevant subset from the training atlas. Only within this subset are nonrigid registrations performed between the training images and the target image, to minimize a weighted combination of gMSE and rMSE. Finally, structure labels are propagated from the selected training samples to the target via the estimated deformation fields, and label fusion is performed based on a weighted combination of rMSE and local MSE (lMSE) discrepancy, with proper total-variation-based spatial regularization. Results: The proposed method was applied to a public database of 30 prostate MR images with expert-segmented structures. The authors’ method, utilizing only eight nonrigid registrations, achieved a performance with a median/mean DSC of over 0.87/0.86, outperforming the state-of-the-art full-fledged atlas-based segmentation approach of which the median/mean DSC was 0.84/0.82 when applying to their data set. Conclusions: The proposed method requires a fixed number of nonrigid

  3. Major Chromosomal Breakpoint Intervals in Breast Cancer Co-Localize with Differentially Methylated Regions

    Energy Technology Data Exchange (ETDEWEB)

    Eric Tang, Man-Hung [Cold Spring Harbor Laboratory, Cold Spring Harbor, NY (United States); Department of Oncology, Clinical Sciences, Lund University, Lund (Sweden); Varadan, Vinay; Kamalakaran, Sitharthan [Philips Research North America, Briarcliff Manor, NY (United States); Zhang, Michael Q. [Cold Spring Harbor Laboratory, Cold Spring Harbor, NY (United States); The University of Texas at Dallas, Richardson, TX (United States); Tsinghua University, Beijing (China); Dimitrova, Nevenka, E-mail: nevenka.dimitrova@philips.com [Philips Research North America, Briarcliff Manor, NY (United States); Hicks, James, E-mail: hicks@cshl.edu [Cold Spring Harbor Laboratory, Cold Spring Harbor, NY (United States)

    2012-12-27

    Solid tumors exhibit chromosomal rearrangements resulting in gain or loss of multiple chromosomal loci (copy number variation, or CNV), and translocations that occasionally result in the creation of novel chimeric genes. In the case of breast cancer, although most individual tumors each have unique CNV landscape, the breakpoints, as measured over large datasets, appear to be non-randomly distributed in the genome. Breakpoints show a significant regional concentration at genomic loci spanning perhaps several megabases. The proximal cause of these breakpoint concentrations is a subject of speculation, but is, as yet, largely unknown. To shed light on this issue, we have performed a bio-statistical analysis on our previously published data for a set of 119 breast tumors and normal controls (Wiedswang et al., 2003), where each sample has both high-resolution CNV and methylation data. The method examined the distribution of closeness of breakpoint regions with differentially methylated regions (DMR), coupled with additional genomic parameters, such as repeat elements and designated “fragile sites” in the reference genome. Through this analysis, we have identified a set of 93 regional loci called breakpoint enriched DMR (BEDMRs) characterized by altered DNA methylation in cancer compared to normal cells that are associated with frequent breakpoint concentrations within a distance of 1 Mb. BEDMR loci are further associated with local hypomethylation (66%), concentrations of the Alu SINE repeats within 3 Mb (35% of the cases), and tend to occur near a number of cancer related genes such as the protocadherins, AKT1, DUB3, GAB2. Furthermore, BEDMRs seem to deregulate members of the histone gene family and chromatin remodeling factors, e.g., JMJD1B, which might affect the chromatin structure and disrupt coordinate signaling and repair. From this analysis we propose that preference for chromosomal breakpoints is related to genome structure coupled with alterations in DNA

  4. Comparison of Sedation With Local Anesthesia and Regional Anesthesia in Transurethral Resection of Prostate (TURP

    Directory of Open Access Journals (Sweden)

    H Aghamohammadi

    2008-12-01

    Full Text Available ABSTRACT: Introduction & Objective: Transurethral Resection of Prostate (TURP is usually performed under regional or general anesthesia. An alternative to conventional anesthesia is performing of TURP under local anesthetic infiltration with sedation. The aim of this study was to evaluate the efficacy and complication of sedoanalgesia in TURP. Material & Methods: In a prospective clinical trial from September 2006 to December 2007, 60 patients (30 in each group with prostate hypertrophy, candidate for TURP, were randomly assigned into two groups. In the first group, standard spinal anesthesia was done. In the second group, five minutes before the operation, 25 mgs of diazepam plus 25-50 mgs of pethedine was intravenously administered followed by injection of 10 ml lidocaine 2% gel in the urethra and the skin in the suprapubic area was anesthetized with 2 ml of 1% lidocaine. Using a 22 gauge nephrostomy needle, the suprapubic skin was punctured and the needle was directed toward prostate apex and 10-20ml of 1% lidocaine was injected at the serosal aspect of the rectal wall. For dorsal nerve block, 5-10ml of 1% lidocaine was injected at penopubic junction, and then a standard TURP was performed. Patients were switched to another anesthetic technique if the selected technique failed. Severity of pain was assessed by visual analogue scale. Results: The average prostate size was 25 grs (range10-50grs in the local anesthetic group (group 1 and 27.5 grs (range 10-50 grs in the spinal group (group2. In the local anesthetic group, 82.3% had no or mild pain while moderate to severe pain was reported in 16, 7% of the patients. In the group with spinal anesthesia, these were 93.1% and 6.9% respectively. Intolerable pain was observed in 23.3% and 13.8% of groups 1 and 2 respectively (p>0.05. Two patients in spinal group and 5 in local anesthetic group (3 due to severe pain and 2 for unsatisfaction required conversion to general anesthesia or receiving

  5. Using Local Climate Science to Educate "Key Influentials" and their Communities in the San Diego Region

    Science.gov (United States)

    Boudrias, M. A.; Estrada, M.; Anders, S.; Silva-Send, N. J.; Yin, Z.; Schultz, P.; Young, E.

    2012-12-01

    The San Diego Regional Climate Education Partnership has formed an innovative and collaborative team whose mission is to implement a research-based climate science education and communications program to increase knowledge about climate science among highly-influential leaders and their communities and foster informed decision making based on climate science and impacts. The team includes climate scientists, behavioral psychologists, formal and informal educators and communication specialists. The Partnership's strategic plan has three major goals: (1) raise public understanding of the causes and consequences of climate change; (2) identify the most effective educational methods to educate non-traditional audiences (Key Influentials) about the causes and consequences of climate change; and (3) develop and implement a replicable model for regional climate change education. To implement this strategic plan, we have anchored our project on three major pillars: (1) Local climate science (causes, impacts and long-term consequences); (2) theoretical, research-based evaluation framework (TIMSI); and (3) Key! Influentials (KI) as primary audience for messages (working w! ith and through them). During CCEP-I, the Partnership formed and convened an advisory board of Key Influentials, completed interviews with a sample of Key Influentials, conducted a public opinion survey, developed a website (www.sandiego.edu/climate) , compiled inventories on literature of climate science education resources and climate change community groups and local activities, hosted stakeholder forums, and completed the first phase of on an experiment to test the effects of different messengers delivering the same local climate change message via video. Results of 38 KI Interviews provided evidence of local climate knowledge, strong concern about climate change, and deeply held values related to climate change education and regional leadership. The most intriguing result was that while 90% of Key

  6. Transport Pathways and Enhancement Mechanisms within Localized and Non-Localized Transport Regions in Skin Treated with Low-Frequency Sonophoresis and Sodium Lauryl Sulfate

    OpenAIRE

    Polat, Baris E.; Figueroa, Pedro L.; Blankschtein, Daniel; Langer, Robert

    2010-01-01

    Recent advances in transdermal drug delivery utilizing low-frequency sonophoresis (LFS) and sodium lauryl sulfate (SLS) have revealed that skin permeability enhancement is not homogenous across the skin surface. Instead, highly perturbed skin regions, known as localized transport regions (LTRs), exist. Despite these findings, little research has been conducted to identify intrinsic properties and formation mechanisms of LTRs and the surrounding less-perturbed non-LTRs. By independently analyz...

  7. Mapping regional livelihood benefits from local ecosystem services assessments in rural Sahel.

    Directory of Open Access Journals (Sweden)

    Katja Malmborg

    Full Text Available Most current approaches to landscape scale ecosystem service assessments rely on detailed secondary data. This type of data is seldom available in regions with high levels of poverty and strong local dependence on provisioning ecosystem services for livelihoods. We develop a method to extrapolate results from a previously published village scale ecosystem services assessment to a higher administrative level, relevant for land use decision making. The method combines remote sensing (using a hybrid classification method and interviews with community members. The resulting landscape scale maps show the spatial distribution of five different livelihood benefits (nutritional diversity, income, insurance/saving, material assets and energy, and crops for consumption that illustrate the strong multifunctionality of the Sahelian landscapes. The maps highlight the importance of a diverse set of sub-units of the landscape in supporting Sahelian livelihoods. We see a large potential in using the resulting type of livelihood benefit maps for guiding future land use decisions in the Sahel.

  8. Trust and local knowledge production: Interorganisational collaborations in the Sønderborg region, Denmark

    DEFF Research Database (Denmark)

    Skytt, Christine Benna; Winther, Lars

    2011-01-01

    In the knowledge based economy, knowledge production has become increasingly important for the competitiveness of firms, cities and regions and as an explanatory factor of spatial economic dynamics. In an immense amount of literature in economic geography, sociology and economics it has been argued...... or an input in economic relations. The paper broaden the understanding of trust in local knowledge production by suggesting an approach to trust as an inter-personal feeling to be analysed on three different but interrelated scales depending on the socio-spatial contexts of the actors. The approach avoids...... a reification of interorganisational relations as the place for knowledge production but allows an analysis of trust to move between micro-, meso- and macro scales seeing trust as an inter-personal feeling. The conclusion is that trust in diverse socio-spatial contexts takes on different forms at different...

  9. THE PRESENT GLOBAL ECONOMIC DEVELOPMENT AFTER CRISES AND LOCAL AND REGIONAL CONFLICTS

    Directory of Open Access Journals (Sweden)

    Ionel–Lucian SANDU

    2015-06-01

    Full Text Available The actual article is intended to underline the way in which crises and local and regional conflicts nowadays influence the global economic development The dependence of the small states on the actions of the more developed countries, the economic growth accelerated by the scientific-technological developments and the attitude of the geopolitical actors on global context, describe in detail the ideas extracted from the theme of this article. The economic development is necessary, convenient and unavoidable, the main problems appearing when the main raw materials and essential resources for human survival must be insured. The present international relations and the ways in which political-diplomatic differences are solved, support the need of existence and involvement of some organizations and unbiased pacifist forums wherever societies have differences of opinions.

  10. The local-regional networks of radiation protection experts: a necessary tool to strengthen

    International Nuclear Information System (INIS)

    Barbey, P.; Boirie, G.; Barret, Ch.; Barrey, N.

    2008-01-01

    After having recalled the evolution of the legal framework concerning radioprotection and the origin, role and training of the radiation protection experts (PCR in French for Personne Competente en Radioprotection), the author describes the difficulties faced by a PCR on a daily basis. Then, he outlines the interest of a development of local-regional networks between these professionals to promote information transmission and exchange, knowledge updating and so on, and even also to break the isolation of the PCR. He indicates the main objectives of these networks and evokes perspectives, notably after the professional meetings which have been and still are organized twice a year. Two additional and short papers briefly describe the life of one of these networks (the APCRAP, Association des personnes competentes en radioprotection de l'Assistance Publique, association of radiation protection experts belonging to public care services) and briefly present the objectives of the south-western network

  11. Mapping regional livelihood benefits from local ecosystem services assessments in rural Sahel.

    Science.gov (United States)

    Malmborg, Katja; Sinare, Hanna; Enfors Kautsky, Elin; Ouedraogo, Issa; Gordon, Line J

    2018-01-01

    Most current approaches to landscape scale ecosystem service assessments rely on detailed secondary data. This type of data is seldom available in regions with high levels of poverty and strong local dependence on provisioning ecosystem services for livelihoods. We develop a method to extrapolate results from a previously published village scale ecosystem services assessment to a higher administrative level, relevant for land use decision making. The method combines remote sensing (using a hybrid classification method) and interviews with community members. The resulting landscape scale maps show the spatial distribution of five different livelihood benefits (nutritional diversity, income, insurance/saving, material assets and energy, and crops for consumption) that illustrate the strong multifunctionality of the Sahelian landscapes. The maps highlight the importance of a diverse set of sub-units of the landscape in supporting Sahelian livelihoods. We see a large potential in using the resulting type of livelihood benefit maps for guiding future land use decisions in the Sahel.

  12. Mapping regional livelihood benefits from local ecosystem services assessments in rural Sahel

    Science.gov (United States)

    Sinare, Hanna; Enfors Kautsky, Elin; Ouedraogo, Issa; Gordon, Line J.

    2018-01-01

    Most current approaches to landscape scale ecosystem service assessments rely on detailed secondary data. This type of data is seldom available in regions with high levels of poverty and strong local dependence on provisioning ecosystem services for livelihoods. We develop a method to extrapolate results from a previously published village scale ecosystem services assessment to a higher administrative level, relevant for land use decision making. The method combines remote sensing (using a hybrid classification method) and interviews with community members. The resulting landscape scale maps show the spatial distribution of five different livelihood benefits (nutritional diversity, income, insurance/saving, material assets and energy, and crops for consumption) that illustrate the strong multifunctionality of the Sahelian landscapes. The maps highlight the importance of a diverse set of sub-units of the landscape in supporting Sahelian livelihoods. We see a large potential in using the resulting type of livelihood benefit maps for guiding future land use decisions in the Sahel. PMID:29389965

  13. Local and regional factors affecting the chemistry of precipitation in the spanish basque country

    International Nuclear Information System (INIS)

    Ezcurra, A.; Durana, N.; Casado, H.; Lacaux, J.P.; Pham Van Dinh; Garcia, C.

    1991-01-01

    The study deals with near 300 rain events sampled by means of a network of five automatic devices operating from January 1986 to November 1988. The results show that, on a local-scale, the rain chemistry is affected by the marine source of gases and particles. On a regional-scale, values of pH ranging from 5.5 to 4.8 are noticed. The acidity of rain has an anthropogenic origin that is mainly linked to the NO 3 - content. The acidity is reinforced by air flow from continental Europe. By contrast, rain water with a basic character is related to the air fluxes from Southern Spain that increase the rain content in Ca 2+ [fr

  14. Ultra-Wideband Geo-Regioning: A Novel Clustering and Localization Technique

    Directory of Open Access Journals (Sweden)

    Armin Wittneben

    2007-12-01

    Full Text Available Ultra-wideband (UWB technology enables a high temporal resolution of the propagation channel. Consequently, a channel impulse response between transmitter and receiver can be interpreted as signature for their relative positions. If the position of the receiver is known, the channel impulse response indicates the position of the transmitter and vice versa. This work introduces UWB geo-regioning as a clustering and localization method based on channel impulse response fingerprinting, develops a theoretical framework for performance analysis, and evaluates this approach by means of performance results based on measured channel impulse responses. Complexity issues are discussed and performance dependencies on signal-to-noise ratio, a priori knowledge, observation window, and system bandwidth are investigated.

  15. Adaptation of junior orienteers to loads, developing local-regional and special muscular endurance

    Directory of Open Access Journals (Sweden)

    R.Y. Abzalilov

    2017-10-01

    Full Text Available Purpose: complex assessment of junior sport orientation athletes in conditions of concentrated training of local-regional muscular endurance and stroke loads (final part of preparation for competitions. Materials: in the research sport orientation athletes (n=34, age 13-16 years participated. The athletes were divided into tested group (n=17 and group of comparison (n=17. In every group there were 17 boys and girls. The tested group consisted of volunteers, who practiced sport orientation. Comparison group included average distance and steeplechase runners. Results: In system of junior orienteers’ training we found: gender distinctions in carbohydrates and fats consumption (in the ranges of aerobic and anaerobic thresholds; substantial physiological changes in static-kinetic balance (tests with open and closed eyes. Dynamic coefficient of balance in main stance was better in sport orienteers, comparing with runners. Conclusions: it is recommended to fulfill exercises in conditions of stretching, combined with motor actions of speed-power orientation and relaxation.

  16. Modeling prescribed burning experiments and assessing the fire impacts on local to regional air quality

    Science.gov (United States)

    Zhou, L.; Baker, K. R.; Napelenok, S. L.; Elleman, R. A.; Urbanski, S. P.

    2016-12-01

    Biomass burning, including wildfires and prescribed burns, strongly impact the global carbon cycle and are of increasing concern due to the potential impacts on ambient air quality. This modelling study focuses on the evolution of carbonaceous compounds during a prescribed burning experiment and assesses the impacts of burning on local to regional air quality. The Community Multiscale Air Quality (CMAQ) model is used to conduct 4 and 2 km grid resolution simulations of prescribed burning experiments in southeast Washington state and western Idaho state in summer 2013. The ground and airborne measurements from the field experiment are used to evaluate the model performance in capturing surface and aloft impacts from the burning events. Phase partitioning of organic compounds in the plume are studied as it is a crucial step towards understanding the fate of carbonaceous compounds. The sensitivities of ambient concentrations and deposition to emissions are conducted for organic carbon, elemental carbon and ozone to estimate the impacts of fire on air quality.

  17. Carcass and meat quality determination as a tool to promote local meat consumption in outermost regions of Europe

    DEFF Research Database (Denmark)

    Hernandez Castellano, Lorenzo E; Morales-delaNuez, Antonio; Moreno-Indias, Isabel

    2013-01-01

    of this study, therefore, was to evaluate local and imported carcasses and meat quality in order to promote the consumption of local breeds, using the Canary Islands (Spain) as a model for other subtropical outermost regions. For this study 20 half-carcasses from Palmera breed and 20 imported half...

  18. The influence of airflow inlet region modifications on the local efficiency of natural draft cooling tower operation

    OpenAIRE

    Hočevar, Marko; Širok, Brane; Dvoršek, Matjaž; Holeček, Nikola; Donevski, Božin

    2015-01-01

    We present the influence of the cooling tower airflow inlet region modifications at the Šoštanj 4 thermal power plant on cooling tower local efficiency. Local efficiency change was estimated based on temperature fields of drift eliminators before and after the reconstruction of the cooling tower. Temperature fields were measured with thermal vision method. The local reduction of cooling tower efficiency was analyzed based on phenomenological relations of heat transfer obtained from the select...

  19. ENVIRONMENTAL SECURITY IN THE REGION IN THE SERVICE OF SUSTAINABLE DEVELOPMENT OF LOCAL SPATIAL

    Directory of Open Access Journals (Sweden)

    Ljiljana Stošić Mihajlović

    2016-04-01

    Full Text Available A fundamental prerequisite for the existence, growth and development of each social community is environmental safety. In modern conditions of environmental degradation as a global process, it is bound to increase social stratification, ethnic and even religious conflict, conflict and intolerance that threatens the safety of society. It is a notorious fact that the world of Simply is no longer in a position to deal with new shocks. The financial crisis has reduced global economic resilience, while geopolitical tensions and increased social concerns point to the fact that the state and society less able than ever to cope with global challenges, among which is the primary problem of environmental security. In modern countries, political, security and other interests of the citizens' day-to-day modeling, transform, get the content, in accordance with the general civilization changes. In this connection, sustainable local spatial development is crucial conditioned ecological without security region and aims to achieve a balance between current consumption of natural resources and the ability of the system to maintain the level at which future generations will be able to use them. The work represents a contribution to the achievement of environmental security as a new, modern forms of security, and originated from the need to once again draw attention to the evident environmental degradation as an integral part of human security. Ecological security of the region protects the basic components of the environment and determinants of the local spatial development. In fact, safety in the field of protection and preservation of the environment is one of the most important factors Security Council shall contemporary world. In doing so, it is important to emphasize, however, that environmental security has no borders and is a global problem, a task and an obligation.

  20. A regional-scale assessment of local renewable energy resources in Cumbria, UK

    International Nuclear Information System (INIS)

    Gormally, A.M.; Whyatt, J.D.; Timmis, R.J.; Pooley, C.G.

    2012-01-01

    There is increasing focus on the role small-scale decentralised renewable energy developments could play in helping the UK meet its target of over 15% renewable energy by the year 2020 and alter energy behaviours through active community engagement. Upland areas are considered key areas where such community-based developments could occur due to their natural resources and range of community scales. This study uses GIS-based techniques to develop a methodology that assesses the regional-scale potential for community-based renewable electricity across Cumbria and whether a combination of these developments at the community-scale could make a significant contribution to local electricity consumption. This methodology looks at a range of technologies including hydro-power, wind-power, solar PV and bioenergy. The results suggest there is ample resource available for small communities by combining a mix of localised renewable electricity developments, which is highlighted through energy scenarios for a selected community. Further work will investigate whether this potential can be realised in reality by looking at resource resilience and community-level acceptability. - Highlights: ► A mix of wind, solar, bioenergy and hydro-power options are presented for Cumbria, UK. ► High resolution spatial analysis is conducted focussing on localised developments. ► Locations with sufficient renewable electricity potential were identified. ► Renewable options are explored further through a town case study. ► Scenarios consider different scales, mixes and contributions to local energy demand.

  1. Modelling stream-fish functional traits in reference conditions: regional and local environmental correlates.

    Directory of Open Access Journals (Sweden)

    João M Oliveira

    Full Text Available Identifying the environmental gradients that control the functional structure of biological assemblages in reference conditions is fundamental to help river management and predict the consequences of anthropogenic stressors. Fish metrics (density of ecological guilds, and species richness from 117 least disturbed stream reaches in several western Iberia river basins were modelled with generalized linear models in order to investigate the importance of regional- and local-scale abiotic gradients to variation in functional structure of fish assemblages. Functional patterns were primarily associated with regional features, such as catchment elevation and slope, rainfall, and drainage area. Spatial variations of fish guilds were thus associated with broad geographic gradients, showing (1 pronounced latitudinal patterns, affected mainly by climatic factors and topography, or (2 at the basin level, strong upstream-downstream patterns related to stream position in the longitudinal gradient. Maximum native species richness was observed in midsize streams in accordance with the river continuum concept. The findings of our study emphasized the need to use a multi-scale approach in order to fully assess the factors that govern the functional organization of biotic assemblages in 'natural' streams, as well as to improve biomonitoring and restoration of fluvial ecosystems.

  2. Local population impacts of geothermal energy development in the Geysers: Calistoga region

    Energy Technology Data Exchange (ETDEWEB)

    Haven, K.F.; Berg, V.; Ladson, Y.W.

    1980-09-01

    The country-level population increase implications of two long-term geothermal development scenarios for the Geysers region in California are addressed. This region is defined to include the counties of Lake, Sonoma, Mendocino and Napa, all four in northern California. The development scenarios include two components: development for electrical energy production and direct use applications. Electrical production scenarios are derived by incorporating current development patterns into previous development scenarios by both industry and research organizations. The scenarios are made county-specific, specific to the type of geothermal system constructed, and are projected through the year 2000. Separate high growth rate and low growth rate scenarios are developed, based on a set of specified assumptions. Direct use scenarios are estimated from the nature of the available resource, existing local economic and demographic patterns, and available experience with various separate direct use options. From the composite development scenarios, required numbers of direct and indirect employees and the resultant in-migration patterns are estimated. In-migration patterns are compared to current county level population and ongoing trends in the county population change for each of the four counties. From this comparison, conclusions are drawn concerning the contributions of geothermal resource development to future population levels and the significance of geothermally induced population increase from a county planning perspective.

  3. Classifying Dementia Using Local Binary Patterns from Different Regions in Magnetic Resonance Images

    Directory of Open Access Journals (Sweden)

    Ketil Oppedal

    2015-01-01

    Full Text Available Dementia is an evolving challenge in society, and no disease-modifying treatment exists. Diagnosis can be demanding and MR imaging may aid as a noninvasive method to increase prediction accuracy. We explored the use of 2D local binary pattern (LBP extracted from FLAIR and T1 MR images of the brain combined with a Random Forest classifier in an attempt to discern patients with Alzheimer's disease (AD, Lewy body dementia (LBD, and normal controls (NC. Analysis was conducted in areas with white matter lesions (WML and all of white matter (WM. Results from 10-fold nested cross validation are reported as mean accuracy, precision, and recall with standard deviation in brackets. The best result we achieved was in the two-class problem NC versus AD + LBD with total accuracy of 0.98 (0.04. In the three-class problem AD versus LBD versus NC and the two-class problem AD versus LBD, we achieved 0.87 (0.08 and 0.74 (0.16, respectively. The performance using 3DT1 images was notably better than when using FLAIR images. The results from the WM region gave similar results as in the WML region. Our study demonstrates that LBP texture analysis in brain MR images can be successfully used for computer based dementia diagnosis.

  4. Spatial Interpolation of Daily Rainfall Data for Local Climate Impact Assessment over Greater Sydney Region

    Directory of Open Access Journals (Sweden)

    Xihua Yang

    2015-01-01

    Full Text Available This paper presents spatial interpolation techniques to produce finer-scale daily rainfall data from regional climate modeling. Four common interpolation techniques (ANUDEM, Spline, IDW, and Kriging were compared and assessed against station rainfall data and modeled rainfall. The performance was assessed by the mean absolute error (MAE, mean relative error (MRE, root mean squared error (RMSE, and the spatial and temporal distributions. The results indicate that Inverse Distance Weighting (IDW method is slightly better than the other three methods and it is also easy to implement in a geographic information system (GIS. The IDW method was then used to produce forty-year (1990–2009 and 2040–2059 time series rainfall data at daily, monthly, and annual time scales at a ground resolution of 100 m for the Greater Sydney Region (GSR. The downscaled daily rainfall data have been further utilized to predict rainfall erosivity and soil erosion risk and their future changes in GSR to support assessments and planning of climate change impact and adaptation in local scale.

  5. Update on emerging regional techniques and novel local anesthetics in ambulatory anesthesia

    Directory of Open Access Journals (Sweden)

    Szafran MJ

    2015-12-01

    Full Text Available Martin J Szafran, Eldhose Abrahams, Tong Joo Gan Department of Anesthesiology, Stony Brook University, Stony Brook, NY, USA Abstract: New regional anesthetic techniques have been incorporated into the multimodal approach to postoperative analgesia. Blocks such as the transversus abdominis plane block, adductor canal block, and pectoral nerves blocks all show promise as potential tools used in opioid-sparing techniques, but at the same time have significant limitations to their utility. Novel long-acting formulations of local anesthetics further add to the possible benefit of these blocks, but their application to peripheral nerve blocks is currently being investigated and is not well defined. This review focuses on evaluating the relevant anatomy, technique, and indications of several newer peripheral nerve blocks, the emerging evidence supporting the use of liposomal bupivacaine and SABER®-Bupivacaine, and the application of both in ambulatory anesthesia. Keywords: transversus abdominis plane (TAP block, adductor canal block, pectoral nerves block, regional anesthesia, liposomal bupivacaine, SABER®-Bupivacaine

  6. The Making of the Gdańsk Metropolitan Region. Local Discourses of Identities, Powers, and Hopes

    Directory of Open Access Journals (Sweden)

    Czepczyński Mariusz

    2014-12-01

    Full Text Available The process of metropolitanisation of the Gdańsk area is facilitated by public discourse involving local and regional politicians, media, and inhabitants. The discussion is based upon historical narrations, but also local ambitions, hopes and emotions, as well as infrastructural projects and investment attractiveness. Foucault suggests that modern power is a dispersed set of micro-practices, many of which operate through the normalising gaze of surveillance regimes. Gdańsk metropolitan cooperation, competition and encounters make the core of the paper; local and regional unifying initiatives and processes are accompanied by examples of separatism, identity conflicts, and political disagreements

  7. 17 years of grassland management leads to parallel local and regional biodiversity shifts among a wide range of taxonomic groups

    NARCIS (Netherlands)

    Noordwijk, van C.G.E.; Baeten, Lander; Turin, Hans; Heijerman, Theodoor; Alders, Kees; Boer, Peter; Mabelis, A.A.; Siepel, Henk; Berg, Matty P.; Bonte, Dries

    2017-01-01

    Conservation management is expected to increase local biodiversity, but uniform management may lead to biotic homogenization and diversity losses at the regional scale. We evaluated the effects of renewed grazing and cutting management carried out across a whole region, on the diversity of plants

  8. Dependence of hydropower energy generation on forests in the Amazon Basin at local and regional scales

    Science.gov (United States)

    Stickler, Claudia M.; Coe, Michael T.; Costa, Marcos H.; Nepstad, Daniel C.; McGrath, David G.; Dias, Livia C. P.; Rodrigues, Hermann O.; Soares-Filho, Britaldo S.

    2013-01-01

    Tropical rainforest regions have large hydropower generation potential that figures prominently in many nations’ energy growth strategies. Feasibility studies of hydropower plants typically ignore the effect of future deforestation or assume that deforestation will have a positive effect on river discharge and energy generation resulting from declines in evapotranspiration (ET) associated with forest conversion. Forest loss can also reduce river discharge, however, by inhibiting rainfall. We used land use, hydrological, and climate models to examine the local “direct” effects (through changes in ET within the watershed) and the potential regional “indirect” effects (through changes in rainfall) of deforestation on river discharge and energy generation potential for the Belo Monte energy complex, one of the world’s largest hydropower plants that is currently under construction on the Xingu River in the eastern Amazon. In the absence of indirect effects of deforestation, simulated deforestation of 20% and 40% within the Xingu River basin increased discharge by 4–8% and 10–12%, with similar increases in energy generation. When indirect effects were considered, deforestation of the Amazon region inhibited rainfall within the Xingu Basin, counterbalancing declines in ET and decreasing discharge by 6–36%. Under business-as-usual projections of forest loss for 2050 (40%), simulated power generation declined to only 25% of maximum plant output and 60% of the industry’s own projections. Like other energy sources, hydropower plants present large social and environmental costs. Their reliability as energy sources, however, must take into account their dependence on forests. PMID:23671098

  9. local

    Directory of Open Access Journals (Sweden)

    Abílio Amiguinho

    2005-01-01

    Full Text Available The process of socio-educational territorialisation in rural contexts is the topic of this text. The theme corresponds to a challenge to address it having as main axis of discussion either the problem of social exclusion or that of local development. The reasons to locate the discussion in this last field of analysis are discussed in the first part of the text. Theoretical and political reasons are there articulated because the question is about projects whose intentions and practices call for the political both in the theoretical debate and in the choices that anticipate intervention. From research conducted for several years, I use contributions that aim at discuss and enlighten how school can be a potential locus of local development. Its identification and recognition as local institution (either because of those that work and live in it or because of those that act in the surrounding context are crucial steps to progressively constitute school as a partner for development. The promotion of the local values and roots, the reconstruction of socio-personal and local identities, the production of sociabilities and the equation and solution of shared problems were the dimensions of a socio-educative intervention, markedly globalising. This scenario, as it is argued, was also, intentionally, one of transformation and of deliberate change of school and of the administration of the educative territoires.

  10. The relation of CT-determined tumor parameters and local and regional outcome of tonsillar cancer after definitive radiation treatment

    International Nuclear Information System (INIS)

    Hermans, Robert; Op de beeck, Katya; Bogaert, Walter van den; Rijnders, Alexis; Staelens, Lorenzo; Feron, Michel; Bellon, Erwin

    2001-01-01

    Purpose: To investigate the value of CT-derived tumor parameters as predictor of local and regional outcome of tonsillar squamous cell carcinoma treated by definitive radiation therapy. Methods and Materials: The pretreatment CT studies of 112 patients with tonsillar squamous cell carcinoma were reviewed. After redigitizing the films, primary and nodal tumor volume was calculated with the summation-of-areas technique. The nodal CT aspect was graded using a 3-point scale (homogenous, inhomogeneous, and necrotic). Mean follow-up time was 33 months. Actuarial statistical analysis of local and regional outcome was done for each of the covariates; multivariate analysis was performed using Cox's proportional hazards model. Results: In the actuarial analysis, CT-determined primary tumor volume was significantly correlated with local recurrence rate (p<0.05) when all patients were considered, but primary tumor volume did not predict local control within the T2, T3, and T4 category. CT-determined nodal volume was significantly related to regional outcome (p<0.01), but nodal density was not. Total tumor volume was not significantly related to locoregional outcome (p=0.1). In the multivariate analysis, the T and N categories were the independent predictors of local and regional outcomes, respectively. Conclusion: Compared to other head-and-neck sites, primary and nodal tumor volume have only marginal predictive value regarding local and regional outcome after radiation therapy in tonsillar cancer

  11. Interaction between local and regional pollution during Escompte 2001: impact on surface ozone concentrations (IOP2a and 2b)

    Science.gov (United States)

    Cousin, F.; Tulet, P.; Rosset, R.

    2005-03-01

    Escompte, a European programme which took place in the Marseille region in June-July 2001, has been designed as an exhaustive database to be used for the development and validation of air pollution models. The air quality Mesoscale NonHydrostatic Chemistry model (Meso-NH-C) is used to simulate 2 days of an Intensive Observation Period (IOP) documented during the Escompte campaign, June 23 and 24, 2001. We first study the synoptic and local meteorological situation on June 23 and 24, using surface and aircraft measurements. Then, we focus on the pollution episode of June 24. This study emphasizes the deep impact of synoptic and local dynamics on observed ozone concentrations. It is shown that ozone levels are due both to regional and local factors, with highlights of the importance of ozone layering. More generally this confirms, even in an otherwise predominant local sea-breeze regime, the need to consider larger scale regional pollutant transport.

  12. When local extinction and colonization of river fishes can be predicted by regional occupancy: the role of spatial scales.

    Directory of Open Access Journals (Sweden)

    Benjamin Bergerot

    Full Text Available Predicting which species are likely to go extinct is perhaps one of the most fundamental yet challenging tasks for conservation biologists. This is particularly relevant for freshwater ecosystems which tend to have the highest proportion of species threatened with extinction. According to metapopulation theories, local extinction and colonization rates of freshwater subpopulations can depend on the degree of regional occupancy, notably due to rescue effects. However, relationships between extinction, colonization, regional occupancy and the spatial scales at which they operate are currently poorly known.And Findings: We used a large dataset of freshwater fish annual censuses in 325 stream reaches to analyse how annual extinction/colonization rates of subpopulations depend on the regional occupancy of species. For this purpose, we modelled the regional occupancy of 34 fish species over the whole French river network and we tested how extinction/colonization rates could be predicted by regional occupancy described at five nested spatial scales. Results show that extinction and colonization rates depend on regional occupancy, revealing existence a rescue effect. We also find that these effects are scale dependent and their absolute contribution to colonization and extinction tends to decrease from river section to larger basin scales.In terms of management, we show that regional occupancy quantification allows the evaluation of local species extinction/colonization dynamics and reduction of local extinction risks for freshwater fish species implies the preservation of suitable habitats at both local and drainage basin scales.

  13. When local extinction and colonization of river fishes can be predicted by regional occupancy: the role of spatial scales.

    Science.gov (United States)

    Bergerot, Benjamin; Hugueny, Bernard; Belliard, Jérôme

    2013-01-01

    Predicting which species are likely to go extinct is perhaps one of the most fundamental yet challenging tasks for conservation biologists. This is particularly relevant for freshwater ecosystems which tend to have the highest proportion of species threatened with extinction. According to metapopulation theories, local extinction and colonization rates of freshwater subpopulations can depend on the degree of regional occupancy, notably due to rescue effects. However, relationships between extinction, colonization, regional occupancy and the spatial scales at which they operate are currently poorly known. And Findings: We used a large dataset of freshwater fish annual censuses in 325 stream reaches to analyse how annual extinction/colonization rates of subpopulations depend on the regional occupancy of species. For this purpose, we modelled the regional occupancy of 34 fish species over the whole French river network and we tested how extinction/colonization rates could be predicted by regional occupancy described at five nested spatial scales. Results show that extinction and colonization rates depend on regional occupancy, revealing existence a rescue effect. We also find that these effects are scale dependent and their absolute contribution to colonization and extinction tends to decrease from river section to larger basin scales. In terms of management, we show that regional occupancy quantification allows the evaluation of local species extinction/colonization dynamics and reduction of local extinction risks for freshwater fish species implies the preservation of suitable habitats at both local and drainage basin scales.

  14. Architecture of the local spatial data infrastructure for regional climate change research

    Science.gov (United States)

    Titov, Alexander; Gordov, Evgeny

    2013-04-01

    Georeferenced datasets (meteorological databases, modeling and reanalysis results, etc.) are actively used in modeling and analysis of climate change for various spatial and temporal scales. Due to inherent heterogeneity of environmental datasets as well as their size which might constitute up to tens terabytes for a single dataset studies in the area of climate and environmental change require a special software support based on SDI approach. A dedicated architecture of the local spatial data infrastructure aiming at regional climate change analysis using modern web mapping technologies is presented. Geoportal is a key element of any SDI, allowing searching of geoinformation resources (datasets and services) using metadata catalogs, producing geospatial data selections by their parameters (data access functionality) as well as managing services and applications of cartographical visualization. It should be noted that due to objective reasons such as big dataset volume, complexity of data models used, syntactic and semantic differences of various datasets, the development of environmental geodata access, processing and visualization services turns out to be quite a complex task. Those circumstances were taken into account while developing architecture of the local spatial data infrastructure as a universal framework providing geodata services. So that, the architecture presented includes: 1. Effective in terms of search, access, retrieval and subsequent statistical processing, model of storing big sets of regional georeferenced data, allowing in particular to store frequently used values (like monthly and annual climate change indices, etc.), thus providing different temporal views of the datasets 2. General architecture of the corresponding software components handling geospatial datasets within the storage model 3. Metadata catalog describing in detail using ISO 19115 and CF-convention standards datasets used in climate researches as a basic element of the

  15. Regional and local meteorology influences high-resolution tropospheric ozone concentration in the Los Angeles Basin

    Science.gov (United States)

    Koutzoukis, S.; Jenerette, D.; Chandler, M.; Wang, J.; Ge, C.; Ripplinger, J.

    2017-12-01

    Urban air quality and climate directly affect resident health. The Los Angeles (LA) Basin is a highly populated metropolitan area, with widespread point sources of ozone (O3) precursors (NOx , Volatile Organic Compounds, CO) from fossil fuel combustion. The LA basin exists on a coast-to-mountain gradient, with increasing temperatures towards the Transverse Ranges, which rise to 1700m. Frequently not compliant with 8-hour O3 standards, the LA and South Coast Air Basins are designated as severe and extreme non-attainment areas. Summer weather in the LA basin is characterized by a persistent high pressure system, creating an inversion that traps air pollutants, including O3 precursors, coupled with physical geography that blocks prevailing upper atmosphere air flow. These interactions make neighborhood-level O3 levels more variable than common regional models. Over the summer of 2017, we investigated the importance of local meteorology, wind patterns and air temperature, in transporting and mixing ozone precursors from point sources along the coast-to-mountain gradient. We deployed a network of six EPA federal equivalent method ozone and meteorological sensors in three campaigns in the LA basin along the coast-to-mountain transect. Each campaign, we collaborated with citizen scientists to deploy three sensor stations in two, 4 km2 quadrats, for a total of six high-resolution 4 km2 pixels. O3 concentrations vary greatly along the transect. At the coastal sites, daily O3 ranges from 0ppm to 60ppm and the range increases at the inland sites, to 100ppm. At all sites, there was a positive relationship between wind speed, air temperature, and O3 concentration, with increasing correlation inland. The Pearson correlation coefficient between wind speed and O3 concentration doubles from the coast to inland, and triples between air temperature and O3. The site-specific relationships between O3 and wind direction and temperature vary, suggesting neighborhood-effects from local

  16. Microstimulation of the lumbar DRG recruits primary afferent neurons in localized regions of lower limb.

    Science.gov (United States)

    Ayers, Christopher A; Fisher, Lee E; Gaunt, Robert A; Weber, Douglas J

    2016-07-01

    Patterned microstimulation of the dorsal root ganglion (DRG) has been proposed as a method for delivering tactile and proprioceptive feedback to amputees. Previous studies demonstrated that large- and medium-diameter afferent neurons could be recruited separately, even several months after implantation. However, those studies did not examine the anatomical localization of sensory fibers recruited by microstimulation in the DRG. Achieving precise recruitment with respect to both modality and receptive field locations will likely be crucial to create a viable sensory neuroprosthesis. In this study, penetrating microelectrode arrays were implanted in the L5, L6, and L7 DRG of four isoflurane-anesthetized cats instrumented with nerve cuff electrodes around the proximal and distal branches of the sciatic and femoral nerves. A binary search was used to find the recruitment threshold for evoking a response in each nerve cuff. The selectivity of DRG stimulation was characterized by the ability to recruit individual distal branches to the exclusion of all others at threshold; 84.7% (n = 201) of the stimulation electrodes recruited a single nerve branch, with 9 of the 15 instrumented nerves recruited selectively. The median stimulation threshold was 0.68 nC/phase, and the median dynamic range (increase in charge while stimulation remained selective) was 0.36 nC/phase. These results demonstrate the ability of DRG microstimulation to achieve selective recruitment of the major nerve branches of the hindlimb, suggesting that this approach could be used to drive sensory input from localized regions of the limb. This sensory input might be useful for restoring tactile and proprioceptive feedback to a lower-limb amputee. Copyright © 2016 the American Physiological Society.

  17. Influence of local and regional Mediterranean meteorology on SO₂ ground-level concentrations in SE Spain.

    Science.gov (United States)

    Santacatalina, Milagros; Carratalá, Adoración; Mantilla, Enrique

    2011-06-01

    This work presents the results of a 4-year study on sulfur dioxide (SO(2)) ground-level concentrations in an area of southeastern Spain, the L'Alacantí region, where the cement industry is important and coke use extends to other industries as well. The main source of SO(2) emissions in the area was found to be a the Lepold cement plant (one of the two cement plants in the area). The high levels of SO(2) probably extend back to 1920 when this plant began operations. Both local and Mediterranean-scale meteorological processes influence the SO(2) ground-level concentration and together explain the dispersion dynamics of this pollutant. The location and topography of the study zone result in NW Atlantic advections and E-SE sea breezes being the dominant atmospheric circulation patterns in the area. Under stable meteorological conditions, minor local circulations are also relevant to the SO(2) concentration levels. The high frequency of local circulations determines a concentration pattern that changes during the day, with impacts occurring preferentially in a W-NW direction from the source at midday (sea breeze and strong thermal mixture), and in a SE direction at night. This causes the SO(2) concentrations to present well-defined diurnal cycles with well-differentiated shapes depending on the location of the sampling station relative to the source. The dependence of SO(2) 10 min levels on the wind origin and speed throughout the day has been evaluated by studying statistical parameters including P95, P50 and arithmetic mean. Exceedances occur under specific dispersion conditions at distances less than 1 km from the source. However, the source is traceable at larger distances and the levels are higher than typical urban ones. P95 was used as an estimator of the occurrence of larger levels or impacts. Leeward of NW winds and the source, at night and in early morning, P95 levels are comprised between 30 and 55 µg m(-3). In contrast, with SE winds and at midday, P95

  18. Three-dimensional crustal structure for the Mendocino Triple Junction region from local earthquake travel times

    Energy Technology Data Exchange (ETDEWEB)

    Verdonck, D.; Zandt, G. [Lawrence Livermore National Lab., CA (United States)

    1994-12-10

    The large-scale, three-dimensional geometry of the Mendocino Triple Junction at Cape Mendocino, California, was investigated by inverting nearly 19,000 P wave arrival times from over 1400 local earthquakes to estimate the three-dimensional velocity structure and hypocentral parameters. A velocity grid 175 km (N-S) by 125 km (E-W) centered near Garberville, California, was constructed with 25 km horizontal and 5 km vertical node spacing. The model was well resolved near Cape Mendocino, where the earthquakes and stations are concentrated. At about 40.6{degrees}N latitude a high-velocity gradient between 6.5 and 7.5 km/s dips gently to the south and east from about 15 km depth near the coast. Relocated hypocenters concentrate below this high gradient which the authors interpret as the oceanic crust of the subducted Gorda Plate. Therefore the depth to the top of the Gorda Plate near Cape Mendocino is interpreted to be {approximately} 15 km. The Gorda Plate appears intact and dipping {approximately}8{degrees} eastward due to subduction and flexing downward 6{degrees}-12{degrees} to the south. Both hypocenters and velocity structure suggest that the southern edge of the plate intersects the coastline at 40.3{degrees}N latitude and maintains a linear trend 15{degrees} south of east to at least 123{degrees}W longitude. The top of a large low-velocity region at 20-30 km depth extends about 50 km N-S and 75 km E-W (roughly between Garberville and Covelo) and is located above and south of the southern edge of the Gorda Plate. The authors interpret this low velocity area to be locally thickened crust (8-10 km) due to either local compressional forces associated with north-south compression caused by the northward impingement of the rigid Pacific Plate or by underthrusting of the base of the accretionary subduction complex at the southern terminous of the Cascadia Subduction Zone. 66 refs., 11 figs., 3 tabs.

  19. Regiones ganadoras y regiones perdedoras en el retorno de la democracia en Chile: poderes locales y desequilibrios territoriales

    Directory of Open Access Journals (Sweden)

    Anne-Laure Szary

    1997-12-01

    Full Text Available Abstract The author discusses the regional policies implemented in Chile since the 1960's, emphasizing the practices of the last governments, where an important process of transition has occurred in regional matters (Aylwin, 1990-1994; Frei, 1994- . The analysis is centered on political and economical dimensions, allowing the author to propose a new definition on the fonctionning of the region in Chile, in the frame of globalization processes, introducing a critical question on the traditional territorial equilibrium which is practiced today

  20. Local and Regional Impacts of Pollution on Coral Reefs along the Thousand Islands North of the Megacity Jakarta, Indonesia.

