Sample records for mcdonald observatory ids
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McDONALD OBSERVATORY ARCHIVE OF OPTICAL LINEAR POLARIZATION MEASUREMENTS
International Nuclear Information System (INIS)
Wills, Beverley J.; Wills, D.; Breger, M.
2011-01-01
We present 990 previously unpublished optical linear polarization measurements of quasars, active galactic nuclei, and some stars observed for interstellar polarization. The observations, covering the period 1981-2000, were made with McDonald Observatory's 2.1 m Struve reflector and the Breger photopolarimeter.
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The McDonald Observatory lunar laser ranging project
Silverberg, E. C.
1978-01-01
A summary of the activities of the McDonald lunar laser ranging station at Fort Davis for the FY 77-78 fiscal year is presented. The lunar laser experiment uses the observatory 2.7m reflecting telescope on a thrice-per-day, 21-day-per-lunation schedule. Data are recorded on magnetic tapes and sent to the University of Texas at Austin where the data is processed. After processing, the data is distributed to interested analysis centers and later to the National Space Science Data Center where it is available for routine distribution. Detailed reports are published on the McDonald operations after every fourth lunation or approximately once every 115 days. These reports contain a day-by-day documentation of the ranging activity, detailed discussions of the equipment development efforts, and an abundance of other information as is needed to document and archive this important data type.
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Supernova observations at McDonald Observatory
International Nuclear Information System (INIS)
Wheeler, J.C.
1984-01-01
The programs to obtain high quality spectra and photometry of supernovae at McDonald Observatory are reviewed. Spectra of recent Type I supernovae in NGC 3227, NGC 3625, and NGC 4419 are compared with those of SN 1981b in NGC 4536 to quantitatively illustrate both the homogeneity of Type I spectra at similar epochs and the differences in detail which will serve as a probe of the physical processes in the explosions. Spectra of the recent supernova in NGC 0991 give for the first time quantitative confirmation of a spectrally homogeneous, but distinct subclass of Type I supernovae which appears to be less luminous and to have lower excitation at maximum light than classical Type I supernovae
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The night sky brightness at McDonald Observatory
Kalinowski, J. K.; Roosen, R. G.; Brandt, J. C.
1975-01-01
Baseline observations of the night sky brightness in B and V are presented for McDonald Observatory. In agreement with earlier work by Elvey and Rudnick (1937) and Elvey (1943), significant night-to-night and same-night variations in sky brightness are found. Possible causes for these variations are discussed. The largest variation in sky brightness found during a single night is approximately a factor of two, a value which corresponds to a factor-of-four variation in airglow brightness. The data are used to comment on the accuracy of previously published surface photometry of M 81.
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MLRS - A lunar/artificial satellite laser ranging facility at the McDonald Observatory
Shelus, P. J.
1985-01-01
Experience from lunar and satellite laser ranging experiments carried out at McDonald Observatory has been used to design the McDonald Laser Ranging Station (MLRS). The MLRS is a dual-purpose installation designed to obtain observations from the LAGEOS satellite and lunar targets. The instruments used at the station include a telescope assembly 0.76 meters in diameter; a Q-switched doubled neodymium YAG laser with a pulse rate of three nanoseconds; and a GaAs photodetector with Fabry-Perot interferometric filter. A functional diagram of the system is provided. The operating parameters of the instruments are summarized in a table.
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HD 91669B: A NEW BROWN DWARF CANDIDATE FROM THE MCDONALD OBSERVATORY PLANET SEARCH
International Nuclear Information System (INIS)
Wittenmyer, Robert A.; Endl, Michael; Cochran, William D.; Ramirez, Ivan; MacQueen, Phillip J.; Shetrone, Matthew; Reffert, Sabine
2009-01-01
We report the detection of a brown dwarf candidate orbiting the metal-rich K dwarf HD 91669, based on radial-velocity data from the McDonald Observatory Planet Search. HD 91669b is a substellar object in an eccentric orbit (e = 0.45) at a separation of 1.2 AU. The minimum mass of 30.6M Jup places this object firmly within the brown dwarf desert for inclinations i ∼> 23 0 . This is the second rare close-in brown dwarf candidate discovered by the McDonald planet search program.
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2011 Astronomy Day at McDonald Observatory
Preston, Sandra; Hemeway, M.; Wetzel, M.
2012-01-01
Our philosophy is that everyday is Astronomy Day because the McDonald Observatory's Frank N. Bash Visitors Center is open 362 days a year. So, how did we create a special celebration for the "Astronomy Day” declared by the Astronomical League? During September 26-29 we conducted 20 videoconferences and served 12,559 students with "Astronomy Day” programming. Connect2Texas provides bridging for a network of Texas-based museums and cultural, historical, and scientific organizations that offer educational content to schools throughout the state via videoconferencing. Connect2Texas connected McDonald Observatory to 334 schools; most of these schools were in Texas, but schools in a dozen other states also participated. While most schools had a "view-only" connection, at least 20 of the schools had interactive connections, whereby the students could ask questions of the presenter. Connect2Texas also collects evaluation information from the participating schools that we will use to produce a report for our funders and make modifications to future programs as need be. The videoconferences were offered free of charge. The theme for the 2011 Astronomy Day program was the Year of the Solar System, which aligns with NASA's theme for 2011 and 2012. By aligning with this NASA theme, we could leverage NASA artwork and materials to both advertise and enrich the learning experience. Videoconference materials also included pre- and post-videoconference assessment sheets, an inquiry based activity, and pre- and post-videoconference activities, all of which were made available online. One of the lessons learned from past Astronomy Day videoconferences is that the days the Astronomical League declares as "Astronomy Day” are not always good days for Texas schools to participate. So, we choose an Astronomy Day that meets the needs of Texas schools and our schedule - so any day can be Astronomy Day. 2011 Astronomy Day was made possible by The Meyer-Levy Charitable Trust.
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A continued program of planetary study at the University of Texas McDonald Observatory
Trafton, L.
1991-01-01
The program conducts solar system research in support of NASA missions and of general astronomical interest. Investigations of composition, physical characteristics and changes in solar system bodies are conducted primarily using the facilities of McDonald Observatory. Progress, accomplishments, and projected accomplishments are discussed.
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Report on the lunar ranging at McDonald Observatory, 1 February - 31 May 1976
Palm, C. S.; Wiant, J. R.
1976-01-01
The four spring lunations produced 105 acquisitions, including the 2000th range measurement made at McDonald Observatory. Statistics were normal for the spring months. Laser and electronics problems are noted. The Loran-C station delay was corrected. Preliminary doubles data is shown. New magnetic tape data formats are presented. R and D efforts include a new laser modification design.
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Stellar Radial Velocities with IGRINS at McDonald Observatory
Mace, Gregory; Jaffe, Daniel; Park, Chan; Lee, Jae-Joon
2016-06-01
Exoplanet searches with dedicated instrumentation have made 1 m/s radial velocity (RV) precision routine.Yet, RVs for large samples of stars generally remain at the 1km/s level.TheImmersion Grating Infrared Spectrometer (IGRINS) is a revolutionary instrument that exploits broad spectral coverage at high-resolution in the near-infrared.IGRINS on the 2.7 meter Harlan J. Smith Telescope at McDonald Observatory is nearly as sensitive as CRIRES at the 8 meter Very Large Telescope. However, IGRINS at R=45,000 has more than 30 times the spectral grasp of CRIRES.The use of a silicon immersion grating facilitates a compact cryostat while providing simultaneous wavelength coverage from 1.45 - 2.45 microns. Wehave developed a pipeline to cross-correlate the more than 20,000 resolution elements in two IGRINS exposures and provide relative RVs with uncertainties of 50m/s (product for multi-epoch studies of low-mass, stellar and substellar multiplicity.
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Cochran, William D.; Hatzes, Artie P.
1993-01-01
The McDonald Observatory Planetary Search program surveyed a sample of 33 nearby F, G, and K stars since September 1987 to search for substellar companion objects. Measurements of stellar radial velocity variations to a precision of better than 10 m/s were performed as routine observations to detect Jovian planets in orbit around solar type stars. Results confirm the detection of a companion object to HD114762.
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The Results of an Era of Teacher Professional Development at McDonald Observatory
Finkelstein, K. D.; Hemenway, M. K.; Preston, S.; Wetzel, M.; Meyer, J.; Rood, M.
2014-07-01
During the past decade, McDonald Observatory has been developing and refining its Teacher Professional Development Workshops, many of which have been supported by NASA. Metrics include attendance, perceived knowledge gain, and readiness to apply what was learned in the classroom. Evaluations show impact through the classroom application at five to six months after the workshops and through consistently high positive workshop results. This paper will show that a) our Teacher Professional Development Workshops are consistently well attended, b) the workshops improve teachers' confidence and their understanding of concepts, c) teachers enjoy unique interactions with astronomers and engineers, d) teachers appreciate hands-on and inquiry-based activities that are modeled and tied to state and national standards, and e) many teachers experience using the activities in their classrooms with good results.
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Mcdonald Observatory 9P/TEMPEL 1 Data V1.0
Cochran, A. L.; Barker, E. S.; Caballero, M. D.; Gyorgey-Ries, J.
2010-01-01
We report on low-spectral resolution observations of comet 9P/Tempel 1 from 1983, 1989, 1994 and 2005 using the 2.7m Harlan J. Smith telescope of McDonald Observatory. This comet was the target of NASA's Deep Impact mission and our observations allowed us to characterize the comet prior to the impact. In the published paper, we showed that the comet decreased in gas production from 1983 to 2005, with the decrease being different factors for different species. OH decreased by a factor 2.7, NH by 1.7, CN by 1.6, C3 by 1.8, CH by 1.4 and C2 by 1.3. Despite the decrease in overall gas production and these slightly different decrease factors, we found that the ratios of the gas production rates of OH, NH, C3, CH and C2 that of CN were constant over all of the apparitions. We saw no change in the production rate ratios after the impact. We found that the peak gas production occurred about two months prior to perihelion. This data set represents the integrated fluxes and column densities, mentioned in the published paper, which were used to derive the production rates in the paper.
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Thirty years of cometary spectroscopy from McDonald Observatory
Cochran, A. L.; Barker, E. S.; Gray, C. L.
2012-03-01
We report on the results of a spectroscopic survey of 130 comets that was conducted at McDonald Observatory from 1980 through 2008. Some of the comets were observed on only one night, while others were observed repeatedly. For 20 of these comets, no molecules were detected. For the remaining 110 comets, some emission from CN, OH, NH, C3, C2, CH, and NH2 molecules were observed on at least one occasion. We converted the observed molecular column densities to production rates using a Haser (Haser, L. [1957]. Liege Inst. Astrophysics Reprint No. 394) model. We defined a restricted data set of comets that had at least three nights of observations. The restricted data set consists of 59 comets. We used ratios of production rates to study the trends in the data. We find two classes of comets: typical and carbon-chain depleted comets. Using a very strict definition of depleted comets, requiring C2and C3 to both be depleted, we find 9% of our restricted data set comets to be depleted. Using a more relaxed definition that requires only C2 to be below a threshold (similar to other researchers), we find 25% of the comets are depleted. Two-thirds of the depleted comets are Jupiter Family comets, while one-third are Long Period comets. 37% of the Jupiter Family comets are depleted, while 18.5% of the Long Period comets are depleted. We compare our results with other studies and find good agreement.
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Arthur B. McDonald, Physics Nobel Laureate 2015, at CERN colloquium
Ordan, Julien Marius
2017-01-01
Arthur B. McDonald, Physics Nobel Laureate 2015, photographed at CERN colloquium on the "Science of the Sudbury Neutrino Observatory (SNO) and SNOLAB” given in CERN Main Auditorium on Monday 4 Sep 2017
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Tull, Robert G.; Macqueen, Phillip J.; Sneden, Christopher; Lambert, David L.
1995-01-01
A new high-resolution cross-dispersed echelle spectrometer has been installed at the coude focus of the McDonald Observatory 2.7-m telescope. Its primary goal was simultaneously to gather spectra over as much of the spectral range 3400 A to 1 micrometer as practical, at a resolution R identical with lambda/Delta lambda which approximately = 60,000 with signal-to-noise ratio of approximately 100 for stars down to magnitude 11, using 1-h exposures. In the instrument as built, two exposures are all that are needed to cover the full range. Featuring a white-pupil design, fused silica prism cross disperser, and folded Schmidt camera with a Tektronix 2048x2048 CCD used at either of two foci, it has been in regularly scheduled operation since 1992 April. Design details and performance are described.
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Preston, Sandra; Cianciolo, F.; Jones, T.; Wetzel, M.; Mace, K.; Barrick, R.; Kelton, P.; Cochran, A.; Johnson, R.
2007-05-01
Of the 100,000 visitors that come to McDonald Observatory each year, about half of them visit the Harlan J. Smith 2.7-m Telescope. Visitors experience the 2.7-m telescope as part of a guided tour, a self-guided tour, and during the once-a-month special viewing nights, that are unique to a telescope this size. Recent safety requirements limiting visitor access to the dome-floor level and a need to modernize out-of-date displays in the 2.7-m lobby area, motivated us to do this new exhibit. A planning team consisting of McDonald Observatory personnel from Outreach & Education, Physical Plant, and Administration came together via videoconferences (between Austin and Fort Davis) to develop an exhibit for the lobby area of this telescope. As the planning process unfolded, the team determined that a mix of static displays and modern technology such as flat panel displays and DVD video were key to presenting the history of the facility, introducing basic concepts about the telescope and current research, as well as giving virtual access to the dome floor for visitors on the self-guided tour. This approach also allows for content development and much of production to be done in-house, which was important from both a cost and maintenance standpoint. A representative of the Smith family was also consulted throughout the development of the exhibit to insure that the exhibit plan was seen as an acceptable memorial to the late director. The exhibit was installed in January 2007.
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McDonald 2.1-m and CRTS Photometry of Eclipsing Polars
Wells, Natalie; Mason, Paul
2018-01-01
We present broadband optical photometry of five polars made using the 2.1-m telescope of McDonald Observatory. Four of the polars are eclipsing (EP Dra, FL Cet, V2301 Oph, and a Catalina Sky Survey (CSS) polar candidate). In addition, a pre-polar (MQ Dra) was observed. Typical integration times were 1-3 seconds with no dead time. At this time resolution, eclipse structure can be seen in both one- and two-pole accretors. McDonald 2.1-m data over several years is phased together with CSS photometry covering up to 7 years, in search of indications of period variation. Combining the high-resolution, high-speed photometry obtained using the ProEm camera on the McDonald 2.1-m with the sparse, but high-quality multi-year baseline photometry of the CSS places strong constraints on the time variability of the eclipse periods in these binary systems. In most cases, eclipse variations do not perfectly fit a linear ephemeris. We investigate the source of variations using standard O-C diagram techniques and period search algorithms.
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Smith, H. J.
1986-01-01
McDonald Observatory of the University of Texas at Austin reports on its activities during the period 1 Jan. 1986 to 30 June 1986. Extensive observations of Halley's Comet were obtained. The comet exhibited large variability; moreover, its variability was much more rapid than can be accounted for by water vaporization as the sole controller of activity. Jupiter satellite Io's atmosphere was found to be distended by more than the equilibrium scale height but less than for unimpeded streaming into space. The atmosphere is at least temporarily bound to IO. Uranus' (3-0) H2 quadrupole line shapes require a modification of Baines and Bergstralh's standard model which incorporates at high altitude absorbing haze in addition to the lower haze layer. A fraction of normal H2 equal to 0.25 + or 0.10 is derived, in good agreement with the standard model. This result is unchanged when the preliminary temperature structure derived by the Voyager Radio Occultation Experiment is used instead of Appleby's model c. Out of the six Pluto-Charon mutual events observed this year, data were obtained on four. Preliminary analysis is yielding improved estimates for the diameters, masses, densities, and albedos of these objects.
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International Nuclear Information System (INIS)
Robertson, Paul; Endl, Michael; Cochran, William D.; MacQueen, Phillip J.; Brugamyer, Erik J.; Barnes, Stuart I.; Caldwell, Caroline; Wittenmyer, Robert A.; Horner, J.; Simon, Attila E.
2012-01-01
We present high-precision radial velocity (RV) observations of four solar-type (F7-G5) stars—HD 79498, HD 155358, HD 197037, and HD 220773—taken as part of the McDonald Observatory Planet Search Program. For each of these stars, we see evidence of Keplerian motion caused by the presence of one or more gas giant planets in long-period orbits. We derive orbital parameters for each system and note the properties (composition, activity, etc.) of the host stars. While we have previously announced the two-gas-giant HD 155358 system, we now report a shorter period for planet c. This new period is consistent with the planets being trapped in mutual 2:1 mean-motion resonance. We therefore perform an in-depth stability analysis, placing additional constraints on the orbital parameters of the planets. These results demonstrate the excellent long-term RV stability of the spectrometers on both the Harlan J. Smith 2.7 m telescope and the Hobby-Eberly telescope.
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Performance of the Zeeman analyzer system of the McDonald Observatory 2.7 meter telescope
Vogt, S. S.; Tull, R. G.; Kelton, P. W.
1980-01-01
The paper describes a multichannel photoelectric Zeeman analyzer at the coude spectrograph of the McDonald 2.7 m reflector. A comparison of Lick and McDonald observations of HD 153882 reveals no significant difference in slopes or zero points of the two magnetic fields indicating that the systematic scale difference of 30-40% is probably instrumental in origin. Observations of the magnetic variable beta Cor Bor revealed a more nearly sinusoidal magnetic curve with less internal scatter than the photographically determined field measures of the Lick and Mauna Kea Zeeman systems. Investigation of periodicity in the secularly varying magnetic minima of beta Cor Bor did not yield evidence of previously noted periodicities other than that expected from the time structure of the data sampling.
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Pengaruh Terpaan Komunikasi Pemasaran Menu Breakfast Mcdonald"s Keputusan Pembelian
Tasuki, Martia Mutiara; Pradekso, Tandiyo; Ulfa, Nurist Surayya
2013-01-01
PENGARUH TERPAAN KOMUNIKASI PEMASARAN MENU BREAKFAST MCDONALD'S DAN CITRA PRODUK TERHADAP KEPUTUSAN PEMBELIANSkripsiDisusun untuk memenuhi persyaratan menyelesaikanPendidikan Strata IJurusan Ilmu Komunikasi Fakultas Ilmu Sosial dan Ilmu PolitikUniversitas DiponegoroPenyusunNama : Martia Mutiara TasukiNIM : D2C 005 183JURUSAN ILMU KOMUNIKASIFAKULTAS ILMU SOSIAL DAN ILMU POLITIKUNIVERSITAS DIPONEGOROSEMARANG2013PENGARUH TERPAAN KOMUNIKASI PEMASARAN MENU BREAKFAST MCDONALD'S DAN CITRA PRODUK TER...
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Cochran, A. L.; Barker, E. S.; Caballero, M. D.; Györgey-Ries, J.
2009-01-01
We report on low-spectral resolution observations of Comet 9P/Tempel 1 from 1983, 1989, 1994 and 2005 using the 2.7 m Harlan J. Smith telescope of McDonald Observatory. This comet was the target of NASA's Deep Impact mission and our observations allowed us to characterize the comet prior to the impact. We found that the comet showed a decrease in gas production from 1983 to 2005, with the decrease being different factors for different species. OH decreased by a factor 2.7, NH by 1.7, CN by 1.6, C 3 by 1.8, CH by 1.4 and C 2 by 1.3. Despite the decrease in overall gas production and these slightly different decrease factors, we find that the gas production rates of OH, NH, C 3, CH and C 2 ratioed to that of CN were constant over all of the apparitions. We saw no change in the production rate ratios after the impact. We found that the peak gas production occurred about two months prior to perihelion. Comet Tempel 1 is a "normal" comet.
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The Coude spectrograph and echelle scanner of the 2.7 m telescope at McDonald observatory
Tull, R. G.
1972-01-01
The design of the Coude spectrograph of the 2.7 m McDonald telescope is discussed. A description is given of the Coude scanner which uses the spectrograph optics, the configuration of the large echelle and the computer scanner control and data systems.
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A description of the lunar ranging station at McDonald Observatory.
Silverberg, E. C.; Currie, D. G.
1972-01-01
The equipment of this station which has been in operation since the deployment of the first corner reflector by the Apollo 11 astronauts. The McDonald 2.7-m telescope is used for both transmission and reception of pulsed ruby laser light during three 45-minute daily laser runs about three weeks in a month. The present laser pulse width, timing system, calibration procedures, and signal levels are designed to achieve ranging with an accuracy to 1 nanosecond. The data rates obtained since September, 1970, are consistent with the scientific commitments of the lunar ranging program. Most of the over 200 acquisitions obtained have an accuracy to better than plus or minus 30 cm. Details of the telescope matching optics, guiding and timing equipment, and calibration procedures are discussed. Representative lunar range data are included.
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Adolescent Purchasing Behavior at McDonald's and Subway.
Lesser, Lenard I; Kayekjian, Karen C; Velasquez, Paz; Tseng, Chi-Hong; Brook, Robert H; Cohen, Deborah A
2013-10-01
To assess whether adolescents purchasing food at a restaurant marketed as "healthy" (Subway) purchase fewer calories than at a competing chain (McDonald's). We studied 97 adolescents who purchased a meal at both restaurants on different days, using each participant as his or her control. We compared the difference in calories purchased by adolescents at McDonald's and Subway in a diverse area of Los Angeles, CA. Adolescents purchased an average of 1,038 calories (standard error of the mean [SEM]: 41) at McDonald's and 955 calories (SEM 39) at Subway. The difference of 83 calories (95% confidence interval [CI]: -20 to 186) was not statistically significant (p = .11). At McDonald's, participants purchased significantly more calories from drinks (151 vs. 61, p McDonald's vs. 35 at Subway, p McDonald's (.15 vs. .57 cups, p McDonald's. Although Subway meals had more vegetables, meals from both restaurants are likely to contribute to overeating. Copyright © 2013 Society for Adolescent Health and Medicine. Published by Elsevier Inc. All rights reserved.
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A Cluster Of Activities On Coma From The Hubble Space Telescope, StarDate, And McDonald Observatory
Hemenway, Mary Kay; Jogee, S.; Fricke, K.; Preston, S.
2011-01-01
With a goal of providing a vast audience of students, teachers, the general public, and Spanish-speakers with activities to learn about research on the Coma cluster of galaxies based on the HST ACS Treasury survey of Coma, McDonald Observatory used a many-faceted approach. Since this research offered an unprecedented legacy dataset, part of the challenge was to convey the importance of this project to a diverse audience. The methodology was to create different products for different (overlapping) audiences. Five radio programs were produced in English and Spanish for distribution on over 500 radio stations in the US and Mexico with a listening audience of over 2 million; in addition to the radio listeners, there were over 13,000 downloads of the English scripts and almost 6000 of the Spanish. Images were prepared for use in the StarDate Online Astronomy Picture of the Week, for ViewSpace (used in museums), and for the StarDate/Universo Teacher Guide. A high-school level activity on the Coma Cluster was prepared and distributed both on-line and in an upgraded printed version of the StarDate/Universo Teacher Guide. This guide has been distributed to over 1700 teachers nationally. A YouTube video about careers and research in astronomy using the Coma cluster as an example was produced. Just as the activities were varied, so were the evaluation methods. This material is based upon work supported by the National Aeronautics and Space Administration under Grant/Contract/Agreement No. HST-EO-10861.35-A issued through the Space Telescope Science Institute, which is operated by the Association of Universities for Research in Astronomy, Inc., under NASA contract NAS5-26555.
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The McDonaldization of Higher Education.
Hayes, Dennis, Ed.; Wynyard, Robin, Ed.
The essays in this collection discuss the future of the university in the context of the "McDonaldization" of society and of academia. The idea of McDonaldization, a term coined by G. Ritzer (1998), provides a tool for looking at the university and its inevitable changes. The chapters are: (1) "Enchanting McUniversity: Toward a…
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McDonaldization and Job Insecurity
Directory of Open Access Journals (Sweden)
Emeka W. Dumbili
2013-06-01
Full Text Available The article examines how and why the McDonaldization of banking system in Nigeria engenders job insecurity. This is imperative because it provides an explicit revelation of the root causes of job insecurity in the sector that other scholars have totally omitted. No Nigerian scholar has applied the thesis in relation to job insecurity, which is the major problem in Nigeria’s banking industry. The article based on the analysis of secondary data and observations, therefore, draws on McDonaldization thesis to examine the upsurge of rationalization in the sector since consolidation exercise began in 2005. The article argues that the sector’s rising rationalization and ensuing efficiency, calculability, predictability, and control are necessary. However, these have inevitably engendered job insecurity and its adverse consequences. Based on the critical analyses of available evidence, the article concludes that the best option is to commence resistance of the McDonaldization processes, especially those that replace human with nonhuman technology or make customers unpaid workers.
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Fast Food McDonald's China Fix
Institute of Scientific and Technical Information of China (English)
DAVID HENDRICKSON
2006-01-01
@@ Since the opening of its first outlet 16 years ago, McDonald's China operation has on many levels proven enormously successful.Home to more than 750 locations nationwide, the Middle Kingdom today ranks as one of McDonald's ten largest markets,with returns hovering in doubles digits and raking in billions annually. As lucrative as it may be, however, China has nonetheless developed into a relative sore spot for the world's leading fast food giant.
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Improving queuing service at McDonald's
Koh, Hock Lye; Teh, Su Yean; Wong, Chin Keat; Lim, Hooi Kie; Migin, Melissa W.
2014-07-01
Fast food restaurants are popular among price-sensitive youths and working adults who value the conducive environment and convenient services. McDonald's chains of restaurants promote their sales during lunch hours by offering package meals which are perceived to be inexpensive. These promotional lunch meals attract good response, resulting in occasional long queues and inconvenient waiting times. A study is conducted to monitor the distribution of waiting time, queue length, customer arrival and departure patterns at a McDonald's restaurant located in Kuala Lumpur. A customer survey is conducted to gauge customers' satisfaction regarding waiting time and queue length. An android app named Que is developed to perform onsite queuing analysis and report key performance indices. The queuing theory in Que is based upon the concept of Poisson distribution. In this paper, Que is utilized to perform queuing analysis at this McDonald's restaurant with the aim of improving customer service, with particular reference to reducing queuing time and shortening queue length. Some results will be presented.
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Experience in Collaboration: McDenver at McDonald's.
Combs, Clarice Sue
2002-01-01
The McDenver at McDonald's project provided a nontraditional, community-based teaching and learning environment for faculty and students in a health, physical education, and recreation (HPER) department and a school of nursing. Children and parents come to McDonald's, children received developmental screenings, and parents completed conferences…
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Comet Giacobini-Zinner - a normal comet?
International Nuclear Information System (INIS)
Cochran, A.L.; Barker, E.S.
1987-01-01
Observations of Comet Giacobini-Zinner were obtained during its 1985 apparition using an IDS spectrograph at McDonald Observatory. Column densities and production rates were computed. The production rates were compared to observations of other normal comets. Giacobini-Zinner is shown to be depleted in C2 and C3 relative to CN. These production rates are down by a factor of 5. 12 references
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Postavení firmy McDonald's na trhu v USA
Holkupová, Jitka
2012-01-01
This thesis deals with McDonald's and its current position in the U.S. market. The first chapter focuses on the company's history from the very beginnings to the present. It explains what was behind the success of McDonald's and how the company is different from most competitors. The second chapter focuses on the current situation in the U.S. market, the role of franchising in the fast food industry and McDonald's compared with its main competitors. The subject of the third chapter is the SWO...
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Potential effects of the next 100 billion hamburgers sold by McDonald's.
Spencer, Elsa H; Frank, Erica; McIntosh, Nichole F
2005-05-01
McDonald's has sold >100 billion beef-based hamburgers worldwide with a potentially considerable health impact. This paper explores whether there would be any advantages if the next 100 billion burgers were instead plant-based burgers. Nutrient composition of the beef hamburger patty and the McVeggie burger patty were obtained from the McDonald's website; sales data were obtained from the McDonald's customer service. Consuming 100 billion McDonald's beef burgers versus the same company's McVeggie burgers would provide, approximately, on average, an additional 550 million pounds of saturated fat and 1.2 billion total pounds of fat, as well as 1 billion fewer pounds of fiber, 660 million fewer pounds of protein, and no difference in calories. These data suggest that the McDonald's new McVeggie burger represents a less harmful fast-food choice than the beef burger.
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Application of the McDonald MRI criteria in multiple sclerosis.
Chan, Ling Ling; Sitoh, Yih Yian; Chong, June; See, Siew Ju; Umapathi, Thirugnanam N; Lim, Shih Hui; Ong, Benjamin
2007-08-01
The aim of this study was to assess the sensitivity of McDonald's magnetic resonance imaging (MRI) criteria for the diagnosis of multiple sclerosis (MS) in a group of Asian patients diagnosed with clinically definite MS, based on lesion characterisation on MRI scans. Forty-nine patients from 3 major neurological institutions were classified as having Asian- or Western-type MS based on clinical assessment. Each MRI scan was reviewed by 2 neuroradiologists for the presence and characteristics of brain and spinal lesions. The McDonald's MRI criteria were then applied and its sensitivity evaluated. Nine patients were excluded, leaving 34 females and 6 males who were dominantly Chinese (90%), with a mean age of 36.2 years. The MRI brain and spinal findings were detailed and tabulated. Statistically significant differences (P McDonald's MRI criteria were found between our Asian- and Western-type MS patients. The diagnostic yield of McDonald's MRI criteria increased by 20% when we substituted a cord for a brain lesion, and applied the substitution for enhancing cord lesions as well. The diagnosis is more likely to be made when using McDonald MRI criteria based on brain findings, in a patient who presents clinically with Western-type MS. The provision for substitution of "one brain for a spinal lesion" is helpful in Asian-type MS, where there is preponderance of spinal lesion load. Our findings suggest that minor modifications in the interpretation of McDonald's MRI criteria have significant impact on the diagnosis in patients clinically presenting as Asian-type MS, with potential bearing on their subsequent management.
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Comparative Study of McDonald's and Kentucky Fried Chicken (KFC) development in China
Xie, Yuanyuan; Hu, Wei
2013-01-01
Abstract McDonald's and KFC are two international fast food restaurants. They both expended their businesses in global scale. It is obvious that McDonald surpassed KFC in terms of sales and fame in international level. However, in China, KFC performs better than McDonald's. The aim of this study is to find out how these two companies developed differently in Chinese market. By making a comparative study of McDonald's and KFC, different operation and competitive strategy theory will be...
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The McDonaldization of Nigerian Universities
Directory of Open Access Journals (Sweden)
Emeka W. Dumbili
2014-04-01
Full Text Available This article examines the extent to which the deregulation of Nigerian higher education (HE has facilitated the McDonaldization of the universities. University education in Nigeria commenced in 1948 with the establishment of the University College, Ibadan. After independence in 1960, subsequent governments expanded the number of universities, a policy based on a lack of quality manpower in leadership positions created by the exit of British officials and the need to grant access to an increasing number of prospective students. In the 1970s, the number of universities increased accompanied by a decline in infrastructure, funding, and working conditions. This resulted in several strikes and an exodus of academics to other countries. Instead of tackling the problems, the federal government shifted responsibilities by approving private ownership of universities in 1999 and by establishing the National Open University of Nigeria (NOUN in 2001. Against this backdrop, this article critically analyzes how some of these reforms facilitated the McDonaldization of Nigerian universities. The article reveals how this has resulted in an overloading of responsibilities on the faculty, erosion of academic autonomy, a prioritization of quantity over quality of publications, and an assumption of “customer” status by students. The article uses evidence from McDonaldized HE in Western countries to discuss the implications of these developments and suggests some remedial measures.
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Headrick, Robert J., Jr.
This booklet is intended for classroom use in first-year high school French to acquaint students with the McDonald's fast food restaurants in Paris. The specific objectives are for the student to: (1) discuss the similarities and differences between the American and Parisian McDonald's, (2) set up a miniature McDonald's in the classroom, (3) order…
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The McDonald Modified Weibull Distribution: Properties and Applications
Merovci, Faton; Elbatal, Ibrahim
2013-01-01
A six parameter distribution so-called the McDonald modified Weibull distribution is defined and studied. The new distribution contains, as special submodels, several important distributions discussed in the literature, such as the beta modified Weibull, Kumaraswamy modified Weibull, McDonald Weibull and modified Weibull distribution,among others. The new distribution can be used effectively in the analysis of survival data since it accommodates monotone, unimodal and bathtub-shaped hazard fu...
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Bridge Suture for Successful McDonald Emergency Cerclage.
Tanaka, Masaaki; Hori, Yoshiaki; Shirafuji, Aya; Kato, Mitsunori; Kato, Jyun; Kobayashi, Hiroto; Tsuchida, Toru; Fukae, Tsukasa
2017-01-01
To create awareness about a surgical technique termed bridge suture, which is performed as a pretreatment before a McDonald cerclage is performed on an emergency to treat severe cervical insufficiency. Procedures for bridge suture were reviewed in detail and outcomes of 16 patients treated with bridge suture followed by McDonald cerclage were evaluated retrospectively. Using the bridge suture, the edges of uterine cervix were temporarily sutured and the external uterine os was closed, while the hourglass-shaped fetal membranes were concomitantly confined within the cervix; subsequently, a McDonald cerclage was performed. Over a 22-year period, 16 patients with a dilated cervix and bulging fetal membranes were treated using the technique of bridge suture followed by an emergency cerclage. The mean gestational age at cerclage was 22.5 weeks; the mean gestational age at delivery was 30.7 weeks; and the mean interval between cerclage and delivery was 8.2 weeks. In 15 out of 16 cases, cerclage was performed without encountering any complications. No maternal complications, including cervical laceration, were observed. The mean body weight of 17 neonates, including that of a twin, was 1,516 g and of them, 15 neonates survived. The important outcome of bridge suture is the replacement of fetal membranes back into the uterine cavity before McDonald's cerclage is performed. Pretreatment with bridge suture may facilitate the performance of a successful emergency cerclage and contribute to good maternal and neonatal outcomes. © 2016 S. Karger AG, Basel.
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Vnímanie značky McDonald's na českom trhu
Harčár, Tomáš
2015-01-01
The bachelor thesis explores perception of the brand McDonald's on the Czech market. The objective of this thesis is to test via questionnaire an assumption, which is based on belief that customers find food sold in McDonald's restaurant unhealthy and of poor quality. The thesis contains a theoretic part which presents a basic definition linked to brand building and brand image. Those definitions are further used to explain advertising strategy of McDonald's company. Concluding chapter evalua...
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Texas-Style Fundraising and Public Relations for the International Year of Astronomy
Preston, S.; Barna, J. W.; Johnson, R.; Geiger, S.; Rimm, N.; Watson, K.; Griffin, J.
2008-11-01
McDonald Observatory will use the International Year of Astronomy (IYA) celebration to strengthen its fundraising for science education and outreach programs. At the same time, McDonald Observatory will be undergoing a logo and branding campaign in order to better unite the work and relationship of the University of Texas Department of Astronomy, McDonald Observatory, and the Observatory's education and outreach programs.
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The Mcdonaldization of Academic Libraries and the Values of Transformational Change
Nicholson, Karen P.
2015-01-01
In his article "The McDonaldization of Academic Libraries?" Brian Quinn explores to what extent and to what effect academic libraries have become "McDonaldized," according to the concept developed by sociologist George Ritzer. Quinn identifies a number of ways in which the four dimensions of…
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Hesburger asub ründama, McDonalds teeb kaevikuid / Andres Reimer
Reimer, Andres
2005-01-01
Hesburger tahab Eestis oma restoranide hulka kolmekordistada. McDonald's Eestis ei laiene, kuid kavatseb ettevõtte efektiivsust suurendada. Eesti hamburgerirestoranide kett Nehatu on konkurentsist välja langenud. Tabelid: Tulemused; Hamburgerirestoranid Eestis; Hamburger ja McDonald's maailmas. Lisad: Hakkas Hesburgeri partneriks; Hakka McDonald'si partneriks
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Assessing the health impact of transnational corporations: a case study on McDonald's Australia.
Anaf, Julia; Baum, Frances E; Fisher, Matt; Harris, Elizabeth; Friel, Sharon
2017-02-06
The practices of transnational corporations affect population health through production methods, shaping social determinants of health, or influencing the regulatory structures governing their activities. There has been limited research on community exposures to TNC policies and practices. Our pilot research used McDonald's Australia to test methods for assessing the health impacts of one TNC within Australia. We adapted existing Health Impact Assessment methods to assess McDonald's activities. Data identifying potential impacts were sourced through document analysis, including McDonald's corporate literature; media analysis and semi-structured interviews. We commissioned a spatial and socioeconomic analysis of McDonald's restaurants in Australia through Geographic Information System technology. The data was mapped against a corporate health impact assessment framework which included McDonald's Australia's political and business practices; products and marketing; workforce, social, environmental and economic conditions; and consumers' health related behaviours. We identified both positive and detrimental aspects of McDonald's Australian operations across the scope of the CHIA framework. We found that McDonald's outlets were slightly more likely to be located in areas of lower socioeconomic status. McDonald's workplace conditions were found to be more favourable than those in many other countries which reflects compliance with Australian employment regulations. The breadth of findings revealed the need for governments to strengthen regulatory mechanisms that are conducive to health; the opportunity for McDonald's to augment their corporate social responsibility initiatives and bolster reputational endorsement; and civil society actors to inform their advocacy towards health and equity outcomes from TNC operations. Our study indicates that undertaking a corporate health impact assessment is possible, with the different methods revealing sufficient information to
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Directory of Open Access Journals (Sweden)
Isleide Arruda Fontenelle
2006-08-01
Full Text Available Objetiva-se apresentar e discutir as relações atuais entre imagem e entretenimento a partir de pesquisas realizadas sobre a construção da imagem de marca McDonald's e sobre as modernas técnicas de marketing. Visando compreender porque nos tornamos consumidores de imagens, procurou-se recuperar, a partir da própria historia do McDonald's, os acontecimentos econômicos, sociais, culturais, políticos, que teriam nos transformado em uma sociedade na qual "estar na imagem é existir". Embora trágica em seu sentido de fundo, essa perda da forma nos é compensada por imagens de diversão e felicidade que as marcas nos transmitem. Ao final, questiona-se o alcance global dessa promessa a partir de uma digressão sobre o Brasil: como a marca McDonald's nos fornece as imagens para uma certa constituição identitária; e o seu nome para um sentimento de permanência? Como falar de "identificação" com uma marca que, aparentemente, não teria uma relação histórica e cultural com o Brasil?This article presents and discusses the current relationship between image and entertainment, based on the results of research studies on the constitution of McDonald's' brand image all over the world and contemporary marketing. Aiming to understand why we have become image consumers, those studies tried to recover, based on McDonald's history, economical, social, cultural, and political events that have lead us towards an obsessed image society, in which, "being in the image is the same as existing". Although tragic in its bottom line, that inexistence of form is compensated to us by amusement and happiness images conveyed by the brands. Finally, the research questions the global reach of that promise, starting from a digression on Brazil: how does McDonald's' brand supply us images for a certain identity constitution; and its brand name for a permanence feeling? How is it possible to speak of "identification" with a brand that, seemingly, would not have a
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Headrick, Robert J., Jr.
This booklet is intended for classroom use in first-year high school Spanish to acquaint students with the McDonald's fast food restaurants in Costa Rica. The specific objectives are for the student to: (1) discuss the similarities and differences between the American and Costa Rican McDonald's, (2) set up a miniature McDonald's in the classroom,…
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Twenty Years of Precise Radial Velocities at Keck and Lick Observatories
Wright, J. T.
2015-10-01
The precise radial velocity survey at Keck Observatory began over 20 years ago. Its survey of thousands of stars now has the time baseline to be sensitive to planets with decade-long orbits, including Jupiter analogs. I present several newly-finished orbital solutions for long-period giant planets. Although hot Jupiters are generally ``lonely'' (i.e. they are not part of multiplanet systems), those that are not appear to often have giant companions at 5 AU or beyond. I present two of the highest period-ratios among planets in a two-planet system, and some of the longest orbital periods ever measured for exoplanets. In many cases, combining Keck radial velocities from those from other long-term surveys at Lick Observatory, McDonald Observatory, HARPS, and, of course, OHP spectrographs, produces superior orbital fits, constraining both period and eccentricity better than could be possible with any single set alone. Stellar magnetic activity cycles can masquerade as long-period planets. In most cases this effect is very small, but a loud minority of stars, including, apparently, HD 154345, show very strong RV-activity correlations.
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McDonald's vs Father Christmas
Pratt, Dave; Simpson, Amanda
2004-01-01
Mathematics in textbooks and indeed in conventional classrooms is often presented as exercises or worksheets in which the mathematics itself has been processed into a form that is easily digested. This McDonald's version of mathematics ensures that the mathematical skill or technique is laid bare and typically the sole focus of attention. In this…
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McDonaldization, Islamic teachings, and funerary practices in Kuwait.
Iqbal, Zafar
2011-01-01
Drawing on George Ritzer's sociological concept of McDonaldization, this article explores the transformation of burial practices in Kuwait. It is argued that traditional, religious, and private ways of dealing with death have been modernized using the fast-food model of McDonald's. This article examines Islamic teachings on burial and how that model has been applied to the traditional Muslim funerary services, including cemetery management, grave excavation, funeral prayers, burial, and condolences, to make them more efficient vis-a-vis more profitable. Based on personal observations and random interviews, the study finds that the state bureaucracy in Kuwait has made burial rituals more efficient, standardized, calculable, and controlled. Furthermore, several associated irrationalities are also considered. Findings suggest that some individuals may not be happy with these changes but there is no popular resistance to McDonaldization of the burial practices, probably due to the authoritarian and welfare nature of the State of Kuwait.
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LASSO observations at McDonald and OCA/CERGA: A preliminary analysis
Veillet, CH.; Fridelance, P.; Feraudy, D.; Boudon, Y.; Shelus, P. J.; Ricklefs, R. L.; Wiant, J. R.
1993-01-01
The Laser Synchronization from Synchronous Orbit (LASSO) observations between USA and Europe were made possible with the move of Meteosat 3/P2 toward 50 deg W. Two Lunar Laser Ranging stations participated into the observations: the MLRS at McDonald Observatory (Texas, USA) and OCA/CERGA (Grasse, France). Common sessions were performed since 30 Apr. 1992, and will be continued up to the next Meteosat 3/P2 move further West (planned for January 1993). The preliminary analysis made with the data already collected by the end of Nov. 1992 shows that the precision which can be obtained from LASSO is better than 100 ps, the accuracy depending on how well the stations maintain their time metrology, as well as on the quality of the calibration (still to be made.) For extracting such a precision from the data, the processing has been drastically changed compared to the initial LASSO data analysis. It takes into account all the measurements made, timings on board, and echoes at each station. This complete use of the data increased dramatically the confidence into the synchronization results.
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Weinstein, Margery
2012-01-01
Who isn't familiar with McDonald's? Its golden arches are among the most recognizable brand icons in the U.S. What many are less familiar with is the methodical and distinguished learning and development that supports that brand. Training that begins by preparing employees to serve customers at the counter, and extends to programs that help…
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Kornek, Barbara; Schmitl, Beate; Vass, Karl; Zehetmayer, Sonja; Pritsch, Martin; Penzien, Johann; Karenfort, Michael; Blaschek, Astrid; Seidl, Rainer; Prayer, Daniela; Rostasy, Kevin
2012-12-01
Magnetic resonance imaging diagnostic criteria for paediatric multiple sclerosis have been established on the basis of brain imaging findings alone. The 2010 McDonald criteria for the diagnosis of multiple sclerosis, however, include spinal cord imaging for detection of lesion dissemination in space. The new criteria have been recommended in paediatric multiple sclerosis. (1) To evaluate the 2010 McDonald multiple sclerosis criteria in children with a clinically isolated syndrome and to compare them with recently proposed magnetic resonance criteria for children; (2) to assess whether the inclusion of spinal cord imaging provided additional value to the 2010 McDonald criteria. We performed a retrospective analysis of brain and spinal cord magnetic resonance imaging scans from 52 children with a clinically isolated syndrome. Sensitivity, specificity and accuracy of the magnetic resonance criteria were assessed. The 2010 McDonald dissemination in space criteria were more sensitive (85% versus 74%) but less specific (80% versus 100%) compared to the 2005 McDonald criteria. The Callen criteria were more accurate (89%) compared to the 2010 McDonald (85%), the 2005 McDonald criteria for dissemination in space (81%), the KIDMUS criteria (46%) and the Canadian Pediatric Demyelinating Disease Network criteria (76%). The 2010 McDonald criteria for dissemination in time were more accurate (93%) than the dissemination in space criteria (85%). Inclusion of the spinal cord did not increase the accuracy of the McDonald criteria.
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The McDonaldization of Academic Libraries?
Quinn, Brian
2000-01-01
Discusses the McDonaldization thesis that suggests that many aspects of the fast food industry are making their way into other areas of society. Explores whether this thesis is applicable to academic libraries, focusing on efficiency, calculability, predictability, control, user expectations, pros and cons of teams, and creativity and information…
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Verhoeven, P.
2015-01-01
In this essay the perspective of Ritzer's McDonaldization of Society Thesis is the starting point for developing hypotheses about corporate communication (CorpCom). The central idea of McDonaldization is that increasing numbers of organizations are run as fast food restaurants, focusing on:
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McDonaldization and Job Insecurity
Emeka W. Dumbili
2013-01-01
The article examines how and why the McDonaldization of banking system in Nigeria engenders job insecurity. This is imperative because it provides an explicit revelation of the root causes of job insecurity in the sector that other scholars have totally omitted. No Nigerian scholar has applied the thesis in relation to job insecurity, which is the major problem in Nigeria’s banking industry. The article based on the an...
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McDonald's restaurants and neighborhood deprivation in Scotland and England.
Cummins, Steven C J; McKay, Laura; MacIntyre, Sally
2005-11-01
Features of the local fast food environment have been hypothesized to contribute to the greater prevalence of obesity in deprived neighborhoods. However, few studies have investigated whether fast food outlets are more likely to be found in poorer areas, and those that have are local case studies. In this paper, using national-level data, we examine the association between neighborhood deprivation and the density of McDonald's restaurants in small census areas (neighborhoods) in Scotland and England. Data on population, deprivation, and the location of McDonald's Restaurants were obtained for 38,987 small areas in Scotland and England (6505 "data zones" in Scotland, and 32,482 "super output areas" in England) in January 2005. Measures of McDonald's restaurants per 1000 people for each area were calculated, and areas were divided into quintiles of deprivation. Associations between neighborhood deprivation and outlet density were examined during February 2005, using one-way analysis of variance in Scotland, England, and both countries combined. Statistically significant positive associations were found between neighborhood deprivation and the mean number of McDonald's outlets per 1000 people for Scotland (p<0.001), England (p<0.001), and both countries combined (p<0.001). These associations were broadly linear with greater mean numbers of outlets per 1000 people occurring as deprivation levels increased. Observed associations between presence or absence of fast food outlets and neighborhood deprivation may provide support for environmental explanations for the higher prevalence of obesity in poor neighborhoods.
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Market Entry Strategies : Case: McDonald's entry on the Russian market
Karataev, Oleg
2015-01-01
The thesis considers the entry strategy and development of the company McDonald's into international markets. The theoretical aspects of the entry strategy of the company into the international markets. Analyzes the key features of the development of McDonald's in Russia. Investigated the prospects of the company in international markets. In theoretic part there was regarded some important aspects of international strategic management, such as: strategic alternatives, elements and levels o...
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A Comparative Study of McDonald's Wedding Narratives with the Model of Anchoring
Huang, Mimi
2016-01-01
Fast-food giant McDonald's announced in 2010 that they would start hosting wedding ceremonies and receptions for couples who would like to get married in their restaurants in Hong Kong. This paper conducts a study comparing the differing representations of McDonald's wedding services through a narrative analytical approach. Specifically, this…
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VizieR Online Data Catalog: Follow-up of probable young star ASASSN-15qi (Herczeg+, 2016)
Herczeg, G. J.; Dong, S.; Shappee, B. J.; Chen, P.; Hillenbrand, L. A.; Jose, J.; Kochanek, C. S.; Prieto, J. L.; Stanek, K. Z.; Kaplan, K.; Holoien, T.-S.; Mairs, S.; Johnstone, D.; Gully-Santiago, M.; Zhu, Z.; Smith, M. C.; Bersier, D.; Mulders, G. D.; Filippenko, A. V.; Ayani, K.; Brimacombe, J.; Brown, J. S.; Connelley, M.; Harmanen, J.; Itoh, R.; Kawabata, K. S.; Maehara, H.; Takata, K.; Yuk, H.; Zheng, W.
2017-02-01
The outburst of ASASSN-15qi (2MASS J22560882+5831040) occurred on JD2457298 (2015 October 2; UTC dates are used herein). The All-Sky Automated Survey for Supernovae (ASAS-SN) is an all-sky V-band transient survey with a limiting magnitude of ~17. ASAS-SN photometry of ASASSN-15qi was obtained from two different telescopes on Haleakala, Hawaii with intervals of one to three days. ASAS-SN photometry is listed in Table 2. Archival photometry, ground-based optical photometry with Las Cumbres Observatory Global Telescope Network (LCOGT) 1m telescope at McDonald Observatory between 2015 October 23 and December 23 and at the Liverpool Telescope on 2016 April 26 and June 11, Swift/UVOT photometry on 2015 October 12 (ID 00034098001) and 2015 December 27 (ID 00034098002), NIR photometry with the NOTCam camera at the Nordic Optical Telescope (NOT) on 2015 December 22 and Spitzer/IRAC MIR photometry on 2006 December 29 (Program ID 30734, PI Donald Figer) and James Clerk Maxwell Telescope (JCMT) SCUBA2 submillimeter observations of ASASSN-15qi on 2015 November 5 and optical and NIR spectroscopy observations are also described in section 2. (1 data file).