    Science.gov (United States)

    Baum, Gunilla; Januar, Hedi I; Ferse, Sebastian C A; Kunzmann, Andreas

    2015-01-01

    Worldwide, coral reefs are challenged by multiple stressors due to growing urbanization, industrialization and coastal development. Coral reefs along the Thousand Islands off Jakarta, one of the largest megacities worldwide, have degraded dramatically over recent decades. The shift and decline in coral cover and composition has been extensively studied with a focus on large-scale gradients (i.e. regional drivers), however special focus on local drivers in shaping spatial community composition is still lacking. Here, the spatial impact of anthropogenic stressors on local and regional scales on coral reefs north of Jakarta was investigated. Results indicate that the direct impact of Jakarta is mainly restricted to inshore reefs, separating reefs in Jakarta Bay from reefs along the Thousand Islands further north. A spatial patchwork of differentially degraded reefs is present along the islands as a result of localized anthropogenic effects rather than regional gradients. Pollution is the main anthropogenic stressor, with over 80% of variation in benthic community composition driven by sedimentation rate, NO2, PO4 and Chlorophyll a. Thus, the spatial structure of reefs is directly related to intense anthropogenic pressure from local as well as regional sources. Therefore, improved spatial management that accounts for both local and regional stressors is needed for effective marine conservation.

  1. Local and Regional Impacts of Pollution on Coral Reefs along the Thousand Islands North of the Megacity Jakarta, Indonesia.

    Directory of Open Access Journals (Sweden)

    Gunilla Baum

    Full Text Available Worldwide, coral reefs are challenged by multiple stressors due to growing urbanization, industrialization and coastal development. Coral reefs along the Thousand Islands off Jakarta, one of the largest megacities worldwide, have degraded dramatically over recent decades. The shift and decline in coral cover and composition has been extensively studied with a focus on large-scale gradients (i.e. regional drivers, however special focus on local drivers in shaping spatial community composition is still lacking. Here, the spatial impact of anthropogenic stressors on local and regional scales on coral reefs north of Jakarta was investigated. Results indicate that the direct impact of Jakarta is mainly restricted to inshore reefs, separating reefs in Jakarta Bay from reefs along the Thousand Islands further north. A spatial patchwork of differentially degraded reefs is present along the islands as a result of localized anthropogenic effects rather than regional gradients. Pollution is the main anthropogenic stressor, with over 80% of variation in benthic community composition driven by sedimentation rate, NO2, PO4 and Chlorophyll a. Thus, the spatial structure of reefs is directly related to intense anthropogenic pressure from local as well as regional sources. Therefore, improved spatial management that accounts for both local and regional stressors is needed for effective marine conservation.

  2. Local and Regional Impacts of Pollution on Coral Reefs along the Thousand Islands North of the Megacity Jakarta, Indonesia

    Science.gov (United States)

    Baum, Gunilla; Januar, Hedi I.; Ferse, Sebastian C. A.; Kunzmann, Andreas

    2015-01-01

    Worldwide, coral reefs are challenged by multiple stressors due to growing urbanization, industrialization and coastal development. Coral reefs along the Thousand Islands off Jakarta, one of the largest megacities worldwide, have degraded dramatically over recent decades. The shift and decline in coral cover and composition has been extensively studied with a focus on large-scale gradients (i.e. regional drivers), however special focus on local drivers in shaping spatial community composition is still lacking. Here, the spatial impact of anthropogenic stressors on local and regional scales on coral reefs north of Jakarta was investigated. Results indicate that the direct impact of Jakarta is mainly restricted to inshore reefs, separating reefs in Jakarta Bay from reefs along the Thousand Islands further north. A spatial patchwork of differentially degraded reefs is present along the islands as a result of localized anthropogenic effects rather than regional gradients. Pollution is the main anthropogenic stressor, with over 80% of variation in benthic community composition driven by sedimentation rate, NO2, PO4 and Chlorophyll a. Thus, the spatial structure of reefs is directly related to intense anthropogenic pressure from local as well as regional sources. Therefore, improved spatial management that accounts for both local and regional stressors is needed for effective marine conservation. PMID:26378910

  3. Quantifying spatial scaling patterns and their local and regional correlates in headwater streams: implications for resilience

    Directory of Open Access Journals (Sweden)

    Emma Göthe

    2014-09-01

    Full Text Available The distribution of functional traits within and across spatiotemporal scales has been used to quantify and infer the relative resilience across ecosystems. We use explicit spatial modeling to evaluate within- and cross-scale redundancy in headwater streams, an ecosystem type with a hierarchical and dendritic network structure. We assessed the cross-scale distribution of functional feeding groups of benthic invertebrates in Swedish headwater streams during two seasons. We evaluated functional metrics, i.e., Shannon diversity, richness, and evenness, and the degree of redundancy within and across modeled spatial scales for individual feeding groups. We also estimated the correlates of environmental versus spatial factors of both functional composition and the taxonomic composition of functional groups for each spatial scale identified. Measures of functional diversity and within-scale redundancy of functions were similar during both seasons, but both within- and cross-scale redundancy were low. This apparent low redundancy was partly attributable to a few dominant taxa explaining the spatial models. However, rare taxa with stochastic spatial distributions might provide additional information and should therefore be considered explicitly for complementing future resilience assessments. Otherwise, resilience may be underestimated. Finally, both environmental and spatial factors correlated with the scale-specific functional and taxonomic composition. This finding suggests that resilience in stream networks emerges as a function of not only local conditions but also regional factors such as habitat connectivity and invertebrate dispersal.

  4. Actividades predominantes a nivel nacional, regional y local de las PyMEs industriales argentinas

    Directory of Open Access Journals (Sweden)

    Roark, Geraldina Yesica

    2013-06-01

    Full Text Available La creciente importancia e interés que han ido adquiriendo las Pequeñas y Medianas empresas (PyMEs en la actividad económica del país, ha originado la realización de diversos estudios, tanto de instituciones públicas como privadas, que a través de encuestas y registros han caracterizado diferentes temáticas para este tipo de empresas.En este contexto, el Departamento de Ingeniería Industrial de la Facultad de Ingeniería, perteneciente a la Universidad Nacional del Centro de la Provincia de Buenos Aires (UNCPBA, ubicado en la ciudad de Olavarría, se encuentra actualmente desarrollando un proyecto de investigación denominado "Cadena de valor e impacto de las actividades clave en la conducta competitiva de las PyMEs" con el objeto de evaluar sus cadenas de valor y generar propuestas de mejora que impacten positivamente en su competitividad y sustentabilidad en el sector al que pertenecen. Consecuentemente, la relevancia del presente estudio se focaliza en determinar las actividades predominantes de las PyMEs argentinas, a nivel nacional, regional y local, de forma tal de fundamentar la elección de la población objeto de estudio del citado proyecto.

  5. ACTIVIDADES PREDOMINANTES A NIVEL NACIONAL, REGIONAL Y LOCAL DE LAS PYMES INDUSTRIALES ARGENTINAS

    Directory of Open Access Journals (Sweden)

    Geraldina Yesica Roark

    2013-06-01

    Full Text Available La creciente importancia e interés que han ido adquiriendo las Pequeñas y Medianas empresas (PyMEs en la actividad económica del país, ha originado la realización de diversos estudios, tanto de instituciones públicas como privadas, que a través de encuestas y registros han caracterizado diferentes temáticas para este tipo de empresas.En este contexto, el Departamento de Ingeniería Industrial de la Facultad de Ingeniería, perteneciente a la Universidad Nacional del Centro de la Provincia de Buenos Aires (UNCPBA, ubicado en la ciudad de Olavarría, se encuentra actualmente desarrollando un proyecto de investigación denominado ¨Cadena de valor e impacto de las actividades clave en la conducta competitiva de las PyMEs¨ con el objeto de evaluar sus cadenas de valor y generar propuestas de mejora que impacten positivamente en su competitividad y sustentabilidad en el sector al que pertenecen. Consecuentemente, la relevancia del presente estudio se focaliza en determinar las actividades predominantes de las PyMEs argentinas, a nivel nacional, regional y local, de forma tal de fundamentar la elección de la población objeto de estudio del citado proyecto.

  6. Quantifying spatial scaling patterns and their local and regional correlates in headwater streams: Implications for resilience

    Science.gov (United States)

    Gothe, Emma; Sandin, Leonard; Allen, Craig R.; Angeler, David G.

    2014-01-01

    The distribution of functional traits within and across spatiotemporal scales has been used to quantify and infer the relative resilience across ecosystems. We use explicit spatial modeling to evaluate within- and cross-scale redundancy in headwater streams, an ecosystem type with a hierarchical and dendritic network structure. We assessed the cross-scale distribution of functional feeding groups of benthic invertebrates in Swedish headwater streams during two seasons. We evaluated functional metrics, i.e., Shannon diversity, richness, and evenness, and the degree of redundancy within and across modeled spatial scales for individual feeding groups. We also estimated the correlates of environmental versus spatial factors of both functional composition and the taxonomic composition of functional groups for each spatial scale identified. Measures of functional diversity and within-scale redundancy of functions were similar during both seasons, but both within- and cross-scale redundancy were low. This apparent low redundancy was partly attributable to a few dominant taxa explaining the spatial models. However, rare taxa with stochastic spatial distributions might provide additional information and should therefore be considered explicitly for complementing future resilience assessments. Otherwise, resilience may be underestimated. Finally, both environmental and spatial factors correlated with the scale-specific functional and taxonomic composition. This finding suggests that resilience in stream networks emerges as a function of not only local conditions but also regional factors such as habitat connectivity and invertebrate dispersal.

  7. THE PERCEPTION OF LOCAL GOVERNMENT ON THE DEVELOPMENT OF RURAL TOURISM IN THE REGION CRISANA

    Directory of Open Access Journals (Sweden)

    BARBU IONEL

    2013-12-01

    Full Text Available ment, on the development of this economic activities. We believe that a revision of an important part of approaches that have appeared in the literature in terms of the concept of rural tourism, in terms of methods of analysis of tourism activities and, not least, requiring the use modern techniques for foresight indicators by which to make assessments on these activities.From the literature we can draw a number of conditions necessary for the development of rural tourism and a number of motivations for its support.Implement policies and travel plans is the responsibility of both the administration and the private sector entrepreneurs. The public sector is responsible for policy formulation, research and planning, development of basic infrastructure, the development of certain landmarks, establishing and managing service delivery standards, establishing management measures and recovery planning and environmental protection, setting standards for training and maintaining public health and safety. The private sector is responsible for development of accommodation services, travel agency, the specific activity of commercial enterprises with tourism development and promotion of tourist attractions through specific marketing activities, based on existing infrastructure provided by government public.In this paper we try to find the difficulties, limitations of rural tourism development in Crisana region from perspective of local government.

  8. Impact of local adaptation measures and regional climate change on perceived temperature

    Energy Technology Data Exchange (ETDEWEB)

    Schoetter, Robert; Grawe, David; Hoffmann, Peter; Kirschner, Peter; Heinke Schluenzen, K. [Hamburg Univ. (Germany). Meteorological Inst.; Graetz, Angelika [Deutscher Wetterdienst, Freiburg (Germany). Zentrum fuer Medizin-Meteorologische Forschung

    2013-04-15

    The perceived temperature (PT) is a measure for the quantification of human thermal comfort developed by the German Meteorological Service (DWD). In the present article, the sensitivity of PT on air temperature, water vapour pressure, wind speed, mean radiant temperature, street canyon width, and building heights is investigated. The mesoscale atmospheric model METRAS is integrated for a domain covering the city of Hamburg at 250 m horizontal resolution to calculate the meteorological input data for PT. The sensitivities of PT are determined by automatic differentiation of the basic DWD program. The sensitivities show how local adaptation measures and regional climate change can influence PT. The sensitivities also allow to estimate how accurate different input variables need to be known in order to achieve a desired accuracy in PT. The results are discussed in detail for 10 June 2007, a cloudless day with advection of warm air masses from south-east. A comparison with results obtained for different synoptic situations during summer is made. The sensitivities of PT on air temperature, water vapour pressure and mean radiant temperature are higher during warm and humid conditions than in situations with thermal comfort. The sensitivity of PT on wind speed is highest for low wind speeds. Around noon, increasing the building heights by 5 m can reduce PT up to 2.4 K due to shading effects in street canyons with aspect ratios above 0.5. After sunset, increasing the building heights by 5 m tends to moderately increase PT due to increased longwave radiation. (orig.)

  9. 15 local climate-energy plans: regions and districts, local leaders of the struggle against climate change

    International Nuclear Information System (INIS)

    2009-01-01

    This report presents some general information, the sectors addressed by the Climate - Energy Plan, the approaches adopted, the plan elaboration process (organisation, participation and governance, diagnosis and challenges identification, communication actions), the actions and their follow-up, the success factors and the improvement opportunities of the Climate-energy Plans elaborated and adopted by different French regions (Alsace, Aquitaine, Basse-Normandie, Champagne-Ardenne, Franche-Comte, Haute-Normandie, Languedoc-Roussillon, Limousin, Nord-Pas-de-Calais, Poitou-Charentes) and districts (Alpes Maritimes, Bas-Rhin, Eure, Seine-Maritime)

  10. Regional climate, local climate and ozone air pollution in Tours and Orleans cities

    International Nuclear Information System (INIS)

    Berthelot, M.

    2006-10-01

    The importance of the relations between climate and the air pollution justifies the interest related to the role of the urban heat island of heat with respect to the night persistence of ozone in urban environment. When the days are favourable with important ozone concentrations, the agglomerations of the area observe a dynamics day laborer of ozone different from that observed in rural environment. The study is undertaken on the towns of Turns and Orleans where the observations of Lig'Air revealed a night persistence of ozone whereas the concentrations drop more quickly in periphery. This phenomenon is remarkable during the little broken down anticyclonic days. The region region Centre is a ground of study privileged for ozone because of its situation in the south-west of the Island of France rich in precursors of ozone. When flow is of continental origin, the Centre area is found then under the influence of the Paris area. The investigation of a study of the air pollution must take into account the notes of the regional climate and local climate. Several preliminary studies must intervene to answer our principal problems. First of all a descriptive study of the regional climate is carried out with the participation of Meteo-France. The current absence of climatic atlas as well as the many disparities of the climate related to extended from the territory partly justify the interest of our study. The regional approach of the climate is also essential for the continuation of work on a finer scale on the agglomerations of Turns and Orleans in order to detect the urban heat island of heat there. Collaboration with Meteo-France and Lig'Air made it possible to establish a satisfying network of measurement making it possible to obtain notable thermal differences between the downtown area and the surrounding rural environment. The correlation between meteorology and the proven air pollution leads us to establish the climatology of ozone. Many are the studies having

  11. Local and regional species diversity of benthic Isopoda (Crustacea) in the deep Gulf of Mexico

    Science.gov (United States)

    Wilson, George D. F.

    2008-12-01

    Recent studies of deep-sea faunas considered the influence of mid-domain models in the distribution of species diversity and richness with depth. In this paper, I show that separating local diversity from regional species richness in benthic isopods clarifies mid-domain effects in the distribution of isopods in the Gulf of Mexico. Deviations from the randomised implied species ranges can be informative to understanding general patterns within the Gulf of Mexico. The isopods from the GoMB study contained 135 species, with a total of 156 species including those from an earlier study. More than 60 species may be new to science. Most families of deep-sea isopods (suborder Asellota) were present, although some were extremely rare. The isopod family Desmosomatidae dominated the samples, and one species of Macrostylis (Macrostylidae) was found in many samples. Species richness for samples pooled within sites ranged from 1 to 52 species. Because species in pooled samples were highly correlated with individuals, species diversity was compared across sites using the expected species estimator ( n=15 individuals, ES 15). Six depth transects had idiosyncratic patterns of ES 15, and transects with the greatest short-range variation in topography, such as basins and canyons, had the greatest short-range disparity. Basins on the deep slope did not have a consistent influence (i.e., relatively higher or lower than surrounding areas) on the comparative species diversity. ES 15 of all transects together showed a weak mid-domain effect, peaking around 1200-1500 m, with low values at the shallowest and deepest samples (Sigsbee Abyssal Plain); no longitudinal (east-west) pattern was found. The regional species pool was analyzed by summing the implied ranges of all species. The species ranges in aggregate did not have significant patterns across longitudes, and many species had broad depth ranges, suggesting that the isopod fauna of the Gulf of Mexico is well dispersed. The summed

  12. Changes in behavioural responses to infrastructure affect local and regional connectivity – a simulation study on pond breeding amphibians

    DEFF Research Database (Denmark)

    Pontoppidan, Maj-Britt; Nachman, Gøsta Støger

    2013-01-01

    An extensive and expanding infrastructural network destroys and fragments natural habitat and has detrimental effect on abundance and population viability of many amphibian species. Roads function as barriers in the landscape. They separate local populations from each other or prevent access...... to necessary resources. Therefore, road density and traffic intensity in a region may have severe impact on regional as well as local connectivity. Amphibians may be able to detect and avoid unsuitable habitat. Individuals’ ability to avoid roads can reduce road mortality but at the same time road...... avoidance behaviour, can increase the barrier effect of the road and reduce connectivity. We use an individual based model to explore how changes in road mortality and road avoidance behaviour affect local and regional connectivity in a population of Moor frogs (Rana arvalis). The results indicate that road...

  13. Increasing bioenergy production on arable land: Does the regional and local climate respond? Germany as a case study

    Science.gov (United States)

    Tölle, Merja H.; Gutjahr, Oliver; Busch, Gerald; Thiele, Jan C.

    2014-03-01

    The extent and magnitude of land cover change effect on local and regional future climate during the vegetation period due to different forms of bioenergy plants are quantified for extreme temperatures and energy fluxes. Furthermore, we vary the spatial extent of plant allocation on arable land and simulate alternative availability of transpiration water to mimic both rainfed agriculture and irrigation. We perform climate simulations down to 1 km scale for 1970-1975 C20 and 2070-2075 A1B over Germany with Consortium for Small-Scale Modeling in Climate Mode. Here an impact analysis indicates a strong local influence due to land cover changes. The regional effect is decreased by two thirds of the magnitude of the local-scale impact. The changes are largest locally for irrigated poplar with decreasing maximum temperatures by 1°C in summer months and increasing specific humidity by 0.15 g kg-1. The increased evapotranspiration may result in more precipitation. The increase of surface radiative fluxes Rnet due to changes in latent and sensible heat is estimated by 5 W m-2locally. Moreover, increases in the surface latent heat flux cause strong local evaporative cooling in the summer months, whereas the associated regional cooling effect is pronounced by increases in cloud cover. The changes on a regional scale are marginal and not significant. Increasing bioenergy production on arable land may result in local temperature changes but not in substantial regional climate change in Germany. We show the effect of agricultural practices during climate transitions in spring and fall.

  14. Landscape change and conservation priorities: Mexican herpetofaunal perspectives at local and regional scales Cambios en el paisaje y prioridades de conservación: una perspectiva herpetofaunística mexicana a escalas local y regional

    Directory of Open Access Journals (Sweden)

    J. Jesús Sigala-Rodríguez

    2009-04-01

    Full Text Available Few studies have demonstrated historical human impact on biodiversity at local and regional scales, largely due to lack of baseline information and long term monitoring for most taxa. In 1958 and 1959 researchers from the Museum of Vertebrate Zoology (MVZ visited the Mexican state of Aguascalientes and increased its documented amphibian and reptile fauna from 21 to 30 species. Using MVZ collections, field notes, and landscape photographs taken during that expedition, we resurveyed those same localities in 2004 to document herpetofaunal changes coincident with greatly increased human activities. Despite its small area, Aguascalientes encompasses several biogeographic regions and the threat of local extinction at species' distributional limits has broader implications for regional biotas. New discoveries raise to 71 the number of species known for that state, but our comparisons suggest a gloomy future for amphibians and reptiles in Aguascalientes. Paradoxically, human impact is managed primarily at state and municipal levels, often devoid of locally relevant context. Our findings illustrate the conservation value of intensive small-scale studies, focused on the natural history of particular species and localities, as complements to large-scale biodiversity assessments on country wide and continental scales.Pocos estudios han demostrado el impacto humano histórico en la biodiversidad a escalas local y regional debido a la carencia de monitoreo para la mayoría de los grupos taxonómicos. En 1958 y 1959 investigadores del Museum of Vertebrate Zoology (MVZ visitaron Aguascalientes, México y elevaron de 21 hasta 30 el número de especies de anfibios y reptiles para el estado. Usando la colección, notas de campo y fotografías de paisaje tomadas durante esas expediciones, visitamos esas localidades en 2004 para documentar cambios en la herpetofauna asociados con el incremento en actividades humanas. En Aguascalientes se encuentran varias regiones

  15. Estimating Aquifer Storage and Recovery (ASR Regional and Local Suitability: A Case Study in Washington State, USA

    Directory of Open Access Journals (Sweden)

    Maria T. Gibson

    2018-01-01

    Full Text Available Developing aquifers as underground water supply reservoirs is an advantageous approach applicable to meeting water management objectives. Aquifer storage and recovery (ASR is a direct injection and subsequent withdrawal technology that is used to increase water supply storage through injection wells. Due to site-specific hydrogeological quantification and evaluation to assess ASR suitability, limited methods have been developed to identify suitability on regional scales that are also applicable at local scales. This paper presents an ASR site scoring system developed to qualitatively assess regional and local suitability of ASR using 9 scored metrics to determine total percent of ASR suitability, partitioned into hydrogeologic properties, operational considerations, and regulatory influences. The development and application of a qualitative water well suitability method was used to assess the potential groundwater response to injection, estimate suitability based on predesignated injection rates, and provide cumulative approximation of statewide and local storage prospects. The two methods allowed for rapid assessment of ASR suitability and its applicability to regional and local water management objectives at over 280 locations within 62 watersheds in Washington, USA. It was determined that over 50% of locations evaluated are suitable for ASR and statewide injection potential equaled 6400 million liters per day. The results also indicate current limitations and/or potential benefits of developing ASR systems at the local level with the intent of assisting local water managers in strategic water supply planning.

  16. Partitioning the regional and local drivers of phylogenetic and functional diversity along temperate elevational gradients on an East Asian peninsula.

    Science.gov (United States)

    Chun, Jung-Hwa; Lee, Chang-Bae

    2018-02-12

    Species-centric approaches to biodiversity in ecological research are limited in their ability to reflect the evolutionary history and functional diversity of community assembly. Recently, the introduction of alternative facets of biodiversity, such as phylogenetic and functional diversity, has shed light on this problem and improved our understanding of the processes underlying biodiversity patterns. Here, we investigated the phylogenetic and functional diversity patterns of α, β and γ components in woody plant assemblages along regional and local elevational gradients in South Korea. Although the patterns of phylogenetic and functional diversity varied along regional and local elevational transects, the main drivers were partitioned into two categories: regional area or climate for phylogenetic diversity, depending on whether the transect was at a regional or local scale; and habitat heterogeneity for functional diversity, which was derived in elevational bands. Moreover, environmental distance was more important than was geographic distance for phylogenetic and functional β diversity between paired elevational bands. These results support the hypothesis that niche-based deterministic processes such as environmental filtering and competitive exclusion are fundamental in structuring woody plant assemblages along temperate elevational gradients regardless of scale (regional vs. local) in our study areas.

  17. Improved quantification for local regions of interest in preclinical PET imaging

    Science.gov (United States)

    Cal-González, J.; Moore, S. C.; Park, M.-A.; Herraiz, J. L.; Vaquero, J. J.; Desco, M.; Udias, J. M.

    2015-09-01

    In Positron Emission Tomography, there are several causes of quantitative inaccuracy, such as partial volume or spillover effects. The impact of these effects is greater when using radionuclides that have a large positron range, e.g. 68Ga and 124I, which have been increasingly used in the clinic. We have implemented and evaluated a local projection algorithm (LPA), originally evaluated for SPECT, to compensate for both partial-volume and spillover effects in PET. This method is based on the use of a high-resolution CT or MR image, co-registered with a PET image, which permits a high-resolution segmentation of a few tissues within a volume of interest (VOI) centered on a region within which tissue-activity values need to be estimated. The additional boundary information is used to obtain improved activity estimates for each tissue within the VOI, by solving a simple inversion problem. We implemented this algorithm for the preclinical Argus PET/CT scanner and assessed its performance using the radionuclides 18F, 68Ga and 124I. We also evaluated and compared the results obtained when it was applied during the iterative reconstruction, as well as after the reconstruction as a postprocessing procedure. In addition, we studied how LPA can help to reduce the ‘spillover contamination’, which causes inaccurate quantification of lesions in the immediate neighborhood of large, ‘hot’ sources. Quantification was significantly improved by using LPA, which provided more accurate ratios of lesion-to-background activity concentration for hot and cold regions. For 18F, the contrast was improved from 3.0 to 4.0 in hot lesions (when the true ratio was 4.0) and from 0.16 to 0.06 in cold lesions (true ratio  =  0.0), when using the LPA postprocessing. Furthermore, activity values estimated within the VOI using LPA during reconstruction were slightly more accurate than those obtained by post-processing, while also visually improving the image contrast and uniformity

  18. Knock-In Mice with NOP-eGFP Receptors Identify Receptor Cellular and Regional Localization.

    Science.gov (United States)

    Ozawa, Akihiko; Brunori, Gloria; Mercatelli, Daniela; Wu, Jinhua; Cippitelli, Andrea; Zou, Bende; Xie, Xinmin Simon; Williams, Melissa; Zaveri, Nurulain T; Low, Sarah; Scherrer, Grégory; Kieffer, Brigitte L; Toll, Lawrence

    2015-08-19

    The nociceptin/orphanin FQ (NOP) receptor, the fourth member of the opioid receptor family, is involved in many processes common to the opioid receptors including pain and drug abuse. To better characterize receptor location and trafficking, knock-in mice were created by inserting the gene encoding enhanced green fluorescent protein (eGFP) into the NOP receptor gene (Oprl1) and producing mice expressing a functional NOP-eGFP C-terminal fusion in place of the native NOP receptor. The NOP-eGFP receptor was present in brain of homozygous knock-in animals in concentrations somewhat higher than in wild-type mice and was functional when tested for stimulation of [(35)S]GTPγS binding in vitro and in patch-clamp electrophysiology in dorsal root ganglia (DRG) neurons and hippocampal slices. Inhibition of morphine analgesia was equivalent when tested in knock-in and wild-type mice. Imaging revealed detailed neuroanatomy in brain, spinal cord, and DRG and was generally consistent with in vitro autoradiographic imaging of receptor location. Multicolor immunohistochemistry identified cells coexpressing various spinal cord and DRG cellular markers, as well as coexpression with μ-opioid receptors in DRG and brain regions. Both in tissue slices and primary cultures, the NOP-eGFP receptors appear throughout the cell body and in processes. These knock-in mice have NOP receptors that function both in vitro and in vivo and appear to be an exceptional tool to study receptor neuroanatomy and correlate with NOP receptor function. The NOP receptor, the fourth member of the opioid receptor family, is involved in pain, drug abuse, and a number of other CNS processes. The regional and cellular distribution has been difficult to determine due to lack of validated antibodies for immunohistochemical analysis. To provide a new tool for the investigation of receptor localization, we have produced knock-in mice with a fluorescent-tagged NOP receptor in place of the native NOP receptor. These

  19. Brain local and regional neuroglial alterations in Alzheimer's Disease: cell types, responses and implications.

    Science.gov (United States)

    Toledano, Adolfo; Álvarez, María-Isabel; Toledano-Díaz, Adolfo; Merino, José-Joaquín; Rodríguez, José Julio

    2016-01-01

    From birth to death, neurons are dynamically accompanied by neuroglial cells in a very close morphological and functional relationship. Three families have been classically considered within the CNS: astroglia, oligodendroglia and microglia. Many types/subtypes (including NGR2+ cells), with a wide variety of physiological and pathological effects on neurons, have been described using morphological and immunocytochemical criteria. Glio-glial, glio-neuronal and neuro-glial cell signaling and gliotransmission are phenomena that are essential to support brain functions. Morphofunctional changes resulting from the plasticity of all the glial cell types parallel the plastic neuronal changes that optimize the functionality of neuronal circuits. Moreover, neuroglia possesses the ability to adopt a reactive status (gliosis) in which, generally, new functions arise to improve and restore if needed the neural functionality. All these features make neuroglial cells elements of paramount importance when attempting to explain any physiological or pathological processes in the CNS, because they are involved in both, neuroprotection/neurorepair and neurodegeneration. There exist diverse and profound, regional and local, neuroglial changes in all involutive processes (physiological and pathological aging; neurodegenerative disorders, including Alzheimer ´s disease -AD-), but today, the exact meaning of such modifications (the modifications of the different neuroglial types, in time and place), is not well understood. In this review we consider the different neuroglial cells and their responses in order to understand the possible role they fulfill in pathogenesis, diagnosis and treatment (preventive or palliative) of AD. The existence of differentiated and/or concurrent pathogenic and neuro-protective/neuro-restorative astroglial and microglial responses is highlighted.

  20. The value added of conducting regional versus local stakeholder involvement in evaluating technology acceptance

    International Nuclear Information System (INIS)

    McCabe, G.H.

    1995-06-01

    Battelle has conducted a three-year effort, funded by the U. S Department of Energy's (DOE) Office of Technology Development, to involve stakeholders in evaluating innovative technologies to clean up volatile organic compound (VOC) contamination at arid sites. Stakeholders have been encouraged to participate in the demonstration of these innovative technologies in order to improve decisions made by DOE and its contractors about technology development, demonstration, and deployment. The basic approach is to identify people and organizations with a stake in the remediation process, and hence in the demonstration of innovative technologies. Stakeholders have included public interest group and environmental group representatives, regulators, technology users, Native Americans, Hispanic community members, and local elected officials. These people are invited to be involved and they are presented with substantive information about the technologies. Their input in terms of identifying issues and concerns, defining the kinds of information needed from the demonstrations, and assessing the acceptability of the technologies for deployment, will help ensure that only broadly promising technologies are carried forward. This approach is designed to increase the likelihood of successful deployment of the new technologies needed to accomplish environmental restoration throughout the DOE complex and at private facilities. The hypothesis in conducting this regional stakeholder involvement program is that there will be different data requirements for different sites due to geographical, institutional, programmatic, and cultural differences at the sites. Identifying the broadest set of data requirements, collecting this information during the technology demonstration, and providing the results of the demonstration to stakeholders will enhance the acceptance of the technology at these sites and, thereby, enhance the technology's deployability

  1. Local and regional sources of fine and coarse particulate matter based on traffic and background monitoring

    Science.gov (United States)

    Dimitriou, Konstantinos; Kassomenos, Pavlos

    2014-05-01

    The aim of this study was to identify local and exogenous sources affecting particulate matter (PM) levels in five major cities of Northern Europe namely: London, Paris, Hamburg, Copenhagen and Stockholm. Besides local emissions, PM profile at urban and suburban areas of the European Union (EU) is also influenced by regional PM sources due to atmospheric transport, thus geographical city distribution is of a great importance. At each city, PM10, PM2.5, NO2, SO2, CO and O3 air pollution data from two air pollution monitoring stations of the EU network were used. Different background characteristics of the selected two sampling sites at each city facilitated comparisons, providing a more exact analysis of PM sources. Four source apportionment methods: Pearson correlations among the levels of particulates and gaseous pollutants, characterisation of primal component analysis components, long-range transport analysis and extrapolation of PM size distribution ratios were applied. In general, fine (PM2.5) and coarse (PM10) particles were highly correlated, thus common sources are suggested. Combustion-originated gaseous pollutants (CO, NO2, SO2) were strongly associated to PM10 and PM2.5, primarily at areas severely affected by traffic. On the contrary, at background stations neighbouring important natural sources of particles or situated in suburban areas with rural background, natural emissions of aerosols were indicated. Series of daily PM2.5/PM10 ratios showed that minimum fraction values were detected during warm periods, due to higher volumes of airborne biogenic PM coarse, mainly at stations with important natural sources of particles in their vicinity. Hybrid single-particle Lagrangian integrated trajectory model was used, in order to extract 4-day backward air mass trajectories that arrived in the five cities which are under study during days with recorded PM10 exceedances. At all five cities, a significantly large fraction of those trajectories were classified

  2. Intra and inter-continental aerosol transport and local and regional impacts

    Science.gov (United States)

    Charles, Leona Ann Marie

    Under the Clean Air Act, the Environmental Protection Agency (EPA) is required to establish a nationally uniform air quality index for the reporting of air quality. In 1976, the EPA established this index, then called the Pollutant Standards Index, for use by state and local communities across the country. The Index provides information on pollutant concentrations for ground-level ozone, particulate matter, carbon monoxide, sulfur dioxide, and nitrogen dioxide. On July 18, 1997, the EPA revised the ozone and particulate matter standards, in light of a comprehensive review of new scientific evidence including refined fine particulate matter standards.* Any program which is designed to improve air quality must devise tools in which emissions, meteorology, air chemistry and transport are understood. Clearly, the complexity of this task requires measurements at both regional and mesoscale ranges, as well as on a continental scale to investigate long range transport. Unfortunately, determination of fine particulate matter (PM) concentrations is particularly difficult since an accurate measurement of PM2.5 relies on costly equipment which cannot provide the complete transport story and the mixing and dispersion of particulate matter is much more complex than that for trace gases. Besides the need for accurate measurements as a way of documenting air quality standards, the EPA is required in the near future to implement a 24 hour Air Quality Forecast. Current forecast tools are usually based on emission inventories and meteorological forecasts, but significant work is being done in trying to assimilate both ground measurements as well as satellite measurements into these schemes. Clearly, the 'Holy Grail' would be the capability of assimilating full 3D (+ time) measurements. However, since satellite measurements are primarily passive, only total air column properties such as aerosol optical depth can be retrieved. In particular, it is not possible to determine the

  3. Regional Lymph Node Uptake of [{sup 18}F]Fluorodeoxyglucose After Definitive Chemoradiation Therapy Predicts Local-Regional Failure of Locally Advanced Non-Small Cell Lung Cancer: Results of ACRIN 6668/RTOG 0235

    Energy Technology Data Exchange (ETDEWEB)

    Markovina, Stephanie [Mallinckrodt Institute of Radiology and Alvin J. Siteman Cancer Center, Washington University School of Medicine, St. Louis, Missouri (United States); Duan, Fenghai [Department of Biostatistics and Center for Statistical Sciences, Brown University School of Public Health, Providence, Rhode Island (United States); Snyder, Bradley S. [Center for Statistical Sciences, Brown University School of Public Health, Providence, Rhode Island (United States); Siegel, Barry A. [Mallinckrodt Institute of Radiology and Alvin J. Siteman Cancer Center, Washington University School of Medicine, St. Louis, Missouri (United States); Machtay, Mitchell [Department of Radiation Oncology, Case Western Reserve University, Cleveland, Ohio (United States); Bradley, Jeffrey D., E-mail: jbradley@radonc.wustl.edu [Mallinckrodt Institute of Radiology and Alvin J. Siteman Cancer Center, Washington University School of Medicine, St. Louis, Missouri (United States)

    2015-11-01

    Purpose: The American College of Radiology Imaging Network (ACRIN) 6668/Radiation Therapy Oncology Group (RTOG) 0235 study demonstrated that standardized uptake values (SUV) on post-treatment [{sup 18}F]fluorodeoxyglucose-positron emission tomography (FDG-PET) correlated with survival in locally advanced non-small cell lung cancer (NSCLC). This secondary analysis determined whether SUV of regional lymph nodes (RLNs) on post-treatment FDG-PET correlated with patient outcomes. Methods and Materials: Included for analysis were patients treated with concurrent chemoradiation therapy, using radiation doses ≥60 Gy, with identifiable FDG-avid RLNs (distinct from primary tumor) on pretreatment FDG-PET, and post-treatment FDG-PET data. ACRIN core laboratory SUV measurements were used. Event time was calculated from the date of post-treatment FDG-PET. Local-regional failure was defined as failure within the treated RT volume and reported by the treating institution. Statistical analyses included Wilcoxon signed rank test, Kaplan-Meier curves (log rank test), and Cox proportional hazards regression modeling. Results: Of 234 trial-eligible patients, 139 (59%) had uptake in both primary tumor and RLNs on pretreatment FDG-PET and had SUV data from post-treatment FDG-PET. Maximum SUV was greater for primary tumor than for RLNs before treatment (P<.001) but not different post-treatment (P=.320). Post-treatment SUV of RLNs was not associated with overall survival. However, elevated post-treatment SUV of RLNs, both the absolute value and the percentage of residual activity compared to the pretreatment SUV were associated with inferior local-regional control (P<.001). Conclusions: High residual metabolic activity in RLNs on post-treatment FDG-PET is associated with worse local-regional control. Based on these data, future trials evaluating a radiation therapy boost should consider inclusion of both primary tumor and FDG-avid RLNs in the boost volume to maximize local-regional

  4. Homeland Security Knowledge Management for Local Law Enforcement in the National Capital Region

    National Research Council Canada - National Science Library

    Walker, Deirdre I

    2005-01-01

    .... Using existing knowledge (derived primarily from the emergency management field), police agencies have worked to develop locally relevant, viable and available expertise in the developing field of HLS...

  5. LOCAL BRAND DEVELOPMENT IN THE CONTEXT OF REGIONALIZATION AND EUROPEAN INTEGRATION

    Directory of Open Access Journals (Sweden)

    Florin Alexandru LUCA

    2014-11-01

    Full Text Available Currently Romania is in the process of regionalization whose foundations were laid in the "Green Paper regional development in Romania", elaborated under the aegis of the EU Delegation in our country. Regional development is a defining concept of EU construction and at the same time it constitutes a monitoring parameter of any country that wishes to join this structure. Not incidentally, one of the most important directions of the European Commission is called "Regional development and social cohesion”. Against the background of regional development trends, the brand of the region is the one that will make the difference. The concept of branding applied to countries, cities and regions began to be used in the mid-90s in order to support these geographical areas in their fierce competition in the competitive environment. In this era of "super-brands" is nothing unusual to consider a city, a country or a region as being a successful brand.

  6. Defining the spatial scale in modern regional analysis new challenges from data at local level

    CERN Document Server

    Fernández Vázquez, Esteban

    2014-01-01

    This book discusses the concept of region, including techniques of ecological inference applied to estimating disaggregated data from observable aggregates. The final part presents applications in line with the functional areas definition in regional analysis.

  7. Regional localization of DNA probes on the short arm of chromosome 11 using aniridia-Wilms' tumor-associated deletions

    NARCIS (Netherlands)

    Mannens, M.; Slater, R. M.; Heyting, C.; Geurts van Kessel, A.; Goedde-Salz, E.; Frants, R. R.; van Ommen, G. J.; Pearson, P. L.

    1987-01-01

    We are interested in the precise localization of various DNA probes on the short arm of chromosome 11 for our research on the aniridia-Wilms' tumor association (AWTA), assigned to region 11p13 (Knudson and Strong 1972; Riccardi et al. 1978). For this purpose we have screened lymphocyte DNA and

  8. Overview of EPA tools for supporting local- and regional-scale decision makers addressing energy and environmental issues

    Science.gov (United States)

    EPA’s Office of Research and Development (ORD) has been developing tools and illustrative case studies for decision makers in local and regional authorities who are facing challenges of establishing resilience to extreme weather events, aging built environment and infrastru...

  9. Improved estimates of net primary productivity from MODIS satellite data at regional and local scales

    Science.gov (United States)

    Yude Pan; Richard Birdsey; John Hom; Kevin McCullough; Kenneth Clark

    2006-01-01

    We compared estimates of net primary production (NPP) from the MODIS satellite with estimates from a forest ecosystem process model (PnET-CN) and forest inventory and analysis (FIA) data for forest types of the mid-Atlantic region of the United States. The regional means were similar for the three methods and for the dominant oak? hickory forests in the region. However...

  10. Infrastructure and Local Agenda 21: The Municipality of Albertslund in the Copenhagen Region

    DEFF Research Database (Denmark)

    Elle, Morten

    2001-01-01

    The Chapter explores the future of technical networks from the perspective of local aspirations for sustainable forms of flow management as expressed by LA21 intiatives......The Chapter explores the future of technical networks from the perspective of local aspirations for sustainable forms of flow management as expressed by LA21 intiatives...

  11. Infrastructure and Local Agenda 21: the Municipality of Albertslund in the Copenhagen Region

    DEFF Research Database (Denmark)

    Elle, Morten

    1998-01-01

    A case-study on how the visions of the professional flow managers and the central Local Agenda 21 actors interconnect.......A case-study on how the visions of the professional flow managers and the central Local Agenda 21 actors interconnect....

  12. Fast food restaurant locations according to socioeconomic disadvantage, urban–regional locality, and schools within Victoria, Australia

    Directory of Open Access Journals (Sweden)

    Lukar E. Thornton

    2016-12-01

    Full Text Available Features of the built environment provide opportunities to engage in both healthy and unhealthy behaviours. Access to a high number of fast food restaurants may encourage greater consumption of fast food products. The distribution of fast food restaurants at a state-level has not previously been reported in Australia. Using the location of 537 fast food restaurants from four major chains (McDonald׳s, KFC, Hungry Jacks, and Red Rooster, this study examined fast food restaurant locations across the state of Victoria relative to area-level disadvantage, urban–regional locality (classified as Major Cities, Inner Regional, or Outer Regional, and around schools. Findings revealed greater locational access to fast food restaurants in more socioeconomically disadvantaged areas (compared to areas with lower levels of disadvantage, nearby to secondary schools (compared to primary schools, and nearby to primary and secondary schools within the most disadvantaged areas of the major city region (compared to primary and secondary schools in areas with lower levels of disadvantage. Adjusted models showed no significant difference in location according to urban–regional locality. Knowledge of the distribution of fast food restaurants in Australia will assist local authorities to target potential policy mechanisms, such as planning regulations, where they are most needed. Keywords: Australia, Fast food, Socioeconomic inequalities, Urbanicity, Schools, Land-use planning

  13. Fast food restaurant locations according to socioeconomic disadvantage, urban-regional locality, and schools within Victoria, Australia.

    Science.gov (United States)

    Thornton, Lukar E; Lamb, Karen E; Ball, Kylie

    2016-12-01

    Features of the built environment provide opportunities to engage in both healthy and unhealthy behaviours. Access to a high number of fast food restaurants may encourage greater consumption of fast food products. The distribution of fast food restaurants at a state-level has not previously been reported in Australia. Using the location of 537 fast food restaurants from four major chains (McDonald׳s, KFC, Hungry Jacks, and Red Rooster), this study examined fast food restaurant locations across the state of Victoria relative to area-level disadvantage, urban-regional locality (classified as Major Cities, Inner Regional, or Outer Regional), and around schools. Findings revealed greater locational access to fast food restaurants in more socioeconomically disadvantaged areas (compared to areas with lower levels of disadvantage), nearby to secondary schools (compared to primary schools), and nearby to primary and secondary schools within the most disadvantaged areas of the major city region (compared to primary and secondary schools in areas with lower levels of disadvantage). Adjusted models showed no significant difference in location according to urban-regional locality. Knowledge of the distribution of fast food restaurants in Australia will assist local authorities to target potential policy mechanisms, such as planning regulations, where they are most needed.

  14. Surgical Margins and the Risk of Local-Regional Recurrence After Mastectomy Without Radiation Therapy

    International Nuclear Information System (INIS)

    Childs, Stephanie K.; Chen Yuhui; Duggan, Margaret M.; Golshan, Mehra; Pochebit, Stephen; Wong, Julia S.; Bellon, Jennifer R.

    2012-01-01

    Purpose: Although positive surgical margins are generally associated with a higher risk of local-regional recurrence (LRR) for most solid tumors, their significance after mastectomy remains unclear. We sought to clarify the influence of the mastectomy margin on the risk of LRR. Methods and Materials: The retrospective cohort consisted of 397 women who underwent mastectomy and no radiation for newly diagnosed invasive breast cancer from 1998-2005. Time to isolated LRR and time to distant metastasis (DM) were evaluated by use of cumulative-incidence analysis and competing-risks regression analysis. DM was considered a competing event for analysis of isolated LRR. Results: The median follow-up was 6.7 years (range, 0.5-12.8 years). The superficial margin was positive in 41 patients (10%) and close (≤2 mm) in 56 (14%). The deep margin was positive in 23 patients (6%) and close in 34 (9%). The 5-year LRR and DM rates for all patients were 2.4% (95% confidence interval, 0.9-4.0) and 3.5% (95% confidence interval, 1.6-5.3) respectively. Fourteen patients had an LRR. Margin status was significantly associated with time to isolated LRR (P=.04); patients with positive margins had a 5-year LRR of 6.2%, whereas patients with close margins and negative margins had 5-year LRRs of 1.5% and 1.9%, respectively. On univariate analysis, positive margins, positive nodes, lymphovascular invasion, grade 3 histology, and triple-negative subtype were associated with significantly higher rates of LRR. When these factors were included in a multivariate analysis, only positive margins and triple-negative subtype were associated with the risk of LRR. Conclusions: Patients with positive mastectomy margins had a significantly higher rate of LRR than those with a close or negative margin. However, the absolute risk of LRR in patients with a positive surgical margin in this series was low, and therefore the benefit of postmastectomy radiation in this population with otherwise favorable features

  15. Full wave field recording of the vertical strain at SAFOD from local, regional and teleseismic earthquakes

    Science.gov (United States)

    Ellsworth, W. L.; Karrenbach, M. H.; Zumberge, M. A.