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Zipoli, V; Portaccio, E; Siracusa, G; Pracucci, G; Sorbi, S; Amato, M P
2003-10-01
We assessed the interobserver agreement on the diagnosis of multiple sclerosis (MS) in a study sample consisting of 41 MS (15 relapsing remitting, two secondary progressive, five primary progressive and 19 presenting their first clinical attack) and three non-MS cases. Clinical and paraclinical information was recorded in standardized forms. Four neurologists were asked to make a diagnosis using Poser's and McDonald's criteria and to assess MRI scans according to the McDonald's guidelines. In terms of the kappa statistic (kappa), we found a moderate agreement on the overall diagnosis using both Poser's and McDonald's criteria (kappa, respectively 0.57 and 0.52). As for distinct diagnostic categories, we observed a moderate to substantial agreement for the three McDonald categories (range of kappa values 0.49-0.64) and a fair to substantial agreement for the nine Poser categories (range of kappa values 0.37-0.67). Taking into account clinical information, the agreement on dissemination over time was substantially higher (kappa = 0.69) than that found on dissemination over space (kappa = 0.46). In contrast, for MRI assessment, the agreement for spatial dissemination was substantial (kappa = 0.74) compared with the fair agreement (kappa = 0.25) yielded by dissemination over time. The new McDonald's criteria yield a good overall diagnostic reliability, and compare favourably with Poser's classification in terms of agreement on distinct diagnostic categories.
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Brief Analysis On Different Organizational Behaviors Between Wal-Mart and McDonald's
Institute of Scientific and Technical Information of China (English)
全毅文
2009-01-01
@@ At present, increasing companies appeared on the market, and market is just like a big melting furnace. If company can not lay out themselves, company will be eliminated. Many of companies are out of use in the market, but the Walmart and McDonald's talented showing itself in numerous markets and held water in this melting furnace. And how did they achieve their success? General speaking, the organizational structure, culture and perfect management are the most important factors for the two companies. In my report, I will use the Walmart and McDonald's case and compare the two companies' different cultures, structures and managements, and begin to describe the three areas. First chapter will talk about companies' background. Second part will describe the comparison of companies. And third chapter will discuss the development of companies. Now we will walk into the world of Walmart and McDonald, and experience the success of the two enterprises jointly.
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Nadolny, Andrew; Ryan, Suzanne
2015-01-01
The McDonaldization of higher education refers to the transformation of universities from knowledge generators to rational service organizations or "McUniversities". This is reflected in the growing dependence on a casualized academic workforce. The article explores the extent to which the McDonaldization thesis applies to universities…
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Semiotic Analysis Of Mcdonald's Printed Advertisement
URAIDA, SITI
2014-01-01
Keywords: Semiotic, printed advertisement, sign, icon, symbol, index, connotation, myth Printed advertisement has a promotional function as medium to advertise aproduct. It implicitly persuades people to create demand of product which is being advertised. In this study, the writer uses printed advertisement of McDonald's fast food company as the object. The printed advertisement was analyzed by usingSemiotics study. There are seven printed advertisements that were analyzes in this study. All ...
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Africano, J.; De Vaucouleurs, G.; Evans, D. S.; Finkel, B. E.; Nather, R. E.; Palm, C.; Silverberg, E.; Wiant, J.; Hubbard, W. B.; Jokipii, J. R.
1977-01-01
An analysis of observations of the occultation of Epsilon Gem by Mars on April 8, 1976, is presented. The data were obtained by three neighboring telescopes at McDonald Observatory. Intensity fluctuations on time scales of the order of 100 ms were observed simultaneously at the three telescopes. As the observations compare well with predictions of turbulent scintillation theory, it is concluded that such fluctuations were probably largely the effect of stellar scintillations in the Martian atmosphere. The stellar diameter is included as a parameter in the theory but in a way which differs from previously published interpretations of occultations of extended sources by planetary atmospheres. Scintillations govern the experimental uncertainty in the deduction of the scale height of the high Martian atmosphere. A density scale height of 9.9 + or - 2.5 km is obtained at an altitude of 74 + or - 8 km above the mean surface. For CO 2 gas, this result corresponds to a temperature of 190 + or - 50 K.
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LENUS (Irish Health Repository)
Albertyn, Christine
2012-02-01
BACKGROUND: The revised McDonald criteria aim to simplify and speed the diagnosis of multiple sclerosis (MS). An important principle of the criteria holds there should be no better explanation for the clinical presentation. In Miller et al.\\'s consensus statement on the differential diagnosis of MS, red flags are identified that may suggest a non-MS diagnosis. OBJECTIVE: All new patients with a practice diagnosis of MS were assessed for compliance with McDonald criteria. The group of patients not fulfilling criteria was followed up to assess compliance over time. At the end of the follow-up period, red flags were sought in the group of patients who remained McDonald criteria negative. METHODS: Clinical notes and paraclinical tests were examined retrospectively for compliance with McDonald criteria and for the presence of red flags. RESULTS: Sixty-two patients were identified, with two lost to follow-up. Twenty-six (42%) patients fulfilled criteria at diagnosis. After 53 months follow-up, 47 (78%) patients fulfilled criteria. In the 13 (22%) patients who remain McDonald criteria negative, a total of 20 red flags were identified, ranging from one to six per patient. Alternative diagnoses were considered and further investigations performed in 10 patients with no significantly abnormal results. CONCLUSION: Twenty-two percent of patients still do not fulfill McDonald criteria after 53 months. Dissemination in time was not proven in the majority of patients and the lack of follow-up neuroimaging was an important factor in this. Red flags may be useful in identifying alternative diagnoses, but the yield was low in our cohort.
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[Revision of McDonald's new diagnostic criteria for multiple sclerosis].
Wiendl, H; Kieseier, B C; Gold, R; Hohlfeld, R; Bendszus, M; Hartung, H-P
2006-10-01
In 2001, an international panel suggested new diagnostic criteria for multiple sclerosis (MS). These criteria integrate clinical, imaging (MRI), and paraclinical results in order to facilitate diagnosis. Since then, these so-called McDonald criteria have been broadly accepted and widely propagated. In the meantime a number of publications have dealt with the sensitivity and specificity for MS diagnosis and with implementing these new criteria in clinical practice. Based on these empirical values and newer data on MS, an international expert group recently proposed a revision of the criteria. Substantial changes affect (1) MRI criteria for the dissemination of lesions over time, (2) the role of spinal cord lesions in the MRI and (3) diagnosis of primary progressive MS. In this article we present recent experiences with the McDonald and revised criteria.
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Sponzorský projekt McDonald's Olympic Hopefuls na podporu mladých sportovců.
Adamec, Richard
2008-01-01
This thesis is devoted to the McDonald's Olympic Hopefuls sponsorship project. The first two parts include theoretical essentials for elaboration and the terms concerning marketing. Explanation of terms related to marketing communication and commercial communications is also included in this section. The third part is focused on sponsorship, its types and evaluation of sponsorship projects. The application part describes the history of the McDonald's Olympic Hopefuls project. Evaluation of th...
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Submarine geology and geomorphology of active Sub-Antarctic volcanoes: Heard and McDonald Islands
Watson, S. J.; Coffin, M. F.; Whittaker, J. M.; Lucieer, V.; Fox, J. M.; Carey, R.; Arculus, R. J.; Bowie, A. R.; Chase, Z.; Robertson, R.; Martin, T.; Cooke, F.
2016-12-01
Heard and McDonald Islands (HIMI) are World Heritage listed sub-Antarctic active volcanic islands in the Southern Indian Ocean. Built atop the Kerguelen Plateau by Neogene-Quaternary volcanism, HIMI represent subaerial exposures of the second largest submarine Large Igneous Province globally. Onshore, processes influencing island evolution include glaciers, weathering, volcanism, vertical tectonics and mass-wasting (Duncan et al. 2016). Waters surrounding HIMI are largely uncharted, due to their remote location. Hence, the extent to which these same processes shape the submarine environment around HIMI has not been investigated. In early 2016, we conducted marine geophysical and geologic surveys around HIMI aboard RV Investigator (IN2016_V01). Results show that volcanic and sedimentary features prominently trend east-west, likely a result of erosion by the eastward flowing Antarctic Circumpolar Current and tidal currents. However, spatial patterns of submarine volcanism and sediment distribution differ substantially between the islands. >70 sea knolls surround McDonald Island suggesting substantial submarine volcanism. Geophysical data reveals hard volcanic seafloor around McDonald Island, whereas Heard Island is characterised by sedimentary sequences tens of meters or more thick and iceberg scours - indicative of glacial processes. Differences in submarine geomorphology are likely due to the active glaciation of Heard Island and differing rock types (Heard: alkali basalt, McDonald: phonolite), and dominant products (clastics vs. lava). Variations may also reflect different magmatic plumbing systems beneath the two active volcanoes (Heard produces larger volumes of more focused lava, whilst McDonald extrudes smaller volumes of more evolved lavas from multiple vents across the edifice). Using geophysical data, corroborated with new and existing geologic data, we present the first geomorphic map revealing the processes that shape the submarine environment around HIMI.
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Thornton, Lukar E; Ball, Kylie; Lamb, Karen E; McCann, Jennifer; Parker, Kate; Crawford, David A
2016-05-01
Neighbourhood food environments are posited as an important determinant of eating behaviours; however causality is difficult to establish based on existing studies. Using a natural experiment study design (incorporating repeated cross-sectional data), we tested whether the development of a new McDonald's restaurant increased the frequency of consumption of McDonald's products amongst local residents in the suburbs of Tecoma (site of a new McDonald's restaurant development) and Monbulk (control site) in Victoria, Australia. Across both sites, the reported frequency of McDonald's consumption did not change during the follow-up surveys. In the context explored, the development of a new McDonald's restaurant has not resulted in an increased consumption of McDonald's products. Copyright © 2016 Elsevier Ltd. All rights reserved.
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Training for QSC: How McDonald's Makes Library Managers.
Aycock, Anthony
2001-01-01
Written by a former McDonald's manager who earned a master's degree in library science, this article describes how "QSC"--quality, services, and cleanliness--can be applied to libraries in the same way it is used by restaurants. Argues that libraries are simply businesses that cater to customers. (Contains 42 references.) (NB)
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The world of Ronald McDonald: on the trademark and the mediatic sociality
Fontenelle, Isleide Arruda
2002-01-01
O palhaço Ronald McDonald -- uma das imagens de marca da Corporação McDonald's -- é tomado como paradigma para pensarmos as relações entre mercado, mídia e entretenimento, as quais tem uma ligação direta com o que estamos conceituando como "socialidade midiática". Enquanto uma metáfora ideal de uma propaganda que parece não querer mais fazer sentido, a história do palhaço nos permite desvendar os sentidos contidos em duas das principais práticas do marketing moderno, a propaganda e a publicid...
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International Nuclear Information System (INIS)
Sharma, Pankaj; Patel, Divya; Chaudhary, Jaideep
2012-01-01
As transcriptional regulators of basic helix–oop–helix (bHLH) transcription and non-bHLH factors, the inhibitor of differentiation (Id1, Id2, Id3, and Id4) proteins play a critical role in coordinated regulation of cell growth, differentiation, tumorigenesis, and angiogenesis. Id1 regulates prostate cancer (PCa) cell proliferation, apoptosis, and androgen independence, but its clinical significance in PCa remains controversial. Moreover, there is lack of evidence on the expression of Id2 and Id3 in PCa progression. In this study we investigated the expression of Id2 and Id3 and reevaluated the expression of Id1 in PCa. We show that increased Id1 and Id3 protein expression is strongly associated with increasing grade of PCa. At the molecular level, we report that silencing either Id1 or Id3 attenuates cell cycle. Although structurally and mechanistically similar, our results show that both these proteins are noncompensatory at least in PCa progression. Moreover, through gene silencing approaches we show that Id1 and Id3 primarily attenuates CDKN1A (p21) and CDKN1B (p27), respectively. We also demonstrate that silencing Id3 alone significantly attenuates proliferation of PCa cells as compared with Id1. We propose that increased Id1 and Id3 expression attenuates all three cyclin-dependent kinase inhibitors (CDKN2B, -1A, and -1B) resulting in a more aggressive PCa phenotype
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Hydrothermal venting on the flanks of Heard and McDonald islands, southern Indian Ocean
Lupton, J. E.; Arculus, R. J.; Coffin, M.; Bradney, A.; Baumberger, T.; Wilkinson, C.
2017-12-01
Heard Island and the nearby McDonald Islands are two sites of active volcanism associated with the so-called Kerguelen mantle plume or hot spot. In fact, it has been proposed that the Kerguelen hot spot is currently located beneath Heard Island. During its maiden maximum endurance voyage (IN2016_V01), the recently commissioned Australian R/V Investigator conducted a detailed bathymetric and water column survey of the waters around Heard Island and the McDonald Islands as well as other sites on the Kerguelen Plateau. Some 50 hydrographic profiles were completed using the CTD/rosette system equipped with trace metal sampling and a nephelometer for suspended particle concentrations. In addition to the hydrographic profiles, 244 bubble plumes were detected in the vicinity of the Heard and McDonald Islands using the ship's multibeam system. It is thought that the bubble plumes observed on sea knolls and other seafloor surrounding the McDonald Islands are likely hydrothermal in origin, while plumes northeast of Heard Island may be biogenic methane from cold seeps. At 29 of the hydrographic stations water samples for helium isotope measurements were drawn from the CTD rosette and hermetically sealed into copper tubing for subsequent shorebased mass spectrometer and gas chromatograph analysis. In this paper we report results for 3He/4He ratios and CO2 and CH4 concentrations in water samples collected with the CTD/rosette, and discuss how these results are correlated with suspended particle concentrations and temperature anomalies.
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'Acting like chameleons’: on the McDonaldization of private security
van Steden, R.; de Waard, J.
2013-01-01
Private security is a fragmented industry with tens of thousands of small- and medium-sized suppliers worldwide. However, with the arrival in the market of multinational brands such as Group 4 Securicor and Securitas, we are witnessing a McDonaldization of security commodities. This development
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Management závěrečného turnaje McDonalds cup 2015
Kafka, Dominik
2016-01-01
Title: Management of the McDonald's Cup 2015 final tournament Objectives: The main objective of this thesis is to provide a detailed analysis of the management of the McDonald's Cup 2015 final tournament known as the Festival of Football, to present its strengths, weaknesses, potential opportunities and threats and then, based on previous analyses, to create a list of suggestions and recommendations leading to the elimination of the weaknesses and threats and thus to development, increase of ...
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McDonald and Company Securities Library User Survey, 1996.
Wolfgram, Derek E.
The library of McDonald and Company Securities is important to the success of the business and its employees. This study assesses the needs and expectations of the library users, and analyzes how well the current library services are meeting those needs and expectations. A questionnaire was distributed to a large random sample of the firm's…
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Knot positioning during McDonald cervical cerclage, does it make a difference? A cohort study.
Atia, Hytham; Ellaithy, Mohamed; Altraigey, Ahmed; Ibrahim, Heba
2018-05-15
To study the effect of McDonald cerclage knot position on the different maternal and neonatal outcomes. This historical cohort study included women with singleton pregnancy who had a prophylactic McDonald cervical cerclage between 1 May 2010 and 31 September 2017. Maternal and neonatal outcome parameters were compared between the anterior and posterior knot cerclage procedures. The primary outcome measure was the rate of term birth. 550 Women had a prophylactic McDonald cervical cerclage, 306 with anterior knot (Group A) and 244 with posterior knot (Group B). There were no statistically significant differences regarding gestational age (GA) at delivery (36.3 ± 4.2 versus 35.8 ± 5.3 for groups A and B respectively), term birth rate, post-cerclage cervical length, symptomatic vaginitis, urinary tract infection, difficult cerclage removal and cervical lacerations. Similarly, there were no statistically significant differences as regards the studied neonatal outcomes including take home babies, neonatal intensive care admission, respiratory distress syndrome and neonatal sepsis. Survival analysis on GA at delivery demonstrated no statistically significant difference as regards the proportion of term deliveries in the anterior and posterior knot cerclage groups (log-rank test p-value = .478). Knot positioning during McDonald cervical cerclage, anteriorly or posteriorly, didn't significantly impact the studied maternal and neonatal outcomes.
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J. Crush and D.A. McDonald. (eds). 2002. Transnationalism and ...
African Journals Online (AJOL)
J. Crush and D.A. McDonald. (eds). 2002. Transnationalism and New African Immigration to South Africa. Cape Town. Southern African Migration Project and the Canadian Association of African Studies. IV + 188 pp. ISBN 0-88911-926-0.
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Radial Velocity Detection of Extra-Solar Planetary Systems
Cochran, William D.
2004-01-01
This NASA Origins Program grant supported four closely related research programs at The University of Texas at Austin: 1) The McDonald Observatory Planetary Search (MOPS) Program, using the McDonald Observatory 2.7m Harlan Smith telescope and its 2dcoude spectrometer, 2) A high-precision radial-velocity survey of Hyades dwarfs, using the Keck telescope and its HIRES spectrograph, 3) A program at McDonald Observatory to obtain spectra of the parent stars of planetary systems at R = 210,000, and 4) the start of high precision radial velocity surveys using the Hobby-Eberly Telescope. The most important results from NASA support of these research programs are described. A list of all papers published under support of this grant is included at the end.
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Now called RSA SecurID, SecurID is a mechanism developed by Security Dynamics that allows two-factor authentication for a user on a network resource. It works on the principle of the unique password mode, based on a shared secret. Every sixty seconds, the component generates a new six-digit token on the screen. The latter comes from the current time (internal clock) and the seed (SecurID private key that is available on the component, and is also from the SecurID server). During an authentication request, the SecurID server will check the entered token by performing exactly the same calculation as that performed by your component. The server knows the two information required for this calculation: the current time and the seed of your component. Access is allowed if the token calculated by the server matches the token you specified.
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A Note on McDonald's Generalization of Principal Components Analysis
Shine, Lester C., II
1972-01-01
It is shown that McDonald's generalization of Classical Principal Components Analysis to groups of variables maximally channels the totalvariance of the original variables through the groups of variables acting as groups. An equation is obtained for determining the vectors of correlations of the L2 components with the original variables.…
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Maximilien Brice
2002-01-01
Photos 01,02: Mr Pat McDonald, Director of "Key Business Technologies", Department of Trade and Industry, UK (third from left, front) in front of the ATLAS End-Cap Toroid vacuum vessel in the ATLAS assembly hall with, from left to right, Fred Wickens, Chris Jones, Peter Fletcher, Ray Browne, Neil Geddes, Jim Fleming, Anne Trefethen, Jim Wilson, Edwin Towndrow, Sharon Bonfield, Guy Rickett, Ken Smith, Peter Jenni. Photo 03: Mr Pat McDonald, Director of "Key Business Technologies", Department of Trade and Industry, UK (fifth from left) visiting ATLAS assembly hall with, from left to right, Jim Wilson, Peter Jenni, Ken Smith, Edwin Towndrow, Ray Brown, Chris Jones, Neil Geddes, Sharon Bonfield, Anne Trefethen, Jim Fleming, Fred Wickens. Photo 04: Mr Pat McDonald, Director of "Key Business Technologies", Department of Trade and Industry, UK (fourth from right) in front of the ATLAS Barrel Toroid coil casing in the ATLAS assembly hall with, from left to right, Peter Jenni, Jim Wilson, Guy Rickett, Anne Trefethen, ...
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MCDonalds mārketinga komunikācijas analīze : Latvija-Īrija
Kazakova, Nataļja
2010-01-01
Diplomdarba tēma; pētāmās problēmas apraksts: McDonalds pielietoto mārketinga komunikāciju analīze Latvijā un Īrijā; pētījuma veikšanas laikā daudzus uzņēmumus šajās valstīs (un īpaši Latvijā) skar ekonomiskās krīzes sekas, tāpēc ir nepieciešami aplūkot tādu uzņēmumu pieredzi, kas veiksmīgi darbojas starptautiskajā tirgū ilglaicīgi. Atslēgas vārdi: McDonalds, mārketinga komunikācijas, reklāma, preces virzīšana tirgū, e-mārketings, sabiedriskās attiecības, tiešā pārdošana, personiskā apkalp...
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Beneath the Golden Arches: The McDonald's Corporation [and] Teacher's Guide.
Brufke, Edward F.
This teacher developed case study which surveys the meteoric rise of the McDonald's Corporation and that of its chief promoter, Ray Kroc, is intended to help secondary students develop an understanding of economics and of the decision-making process. A teacher's guide containing questions for discussion and suggestions for class activities is…
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McJobs and Pieces of Flair: Linking McDonaldization to Alienating Work
Treiber, Linda Ann
2013-01-01
This article offers strategies for teaching about rationality, bureaucracy, and social change using George Ritzer's "The McDonaldization of Society" and its ideas about efficiency, predictability, calculability, and control. Student learning is facilitated using a series of strategies: making the familiar strange, explaining…
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The Rationalization of Everything? Using Ritzer's McDonaldization Thesis To Teach Weber.
Lippmann, Stephen; Aldrich, Howard
2003-01-01
Outlines a plan for helping undergraduate students appreciate Max Weber's theoretical achievements, teaching critical thinking about what constitutes 'the good life' in rationalized societies. Uses the book "The McDonaldization of Society" (George Ritzer) to encourage student interest in Weber's work. Describes field exercises and…
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McDonald Generalized Linear Failure Rate Distribution
Directory of Open Access Journals (Sweden)
Ibrahim Elbatal
2014-10-01
Full Text Available We introduce in this paper a new six-parameters generalized version of the generalized linear failure rate (GLFR distribution which is called McDonald Generalized Linear failure rate (McGLFR distribution. The new distribution is quite flexible and can be used effectively in modeling survival data and reliability problems. It can have a constant, decreasing, increasing, and upside down bathtub-and bathtub shaped failure rate function depending on its parameters. It includes some well-known lifetime distributions as special sub-models. Some structural properties of the new distribution are studied. Moreover we discuss maximum likelihood estimation of the unknown parameters of the new model.
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Figueroa, Reinaldo; Crowell, Rebecca; Martinez, Alvin; Morgan, Marielle; Wakefield, Dorothy
2018-04-30
To compare obstetrical outcomes on women undergoing a McDonald or Shirodkar cerclage and to estimate the impact of maternal body mass index (BMI) on these outcomes. We conducted a retrospective review of the medical records of all women with singleton pregnancies who underwent placement of a McDonald or Shirodkar cerclage at St. Francis Hospital from January 2008 to October 2013. The subjects were categorized based on BMI groups (normal: less than 25 kg/m 2 , overweight: 25-29 kg/m 2 , obese: 30 kg/m 2 or more). The primary outcome was gestational age at delivery. Statistical analyses included chi-square, Student's t-test, and multivariable regression analysis. Of 95 women, 47 (49.5%) received a Shirodkar, and 48 (50.5%) a McDonald cerclage. 16 women (16.8%) were categorized as normal weight, 35 (36.8%) as overweight, and 44 (46.3%) as obese. Gestational age at delivery differed significantly by group, decreasing with each categorical increase in BMI (normal: 39.0 ± 0.3 weeks; overweight: 36.6 ± 0.7 weeks; obese: 33.0 ± 1.1 weeks; p McDonald cerclage (36.7 ± 0.6 weeks versus 33.9 ± 1.0 weeks; p = .02). However, analysis showed a significant interaction between weight status and gestational age at delivery. Obese women had significantly longer pregnancies when they received a Shirodkar cerclage versus a McDonald cerclage (32.6 ± 1.0 weeks versus 28.8 ± 0.9 weeks; p McDonald: 32.9 ± 0.9 weeks; p = .63). Compared to obese women receiving a McDonald cerclage, obese women receiving a Shirodkar cerclage had significantly longer pregnancies. No significant differences in pregnancy duration were found in normal/overweight women regardless of cerclage technique. Pregnancy duration in obese women receiving a Shirodkar cerclage was similar to the pregnancy duration of normal/overweight women.
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The McDonald exponentiated gamma distribution and its statistical properties
Al-Babtain, Abdulhakim A; Merovci, Faton; Elbatal, Ibrahim
2015-01-01
Abstract In this paper, we propose a five-parameter lifetime model called the McDonald exponentiated gamma distribution to extend beta exponentiated gamma, Kumaraswamy exponentiated gamma and exponentiated gamma, among several other models. We provide a comprehensive mathematical treatment of this distribution. We derive the moment generating function and the rth moment. We discuss estimation of the parameters by maximum likelihood and provide the information matrix. AMS Subject Classificatio...
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Williams, Mitchel T; Tapos, Daniela O; Juhász, Csaba
2014-12-01
Pediatric-onset multiple sclerosis represents around 3-5% of all patients with multiple sclerosis. Both the 2005 and 2010 McDonald criteria for multiple sclerosis have been suggested for the possible use in pediatric-onset multiple sclerosis. Modifications incorporated into the 2010 criteria enabled the fulfillment of dissemination in time to be met with the initial magnetic resonance imaging. The present study was designed to compare the diagnostic sensitivity of these criteria at initial presentation, the time to fulfilling them, and secondary effects of ethnicity in pediatric-onset multiple sclerosis. Twenty-five children with clinically definite multiple sclerosis (mean age, 14.6 ± 3.1 years; 15 girls) from a single center between 2005 and 2012 were analyzed using both the 2005 and 2010 McDonald criteria based on initial clinical presentation and neuroimaging findings comparing diagnostic sensitivity, time interval to meet diagnosis, and ethnicity. Initial multiple sclerosis diagnosis rates applying the 2005 McDonald criteria were 32% compared with 92% for the 2010 criteria (P = 0.0003). The mean time after initial signs until the 2005 and 2010 McDonald criteria for multiple sclerosis were met was 5.0 vs 0.7 months, respectively (P = 0.001). Time to diagnosis using the 2010 criteria was shorter in black children than the European white (P = 0.005). The 2010 McDonald criteria are an appropriate tool for the timely diagnosis of pediatric multiple sclerosis, especially in black children, potentially allowing an earlier initiation of disease-modifying therapy. Copyright © 2014 Elsevier Inc. All rights reserved.
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Energy Technology Data Exchange (ETDEWEB)
Ritzer, George (Maryland, Univ Of - College Pa); Malone, Elizabeth L.(BATTELLE (PACIFIC NW LAB)); Ritzer, George
2001-07-30
McDonaldization and the exportation of the new means of consumption tend to support the view that in at least some sectors the world is growing more homogeneous than heterogeneous. Against those globalization theorists who tend to focus on the importance of the local and therefore on heterogeneity, the study of McDonaldization and the new means of consumption emphasizes transnational issues and uniformity throughout the world. Fast-food restaurants do adapt to local markets, but the basic procedures of operation and marketing remain the same across a wide range of international settings. This is true even of indigenous versions. The uniformity is exported by transnational corporations, with nation-states less and less able to control or restrict such exports.
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Energy Technology Data Exchange (ETDEWEB)
Ritzer, George; Malone, Elizabeth L.
2000-07-31
McDonaldization and the exportation of the new means of consumption tend to support the view that in at least some sectors the world is growing more homogeneous than heterogeneous. Against those globalization theorists who tend to focus on the importance of the local and therefore on heterogeneity, the study of McDonaldization and the new means of consumption emphasizes transnational issues and uniformity throughout the world. Fast-food restaurants do adapt to local markets, but the basic procedures of operation and marketing remain the same across a wide range of international settings. This is true even of indigenous versions. The uniformity is exported by transnational corporations, with nation-states less and less able to control or restrict such exports.
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Pengalaman Komunikasi Pelanggan Zalora.co.id (Studi Fenomenologi Pelanggan Zalora.co.id)
Aji, Widya Andhika; Pradekso, Tandiyo; Ulfa, Nurist Surayya
2013-01-01
1PENGALAMAN KOMUNIKASI PELANGGAN ZALORA.CO.ID(Studi Fenomenologi Pelanggan Zalora.co.id)Oleh:Widya Andhika AjiFakultas Ilmu Sosial dan Ilmu PolitikUniversitas Diponegoro SemarangABSTRAKPenelitian ini bertujuan untuk menganalisis pengalaman komunikasi danpemahaman penerimaan konsumen terkait pesan komunikasi pemasaran dalamberbelanja di Zalora.co.id. Dengan menggunakan sampel pada lima informandan metode wawancara, dapat ditarik kesimpulan: Pelanggan Zalora.co.idmemiliki pengalaman komunikasi ...
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Id-1 and Id-2 genes and products as markers of epithelial cancer
Desprez, Pierre-Yves [El Cerrito, CA; Campisi, Judith [Berkeley, CA
2008-09-30
A method for detection and prognosis of breast cancer and other types of cancer. The method comprises detecting expression, if any, for both an Id-1 and an Id-2 genes, or the ratio thereof, of gene products in samples of breast tissue obtained from a patient. When expressed, Id-1 gene is a prognostic indicator that breast cancer cells are invasive and metastatic, whereas Id-2 gene is a prognostic indicator that breast cancer cells are localized and noninvasive in the breast tissue.
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Where Were the Whistleblowers? The Case of Allan McDonald and Roger Boisjoly.
Stewart, Lea P.
Employees who "blow the whistle" on their company because they believe it is engaged in practices that are illegal, immoral, or harmful to the public, often face grave consequences for their actions, including demotion, harassment, forced resignation, or termination. The case of Allan McDonald and Roger Boisjoly, engineers who blew the…
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McDonald's zjednodušuje mezinárodní ekonomická srovnání
Czech Academy of Sciences Publication Activity Database
Jurajda, Štěpán; Dušek, Libor
-, č. 4 (2007), s. 12-13 ISSN 1210-9525 Institutional research plan: CEZ:AV0Z70850503 Keywords : wages * international comparison Subject RIV: AH - Economics http://abicko.avcr.cz/cs/2007/4/06/ mcdonalds -zjednodusuje-mezinarodni-ekonomicka-srovnani.html
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DEFF Research Database (Denmark)
Larsen, Line Sofie Lunde; Larsson, H B W; Frederiksen, Jette Lautrup Battistini
2010-01-01
The diagnosis of MS is based on the revised McDonald criteria and is multidisciplinary. Both clinical and paraclinical measures are included. High-field magnetic resonance imaging (MRI) is becoming increasingly available and it is therefore necessary to clarify possible advantages of high-field MRI...... multiple sclerosis. Further larger studies of patients with clinically isolated syndromes are needed to settle the question of a diagnostic consequence of high-field imaging in MS. We suggest that the next revision of the McDonald diagnostic criteria include a recommendation of field strength....
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[The dangers and drifts of health McDonaldization].
Cembrani, Fabio
2016-01-01
The author reflects on the healthcare crisis, starting from globalization and liquid-modern society, with its systemic contradictions. The health care system is influenced by McDonald's success and its philosophy: efficiency, productivity, cost reduction, procedural standardization and control. This article underlines the deficiencies and manipulations in the health care system. The profit-oriented economic model is successful due to lack of attention to product quality from the globalised and hyper-consumerist society. Italian legislation has regulated the standardization in healthcare procedure, aiming at cost reduction of defensive medicine. It has been underlined that it defines actions, nevertheless human activity is mainly realized through language, gesture and creation. A new anthropological model is proposed, based on commitment and distributive justice.
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Khomutov, Sergey Y.
2017-10-01
Continuous magnetic measurements at Geophysical Observatory "Paratunka" (PET) of IKIR FEB RAS are performed since 1967. In the new millennium analogue magnetometers were modernized to digital, the technologies of absolute observations were changed, the data processing was completely transferred to computers, and the status of INTERMAGNET observatory was obtained. Currently, the observatory uses the following magnetometers: (a) for absolute observations - DIflux LEMI-203 (theodolite 3T2KP) and Mag-01 (theodolite Wild-T1), Overhauser magnetometers POS-1 and GSM-19W; (b) for variation measurements - fluxgate magnetometers FGE-DTU, FRG-601 and MAGDAS (installed under international agreements of IKIR), vector magnetometers dIdD GSM-19FD and POS-4 with Overhauser sensors and coil systems, scalar magnetometer GSM-90 and induction magnetometer STELAB. During Spring-Autumn season dIdD also is installed at remote station "Karymshina" at distance of 15 km from Observatory. There is monitoring system for monitoring of conditions in which magnetic observations are performed, including the semi-professional weather stations Davis Vantage Pro2 and WS2000 and a network of digital temperature sensors DS19B20 located at various points in magnetic pavilions and outdoor. All measurements are synchronized with the UTC. The results of observations are collected by the IKIR data server from the recorders and loggers, including in real-time. Specialized software was developed (based on MATLAB and Octave packages), which allows automatic and semi-automatic processing of data, the comparison of the results from different magnetometers and presenting final data in formats, defined by international standards, including INTERMAGNET. Significant efforts of observatory staff are direct to archive (raw) magnetic data, a significant part of which has not been entirely processed, is not presented in international data centers and is still not available to the scientific community. Digital images of
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Directory of Open Access Journals (Sweden)
Khomutov Sergey Y.
2017-01-01
Full Text Available Continuous magnetic measurements at Geophysical Observatory “Paratunka” (PET of IKIR FEB RAS are performed since 1967. In the new millennium analogue magnetometers were modernized to digital, the technologies of absolute observations were changed, the data processing was completely transferred to computers, and the status of INTERMAGNET observatory was obtained. Currently, the observatory uses the following magnetometers: (a for absolute observations – DIflux LEMI-203 (theodolite 3T2KP and Mag-01 (theodolite Wild-T1, Overhauser magnetometers POS-1 and GSM-19W; (b for variation measurements – fluxgate magnetometers FGE-DTU, FRG-601 and MAGDAS (installed under international agreements of IKIR, vector magnetometers dIdD GSM-19FD and POS-4 with Overhauser sensors and coil systems, scalar magnetometer GSM-90 and induction magnetometer STELAB. During Spring-Autumn season dIdD also is installed at remote station “Karymshina” at distance of 15 km from Observatory. There is monitoring system for monitoring of conditions in which magnetic observations are performed, including the semi-professional weather stations Davis Vantage Pro2 and WS2000 and a network of digital temperature sensors DS19B20 located at various points in magnetic pavilions and outdoor. All measurements are synchronized with the UTC. The results of observations are collected by the IKIR data server from the recorders and loggers, including in real-time. Specialized software was developed (based on MATLAB and Octave packages, which allows automatic and semi-automatic processing of data, the comparison of the results from different magnetometers and presenting final data in formats, defined by international standards, including INTERMAGNET. Significant efforts of observatory staff are direct to archive (raw magnetic data, a significant part of which has not been entirely processed, is not presented in international data centers and is still not available to the scientific
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Bennink, T.; Vergouw, E.
1998-01-01
Leuk werken is - volgens Manager Human Resources Lydia van Dongen - een belangrijk aandachtspunt bij de hamburgergigant McDonald's. Daarvoor haalt het bedrijf alles voor uit de kast. Investeren in arbozorg loont. In dit artikel wordt verslag gedaan van een interview met Lydia van Dongen. Hierbij
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Photometric Detection of Extra-Solar Planets
Hatzes, Artie P.; Cochran, William D.
2004-01-01
This NASA Origins Program grant supported the TEMPEST Texas McDonald Photometric Extrasolar Search for Transits) program at McDonald Observatory, which searches for transits of extrasolar planets across the disks of their parent stars. The basic approach is to use a wide-field ground-based telescope (in our case the McDonald Observatory 0.76m telescope and it s Prime Focus Corrector) to search for transits of short period (1-15 day orbits) of close-in hot-Jupiter planets in orbit around a large sample of field stars. The next task is to search these data streams for possible transit events. We collected our first set of test data for this program using the 0.76 m PFC in the summer of 1998. From those data, we developed the optimal observing procedures, including tailoring the stellar density, exposure times, and filters to best-suit the instrument and project. In the summer of 1999, we obtained the first partial season of data on a dedicated field in the constellation Cygnus. These data were used to develop and refine the reduction and analysis procedures to produce high-precision photometry and search for transits in the resulting light curves. The TeMPEST project subsequently obtained three full seasons of data on six different fields using the McDonald Observatory 0.76m PFC.
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Lumley, R; Davenport, R; Williams, A
2015-03-01
The diagnostic criteria for multiple sclerosis have evolved over time and currently the 2010 McDonald criteria are the most widely accepted. These criteria allow the diagnosis of multiple sclerosis to be made at the clinically isolated syndrome stage provided certain criteria are met on a single magnetic resonance brain scan. Our hypothesis was that neurologists in Scotland did not use these criteria routinely. We sent a SurveyMonkey questionnaire to all Scottish neurologists (consultants and trainees) regarding the diagnosis of multiple sclerosis. Our questionnaire response rate was 65/99 (66%). Most Scottish neurologists were aware of the criteria and 31/58 (53%) felt that they were using these routinely. However, in a clinical vignette designed to test the application of these criteria, only 5/57 (9%) of neurologists appeared to use them. Scottish neurologists' use of the 2010 McDonald criteria for diagnosis of multiple sclerosis varies from practitioners' perception of their use of these criteria.
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Beam transport radiation shielding for branch lines 2-ID-B and 2-ID-C
International Nuclear Information System (INIS)
Feng, Y.P.; Lai, B.; McNulty, I.; Dejus, R.J.; Randall, K.J.; Yun, W.
1995-01-01
The x-ray radiation shielding requirements beyond the first optics enclosure have been considered for the beam transport of the 2-ID-B and 2-ID-C branch lines of Sector 2 (SRI-CAT) of the APS. The first three optical components (mirrors) of the 2-ID-B branch are contained within the shielded first optics enclosure. Calculations indicate that scattering of the primary synchrotron beam by beamline components outside the enclosure, such as apertures and monochromators, or by gas particles in case of vacuum failure is within safe limits for this branch. A standard 2.5-inch-diameter stainless steel pipe with 1/16-inch-thick walls provides adequate shielding to reduce the radiation dose equivalent rate to human tissue to below the maximum permissible limit of 0.25 mrem/hr. The 2-ID-C branch requires, between the first optics enclosure where only two mirrors are used and the housing for the third mirror, additional lead shielding (0.75 mm) and a minimum approach distance of 2.6 cm. A direct beam stop consisting of at least 4.5 mm of lead is also required immediately downstream of the third mirror for 2-ID-C. Finally, to stop the direct beam from escaping the experimental station, a beam stop consisting of at least 4-mm or 2.5-mm steel is required for the 2-ID-B or 2-ID-C branches, respectively. This final requirement can be met by the vacuum chambers used to house the experiments for both branch lines
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Gamage, Sujani Madhurika Kodagoda; Wijeweera, Indunil; Wijesinghe, Priyangi; Adikari, Sanjaya Bandara; Fink, Katharina; Sominanda, Herath Mudiyanselage Ajith
2018-05-31
The magnetic resonance imaging in multiple sclerosis (MAGNIMS) group recently proposed guidelines to replace the existing dissemination-in-space criteria in McDonald 2010 magnetic resonance imaging (MRI) criteria for diagnosing multiple sclerosis. There has been insufficient research regarding their applicability in Asians. Objective of this study was to determine the sensitivity, specificity, accuracy, positive predictive value (PPV), and negative predictive value (NPV) of McDonald 2010 and MAGNIMS 2016 MRI criteria with the aim of verifying their applicability in Sri Lankan patients. Patients with clinically isolated syndrome diagnosed by consultant neurologists were recruited from five major neurology centers. Baseline and follow-up MRI scans were performed within 3 months from the initial presentation and at one year after baseline MRI, respectively. McDonald 2010 and MAGNIMS 2016 MRI criteria were applied to all MRI scans. Patients were followed-up for 2 years to assess the conversion to clinically definite multiple sclerosis (CDMS). The sensitivity, specificity, accuracy, PPV, and NPV for predicting the conversion to CDMS were calculated. Forty-two of 66 patients converted to CDMS. Thirty-seven fulfilled the McDonald 2010 MRI criteria, and 33 converted to CDMS. MAGNIMS 2016 MRI criteria were fulfilled by 29, with 28 converting to CDMS. The sensitivity, specificity, accuracy, PPV, and NPV were 78%, 83%, 64%, 89%, and 69%, respectively, for the McDonald 2010 criteria, and 67%, 96%, 77%, 96%, and 62% for the MAGNIMS 2016 MRI criteria. MAGNIMS 2016 MRI criteria were superior to McDonald 2010 MRI criteria in specificity, accuracy, and PPV, but inferior in sensitivity and NPV. Copyright © 2018 Korean Neurological Association.
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A proposed HTTP service based IDS
Directory of Open Access Journals (Sweden)
Mohamed M. Abd-Eldayem
2014-03-01
Full Text Available The tremendous growth of the web-based applications has increased information security vulnerabilities over the Internet. Security administrators use Intrusion-Detection System (IDS to monitor network traffic and host activities to detect attacks against hosts and network resources. In this paper IDS based on Naïve Bayes classifier is analyzed. The main objective is to enhance IDS performance through preparing the training data set allowing to detect malicious connections that exploit the http service. Results of application are demonstrated and discussed. In the training phase of the proposed IDS, at first a feature selection technique based on Naïve Bayes classifier is used, this technique identifies the most important HTTP traffic features that can be used to detect HTTP attacks. In the testing and running phases proposed IDS classifies the network traffic based on the requested service, then based on the selected features Naïve Bayes classifier is used to analyze the HTTP service based traffic and identifies the HTTP normal connections and attacks. The performance of the IDS is measured through experiments using NSL-KDD data set. The results show that the detection rate of the IDS is about 99%, the false-positive rate is about 1%, and the false-negative rate is about 0.25%; therefore, proposed IDS holds the highest detection rate and the lowest false alarm compared with other leading IDS. In addition, the proposed IDS based on Naïve Bayes is used to classify network connections as a normal or attack. And it holds a high detection rate and a low false alarm.
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Private Observatories in South Africa
Rijsdijk, C.
2016-12-01
Descriptions of private observatories in South Africa, written by their owners. Positions, equipment descriptions and observing programmes are given. Included are: Klein Karoo Observatory (B. Monard), Cederberg Observatory (various), Centurion Planetary and Lunar Observatory (C. Foster), Le Marischel Observatory (L. Ferreira), Sterkastaaing Observatory (M. Streicher), Henley on Klip (B. Fraser), Archer Observatory (B. Dumas), Overbeek Observatory (A. Overbeek), Overberg Observatory (A. van Staden), St Cyprian's School Observatory, Fisherhaven Small Telescope Observatory (J. Retief), COSPAR 0433 (G. Roberts), COSPAR 0434 (I. Roberts), Weltevreden Karoo Observatory (D. Bullis), Winobs (M. Shafer)
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Tinjauan Desain Website Kemlu.Go.Id
Danu Widhyatmoko
2013-01-01
Review of kemlu.go.id website design is a research report on Kemlu.go.id website design. Kemlu.go.id website aims to be the information gateway of Ministry of Foreign Affairs, and also as guidelines of foreign politic policies of Republic of Indonesia. The review had been accomplished by using analytical method based on the "Nine Essential Principles for Good Web Design" developed by Collis Ta'eed (2007). At the end of the article, several recommendations in developing kemlu.go.id website are...
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Thais, Savannah Jennifer; The ATLAS collaboration
2018-01-01
Efficient and accurate electron identification is of critical importance to measuring many physics processes with leptons in the final state, including H->4l, dark vector boson searches, and various SUSY searches. This poster will describe the current status of the Likelihood driven Electron ID, highlighting the recent move from a MC driven ID to a data-driven ID. It will include the most recent identification efficiency and scale-factor measurements. Additionally, it will describe continued improvements for Run 2 electron ID, highlighting improvements in the low pt region and potential Machine Learning improvements.
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Tinjauan Desain Website Kemlu.Go.Id
Directory of Open Access Journals (Sweden)
Danu Widhyatmoko
2013-04-01
Full Text Available Review of kemlu.go.id website design is a research report on Kemlu.go.id website design. Kemlu.go.id website aims to be the information gateway of Ministry of Foreign Affairs, and also as guidelines of foreign politic policies of Republic of Indonesia. The review had been accomplished by using analytical method based on the "Nine Essential Principles for Good Web Design" developed by Collis Ta'eed (2007. At the end of the article, several recommendations in developing kemlu.go.id website are presented to create better appearance.
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Students Across Texas Celebrate Astronomy Day
Preston, S.; Wetzel, M.; Hemenway, M. K.
2010-08-01
Over the past three years, McDonald Observatory has offered special Astronomy Day videoconference programs to students across Texas—the second largest state in the U.S. (Only Alaska is larger). Videoconferencing allows many students and teachers access to our Observatory, which is remotely located 180 miles (290 kilometers) from any major city. McDonald Observatory partners with Connect2Texas to advertise the Astronomy Day event. Connect2Texas provides the electronic bridge between schools and the Observatory. They also provide an online evaluation for teachers to complete. In 2009 the Astronomy Day videoconference celebrated the International Year of Astronomy and the historic observations made by Galileo Galilei. During the videoconference, the classes explore the Moon or Venus by making real-time telescopic observations. Students also receive an introduction to the Observatory, an opportunity to perform an activity relating to Galileo's observations, and an interview with an astronomer. A website provides teachers pre-and post-video conference materials, instructions, and a certificate of completion that can be customized for each student. The website also lists content alignment with state science education standards.
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Cultural Differences Applied in International Marketing : Cases Of McDonalds and Red Bull
Abdulkerimova, Assiyat
2017-01-01
The main purpose of this thesis is to demonstrate how culture and cultural differences influence on the international marketing. Also, it demonstrates how international companies deal with cross-cultural issues and problems. First, the importance of culture and two models of cultural dimensions like Hofstede and Trompenaars will be analyzed and discussed. Second, the marketing activities of two international corporations- McDonald's and Red Bull will be discussed and analyzed. The research wi...
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DEFF Research Database (Denmark)
Jensen, Tenna; Jespersen, Astrid Pernille; Grønnow, Liv Cæcilie
2015-01-01
Idékataloget er en selvstændig publikation hørende til projekt Appetit på maden. Idékataloget er udviklet til brug i Københavns Kommune.......Idékataloget er en selvstændig publikation hørende til projekt Appetit på maden. Idékataloget er udviklet til brug i Københavns Kommune....
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The Russian-Ukrainian Observatories Network for the European Astronomical Observatory Route Project
Andrievsky, S. M.; Bondar, N. I.; Karetnikov, V. G.; Kazantseva, L. V.; Nefedyev, Y. A.; Pinigin, G. I.; Pozhalova, Zh. A.; Rostopchina-Shakhovskay, A. N.; Stepanov, A. V.; Tolbin, S. V.
2011-09-01
In 2004,the Center of UNESCO World Heritage has announced a new initiative "Astronomy & World Heritage" directed for search and preserving of objects,referred to astronomy,its history in a global value,historical and cultural properties. There were defined a strategy of thematic programme "Initiative" and general criteria for selecting of ancient astronomical objects and observatories. In particular, properties that are situated or have significance in relation to celestial objects or astronomical events; representations of sky and/or celestial bodies and astronomical events; observatories and instruments; properties closely connected with the history of astronomy. In 2005-2006,in accordance with the program "Initiative", information about outstanding properties connected with astronomy have been collected.In Ukraine such work was organized by astronomical expert group in Nikolaev Astronomical Observatory. In 2007, Nikolaev observatory was included to the Tentative List of UNESCO under # 5116. Later, in 2008, the network of four astronomical observatories of Ukraine in Kiev,Crimea, Nikolaev and Odessa,considering their high authenticities and integrities,was included to the Tentative List of UNESCO under # 5267 "Astronomical Observatories of Ukraine". In 2008-2009, a new project "Thematic Study" was opened as a successor of "Initiative". It includes all fields of astronomical heritage from earlier prehistory to the Space astronomy (14 themes in total). We present the Ukraine-Russian Observatories network for the "European astronomical observatory Route project". From Russia two observatories are presented: Kazan Observatory and Pulkovo Observatory in the theme "Astronomy from the Renaissance to the mid-twentieth century".The description of astronomical observatories of Ukraine is given in accordance with the project "Thematic study"; the theme "Astronomy from the Renaissance to the mid-twentieth century" - astronomical observatories in Kiev,Nikolaev and Odessa; the
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DEFF Research Database (Denmark)
Filippi, Massimo; Preziosa, Paolo; Meani, Alessandro
2018-01-01
of the distinction between symptomatic and asymptomatic lesions was suggested. We compared the performance of the 2010 McDonald and 2016 MAGNIMS criteria for multiple sclerosis diagnosis in a large multicentre cohort of patients with CIS to provide evidence to guide revisions of multiple sclerosis diagnostic......, 2017, 571 patients with CIS were screened, of whom 368 met all study inclusion criteria. At the last evaluation (median 50·0 months [IQR 27·0-78·4]), 189 (51%) of 368 patients developed clinically definite multiple sclerosis. At 36 months, the two DIS criteria showed high sensitivity (2010 McDonald 0......·32-0·50], and similar AUC (0·63 [0·57-0·68]). Inclusion of optic nerve evaluation resulted in similar sensitivity (0·92 [0·87-0·96]), and slightly lower specificity (0·26 [0·18-0·34]) and AUC (0·59 [0·55-0·64]). AUC values were also similar for DIT (2010 McDonald 0·61 [0·55-0·67] and 2016 MAGNIMS 0·61 [0...
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A Moderate Redshift Supernova Search Program
Adams, M. T.; Wheeler, J. C.; Ward, M.; Wren, W. R.; Schmidt, B. P.
1995-12-01
We report on a recently initiated supernova (SN) search program using the McDonald Observatory 0.76m telescope and Prime Focus Camera (PFC). This SN search program takes advantage of the PFC's 42.6 x 42.6 arcmin FOV to survey moderate redshift Abell clusters in single Kron-Cousins R-band images. Our scientific goal is to discover and provide quality BVRI photometric follow-up, to R \\ +21, for a significant SNe sample at 0.03 group (Perlmutter et al 1995, ApJ, 440, L41), and the High Redshift SN Search Team (Schmidt et al 1995, Aiguiblava NATO ASI Proceedings). The McDonald SN search program includes a sample of the Abell clusters used by Lauer and Postman (1994, ApJ, 425, 418) to analyze Local Group motion. SNe discovered in these clusters contribute to the resolution of the Local Group motion controversy. We present an overview of the McDonald Observatory supernova search program, and discuss recent results.
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Watson, S. J.; Spain, E. A.; Coffin, M. F.; Whittaker, J. M.; Fox, J. M.; Bowie, A. R.
2016-12-01
Heard and McDonald islands (HIMI) are two active volcanic edifices on the Central Kerguelen Plateau. Scientists aboard the Heard Earth-Ocean-Biosphere Interactions voyage in early 2016 explored how this volcanic activity manifests itself near HIMI. Using Simrad EK60 split-beam echo sounder and deep tow camera data from RV Investigator, we recorded the distribution of seafloor emissions, providing the first direct evidence of seabed discharge around HIMI, mapping >244 acoustic plume signals. Northeast of Heard, three distinct plume clusters are associated with bubbles (towed camera) and the largest directly overlies a sub-seafloor opaque zone (sub-bottom profiler) with >140 zones observed within 6.5 km. Large temperature anomalies did not characterize any of the acoustic plumes where temperature data were recorded. We therefore suggest that these plumes are cold methane seeps. Acoustic properties - mean volume backscattering and target strength - and morphology - height, width, depth to surface - of plumes around McDonald resembled those northeast of Heard, also suggesting gas bubbles. We observed no bubbles on extremely limited towed camera data around McDonald; however, visibility was poor. The acoustic response of the plumes at different frequencies (120 kHz vs. 18 kHz), a technique used to classify water column scatterers, differed between HIMI, suggestiing dissimilar target size (bubble radii) distributions. Environmental context and temporal characteristics of the plumes differed between HIMI. Heard plumes were concentrated on flat, sediment rich plains, whereas around McDonald plumes emanated from sea knolls and mounds with hard volcanic seafloor. The Heard plumes were consistent temporally, while the McDonald plumes varied temporally possibly related to tides or subsurface processes. Our data and analyses suggest that HIMI acoustic plumes were likely caused by gas bubbles; however, the bubbles may originate from two or more distinct processes.