    2017-12-01

    The main borehole at the San Andreas Fault Observatory at Depth (SAFOD) contains optical fibers cemented in place in between casing strings from the surface to just below the top of the basement. The fibers are under tension of approximately 1 N and are housed in a 0.9 mm diameter stainless steel tube. Earth strain is transmitted to the fiber by frictional contact with the tube wall. One fiber has been in use as a vertical strainmeter since 2005, measuring the total strain between 9 and 740 m by laser interferometry. In June 2017 we attached an OptaSense Distributed Acoustic Sensing (DAS) system, model ODH3.1, to a second fiber that terminates at 864 m depth. The DAS laser interrogator measures the strain over a gauge length with a set spacing between gauge intervals. For this experiment we set the gauge length to 10 m with 1 m spacing between gauges. Including the surface run of the fiber, this gives us 936 channels measuring the vertical strain at a sample interval of 0.4 msec (2500 samples/s). Continuous recording of the string produces approximately 1 TB/day. During one month of data collection, we recorded local, regional and teleseismic earthquakes. With this recording geometry, the DAS system captures the full vertical wavefield between the basement interface and free surface, revealing direct, converted and refracted waves. Both P- and S- strain waves are clearly visible in the data, even for 10 km deep earthquakes located almost directly below the well (see figure). The incident and surface reflected wavefields can be separated by frequency-wavenumber filtering due to the large-aperture and fine spatial and temporal sampling. Up- and downgoing strain waves illuminate the subsurface within the sensor array's depth range. Accurate arrival time determinations of the initial arrival phase are possible due to consistent wave forms recorded at 1 m spatial intervals that can be used for fine-scale shallow velocity model estimation.

  16. Local extirpations and regional declines of endemic upper beach invertebrates in southern California

    Science.gov (United States)

    Hubbard, D. M.; Dugan, J. E.; Schooler, N. K.; Viola, S. M.

    2014-10-01

    Along the world's highly valued and populous coastlines, the upper intertidal zones of sandy beach ecosystems and the biodiversity that these zones support are increasingly threatened by impacts of human activities, coastal development, erosion, and climate change. The upper zones of beaches typically support invertebrates with restricted distributions and dispersal, making them particularly vulnerable to habitat loss and fragmentation. We hypothesized that disproportionate loss or degradation of these zones in the last century has resulted in declines of upper shore macroinvertebrates in southern California. We identified a suite of potentially vulnerable endemic upper beach invertebrates with direct development, low dispersal and late reproduction. Based on the availability of printed sources and museum specimens, we investigated historical changes in distribution and abundance of two intertidal isopod species (Tylos punctatus, Alloniscus perconvexus) in southern California. Populations of these isopods have been extirpated at numerous historically occupied sites: T. punctatus from 16 sites (57% decrease), and A. perconvexus from 14 sites (64% decrease). During the same period, we found evidence of only five colonization events. In addition, the northern range limit of the southern species, T. punctatus, moved south by 31 km (8% of range on California mainland) since 1971. Abundances of T. punctatus have declined on the mainland coast; only three recently sampled populations had abundances >7000 individuals m-1. For A. perconvexus populations, abundances >100 individuals m-1 now appear to be limited to the northern part of the study area. Our results show that numerous local extirpations of isopod populations have resulted in regional declines and in greatly reduced population connectivity in several major littoral cells of southern California. Two of the six major littoral cells (Santa Barbara and Zuma) in the area currently support 74% of the remaining isopod

  17. Locally-regionally advanced tonsillar squamous cell carcinoma treated with concurrent chemoradiotherapy

    International Nuclear Information System (INIS)

    Krstevska, Valentina; Stojkovski, Igor

    2013-01-01

    Purpose: To perform a retrospective review of stage III-IV squamous cell carcinoma of the tonsil managed by definitive concurrent chemoradiotherapy (CCRT) in order to analyze the patients’ outcome and to evaluate the acute and late toxic effects of this treatment modality. Material and methods: Between January 2005 and December 2010, 36 patients with locally and/or regionally advanced tonsillar cancer underwent three dimensional conformal radiotherapy (3DCRT) with concurrent platinum-based chemotherapy. The dose prescription of the planning target volume for gross tumor and low-risk subclinical disease was 70 Gy and 50 Gy, respectively. Conventional fractionation with a daily dose of 2.0 Gy, 5 times per week was used. Concurrent chemotherapy consisted of cisplatin 30 mg/m2 given on a weekly basis. Acute and late radiotherapy-related toxicities were recorded using European Organization for Research and Treatment of Cancer/Radiation Therapy Oncology Group (EORTC/RTOG) grading system. The 3-year locoregional relapse-free survival (LRRFS), disease-free survival (DFS), and overall survival (OS) rates were calculated using the Kaplan-Meier method. Results: The median follow-up of all patients was 20.5 months (range, 5 to 90 months). The median followup of living patients was 59 months (range, 30 to 90 months). Complete response rates of the primary tumor and of the nodal disease were 72.2% and 64.0%, respectively. A complete composite response was present in 25 patients (69.4%). Treatment failure occurred in 15 out of 25 patients who achieved complete composite response following CCRT. The 3-year LRRFS, DFS, and OS rate was 38.8%, 27.8%, and 27.3%, respectively. Grade 3 mucositis occurred in 58.3% of patients. Xerostomia grade 2 was revealed in 72.2% of patients. Conclusion: Taking into account the low 3-year survival rates observed in our study and the high percentage of grade 2 xerostomia, it can be concluded that in the future, instead of 3DCRT with concurrent

  18. The maintenance of regional dialects: a matter of gender? Boys, but not girls, use local varieties in relation to their friends' nativeness and local identity.

    Science.gov (United States)

    Barbu, Stéphanie; Martin, Nathael; Chevrot, Jean-Pierre

    2014-01-01

    The linguistic diversity enduring beyond institutional pressures and social prejudices against non-standard dialects questions the social forces influencing language maintenance across generations and how children contribute to this process. Children encounter multi-dialectal interactions in their early environment, and increasing evidence shows that the acquisition of sociolinguistic variation is not a side issue but an inherent part of the general acquisition process. Despite these recent advances in sociolinguistic acquisition, children's sociolinguistic uses remain under-studied in relation to peer social networks and the ability to use dialect for identity purposes. Our study focused on a grammatical sociolinguistic variable consisting of the alternation between a regional and a standard variant of the third person object pronoun in French. The regional variant is a remnant of the Francoprovençal language and its usage by adults is strongly associated with local identity in the French Alps. We described, using questionnaires, the social networks of 117 10-11 year-old girls and boys living in the same restricted rural area. Thirteen native target children (7 girls and 6 boys) were selected from the sample, as well as 39 same-sex friends chosen according to their place of birth (native vs. non-native) and the duration of their friendship with the targets (number of years they have known each other). The target children were recorded during spontaneous dyadic conversations during free play at school with each category of friends. Target boys, but not girls, used the regional variant significantly more frequently with their long-term native friends than with their non-native friends. This adjustment mirrored their partners' uses. Moreover, with long-term native friends, boys used the regional variant twice as frequently as girls. Boys appeared thus as key actors in the maintenance and the diffusion of regional cues in local social networks.

  19. The maintenance of regional dialects: a matter of gender? Boys, but not girls, use local varieties in relation to their friends' nativeness and local identity

    Science.gov (United States)

    Barbu, Stéphanie; Martin, Nathael; Chevrot, Jean-Pierre

    2014-01-01

    The linguistic diversity enduring beyond institutional pressures and social prejudices against non-standard dialects questions the social forces influencing language maintenance across generations and how children contribute to this process. Children encounter multi-dialectal interactions in their early environment, and increasing evidence shows that the acquisition of sociolinguistic variation is not a side issue but an inherent part of the general acquisition process. Despite these recent advances in sociolinguistic acquisition, children's sociolinguistic uses remain under-studied in relation to peer social networks and the ability to use dialect for identity purposes. Our study focused on a grammatical sociolinguistic variable consisting of the alternation between a regional and a standard variant of the third person object pronoun in French. The regional variant is a remnant of the Francoprovençal language and its usage by adults is strongly associated with local identity in the French Alps. We described, using questionnaires, the social networks of 117 10–11 year-old girls and boys living in the same restricted rural area. Thirteen native target children (7 girls and 6 boys) were selected from the sample, as well as 39 same-sex friends chosen according to their place of birth (native vs. non-native) and the duration of their friendship with the targets (number of years they have known each other). The target children were recorded during spontaneous dyadic conversations during free play at school with each category of friends. Target boys, but not girls, used the regional variant significantly more frequently with their long-term native friends than with their non-native friends. This adjustment mirrored their partners' uses. Moreover, with long-term native friends, boys used the regional variant twice as frequently as girls. Boys appeared thus as key actors in the maintenance and the diffusion of regional cues in local social networks. PMID:25400617

  20. Preoperative radiochemotherapy in locally advanced or recurrent rectal cancer: regional radiofrequency hyperthermia correlates with clinical parameters

    International Nuclear Information System (INIS)

    Rau, B.; Wust, P.; Tilly, W.; Gellermann, J.; Harder, C.; Riess, H.; Budach, V.; Felix, R.; Schlag, P.M.

    2000-01-01

    Purpose: Preoperative radiochemotherapy (RCT) is a widely used means of treatment for patients suffering from primary, locally advanced, or recurrent rectal cancer. We evaluated the efficacy of treatment due to additional application of regional hyperthermia (HRCT) to this conventional therapy regime in a Phase II study, employing the annular phased-array system BSD-2000 (SIGMA-60 applicator). The clinical results of the trial were encouraging. We investigated the relationship between a variety of thermal and clinical parameters in order to assess the adequacy of thermometry, the effectiveness of hyperthermia therapy, and its potential contribution to clinical endpoints. Methods and Materials: A preoperative combination of radiotherapy (1.8 Gy for 5 days a week, total dose 45 Gy applied over 5 weeks) and chemotherapy (low-dose 5-fluorouracil [5-FU] plus leucovorin in the first and fourth week) was administered to 37 patients with primary rectal cancer (PRC) and 18 patients with recurrent rectal cancer (RRC). Regional hyperthermia (RHT) was applied once a week prior to the daily irradiation fraction of 1.8 Gy. Temperatures were registered along rectal catheters using Bowman thermistors. Measurement points related to the tumor were specified after estimating the section of the catheter in near contact with the tumor. Three patients with local recurrence after abdominoperineal resection, had their catheters positioned transgluteally under CT guidance, where the section of the catheter related to the tumor was estimated from the CT scans. Index temperatures (especially T max , T 90 ) averaged over time, cumulative minutes (cum min) (here for T 90 > reference temperature 40.5 deg. C), and equivalent minutes (equ min) (with respect to 43 deg. C) were derived from repetitive temperature-position scans (5- to 10-min intervals) utilizing software specially developed for this purpose on a PC platform. Using the statistical software package SPSS a careful analysis was

  1. LOCAL GOVERNMENT ROLE IN THE SOLVING OF CATCHING FISH ILLEGALLY IN ACEH REGION

    Directory of Open Access Journals (Sweden)

    Adwani

    2016-01-01

    Full Text Available This study aimed to describe the shape of local government actions in tackling illegal fishing in Aceh, the handling of illegal fishing destructive fishery resources. The fundamental point is Law No. 45 Year 2009 concerning fisheries. This spesification of this research descriptive analysis, used both normative juridical approach and empirical. The results showed that the local government has made an effort preventive and repressive in the case of illegal fishing. To coordinate with relevant agencies and empower the role of traditional institutions of the sea to assist the role of government and law enforcement.Local governments should improve the coordination and supervision of the marine area, to monitor and evaluate the performance of local authorities in applying the law against this illegal fishing case.

  2. Homeland Security Knowledge Management for Local Law Enforcement in the National Capital Region

    National Research Council Canada - National Science Library

    Walker, Deirdre I

    2005-01-01

    .... While local police must effectively address community needs associated with crime and quality of life, they are also now on the front lines of the nation's battle against the forces of international terrorism...

  3. Differential influences of local subpopulations on regional diversity and differentiation for greater sage-grouse (Centrocercus urophasianus)

    Science.gov (United States)

    Row, Jeffery R.; Oyler-McCance, Sara J.; Fedy, Brad C.

    2016-01-01

    The distribution of spatial genetic variation across a region can shape evolutionary dynamics and impact population persistence. Local population dynamics and among-population dispersal rates are strong drivers of this spatial genetic variation, yet for many species we lack a clear understanding of how these population processes interact in space to shape within-species genetic variation. Here, we used extensive genetic and demographic data from 10 subpopulations of greater sage-grouse to parameterize a simulated approximate Bayesian computation (ABC) model and (i) test for regional differences in population density and dispersal rates for greater sage-grouse subpopulations in Wyoming, and (ii) quantify how these differences impact subpopulation regional influence on genetic variation. We found a close match between observed and simulated data under our parameterized model and strong variation in density and dispersal rates across Wyoming. Sensitivity analyses suggested that changes in dispersal (via landscape resistance) had a greater influence on regional differentiation, whereas changes in density had a greater influence on mean diversity across all subpopulations. Local subpopulations, however, varied in their regional influence on genetic variation. Decreases in the size and dispersal rates of central populations with low overall and net immigration (i.e. population sources) had the greatest negative impact on genetic variation. Overall, our results provide insight into the interactions among demography, dispersal and genetic variation and highlight the potential of ABC to disentangle the complexity of regional population dynamics and project the genetic impact of changing conditions.

  4. Regional Distribution Shifts Help Explain Local Changes in Wintering Raptor Abundance: Implications for Interpreting Population Trends

    OpenAIRE

    Paprocki, Neil; Heath, Julie A.; Novak, Stephen J.

    2014-01-01

    Studies of multiple taxa across broad-scales suggest that species distributions are shifting poleward in response to global climate change. Recognizing the influence of distribution shifts on population indices will be an important part of interpreting trends within management units because current practice often assumes that changes in local populations reflect local habitat conditions. However, the individual- and population-level processes that drive distribution shifts may occur across a ...

  5. Regions of mid-level human visual cortex sensitive to the global coherence of local image patches.

    Science.gov (United States)

    Mannion, Damien J; Kersten, Daniel J; Olman, Cheryl A

    2014-08-01

    The global structural arrangement and spatial layout of the visual environment must be derived from the integration of local signals represented in the lower tiers of the visual system. This interaction between the spatially local and global properties of visual stimulation underlies many of our visual capacities, and how this is achieved in the brain is a central question for visual and cognitive neuroscience. Here, we examine the sensitivity of regions of the posterior human brain to the global coordination of spatially displaced naturalistic image patches. We presented observers with image patches in two circular apertures to the left and right of central fixation, with the patches drawn from either the same (coherent condition) or different (noncoherent condition) extended image. Using fMRI at 7T (n = 5), we find that global coherence affected signal amplitude in regions of dorsal mid-level cortex. Furthermore, we find that extensive regions of mid-level visual cortex contained information in their local activity pattern that could discriminate coherent and noncoherent stimuli. These findings indicate that the global coordination of local naturalistic image information has important consequences for the processing in human mid-level visual cortex.

  6. Basic amino acid residues located in the N-terminal region of BEND3 are essential for its nuclear localization

    Energy Technology Data Exchange (ETDEWEB)

    Shiheido, Hirokazu, E-mail: shiheido@ak.med.kyoto-u.ac.jp; Shimizu, Jun

    2015-02-20

    BEN domain-containing protein 3 (BEND3) has recently been reported to function as a heterochromatin-associated protein in transcriptional repression in the nucleus. BEND3 should have nuclear localization signals (NLSs) to localize to the nucleus in light of its molecular weight, which is higher than that allowed to pass through nuclear pore complexes. We here analyzed the subcellular localization of deletion/site-directed mutants of human BEND3 by an immunofluorescence assay in an attempt to identify the amino acids essential for its nuclear localization. We found that three basic amino acid residues located in the N-terminal region of BEND3 (BEND3{sub 56–58}, KRK) are essential, suggesting that these residues play a role as a functional NLS. These results provide valuable information for progressing research on BEND3. - Highlights: • BEND3 localizes to the nucleus. • The N-terminal 60 amino acids region of BEND3 contains NLS. • Amino acids located between 56 and 58 of BEND3 (KRK) are part of NLS. • KRK motif is highly conserved among BEND3 homologs.

  7. Functional analysis of the C-terminal region of human adenovirus E1A reveals a misidentified nuclear localization signal

    Energy Technology Data Exchange (ETDEWEB)

    Cohen, Michael J.; King, Cason R.; Dikeakos, Jimmy D. [Department of Microbiology and Immunology, The University of Western Ontario, A4-833 London Regional Cancer Centre, 800 Commissioners Road E., London, Ontario, N6A 4L6 Canada (Canada); Mymryk, Joe S., E-mail: jmymryk@uwo.ca [Department of Microbiology and Immunology, The University of Western Ontario, A4-833 London Regional Cancer Centre, 800 Commissioners Road E., London, Ontario, N6A 4L6 Canada (Canada); Department of Oncology, The University of Western Ontario, London Regional Cancer Centre, Ontario (Canada)

    2014-11-15

    The immortalizing function of the human adenovirus 5 E1A oncoprotein requires efficient localization to the nucleus. In 1987, a consensus monopartite nuclear localization sequence (NLS) was identified at the C-terminus of E1A. Since that time, various experiments have suggested that other regions of E1A influence nuclear import. In addition, a novel bipartite NLS was recently predicted at the C-terminal region of E1A in silico. In this study, we used immunofluorescence microscopy and co-immunoprecipitation analysis with importin-α to verify that full nuclear localization of E1A requires the well characterized NLS spanning residues 285–289, as well as a second basic patch situated between residues 258 and 263 ({sup 258}RVGGRRQAVECIEDLLNEPGQPLDLSCKRPRP{sup 289}). Thus, the originally described NLS located at the C-terminus of E1A is actually a bipartite signal, which had been misidentified in the existing literature as a monopartite signal, altering our understanding of one of the oldest documented NLSs. - Highlights: • Human adenovirus E1A is localized to the nucleus. • The C-terminus of E1A contains a bipartite nuclear localization signal (NLS). • This signal was previously misidentified to be a monopartite NLS. • Key basic amino acid residues within this sequence are highly conserved.

  8. Functional analysis of the C-terminal region of human adenovirus E1A reveals a misidentified nuclear localization signal

    International Nuclear Information System (INIS)

    Cohen, Michael J.; King, Cason R.; Dikeakos, Jimmy D.; Mymryk, Joe S.

    2014-01-01

    The immortalizing function of the human adenovirus 5 E1A oncoprotein requires efficient localization to the nucleus. In 1987, a consensus monopartite nuclear localization sequence (NLS) was identified at the C-terminus of E1A. Since that time, various experiments have suggested that other regions of E1A influence nuclear import. In addition, a novel bipartite NLS was recently predicted at the C-terminal region of E1A in silico. In this study, we used immunofluorescence microscopy and co-immunoprecipitation analysis with importin-α to verify that full nuclear localization of E1A requires the well characterized NLS spanning residues 285–289, as well as a second basic patch situated between residues 258 and 263 ( 258 RVGGRRQAVECIEDLLNEPGQPLDLSCKRPRP 289 ). Thus, the originally described NLS located at the C-terminus of E1A is actually a bipartite signal, which had been misidentified in the existing literature as a monopartite signal, altering our understanding of one of the oldest documented NLSs. - Highlights: • Human adenovirus E1A is localized to the nucleus. • The C-terminus of E1A contains a bipartite nuclear localization signal (NLS). • This signal was previously misidentified to be a monopartite NLS. • Key basic amino acid residues within this sequence are highly conserved

  9. Multi-region fuzzy logic controller with local PID controllers for U-tube steam generator in nuclear power plant

    Directory of Open Access Journals (Sweden)

    Puchalski Bartosz

    2015-12-01

    Full Text Available In the paper, analysis of multi-region fuzzy logic controller with local PID controllers for steam generator of pressurized water reactor (PWR working in wide range of thermal power changes is presented. The U-tube steam generator has a nonlinear dynamics depending on thermal power transferred from coolant of the primary loop of the PWR plant. Control of water level in the steam generator conducted by a traditional PID controller which is designed for nominal power level of the nuclear reactor operates insufficiently well in wide range of operational conditions, especially at the low thermal power level. Thus the steam generator is often controlled manually by operators. Incorrect water level in the steam generator may lead to accidental shutdown of the nuclear reactor and consequently financial losses. In the paper a comparison of proposed multi region fuzzy logic controller and traditional PID controllers designed only for nominal condition is presented. The gains of the local PID controllers have been derived by solving appropriate optimization tasks with the cost function in a form of integrated squared error (ISE criterion. In both cases, a model of steam generator which is readily available in literature was used for control algorithms synthesis purposes. The proposed multi-region fuzzy logic controller and traditional PID controller were subjected to broad-based simulation tests in rapid prototyping software - Matlab/Simulink. These tests proved the advantage of multi-region fuzzy logic controller with local PID controllers over its traditional counterpart.

  10. The "Fourth Generation University" as a Creator of the Local and Regional Development

    Science.gov (United States)

    Pawlowski, Krzysztof

    2009-01-01

    Beginning with a view of the role of tertiary-level educational institutions in the globalizing world and the condition of the Polish higher education system in 2007, the author presents the factors affecting the regional development as well as those that exert the strongest influence on long-term regional development. While examining current…

  11. The coexistence of traditional medicine and biomedicine: A study with local health experts in two Brazilian regions.

    Science.gov (United States)

    Zank, Sofia; Hanazaki, Natalia

    2017-01-01

    This study investigated the combined use of traditional medicine and biomedicine by local experts in Chapada do Araripe communities (Ceará State) and maroon communities (Santa Catarina State), Brazil. The objective was to understand the perception of local health specialists regarding the number of healers, demand for healers and use of medicinal plants, and the dependence of different environments to obtain such plants. We also aimed to understand the role of medicinal plants to treat different categories of diseases and if there is a complementary use of medicinal plants and allopathic biomedicine, according to the context of each group. The research was conducted with local health specialists that answered structured interviews, created free lists and participated in guided tours to collect cited plants. Sixty-six local health specialists were identified in the Araripe communities and 22 specialists in the maroon communities. In the maroon communities, a greater number of specialists thought there was a decrease in the number and demand for healers, as well as the use of medicinal plants, due to changes in traditional livelihoods, since they are located in a region where the effects of the modernization were more intense. In the Chapada do Araripe communities the specialists knew more plants extracted from native vegetation, whereas in the maroon communities cultivated plants were better known, which may reflect the environmental conditions and the history of each region. Medicinal plants are preferred to treat simpler health problems that do not require medical care, such as gastrointestinal problems, general pain, flues and colds. The biomedicine is used principally for problems with blood pressure, general pains and endocrine and nutritional diseases. Even with the particularities of each region, in general the use of medicinal plants and biomedicines occurred in a complementary form in both regions; however, this coexistence may result from these different

  12. The coexistence of traditional medicine and biomedicine: A study with local health experts in two Brazilian regions

    Science.gov (United States)

    Zank, Sofia; Hanazaki, Natalia

    2017-01-01

    This study investigated the combined use of traditional medicine and biomedicine by local experts in Chapada do Araripe communities (Ceará State) and maroon communities (Santa Catarina State), Brazil. The objective was to understand the perception of local health specialists regarding the number of healers, demand for healers and use of medicinal plants, and the dependence of different environments to obtain such plants. We also aimed to understand the role of medicinal plants to treat different categories of diseases and if there is a complementary use of medicinal plants and allopathic biomedicine, according to the context of each group. The research was conducted with local health specialists that answered structured interviews, created free lists and participated in guided tours to collect cited plants. Sixty-six local health specialists were identified in the Araripe communities and 22 specialists in the maroon communities. In the maroon communities, a greater number of specialists thought there was a decrease in the number and demand for healers, as well as the use of medicinal plants, due to changes in traditional livelihoods, since they are located in a region where the effects of the modernization were more intense. In the Chapada do Araripe communities the specialists knew more plants extracted from native vegetation, whereas in the maroon communities cultivated plants were better known, which may reflect the environmental conditions and the history of each region. Medicinal plants are preferred to treat simpler health problems that do not require medical care, such as gastrointestinal problems, general pain, flues and colds. The biomedicine is used principally for problems with blood pressure, general pains and endocrine and nutritional diseases. Even with the particularities of each region, in general the use of medicinal plants and biomedicines occurred in a complementary form in both regions; however, this coexistence may result from these different

  13. A Local Action Plan (PAL to Combat Desertification in Apulia Region: Functional Integration of Existing Territorial Programs

    Directory of Open Access Journals (Sweden)

    Claudia Trotta

    2010-10-01

    Full Text Available In 2006-2007, the Italian National Committee to Combat Drought and Desertification promoted the execution of local action plans in some of the Italian regions. The aims of these plans were: to carry out specific actions at a local scale; to promote the integration of local policies; to involve the local communities in proposing strategies to be adopted; to harmonize the procedures among institutions in charge of adopting the policies. In this framework, ENEA carried out an evaluation of existing policies and programs to be considered in implementing a local action plan to combat desertification in the Apulia region. The application of the environmental and socio-economic measures of the regional Rural Development Plan 2007-2013 (PSR seemed to be an effective tool to positively influence human activities such as agriculture, breeding, and forestry, with the purpose of preserving or improving soil characteristics and overall environmental conditions, and eventually resulting in a reduction of desertification processes. Therefore, we proposed that these measures should be taken into account and effectively integrated into the Local Action Plan of the Apulia region. Additionally, we considered the four priority sectors identified by the National Action Plan (PAN to combat drought and desertification as the guiding principles to carry out our analysis. These sectors were: Soil Protection, Sustainable Water Management, Reduction of the Impact of Productive Activities, and Territorial Equilibrium. We also included Climate Change, in consideration of the alarming and urgent role it has assumed. The desertification-prone province of Foggia was selected as a pilot area in where to evaluate the influences that PSR measures can directly or indirectly have on desertification-related factors, and identify and implement specific actions. The Provincial Coordination Territorial Plan (PTCP of Foggia provided the basic land units for this analysis, the

  14. Is climate change a threat for water uses in the Mediterranean region? Results from a survey at local scale.

    Science.gov (United States)

    La Jeunesse, I; Cirelli, C; Aubin, D; Larrue, C; Sellami, H; Afifi, S; Bellin, A; Benabdallah, S; Bird, D N; Deidda, R; Dettori, M; Engin, G; Herrmann, F; Ludwig, R; Mabrouk, B; Majone, B; Paniconi, C; Soddu, A

    2016-02-01

    Water scarcity and water security are linked, not only through the direct effects of water shortages on each water users' access to water, but also because of water conflicts generated. Climate change is predicted to raise temperatures in the Mediterranean region and reduce rainfall, leading to a reduction in water yield and possibly worsening the situation of water resource shortages that Mediterranean regions are already experiencing. In its dissemination strategy, the EU FP7 CLIMB project addressed water security threats through an analysis of water uses and water use rivalries within a few target catchments distributed over the Mediterranean region. The present work explores whether climate change is locally perceived by stakeholders (water users and managers) as a key issue for their water uses and water security. Individual interviews, meetings, and compilation of questionnaires were conducted at five sites located in the Mediterranean region. The methodology permitted an analysis of water use and its evolution in the water management context, an identification of the state of awareness of local stakeholders and of the pressures on water use and water use rivalries, and a prioritization of water uses. Currently, the main response to increasing water demand in the Mediterranean region, while not yet considering climate change as a driving force, is a progressive externalization of water resources, with limits represented by national borders and technological possibilities. Overall, 'climate change' was not mentioned by stakeholders during both interviews and in answers to the questionnaires. Even the prospect of decreasing precipitation was not considered a relevant or threatening issue in the coming 20years. This confirms the need to continue all efforts to disseminate the state of knowledge on climate change impacts in the Mediterranean region, such as water scarcity, especially to local water managers, as initiated by various research programs of the

  15. Separate measurement of local diffusion coefficients in grain boundaries and in adjacent regions

    International Nuclear Information System (INIS)

    Klotsman, S.M.; Kajgorodov, V.N.

    1994-01-01

    A new measuring technique is presented that allows one separate determination of grain boundary width and local diffusion coefficients. With the use of the technique presented phenomenological description is accompished for time and temperature dependences of relative and absolute level populations in a zone of preferential intercrystalline diffusion. Local diffusion coefficients obtained for the upper temperature limit of applicability of the technique proposed are in a good agreement with values calculated form coordinate distribution of atoic probes. Local diffusion coefficients determined at lower temperatures essentially differ from those calculated assuming that suction coefficient is equal to a coefficient of volume diffusion. Experimental dta are given for diffusion parameters in Ag, Pd and W polycrystals. 16 refs., 3 figs., 2 tabs

  16. Local and Regional Food Aid Procurement: An Assessment of Experience in Africa and Elements of Good Donor Practice

    OpenAIRE

    Tschirley, David L.; del Castillo, Anne Marie

    2008-01-01

    This Policy Synthesis is a summary of a longer report that discusses the procurement of food aid within the country or region where it is needed. Referred to as local and regional procurement – LRP – this practice has become a major element in multilateral food aid response over the past decade1. The paper examines the relevance and the rationale for using LRP, reviews the efficiency of World Food Program (WFP) LRP activities in Africa relative to inkind food aid and to prices in the markets ...

  17. A Scaling Analysis of Frequency Dependent Energy Partition for Local and Regional Seismic Phases from Explosions

    Science.gov (United States)

    2007-08-31

    explosions at the former Soviet Semipalatinsk test site (STS). Labeled stations are those for which high resolution digital data are available. 12 8...characteristics of regional phase observations from underground nuclear explosions at the former Soviet Semipalatinsk and Novaya Zemlya test sites , the...various regional phases observed from underground nuclear explosions at the former Soviet Semipalatinsk test site (STS). Labeled stations are those for

  18. Improving Suicide Prevention in Dutch Regions by Creating Local Suicide Prevention Action Networks (SUPRANET): A Study Protocol.

    Science.gov (United States)

    Gilissen, Renske; De Beurs, Derek; Mokkenstorm, Jan; Mérelle, Saskia; Donker, Gé; Terpstra, Sanne; Derijck, Carla; Franx, Gerdien

    2017-03-28

    The European Alliance against Depression (EAAD) program is to be introduced in The Netherlands from 2017 onwards. This program to combat suicide consists of interventions on four levels: (1) increasing the awareness of suicide by local media campaigns; (2) training local gatekeepers, such as teachers or police officers; (3) targeting high-risk persons in the community; and (4) training and support of professionals in primary care settings. The implementation starts in seven Dutch pilot regions. Each region is designated as a Suicide Prevention Action NETwork (SUPRANET). This paper describes the SUPRANET program components and the evaluation of its feasibility and impact. The findings will be used to facilitate the national implementation of EAAD in The Netherlands and to add new findings to the existing literature on EAAD.

  19. Climate Change and Coastal Zones. An Overview of the State-of-the-Art on Regional and Local Vulnerability Assessment

    International Nuclear Information System (INIS)

    Sterr, H.; Klein, R.J.T.; Reese, S.

    2000-06-01

    This paper provides an overview of the latest developments in methodologies for assessing the vulnerability of coastal zones to climate change at regional and local scales. The focus of vulnerability assessment in coastal zones used to be on erosion and land loss due to sea-level rise. Methodologies now increasingly consider the wide range of climate and impact variables that play a part in determining coastal vulnerability, as well as non-climatic developments. The paper presents a conceptual framework for vulnerability assessment that identifies a number of system components that can be considered determinants of vulnerability. It then goes on to outline a number of steps that are required for the actual assessment of coastal vulnerability, such as scenario development, data collection and impact assessment. The approach is illustrated using a regional and local case study in Germany

  20. Economic Contribution of Regional Feeder Ports to The Local Economy In Indonesia

    Directory of Open Access Journals (Sweden)

    Ibnu Syabri

    2017-07-01

    Full Text Available Indonesia regional feeder ports’ main function is to serve marine transport activities between regency/city in a province in limited quantities. The intention of the government to make marine transportation as the backbone of national logistic transportation system puts these ports to an important position, as suppliers for the main and/or collector ports and as goods distribution centers for the region from the bigger ports. Not only as a provider of accessibility between regions, regional feeder ports should be seen as an investation to boost regional economy. This study aims to explain the influences of regional feeder ports on regency/city economy, based on the port types: (1 cargo ports, and (2 cargo & passengers ports. Results showed that both types of ports have positive influences on the regency/city economy, although it is not related to region’s economic base sector. Cargo ports which are mainly located on west area of Indonesia, supports the region’s economy more than cargo & passenger ports which are mainly located on the east.

  1. Regional Lymph Node Uptake of ["1"8F]Fluorodeoxyglucose After Definitive Chemoradiation Therapy Predicts Local-Regional Failure of Locally Advanced Non-Small Cell Lung Cancer: Results of ACRIN 6668/RTOG 0235

    International Nuclear Information System (INIS)

    Markovina, Stephanie; Duan, Fenghai; Snyder, Bradley S.; Siegel, Barry A.; Machtay, Mitchell; Bradley, Jeffrey D.

    2015-01-01

    Purpose: The American College of Radiology Imaging Network (ACRIN) 6668/Radiation Therapy Oncology Group (RTOG) 0235 study demonstrated that standardized uptake values (SUV) on post-treatment ["1"8F]fluorodeoxyglucose-positron emission tomography (FDG-PET) correlated with survival in locally advanced non-small cell lung cancer (NSCLC). This secondary analysis determined whether SUV of regional lymph nodes (RLNs) on post-treatment FDG-PET correlated with patient outcomes. Methods and Materials: Included for analysis were patients treated with concurrent chemoradiation therapy, using radiation doses ≥60 Gy, with identifiable FDG-avid RLNs (distinct from primary tumor) on pretreatment FDG-PET, and post-treatment FDG-PET data. ACRIN core laboratory SUV measurements were used. Event time was calculated from the date of post-treatment FDG-PET. Local-regional failure was defined as failure within the treated RT volume and reported by the treating institution. Statistical analyses included Wilcoxon signed rank test, Kaplan-Meier curves (log rank test), and Cox proportional hazards regression modeling. Results: Of 234 trial-eligible patients, 139 (59%) had uptake in both primary tumor and RLNs on pretreatment FDG-PET and had SUV data from post-treatment FDG-PET. Maximum SUV was greater for primary tumor than for RLNs before treatment (P<.001) but not different post-treatment (P=.320). Post-treatment SUV of RLNs was not associated with overall survival. However, elevated post-treatment SUV of RLNs, both the absolute value and the percentage of residual activity compared to the pretreatment SUV were associated with inferior local-regional control (P<.001). Conclusions: High residual metabolic activity in RLNs on post-treatment FDG-PET is associated with worse local-regional control. Based on these data, future trials evaluating a radiation therapy boost should consider inclusion of both primary tumor and FDG-avid RLNs in the boost volume to maximize local-regional control.

  2. Influence of ENSO on Regional Indian Summer Monsoon Precipitation—Local Atmospheric Influences or Remote Influence from Pacific

    Directory of Open Access Journals (Sweden)

    Indrani Roy

    2016-02-01

    Full Text Available Using CMIP5 model outputs in different El Niño-Southern Oscillation (ENSO phases, this work investigates the indicator that could be used as an Index to characterise regional Indian Summer Monsoon (ISM precipitation. Dividing the Indian subcontinent into five arbitrarily chosen regions, viz. Central North East (CNE (18°N–31°N, 86°E–75°E, Hilly (H (28°N–38°N, 85°E–70°E, North West (NW (21°N–31°N, 79°E–67°E, North East (NE (21°N–31°N, 86°E–97°E and Southern India (S (18°N–7°N, 73°E–85°E, local wind field and remote influences from the tropical Pacific are considered to improve understanding of regional monsoon rainfall. Results are also compared with observations/reanalysis data to pinpoint areas of shortcomings and agreements. Model results suggest that regional wind velocity, viz. meridional wind component (V at 850 mb level (V850 and zonal component at 200 mb (U200 and 850 mb (U850 can yield better estimation of local precipitation in regions CNE, H and NW, agreeing well with earlier proposed monsoon Indices. Such observations are independent of different subcategories of ENSO phases and models show good correspondence with observations. Analyses with V at 200 mb (V200 indicate circulation of the upper branch of Hadley cells in regions CNE and S, though suggest the best agreement among models in comparison with other fields, but there are some deviations from observations, indicating a missing mechanism in the models. Using models, this study identified the best parameter in different regions that could be used for the regional monsoon Index, irrespective of various ENSO subcategories; for CNE it is the U200, for H it is U200 and U850, and for NW it is U850. The current analysis, however, fails to indicate anything clearly about the NE region. When focusing on the remote influence from the eastern Pacific region, it is found that atmospheric contribution to regional ISM precipitation fails to indicate

  3. Integration of local participatory and regional planning for resources management using remote sensing and GIS

    NARCIS (Netherlands)

    Sedogo, L.G.

    2002-01-01

    With the introduction of participatory approaches in development programs, it has become essential for planners to build and implement land use strategies based on the objectives, perceptions and knowledge of local people. Despite the richness of participatory rural appraisal (PRA)

  4. OPTIMIZATION OF THE POSITION OF THE LOCAL DISTRIBUTION CENTRE OF THE REGIONAL POST LOGISTICS NETWORK

    Directory of Open Access Journals (Sweden)

    Paweł DROŹDZIEL

    2017-09-01

    Full Text Available The phenomenon of the present postal services is the fact that, customers expect the lowest price while maintaining the availability, security and on time delivery of mail items. We can find that, the costs associated with transport of the postal substrate is one of the most important factors affecting the total cost of the postal services. These transport costs depend on various factors such as the investment in vehicles purchase, operational costs of the postal vehicles (costs of maintenance, repairs, fuel costs of the vehicle, etc. labour costs of the drivers and so on. For this reason, it is important to find such an operational - organizational solutions that can reduce the costs associated with the transportation of postal shipments, resulting in reducing the total cost of postal services. One option to do this is to minimize the length of postal transportation routes. This article presents the approach based on the application of graph theory to optimize existing connections of postal logistics network. Published results is oriented to revaluate existing position of local centre and find a location for the new local distribution centre potentially. New location of local distribution centre can to optimize (minimize the total transport costs of the local postal transportation network in area of the Lublin Province.

  5. Identifying Local Benefits of Early Childhood Development Programs Using Regional Modeling

    Science.gov (United States)

    Temple, Judy A.; Rolnick, Arthur J.

    2012-01-01

    This article presents a review of "Investing in Kids: Early Childhood Programs and Local Economic Development" by Timothy J. Bartik. Timothy Bartik's timely book contributes to an important conversation about the role of government in promoting investments in children in the years before traditional public schooling typically begins. Until…

  6. Local Community Versus Globalization Tendencies: Case Study of Czech Villages in Romanian Banat Region

    Directory of Open Access Journals (Sweden)

    Šantrůčková Markéta

    2014-11-01

    Full Text Available The research question is the relationship between the local community and globalization tendencies and transformation or maintenance of local traditions. The research area is a specific locality of a Czech village in Romanian Banat. The local community has evolved in a relative isolation. Agriculture was the most important activity despite the fact that a mining factory was opened there. Agriculture was and in many features still is traditional, self-supplying, and hard-work. The life-style has always been environmentally friendly as it has been without modern technologies. Nevertheless, modernization exploded dramatically in these villages after 1989, when the communist policies collapsed along with Romania's isolation. People from the Czech Republic have rediscovered Romanian Banat and a rather busy (agro tourism has developed there. The Czech Ministry of Foreign Affairs supports development projects for making living conditions in the village better. Simultaneously, strong migration from Banat to the Czech Republic has started. People find living conditions in the Czech Republic easier and leave hard work, poverty and unemployment. It brings huge land cover changes because people who remain cannot use all arable land, which is thus abandoned and left for the natural process. One of the distinct manifestations of globalization tendencies is the build-up of wind power plants.

  7. The effective obove local development of the spanish regional policy applied through economic incentives during the period 1988-2003

    OpenAIRE

    Pedro Benito, Moyano Pesquera; Aleixandre Mendizábal, Guillermo; Ogando Canabal, Olga

    2006-01-01

    The objective of this paper is to assess the effectiveness of regional incentive policy applied in Spain during the period 1988-2001 at a municipal scale. Specifically, the relation between economic growth and the amount of incentives received by each Spanish municipality is analysed, taking into consideration the characteristics of the subsidised projects and the municipalities concerned. One of the main problems faced was the lack of economic information at a local scale. Therefore, it was ...

  8. A comparative analysis of ecosystem services valuation approaches for application at the local scale and in data scarce regions

    OpenAIRE

    Pandeya, B.; Buytaert, W.; Zulkafli, Z.; Karpouzoglou, T.; Mao, F.; Hannah, D.M.

    2016-01-01

    Despite significant advances in the development of the ecosystem services concept across the science and policy arenas, the valuation of ecosystem services to guide sustainable development remains challenging, especially at a local scale and in data scarce regions. In this paper, we review and compare major past and current valuation approaches and discuss their key strengths and weaknesses for guiding policy decisions. To deal with the complexity of methods used in different valuation approa...

  9. Attainment of MDGs through tourism in the Central African sub-region: Implications for local economic development in Cameroon

    Directory of Open Access Journals (Sweden)

    Albert N. Kimbu

    2012-03-01

    Full Text Available This paper examines the role and contribution of tourism to local economic development and in the attainment of the Millennium Development Goals one and seven dealing with extreme poverty alleviation and environmental sustainability in the biodiversity endowed Central African sub-region. The concepts of sustainable tourism development and local economic development (in sub-Saharan Africa are examined. Through field observations and semi-structured interviews with 21 tourism industry stakeholders in Cameroon, an analysis of tourism’s role and future in LED and in the attainment of the Millennium Development Goals 1 & 7 is undertaken. The core challenges presently inhibiting tourism’s development thereby limiting its contribution to local economic development and the attainment of these goals in Cameroon are identified and a framework within which tourism’s contribution can be increased is proposed.

  10. Calibração regional e local da equação de Hargreaves para estimativa da evapotranspiração de referência Regional and local calibration of Hargreaves equation for estimating reference evapotranspiration

    Directory of Open Access Journals (Sweden)

    Diego Simões Fernandes

    2012-06-01

    Full Text Available A equação de Penman-Monteith FAO-56 (EToPM tem sido recomendada pela FAO, Organização para a Alimentação e Agricultura das Nações Unidas (ONU, como padrão para estimar a evapotranspiração de referência (ETo. Essa equação requer muitas variáveis que não estão disponíveis na maioria das estações meteorológicas no Brasil central. Por outro lado, a equação de Hargreaves é considerada simples e demanda somente dados de temperatura máxima e mínima para estimar a ETo. Entretanto, essa equação requer um ajuste local. Esse estudo analisa a possibilidade de utilizar a equação de Hargreaves ajustada para estimar a ETo no estado de Goiás. Para isso, os parâmetros empíricos, HC (coeficiente empírico de Hargreaves e HE (expoente empírico de Hargreaves, da equação de Hargreaves foram ajustados considerando dois processos, ajuste local (HGR - Hargreaves ajuste local e ajuste regional (HGL - Hargreaves ajuste regional. Para o HGL, os parâmetros empíricos foram ajustados para cada estação meteorológica. Já, para o HGR, os parâmetros empíricos foram ajustados considerando conjuntamente os dados de todas as estações meteorológicas. A equação de Hargreaves ajustada para ambos os processos, local e regional, apresentou valores de ERQM de 17,95 e 21,93%, respectivamente, considerando o conjunto total de dados climáticos. A equação de Hargreaves ajustada localmente ou regionalmente é uma opção para estimar os valores diários de ETo no Estado de Goiás em locais em que a disponibilidade de dados climáticos é limitada.The FAO-56 Penman-Monteith equation (EToPM has been recommended by the Food and Agriculture Organization (FAO of the United Nations as the standard equation for estimating reference evapotranspiration (ETo. The FAO-56 PM equation requires numerous weather data that are not available in most of the stations of Brazil central. On the other hand, the Hargreaves equation is a more simple equation for

  11. Illuminant direction estimation for a single image based on local region complexity analysis and average gray value.

    Science.gov (United States)

    Yi, Jizheng; Mao, Xia; Chen, Lijiang; Xue, Yuli; Compare, Angelo

    2014-01-10

    Illuminant direction estimation is an important research issue in the field of image processing. Due to low cost for getting texture information from a single image, it is worthwhile to estimate illuminant direction by employing scenario texture information. This paper proposes a novel computation method to estimate illuminant direction on both color outdoor images and the extended Yale face database B. In our paper, the luminance component is separated from the resized YCbCr image and its edges are detected with the Canny edge detector. Then, we divide the binary edge image into 16 local regions and calculate the edge level percentage in each of them. Afterward, we use the edge level percentage to analyze the complexity of each local region included in the luminance component. Finally, according to the error function between the measured intensity and the calculated intensity, and the constraint function for an infinite light source model, we calculate the illuminant directions of the luminance component's three local regions, which meet the requirements of lower complexity and larger average gray value, and synthesize them as the final illuminant direction. Unlike previous works, the proposed method requires neither all of the information of the image nor the texture that is included in the training set. Experimental results show that the proposed method works better at the correct rate and execution time than the existing ones.

  12. Local-regional anesthesia in the management of stingray stings: Experience of the Bouffard medical-surgical hospital in Djibouti.

    Science.gov (United States)

    Vanoye, C; Lacroix, G; Le Gonidec, E; Couret, A; Benois, A; Peigne, V

    2017-02-01

    Stingray injuries are very painful. Systemic analgesics are ineffective, and the use of local-regional anesthesia has been reported. This retrospective descriptive study reviewed all cases of stingray injuries seen at the emergency department of the Bouffard Hospital (Djbouti, Africa) between 2011 and 2014. The study included 35 patients. Most of the injuries (n= 31, 89%) concerned the lower limbs. Median pain intensity was 6 [5-8] on a visual analog scale of 0 (no pain) to 10. The following systemic medications were administered: acetaminophen to 13 (27%) patients, morphine to 8 (23%), and tramadol to 6 (17%). In all, 25 (71%) patients received local-regional anesthesia, 15 (60%) by injections at the ankle. All procedures were successful, and no adverse event was reported. This study reports clinical data about stingray injuries in the Red Sea area and highlights the interest of local-regional anesthesia in their management. Most of the procedures were distal and could be performed by trained emergency physicians.