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Confirmation of AT 2017eaw, a Probable Supernova in NGC 6946
Dong, Subo; Stanek, K. Z.
2017-05-01
Supernova candidate AT 2017eaw was discovered by Patrick Wiggins at 12.8 mag on 2017-05-14 05:42:43. We confirmed AT 2017eaw with images taken by Las Cumbres Observatory (LCO)'s 1m telescope at McDonald observatory on UT 2017-05-14 10:30:31.
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Observatories and Telescopes of Modern Times
Leverington, David
2016-11-01
Preface; Part I. Optical Observatories: 1. Palomar Mountain Observatory; 2. The United States Optical Observatory; 3. From the Next Generation Telescope to Gemini and SOAR; 4. Competing primary mirror designs; 5. Active optics, adaptive optics and other technical innovations; 6. European Northern Observatory and Calar Alto; 7. European Southern Observatory; 8. Mauna Kea Observatory; 9. Australian optical observatories; 10. Mount Hopkins' Whipple Observatory and the MMT; 11. Apache Point Observatory; 12. Carnegie Southern Observatory (Las Campanas); 13. Mount Graham International Optical Observatory; 14. Modern optical interferometers; 15. Solar observatories; Part II. Radio Observatories: 16. Australian radio observatories; 17. Cambridge Mullard Radio Observatory; 18. Jodrell Bank; 19. Early radio observatories away from the Australian-British axis; 20. The American National Radio Astronomy Observatory; 21. Owens Valley and Mauna Kea; 22. Further North and Central American observatories; 23. Further European and Asian radio observatories; 24. ALMA and the South Pole; Name index; Optical observatory and telescope index; Radio observatory and telescope index; General index.
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Uzņēmuma McDonalds konkurētspējas novērtēšanas un tās uzlabošanas iespējas
Artemjeva, Anžela
2012-01-01
Bakalaura darba tēma – „Uzņēmuma McDonalds konkurētspējas novērtēšana un tās uzlabošanas iespējas”. Bakalaura darba mērķis-pamatojoties uz teorētiskām atziņām par konkurenci un konkurētspēju, izpētīt SIA McDonalds konkurētspēju tirgū un tās pilnveidošanas iespējas balstoties uz Latvijas, Lietuvas un Igaunijas investīciju nozares analīzes datu rezultātiem, izdarīt secinājumus un sniegt priekšlikumus SIA McDonalds konkurētspējas uzlabošanai. Bakalaura darba izstrādes gaitā autore ir izstr...
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Taurus Hill Observatory Scientific Observations for Pulkova Observatory during the 2016-2017 Season
Hentunen, V.-P.; Haukka, H.; Heikkinen, E.; Salmi, T.; Juutilainen, J.
2017-09-01
Taurus Hill Observatory (THO), observatory code A95, is an amateur observatory located in Varkaus, Finland. The observatory is maintained by the local astronomical association Warkauden Kassiopeia. THO research team has observed and measured various stellar objects and phenomena. Observatory has mainly focused on exoplanet light curve measurements, observing the gamma rays burst, supernova discoveries and monitoring. We also do long term monitoring projects.
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Facts about Infectious Diseases (ID)
... an ID Specialist? Facts about ID Pocketcard Infectious diseases are caused by microscopic organisms that penetrate the body’s natural ... from diseases such as AIDS or treatment of diseases such as cancer, may allow ... of contaminated food or water, bites from vectors such as ticks or mosquitoes ...
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One ID Card for the Entire Campus.
Ridenour, David P.; Ferguson, Linda M.
1986-01-01
The implementation by Indiana State University of a machine-readable photo ID system for their food services prompted an investigation into the available alternatives and requirements for a more efficient all-University ID card system. The new ID system is described. (AUTHOR/MLW)
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Desprez, Pierre-Yves; Campisi, Judith
2014-09-30
A method for treatment and amelioration of breast, cervical, ovarian, endometrial, squamous cells, prostate cancer and melanoma in a patient comprising targeting Id-1 or Id-2 gene expression with a delivery vehicle comprising a product which modulates Id-1 or Id-2 expression.
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Huss, André M; Halbgebauer, Steffen; Öckl, Patrick; Trebst, Corinna; Spreer, Annette; Borisow, Nadja; Harrer, Andrea; Brecht, Isabel; Balint, Bettina; Stich, Oliver; Schlegel, Sabine; Retzlaff, Nele; Winkelmann, Alexander; Roesler, Romy; Lauda, Florian; Yildiz, Özlem; Voß, Elke; Muche, Rainer; Rauer, Sebastian; Bergh, Florian Then; Otto, Markus; Paul, Friedemann; Wildemann, Brigitte; Kraus, Jörg; Ruprecht, Klemens; Stangel, Martin; Buttmann, Mathias; Zettl, Uwe K; Tumani, Hayrettin
2016-12-01
The majority of patients presenting with a first clinical symptom suggestive of multiple sclerosis (MS) do not fulfill the MRI criteria for dissemination in space and time according to the 2010 revision of the McDonald diagnostic criteria for MS and are thus classified as clinically isolated syndrome (CIS). To re-evaluate the utility of cerebrospinal fluid (CSF) analysis in the context of the revised McDonald criteria from 2010, we conducted a retrospective multicenter study aimed at determining the prevalence and predictive value of oligoclonal IgG bands (OCBs) in patients with CIS. Patients were recruited from ten specialized MS centers in Germany and Austria. We collected data from 406 patients; at disease onset, 44/406 (11 %) fulfilled the McDonald 2010 criteria for MS. Intrathecal IgG OCBs were detected in 310/362 (86 %) of CIS patients. Those patients were twice as likely to convert to MS according to McDonald 2010 criteria as OCB-negative individuals (hazard ratio = 2.1, p = 0.0014) and in a shorter time period of 25 months (95 % CI 21-34) compared to 47 months in OCB-negative individuals (95 % CI 36-85). In patients without brain lesions at first attack and presence of intrathecal OCBs (30/44), conversion rate to MS was 60 % (18/30), whereas it was only 21 % (3/14) in those without OCBs. Our data confirm that in patients with CIS the risk of conversion to MS substantially increases if OCBs are present at onset. CSF analysis definitely helps to evaluate the prognosis in patients who do not have MS according to the revised McDonald criteria.
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Babakhanyan, Anna; Leke, Rose G. F.; Salanti, Ali; Bobbili, Naveen; Gwanmesia, Philomina; Leke, Robert J. I.; Quakyi, Isabella A.; Chen, John J.; Taylor, Diane Wallace
2014-01-01
In pregnant women, Plasmodium falciparum-infected erythrocytes expressing the VAR2CSA antigen bind to chondroitin sulfate A in the placenta causing placental malaria. The binding site of VAR2CSA is present in the ID1-ID2a region. This study sought to determine if pregnant Cameroonian women naturally acquire antibodies to ID1-ID2a and if antibodies to ID1-ID2a correlate with absence of placental malaria at delivery. Antibody levels to full-length VAR2CSA and ID1-ID2a were measured in plasma samples from 745 pregnant Cameroonian women, 144 Cameroonian men, and 66 US subjects. IgM levels and IgG avidity to ID1-ID2a were also determined. As expected, antibodies to ID1-ID2a were absent in US controls. Although pregnant Cameroonian women developed increasing levels of antibodies to full-length VAR2CSA during pregnancy, no increase in either IgM or IgG to ID1-ID2a was observed. Surprisingly, no differences in antibody levels to ID1-ID2a were detected between Cameroonian men and pregnant women. For example, in rural settings only 8–9% of males had antibodies to full-length VAR2CSA, but 90–96% had antibodies to ID1-ID2a. In addition, no significant difference in the avidity of IgG to ID1-ID2a was found between pregnant women and Cameroonian men, and no correlation between antibody levels at delivery and absence of placental malaria was found. Thus, the response to ID1-ID2a was not pregnancy specific, but predominantly against cross-reactivity epitopes, which may have been induced by other PfEMP1 antigens, malarial antigens, or microbes. Currently, ID1-ID2a is a leading vaccine candidate, since it binds to the CSA with the same affinity as the full-length molecule and elicits binding-inhibitory antibodies in animals. Further studies are needed to determine if the presence of naturally acquired cross-reactive antibodies in women living in malaria endemic countries will alter the response to ID1-ID2a following vaccination with ID1-ID2a. PMID:24505415
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Directory of Open Access Journals (Sweden)
Anna Babakhanyan
Full Text Available In pregnant women, Plasmodium falciparum-infected erythrocytes expressing the VAR2CSA antigen bind to chondroitin sulfate A in the placenta causing placental malaria. The binding site of VAR2CSA is present in the ID1-ID2a region. This study sought to determine if pregnant Cameroonian women naturally acquire antibodies to ID1-ID2a and if antibodies to ID1-ID2a correlate with absence of placental malaria at delivery. Antibody levels to full-length VAR2CSA and ID1-ID2a were measured in plasma samples from 745 pregnant Cameroonian women, 144 Cameroonian men, and 66 US subjects. IgM levels and IgG avidity to ID1-ID2a were also determined. As expected, antibodies to ID1-ID2a were absent in US controls. Although pregnant Cameroonian women developed increasing levels of antibodies to full-length VAR2CSA during pregnancy, no increase in either IgM or IgG to ID1-ID2a was observed. Surprisingly, no differences in antibody levels to ID1-ID2a were detected between Cameroonian men and pregnant women. For example, in rural settings only 8-9% of males had antibodies to full-length VAR2CSA, but 90-96% had antibodies to ID1-ID2a. In addition, no significant difference in the avidity of IgG to ID1-ID2a was found between pregnant women and Cameroonian men, and no correlation between antibody levels at delivery and absence of placental malaria was found. Thus, the response to ID1-ID2a was not pregnancy specific, but predominantly against cross-reactivity epitopes, which may have been induced by other PfEMP1 antigens, malarial antigens, or microbes. Currently, ID1-ID2a is a leading vaccine candidate, since it binds to the CSA with the same affinity as the full-length molecule and elicits binding-inhibitory antibodies in animals. Further studies are needed to determine if the presence of naturally acquired cross-reactive antibodies in women living in malaria endemic countries will alter the response to ID1-ID2a following vaccination with ID1-ID2a.
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Evaluation of ID-PaGIA syphilis antibody test.
Naaber, Paul; Makoid, Ene; Aus, Anneli; Loivukene, Krista; Poder, Airi
2009-01-01
Laboratory diagnosis of syphilis is usually accomplished by serology. There are currently a large number of different commercial treponemal tests available that vary in format, sensitivity and specificity. To evaluate the ID-PaGIA Syphilis Antibody Test as an alternative to other specific treponemal tests for primary screening or confirmation of diagnosis. Serum samples from healthy adults (n = 100) were used for detection of specificity of ID-PaGIA. To evaluate sensitivity of ID-PaGIA serum samples (n = 101) from patients with confirmed or suspected syphilis were tested for syphilis antibodies with FTA-Abs IgM, ID-PaGIA, ELISA IgM and TPHA tests. No false-positive results were found with ID-PaGIA. Sensitivity of various treponemal tests was the following: FTA-Abs IgM: 95.5%, ID-PaGIA and ELISA IgM: 94%, and TPHA 75%. The positive and negative predictive values of ID-PaGIA were 100 and 89.5%, respectively. Compared with other treponemal tests ID-PaGIA has excellent sensitivity and specificity.
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Reliability and validity of the McDonald Play Inventory.
McDonald, Ann E; Vigen, Cheryl
2012-01-01
This study examined the ability of a two-part self-report instrument, the McDonald Play Inventory, to reliably and validly measure the play activities and play styles of 7- to 11-yr-old children and to discriminate between the play of neurotypical children and children with known learning and developmental disabilities. A total of 124 children ages 7-11 recruited from a sample of convenience and a subsample of 17 parents participated in this study. Reliability estimates yielded moderate correlations for internal consistency, total test intercorrelations, and test-retest reliability. Validity estimates were established for content and construct validity. The results suggest that a self-report instrument yields reliable and valid measures of a child's perceived play performance and discriminates between the play of children with and without disabilities. Copyright © 2012 by the American Occupational Therapy Association, Inc.
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Assessing the health impact of transnational corporations: a case study on McDonald?s Australia
Anaf, Julia; Baum, Frances E.; Fisher, Matt; Harris, Elizabeth; Friel, Sharon
2017-01-01
Background The practices of transnational corporations affect population health through production methods, shaping social determinants of health, or influencing the regulatory structures governing their activities. There has been limited research on community exposures to TNC policies and practices. Our pilot research used McDonald?s Australia to test methods for assessing the health impacts of one TNC within Australia. Methods We adapted existing Health Impact Assessment methods to assess M...
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The Observatory as Laboratory: Spectral Analysis at Mount Wilson Observatory
Brashear, Ronald
2018-01-01
This paper will discuss the seminal changes in astronomical research practices made at the Mount Wilson Observatory in the early twentieth century by George Ellery Hale and his staff. Hale’s desire to set the agenda for solar and stellar astronomical research is often described in terms of his new telescopes, primarily the solar tower observatories and the 60- and 100-inch telescopes on Mount Wilson. This paper will focus more on the ancillary but no less critical parts of Hale’s research mission: the establishment of associated “physical” laboratories as part of the observatory complex where observational spectral data could be quickly compared with spectra obtained using specialized laboratory equipment. Hale built a spectroscopic laboratory on the mountain and a more elaborate physical laboratory in Pasadena and staffed it with highly trained physicists, not classically trained astronomers. The success of Hale’s vision for an astronomical observatory quickly made the Carnegie Institution’s Mount Wilson Observatory one of the most important astrophysical research centers in the world.
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Haukka, H.; Hentunen, V.-P.; Nissinen, M.; Salmi, T.; Aartolahti, H.; Juutilainen, J.; Vilokki, H.
2013-09-01
Taurus Hill Observatory (THO), observatory code A95, is an amateur observatory located in Varkaus, Finland. The observatory is maintained by the local astronomical association of Warkauden Kassiopeia [8]. THO research team has observed and measured various stellar objects and phenomena. Observatory has mainly focuse d on asteroid [1] and exoplanet light curve measurements, observing the gamma rays burst, supernova discoveries and monitoring [2]. We also do long term monitoring projects [3]. THO research team has presented its research work on previous EPSC meetings ([4], [5],[6], [7]) and got very supportive reactions from the European planetary science community. The results and publications that pro-amateur based observatories, like THO, have contributed, clearly demonstrates that pro-amateurs area significant resource for the professional astronomers now and even more in the future.
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Directory of Open Access Journals (Sweden)
Isleide Arruda Fontenelle
2002-06-01
Full Text Available O palhaço Ronald McDonald -- uma das imagens de marca da Corporação McDonald's -- é tomado como paradigma para pensarmos as relações entre mercado, mídia e entretenimento, as quais tem uma ligação direta com o que estamos conceituando como "socialidade midiática". Enquanto uma metáfora ideal de uma propaganda que parece não querer mais fazer sentido, a história do palhaço nos permite desvendar os sentidos contidos em duas das principais práticas do marketing moderno, a propaganda e a publicidade, revelando-nos como, entre o nonsense da propaganda contemporânea e uma publicidade que fundiu realidade e ilusão, há uma relação visceral entre mídia e publicidade, que estabelece uma nova forma de comunicação, na qual o sujeito torna-se apenas um meio para fins que ele sabe quais são, mas, paradoxalmente, age como se não soubesse. Tal paradoxo é revelador de uma forma de subjetividade profundamente marcada pela mídia enquanto agente socializador, na medida em que a atuação da mídia como mediador da socialidade contemporânea acabou por alterar o nosso universo perceptivo, saturando o nosso imaginário de uma forma radicalmente nova. Some-se a isso o fato de que a "socialidade midiática" implica uma nova forma de representação do sujeito no registro do "espetáculo", no sentido de que "estar na imagem é existir". Desnecessário dizer o quanto essas questões precisam ser contempladas pelos estudos contemporâneos sobre os processos de socialização e o quanto são desafiadoras para aqueles que atuam no universo da educação.The clown Ronald McDonald -- one of the trademarks of the McDonald's Corporation -- is taken as a paradigm to reflect upon the relations between market, media, and entertainment, which have a direct link with what we define as "mediatic sociality". As an ideal metaphor of an advertising that no longer seems to attempt to make sense, the story of the clown allows us to unveil the meanings contained
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The Carl Sagan solar and stellar observatories as remote observatories
Saucedo-Morales, J.; Loera-Gonzalez, P.
In this work we summarize recent efforts made by the University of Sonora, with the goal of expanding the capability for remote operation of the Carl Sagan Solar and Stellar Observatories, as well as the first steps that have been taken in order to achieve autonomous robotic operation in the near future. The solar observatory was established in 2007 on the university campus by our late colleague A. Sánchez-Ibarra. It consists of four solar telescopes mounted on a single equatorial mount. On the other hand, the stellar observatory, which saw the first light on 16 February 2010, is located 21 km away from Hermosillo, Sonora at the site of the School of Agriculture of the University of Sonora. Both observatories can now be remotely controlled, and to some extent are able to operate autonomously. In this paper we discuss how this has been accomplished in terms of the use of software as well as the instruments under control. We also briefly discuss the main scientific and educational objectives, the future plans to improve the control software and to construct an autonomous observatory on a mountain site, as well as the opportunities for collaborations.
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VizieR Online Data Catalog: Elemental abundances of solar sibling candidates (Ramirez+, 2014)
Ramirez, I.; Bajkova, A. T.; Bobylev, V. V.; Roederer, I. U.; Lambert, D. L.; Endl, M.; Cochran, W. D.; MacQueen, P. J.; Wittenmyer, R. A.
2017-06-01
We used the Tull coude spectrograph on the 2.7 m Harlan J. Smith Telescope at McDonald Observatory (Tull et al. 1995PASP..107..251T) to observe most of our targets (23). All but three of them were observed in 2012 December; the others were observed in 2013 March. The rest of our targets (seven) have too-low declinations to be observed from McDonald Observatory. Instead, they were observed using the Magellan Inamori Kyocera Echelle (MIKE) spectrograph on the 6.5 m Telescope at Las Campanas Observatory (Bernstein et al. 2003SPIE.4841.1694B) in 2013 April. Slit sizes were chosen so that the spectral resolution of the data is about 60000 in the visible part of the spectrum. We targeted a S/N per pixel of at least 200 at 6000 Å. Only one of our targets (HD 46100) has a significantly lower S/N spectrum. (2 data files).
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Kloos, W E; George, C G
1991-01-01
The accuracies of the MicroScan Pos ID and Rapid Pos ID panel systems (Baxter Diagnostic Inc., MicroScan Division, West Sacramento, Calif.) were compared with each other and with the accuracies of conventional methods for the identification of 25 Staphylococcus species and 4 subspecies. Conventional methods included those used in the original descriptions of species and subspecies and DNA-DNA hybridization. The Pos ID panel uses a battery of 18 tests, and the Rapid Pos ID panel uses a battery of 42 tests for the identification of Staphylococcus species. The Pos ID panel has modified conventional and chromogenic tests that can be read after 15 to 48 h of incubation; the Rapid Pos ID panel has tests that use fluorogenic substrates or fluorometric indicators, and test results can be read after 2 h of incubation in the autoSCAN-W/A. Results indicated that both MicroScan systems had a high degree of congruence (greater than or equal to 90%) with conventional methods for the species S. capitis, S. aureus, S. auricularis, S. saprophyticus, S. cohnii, S. arlettae, S. carnosus, S. lentus, and S. sciuri and, in particular, the subspecies S. capitis subsp. capitis and S. cohnii subsp. cohnii. The Rapid Pos ID panel system also had greater than or equal to 90% congruence with conventional methods for S. epidermidis, S. caprae, S. warneri subsp. 2, S. xylosus, S. kloosii, and S. caseolyticus. For both MicroScan systems, congruence with conventional methods was 80 to 90% for S. haemolyticus subsp. 1, S. equorum, S. intermedius, and S. hyicus; and in addition, with the Rapid Pos ID panel system congruence was 80 to 89% for S. capitis subsp. ureolyticus, S. warneri subsp. 1, S. hominis, S. cohnii subsp. urealyticum, and S. simulans. The MicroScan systems identified a lower percentage (50 to 75%) of strains of S. lugdunensis, S. gallinarum, S. schleiferi, and S. chromogenes, although the addition of specific tests to the systems might increase the accuracy of identification
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Picard, K.; Watson, S. J.; Fox, J. M.; Post, A.; Whittaker, J. M.; Lucieer, V.; Carey, R.; Coffin, M. F.; Hodgson, D.; Hogan, K.; Graham, A. G. C.
2017-12-01
Unravelling the glacial history of Sub-Antarctic islands can provide clues to past climate and Antarctic ice sheet stability. The glacial history of many sub-Antarctic islands is poorly understood, including the Heard and McDonald Islands (HIMI) located on the Kerguelen Plateau in the southern Indian Ocean. The geomorphologic development of HIMI has involved a combination of construction via hotspot volcanism and mechanical erosion caused by waves, weather, and glaciers. Today, the 2.5 km2 McDonald Islands are not glacierised; in contrast, the 368 km2 Heard Island has 12 major glaciers, some extending from the summit of 2813 m to sea level. Historical accounts from Heard Island suggest that the glaciers were more extensive in the 1850s to 1870s, and have retreated at least 12% (33.89 km2) since 1997. However, surrounding bathymetry suggests a much more extensive previous glaciation of the HIMI region that encompassed 9,585 km2, likely dating back at least to the Last Glacial Maximum (LGM) ca. 26.5 -19 ka. We present analyses of multibeam bathymetry and backscatter data, acquired aboard RV Investigator in early 2016, that support the previous existence of an extensive icecap. These data reveal widespread ice-marginal and subglacial features including moraines, over-deepened troughs, drumlins and crag-and-tails. Glacial landforms suggest paleo-ice flow directions and a glacial extent that are consistent with previously documented broad scale morphological features. We identify >660 iceberg keel scours in water depths ranging from 150 - 530 m. The orientations of the iceberg keel scours reflect the predominantly east-flowing Antarctic Circumpolar Current and westerly winds in the region. 40Ar/39Ar dating of volcanic rocks from submarine volcanoes around McDonald Islands suggests that volcanism and glaciation coincided. The flat-topped morphology of these volcanoes may result from lava-ice interaction or erosion by glaciers post eruption during a time of extensive ice
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Commissioning of the IDS Neutron Detector and $\\beta$-decay fast-timing studies at IDS
Piersa, Monika
2016-01-01
The following report describes my scientific activities performed during the Summer Student Programme at ISOLDE. The main part of my project was focused on commissioning the neutron detector dedicated to nuclear decay studies at ISOLDE Decay Station (IDS). I have participated in all the steps needed to make it operational for the IS609 experiment. In the testing phase, we obtained expected detector response and calibrations confirmed its successful commissioning. The detector was mounted in the desired geometry at IDS and used in measurements of the beta-delayed neutron emission of $^8$He. After completing aforementioned part of my project, I became familiar with the fast-timing method. This technique was applied at IDS in the IS610 experiment performed in June 2016 to explore the structure of neutron-rich $^{130-134}$Sn nuclei. Since the main part of my PhD studies will be the analysis of data collected in this experiment, the second part of my project was dedicated to acquiring knowledge about technical de...
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Astronomical publications of Melbourne Observatory
Andropoulos, Jenny Ioanna
2014-05-01
During the second half of the 19th century and the first half of the 20th century, four well-equipped government observatories were maintained in Australia - in Melbourne, Sydney, Adelaide and Perth. These institutions conducted astronomical observations, often in the course of providing a local time service, and they also collected and collated meteorological data. As well, some of these observatories were involved at times in geodetic surveying, geomagnetic recording, gravity measurements, seismology, tide recording and physical standards, so the term "observatory" was being used in a rather broad sense! Despite the international renown that once applied to Williamstown and Melbourne Observatories, relatively little has been written by modern-day scholars about astronomical activities at these observatories. This research is intended to rectify this situation to some extent by gathering, cataloguing and analysing the published astronomical output of the two Observatories to see what contributions they made to science and society. It also compares their contributions with those of Sydney, Adelaide and Perth Observatories. Overall, Williamstown and Melbourne Observatories produced a prodigious amount of material on astronomy in scientific and technical journals, in reports and in newspapers. The other observatories more or less did likewise, so no observatory of those studied markedly outperformed the others in the long term, especially when account is taken of their relative resourcing in staff and equipment.
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CERN PhotoLab
1970-01-01
Professor A. Blaauw, Director general of the European Southern Observatory, with George Hampton on his right, signs the Agreement covering collaboration with CERN in the construction of the large telescope to be installed at the ESO Observatory in Chile.
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Expression of Id2 in the Second Heart Field and Cardiac Defects in Id2 Knock-Out Mice
Jongbloed, M. R. M.; Vicente-Steijn, R.; Douglas, Y. L.; Wisse, L. J.; Mori, K.; Yokota, Y.; Bartelings, M. M.; Schalij, M. J.; Mahtab, E. A.; Poelmann, R. E.; Gittenberger-De Groot, A. C.
2011-01-01
The inhibitor of differentiation Id2 is expressed in mesoderm of the second heart field, which contributes myocardial and mesenchymal cells to the primary heart tube. The role of Id2 in cardiac development is insufficiently known. Heart development was studied in sequential developmental stages in
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Improvements in geomagnetic observatory data quality
DEFF Research Database (Denmark)
Reda, Jan; Fouassier, Danielle; Isac, Anca
2011-01-01
between observatories and the establishment of observatory networks has harmonized standards and practices across the world; improving the quality of the data product available to the user. Nonetheless, operating a highquality geomagnetic observatory is non-trivial. This article gives a record...... of the current state of observatory instrumentation and methods, citing some of the general problems in the complex operation of geomagnetic observatories. It further gives an overview of recent improvements of observatory data quality based on presentation during 11th IAGA Assembly at Sopron and INTERMAGNET...
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Zinbarg, Richard E.; Revelle, William; Yovel, Iftah; Li, Wen
2005-01-01
We make theoretical comparisons among five coefficients--Cronbach's [alpha], Revelle's [beta], McDonald's [omega][sub h], and two alternative conceptualizations of reliability. Though many end users and psychometricians alike may not distinguish among these five coefficients, we demonstrate formally their nonequivalence. Specifically, whereas…
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LENUS (Irish Health Repository)
Kelly, S B
2013-07-01
The diagnostic criteria for primary-progressive multiple sclerosis (PPMS) have undergone revision over the last 20 years. Cerebrospinal fluid oligoclonal bands (CSFOBs) have received less emphasis in recent revisions of the McDonald criteria. The aim of this study was to examine the sensitivity of the diagnostic criteria for PPMS with particular reference to spinal cord criteria and examine the utility of CSFOBs in a cohort of PPMS patients.
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The Virtual Solar Observatory and the Heliophysics Meta-Virtual Observatory
Gurman, Joseph B.
2007-01-01
The Virtual Solar Observatory (VSO) is now able to search for solar data ranging from the radio to gamma rays, obtained from space and groundbased observatories, from 26 sources at 12 data providers, and from 1915 to the present. The solar physics community can use a Web interface or an Application Programming Interface (API) that allows integrating VSO searches into other software, including other Web services. Over the next few years, this integration will be especially obvious as the NASA Heliophysics division sponsors the development of a heliophysics-wide virtual observatory (VO), based on existing VO's in heliospheric, magnetospheric, and ionospheric physics as well as the VSO. We examine some of the challenges and potential of such a "meta-VO."
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The effects of McDonalds, Kentucky Fried Chicken and Pizza Hut meals on recommended diets.
Malouf, N M; Colagiuri, S
1995-06-01
The objective was to study the effect of three common takeaway meals on recommended healthy diets. New South Wales Department of Health recommended diets of 5020, 6275, 9205 and 12,540 kilojoules were used. An evening meal from each of these diets was substituted with one of three common fast food chain takeaway meals 1, 2, 3 and 5 times per week. The 3 takeaway meals were from McDonalds, Pizza Hut and Kentucky Fried Chicken. The effects of each of these meals on average daily kilojoule, fibre, fat, P/S ratio, protein and carbohydrate intakes were assessed. The takeaway meals were high in fat and kilojoules and low in fibre and therefore contravened the Dietary Guidelines for Australians. Addition of these meals increased average kilojoule consumption and the percentage energy contribution of fat and decreased the P/S ratio and fibre intake. The magnitude of these deleterious effects was directly proportional to the number of times the meals were included each week and inversely proportional to the energy content of the diet. The adverse effects were greatest with the McDonalds and Kentucky Fried Chicken meals. Takeaway meals may be convenient but the meals which were tested were too high in fat and kilojoules and too low in fibre to be a regular part of a balanced diet. Even one takeaway meal per week adversely affects the lower kilojoule recommended healthy diets.
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Cyclin D1, Id1 and EMT in breast cancer
International Nuclear Information System (INIS)
Tobin, Nicholas P; Sims, Andrew H; Lundgren, Katja L; Lehn, Sophie; Landberg, Göran
2011-01-01
Cyclin D1 is a well-characterised cell cycle regulator with established oncogenic capabilities. Despite these properties, studies report contrasting links to tumour aggressiveness. It has previously been shown that silencing cyclin D1 increases the migratory capacity of MDA-MB-231 breast cancer cells with concomitant increase in 'inhibitor of differentiation 1' (ID1) gene expression. Id1 is known to be associated with more invasive features of cancer and with the epithelial-mesenchymal transition (EMT). Here, we sought to determine if the increase in cell motility following cyclin D1 silencing was mediated by Id1 and enhanced EMT-features. To further substantiate these findings we aimed to delineate the link between CCND1, ID1 and EMT, as well as clinical properties in primary breast cancer. Protein and gene expression of ID1, CCND1 and EMT markers were determined in MDA-MB-231 and ZR75 cells by western blot and qPCR. Cell migration and promoter occupancy were monitored by transwell and ChIP assays, respectively. Gene expression was analysed from publicly available datasets. The increase in cell migration following cyclin D1 silencing in MDA-MB-231 cells was abolished by Id1 siRNA treatment and we observed cyclin D1 occupancy of the Id1 promoter region. Moreover, ID1 and SNAI2 gene expression was increased following cyclin D1 knock-down, an effect reversed with Id1 siRNA treatment. Similar migratory and SNAI2 increases were noted for the ER-positive ZR75-1 cell line, but in an Id1-independent manner. In a meta-analysis of 1107 breast cancer samples, CCND1 low /ID1 high tumours displayed increased expression of EMT markers and were associated with reduced recurrence free survival. Finally, a greater percentage of CCND1 low /ID1 high tumours were found in the EMT-like 'claudin-low' subtype of breast cancer than in other subtypes. These results indicate that increased migration of MDA-MB-231 cells following cyclin D1 silencing can be mediated by Id
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Spectroscopic classification of AT 2017cfd as a young Type Ia supernova
Vinko, J.; Wheeler, J. C.
2017-03-01
We report the spectroscopic observation of AT 2017cfd, a transient discovered by the Lick Observatory Supernova Search (LOSS) on 2017-03-16. A spectrum (range 3700-9300 Angstroms), taken with the new "Low Resolution Spectrograph-2" (LRS2) on the 10m Hobby-Eberly Telescope at McDonald Observatory by Steve Odewahn on 2017-03-18.16 UT, is similar to that of a Type Ia supernova before maximum light.
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Sabolčák, Peter
2006-01-01
FlowIDS is system which can detect some of the undesirable traffi c in computer networks (undesirable traffic could be also ie. virus activity or overloading of network) and mostly doing counteraction which are set by administrator. Information about data ows are provided by hardware of network infrastructure, eliminitaion of undesirable activity is done through changes in network hardware settings. Regarding the quantity of solution which are provided on market, I decided to focus on Cisco n...
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Kanabus, Benoît; Popa, Délia
2017-01-01
Dès lors, on entend mieux la question sur laquelle se referment les mille pages du Marx : « La pensée de Marx nous place devant la question abyssale : qu’est-ce que la vie » ? Cette question peut être reposée à nouveaux frais à l’âge du capitalisme avancé, où, comme le notait Adorno, la vie est devenue « l’idéologie de sa propre absence ». La recherche d’un autre rapport à l’idéologie vient alors prendre le relais de la lutte anti-idéologique de la théorie critique. Cette recherche part du po...
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ID3 contributes to cerebrospinal fluid seeding and poor prognosis in medulloblastoma
International Nuclear Information System (INIS)
Phi, Ji Hoon; Choi, Seung Ah; Lim, Sang-Hee; Lee, Joongyub; Wang, Kyu-Chang; Park, Sung-Hye; Kim, Seung-Ki
2013-01-01
The inhibitor of differentiation (ID) genes have been implicated as promoters of tumor progression and metastasis in many human cancers. The current study investigated the expression and functional roles of ID genes in seeding and prognosis of medulloblastoma. ID gene expression was screened in human medulloblastoma tissues. Knockdown of ID3 gene was performed in medulloblastoma cells in vitro. The expression of metastasis-related genes after ID3 knockdown was assessed. The effect of ID3 knockdown on tumor seeding was observed in an animal model in vivo. The survival of medulloblastoma patients was plotted according to the ID3 expression levels. Significantly higher ID3 expression was observed in medulloblastoma with cerebrospinal fluid seeding than tumors without seeding. Knockdown of ID3 decreased proliferation, increased apoptosis, and suppressed the migration of D283 medulloblastoma cells in vitro. In a seeding model of medulloblastoma, ID3 knockdown in vivo with shRNA inhibited the growth of primary tumors, prevented the development of leptomeningeal seeding, and prolonged animal survival. High ID3 expression was associated with shorter survival of medulloblastoma patients, especially in Group 4 medulloblastomas. High ID3 expression is associated with medullolbastoma seeding and is a poor prognostic factor, especially in patients with Group 4 tumors. ID3 may represent the metastatic/ aggressive phenotype of a subgroup of medulloblastoma
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THE PROCESS OF WASTE MANAGEMENT IN POST-CONSUMER PACKAGING: CASE STUDY MCDONALD'S
Directory of Open Access Journals (Sweden)
Robson dos Santos
2013-09-01
Full Text Available This research considers the increasing concern of society in general environmental issues, shows the importance of an Environmental Management System to improve the image of a company towards society in which it is embedded. Shows that proper waste management can result in financial and environmental benefits for companies that practice. To address the practical issues of the theme, was chosen the company McDonald's, as a service company fast food, that have a quantity of waste, and creates conditions for application of the techniques of environmental management in this sector. Thus, this article aims to demonstrate through case study and descriptive research, the commitment that this large network of fast-food has with the preservation of the environment through its waste management and investments in economic, social and environmental the country.
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ID-pilet teeb Tallinnas võidukäiku / Anneli Lepp
Lepp, Anneli
2006-01-01
Vt. ka Postimees : na russkom jazõke 12. jaan. lk 3. Tallinna transpordiameti peaökonomisti Mart Moosuse sõnul moodustas ID-pilet 60,7% ühistranspordi piletituludest, Tartus oli vastav näitaja aga alla 1%. Tartut teenindava bussifirma AS Connex Eesti finantsjuht Tiina Telling peab suure erinevuse põhjuseks asjaolu, et Tallinnas on ID-pilet paberpiletist 40-88% soodsam, Tartus hinnavahe aga puudub või on lausa negatiivne ID-pileti kahjuks. Lisa: ID-pilet
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Directory of Open Access Journals (Sweden)
Hendro Agus Prakoso
2016-09-01
berita kedua media tersebut. Frekuensi berita berjumlah 107 di Republika.co.id dan 51 berita di Tempo.co.id Ragam berita Republika.co.id didominasi konsep Spesialisasi sebesar 22,4% dari 107 berita, sedangkan pada Tempo.co.id didominasi konsep Nama baik sebesar 23,5% dari 51 berita. Sumber berita pada Republika.co.id mayoritas berasal dari Liputan langsung sebesar 42,9% dari 107 berita sedangkan pada Tempo.co.id mayoritas berasal dari Intelektual sebesar 54,9% dari 51 berita.
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Directory of Open Access Journals (Sweden)
Philipp Schwenkenbecher
2016-09-01
Full Text Available The 2010 McDonald criteria were developed to allow a more rapid diagnosis of relapsing-remitting multiple sclerosis (MS by only one MRI of the brain. Although cerebrospinal fluid (CSF is not a mandatory part of the latest criteria, the evidence of an intrathecal humoral immunoreaction in the form of oligoclonal bands (OCB is crucial in the diagnostic workup. To date, the impact of the 2010 McDonald criteria on the prevalence of OCB has not been investigated. We retrospectively evaluated data of 325 patients with a clinical relapse suggestive of demyelination that were treated in a German university hospital between 2010 and 2015. One hundred thirty-six patients (42% were diagnosed with MS and 189 patients with CIS when the criteria of 2010 were applied. The criteria of 2005 allowed only 70 patients (22% to be designated as MS. In contrast, the prevalence of OCB was marginal affected in MS patients with 96% for the criteria of 2010 and 98.5% for the criteria of 2005. In conclusion, OCB are prevalent in most MS patients and reflect the chronic inflammatory nature of the disease. We recommend CSF examination to exclude alternative diagnoses and reevaluation of the diagnosis MS in patients with negative OCB.
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Epigenetic inactivation of inhibitor of differentiation 4 (Id4) correlates with prostate cancer
International Nuclear Information System (INIS)
Sharma, Pankaj; Chinaranagari, Swathi; Patel, Divya; Carey, Jason; Chaudhary, Jaideep
2012-01-01
The inhibitor of DNA-binding (Id) proteins, Id1–4 are negative regulators of basic helix-loop-helix (bHLH) transcription factors. As key regulators of cell cycle and differentiation, expression of Id proteins are increasingly observed in many cancers and associated with aggressiveness of the disease. Of all the four Id proteins, the expression of Id1, Id2, and to a lesser extent, Id3 in prostate cancer and the underlying molecular mechanism is relatively well known. On the contrary, our previous results demonstrated that Id4 acts as a potential tumor suppressor in prostate cancer. In the present study, we extend these observations and demonstrate that Id4 is down-regulated in prostate cancer due to promoter hypermethylation. We used prostate cancer tissue microarrays to investigate Id4 expression. Methylation specific PCR on bisulfite treated DNA was used to determine methylation status of Id4 promoter in laser capture micro-dissected normal, stroma and prostate cancer regions. High Id4 expression was observed in the normal prostate epithelial cells. In prostate cancer, a stage-dependent decrease in Id4 expression was observed with majority of high grade cancers showing no Id4 expression. Furthermore, Id4 expression progressively decreased in prostate cancer cell line LNCaP and with no expression in androgen-insensitive LNCaP-C81 cell line. Conversely, Id4 promoter hypermethylation increased in LNCaP-C81 cells suggesting epigenetic silencing. In prostate cancer samples, loss of Id4 expression was also associated with promoter hypermethylation. Our results demonstrate loss of Id4 expression in prostate cancer due to promoter hypermethylation. The data strongly support the role of Id4 as a tumor suppressor
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Schieve, Laura A.; Clayton, Heather B.; Durkin, Maureen S.; Wingate, Martha S.; Drews-Botsch, Carolyn
2015-01-01
While studies report associations between perinatal outcomes and both autism spectrum disorder (ASD) and intellectual disability (ID), there has been little study of ASD with versus without co-occurring ID. We compared perinatal risk factors among 7547 children in the 2006-2010 Autism and Developmental Disability Monitoring Network classified as…
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AMI-LA 15 GHz Observation of the Type IIP Supernova SN 2017eaw
Bright, Joe; Mooley, Kunal; Fender, Rob; Horesh, Assaf
2017-05-01
SN 2017eaw was discovered by Patrick Wiggins on 2017 May 14.24 and confirmed as a transient object (located in NGC 6946, at a distance of around 5.5 Mpc) in follow up observations from the McDonald observatory (ATel #10372).
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Radial velocities of RR Lyrae stars
International Nuclear Information System (INIS)
Hawley, S.L.; Barnes, T.G. III
1985-01-01
283 spectra of 57 RR Lyrae stars have been obtained using the 2.1-m telescope at McDonald Observatory. Radial velocities were determined using a software cross-correlation technique. New mean radial velocities were determined for 46 of the stars. 11 references
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Achieving Payoffs from an Industry Cloud Ecosystem at BankID
DEFF Research Database (Denmark)
Eaton, Ben; Hallingby, Hanne Kristine; Nesse, Per-Jonny
2014-01-01
BankID is an industry cloud owned by Norwegian banks. It provides electronic identity, authentication and electronic signing capabilities for banking, merchant and government services. More than 60% of the population uses BankID services. As the broader ecosystem around BankID evolved, challenges......—arising from tensions between different parts of the ecosystem—had to be resolved. The four lessons learned from the BankID case will help others to build an industry cloud and establish a healthy ecosystem to service a broad user base....
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Griffith Observatory: Hollywood's Celestial Theater
Margolis, Emily A.; Dr. Stuart W. Leslie
2018-01-01
The Griffith Observatory, perched atop the Hollywood Hills, is perhaps the most recognizable observatory in the world. Since opening in 1935, this Los Angeles icon has brought millions of visitors closer to the heavens. Through an analysis of planning documentation, internal newsletters, media coverage, programming and exhibition design, I demonstrate how the Observatory’s Southern California location shaped its form and function. The astronomical community at nearby Mt. Wilson Observatory and Caltech informed the selection of instrumentation and programming, especially for presentations with the Observatory’s Zeiss Planetarium, the second installed in the United States. Meanwhile the Observatory staff called upon some of Hollywood’s best artists, model makers, and scriptwriters to translate the latest astronomical discoveries into spectacular audiovisual experiences, which were enhanced with Space Age technological displays on loan from Southern California’s aerospace companies. The influences of these three communities- professional astronomy, entertainment, and aerospace- persist today and continue to make Griffith Observatory one of the premiere sites of public astronomy in the country.
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Teacher Professional Development in Laredo, TX
Finkelstein, Keely D.; Macri, L. M.; Hemenway, M.; Wetzel, M.; Preston, S.; Rood, M.
2014-01-01
In the fall of 2012, McDonald Observatory, Texas A&M University, and Texas A&M International University conducted a series of workshops on astronomy content for 5th - 8th grade teachers in Laredo, Texas. Three one-day workshops were held at the Lamar Bruni Vergara Planetarium of Texas A&M International University, using a mix of in-person and distance learning technology. Texas A&M professor Lucas Macri gave public talks in English and Spanish, and a lunch-time presentation to the teachers. A series of evaluation tools were used to assess the success of the workshops. A Nominal Group Technique (NGT) discussion was used, through which groups developed consensus answers about their learning, expectations for classroom use, and satisfaction with the workshop. The Astronomy/Space Science Test (MOSART Grades 5-8) was also issued as a pre- and post-test to assess gains in knowledge. Teacher consensus was that the materials and activities of the workshop had been helpful for learning and that they expected to use many of them in their classrooms. However, the evaluation also showed that teachers would have preferred the Observatory educator be physically present for all workshops. Past video-conferencing workshops, where local facilitators first participated in workshops at the Observatory, showed better feedback and results concerning this point. Comparing those results to the present case, we conclude that more clearly defined roles and better training for the science specialists and local facilitators would improve the video conference experience for the teachers. Comparison of pre- and post-test results showed improved teacher knowledge. An additional benefit of this project was the further development of partnerships between McDonald Observatory and Texas A&M International University, which has resulted in further education projects, including a video-conference presentation series to eight-grade students and their families. This secondary project focused on
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IMI's CANCER-ID: Status of liquid biopsy standardization
Pantel, Klaus; Terstappen, Leon W. M. M.; Baggiani, Barbara; Krahn, Thomas; Schlange, Thomas
The CANCER-ID (www.cancer-id.eu) consortium was established in early 2015 with more than 30 partners as part of the Innovative Medicines Initiative (IMI), Europe's largest public-private partnership funded in equal parts by the European Union and the European Federation of Pharmaceutical Industries
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Security analysis for biometric data in ID documents
Schimke, S.; Kiltz, S.; Vielhauer, C.; Kalker, A.A.C.M.
2005-01-01
In this paper we analyze chances and challenges with respect to the security of using biometrics in ID documents. We identify goals for ID documents, set by national and international authorities, and discuss the degree of security, which is obtainable with the inclusion of biometric into documents
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A brief review of revocable ID-based public key cryptosystem
Directory of Open Access Journals (Sweden)
Tsu-Yang Wu
2016-03-01
Full Text Available The design of ID-based cryptography has received much attention from researchers. However, how to revoke the misbehaviour/compromised user in ID-based public key cryptosystem becomes an important research issue. Recently, Tseng and Tsai proposed a novel public key cryptosystem called revocable ID-based public key cryptosystem (RIBE to solve the revocation problem. Later on, numerous research papers based on the Tseng-Tsai key RIBE were proposed. In this paper, we brief review Tseng and Tsai's RIBE. We hope this review can help the readers to understand the Tseng and Tsai's revocable ID-based public key cryptosystem.
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Spectrophotometry of Pluto from 3500 to 7350 A
International Nuclear Information System (INIS)
Barker, E.S.; Cochran, W.D.; Cochran, A.L.; Texas, University, Austin, Tex.)
1980-01-01
Spectra of Pluto have been obtained on six nights during February 1979 by the use of the Cassegrain Digicon spectrograph on the 2.1-m Struve reflector and the IDS spectrograph on the 2.7-m reflector of McDonald Observatory. These spectra, with nominal resolution of 6-7 A, have been reduced to relative fluxes. Relative albedos were then calculated using the solar irradiances of Arvesen et al. (1969). The spectra taken in the blue show no indication of the upturn in albedo at wavelengths less than 3800 A previously reported by Fix, et al. (1970). The lack of a UV upturn cannot be interpreted in terms of a Rayleigh scattering atmosphere unless the albedo of the underlying surface is known. From the lack of methane absorption at the wavelength of the 6190- or 7270-A methane bands, an upper limit of 1-3 m-am of gaseous CH4 is derived. The albedo curve has a constant slope between 3500 and 7300 A. The only other solar system body which has this feature is an S-type asteroid
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Id1 represses osteoclast-dependent transcription and affects bone formation and hematopoiesis.
Directory of Open Access Journals (Sweden)
April S Chan
2009-11-01
Full Text Available The bone-bone marrow interface is an area of the bone marrow microenvironment in which both bone remodeling cells, osteoblasts and osteoclasts, and hematopoietic cells are anatomically juxtaposed. The close proximity of these cells naturally suggests that they interact with one another, but these interactions are just beginning to be characterized.An Id1(-/- mouse model was used to assess the role of Id1 in the bone marrow microenvironment. Micro-computed tomography and fracture tests showed that Id1(-/- mice have reduced bone mass and increased bone fragility, consistent with an osteoporotic phenotype. Osteoclastogenesis and pit formation assays revealed that loss of Id1 increased osteoclast differentiation and resorption activity, both in vivo and in vitro, suggesting a cell autonomous role for Id1 as a negative regulator of osteoclast differentiation. Examination by flow cytometry of the hematopoietic compartment of Id1(-/- mice showed an increase in myeloid differentiation. Additionally, we found increased expression of osteoclast genes, TRAP, Oscar, and CTSK in the Id1(-/- bone marrow microenvironment. Lastly, transplantation of wild-type bone marrow into Id1(-/- mice repressed TRAP, Oscar, and CTSK expression and activity and rescued the hematopoietic and bone phenotype in these mice.In conclusion, we demonstrate an osteoporotic phenotype in Id1(-/- mice and a mechanism for Id1 transcriptional control of osteoclast-associated genes. Our results identify Id1 as a principal player responsible for the dynamic cross-talk between bone and bone marrow hematopoietic cells.
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Observations of faint comets at McDonald Observatory: 1978-1980
Barker, E. S.; Cochran, A. L.; Rybski, P. M.
1981-01-01
Modern observational techniques, developed for spectroscopy and photometry of faint galaxies and quasars, successfully applied to faint comets on the 2.7 m telescope. The periodic comets Van Biesbrock, Ashbrook-Jackson, Schwassmann-Wachmann 1, Tempel 2, Encke, Forbes, Brooks 2, Stephan-Oterma and the new comets Bradfield (19791), Bowell (1980b), Chernis-Petrauskas (1980k) were observed. The comets ranged in magnitude from 10th to 20th magnitude. For comets fainter than 19th magnitude, reflectance spectra at 100A resolution and area photometry were obtained. On comets of 17th or 18th magnitude, spectrometric scans (6A resolution) of the nucleus or inner coma region. On those comets which are brighter than 16th magnitude spatial spectrophotometric (6A resolution) studies of the inner and extended comae were done. An extensive spatial study of the comae of P/Encke and P/Stephen-Oterma, correlated with heliocentric distance is taking place. The observing process used is described and examples of the results obtained to date are discussed.
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Astrometric observations of Saturn's satellites from McDonald Observatory, 1972
Abbot, R. I.; Mulholland, J. D.; Shelus, P. J.
1975-01-01
Observations of Saturn's satellites have been reduced by means of secondary reference stars obtained by reduction of Palomar Sky Survey plates. This involved the use of 29 SAO stars and plate overlap technique to determine the coordinates of 59 fainter stars in the satellite field. Fourteen plate constants were determined for each of the two PSS plates. Comparison of two plate measurement and reduction techniques on the satellite measures appears to demonstrate the existence of a serious background gradient effect and the utility of microdensitometry to eliminate this error source in positional determinations of close satellites.
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US Naval Observatory Hourly Observations
National Oceanic and Atmospheric Administration, Department of Commerce — Hourly observations journal from the National Observatory in Washington DC. The observatory is the first station in the United States to produce hourly observations...
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La certificazione professionale I&D in Europa
Franco, Augusta
2003-01-01
The statement points out the activity of I&D European associations in the field of competences' certification, in ECIA federation's area as well as in the national one. In the statement there are references on history and outcomes of DECIDoc project; objectives and operative stages of CERTIDoc project, promoted by ECIA; and enterprises of I&D associations in France, Spain, Germany and Italy. Secondly, it is illustrated the activity of Italian librarians and archivists associatio...