  13. Use of spatiotemporal characteristics of ambient PM2.5 in rural South India to infer local versus regional contributions.

    Science.gov (United States)

    Kumar, M Kishore; Sreekanth, V; Salmon, Maëlle; Tonne, Cathryn; Marshall, Julian D

    2018-05-08

    This study uses spatiotemporal patterns in ambient concentrations to infer the contribution of regional versus local sources. We collected 12 months of monitoring data for outdoor fine particulate matter (PM 2.5 ) in rural southern India. Rural India includes more than one-tenth of the global population and annually accounts for around half a million air pollution deaths, yet little is known about the relative contribution of local sources to outdoor air pollution. We measured 1-min averaged outdoor PM 2.5 concentrations during June 2015-May 2016 in three villages, which varied in population size, socioeconomic status, and type and usage of domestic fuel. The daily geometric-mean PM 2.5 concentration was ∼30 μg m -3 (geometric standard deviation: ∼1.5). Concentrations exceeded the Indian National Ambient Air Quality standards (60 μg m -3 ) during 2-5% of observation days. Average concentrations were ∼25 μg m -3 higher during winter than during monsoon and ∼8 μg m -3 higher during morning hours than the diurnal average. A moving average subtraction method based on 1-min average PM 2.5 concentrations indicated that local contributions (e.g., nearby biomass combustion, brick kilns) were greater in the most populated village, and that overall the majority of ambient PM 2.5 in our study was regional, implying that local air pollution control strategies alone may have limited influence on local ambient concentrations. We compared the relatively new moving average subtraction method against a more established approach. Both methods broadly agree on the relative contribution of local sources across the three sites. The moving average subtraction method has broad applicability across locations. Copyright © 2018 The Authors. Published by Elsevier Ltd.. All rights reserved.

  14. Sensitivity of extreme precipitation to temperature: the variability of scaling factors from a regional to local perspective

    Science.gov (United States)

    Schroeer, K.; Kirchengast, G.

    2018-06-01

    Potential increases in extreme rainfall induced hazards in a warming climate have motivated studies to link precipitation intensities to temperature. Increases exceeding the Clausius-Clapeyron (CC) rate of 6-7%/°C-1 are seen in short-duration, convective, high-percentile rainfall at mid latitudes, but the rates of change cease or revert at regionally variable threshold temperatures due to moisture limitations. It is unclear, however, what these findings mean in term of the actual risk of extreme precipitation on a regional to local scale. When conditioning precipitation intensities on local temperatures, key influences on the scaling relationship such as from the annual cycle and regional weather patterns need better understanding. Here we analyze these influences, using sub-hourly to daily precipitation data from a dense network of 189 stations in south-eastern Austria. We find that the temperature sensitivities in the mountainous western region are lower than in the eastern lowlands. This is due to the different weather patterns that cause extreme precipitation in these regions. Sub-hourly and hourly intensities intensify at super-CC and CC-rates, respectively, up to temperatures of about 17 °C. However, we also find that, because of the regional and seasonal variability of the precipitation intensities, a smaller scaling factor can imply a larger absolute change in intensity. Our insights underline that temperature precipitation scaling requires careful interpretation of the intent and setting of the study. When this is considered, conditional scaling factors can help to better understand which influences control the intensification of rainfall with temperature on a regional scale.

  15. Transport pathways and enhancement mechanisms within localized and non-localized transport regions in skin treated with low-frequency sonophoresis and sodium lauryl sulfate.

    Science.gov (United States)

    Polat, Baris E; Figueroa, Pedro L; Blankschtein, Daniel; Langer, Robert

    2011-02-01

    Recent advances in transdermal drug delivery utilizing low-frequency sonophoresis (LFS) and sodium lauryl sulfate (SLS) have revealed that skin permeability enhancement is not homogenous across the skin surface. Instead, highly perturbed skin regions, known as localized transport regions (LTRs), exist. Despite these findings, little research has been conducted to identify intrinsic properties and formation mechanisms of LTRs and the surrounding less-perturbed non-LTRs. By independently analyzing LTR, non-LTR, and total skin samples treated at multiple LFS frequencies, we found that the pore radii (r(pore)) within non-LTRs are frequency-independent, ranging from 18.2 to 18.5 Å, but significantly larger than r(pore) of native skin samples (13.6 Å). Conversely, r(pore) within LTRs increase significantly with decreasing frequency from 161 to 276 Å and to ∞ (>300 Å) for LFS/SLS-treated skin at 60, 40, and 20 kHz, respectively. Our findings suggest that different mechanisms contribute to skin permeability enhancement within each skin region. We propose that the enhancement mechanism within LTRs is the frequency-dependent process of cavitation-induced microjet collapse at the skin surface, whereas the increased r(pore) values in non-LTRs are likely due to SLS perturbation, with enhanced penetration of SLS into the skin resulting from the frequency-independent process of microstreaming. Copyright © 2010 Wiley-Liss, Inc.

  16. Transport Pathways and Enhancement Mechanisms within Localized and Non-Localized Transport Regions in Skin Treated with Low-Frequency Sonophoresis and Sodium Lauryl Sulfate

    Science.gov (United States)

    Polat, Baris E.; Figueroa, Pedro L.; Blankschtein, Daniel; Langer, Robert

    2011-01-01

    Recent advances in transdermal drug delivery utilizing low-frequency sonophoresis (LFS) and sodium lauryl sulfate (SLS) have revealed that skin permeability enhancement is not homogenous across the skin surface. Instead, highly perturbed skin regions, known as localized transport regions (LTRs), exist. Despite these findings, little research has been conducted to identify intrinsic properties and formation mechanisms of LTRs and the surrounding less-perturbed non-LTRs. By independently analyzing LTR, non-LTR, and total skin samples treated at multiple LFS frequencies, we found that the pore radii (rpore) within non-LTRs are frequency-independent, ranging from 18.2 – 18.5 Å, but significantly larger than rpore of native skin samples (13.6 Å). Conversely, rpore within LTRs increases significantly with decreasing frequency from 161 Å, to 276 Å, and to ∞ (>300Å) for LFS/SLS-treated skin at 60 kHz, 40 kHz, and 20 kHz, respectively. Our findings suggest that different mechanisms contribute to skin permeability enhancement within each skin region. We propose that the enhancement mechanism within LTRs is the frequency-dependent process of cavitation-induced microjet collapse at the skin surface, while the increased rpore values in non-LTRs are likely due to SLS perturbation, with enhanced penetration of SLS into the skin resulting from the frequency-independent process of microstreaming. PMID:20740667

  17. Relevance of PLUREL's results to policies at EU, national, regional and local level

    DEFF Research Database (Denmark)

    Fertner, Christian; Nielsen, Thomas Alexander Sick

    and results to policies and policy development at the EU-level, as well as the national and regional level. PLUREL has peri-urban land use relationships as its main focus. This includes analysis of drivers, consequences, policies and scenarios for the future. Even though PLUREL aims for pan-European coverage...... of natural resources as well as an attractive development in general. Besides these spatial relevant sector policies, the EU enforces legislation which is translated into spatial explicit instruments on sub-regional level. E.g. the Habitat and Birds Directive caused the development of Natura 2000 areas......, an EU-wide network of nature protection areas. The implementation of Trans-European Networks through funding programmes is another sector policy having an impact on land-use change and rural-urban relations. On the sub-regional scale the perception on overall goals like sustainability can be very...

  18. Engaging Local Communities in Arctic Observing Networks: A Collaborative Shoreline Change Risk WebGIS for Alaska's Arctic Slope Region

    Science.gov (United States)

    Brady, M.

    2017-12-01

    This study engaged local community stakeholders in Alaska's Arctic Slope Region to develop a web-based shoreline change risk geographic information system (WebGIS) in collaboration with the North Slope Borough and its residents. The value of the effort includes rich spatial documentation of local risks across the vast, remote, and rapidly changing shoreline, and identification of local manager information needs to direct WebGIS development. The study advances our understanding of shoreline change problems from the perspective of local Arctic communities beyond municipal impacts while building decision support. Over fifty local residents in three communities with collective coastal knowledge that extends across the National Petroleum Reserve - Alaska and Arctic National Wildlife Refuge shared their perspectives on hard copy maps. Sixteen managers provided usability perceptions of a beta WebGIS with shoreline change susceptibility information summarized at relevant asset locations such as subsistence camps. The hard copy maps with 300 "problem places" were digitized for analysis, which revealed problems across the coastline, especially challenges to boating for subsistence hunting such as shoaling cutting off access and creating hazards. The usability workshop revealed specific information needs including the need to monitor impacts at decommissioned national defense radar sites repurposed by locals to centralize oil and gas activity. These results were analyzed using an Instructional Systems Design (ISD) framework consisting of front-end and formative WebGIS evaluation phases. The front-end evaluation is the local input on hard copy maps, which provided local verification of coastal risks. The formative evaluation is the usability workshop with managers, which informed WebGIS development while promoting user buy-in. In terms of product and process, the local knowledge and information needs collected are significant because they establish local engagement with the

  19. Assessing marine biotechnology research centres in peripheral regions: developing global and local STI indicators

    Energy Technology Data Exchange (ETDEWEB)

    Robinson, D.K.R.; Schoen, A.; Laurens, P.; Horellou, S.; Colas, P.; Larédo, P.

    2016-07-01

    Our study tackles the challenge of developing STI indicators for assessing marine biotechnology (Blue Bio) research institutes that are geographically located in peripheral regions, far from major metropolitan areas. The promise of Blue Bio couples (a) the promise of new sources of knowledge and innovation with (b) the promise to stimulate jobs and growth in regions which struggle to prosper due to a number of factors (such as economic migration from peripheries to large cities, decline of traditional coastal economic activity etc.). In this paper we outline the context of Marine Biotechnology assessment, the framework that is being used, and the first results of its application. (Author)

  20. Estimation of local and regional components of drain - flow from an irrigated field

    International Nuclear Information System (INIS)

    Eching, S.O.; Hopmans, J.W.; Wallender, W.W.; Macyntyre, J.L.; Peters, D.

    1995-01-01

    The contribution of regional ground water and deep percolation from a furrow irrigated field to total drain flow was estimated using salt load analysis. It was found that 64% of the drain flow comes from regional ground water flow. The electrical conductivity of the drain water was highly correlated with the drain flow rate. From the field water balance with deep percolation as estimated from the salt load analysis, using yield function derived evapotranspiration, and measured changes in root zone water storage, it was shown that 14% of the crop evapotranspiration comes from ground water during the study period. 8 figs; 5 tabs; 15 refs ( Author )

  1. Partnering Students, Scientists, and the Local Community in a Regionally-focused Field Campaign

    Science.gov (United States)

    McLaughlin, J. W.; Lemone, M. A.; Seavey, M. M.; Washburne, J. C.

    2006-05-01

    The GLOBE Program (www.globe.gov) involves students and scientists in a worldwide environmental data collection effort. The GLOBE ONE field campaign (www.globe.gov/globeone) represents a model for a focused implementation of GLOBE via a geographically-specific project. The campaign, which occurred in Black Hawk County, Iowa from February 2004 to February 2006, was developed by GLOBE Principal Investigators (PIs), the GLOBE Program Office, and GLOBE Iowa. The central scientific objective was to compare quantitatively the environmental effects of various soil tillage techniques. In addition, student research projects were supported that spanned a variety of Earth science topics. The campaign established a partnership between students and scientists to collect a structured, multidisciplinary data set and also increase GLOBE visibility. The fact that GLOBE ONE occurred in a focused geographic area made it necessary to form a network for local support. This started with choosing an active GLOBE partner, namely the Iowa Academy of Science, who had the ability to oversee the local implementation of such a project. Once this partner was chosen, additional local groups needed to be recruited to support the project. The local network included K-12 schools, the County Conservation Board, the University of Northern Iowa, Hawkeye Community College, and community volunteers. This network collected data via automated instrumentation, first-hand observations, and through special events organized with a focus on a specific measurement. The first major step in supporting student research was a teacher training workshop held in March of 2006 that helped to provide tools for, and increase comfort levels with, promoting scientific inquiry in the classroom. Student-scientists interactions were promoted via scientist visits, video conferences, letters, and email exchanges. The culminating event was a Student Research Symposium held in February 2006 which gave students and scientists a

  2. Localization Strategies of the Czech Companies on the Basis of Industrial-logistics Parks in the Sverdlovsk Region

    Directory of Open Access Journals (Sweden)

    Plakhin Andrey

    2017-01-01

    Full Text Available The Czech Republic is traditionally a strategic partner of the Sverdlovsk region, the foreign trade turnover in 2015 exceeded $ 134 million. This circumstance makes it possible to formulate a scientific hypothesis on strengthening in the long term international economic relations between our countries and increasing the degree of mutual penetration of economic entities. One of the most probable scenarios can be assumed, on the one hand, to create joint ventures both in the Czech Republic and the Russian Federation, on the other, Czech companies will focus on the opportunities that modern industrial-logistics parks provide to localize their productions. Thus, the purpose of this study is to study the theoretical, methodological and applied aspects of the strategic location of Czech companies on the sites of industrial-logistics parks in the Sverdlovsk Region. The article analyses the potential for localization of Czech companies in the Sverdlovsk Region as a whole, identifies areas for possible strategic interaction across economic sectors, explores the parametric characteristics of the industrial-logistics parks in the Sverdlovsk region, presents their rating and assesses the level of competitiveness.

  3. Tree detection in urban regions from aerial imagery and DSM based on local maxima points

    Science.gov (United States)

    Korkmaz, Özgür; Yardımcı ćetin, Yasemin; Yilmaz, Erdal

    2017-05-01

    In this study, we propose an automatic approach for tree detection and classification in registered 3-band aerial images and associated digital surface models (DSM). The tree detection results can be used in 3D city modelling and urban planning. This problem is magnified when trees are in close proximity to each other or other objects such as rooftops in the scenes. This study presents a method for locating individual trees and estimation of crown size based on local maxima from DSM accompanied by color and texture information. For this purpose, segment level classifier trained for 10 classes and classification results are improved by analyzing the class probabilities of neighbour segments. Later, the tree classes under a certain height were eliminated using the Digital Terrain Model (DTM). For the tree classes, local maxima points are obtained and the tree radius estimate is made from the vertical and horizontal height profiles passing through these points. The final tree list containing the centers and radius of the trees is obtained by selecting from the list of tree candidates according to the overlapping and selection parameters. Although the limited number of train sets are used in this study, tree classification and localization results are competitive.

  4. The Third American Society of Regional Anesthesia and Pain Medicine Practice Advisory on Local Anesthetic Systemic Toxicity: Executive Summary 2017.

    Science.gov (United States)

    Neal, Joseph M; Barrington, Michael J; Fettiplace, Michael R; Gitman, Marina; Memtsoudis, Stavros G; Mörwald, Eva E; Rubin, Daniel S; Weinberg, Guy

    2018-02-01

    The American Society of Regional Anesthesia and Pain Medicine's Third Practice Advisory on local anesthetic systemic toxicity is an interim update from its 2010 advisory. The advisory focuses on new information regarding the mechanisms of lipid resuscitation, updated frequency estimates, the preventative role of ultrasound guidance, changes to case presentation patterns, and limited information related to local infiltration anesthesia and liposomal bupivacaine. In addition to emerging information, the advisory updates recommendations pertaining to prevention, recognition, and treatment of local anesthetic systemic toxicity. WHAT'S NEW IN THIS UPDATE?: This interim update summarizes recent scientific findings that have enhanced our understanding of the mechanisms that lead to lipid emulsion reversal of LAST, including rapid partitioning, direct inotropy, and post-conditioning. Since the previous practice advisory, epidemiological data have emerged that suggest a lower frequency of LAST as reported by single institutions and some registries, nevertheless a considerable number of events still occur within the general community. Contemporary case reports suggest a trend toward delayed presentation, which may mirror the increased use of ultrasound guidance (fewer intravascular injections), local infiltration techniques (slower systemic uptake), and continuous local anesthetic infusions. Small patient size and sarcopenia are additional factors that increase potential risk for LAST. An increasing number of reported events occur outside of the traditional hospital setting and involve non-anesthesiologists.

  5. Violence and displacement: Towards a regional and local interpretation. The case of Risaralda and its capital Pereira

    Directory of Open Access Journals (Sweden)

    Luis Adolfo Martínez Herrera

    2006-07-01

    Full Text Available This dissertation tries to make an analysis about phenomenons of violence in the region of Risaralda and your capital Pereira. The established reflection is made by means of a historical view, a violence characterization and some of your causal explanations, a reflection where the main reference is the territory and your manifold scenes that conjugate actors crossing, interests and territorial dominions, besides, a migratory process by violence (displacement by violence that materializes the sequels of conflict, and finally, by means of a local view that recognizes in the globalized societies, new non regulated scenes of conflict by the state-nation. This analysis permits to recognize the territorial topics of control and dominion and it identifies some of the structural explanations that show continuities and discontinuities that have an effect on population of the region in a differentiated way. The reflection provokes new questions to guide next investigations in the region.

  6. A multicriteria framework for producing local, regional, and national insect and disease risk maps

    Science.gov (United States)

    Frank J. Jr. Krist; Frank J. Sapio

    2010-01-01

    The construction of the 2006 National Insect and Disease Risk Map, compiled by the USDA Forest Service, State and Private Forestry Area, Forest Health Protection Unit, resulted in the development of a GIS-based, multicriteria approach for insect and disease risk mapping that can account for regional variations in forest health concerns and threats. This risk mapping...

  7. Regions of variability for a class of analytic and locally univalent ...

    Indian Academy of Sciences (India)

    f ′′(0) whenever f varies over the class C(A,B). Keywords. Janowski class; univalent functions; variability regions. 2000 Mathematics Subject Classification. 30C45. 1. Introduction and preliminary results. Let C be the complex plane. We use the following notations for open and closed discs with center c and radius r in the ...

  8. Adjusting the Stems Regional Forest Growth Model to Improve Local Predictions

    Science.gov (United States)

    W. Brad Smith

    1983-01-01

    A simple procedure using double sampling is described for adjusting growth in the STEMS regional forest growth model to compensate for subregional variations. Predictive accuracy of the STEMS model (a distance-independent, individual tree growth model for Lake States forests) was improved by using this procedure

  9. Monitoring the transformation of historic features in Antarctica and Svalbard : local processes and regional contexts

    NARCIS (Netherlands)

    Roura, Ricardo

    2010-01-01

    Historical sites in Antarctica and Svalbard contain the material remains of past activities of exploration and exploitation of these regions. These sites have been subject to transformation by cultural and non-cultural (natural) processes since their abandonment to the present. For research and

  10. 75 FR 55274 - Change of Address for Region 5 State and Local Agencies; Technical Correction

    Science.gov (United States)

    2010-09-10

    ... Lafayette Road North, St. Paul, Minnesota 55155, rather than to EPA's Region 5 office. Subpart KK--Ohio 0 6..., Division of Air Quality, 520 Lafayette Road North, St. Paul, Minnesota 55155. * * * * * (KK) State of Ohio..., Logan, OH 43138. (xi) Champaign, Clinton, Highland, Logan, and Shelby Counties; Ohio Environmental...

  11. Sensory analysis as a tool to compare imported and local meat in outermost regions of Europe

    DEFF Research Database (Denmark)

    Hernandez Castellano, Lorenzo E; Morales-delaNuez, Antonio; Moreno-Indias, Isabel

    2013-01-01

    , therefore, was to evaluate sensorial differences between IM and LM using the Canary Islands as an example of an outermost region of Europe. Two kinds of sensory analyses were performed: a triangular test with 31 untrained consumers and a descriptive test with a trained 12-member tasting panel...

  12. Local climate change capacity : comparing four municipalities in the Dutch Twente region

    NARCIS (Netherlands)

    van der Vegt, Arjen; Hoppe, Thomas; Stegmaier, Peter

    2015-01-01

    Climate change is seen as a key societal challenge to cities and regions. City governments design and implement policies to cope with climate change: on the one hand by mitigating greenhouse gas emissions and spurring low carbon transition; on the other hand by adapting to climate change, hence

  13. Structure of the protein core of the glypican Dally-like and localization of a region important for hedgehog signaling

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Min-Sung; Saunders, Adam M.; Hamaoka, Brent Y.; Beachy, Philip A.; Leahy, Daniel J. (Stanford-MED); (JHU)

    2011-09-20

    Glypicans are heparan sulfate proteoglycans that modulate the signaling of multiple growth factors active during animal development, and loss of glypican function is associated with widespread developmental abnormalities. Glypicans consist of a conserved, approximately 45-kDa N-terminal protein core region followed by a stalk region that is tethered to the cell membrane by a glycosyl-phosphatidylinositol anchor. The stalk regions are predicted to be random coil but contain a variable number of attachment sites for heparan sulfate chains. Both the N-terminal protein core and the heparan sulfate attachments are important for glypican function. We report here the 2.4-{angstrom} crystal structure of the N-terminal protein core region of the Drosophila glypican Dally-like (Dlp). This structure reveals an elongated, {alpha}-helical fold for glypican core regions that does not appear homologous to any known structure. The Dlp core protein is required for normal responsiveness to Hedgehog (Hh) signals, and we identify a localized region on the Dlp surface important for mediating its function in Hh signaling. Purified Dlp protein core does not, however, interact appreciably with either Hh or an Hh:Ihog complex.

  14. [Regression and therapy-resistance of primary liver tumors and liver metastases after regional chemotherapy and local tumor ablation].

    Science.gov (United States)

    Fischer, H-P

    2005-05-01

    High dosage regional chemotherapy, chemoembolization and other methods of regional treatment are commonly used to treat unresectable primary liver malignancies and liver metastases. In liver malignancies of childhood neoadjuvant chemotherapy is successfully combined with surgical treatment. Chemotherapy and local tumor ablation lead to characteristic histomorphologic changes: Complete destruction of the tumor tissue and its vascular bed is followed by encapsulated necroses. After selective eradication of the tumor cells under preservation of the fibrovasular bed the tumor is replaced by hypocellular edematous and fibrotic tissue. If completely damaged tumor tissue is absorbed quickly, the tumor area is replaced by regenerating liver tissue. Obliterating fibrohyalinosis of tumor vessels, and perivascular edema or necrosis indicate tissue damage along the vascular bed. Degenerative pleomorphism of tumor cells, steatosis, hydropic swelling and Malloryhyalin in HCC can represent cytologic findings of cytotoxic cellular damage. Macroscopic type of HCC influences significantly the response to treatment. Multinodular HCC often contain viable tumor nodules close to destroyed nodules after treatment. Encapsulated uninodular tumors undergo complete necrosis much easier. Large size and a tumor capsule limitate the effect of percutaneous injection of ethanol into HCC. In carcinomas with an infiltrating border, especially in metastases of adenocarcinomas and hepatic cholangiocarcinoma cytostatic treatment damages the tumor tissue mainly in the periphery. Nevertheless the infiltrating rim, portal veins, lymphatic spaces and bile ducts as well as the angle between liver capsule, tumor nodule and bordering parenchyma are the main refugees of viable tumor tissue even after high dosage regional chemotherapy. This local resistance is caused by special local conditions of vascularization and perfusion. These residues are the source of local tumor progression and distant metastases

  15. Kinetic-freezing and unfreezing of local-region fluctuations in a glass structure observed by heat capacity hysteresis

    Energy Technology Data Exchange (ETDEWEB)

    Aji, D. P. B.; Johari, G. P., E-mail: joharig@mcmaster.ca [Department of Materials Science and Engineering, McMaster University, Hamilton, Ontario L8S 4L7 (Canada)

    2015-06-07

    Fluctuations confined to local regions in the structure of a glass are observed as the Johari-Goldstein (JG) relaxation. Properties of these regions and their atomic configuration are currently studied by relaxation techniques, by electron microscopy, and by high-energy X-ray scattering and extended x-ray absorption fine structure methods. One expects that these fluctuations (i) would kinetically freeze on cooling a glass, and the temperature coefficient of its enthalpy, dH/dT, would consequently show a gradual decrease with decrease in T, (ii) would kinetically unfreeze on heating the glass toward the glass-liquid transition temperature, T{sub g}, and dH/dT would gradually increase, and (iii) there would be a thermal hysteresis indicating the time and temperature dependence of the enthalpy. Since no such features have been found, thermodynamic consequences of these fluctuations are debated. After searching for these features in glasses of different types, we found it in one of the most stable metal alloy glasses of composition Pd{sub 40}Ni{sub 10}Cu{sub 30}P{sub 20}. On cooling from its T{sub g}, dH/dT decreased along a broad sigmoid-shape path as local-region fluctuations kinetically froze. On heating thereafter, dH/dT increased along a similar path as these fluctuations unfroze, and there is hysteresis in the cooling and heating paths, similar to that observed in the T{sub g}-endotherm range. After eliminating other interpretations, we conclude that local-region fluctuations seen as the JG relaxation in the non-equilibrium state of a glass contribute to its entropy, and we suggest conditions under which such fluctuations may be observed.

  16. Kinetic-freezing and unfreezing of local-region fluctuations in a glass structure observed by heat capacity hysteresis

    International Nuclear Information System (INIS)

    Aji, D. P. B.; Johari, G. P.

    2015-01-01

    Fluctuations confined to local regions in the structure of a glass are observed as the Johari-Goldstein (JG) relaxation. Properties of these regions and their atomic configuration are currently studied by relaxation techniques, by electron microscopy, and by high-energy X-ray scattering and extended x-ray absorption fine structure methods. One expects that these fluctuations (i) would kinetically freeze on cooling a glass, and the temperature coefficient of its enthalpy, dH/dT, would consequently show a gradual decrease with decrease in T, (ii) would kinetically unfreeze on heating the glass toward the glass-liquid transition temperature, T g , and dH/dT would gradually increase, and (iii) there would be a thermal hysteresis indicating the time and temperature dependence of the enthalpy. Since no such features have been found, thermodynamic consequences of these fluctuations are debated. After searching for these features in glasses of different types, we found it in one of the most stable metal alloy glasses of composition Pd 40 Ni 10 Cu 30 P 20 . On cooling from its T g , dH/dT decreased along a broad sigmoid-shape path as local-region fluctuations kinetically froze. On heating thereafter, dH/dT increased along a similar path as these fluctuations unfroze, and there is hysteresis in the cooling and heating paths, similar to that observed in the T g -endotherm range. After eliminating other interpretations, we conclude that local-region fluctuations seen as the JG relaxation in the non-equilibrium state of a glass contribute to its entropy, and we suggest conditions under which such fluctuations may be observed

  17. Constraints on the crustal structure beneath the Sinai subplate, SE Mediterranean, from analysis of local and regional travel times

    Directory of Open Access Journals (Sweden)

    Mohamed K. Salah

    2013-03-01

    Full Text Available The Sinai Peninsula has been recognized as a subplate of the African Plate located at the triple junction of the Gulf of Suez rift, the Dead Sea Transform fault, and the Red Sea rift. The upper and lower crustal structures of this tectonically active, rapidly developing region are yet poorly understood because of many limitations. For this reason, a set of P- and S-wave travel times recorded at 14 seismic stations belonging to the Egyptian National Seismographic Network (ENSN from 111 local and regional events are analyzed to investigate the crustal structures and the locations of the seismogenic zones beneath central and southern Sinai. Because the velocity model used for routine earthquake location by ENSN is one-dimensional, the travel-time residuals will show lateral heterogeneity of the velocity structures and unmodeled vertical structures. Seismic activity is strong along the eastern and southern borders of the study area but low to moderate along the northern boundary and the Gulf of Suez to the west. The crustal Vp/Vs ratio is 1.74 from shallow (depth ≤ 10 km earthquakes and 1.76 from deeper (depth > 10 km crustal events. The majority of the regional and local travel-time residuals are positive relative to the Preliminary Reference Earth Model (PREM, implying that the seismic stations are located above widely distributed, tectonically-induced low-velocity zones. These low-velocity zones are mostly related to the local crustal faults affecting the sedimentary section and the basement complex as well as the rifting processes prevailing in the northern Red Sea region and the ascending of hot mantle materials along crustal fractures. The delineation of these low-velocity zones and the locations of big crustal earthquakes enable the identification of areas prone to intense seismotectonic activities, which should be excluded from major future development projects and large constructions in central and southern Sinai.

  18. Gender asymmetry in local authorities: in the case of Dnipropetrovsk region

    Directory of Open Access Journals (Sweden)

    A. V. Skrypnyk

    2017-07-01

    In the course of the author’s sociological research, workers of local authorities of the above mentioned cities were interviewed. Thus, the real situation of gender assimilation, the attitude of this group to the gender policy of our state has been identified. The main pain points of gender asymmetry have been found and thus, the main development prospects, what problems must be addressed first and, most importantly, to what ideal the Ukrainian society should strive for in conditions of gender asymmetry have been described.

  19. Competitiveness as a function of local and regional growth and development

    Directory of Open Access Journals (Sweden)

    Ivana Bestvina Bukvić

    2014-12-01

    Full Text Available Each economic entity, institution and individual has the responsibility of contributing to the economic development in its region. Creating conditions for the development and empowerment of the business sector are activities that in the long run lead to the strengthening of not only certain economic sectors, but the entire region. In the recent period sources from EU funds for co-financing of capital projects have become available to investors. Given the uncertainty in business conditions, investors’ poor capitalization, lack of business profitability and, in terms of profitability and risk, lack of high-quality capital projects, the benefits of these resources are insufficient and/or inadequately used. The aim of this paper is to analyse the strength and capabilities of Croatian companies for financing and implementation of high-quality capital projects. For this purpose, this paper will present the results of research of financial position of selected companies in 2012. Also, it presents the results of research from 2011 that examined the reality of projections of later activated investment projects. These results are the basis for a conclusion about the ability of management, in the analysed region, to make realistic plans and carry out high-quality capital projects.

  20. ANALYSIS IMPACT OF THE EXPANSION OF THE REGION AGAINST LOCAL COMMUNITY SOCIAL CONFLICT

    Directory of Open Access Journals (Sweden)

    Baso Madiong

    2016-11-01

    Full Text Available Research entitled the influence of the expansion Area of the cultural values of society of West Sulawesi province aims to study the formation mechanism of the new autonomous region, as well as more healt not neglecting the terms that have been determined. and that is not less important is the readiness of the region concerned, both in aspects of the financing, human Resources and the credibility of the bureaucracy in the management of good governance and better. the other thing is to do the capacity of the public to control the performance of the Executive and the legislature which is especially representative of the people who tend to exploit the people. so that the spirit of the sea area bottom line is improving public services and rich people and does not pose a conflict of cultures really manifested in a more benevolent and wise. The method used is the guidance to the Government and society in General about the real purpose of the expansion area as well as coaching the community who are in conflict due to the expansion region.

  1. COROTATING INTERACTION REGION ASSOCIATED SUPRATHERMAL HELIUM ION ENHANCEMENTS AT 1 AU: EVIDENCE FOR LOCAL ACCELERATION AT THE COMPRESSION REGION TRAILING EDGE

    International Nuclear Information System (INIS)

    Ebert, R. W.; Dayeh, M. A.; Desai, M. I.; Mason, G. M.

    2012-01-01

    We examined the temporal profiles and peak intensities for 73 corotating interaction region (CIR)-associated suprathermal (∼0.1-8 MeV nucleon –1 ) helium (He) ion enhancements identified at STEREO-A, STEREO-B, and/or Advanced Composition Explorer between 2007 and 2010. We found that in most events the peak He intensity times were well organized by the CIR compression region trailing edge, regardless of whether or not a reverse shock was present. Out of these events, 19% had their 0.193 MeV nucleon –1 He intensities peak within 1 hr and 50% within 4.75 hr of the CIR trailing edge, the distribution having a 1σ value of 7.3 hr. Events with a 0.193 MeV nucleon –1 He intensity peak time within 1σ of the CIR trailing edge showed a positive correlation between the ∼0.1 and 0.8 MeV nucleon –1 He peak intensities and magnetic compression ratios in events both with and without a reverse shock. The peak intensities in all other events showed little to moderate correlation between these parameters. Our results provide evidence that some fraction of the CIR-associated –1 He intensity enhancements observed at 1 AU are locally driven. We suggest an extended source for the CIR-associated energetic particles observed at 1 AU where the –1 ions are accelerated locally at or near the CIR trailing edge, the intensities being proportional to the local compression ratio strength, while the >MeV particles are likely accelerated at CIR-driven shocks beyond Earth orbit.

  2. Evaluating the ability of regional models to predict local avian abundance

    Science.gov (United States)

    LeBrun, Jaymi J.; Thogmartin, Wayne E.; Miller, James R.

    2012-01-01

    Spatial modeling over broad scales can potentially direct conservation efforts to areas with high species-specific abundances. We examined the performance of regional models for predicting bird abundance at spatial scales typically addressed in conservation planning. Specifically, we used point count data on wood thrush (Hylocichla mustelina) and blue-winged warbler (Vermivora cyanoptera) from 2 time periods (1995-1998 and 2006-2007) to evaluate the ability of regional models derived via Bayesian hierarchical techniques to predict bird abundance. We developed models for each species within Bird Conservation Region (BCR) 23 in the upper midwestern United States at 800-ha, 8,000-ha, and approximately 80,000-ha scales. We obtained count data from the Breeding Bird Survey and land cover data from the National Land Cover Dataset (1992). We evaluated predictions from the best models, as defined by an information-theoretic criterion, using point count data collected within an ecological subregion of BCR 23 at 131 count stations in the 1990s and again in 2006-2007. Competing (Deviance Information Criteria rs = 0.57; P = 0.14), the survey period that most closely aligned with the time period of data used for regional model construction. Wood thrush models exhibited positive correlations with point count data for all survey areas and years combined (rs = 0.58, P ≤ 0.001). In comparison, blue-winged warbler models performed worse as time increased between the point count surveys and vintage of the model building data (rs = 0.03, P = 0.92 for Iowa and rs = 0.13, P = 0.51 for all areas, 2006-2007), likely related to the ephemeral nature of their preferred early successional habitat. Species abundance and sensitivity to changing habitat conditions seems to be an important factor in determining the predictive ability of regional models. Hierarchical models can be a useful tool for concentrating efforts at the scale of management units and should be one of many tools used by

  3. Identification of critical regions in human SAMHD1 required for nuclear localization and Vpx-mediated degradation.

    Science.gov (United States)

    Guo, Haoran; Wei, Wei; Wei, Zhenhong; Liu, Xianjun; Evans, Sean L; Yang, Weiming; Wang, Hong; Guo, Ying; Zhao, Ke; Zhou, Jian-Ying; Yu, Xiao-Fang

    2013-01-01

    The sterile alpha motif (SAM) and HD domain-containing protein-1 (SAMHD1) inhibits the infection of resting CD4+ T cells and myeloid cells by human and related simian immunodeficiency viruses (HIV and SIV). Vpx inactivates SAMHD1 by promoting its proteasome-dependent degradation through an interaction with CRL4 (DCAF1) E3 ubiquitin ligase and the C-terminal region of SAMHD1. However, the determinants in SAMHD1 that are required for Vpx-mediated degradation have not been well characterized. SAMHD1 contains a classical nuclear localization signal (NLS), and NLS point mutants are cytoplasmic and resistant to Vpx-mediated degradation. Here, we demonstrate that NLS-mutant SAMHD1 K11A can be rescued by wild-type SAMHD1, restoring its nuclear localization; consequently, SAMHD1 K11A became sensitive to Vpx-mediated degradation in the presence of wild-type SAMHD1. Surprisingly, deletion of N-terminal regions of SAMHD1, including the classical NLS, generated mutant SAMHD1 proteins that were again sensitive to Vpx-mediated degradation. Unlike SAMHD1 K11A, these deletion mutants could be detected in the nucleus. Interestingly, NLS-defective SAMHD1 could still bind to karyopherin-β1 and other nuclear proteins. We also determined that the linker region between the SAM and HD domain and the HD domain itself is important for Vpx-mediated degradation but not Vpx interaction. Thus, SAMHD1 contains an additional nuclear targeting mechanism in addition to the classical NLS. Our data indicate that multiple regions in SAMHD1 are critical for Vpx-mediated nuclear degradation and that association with Vpx is not sufficient for Vpx-mediated degradation of SAMHD1. Since the linker region and HD domain may be involved in SAMHD1 multimerization, our results suggest that SAMHD1 multimerization may be required for Vpx-mediation degradation.

  4. Second status report on regional and local ground-water flow modeling for Richton and Cypress Creek Domes, Mississippi

    International Nuclear Information System (INIS)

    1986-08-01

    Regional and local ground-water flow within the principal geohydrologic units in the Mississippi salt-dome basin is evaluated by developing conceptual models of the flow regime at a regional and a local scale and testing these models using a three-dimensional, finite-difference flow code. Semiquantitative sensitivity analyses (a limited parametric study) are conducted to define the system response to changes in the conceptual models. The conceptual models are described in terms of their areal and vertical discretizations, aquifer properties, fluid properties, and hydrologic boundary conditions. The simulated ground-water flow fields are described with potentiometric surfaces, areas of upward and downward flow across aquitards, tables summarizing the real and vertical volumetric flows through the principal units, and Darcy velocities with specified finite-difference blocks. Ground-water travel paths and times from both Richton Dome and Cypress Creek Dome are provided. The regional scale simulation results are discussed with regard to measured field data. The reported work is the second state of an ongoing evaluation of Richton and Cypress Creek Domes as potential repositories for high-level radioactive wastes. The results and conclusions should thus be considered preliminary and subject to modification with the collection of additional data. However, the report does provide a useful basis for describing the sensitivity of the present conceptualization of ground-water flow to parameterization and, to a lesser extent, the uncertainties in the present conceptualization. 19 refs., 33 figs., 25 tabs

  5. Building a regional health equity movement: the grantmaking model of a local health department.

    Science.gov (United States)

    Baril, Nashira; Patterson, Meghan; Boen, Courtney; Gowler, Rebekah; Norman, Nancy

    2011-01-01

    The Boston Public Health Commission's Center for Health Equity and Social Justice provides grant funding, training, and technical assistance to 15 organizations and coalitions across New England to develop, implement, and evaluate community-based policy and systems change strategies that address social determinants of health and reduce racial and ethnic health inequities. This article describes Boston Public Health Commission's health equity framework, theory of change regarding the elimination of racial and ethnic health inequities, and current grantmaking model. To conclude, the authors evaluate the grant model and offer lessons learned from providing multiyear regional grants to promote health equity.

  6. Characterizing and Quantifying Local and Regional Particulate Matter Emissions from Department of Defense Installations

    Science.gov (United States)

    2005-03-01

    region (Fig. 4.1). A summary of the annual and seasonal average temperature, precipitation , and wind conditions for El Paso is presented in Table 4.1... Precipitation (cm) 2 Average Wind Speed 2 (km/hr) Prevailing Wind Direction 2 (degrees) Annual 17.3 22.4 14.2 360 Winter (Dec...Chow, 2001; Chow et al., 2003). The Teflon-membrane filters were analyzed for mass by gravimetry using a Cahn 31 Electro-microbalance and for 40

  7. Finnish experiences of health monitoring: local, regional, and national data sources for policy evaluation

    Directory of Open Access Journals (Sweden)

    Katri Kilpeläinen

    2016-02-01

    Full Text Available Background: Finland has a long tradition of gathering information about the health and welfare of the adult population. Design: Surveys and administrative registers form the basis for national and local health monitoring in Finland. Results: Different data sources are used in Finland to develop key indicators, which can be used to evaluate how the national health policy targets have been met in different parts of the country and in different population subgroups. Progress has been shown in chronic disease risk factors, such as smoking reduction. However, some health policy targets have not been met. Socioeconomic health differences, for example, have remained large compared with other European countries. Conclusion: Although data availability for key health indicators is good in Finland, there is a need for wider and more comprehensive use of this information by political decision-makers and healthcare professionals.

  8. Time dependency of local cerebral blood flow measurements caused by regional variations in tissue transit time

    International Nuclear Information System (INIS)

    Lear, J.L.; Kasliwal, R.; Feyerabend, A.

    1990-01-01

    Calculated values of local cerebral blood flow (LCBF) using the diffusible tracer model are assumed to be independent of time as long as experiments are brief enough to prevent tissue saturation. This paper investigates the effects of CTT variation on LCBF measurements. Using double-label quantitative digital autoradiography, we compared iodoantipyrine (IAP)-based LCBF measurements obtained with tracer infusions of different lengths of time. Lightly anesthetized rats were given simultaneous ramp infusions of C-14 IAP (45 seconds) and I-123 IAP (15 seconds) and immediately sacrificed. Two autoradiograms of each brain section, one representing I-123 and the other representing C-14, were produced, digitized, and converted into images of LCBF based on the 15- and 45-second infusion periods. The LCBF image pairs were compared on a pixel-by-pixel basis

  9. On waves below the local proton gyrofrequency in auroral acceleration regions

    International Nuclear Information System (INIS)

    Gustafsson, G.; Andre, M.; Matson, L.; Koskinen, H.

    1990-01-01

    The Viking wave electric field and density fluctuation measurements together with simultaneous particle observations are used to study waves at frequencies below the local proton gyrofrequency. Such waves were observed during about 20% of nightside auroral field line crossings by Viking at altitudes between 2,000 and 10,000 km. The observations are different from earlier spacecraft observations of similar waves in such a way that the center frequency in about one out of four of the observed events was below the gyrofrequency of singly charged helium, which has not been reported previously. The waves were well correlated with precipitating electrons of energies of a few keV and with VLF auroral hiss. Detailed investigations of simultaneously observed wave emissions, particles, and total densities strongly suggest that secondary peaks at keV energies in the distributions of downgoing electrons can cause the emissions

  10. Stochastic characterization of regional circulation patterns for climate model diagnosis and estimation of local precipitation

    International Nuclear Information System (INIS)

    Zorita, E.; Hughes, J.P.

    1993-01-01

    Two statistical approaches for linking large-scale atmospheric circulation patterns and daily local rainfall are described and applied to several GCM (general circulation model) climate simulations. The ultimate objective is to simulate local precipitation associated with alternative climates. The index stations are located near the West and East North American coasts. The first method is based on CART analysis (Classification and Regression trees). It finds the classification of observed daily SLR (sea level pressure) fields in weather types that are most strongly associated with the presence/absence of rainfall in a set of index stations. The best results were obtained for winter rainfall for the West Coast, where a set of physically reasonable weather types could be identified, whereas for the East Coast the rainfall process seemed to be spatially less coherent. The GCM simulations were validated against observations in terms of probability of occurrence and survival time of these weather states. Some discrepancies werefound but there was no systematic bias, indicating that this behavior depends on the particular dynamics of each model. This classification method was then used for the generation of daily rainfall time series from the daily SLP fields from historical observation and from the GCM simulations. Whereas the mean rainfall and probability distributions were rather well replicated, the simulated dry periods were in all cases shorter than in the rainfall observations. The second rainfall generator is based on the analog method and uses information on the evolution of the SLP field in several previous days. It was found to perform reasonably well, although some downward bias in the simulated rainfall persistence was still present. Rainfall changes in a 2xCO 2 climate were investigated by applying both methods to the output of a greenhouse-gas experiment. The simulated precipitation changes were small. (orig.)

  11. Thermal Heat and Power Production with Models for Local and Regional Energy Systems

    Energy Technology Data Exchange (ETDEWEB)

    Saether, Sturla

    1999-07-01

    The primary goal of this thesis is the description and modelling of combined heat and power systems as well as analyses of thermal dominated systems related to benefits of power exchange. Large power plants with high power efficiency (natural gas systems) and heat production in local heat pumps can be favourable in areas with low infrastructure of district heating systems. This system is comparable with typical combined heat and power (CHP) systems based on natural gas with respect to efficient use of fuel energy. The power efficiency obtainable from biomass and municipal waste is relatively low and the advantage of CHP for this system is high compared to pure power production with local heat pumps for heat generation. The advantage of converting pure power systems into CHP systems is best for power systems with low power efficiency and heat production at low temperature. CHP systems are divided into two main groups according to the coupling of heat and power production. Some CHP systems, especially those with strong coupling between heat and power production, may profit from having a thermal heat storage subsystem. District heating temperatures direct the heat to power ratio of the CHP units. The use of absorption chillers driven by district heating systems are also evaluated with respect to enhancing the utilisation of district heating in periods of low heat demand. Power exchange between a thermal dominated and hydropower system is found beneficial. Use of hydropower as a substitute for peak power production in thermal dominated systems is advantageous. Return of base load from the thermal dominated system to the hydropower system can balance in the net power exchange.