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Archer, Julian; Nunn, Suzanne; Regan de Bere, Sam
2017-09-01
Medical regulation is rapidly changing with claims that systems such as revalidation/relicensing will reassure the public. Yet the impact of such initiatives is unknown. Using the principles of efficiency, calculability, predictability and control through technology, identified by Ritzer, and exampled by the McDonalds business model, we analyzed interviews with doctors between May 2012-Dec 2013 which focused on doctor experiences of appraisal and revalidation in SW England. The research found significant changes in appraisals since the launch of revalidation in December 2012. Appraisal has been standardized with a list of supporting information that must be collected by doctors. The success of implementation is measured in the numbers of appraisals completed but less is known about the quality of the appraisal itself. Such efficiencies have been supported by IT systems that themselves might be at risk of driving the process. There are potential advantages to McDonaldization including appraisals available to all, not just for doctors working in the NHS, and a potentially more appetizing recipe for their completion. As yet a state of McAppraisal has not been reached; with a complete transfer of trust in the doctor to trust in the appraisal process within revalidation. However policymakers will need to continue to ensure that regulatory initiatives, such as revalidation, are not just a process for their own sake. Copyright © 2017 Elsevier B.V. All rights reserved.
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People with ID as interviewers and co-researchers: experiences and reflection.
Lieshout, H. van
2012-01-01
Aim: To share the experience of working with people with intellectual disabilities (ID) as interviewers in a qualitative study about community participation of people with ID. We reflect on two perspectives: the interviewers and the researchers. Method: Eighteen people with ID were interviewed by
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Observatory data and the Swarm mission
DEFF Research Database (Denmark)
Macmillan, S.; Olsen, Nils
2013-01-01
products. We describe here the preparation of the data set of ground observatory hourly mean values, including procedures to check and select observatory data spanning the modern magnetic survey satellite era. We discuss other possible combined uses of satellite and observatory data, in particular those......The ESA Swarm mission to identify and measure very accurately the different magnetic signals that arise in the Earth’s core, mantle, crust, oceans, ionosphere and magnetosphere, which together form the magnetic field around the Earth, has increased interest in magnetic data collected on the surface...... of the Earth at observatories. The scientific use of Swarm data and Swarm-derived products is greatly enhanced by combination with observatory data and indices. As part of the Swarm Level-2 data activities plans are in place to distribute such ground-based data along with the Swarm data as auxiliary data...
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An online ID identification system for liquefied-gas cylinder plant
He, Jin; Ding, Zhenwen; Han, Lei; Zhang, Hao
2017-11-01
An automatic ID identification system for gas cylinders' online production was developed based on the production conditions and requirements of the Technical Committee for Standardization of Gas Cylinders. A cylinder ID image acquisition system was designed to improve the image contrast of ID regions on gas cylinders against the background. Then the ID digits region was located by the CNN template matching algorithm. Following that, an adaptive threshold method based on the analysis of local average grey value and standard deviation was proposed to overcome defects of non-uniform background in the segmentation results. To improve the single digit identification accuracy, two BP neural networks were trained respectively for the identification of all digits and the easily confusable digits. If the single digit was classified as one of confusable digits by the former BP neural network, it was further tested by the later one, and the later result was taken as the final identification result of this single digit. At last, the majority voting was adopted to decide the final identification result for the 6-digit cylinder ID. The developed system was installed on a production line of a liquefied-petroleum-gas cylinder plant and worked in parallel with the existing weighing step on the line. Through the field test, the correct identification rate for single ID digit was 94.73%, and none of the tested 2000 cylinder ID was misclassified through the majority voting.
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High Resolution Stellar Spectroscopy with VBT Echelle Spectrometer
Indian Academy of Sciences (India)
Easy operations. We finally preferred the all transmitting system for the spectrometer with the optical surfaces anti-reflection coated to optimize the throughput rather than reflecting cameras with central obscurations. Following other optimized throughput spectrometers like. Sandiford at McDonald Observatory (McCarthy et al ...
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Erinda, Aisyah; Kumadji, Srikandi; Sunarti,
2016-01-01
The purpose of this study to determine factor of consumer preference for McDonalds and the effect of Purchasing Decision. There are 21 variable factors of consumer preferences used in this study as well as its influence on the purchase decision. The type of this research is explanatory research with quantitative approach. Location of the study was conducted in Indonesia and Malaysia. The sampling technique of this study used formula from Machin and Campbell (1987:89). The sample in this study...
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In Brief: Deep-sea observatory
Showstack, Randy
2008-11-01
The first deep-sea ocean observatory offshore of the continental United States has begun operating in the waters off central California. The remotely operated Monterey Accelerated Research System (MARS) will allow scientists to monitor the deep sea continuously. Among the first devices to be hooked up to the observatory are instruments to monitor earthquakes, videotape deep-sea animals, and study the effects of acidification on seafloor animals. ``Some day we may look back at the first packets of data streaming in from the MARS observatory as the equivalent of those first words spoken by Alexander Graham Bell: `Watson, come here, I need you!','' commented Marcia McNutt, president and CEO of the Monterey Bay Aquarium Research Institute, which coordinated construction of the observatory. For more information, see http://www.mbari.org/news/news_releases/2008/mars-live/mars-live.html.
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An astronomical observatory for Peru
del Mar, Juan Quintanilla; Sicardy, Bruno; Giraldo, Víctor Ayma; Callo, Víctor Raúl Aguilar
2011-06-01
Peru and France are to conclude an agreement to provide Peru with an astronomical observatory equipped with a 60-cm diameter telescope. The principal aims of this project are to establish and develop research and teaching in astronomy. Since 2004, a team of researchers from Paris Observatory has been working with the University of Cusco (UNSAAC) on the educational, technical and financial aspects of implementing this venture. During an international astronomy conference in Cusco in July 2009, the foundation stone of the future Peruvian Observatory was laid at the top of Pachatusan Mountain. UNSAAC, represented by its Rector, together with the town of Oropesa and the Cusco regional authority, undertook to make the sum of 300,000€ available to the project. An agreement between Paris Observatory and UNSAAC now enables Peruvian students to study astronomy through online teaching.
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Strong CO+ and {{\\rm{N}}}_{2}^{+} Emission in Comet C/2016 R2 (Pan-STARRS)
Cochran, Anita L.; McKay, Adam J.
2018-02-01
We report on imaging and spectroscopic observations of comet C/2016 R2 (Pan-STARRS) obtained with the 0.8 m and 2.7 m telescopes of McDonald Observatory in 2017 November and December, respectively. The comet was at a heliocentric distance greater than 3 au during both sets of observations. The images showed a well-developed tail with properties that suggested it was an ion tail. The spectra confirmed that we were observing well-developed bands of CO+ and {{{N}}}2+. The {{{N}}}2+ detection was unequivocally cometary and was one of the strongest bands of {{{N}}}2+ detected in a comet spectrum. We derived the ratio of these two ions and from that we were able to derive that N2/CO = 0.15. This is the highest such ratio reported for a comet. This Letter includes data taken at The McDonald Observatory of The University of Texas at Austin.
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Absolute dimensions and masses of eclipsing binaries. V. IQ Persei
International Nuclear Information System (INIS)
Lacy, C.H.; Frueh, M.L.; McDonald Observatory, Austin)
1985-01-01
New photometric and spectroscopic observations of the 1.7 day eclipsing binary IQ Persei (B8 + A6) have been analyzed to yield very accurate fundamental properties of the system. Reticon spectroscopic observations obtained at McDonald Observatory were used to determine accurate radial velocities of both stars in this slightly eccentric large light-ratio binary. A new set of VR light curves obtained at McDonald Observatory were analyzed by synthesis techniques, and previously published UBV light curves were reanalyzed to yield accurate photometric orbits. Orbital parameters derived from both sets of photometric observations are in excellent agreement. The absolute dimensions, masses, luminosities, and apsidal motion period (140 yr) derived from these observations agree well with the predictions of theoretical stellar evolution models. The A6 secondary is still very close to the zero-age main sequence. The B8 primary is about one-third of the way through its main-sequence evolution. 27 references
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Daily variation characteristics at polar geomagnetic observatories
Lepidi, S.; Cafarella, L.; Pietrolungo, M.; Di Mauro, D.
2011-08-01
This paper is based on the statistical analysis of the diurnal variation as observed at six polar geomagnetic observatories, three in the Northern and three in the Southern hemisphere. Data are for 2006, a year of low geomagnetic activity. We compared the Italian observatory Mario Zucchelli Station (TNB; corrected geomagnetic latitude: 80.0°S), the French-Italian observatory Dome C (DMC; 88.9°S), the French observatory Dumont D'Urville (DRV; 80.4°S) and the three Canadian observatories, Resolute Bay (RES; 83.0°N), Cambridge Bay (CBB; 77.0°N) and Alert (ALE, 87.2°N). The aim of this work was to highlight analogies and differences in daily variation as observed at the different observatories during low geomagnetic activity year, also considering Interplanetary Magnetic Field conditions and geomagnetic indices.
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Observatories of Sawai Jai Singh II
Johnson-Roehr, Susan N.
Sawai Jai Singh II, Maharaja of Amber and Jaipur, constructed five observatories in the second quarter of the eighteenth century in the north Indian cities of Shahjahanabad (Delhi), Jaipur, Ujjain, Mathura, and Varanasi. Believing the accuracy of his naked-eye observations would improve with larger, more stable instruments, Jai Singh reengineered common brass instruments using stone construction methods. His applied ingenuity led to the invention of several outsize masonry instruments, the majority of which were used to determine the coordinates of celestial objects with reference to the local horizon. During Jai Singh's lifetime, the observatories were used to make observations in order to update existing ephemerides such as the Zīj-i Ulugh Begī. Jai Singh established communications with European astronomers through a number of Jesuits living and working in India. In addition to dispatching ambassadorial parties to Portugal, he invited French and Bavarian Jesuits to visit and make use of the observatories in Shahjahanabad and Jaipur. The observatories were abandoned after Jai Singh's death in 1743 CE. The Mathura observatory was disassembled completely before 1857. The instruments at the remaining observatories were restored extensively during the nineteenth and twentieth centuries.
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Byurakan Astrophysical Observatory as Cultural Centre
Mickaelian, A. M.; Farmanyan, S. V.
2017-07-01
NAS RA V. Ambartsumian Byurakan Astrophysical Observatory is presented as a cultural centre for Armenia and the Armenian nation in general. Besides being scientific and educational centre, the Observatory is famous for its unique architectural ensemble, rich botanical garden and world of birds, as well as it is one of the most frequently visited sightseeing of Armenia. In recent years, the Observatory has also taken the initiative of the coordination of the Cultural Astronomy in Armenia and in this field, unites the astronomers, historians, archaeologists, ethnographers, culturologists, literary critics, linguists, art historians and other experts. Keywords: Byurakan Astrophysical Observatory, architecture, botanic garden, tourism, Cultural Astronomy.
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International Nuclear Information System (INIS)
Hojvat, C.
1997-03-01
The Pierre Auger Observatory is an international collaboration for the detailed study of the highest energy cosmic rays. It will operate at two similar sites, one in the northern hemisphere and one in the southern hemisphere. The Observatory is designed to collect a statistically significant data set of events with energies greater than 10 19 eV and with equal exposures for the northern and southern skies
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Supporting co-creation with software, the idSpace platform
Van Rosmalen, Peter; Boon, Jo; Bitter-Rijpkema, Marlies; Sie, Rory; Sloep, Peter
2014-01-01
Innovation, in general, requires teamwork among specialist of different disciplines. The idSpace project developed ideas on how teams of collaborating innovators could best be supported. These ideas were embodied in a platform that the project developed. This idSpace platform allows its users to
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An international network of magnetic observatories
Love, Jeffrey J.; Chulliat, A.
2013-01-01
Since its formation in the late 1980s, the International Real-Time Magnetic Observatory Network (INTERMAGNET), a voluntary consortium of geophysical institutes from around the world, has promoted the operation of magnetic observatories according to modern standards [eg. Rasson, 2007]. INTERMAGNET institutes have cooperatively developed infrastructure for data exchange and management ads well as methods for data processing and checking. INTERMAGNET institute have also helped to expand global geomagnetic monitoring capacity, most notably by assisting magnetic observatory institutes in economically developing countries by working directly with local geophysicists. Today the INTERMAGNET consortium encompasses 57 institutes from 40 countries supporting 120 observatories (see Figures 1a and 1b). INTERMAGNET data record a wide variety of time series signals related to a host of different physical processes in the Earth's interiors and in the Earth's surrounding space environment [e.g., Love, 2008]. Observatory data have always had a diverse user community, and to meet evolving demand, INTERMAGNET has recently coordinated the introduction of several new data services.
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A Contextual Model for Identity Management (IdM) Interfaces
Fuller, Nathaniel J.
2014-01-01
The usability of Identity Management (IdM) systems is highly dependent upon design that simplifies the processes of identification, authentication, and authorization. Recent findings reveal two critical problems that degrade IdM usability: (1) unfeasible techniques for managing various digital identifiers, and (2) ambiguous security interfaces.…
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DEFF Research Database (Denmark)
Schøsler, Jørn
2013-01-01
Der gives en analyse af begreberne 'evidens' og 'medfødte idéer' hos Descartes og Locke samt hos de franske oplysningsfilosoffer.......Der gives en analyse af begreberne 'evidens' og 'medfødte idéer' hos Descartes og Locke samt hos de franske oplysningsfilosoffer....
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How to save distressed IDS-physician marriages: a case study.
Collins, H; Johnson, B A
1998-04-01
A hospital-driven IDS that encounters serious problems resulting from ownership of a physician practice should address those problems by focusing on three core areas: vision and leadership, effectiveness of operations, and physician compensation arrangements. If changes in these areas do not lead to improvements, the IDS may need to consider organizational restructuring. In one case study, a hospital-driven IDS faced the problem of owning a poorly performing MSO with a captive physician group. The IDS's governing board determined that the organization lacked effective communication with the physicians and that realization of the organization's vision would require greater physician involvement in organizational decision making. The organization is expected to undergo some corporate reorganization in which physicians will acquire an equity interest in the enterprise.
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A Good IDS Response Protocol of MANET Containment Strategies
Cheng, Bo-Chao; Chen, Huan; Tseng, Ryh-Yuh
Much recent research concentrates on designing an Intrusion Detection System (IDS) to detect the misbehaviors of the malicious node in MANET with ad-hoc and mobility natures. However, without rapid and appropriate IDS response mechanisms performing follow-up management services, even the best IDS cannot achieve the desired primary goal of the incident response. A competent containment strategy is needed to limit the extent of an attack in the Incident Response Life Cycle. Inspired by the T-cell mechanisms in the human immune system, we propose an efficient MANET IDS response protocol (T-SecAODV) that can rapidly and accurately disseminate alerts of the malicious node attacks to other nodes so as to modify their AODV routing tables to isolate the malicious nodes. Simulations are conducted by the network simulator (Qualnet), and the experiment results indicate that T-SecAODV is able to spread alerts steadily while greatly reduce faulty rumors under simultaneous multiple malicious node attacks.
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Lunde Larsen, L S; Larsson, H B W; Frederiksen, J L
2010-09-01
The diagnosis of MS is based on the revised McDonald criteria and is multidisciplinary. Both clinical and paraclinical measures are included. High-field magnetic resonance imaging (MRI) is becoming increasingly available and it is therefore necessary to clarify possible advantages of high-field MRI in MS. The aim of this paper was to review MRI studies in MS where a direct comparison of MRI at high field with MRI at 1-1.5 tesla (T) had been performed. The studies evaluated were found by searching Pubmed with relevant terms including MeSH terms. The reviewed studies all found the conspicuity of lesions to be better at high field. Of the seven studies, six found more and bigger lesions at high-field MRI. In the present paper, the relevant MRI sequences are evaluated in detail. The detection of more lesions at high-field strength did not seem to lead to earlier diagnosis of clinically definite multiple sclerosis. Further larger studies of patients with clinically isolated syndromes are needed to settle the question of a diagnostic consequence of high-field imaging in MS. We suggest that the next revision of the McDonald diagnostic criteria include a recommendation of field strength.
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Ekspert : mobiil-ID kasutamine valimistel turvariske ei tekita / Holger Roonemaa
Roonemaa, Holger
2008-01-01
E-valimiste projektijuhi Taavi Martensi väitel pole põhjust kahelda mobiil-ID turvalisuses. Valimiskomisjoni esimehe Heiki Sibula meelest peaks m-ID kaarte välja andma kodakondsus- ja migratsiooniamet
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Picture This: How to Establish an Effective School ID Card Program
Finkelstein, David
2013-01-01
Most school districts do not have an ID card policy that everyone knows and follows, yet. many school districts are implementing ID card programs to address concerns about safety, efficiency, and convenience. A well-thought-out ID card program leads to greater security and smoother operations throughout the school and should thus be a priority.…
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Inhibitor of differentiation 4 (Id4) is a potential tumor suppressor in prostate cancer
International Nuclear Information System (INIS)
Carey, Jason PW; Asirvatham, Ananthi J; Galm, Oliver; Ghogomu, Tandeih A; Chaudhary, Jaideep
2009-01-01
Inhibitor of differentiation 4 (Id4), a member of the Id gene family is also a dominant negative regulator of basic helix loop helix (bHLH) transcription factors. Some of the functions of Id4 appear to be unique as compared to its other family members Id1, Id2 and Id3. Loss of Id4 gene expression in many cancers in association with promoter hypermethylation has led to the proposal that Id4 may act as a tumor suppressor. In this study we provide functional evidence that Id4 indeed acts as a tumor suppressor and is part of a cancer associated epigenetic re-programming. Data mining was used to demonstrate Id4 expression in prostate cancer. Methylation specific polymerase chain reaction (MSP) analysis was performed to understand molecular mechanisms associated with Id4 expression in prostate cancer cell lines. The effect of ectopic Id4 expression in DU145 cells was determined by cell cycle analysis (3H thymidine incorporation and FACS), expression of androgen receptor, p53 and cyclin dependent kinase inhibitors p27 and p21 by a combination of RT-PCR, real time-PCR, western blot and immuno-cytochemical analysis. Id4 expression was down-regulated in prostate cancer. Id4 expression was also down-regulated in prostate cancer line DU145 due to promoter hyper-methylation. Ectopic Id4 expression in DU145 prostate cancer cell line led to increased apoptosis and decreased cell proliferation due in part by an S-phase arrest. In addition to S-phase arrest, ectopic Id4 expression in PC3 cells also resulted in prolonged G2/M phase. At the molecular level these changes were associated with increased androgen receptor (AR), p21, p27 and p53 expression in DU145 cells. The results suggest that Id4 acts directly as a tumor suppressor by influencing a hierarchy of cellular processes at multiple levels that leads to a decreased cell proliferation and change in morphology that is possibly mediated through induction of previously silenced tumor suppressors
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Id-1 is not expressed in the luminal epithelial cells of mammary glands
International Nuclear Information System (INIS)
Uehara, Norihisa; Chou, Yu-Chien; Galvez, Jose J; Candia, Paola de; Cardiff, Robert D; Benezra, Robert; Shyamala, Gopalan
2003-01-01
The family of inhibitor of differentiation/DNA binding (Id) proteins is known to regulate development in several tissues. One member of this gene family, Id-1, has been implicated in mammary development and carcinogenesis. Mammary glands contain various cell types, among which the luminal epithelial cells are primarily targeted for proliferation, differentiation and carcinogenesis. Therefore, to assess the precise significance of Id-1 in mammary biology and carcinogenesis, we examined its cellular localization in vivo using immunohistochemistry. Extracts of whole mammary glands from wild type and Id-1 null mutant mice, and tissue sections from paraffin-embedded mouse mammary glands from various developmental stages and normal human breast were subjected to immunoblot and immunohistochemical analyses, respectively. In both these procedures, an anti-Id-1 rabbit polyclonal antibody was used for detection of Id-1. In immunoblot analyses, using whole mammary gland extracts, Id-1 was detected. In immunohistochemical analyses, however, Id-1 was not detected in the luminal epithelial cells of mammary glands during any stage of development, but it was detected in vascular endothelial cells. Id-1 is not expressed in the luminal epithelial cells of mammary glands
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Seafloor Observatory Science: a Review
Directory of Open Access Journals (Sweden)
L. Beranzoli
2006-06-01
Full Text Available The ocean exerts a pervasive influence on Earths environment. It is therefore important that we learn how this system operates (NRC, 1998b; 1999. For example, the ocean is an important regulator of climate change (e.g., IPCC, 1995. Understanding the link between natural and anthropogenic climate change and ocean circulation is essential for predicting the magnitude and impact of future changes in Earths climate. Understanding the ocean, and the complex physical, biological, chemical, and geological systems operating within it, should be an important goal for the opening decades of the 21st century. Another fundamental reason for increasing our understanding of ocean systems is that the global economy is highly dependent on the ocean (e.g., for tourism, fisheries, hydrocarbons, and mineral resources (Summerhayes, 1996. The establishment of a global network of seafloor observatories will help to provide the means to accomplish this goal. These observatories will have power and communication capabilities and will provide support for spatially distributed sensing systems and mobile platforms. Sensors and instruments will potentially collect data from above the air-sea interface to below the seafloor. Seafloor observatories will also be a powerful complement to satellite measurement systems by providing the ability to collect vertically distributed measurements within the water column for use with the spatial measurements acquired by satellites while also providing the capability to calibrate remotely sensed satellite measurements (NRC, 2000. Ocean observatory science has already had major successes. For example the TAO array has enabled the detection, understanding and prediction of El Niño events (e.g., Fujimoto et al., 2003. This paper is a world-wide review of the new emerging Seafloor Observatory Science, and describes both the scientific motivations for seafloor observatories and the technical solutions applied to their architecture. A
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Directory of Open Access Journals (Sweden)
Philipp Schwenkenbecher
2017-09-01
Full Text Available While the revised McDonald criteria of 2010 allow for the diagnosis of multiple sclerosis (MS in an earlier stage, there is still a need to identify the risk factors for conversion to MS in patients with clinically isolated syndrome (CIS. Since the latest McDonald criteria were established, the prognostic role of cerebrospinal fluid (CSF and visual evoked potentials (VEP in CIS patients is still poorly defined. We conducted a monocentric investigation including patients with CIS in the time from 2010 to 2015. Follow-ups of 120 patients revealed that 42% converted to MS. CIS patients with positive oligoclonal bands (OCB were more than twice as likely to convert to MS as OCB negative patients (hazard ratio = 2.6. The probability to develop MS was even higher when a quantitative intrathecal IgG synthesis was detected (hazard ratio = 3.8. In patients with OCB, VEP did not add further information concerning the conversion rate to MS. In patients with optic neuritis and negative OCB, a significantly higher rate converted to MS when VEP were delayed. In conclusion, the detection of an intrathecal IgG synthesis increases the conversion probability to MS. Pathological VEP can help to predict the conversion rate to MS in patients with optic neuritis without an intrathecal IgG synthesis.
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Lifescience Database Archive (English)
Full Text Available 15802263 Peptidoglycan signaling in innate immunity and inflammatory disease. McDon...ald C, Inohara N, Nunez G. J Biol Chem. 2005 May 27;280(21):20177-80. Epub 2005 Mar 31. (.png) (.svg) (.html) (.csml) Show Peptidog...lycan signaling in innate immunity and inflammatory disease. PubmedID 15802263 Title Peptidog
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2005-02-01
On February 1, 2005, the European Southern Observatory (ESO) has merged its two observatories, La Silla and Paranal, into one. This move will help Europe's prime organisation for astronomy to better manage its many and diverse projects by deploying available resources more efficiently where and when they are needed. The merged observatory will be known as the La Silla Paranal Observatory. Catherine Cesarsky, ESO's Director General, comments the new development: "The merging, which was planned during the past year with the deep involvement of all the staff, has created unified maintenance and engineering (including software, mechanics, electronics and optics) departments across the two sites, further increasing the already very high efficiency of our telescopes. It is my great pleasure to commend the excellent work of Jorge Melnick, former director of the La Silla Observatory, and of Roberto Gilmozzi, the director of Paranal." ESO's headquarters are located in Garching, in the vicinity of Munich (Bavaria, Germany), and this intergovernmental organisation has established itself as a world-leader in astronomy. Created in 1962, ESO is now supported by eleven member states (Belgium, Denmark, Finland, France, Germany, Italy, The Netherlands, Portugal, Sweden, Switzerland, and the United Kingdom). It operates major telescopes on two remote sites, all located in Chile: La Silla, about 600 km north of Santiago and at an altitude of 2400m; Paranal, a 2600m high mountain in the Atacama Desert 120 km south of the coastal city of Antofagasta. Most recently, ESO has started the construction of an observatory at Chajnantor, a 5000m high site, also in the Atacama Desert. La Silla, north of the town of La Serena, has been the bastion of the organization's facilities since 1964. It is the site of two of the most productive 4-m class telescopes in the world, the New Technology Telescope (NTT) - the first major telescope equipped with active optics - and the 3.6-m, which hosts HARPS
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Worldwide R&D of Virtual Observatory
Cui, C. Z.; Zhao, Y. H.
2008-07-01
Virtual Observatory (VO) is a data intensive online astronomical research and education environment, taking advantages of advanced information technologies to achieve seamless and uniform access to astronomical information. The concept of VO was introduced in the late 1990s to meet the challenges brought up with data avalanche in astronomy. In the paper, current status of International Virtual Observatory Alliance, technical highlights from world wide VO projects are reviewed, a brief introduction of Chinese Virtual Observatory is given.
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O evangelho segundo o McDonald's: estudo sobre o processo de produção da fast-food
Alves, Carmen Lucia Rodrigues
2006-01-01
Este estudo aborda o processo de produção da cadeia de fast-food McDonald s, resgatando a forma de produzir seus alimentos, a tecnologia investida, as definições sobre cor, aroma, gosto; as relações de trabalho, desde a estrutura funcional dos trabalhadores, a seleção dos funcionários e o treinamento para cumprir todas as funções que concretizam o processo produtivo. Enfoca, também, através da análise da propaganda de seus produtos, a ideologia que veicula, particularmente p...
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Journal of Astrophysics and Astronomy | Indian Academy of Sciences
Indian Academy of Sciences (India)
2016-01-27
Jan 27, 2016 ... We designed a prime focus CCD photometer, Argos, optimized for high speed time-series measurements of blue variables (Nather & Mukadam 2004) for the 2.1 m telescope at McDonald Observatory. Lack of any intervening optics between the primary mirror and the CCD makes the instrument highly ...
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Inhibitor of differentiation 4 (Id4 is a potential tumor suppressor in prostate cancer
Directory of Open Access Journals (Sweden)
Carey Jason PW
2009-06-01
Full Text Available Abstract Background Inhibitor of differentiation 4 (Id4, a member of the Id gene family is also a dominant negative regulator of basic helix loop helix (bHLH transcription factors. Some of the functions of Id4 appear to be unique as compared to its other family members Id1, Id2 and Id3. Loss of Id4 gene expression in many cancers in association with promoter hypermethylation has led to the proposal that Id4 may act as a tumor suppressor. In this study we provide functional evidence that Id4 indeed acts as a tumor suppressor and is part of a cancer associated epigenetic re-programming. Methods Data mining was used to demonstrate Id4 expression in prostate cancer. Methylation specific polymerase chain reaction (MSP analysis was performed to understand molecular mechanisms associated with Id4 expression in prostate cancer cell lines. The effect of ectopic Id4 expression in DU145 cells was determined by cell cycle analysis (3H thymidine incorporation and FACS, expression of androgen receptor, p53 and cyclin dependent kinase inhibitors p27 and p21 by a combination of RT-PCR, real time-PCR, western blot and immuno-cytochemical analysis. Results Id4 expression was down-regulated in prostate cancer. Id4 expression was also down-regulated in prostate cancer line DU145 due to promoter hyper-methylation. Ectopic Id4 expression in DU145 prostate cancer cell line led to increased apoptosis and decreased cell proliferation due in part by an S-phase arrest. In addition to S-phase arrest, ectopic Id4 expression in PC3 cells also resulted in prolonged G2/M phase. At the molecular level these changes were associated with increased androgen receptor (AR, p21, p27 and p53 expression in DU145 cells. Conclusion The results suggest that Id4 acts directly as a tumor suppressor by influencing a hierarchy of cellular processes at multiple levels that leads to a decreased cell proliferation and change in morphology that is possibly mediated through induction of previously
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Early German plans for southern observatories
Wolfschmidt, G.
2002-07-01
As early as the 18th and 19th centuries, French and English observers were active in South Africa. Around the beginning of the 20th century, Heidelberg and Potsdam astronomers proposed a southern observatory. Then Göttingen astronomers suggested building an observatory in Windhoek for photographing the sky and measuring the solar constant. In 1910 Karl Schwarzschild (1873-1916), after a visit to observatories in the United States, pointed out the usefulness of an observatory in South West Africa, in a climate superior to that in Germany, giving German astronomers access to the southern sky. Seeing tests were begun in 1910 by Potsdam astronomers, but WW I stopped the plans. In 1928 Erwin Finlay-Freundlich (1885-1964), inspired by the Hamburg astronomer Walter Baade (1893-1960), worked out a detailed plan for a southern observatory with a reflecting telescope, spectrographs and an astrograph with an objective prism. Paul Guthnick (1879-1947), director of the Berlin observatory, in cooperation with APO Potsdam and Hamburg, made a site survey to Africa in 1929 and found the conditions in Windhoek to be ideal. Observations were started in the 1930s by Berlin and Breslau astronomers, but were stopped by WW II. In the 1950s, astronomers from Hamburg and The Netherlands renewed the discussion in the framework of European cooperation, and this led to the founding of ESO in 1963.
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ID4 promotes AR expression and blocks tumorigenicity of PC3 prostate cancer cells
International Nuclear Information System (INIS)
Komaragiri, Shravan Kumar; Bostanthirige, Dhanushka H.; Morton, Derrick J.; Patel, Divya; Joshi, Jugal; Upadhyay, Sunil; Chaudhary, Jaideep
2016-01-01
Deregulation of tumor suppressor genes is associated with tumorigenesis and the development of cancer. In prostate cancer, ID4 is epigenetically silenced and acts as a tumor suppressor. In normal prostate epithelial cells, ID4 collaborates with androgen receptor (AR) and p53 to exert its tumor suppressor activity. Previous studies have shown that ID4 promotes tumor suppressive function of AR whereas loss of ID4 results in tumor promoter activity of AR. Previous study from our lab showed that ectopic ID4 expression in DU145 attenuates proliferation and promotes AR expression suggesting that ID4 dependent AR activity is tumor suppressive. In this study, we examined the effect of ectopic expression of ID4 on highly malignant prostate cancer cell, PC3. Here we show that stable overexpression of ID4 in PC3 cells leads to increased apoptosis and decreased cell proliferation and migration. In addition, in vivo studies showed a decrease in tumor size and volume of ID4 overexpressing PC3 cells, in nude mice. At the molecular level, these changes were associated with increased androgen receptor (AR), p21, and AR dependent FKBP51 expression. At the mechanistic level, ID4 may regulate the expression or function of AR through specific but yet unknown AR co-regulators that may determine the final outcome of AR function. - Highlights: • ID4 expression induces AR expression in PC3 cells, which generally lack AR. • ID4 expression increased apoptosis and decreased cell proliferation and invasion. • Overexpression of ID4 reduces tumor growth of subcutaneous xenografts in vivo. • ID4 induces p21 and FKBP51 expression- co-factors of AR tumor suppressor activity.
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ID4 promotes AR expression and blocks tumorigenicity of PC3 prostate cancer cells
Energy Technology Data Exchange (ETDEWEB)
Komaragiri, Shravan Kumar; Bostanthirige, Dhanushka H.; Morton, Derrick J.; Patel, Divya; Joshi, Jugal; Upadhyay, Sunil; Chaudhary, Jaideep, E-mail: jchaudhary@cau.edu
2016-09-09
Deregulation of tumor suppressor genes is associated with tumorigenesis and the development of cancer. In prostate cancer, ID4 is epigenetically silenced and acts as a tumor suppressor. In normal prostate epithelial cells, ID4 collaborates with androgen receptor (AR) and p53 to exert its tumor suppressor activity. Previous studies have shown that ID4 promotes tumor suppressive function of AR whereas loss of ID4 results in tumor promoter activity of AR. Previous study from our lab showed that ectopic ID4 expression in DU145 attenuates proliferation and promotes AR expression suggesting that ID4 dependent AR activity is tumor suppressive. In this study, we examined the effect of ectopic expression of ID4 on highly malignant prostate cancer cell, PC3. Here we show that stable overexpression of ID4 in PC3 cells leads to increased apoptosis and decreased cell proliferation and migration. In addition, in vivo studies showed a decrease in tumor size and volume of ID4 overexpressing PC3 cells, in nude mice. At the molecular level, these changes were associated with increased androgen receptor (AR), p21, and AR dependent FKBP51 expression. At the mechanistic level, ID4 may regulate the expression or function of AR through specific but yet unknown AR co-regulators that may determine the final outcome of AR function. - Highlights: • ID4 expression induces AR expression in PC3 cells, which generally lack AR. • ID4 expression increased apoptosis and decreased cell proliferation and invasion. • Overexpression of ID4 reduces tumor growth of subcutaneous xenografts in vivo. • ID4 induces p21 and FKBP51 expression- co-factors of AR tumor suppressor activity.
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Guinea pig ID-like families of SINEs.
Kass, David H; Schaetz, Brian A; Beitler, Lindsey; Bonney, Kevin M; Jamison, Nicole; Wiesner, Cathy
2009-05-01
Previous studies have indicated a paucity of SINEs within the genomes of the guinea pig and nutria, representatives of the Hystricognathi suborder of rodents. More recent work has shown that the guinea pig genome contains a large number of B1 elements, expanding to various levels among different rodents. In this work we utilized A-B PCR and screened GenBank with sequences from isolated clones to identify potentially uncharacterized SINEs within the guinea pig genome, and identified numerous sequences with a high degree of similarity (>92%) specific to the guinea pig. The presence of A-tails and flanking direct repeats associated with these sequences supported the identification of a full-length SINE, with a consensus sequence notably distinct from other rodent SINEs. Although most similar to the ID SINE, it clearly was not derived from the known ID master gene (BC1), hence we refer to this element as guinea pig ID-like (GPIDL). Using the consensus to screen the guinea pig genomic database (Assembly CavPor2) with Ensembl BlastView, we estimated at least 100,000 copies, which contrasts markedly to just over 100 copies of ID elements. Additionally we provided evidence of recent integrations of GPIDL as two of seven analyzed conserved GPIDL-containing loci demonstrated presence/absence variants in Cavia porcellus and C. aperea. Using intra-IDL PCR and sequence analyses we also provide evidence that GPIDL is derived from a hystricognath-specific SINE family. These results demonstrate that this SINE family continues to contribute to the dynamics of genomes of hystricognath rodents.
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The Self-Identity Protein IdsD Is Communicated between Cells in Swarming Proteus mirabilis Colonies.
Saak, Christina C; Gibbs, Karine A
2016-12-15
Proteus mirabilis is a social bacterium that is capable of self (kin) versus nonself recognition. Swarming colonies of this bacterium expand outward on surfaces to centimeter-scale distances due to the collective motility of individual cells. Colonies of genetically distinct populations remain separate, while those of identical populations merge. Ids proteins are essential for this recognition behavior. Two of these proteins, IdsD and IdsE, encode identity information for each strain. These two proteins bind in vitro in an allele-restrictive manner. IdsD-IdsE binding is correlated with the merging of populations, whereas a lack of binding is correlated with the separation of populations. Key questions remained about the in vivo interactions of IdsD and IdsE, specifically, whether IdsD and IdsE bind within single cells or whether IdsD-IdsE interactions occur across neighboring cells and, if so, which of the two proteins is exchanged. Here we demonstrate that IdsD must originate from another cell to communicate identity and that this nonresident IdsD interacts with IdsE resident in the recipient cell. Furthermore, we show that unbound IdsD in recipient cells does not cause cell death and instead appears to contribute to a restriction in the expansion radius of the swarming colony. We conclude that P. mirabilis communicates IdsD between neighboring cells for nonlethal kin recognition, which suggests that the Ids proteins constitute a type of cell-cell communication. We demonstrate that self (kin) versus nonself recognition in P. mirabilis entails the cell-cell communication of an identity-encoding protein that is exported from one cell and received by another. We further show that this intercellular exchange affects swarm colony expansion in a nonlethal manner, which adds social communication to the list of potential swarm-related regulatory factors. Copyright © 2016, American Society for Microbiology. All Rights Reserved.
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Événement, idéologie et utopie
Directory of Open Access Journals (Sweden)
Jean-Luc AMALRIC
2014-12-01
Full Text Available RESUMEL’hypothèse que tente d’esquisser cet article est que l’idée ricœurienne d’une médiatisation dynamique des contradictions de l’imaginaire social présuppose une corrélation originaire de l’idéologie et de l’utopie qui ne peut elle-même être comprise qu’à partir de l’événement de l’institution d’un imaginaire social constituant. Dans un premier temps, l’article s’efforce de cerner ce qui fait la spécificité de la théorie ricœurienne de l’idéologie et de l’utopie comme « pratiques imaginatives », en soulignant à ce titre l’influence déterminante des thèses de Jacques Ellul sur l’idéologie. Puis, dans un second temps, il s’engage dans une analyse régressive qui conduit de la réappropriation ricœurienne de la conception dialectique de l’idéologie et de l’utopie exposée par Mannheim à l’idée d’un fondement événementiel de ces deux formes opposées de l’imaginaire social.Mots-Clés : Evénement, idéologie, utopie, Ellul, Mannheim. ABSTRACTThis paper attempts to sketch out the hypothesis that the Ricœurian conception of a dynamic mediatization of the contradictions of the social imaginary presupposes an original correlation between ideology and utopia, which can itself be understood only from the event that institutes a constitutive social imaginary. The first part of the paper marks out the specificity of the Ricœurian theory of ideology and utopia in terms of “imaginative practices”, underlining the determining influence of Jacques Ellul’s theses on ideology. The second part tries to develop a regressive argument, starting from the Ricœurian re-appropriation of Mannheim’s dialectical conception of ideology and utopia, and leading back to the idea of an event foundation for these two opposed forms of the social imaginary.Keywords : Event, Ideology, Utopia, Ellul, Mannheim
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The Malaysian Robotic Solar Observatory (P29)
Othman, M.; Asillam, M. F.; Ismail, M. K. H.
2006-11-01
Robotic observatory with small telescopes can make significant contributions to astronomy observation. They provide an encouraging environment for astronomers to focus on data analysis and research while at the same time reducing time and cost for observation. The observatory will house the primary 50cm robotic telescope in the main dome which will be used for photometry, spectroscopy and astrometry observation activities. The secondary telescope is a robotic multi-apochromatic refractor (maximum diameter: 15 cm) which will be housed in the smaller dome. This telescope set will be used for solar observation mainly in three different wavelengths simultaneously: the Continuum, H-Alpha and Calcium K-line. The observatory is also equipped with an automated weather station, cloud & rain sensor and all-sky camera to monitor the climatic condition, sense the clouds (before raining) as well as to view real time sky view above the observatory. In conjunction with the Langkawi All-Sky Camera, the observatory website will also display images from the Malaysia - Antarctica All-Sky Camera used to monitor the sky at Scott Base Antarctica. Both all-sky images can be displayed simultaneously to show the difference between the equatorial and Antarctica skies. This paper will describe the Malaysian Robotic Observatory including the systems available and method of access by other astronomers. We will also suggest possible collaboration with other observatories in this region.
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Regulation of Id2 expression in EL4 T lymphoma cells overexpressing growth hormone.
Weigent, Douglas A
2009-01-01
In previous studies, we have shown that overexpression of growth hormone (GH) in cells of the immune system upregulates proteins involved in cell growth and protects from apoptosis. Here, we report that overexpression of GH in EL4 T lymphoma cells (GHo) also significantly increased levels of the inhibitor of differentiation-2 (Id2). The increase in Id2 was suggested in both Id2 promoter luciferase assays and by Western analysis for Id2 protein. To identify the regulatory elements that mediate transcriptional activation by GH in the Id2 promoter, promoter deletion analysis was performed. Deletion analysis revealed that transactivation involved a 301-132bp region upstream to the Id2 transcriptional start site. The pattern in the human GHo Jurkat T lymphoma cell line paralleled that found in the mouse GHo EL4 T lymphoma cell line. Significantly less Id2 was detected in the nucleus of GHo EL4 T lymphoma cells compared to vector alone controls. Although serum increased the levels of Id2 in control vector alone cells, no difference was found in the total levels of Id2 in GHo EL4 T lymphoma cells treated with or without serum. The increase in Id2 expression in GHo EL4 T lymphoma cells measured by Id2 promoter luciferase expression and Western blot analysis was blocked by the overexpression of a dominant-negative mutant of STAT5. The results suggest that in EL4 T lymphoma cells overexpressing GH, there is an upregulation of Id2 protein that appears to involve STAT protein activity.
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Best practices for the implementation of the REAL ID Act.
2015-10-01
The REAL ID Act specifies the minimum standards that must be used to produce and issue drivers license and : identification cards that are REAL ID compliant. Beginning in 2020, if a person does not possess a form of : identification that meets REA...
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The Fram Strait integrated ocean observatory
Fahrbach, E.; Beszczynska-Möller, A.; Rettig, S.; Rohardt, G.; Sagen, H.; Sandven, S.; Hansen, E.
2012-04-01
A long-term oceanographic moored array has been operated since 1997 to measure the ocean water column properties and oceanic advective fluxes through Fram Strait. While the mooring line along 78°50'N is devoted to monitoring variability of the physical environment, the AWI Hausgarten observatory, located north of it, focuses on ecosystem properties and benthic biology. Under the EU DAMOCLES and ACOBAR projects, the oceanographic observatory has been extended towards the innovative integrated observing system, combining the deep ocean moorings, multipurpose acoustic system and a network of gliders. The main aim of this system is long-term environmental monitoring in Fram Strait, combining satellite data, acoustic tomography, oceanographic measurements at moorings and glider sections with high-resolution ice-ocean circulation models through data assimilation. In future perspective, a cable connection between the Hausgarten observatory and a land base on Svalbard is planned as the implementation of the ESONET Arctic node. To take advantage of the planned cabled node, different technologies for the underwater data transmission were reviewed and partially tested under the ESONET DM AOEM. The main focus was to design and evaluate available technical solutions for collecting data from different components of the Fram Strait ocean observing system, and an integration of available data streams for the optimal delivery to the future cabled node. The main components of the Fram Strait integrated observing system will be presented and the current status of available technologies for underwater data transfer will be reviewed. On the long term, an initiative of Helmholtz observatories foresees the interdisciplinary Earth-Observing-System FRAM which combines observatories such as the long term deep-sea ecological observatory HAUSGARTEN, the oceanographic Fram Strait integrated observing system and the Svalbard coastal stations maintained by the Norwegian ARCTOS network. A vision
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ID card number detection algorithm based on convolutional neural network
Zhu, Jian; Ma, Hanjie; Feng, Jie; Dai, Leiyan
2018-04-01
In this paper, a new detection algorithm based on Convolutional Neural Network is presented in order to realize the fast and convenient ID information extraction in multiple scenarios. The algorithm uses the mobile device equipped with Android operating system to locate and extract the ID number; Use the special color distribution of the ID card, select the appropriate channel component; Use the image threshold segmentation, noise processing and morphological processing to take the binary processing for image; At the same time, the image rotation and projection method are used for horizontal correction when image was tilting; Finally, the single character is extracted by the projection method, and recognized by using Convolutional Neural Network. Through test shows that, A single ID number image from the extraction to the identification time is about 80ms, the accuracy rate is about 99%, It can be applied to the actual production and living environment.
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Armstrong, F E
2003-01-01
Two Queen's University researchers are among three Canadian finalists in a contest to win $1 million. Art McDonald, director of the Queen's-run Sudbury Neutrino Observatory Institute, and John Smol, Canada Research Chair in Environmental Change, have been nominated for the Gerhard Herzberg Canada Gold Medal for Science and Engineering (1 page).
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REFORMASI PEMAHAMAN TEORI MAQᾹṢID SYARIAH Analisis Pendekatan Sistem Jasser Auda
Directory of Open Access Journals (Sweden)
Muhammad Iqbal Fasa
2016-12-01
Full Text Available This paper attempts to offer reform ideas Jasser Auda thought related reforms theoretical understanding of maqᾱṣid sharia. The systems approach is done by Auda critize the theory of classical maqᾱṣid more likely to hierarchical and narrow mindset. The classical maqᾱṣid pressure a point more on protection and preservation. Whereas the new maqᾱṣid theory emphasizes development (construction, development and rights (rights. Thus, Auda developed the concept of human development as the main target of maslahah (public interest. Auda offers the systems approach, namely: cognitive nature; interrelated; wholeness; openness; multi dimentionality and purposefulness. At the end of the discussion in this paper, the authors develop the idea of Jasser Auda by offering Sharia Maqᾱṣid concept in the context of Islamic Economics
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Interoperability for electronic ID
Zygadlo, Zuzanna
2009-01-01
Electronic Business, including eBanking, eCommerce and eGovernmental services, is today based on a large variety of security solutions, comprising electronic IDs provided by a broad community of Public Key Infrastructure (PKI) vendors. Significant differences in implementations of those solutions introduce a problem of lack of interoperability in electronic business, which have not yet been resolved by standardization and interoperability initiatives based on existing PKI trust models. It i...
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195-Year History of Mykolayiv Observatory: Events and People
Directory of Open Access Journals (Sweden)
Shulga, O.V.
2017-01-01
Full Text Available The basic stages of the history of the Mykolaiv Astronomical Observatory are shown. The main results of the Observatory activities are presented by the catalogs of star positions, major and minor planets in the Solar system, space objects in the Earth orbit. The information on the qualitative and quantitative structure of the Observatory, cooperation with the observatories of Ukraine and foreign countries as well as major projects carried out in the Observatory is provided.
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Avar, Z; Tóth, B; Zacher, P
1979-01-01
Authors have performed the McDonald cerclage operation on 172 gravidae because of cervical incompetence. From these pregnancies 80.2 per cent of the infants have survived over the sixth day. While with operations performed on the basis of extended indications for surgery an effect of 56.5 per cent was achieved, it was in cases of classical ones 92.8 per cent. Two complicated cases are reported caused by blastospores or bacteria respectively, isolated also in the vaginal secretion which have ascended into the uterine cavity. Both cases resulted in fetal death and in a septic condition of the mother. It is emphasized that the normal vaginal bioflora is essential condition for the cervical suture.
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Psychometrics and latent structure of the IDS and QIDS with young adult students.
González, David Andrés; Boals, Adriel; Jenkins, Sharon Rae; Schuler, Eric R; Taylor, Daniel
2013-07-01
Students and young adults have high rates of suicide and depression, thus are a population of interest. To date, there is no normative psychometric information on the IDS and QIDS in these populations. Furthermore, there is equivocal evidence on the factor structure and subscales of the IDS. Two samples of young adult students (ns=475 and 1681) were given multiple measures to test the psychometrics and dimensionality of the IDS and QIDS. The IDS, its subscales, and QIDS had acceptable internal consistencies (αs=.79-90) and favorable convergent and divergent validity correlations. A three-factor structure and two Rasch-derived subscales best fit the IDS. The samples were collected from one university, which may influence generalizability. The IDS and QIDS are desirable measures of depressive symptoms when studying young adult students. Copyright © 2013 Elsevier B.V. All rights reserved.
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78 FR 65555 - Establishment of Class E Airspace; Salmon, ID
2013-11-01
...-0531; Airspace Docket No. 13-ANM-20] Establishment of Class E Airspace; Salmon, ID AGENCY: Federal... at the Salmon VHF Omni-Directional Radio Range/Distance Measuring Equipment (VOR/DME) navigation aid, Salmon, ID, to facilitate vectoring of Instrument Flight Rules (IFR) aircraft under control of Salt Lake...
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CASK inhibits ECV304 cell growth and interacts with Id1
International Nuclear Information System (INIS)
Qi Jie; Su Yongyue; Sun Rongju; Zhang Fang; Luo Xiaofeng; Yang Zongcheng; Luo Xiangdong
2005-01-01
Calcium/calmodulin-dependent serine protein kinase (CASK) is generally known as a scaffold protein. Here we show that overexpression of CASK resulted in a reduced rate of cell growth, while inhibition of expression of endogenous CASK via RNA-mediated interference resulted in an increased rate of cell growth in ECV304 cells. To explore the molecular mechanism, we identified a novel CASK-interacting protein, inhibitor of differentiation 1 (Id1) with a yeast two-hybrid screening. Furthermore, endogenous CASK and Id1 proteins were co-precipitated from the lysates of ECV304 cells by immunoprecipitation. Mammalian two-hybrid protein-protein interaction assays indicated that CASK possessed a different binding activity for Id1 and its alternative splicing variant. It is known that Id proteins play important roles in regulation of cell proliferation and differentiation. Thus, we speculate that the regulation of cell growth mediated by CASK may be involved in Id1. Our findings indicate a novel function of CASK, the mechanism that remains to be further investigated
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Brecher, K.; Sadler, P.
1994-12-01
A group of scientists, engineers and educators based at the Harvard-Smithsonian Center for Astrophysics (CfA) has developed a prototype of a small, inexpensive and fully integrated automated astronomical telescope and image processing system. The project team is now building five second generation instruments. The MicroObservatory has been designed to be used for classroom instruction by teachers as well as for original scientific research projects by students. Probably in no other area of frontier science is it possible for a broad spectrum of students (not just the gifted) to have access to state-of-the-art technologies that would allow for original research. The MicroObservatory combines the imaging power of a cooled CCD, with a self contained and weatherized reflecting optical telescope and mount. A microcomputer points the telescope and processes the captured images. The MicroObservatory has also been designed to be used as a valuable new capture and display device for real time astronomical imaging in planetariums and science museums. When the new instruments are completed in the next few months, they will be tried with high school students and teachers, as well as with museum groups. We are now planning to make the MicroObservatories available to students, teachers and other individual users over the Internet. We plan to allow the telescope to be controlled in real time or in batch mode, from a Macintosh or PC compatible computer. In the real-time mode, we hope to give individual access to all of the telescope control functions without the need for an "on-site" operator. Users would sign up for a specific period of time. In the batch mode, users would submit jobs for the telescope. After the MicroObservatory completed a specific job, the images would be e-mailed back to the user. At present, we are interested in gaining answers to the following questions: (1) What are the best approaches to scheduling real-time observations? (2) What criteria should be used
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The Astrophysical Multimessenger Observatory Network (AMON)
Smith. M. W. E.; Fox, D. B.; Cowen, D. F.; Meszaros, P.; Tesic, G.; Fixelle, J.; Bartos, I.; Sommers, P.; Ashtekar, Abhay; Babu, G. Jogesh;
2013-01-01
We summarize the science opportunity, design elements, current and projected partner observatories, and anticipated science returns of the Astrophysical Multimessenger Observatory Network (AMON). AMON will link multiple current and future high-energy, multimessenger, and follow-up observatories together into a single network, enabling near real-time coincidence searches for multimessenger astrophysical transients and their electromagnetic counterparts. Candidate and high-confidence multimessenger transient events will be identified, characterized, and distributed as AMON alerts within the network and to interested external observers, leading to follow-up observations across the electromagnetic spectrum. In this way, AMON aims to evoke the discovery of multimessenger transients from within observatory subthreshold data streams and facilitate the exploitation of these transients for purposes of astronomy and fundamental physics. As a central hub of global multimessenger science, AMON will also enable cross-collaboration analyses of archival datasets in search of rare or exotic astrophysical phenomena.
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Early German Plans for a Southern Observatory
Wolfschmidt, Gudrun
As early as the 18th and 19th centuries, French and English observers were active in South Africa. Around the beginning of the 20th century the Heidelberg astronomer Max Wolf (1863-1932) proposed a southern observatory. In 1907 Hermann Carl Vogel (1841-1907), director of the Astrophysical Observatory Potsdam, suggested a southern station in Spain. His ideas for building an observatory in Windhuk for photographing the sky and measuring the solar constant were taken over by the Göttingen astronomers. In 1910 Karl Schwarzschild (1873-1916), after having visited the observatories in America, pointed out the usefulness of an observatory in South West Africa, where it would have better weather than in Germany and also give access to the southern sky. Seeing tests were begun in 1910 by Potsdam astronomers, but WW I stopped the plans. In 1928 Erwin Finlay-Freundlich (1885-1964), inspired by the Hamburg astronomer Walter Baade (1893-1960), worked out a detailed plan for a southern observatory with a reflecting telescope, spectrographs and an astrograph with an objective prism. Paul Guthnick (1879-1947), director of the Berlin observatory, in cooperation with APO Potsdam and Hamburg, made a site survey to Africa in 1929 and found the conditions in Windhuk to be ideal. Observations were started in the 1930s by Berlin and Breslau astronomers, but were stopped by WW II. In the 1950s, astronomers from Hamburg and The Netherlands renewed the discussion in the framework of European cooperation, and this led to the founding of ESO in 1963, as is well described by Blaauw (1991). Blaauw, Adriaan: ESO's Early History. The European Southern Observatory from Concept to Reality. Garching bei München: ESO 1991.
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A Green Robotic Observatory for Astronomy Education
Reddy, Vishnu; Archer, K.
2008-09-01
With the development of robotic telescopes and stable remote observing software, it is currently possible for a small institution to have an affordable astronomical facility for astronomy education. However, a faculty member has to deal with the light pollution (observatory location on campus), its nightly operations and regular maintenance apart from his day time teaching and research responsibilities. While building an observatory at a remote location is a solution, the cost of constructing and operating such a facility, not to mention the environmental impact, are beyond the reach of most institutions. In an effort to resolve these issues we have developed a robotic remote observatory that can be operated via the internet from anywhere in the world, has a zero operating carbon footprint and minimum impact on the local environment. The prototype observatory is a clam-shell design that houses an 8-inch telescope with a SBIG ST-10 CCD detector. The brain of the observatory is a low draw 12-volt harsh duty computer that runs the dome, telescope, CCD camera, focuser, and weather monitoring. All equipment runs of a 12-volt AGM-style battery that has low lead content and hence more environmental-friendly to dispose. The total power of 12-14 amp/hrs is generated from a set of solar panels that are large enough to maintain a full battery charge for several cloudy days. This completely eliminates the need for a local power grid for operations. Internet access is accomplished via a high-speed cell phone broadband connection or satellite link eliminating the need for a phone network. An independent observatory monitoring system interfaces with the observatory computer during operation. The observatory converts to a trailer for transportation to the site and is converted to a semi-permanent building without wheels and towing equipment. This ensures minimal disturbance to local environment.
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Texas-style Fundraising and Public Relations for the International Year of Astronomy
Preston, Sandra; Barna, J. W.; Geiger, S.; Johnson, R.; Rimm, N.; Griffin, J.; Watson, K.
2008-05-01
McDonald Observatory can be a leader in Texas for the International Year of Astronomy (IYA09) celebration. Our strategy builds on the IYA09 program, tailoring it for the Texas audience, while also nationally promoting McDonald Observatory, UT Astronomy, the Hobby-Eberly Telescope Dark Energy Experiment (HETDEX) and our partnership in the Giant Magellan Telescope (GMT). We will also use this opportunity to make a concentrated outreach effort toward the Hispanic and Spanish-speaking communities in Texas and the nation, aligning with the IYA09 objective for improving relations with underrepresented and minority populations. Fundraising is a key ingredient to our success in 2009 and the future. With NASA Office of Space Science funding for education and public outreach being rethought, we will be focusing on new sources for fundraising, including private donations and corporate sponsorship, augmented by planned giving. We will take advantage of the timing to raise funds for special IYA09 programs, as well as for our large telescope projects HETDEX and GMT, along with our endowment and planned giving programs for education, outreach, and research. We will work with the UT McCombs School of Business on corporate sponsorship. During this time we will also go through a branding experience that will visually unify McDonald Observatory, UT Astronomy, and the education and public outreach programs. A consistent brand that can be used on the website and other media is our goal to build a stronger public presence that will aid us in our fundraising efforts. A Public Relations Internship Project produced a report to help launch this process. We are working with the UT College of Communications Advertising Department and with Hill Strategic Brand Solutions in Houston, Texas. We hope that our efforts will produce Texas-sized results!
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idRHa+ProMod - Rail Hardening Control System
International Nuclear Information System (INIS)
Ferro, L
2016-01-01
idRHa+ProMod is the process control system developed by Primetals Technologies to foresee the thermo-mechanical evolution and micro-structural composition of rail steels subjected to slack quenching into idRHa+ Rail Hardening equipments in a simulation environment. This tool can be used both off-line or in-line, giving the user the chance to test and study the best cooling strategies or letting the automatic control system free to adjust the proper cooling recipe. Optimization criteria have been tailored in order to determine the best cooling conditions according to the metallurgical requirements imposed by the main rail standards and also taking into account the elastoplastic bending phenomena occurring during all stages of the head hardening process. The computational core of idRHa+ProMod is a thermal finite element procedure coupled with special algorithms developed to work out the main thermo-physical properties of steel, to predict the non-isothermal austenite decomposition into all the relevant phases and subsequently to evaluate the amount of latent heat of transformation released, the compound thermal expansion coefficient and the amount of plastic deformation in the material. Air mist and air blades boundary conditions have been carefully investigated by means of pilot plant tests aimed to study the jet impingement on rail surfaces and the cooling efficiency at all working conditions. Heat transfer coefficients have been further checked and adjusted directly on field during commissioning. idRHa+ is a trademark of Primetals Technologies Italy Srl (paper)
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idRHa+ProMod - Rail Hardening Control System
Ferro, L.
2016-03-01
idRHa+ProMod is the process control system developed by Primetals Technologies to foresee the thermo-mechanical evolution and micro-structural composition of rail steels subjected to slack quenching into idRHa+ Rail Hardening equipments in a simulation environment. This tool can be used both off-line or in-line, giving the user the chance to test and study the best cooling strategies or letting the automatic control system free to adjust the proper cooling recipe. Optimization criteria have been tailored in order to determine the best cooling conditions according to the metallurgical requirements imposed by the main rail standards and also taking into account the elastoplastic bending phenomena occurring during all stages of the head hardening process. The computational core of idRHa+ProMod is a thermal finite element procedure coupled with special algorithms developed to work out the main thermo-physical properties of steel, to predict the non-isothermal austenite decomposition into all the relevant phases and subsequently to evaluate the amount of latent heat of transformation released, the compound thermal expansion coefficient and the amount of plastic deformation in the material. Air mist and air blades boundary conditions have been carefully investigated by means of pilot plant tests aimed to study the jet impingement on rail surfaces and the cooling efficiency at all working conditions. Heat transfer coefficients have been further checked and adjusted directly on field during commissioning. idRHa+ is a trademark of Primetals Technologies Italy Srl
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ID Barrel installed in cryostat
Apsimon, R.; Romaniouk, A.
Wednesday 23rd August was a memorable day for the Inner Detector community as they witnessed the transport and installation of the central part of the inner detector (ID-barrel) into the ATLAS detector. Many members of the collaboration gathered to witness this moment at Point 1. After years of design, construction and commissioning, the outer two detectors (TRT and SCT) of the ID barrel were moved from the SR1 cleanroom to the ATLAS cavern. The barrel was moved across the car park from building 2175 to SX1. Although only a journey of about 100 metres, this required weeks of planning and some degree of luck as far as the weather was concerned. Accelerometers were fitted to the barrel to provide real-time monitoring and no values greater than 0.1 g were recorded, fully satisfying the transport specification for this extremely precise and fragile detector. Muriel, despite her fear of heights, bravely volunteered to keep a close eye on the detector. Swapping cranes to cross the entire parking lot, while Mur...
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Proces zavádění nových výrobků společnosti McDonald ´s
Vaňková, Kateřina
2010-01-01
This Bachelor's thesis focuses on the way of introducing new products of the company McDonald's in the Czech Republic. It is divided into theoretical and practical part. The theoretical part of the thesis deals the fundamental terms of general marketing. These are: SWOT analysis, marketing communications, marketing strategies and communication mix. In the practical part of the thesis is presented the history of the company, the corporate social responsibility and the basic principles. The fol...
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TENCompetence Competence Observatory
Vervenne, Luk
2010-01-01
Vervenne, L. (2007) TENCompetence Competence Observatory. Sources available http://tencompetence.cvs.sourceforge.net/viewvc/tencompetence/wp8/org.tencompetence.co/. Available under the three clause BSD license, copyright TENCompetence Foundation.
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The Farid and Moussa Raphael Observatory
International Nuclear Information System (INIS)
Hajjar, R
2017-01-01
The Farid and Moussa Raphael Observatory (FMRO) at Notre Dame University Louaize (NDU) is a teaching, research, and outreach facility located at the main campus of the university. It located very close to the Lebanese coast, in an urbanized area. It features a 60-cm Planewave CDK telescope, and instruments that allow for photometric and spetroscopic studies. The observatory currently has one thinned, back-illuminated CCD camera, used as the main imager along with Johnson-Cousin and Sloan photometric filters. It also features two spectrographs, one of which is a fiber fed echelle spectrograph. These are used with a dedicated CCD. The observatory has served for student projects, and summer schools for advanced undergraduate and graduate students. It is also made available for use by the regional and international community. The control system is currently being configured for remote observations. A number of long-term research projects are also being launched at the observatory. (paper)
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ID.alistic: identificatie met een touch voor de patiënt
M. Wilschut; M. Zijlmans; Dr. L.S.G.L Wauben
2017-01-01
ID.alistic is een conceptuele patiëntidentificatie methode (middels een vingerafdrukscanner), ter vervanging van het polsbandjessysteem van het Albert Schweitzer ziekenhuis (ASz) dialysecentrum. Dit onderzoek bepaalt de implementeerbaarheid van ID.alistic binnen het dialysecentrum door
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DEFF Research Database (Denmark)
Babakhanyan, Anna; Leke, Rose G F; Salanti, Ali
2014-01-01
In pregnant women, Plasmodium falciparum-infected erythrocytes expressing the VAR2CSA antigen bind to chondroitin sulfate A in the placenta causing placental malaria. The binding site of VAR2CSA is present in the ID1-ID2a region. This study sought to determine if pregnant Cameroonian women natura...
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Internal validation of the RapidHIT® ID system.
Wiley, Rachel; Sage, Kelly; LaRue, Bobby; Budowle, Bruce
2017-11-01
Traditionally, forensic DNA analysis has required highly skilled forensic geneticists in a dedicated laboratory to generate short tandem repeat (STR) profiles. STR profiles are routinely used either to associate or exclude potential donors of forensic biological evidence. The typing of forensic reference samples has become more demanding, especially with the requirement in some jurisdictions to DNA profile arrestees. The Rapid DNA (RDNA) platform, the RapidHIT ® ID (IntegenX ® , Pleasanton, CA), is a fully automated system capable of processing reference samples in approximately 90min with minimal human intervention. Thus, the RapidHIT ID instrument can be deployed to non-laboratory environments (e.g., booking stations) and run by trained atypical personnel such as law enforcement. In order to implement the RapidHIT ID platform, validation studies are needed to define the performance and limitations of the system. Internal validation studies were undertaken with four early-production RapidHIT ID units. Reliable and concordant STR profiles were obtained from reference buccal swabs. Throughout the study, no contamination was observed. The overall first-pass success rate with an "expert-like system" was 72%, which is comparable to another current RDNA platform commercially available. The system's second-pass success rate (involving manual interpretation on first-pass inconclusive results) increased to 90%. Inhibitors (i.e., coffee, smoking tobacco, and chewing tobacco) did not appear to affect typing by the instrument system; however, substrate (i.e., swab type) did impact typing success. Additionally, one desirable feature not available with other Rapid systems is that in the event of a system failed run, a swab can be recovered and subsequently re-analyzed in a new sample cartridge. Therefore, rarely should additional sampling or swab consumption be necessary. The RapidHIT ID system is a robust and reliable tool capable of generating complete STR profiles within
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Electricity and gas market observatory. 2. Quarter 2007
International Nuclear Information System (INIS)
2007-01-01
The purpose of the observatory is to provide the general public with indicators for monitoring market deregulation. It both covers the wholesale and retail electricity and gas markets in Metropolitan France. This observatory is updated every three months and data are available on CRE web site (www.cre.fr). The present observatory is dedicated only to eligible customers before 1 July 2007, i.e. non-residential customers. Statistics related to residential customers will be published in the next observatory (1 December 2007). Content: A - The electricity market: The retail electricity market (Introduction, Non-residential customer segments and their respective weights, Status at July 1, 2007, Dynamic analysis: 2. Quarter 2007); The wholesale electricity market (Introduction, Wholesale market activity in France, Wholesale market activity in France, Prices on the French wholesale market and European comparison, Import and export volumes, Concentration of the French electricity market, Striking fact of the second quarter 2007); B - The gas market: The retail gas market (Introduction, The non-residential customer segments and their respective weights, Status at July 1, 2007); The wholesale gas market (Gas pricing and gas markets in Europe, The wholesale market in France); C - Appendices: Electricity and gas market observatories combined glossary, Specific electricity market observatory glossary, Specific gas market observatory glossary
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Bio-fortification and shelf-life extension of idli batter using curry leaves (Murraya koenigii).
Chelliah, R; Ramakrishnan, S R; Premkumar, D; Antony, U
2016-06-01
Among several traditional foods of India, idli is one of the most popular and commonly consumed steamed products. A new method of adding Murraya koenigii (curry leaves) to idli batter as a vehicle for fortification and extension of shelf-life has been developed. Dried curry leaves powder was incorporated with other ingredients like rice and dehusked black gram in different proportions to optimize the most palatable formulation. Rate of fermentation and microbial changes in the batter; nutritional qualities, texture and sensory properties of the prepared product were assessed. Incorporation of curry leaves powder (5 %) in idli batter increased the shelf-life and also increased the flavour, texture and appearance of the idli. The calcium content of the prepared idli was 10 times more than that of the control idli, while dietary fiber content increased by 18.6 %. Anti-microbial activity of the curry leaves in idli batter extended the shelf-life from 2 to 5 days when stored at 30 °C.
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To ID or Not to ID? Changes in Classification Rates of Intellectual Disability Using "DSM-5"
Papazoglou, Aimilia; Jacobson, Lisa A.; McCabe, Marie; Kaufmann, Walter; Zabel, T. Andrew
2014-01-01
The "Diagnostic and Statistical Manual of Mental Disorders-Fifth Edition" ("DSM-5") diagnostic criteria for intellectual disability (ID) include a change to the definition of adaptive impairment. New criteria require impairment in one adaptive domain rather than two or more skill areas. The authors examined the diagnostic…
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1991-01-01
This photograph shows the Compton Gamma-Ray Observatory (GRO) being deployed by the Remote Manipulator System (RMS) arm aboard the Space Shuttle Atlantis during the STS-37 mission in April 1991. The GRO reentered Earth atmosphere and ended its successful mission in June 2000. For nearly 9 years, the GRO Burst and Transient Source Experiment (BATSE), designed and built by the Marshall Space Flight Center (MSFC), kept an unblinking watch on the universe to alert scientists to the invisible, mysterious gamma-ray bursts that had puzzled them for decades. By studying gamma-rays from objects like black holes, pulsars, quasars, neutron stars, and other exotic objects, scientists could discover clues to the birth, evolution, and death of stars, galaxies, and the universe. The gamma-ray instrument was one of four major science instruments aboard the Compton. It consisted of eight detectors, or modules, located at each corner of the rectangular satellite to simultaneously scan the entire universe for bursts of gamma-rays ranging in duration from fractions of a second to minutes. In January 1999, the instrument, via the Internet, cued a computer-controlled telescope at Las Alamos National Laboratory in Los Alamos, New Mexico, within 20 seconds of registering a burst. With this capability, the gamma-ray experiment came to serve as a gamma-ray burst alert for the Hubble Space Telescope, the Chandra X-Ray Observatory, and major gound-based observatories around the world. Thirty-seven universities, observatories, and NASA centers in 19 states, and 11 more institutions in Europe and Russia, participated in the BATSE science program.
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Space astrophysical observatory 'Orion-2'
International Nuclear Information System (INIS)
Gurzadyan, G.A.; Jarakyan, A.L.; Krmoyan, M.N.; Kashin, A.L.; Loretsyan, G.M.; Ohanesyan, J.B.
1976-01-01
Ultraviolet spectrograms of a large number of faint stars up to 13sup(m) were obtained in the wavelengths 2000-5000 A by means of the space observatory 'Orion-2' installed in the spaceship 'Soyuz-13' with two spacemen on board. The paper deals with a description of the operation modes of this observatory, the designs and basic schemes of the scientific and auxiliary device and the method of combining the work of the flight engineer and the automation system of the observatory itself. It also treats of the combination of the particular parts of 'Orion-2' observatory on board the spaceship and the measures taken to provide for its normal functioning in terms of the space flight. A detailed description is given of the optical, electrical and mechanical schemes of the devices - meniscus telescope with an objective prism, stellar diffraction spectrographs, single-coordinate and two-coordinate stellar and solar transducers, control panel, control systems, etc. The paper also provides the functional scheme of astronavigation, six-wheel stabilization, the design of mounting (assembling) the stabilized platform carrying the telescopes and the drives used in it. Problems relating to the observation program in orbit, the ballistic provision of initial data, and control of the operation of the observatory are also dealt with. In addition, the paper carries information of the photomaterials used, the methods of their energy calibration, standardization and the like. Matters of pre-start tests of apparatus, the preparation of the spacemen for conducting astronomical observations with the given devices, etc. are likewise dwelt on. The paper ends with a brief survey of the results obtained and the elaboration of the observed material. (Auth.)
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ACE I/D genotype, adiposity, and blood pressure in children
Directory of Open Access Journals (Sweden)
Rothschild Max
2009-03-01
Full Text Available Abstract Background Angiotensin converting enzyme (ACE is a possible candidate gene that may influence both body fatness and blood pressure. Although several genetic studies have been conducted in adults, relatively few studies have examined the contribution of potential candidate genes, and specifically ACE I/D, on adiposity and BP phenotypes in childhood. Such studies may prove insightful for the development of the obesity-hypertension phenotype early in life. The purpose of this study was to examine differences in body fatness and resting blood pressure (BP by ACE I/D genotype, and determine if the association between adiposity and BP varies by ACE I/D genotype in children. Methods 152 children (75 girls, 77 boys were assessed for body composition (% body fat using dual energy x-ray absorbtiometry and resting BP according to American Heart Association recommendations. Buccal cell samples were genotyped using newly developed PCR-RFLP tests for two SNPs (rs4341 and rs4343 in complete linkage disequilibrium with the ACE I/D polymorphism. Partial correlations were computed to assess the ociations between % body fat and BP in the total sample and by genotype. ANCOVA was used to examine differences in resting BP by ACE I/D genotype and fatness groups. Results Approximately 39% of youth were overfat based on % body fat (>30% fat in girls, 25% fat in boys. Body mass, body mass index, and fat-free mass were significantly higher in the ACE D-carriers compared to the II group (p Conclusion ACE D-carriers are heavier than ACE II children; however, BP did not differ by ACE I/D genotype but was adversely influenced in the overfat D-carriers. Further studies are warranted to investigate the genetics of fatness and BP phenotypes in children.
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The University of Montana's Blue Mountain Observatory
Friend, D. B.
2004-12-01
The University of Montana's Department of Physics and Astronomy runs the state of Montana's only professional astronomical observatory. The Observatory, located on nearby Blue Mountain, houses a 16 inch Boller and Chivens Cassegrain reflector (purchased in 1970), in an Ash dome. The Observatory sits just below the summit ridge, at an elevation of approximately 6300 feet. Our instrumentation includes an Op-Tec SSP-5A photoelectric photometer and an SBIG ST-9E CCD camera. We have the only undergraduate astronomy major in the state (technically a physics major with an astronomy option), so our Observatory is an important component of our students' education. Students have recently carried out observing projects on the photometry of variable stars and color photometry of open clusters and OB associations. In my poster I will show some of the data collected by students in their observing projects. The Observatory is also used for public open houses during the summer months, and these have become very popular: at times we have had 300 visitors in a single night.
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Robotic Software for the Thacher Observatory
Lawrence, George; Luebbers, Julien; Eastman, Jason D.; Johnson, John A.; Swift, Jonathan
2018-06-01
The Thacher Observatory—a research and educational facility located in Ojai, CA—uses a 0.7 meter telescope to conduct photometric research on a variety of targets including eclipsing binaries, exoplanet transits, and supernovae. Currently, observations are automated using commercial software. In order to expand the flexibility for specialized scientific observations and to increase the educational value of the facility on campus, we are adapting and implementing the custom observatory control software and queue scheduling developed for the Miniature Exoplanet Radial Velocity Array (MINERVA) to the Thacher Observatory. We present the design and implementation of this new software as well as its demonstrated functionality on the Thacher Observatory.
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Id3 induces an Elk-1–caspase-8-dependent apoptotic pathway in squamous carcinoma cells
International Nuclear Information System (INIS)
Chen, You-Shin; Aubee, Joseph; DiVito, Kyle A; Zhou, Hengbo; Zhang, Weiyi; Chou, Fen-Pi; Simbulan-Rosenthal, Cynthia M; Rosenthal, Dean S
2015-01-01
Inhibitor of differentiation/DNA-binding (Id) proteins are helix–loop–helix (HLH) transcription factors. The Id protein family (Id1–Id4) mediates tissue homeostasis by regulating cellular processes including differentiation, proliferation, and apoptosis. Ids typically function as dominant negative HLH proteins, which bind other HLH proteins and sequester them away from DNA promoter regions. Previously, we have found that Id3 induced apoptosis in immortalized human keratinocytes upon UVB exposure, consistent with its role as a tumor suppressor. To investigate the role of Id3 in malignant squamous cell carcinoma (SCC) cells (A431), a tetracycline-regulated inducible system was used to induce Id3 in cell culture and mouse xenograft models. We found that upon Id3 induction, there was a decrease in cell number under low serum conditions, as well as in soft agar. Microarray, RT-PCR, immunoblot, siRNA, and inhibitor studies revealed that Id3 induced expression of Elk-1, an E-twenty-six (ETS)-domain transcription factor, inducing procaspase-8 expression and activation. Id3 deletion mutants revealed that 80 C-terminal amino acids, including the HLH, are important for Id3-induced apoptosis. In a mouse xenograft model, Id3 induction decreased tumor size by 30%. Using immunofluorescent analysis, we determined that the tumor size decrease was also mediated through apoptosis. Furthermore, we show that Id3 synergizes with 5-FU and cisplatin therapies for nonmelanoma skin cancer cells. Our studies have shown a molecular mechanism by which Id3 induces apoptosis in SCC, and this information can potentially be used to develop new treatments for SCC patients
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Operations of and Future Plans for the Pierre Auger Observatory
Energy Technology Data Exchange (ETDEWEB)
Abraham, : J.; Abreu, P.; Aglietta, M.; Aguirre, C.; Ahn, E.J.; Allard, D.; Allekotte, I.; Allen, J.; Alvarez-Muniz, J.; Ambrosio, M.; Anchordoqui, L.
2009-06-01
These are presentations to be presented at the 31st International Cosmic Ray Conference, in Lodz, Poland during July 2009. It consists of the following presentations: (1) Performance and operation of the Surface Detectors of the Pierre Auger Observatory; (2) Extension of the Pierre Auger Observatory using high-elevation fluorescence telescopes (HEAT); (3) AMIGA - Auger Muons and Infill for the Ground Array of the Pierre Auger Observatory; (4) Radio detection of Cosmic Rays at the southern Auger Observatory; (5) Hardware Developments for the AMIGA enhancement at the Pierre Auger Observatory; (6) A simulation of the fluorescence detectors of the Pierre Auger Observatory using GEANT 4; (7) Education and Public Outreach at the Pierre Auger Observatory; (8) BATATA: A device to characterize the punch-through observed in underground muon detectors and to operate as a prototype for AMIGA; and (9) Progress with the Northern Part of the Pierre Auger Observatory.
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Solar Imagery - Photosphere - Sunspot Drawings - McMath-Hulbert Observatory
National Oceanic and Atmospheric Administration, Department of Commerce — The McMath-Hulbert Observatory is a decommissioned solar observatory in Lake Angelus, Michigan, USA. It was established in 1929 as a private observatory by father...
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On the discovery of K I 7699 Å line strength variation during the 1982-1984 eclipse of ε Aurigae
Parthasarathy, M.
2017-02-01
The discovery of K I 7699 Å line strength variations during the 1982-1984 eclipse of ε Aurigae is described. The equivalent widths and radial velocities of the K I 7699 Å line derived from spectra obtained during 1981 November-1983 July with the 2.1 m Otto Struve reflector telescope of the McDonald observatory are presented.
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Wehn, Uta; Joshi, Somya; Pfeiffer, Ellen; Anema, Kim; Gharesifard, Mohammad; Momani, Abeer
2017-04-01
Owing to ICT-enabled citizen observatories, citizens can take on new roles in environmental monitoring, decision making and co-operative planning, and environmental stewardship. And yet implementing advanced citizen observatories for data collection, knowledge exchange and interactions to support policy objectives is neither always easy nor successful, given the required commitment, trust, and data reliability concerns. Many efforts are facing problems with the uptake and sustained engagement by citizens, limited scalability, unclear long-term sustainability and limited actual impact on governance processes. Similarly, to sustain the engagement of decision makers in citizen observatories, mechanisms are required from the start of the initiative in order to have them invest in and, hence, commit to and own the entire process. In order to implement sustainable citizen observatories, these social dimensions therefore need to be soundly managed. We provide empirical evidence of how the social dimensions of citizen observatories are being addressed in the Ground Truth 2.0 project, drawing on a range of relevant social science approaches. This project combines the social dimensions of citizen observatories with enabling technologies - via a socio-technical approach - so that their customisation and deployment is tailored to the envisaged societal and economic impacts of the observatories. The projects consists of the demonstration and validation of six scaled up citizen observatories in real operational conditions both in the EU and in Africa, with a specific focus on flora and fauna as well as water availability and water quality for land and natural resources management. The demonstration cases (4 EU and 2 African) cover the full 'spectrum' of citizen-sensed data usage and citizen engagement, and therefore allow testing and validation of the socio-technical concept for citizen observatories under a range of conditions.
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The Paris Observatory has 350 years
Lequeux, James
2017-01-01
The Paris Observatory is the oldest astronomical observatory that has worked without interruption since its foundation to the present day. The building due to Claude Perrault is still in existence with few modifications, but of course other buildings have been added all along the centuries for housing new instruments and laboratories. In particular, a large dome has been built on the terrace in 1847, with a 38-cm diameter telescope completed in 1857: both are still visible. The main initial purpose of the Observatory was to determine longitudes. This was achieved by Jean-Dominique Cassini using the eclipses of the satellites of Jupiter: a much better map of France was the produced using this method, which unfortunately does not work at sea. Incidentally, the observation of these eclipses led to the discovery in 1676 of the finite velocity of light by Cassini and Rømer. Cassini also discovered the differential rotation of Jupiter and four satellites of Saturn. Then, geodesy was to be the main activity of the Observatory for more than a century, culminating in the famous Cassini map of France completed around 1790. During the first half of the 19th century, under François Arago, the Observatory was at the centre of French physics, which then developed very rapidly. Arago initiated astrophysics in 1810 by showing that the Sun and stars are made of incandescent gas. In 1854, the new director, Urbain Le Verrier, put emphasis on astrometry and celestial mechanics, discovering in particular the anomalous advance of the perihelion of Mercury, which was later to be a proof of General Relativity. In 1858, Leon Foucault built the first modern reflecting telescopes with their silvered glass mirror. Le Verrier created on his side modern meteorology, including some primitive forecasts. The following period was not so bright, due to the enormous project of the Carte du Ciel, which took much of the forces of the Observatory for half a century with little scientific return. In
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2013-02-06
... Services Group, Inc., Commercial/Actuarial/ Information Delivery Services (IDS)/Corporate & Financial... workers and former workers of Hartford Financial Services Group, Inc., Commercial/Actuarial/Information Delivery Services (IDS)/Corporate & Financial Reporting group, Hartford, Connecticut (The Hartford-IDS...
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Identity Management ToolKit (IdM TK)
Department of Veterans Affairs — With the IdM TK, authorized users can search and view identity and exception information from the Administrative Data Repository (ADR). Specifically, users can view...
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The First Astronomical Observatory in Cluj-Napoca
Szenkovits, Ferenc
2008-09-01
One of the most important cities of Romania is Cluj-Napoca (Kolozsvár, Klausenburg). This is a traditional center of education, with many universities and high schools. From the second half of the 18th century the University of Cluj has its own Astronomical Observatory, serving for didactical activities and scientific researches. The famous astronomer Maximillian Hell was one of those Jesuits who put the base of this Astronomical Observatory. Our purpose is to offer a short history of the beginnings of this Astronomical Observatory.
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Visits to La Plata Observatory
Feinstein, A.
1985-03-01
La Plata Observatory will welcome visitors to ESO-La Silla that are willing to make a stop at Buenos Aires on their trip to Chile or on their way back. There is a nice guesthouse at the Observatory that can be used, for a couple of days or so, by astronomers interested in visiting the Observatory and delivering talks on their research work to the Argentine colleagues. No payments can, however, be made at present. La Plata is at 60 km from Buenos Aires. In the same area lie the Instituto de Astronomia y Fisica dei Espacio (IAFE), in Buenos Aires proper, and the Instituto Argentino de Radioastronomia (IAR). about 40 km from Buenos Aires on the way to La Plata. Those interested should contacl: Sr Decano Prof. Cesar A. Mondinalli, or Dr Alejandro Feinstein, Observatorio Astron6mico, Paseo dei Bosque, 1900 La Plata, Argentina. Telex: 31216 CESLA AR.
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Norwegian Ocean Observatory Network (NOON)
Ferré, Bénédicte; Mienert, Jürgen; Winther, Svein; Hageberg, Anne; Rune Godoe, Olav; Partners, Noon
2010-05-01
The Norwegian Ocean Observatory Network (NOON) is led by the University of Tromsø and collaborates with the Universities of Oslo and Bergen, UniResearch, Institute of Marine Research, Christian Michelsen Research and SINTEF. It is supported by the Research Council of Norway and oil and gas (O&G) industries like Statoil to develop science, technology and new educational programs. Main topics relate to ocean climate and environment as well as marine resources offshore Norway from the northern North Atlantic to the Arctic Ocean. NOON's vision is to bring Norway to the international forefront in using cable based ocean observatory technology for marine science and management, by establishing an infrastructure that enables real-time and long term monitoring of processes and interactions between hydrosphere, geosphere and biosphere. This activity is in concert with the EU funded European Strategy Forum on Research Infrastructures (ESFRI) roadmap and European Multidisciplinary Seafloor Observation (EMSO) project to attract international leading research developments. NOON envisions developing towards a European Research Infrastructure Consortium (ERIC). Beside, the research community in Norway already possesses a considerable marine infrastructure that can expand towards an international focus for real-time multidisciplinary observations in times of rapid climate change. PIC The presently established cable-based fjord observatory, followed by the establishment of a cable-based ocean observatory network towards the Arctic from an O&G installation, will provide invaluable knowledge and experience necessary to make a successful larger cable-based observatory network at the Norwegian and Arctic margin (figure 1). Access to large quantities of real-time observation from the deep sea, including high definition video, could be used to provide the public and future recruits to science a fascinating insight into an almost unexplored part of the Earth beyond the Arctic Circle
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Security and Privacy Improvements for the Belgian eID Technology
Verhaeghe, Pieter; Lapon, Jorn; de Decker, Bart; Naessens, Vincent; Verslype, Kristof
The Belgian Electronic Identity Card enables Belgian citizens to prove their identity digitally and to sign electronic documents. At the end of 2009, every Belgian citizen older than 12 years will have such an eID card. In the future, usage of the eID card may be mandatory. However, irresponsible use of the card may cause harm to individuals.
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Energy Technology Data Exchange (ETDEWEB)
Jared Verba; Michael Milvich
2008-05-01
Current Intrusion Detection System (IDS) technology is not suited to be widely deployed inside a Supervisory, Control and Data Acquisition (SCADA) environment. Anomaly- and signature-based IDS technologies have developed methods to cover information technology-based networks activity and protocols effectively. However, these IDS technologies do not include the fine protocol granularity required to ensure network security inside an environment with weak protocols lacking authentication and encryption. By implementing a more specific and more intelligent packet inspection mechanism, tailored traffic flow analysis, and unique packet tampering detection, IDS technology developed specifically for SCADA environments can be deployed with confidence in detecting malicious activity.
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Electricity and gas market observatory. 3. Quarter 2007
International Nuclear Information System (INIS)
2007-01-01
The purpose of the observatory is to provide the general public with indicators for monitoring market deregulation. It both covers the wholesale and retail electricity and gas markets in Metropolitan France. This observatory is updated every three months and data are available on CRE web site (www.cre.fr). Since the 1 of July 2007, all customers can choose their gas and electricity suppliers. The present observatory is including residential customer's statistics. Content: A - The electricity market: The retail electricity market (Introduction, Customer segments and their respective weight, Status at September 30, 2007, Dynamic analysis: 3. Quarter 2007); The wholesale electricity market (Introduction, Wholesale market activity in France, Wholesale market activity in France, Prices on the French wholesale market and European comparison, Import and export volumes, Concentration of the French electricity market); B - The gas market: The retail gas market (Introduction, Customer segments and their respective weight, Status on September 30, 2007, Dynamic analysis: 3. Quarter 2007); The wholesale gas market (Gas pricing and gas markets in Europe, The wholesale market in France); C - Appendices: Electricity and gas market observatories combined glossary, Specific electricity market observatory glossary, Specific gas market observatory glossary
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78 FR 25406 - Proposed Modification of Class E Airspace; Twin Falls, ID
2013-05-01
...) Global Positioning System (GPS) and the Instrument Landing System (ILS) or Localizer (LOC) standard... the earth. * * * * * ANM ID E5 Twin Falls, ID [Modified] Twin Falls Joslin Field-Magic Valley Regional...
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Science Potential of a Deep Ocean Antineutrino Observatory
International Nuclear Information System (INIS)
Dye, S.T.
2007-01-01
This paper presents science potential of a deep ocean antineutrino observatory being developed at Hawaii. The observatory design allows for relocation from one site to another. Positioning the observatory some 60 km distant from a nuclear reactor complex enables precision measurement of neutrino mixing parameters, leading to a determination of neutrino mass hierarchy and θ 13 . At a mid-Pacific location the observatory measures the flux and ratio of uranium and thorium decay neutrinos from earth's mantle and performs a sensitive search for a hypothetical natural fission reactor in earth's core. A subsequent deployment at another mid-ocean location would test lateral heterogeneity of uranium and thorium in earth's mantle
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78 FR 45478 - Proposed Establishment of Class E Airspace; Salmon, ID
2013-07-29
...-0531; Airspace Docket No. 13-ANM-20] Proposed Establishment of Class E Airspace; Salmon, ID AGENCY... action proposes to establish Class E airspace at the Salmon VHF Omni-Directional Radio Range/Distance Measuring Equipment (VOR/DME) navigation aid, Salmon, ID, to facilitate vectoring of Instrument Flight Rules...
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Muon Identification performance: hadron mis-Id measurements and RPC Muon selections
CMS Collaboration
2014-01-01
Pion, kaon, proton mis-identification probabilities as muons have been measured for different Muon ID algorithms. Results from two independent analyses are presented. The performance of a new muon ID algorithm based on matching of inner tracks with hits in muon RPC chambers is also presented.
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Science requirements and the design of cabled ocean observatories
Directory of Open Access Journals (Sweden)
H. Mikada
2006-06-01
Full Text Available The ocean sciences are beginning a new phase in which scientists will enter the ocean environment and adaptively observe the Earth-Ocean system through remote control of sensors and sensor platforms. This new ocean science paradigm will be implemented using innovative facilities called ocean observatories which provide unprecedented levels of power and communication to access and manipulate real-time sensor networks deployed within many different environments in the ocean basins. Most of the principal design drivers for ocean observatories differ from those for commercial submarine telecommunications systems. First, ocean observatories require data to be input and output at one or more seafloor nodes rather than at a few land terminuses. Second, ocean observatories must distribute a lot of power to the seafloor at variable and fluctuating rates. Third, the seafloor infrastructure for an ocean observatory inherently requires that the wet plant be expandable and reconfigurable. Finally, because the wet communications and power infrastructure is comparatively complex, ocean observatory infrastructure must be designed for low life cycle cost rather than zero maintenance. The origin of these differences may be understood by taking a systems engineering approach to ocean observatory design through examining the requirements derived from science and then going through the process of iterative refinement to yield conceptual and physical designs. This is illustrated using the NEPTUNE regional cabled observatory power and data communications sub-systems.
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Directory of Open Access Journals (Sweden)
Finn Hedefalk
2014-09-01
Full Text Available The Intermediate Data Structure (IDS is a standardised database structure for longitudinal historical databases. Such a common structure facilitates data sharing and comparative research. In this study, we propose an extended version of IDS, named IDS-Geo, that also includes geographic data. The geographic data that will be stored in IDS-Geo are primarily buildings and/or property units, and the purpose of these geographic data is mainly to link individuals to places in space. When we want to assign such detailed spatial locations to individuals (in times before there were any detailed house addresses available, we often have to create tailored geographic datasets. In those cases, there are benefits of storing geographic data in the same structure as the demographic data. Moreover, we propose the export of data from IDS-Geo using an eXtensible Markup Language (XML Schema. IDS-Geo is implemented in a case study using historical property units, for the period 1804 to 1913, stored in a geographically extended version of the Scanian Economic Demographic Database (SEDD. To fit into the IDS-Geo data structure, we included an object lifeline representation of all of the property units (based on the snapshot time representation of single historical maps and poll-tax registers. The case study verifies that the IDS-Geo model is capable of handling geographic data that can be linked to demographic data.
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The South African Astronomical Observatory
International Nuclear Information System (INIS)
1988-01-01
The geographical position, climate and equipment at the South African Astronomical Observatory (SAAO), together with the enthusiasm and efforts of SAAO scientific and technical staff and of visiting scientists, have enabled the Observatory to make a major contribution to the fields of astrophysics and cosmology. During 1987 the SAAO has been involved in studies of the following: supernovae; galaxies, including Seyfert galaxies; celestial x-ray sources; magellanic clouds; pulsating variables; galatic structure; binary star phenomena; nebulae; interstellar matter and stellar astrophysics
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ACE insertion/deletion (I/D) polymorphism and diabetic nephropathy.
Rahimi, Zohreh
2012-10-01
Angiotensin converting enzyme (ACE) gene encodes ACE, a key component of renin angiotensin system (RAS), plays an important role in blood pressure homeostasis by generating the vasoconstrictor peptide angiotensin II. Directory of Open Access Journals (DOAJ), Google Scholar, Pubmed (NLM), LISTA (EBSCO) and Web of Science have been searched. The presence of ACE insertion/deletion (I/D) polymorphism affects the plasma level of ACE. ACE DD genotype is associated with the highest systemic and renal ACE levels compared with the lowest ACE activity in carriers of II genotype. In this review focus has been performed on the study of ACE I/D polymorphism in various populations and its influence on the risk of onset and progression of diabetic nephropathy. Also, association between ACE I/D polymorphism and response to ACE inhibitor and angiotensin II receptor antagonists will be reviewed. Further, synergistic effect of this polymorphism and variants of some genes on the risk of development of diabetic nephropathy will be discussed.
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van Wijk, Esmee M.; Rintoul, Stephen R.; Ronai, Belinda M.; Williams, Guy D.
2010-05-01
The fine-scale circulation around the Heard and McDonald Islands and through the Fawn Trough, Kerguelen Plateau, is described using data from three high-resolution CTD sections, Argo floats and satellite maps of chlorophyll a, sea surface temperature (SST) and absolute sea surface height (SSH). We confirm that the Polar Front (PF) is split into two branches over the Kerguelen Plateau, with the NPF crossing the north-eastern limits of our survey carrying 25 Sv to the southeast. The SPF was associated with a strong eastward-flowing jet carrying 12 Sv of baroclinic transport through the deepest part of Fawn Trough (relative to the bottom). As the section was terminated midway through the trough this estimate is very likely to be a lower bound for the total transport. We demonstrate that the SPF contributes to the Fawn Trough Current identified by previous studies. After exiting the Fawn Trough, the SPF crossed Chun Spur and continued as a strong north-westward flowing jet along the eastern flank of the Kerguelen Plateau before turning offshore between 50°S and 51.5°S. Measured bottom water temperatures suggest a deep water connection between the northern and southern parts of the eastern Kerguelen Plateau indicating that the deep western boundary current continues at least as far north as 50.5°S. Analysis of satellite altimetry derived SSH streamlines demonstrates a southward shift of both the northern and southern branches of the Polar Front from 1994 to 2004. In the direct vicinity of the Heard and McDonald islands, cool waters of southern origin flow along the Heard Island slope and through the Eastern Trough bringing cold Winter Water (WW) onto the plateau. Complex topography funnels flow through canyons, deepens the mixed layer and increases productivity, resulting in this area being the preferred foraging region for a number of satellite-tracked land-based predators.
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Setting-up a small observatory from concept to construction
Arditti, David
2008-01-01
Every amateur astronomer who is considering a purpose-built observatory will find this book absolutely invaluable during both the planning and the construction stages. Drawing on David Arditti’s practical experience and that of many other amateur astronomers, it gives invaluable help in making all the important decisions. To begin with, Setting up a Small Observatory addresses what you really need from an observatory, whether to build or buy, what designs you should consider, and where you should site it. Uniquely, it also considers the aesthetics of an amateur observatory: how to make it fit in with your home, garden, and yard, even disguising it as a more common garden building if necessary. There’s also a wealth of practical details for constructing and equipping your small observatory – everything from satisfying local planning laws and building codes through to making sure that your completed observatory is well-equipped, convenient, and comfortable to use. Whether you are considering a simple low-...
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Independence Day 2004 (ID04) / Raul Hindov
Hindov, Raul
2004-01-01
Ülevaade 20.-22. veebruarini 2004 toimunud kaugluurepatrullide rännaku ja sõdurioskuste kompleksõppusest ID04 (Independence Day 2004 - Iseseisvuspäev 2004), millel osales 25 patrullvõistlusteks valmistuvat meest ja naist
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Neutron-capture Nucleosynthesis in the First Stars
Roederer, Ian U.; Preston, George W.; Thompson, Ian B.; Shectman, Stephen A.; Sneden, Christopher
2014-04-01
Recent studies suggest that metal-poor stars enhanced in carbon but containing low levels of neutron-capture elements may have been among the first to incorporate the nucleosynthesis products of the first generation of stars. We have observed 16 stars with enhanced carbon or nitrogen using the MIKE Spectrograph on the Magellan Telescopes at Las Campanas Observatory and the Tull Spectrograph on the Smith Telescope at McDonald Observatory. We present radial velocities, stellar parameters, and detailed abundance patterns for these stars. Strontium, yttrium, zirconium, barium, europium, ytterbium, and other heavy elements are detected. In four stars, these heavy elements appear to have originated in some form of r-process nucleosynthesis. In one star, a partial s-process origin is possible. The origin of the heavy elements in the rest of the sample cannot be determined unambiguously. The presence of elements heavier than the iron group offers further evidence that zero-metallicity rapidly rotating massive stars and pair instability supernovae did not contribute substantial amounts of neutron-capture elements to the regions where the stars in our sample formed. If the carbon- or nitrogen-enhanced metal-poor stars with low levels of neutron-capture elements were enriched by products of zero-metallicity supernovae only, then the presence of these heavy elements indicates that at least one form of neutron-capture reaction operated in some of the first stars. This paper includes data gathered with the 6.5 m Magellan Telescopes located at Las Campanas Observatory, Chile, and The McDonald Observatory of The University of Texas at Austin.
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Ten years of the Spanish Virtual Observatory
Solano, E.
2015-05-01
The main objective of the Virtual Observatory (VO) is to guarantee an easy and efficient access and analysis of the information hosted in astronomical archives. The Spanish Virtual Observatory (SVO) is a project that was born in 2004 with the goal of promoting and coordinating the VO-related activities at national level. SVO is also the national contact point for the international VO initiatives, in particular the International Virtual Observatory Alliance (IVOA) and the Euro-VO project. The project, led by Centro de Astrobiología (INTA-CSIC), is structured around four major topics: a) VO compliance of astronomical archives, b) VO-science, c) VO- and data mining-tools, and d) Education and outreach. In this paper I will describe the most important results obtained by the Spanish Virtual Observatory in its first ten years of life as well as the future lines of work.
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Science Potential of a Deep Ocean Antineutrino Observatory
Energy Technology Data Exchange (ETDEWEB)
Dye, S.T. [Department of Physics and Astronomy, University of Hawaii, 2505 Correa Road, Honolulu, Hawaii, 96822 (United States); College of Natural Sciences, Hawaii Pacific University, 45-045 Kamehameha Highway, Kaneohe, Hawaii 96744 (United States)
2007-06-15
This paper presents science potential of a deep ocean antineutrino observatory being developed at Hawaii. The observatory design allows for relocation from one site to another. Positioning the observatory some 60 km distant from a nuclear reactor complex enables precision measurement of neutrino mixing parameters, leading to a determination of neutrino mass hierarchy and {theta}{sub 13}. At a mid-Pacific location the observatory measures the flux and ratio of uranium and thorium decay neutrinos from earth's mantle and performs a sensitive search for a hypothetical natural fission reactor in earth's core. A subsequent deployment at another mid-ocean location would test lateral heterogeneity of uranium and thorium in earth's mantle.
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International Nuclear Information System (INIS)
Noetzel, Erik; Veeck, Jürgen; Niederacher, Dieter; Galm, Oliver; Horn, Felicitas; Hartmann, Arndt; Knüchel, Ruth; Dahl, Edgar
2008-01-01
Inhibitor of DNA binding/Inhibitor of differentiation 4 (ID4) is a critical factor for cell proliferation and differentiation in normal vertebrate development. ID4 has regulative functions for differentiation and growth of the developing brain. The role of ID1, ID2 and ID3 are expected to be oncogenic due to their overexpression in pancreatic cancer and colorectal adenocarcinomas, respectively. Aside from these findings, loss of ID3 expression was demonstrated in ovarian cancer. The aim of the present study was to reveal the factual role of ID4 in carcinogenesis in more detail, since its role for the pathogenesis of human breast cancer has been discussed controversially, assigning both oncogenic and tumour suppressive functions. ID4 promoter methylation, ID4 mRNA expression and ID4 protein expression were analysed in primary human breast cancer specimens using methylation-specific PCR (MSP) (n=170), semiquantitative realtime RT-PCR (n=46) and immunhistochemistry (n=3), respectively. In order to demonstrate a functional association of ID4 promoter methylation with its gene silencing, we performed DNA demethylation analysis with four human breast cell lines using MSP and semiquantitative realtime RT-PCR. In addition, we performed correlations of ID4 promoter methylation with ID4 mRNA and ID4 protein expression in matched samples of breast tumour and corresponding normal tissue. We carried out statistical analyses in order to find correlations between ID4 promoter methylation and clinicopathological parameters. Frequent ID4 promoter methylation was observed in primary breast cancer samples (69%, 117/170). We found a tight correlation (P<0.0001) between ID4 promoter methylation and loss of ID4 expression in primary breast cancer 3 specimens. Demethylating treatment with breast cancer cell lines was associated with clear ID4 mRNA re-expression. Tumours with ID4 promoter methylation showed distinct loss of ID4 expression on both transcription and protein level
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Increased Inhibitor of Differentiation 4 (Id4 Expression in Glioblastoma: A Tissue Microarray Study
Directory of Open Access Journals (Sweden)
Weifin Zeng, Elisabeth J. Rushing, Daniel P. Hartmann, Norio Azumi
2010-01-01
Full Text Available Background: The inhibitor of differentiation/DNA binding protein family (Id1-4 is involved in cell cycle control, tumorigenesis and angiogenesis through the negative regulation of helix-loop-helix transcription factors. Of these proteins, Id4 is known to play an important role in neural stem cell differentiation, and deregulation has been implicated in glial neoplasia. However, the expression and significance of Id4 in astrocytomas has not been fully addressed. Herein we report the differential expression of Id4 in astrocytomas of various grades using tissue microarrays (TMA and immunohistochemistry (IHC. Design: The GBM TMA was constructed from 53 archival cases at Georgetown University Hospital and a TMA with normal brain controls and grades II-III astrocytoma was obtained from Cybrdi (Rockville, MD. TMA sections were stained with Id4 antibody and the slides were scored according to the percentage of staining astrocytic nuclei (<9% -, 10-50% +, >51% ++. The Fisher Exact test was used to test for statistical significance. Results: Nuclear staining for Id4 was seen in 73.58% GBMs, 25% grade III, and 12.5% grade II astrocytomas; staining was absent in normal brain tissue. There was a statistically significant difference between GBM and grades II, III astrocytoma (p <0.01. Significant Id4 expression was not detected in normal brain. Conclusions: Our study confirms the frequent upregulation of Id4 expression in GBM, which lends support to its role in tumorigenesis, possibly in the transformation of low to high-grade astrocytoma (i.e. GBM. Further studies are warranted to determine the precise role of Id4 in glial neoplasia and its potential use in targeted therapy for GBM.