  12. Local and regional effects on community structure of dung beetles in a mainland-island scenario.

    Directory of Open Access Journals (Sweden)

    Pedro Giovâni da Silva

    Full Text Available Understanding the ecological mechanisms driving beta diversity is a major goal of community ecology. Metacommunity theory brings new ways of thinking about the structure of local communities, including processes occurring at different spatial scales. In addition to new theories, new methods have been developed which allow the partitioning of individual and shared contributions of environmental and spatial effects, as well as identification of species and sites that have importance in the generation of beta diversity along ecological gradients. We analyzed the spatial distribution of dung beetle communities in areas of Atlantic Forest in a mainland-island scenario in southern Brazil, with the objective of identifying the mechanisms driving composition, abundance and biomass at three spatial scales (mainland-island, areas and sites. We sampled 20 sites across four large areas, two on the mainland and two on the island. The distribution of our sampling sites was hierarchical and areas are isolated. We used standardized protocols to assess environmental heterogeneity and sample dung beetles. We used spatial eigenfunctions analysis to generate the spatial patterns of sampling points. Environmental heterogeneity showed strong variation among sites and a mild increase with increasing spatial scale. The analysis of diversity partitioning showed an increase in beta diversity with increasing spatial scale. Variation partitioning based on environmental and spatial variables suggests that environmental heterogeneity is the most important driver of beta diversity at the local scale. The spatial effects were significant only at larger spatial scales. Our study presents a case where environmental heterogeneity seems to be the main factor structuring communities at smaller scales, while spatial effects are more important at larger scales. The increase in beta diversity that occurs at larger scales seems to be the result of limitation in species dispersal

  13. The N-terminal region of eukaryotic translation initiation factor 5A signals to nuclear localization of the protein

    International Nuclear Information System (INIS)

    Parreiras-e-Silva, Lucas T.; Gomes, Marcelo D.; Oliveira, Eduardo B.; Costa-Neto, Claudio M.

    2007-01-01

    The eukaryotic translation initiation factor 5A (eIF5A) is a ubiquitous protein of eukaryotic and archaeal organisms which undergoes hypusination, a unique post-translational modification. We have generated a polyclonal antibody against murine eIF5A, which in immunocytochemical assays in B16-F10 cells revealed that the endogenous protein is preferentially localized to the nuclear region. We therefore analyzed possible structural features present in eIF5A proteins that could be responsible for that characteristic. Multiple sequence alignment analysis of eIF5A proteins from different eukaryotic and archaeal organisms showed that the former sequences have an extended N-terminal segment. We have then performed in silico prediction analyses and constructed different truncated forms of murine eIF5A to verify any possible role that the N-terminal extension might have in determining the subcellular localization of the eIF5A in eukaryotic organisms. Our results indicate that the N-terminal extension of the eukaryotic eIF5A contributes in signaling this protein to nuclear localization, despite of bearing no structural similarity with classical nuclear localization signals

  14. Response of SO2 and Particulate Air Pollution to Local and Regional Emission Controls: A Case Study in Maryland

    Science.gov (United States)

    He, Hao; Vinnikov, Konstantin Y.; Li, Can; Krotkov, Nickolay Anatoly; Jongeward, Andrew R.; Li, Zhanqing; Stehr, Jeffrey W.; Hains, Jennifer; Dickerson, RUssell R.

    2016-01-01

    This paper addresses the questions of what effect local regulations can have on pollutants with different lifetimes and how surface observations and remotely sensed data can be used to determine the impacts. We investigated the decadal trends of tropospheric sulfur dioxide (SO2) and aerosol pollution over Maryland and its surrounding states, using surface, aircraft, and satellite measurements. Aircraft measurements indicated fewer isolated SO2 plumes observed in summers, a 40 decrease of column SO2, and a 20 decrease of atmospheric optical depth (AOD) over Maryland after the implementation of local regulations on sulfur emissions from power plants (90 reduction from 2010). Surface observations of SO2 and particulate matter (PM) concentrations in Maryland show similar trends. OMI SO2 and MODIS AOD observations were used to investigate the column contents of air pollutants over the eastern U.S.; these indicate decreasing trends in column SO2 (60 decrease) and AOD (20 decrease). The decrease of upwind SO2 emissions also reduced aerosol loadings over the downwind Atlantic Ocean near the coast by 20, while indiscernible changes of the SO2 column were observed. A step change of SO2 emissions in Maryland starting in 20092010 had an immediate and profound benefit in terms of local surface SO2 concentrations but a modest impact on aerosol pollution, indicating that short-lived pollutants are effectively controlled locally, while long-lived pollutants require regional measures.

  15. Mutations in the C-terminal region affect subcellular localization of crucian carp herpesvirus (CaHV) GPCR.

    Science.gov (United States)

    Wang, Jun; Gui, Lang; Chen, Zong-Yan; Zhang, Qi-Ya

    2016-08-01

    G protein-coupled receptors (GPCRs) are known as seven transmembrane domain receptors and consequently can mediate diverse biological functions via regulation of their subcellular localization. Crucian carp herpesvirus (CaHV) was recently isolated from infected fish with acute gill hemorrhage. CaHV GPCR of 349 amino acids (aa) was identified based on amino acid identity. A series of variants with truncation/deletion/substitution mutation in the C-terminal (aa 315-349) were constructed and expressed in fathead minnow (FHM) cells. The roles of three key C-terminal regions in subcellular localization of CaHV GPCR were determined. Lysine-315 (K-315) directed the aggregation of the protein preferentially at the nuclear side. Predicted N-myristoylation site (GGGWTR, aa 335-340) was responsible for punctate distribution in periplasm or throughout the cytoplasm. Predicted phosphorylation site (SSR, aa 327-329) and GGGWTR together determined the punctate distribution in cytoplasm. Detection of organelles localization by specific markers showed that the protein retaining K-315 colocalized with the Golgi apparatus. These experiments provided first evidence that different mutations of CaHV GPCR C-terminals have different affects on the subcellular localization of fish herpesvirus-encoded GPCRs. The study provided valuable information and new insights into the precise interactions between herpesvirus and fish cells, and could also provide useful targets for antiviral agents in aquaculture.

  16. High resolution modelling of aerosol dispersion regimes during the CAPITOUL field experiment: from regional to local scale interactions

    Directory of Open Access Journals (Sweden)

    B. Aouizerats

    2011-08-01

    Full Text Available High resolution simulation of complex aerosol particle evolution and gaseous chemistry over an atmospheric urban area is of great interest for understanding air quality and processes. In this context, the CAPITOUL (Canopy and Aerosol Particle Interactions in the Toulouse Urban Layer field experiment aims at a better understanding of the interactions between the urban dynamics and the aerosol plumes. During a two-day Intensive Observational Period, a numerical model experiment was set up to reproduce the spatial distribution of specific particle pollutants, from the regional scales and the interactions between different cities, to the local scales with specific turbulent structures. Observations show that local dynamics depends on the day-regime, and may lead to different mesoscale dynamical structures. This study focuses on reproducing these fine scale dynamical structures, and investigate the impact on the aerosol plume dispersion. The 500-m resolution simulation manages to reproduce convective rolls at local scale, which concentrate most of the aerosol particles and can locally affect the pollutant dispersion and air quality.

  17. Distribution of involved regional lymph nodes in recurrent and locally advanced breast cancer and its impact on target definition

    International Nuclear Information System (INIS)

    Chen Jian; Ma Jinli; Zhang Shengjian; Yang Zhaozhi; Cai Gang; Feng Yan; Guo Xiaomao; Chen Jiayi

    2011-01-01

    Objective: The frequency and the anatomic distribution of involved regional nodes in recurrent and locally advanced breast cancer were analyzed, in order to evaluate the rational of conventional regional node radiation technique and provide evidence for target definition of breast cancer . Methods: Patients with recurrent or locally advanced breast cancer who were treated in our hospital from August 2003 to December 2009 were included in this study. 111 patients had contrast enhanced chest CT images of the whole regional nodes before treatment. The regional nodes were categorized into 8 anatomical substructures including medial and lateral supraclavicular nodes ( SC-M, SC-L), axilla nodes ( ALN )- I , II , III, infra clavicular nodes (IFN), Rotter's nodes (RN) and internal mammary nodes (IMN). The frequency of involvement and anatomical distribution of the involved nodes on CT images were analyzed. Results: A total of 111 patients were enrolled this study and 199 anatomical substructures with involved nodes were identified. The frequency of involvement were : SC-M 33, SC-L 21, ALN- I 30, ALN-II 25, ALN-III + IFN 35, RN 27, IMN 28. Supraclavicular region and axilla were the most frequently involved area (72.3%). The average depth of the SC-M and SC-L nodes was 33.48 mm ± 10. 57 mm and 45.62 mm ±20. 45 mm, and 51.5% and 71.4% of the SC-M and SC-L nodes were located more than 3 cm deep from the skin. The axilla nodes were located cranial and caudal to the axillary vein in 5 and 20 locally advanced breast cancer patients and in 64 and 28 patients who received prior axillary dissection. The majority of involved IMN was located within the first 3 intercostal spaces (26/28). The average distance between the center of involved IMN and chest skin was 24. 23 mm ± 10. 28 mm. The average distance between the center of involved IMN and midline of the body was 29. 38 mm ±6. 7 mm. The center of involved IMN was 6.19 mm ±5.73 mm lateral and 5.73 mm ± 4. 56 mm posterior to

  18. Composite selection signals can localize the trait specific genomic regions in multi-breed populations of cattle and sheep

    Science.gov (United States)

    2014-01-01

    Background Discerning the traits evolving under neutral conditions from those traits evolving rapidly because of various selection pressures is a great challenge. We propose a new method, composite selection signals (CSS), which unifies the multiple pieces of selection evidence from the rank distribution of its diverse constituent tests. The extreme CSS scores capture highly differentiated loci and underlying common variants hauling excess haplotype homozygosity in the samples of a target population. Results The data on high-density genotypes were analyzed for evidence of an association with either polledness or double muscling in various cohorts of cattle and sheep. In cattle, extreme CSS scores were found in the candidate regions on autosome BTA-1 and BTA-2, flanking the POLL locus and MSTN gene, for polledness and double muscling, respectively. In sheep, the regions with extreme scores were localized on autosome OAR-2 harbouring the MSTN gene for double muscling and on OAR-10 harbouring the RXFP2 gene for polledness. In comparison to the constituent tests, there was a partial agreement between the signals at the four candidate loci; however, they consistently identified additional genomic regions harbouring no known genes. Persuasively, our list of all the additional significant CSS regions contains genes that have been successfully implicated to secondary phenotypic diversity among several subpopulations in our data. For example, the method identified a strong selection signature for stature in cattle capturing selective sweeps harbouring UQCC-GDF5 and PLAG1-CHCHD7 gene regions on BTA-13 and BTA-14, respectively. Both gene pairs have been previously associated with height in humans, while PLAG1-CHCHD7 has also been reported for stature in cattle. In the additional analysis, CSS identified significant regions harbouring multiple genes for various traits under selection in European cattle including polledness, adaptation, metabolism, growth rate, stature

  19. Climate change in Inner Mongolia from 1955 to 2005-trends at regional, biome and local scales

    Energy Technology Data Exchange (ETDEWEB)

    Lu, N; Wilske, B; John, R; Chen, J [Department of Environmental Sciences, University of Toledo, Toledo, OH 43606 (United States); Ni, J, E-mail: nan.lu@utoledo.ed, E-mail: burkhard.wilske@utoledo.ed, E-mail: jni@ibcas.ac.c, E-mail: ranjeet.john@utoledo.ed, E-mail: jiquan.chen@utoledo.ed [Alfred Wegener Institute for Polar and Marine Research, Telegrafenberg A43, D-14473 Potsdam (Germany)

    2009-10-15

    This study investigated the climate change in Inner Mongolia based on 51 meteorological stations from 1955 to 2005. The climate data was analyzed at the regional, biome (i.e. forest, grassland and desert) and station scales, with the biome scale as our primary focus. The climate records showed trends of warmer and drier conditions in the region. The annual daily mean, maximum and minimum temperature increased whereas the diurnal temperature range (DTR) decreased. The decreasing trend of annual precipitation was not significant. However, the vapor pressure deficit (VPD) increased significantly. On the decadal scale, the warming and drying trends were more significant in the last 30 years than the preceding 20 years. The climate change varied among biomes, with more pronounced changes in the grassland and the desert biomes than in the forest biome. DTR and VPD showed the clearest inter-biome gradient from the lowest rate of change in the forest biome to the highest rate of change in the desert biome. The rates of change also showed large variations among the individual stations. Our findings correspond with the IPCC predictions that the future climate will vary significantly by location and through time, suggesting that adaptation strategies also need to be spatially viable.

  20. Proton beam radiotherapy as part of comprehensive regional nodal irradiation for locally advanced breast cancer.

    Science.gov (United States)

    Verma, Vivek; Iftekaruddin, Zaid; Badar, Nida; Hartsell, William; Han-Chih Chang, John; Gondi, Vinai; Pankuch, Mark; Gao, Ming; Schmidt, Stacey; Kaplan, Darren; McGee, Lisa

    2017-05-01

    This study evaluates acute toxicity outcomes in breast cancer patients treated with adjuvant proton beam therapy (PBT). From 2011 to 2016, 91 patients (93 cancers) were treated with adjuvant PBT targeting the intact breast/chest wall and comprehensive regional nodes including the axilla, supraclavicular fossa, and internal mammary lymph nodes. Toxicity was recorded weekly during treatment, one month following treatment, and then every 6months according to the Common Terminology Criteria for Adverse Events (CTCAE) v4.0. Charts were retrospectively reviewed to verify toxicities, patient parameters, disease and treatment characteristics, and disease-related outcomes. Median follow-up was 15.5months. Median PBT dose was 50.4 Gray relative biological effectiveness (GyRBE), with subsequent boost as clinically indicated (N=61, median 10 GyRBE). Chemotherapy, when administered, was given adjuvantly (N=42) or neoadjuvantly (N=46). Grades 1, 2, and 3 dermatitis occurred in 23%, 72%, and 5%, respectively. Eight percent required treatment breaks owing to dermatitis. Median time to resolution of dermatitis was 32days. Grades 1, 2, and 3 esophagitis developed in 31%, 33%, and 0%, respectively. PBT displays acceptable toxicity in the setting of comprehensive regional nodal irradiation. Copyright © 2017. Published by Elsevier B.V.

  1. Local knowledge of the flora of a region: implications in biodiversity conservation

    Directory of Open Access Journals (Sweden)

    Maria da Conceição Pereira

    2016-11-01

    Full Text Available The flora of a region is important in aesthetic, environmental and economic terms. Academic degree holders are fundamental for the sustainable development of a geographically isolated region such as the Azores, the University of Azores (UAc contributing to that goal. We assessed the perception of the UAc students about the origin and the importance of the Azorean flora for conservation, culture and economy, by applying a questionnaire to 309 students in different scientific areas, addressing origin, symbolic importance, economic importance, and environmental functions. Students showed some knowledge about the concepts of endemic, native, introduced and invasive species, but often failed to connect those to specific plant taxa. Most species cited as symbolic were animals, and the plants mentioned were mainly exotic/invasive. Respondents had a sense of the most important crops and forest species, and attributed several functions related to biodiversity and environmental conservation to the flora. Despite the many actions already implemented, more initiatives are required to increase the connection between Azoreans and Azorean flora.

  2. Climate change in Inner Mongolia from 1955 to 2005-trends at regional, biome and local scales

    International Nuclear Information System (INIS)

    Lu, N; Wilske, B; John, R; Chen, J; Ni, J

    2009-01-01

    This study investigated the climate change in Inner Mongolia based on 51 meteorological stations from 1955 to 2005. The climate data was analyzed at the regional, biome (i.e. forest, grassland and desert) and station scales, with the biome scale as our primary focus. The climate records showed trends of warmer and drier conditions in the region. The annual daily mean, maximum and minimum temperature increased whereas the diurnal temperature range (DTR) decreased. The decreasing trend of annual precipitation was not significant. However, the vapor pressure deficit (VPD) increased significantly. On the decadal scale, the warming and drying trends were more significant in the last 30 years than the preceding 20 years. The climate change varied among biomes, with more pronounced changes in the grassland and the desert biomes than in the forest biome. DTR and VPD showed the clearest inter-biome gradient from the lowest rate of change in the forest biome to the highest rate of change in the desert biome. The rates of change also showed large variations among the individual stations. Our findings correspond with the IPCC predictions that the future climate will vary significantly by location and through time, suggesting that adaptation strategies also need to be spatially viable.

  3. A comparative antibody analysis of Pannexin1 expression in four rat brain regions reveals varying subcellular localizations

    Directory of Open Access Journals (Sweden)

    Angela C Cone

    2013-02-01

    Full Text Available Pannexin1 (Panx1 channels release cytosolic ATP in response to signaling pathways. Panx1 is highly expressed in the central nervous system. We used four antibodies with different Panx1 anti-peptide epitopes to analyze four regions of rat brain. These antibodies labeled the same bands in Western blots and had highly similar patterns of immunofluorescence in tissue culture cells expressing Panx1, but Western blots of brain lysates from Panx1 knockout and control mice showed different banding patterns. Localizations of Panx1 in brain slices were generated using automated wide-field mosaic confocal microscopy for imaging large regions of interest while retaining maximum resolution for examining cell populations and compartments. We compared Panx1 expression over the cerebellum, hippocampus with adjacent cortex, thalamus and olfactory bulb. While Panx1 localizes to the same neuronal cell types, subcellular localizations differ. Two antibodies with epitopes against the intracellular loop and one against the carboxy terminus preferentially labeled cell bodies, while an antibody raised against an N-terminal peptide highlighted neuronal processes more than cell bodies. These labeling patterns may be a reflection of different cellular and subcellular localizations of full-length and/or modified Panx1 channels where each antibody is highlighting unique or differentially accessible Panx1 populations. However, we cannot rule out that one or more of these antibodies have specificity issues. All data associated with experiments from these four antibodies are presented in a manner that allows them to be compared and our claims thoroughly evaluated, rather than eliminating results that were questionable. Each antibody is given a unique identifier through the NIF Antibody Registry that can be used to track usage of individual antibodies across papers and all image and metadata are made available in the public repository, the Cell Centered Database, for on

  4. High Resolution Vp and Vp/Vs Local Earthquake Tomography of the Val d'Agri Region (Southern Apennines, Italy).

    Science.gov (United States)

    Improta, L.; Bagh, S.; De Gori, P.; Pastori, M.; Piccinini, D.; Valoroso, L.; Anselmi, M.; Buttinelli, M.; Chiarabba, C.

    2015-12-01

    The Val d'Agri (VA) Quaternary basin in the southern Apennines extensional belt hosts the largest oilfield in onshore Europe and normal-fault systems with high (up to M7) seismogenic potential. Frequent small-magnitude swarms related to both active crustal extension and anthropogenic activity have occurred in the region. Causal factors for induced seismicity are a water impoundment with severe seasonal oscillations and a high-rate wastewater injection well. We analyzed around 1200 earthquakes (MLENI petroleum company. We used local earthquake tomography to investigate static and transient features of the crustal velocity structure and to accurately locate earthquakes. Vp and Vp/Vs models are parameterized by a 3x3x2 km spacing and well resolved down to about 12 km depth. The complex Vp model illuminates broad antiformal structures corresponding to wide ramp-anticlines involving Mesozoic carbonates of the Apulia hydrocarbon reservoir, and NW-SE trending low Vp regions related to thrust-sheet-top clastic basins. The VA basin corresponds to shallow low-Vp region. Focal mechanisms show normal faulting kinematics with minor strike slip solutions in agreement with the local extensional regime. Earthquake locations and focal solutions depict shallow (< 5 km depth) E-dipping extensional structures beneath the artificial lake located in the southern sector of the basin, and along the western margin of the VA. A few swarms define relatively deep transfer structures accommodating the differential extension between main normal faults. The spatio-temporal distribution of around 220 events correlates with wastewater disposal activity, illuminating a NE-dipping fault between 2-5 km depth in the carbonate reservoir. The fault measures 5 km along dip and corresponds to a pre-existing thrust fault favorably oriented with respect to the local extensional field.

  5. The value of adding regional to local stakeholder involvement in evaluating the acceptability of innovative technologies

    International Nuclear Information System (INIS)

    Peterson, T.S.; McCabe, G.; Niesen, K.; Serie, P.

    1995-02-01

    Technology is urgently needed to clean up contamination by volatile organic compounds at United States Department of Energy (DOE) sites. In many cases, however, existing technology is too slow, inefficient, or expensive. The record of technology development is, in some cases, similarly disappointing. Remediation technologies developed at great expense and evaluated piecemeal over long periods have not been deployed because, in the end, the public judged them ineffective or unacceptable. The need for successful methods of remediation is too great and resources too limited to continue with ineffective technology evaluation. In order to make good decisions about which technologies to deploy, remedial project managers need to know stakeholders' requirements for the performance of proposed technologies. Expanding stakeholder involvement regionally identifies the concerns of a broad range of stakeholders at and DOE sites throughout the West -- issues that must be taken into account if technologies are to be accepted for wide deployment

  6. Evidence of local and regional freshening of Northeast Greenland coastal waters

    DEFF Research Database (Denmark)

    Sejr, Mikael K.; Stedmon, Colin A; Bendtsen, Jørgen

    2017-01-01

    The supply of freshwater to fjord systems in Greenland is increasing as a result of climate change-induced acceleration in ice sheet melt. However, insight into the marine implications of the melt water is impaired by lack of observations demonstrating the fate of freshwater along the Greenland...... coast and providing evaluation basis for ocean models. Here we present 13 years of summer measurements along a 120 km transect in Young Sound, Northeast Greenland and show that sub-surface coastal waters are decreasing in salinity with an average rate of 0.12 ± 0.05 per year. This is the first...... observational evidence of a significant freshening on decadal scale of the waters surrounding the ice sheet and comes from a region where ice sheet melt has been less significant. It implies that ice sheet dynamics in Northeast Greenland could be of key importance as freshwater is retained in southward flowing...

  7. Spatial and topographic trends in forest expansion and biomass change, from regional to local scales.

    Science.gov (United States)

    Buma, Brian; Barrett, Tara M

    2015-09-01

    Natural forest growth and expansion are important carbon sequestration processes globally. Climate change is likely to increase forest growth in some regions via CO2 fertilization, increased temperatures, and altered precipitation; however, altered disturbance regimes and climate stress (e.g. drought) will act to reduce carbon stocks in forests as well. Observations of asynchrony in forest change is useful in determining current trends in forest carbon stocks, both in terms of forest density (e.g. Mg ha(-1) ) and spatially (extent and location). Monitoring change in natural (unmanaged) areas is particularly useful, as while afforestation and recovery from historic land use are currently large carbon sinks, the long-term viability of those sinks depends on climate change and disturbance dynamics at their particular location. We utilize a large, unmanaged biome (>135 000 km(2) ) which spans a broad latitudinal gradient to explore how variation in location affects forest density and spatial patterning: the forests of the North American temperate rainforests in Alaska, which store >2.8 Pg C in biomass and soil, equivalent to >8% of the C in contiguous US forests. We demonstrate that the regional biome is shifting; gains exceed losses and are located in different spatio-topographic contexts. Forest gains are concentrated on northerly aspects, lower elevations, and higher latitudes, especially in sheltered areas, whereas loss is skewed toward southerly aspects and lower latitudes. Repeat plot-scale biomass data (n = 759) indicate that within-forest biomass gains outpace losses (live trees >12.7 cm diameter, 986 Gg yr(-1) ) on gentler slopes and in higher latitudes. This work demonstrates that while temperate rainforest dynamics occur at fine spatial scales (biomass accumulation suggest the potential for relatively rapid biome shifts and biomass changes. © 2015 John Wiley & Sons Ltd.

  8. Diagnosis and fine localization of deletion region in Wolf-Hirschhorn syndrome patients.

    Science.gov (United States)

    Ji, Tao-Yun; Chia, David; Wang, Jing-Min; Wu, Ye; Li, Jie; Xiao, Jing; Jiang, Yu-Wu

    2010-07-01

    Wolf-Hirschhorn syndrome (WHS) results from the partial deletion of 4p. This study aimed to identify and fine map the chromosome deletion regions of Chinese children with Wolf-Hirschhorn syndrome among the developmental delay/mental retardation (DD/MR) patients. We analyzed the relationship of phenotype and genotype. Inclusion criteria were: moderate to severe DD/MR, no definite perinatal brain injury, and no trauma, toxication, hypoxia, infection of central nervous system; routine karyotyping was normal, no evidence of typical inherited metabolic disorder or specific neurodegenerative disorders from cranial neuro-imaging and blood/urinary metabolic diseases screening; no mutation of FMR1 in male patients, no typical clinical manifestation of Rett syndrome in female patients. Multiplex ligation-dependent probe amplification (MLPA) and Affymetrix genome-wide human SNP array 6.0 assays were applied to accurately define the exact size of subtelomeric aberration region of four WHS patients. All four WHS patients presented with severe DD, hypotonia and microcephaly, failure to thrive, 3/4 patients with typical facial features and seizures, 2/4 patients with congenital heart defects and cleft lip/palate, 1/4 patients with other malformations. The length of the deletions ranged from 3.3 Mb to 9.8 Mb. Two of four patients had "classic" WHS, 1/4 patients had "mild"-to-"classic" WHS, and 1/4 patients had "mild" WHS. WHS patients in China appear to be consistent with those previously reported. The prevalence of signs and symptoms, distribution of cases between "mild" and "classic" WHS, and the correlation between length of deletion and severity of disease of these patients were all similar to those of the patients from other populations.

  9. Spatial patterns of diversity at local and regional scales in a tropical lagoon

    Directory of Open Access Journals (Sweden)

    José Adán Caballero-Vázquez

    Full Text Available The present study reports estimates of alpha (α, beta (β and gamma (Γ diversity for the fish community of Chacmochuch Lagoon (SE Mexico, a natural protected area located in the northern portion of the Mesoamerican Barrier Reef System. Fish specimens were sampled in 2004 and 2006. Field work was carried out at three climatic peaks: at 13 stations using a 70 m-long beach seine. The collected data were supplemented with information obtained from a previous work conducted in 2002 and were then analyzed with multivariate statistical methods. In addition, fish composition results from this study were compared to those reported for other similar ecosystems of the region. A total of 68 fish species were recorded, determined as peripheral (high-salinity species, usually marine affinity most of them. Most of the fish species collected were determined as rare, and a few number of species were determined as common and dominant. Salinity, TSD, temperature, dissolved oxygen and other variables were measured to determine the influence over the fish communities, four groups of sites where determined. Results indicated a gradual decrease in the degree of species replacement towards the interior of the system (away from the coast. The estimated value of gamma diversity was high compared to that reported for other coastal systems of the region and, due to the high degree of habitat heterogeneity found in this system; beta diversity had a greater contribution to gamma diversity than alpha diversity. This lagoon acts as a nursing area for many of the fish species collected in this study as indicated by the presence of juvenile stages.

  10. Analysis of Tourism Resource Dependency on Collaboration among Local Governments in the Multi-Regional Tourism Development

    Directory of Open Access Journals (Sweden)

    Ha Dong-Won

    2014-01-01

    Full Text Available The purpose of this study was to derive the multidimensional attributes of resource dependency of local governments in multi-regional tourism development. The questionnaire was designed based on resource dependence theory and related literature, and five factors of resource dependency were derived by analysis of the questionnaire for the civil servants who participated in the Jirisan area tourism development project which is a representative multi-regional tourism development project of Korea. The measured values of the derived possession, importance, discretion, alternative, and connection were found in various ways according to the project characteristics such as project scale and visitors in the Jirisan area tourism development project. This shows that a variety of variables have an effect on resource dependency.

  11. Geovisualization of Local and Regional Migration Using Web-mined Demographics

    Science.gov (United States)

    Schuermann, R. T.; Chow, T. E.

    2014-11-01

    The intent of this research was to augment and facilitate analyses, which gauges the feasibility of web-mined demographics to study spatio-temporal dynamics of migration. As a case study, we explored the spatio-temporal dynamics of Vietnamese Americans (VA) in Texas through geovisualization of mined demographic microdata from the World Wide Web. Based on string matching across all demographic attributes, including full name, address, date of birth, age and phone number, multiple records of the same entity (i.e. person) over time were resolved and reconciled into a database. Migration trajectories were geovisualized through animated sprites by connecting the different addresses associated with the same person and segmenting the trajectory into small fragments. Intra-metropolitan migration patterns appeared at the local scale within many metropolitan areas. At the scale of metropolitan area, varying degrees of immigration and emigration manifest different types of migration clusters. This paper presents a methodology incorporating GIS methods and cartographic design to produce geovisualization animation, enabling the cognitive identification of migration patterns at multiple scales. Identification of spatio-temporal patterns often stimulates further research to better understand the phenomenon and enhance subsequent modeling.

  12. Population, Environment, and Climate in the Albertine Rift: Understanding Local Impacts of Regional Change

    Science.gov (United States)

    Hartter, J.; Ryan, S. J.; Diem, J.; Palace, M. W.

    2012-12-01

    Climate change is of critical concern for conservation and to develop appropriate policies and responses, it is important not only to anticipate the nature of changes, but also how they are perceived, interpreted and adapted to by local people. The Albertine Rift in East Africa is one of the most threatened biodiversity hotspots due to dense settlement, extreme poverty, and land conversion. We synthesize ongoing NSF-CNH research, where Ugandan park landscapes are examined to understand the impacts of climate change on livelihoods. Kibale National Park, the main study site, exemplifies the challenges facing many parks because of its isolation within a densely populated agricultural landscape. Three separate household surveys (n=251, 130, 100) reveal that the most perceived benefits provided by Kibale were ecosystem services and farmers cite rainfall as one of the park's most important benefits, but are also concerned with variable precipitation. Analysis of 30+ years of daily rainfall station data shows total rainfall has not changed significantly, but timing and transitions of seasons and intra-seasonal distribution are highly variable, which may contribute to changes in farming schedules and threaten food security. Further, the contrast between land use/cover change over 25 years around the park and the stability of forest within the park underscores the need to understand this landscape for future sustainability planning and the inevitable population growth outside its boundaries. Understanding climate change impacts and feedbacks to and from socio-ecological systems are important to address the dual challenge of biodiversity conservation and poverty alleviation.

  13. Drinking pattern and its relation to hemoglobin concentration in local brew consumers from the Kathmandu Region

    Institute of Scientific and Technical Information of China (English)

    Arun Kumar

    2009-01-01

    The study was conducted to determine the hemoglobin concentration in alcohol consumers (home made brew-Chang) and compare it with non- alcohohcs healthy subjects. Hemoglobin (Hb) concentration was determined in 2053 alcoholic consumers (males: 1056; females: 997) and was compared with 1 027 (males: 623; females: 404) healthy non-alcoholic con-trol subjects. The Hb concentration in alcoholic male and female were 13.42 ± 2.14 g/dL and 12.19 ± 1.55 g/dL compared with control showing 14.43 ± 1.07 g/dL and 12.73 ± 1.41 g/dL in males and females respectively. The differences in Hb concentration between alcoholic and non- alcoholic consumers were highly significant in both genders with a P value of 0. 000 674 in males and 0.004 732 in females. Alcohol Use Disorders Identification test (AUDIT) scores was advocated to alcoholic consum-ers to test the severity of drunkenness and disorders related to it. A total of 887 males and 663 females crossed the cut-off limits of ≥8 AUDIT scores showing the addiction towards drinking habits of local brew.

  14. NEO-INSTITUTIONALISM AND ENDOGENOUS DEVELOPMENT AS REGIONAL ALTERNATIVE. MODERNITY AND SUBJECTIVITY, LINKING AND LOCAL DEVELOPMENT

    Directory of Open Access Journals (Sweden)

    José Mateo Bastidas-Morales

    2015-01-01

    Full Text Available The reconstruction of subjectivity involves overcoming criticism of individualism, utilitarianism and immediacy as the basis of society and consumer markets. Elemental is, with the addition of the individual as a subject of social action, the principal actor-oriented definition of welfare, community and local development. Obviously, the formation of human capital development. While it is imperative the state-society relationship in the context of the current modernization must also recover the principles of the community before the stressed relationship between the market-state. We intend here to link opposite the dichotomous thinking of Western rationalism, constitute an important element of social sustantivación. Along with this, the neo-institutionalism and institutional economics that questions the current neoliberal approves the participation of the state and, with new rules, can better confront the neoconservative positions. It is revalued, in the present work, interest in the new dynamics of social change in post-national or cosmopolitan side.

  15. LOCAL REGULATIONS ON ALTERNATIVE WATER SOURCES: GREYWATER AND RAINWATER USE IN THE METROPOLITAN REGION OF BARCELONA

    Directory of Open Access Journals (Sweden)

    Laia Domènech

    2014-01-01

    Full Text Available Las fuentes alternativas de agua están ganando importancia en Cataluña (nordeste de España como resultado de las nuevas políticas locales que promueven la conservación del agua y una mayor resiliencia frente a episodios de sequía. Desde 2002, más de 50 municipios (incluyendo en total más de 1.3 millones de personas han aprobado ordenanzas municipales de ahorro de agua, las cuáles exigen la instalación de sistemas de captación de aguas pluviales y reutilización de aguas grises en edificios de nueva construcción. Estas nuevas tecnologías transforman el ciclo hídrico existente e inducen importantes cambios institucionales y sociales relacionados con la descentralización de la gestión del agua. A partir de una serie de entrevistas con técnicos municipales y encuestas con usuarios de sistemas de aguas grises y pluviales, este artículo analiza el aprendizaje socio-técnico generado durante la implementación de las ordenanzas y los principales impedimentos y barreras que deben ser superados para minimizar los riesgos para la salud y promover la aceptación social de estas fuentes de agua alternativas.

  16. Modes of Governing and Policy of Local and Regional Governments Supporting Local Low-Carbon Energy Initiatives; Exploring the Cases of the Dutch Regions of Overijssel and Fryslân

    Directory of Open Access Journals (Sweden)

    Beau Warbroek

    2017-01-01

    Full Text Available Recent scholarly attention shows increasing involvement of local low-carbon energy initiatives (LLCEIs in governance and policy, in particular in relation to innovations regarding low-carbon energy and energy efficiency. The future perspective of active citizenship in the production of locally generated low-carbon energy is largely dependent on the existing institutional and policy frameworks and settings. Subnational governments, in particular, can have a prominent role in this process by engaging in institutional adaptation and policy innovation. The central research question of this paper is: In what ways do local and regional governments innovate in governing to respond to the emergence of LLCEIs? The research question is answered by comparing two case studies: the Dutch regions of Overijssel and Fryslân. We have conceptualized a meta-governing approach of experimentation, characterizing the innovations in governing that emerge when governments respond to the emergence of LLCEIs. We specifically focus on two capacities that subnational governments can use to enhance their governing capacity vis-à-vis LLCEIs and which substantiate the experimental meta-governance mode: institutional adaptation and policy innovation. We then formulated hypotheses that specify the expected policy innovations and institutional adaptations employed vis-à-vis LLCEIs. Data collection involved in-depth interviews and use of secondary data. The results show that a balancing process of authoritative and enabling modes of governing particularly characterized the type of policy innovations that were developed and the institutional adaptations that took place. Both provinces govern LLCEIs at arm’s length and issue significant capacity-building strategies that vary in terms of their conditions. Municipalities, however, incline towards impromptu and opportunistic responses, some of them having lasting effects by patching up existing institutional settings, others

  17. Local time dependence of the thermal structure in the Venusian equatorial region revealed by Akatsuki radio occultation measurements

    Science.gov (United States)

    Ando, H.; Fukuhara, T.; Takagi, M.; Imamura, T.; Sugimoto, N.; Sagawa, H.

    2017-12-01

    The radio occultation technique is one of the most useful methods to retrieve vertical temperature profiles in planetary atmospheres. Ultra-Stable Oscillator (USO) onboard Venus Climate Orbiter, Akatsuki, enables us to investigate the thermal structure of the Venus atmosphere between about 40-90 km levels. It is expected that 35 temperature profiles will be obtained by the radio occultation measurements of Akatsuki until August 2017. Static stability derived from the temperature profiles shows its local time dependence above the cloud top level at low-latitudes equatorward of 25˚. The vertical profiles of the static stability in the dawn and dusk regions have maxima at 77 km and 82 km levels, respectively. A general circulation model (GCM) for the Venus atmosphere (AFES-Venus) reproduced the thermal structures above the cloud top qualitatively consistent with the radio occultation measurements; the maxima of the static stability are seen both in the dawn and dusk regions, and the local maximum of the static stability in the dusk region is located at a highler level than in the dawn region. Comparing the thermal structures between the radio occultation measurements and the GCM results, it is suggested that the distribution of the static stability above the cloud top could be strongly affected by the diurnal tide. The thermal tide influences on the thermal structure as well as atmospheric motions above the cloud level. In addition, it is shown that zonally averaged zonal wind at about 80 km altitude could be roughly estimated from the radio occultation measurements using the dispersion relation of the internal gravity wave.

  18. Long-term regional shifts in plant community composition are largely explained by local deer impact experiments.

    Directory of Open Access Journals (Sweden)

    Katie Frerker

    Full Text Available The fact that herbivores and predators exert top-down effects to alter community composition and dynamics at lower trophic levels is no longer controversial, yet we still lack evidence of the full nature, extent, and longer-term effects of these impacts. Here, we use results from a set of replicated experiments on the local impacts of white-tailed deer to evaluate the extent to which such impacts could account for half-century shifts in forest plant communities across the upper Midwest, USA. We measured species' responses to deer at four sites using 10-20 year-old deer exclosures. Among common species, eight were more abundant outside the exclosures, seven were commoner inside, and 16 had similar abundances in- and outside. Deer herbivory greatly increased the abundance of ferns and graminoids and doubled the abundance of exotic plants. In contrast, deer greatly reduced tree regeneration, shrub cover (100-200 fold in two species, plant height, plant reproduction, and the abundance of forbs. None of 36 focal species increased in reproduction or grew taller in the presence of deer, contrary to expectations. We compared these results to data on 50-year regional shifts in species abundances across 62 sites. The effects of herbivory by white-tailed deer accurately account for many of the long-term regional shifts observed in species' abundances (R2 = 0.41. These results support the conjecture that deer impacts have driven many of the regional shifts in forest understory cover and composition observed in recent decades. Our ability to link results from shorter-term, local experiments to regional long-term studies of ecological change strengthens the inferences we can draw from both approaches.

  19. Evidence for intact local connectivity but disrupted regional function in the occipital lobe in children and adolescents with schizophrenia.

    Science.gov (United States)

    White, Tonya; Moeller, Steen; Schmidt, Marcus; Pardo, Jose V; Olman, Cheryl

    2012-08-01

    It has long been known that specific visual frequencies result in greater blood flow to the striate cortex. These peaks are thought to reflect synchrony of local neuronal firing that is reflective of local cortical networks. Since disrupted neural connectivity is a possible etiology for schizophrenia, our goal was to investigate whether localized connectivity, as measured by aberrant synchrony, is abnormal in children and adolescents with schizophrenia. Subjects included 25 children and adolescents with schizophrenia and 39 controls matched for age and gender. Subjects were scanned on a Siemens 3 Tesla Trio scanner while observing flashing checkerboard presented at either 1, 4, 8, or 12 Hz. Image processing included both a standard GLM model and a Fourier transform analysis. Patients had significantly smaller volume of activation in the occipital lobe compared to controls. There were no differences in the integral or percent signal change of the hemodynamic response function for each of the four frequencies. Occipital activation was stable during development between childhood and late adolescence. Finally, both patients and controls demonstrated an increased response between 4 and 8 Hz consistent with synchrony or entrainment in the neuronal response. Children and adolescents with schizophrenia had a significantly lower volume of activation in the occipital lobe in response to the flashing checkerboard task. However, features of intact local connectivity in patients, such as the hemodynamic response function and maximal response at 8 Hz, were normal. These results are consistent with abnormalities in regional connectivity with preserved local connectivity in early-onset schizophrenia. Copyright © 2011 Wiley Periodicals, Inc.

  20. Evaluation of the functional activity of activated sludge from local waste water treatment plant in the Arctic region

    Directory of Open Access Journals (Sweden)

    Il'inskiy V. V.

    2017-03-01

    Full Text Available The paper considers characteristics of the activated sludge in the local wastewater treatment plant (LWTP and its ability to purify fully domestic sewage water in the Far North. Biochemical process of destruction of organic pollutants is influenced by a microbial complex functioning in aeration tanks. Taking into account climatic conditions of the region where the organic matter degradation processes are slowed, and lack of control over the operation, efficiency and occupational safety of LWTPs, it seems to be important to study the physiological characteristics of the bacteria used in bioremediation, and their ability to maximize the purifying domestic sewage in the Arctic region. Undue intervention in the biosphere systems leads to disruption of the balance of internal and external ecosystems communications. The goal of research is studying structural determination and functioning of activated sludge bacteriocenosis of LWTP TOPAS-5 (GK "Topol-ECO" in certain physical and chemical conditions of the habitat, and establishing completeness of cleaning process in this treatment plant. The paper considers the structure (quantitative and qualitative composition and function of LWTP activated sludge bacteriocenosis functioning in the Arctic region. The estimation of the activated sludge of full waste water treatment process of the LWTP has been given. The research's results have allowed to identify and determine the bacterial count of physiological groups of microorganisms purified domestic sewage; to isolate from activated sludge the bioflocculant-producing microorganisms' on the experimental medium; to evaluate efficiency of LWTP work in the Arctic region

  1. A Systematic Exploration of the Local and Remote Climate Effects of Anthropogenic Aerosol Emissions from Key Regions

    Science.gov (United States)

    Voulgarakis, A.; Kasoar, M.; Shawki, D.; Lamarque, J. F.; Shindell, D. T.; Faluvegi, G.; Bellouin, N.; Collins, W.; Tsigaridis, K.

    2016-12-01

    The radiative forcing of short-lived pollutants such as aerosols and tropospheric ozone is highly inhomogeneous and can therefore affect regional temperature, circulation and precipitation in a much more complicated way than the forcing of well-mixed greenhouse gases. Such effects have only recently started to be examined thoroughly and systematically from a global point of view, to understand regional interactions. Here, after outlining some key past work in this area, results from recent simulations with the UK Met Office's HadGEM3 global composition-climate model will be presented in which anthropogenic emissions of sulfur dioxide (SO2) and black carbon in key regions (East Asia, South Asia, Europe, the US, and the northern mid-latitudes as a whole) have been removed. The linkages between emissions, concentrations, radiative forcing, temperature and precipitation responses will be discussed. A particular emphasis will be placed on non-local effects, i.e. how emissions over a certain region can affect other areas remotely. Finally, we will contrast our results with those from similar experiments pursued using the NASA GISS-E2 and the NCAR CESM1 models for US and East Asian SO2 emissions, and will discuss the large differences in the models' behaviour.

  2. The Magnetic Local Time Distribution of Energetic Electrons in the Radiation Belt Region

    Science.gov (United States)

    Allison, H. J.

    2017-12-01

    Using fourteen years of electron flux data from the National Oceanic and Atmospheric Administration Polar Operational Environmental Satellites (POES), a statistical study of the magnetic local time (MLT) distribution of the electron population is performed across a range of activity levels, defined by AE, AE*, Kp, solar wind velocity (Vsw), and VswBz. Three electron energies (>30, >100, and >300 keV) are considered. Dawn-dusk flux asymmetries larger than order of magnitude were observed for >30 and >100 keV electrons. For >300 keV electrons, dawn-dusk asymmetries were primarily due to a decrease in the average dusk-side flux beyond L* ˜ 4.5 that arose with increasing activity. For the >30 keV population, substorm injections enhance the dawn-side flux, which may not reach the dusk-side as the electrons can be on open drift paths and lost to the magnetopause. The asymmetries in the >300 keV population are attributed to the combination of magnetopause shadowing and >300 keV electron injections by large electric fields. We suggest that 3D radiation belt models could set the minimum energy boundary (Emin) to 30 keV or above at L* ˜6 during periods of low activity. However, for more moderate conditions, Emin should be larger than 100 keV and, for very extreme activities, ˜300 keV. Our observations show the extent that in-situ electron flux readings may vary during active periods due to the MLT of the satellite and highlight the importance of 4D radiation belt models to fully understand radiation belt processes.

  3. Investigations into the Regional and Local Timescale Variations of Subglacial Drainage Networks

    Science.gov (United States)

    Hiester, Justin

    Subglacial water plays an important role in the regulation of an ice sheet's mass balance. It may be the dominant control on the velocities of ice streams and outlet glaciers on scales of months to millennia. Recent satellite observations of ice surface elevation changes have given researchers new insights into how subglacial water is stored and transported. Localized uplift and settling of the ice surface implies that lakes exist beneath the ice sheet that are being filled and drained on relatively short time scales. At the base of an ice sheet water can be transported through a variety of drainage networks or stored in subglacial lakes. Here, a numerical investigation of the mechanisms of transport and storage of subglacial water and the associated time scales is presented. Experiments are carried out using a finite element model of coupled ice and water flow. The first experiment seeks to understand the relationship between the depth of a basal depression and the area over which the feature affects basal water flow. It is found that as the perturbation to a topographic depression's depth is increased, water is rerouted in response to the perturbation. Additionally it is found that the relationship between perturbation depth and the extent upstream to which its effects reach is nonlinear. The second experiment examines how the aspect ratio of bed features (prolate, oblate, or equidimensional) influences basal water flow. It is found that the systems that develop and their interactions are mediated by both the topography and the feedbacks taken into account by the coupling of the systems in the model. Features oriented parallel to ice and water flow are associated with distributed fan systems that develop branches which migrate laterally across the domain and interact with one another on monthly and yearly timescales. Laterally oriented features develop laterally extensive ponds. As the ratio of longitudinal to lateral dimension of the topography is increased, a

  4. Non-local energy deposition: A problem in regional RF hyperthermia

    International Nuclear Information System (INIS)

    Hagmann, M.J.; Levin, R.L.

    1984-01-01

    As the frequency is decreased below 1 GHz, RF applicators can cause deep heating of tissues. However, there is a concomitant problem in that significant energy deposition may occur well beyond the dimensions of the applicator. The BSD Medical Corporation has described to the authors tests with a phantom manequin in which SAR in the neck was significantly greater than that in the abdomen when an Annular Phased Array System (APAS) was positioned for abdominal heating. The authors have obtained numerical solutions for the SAR distribution in a 180-cell inhomogeneous block model of man subjected to r-f irradiation approximating that emanating from various applicators. The solutions agree with the reports of BSD that significant heating in the neck, inner thighs, and back will occur with an abdominally-placed APAS. They suggest that a similar problem will occur with a helical-coil or other applicator for which the electric field is predominantly parallel to the axis of the body. Typically, 70% or more of the total energy will be deposited outside the bounds of an axial applicator when it is placed around the chest or abdomen. The problem is most severe at frequencies for which body parts such as the arm or head may resonate. In such cases, over 90% of the energy may be deposited outside the bounds of applicator. The problem of non-local energy deposition appears to be substantially reduced for non-axial applicators. If the arm extends outward from the side of the body, an axial applicator around it will cause negligible energy deposition in the rest of the body

  5. An educational international partnership responding to local needs: process evaluation of the Brazil FAIMER Regional Institute.

    Science.gov (United States)

    Amaral, E; Campos, H H; Friedman, S; Morahan, P S; Araujo, M N T; Carvalho, P M; Bollela, V; Ribeiro, M G F; Mennin, S; Haddad, A E; Campos, F

    2012-11-01

    The Brazilian public health system requires competent professionals sensitive to the needs of the population. The Foundation for Advancement of International Medical Education and Research (FAIMER) provides a two-year faculty development programme for health professions educators, aiming to build leadership in education to improve health. A partnership with governmental initiatives and FAIMER was established for meeting these needs. This paper describes the initial process evaluation results of the Brazilian FAIMER Institute Fellowship (FAIMER BR). Data were analysed for the classes 2007-2010 regarding: application processes; innovation project themes; retrospective post-pre self-ratings of knowledge acquisition; and professional development portfolios. Seventeen of 26 Brazilian states were represented among 98 Fellows, predominantly from public medical schools (75.5%) and schools awarded Ministry of Health grants to align education with public health services (89.8%). One-third (n = 32) of Fellows' innovation projects were related to these grants. Significant increases occurred in all topic subscales on self-report of knowledge acquisition (effect sizes, 1.21-2.77). In the follow up questionnaire, 63% of Fellows reported that their projects were incorporated into the curriculum or institutional policies. The majority reported that the programme deepened their knowledge (98%), provided new ideas about medical education (90%) and provided skills for conflict management (63%). One-half of the Fellows reported sustained benefits from the programme listserv and other communications, including breadth of expertise, establishment of research collaboration and receiving emotional support. Contributors to initial programme success included alignment of curriculum with governmental initiatives, curriculum design merging educational technology, leadership and management skills and central role of an innovation educational project responding to local needs.

  6. Local cytokine changes in complex regional pain syndrome type I (CRPS I) resolve after 6 months.

    Science.gov (United States)

    Lenz, Melanie; Uçeyler, Nurcan; Frettlöh, Jule; Höffken, Oliver; Krumova, Elena K; Lissek, Silke; Reinersmann, Annika; Sommer, Claudia; Stude, Philipp; Waaga-Gasser, Ana M; Tegenthoff, Martin; Maier, Christoph

    2013-10-01

    There is evidence that inflammatory processes are involved in at least the early phase of complex regional pain syndrome (CRPS). We compared a panel of pro- and antiinflammatory cytokines in skin blister fluids and serum from patients with CRPS and patients with upper-limb pain of other origin (non-CRPS) in the early stage (CRPS patients compared to non-CRPS patients. Neither group showed side differences. After 6 months under analgesic treatment, protein levels of all measured cytokines in CRPS patients, except for IL-6, significantly changed bilaterally to the level of non-CRPS patients. These changes were not related to treatment outcome. In serum, only IL-8, TNF-α, eotaxin, MCP-1, and MIP-1β were detectable without intergroup differences. Blister fluid of CRPS patients showed a bilateral proinflammatory cytokine profile. This profile seems to be relevant only at the early stage of CRPS. Almost all measured cytokine levels were comparable to those of non-CRPS patients after 6 months of analgesic treatment and were not related to treatment outcome. Copyright © 2013 International Association for the Study of Pain. Published by Elsevier B.V. All rights reserved.

  7. MODALITIES OF LOCAL DEBT ANALYSIS IN THE NORTH-WEST REGION OF ROMANIA

    Directory of Open Access Journals (Sweden)

    Ioan BĂTRÂNCEA

    2016-12-01

    Full Text Available Public debt is a topic of great interest, problem tracked over the years and has worsened with the outbreak of the second wave of financial crisis around the world, namely the sovereign debt crisis . Among the countries affected by this phenomenon are, along with countries like Greece, Italy, Spain and Portugal, our country whose public debt has doubled in the past four years and will affect future regional development in Romania. In late 2010, the Romanian government debt (according to ESA 95 methodology reached 31.02 % of GDP. Although this indicator falls comfortably within the 60 % of GDP Maastricht Treaty, its growth rate remains worrying. In 2012 there was a level of government debt ( EU methodology - ESC 95 37.8 % of GDP, and for 2013 the estimated level of government debt is below 36.4 % of GDP ( 51 billion euro ranging is below the Maastricht Treaty provided for 60% of GDP, an advantage for Romania , given the new rules on public debt and budget deficit introduced by the new rules of economic governance at the European level , the concept of prudent fiscal policy becomes central . This is a reason for adopting a pro- active stance by continuing fiscal consolidation measures. That is why in this paper the authors present an analysis of public debt based on a correlated system of indicators.

  8. Grassland/atmosphere response to changing climate: Coupling regional and local scales

    International Nuclear Information System (INIS)

    Coughenour, M.B.; Kittel, T.G.F.; Pielke, R.A.; Eastman, J.

    1993-10-01

    The objectives of the study were: to evaluate the response of grassland ecosystems to atmospheric change at regional and site scales, and to develop multiscaled modeling systems to relate ecological and atmospheric models with different spatial and temporal resolutions. A menu-driven shell was developed to facilitate use of models at different temporal scales and to facilitate exchange information between models at different temporal scales. A detailed ecosystem model predicted that C 3 temperate grasslands wig respond more strongly to elevated CO 2 than temperate C 4 grasslands in the short-term while a large positive N-PP response was predicted for a C 4 Kenyan grassland. Long-term climate change scenarios produced either decreases or increases in Colorado plant productivity (NPP) depending on rainfall, but uniform increases in N-PP were predicted in Kenya. Elevated CO 2 is likely to have little effect on ecosystem carbon storage in Colorado while it will increase carbon storage in Kenya. A synoptic climate classification processor (SCP) was developed to evaluate results of GCM climate sensitivity experiments. Roughly 80% agreement was achieved with manual classifications. Comparison of lx and 2xCO 2 GCM Simulations revealed relatively small differences

  9. The Surface Energy Balance at Local and Regional Scales-A Comparison of General Circulation Model Results with Observations.

    Science.gov (United States)

    Garratt, J. R.; Krummel, P. B.; Kowalczyk, E. A.

    1993-06-01

    Aspects of the mean monthly energy balance at continental surfaces are examined by appeal to the results of general circulation model (GCM) simulations, climatological maps of surface fluxes, and direct observations. Emphasis is placed on net radiation and evaporation for (i) five continental regions (each approximately 20°×150°) within Africa, Australia, Eurasia, South America, and the United States; (ii) a number of continental sites in both hemispheres. Both the mean monthly values of the local and regional fluxes and the mean monthly diurnal cycles of the local fluxes are described. Mostly, GCMs tend to overestimate the mean monthly levels of net radiation by about 15% -20% on an annual basis, for observed annual values in the range 50 to 100 Wm2. This is probably the result of several deficiencies, including (i) continental surface albedos being undervalued in a number of the models, resulting in overestimates of the net shortwave flux at the surface (though this deficiency is steadily being addressed by modelers); (ii) incoming shortwave fluxes being overestimated due to uncertainties in cloud schemes and clear-sky absorption; (iii) land-surface temperatures being under-estimated resulting in an underestimate of the outgoing longwave flux. In contrast, and even allowing for the poor observational base for evaporation, there is no obvious overall bias in mean monthly levels of evaporation determined in GCMS, with one or two exceptions. Rather, and far more so than with net radiation, there is a wide range in values of evaporation for all regions investigated. For continental regions and at times of the year of low to moderate rainfall, there is a tendency for the simulated evaporation to be closely related to the precipitation-this is not surprising. In contrast, for regions where there is sufficient or excessive rainfall, the evaporation tends to follow the behavior of the net radiation. Again, this is not surprising given the close relation between

  10. Convergence and divergence between the local and regional state around solid waste management. An unresolved problem in the Sacred Valley

    Directory of Open Access Journals (Sweden)

    Teresa Tupayachi Mar

    2012-12-01

    Full Text Available This article and the following «The Material Politics of Waste Disposal - decentralization and integrated systems» from Penelope Harvey are published as complementary accounts on the management of solid waste in the Vilcanota Valley in Cusco. Penelope Harvey and Teresa Tupayachi worked together on this theme. In this paper, Tupayachi introduces the legal framing for the politics of waste disposal in the region. She also presents two studies that were commissioned in order to find solutions to the problem of waste disposal. The first was carried out in 2003, with finance from Finnish development cooperation funds, in co-ordination with technical experts from various universities, NGOs and state agencies, including the municipality of Urubamba. The second, a component of the Vilcanota project, was completed in 2011. The studies have things in common. Both involve regional and local government as central agents in the process, both focus their efforts to resolve the problem of solid waste management on possible technical solutions, and both are well resourced in both financial and human terms. However neither succeed in finding a way to accommodate the diverse interests and perceptions of the municipalities and of the general public. Faced with this situation local government officials, and people in general act on their own initiative, finding decentralized, and at times informal solutions to the problem, taking advantage of market opportunities.

  11. Monitoring Local Regional Hemodynamic Signal Changes during Motor Execution and Motor Imagery Using Near-Infrared Spectroscopy

    Directory of Open Access Journals (Sweden)

    Naoki eIso

    2016-01-01

    Full Text Available The aim of this study was to clarify the topographical localization of motor-related regional hemodynamic signal changes during motor execution (ME and motor imagery (MI by using near-infrared spectroscopy (NIRS, as this technique is more clinically expedient than established methods (e.g. fMRI. Twenty right-handed healthy subjects participated in this study. The experimental protocol was a blocked design consisting of 3 cycles of 20 s of task performance and 30 s of rest. The tapping sequence task was performed with their fingers under 4 conditions: ME and MI with the right or left hand. Hemodynamic brain activity was measured with NIRS to monitor changes in oxygenated hemoglobin (oxy-Hb concentration. Oxy-Hb in the somatosensory motor cortex (SMC increased significantly only during contralateral ME and showed a significant interaction between task and hand. There was a main effect of hand in the left SMC. Although there were no significant main effects or interactions in the supplemental motor area (SMA and premotor area (PMA, oxy-Hb increased substantially under all conditions. These results clarified the topographical localization by motor-related regional hemodynamic signal changes during ME and MI by using NIRS.

  12. The Regional and Local Distribution of Funds Allocated by the European Agricultural Fund for Rural Development in Romania

    Directory of Open Access Journals (Sweden)

    ALINA-MIRELA MARCU

    2013-01-01

    Full Text Available The objective of this study is to present and analyze the regional and local distribution of the funds allocated by the European Agricultural Fund for Rural Development (EAFRD, European fund that finances rural development in Romania, in the post-accession period. This financing instrument was created by the European Union with the order to continue the main directions of investment of Special Pre-Accession Programme for Agriculture and Rural Development (SAPARD. As a member state of the European Union, Romania observes the principles of the Common Agricultural Policy (CAP while the development of the Romanian rural area for the programming period 2007-2013 is supported by the European Community through the National Rural Development Programme (RDP. This approach pays special attention to improving the quality of life in rural areas and the diversification of the rural economy because local communities in Romania have experienced some changes in this period, while accessing EAFRD funds contributed to increased regional disparities between developed and poor areas.

  13. Local and regional interactions between air quality and climate in New Delhi- A sector based analysis

    Science.gov (United States)

    Marrapu, Pallavi

    Deteriorating air quality is one of the major problems faced worldwide and in particular in Asia. The world's most polluted megacities are located in Asia highlighting the urgent need for efforts to improve the air quality. New Delhi (India), one of the world's most polluted cities, was the host of the Common Wealth Games during the period of 4-14 October 2010. This high profile event provided a good opportunity to accelerate efforts to improve air quality. Computational advances now allow air quality forecast models to fully couple the meteorology with chemical constituents within a unified modeling system that allows two-way interactions. The WRF-Chem model is used to simulate air quality in New Delhi. The thesis focuses on evaluating air quality and meteorology feedbacks. Four nested domains ranging from South Asia, Northern India, NCR Delhi and Delhi city at 45km, 15km, 5km and 1.67km resolution for a period of 20 day (26th Sep--15th Oct, 2010) are used in the study. The predicted mean surface concentrations of various pollutants show similar spatial distributions with peak values in the middle of the domain reflecting the traffic and population patterns in the city. Along with these activities, construction dust and industrial emissions contribute to high levels of criteria pollutants. The study evaluates the WRF-Chem capabilities using a new emission inventory developed over Delhi at a fine resolution of 1.67km and evaluating the results with observational data from 11 monitoring sties placed at various Game venues. The contribution of emission sectors including transportation, power, industry, and domestic to pollutant concentrations at targeted regions are studied and the results show that transportation and domestic sector are the major contributors to the pollution levels in Delhi, followed by industry. Apart from these sectors, emissions outside of Delhi contribute 20-50% to surface concentrations depending on the species. This indicates that pollution

  14. Development of a Florida Coastal Mapping Program Through Local and Regional Coordination

    Science.gov (United States)

    Hapke, C. J.; Kramer, P. A.; Fetherston-Resch, E.; Baumstark, R.

    2017-12-01

    The State of Florida has the longest coastline in the contiguous United States (2,170 km). The coastal zone is heavily populated and contains 1,900 km of sandy beaches that support economically important recreation and tourism. Florida's waters also host important marine mineral resources, unique ecosystems, and the largest number of recreational boats and saltwater fishermen in the country. There is increasing need and demand for high resolution data of the coast and adjacent seafloor for resource and habitat mapping, understanding coastal vulnerability, evaluating performance of restoration projects, and many other coastal and marine spatial planning efforts. The Florida Coastal Mapping Program (FCMP), initiated in 2017 as a regional collaboration between four federal and three state agencies, has goals of establishing the priorities for high resolution seafloor mapping of Florida's coastal environment, and developing a strategy for leveraging funds to support mapping priorities set by stakeholders. We began by creating a comprehensive digital inventory of existing data (collected by government, the private sector, and academia) from 1 kilometer inland to the 200 meter isobath for a statewide geospatial database and gap analysis. Data types include coastal topography, bathymetry, and acoustic data such as sidescan sonar and subbottom profiles. Next, we will develop appropriate proposals and legislative budget requests in response to opportunities to collect priority data in high priority areas. Data collection will be undertaken by a combination of state and federal agencies. The FCMP effort will provide the critical baseline information that is required for characterizing changes to fragile ecosystems, assessing marine resources, and forecasting the impacts on coastal infrastructure and recreational beaches from future storms and sea-level rise.

  15. Regional localization of suspensor mRNAs during early embryo development.

    Science.gov (United States)

    Weterings, K; Apuya, N R; Bi, Y; Fischer, R L; Harada, J J; Goldberg, R B

    2001-11-01

    We investigated gene activity within the giant embryos of the scarlet runner bean (Phaseolus coccineus) to gain understanding of the processes by which the apical and basal cells become specified to follow different developmental pathways after division of the zygote. We identified two mRNAs, designated G564 and C541, that accumulate specifically within the suspensor of globular-stage embryos. G564 mRNA accumulates uniformly throughout the suspensor, whereas C541 mRNA accumulates to a higher level within the large basal cells of the suspensor that anchor the embryo to the surrounding seed tissue. Both G564 and C541 mRNAs begin to accumulate shortly after fertilization and are present within the two basal cells of embryos at the four-cell stage. In contrast, at the same stage, these mRNAs are not detectable within the two descendants of the apical cell. Nor are they detectable within cells of the embryo sac before fertilization, including the egg cell. We used a G564/beta-glucuronidase reporter gene to show that the G564 promoter is activated specifically within the basal region and suspensor of preglobular tobacco embryos. Analysis of the G564 promoter identified a sequence domain required for transcription within the suspensor that contains several copies of a conserved motif. These results show that derivatives of the apical and basal cells transcribe different genes as early as the four-cell stage of embryo development and suggest that the apical and basal cells are specified at the molecular level after division of the zygote.

  16. Regional Localization of Suspensor mRNAs during Early Embryo Development

    Science.gov (United States)

    Weterings, Koen; Apuya, Nestor R.; Bi, Yuping; Fischer, Robert L.; Harada, John J.; Goldberg, Robert B.

    2001-01-01

    We investigated gene activity within the giant embryos of the scarlet runner bean (Phaseolus coccineus) to gain understanding of the processes by which the apical and basal cells become specified to follow different developmental pathways after division of the zygote. We identified two mRNAs, designated G564 and C541, that accumulate specifically within the suspensor of globular-stage embryos. G564 mRNA accumulates uniformly throughout the suspensor, whereas C541 mRNA accumulates to a higher level within the large basal cells of the suspensor that anchor the embryo to the surrounding seed tissue. Both G564 and C541 mRNAs begin to accumulate shortly after fertilization and are present within the two basal cells of embryos at the four-cell stage. In contrast, at the same stage, these mRNAs are not detectable within the two descendants of the apical cell. Nor are they detectable within cells of the embryo sac before fertilization, including the egg cell. We used a G564/β-glucuronidase reporter gene to show that the G564 promoter is activated specifically within the basal region and suspensor of preglobular tobacco embryos. Analysis of the G564 promoter identified a sequence domain required for transcription within the suspensor that contains several copies of a conserved motif. These results show that derivatives of the apical and basal cells transcribe different genes as early as the four-cell stage of embryo development and suggest that the apical and basal cells are specified at the molecular level after division of the zygote. PMID:11701878

  17. Local versus regional active stress field in 5900m San Gregorio Magno 1 well (southern Apennines, Italy).

    Science.gov (United States)

    Pierdominici, S.; Montone, P.; Mariucci, M. T.

    2009-04-01

    The aim of this work is to characterize the local stress field in a peculiar sector of the southern Apennines by analyzing borehole breakouts, fractures and logging data along the San Gregorio Magno 1 deep well, and to compare the achieved stress field with the regional one. The study area is characterized by diffuse low-Magnitude seismicity, although in historical times it has been repeatedly struck by moderate to large earthquakes. We have analyzed in detail the 5900m San Gregorio Magno 1 well drilled in 1996-97 by ENI S.p.A. and located very close (1.3 km away) to the Irpinia Fault. This fault was responsible of the strongest earthquake happened in this area, the 23rd November 1980 M6.9 earthquake that produced the first unequivocal historical surface faulting ever documented in Italy. The mainshock enucleated on a fault 38 km-long with a strike of 308° and 60-70° northeast-dipping, consistent with a NE-SW T-axis and a normal faulting tectonic regime. Borehole breakouts, active faults and focal mechanism solutions have allowed to define the present-day stress along and around the San Gregorio Magno 1 well and other analysis (logging data) to discriminate the presence of fracture zones and/or faults at depth. We have considered data from 1200m to the bottom of San Gregorio Magno 1 well. Our analysis of stress-induced wellbore breakouts shows an inhomogeneous direction of minimum horizontal stress (N359+-31°) orientation along the well. This direction is moderately consistent with the Shmin-trend determined from breakouts in other wells in this region and also with the regional active stress field inferred from active faults and earthquake focal plane solutions (N44 Shmin oriented). For this reason we have computed for each breakout zone the difference between the local trend and the regional one; comparing these breakout rotations with the spikes or changing trend of logs we have identified possible fractures or faults at different depths. We have correlated

  18. Managed Aquifer Recharge: from Local Research and Experiences to Regional Aquifer Storage and Recovery

    Science.gov (United States)

    Hendriks, D.; Faneca, M.; Oude Essink, G.; van Baaren, E.; Stuurman, R.; Delsman, J. R.; van Kempen, C.; de Louw, P.

    2016-12-01

    Many areas in the world experience periodic water shortages due to meteorological drought, salt water intrusion or over-exploitation of the water resources. Recently, it was established that the depletion of aquifers in many areas of the world is in an advanced state (Gleeson et al, 2012). This poses enormous challenges as 2.5 billion people and many companies depend on groundwater now and in the future (UN, 2015; ESG, 2016). A solution to increase robustness of water systems and prevent water shortage is subsurface storage of water during wet periods using Managed Aquifer Research (MAR). In addition to mitigation of water shortage, MAR can also reduce the occurrence and degree of flooding. Here, we present an overview of Deltares MAR expertise and available tools for up-scaling MAR. Deltares has experience with both research and implementation of MAR in different parts of the world under various hydro(geo)logical, climatic and socio-economic conditions. Various MAR techniques were assessed/tested in coastal areas of the Netherlands, Spain, New York, New Orleans and in Bangladesh. In some of these areas specific groundwater shortage related issues occur, such as salt water intrusion or subsidence. In Singapore, monitoring campaigns and modeling were done to design MAR by infiltration of water in over-exploited aquifers. In Abu Dhabi, geophysical methods were used to detect the optimal conditions for MAR systems. To effectively increase the robustness of groundwater systems up-scaling of MAR is required. For this purpose, Deltares developed tools that provide insight in the potential demand, possibilities and effectiveness of MAR at larger scales. The Quick scan tool for Fresh Groundwater Buffering provides insight on regional to national scale and is based on GIS-information of water demand, water resources, and subsurface properties. This quick scan tool has been applied for Mozambique, Kenya, India and Bangladesh. The Fresh Water Optimizer assesses the

  19. Evaluation of hydrophilic permeant transport parameters in the localized and non-localized transport regions of skin treated simultaneously with low-frequency ultrasound and sodium lauryl sulfate.

    Science.gov (United States)

    Kushner, Joseph; Blankschtein, Daniel; Langer, Robert

    2008-02-01

    The porosity (epsilon), the tortuosity (tau), and the hindrance factor (H) of the aqueous pore channels located in the localized transport regions (LTRs) and the non-LTRs formed in skin treated simultaneously with low-frequency ultrasound (US) and the surfactant sodium lauryl sulfate (SLS), were evaluated for the delivery of four hydrophilic permeants (urea, mannitol, raffinose, and inulin) by analyzing dual-radiolabeled diffusion masking experiments for three different idealized cases of the aqueous pore pathway hypothesis. When epsilon and tau were assumed to be independent of the permeant radius, H was found to be statistically larger in the LTRs than in the non-LTRs. When a distribution of pore radii was assumed to exist in the skin, no statistical differences in epsilon, tau, and H were observed due to the large variation in the pore radii distribution shape parameter (3 A to infinity). When infinitely large aqueous pores were assumed to exist in the skin, epsilon was found to be 3-8-fold greater in the LTRs than in the non-LTRs, while little difference was observed in the LTRs and in the non-LTRs for tau. This last result suggests that the efficacy of US/SLS treatment may be enhanced by increasing the porosity of the non-LTRs.

  20. Assessment of global and local region-based bilateral mammographic feature asymmetry to predict short-term breast cancer risk

    Science.gov (United States)

    Li, Yane; Fan, Ming; Cheng, Hu; Zhang, Peng; Zheng, Bin; Li, Lihua

    2018-01-01

    This study aims to develop and test a new imaging marker-based short-term breast cancer risk prediction model. An age-matched dataset of 566 screening mammography cases was used. All ‘prior’ images acquired in the two screening series were negative, while in the ‘current’ screening images, 283 cases were positive for cancer and 283 cases remained negative. For each case, two bilateral cranio-caudal view mammograms acquired from the ‘prior’ negative screenings were selected and processed by a computer-aided image processing scheme, which segmented the entire breast area into nine strip-based local regions, extracted the element regions using difference of Gaussian filters, and computed both global- and local-based bilateral asymmetrical image features. An initial feature pool included 190 features related to the spatial distribution and structural similarity of grayscale values, as well as of the magnitude and phase responses of multidirectional Gabor filters. Next, a short-term breast cancer risk prediction model based on a generalized linear model was built using an embedded stepwise regression analysis method to select features and a leave-one-case-out cross-validation method to predict the likelihood of each woman having image-detectable cancer in the next sequential mammography screening. The area under the receiver operating characteristic curve (AUC) values significantly increased from 0.5863  ±  0.0237 to 0.6870  ±  0.0220 when the model trained by the image features extracted from the global regions and by the features extracted from both the global and the matched local regions (p  =  0.0001). The odds ratio values monotonically increased from 1.00-8.11 with a significantly increasing trend in slope (p  =  0.0028) as the model-generated risk score increased. In addition, the AUC values were 0.6555  ±  0.0437, 0.6958  ±  0.0290, and 0.7054  ±  0.0529 for the three age groups of 37

  1. P1-27: Localizing Regions Activated by Surface Gloss in Macaque Visual Cortex by fMRI

    Directory of Open Access Journals (Sweden)

    Gouki Okazawa

    2012-10-01

    Full Text Available Surface properties of objects such as gloss provide important information about the states or materials of objects in our visual experiences. Previous studies have shown that there are cortical regions responding to shapes, colors, faces etc. in the macaque visual cortex. However, we still lack the information about where the surface properties are processed in the macaque visual cortex. In this study, we examined whether there are regions activated by surface gloss, an important surface property, in the macaque visual cortex by using functional magnetic resonance imaging (fMRI. We trained two monkeys to fixate on a small spot on the screen in MRI scanner, while the images of glossy and matte objects were presented. As a control condition for low-level image features, such as spatial frequency or luminance contrast, we generated scrambled images by locally randomizing the luminance phases of images using wavelet filters. By contrasting the responses to glossy images to those to matte and scrambled images, we found the activation in wide regions along the ventral visual pathway including V1, V2, V3, V4, and the posterior part of the inferior temporal (IT cortex. In one monkey, we also found the activations in the central part of IT cortex. In another control experiment, we manipulated the image contrasts and found that the responses in these regions cannot be explained simply by the image contrasts. These results suggest that surface gloss is processed along the ventral pathway and, in the IT cortex there are distinct regions processing surface gloss.

  2. Analysis of Thermal Structure of Arctic Lakes at Local and Regional Scales Using in Situ and Multidate Landsat-8 Data

    Science.gov (United States)

    Huang, Yan; Liu, Hongxing; Hinkel, Kenneth; Yu, Bailang; Beck, Richard; Wu, Jianping

    2017-11-01

    The Arctic coastal plain is covered with numerous thermokarst lakes. These lakes are closely linked to climate and environmental change through their heat and water budgets. We examined the intralake thermal structure at the local scale and investigated the water temperature pattern of lakes at the regional scale by utilizing extensive in situ measurements and multidate Landsat-8 remote sensing data. Our analysis indicates that the lake skin temperatures derived from satellite thermal sensors during most of the ice-free summer period effectively represent the lake bulk temperature because the lakes are typically well-mixed and without significant vertical stratification. With the relatively high-resolution Landsat-8 thermal data, we were able to quantitatively examine intralake lateral temperature differences and gradients in relation to geographical location, topography, meteorological factors, and lake morphometry for the first time. Our results suggest that wind speed and direction not only control the vertical stratification but also influences lateral differences and gradients of lake surface temperature. Wind can considerably reduce the intralake temperature gradient. Interestingly, we found that geographical location (latitude, longitude, distance to the ocean) and lake morphometry (surface size, depth, volume) not only control lake temperature regionally but also affect the lateral temperature gradient and homogeneity level within each individual lake. For the Arctic coastal plain, at regional scales, inland and southern lakes tend to have larger horizontal temperature differences and gradients compared to coastal and northern lakes. At local scales, large and shallow lakes tend to have large lateral temperature differences relative to small and deep lakes.

  3. Knowledge and perspectives of female genital cutting among the local religious leaders in Erbil governorate, Iraqi Kurdistan region.

    Science.gov (United States)

    Ahmed, Hamdia M; Kareem, Mosleh S; Shabila, Nazar P; Mzori, Barzhang Q

    2018-03-07

    Religious leaders are one of the key actors in the issue of female genital cutting (FGC) due to the influential position they have in the community and the frequent association of FGC with the religion. This study aimed to assess the knowledge and perspectives of the local religious leaders in Erbil governorate, Iraqi Kurdistan Region about different aspects of FGC. In-depth interviews were conducted with a sample of 29 local religious leaders. A semi-structured questionnaire was used that included questions about their knowledge, understanding, and perspectives on different aspects of FGC such as the reasons for practicing it, their contact and communication with the community regarding the practice and perspectives about banning the practice by law. Participants believed that FGC is useful for reducing or regulating the sexual desire of women to prevent adultery and engagement in pre and extramarital sexual relations and to enhance hygiene of women. They indicated that there is no any risk in doing FGC if there is no excessive cut. Most participants indicated that FGC is attributed to the religion and some considered it a tradition mixed with the religion. People rarely ask the advice of the religious leaders regarding FGC, but they frequently complain about the effects of the practice. Participants did not support having a law to ban FGC either because they thought it would be against the religion's advice on FGC or it will not work. The local religious leaders lack adequate knowledge about different aspects of FGC particularly the health consequences. There are different and disputing viewpoints about the reasons for practicing FGC, and there is poor support for having a law banning the practice. There is an essential need for enhancing the knowledge of the local religious leaders regarding FGC and its adverse effects on the women's health.

  4. Increased fire frequency promotes stronger spatial genetic structure and natural selection at regional and local scales in Pinus halepensis Mill.

    Science.gov (United States)

    Budde, Katharina B; González-Martínez, Santiago C; Navascués, Miguel; Burgarella, Concetta; Mosca, Elena; Lorenzo, Zaida; Zabal-Aguirre, Mario; Vendramin, Giovanni G; Verdú, Miguel; Pausas, Juli G; Heuertz, Myriam

    2017-04-01

    The recurrence of wildfires is predicted to increase due to global climate change, resulting in severe impacts on biodiversity and ecosystem functioning. Recurrent fires can drive plant adaptation and reduce genetic diversity; however, the underlying population genetic processes have not been studied in detail. In this study, the neutral and adaptive evolutionary effects of contrasting fire regimes were examined in the keystone tree species Pinus halepensis Mill. (Aleppo pine), a fire-adapted conifer. The genetic diversity, demographic history and spatial genetic structure were assessed at local (within-population) and regional scales for populations exposed to different crown fire frequencies. Eight natural P. halepensis stands were sampled in the east of the Iberian Peninsula, five of them in a region exposed to frequent crown fires (HiFi) and three of them in an adjacent region with a low frequency of crown fires (LoFi). Samples were genotyped at nine neutral simple sequence repeats (SSRs) and at 251 single nucleotide polymorphisms (SNPs) from coding regions, some of them potentially important for fire adaptation. Fire regime had no effects on genetic diversity or demographic history. Three high-differentiation outlier SNPs were identified between HiFi and LoFi stands, suggesting fire-related selection at the regional scale. At the local scale, fine-scale spatial genetic structure (SGS) was overall weak as expected for a wind-pollinated and wind-dispersed tree species. HiFi stands displayed a stronger SGS than LoFi stands at SNPs, which probably reflected the simultaneous post-fire recruitment of co-dispersed related seeds. SNPs with exceptionally strong SGS, a proxy for microenvironmental selection, were only reliably identified under the HiFi regime. An increasing fire frequency as predicted due to global change can promote increased SGS with stronger family structures and alter natural selection in P. halepensis and in plants with similar life history traits

  5. Joint Inversion Of Local And Teleseismic Data For The Crust And Mantle Structure Of The Chinese Capital Region

    Science.gov (United States)

    Huang, J.; Zhao, D.

    2004-12-01

    The Chinese Capital (Beijing) region is located in the intersection of the Yanshan and Taihangshan uplifts in North China. It is one of the regions with the strongest continental earthquakes in the world such as the 1976 Tangshan earthquake (M 7.8) which killed 240,000 people. Hence the determination of the crust and mantle structure of this region is very important for understanding the regional tectonics and for the reduction of earthquake hazards. Since October 2001 a new digital seismic network with 107 stations has been installed in this region, which is the most advanced and densest regional digital seismic network in mainland China. In this study we used 48750 P-wave arrival times from 2973 local events and 12249 travel time residuals from 234 teleseismic events recorded by this new digital seismic network. We adopted the local and teleseismic joint inversion approach by Zhao et al. [1994] and obtained a high-resolution three-dimensional (3-D) P-wave velocity model of the crust and mantle down to a depth of 1000 km. The resolution is 50 km in the horizontal direction, and in depth it is 4-17 km in the crust and 30-50 km in the mantle. The complex morphology of the Conrad and Moho discontinuities was taken into account in the tomographic inversions. Our 3-D velocity model provides new insights into the geological structure and tectonics of this region. The velocity images of the upper crust reflect well the surface geological, topographic and lithological features. In the North China Basin, the depression and uplift areas are imaged as slow and fast velocity belts oriented in NE-SW direction. The trend of velocity anomalies is the same as that of major faults and tectonics. Paleozoic strata and Pre-Cambrian basement rocks outcrop widely in the Taihangshan and Yanshan uplift areas, which exhibit strong and broad high-velocity(high-V) anomalies in our tomographic images, while the Quaternary intermountain basins show up as small low-velocity(low-V) anomalies

  6. Identification and analysis of local and regional impacts from the introduction of biodiesel production in the state of Piaui

    International Nuclear Information System (INIS)

    Benedetti Santos, Omar Inacio; Rathmann, Regis

    2009-01-01

    The recent moves towards the insertion of biofuels in the energy matrix of a number of countries are opening new prospects for agricultural production and for agroindustrial chains. The emergence of this new productive base raises new research issues: in what circumstances are the structuring, organization and implementation of these biodiesel productive chains taking place in Brazil? What are the effects of biodiesel production on local economies? Hence, the central objective of this study is identifying their economic and social impacts at the regions where they are installed. The analytical structure was constructed based on theories of regional and spatial economy: location coefficient, shift-share, theories of industrial location. A preliminary analysis identified that a biodiesel productive arrangement is emerging in the State of Piaui, Northeastern Brazil, with the purpose of stimulating regional development using alternative oil-bearing crops. However, the agricultural project in the town of Canto do Buriti/PI has faced problems of both a cultural and productive nature. Preliminary findings reveal productive, organizational, managerial and governance related difficulties and challenges that need to be faced when establishing a new productive base in a location that up to that point lacks a productive tradition.

  7. Local and regional estimation of floods in the Timis and Bega hydrographic basins: application of converging QDF model concept

    International Nuclear Information System (INIS)

    Mic, Rodica; Gaida, Gilles

    2004-01-01

    A flow-duration-frequency regionalisation is carried out on the Timis and Bega rivers sub-catchments in the west of Romania. This regionalisation concerns 28 sub-catchments having about thirty years of stream flow measurements (daily flow, instantaneous flood peaks and hydrographs). This work about the floods regionalisation is realized in the framework of the European project Riverlife. The regional model will allow defining the hydrographs of project necessary for the hydraulic modelling. This hydraulic project is necessary in order to protect Timisoara - city against the floods. The method uses the hypotheses of the converging QdF model and adapts the index flood method for obtaining a regional dimensionless distribution. For long return periods, this approach uses the GRADEX method, which extrapolates discharge distributions according to the rainfall distributions. The dimensionless regional QdF model needs two local descriptors of target site to be denormed: QIXA10 and Δ: the annual maximum instantaneous flow with a 10% probability to be exceeded (the 10-year peak flood) and a characteristic duration, respectively. For these both variables, the relations obtained by regression are presented, involving morphologic and climatic basin characteristics.(Author)

  8. Localization of a region in the fusion protein of avian metapneumovirus that modulates cell-cell fusion.

    Science.gov (United States)

    Wei, Yongwei; Feng, Kurtis; Yao, Xiangjie; Cai, Hui; Li, Junan; Mirza, Anne M; Iorio, Ronald M; Li, Jianrong

    2012-11-01

    The genus Metapneumovirus within the subfamily Pneumovirinae of the family Paramyxoviridae includes two members, human metapneumovirus (hMPV) and avian metapneumovirus (aMPV), causing respiratory tract infections in humans and birds, respectively. Paramyxoviruses enter host cells by fusing the viral envelope with a host cell membrane. Membrane fusion of hMPV appears to be unique, in that fusion of some hMPV strains requires low pH. Here, we show that the fusion (F) proteins of aMPV promote fusion in the absence of the attachment protein and low pH is not required. Furthermore, there are notable differences in cell-cell fusion among aMPV subtypes. Trypsin was required for cell-cell fusion induced by subtype B but not subtypes A and C. The F protein of aMPV subtype A was highly fusogenic, whereas those from subtypes B and C were not. By construction and evaluation of chimeric F proteins composed of domains from the F proteins of subtypes A and B, we localized a region composed of amino acid residues 170 to 338 in the F protein that is responsible for the hyperfusogenic phenotype of the F from subtype A. Further mutagenesis analysis revealed that residues R295, G297, and K323 in this region collectively contributed to the hyperfusogenicity. Taken together, we have identified a region in the aMPV F protein that modulates the extent of membrane fusion. A model for fusion consistent with these data is presented.

  9. Local and regional effects of large scale atmospheric circulation patterns on winter wind power output in Western Europe

    Science.gov (United States)

    Zubiate, Laura; McDermott, Frank; Sweeney, Conor; O'Malley, Mark

    2014-05-01

    Recent studies (Brayshaw, 2009, Garcia-Bustamante, 2010, Garcia-Bustamante, 2013) have drawn attention to the sensitivity of wind speed distributions and likely wind energy power output in Western Europe to changes in low-frequency, large scale atmospheric circulation patterns such as the North Atlantic Oscillation (NAO). Wind speed variations and directional shifts as a function of the NAO state can be larger or smaller depending on the North Atlantic region that is considered. Wind speeds in Ireland and the UK for example are approximately 20 % higher during NAO + phases, and up to 30 % lower during NAO - phases relative to the long-term (30 year) climatological means. By contrast, in southern Europe, wind speeds are 15 % lower than average during NAO + phases and 15 % higher than average during NAO - phases. Crucially however, some regions such as Brittany in N.W. France have been identified in which there is negligible variability in wind speeds as a function of the NAO phase, as observed in the ERA-Interim 0.5 degree gridded reanalysis database. However, the magnitude of these effects on wind conditions is temporally and spatially non-stationary. As described by Comas-Bru and McDermott (2013) for temperature and precipitation, such non-stationarity is caused by the influence of two other patterns, the East Atlantic pattern, (EA), and the Scandinavian pattern, (SCA), which modulate the position of the NAO dipole. This phenomenon has also implications for wind speeds and directions, which has been assessed using the ERA-Interim reanalysis dataset and the indices obtained from the PC analysis of sea level pressure over the Atlantic region. In order to study the implications for power production, the interaction of the NAO and the other teleconnection patterns with local topography was also analysed, as well as how these interactions ultimately translate into wind power output. The objective is to have a better defined relationship between wind speed and power

  10. From community-based pilot testing to region-wide systems change: lessons from a local quality improvement collaborative.

    Science.gov (United States)

    Keyser, Donna J; Pincus, Harold Alan

    2010-01-01

    A community-based collaborative conducted a 2-year pilot study to inform efforts for improving maternal and child health care practice and policy in Allegheny County, Pennsylvania. (1) To test whether three small-scale versions of an evidence-based, systems improvement approach would be workable in local community settings and (2) to identify specific policy/infrastructure reforms for sustaining improvements. A mixed methods approach was used, including quantitative performance measurement supplemented with qualitative data about factors related to outcomes of interest, as well as key stakeholder interviews and a literature review/Internet search. Quantitative performance results varied; qualitative data revealed critical factors for the success and failure of the practices tested. Policy/infrastructure recommendations were developed to address specific practice barriers. This information was important for designing a region-wide quality improvement initiative focused on maternal depression. The processes and outcomes provide valuable insights for other communities interested in conducting similar quality improvement initiatives.

  11. Investigating correlations of local seismicty with anomalous geoelectrical, hydrogeological and geochemical signals jointly recorded in Basilicata Region (Southern Italy

    Directory of Open Access Journals (Sweden)

    M. Mucciarelli

    2007-06-01

    Full Text Available This paper presents the preliminary results analysing the correlation between local seismicity and geoelectrical, hydrogeological and geochemical signals concomitantly recorded in Basilicata Region, one of the most seismically active areas in Southern Italy. The signals were recorded by two stations: Tito and Tramutola. Tito station measures vertically the Self-Potential field (SP by an array of five no-polarizable electrodes equally spaced with the common electrode at 20 m depth as well as water-level, water-temperature and electrical-conductivity. Tramutola station measures self-potential signals in soil surface, gas flow and water temperature in a thermal-water well, as well as atmospheric barometric pressure and ambient temperature. Correlations were found between the sharp variability of the signals recorded by both stations and the seismic sequence that occurred on September 3 to 4, 2004, allowing us to link these anomalies with the tectonic evolution of the investigated area.

  12. Hydrogeological modelling of the eastern region of Areco river locally detailed on Atucha I and II nuclear power plants area

    International Nuclear Information System (INIS)

    Grattone, Natalia I.; Fuentes, Nestor O.

    2009-01-01

    Water flow behaviour of Pampeano aquifer was modeled using Visual Mod-flow software Package 2.8.1 with the assumption of a free aquifer, within the region of the Areco river and extending to the rivers of 'Canada Honda' and 'de la Cruz'. Steady state regime was simulated and grid refinement allows obtaining locally detailed calculation in the area of Atucha I and II Nuclear power plants, in order to compute unsteady situations as the consequence of water flow variations from and to the aquifer, enabling the model to study the movement of possible contaminant particles in the hydrogeologic system. In this work the effects of rivers action, the recharge conditions and the flow lines are analyzed, taking always into account the range of reliability of obtained results, considering the incidence of uncertainties introduced by data input system, the estimates and interpolation of parameters used. (author)

  13. Local diagnostic reference levels, approaches and compare the values in the South Bohemia Region in view of radiation protection inspector

    International Nuclear Information System (INIS)

    Zemanova, E.

    2014-01-01

    This paper compares the value of local diagnostic reference levels(the LDRL)in health facilities of the South Bohemia Region. The work is motivated by questions of licensees, who would like to know their position in terms of the LDRL compared to other workplaces. Also by the activity of the inspector who can identify the problematic workplaces, where is necessary to increase attention to optimization, exposure, or justification. In connection with the ongoing internal audits in licensee workplaces the information about the status of the LDRL among others is current, motivating licensee to changes, optimization and verification of compliance with the recommendation of the National radiological standard of Ministry of Health (author)

  14. Acute esophagitis for patients with local-regional advanced non small cell lung cancer treated with concurrent chemoradiotherapy

    DEFF Research Database (Denmark)

    Pan, Yi; Brink, Carsten; Knap, Marianne

    2016-01-01

    PURPOSE: Esophagitis is common in patients treated with definitive radiotherapy for local-regional advanced non small cell lung cancer (NSCLC). The purpose of this study was to estimate the dose-effect relationship using clinical and dosimetric parameters in patients receiving intensity modulated...... significantly associated with esophagitis. The two models using the relative esophagus volume irradiated above 40Gy (V40, OR=2.18/10% volume) or the length of esophagus irradiated above 40Gy (L40, OR=4.03/5cm) were optimal. The upper part of esophagus was more sensitive and females experienced more toxicity...... than men. CONCLUSION: V40 and L40 were most effective dosimetric predictors of grade ⩾2 esophagitis. The upper part of esophagus was more sensitive....

  15. A local region of interest image reconstruction via filtered backprojection for fan-beam differential phase-contrast computed tomography

    International Nuclear Information System (INIS)

    Qi Zhihua; Chen Guanghong

    2007-01-01

    Recently, x-ray differential phase contrast computed tomography (DPC-CT) has been experimentally implemented using a conventional source combined with several gratings. Images were reconstructed using a parallel-beam reconstruction formula. However, parallel-beam reconstruction formulae are not directly applicable for a large image object where the parallel-beam approximation fails. In this note, we present a new image reconstruction formula for fan-beam DPC-CT. There are two major features in this algorithm: (1) it enables the reconstruction of a local region of interest (ROI) using data acquired from an angular interval shorter than 180 0 + fan angle and (2) it still preserves the filtered backprojection structure. Numerical simulations have been conducted to validate the image reconstruction algorithm. (note)

  16. Use of microwave remote sensing data to monitor spatio temporal characteristics of surface soil moisture at local and regional scales

    Directory of Open Access Journals (Sweden)

    A. Löw

    2005-01-01

    Full Text Available Hydrologic processes, such as runoff production or evapotranspiration, largely depend on the variation of soil moisture and its spatial pattern. The interaction of electromagnetic waves with the land surface can be dependant on the water content of the uppermost soil layer. Especially in the microwave domain of the electromagnetic spectrum, this is the case. New sensors as e.g. ENVISAT ASAR, allow for frequent, synoptically and homogeneous image acquisitions over larger areas. Parameter inversion models are therefore developed to derive bio- and geophysical parameters from the image products. The paper presents a soil moisture inversion model for ENVISAT ASAR data for local and regional scale applications. The model is validated against in situ soil moisture measurements. The various sources of uncertainties, being related to the inversion process are assessed and quantified.