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The McDonaldization of childhood: children's mental health in neo-liberal market cultures.
Timimi, Sami
2010-11-01
As the failings of neo-liberalism have recently been revealed through the collapse of much of the banking and financial services sector, it seems an opportune time to think about the impact this economic, political, and social value system has had on the well-being of children. After analyzing how our beliefs and practices around children and families are shaped by a variety of economic, political, and cultural pressures, I discuss how policies that promote a particular form of aggressive capitalism lead to a narcissistic value system that permeates social institutions, including those that deal with children. Not only does this impact children's emotional well-being, but it also shapes the way we conceptualize children and their problems. These dynamics facilitate the rapid growth of child psychiatric diagnoses and the tendency to deal with aberrant behavior or emotions in children through technical--particularly pharmaceutical--interventions, a phenomenon I refer to as the 'McDonaldization' of children's mental health. The present article seeks to challenge many of the unhelpful cultural assumptions regarding childhood embedded within the narrow biomedical frame that neo-liberalism has encouraged.
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Development of Armenian-Georgian Virtual Observatory
Mickaelian, Areg; Kochiashvili, Nino; Astsatryan, Hrach; Harutyunian, Haik; Magakyan, Tigran; Chargeishvili, Ketevan; Natsvlishvili, Rezo; Kukhianidze, Vasil; Ramishvili, Giorgi; Sargsyan, Lusine; Sinamyan, Parandzem; Kochiashvili, Ia; Mikayelyan, Gor
2009-10-01
The Armenian-Georgian Virtual Observatory (ArGVO) project is the first initiative in the world to create a regional VO infrastructure based on national VO projects and regional Grid. The Byurakan and Abastumani Astrophysical Observatories are scientific partners since 1946, after establishment of the Byurakan observatory . The Armenian VO project (ArVO) is being developed since 2005 and is a part of the International Virtual Observatory Alliance (IVOA). It is based on the Digitized First Byurakan Survey (DFBS, the digitized version of famous Markarian survey) and other Armenian archival data. Similarly, the Georgian VO will be created to serve as a research environment to utilize the digitized Georgian plate archives. Therefore, one of the main goals for creation of the regional VO is the digitization of large amounts of plates preserved at the plate stacks of these two observatories. The total amount of plates is more than 100,000 units. Observational programs of high importance have been selected and some 3000 plates will be digitized during the next two years; the priority is being defined by the usefulness of the material for future science projects, like search for new objects, optical identifications of radio, IR, and X-ray sources, study of variability and proper motions, etc. Having the digitized material in VO standards, a VO database through the regional Grid infrastructure will be active. This partnership is being carried out in the framework of the ISTC project A-1606 "Development of Armenian-Georgian Grid Infrastructure and Applications in the Fields of High Energy Physics, Astrophysics and Quantum Physics".
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International Nuclear Information System (INIS)
Endl, Michael; Castanheira, Barbara G.; Cochran, William D.; Bean, Jacob L.; Wittenmyer, Robert A.; Hatzes, Artie P.
2009-01-01
We present a first analysis of our asteroseismology campaign on the planet host star γ Cep A. We used seven consecutive nights at the Harlan J. Smith 2.7 m telescope at McDonald Observatory to obtain 1200 highly precise radial velocity measurements. We find the star to be a multi-periodic pulsator with a frequency spacing of 15 μHz.
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Astronomical Research with the MicroObservatory Net
Brecher, K.; Sadler, P.; Gould, R.; Leiker, S.; Antonucci, P.; Deutsch, F.
1997-05-01
We have developed a fully integrated automated astronomical telescope system which combines the imaging power of a cooled CCD, with a self-contained and weatherized 15 cm reflecting optical telescope and mount. The MicroObservatory Net consists of five of these telescopes. They are currently being deployed around the world at widely distributed longitudes. Remote access to the MicroObservatories over the Internet has now been implemented. Software for computer control, pointing, focusing, filter selection as well as pattern recognition have all been developed as part of the project. The telescopes can be controlled in real time or in delay mode, from a Macintosh, PC or other computer using Web-based software. The Internet address of the telescopes is http://cfa- www.harvard.edu/cfa/sed/MicroObservatory/MicroObservatory.html. In the real-time mode, individuals have access to all of the telescope control functions without the need for an `on-site' operator. Users can sign up for a specific period of ti me. In the batch mode, users can submit requests for delayed telescope observations. After a MicroObservatory completes a job, the user is automatically notified by e-mail that the image is available for viewing and downloading from the Web site. The telescopes were designed for classroom instruction, as well as for use by students and amateur astronomers for original scientific research projects. We are currently examining a variety of technical and educational questions about the use of the telescopes including: (1) What are the best approaches to scheduling real-time versus batch mode observations? (2) What criteria should be used for allocating telescope time? (3) With deployment of more than one telescope, is it advantageous for each telescope to be used for just one type of observation, i.e., some for photometric use, others for imaging? And (4) What are the most valuable applications of the MicroObservatories in astronomical research? Support for the MicroObservatory
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International Nuclear Information System (INIS)
Ewan, G.T.; Evans, H.C.; Lee, H.W.
1986-10-01
This report is a supplement to a report (SNO-85-3 (Sudbury Neutrino Observatory)) which contained the results of a feasibility study on the construction of a deep underground neutrino observatory based on a 1000 ton heavy water Cerenkov detector. Neutrinos carry detailed information in their spectra on the reactions taking place deep in the interstellar interior and also provide information on supernova explosions. In addition to their role as astrophysical probes, a knowledge of the properties of neutrinos is crucial to theories of grand unification. The Sudbury Neutrino Observatory is unique in its high sensitivity to electron neutrinos and its ability to detect all other types of neutrinos of energy greater than 2.2 MeV. The results of the July 1985 study indicated that the project is technically feasible in that the proposed detector can measure the direction and energy of electron neutrinos above 7 MeV and the scientific programs will make significant contributions to physics and astrophysics. This present report contains new information obtained since the 1985 feasibility study. The enhanced conversion of neutrinos in the sun and the new physics that could be learned using the heavy water detector are discussed in the physics section. The other sections will discuss progress in the areas of practical importance in achieving the physics objectives such as new techniques to measure, monitor and remove low levels of radioactivity in detector components, ideas on calibration of the detector and so forth. The section entitled Administration contains a membership list of the working groups within the SNO collaboration
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Directory of Open Access Journals (Sweden)
Cǎtǎlin NAE
2010-03-01
Full Text Available This paper is dedicated to a very specific type of analysis tool (VLM - Vortex Lattice Method to be integrated in a IDS - Integrated Design System, tailored for the usage of small aircraft industry. The major interest is to have the possibility to simulate at very low computational costs a preliminary set of aerodynamic characteristics for basic aerodynamic global characteristics (Lift, Drag, Pitching Moment and aerodynamic derivatives for longitudinal and lateral-directional stability analysis. This work enables fast investigations of the influence of configuration changes in a very efficient computational environment. Using experimental data and/or CFD information for a specific calibration of VLM method, reliability of the analysis may me increased so that a first type (iteration zero aerodynamic evaluation of the preliminary 3D configuration is possible. The output of this tool is basic state aerodynamic and associated stability and control derivatives, as well as a complete set of information on specific loads on major airframe components.The major interest in using and validating this type of methods is coming from the possibility to integrate it as a tool in an IDS system for conceptual design phase, as considered for development for CESAR project (IP, UE FP6.
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Long Baseline Observatory (LBO)
Federal Laboratory Consortium — The Long Baseline Observatory (LBO) comprises ten radio telescopes spanning 5,351 miles. It's the world's largest, sharpest, dedicated telescope array. With an eye...
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Implementasi Cell ID dan GPS dalam Pencarian Lokasi Fasilitas Kesehatan Terdekat
Directory of Open Access Journals (Sweden)
Fahmi Candra Permana
2017-07-01
Full Text Available Cell ID dan GPS merupakan layanan berbasis lokasi dan teknologi yang banyak membantu manusia dalam hal navigasi dan penemuan tempat-tempat yang bermanfaat di sekitarnya. Salah satu komponen utama dari teknologi ini dapat diterapkan pada telepon seluler. Dalam penelitian ini, dirancang sebuah aplikasi dengan memanfaatkan teknologi berdasar implementasi dari Cell ID dan GPS untuk mengetahui posisi user dan lokasi fasilitas kesehatan terdekat di sekitar user dan penggunaan JSON sebagai sarana untuk menyimpan database pada web. Aplikasi ini diimplementasikan pada telepon seluler dengan sistem operasi Android. Hasil dari penelitian ini menunjukkan bahwa Cell ID dan GPS dapat diimplementasikan dengan baik dengan memanfaatkan akses Internet dan Google Maps untuk mencari fasilitas kesehatan terdekat dan menggambarkan daerah sekitar user.
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Electricity and gas market observatory. 2. Quarter 2008
International Nuclear Information System (INIS)
2008-01-01
The purpose of the observatory is to provide the general public with indicators for monitoring market deregulation. It both covers the wholesale and retail electricity and gas markets in Metropolitan France. This observatory is updated every three months and data are available on CRE web site (www.cre.fr). Since the 1 of July 2007, all customers can choose their gas and electricity suppliers. Content: A - The electricity market: The retail electricity market (Introduction, Customer segments and their respective weight, Status at June 30, 2008, Dynamic analysis: 2. Quarter 2008); The wholesale electricity market (Introduction, Wholesale market activity in France, Prices on the French wholesale market and European comparison, Import and export volumes, Concentration of the French electricity market); B - The gas market: The retail gas market (Introduction, Customer segments and their respective weight, Status on June 30, 2008, Dynamic analysis: 2. Quarter 2008); The wholesale gas market (Gas pricing and gas markets in Europe, The wholesale market in France); C - Appendices: Electricity and gas market observatories combined glossary, Specific electricity market observatory glossary, Specific gas market observatory glossary
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International Nuclear Information System (INIS)
Maw, Min Khine; Fujimoto, Jiro; Tamaya, Teruhiko
2009-01-01
The inhibitor of DNA-binding (ID) has been involved in cell cycle regulation, apoptosis and angiogenesis. This prompted us to study ID functions in tumor advancement of ovarian cancers. Sixty patients underwent surgery for ovarian cancers. In ovarian cancers, the levels of ID-1, ID-2 and ID-3 mRNAs were determined by real-time reverse transcription-polymerase chain reaction. The histoscore with the localization of ID-1 was determined by immunohistochemistry. Patient prognosis was analyzed with a 36-month survival rate. Microvessel counts were determined by immunohistochemistry for CD34 and factor VIII-related antigen. ID-1 histoscores and mRNA levels both significantly (p < 0.001) increased in ovarian cancers according to clinical stage, regardless of histopathological type. Furthermore, 30 patients with high ID-1 expression had a lower survival rate (53%) compared to patients with low ID-1 expression (80%). ID-1 histoscores and mRNA levels significantly (p < 0.0001) correlated with microvessel counts in ovarian cancers. ID-1 increased in ovarian cancer cells during tumor progression. Moreover, ID-1 expression levels correlated with microvessel counts. Therefore, ID-1 might work on tumor advancement via angiogenesis and is considered to be a candidate for a prognostic indicator in ovarian cancers
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Social Media Programs at the National Optical Astronomy Observatory
Sparks, Robert T.; Walker, Constance Elaine; Pompea, Stephen M.
2015-08-01
Observatories and other science research organizations want to share their research and activities with the public. The last several years, social media has become and increasingly important venue for communicating information about observatory activities, research and education and public outreach.The National Optical Astronomy Observatory (NOAO) uses a wide variety of social media to communicate with different audiences. NOAO is active on social media platforms including Facebook, Twitter, Google+ and Pinterest. Our social media accounts include those for the National Optical Astronomy Observatory, Cerro Tololo Inter-American Observatory, Kitt Peak National Observatory and our dark skies conservation program Globe at Night.Our social media programs have a variety of audiences. NOAO uses social media to announce and promote NOAO sponsored meetings, observatory news and proposal deadlines to the professional astronomical community. Social media accounts are used to disseminate NOAO press releases, images from the observatory and other science using data from NOAO telescopes.Social media is important in our Education and Public Outreach programs (EPO). Globe at Night has very active facebook and twitter accounts encouraging people to become involved in preserving dark skies. Social media plays a role in recruiting teachers for professional development workshops such as Project Astro.NOAO produces monthly podcasts for the 365 Days of Astronomy podcast featuring interviews with NOAO astronomers. Each podcast highlights the science of an NOAO astronomer, an NOAO operated telescope or instrument, or an NOAO program. A separate series of podcasts is produced for NOAO’s Dark Skies Education programs. All the podcasts are archived at 365daysofastronomy.org.
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Efficient coding and detection of ultra-long IDs for visible light positioning systems.
Zhang, Hualong; Yang, Chuanchuan
2018-05-14
Visible light positioning (VLP) is a promising technique to complement Global Navigation Satellite System (GNSS) such as Global positioning system (GPS) and BeiDou Navigation Satellite System (BDS) which features the advantage of low-cost and high accuracy. The situation becomes even more crucial for indoor environments, where satellite signals are weak or even unavailable. For large-scale application of VLP, there would be a considerable number of Light emitting diode (LED) IDs, which bring forward the demand of long LED ID detection. In particular, to provision indoor localization globally, a convenient way is to program a unique ID into each LED during manufacture. This poses a big challenge for image sensors, such as the CMOS camera in everybody's hands since the long ID covers the span of multiple frames. In this paper, we investigate the detection of ultra-long ID using rolling shutter cameras. By analyzing the pattern of data loss in each frame, we proposed a novel coding technique to improve the efficiency of LED ID detection. We studied the performance of Reed-Solomon (RS) code in this system and designed a new coding method which considered the trade-off between performance and decoding complexity. Coding technique decreases the number of frames needed in data processing, significantly reduces the detection time, and improves the accuracy of detection. Numerical and experimental results show that the detected LED ID can be much longer with the coding technique. Besides, our proposed coding method is proved to achieve a performance close to that of RS code while the decoding complexity is much lower.
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Sierra Stars Observatory Network: An Accessible Global Network
Williams, Richard; Beshore, Edward
2011-03-01
The Sierra Stars Observatory Network (SSON) is a unique partnership among professional observatories that provides its users with affordable high-quality calibrated image data. SSON comprises observatories in the Northern and Southern Hemisphere and is in the process of expanding to a truly global network capable of covering the entire sky 24 hours a day in the near future. The goal of SSON is to serve the needs of science-based projects and programs. Colleges, universities, institutions, and individuals use SSON for their education and research projects. The mission of SSON is to promote and expand the use of its facilities among the thousands of colleges and schools worldwide that do not have access to professional-quality automated observatory systems to use for astronomy education and research. With appropriate leadership and guidance educators can use SSON to help teach astronomy and do meaningful scientific projects. The relatively small cost of using SSON for this type of work makes it affordable and accessible for educators to start using immediately. Remote observatory services like SSON need to evolve to better support education and research initiatives of colleges, institutions and individual investigators. To meet these needs, SSON is developing a sophisticated interactive scheduling system to integrate among the nodes of the observatory network. This will enable more dynamic observations, including immediate priority interrupts, acquiring moving objects using ephemeris data, and more.
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Vibrational measurements in 3-ID-B
International Nuclear Information System (INIS)
Sutter, J.; Alp, E.; Barraza, J.; Shu, D.
1998-04-01
The authors have undertaken a series of vibrational measurements in hutch 3-ID-B. Their motivation was to compare two different methods of mounting an interferometer for effectiveness in vibrational isolation and stability. In addition they were able to compare the stability of the optical table with and without its eight large bolts inserted
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International Nuclear Information System (INIS)
Kurooka, Hisanori; Sugai, Manabu; Mori, Kentaro; Yokota, Yoshifumi
2013-01-01
Highlights: •Sodium arsenite induces cytoplasmic accumulation of Id3. •Arsenite binds to closely spaced N-terminal cysteine residues of Id3. •N-terminal cysteines are essential for arsenite-induced nuclear export of Id3. •Nuclear export of Id3 counteracts its transcriptional repression activity. -- Abstract: Ids are versatile transcriptional repressors that regulate cell proliferation and differentiation, and appropriate subcellular localization of the Id proteins is important for their functions. We previously identified distinct functional nuclear export signals (NESs) in Id1 and Id2, but no active NES has been reported in Id3. In this study, we found that treatment with the stress-inducing metalloid arsenite led to the accumulation of GFP-tagged Id3 in the cytoplasm. Cytoplasmic accumulation was impaired by a mutation in the Id3 NES-like sequence resembling the Id1 NES, located at the end of the HLH domain. It was also blocked by co-treatment with the CRM1-specific nuclear export inhibitor leptomycin B (LMB), but not with the inhibitors for mitogen-activated protein kinases (MAPKs). Importantly, we showed that the closely spaced N-terminal cysteine residues of Id3 interacted with the arsenic derivative phenylarsine oxide (PAO) and were essential for the arsenite-induced cytoplasmic accumulation, suggesting that arsenite induces the CRM1-dependent nuclear export of Id3 via binding to the N-terminal cysteines. Finally, we demonstrated that Id3 significantly repressed arsenite-stimulated transcription of the immediate-early gene Egr-1 and that this repression activity was inversely correlated with the arsenite-induced nuclear export. Our results imply that Id3 may be involved in the biological action of arsenite
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Toward operation of series IDs at BL43LXU of SPring-8
Energy Technology Data Exchange (ETDEWEB)
Baron, A. Q. R.; Tanaka, T.; Soutome, K.; Takao, M.; Nakamura, T.; Kobayashi, K.; Fujita, T.; Takahashi, S.; Aoyagi, H.; Shimosaki, Y.; Seike, T.; Uchiyama, H.; Ishikawa, D.; Chuang, T.-H.; Kimura, H.; Tanaka, H.; Kitamura, H.; Ishikawa, T. [SPring-8, 1-1-1 Kouto, Sayo, Hyogo, 679 (Japan)
2016-07-27
This paper discusses two issues relating to using 3 small gap insertion devices in series at BL43LXU of SPring-8 to make a uniquely powerful source in the 15-26 keV region of the x-ray spectrum. The issues discussed are (1) damage to the covers of the downstream IDs by radiation from the upstream IDs and (2) proper steering of the electron beam to get the best photon beam properties. After tests in several configurations, including one where an ID was run without an impedance-reducing cover, the damage issue was solved by installing a distributed absorber in the most downstream ID. The steering issues were mostly resolved by the introduction of appropriate corrector magnets and feedback. The paper is written from the viewpoint of an interested beamline scientist impressed with the cooperation of different groups to make a source for new science possible.
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ID'ing innate and innate-like lymphoid cells.
Verykokakis, Mihalis; Zook, Erin C; Kee, Barbara L
2014-09-01
The immune system can be divided into innate and adaptive components that differ in their rate and mode of cellular activation, with innate immune cells being the first responders to invading pathogens. Recent advances in the identification and characterization of innate lymphoid cells have revealed reiterative developmental programs that result in cells with effector fates that parallel those of adaptive lymphoid cells and are tailored to effectively eliminate a broad spectrum of pathogenic challenges. However, activation of these cells can also be associated with pathologies such as autoimmune disease. One major distinction between innate and adaptive immune system cells is the constitutive expression of ID proteins in the former and inducible expression in the latter. ID proteins function as antagonists of the E protein transcription factors that play critical roles in lymphoid specification as well as B- and T-lymphocyte development. In this review, we examine the transcriptional mechanisms controlling the development of innate lymphocytes, including natural killer cells and the recently identified innate lymphoid cells (ILC1, ILC2, and ILC3), and innate-like lymphocytes, including natural killer T cells, with an emphasis on the known requirements for the ID proteins. © 2014 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
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Astronomical Virtual Observatories Through International Collaboration
Directory of Open Access Journals (Sweden)
Masatoshi Ohishi
2010-03-01
Full Text Available Astronomical Virtual Observatories (VOs are emerging research environment for astronomy, and 16 countries and a region have funded to develop their VOs based on international standard protocols for interoperability. The 16 funded VO projects have established the International Virtual Observatory Alliance (http://www.ivoa.net/ to develop the standard interoperable interfaces such as registry (meta data, data access, query languages, output format (VOTable, data model, application interface, and so on. The IVOA members have constructed each VO environment through the IVOA interfaces. National Astronomical Observatory of Japan (NAOJ started its VO project (Japanese Virtual Observatory - JVO in 2002, and developed its VO system. We have succeeded to interoperate the latest JVO system with other VOs in the USA and Europe since December 2004. Observed data by the Subaru telescope, satellite data taken by the JAXA/ISAS, etc. are connected to the JVO system. Successful interoperation of the JVO system with other VOs means that astronomers in the world will be able to utilize top-level data obtained by these telescopes from anywhere in the world at anytime. System design of the JVO system, experiences during our development including problems of current standard protocols defined in the IVOA, and proposals to resolve these problems in the near future are described.
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FDIC Institution Directory (ID) -- Insured Insitution Download File
Federal Deposit Insurance Corporation — The FDIC's Institution Directory (ID) download file provides a list of all FDIC-insured institutions. The file includes demographic information related to the...
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The Pierre Auger Cosmic Ray Observatory
Czech Academy of Sciences Publication Activity Database
Aab, A.; Abreu, P.; Aglietta, M.; Boháčová, Martina; Chudoba, Jiří; Ebr, Jan; Grygar, Jiří; Mandát, Dušan; Nečesal, Petr; Palatka, Miroslav; Pech, Miroslav; Prouza, Michael; Řídký, Jan; Schovánek, Petr; Trávníček, Petr; Vícha, Jakub
2015-01-01
Roč. 798, Oct (2015), s. 172-213 ISSN 0168-9002 R&D Projects: GA MŠk(CZ) LG13007; GA MŠk(CZ) 7AMB14AR005; GA ČR(CZ) GA14-17501S Institutional support: RVO:68378271 Keywords : Pierre Auger Observatory * high energy cosmic rays * hybrid observatory * water Cherenkov detectors * air fluorescence detectors Subject RIV: BF - Elementary Particles and High Energy Physics Impact factor: 1.200, year: 2015
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77 FR 68065 - Amendment of Class D and Class E Airspace; Lewiston, ID
2012-11-15
... Measuring Equipment (VOR/ DME), and the Lewiston-Nez Perce Instrument Landing System (ILS) Localizer... feet or more above the surface of the earth. * * * * * ANM ID E5 Lewiston, ID [Modified] Lewiston-Nez...
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The Importance of Marine Observatories and of RAIA in Particular
Directory of Open Access Journals (Sweden)
Luísa Bastos
2016-08-01
Full Text Available Coastal and Oceanic Observatories are important tools to provide information on ocean state, phenomena and processes. They meet the need for a better understanding of coastal and ocean dynamics, revealing regional characteristics and vulnerabilities. These observatories are extremely useful to guide human actions in response to natural events and potential climate change impacts, anticipating the occurrence of extreme weather and oceanic events and helping to minimize consequent personal and material damages and costs.International organizations and local governments have shown an increasing interest in operational oceanography and coastal, marine and oceanic observations, which resulted in substantial investments in these areas. A variety of physical, chemical and biological data have been collected to better understand the specific characteristics of each ocean area and its importance in the global context. Also the general public’s interest in marine issues and observatories has been raised, mainly in relation to vulnerability, sustainability and climate change issues. Data and products obtained by an observatory are hence useful to a broad range of stakeholders, from national and local authorities to the population in general.An introduction to Ocean Observatories, including their national and regional importance, and a brief analysis of the societal interest in these observatories and related issues are presented. The potential of a Coastal and Ocean Observatory is then demonstrated using the RAIA observatory as example. This modern and comprehensive observatory is dedicated to improve operational oceanography, technology and marine science for the North Western Iberian coast, and to provide services to a large range of stakeholders.
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78 FR 40382 - Modification of Class D and E Airspace; Twin Falls, ID
2013-07-05
... using the Navigation (RNAV) Global Positioning System (GPS) and the Instrument Landing System (ILS) or... or more above the surface of the earth. * * * * * ANM ID E5 Twin Falls, ID [Modified] Twin Falls...
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Id2 reinforces TH1 differentiation and inhibits E2A to repress TFH differentiation.
Shaw, Laura A; Bélanger, Simon; Omilusik, Kyla D; Cho, Sunglim; Scott-Browne, James P; Nance, J Philip; Goulding, John; Lasorella, Anna; Lu, Li-Fan; Crotty, Shane; Goldrath, Ananda W
2016-07-01
The differentiation of helper T cells into effector subsets is critical to host protection. Transcription factors of the E-protein and Id families are important arbiters of T cell development, but their role in the differentiation of the TH1 and TFH subsets of helper T cells is not well understood. Here, TH1 cells showed more robust Id2 expression than that of TFH cells, and depletion of Id2 via RNA-mediated interference increased the frequency of TFH cells. Furthermore, TH1 differentiation was blocked by Id2 deficiency, which led to E-protein-dependent accumulation of effector cells with mixed characteristics during viral infection and severely impaired the generation of TH1 cells following infection with Toxoplasma gondii. The TFH cell-defining transcriptional repressor Bcl6 bound the Id2 locus, which provides a mechanism for the bimodal Id2 expression and reciprocal development of TH1 cells and TFH cells.
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Education and public engagement in observatory operations
Gabor, Pavel; Mayo, Louis; Zaritsky, Dennis
2016-07-01
Education and public engagement (EPE) is an essential part of astronomy's mission. New technologies, remote observing and robotic facilities are opening new possibilities for EPE. A number of projects (e.g., Telescopes In Education, MicroObservatory, Goldstone Apple Valley Radio Telescope and UNC's Skynet) have developed new infrastructure, a number of observatories (e.g., University of Arizona's "full-engagement initiative" towards its astronomy majors, Vatican Observatory's collaboration with high-schools) have dedicated their resources to practical instruction and EPE. Some of the facilities are purpose built, others are legacy telescopes upgraded for remote or automated observing. Networking among institutions is most beneficial for EPE, and its implementation ranges from informal agreements between colleagues to advanced software packages with web interfaces. The deliverables range from reduced data to time and hands-on instruction while operating a telescope. EPE represents a set of tasks and challenges which is distinct from research applications of the new astronomical facilities and operation modes. In this paper we examine the experience with several EPE projects, and some lessons and challenges for observatory operation.
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International Nuclear Information System (INIS)
Ewan, G.T.; Mak, H.B.; Robertson, B.C.
1985-07-01
This report discusses the proposal to construct a unique neutrino observatory. The observatory would contain a Cerenkov detector which would be located 2070 m below the earth's surface in an INCO mine at Creighton near Sudbury and would contain 1000 tons of D20 which is an excellent target material. Neutrinos carry detailed information in their spectra on the reactions taking place deep in the interstellar interior and also provide information on supernova explosions. In addition to their role as astrophysical probes a knowledge of the properties of neutrinos is crucial to theories of grand unification. There are three main objectives of the laboratory. The prime objective will be to study B electron neutrinos from the sun by a direct counting method that will measure their energy and direction. The second major objective will be to establish if electron neutrinos change into other neutrino species in transit from the sun to the earth. Finally it is hoped to be able to observe a supernova with the proposed detector. The features of the Sudbury Neutrino Observatory which make it unique are its high sensitivity to electron neutrinos and its ability to detect all other types of neutrinos of energy greater than 2.2 MeV. In section II of this proposal the major physics objectives are discussed in greater detail. A conceptual design for the detector, and measurements and calculations which establish the feasibility of the neutrino experiments are presented in section III. Section IV is comprised of a discussion on the possible location of the laboratory and Section V contains a brief indication of the main areas to be studied in Phase II of the design study
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Overestimation of the 25(OH)D serum concentration with the automated IDS EIA kit.
Cavalier, Etienne; Huberty, Véronique; Cormier, Catherine; Souberbielle, Jean-Claude
2011-02-01
We have recently observed an increasing number of patients presenting very high serum levels of 25-hydroxyvitamin D [25(OH)D] (> 150 ng/mL), which, in all cases, had been measured with the IDS EIA kit adapted on different "open" automated platforms. We performed a comparison between the IDS EIA kit adapted on two different "open"automated platforms and the DiaSorin RIA. We found a systematic bias (higher levels with the IDS EIA kit) for concentrations more than 50-60 ng/mL that was less obvious when the IDS EIA was used in its manual procedure. We thus suggest to use the IDS EIA kit in its manual procedure rather than to adapt it on an automated platform, and to interpret cautiously a 25(OH)D greater than 100 ng/mL with this kit. Copyright © 2011 American Society for Bone and Mineral Research.
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Electricity and gas market observatory. 4. Quarter 2008
International Nuclear Information System (INIS)
2008-01-01
The purpose of the observatory is to provide the general public with indicators for monitoring market deregulation. It both covers the wholesale and retail electricity and gas markets in Metropolitan France. This observatory is updated every three months and data are available on CRE web site (www.cre.fr). Since the 1 of July 2007, all customers can choose their gas and electricity suppliers. Content: A - The electricity market: The retail electricity market (Introduction, Customer segments and their respective weight, Status on December 31, 2008, Dynamic analysis: 4. Quarter 2008); The wholesale electricity market (Introduction, Wholesale market activity in France, Prices on the French wholesale market and European comparison, Import and export volumes, Concentration of the French electricity market); B - The gas market: The retail gas market (Introduction, Customer segments and their respective weight, Status on December 31, 2008, Dynamic analysis: 4. Quarter 2008); The wholesale gas market (Gas pricing and gas markets in Europe, The wholesale market in France, Prices on the French wholesale market and European comparison, Concentration of the French gas market); C - Appendices: Electricity and gas market observatories combined glossary, Specific electricity market observatory glossary, Specific gas market observatory glossary
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Electricity and gas market observatory. 1. Quarter 2008
International Nuclear Information System (INIS)
2008-01-01
The purpose of the observatory is to provide the general public with indicators for monitoring market deregulation. It both covers the wholesale and retail electricity and gas markets in Metropolitan France. This observatory is updated every three months and data are available on CRE web site (www.cre.fr). Since the 1. of July 2007, all customers can choose their gas and electricity suppliers. Content: A - The electricity market: The retail electricity market (Introduction, Customer segments and their respective weight, Status at March 31, 2007, Dynamic analysis: 1. Quarter 2008); The wholesale electricity market (Introduction, Wholesale market activity in France, Prices on the French wholesale market and European comparison, Import and export volumes, Concentration of the French electricity market); B - The gas market: The retail gas market (Introduction, Customer segments and their respective weight, Status on March 31, 2008, Dynamic analysis: 1. Quarter 2008); The wholesale gas market (Gas pricing and gas markets in Europe, The wholesale market in France, Striking fact of the first quarter 2008); C - Appendices: Electricity and gas market observatories combined glossary, Specific electricity market observatory glossary, Specific gas market observatory glossary
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Electricity and gas market observatory. 4. Quarter 2007
International Nuclear Information System (INIS)
2007-01-01
The purpose of the observatory is to provide the general public with indicators for monitoring market deregulation. It both covers the wholesale and retail electricity and gas markets in Metropolitan France. This observatory is updated every three months and data are available on CRE web site (www.cre.fr). Since the 1. of July 2007, all customers can choose their gas and electricity suppliers. Content: A - The electricity market: The retail electricity market (Introduction, Customer segments and their respective weight, Status at December 31, 2007, Dynamic analysis: 4. Quarter 2007); The wholesale electricity market (Introduction, Wholesale market activity in France, Prices on the French wholesale market and European comparison, Import and export volumes, Concentration of the French electricity market, Striking fact of the fourth quarter 2007); B - The gas market: The retail gas market (Introduction, Customer segments and their respective weight, Status on December 31. 2007, Dynamic analysis: 4. Quarter 2007); The wholesale gas market (Gas pricing and gas markets in Europe, The wholesale market in France, Striking fact of the fourth quarter 2007); C - Appendices: Electricity and gas market observatories combined glossary, Specific electricity market observatory glossary, Specific gas market observatory glossary
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Determination of local chromatin composition by CasID.
Schmidtmann, Elisabeth; Anton, Tobias; Rombaut, Pascaline; Herzog, Franz; Leonhardt, Heinrich
2016-09-02
Chromatin structure and function are determined by a plethora of proteins whose genome-wide distribution is typically assessed by immunoprecipitation (ChIP). Here, we developed a novel tool to investigate the local chromatin environment at specific DNA sequences. We combined the programmable DNA binding of dCas9 with the promiscuous biotin ligase BirA* (CasID) to biotinylate proteins in the direct vicinity of specific loci. Subsequent streptavidin-mediated precipitation and mass spectrometry identified both known and previously unknown chromatin factors associated with repetitive telomeric, major satellite and minor satellite DNA. With super-resolution microscopy, we confirmed the localization of the putative transcription factor ZNF512 at chromocenters. The versatility of CasID facilitates the systematic elucidation of functional protein complexes and locus-specific chromatin composition.
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Availability and Access to Data from Kakioka Magnetic Observatory, Japan
Directory of Open Access Journals (Sweden)
Yasuhiro Minamoto
2013-06-01
Full Text Available The Japan Meteorological Agency (JMA is operating four geomagnetic observatories in Japan. Kakioka Magnetic Observatory (KMO, commissioned in 1913, is the oldest. The hourly records at KMO cover over almost 100 years. KMO is JMA's headquarters for geomagnetic and geoelectric observations. Almost all data are available at the KMO website free of charge for researchers. KMO and two other observatories have been certified as INTERMAGNET observatories, and quasi-real-time geomagnetic data from them are available at the INTERMAGNET website.
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The Science and Design of the AGIS Observatory
Schroedter, Martin
2010-02-01
The AGIS observatory is a next-generation array of imaging atmospheric Cherenkov telescopes (IACTs) for gamma-ray astronomy between 100 GeV and 100 TeV. The AGIS observatory is the next logical step in high energy gamma-ray astronomy, offering improved angular resolution and sensitivity compared to FERMI, and overlapping the high energy end of FERMI's sensitivity band. The baseline AGIS observatory will employ an array of 36 Schwarzschild-Couder IACTs in combination with a highly pixelated (0.05^o diameter) camera. The instrument is designed to provide millicrab sensitivity over a wide (8^o diameter) field of view, allowing both deep studies of faint point sources as well as efficient mapping of the Galactic plane and extended sources. I will describe science drivers behind the AGIS observatory and the design and status of the project. )
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The Implementation of C-ID, R2D2 Model on Learning Reading Comprehension
Rayanto, Yudi Hari; Rusmawan, Putu Ngurah
2016-01-01
The purposes of this research are to find out, (1) whether C-ID, R2D2 model is effective to be implemented on learning Reading comprehension, (2) college students' activity during the implementation of C-ID, R2D2 model on learning Reading comprehension, and 3) college students' learning achievement during the implementation of C-ID, R2D2 model on…
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Astronomical Observatory of Belgrade from 1924 to 1955
Radovanac, M.
2014-12-01
History of the Astronomical Observatory in Belgrade, as the presentation is done here, become the field of interest to the author of the present monograph in early 2002. Then, together with Luka C. Popovic, during the Conference "Development of Astronomy among Serbs II" held in early April of that year, he prepared a paper entitled "Astronomska opservatorija tokom Drugog Svetskog rata" (Astronomical Observatory in the Second World War). This paper was based on the archives material concerning the Astronomical Observatory which has been professionally bearing in mind the author's position the subject of his work.
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University Observatory, Ludwig-Maximilians-Universität
Murdin, P.
2000-11-01
The University Observatory of Ludwig-Maximilians-Universität was founded in 1816. Astronomers who worked or graduated at the Munich Observatory include: Fraunhofer, Soldner, Lamont, Seeliger and Karl Schwarzschild. At present four professors and ten staff astronomers work here. Funding comes from the Bavarian Government, the German Science Foundation, and other German and European research progra...
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Anmeldung in ILIAS ohne Uni-Login-ID
Schanz, Nadja
2016-01-01
Gewusst wie...! Online-Tutorial der Universitätsbibliothek Tübingen. Erklärt die Anmeldung in Ilias zu Führungen ohne Uni-Login-ID Online Tutorial from university library tuebingen. teaches how to register in Ilias for courses and guided tours without university login
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On the validity of Ksub(Id)-measurements in instrumented impact tests
International Nuclear Information System (INIS)
Kalthoff, J.F.; Winkler, S.; Klemm, W.; Beinert, J.
1979-01-01
The influence of inertia effects in determining the dynamic fracture toughness Ksub(Id) by instrumented impact testing is investigated. Model experiments in the brittle fracture regime are carried out with precracked bend specimens machined from the epoxy resin Araldite B. As is usual in these tests, the loads at the tup of the impinging striker are recorded as a function of time during the impact process. For reference purposes, the dynamic fracture toughness value Ksub(Id)sup(m1) is derived from the measured maximum load utilizing static stress intensity factor formulas. In addition to this conventional procedure, the actual stress intensity factors are measured directly at the tip of the crack by means of the shadow optical method of caustics applied in combination with high speed photography. The critical value of these optically measured stress intensity factors (for onset of crack propagation), Ksub(Id)sup(opt), is the true dynamic fracture toughness. In the experiments, the specimen size and the impact velocity were varied. In accordance with expectations, it is found that the hammer load signal is not correlated with the actual crack tip stress intensity factor values by a simple proportionality. The conventionally determined Ksub(Id)sup(m1)-value overestimates the true dynamic fracture toughness Ksub(Id)sup(opt). This overestimation becomes larger for larger specimen sizes and larger impact velocities. The results demonstrate the dominating influence inertia effects can have on hammer load measurements and emphasize the importance of eliminating these effects in order to determine non-erroneous dynamic fracture toughness values. (orig.)
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International Nuclear Information System (INIS)
Zhang, Long; Shi, Songting; Zhang, Juan; Zhou, Fangfang; Dijke, Peter ten
2012-01-01
Highlights: ► Expression of Id3 but not Id1 is induced by Wnt3a stimulation in C2C12 cells. ► Wnt3a induces Id3 expression via canonical Wnt/β-catenin pathway. ► Wnt3a-induced Id3 expression does not depend on BMP signaling activation. ► Induction of Id3 expression is critical determinant in Wnt3a-induced cell proliferation and differentiation. -- Abstract: Canonical Wnt signaling plays important roles in regulating cell proliferation and differentiation. In this study, we report that inhibitor of differentiation (Id)3 is a Wnt-inducible gene in mouse C2C12 myoblasts. Wnt3a induced Id3 expression in a β-catenin-dependent manner. Bone morphogenetic protein (BMP) also potently induced Id3 expression. However, Wnt-induced Id3 expression occurred independent of the BMP/Smad pathway. Functional studies showed that Id3 depletion in C2C12 cells impaired Wnt3a-induced cell proliferation and alkaline phosphatase activity, an early marker of osteoblast cells. Id3 depletion elevated myogenin induction during myogenic differentiation and partially impaired Wnt3a suppressed myogenin expression in C2C12 cells. These results suggest that Id3 is an important Wnt/β-catenin induced gene in myoblast cell fate determination.
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The McDonald Observatory Faint Comet Survey - Gas production in 17 comets
Cochran, Anita L.; Barker, Edwin S.; Ramseyer, Tod F.; Storrs, Alex D.
1992-01-01
The complete Intensified Dissector Scanner data set on 17 comets is presented, and production rates are derived and analyzed. It is shown that there is a strong degree of homogenization in the production rate ratios of many comets. It also appears that the ratio of the production rates of the various species has no heliocentric distance dependence, except for the case of NH2. When speaking of the gas in the coma of a comet, it appears that comets must have been formed under remarkably uniform conditions, and that they must have evolved and formed their comae in a similar manner. The data presented here constitute strong evidence that the minor species must be bound up in a lattice and that the interior of a comet must be reasonably uniform.
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Extending the McDonald Observatory Serendipitous Survey of UV/Blue Asteroid Spectra
Vilas, Faith; Cochran, A. L.
1999-01-01
Moderate resolution asteroid spectra in the 350 - 650 nm spectral range acquired randomly over many years (Cochran and Vilas, Icarus v 127, 121, 1997) identified absorption features in spectra of some of the asteroids. A feature centered at 430 nm was identified in the spectra of some low-albedo asteroids (C class and subclass), similar to the feature identified by Vilas et al. (Icarus, v. 102, 225,1993) in other low-albedo asteroid spectra and attributed to a ferric iron spin-forbidden transition in iron alteration minerals such as jarosite. Features at 505 nm and 430 nm were identified in the spectrum of 4 Vesta. The 505-nm feature is highly diagnostic of the amount and form of calcium in pyroxenes. This suggested further research on the sharpness and spectral placement of this feature in the spectra of Vesta and Vestoids (e.g., Cochran and Vilas, Icarus v. 134, 207, 1998). In 1997 and 1998, additional UV/blue spectra were obtained at the 2.7-m Harlan J. Smith telescope with a facility cassegrain spectrograph. These included spectra of low-albedo asteroids, the R-class asteroid 349 Dembowska, and the M-class asteroid 135 Hertha. These spectra will be presented and identified features will be discussed.
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Plesníková, Tereza
2012-01-01
The Bachelor's Thesis is focused on cultural and business practices of the United States of America and the Czech Republic. The main goal is to thoroughly examine all the differences in the mentality of these nations using Hofstede's cultural dimensions, and then illustrate these findings on the implementation of marketing and business strategy of McDonald's company. The thesis is concluded by specific examples of marketing and sales campaigns that took place in these two regions.
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DNA origami-based shape IDs for single-molecule nanomechanical genotyping
Zhang, Honglu; Chao, Jie; Pan, Dun; Liu, Huajie; Qiang, Yu; Liu, Ke; Cui, Chengjun; Chen, Jianhua; Huang, Qing; Hu, Jun; Wang, Lianhui; Huang, Wei; Shi, Yongyong; Fan, Chunhai
2017-04-01
Variations on DNA sequences profoundly affect how we develop diseases and respond to pathogens and drugs. Atomic force microscopy (AFM) provides a nanomechanical imaging approach for genetic analysis with nanometre resolution. However, unlike fluorescence imaging that has wavelength-specific fluorophores, the lack of shape-specific labels largely hampers widespread applications of AFM imaging. Here we report the development of a set of differentially shaped, highly hybridizable self-assembled DNA origami nanostructures serving as shape IDs for magnified nanomechanical imaging of single-nucleotide polymorphisms. Using these origami shape IDs, we directly genotype single molecules of human genomic DNA with an ultrahigh resolution of ~10 nm and the multiplexing ability. Further, we determine three types of disease-associated, long-range haplotypes in samples from the Han Chinese population. Single-molecule analysis allows robust haplotyping even for samples with low labelling efficiency. We expect this generic shape ID-based nanomechanical approach to hold great potential in genetic analysis at the single-molecule level.
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Spectroscopy of QSO candidates from the Jodrell Bank 966 MHz survey
International Nuclear Information System (INIS)
Walsh, D.; Wills, B.J.; Wills, D.
1979-01-01
Forty-two QSO candidates from the Jodrell Bank 966 MHz survey have been observed spectroscopically at McDonald Observatory. Twenty-five are confirmed as QSOs, and redshifts are given for 19 of them. Two objects are compact galaxies, and another probably is; redshifts are given for these. Seven objects are stars. Of the remaining seven objects, six are probably QSOs and one is probably a star. (author)
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Remote observatories for amateur astronomers using high-powered telescopes from home
Hubbell, Gerald R; Billard, Linda M
2015-01-01
Amateur astronomers who want to enhance their capabilities to contribute to science need look no farther than this guide to using remote observatories. The contributors cover how to build your own remote observatory as well as the existing infrastructure of commercial networks of remote observatories that are available to the amateur. They provide specific advice on which programs to use based on your project objectives and offer practical project suggestions. Remotely controlled observatories have many advantages—the most obvious that the observer does not have to be physically present to carry out observations. Such an observatory can also be used more fully because its time can be scheduled and usefully shared among several astronomers working on different observing projects. More and more professional-level observatories are open to use by amateurs in this way via the Internet, and more advanced amateur astronomers can even build their own remote observatories for sharing among members of a society ...
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MMS Observatory TV Results Contamination Summary
Rosecrans, Glenn; Brieda, Lubos; Errigo, Therese
2014-01-01
The Magnetospheric Multiscale (MMS) mission is a constellation of 4 observatories designed to investigate the fundamental plasma physics of reconnection in the Earth's magnetosphere. The various instrument suites measure electric and magnetic fields, energetic particles, and plasma composition. Each spacecraft has undergone extensive environmental testing to prepare it for its minimum 2 year mission. In this paper, we report on the extensive thermal vacuum testing campaign. The testing was performed at the Naval Research Laboratory utilizing the "Big Blue" vacuum chamber. A total of ten thermal vacuum tests were performed, including two chamber certifications, three dry runs, and five tests of the individual MMS observatories. During the test, the observatories were enclosed in a thermal enclosure known as the "hamster cage". The enclosure allowed for a detailed thermal control of various observatory zone, but at the same time, imposed additional contamination and system performance requirements. The environment inside the enclosure and the vacuum chamber was actively monitored by several QCMs, RGA, and up to 18 ion gauges. Each spacecraft underwent a bakeout phase, which was followed by 4 thermal cycles. Unique aspects of the TV campaign included slow pump downs with a partial represses, thruster firings, Helium identification, and monitoring pressure spikes with ion gauges. Selected data from these TV tests is presented along with lessons learned.
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Role of ID Proteins in BMP4 Inhibition of Profibrotic Effects of TGF-β2 in Human TM Cells.
Mody, Avani A; Wordinger, Robert J; Clark, Abbot F
2017-02-01
Increased expression of TGF-β2 in primary open-angle glaucoma (POAG) aqueous humor (AH) and trabecular meshwork (TM) causes deposition of extracellular matrix (ECM) in the TM and elevated IOP. Bone morphogenetic proteins (BMPs) regulate TGF-β2-induced ECM production. The underlying mechanism for BMP4 inhibition of TGF-β2-induced fibrosis remains undetermined. Bone morphogenic protein 4 induces inhibitor of DNA binding proteins (ID1, ID3), which suppress transcription factor activities to regulate gene expression. Our study will determine whether ID1and ID3 proteins are downstream targets of BMP4, which attenuates TGF-β2 induction of ECM proteins in TM cells. Primary human TM cells were treated with BMP4, and ID1 and ID3 mRNA, and protein expression was determined by quantitative PCR (Q-PCR) and Western immunoblotting. Intracellular ID1 and ID3 protein localization was studied by immunocytochemistry. Transformed human TM cells (GTM3 cells) were transfected with ID1 or ID3 expression vectors to determine their potential inhibitory effects on TGF-β2-induced fibronectin and plasminogen activator inhibitor-I (PAI-1) protein expression. Basal expression of ID1-3 was detected in primary human TM cells. Bone morphogenic protein 4 significantly induced early expression of ID1 and ID3 mRNA (P protein in primary TM cells, and a BMP receptor inhibitor blocked this induction. Overexpression of ID1 and ID3 significantly inhibited TGF-β2-induced expression of fibronectin and PAI-1 in TM cells (P protein 4 induced ID1 and ID3 expression suppresses TGF-β2 profibrotic activity in human TM cells. In the future, targeting specific regulators may control the TGF-β2 profibrotic effects on the TM, leading to disease modifying IOP lowering therapies.
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An enhanced dynamic ID-based authentication scheme for telecare medical information systems
Directory of Open Access Journals (Sweden)
Ankita Chaturvedi
2017-01-01
Full Text Available The authentication schemes for telecare medical information systems (TMIS try to ensure secure and authorized access. ID-based authentication schemes address secure communication, but privacy is not properly addressed. In recent times, dynamic ID-based remote user authentication schemes for TMIS have been presented to protect user’s privacy. The dynamic ID-based authentication schemes efficiently protect the user’s privacy. Unfortunately, most of the existing dynamic ID-based authentication schemes for TMIS ignore the input verifying condition. This makes login and password change phases inefficient. Inefficiency of the password change phase may lead to denial of service attack in the case of incorrect input in the password change phase. To overcome these weaknesses, we proposed a new dynamic ID-based authentication scheme using a smart card. The proposed scheme can quickly detect incorrect inputs which makes the login and password change phase efficient. We adopt the approach with the aim to protect privacy, and efficient login and password change phases. The proposed scheme also resists off-line password guessing attack and denial of service attack. We also demonstrate the validity of the proposed scheme by utilizing the widely-accepted BAN (Burrows, Abadi, and Needham logic. In addition, our scheme is comparable in terms of the communication and computational overheads with relevant schemes for TMIS.
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Automatic spent fuel ID number reader (I)
International Nuclear Information System (INIS)
Tanabe, S.; Kawamoto, H.; Fujimaki, K.; Kobe, A.
1991-01-01
An effective and efficient technique has been developed for facilitating identification works of LWR spent fuel stored in large scale spent fuel storage pools of such as processing plants. Experience shows that there are often difficulties in the implementation of operator's nuclear material accountancy and control works as well as safeguards inspections conducted on spent fuel assemblies stored in deep water pool. This paper reports that the technique is realized as an automatic spent fuel ID number reader system installed on fuel handling machine. The ID number reader system consists of an optical sub-system and an image processing sub-system. Thousands of spent fuel assemblies stored in under water open racks in each storage pool could be identified within relatively short time (e.g. within several hours) by using this combination. Various performance tests were carried out on image processing sub-system in 1990 using TV images obtained from different types of spent fuel assemblies stored in various storage pools of PWR and BWR power stations
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Cloning and shake flask expression of hrIDS- Like in Pichia pastoris ...
African Journals Online (AJOL)
The human Iduronate-2-sulfate sulfatase (hIDS-Like) was cloned into the methylotrophic yeast Pichia pastoris under the control of alcohol oxidase promoter (AOX1) and the -mating factor signal peptide (a-factor). Six clones were identified by PCR. Using clone IDS28, the enzyme was secreted into the culture medium, ...
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Regulation of trans fats: the gap, the Polder, and McDonald's French fries.
Katan, Martijn B
2006-05-01
Lowering the intake of trans fatty acids (TFA) probably reduces the incidence of coronary heart disease. Estimates of the reduction vary from 4% based on changes in plasma LDL and HDL concentrations alone, to > 20% based on epidemiological associations when TFA intake is lowered by 2% of energy (5 g/day). Even the lowest estimate represents enough cases to justify measures to reduce TFA intake. In The Netherlands, a major reduction in TFA content of retail foods has been achieved in the 1990s through efforts of industry; government intervention has been minimal. Societal pressure is now helping to reduce the TFA content of fast foods. McDonald's French fries in The Netherlands now have less than 4% trans and 24% saturates, as opposed to 21% trans and 21% saturates in the USA. This illustrates the feasibility of reducing TFA in fast foods without increasing saturates. As a result of these developments, dairy and meat have become the major remaining source of TFA in Europe. The question whether these ruminant TFA have the same effect on coronary heart disease risk as industrial TFA has not been settled.
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Educating for the Preservation of Dark Skies
Preston, Sandra Lee; Cianciolo, Frank; Wetzel, Marc; Finkelstein, Keely; Wren, William; Nance, Craig
2015-08-01
The stars at night really are big and bright deep in the heart of Texas at the McDonald Observatory near Fort Davis, Texas. Each year 80,000 visitors from all over the world make the pilgrimage to the Observatory to attend one of the three-times-a-week star parties. Many experience, for the first time, the humbling, splendor of a truly dark night sky. Over the last several years, the Observatory has experienced dramatic increases in visitation demonstrating the public’s appetite for science education, in general, and interest in the night sky, in particular. This increasing interest in astronomy is, ironically, occurring at a time when most of humanity’s skies are becoming increasingly light-polluted frustrating this natural interest. Dark skies and knowledgeable education and outreach staff are an important resource in maintaining the public’s interest in astronomy, support for astronomical research, and local tourism.This year Observatory educators were inspired by the observance of the International Year of Light to promote healthy outdoor lighting through its popular Astronomy Day distance learning program. This program reaches tens of thousands of K-12 students in Texas and other states with a message of how they can take action to preserve dark skies. As well, more than a thousand Boy Scouts visiting during the summer months receive a special program, which includes activities focusing on good lighting practices, thereby earning them credits toward an astronomy badge.The Observatory also offers a half-a-dozen K-12 teacher professional development workshops onsite each year, which provide about 90 teachers with dark skies information, best-practice lighting demonstrations, and red flashlights. Multi-year workshops for National Park and State of Texas Parks personnel are offered on dark sky preservation and sky interpretation at McDonald and a Dark Skies fund for retrofitting lights in the surrounding area has been established. The Observatory also uses
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Urania in the Marketplace: Observatories as Holiday Destinations
Rumstay, Kenneth S.
2015-01-01
During the twentieth century astronomical imagery was frequently incorporated, by manufacturers of industrial and consumer goods, into advertisements which appeared in popular magazines in America. The domes and telescopes of major observatories were often featured. In some cases, particularly within the Golden State of California, major astronomical facilities (notably the Lick and Mt. Wilson Observatories) were touted as tourist attractions and were publicized as such by tourist bureaus, railroads, and hotels.A particularly interesting example is provided by the Hotel Vendome in San Jose. With completion of the Lick Observatory (and the 36-inch Great Refractor) in 1887, the local business community felt that the city needed a first-class resort hotel. The architectural firm of Jacob Lenzen & Son was hired to design a grand hotel, comparable to those found in locales such as Monterey and Pasadena. The resulting four-story, 150-room structure cost 250,000, a phenomenal sum in those days. Yet, within just fourteen years, tourist demand led to the construction of a 36-room annex. Of course, a great resort hotel would not be complete without the opportunity for excursion, and the Mt. Hamilton Stage Company offered daily trips to the famous Lick Observatory.Farther south, the Mt. Wilson Observatory began construction of its own hotel in 1905.The original structure was destroyed by fire in 1913, and replaced by a second which was used by visitors until 1966.Early examples of advertisements for these observatories, recalling the heyday of astronomical tourism, are presented. A few more recent ones for Arecibo and Palomar are included for comparison.
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Saint Petersburg magnetic observatory: from Voeikovo subdivision to INTERMAGNET certification
Sidorov, Roman; Soloviev, Anatoly; Krasnoperov, Roman; Kudin, Dmitry; Grudnev, Andrei; Kopytenko, Yury; Kotikov, Andrei; Sergushin, Pavel
2017-11-01
Since June 2012 the Saint Petersburg magnetic observatory is being developed and maintained by two institutions of the Russian Academy of Sciences (RAS) - the Geophysical Center of RAS (GC RAS) and the Saint Petersburg branch of the Pushkov Institute of Terrestrial Magnetism, Ionosphere and Radio Wave Propagation of RAS (IZMIRAN SPb). On 29 April 2016 the application of the Saint Petersburg observatory (IAGA code SPG) for introduction into the INTERMAGNET network was accepted after approval by the experts of the first definitive dataset over 2015, produced by the GC RAS, and on 9 June 2016 the SPG observatory was officially certified. One of the oldest series of magnetic observations, originating in 1834, was resumed in the 21st century, meeting the highest quality standards and all modern technical requirements. In this paper a brief historical and scientific background of the SPG observatory foundation and development is given, the stages of its renovation and upgrade in the 21st century are described, and information on its current state is provided. The first results of the observatory functioning are discussed and geomagnetic variations registered at the SPG observatory are assessed and compared with geomagnetic data from the INTERMAGNET observatories located in the same region.
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Saint Petersburg magnetic observatory: from Voeikovo subdivision to INTERMAGNET certification
Directory of Open Access Journals (Sweden)
R. Sidorov
2017-11-01
Full Text Available Since June 2012 the Saint Petersburg magnetic observatory is being developed and maintained by two institutions of the Russian Academy of Sciences (RAS – the Geophysical Center of RAS (GC RAS and the Saint Petersburg branch of the Pushkov Institute of Terrestrial Magnetism, Ionosphere and Radio Wave Propagation of RAS (IZMIRAN SPb. On 29 April 2016 the application of the Saint Petersburg observatory (IAGA code SPG for introduction into the INTERMAGNET network was accepted after approval by the experts of the first definitive dataset over 2015, produced by the GC RAS, and on 9 June 2016 the SPG observatory was officially certified. One of the oldest series of magnetic observations, originating in 1834, was resumed in the 21st century, meeting the highest quality standards and all modern technical requirements. In this paper a brief historical and scientific background of the SPG observatory foundation and development is given, the stages of its renovation and upgrade in the 21st century are described, and information on its current state is provided. The first results of the observatory functioning are discussed and geomagnetic variations registered at the SPG observatory are assessed and compared with geomagnetic data from the INTERMAGNET observatories located in the same region.
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From research institution to astronomical museum: a history of the Stockholm Observatory
Yaskell, Steven Haywood
2008-07-01
The Royal Swedish Academy of Sciences (RSAS) (or Kungliga Vetenskapsakademien [KvA] in Swedish) founded 1739, opened its first permanent building, an astronomical and meteorological observatory, on 20 September 1753. This was situated at Brunkebergsåsen (formerly Observatorie Lunden, or Observatory Hill), on a high terrace in a northern quarter of Stockholm. This historic building is still sometimes called Gamla Observatoriet (the Old Observatory) and now is formally the Observatory Museum. This paper reviews the history of the Observatory from its function as a scientific astronomical institution to its relatively-recent relegation to museum status.
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Astronomical Research Using Virtual Observatories
Directory of Open Access Journals (Sweden)
M Tanaka
2010-01-01
Full Text Available The Virtual Observatory (VO for Astronomy is a framework that empowers astronomical research by providing standard methods to find, access, and utilize astronomical data archives distributed around the world. VO projects in the world have been strenuously developing VO software tools and/or portal systems. Interoperability among VO projects has been achieved with the VO standard protocols defined by the International Virtual Observatory Alliance (IVOA. As a result, VO technologies are now used in obtaining astronomical research results from a huge amount of data. We describe typical examples of astronomical research enabled by the astronomical VO, and describe how the VO technologies are used in the research.
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The South African Astronomical Observatory
International Nuclear Information System (INIS)
1989-01-01
The research work discussed in this report covers a wide range, from work on the nearest stars to studies of the distant quasars, and the astronomers who have carried out this work come from universities and observatories spread around the world as well as from South African universities and from the South African Astronomical Observatory (SAAO) staff itself. A characteristic of much of this work has been its collaborative character. SAAO studies in 1989 included: supernovae 1987A; galaxies; ground-based observations of celestial x-ray sources; the Magellanic Clouds; pulsating variables; galactic structure; binary star phenomena; the provision of photometric standards; nebulous matter; stellar astrophysics, and astrometry
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Zircaloy cladding ID/OD oxidation studies. Final report
International Nuclear Information System (INIS)
Westerman, R.E.; Hesson, G.M.
1977-11-01
The ID/OD oxide ratio that forms on Zircaloy tubing at temperatures relevant to postulated LOCA conditions was measured as a function of time, temperature, and distance from the rupture. The average ratio at the rupture position was less than unity, and decreased with decreasing test time and increasing distance from the point of rupture. The maximum observed ID/OD oxide ratio was 1.4. Ratios in excess of unity were typically found to be a consequence of the OD oxide being thinner than would have been anticipated from the nominal test conditions. Confirmatory data were also obtained on the isothermal oxidation kinetics of Zircaloy. These data are in good agreement with those obtained by other investigators and confirm the conservative nature of the Baker-Just equation that is required for use in licensing calculations
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The Lowell Observatory Predoctoral Fellowship Program
Prato, Lisa A.; Shkolnik, E.
2014-01-01
Lowell Observatory is pleased to solicit applications for our Predoctoral Fellowship Program. Now beginning its seventh year, this program is designed to provide unique research opportunities to graduate students in good standing, currently enrolled at Ph.D. granting institutions. Lowell staff research spans a wide range of topics, from astronomical instrumentation, to icy bodies in our solar system, exoplanet science, stellar populations, star formation, and dwarf galaxies. The Observatory's new 4.3 meter Discovery Channel Telescope has successfully begun science operations and we anticipate the commissioning of several new instruments in 2014, making this a particularly exciting time to do research at Lowell. Student research is expected to lead to a thesis dissertation appropriate for graduation at the doctoral level at the student's home institution. The Observatory provides competitive compensation and full benefits to student scholars. For more information, see http://www2.lowell.edu/rsch/predoc.php and links therein. Applications for Fall 2014 are due by May 1, 2014.
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Multinational History of Strasbourg Astronomical Observatory
Heck, André
2005-01-01
Strasbourg Astronomical Observatory is quite an interesting place for historians: several changes of nationality between France and Germany, high-profile scientists having been based there, big projects born or installed in its walls, and so on. Most of the documents circulating on the history of the Observatory and on related matters have however been so far poorly referenced, if at all. This made necessary the compilation of a volume such as this one, offering fully-documented historical facts and references on the first decades of the Observatory history, authored by both French and German specialists. The experts contributing to this book have done their best to write in a way understandable to readers not necessarily hyperspecialized in astronomy nor in the details of European history. After an introductory chapter by the Editor, contributions by Wolfschmidt and by Duerbeck respectively deal extensively with the German periods and review people and instrumentation, while another paper by Duerbeck is more...
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Electricity and gas market observatory 1. Quarter 2009
International Nuclear Information System (INIS)
2009-01-01
The purpose of the observatory is to provide the general public with indicators for monitoring market deregulation. It both covers the wholesale and retail electricity and gas markets in Metropolitan France. This observatory is updated every three months and data are available on CRE web site (www.cre.fr). Since the 1. of July 2007, all customers can choose their gas and electricity suppliers. Content: A - The electricity market: The retail electricity market (Introduction, Customer segments and their respective weight, Status on March 31, 2009, Dynamic analysis: 1. Quarter 2009), The wholesale electricity market (Introduction, Wholesale market activity in France, Prices on the French wholesale market and European comparison, Import and export volumes, Concentration of the French electricity market). B - The gas market: The retail gas market (Introduction, Customer segments and their respective weight, Status on March 31. 2009, Dynamic analysis: 1. Quarter 2009), The wholesale gas market (Main steps in the French Wholesale gas market, Gas pricing and gas markets in Europe, The wholesale market in France, Prices on the French wholesale market and European comparison, Concentration of the French gas market) C - Appendices: Electricity and gas market observatories combined glossary, Specific electricity market observatory glossary, Specific gas market observatory glossary
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Electricity and gas market observatory. 2. quarter 2007
International Nuclear Information System (INIS)
2007-01-01
Since July 1, 2004, all electricity and gas consumers can be eligible according to their consumption site, as long as all or part of the electricity or gas consumed is designed for non-residential use. The purpose of the observatory is to provide the general public with indicators for monitoring market deregulation. It both covers the wholesale and retail electricity and gas markets in Metropolitan France. This observatory is updated every three months and data are available on CRE web-site (www.cre.fr). It presents: The electricity market; The retail electricity market: Non-residential customer segments and their respective weights, Status at July 1, 2007, Dynamic analysis: 2. Quarter 2007; The wholesale electricity market: Wholesale market activity in France, Prices on the French wholesale market and European comparison, Import and export volumes, Concentration of the French electricity market, Striking facts of the second quarter 2007; The gas market; The retail gas market: The non-residential customer segments and their respective weights, Status at July 1. 2007; The wholesale gas market: Gas pricing and gas markets in Europe,The wholesale market in France. Some glossaries are attached to the document: Electricity and gas market observatories combined glossary; Specific electricity market observatory glossary; Specific gas market observatory glossary
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Electricity and gas market observatory. 1. quarter 2007
International Nuclear Information System (INIS)
2007-01-01
Since July 1, 2004, all electricity and gas consumers can be eligible according to their consumption site, as long as all or part of the electricity or gas consumed is designed for non-residential use. The purpose of the observatory is to provide the general public with indicators for monitoring market deregulation. It both covers the wholesale and retail electricity and gas markets in Metropolitan France. This observatory is updated every three months and data are available on CRE web-site (www.cre.fr). It presents: The electricity market; The retail electricity market: Eligible customer segments and their respective weights, Status at April 1, 2007, Dynamic analysis: 1. Quarter 2007; The wholesale electricity market: Traded volumes on the French wholesale electricity market and comparison with European markets, Prices on the French wholesale electricity market and European comparison, Import and export volumes, Concentration of the French electricity market, Striking facts of the 1. 2007 quarter; The gas market; The retail gas market: The eligible customer segments and their respective weights, Status at April 1. 2007; The wholesale gas market: Gas pricing and gas markets in Europe,The wholesale market in France. Some glossaries are attached to the document: Electricity and gas market observatories combined glossary; Specific electricity market observatory glossary; Specific gas market observatory glossary
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Electricity and gas market observatory. 4. quarter 2006
International Nuclear Information System (INIS)
2007-01-01
Since July 1, 2004, all electricity and gas consumers can be eligible according to their consumption site, as long as all or part of the electricity or gas consumed is designed for non-residential use. The purpose of the observatory is to provide the general public with indicators for monitoring market deregulation. It both covers the wholesale and retail electricity and gas markets in Metropolitan France. This observatory is updated every three months and data are available on CRE web-site (www.cre.fr). It presents: The electricity market; The retail electricity market: Eligible customer segments and their respective weights, Status at January 1, 2007, Dynamic analysis: 4. Quarter 2007; The wholesale electricity market: Traded volumes on the French wholesale electricity market and comparison with European markets, Prices on the French wholesale electricity market and European comparison, Import and export volumes, Concentration of the French electricity market, Striking facts of the 4. 2006 quarter; The gas market; The retail gas market: The eligible customer segments and their respective weights, Status at January 1. 2007; The wholesale gas market: Gas pricing and gas markets in Europe,The wholesale market in France. Some glossaries are attached to the document: Electricity and gas market observatories combined glossary; Specific electricity market observatory glossary; Specific gas market observatory glossary
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Electricity and gas market observatory. 2. quarter 2007
Energy Technology Data Exchange (ETDEWEB)
NONE
2007-07-01
Since July 1, 2004, all electricity and gas consumers can be eligible according to their consumption site, as long as all or part of the electricity or gas consumed is designed for non-residential use. The purpose of the observatory is to provide the general public with indicators for monitoring market deregulation. It both covers the wholesale and retail electricity and gas markets in Metropolitan France. This observatory is updated every three months and data are available on CRE web-site (www.cre.fr). It presents: The electricity market; The retail electricity market: Non-residential customer segments and their respective weights, Status at July 1, 2007, Dynamic analysis: 2. Quarter 2007; The wholesale electricity market: Wholesale market activity in France, Prices on the French wholesale market and European comparison, Import and export volumes, Concentration of the French electricity market, Striking facts of the second quarter 2007; The gas market; The retail gas market: The non-residential customer segments and their respective weights, Status at July 1. 2007; The wholesale gas market: Gas pricing and gas markets in Europe,The wholesale market in France. Some glossaries are attached to the document: Electricity and gas market observatories combined glossary; Specific electricity market observatory glossary; Specific gas market observatory glossary.
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Electricity and gas market observatory. 1. quarter 2007
Energy Technology Data Exchange (ETDEWEB)
NONE
2007-07-01
Since July 1, 2004, all electricity and gas consumers can be eligible according to their consumption site, as long as all or part of the electricity or gas consumed is designed for non-residential use. The purpose of the observatory is to provide the general public with indicators for monitoring market deregulation. It both covers the wholesale and retail electricity and gas markets in Metropolitan France. This observatory is updated every three months and data are available on CRE web-site (www.cre.fr). It presents: The electricity market; The retail electricity market: Eligible customer segments and their respective weights, Status at April 1, 2007, Dynamic analysis: 1. Quarter 2007; The wholesale electricity market: Traded volumes on the French wholesale electricity market and comparison with European markets, Prices on the French wholesale electricity market and European comparison, Import and export volumes, Concentration of the French electricity market, Striking facts of the 1. 2007 quarter; The gas market; The retail gas market: The eligible customer segments and their respective weights, Status at April 1. 2007; The wholesale gas market: Gas pricing and gas markets in Europe,The wholesale market in France. Some glossaries are attached to the document: Electricity and gas market observatories combined glossary; Specific electricity market observatory glossary; Specific gas market observatory glossary.
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Electricity and gas market observatory. 4. quarter 2006
Energy Technology Data Exchange (ETDEWEB)
NONE
2007-07-01
Since July 1, 2004, all electricity and gas consumers can be eligible according to their consumption site, as long as all or part of the electricity or gas consumed is designed for non-residential use. The purpose of the observatory is to provide the general public with indicators for monitoring market deregulation. It both covers the wholesale and retail electricity and gas markets in Metropolitan France. This observatory is updated every three months and data are available on CRE web-site (www.cre.fr). It presents: The electricity market; The retail electricity market: Eligible customer segments and their respective weights, Status at January 1, 2007, Dynamic analysis: 4. Quarter 2007; The wholesale electricity market: Traded volumes on the French wholesale electricity market and comparison with European markets, Prices on the French wholesale electricity market and European comparison, Import and export volumes, Concentration of the French electricity market, Striking facts of the 4. 2006 quarter; The gas market; The retail gas market: The eligible customer segments and their respective weights, Status at January 1. 2007; The wholesale gas market: Gas pricing and gas markets in Europe,The wholesale market in France. Some glossaries are attached to the document: Electricity and gas market observatories combined glossary; Specific electricity market observatory glossary; Specific gas market observatory glossary.
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Alía, P; Mañá, J; Capdevila, O; Alvarez, A; Navarro, M A
2005-01-01
Serum angiotensin converting enzyme (SACE) concentration is considered a marker of sarcoidosis activity. This concentration is influenced by an insertion/deletion (I/D) polymorphism of the ACE gene, such that SACE levels follow the pattern DD>ID>II. The aim of our work was to study the relationship between I/D polymorphism and susceptibility to sarcoidosis, as well as the relation between this polymorphism and the clinical presentation and evolution of the disease in 177 sarcoidosis patients. A group of 104 individuals without sarcoidosis was included as control. Genotyping was done by a polymerase chain reaction (PCR) method, and SACE concentration at diagnosis was determined by a kinetic method. No differences were observed in genotype or allele distributions between patients and controls, nor between patients considering the type of presentation (Löfgren versus non-Löfgren) and evolution of the disease (acute versus chronic). As reported for healthy populations, SACE concentrations followed the pattern DD>ID>II in sarcoidosis patients, but significant differences between genotypes existed only in the Löfgren group (p = 0.003) and in acute patients (p = 0.02). SACE concentrations at diagnosis were lower in acute patients (p = 0.05) and in Löfgren's syndrome (p = 0.04), but this seemed to occur only in ID individuals (p = 0.02 and p = 0.01, respectively). No relation was thus found between I/D polymorphism and susceptibility to sarcoidosis, but ACE I/D genotyping may improve the assessment of disease activity, both at diagnosis and during the follow-up of treated and untreated patients.
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Identification of an active ID-like group of SINEs in the mouse.
Kass, David H; Jamison, Nicole
2007-09-01
The mouse genome consists of five known families of SINEs: B1, B2, B4/RSINE, ID, and MIR. Using RT-PCR we identified a germ-line transcript that demonstrates 92.7% sequence identity to ID (excluding primer sequence), yet a BLAST search identified numerous matches of 100% sequence identity. We analyzed four of these elements for their presence in orthologous genes in strains and subspecies of Mus musculus as well as other species of Mus using a PCR-based assay. All four analyzed elements were identified either only in M. musculus or exclusively in both M. musculus and M. domesticus, indicative of recent integrations. In conjunction with the identification of transcripts, we present an active ID-like group of elements that is not derived from the proposed BC1 master gene of ID elements. A BLAST of the rat genome indicated that these elements were not in the rat. Therefore, this family of SINEs has recently evolved, and since it has thus far been observed mainly in M. musculus, we refer to this family as MMIDL.
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RPD: Reusable Pseudo-Id Distribution for a Secure and Privacy Preserving VANET
Directory of Open Access Journals (Sweden)
Sulaiman Ashraph
2013-08-01
Full Text Available In any VANET, security and privacy are the two fundamental issues. Obtaining efficient security in vehicular communication is essential without compromising privacy-preserving mechanisms. Designing a suitable protocol for VANET by having these two issues in mind is challenging because efficiency, unlinkablity and traceability are the three qualities having contradictions between them. In this paper, we introduce an efficient Reusable Pseudo-id Distribution (RPD scheme. The Trusted Authority (TA designating the Road Side Units (RSUs to generate n reusable pseudo ids and distribute them to the On Board Units (OBUs on request characterizes the proposed protocol. RSUs issue the aggregated hashes of all its valid pseudo-ids along with a symmetric shared key and a particular pseudo-id to each vehicle that enters into its coverage range. Through this the certificates attached to the messages can be eliminated and thus resulting in a significantly reduced packet size. The same anonymous keys can then be re-distributed by the RSUs episodically to other vehicles. We analyze the proposed protocol extensively to demonstrate its merits and efficiency.
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Demonstrating idAnimate : a multi-touch system for sketching and rapidly manipulating animations
Quevedo Fernandez, Javier; Martens, J.B.O.S.
2012-01-01
This demonstration presents idAnimate, a multi-touch application for sketching animations. Thanks to the affordances provided by multitouch interfaces, idAnimate yields a novel, intuitive and easy to use animation technique named transformation-by-example, that allows users to author animations in
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Directory of Open Access Journals (Sweden)
García-Carpintero, Esther
2014-06-01
Full Text Available The development and improvement of cooperation between the industrial sector and the public R&D system can produce competitive advantages for the companies. The present work describes experiences and perceptions of Spanish biotechnology companies in their collaboration with the public R&D system. Results show that almost all the biotechnological companies with R&D activities (93.6% have cooperated with the public R&D system. The main barriers found by the companies are the excess of bureaucracy and the slow response of public researchers. Results obtained also suggest the need to establish public policies and programmes to promote knowledge and technology transfer from public research centres to companies, with a special focus on encouraging researchers from the public R&D system and on improving how Technology Transfer Offices work.El desarrollo y la mejora de la cooperación entre el sector productivo y el sistema público de I+D puede generar un conjunto de ventajas competitivas para estas empresas. El presente trabajo describe las experiencias y percepciones de las empresas biotecnológicas españolas en su colaboración con el sistema público de I+D. Los resultados muestran que prácticamente la totalidad de empresas biotecnológicas españolas con actividades de I+D (un 93,6% han mantenido algún tipo de colaboración con el sistema público de I+D. Los principales obstáculos percibidos por estas empresas en su colaboración con el sistema público de I+D son el exceso de burocracia y la respuesta lenta de los investigadores. Los resultados obtenidos sugieren la conveniencia de establecer políticas y programas públicos para fomentar la transferencia de conocimiento y tecnología desde el sistema público de I+D a las empresas, fundamentalmente centrados en la necesidad de incentivar a los investigadores del sistema público de I+D y mejorar el funcionamiento de las Oficinas de Transferencia de Tecnología.
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Identifying clouds over the Pierre Auger Observatory using infrared satellite data
Energy Technology Data Exchange (ETDEWEB)
Abreu, Pedro; et al.,
2013-12-01
We describe a new method of identifying night-time clouds over the Pierre Auger Observatory using infrared data from the Imager instruments on the GOES-12 and GOES-13 satellites. We compare cloud identifications resulting from our method to those obtained by the Central Laser Facility of the Auger Observatory. Using our new method we can now develop cloud probability maps for the 3000 km^2 of the Pierre Auger Observatory twice per hour with a spatial resolution of ~2.4 km by ~5.5 km. Our method could also be applied to monitor cloud cover for other ground-based observatories and for space-based observatories.
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Governance of a regional observatory - Technical Guidebook nr. 6
International Nuclear Information System (INIS)
Bardinal, Marc; Blais, Thomas; Phillips, Celine; Girault, Maurice; Guedon, Matthieu; Kampetenga, Ghislaine; Mora, Lucie; Riey, Benedicte; Mairet, Nicolas; Falque-Masset, Marie-Laure
2011-06-01
Whereas survey is one of the key for action for local actors in the field of energy management and of struggle against climate change, setting up a regional observatory is a way to get an insight on energy consumptions and productions within a territory, and to follow-up its greenhouse gas emissions. Moreover, the Grenelle de l'Environnement imposed on communities, and firstly regions, new obligations for the follow-up and reduction of greenhouse gas emissions with the elaboration of Regional Climate Air Energy Schemes (SRCAE). This guide therefore aims at proposing a framework of objectives and missions for such a regional observatory of energy and emissions, and at illustrating the variety of possible models through a synthesis of regional arrangements. Thus, it presents and discusses general principles regarding the definition of objectives and missions of an observatory (objectives, functions, scope), the setting up and organisation of an observatory with its funding documents, and mobilised financial means and tools. It also presents what can be produced and published by these observatories
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The paradox of IDs: an account of an ethnographic experience in the US
Directory of Open Access Journals (Sweden)
Mariza Peirano
2008-01-01
Full Text Available In the modern world, IDs are indispensable objects, without which we cannot prove that we are who we say we are. We need material substantiation that attests to the authenticity of our self-identification. This paper is an account of an ethnographic experience about IDs and identification processes in the US, based on the examination of two events in which Eliot Spitzer, the New York State governor from January 2007 to March 2008, was a central figure. A comparison with the Brazilian scenario is present throughout the paper, and it ends by focusing on the ID theft phenomenon.
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NASA Names Premier X-Ray Observatory and Schedules Launch
1998-12-01
NASA's Advanced X-ray Astrophysics Facility has been renamed the Chandra X-ray Observatory in honor of the late Indian-American Nobel laureate, Subrahmanyan Chandrasekhar. The telescope is scheduled to be launched no earlier than April 8, 1999 aboard the Space Shuttle Columbia mission STS-93, commanded by astronaut Eileen Collins. Chandrasekhar, known to the world as Chandra, which means "moon" or "luminous" in Sanskrit, was a popular entry in a recent NASA contest to name the spacecraft. The contest drew more than six thousand entries from fifty states and sixty-one countries. The co-winners were a tenth grade student in Laclede, Idaho, and a high school teacher in Camarillo, CA. The Chandra X-ray Observatory Center (CXC), operated by the Smithsonian Astrophysical Observatory, will control science and flight operations of the Chandra X-ray Observatory for NASA from Cambridge, Mass. "Chandra is a highly appropriate name," said Harvey Tananbaum, Director of the CXC. "Throughout his life Chandra worked tirelessly and with great precision to further our understanding of the universe. These same qualities characterize the many individuals who have devoted much of their careers to building this premier X-ray observatory." "Chandra probably thought longer and deeper about our universe than anyone since Einstein," said Martin Rees, Great Britain's Astronomer Royal. "Chandrasekhar made fundamental contributions to the theory of black holes and other phenomena that the Chandra X-ray Observatory will study. His life and work exemplify the excellence that we can hope to achieve with this great observatory," said NASA Administrator Dan Goldin. Widely regarded as one of the foremost astrophysicists of the 20th century, Chandrasekhar won the Nobel Prize in 1983 for his theoretical studies of physical processes important to the structure and evolution of stars. He and his wife immigrated from India to the U.S. in 1935. Chandrasekhar served on the faculty of the University of
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Papaspyridonos, Marianna; Matei, Irina; Huang, Yujie; do Rosario Andre, Maria; Brazier-Mitouart, Helene; Waite, Janelle C; Chan, April S; Kalter, Julie; Ramos, Ilyssa; Wu, Qi; Williams, Caitlin; Wolchok, Jedd D; Chapman, Paul B; Peinado, Hector; Anandasabapathy, Niroshana; Ocean, Allyson J; Kaplan, Rosandra N; Greenfield, Jeffrey P; Bromberg, Jacqueline; Skokos, Dimitris; Lyden, David
2015-04-29
A central mechanism of tumour progression and metastasis involves the generation of an immunosuppressive 'macroenvironment' mediated in part through tumour-secreted factors. Here we demonstrate that upregulation of the Inhibitor of Differentiation 1 (Id1), in response to tumour-derived factors, such as TGFβ, is responsible for the switch from dendritic cell (DC) differentiation to myeloid-derived suppressor cell expansion during tumour progression. Genetic inactivation of Id1 largely corrects the myeloid imbalance, whereas Id1 overexpression in the absence of tumour-derived factors re-creates it. Id1 overexpression leads to systemic immunosuppression by downregulation of key molecules involved in DC differentiation and suppression of CD8 T-cell proliferation, thus promoting primary tumour growth and metastatic progression. Furthermore, advanced melanoma patients have increased plasma TGFβ levels and express higher levels of ID1 in myeloid peripheral blood cells. This study reveals a critical role for Id1 in suppressing the anti-tumour immune response during tumour progression and metastasis.
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A New Observatory for Eastern College: A Dream Realized
Bradstreet, D. H.
1996-12-01
The Eastern College Observatory began as a rooftop observing deck with one Celestron 8 telescope in 1976 as the workhorse instrument of the observational astronomy lab within the core curriculum. For 20 years the observing deck served as the crude observatory, being augmented through the years by other computerized Celestron 8's and a 17.5" diameter Dobsonian with computerized setting circles. The lab consisted primarily of visual observations and astrophotography. In 1987 plans were set into motion to raise money to build a permanent Observatory on the roof of the main classroom building. Fundraising efforts included three Jog-A-Thons (raising more than $40,000) and many donations from individuals and foundations. The fundraising was completed in 1996 and a two telescope observatory was constructed in the summer of 1996 complete with warm room, CCD cameras, computers, spectrograph, video network, and computerized single channel photometer. The telescopes are computerized 16" diameter Meade LX200 Schmidt-Cassegrains, each coupled to Gateway Pentium Pro 200 MHz computers. SBIG ST-8 CCD cameras were also secured for each telescope and an Optec SSP-7 photometer and Optomechanics Research 10C Spectrograph were also purchased. A Daystar H-alpha solar filter and Thousand Oaks visual light solar filter have expanded the Observatory's functionality to daytime observing as well. This is especially useful for the thousands of school children who frequent the Planetarium each year. The Observatory primarily serves the core astronomy lab where students must observe and photograph a prescribed number of celestial objects in a semester. Advanced students can take directed studies where they conduct photometry on eclipsing binaries or other variable stars or search for new asteroids. In addition, the Observatory and Planetarium are open to the public. Interested members of the community can reserve time on the telescopes and receive training and supervision from lab assistants
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miR-342 regulates BRCA1 expression through modulation of ID4 in breast cancer.
Directory of Open Access Journals (Sweden)
Elisabetta Crippa
Full Text Available A miRNAs profiling on a group of familial and sporadic breast cancers showed that miRNA-342 was significantly associated with estrogen receptor (ER levels. To investigate at functional level the role of miR-342 in the pathogenesis of breast cancer, we focused our attention on its "in silico" predicted putative target gene ID4, a transcription factor of the helix-loop-helix protein family whose expression is inversely correlated with that of ER. ID4 is expressed in breast cancer and can negatively regulate BRCA1 expression. Our results showed an inverse correlation between ID4 and miR-342 as well as between ID4 and BRCA1 expression. We functionally validated the interaction between ID4 and miR-342 in a reporter Luciferase system. Based on these findings, we hypothesized that regulation of ID4 mediated by miR-342 could be involved in the pathogenesis of breast cancer by downregulating BRCA1 expression. We functionally demonstrated the interactions between miR-342, ID4 and BRCA1 in a model provided by ER-negative MDA-MB-231 breast cancer cell line that presented high levels of ID4. Overexpression of miR-342 in these cells reduced ID4 and increased BRCA1 expression, supporting a possible role of this mechanism in breast cancer. In the ER-positive MCF7 and in the BRCA1-mutant HCC1937 cell lines miR-342 over-expression only reduced ID4. In the cohort of patients we studied, a correlation between miR-342 and BRCA1 expression was found in the ER-negative cases. As ER-negative cases were mainly BRCA1-mutant, we speculate that the mechanism we demonstrated could be involved in the decreased expression of BRCA1 frequently observed in non BRCA1-mutant breast cancers and could be implicated as a causal factor in part of the familial cases grouped in the heterogeneous class of non BRCA1 or BRCA2-mutant cases (BRCAx. To validate this hypothesis, the study should be extended to a larger cohort of ER-negative cases, including those belonging to the BRCAx class.
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Astronomy and astrophysics communication in the UCM Observatory
Crespo-Chacón, I.; de Castro, E.; Díaz, C.; Gallego, J.; Gálvez, M. C.; Hernán-Obispo, M.; López-Santiago, J.; Montes, D.; Pascual, S.; Verdet, A.; Villar, V.; Zamorano, J.
We present a summary of the last activities of science communication that have taken place in the Observatorio de la Universidad Complutense de Madrid (UCM Observatory) on the occasion of the Third Science Week of the Comunidad Autónoma de Madrid (3-16 November 2003), including guided tours through the observatory facilities, solar observations, and several talks. Moreover the current telescopes, instruments and tools of the UCM Observatory have allowed us to organize other communicating activities such as the live observation, together with its internet broadcast, of total lunar eclipses and other exceptional astronomical events as the Venus transit that took place in 8 June 2004.
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Boscovich and the Brera Observatory .
Antonello, E.
In the mid 18th century both theoretical and practical astronomy were cultivated in Milan by Barnabites and Jesuits. In 1763 Boscovich was appointed to the chair of mathematics of the University of Pavia in the Duchy of Milan, and the following year he designed an observatory for the Jesuit Collegium of Brera in Milan. The Specola was built in 1765 and it became quickly one of the main european observatories. We discuss the relation between Boscovich and Brera in the framework of a short biography. An account is given of the initial research activity in the Specola, of the departure of Boscovich from Milan in 1773 and his coming back just before his death.
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Id2 reinforces TH1 cell differentiation and inhibits E2A to repress TFH cell differentiation
Shaw, Laura A.; Bélanger, Simon; Omilusik, Kyla D.; Cho, Sunglim; Scott-Browne, James P.; Nance, J. Philip; Goulding, John; Lasorella, Anna; Lu, Li-Fan; Crotty, Shane; Goldrath, Ananda W.
2016-01-01
Differentiation of T helper (TH) effector subsets is critical for host protection. E protein transcription factors and Id proteins are important arbiters of T cell development, but their role in differentiation of TH1 and TFH cells is not well understood. TH1 cells showed robust Id2 expression compared to TFH cells, and RNAi depletion of Id2 increased TFH cell frequencies. Further, TH1 cell differentiation was blocked by Id2 deficiency, leading to E protein-dependent accumulation of effector cells with mixed characteristics during viral infection and severely impaired generation of TH1 cells following Toxoplasma gondii infection. The TFH-defining transcriptional repressor Bcl6 bound the Id2 locus, providing a mechanism for the bimodal Id2 expression and reciprocal development of TH1 and TFH cell fates. PMID:27213691
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Searching the Heavens and the Earth: This History of Jesuit Observatories
Udías, Agustín
2003-10-01
Jesuits established a large number of astronomical, geophysical and meteorological observatories during the 17th and 18th centuries and again during the 19th and 20th centuries throughout the world. The history of these observatories has never been published in a complete form. Many early European astronomical observatories were established in Jesuit colleges. During the 17th and 18th centuries Jesuits were the first western scientists to enter into contact with China and India. It was through them that western astronomy was first introduced in these countries. They made early astronomical observations in India and China and they directed for 150 years the Imperial Observatory of Beijing. In the 19th and 20th centuries a new set of observatories were established. Besides astronomy these now included meteorology and geophysics. Jesuits established some of the earliest observatories in Africa, South America and the Far East. Jesuit observatories constitute an often forgotten chapter of the history of these sciences. This volume is aimed at all scientists and students who do not want to forget the Jesuit contributions to science. Link: http://www.wkap.nl/prod/b/1-4020-1189-X
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Eisenman, Laura T.; Farley-Ripple, Elizabeth; Culnane, Mary; Freedman, Brian
2013-01-01
Social networks of persons with intellectual disabilities (ID) have been characterized as smaller and less diverse than those of typical peers. Advocates have focused on strengthening those social networks by expanding circles of social support, protection, and friendship. As young adults with ID experience increasing levels of community…
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Spectroscopic Classification of SN 2018nt as a Reddened Type Ia Supernova
Vinko, J.; Szeged, U.; Wheeler, J. C.
2018-02-01
An optical spectrum (range 360-700 nm) of SN 2018nt (K2 C16-0043), was obtained with the "Low Resolution Spectrograph-2" (LRS2) on the 10m Hobby-Eberly Telescope at McDonald Observatory by S. Odewahn on 2018 Feb 05.20 UT. The spectrum is consistent with that of a heavily reddened Type Ia supernova (with Av > 2 mag) about 3 weeks after maximum light.
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2013-01-04
... Services Group, Inc., Commercial/Actuarial/ Information Delivery Services (IDS)/Corporate & Financial... Assistance (TAA) applicable to workers and former workers of Hartford Financial Services Group, Inc., Commercial/ Actuarial/Information Delivery Services (IDS)/Corporate & Financial Reporting group, Hartford...
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Kang, Hui-Yuan; Wang, Xin-Rong; Gao, Li; Wang, Wei; Li, Mian-Yang; Wang, Li-Li; Wang, Cheng-Bin; Yu, Li
2015-04-01
To evaluate significance of ID4 gene mehtylation in demethylating myelodysplastic syndrome(MDS) cell Line MUTZ1 and 2 patients with MDS. The methylation-specific PCR (MS-PCR) and reverse transcription-PCR (RT-PCR) were applied to identify the methylation status and gene expression of ID4 gene in MDS cell line MUTZ1, a patient with aplastic anemia(AA) and a donor with normal bone marrow (NBM). RT-PCR was applied to detect the ID4 gene expression status in MUTZ1 cell line treated with decitabine at 3 different concentrations. Then bisulfite sequencing PCR (BSP) was applied to detect ID4 gene methylation status in 2 MDS parients treated with decitabine. The MDS cell line MUTZ-1 displayed a complete methylation of ID4 gene promoter with little mRNA expression. Inversely, bone marrow of an AA patient and NBM showed complete unmethylation of this gene with intensity mRNA expression. With the increase of decitabine concentration, ID4 gene mRNA expression was more and more increased. After decitabine treatment, ID4 gene methylation-positive frequencies of both the 2 MDS patients were much more decreased than that of the first treatment. So, ID4 gene mRNA expression inhibited by promoter hypemethylation could be recovered by using demethylation medicine. ID4 as a new potential anti-oncogene suggests that its methylation may become a marker for selection and assessment of therapeutic schedules in patients with MDS.
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Geomagnetic Observatory Database February 2004
National Oceanic and Atmospheric Administration, Department of Commerce — The NOAA National Centers for Environmental Information (formerly National Geophysical Data Center) maintains an active database of worldwide geomagnetic observatory...
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Astrophysical Sources of Cosmic Rays and Related Measurements with the Pierre Auger Observatory
Energy Technology Data Exchange (ETDEWEB)
Abraham, : J.; Abreu, P.; Aglietta, M.; Aguirre, C.; Ahn, E.J.; Allard, D.; Allekotte, I.; Allen, J.; Alvarez-Muniz, J.; Ambrosio, M.; Anchordoqui, L.
2009-06-01
These are presentations to be presented at the 31st International Cosmic Ray Conference, in Lodz, Poland during July 2009. It consists of the following presentations: (1) Correlation of the highest energy cosmic rays with nearby extragalactic objects in Pierre Auger Observatory data; (2) Discriminating potential astrophysical sources of the highest energy cosmic rays with the Pierre Auger Observatory; (3) Intrinsic anisotropy of the UHECR from the Pierre Auger Observatory; (4) Ultra-high energy photon studies with the Pierre Auger Observatory; (5) Limits on the flux of diffuse ultra high energy neutrinos set using the Pierre Auger Observatory; (6) Search for sidereal modulation of the arrival directions of events recorded at the Pierre Auger Observatory; (7) Cosmic Ray Solar Modulation Studies in the Pierre Auger Observatory; (8) Investigation of the Displacement Angle of the Highest Energy Cosmic Rays Caused by the Galactic Magnetic Field; (9) Search for coincidences with astrophysical transients in Pierre Auger Observatory data; and (10) An alternative method for determining the energy of hybrid events at the Pierre Auger Observatory.
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Le traitement de l’idéologie dans la sociologie de Luc Boltanski
Directory of Open Access Journals (Sweden)
David Vrydaghs
2006-10-01
Full Text Available IntroductionLe concept d’idéologie apparaît dans la sociologie de Luc Boltanski à partir du Nouvel Esprit du capitalisme, publié en 1999. L’auteur y revient dans La Condition fœtale, paru en 2004. On aurait donc pu se contenter de ces ouvrages pour examiner le traitement réservé à l’idéologie dans la sociologie de Luc Boltanski. On préférera pourtant revenir aux travaux antérieurs du sociologue, et ce pour deux raisons.D’abord parce que le concept d’idéologie tel qu’il est employé dans Le Nou...
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The Magnetic Observatory Buildings at the Royal Observatory, Cape
Glass, I. S.
2015-10-01
During the 1830s there arose a strong international movement, promoted by Carl Friedrich Gauss and Alexander von Humboldt, to characterise the earth's magnetic field. By 1839 the Royal Society in London, driven by Edward Sabine, had organised a "Magnetic Crusade" - the establishment of a series of magnetic and meteorological observatories around the British Empire, including New Zealand, Australia, St Helena and the Cape. This article outlines the history of the latter installation, its buildings and what became of them.
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Suurnimed jäid müümata / Maria-Kristiina Soomre
Soomre, Maria-Kristiina, 1978-
2001-01-01
9. mai Christie' oksjonist, müümata jäänud Picasso, Degas', Cezanne'i tööd. 8. mai Sotheby oksjonist, kus edukalt müüdi töid S. J. Seegeri kogust, 3,85 miljoni dollari eest M. Beckmanni "Perseuse viimane katsumus". Sotheby kaasaegse kunsti oksjonil New Yorgis müüdi 5,6 miljoni dollari eest J. Koonsi skulptuur M. Jacksonist. Müümata jäid A. Warholi "Viis supipurki", A. Calderi 3 skulptuuri
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DEFF Research Database (Denmark)
Johansen, P; Andersen, J D; Børsting, Claus
2013-01-01
on the peak height and the signal to noise data exported from the TYPER 4.0 software. With the forensic analysis parameters, all inconsistencies were eliminated in reactions with ≥10ng DNA. However, the average call rate decreased to 69.9%. The iPLEX(®) Sample ID Plus Panel was tested on 10 degraded samples......Sequenom launched the first commercial SNP typing kit for human identification, named the iPLEX(®) Sample ID Plus Panel. The kit amplifies 47 of the 52 SNPs in the SNPforID panel, amelogenin and two Y-chromosome SNPs in one multiplex PCR. The SNPs were analyzed by single base extension (SBE......) and Matrix Assisted Laser Desorption/Ionization-Time of Flight Mass Spectrometry (MALDI-TOF MS). In this study, we evaluated the accuracy and sensitivity of the iPLEX(®) Sample ID Plus Panel by comparing the typing results of the iPLEX(®) Sample ID Plus Panel with those obtained with our ISO 17025 accredited...
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ACE Gene I/D Polymorphism and Obesity in 1,574 Patients with Type 2 Diabetes Mellitus.
Pan, Yan-Hong; Wang, Min; Huang, Yan-Mei; Wang, Ying-Hui; Chen, Yin-Ling; Geng, Li-Jun; Zhang, Xiao-Xi; Zhao, Hai-Lu
2016-01-01
Association between ACE gene I/D polymorphism and the risk of overweight/obesity remains controversial. We investigated the possible relationship between ACE gene I/D polymorphism and obesity in Chinese type 2 diabetes mellitus (T2DM) patients. In this study, obesity was defined as a body mass index (BMI) value ≥ 25 kg/m 2 and subjects were classified into 4 groups (lean, normal, overweight, and obese). PCR (polymerase chain reaction) was used to detect the ACE gene I/D polymorphism in T2DM patients. Metabolic measurements including blood glucose, lipid profile, and blood pressure were obtained. Frequencies of the ACE genotypes (DD, ID, and II) were not significant among the 4 groups of BMI-defined patients ( P = 0.679) while ACE II carriers showed higher systolic blood pressure (SBP) and pulse pressure (PP) (all P ACE gene I/D polymorphism with obesity is insignificant in Chinese patients with T2DM. SBP and PP might be higher in the ACE II carriers than in the DD and ID carriers.
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International Nuclear Information System (INIS)
Mulmule, Manoj D.; Shimmy, Shankar M.; Bambole, Vaishali; Jamdar, Sahayog N.; Rawat, K.P.; Sarma, K.S.S.
2017-01-01
Idli, a steam-cooked breakfast food item consumed in India, is famous as a staple food for its spongy texture and unique fermented taste. Idli preparation is a time consuming process; although instant Idli pre-mixes as powder or batter are available in the market, they do not have the distinctive taste and aroma similar to the Idli prepared at home. Hence ready-to-eat (RTE) form of this food is in demand. Therefore, an attempt was made to prepare RTE Idli bearing similar taste as home-cooked Idli with an extended shelf-life of up to two months at an ambient temperature using Electron Beam Irradiation (EBI) at dosages 2.5 kGy, 5 kGy and 7.5 kGy and combination processing comprised of EBI dosage at 2.5 kGy and thermal treatment (80 °C for 20 min). The treated Idli's were microbiologically and sensorially evaluated at storage periods of zero day, 14 days, 30 days and 60 days. Idli's irradiated at 7.5 kGy and subjected to combination processing at 2.5 kGy and thermal treatment were shelf-stable for 60 days. 2.5 kGy and 5 kGy radiation dosages alone were not sufficient to preserve Idli samples for more than 14 days. Undesirable change in sensory properties of Idli was observed at an EBI dosage of 7.5 kGy. Sensory properties of combination processed Idli's were found to undergo minor change over the storage period. The present work suggests that lowest radiation dosage in combination with thermal treatment could be useful to achieve the extended shelf-life without considerably impairing the organoleptic quality of Ready-to-Eat Idli. - Highlights: • Idli (traditional Indian fermented food) was prepared in ready-to-eat (RTE) form. • Ready-to-eat Idli was then subjected to combination processing comprised of lowest irradiation dosage of 2.5 kGy with mild heat treatment to extend its shelf life. • Increase in hardness and decrease in brightness of combination processed Idli was observed. • Combination processed Idli was microbiologically safe and
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Radioecological Observatories - Breeding Grounds for Innovative Research
Energy Technology Data Exchange (ETDEWEB)
Steiner, Martin; Urso, Laura; Wichterey, Karin; Willrodt, Christine [Bundesamt fuer Strahlenschutz - BfS, Willy-Brandt-Strasse 5, 38226 Salzgitter (Germany); Beresford, Nicholas A.; Howard, Brenda [NERC Centre for Ecology and Hydrology - CEH, Lancaster Environment Centre, Library Av., Bailrigg, Lancaster, LA1 4AP (United Kingdom); Bradshaw, Clare; Stark, Karolina [Stockholms Universitet - SU, Universitetsvaegen 10, SE-10691 Stockholm (Sweden); Dowdall, Mark; Liland, Astrid [Norwegian Radiation Protection Authority - NRPA, P.O. Box 55, NO-1332 Oesteraas (Norway); Eyrolle- Boyer, Frederique; Guillevic, Jerome; Hinton, Thomas [Institut de Radioprotection et de Surete Nucleaire - IRSN, 31, Avenue de la Division Leclerc, 92260 Fontenay-aux-Roses (France); Gashchak, Sergey [Chornobyl Center for Nuclear Safety, Radioactive Waste and Radioecology - Chornobyl Center, 77th Gvardiiska Dyviiya str.7/1, 07100 Slavutych (Ukraine); Hutri, Kaisa-Leena; Ikaeheimonen, Tarja; Muikku, Maarit; Outola, Iisa [Radiation and Nuclear Safety Authority - STUK, P.O. Box 14, 00881 Helsinki (Finland); Michalik, Boguslaw [Glowny Instytut Gornictwa - GIG, Plac Gwarkow 1, 40-166 Katowice (Poland); Mora, Juan Carlos; Real, Almudena; Robles, Beatriz [Centro de Investigaciones Energeticas, Medioambientales y Tecnologicas - CIEMAT, Avenida complutense, 40, 28040 Madrid (Spain); Oughton, Deborah; Salbu, Brit [Norwegian University of Life Sciences - NMBU, P.O. Box 5003, NO-1432 Aas (Norway); Sweeck, Lieve [Studiecentrum voor Kernenergie/Centre d' Etude de l' Energie Nucleaire (SCK.CEN), Avenue Herrmann- Debroux 40, BE-1160 Brussels (Belgium); Yoschenko, Vasyl [National University of Life and Environmental Sciences of Ukraine (NUBiP of Ukraine), Herojiv Obrony st., 15, Kyiv-03041 (Ukraine)
2014-07-01
Within the EC-funded (FP7) Network of Excellence STAR (Strategy for Allied Radioecology, www.star-radioecology.org) the concept of Radioecological Observatories is currently being implemented on a European level for the first time. Radioecological Observatories are radioactively (and chemically) contaminated field sites that will provide a focus for joint long-term radioecological research. The benefit of this innovative approach is to create synergistic research collaborations by sharing expertise, ideas, data and resources. Research at the Radioecological Observatories will primarily focus on radioecological challenges outlined in the Strategic Research Agenda (SRA). Mechanisms to use these sites will be established under the EC-funded project COMET (Coordination and Implementation of a Pan-European Instrument for Radioecology, www.comet-radioecology.org). The European Radioecological Observatory sites were selected using a structured, progressive approach that was transparent, consistent and objective. A first screening of potential candidate sites was conducted based on the following exclusion criteria: long-term perspective for shared field work and suitability for addressing the radioecological challenges of the SRA. The proposed sites included former uranium mining and milling sites in France and Germany, the Chernobyl Exclusion Zone (CEZ) in Ukraine/Belarus and the Upper Silesian Coal Basin (USCB) in Poland. All candidate sites were prioritized based on evaluation criteria which comprised scientific issues, available infrastructure, administrative/legal constraints and financial considerations. Multi-criteria decision analysis, group discussions and recommendations provided by external experts were combined to obtain a preference order among the suggested sites. Using this approach, the Upper Silesian Coal Basin (USCB) in Poland and the Chernobyl Exclusion Zone (CEZ) were selected as Radioecological Observatories. The two sites have similar multi
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SPASE and the Heliophysics Virtual Observatories
Directory of Open Access Journals (Sweden)
J R Thieman
2010-02-01
Full Text Available The Space Physics Archive Search and Extract (SPASE project has developed an information model for interoperable access and retrieval of data within the Heliophysics (also known as space and solar physics science community. The diversity of science data archives within this community has led to the establishment of many virtual observatories to coordinate the data pathways within Heliophysics subdisciplines, such as magnetospheres, waves, radiation belts, etc. The SPASE information model provides a semantic layer and common language for data descriptions so that searches might be made across the whole of the heliophysics data environment, especially through the virtual observatories.