  17. A fresh look at road salt: aquatic toxicity and water-quality impacts on local, regional, and national scales.

    Science.gov (United States)

    Corsi, Steven R; Graczyk, David J; Geis, Steven W; Booth, Nathaniel L; Richards, Kevin D

    2010-10-01

    A new perspective on the severity of aquatic toxicity impact of road salt was gained by a focused research effort directed at winter runoff periods. Dramatic impacts were observed on local, regional, and national scales. Locally, samples from 7 of 13 Milwaukee, Wisconsin area streams exhibited toxicity in Ceriodaphnia dubia and Pimephales promelas bioassays during road-salt runoff. Another Milwaukee stream was sampled from 1996 to 2008 with 72% of 37 samples exhibiting toxicity in chronic bioassays and 43% in acute bioassays. The maximum chloride concentration was 7730 mg/L. Regionally, in southeast Wisconsin, continuous specific conductance was monitored as a chloride surrogate in 11 watersheds with urban land use from 6.0 to 100%. Elevated specific conductance was observed between November and April at all sites, with continuing effects between May and October at sites with the highest specific conductance. Specific conductance was measured as high as 30,800 μS/cm (Cl = 11,200 mg/L). Chloride concentrations exceeded U.S. Environmental Protection Agency (USEPA) acute (860 mg/L) and chronic (230 mg/L) water-quality criteria at 55 and 100% of monitored sites, respectively. Nationally, U.S. Geological Survey historical data were examined for 13 northern and 4 southern metropolitan areas. Chloride concentrations exceeded USEPA water-quality criteria at 55% (chronic) and 25% (acute) of the 168 monitoring locations in northern metropolitan areas from November to April. Only 16% (chronic) and 1% (acute) of sites exceeded criteria from May to October. At southern sites, very few samples exceeded chronic water-quality criteria, and no samples exceeded acute criteria.

  18. Local processes and regional patterns - Interpreting a multi-decadal altimetry record of Greenland Ice Sheet changes

    Science.gov (United States)

    Csatho, B. M.; Schenk, A. F.; Babonis, G. S.; van den Broeke, M. R.; Kuipers Munneke, P.; van der Veen, C. J.; Khan, S. A.; Porter, D. F.

    2016-12-01

    This study presents a new, comprehensive reconstruction of Greenland Ice Sheet elevation changes, generated using the Surface Elevation And Change detection (SERAC) approach. 35-year long elevation-change time series (1980-2015) were obtained at more than 150,000 locations from observations acquired by NASA's airborne and spaceborne laser altimeters (ATM, LVIS, ICESat), PROMICE laser altimetry data (2007-2011) and a DEM covering the ice sheet margin derived from stereo aerial photographs (1970s-80s). After removing the effect of Glacial Isostatic Adjustment (GIA) and the elastic crustal response to changes in ice loading, the time series were partitioned into changes due to surface processes and ice dynamics and then converted into mass change histories. Using gridded products, we examined ice sheet elevation, and mass change patterns, and compared them with other estimates at different scales from individual outlet glaciers through large drainage basins, on to the entire ice sheet. Both the SERAC time series and the grids derived from these time series revealed significant spatial and temporal variations of dynamic mass loss and widespread intermittent thinning, indicating the complexity of ice sheet response to climate forcing. To investigate the regional and local controls of ice dynamics, we examined thickness change time series near outlet glacier grounding lines. Changes on most outlet glaciers were consistent with one or more episodes of dynamic thinning that propagates upstream from the glacier terminus. The spatial pattern of the onset, duration, and termination of these dynamic thinning events suggest a regional control, such as warming ocean and air temperatures. However, the intricate spatiotemporal pattern of dynamic thickness change suggests that, regardless of the forcing responsible for initial glacier acceleration and thinning, the response of individual glaciers is modulated by local conditions. We use statistical methods, such as principal

  19. Long-term visibility variation in Athens (1931–2013: a proxy for local and regional atmospheric aerosol loads

    Directory of Open Access Journals (Sweden)

    D. Founda

    2016-09-01

    Full Text Available This study explores the interdecadal variability and trends of surface horizontal visibility at the urban area of Athens from 1931 to 2013, using the historical archives of the National Observatory of Athens (NOA. A prominent deterioration of visibility in the city was detected, with the long-term linear trend amounting to −2.8 km decade−1 (p < 0.001, over the entire study period. This was not accompanied by any significant trend in relative humidity or precipitation over the same period. A slight recovery of visibility levels seems to be established in the recent decade (2004–2013. It was found that very good visibility (>  20 km occurred at a frequency of 34 % before the 1950s, while this percentage drops to just 2 % during the decade 2004–2013. The rapid impairment of the visual air quality in Athens around the 1950s points to the increased levels of air pollution on a local and/or regional scale, related to high urbanization rates and/or increased anthropogenic emissions on a global scale at that period. Visibility was found to be negatively/positively correlated with relative humidity/wind speed, the correlation being statistically valid at certain periods. Wind regime and mainly wind direction and corresponding air mass origin were found to highly control visibility levels in Athens. The comparison of visibility variation in Athens and at a non-urban reference site on Crete island revealed similar negative trends over the common period of observations. This suggests that apart local sources, visibility in Athens is highly determined by aerosol load of regional origin. AVHRR and MODIS satellite-derived aerosol optical depth (AOD retrievals over Athens and surface measurements of PM10 confirmed the relation of visibility to aerosol load.

  20. The Impact of a Potential Shale Gas Development in Germany and the United Kingdom on Local and Regional Air Quality

    Science.gov (United States)

    Weger, L.; Lupascu, A.; Cremonese, L.; Butler, T. M.

    2017-12-01

    Numerous countries in Europe that possess domestic shale gas reserves are considering exploiting this unconventional gas resource as part of their energy transition agenda. While natural gas generates less CO2 emissions upon combustion compared to coal or oil, making it attractive as a bridge in the transition from fossil fuels to renewables, production of shale gas leads to emissions of CH4 and air pollutants such as NOx, VOCs and PM. These gases in turn influence the climate as well as air quality. In this study, we investigate the impact of a potential shale gas development in Germany and the United Kingdom on local and regional air quality. This work builds on our previous study in which we constructed emissions scenarios based on shale gas utilization in these counties. In order to explore the influence of shale gas production on air quality, we investigate emissions predicted from our shale gas scenarios with the Weather Research and Forecasting model with chemistry (WRF-Chem) model. In order to do this, we first design a model set-up over Europe and evaluate its performance for the meteorological and chemical parameters. Subsequently we add shale gas emissions fluxes based on the scenarios over the area of the grid in which the shale gas activities are predicted to occur. Finally, we model these emissions and analyze the impact on air quality on both a local and regional scale. The aims of this work are to predict the range of adverse effects on air quality, highlight the importance of emissions control strategies in reducing air pollution, to promote further discussion, and to provide policy makers with information for decision making on a potential shale gas development in the two study countries.

  1. The European Society of Regional Anaesthesia and Pain Therapy/American Society of Regional Anesthesia and Pain Medicine Recommendations on Local Anesthetics and Adjuvants Dosage in Pediatric Regional Anesthesia.

    Science.gov (United States)

    Suresh, Santhanam; Ecoffey, Claude; Bosenberg, Adrian; Lonnqvist, Per-Anne; de Oliveira, Gildasio S; de Leon Casasola, Oscar; de Andrés, José; Ivani, Giorgio

    2018-02-01

    Dosage of local anesthetics (LAs) used for regional anesthesia in children is not well determined. In order to evaluate and come to a consensus regarding some of these controversial topics, The European Society of Regional Anaesthesia and Pain Therapy (ESRA) and the American Society of Regional Anesthesia and Pain Medicine (ASRA) developed a Joint Committee Practice Advisory on Local Anesthetics and Adjuvants Dosage in Pediatric Regional Anesthesia. Representatives from both ASRA and ESRA composed the joint committee practice advisory. Evidence-based recommendations were based on a systematic search of the literature. In cases where no literature was available, expert opinion was elicited. Spinal anesthesia with bupivacaine can be performed with a dose of 1 mg/kg for newborn and/or infant and a dose of 0.5 mg/kg in older children (>1 year of age). Tetracaine 0.5% is recommended for spinal anesthesia (dose, 0.07-0.13 mL/kg). Ultrasound-guided upper-extremity peripheral nerve blocks (eg, axillary, infraclavicular, interscalene, supraclavicular) in children can be performed successfully and safely using a recommended LA dose of bupivacaine or ropivacaine of 0.5 to 1.5 mg/kg. Dexmedetomidine can be used as an adjunct to prolong the duration of peripheral nerve blocks in children. High-level evidence is not yet available to guide dosage of LA used in regional blocks in children. The ASRA/ESRA recommendations intend to provide guidance in order to reduce the large variability of LA dosage currently observed in clinical practice.

  2. Impact of isoprene and nitrogen oxides on O3 chemistry at the local and the regional scale : the ESCOMPTE experiment

    Science.gov (United States)

    Cortinovis, J.; Solmon, F.; Personne, E.; Serça, D.; Rosset, R.

    2003-04-01

    Concentrations of nitrogen oxides (NOx = NO+NO2) and volatile organic compounds (VOCs) play a crucial role in the atmospheric chemistry through the production-destruction of tropospheric O3. In rural areas, NOx concentrations are much lower than in urban areas, whereas VOCs emissions can be relatively high. This is due to a relative longer residence time of VOCs, and to the substantial contribution of Biogenic VOCs (BVOCs) representing more than 85% of all the VOCs emitted at the Earth surface (half of it being isoprene). For these reasons, O3 production in rural areas is most of the time NOx-limited. Taking into account biogenic emissions of isoprene in global scale atmospheric chemistry modeling adds from 10 to 40% to the ozone produced when compared to the same simulation without isoprene. This suggests that BVOCs and NOx emissions must be accounted for in models of atmospheric pollution forecasting at local and regional scales. In this study, we present a sensitivity analysis on the impact of the isoprene and nitrogen oxides emissions at the local and the regional scale. This study is done from data collected during the ESCOMPTE campaign which took place in June and July 2001 in the Marseille region (Southwest France) characterized by both strong natural and anthropogenic sources of trace gases. Isoprene emission experimental data from a Quercus Pubescens Mediterranean forest are used to constrain the 1Dz Soil-Vegetation-Atmospheric-Transfer ISBA model. This SVAT is used in the 3D MESO-NH-Chemistry model to simulate scenarios of pollution at the regional scale including the measured biogenic source for isoprene, and GENEMIS anthropogenic sources for other trace gases. To focus on the chemistry aspect of these simulations, the atmospheric dynamics are set to an "ideal" configuration. We have investigated the impact of the relative position and distance between the biogenic and anthropogenic sources on the O3 budget. According to this, and to the intensity of the

  3. High-resolution modeling of thermal thresholds and environmental influences on coral bleaching for local and regional reef management.

    Science.gov (United States)

    Kumagai, Naoki H; Yamano, Hiroya

    2018-01-01

    Coral reefs are one of the world's most threatened ecosystems, with global and local stressors contributing to their decline. Excessive sea-surface temperatures (SSTs) can cause coral bleaching, resulting in coral death and decreases in coral cover. A SST threshold of 1 °C over the climatological maximum is widely used to predict coral bleaching. In this study, we refined thermal indices predicting coral bleaching at high-spatial resolution (1 km) by statistically optimizing thermal thresholds, as well as considering other environmental influences on bleaching such as ultraviolet (UV) radiation, water turbidity, and cooling effects. We used a coral bleaching dataset derived from the web-based monitoring system Sango Map Project, at scales appropriate for the local and regional conservation of Japanese coral reefs. We recorded coral bleaching events in the years 2004-2016 in Japan. We revealed the influence of multiple factors on the ability to predict coral bleaching, including selection of thermal indices, statistical optimization of thermal thresholds, quantification of multiple environmental influences, and use of multiple modeling methods (generalized linear models and random forests). After optimization, differences in predictive ability among thermal indices were negligible. Thermal index, UV radiation, water turbidity, and cooling effects were important predictors of the occurrence of coral bleaching. Predictions based on the best model revealed that coral reefs in Japan have experienced recent and widespread bleaching. A practical method to reduce bleaching frequency by screening UV radiation was also demonstrated in this paper.

  4. Local-scale models reveal ecological niche variability in amphibian and reptile communities from two contrasting biogeographic regions

    Directory of Open Access Journals (Sweden)

    Alberto Muñoz

    2016-10-01

    Full Text Available Ecological Niche Models (ENMs are widely used to describe how environmental factors influence species distribution. Modelling at a local scale, compared to a large scale within a high environmental gradient, can improve our understanding of ecological species niches. The main goal of this study is to assess and compare the contribution of environmental variables to amphibian and reptile ENMs in two Spanish national parks located in contrasting biogeographic regions, i.e., the Mediterranean and the Atlantic area. The ENMs were built with maximum entropy modelling using 11 environmental variables in each territory. The contributions of these variables to the models were analysed and classified using various statistical procedures (Mann–Whitney U tests, Principal Components Analysis and General Linear Models. Distance to the hydrological network was consistently the most relevant variable for both parks and taxonomic classes. Topographic variables (i.e., slope and altitude were the second most predictive variables, followed by climatic variables. Differences in variable contribution were observed between parks and taxonomic classes. Variables related to water availability had the larger contribution to the models in the Mediterranean park, while topography variables were decisive in the Atlantic park. Specific response curves to environmental variables were in accordance with the biogeographic affinity of species (Mediterranean and non-Mediterranean species and taxonomy (amphibians and reptiles. Interestingly, these results were observed for species located in both parks, particularly those situated at their range limits. Our findings show that ecological niche models built at local scale reveal differences in habitat preferences within a wide environmental gradient. Therefore, modelling at local scales rather than assuming large-scale models could be preferable for the establishment of conservation strategies for herptile species in natural

  5. Local-scale models reveal ecological niche variability in amphibian and reptile communities from two contrasting biogeographic regions

    Science.gov (United States)

    Santos, Xavier; Felicísimo, Ángel M.

    2016-01-01

    Ecological Niche Models (ENMs) are widely used to describe how environmental factors influence species distribution. Modelling at a local scale, compared to a large scale within a high environmental gradient, can improve our understanding of ecological species niches. The main goal of this study is to assess and compare the contribution of environmental variables to amphibian and reptile ENMs in two Spanish national parks located in contrasting biogeographic regions, i.e., the Mediterranean and the Atlantic area. The ENMs were built with maximum entropy modelling using 11 environmental variables in each territory. The contributions of these variables to the models were analysed and classified using various statistical procedures (Mann–Whitney U tests, Principal Components Analysis and General Linear Models). Distance to the hydrological network was consistently the most relevant variable for both parks and taxonomic classes. Topographic variables (i.e., slope and altitude) were the second most predictive variables, followed by climatic variables. Differences in variable contribution were observed between parks and taxonomic classes. Variables related to water availability had the larger contribution to the models in the Mediterranean park, while topography variables were decisive in the Atlantic park. Specific response curves to environmental variables were in accordance with the biogeographic affinity of species (Mediterranean and non-Mediterranean species) and taxonomy (amphibians and reptiles). Interestingly, these results were observed for species located in both parks, particularly those situated at their range limits. Our findings show that ecological niche models built at local scale reveal differences in habitat preferences within a wide environmental gradient. Therefore, modelling at local scales rather than assuming large-scale models could be preferable for the establishment of conservation strategies for herptile species in natural parks. PMID

  6. Differentiating local and regional sources of Chinese urban air pollution based on the effect of the Spring Festival

    Science.gov (United States)

    Wang, Chuan; Huang, Xiao-Feng; Zhu, Qiao; Cao, Li-Ming; Zhang, Bin; He, Ling-Yan

    2017-07-01

    The emission of pollutants is extremely reduced during the annual Chinese Spring Festival (SF) in Shenzhen, China. During the SF, traffic flow drops by ˜ 50 % and the industrial plants are almost entirely shut down in Shenzhen. To characterize the variation in ambient air pollutants due to the Spring Festival effect, various gaseous and particulate pollutants were measured in real time in urban Shenzhen over three consecutive winters (2014-2016). The results indicate that the concentrations of NOx, volatile organic compounds (VOCs), black carbon (BC), primary organic aerosols, chloride, and nitrate in submicron aerosols decrease by 50-80 % during SF periods relative to non-Spring Festival periods, regardless of meteorological conditions. This decrease suggests that these pollutants are mostly emitted or secondarily formed from urban local emissions. The concentration variation in species mostly from regional or natural sources, however, is found to be much less, such as for bulk fine particulate matter (PM2. 5). More detailed analysis of the Spring Festival effect reveals an urgent need to reduce emissions of SO2 and VOCs on a regional scale rather than on an urban scale to reduce urban PM2. 5 in Shenzhen, which can also be useful as a reference for other megacities in China.

  7. Spatial Dynamics of the Blue Crab Spawning Stock in the Gulf of Mexico: Local Processes Driving Regional Patterns.

    Science.gov (United States)

    Darnell, M. Z.

    2016-02-01

    Female blue crabs undertake a critical spawning migration seaward, migrating from low-salinity mating habitat to high-salinity waters of the lower estuaries and coastal ocean, where larval survival is highest. This migration occurs primarily through ebb tide transport, driven by an endogenous circatidal rhythm in vertical swimming that is modulated by behavioral responses to environmental cues. Blue crabs are typically considered an estuarine species and fisheries are managed on a state-by-state basis. Yet recent evidence from state and regional fishery independent survey programs suggests that the spawning migration can take females substantial distances offshore (>150 km), and that offshore waters are important spawning grounds for female blue crabs in the Gulf of Mexico. This is especially true in areas where freshwater inflow is high, resulting in low estuarine and coastal salinities. In low-salinity, high-inflow areas (e.g., Louisiana), spawning occurs further offshore while in high-salinity, low-inflow areas (e.g., South Texas), spawning takes place primarily within the estuary. Regional patterns in spawning locations both inshore and offshore are driven by interactions between behavioral mechanisms and local oceanographic conditions during the spawning migration. These environmentally driven differences in spawning locations have implications for larval survival and population connectivity, and emphasize the need for interjurisdictional assessment and management of the blue crab spawning stock.

  8. American policy conflict in the greenhouse: Divergent trends in federal, regional, state, and local green energy and climate change policy

    International Nuclear Information System (INIS)

    Byrne, John; Hughes, Kristen; Rickerson, Wilson; Kurdgelashvili, Lado

    2007-01-01

    Climate change threatens significant impacts on global ecosystems and human populations. To address this challenge, industrialized nations have ratified the Kyoto Protocol and undertaken commitments to reduce emissions of greenhouse gases, the primary agents linked to anthropogenic alteration of earth's climate. By contrast, the US government, led by the Bush Administration, has rejected mandatory targets for curbing emissions under the Protocol, and has instead pursued voluntary mitigation measures amid a larger push for clean coal and 'next generation' nuclear technologies. These actions in total have fueled global perceptions that the US is not acting in substantial ways to address climate change. Nevertheless, action within the US is indeed moving forward, with states, cities and regional partnerships filling the federal leadership vacuum. This paper reviews the diverse policies, strategies, and cooperative frameworks that have emerged at regional, state and local levels to guide climate protection, and identifies the environmental and economic benefits linked to such programs. The paper also attempts to explain the existing federal impasse on climate policy, with attention given to how sub-national efforts may ultimately obviate national governmental inaction

  9. Biomaterial-based regional chemotherapy: Local anticancer drug delivery to enhance chemotherapy and minimize its side-effects.

    Science.gov (United States)

    Krukiewicz, Katarzyna; Zak, Jerzy K

    2016-05-01

    Since the majority of anticancer pharmacological agents affect not only cancer tissue but also normal cells, chemotherapy is usually accompanied with severe side effects. Regional chemotherapy, as the alternative version of conventional treatment, leads to the enhancement of the therapeutic efficiency of anticancer drugs and, simultaneously, reduction of toxic effects to healthy tissues. This paper provides an insight into different approaches of local delivery of chemotherapeutics, such as the injection of anticancer agents directly into tumor tissue, the use of injectable in situ forming drug carriers or injectable platforms in a form of implants. The wide range of biomaterials used as reservoirs of anticancer drugs is described, i.e. poly(ethylene glycol) and its copolymers, polyurethanes, poly(lactic acid) and its copolymers, poly(ɛ-caprolactone), polyanhydrides, chitosan, cellulose, cyclodextrins, silk, conducting polymers, modified titanium surfaces, calcium phosphate based biomaterials, silicone and silica implants, as well as carbon nanotubes and graphene. To emphasize the applicability of regional chemotherapy in cancer treatment, the commercially available products approved by the relevant health agencies are presented. Copyright © 2016 Elsevier B.V. All rights reserved.

  10. Effect of preoperative S-1 combined with regional transcatheter arterial chemoembolization on malignant degree of locally advanced gastric cancer

    Directory of Open Access Journals (Sweden)

    Ru-Juan Xu

    2016-07-01

    Full Text Available Objective: To study the effect of preoperative S-1 combined with regional transcatheter arterial chemoembolization on malignant degree of locally advanced gastric cancer. Methods: A total of 134 patients who were diagnosed with advanced gastric cancer in our hospital from May 2012 to December 2014 were selected for study, received surgical resection after chemotherapy, and were divided into intravenous chemotherapy group and combined treatment group according to different chemotherapy regimens. After chemotherapy and before operation, serum tumor marker levels were detected; after operation, recurrence and metastasis-related molecule levels in tumor tissue were detected. Results: After chemotherapy and before operation, serum CEA, CA199, CA72-4, TSGF, ESM-1 and DKK-1 levels of combined treatment group were significantly lower than those of intravenous chemotherapy group; TET1, TET2, LATS1 and RUNX3 levels in tumor tissue of combined treatment group were higher than those of intravenous chemotherapy group while Sipa1, GOLPH3, AEP, MT2- MMP, OPN, Galectin-1, Galectin-3 and Galectin-9 levels were lower than those of intravenous chemotherapy group. Conclusions: Compared with systemic intravenous chemotherapy, preoperative S-1 combined with regional transcatheter arterial chemoembolization can more effectively kill gastric cancer cells and prevent tumor recurrence and metastasis at molecular level.

  11. Leaching of biocides from building facades: Upscaling of a local two-region leaching model to the city scale

    Science.gov (United States)

    Coutu, S.; Rota, C.; Rossi, L.; Barry, D. A.

    2011-12-01

    Facades are protected by paints that contain biocides as protection against degradation. These biocides are leached by rainfall (albeit at low concentrations). At the city scale, however, the surface area of building facades is significant, and leached biocides are a potential environmental risk to receiving waters. A city-scale biocide-leaching model was developed based on two main steps. In the first step, laboratory experiments on a single facade were used to calibrate and validate a 1D, two-region phenomenological model of biocide leaching. The same data set was analyzed independently by another research group who found empirically that biocide leachate breakthrough curves were well represented by a sum of two exponentials. Interestingly, the two-region model was found analytically to reproduce this functional form as a special case. The second step in the method is site-specific, and involves upscaling the validated single facade model to a particular city. In this step, (i) GIS-based estimates of facade heights and areas are deduced using the city's cadastral data, (ii) facade flow is estimated using local meteorological data (rainfall, wind direction) and (iii) paint application rates are modeled as a stochastic process based on manufacturers' recommendations. The methodology was applied to Lausanne, Switzerland, a city of about 200,000 inhabitants. Approximately 30% of the annually applied mass of biocides was estimated to be released to the environment.

  12. 17 years of grassland management leads to parallel local and regional biodiversity shifts among a wide range of taxonomic groups

    NARCIS (Netherlands)

    van Noordwijk, C. G.E.; Baeten, Lander; Turin, Hans; Heijerman, Theodoor; Alders, Kees; Boer, Peter; Mabelis, A. A.; Aukema, Berend; Noordam, Aart; Remke, Eva; Siepel, Henk; Berg, Matty P.; Bonte, Dries

    2017-01-01

    Conservation management is expected to increase local biodiversity, but uniform management may lead to biotic homogenization and diversity losses at the regional scale. We evaluated the effects of renewed grazing and cutting management carried out across a whole region, on the diversity of plants

  13. Metropolitan governance and infrastructure in São Paulo: the challenge of mediating regional interests and local impact

    Directory of Open Access Journals (Sweden)

    Marcelo Sacenco Asquino

    2010-12-01

    Full Text Available The formation of the São Paulo metropolis is related to the historical process of building regional infrastructure as of the late 19th century, in connection with economic motivation and territorial influences. Since that time, São Paulo has played a key role in the network of cities that has been fundamental to its economic development and to its recognition as the most important city in Brazil. This article examines the importance of understanding the regional scale in relation to São Paulo's plans and projects, from Plano de Avenidas (Avenue Plan in the 1930s to the Rodoanel (ring road in the 1990s; the experience of planning and management of the metropolitan system in the 1970s and, in contrast, the environmental licensing process of these large projects after the 1990s. Discussing São Paulo's plans and projects is a complex task, because a project's local impact as well as regional interests must be considered. From different perspectives, the author reviewed the results of environmental licensing of Ampliação da Calha do Rio Tietê (deepening the bed of the Tietê river and Rodoanel Trecho Sul (south section of the ring road projects, and their actual role in the future arrangement and development of the São Paulo metropolis. Based on (a the results of the metropolitan planning experience in the 1970s, (b the updating of the metropolitan discussion in the 1990s from an economic globalization perspective, and (c the current experience of metropolitan systems in the state of São Paulo, it seems necessary to re-establish an effective metropolitan planning and management system in order to guarantee its legitimacy, commitment and governance.

  14. Localization of a Region in the Fusion Protein of Avian Metapneumovirus That Modulates Cell-Cell Fusion

    Science.gov (United States)

    Wei, Yongwei; Feng, Kurtis; Yao, Xiangjie; Cai, Hui; Li, Junan; Mirza, Anne M.; Iorio, Ronald M.

    2012-01-01

    The genus Metapneumovirus within the subfamily Pneumovirinae of the family Paramyxoviridae includes two members, human metapneumovirus (hMPV) and avian metapneumovirus (aMPV), causing respiratory tract infections in humans and birds, respectively. Paramyxoviruses enter host cells by fusing the viral envelope with a host cell membrane. Membrane fusion of hMPV appears to be unique, in that fusion of some hMPV strains requires low pH. Here, we show that the fusion (F) proteins of aMPV promote fusion in the absence of the attachment protein and low pH is not required. Furthermore, there are notable differences in cell-cell fusion among aMPV subtypes. Trypsin was required for cell-cell fusion induced by subtype B but not subtypes A and C. The F protein of aMPV subtype A was highly fusogenic, whereas those from subtypes B and C were not. By construction and evaluation of chimeric F proteins composed of domains from the F proteins of subtypes A and B, we localized a region composed of amino acid residues 170 to 338 in the F protein that is responsible for the hyperfusogenic phenotype of the F from subtype A. Further mutagenesis analysis revealed that residues R295, G297, and K323 in this region collectively contributed to the hyperfusogenicity. Taken together, we have identified a region in the aMPV F protein that modulates the extent of membrane fusion. A model for fusion consistent with these data is presented. PMID:22915815

  15. THE LOCAL PRODUCTIVE ARRANGEMENTS IN THE OURINHOS GOVERNMENT REGION - SÃO PAULO - BRAZIL: SOCIO-PRODUCTIVE DYNAMIC AND TERRITORIAL DEVELOPMENT

    Directory of Open Access Journals (Sweden)

    Lucas Labigalini Fuini

    2014-03-01

    Full Text Available This article seeks to develop an analysis of the territorial evidences of discussion on local productive arrangements, those clusters, using as spatial scale of the regional analysis, more precisely the Ourinhos Government Region. Form of industrial organization emerging in the 1990s, the APLs express localized concentrations of specialized companies in the same industry and establishing partnerships among themselves and with other institutions, with varying impacts on the development and governance of cities. Far from exhausting this debate, we consider the model of APL as an alternative strategy for the development of territories and their small businesses, despite their financial and institutional weaknesses. Also, put hypothesized that there are potential clusters and agglomerations in the Ourinhos region that are still unknown and did not receive institutional and financial contribution of the state, staying on the sidelines of the economic benefits of local development, for which they are poorly organized or disorganized. Tracing the framework of national and local policies to arrangements and productive agglomerations, accentuates the way of development in clusters like that guided resources, institutions and local networks, dependent, however, the larger scales of government action. That said, we propose a methodology of analysis grounded in documentary and statistical data research (IBGE and RAIS seeking to achieve the objectives of identifying the major industrial clusters in the region studied, recognizing its dynamism to local economies and relevance or not to consider some regional industrial agglomerations as APLs.

  16. Spatial Collaboration Model among Local Governments in Ratubangnegoro Region in the Boundary Area of Central Java and East Java Provinces, Indonesia

    Science.gov (United States)

    Wahyono, H.; Wahdah, L.

    2018-02-01

    In Indonesia, according to Law No. 23/2014 on Local Government, a local government can conduct cooperation with other local governments that are based on considerations of efficiency and effectiveness of public services and mutual benefit, in order to improve people's welfare. Such cooperation can be categorized into mandatory and voluntary cooperation. Cooperation shall be developed jointly between the adjacent areas for the implementation of government affairs which have cross-local government externalities; and the provision of public services more efficient if managed together. One of the parts of the area that is directly related to the implementation of the policy liabilities of inter-local government cooperation which is mandated is the he province boundary areas. The public management of the provincial boundary areas is different from the central province area. While the central province area considers only their own interests, the management of boundary development must consider the neighboring regions. On one hand, the area is influenced only by its own province policy, while on the other influenced by neighboring regions. Meanwhile, a local government tends to resist the influence and intervention of neighboring regions. Likewise, neighboring local governments also tend to resist the influence and intervention of other local governments. Therefore, when interacting on the boundary, inter-local government interaction is not only the potential for cooperation, but also conflict-prone regions. One of the boundary area provinces attempt to implement the collaborative planning approach is the boundary area of Central Java Province and East Java Province, which is known as Ratubangnegoro Region. Ratubangnegoro region is one of the strategic areas of both provinces. In order to the interaction between the region could take place, there are regencies in the region have formed and joined the Inter-Local Government Cooperation Agency (BKAD-Badan Kerjasama Antar

  17. An integrated system for the determination of the local, regional and long-transport contributions to Particulate Matter concentrations

    Science.gov (United States)

    Amodio, M.; Andriani, E.; Daresta, B. E.; de Gennaro, G.; di Gilio, A.; Ielpo, P.,; Placentino, C. M.; Trizio, L.; Tutino, M.

    2010-05-01

    Several epidemiological studies have shown the negative effects of air pollution on human health, which range from respiratory and cardiovascular disease to neurotoxic effects, and cancer. Most recent investigations have been focused on health toxicological features of Particulate Matter (PM) and its interactions with other pollutants: it was found that fine particles (PM2.5) could be an effective media to transport these pollutants deeply into the lung and to cause many kind of reactions which include oxidative stress, local pulmonary and systemic inflammatory responses (Künzli and Perez, 2009). Based on these implications on public health, many countries have developed plans to suggest effective control strategies which involve the identification of Particulate Matter sources, the quantitative estimation of the emission rates of the pollutants, the understanding of PM transport, mixing and transformation processes and the identification of main factors influencing PM concentrations. In this field, receptor models can be useful tools to estimate sources contributions to PM collected in an area under investigations. Different approaches to receptor model analysis can be distinguished on basis of whether chemical characteristics of emission sources are required to be known before the source apportionment. The multivariate approach could be preferred when a lack of information concerning sources profiles occurred (Hopke, 2003). In this work, the results obtained by applying an integrated approach in the monitoring of PM using several typologies of instrumentations will be shown. A prototype for the determination of the contributions of a single source (‘fugitive emission') on the fine PM concentrations has been developed: it consists of a Swam dual-channel sampler, an OPC Monitor, a sonic anemometer and a PBL Mixing monitor. The investigated site chosen for the application of prototype will be the iron and steel pole of Taranto (Apulia Region, South of Italy

  18. Regional expression and ultrastructural localization of EphA7 in the hippocampus and cerebellum of adult rat.

    Science.gov (United States)

    Amegandjin, Clara A; Jammow, Wafaa; Laforest, Sylvie; Riad, Mustapha; Baharnoori, Moogeh; Badeaux, Frédérique; DesGroseillers, Luc; Murai, Keith K; Pasquale, Elena B; Drolet, Guy; Doucet, Guy

    2016-08-15

    EphA7 is expressed in the adult central nervous system (CNS), where its roles are yet poorly defined. We mapped its distribution using in situ hybridization (ISH) and immunohistochemistry (IHC) combined with light (LM) and electron microscopy (EM) in adult rat and mouse brain. The strongest ISH signal was in the hippocampal pyramidal and granule cell layers. Moderate levels were detected in habenula, striatum, amygdala, the cingulate, piriform and entorhinal cortex, and in cerebellum, notably the Purkinje cell layer. The IHC signal distribution was consistent with ISH results, with transport of the protein to processes, as exemplified in the hippocampal neuropil layers and weakly stained pyramidal cell layers. In contrast, in the cerebellum, the Purkinje cell bodies were the most strongly immunolabeled elements. EM localized the cell surface-expression of EphA7 essentially in postsynaptic densities (PSDs) of dendritic spines and shafts, and on some astrocytic leaflets, in both hippocampus and cerebellum. Perikaryal and dendritic labeling was mostly intracellular, associated with the synthetic and trafficking machineries. Immunopositive vesicles were also observed in axons and axon terminals. Quantitative analysis in EM showed significant differences in the frequency of labeled elements between regions. Notably, labeled dendrites were ∼3-5 times less frequent in cerebellum than in hippocampus, but they were individually endowed with ∼10-40 times higher frequencies of PSDs, on their shafts and spines. The cell surface localization of EphA7, being preferentially in PSDs, and in perisynaptic astrocytic leaflets, provides morphologic evidence that EphA7 plays key roles in adult CNS synaptic maintenance, plasticity, or function. J. Comp. Neurol. 524:2462-2478, 2016. © 2016 Wiley Periodicals, Inc. © 2016 Wiley Periodicals, Inc.

  19. Local and regional scale exchanges of dissolved organic carbon (DOC) between tidal wetlands and their adjacent coastal waters

    Science.gov (United States)

    Osburn, C. L.; Joshi, I.; Lebrasse, M. C.; Oviedo-Vargas, D.; Bianchi, T. S.; Bohnenstiehl, D. R.; D'Sa, E. J.; He, R.; Ko, D.; Arellano, A.; Ward, N. D.

    2017-12-01

    The contribution of blue carbon from tidal wetlands to the coastal ocean in the form of dissolved organic carbon (DOC) represents a terrestrial-aquatic linkage of increasing importance. DOC flux results will be presented from local (tidal creek) and regional (bays) scale studies in which various combinations of field observations, ocean-color satellite observations, and the outputs of high-resolution hydrodynamic models were used to estimate DOC export. The first project was located in Bald Head Creek, a tributary to the Cape Fear River estuary in eastern North Carolina (NC). DOC fluxes were computed using a bathymetric data collected via unmanned surface vehicle (USV) and a numerical hydrodynamic model (SCHISM) based on the relationships between colored dissolved organic matter (CDOM) absorption, DOC concentration, and salinity taken from field observations. Model predictions estimated an annual net export of DOC at 54 g C m-2 yr-1 from the tidal creek to the adjacent estuary. Carbon stable isotope (δ13C) values were used to estimate the contribution of wetland carbon to this export. In the second project, DOC fluxes from the Apalachicola Bay, FL, Barataria Bay, LA, were based on the development of algorithms between DOC and CDOM absorption derived from the VIIRS ocean color sensor. The Navy Coastal Ocean Model (NCOM) was used to compute salt flux estimates from each bay to the Louisiana-Texas shelf. The relationship between salinity and CDOM was used to estimate net annual DOC exports of 8.35 x 106 g C m-2 y-1 (Apalachicola Bay) and 7.14 x 106 g C m-2 yr-1 (Barataria Bay). These values approximate 13% and 9% of the annual loads of DOC from the Mississippi River to the Gulf of Mexico, respectively. CDOM and lignin were used in a mixing model to estimate wetland-derived DOC were 2% for Apalachicola Bay and 13% for Barataria Bay, the latter having one of the highest rates of relative sea level rise in North America. Results from our project demonstrated the utility

  20. Fish assemblages in coastal lagoons in land-uplift succession: The relative importance of local and regional environmental gradients

    Science.gov (United States)

    Snickars, Martin; Sandström, Alfred; Lappalainen, Antti; Mattila, Johanna; Rosqvist, Kajsa; Urho, Lauri

    2009-01-01

    The assemblages of young-of-the-year fish were studied in coastal lagoons in an archipelago with post-glacial land-uplift, which affects environmental gradients at local and regional scale, i.e. lagoon habitat isolation and archipelago position, respectively. The categorisation of 40 undisturbed lagoons into nine habitat types based on habitat isolation and archipelago position was supported by clear relationships with spring temperature and total fish abundance. Rutilus rutilus, breams ( Abramis/Blicca sp.) and Perca fluviatilis were the most abundant and frequently occurring species. The fish assemblage differed among the nine habitat types. Rutilus rutilus, P. fluviatilis and breams were discriminating species in the majority of habitat types with low physical harshness, whereas Alburnus alburnus and Gasterosteus aculeatus increased their contributions in habitat types with high physical harshness. Rutilus rutilus and breams were thus common in lagoons with high habitat isolation situated in the inner archipelago. These lagoons were characterised by warm water and high vegetation coverage. Gasterosteus aculeatus was restricted to lagoons with low habitat isolation and exposure and low vegetation coverage, situated in the outer archipelago. Perca fluviatilis had the widest distribution of all species. The coverage of two macrophytes, Potamogeton perfoliatus and Zannichellia palustris, and salinity matched best the distance among habitat types. These habitat characteristics, as well as the fish abundances and assemblages differed most across the habitat types in the outer and mid archipelago zones and in the lowest habitat isolation. These patterns suggest that the structuring effect of habitat isolation increases along the archipelago gradient as differences between local and regional conditions increase. In the inner archipelago, overall low physical harshness induces homogeneous conditions and the habitat isolation is less important here than in the other zones

  1. Intravenous regional anesthesia: a review of common local anesthetic options and the use of opioids and muscle relaxants as adjuncts

    Directory of Open Access Journals (Sweden)

    Flamer D

    2011-11-01

    Full Text Available David Flamer, Philip WH PengDepartment of Anesthesia, Toronto Western Hospital, University Health Network, University of Toronto, Toronto, ON, CanadaPurpose: To provide a review of local anesthetic (LA agents and adjuncts, opioids and muscle relaxants, and their intraoperative effects and postoperative outcomes in intravenous regional anesthesia (IVRA.Source: A search for prospective, double-blind, randomized controlled trials evaluating LA agents, opioids and muscle relaxants as adjuvants for IVRA, was conducted (MEDLINE®, Embase. Intraoperative benefits (onset/recovery of sensory and motor block, intraoperative analgesia, tourniquet pain, postoperative benefits (pain score, analgesic consumption, time to first analgesia, and side effects were recorded. A conclusion for overall benefit was made based on statistical significance and clinical relevance.Findings: Thirty-one studies were evaluated, with data collected on 1523 subjects. LA agents evaluated were lidocaine, ropivacaine, and prilocaine. Adjuncts evaluated were opioids (morphine, fentanyl, meperidine, sufentanil, tramadol and muscle relaxants (pancuronium, atracurium, mivacurium, cisatacurium. There was good evidence that ropivacaine provided effective IVRA and improved postoperative analgesia. Lidocaine and prilocaine were effective LA agents, however they lacked postoperative benefits. Morphine, fentanyl, and meperidine as sole adjuncts did not demonstrate clinically significant benefits or result in an increased risk of side effects. Sufentanil data was limited, but appeared to provide faster onset of sensory block. Tramadol provided faster onset of sensory block and tourniquet tolerance, however postoperative benefits were not consistent and the risk of minor side effects increased. Muscle relaxants improved the quality of motor block, but at the expense of delayed motor recovery. The combination of fentanyl and muscle relaxants can achieve an equivalent quality of IVRA with 50

  2. The genomic landscape at a late stage of stickleback speciation: High genomic divergence interspersed by small localized regions of introgression.

    Directory of Open Access Journals (Sweden)

    Mark Ravinet

    2018-05-01

    Full Text Available Speciation is a continuous process and analysis of species pairs at different stages of divergence provides insight into how it unfolds. Previous genomic studies on young species pairs have revealed peaks of divergence and heterogeneous genomic differentiation. Yet less known is how localised peaks of differentiation progress to genome-wide divergence during the later stages of speciation in the presence of persistent gene flow. Spanning the speciation continuum, stickleback species pairs are ideal for investigating how genomic divergence builds up during speciation. However, attention has largely focused on young postglacial species pairs, with little knowledge of the genomic signatures of divergence and introgression in older stickleback systems. The Japanese stickleback species pair, composed of the Pacific Ocean three-spined stickleback (Gasterosteus aculeatus and the Japan Sea stickleback (G. nipponicus, which co-occur in the Japanese islands, is at a late stage of speciation. Divergence likely started well before the end of the last glacial period and crosses between Japan Sea females and Pacific Ocean males result in hybrid male sterility. Here we use coalescent analyses and Approximate Bayesian Computation to show that the two species split approximately 0.68-1 million years ago but that they have continued to exchange genes at a low rate throughout divergence. Population genomic data revealed that, despite gene flow, a high level of genomic differentiation is maintained across the majority of the genome. However, we identified multiple, small regions of introgression, occurring mainly in areas of low recombination rate. Our results demonstrate that a high level of genome-wide divergence can establish in the face of persistent introgression and that gene flow can be localized to small genomic regions at the later stages of speciation with gene flow.

  3. Modulation of local field potentials by high-frequency stimulation of afferent axons in the hippocampal CA1 region.

    Science.gov (United States)

    Yu, Ying; Feng, Zhouyan; Cao, Jiayue; Guo, Zheshan; Wang, Zhaoxiang; Hu, Na; Wei, Xuefeng

    2016-03-01

    Modulation of the rhythmic activity of local field potentials (LFP) in neuronal networks could be a mechanism of deep brain stimulation (DBS). However, exact changes of LFP during the periods of high-frequency stimulation (HFS) of DBS are unclear because of the interference of dense stimulation artifacts with high amplitudes. In the present study, we investigated LFP changes induced by HFS of afferent axons in the hippocampal CA1 region of urethane-anesthetized rats by using a proper algorithm of artifact removal. Afterward, the LFP changes in the frequency bands of [Formula: see text], [Formula: see text], [Formula: see text], [Formula: see text] and [Formula: see text] rhythms were studied by power spectrum analysis and coherence analysis for the recorded signals collected in the pyramidal layer and in the stratum radiatum of CA1 region before, during and after 1-min long 100 and 200[Formula: see text]Hz HFS. Results showed that the power of LFP rhythms in higher-frequency band ([Formula: see text] rhythm) increased in the pyramidal layer and the power of LFP rhythms in lower-frequency bands ([Formula: see text], [Formula: see text] and [Formula: see text] rhythms) decreased in the stratum radiatum during HFS. The synchronization of [Formula: see text] rhythm decreased and the synchronization of [Formula: see text] rhythm increased during HFS in the stratum radiatum. These results suggest that axonal HFS could modulate LFP rhythms in the downstream brain areas with a plausible underlying mechanism of partial axonal blockage induced by HFS. The study provides new evidence to support the mechanism of DBS modulating rhythmic activity of neuronal populations.

  4. The genomic landscape at a late stage of stickleback speciation: High genomic divergence interspersed by small localized regions of introgression.

    Science.gov (United States)

    Ravinet, Mark; Yoshida, Kohta; Shigenobu, Shuji; Toyoda, Atsushi; Fujiyama, Asao; Kitano, Jun

    2018-05-01

    Speciation is a continuous process and analysis of species pairs at different stages of divergence provides insight into how it unfolds. Previous genomic studies on young species pairs have revealed peaks of divergence and heterogeneous genomic differentiation. Yet less known is how localised peaks of differentiation progress to genome-wide divergence during the later stages of speciation in the presence of persistent gene flow. Spanning the speciation continuum, stickleback species pairs are ideal for investigating how genomic divergence builds up during speciation. However, attention has largely focused on young postglacial species pairs, with little knowledge of the genomic signatures of divergence and introgression in older stickleback systems. The Japanese stickleback species pair, composed of the Pacific Ocean three-spined stickleback (Gasterosteus aculeatus) and the Japan Sea stickleback (G. nipponicus), which co-occur in the Japanese islands, is at a late stage of speciation. Divergence likely started well before the end of the last glacial period and crosses between Japan Sea females and Pacific Ocean males result in hybrid male sterility. Here we use coalescent analyses and Approximate Bayesian Computation to show that the two species split approximately 0.68-1 million years ago but that they have continued to exchange genes at a low rate throughout divergence. Population genomic data revealed that, despite gene flow, a high level of genomic differentiation is maintained across the majority of the genome. However, we identified multiple, small regions of introgression, occurring mainly in areas of low recombination rate. Our results demonstrate that a high level of genome-wide divergence can establish in the face of persistent introgression and that gene flow can be localized to small genomic regions at the later stages of speciation with gene flow.

  5. Enhancing Decision Support For Climate Adaptation At Sub-Regional To Local Scales Through Collaborative And Interdisciplinary Global Change Research And Application

    Science.gov (United States)

    Arnott, J. C.; Katzenberger, J.

    2012-12-01

    The science needed to inform society's response to global environmental change is increasingly demanded at sub-regional to local scales, placing a greater burden on the science community to respond to a wide variety of information needs. Oftentimes, communication barriers prevent even the basic articulation of information needs between the user and science research communities, and furthermore there is frequently a mismatch between available scientific talent within a sub region and the scientific resources demanded to respond appropriately to user inquiries. As a result, innovative approaches to the delivery of scientific information in response to user interests and needs at sub-regional to local levels is required. Here, the authors highlight lessons of three examples of delivering usable scientific information within a mountain watershed on questions relating to 1) local biomass energy production; 2) stream and forest health; and 3) watershed scale climate impacts assessment. We report that common elements to the success of these efforts include a) building relationships with both a broad range of disciplines within the science community as well as a wide range of stakeholder groups locally, b) collecting and translating existing monitoring data and filling monitoring gaps, c) gathering interdisciplinary teams to help answer difficult local scale questions not previously treated in literature, and d) communicating results through mechanisms such as stakeholder collaboratives, community forums, and innovative education and outreach products. We find that these components help communities at local to sub-regional scales identify vulnerabilities and adapative strategies.

  6. Effects of local geology on ground motion in the San Francisco Bay region, California—A continued study

    Science.gov (United States)

    Gibbs, James F.; Borcherdt, Roger D.

    1974-01-01

    Measurements of ground motion generated by nuclear explosions in Nevada have been completed for 99 locations in the San Francisco Bay region, California. The seismograms, Fourier amplitude spectra, spectral amplification curves for the signal, and the Fourier amplitude spectra of the seismic noise are presented for 60 locations. Analog amplifications, based on the maximum signal amplitude, are computed for an additional 39 locations. The recordings of the nuclear explosions show marked amplitude variations which are consistently related to the local geologic conditions of the recording site. The average spectral amplifications observed for vertical and horizontal ground motions are, respectively: (1, 1) for granite, (1.5, 1.6) for the Franciscan Formation, (2.3, 2.3), for other pre-Tertiary and Tertiary rocks, (3.0, 2.7) for the Santa Clara Formation, (3.3, 4.4) for older bay sediments, and (3.7, 11.3) for younger bay mud. Spectral amplification curves define predominant ground frequencies for younger bay mud sites and for some older bay sediment sites. The predominant frequencies for most sites were not clearly defined by the amplitude spectra computed from the seismic background noise. The intensities ascribed to various sites in the San Francisco Bay region for the California earthquake of April 18, 1906, are strongly dependent on distance from the zone of surface faulting and the geological character of the ground. Considering only those sites (approximately one square city block in size) for which there is good evidence for the degree of ascribed intensity, the intensities for 917 sites on Franciscan rocks generally decrease with the logarithm of distance as Intensity = 2.69 - 1.90 log (Distance Km). For sites on other geologic units, intensity increments, derived from this empirical rela.tion, correlate strongly with the Average Horizontal Spectral Amplifications (MISA) according to the empirical relation Intensity Increment= 0.27 + 2.70 log(AHSA). Average

  7. Quantifying the National Significance of Local Areas for Regional Conservation Planning: North Carolina’s Mountain Treasures

    Directory of Open Access Journals (Sweden)

    R. Travis Belote

    2017-05-01

    Full Text Available Conservation scientists recognize that additional protected areas are needed to maintain biological diversity and ecological processes. As regional conservation planners embark on recommending additional areas for protection in formal ecological reserves, it is important to evaluate candidate lands for their role in building a resilient protected areas system of the future. Here, we evaluate North Carolina’s Mountain Treasures with respect to their (1 ecological integrity, (2 role in connecting existing core protected areas, (3 potential to diversify the ecosystem representation of reserves, and (4 role in maintaining hotspots of biologically-rich areas that are not well protected. Mountain Treasures represent a citizen inventory of roadless areas and serve as candidates for elevated levels of conservation protection on U.S. federal lands. We compared Mountain Treasures to other candidate lands throughout the country to evaluate their potential national significance. While the Mountain Treasures tended to be more impacted by human modifications than other roadless areas, they are as important as other roadless areas with respect to their role in connecting existing protected areas and diversifying representation of ecosystems in conservation reserves. However, Mountain Treasures tended to have a much higher biodiversity priority index than other roadless areas leading to an overall higher composite score compared to other roadless areas. Our analysis serves as an example of how using broad-scale datasets can help conservation planners assess the national significance of local areas.

  8. [A survey of Local Physicians and Psychotherapists on Cooperation in Regional Networks for Early Child Interventions in Saxony-Anhalt].

    Science.gov (United States)

    Clauß, D; Fleischer, S; Mattern, E; Ayerle, G

    2016-07-01

    Early childhood interventions positively contribute to health related child development. For these interventions, networks are a necessary prerequisite as they promote interdisciplinary and interprofessional cooperation. This holds especially true for the integration of health system protagonists. In a cross-sectional survey local paediatrists, gynaecologists, general practitioners, and psychotherapists were asked about their knowledge, experiences, desires, and reservations regarding cooperation in early childhood intervention networks. 64 out of 1747 (3.7%) eligible clinicians answered the survey. On average they estimated that 10.1% of the families they are treating would benefit from early childhood interventions. Participants rated themselves as competent to offer appropriate early childhood interventions. The youth welfare service was judged as the most important institution for their own professional practice by 84.4%. Additionally to an applicable agenda, a fair group moderation of network meetings was seen as a substantial requirement in order to take part in network meetings. Health professionals are important protagonists in early childhood interventions. Clinicians should assess relevant problems in families and offer appropriate support on a regular basis. Alongside clearly defined regional contacts, interprofessional continuing education seems mandatory. © Georg Thieme Verlag KG Stuttgart · New York.

  9. Building a strategy for soil protection at local and regional scale--the case of agricultural wastes landspreading.

    Science.gov (United States)

    Doula, M K; Sarris, A; Hliaoutakis, A; Kydonakis, A; Papadopoulos, N S; Argyriou, L

    2016-03-01

    Agricultural wastes (AW) are produced in huge quantities worldwide and may cause detrimental effects on environmental quality, affecting soil, water, and air quality. Given the growing soil degradation worldwide, the need for more food of good quality and therefore the intensified agriculture, it is important to develop recycling plans even for those types of treated AW (e.g., composts) that are not considered hazardous. Two strategic approaches for safe and sustainable landspreading of organic wastes are proposed, depending on wastes properties and hazard potential, i.e., an approach appropriate for traditionally used wastes (manures and composts) and another approach for wastes that are potentially hazardous or hazardous and should only be reused under specific restrictions. Both approaches foresee concrete steps, require close cooperation between farmers and local/regional authorities, and are appropriate to ensure environmental sustainability at AW recycling or disposal areas. Desktop and web application tools are also presented that are anticipated to assist authorities in implementing their monitoring strategies.

  10. National Agendas and Local Realities: Festive Material and Ritual Culture, Nationalism, and Modernity in the Chita Region of Japan

    Directory of Open Access Journals (Sweden)

    Sean McPherson

    2012-06-01

    Full Text Available The reworking of religious space in modern Japan encompassed the reinvention of the spatial, material, and ritual culture of matsuri 祭り(festivals. After a period of relative official disfavor, festivals in the late nineteenth and early twentieth centuries were reinvigorated by changes in ritual process and spatial scope, as well as by shifts in the architecture and sculpture of dashi 山車 (wheeled festival floats. The incorporation of matsuri into broader discourses of national cultural identity was driven by the affective potential of their supposed cultural authenticity. This reinvention of festivity is evident in the Tokoname Matsuri of Tokoname City, Aichi Prefecture, where after the 1905 Russo-Japanese conflict several Edo-period shrine festivals were merged into a shōkonsai 招魂祭 (festival for the war dead. The spatial scope and ritual process, as well as the architecture and sculptural iconography, of the six dashi built for the new Tokoname Matsuri tied this regional city into national discourses of cultural authenticity, racial purity, and martial valor. The ideological resonance in prewar Japan of the Tokoname Matsuri and other festivals with nationalist imagery sprang from their indelibly local origins; matsuri were not controlled entirely from the top down, but rather were mediated at multiple levels.

  11. Apron heights around stepped massifs in the Cydonia Mensae region: Do they record the local paleobathymetry of Oceanus Borealis?

    Science.gov (United States)

    Parker, T. J.; Gorsline, D. S.

    1993-01-01

    The use of photoclinometry and shadow measurements to determine the basin volume without linking the measurements to a global datum is described. Since the boundary, or shoreline, of the basin cannot be tied to the datum and typically has no useful local relative height to measure, what is needed is a number of measurements of the height of the paleoshorelines distributed across the basin. Photoclinometric profiles are being compiled from Viking Orbiter images of the Cydonia Mensae region, which includes images with high sun elevations, necessary to avoid shadows, and images with low sun elevations, to enable the use of shadow measurements as an independent check, at high resolution (40 to 100 m/pixel). Both asymmetric and symmetric photoclinometric profile models are being used, and the results cross checked with one another to minimize errors. An apron-height map, potentially a paleobathymetric map of part of the margin of Oceanus Borealis, can be compiled from this data to determine whether variations in apron height are consistent with a lacustrine interpretation.

  12. Effect of Radiotherapy Interruptions on Survival in Medicare Enrollees With Local and Regional Head-and-Neck Cancer

    International Nuclear Information System (INIS)

    Fesinmeyer, Megan Dann; Mehta, Vivek; Blough, David; Tock, Lauri; Ramsey, Scott D.

    2010-01-01

    Purpose: To investigate whether interruptions in radiotherapy are associated with decreased survival in a population-based sample of head-and-neck cancer patients. Methods and Materials: Using the Surveillance, Epidemiology, and End Results-Medicare linked database we identified Medicare beneficiaries aged 66 years and older diagnosed with local-regional head-and-neck cancer during the period 1997-2003. We examined claims records of 3864 patients completing radiotherapy for the presence of one or more 5-30-day interruption(s) in therapy. We then performed Cox regression analyses to estimate the association between therapy interruptions and survival. Results: Patients with laryngeal tumors who experienced an interruption in radiotherapy had a 68% (95% confidence interval, 41-200%) increased risk of death, compared with patients with no interruptions. Patients with nasal cavity, nasopharynx, oral, salivary gland, and sinus tumors had similar associations between interruptions and increased risk of death, but these did not reach statistical significance because of small sample sizes. Conclusions: Treatment interruptions seem to influence survival time among patients with laryngeal tumors completing a full course of radiotherapy. At all head-and-neck sites, the association between interruptions and survival is sensitive to confounding by stage and other treatments. Further research is needed to develop methods to identify patients most susceptible to interruption-induced mortality.

  13. Estimation of mercury emissions from forest fires, lakes, regional and local sources using measurements in Milwaukee and an inverse method

    Directory of Open Access Journals (Sweden)

    B. de Foy

    2012-10-01

    Full Text Available Gaseous elemental mercury is a global pollutant that can lead to serious health concerns via deposition to the biosphere and bio-accumulation in the food chain. Hourly measurements between June 2004 and May 2005 in an urban site (Milwaukee, WI show elevated levels of mercury in the atmosphere with numerous short-lived peaks as well as longer-lived episodes. The measurements are analyzed with an inverse model to obtain information about mercury emissions. The model is based on high resolution meteorological simulations (WRF, hourly back-trajectories (WRF-FLEXPART and a chemical transport model (CAMx. The hybrid formulation combining back-trajectories and Eulerian simulations is used to identify potential source regions as well as the impacts of forest fires and lake surface emissions. Uncertainty bounds are estimated using a bootstrap method on the inversions. Comparison with the US Environmental Protection Agency's National Emission Inventory (NEI and Toxic Release Inventory (TRI shows that emissions from coal-fired power plants are properly characterized, but emissions from local urban sources, waste incineration and metal processing could be significantly under-estimated. Emissions from the lake surface and from forest fires were found to have significant impacts on mercury levels in Milwaukee, and to be underestimated by a factor of two or more.

  14. Predicting soil, water and air concentrations of environmental contaminants locally and regionally; multimedia transport and transformation models

    International Nuclear Information System (INIS)

    McKone, T.E.; Daniels, J.I.

    1991-01-01

    Environmental scientists recognize that the environment functions as a complex, interconnected system. A realistic risk-management strategy for many contaminants requires a comprehensive and integrated assessment of local and regional transport and transformation processes. In response to this need, we have developed multimedia models that simulate the movement and transformation of chemicals as they spread through air, water, biota, soils, sediments, surface water and ground water. Each component of the environment is treated as a homogeneous subsystem that can exchange water, nutrients, and chemical contaminants with other adjacent compartments. In this paper, we illustrate the use of multimedia models and measurements as tools for screening the potential risks of contaminants released to air and deposited onto soil and plants. The contaminant list includes the volatile organic compounds (VOCs) tetrachloroethylene (PCE) and trichloroethylene (TCE), the semi-volatile organic compound benzo(a)pyrene, and the radionuclides tritium and uranium-238. We examine how chemical properties effect both the ultimate route and quantity of human and ecosystem contact and identify sensitivities and uncertainties in the model results. We consider the advantages of multimedia models relative to environmental monitoring data. (au)

  15. Predicting soil, water, and air concentrations of environmental contaminants locally and regionally: Multimedia transport and transformation models

    International Nuclear Information System (INIS)

    McKone, T.E.; Daniels, J.I.

    1991-10-01

    Environmental scientists recognize that the environment functions as a complex, interconnected system. A realistic risk-management strategy for many contaminants requires a comprehensive and integrated assessment of local and regional transport and transformation processes. In response to this need, we have developed multimedia models that simulate the movement and transformation of chemicals as they spread through air, water, biota, soils, sediments, surface water, and ground water. Each component of the environment is treated as a homogeneous subsystem that can exchange water, nutrients, and chemical contaminants with other adjacent compartments. In this paper, we illustrate the use of multimedia models and measurements as tools for screening the potential risks of contaminants released to air and deposited onto soil and plants. The contaminant list includes the volatile organic compounds (VOCs) tetrachloroethylene (PCE) and trichloroethylene (TCE), the semi-volatile organic compound benzo(a)pyrene, and the radionuclides tritium and uranium-238. We examine how chemical properties effect both the ultimate route and quantity of human and ecosystem contact and identify sensitivities and uncertainties in the model results

  16. Decentralized electricity generation from renewable sources as a chance for local economic development. A qualitative study of two pioneer regions in Germany

    Energy Technology Data Exchange (ETDEWEB)

    Klagge, Britta; Brocke, Tobias [Osnabrueck Univ. (Germany). Inst. of Geography

    2012-12-15

    Empirical research on the local economic effects associated with decentralized electricity generation from renewable sources has only just started. So far, most studies focus on quantifying economic effects and neglect the conditions and constellations which support and enable local economic development based on decentralized electricity generation. This, however, is the focus of this paper which looks at these issues, employing the value chain concept in combination with a governance perspective. Empirically, we take a qualitative approach and analyze two case studies of pioneer regions, in which decentralized electricity generation from renewable sources has developed very dynamically. The case study regions are Soltau, with a special focus on biogas production, and Emden, where wind energy plays a special role. Based on the early activities of some pioneers, these regions have developed specific actor constellations and organizational structures and have entered development paths in which renewable energies became an important economic factor. The analysis highlights the importance of institutional context and supportive governance structures for an early advancement of decentralized electricity generation from renewable sources, with a key role of local actors and governance constellations. It also points to the importance of cooperative relationships among local business actors for creating a competitive advantage for (some) regional firms. Our analysis shows that with the geographical proliferation of electricity generation from renewable sources, specialized firms tend to reach beyond their regions, thus offering first-mover advantages for firms in pioneer regions in comparison with latecomers.

  17. Practical Problems of Giving Opinions by Regional Chambers of Accounting on the Possibility of Repayment of Obligations in Local Government Units

    Directory of Open Access Journals (Sweden)

    Marcin Tyniewicki

    2014-06-01

    Full Text Available Opinions of the regional accounting chambers on the possibility of repayment of the credit, loan or redemption of the securities by local government units have some specific features compared with the other opinions concerning the financial management of the local government. Firstly, they are only issued at the request of the unit that they concerned. Secondly, for the reason they relate to public debt issues, to some extent their content may be similar or “partial reproduction” of the standpoint of the regional chamber of accounting within already issued opinions referring to acts on budgetary planning process in local government units. The purpose of this article is to assess the legitimacy of issuing such opinions and to identify the relationship between the ordinances (resolutions on the possibility of repayment of the credit, loan or redemption of the securities and provisions of local government budget.

  18. From regionally predictable to locally complex population structure in a freshwater top predator: River systems are not always the unit of connectivity in Northern Pike Esox lucius

    DEFF Research Database (Denmark)

    Bekkevold, Dorte; Jacobsen, Lene; Hansen, Jakob Hemmer

    2015-01-01

    Contemporary genetic diversity is the product of both historical and contemporary forces, such as climatic and geological processes affecting range distribution and continuously moulded by evolutionary forces selection, gene flow and genetic drift. Predatory freshwater fishes, such as Northern Pike...... structure from local to regional scales is relatively poorly described, in spite of its significance to developing conservation measures. We analysed microsatellite variation in a total of 1185 North European pike from 46 samples collected across both local and regional scales, as well as over time......, to address two overarching questions: Is pike population structure associated with local and/or regional connectivity patterns, and which factors likely have the main influence on the contemporary distribution of genetic diversity? To answer this, we combined estimators of population diversity and structure...

  19. Residential environmental evaluation of local cities considering regional characteristic and personal residential preference-a case study of Saga City,Japan

    Institute of Scientific and Technical Information of China (English)

    GE Jian; HOKAO Kazunori

    2004-01-01

    Questionnaire surveys and subjective evaluations on residential environment were performed in order to grasp the main factors of residential environment of small local cities. The suitable evaluation index system was established, and the regional residential environment characteristics and personal residential preference types were analyzed, so that their influence on residential environment evaluation could be grasped. The results can be applied to the residential environment planning, construction and monitoring of local cities.

  20. A Novel Risk Stratification to Predict Local-Regional Failures in Urothelial Carcinoma of the Bladder After Radical Cystectomy

    International Nuclear Information System (INIS)

    Baumann, Brian C.; Guzzo, Thomas J.; He Jiwei; Keefe, Stephen M.; Tucker, Kai; Bekelman, Justin E.; Hwang, Wei-Ting; Vaughn, David J.; Malkowicz, S. Bruce; Christodouleas, John P.

    2013-01-01

    Purpose: Local-regional failures (LF) following radical cystectomy (RC) plus pelvic lymph node dissection (PLND) with or without chemotherapy for invasive urothelial bladder carcinoma are more common than previously reported. Adjuvant radiation therapy (RT) could reduce LF but currently has no defined role because of previously reported morbidity. Modern techniques with improved normal tissue sparing have rekindled interest in RT. We assessed the risk of LF and determined those factors that predict recurrence to facilitate patient selection for future adjuvant RT trials. Methods and Materials: From 1990-2008, 442 patients with urothelial bladder carcinoma at University of Pennsylvania were prospectively followed after RC plus PLND with or without chemotherapy with routine pelvic computed tomography (CT) or magnetic resonance imaging (MRI). One hundred thirty (29%) patients received chemotherapy. LF was any pelvic failure detected before or within 3 months of distant failure. Competing risk analyses identified factors predicting increased LF risk. Results: On univariate analysis, pathologic stage ≥pT3, <10 nodes removed, positive margins, positive nodes, hydronephrosis, lymphovascular invasion, and mixed histology significantly predicted LF; node density was marginally predictive, but use of chemotherapy, number of positive nodes, type of surgical diversion, age, gender, race, smoking history, and body mass index were not. On multivariate analysis, only stage ≥pT3 and <10 nodes removed were significant independent LF predictors with hazard ratios of 3.17 and 2.37, respectively (P<.01). Analysis identified 3 patient subgroups with significantly different LF risks: low-risk (≤pT2), intermediate-risk (≥pT3 and ≥10 nodes removed), and high-risk (≥pT3 and <10 nodes) with 5-year LF rates of 8%, 23%, and 42%, respectively (P<.01). Conclusions: This series using routine CT and MRI surveillance to detect LF confirms that such failures are relatively common in

  1. A Novel Risk Stratification to Predict Local-Regional Failures in Urothelial Carcinoma of the Bladder After Radical Cystectomy

    Energy Technology Data Exchange (ETDEWEB)

    Baumann, Brian C. [Department of Radiation Oncology, University of Pennsylvania, Philadelphia, Pennsylvania (United States); Guzzo, Thomas J. [Department of Urology, University of Pennsylvania, Philadelphia, Pennsylvania (United States); He Jiwei [Department of Biostatistics and Epidemiology, University of Pennsylvania, Philadelphia, Pennsylvania (United States); Keefe, Stephen M. [Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania (United States); Tucker, Kai; Bekelman, Justin E. [Department of Radiation Oncology, University of Pennsylvania, Philadelphia, Pennsylvania (United States); Hwang, Wei-Ting [Department of Biostatistics and Epidemiology, University of Pennsylvania, Philadelphia, Pennsylvania (United States); Vaughn, David J. [Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania (United States); Malkowicz, S. Bruce [Department of Urology, University of Pennsylvania, Philadelphia, Pennsylvania (United States); Christodouleas, John P., E-mail: christojo@uphs.upenn.edu [Department of Radiation Oncology, University of Pennsylvania, Philadelphia, Pennsylvania (United States)

    2013-01-01

    Purpose: Local-regional failures (LF) following radical cystectomy (RC) plus pelvic lymph node dissection (PLND) with or without chemotherapy for invasive urothelial bladder carcinoma are more common than previously reported. Adjuvant radiation therapy (RT) could reduce LF but currently has no defined role because of previously reported morbidity. Modern techniques with improved normal tissue sparing have rekindled interest in RT. We assessed the risk of LF and determined those factors that predict recurrence to facilitate patient selection for future adjuvant RT trials. Methods and Materials: From 1990-2008, 442 patients with urothelial bladder carcinoma at University of Pennsylvania were prospectively followed after RC plus PLND with or without chemotherapy with routine pelvic computed tomography (CT) or magnetic resonance imaging (MRI). One hundred thirty (29%) patients received chemotherapy. LF was any pelvic failure detected before or within 3 months of distant failure. Competing risk analyses identified factors predicting increased LF risk. Results: On univariate analysis, pathologic stage {>=}pT3, <10 nodes removed, positive margins, positive nodes, hydronephrosis, lymphovascular invasion, and mixed histology significantly predicted LF; node density was marginally predictive, but use of chemotherapy, number of positive nodes, type of surgical diversion, age, gender, race, smoking history, and body mass index were not. On multivariate analysis, only stage {>=}pT3 and <10 nodes removed were significant independent LF predictors with hazard ratios of 3.17 and 2.37, respectively (P<.01). Analysis identified 3 patient subgroups with significantly different LF risks: low-risk ({<=}pT2), intermediate-risk ({>=}pT3 and {>=}10 nodes removed), and high-risk ({>=}pT3 and <10 nodes) with 5-year LF rates of 8%, 23%, and 42%, respectively (P<.01). Conclusions: This series using routine CT and MRI surveillance to detect LF confirms that such failures are relatively common

  2. Regions as vehicles for local interests: the spatial strategies of medieval and modern urban elites in the Netherlands

    NARCIS (Netherlands)

    Terlouw, K.; Weststrate, J.

    2013-01-01

    The importance of an historical perspective on the formation of regions is widely accepted. Academics and regional policy-makers use regional history to explain or legitimise the current political position of particular regions, while history is also widely regarded as an important element in the

  3. Regions as vehicles for local interests: the spatial strategies of medieval and modern urban elites in the Netherlands

    NARCIS (Netherlands)

    Terlouw, K.; Weststrate, J.A.

    2012-01-01

    The importance of an historical perspective on the formation of regions is widely accepted. Academics and regional policy-makers use regional history to explain or legitimise the current political position of particular regions, while history is also widely regarded as an important element in the

  4. Analyzing cloud base at local and regional scales to understand tropical montane cloud forest vulnerability to climate change

    Science.gov (United States)

    Van Beusekom, Ashley E.; González, Grizelle; Scholl, Martha A.

    2017-01-01

    The degree to which cloud immersion provides water in addition to rainfall, suppresses transpiration, and sustains tropical montane cloud forests (TMCFs) during rainless periods is not well understood. Climate and land use changes represent a threat to these forests if cloud base altitude rises as a result of regional warming or deforestation. To establish a baseline for quantifying future changes in cloud base, we installed a ceilometer at 100 m altitude in the forest upwind of the TMCF that occupies an altitude range from ∼ 600 m to the peaks at 1100 m in the Luquillo Mountains of eastern Puerto Rico. Airport Automated Surface Observing System (ASOS) ceilometer data, radiosonde data, and Cloud-Aerosol Lidar and Infrared Pathfinder Satellite Observation (CALIPSO) satellite data were obtained to investigate seasonal cloud base dynamics, altitude of the trade-wind inversion (TWI), and typical cloud thickness for the surrounding Caribbean region. Cloud base is rarely quantified near mountains, so these results represent a first look at seasonal and diurnal cloud base dynamics for the TMCF. From May 2013 to August 2016, cloud base was lowest during the midsummer dry season, and cloud bases were lower than the mountaintops as often in the winter dry season as in the wet seasons. The lowest cloud bases most frequently occurred at higher elevation than 600 m, from 740 to 964 m. The Luquillo forest low cloud base altitudes were higher than six other sites in the Caribbean by ∼ 200–600 m, highlighting the importance of site selection to measure topographic influence on cloud height. Proximity to the oceanic cloud system where shallow cumulus clouds are seasonally invariant in altitude and cover, along with local trade-wind orographic lifting and cloud formation, may explain the dry season low clouds. The results indicate that climate change threats to low-elevation TMCFs are not limited to the dry season; changes in synoptic-scale weather patterns

  5. Prolonged superficial local cryotherapy attenuates microcirculatory impairment, regional inflammation, and muscle necrosis after closed soft tissue injury in rats.

    Science.gov (United States)

    Schaser, Klaus-Dieter; Disch, Alexander C; Stover, John F; Lauffer, Annette; Bail, Herman J; Mittlmeier, Thomas

    2007-01-01

    Closed soft tissue injury induces progressive microvascular dysfunction and regional inflammation. The authors tested the hypothesis that adverse trauma-induced effects can be reduced by local cooling. While superficial cooling reduces swelling, pain, and cellular oxygen demand, the effects of cryotherapy on posttraumatic microcirculation are incompletely understood. Controlled laboratory study. After a standardized closed soft tissue injury to the left tibial compartment, male rats were randomly subjected to percutaneous perfusion for 6 hours with 0.9% NaCL (controls; room temperature) or cold NaCL (cryotherapy; 8 degrees C) (n = 7 per group). Uninjured rats served as shams (n = 7). Microcirculatory changes and leukocyte adherence were determined by intravital microscopy. Intramuscular pressure was measured, and invasion of granulocytes and macrophages was assessed by immunohistochemistry. Edema and tissue damage was quantified by gravimetry and decreased desmin staining. Closed soft tissue injury significantly decreased functional capillary density (240 +/- 12 cm(-1)); increased microvascular permeability (0.75 +/- 0.03), endothelial leukocyte adherence (995 +/- 77/cm(2)), granulocyte (182.0 +/- 25.5/mm(2)) and macrophage infiltration, edema formation, and myonecrosis (ratio: 2.95 +/- 0.45) within the left extensor digitorum longus muscle. Cryotherapy for 6 hours significantly restored diminished functional capillary density (393 +/- 35), markedly decreased elevated intramuscular pressure, reduced the number of adhering (462 +/- 188/cm(2)) and invading granulocytes (119 +/- 28), and attenuated tissue damage (ratio: 1.7 +/- 0.17). The hypothesis that prolonged cooling reduces posttraumatic microvascular dysfunction, inflammation, and structural impairment was confirmed. These results may have therapeutic implications as cryotherapy after closed soft tissue injury is a valuable therapeutic approach to improve nutritive perfusion and attenuate leukocyte

  6. Virulence profile of different phylogenetic groups of locally isolated community acquired uropathogenic E. coli from Faisalabad region of Pakistan

    Directory of Open Access Journals (Sweden)

    Bashir Saira

    2012-08-01

    Full Text Available Abstract Background Uropathogenic E.coli (UPEC are among major pathogens causing urinary tract infections. Virulence factors are mainly responsible for the severity of these emerging infections. This study was planned to investigate the distribution of virulence genes and cytotoxic effects of UPEC isolates with reference to phylogenetic groups (B2, B1, D and A to understand the presence and impact of virulence factors in the severity of infection in Faisalabad region of Pakistan. Methods In this study phylogenetic analysis, virulence gene identification and cytotoxicity of 59 uropathogenic E.coli isolates obtained from non-hospitalized patients was studied. Results Among 59 isolates, phylogenetic group B2 (50% was most dominant followed by groups A, B1 (19% each and D (12%. Isolates present in group D showed highest presence of virulence genes. The prevalence hlyA (37% was highest followed by sfaDE (27%, papC (24%, cnf1 (20%, eaeA (19% and afaBC3 (14%. Highly hemolytic and highly verotoxic isolates mainly belonged to group D and B2. We also found two isolates with simultaneous presence of three fimbrial adhesin genes present on pap, afa, and sfa operons. This has not been reported before and underlines the dynamic nature of these UPEC isolates. Conclusions It was concluded that in local UPEC isolates from non-hospitalized patients, group B2 was more prevalent. However, group D isolates were most versatile as all were equipped with virulence genes and showed highest level of cytotoxicity.

  7. Pharmacokinetics, pharmacodynamics and local tolerance at injection site of marbofloxacin administered by regional intravenous limb perfusion in standing horses.

    Science.gov (United States)

    Lallemand, Elodie; Trencart, Pierre; Tahier, Carine; Dron, Frederic; Paulin, Angelique; Tessier, Caroline

    2013-08-01

    To evaluate pharmacokinetic-pharmacodynamic variables and local tolerance at injection-site of marbofloxacin administered via regional intravenous limb perfusion (RIVLP) in standing horses. Adult horses (n = 6). RIVLP were performed with rubber tourniquets applied to the forelimbs of standing sedated horses. Marbofloxacin (0.67 mg/kg) was randomly injected in 1 forelimb, with the contralateral limb serving as a control (0.9% NaCl solution). Samples of jugular blood and synovial fluid from the radiocarpal joint of the marbofloxacin-perfused limb were collected before and at intervals after RIVLP for determination of drug concentrations. All injection sites were evaluated before, 24 and 48 hours after RIVLP by means of ultrasonographic examination, circumferential measurements and subjective visible inflammation scores by veterinarians unaware of treatment received. No adverse effects associated with the technique or antibiotic were observed. High marbofloxacin concentrations were obtained in the synovial fluid, AUCINF was significantly higher in synovial fluid than in plasma (78.64 ± 49.41 and 2.85 ± 0.60 µg h/mL respectively, P = .028). The efficacy indices, AUC0-24 /MIC90 and Cmaxobs/MIC90 , predicted a favorable outcome in the treatment of synovial fluid infections caused by enterobacteriaceae and Staphylococcus aureus. After RIVLP, there was no statistically significant difference between marbofloxacin-injected and control limbs for lameness, visual inflammation score, limb circumference, and ultrasonographic appearance of the veins. Marbofloxacin injected limbs had a significantly greater subcutaneous thickness, compared with control limbs. These data suggest that RIVLP of marbofloxacin (0.67 mg/kg) could be a safe and effective method for treatment of infections of the distal portion of the limb for susceptible organisms. © Copyright 2013 by The American College of Veterinary Surgeons.

  8. Regional Analysis of Long-term Local and Synoptic Effects on Wind Velocity and Energy Patterns in Complex Terrain

    Science.gov (United States)

    Belu, R.; Koracin, D. R.

    2017-12-01

    Investments in renewable energy are justified in both environmental and economic terms. Climate change risks call for mitigation strategies aimed to reduce pollutant emissions, while the energy supply is facing high uncertainty by the current or future global economic and political contexts. Wind energy is playing a strategic role in the efforts of any country for sustainable development and energy supply security. Wind energy is a weather and climate-dependent resource, having a natural spatio-temporal variability at time scales ranging from fraction of seconds to seasons and years, while at spatial scales is strongly affected by the topography and vegetation. Main objective of the study is to investigate spatio-temporal characteristics of the wind velocity in the Southwest U.S., that are relevant to wind energy assessment, analysis, development, operation, and grid integration, by using long-term multiple meteorological tower observations. Wind velocity data and other meteorological parameters from five towers, located near Tonopah, Nevada, operated between 2003 to 2008, and from three towers are located in Carson Valley, Nevada, operated between 2006 and 2014 were used in this study. Multi-annual wind speed data collected did not show significant increase trends with increasing elevation; the differences are mainly governed by the topographic complexity, including local atmospheric circulations. Auto- and cross-correlations show a strong coherence between the wind speed and direction with slowly decreasing amplitude of the multi-day periodicity with increasing lag periods. Besides pronounced diurnal periodicity at all locations, detrended fluctuation analysis also showed significant seasonal and annual periodicities, and long-memory persistence with similar characteristics. In spite of significant differences in mean wind speeds among the towers, due to location specifics, the relatively high auto- and cross-correlation coefficients among the towers indicate

  9. The role of place branding in local and regional economic development: bridging the gap between policy and practicality

    Directory of Open Access Journals (Sweden)

    Evan Cleave

    2016-01-01

    Full Text Available Place branding has become an increasingly integral part of local and regional economic development strategies in the global competition for business investment. Professional and academic understanding remains limited, however, regarding whether place branding can be classified as a ‘high-road’ policy with substantive and effective merits or a ‘low-road’ policy that is generally inefficient and ineffective at fostering sustainable economic growth. Through the context of business attraction, this study examines whether place branding represents ‘high-road’ policy by comparing what economic development practitioners are doing to create and support their brands against the needs and desires of businesses considering relocation. The research goal is achieved through a series of in-depth interviews with economic development practitioners (n = 25 and private-sector site selectors (n = 10 in the province of Ontario, Canada. Gaps between policy and practicality are identified by comparing the responses of the two groups. Results demonstrate that place branding has the potential to be ‘high-road’ policy given its utility in business attraction. In its current implementation, however, place branding remains better described as a ‘low-road’ policy, as it is not being used efficiently. Several gaps in place-branding policy are identified, including an overreliance on visual identities and narratives, poor communication of the brand information, and overemphasis on presenting quality of life and affordability. These gaps present possible areas of ineffectiveness that can limit the ability of a place brand to attract investment, but provide areas of future policy improvements, thus enabling place branding to shift from ‘low road’ to ‘high road’.

  10. Air-quality in the mid-21st century for the city of Paris under two climate scenarios; from regional to local scale

    OpenAIRE

    K. Markakis; M. Valari; A. Colette; O. Sanchez; O. Perrussel; C. Honore; R. Vautard; Z. Klimont; S. Rao

    2014-01-01

    Ozone and PM2.5 concentrations over the city of Paris are modeled with the CHIMERE air-quality model at 4 km × 4 km horizontal resolution for two future emission scenarios. High-resolution (1 km × 1 km) emission projection until 2020 for the greater Paris region is developed by local experts (AIRPARIF) and is further extended to year 2050 based on regional scale emission projections developed by the Global Energy Assessment. Model evaluation is performed bas...

  11. Ductile and brittle structural evolution of the Laxemar-Simpevarp area: an independent analysis based on local and regional constraints

    International Nuclear Information System (INIS)

    Viola, Giulio

    2008-10-01

    This report discusses the main aspects of the ductile and brittle deformational evolution of the Laxemar-Simpevarp area. Based on the interpretation of existing potential field geophysical data, it is suggested that the structural ductile grain of the region is controlled by large, c. EW trending shear zones with an overall sinistral strike-slip kinematics. The Oskarshamn Shear Zone (OSZ) and the Mederhult lineament are two examples of these shear zones and it is proposed that the ductile lineaments mapped in Laxemar-Simpevarp are genetically linked to shearing accommodated by these shear zones. The structural interpretation of the geophysical imagery of the Laxemar-Simpevarp regional model area and the available meso-scale structural information indicate that the Laxemar-Simpevarp study area can be interpreted as the analogue of a large-scale S/C' structural pattern. In detail, the Aespoe shear zone and other similarly oriented ductile shears represent C' shear bands that deform sinistrally the intervening EW lineaments (the S surfaces), which locally are significantly crenulated/folded in response to their asymptotic bending into the C' shears. This geometric and kinematic interpretation implies that, in contrast to existing reconstructions and models, EW- and not NE-trending shear zones become the main structural ductile feature of the region. Shear forces acting parallel to these main zones can successfully explain all the ductile structures described and reported from the area. The greatest compressive stress at the time of ductile shearing would trend NE-SW. The brittle deformation history of the region is complex and results from the multiple reactivation of fracture- and fault sets caused by the many orogenic episodes that affected the area during 1.5 Gyr of geological brittle evolution. Fault-slip data from outcrops and oriented drill cores were used to compute paleo-stress states. In the general absence of time markers that help constrain the relative

  12. Ductile and brittle structural evolution of the Laxemar-Simpevarp area: an independent analysis based on local and regional constraints

    Energy Technology Data Exchange (ETDEWEB)

    Viola, Giulio (Geological Survey of Norway, Trondheim (Norway))

    2008-10-15

    This report discusses the main aspects of the ductile and brittle deformational evolution of the Laxemar-Simpevarp area. Based on the interpretation of existing potential field geophysical data, it is suggested that the structural ductile grain of the region is controlled by large, c. EW trending shear zones with an overall sinistral strike-slip kinematics. The Oskarshamn Shear Zone (OSZ) and the Mederhult lineament are two examples of these shear zones and it is proposed that the ductile lineaments mapped in Laxemar-Simpevarp are genetically linked to shearing accommodated by these shear zones. The structural interpretation of the geophysical imagery of the Laxemar-Simpevarp regional model area and the available meso-scale structural information indicate that the Laxemar-Simpevarp study area can be interpreted as the analogue of a large-scale S/C' structural pattern. In detail, the Aespoe shear zone and other similarly oriented ductile shears represent C' shear bands that deform sinistrally the intervening EW lineaments (the S surfaces), which locally are significantly crenulated/folded in response to their asymptotic bending into the C' shears. This geometric and kinematic interpretation implies that, in contrast to existing reconstructions and models, EW- and not NE-trending shear zones become the main structural ductile feature of the region. Shear forces acting parallel to these main zones can successfully explain all the ductile structures described and reported from the area. The greatest compressive stress at the time of ductile shearing would trend NE-SW. The brittle deformation history of the region is complex and results from the multiple reactivation of fracture- and fault sets caused by the many orogenic episodes that affected the area during 1.5 Gyr of geological brittle evolution. Fault-slip data from outcrops and oriented drill cores were used to compute paleo-stress states. In the general absence of time markers that help constrain

  13. Mosquito politics: local vector control policies and the spread of West Nile Virus in the Chicago region.

    Science.gov (United States)

    Tedesco, Carmen; Ruiz, Marilyn; McLafferty, Sara

    2010-11-01

    Differences in mosquito control practices at the local level involve the interplay of place, scale and politics. During the Chicago West Nile Virus (WNV) outbreak of 2002, mosquito abatement districts represent distinct suburban clusters of human WNV cases, independent of characteristics of the local population, housing and physical environment. We examine how the contrasting actions of four districts reveal a distinct local politics of mosquito control that may have contributed to local-scale geographic differences in WNV incidence. This politics is rooted in political, economic and philosophical differences within and between administrative boundaries. Copyright © 2010 Elsevier Ltd. All rights reserved.

  14. The conserved 12-amino acid stretch in the inter-bromodomain region of BET family proteins functions as a nuclear localization signal.

    Science.gov (United States)

    Fukazawa, Hidesuke; Masumi, Atsuko

    2012-01-01

    The bromodomain and extraterminal (BET) family is a group of chromatin-binding proteins characterized by two bromodomains, an extraterminal (ET) domain, and several other conserved regions of unknown function. In humans, the BET family consists of four members, BRD2, BRD3, BRD4 and BRDT, that all normally localize to the nucleus. We identified a 12-amino acid stretch in the inter-bromodomain region that is perfectly conserved among the BET family members. We deleted these residues and expressed the mutant proteins in HEK293T cells to investigate the function of this motif. We found that the deletion of this motif alters the localization of BET proteins. Mutated BRD3 and BRD4 were excluded from the nucleus, and BRDT was found to be diffused throughout the nucleus and cytoplasm. Although the mutant BRD2 remained predominantly in the nucleus, a punctate distribution was also observed in the cytosol. It has been reported that a conserved motif between the second bromodomain and the ET domain serves as a nuclear localization signal for BRD2. Nevertheless, BET mutants lacking the reported nuclear localization signal motif but retaining the 12-amino acid stretch resided in the nucleus. Furthermore, these mutants were diffused throughout the cytoplasm when the 12 residues were removed. These results indicate that the conserved amino acid stretch in the inter-bromodomain region of the BET family functions as a nuclear localization signal.

  15. Reports from dissemination and feed-back workshops with presentation of Volante results from WP1 and WP2, and response from local, regional, and national stakeholders

    DEFF Research Database (Denmark)

    Frederiksen, Pia; Vesterager, Jens Peter; Kristensen, Søren Bech Pilgaard

    2014-01-01

    The report constitutes an overview of the dissemination and feed-back workshops in the Volante case study countries: Netherlands, Romania, Austria, Greece and Denmark. The workshops were conducted based on the presentation of findings from WP1 and WP2 to national, regional and local stakeholders...

  16. Implementation of a guideline for local health policy making by regional health services : Exploring determinants of use by a web survey

    NARCIS (Netherlands)

    Kuunders, T.J.M.; Jacobs, M.A.M.; Paulussen, T.G.W.M.; van de Goor, L.A.M.; van Bon, M.J.H.; van Oers, J.A.M.

    Background Previous evaluation showed insufficient use of a national guideline for integrated local health policy by Regional Health Services (RHS) in the Netherlands. The guideline focuses on five health topics and includes five checklists to support integrated municipal health policies. This study

  17. Implementation of a guideline for local health policy making by regional health services: exploring determinants of use by a web survey

    NARCIS (Netherlands)

    Kuunders, T.J.M.; Jacobs, M.A.M.; Goor, I.A.M. van de; Bon-Martens, M.J.H. van; Oers, H.A.M. van; Paulussen, T.G.W.M.

    2017-01-01

    Background. Previous evaluation showed insufficient use of a national guideline for integrated local health policy by Regional Health Services (RHS) in the Netherlands. The guideline focuses on five health topics and includes five checklists to support integrated municipal health policies. This

  18. Application of Remote-Sensing Observations for Detecting Patterns of Localization of Cu-Ni Mineralization of the Norilsk Ore Region

    Science.gov (United States)

    Milovsky, G. A.; Ishmukhametova, V. T.; Shemyakina, E. M.

    2017-12-01

    The methods of a complex analysis of materials of space, gravimetric, and magnetometric surveys were developed on the basis of a study of reference fields of the Norilsk ore region (Imangda, etc.) for detection patterns of the localization of Cu-Ni (with PGMs) mineralization in intrusive complexes of the northwestern frame of the Siberian Platform.

  19. Distinguishing regional and local sources of pollution by trace metals and magnetic particles in fluvial sediments of the Morava River, Czech Republic

    Czech Academy of Sciences Publication Activity Database

    Nováková, Tereza; Matys Grygar, Tomáš; Bábek, O.; Famera, M.; Mihaljevič, M.; Strnad, L.

    2013-01-01

    Roč. 13, č. 2 (2013), s. 460-473 ISSN 1439-0108 Institutional support: RVO:61388980 Keywords : Enrichment factors * Fluvial sediments * Heavy metals * Local sources * Normalisation * Regional contamination Subject RIV: DD - Geochemistry Impact factor: 2.107, year: 2013

  20. European integration and the supervision of local and regional authorities
    Experiences in the Netherlands with requirements of European Community law

    Directory of Open Access Journals (Sweden)

    Bart Hessel

    2006-06-01

    Full Text Available As a result of increasing European integration, local and regional authorities are having to deal with European law more and more intensively. As Member States (read: central government are responsible vis-à-vis the Community for the errors of local and regional authorities, the question arises within Member States whether the central government possesses sufficient supervisory instruments for complying with their obligations under Community law: they must ensure that the errors of local and regional authorities are rectified in time, and national law must provide for sufficient possibilities to do so. Although Community law is neutral towards the internal relations between the various tiers of government within the Member States, this responsibility of the central government may, as a result of European integration, lead to a need for more powerful supervisory instruments in relation to local and regional authorities. In the past five years there has been some debate on this subject within the Netherlands and after a long delay the Dutch cabinet in 2004 decided that the existing supervisory instruments in the decentralized unitary state of the Netherlands should be expanded. The legislation intended to realize this expansion is being prepared. This discussion and its results would seem of interest to other Member States of the Community facing similar problems.

  1. CO{sub 2} Sequestration Capacity and Associated Aspects of the Most Promising Geologic Formations in the Rocky Mountain Region: Local-Scale Analyses

    Energy Technology Data Exchange (ETDEWEB)

    Laes, Denise; Eisinger, Chris; Morgan, Craig; Rauzi, Steve; Scholle, Dana; Scott, Phyllis; Lee, Si-Yong; Zaluski, Wade; Esser, Richard; Matthews, Vince; McPherson, Brian

    2013-07-30

    The purpose of this report is to provide a summary of individual local-­scale CCS site characterization studies conducted in Colorado, New Mexico and Utah. These site-­ specific characterization analyses were performed as part of the “Characterization of Most Promising Sequestration Formations in the Rocky Mountain Region” (RMCCS) project. The primary objective of these local-­scale analyses is to provide a basis for regional-­scale characterization efforts within each state. Specifically, limits on time and funding will typically inhibit CCS projects from conducting high-­ resolution characterization of a state-­sized region, but smaller (< 10,000 km{sup 2}) site analyses are usually possible, and such can provide insight regarding limiting factors for the regional-­scale geology. For the RMCCS project, the outcomes of these local-­scale studies provide a starting point for future local-­scale site characterization efforts in the Rocky