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Electricity and gas market observatory. 1. Quarter 2007
International Nuclear Information System (INIS)
2007-01-01
Since July 1, 2004, all electricity and gas consumers can be eligible according to their consumption site, as long as all or part of the electricity or gas consumed is designed for non-residential use. The purpose of the observatory is to provide the general public with indicators for monitoring market deregulation. It both covers the wholesale and retail electricity and gas markets in Metropolitan France. This observatory is updated every three months and data are available on CRE web site (www.cre.fr). It completes the information already published by CRE: - practical information for eligible customers: consumer guide, list of suppliers, - communications regarding markets running; CRE's annual activity report. Content: A - The electricity market: The retail electricity market (Introduction, Eligible customer segments and their respective weights, Status at April 1, 2007, Dynamic analysis: 1. Quarter 2007); The wholesale electricity market (Introduction, Traded volumes on the French wholesale electricity market and comparison with European markets, Prices on the French wholesale electricity market and European comparison, Import and export volumes, Concentration of the French electricity market, Striking facts of the 1. 2007 quarter); B - The gas market: The retail gas market (Introduction, The eligible customer segments and their respective weights, Status at April 1, 2007); The wholesale gas market (Gas pricing and gas markets in Europe, The wholesale market in France); C - Appendices: Electricity and gas market observatories combined glossary, Specific electricity market observatory glossary, Specific gas market observatory glossary
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Electricity and gas market observatory. 4. Quarter 2006
International Nuclear Information System (INIS)
2006-01-01
Since July 1, 2004, all electricity and gas consumers can be eligible according to their consumption site, as long as all or part of the electricity or gas consumed is designed for non-residential use. The purpose of the observatory is to provide the general public with indicators for monitoring market deregulation. It both covers the wholesale and retail electricity and gas markets in Metropolitan France. This observatory is updated every three months and data are available on CRE web site (www.cre.fr). It completes the information already published by CRE: - practical information for eligible customers: consumer guide, list of suppliers, - communications regarding markets running; CRE's annual activity report. Content: A - The electricity market: The retail electricity market (Introduction, Eligible customer segments and their respective weights, Status at January 1, 2007, Dynamic analysis: 4. Quarter 2006); The wholesale electricity market (Introduction, Traded volumes on the French wholesale electricity market and comparison with European markets, Prices on the French wholesale electricity market and European comparison, Import and export volumes, Concentration of the French electricity market, Striking facts of the 4. 2006 quarter); B - The gas market: The retail gas market (Introduction, The eligible customer segments and their respective weights, Status at January 1, 2007); The wholesale gas market (Gas pricing and gas markets in Europe, The wholesale market in France); C - Appendices: Electricity and gas market observatories combined glossary, Specific electricity market observatory glossary, Specific gas market observatory glossary
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Directory of Open Access Journals (Sweden)
Retha Arjadi
Full Text Available Depression screening and examination in Indonesia are highly challenging due to the disproportionately low number of mental health professionals in comparison to the Indonesian population. Self-report questionnaires on depression are cost-effective and time-efficient. The current study investigates the psychometric properties of the Indonesian Inventory of Depressive Symptomatology Self Report (IDS-SR.The participants were 904 Indonesians (aged 16-61; 50.2% female, recruited via an online survey using Qualtrics. Confirmatory factor analysis of the one-factor, three-factor, and four-factor model were explored. Convergent and divergent validity of the total score of the Indonesian IDS-SR and each factor were examined, as well as the Cronbach's Alpha reliability. In addition, an optimal cut-off score for the Indonesian IDS-SR was established using ROC curve analysis.The three-factor model of "cognitive/mood", "anxiety/arousal", and "sleep disturbance" was the best fit with the Indonesian IDS-SR data. Convergent and divergent validity were good. Cronbach's Alpha reliability was excellent for the total score, good for the factors "cognitive/mood" and "anxiety/arousal", but insufficient for the factor "sleep disturbance". The optimal cut-off score of the Indonesian IDS-SR was 14, with 87% sensitivity and 86% specificity.As a multifactorial instrument to measure depression that has good validity and reliability, the Indonesian IDS-SR can be used to assess depressive symptoms for the purpose of research and clinical practice. The optimal cut-off score of the Indonesian IDS-SR is in accordance with the internationally used cut-off score.
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International Nuclear Information System (INIS)
Meng, Qingzhen; Jia, Zhuqing; Wang, Weiping; Li, Binhong; Ma, Kangtao; Zhou, Chunyan
2011-01-01
Highlights: → Id1 was upregulated during the cardiac differentiation process of P19CL6 cells. → Id1 upregulated expression of cardiac specific genes Gata4, α-MHC and ISL1. → Id1 promoted proliferation of P19CL6 cells. → Overexpression of Id1 increased activity of TOP flash. → Wnt3a or LiCl treatment promoted Id1 expression in P19CL6 cells. -- Abstract: The inhibitor of DNA binding (Id) family of genes encodes negative regulators of basic helix-loop-helix transcription factors and has been implicated in such diverse cellular processes as differentiation, proliferation, apoptosis and migration. Id knockout mouse embryos display multiple cardiac defects but the specific role of Id1 in cardiac differentiation is unclear. In the present study, we investigated the function of Id1 in DMSO-induced P19CL6 cells, a widely-accepted cell model of cardiac differentiation. We found that Id1 was upregulated during the cardiac differentiation of P19CL6 cells. The expression of cardiac specific marker genes, Gata4, α-MHC and ISL1, was upregulated in P19CL6 cells stably transfected with Id1 (P19CL6-Id1) during cardiac differentiation. The overexpression of Id1 reduced the number of cells in G1 phase and increased the cell population in G2, M and S phases, while knockdown of Id1 increased the number of cells in G1 phase from 48.6 ± 2.51% to 62.2 ± 1.52% at day 0 of cardiac induction, and from 52.5 ± 3.41% to 63.7 ± 1.02% at day 3 after cardiac induction, indicating that Id1 promoted proliferation of P19CL6 cells. Luciferase assays showed that the activity of TOP flash was higher in P19CL6-Id1 cells than wildtype P19CL6 cells, while Id1 expression was also upregulated in P19CL6 cells treated with Wnt3a or LiCl. This indicates that there may be positive feedback between Id1 and Wnt signaling which plays an important role in cardiac differentiation.
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Geomagnetic Observatory Data for Real-Time Applications
Love, J. J.; Finn, C. A.; Rigler, E. J.; Kelbert, A.; Bedrosian, P.
2015-12-01
The global network of magnetic observatories represents a unique collective asset for the scientific community. Historically, magnetic observatories have supported global magnetic-field mapping projects and fundamental research of the Earth's interior and surrounding space environment. More recently, real-time data streams from magnetic observatories have become an important contributor to multi-sensor, operational monitoring of evolving space weather conditions, especially during magnetic storms. In this context, the U.S. Geological Survey (1) provides real-time observatory data to allied space weather monitoring projects, including those of NOAA, the U.S. Air Force, NASA, several international agencies, and private industry, (2) collaborates with Schlumberger to provide real-time geomagnetic data needed for directional drilling for oil and gas in Alaska, (3) develops products for real-time evaluation of hazards for the electric-power grid industry that are associated with the storm-time induction of geoelectric fields in the Earth's conducting lithosphere. In order to implement strategic priorities established by the USGS Natural Hazards Mission Area and the National Science and Technology Council, and with a focus on developing new real-time products, the USGS is (1) leveraging data management protocols already developed by the USGS Earthquake Program, (2) developing algorithms for mapping geomagnetic activity, a collaboration with NASA and NOAA, (3) supporting magnetotelluric surveys and developing Earth conductivity models, a collaboration with Oregon State University and the NSF's EarthScope Program, (4) studying the use of geomagnetic activity maps and Earth conductivity models for real-time estimation of geoelectric fields, (5) initiating geoelectric monitoring at several observatories, (6) validating real-time estimation algorithms against historical geomagnetic and geoelectric data. The success of these long-term projects is subject to funding constraints
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Astronomical virtual observatory and the place and role of Bulgarian one
Petrov, Georgi; Dechev, Momchil; Slavcheva-Mihova, Luba; Duchlev, Peter; Mihov, Bojko; Kochev, Valentin; Bachev, Rumen
2009-07-01
Virtual observatory could be defined as a collection of integrated astronomical data archives and software tools that utilize computer networks to create an environment in which research can be conducted. Several countries have initiated national virtual observatory programs that combine existing databases from ground-based and orbiting observatories, scientific facility especially equipped to detect and record naturally occurring scientific phenomena. As a result, data from all the world's major observatories will be available to all users and to the public. This is significant not only because of the immense volume of astronomical data but also because the data on stars and galaxies has been compiled from observations in a variety of wavelengths-optical, radio, infrared, gamma ray, X-ray and more. In a virtual observatory environment, all of this data is integrated so that it can be synthesized and used in a given study. During the autumn of the 2001 (26.09.2001) six organizations from Europe put the establishment of the Astronomical Virtual Observatory (AVO)-ESO, ESA, Astrogrid, CDS, CNRS, Jodrell Bank (Dolensky et al., 2003). Its aims have been outlined as follows: - To provide comparative analysis of large sets of multiwavelength data; - To reuse data collected by a single source; - To provide uniform access to data; - To make data available to less-advantaged communities; - To be an educational tool. The Virtual observatory includes: - Tools that make it easy to locate and retrieve data from catalogues, archives, and databases worldwide; - Tools for data analysis, simulation, and visualization; - Tools to compare observations with results obtained from models, simulations and theory; - Interoperability: services that can be used regardless of the clients computing platform, operating system and software capabilities; - Access to data in near real-time, archived data and historical data; - Additional information - documentation, user-guides, reports
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International observatory on mental health systems: structure and operation
Directory of Open Access Journals (Sweden)
Minas Harry
2009-04-01
Full Text Available Abstract Introduction Sustained cooperative action is required to improve the mental health of populations, particularly in low and middle-income countries where meagre mental health investment and insufficient human and other resources result in poorly performing mental health systems. The Observatory The International Observatory on Mental Health Systems is a mental health systems research, education and development network that will contribute to the development of high quality mental health systems in low and middle-income countries. The work of the Observatory will be done by mental health systems research, education and development groups that are located in and managed by collaborating organisations. These groups will be supported by the IOMHS Secretariat, the International IOMHS Steering Group and a Technical Reference Group. Summary The International Observatory on Mental Health Systems is: 1 the mental health systems research, education and development groups; 2 the IOMHS Steering Group; 3 the IOMHS Technical Reference Group; and 4 the IOMHS Secretariat. The work of the Observatory will depend on free and open collaboration, sharing of knowledge and skills, and governance arrangements that are inclusive and that put the needs and interests of people with mental illness and their families at the centre of decision-making. We welcome contact from individuals and institutions that wish to contribute to achieving the goals of the Observatory. Now is the time to make it happen where it matters, by turning scientific knowledge into effective action for people's health. (J.W. Lee, in his acceptance speech on his appointment as the Director-General of the World Health Organization 1.
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Invited Review Article: The Chandra X-ray Observatory
Schwartz, Daniel A.
2014-06-01
The Chandra X-ray Observatory is an orbiting x-ray telescope facility. It is one of the National Aeronautics and Space Administration's four "Great Observatories" that collectively have carried out astronomical observations covering the infrared through gamma-ray portion of the electromagnetic spectrum. Chandra is used by astronomers world-wide to acquire imaging and spectroscopic data over a nominal 0.1-10 keV (124-1.24 Å) range. We describe the three major parts of the observatory: the telescope, the spacecraft systems, and the science instruments. This article will emphasize features of the design and development driven by some of the experimental considerations unique to x-ray astronomy. We will update the on-orbit performance and present examples of the scientific highlights.
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Relationship between major depressive disorder and ACE gene I/D polymorphism in a Turkish population
Directory of Open Access Journals (Sweden)
Sema Inanir
2016-04-01
Full Text Available Abstract Background Major depressive disorder (MDD is a complex disease and a significant health problem that is prevalent across the world. Angiotensin-converting enzyme (ACE has an important role in renin-angiotensin system (RAS and converts inactive angiotensin I to a potent vasopressor and aldosterone-stimulating peptide angiotensin II. Levels of ACE in plasma vary according to the insertion/deletion (I/D polymorphism of ACE gene. Objective The aim of the current study was to examine the influence ACE gene I/D variations on the risk of MDD. Methods In the present case-control study, we analyzed ACE I/D polymorphism in 346 MDD patients and 210 healthy subjects using polymerase chain reaction technique. Results Comparing the two groups, no significant difference was observed with regard to either genotype distributions or allele frequencies of the I/D polymorphism of ACE gene. Discussion Our findings suggest that the ACE I/D polymorphism is not associated with MDD in Turkish case-control study. Further studies are still needed.
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Enhancing privacy of users in eID schemes
Shrishak, Kris; Erkin, Z.; Schaar, Remco
2016-01-01
In todays world transactions are increasingly being performed over the internetbut require identication of users as in face-to-face transactions. In order to facilitate eGovernance as well as other eCommerce services Electronic Identiation(eID) schemes, which intend to provide unique and reliable
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The Marseille Observatory 1860-1920: missed opportunities and elebrated achievements
Caplan, James
2001-10-01
After summarizing the early history of the Marseille Observatory (founded by the Jesuits and operational in 1702), I describe the circumstances leading to the takeover by Le Verrier in the 1860s. The observatory was rebuilt on the Plateau Longchamp and new instruments were installed, most notably the 80-cm Foucault glass-mirror telescope. The work of the new observatory is then presented, and the instruments described, starting with the Le Verrier period and continuing through the long directorship of Stephan, and then Bourget. The overall success of the observatory in its Longchamp site was due in part to the assiduous pursuit of routine observations and to the discovery of comets and asteroids, combined with the `exploratory' observations of `nebulae' by Stephan. In addition, the first stellar interferometry observations, and the first applications of the Fabry-Perot interferometer to nebular observations, were important achievements. On the other hand, the failure in the beginning of the twentieth century to adapt the telescopes to photography condemned the observatory to a long period of missed opportunities, from which it did not recover for several decades.
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Astronomy Against Terrorism: an Educational Astronomical Observatory Project in Peru
Ishitsuka, M.; Montes, H.; Kuroda, T.; Morimoto, M.; Ishitsuka, J.
2003-05-01
The Cosmos Coronagraphic Observatory was completely destroyed by terrorists in 1988. In 1995, in coordination with the Minister of Education of Peru, a project to construct a new Educational Astronomical Observatory has been executed. The main purpose of the observatory is to promote an interest in basic space sciences in young students from school to university levels, through basic astronomical studies and observations. The planned observatory will be able to lodge 25 visitors; furthermore an auditorium, a library and a computer room will be constructed to improve the interest of people in astronomy. Two 15-cm refractor telescopes, equipped with a CCD camera and a photometer, will be available for observations. Also a 6-m dome will house a 60-cm class reflector telescope, which will be donated soon, thanks to a fund collected and organized by the Nishi-Harima Astronomical Observatory in Japan. In addition a new modern planetarium donated by the Government of Japan will be installed in Lima, the capital of Peru. These installations will be widely open to serve the requirements of people interested in science.
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Current Status of Carl Sagan Observatory in Mexico
Sanchez-Ibarra, A.
The current status of Observatory "Carl Sagan" (OCS) of University of Sonora is presented. This project was born in 1996 focused to build a small solar-stellar observatory completely operated by remote control. The observatory will be at "Cerro Azul", a 2480 m peak in one of the best regions in the world for astronomical observation, at the Sonora-Arizona desert. The OCS, with three 16 cm solar telescopes and a 55 cm stellar telescope is one of the cheapest observatories, valuated in US200,000 Added to its scientific goals to study solar coronal holes and Supernovae Type 1A, the OCS has a strong educative and cultural program in Astronomy to all levels. At the end of 2001, we started the Program "Constelacion", to build small planetariums through all the countries with a cost of only US80,000. Also, the webcast system for transmission of the solar observations from the prototype OCS at the campus, was expanded to webcast educational programs in Astronomy since July of this year, including courses and diplomats for Latin American people. All of these advances are exposed here.
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Interactive 3D visualization for theoretical virtual observatories
Dykes, T.; Hassan, A.; Gheller, C.; Croton, D.; Krokos, M.
2018-06-01
Virtual observatories (VOs) are online hubs of scientific knowledge. They encompass a collection of platforms dedicated to the storage and dissemination of astronomical data, from simple data archives to e-research platforms offering advanced tools for data exploration and analysis. Whilst the more mature platforms within VOs primarily serve the observational community, there are also services fulfilling a similar role for theoretical data. Scientific visualization can be an effective tool for analysis and exploration of data sets made accessible through web platforms for theoretical data, which often contain spatial dimensions and properties inherently suitable for visualization via e.g. mock imaging in 2D or volume rendering in 3D. We analyse the current state of 3D visualization for big theoretical astronomical data sets through scientific web portals and virtual observatory services. We discuss some of the challenges for interactive 3D visualization and how it can augment the workflow of users in a virtual observatory context. Finally we showcase a lightweight client-server visualization tool for particle-based data sets, allowing quantitative visualization via data filtering, highlighting two example use cases within the Theoretical Astrophysical Observatory.
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Interactive 3D Visualization for Theoretical Virtual Observatories
Dykes, Tim; Hassan, A.; Gheller, C.; Croton, D.; Krokos, M.
2018-04-01
Virtual Observatories (VOs) are online hubs of scientific knowledge. They encompass a collection of platforms dedicated to the storage and dissemination of astronomical data, from simple data archives to e-research platforms offering advanced tools for data exploration and analysis. Whilst the more mature platforms within VOs primarily serve the observational community, there are also services fulfilling a similar role for theoretical data. Scientific visualization can be an effective tool for analysis and exploration of datasets made accessible through web platforms for theoretical data, which often contain spatial dimensions and properties inherently suitable for visualization via e.g. mock imaging in 2d or volume rendering in 3d. We analyze the current state of 3d visualization for big theoretical astronomical datasets through scientific web portals and virtual observatory services. We discuss some of the challenges for interactive 3d visualization and how it can augment the workflow of users in a virtual observatory context. Finally we showcase a lightweight client-server visualization tool for particle-based datasets allowing quantitative visualization via data filtering, highlighting two example use cases within the Theoretical Astrophysical Observatory.
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A robotic observatory in the city
Ruch, Gerald T.; Johnston, Martin E.
2012-05-01
The University of St. Thomas (UST) Observatory is an educational facility integrated into UST's undergraduate curriculum as well as the curriculum of several local schools. Three characteristics combine to make the observatory unique. First, the telescope is tied directly to the support structure of a four-story parking ramp instead of an isolated pier. Second, the facility can be operated remotely over an Internet connection and is capable of performing observations without a human operator. Third, the facility is located on campus in the heart of a metropolitan area where light pollution is severe. Our tests indicate that, despite the lack of an isolated pier, vibrations from the ramp do not degrade the image quality at the telescope. The remote capability facilitates long and frequent observing sessions and allows others to use the facility without traveling to UST. Even with the high background due to city lights, the sensitivity and photometric accuracy of the system are sufficient to fulfill our pedagogical goals and to perform a variety of scientific investigations. In this paper, we outline our educational mission, provide a detailed description of the observatory, and discuss its performance characteristics.
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LAGO: The Latin American giant observatory
Sidelnik, Iván; Asorey, Hernán; LAGO Collaboration
2017-12-01
The Latin American Giant Observatory (LAGO) is an extended cosmic ray observatory composed of a network of water-Cherenkov detectors (WCD) spanning over different sites located at significantly different altitudes (from sea level up to more than 5000 m a.s.l.) and latitudes across Latin America, covering a wide range of geomagnetic rigidity cut-offs and atmospheric absorption/reaction levels. The LAGO WCD is simple and robust, and incorporates several integrated devices to allow time synchronization, autonomous operation, on board data analysis, as well as remote control and automated data transfer. This detection network is designed to make detailed measurements of the temporal evolution of the radiation flux coming from outer space at ground level. LAGO is mainly oriented to perform basic research in three areas: high energy phenomena, space weather and atmospheric radiation at ground level. It is an observatory designed, built and operated by the LAGO Collaboration, a non-centralized collaborative union of more than 30 institutions from ten countries. In this paper we describe the scientific and academic goals of the LAGO project - illustrating its present status with some recent results - and outline its future perspectives.
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Observatory Sponsoring Astronomical Image Contest
2005-05-01
Forget the headphones you saw in the Warner Brothers thriller Contact, as well as the guttural throbs emanating from loudspeakers at the Very Large Array in that 1997 movie. In real life, radio telescopes aren't used for "listening" to anything - just like visible-light telescopes, they are used primarily to make images of astronomical objects. Now, the National Radio Astronomy Observatory (NRAO) wants to encourage astronomers to use radio-telescope data to make truly compelling images, and is offering cash prizes to winners of a new image contest. Radio Galaxy Fornax A Radio Galaxy Fornax A Radio-optical composite image of giant elliptical galaxy NGC 1316, showing the galaxy (center), a smaller companion galaxy being cannibalized by NGC 1316, and the resulting "lobes" (orange) of radio emission caused by jets of particles spewed from the core of the giant galaxy Click on image for more detail and images CREDIT: Fomalont et al., NRAO/AUI/NSF "Astronomy is a very visual science, and our radio telescopes are capable of producing excellent images. We're sponsoring this contest to encourage astronomers to make the extra effort to turn good images into truly spectacular ones," said NRAO Director Fred K.Y. Lo. The contest, offering a grand prize of $1,000, was announced at the American Astronomical Society's meeting in Minneapolis, Minnesota. The image contest is part of a broader NRAO effort to make radio astronomical data and images easily accessible and widely available to scientists, students, teachers, the general public, news media and science-education professionals. That effort includes an expanded image gallery on the observatory's Web site. "We're not only adding new radio-astronomy images to our online gallery, but we're also improving the organization and accessibility of the images," said Mark Adams, head of education and public outreach (EPO) at NRAO. "Our long-term goal is to make the NRAO Image Gallery an international resource for radio astronomy imagery
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The South African astronomical observatory
International Nuclear Information System (INIS)
Feast, M.
1985-01-01
A few examples of the activities of the South African Astronomical Observatory are discussed. This includes the studying of stellar evolution, dust around stars, the determination of distances to galaxies and collaboration with space experiments
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José Ricardo Riambau Jahnke
2013-01-01
Esta dissertação de mestrado vem ao encontro de nossas inquietações sobre como se dá o fe-nômeno da adesão às marcas em detrimento de outras valorações sociais tradicionalmente aceitas e fundeadas nas habilidades pessoais de interação com seus iguais do que por ditames artificialmente construídos. Entendemos que para alcançarmos este objetivo há de se partir de uma historicidade de como uma marca ser faz existir, para tanto escolhemos a Rede de Fast Food McDonalds em virtude da mesma estar po...
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Operation of the Pierre Auger Observatory
International Nuclear Information System (INIS)
Rodriguez Martino, Julio
2011-01-01
While the work to make data acquisition fully automatic continues, both the Fluorescence Detectors and the Surface Detectors of the Pierre Auger Observatory need some kind of attention from the local staff. In the first case, the telescopes are operated and monitored during the moonless periods. The ground array only needs monitoring, but the larger number of stations implies more variables to consider. AugerAccess (a high speed internet connection) will give the possibility of operating and monitoring the observatory from any place in the world. This arises questions about secure access, better control software and alarms. Solutions are already being tested and improved.
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Public relations for a national observatory
Finley, David G.
The National Radio Astronomy Observatory (NRAO) is a government-funded organization providing state-of-the art observational facilities to the astronomical community on a peer-reviewed basis. In this role, the NRAO must address three principal constituencies with its public-relations efforts. These are: the astronomical community; the funding and legislative bodies of the Federal Government; and the general public. To serve each of these constituencies, the Observatory has developed a set of public-relations initiatives supported by public-relations and outreach professionals as well as by management and scientific staff members. The techniques applied and the results achieved in each of these areas are described.
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Optimizing fixed observational assets in a coastal observatory
Frolov, Sergey; Baptista, António; Wilkin, Michael
2008-11-01
Proliferation of coastal observatories necessitates an objective approach to managing of observational assets. In this article, we used our experience in the coastal observatory for the Columbia River estuary and plume to identify and address common problems in managing of fixed observational assets, such as salinity, temperature, and water level sensors attached to pilings and moorings. Specifically, we addressed the following problems: assessing the quality of an existing array, adding stations to an existing array, removing stations from an existing array, validating an array design, and targeting of an array toward data assimilation or monitoring. Our analysis was based on a combination of methods from oceanographic and statistical literature, mainly on the statistical machinery of the best linear unbiased estimator. The key information required for our analysis was the covariance structure for a field of interest, which was computed from the output of assimilated and non-assimilated models of the Columbia River estuary and plume. The network optimization experiments in the Columbia River estuary and plume proved to be successful, largely withstanding the scrutiny of sensitivity and validation studies, and hence providing valuable insight into optimization and operation of the existing observational network. Our success in the Columbia River estuary and plume suggest that algorithms for optimal placement of sensors are reaching maturity and are likely to play a significant role in the design of emerging ocean observatories, such as the United State's ocean observation initiative (OOI) and integrated ocean observing system (IOOS) observatories, and smaller regional observatories.
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Mulmule, Manoj D.; Shimmy, Shankar M.; Bambole, Vaishali; Jamdar, Sahayog N.; Rawat, K. P.; Sarma, K. S. S.
2017-02-01
Idli, a steam-cooked breakfast food item consumed in India, is famous as a staple food for its spongy texture and unique fermented taste. Idli preparation is a time consuming process; although instant Idli pre-mixes as powder or batter are available in the market, they do not have the distinctive taste and aroma similar to the Idli prepared at home. Hence ready-to-eat (RTE) form of this food is in demand. Therefore, an attempt was made to prepare RTE Idli bearing similar taste as home-cooked Idli with an extended shelf-life of up to two months at an ambient temperature using Electron Beam Irradiation (EBI) at dosages 2.5 kGy, 5 kGy and 7.5 kGy and combination processing comprised of EBI dosage at 2.5 kGy and thermal treatment (80 °C for 20 min). The treated Idli's were microbiologically and sensorially evaluated at storage periods of zero day, 14 days, 30 days and 60 days. Idli's irradiated at 7.5 kGy and subjected to combination processing at 2.5 kGy and thermal treatment were shelf-stable for 60 days. 2.5 kGy and 5 kGy radiation dosages alone were not sufficient to preserve Idli samples for more than 14 days. Undesirable change in sensory properties of Idli was observed at an EBI dosage of 7.5 kGy. Sensory properties of combination processed Idli's were found to undergo minor change over the storage period. The present work suggests that lowest radiation dosage in combination with thermal treatment could be useful to achieve the extended shelf-life without considerably impairing the organoleptic quality of Ready-to-Eat Idli.
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Ko, Jupil; Rosen, Adam B; Brown, Cathleen N
2017-09-12
To cross-culturally adapt the Identification Functional Ankle Instability for use with Korean-speaking participants. The English version of the IdFAI was cross-culturally adapted into Korean based on the guidelines. The psychometric properties in the Korean version of the IdFAI were measured for test-retest reliability, internal consistency, criterion-related validity, discriminative validity, and measurement error 181 native Korean-speakers. Intra-class correlation coefficients (ICC 2,1 ) between the English and Korean versions of the IdFAI for test-retest reliability was 0.98 (standard error of measurement = 1.41). The Cronbach's alpha coefficient was 0.89 for the Korean versions of IdFAI. The Korean versions of the IdFAI had a strong correlation with the SF-36 (r s = -0.69, p 10 was the optimal cutoff score to distinguish between the group memberships. The minimally detectable change of the Korean versions of the IdFAI score was 3.91. The Korean versions of the IdFAI have shown to be an excellent, reliable, and valid instrument. The Korean versions of the IdFAI can be utilized to assess the presence of Chronic Ankle Instability by researchers and clinicians working among Korean-speaking populations. Implications for rehabilitation The high recurrence rate of sprains may result into Chronic Ankle Instability (CAI). The Identification of Functional Ankle Instability Tool (IdFAI) has been validated and recommended to identify patients with Chronic Ankle Instability (CAI). The Korean version of the Identification of Functional Ankle Instability Tool (IdFAI) may be also recommend to researchers and clinicians for assessing the presence of Chronic Ankle Instability (CAI) in Korean-speaking population.
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Directory of Open Access Journals (Sweden)
Carlos Castillo-Salgado
2015-11-01
Full Text Available Abstract Health observatories may differ according to their mission, institutional setting, topical emphasis or geographic coverage. This paper discusses the development of a new urban-focused health observatory, and its operational research and training infrastructure under the academic umbrella of the Department of Epidemiology and the Institute of Urban Health at the Johns Hopkins Bloomberg School of Public Health (BSPH in Baltimore, USA. Recognizing the higher education mission of the BSPH, the development of a new professional training in public health was an important first step for the development of this observatory. This new academia-based observatory is an innovative public health research and training platform offering faculty, investigators, professional epidemiology students and research partners a physical and methodological infrastructure for their operational research and training activities with both a local urban focus and a global reach. The concept of a public health observatory and its role in addressing social health inequalities in local urban settings is discussed.
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Castillo-Salgado, Carlos
2015-11-01
Health observatories may differ according to their mission, institutional setting, topical emphasis or geographic coverage. This paper discusses the development of a new urban-focused health observatory, and its operational research and training infrastructure under the academic umbrella of the Department of Epidemiology and the Institute of Urban Health at the Johns Hopkins Bloomberg School of Public Health (BSPH) in Baltimore, USA. Recognizing the higher education mission of the BSPH, the development of a new professional training in public health was an important first step for the development of this observatory. This new academia-based observatory is an innovative public health research and training platform offering faculty, investigators, professional epidemiology students and research partners a physical and methodological infrastructure for their operational research and training activities with both a local urban focus and a global reach. The concept of a public health observatory and its role in addressing social health inequalities in local urban settings is discussed.
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Exploring the Digital Universe with Europe's Astrophysical Virtual Observatory
2001-12-01
Vast Databanks at the Astronomers' Fingertips Summary A new European initiative called the Astrophysical Virtual Observatory (AVO) is being launched to provide astronomers with a breathtaking potential for new discoveries. It will enable them to seamlessly combine the data from both ground- and space-based telescopes which are making observations of the Universe across the whole range of wavelengths - from high-energy gamma rays through the ultraviolet and visible to the infrared and radio. The aim of the Astrophysical Virtual Observatory (AVO) project, which started on 15 November 2001, is to allow astronomers instant access to the vast databanks now being built up by the world's observatories and which are forming what is, in effect, a "digital sky" . Using the AVO, astronomers will, for example, be able to retrieve the elusive traces of the passage of an asteroid as it passes near the Earth and so enable them to predict its future path and perhaps warn of a possible impact. When a giant star comes to the end of its life in a cataclysmic explosion called a supernova, they will be able to access the digital sky and pinpoint the star shortly before it exploded so adding invaluable data to the study of the evolution of stars. Background information on the Astrophysical Virtual Observatory is available in the Appendix. PR Photo 34a/01 : The Astrophysical Virtual Observatory - an artist's impression. The rapidly accumulating database ESO PR Photo 34a/01 ESO PR Photo 34a/01 [Preview - JPEG: 400 x 345 pix - 90k] [Normal - JPEG: 800 x 689 pix - 656k] [Hi-Res - JPEG: 3000 x 2582 pix - 4.3M] ESO PR Photo 34a/01 shows an artist's impression of the Astrophysical Virtual Observatory . Modern observatories observe the sky continuously and data accumulates remorselessly in the digital archives. The growth rate is impressive and many hundreds of terabytes of data - corresponding to many thousands of billions of pixels - are already available to scientists. The real sky is being
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Electricity and gas market Observatory - 1. Quarter of 2012
International Nuclear Information System (INIS)
2012-03-01
The purpose of the Observatory is to provide the general public with indicators for monitoring market deregulation. It both covers the wholesale and retail electricity and gas markets in Metropolitan France. This Observatory is updated every three months and data are available on CRE web site (www.cre.fr)
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Electricity and gas market Observatory - 4. Quarter of 2011
International Nuclear Information System (INIS)
2011-12-01
The purpose of the Observatory is to provide the general public with indicators for monitoring market deregulation. It both covers the wholesale and retail electricity and gas markets in Metropolitan France. This Observatory is updated every three months and data are available on CRE web site (www.cre.fr)
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Electricity and gas market Observatory - 3. Quarter of 2011
International Nuclear Information System (INIS)
2011-09-01
The purpose of the Observatory is to provide the general public with indicators for monitoring market deregulation. It both covers the wholesale and retail electricity and gas markets in Metropolitan France. This Observatory is updated every three months and data are available on CRE web site (www.cre.fr)
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Electricity and gas market Observatory - 2. Quarter of 2011
International Nuclear Information System (INIS)
2011-06-01
The purpose of the Observatory is to provide the general public with indicators for monitoring market deregulation. It both covers the wholesale and retail electricity and gas markets in Metropolitan France. This Observatory is updated every three months and data are available on CRE web site (www.cre.fr)
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Electricity and gas market Observatory - 4. Quarter of 2010
International Nuclear Information System (INIS)
2010-12-01
The purpose of the Observatory is to provide the general public with indicators for monitoring market deregulation. It both covers the wholesale and retail electricity and gas markets in Metropolitan France. This Observatory is updated every three months and data are available on CRE web site (www.cre.fr)
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Electricity and gas market Observatory - 3. Quarter of 2012
International Nuclear Information System (INIS)
2012-09-01
The purpose of the Observatory is to provide the general public with indicators for monitoring market deregulation. It both covers the wholesale and retail electricity and gas markets in Metropolitan France. This Observatory is updated every three months and data are available on CRE web site (www.cre.fr)
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Electricity and gas market Observatory - 2. Quarter of 2012
International Nuclear Information System (INIS)
2012-06-01
The purpose of the Observatory is to provide the general public with indicators for monitoring market deregulation. It both covers the wholesale and retail electricity and gas markets in Metropolitan France. This Observatory is updated every three months and data are available on CRE web site (www.cre.fr)
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Electricity and gas market Observatory - 4. Quarter of 2012
International Nuclear Information System (INIS)
2012-12-01
The purpose of the Observatory is to provide the general public with indicators for monitoring market deregulation. It both covers the wholesale and retail electricity and gas markets in Metropolitan France. This Observatory is updated every three months and data are available on CRE web site (www.cre.fr)
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Electricity and gas market Observatory - 1. Quarter of 2011
International Nuclear Information System (INIS)
2011-03-01
The purpose of the Observatory is to provide the general public with indicators for monitoring market deregulation. It both covers the wholesale and retail electricity and gas markets in Metropolitan France. This Observatory is updated every three months and data are available on CRE web site (www.cre.fr)
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Screening of Lactobacillus plantarum isolated from fermented idli ...
African Journals Online (AJOL)
Probiotics are defined as live microorganisms which when administered in adequate amounts confer a health benefit on the host. The objective of this study was to screen eight potential probiotic Lactobacillus plantarum strains from fermented idli batter using in vitro assays such as bile tolerance, acid tolerance, transit ...
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Knoto-ID: a tool to study the entanglement of open protein chains using the concept of knotoids.
Dorier, Julien; Goundaroulis, Dimos; Benedetti, Fabrizio; Stasiak, Andrzej
2018-05-02
The backbone of most proteins forms an open curve. To study their entanglement, a common strategy consists in searching for the presence of knots in their backbones using topological invariants. However, this approach requires to close the curve into a loop, which alters the geometry of curve. Knoto-ID allows evaluating the entanglement of open curves without the need to close them, using the recent concept of knotoids which is a generalization of the classical knot theory to open curves. Knoto-ID can analyse the global topology of the full chain as well as the local topology by exhaustively studying all subchains or only determining the knotted core. Knoto-ID permits to localize topologically non-trivial protein folds that are not detected by informatics tools detecting knotted protein folds. Knoto-ID is written in C ++ and includes R (www.R-project.org) scripts to generate plots of projections maps, fingerprint matrices and disk matrices. Knoto-ID is distributed under the GNU General Public License (GPL), version 2 or any later version and is available at https://github.com/sib-swiss/Knoto-ID. A binary distribution for Mac OS X, Linux and Windows with detailed user guide and examples can be obtained from https://www.vital-it.ch/software/Knoto-ID. julien.dorier@sib.swiss.
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Spectrum of supernova 1972e in NGC 5253
International Nuclear Information System (INIS)
Branch, D.; Tull, R.G.
1979-01-01
Photoelectric scans of the spectrum of SN 1972e are presented. The observations were obtained at the McDonald Observatory between 15 and 50 days after maximum light with a spectral resolution ranging from 4 to 20 Angstroms. Line identifications (Ca II, Fe II, Si II, and possibly He I) are discussed briefly. It is suggested that the emission feature identified by Kirshner and Oke as Hα may have been produced by Fe II
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Spectroscopic classification of AT 2017byx as a Type Ia Supernova
Vinko, J.; Wheeler, J. C.; Sarneczky, K.; Szakats, R.; Szalai, T.; Szekely, P.; HETDEX Collaboration
2017-05-01
During the commissioning phase of the Hobby-Eberly Telescope Dark Energy Experiment (HETDEX) survey we observed AT 2017byx (ATLAS17bla, PS17bve) at R.A.=14:17:48.36 Dec.=+52:41:54.6 with the Visible Integral-field Replicable Unit Spectrograph (VIRUS) at McDonald Observatory on 2017-04-28.2 UT. The spectrum (range between 3500 and 5500 Angstroms) indicates that AT 2017byx is a Type Ia supernova.
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VizieR Online Data Catalog: The MASSIVE survey. VI. Warm ionized gas. (Pandya+, 2017)
Pandya, V.; Greene, J. E.; Ma, C.-P.; Veale, M.; Ene, I.; Davis, T. A.; Blakeslee, J. P.; Goulding, A. D.; McConnell, N. J.; Nyland, K.; Thomas, J.
2017-10-01
This paper is based on integral-field spectra obtained with the Mitchell Spectrograph (formerly VIRUS-P) on the 2.7m Harlan J. Smith Telescope at McDonald Observatory. The spectra cover the wavelength range from ~3500Å to ~5800Å. We generally have three dithered pointings for a total of 738 spectra per galaxy. See the MASSIVE survey description in Paper I: Ma+, 2014, J/ApJ/795/158 (1 data file).
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150th Anniversary of the Astronomical Observatory Library of Sciences
Solntseva, T.
The scientific library of the Astronomical observatory of Kyiv Taras Shevchenko University is one of the oldest ones of such a type in Ukraine. Our Astronomical Observatory and its scientific library will celebrate 150th anniversary of their foundation. 900 volumes of duplicates of Olbers' private library underlay our library. These ones were acquired by Russian Academy of Sciences for Poulkovo observatory in 1841 but according to Struve's order were transmitted to Kyiv Saint Volodymyr University. These books are of great value. There are works edited during Copernicus', Kepler's, Galilei's, Newton's, Descartes' lifetime. Our library contains more than 100000 units of storage - monographs, periodical astronomical editions from the first (Astronomische Nachrichten, Astronomical journal, Monthly Notices etc.), editions of the majority of the astronomical observatories and institutions of the world, unique astronomical atlases and maps
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Exploring the Digital Universe with Europe's Astrophysical Virtual Observatory
2001-12-01
N° 73-2001 - Paris, 5 December 2001 The aim of AVO is to give astronomers instant access to the vast databanks now being built up by the world's observatories and forming what is in effect a "digital sky". Using AVO astronomers will be able, for example, to retrieve the elusive traces of the passage of an asteroid as it passes the Earth and so predict its future path and perhaps warn of a possible impact. When a giant star comes to the end of its life in a cataclysmic explosion called a supernova, they will be able to access the digital sky and pinpoint the star shortly before it exploded, adding invaluable data to the study of the evolution of stars. Modern observatories observe the sky continuously and data accumulates remorselessly in the digital archives. The growth rate is impressive and many hundreds of terabytes of data -corresponding to many thousands of billions of pixels - are already available to scientists. The real sky is being digitally reconstructed in the databanks. The volume and complexity of data and information available to astronomers are overwhelming. Hence the problem of how astronomers can possibly manage, distribute and analyse this great wealth of data. The Astrophysical Virtual Observatory will enable them to meet the challenge and "put the Universe online". AVO is a three-year project, funded by the European Commission under its Research and Technological Development (RTD) scheme, to design and implement a virtual observatory for the European astronomical community. The Commission has awarded a contract valued at EUR 4m for the project, starting on 15 November. AVO will provide software tools to enable astronomers to access the multi-wavelength data archives over the Internet and so give them the capability to resolve fundamental questions about the Universe by probing the digital sky. Equivalent searches of the "real" sky would, in comparison, both be prohibitively costly and take far too long. Towards a Global Virtual Observatory The
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A non-parametric peak calling algorithm for DamID-Seq.
Directory of Open Access Journals (Sweden)
Renhua Li
Full Text Available Protein-DNA interactions play a significant role in gene regulation and expression. In order to identify transcription factor binding sites (TFBS of double sex (DSX-an important transcription factor in sex determination, we applied the DNA adenine methylation identification (DamID technology to the fat body tissue of Drosophila, followed by deep sequencing (DamID-Seq. One feature of DamID-Seq data is that induced adenine methylation signals are not assured to be symmetrically distributed at TFBS, which renders the existing peak calling algorithms for ChIP-Seq, including SPP and MACS, inappropriate for DamID-Seq data. This challenged us to develop a new algorithm for peak calling. A challenge in peaking calling based on sequence data is estimating the averaged behavior of background signals. We applied a bootstrap resampling method to short sequence reads in the control (Dam only. After data quality check and mapping reads to a reference genome, the peaking calling procedure compromises the following steps: 1 reads resampling; 2 reads scaling (normalization and computing signal-to-noise fold changes; 3 filtering; 4 Calling peaks based on a statistically significant threshold. This is a non-parametric method for peak calling (NPPC. We also used irreproducible discovery rate (IDR analysis, as well as ChIP-Seq data to compare the peaks called by the NPPC. We identified approximately 6,000 peaks for DSX, which point to 1,225 genes related to the fat body tissue difference between female and male Drosophila. Statistical evidence from IDR analysis indicated that these peaks are reproducible across biological replicates. In addition, these peaks are comparable to those identified by use of ChIP-Seq on S2 cells, in terms of peak number, location, and peaks width.
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A non-parametric peak calling algorithm for DamID-Seq.
Li, Renhua; Hempel, Leonie U; Jiang, Tingbo
2015-01-01
Protein-DNA interactions play a significant role in gene regulation and expression. In order to identify transcription factor binding sites (TFBS) of double sex (DSX)-an important transcription factor in sex determination, we applied the DNA adenine methylation identification (DamID) technology to the fat body tissue of Drosophila, followed by deep sequencing (DamID-Seq). One feature of DamID-Seq data is that induced adenine methylation signals are not assured to be symmetrically distributed at TFBS, which renders the existing peak calling algorithms for ChIP-Seq, including SPP and MACS, inappropriate for DamID-Seq data. This challenged us to develop a new algorithm for peak calling. A challenge in peaking calling based on sequence data is estimating the averaged behavior of background signals. We applied a bootstrap resampling method to short sequence reads in the control (Dam only). After data quality check and mapping reads to a reference genome, the peaking calling procedure compromises the following steps: 1) reads resampling; 2) reads scaling (normalization) and computing signal-to-noise fold changes; 3) filtering; 4) Calling peaks based on a statistically significant threshold. This is a non-parametric method for peak calling (NPPC). We also used irreproducible discovery rate (IDR) analysis, as well as ChIP-Seq data to compare the peaks called by the NPPC. We identified approximately 6,000 peaks for DSX, which point to 1,225 genes related to the fat body tissue difference between female and male Drosophila. Statistical evidence from IDR analysis indicated that these peaks are reproducible across biological replicates. In addition, these peaks are comparable to those identified by use of ChIP-Seq on S2 cells, in terms of peak number, location, and peaks width.
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RNA-ID, a Powerful Tool for Identifying and Characterizing Regulatory Sequences.
Brule, C E; Dean, K M; Grayhack, E J
2016-01-01
The identification and analysis of sequences that regulate gene expression is critical because regulated gene expression underlies biology. RNA-ID is an efficient and sensitive method to discover and investigate regulatory sequences in the yeast Saccharomyces cerevisiae, using fluorescence-based assays to detect green fluorescent protein (GFP) relative to a red fluorescent protein (RFP) control in individual cells. Putative regulatory sequences can be inserted either in-frame or upstream of a superfolder GFP fusion protein whose expression, like that of RFP, is driven by the bidirectional GAL1,10 promoter. In this chapter, we describe the methodology to identify and study cis-regulatory sequences in the RNA-ID system, explaining features and variations of the RNA-ID reporter, as well as some applications of this system. We describe in detail the methods to analyze a single regulatory sequence, from construction of a single GFP variant to assay of variants by flow cytometry, as well as modifications required to screen libraries of different strains simultaneously. We also describe subsequent analyses of regulatory sequences. © 2016 Elsevier Inc. All rights reserved.
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Fraudulent ID using face morphs: Experiments on human and automatic recognition.
Robertson, David J; Kramer, Robin S S; Burton, A Mike
2017-01-01
Matching unfamiliar faces is known to be difficult, and this can give an opportunity to those engaged in identity fraud. Here we examine a relatively new form of fraud, the use of photo-ID containing a graphical morph between two faces. Such a document may look sufficiently like two people to serve as ID for both. We present two experiments with human viewers, and a third with a smartphone face recognition system. In Experiment 1, viewers were asked to match pairs of faces, without being warned that one of the pair could be a morph. They very commonly accepted a morphed face as a match. However, in Experiment 2, following very short training on morph detection, their acceptance rate fell considerably. Nevertheless, there remained large individual differences in people's ability to detect a morph. In Experiment 3 we show that a smartphone makes errors at a similar rate to 'trained' human viewers-i.e. accepting a small number of morphs as genuine ID. We discuss these results in reference to the use of face photos for security.
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Creation of an instrument maintenance program at W. M. Keck Observatory
Hill, G. M.; Kwok, S. H.; Mader, J. A.; Wirth, G. D.; Dahm, S. E.; Goodrich, R. W.
2014-08-01
Until a few years ago, the W. M. Keck Observatory (WMKO) did not have a systematic program of instrument maintenance at a level appropriate for a world-leading observatory. We describe the creation of such a program within the context of WMKO's lean operations model which posed challenges but also guided the design of the system and resulted in some unique and notable capabilities. These capabilities and the flexibility of the system have led to its adoption across the Observatory for virtually all PM's. The success of the Observatory in implementing the program and its impact on instrument reliability are presented. Lessons learned are reviewed and strategic implications discussed.
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Building a roll-off roof or dome observatory a complete guide for design and construction
Hicks, John Stephen
2016-01-01
Almost every practical astronomer eventually aspires to have a fixed, permanent observatory for his or her telescope. A roll-off roof or dome observatory is the answer for the most popular home observatory design. Almost every practical astronomer eventually aspires to have a fixed, permanent observatory for his or her telescope. A roll-off roof or dome observatory is the answer for the most popular home observatory design. Building a Roll-Off or Dome Observatory will help you decide whether to embark on the venture and will certainly increase your enthusiasm for the project. The author, both an amateur astronomer and a professional landscape architect, answers many of the common questions asked about observatory construction, covering the following topics: • Zoning, and by-law requirements common to most states, towns and municipalities • Where to locate the observatory • How to tailor the observatory for your particular needs • Tools and structural components required • Possible variations in de...
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Astronomical databases of Nikolaev Observatory
Protsyuk, Y.; Mazhaev, A.
2008-07-01
Several astronomical databases were created at Nikolaev Observatory during the last years. The databases are built by using MySQL search engine and PHP scripts. They are available on NAO web-site http://www.mao.nikolaev.ua.
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Improving geomagnetic observatory data in the South Atlantic Anomaly
Matzka, Jürgen; Morschhauser, Achim; Brando Soares, Gabriel; Pinheiro, Katia
2016-04-01
The Swarm mission clearly proofs the benefit of coordinated geomagnetic measurements from a well-tailored constellation in order to recover as good as possible the contributions of the various geomagnetic field sources. A similar truth applies to geomagnetic observatories. Their scientific value can be maximised by properly arranging the position of individual observatories with respect to the geometry of the external current systems in the ionosphere and magnetosphere, with respect to regions of particular interest for secular variation, and with respect to regions of anomalous electric conductivity in the ground. Here, we report on our plans and recent efforts to upgrade geomagnetic observatories and to recover unpublished data from geomagnetic observatories at low latitudes in the South Atlantic Anomaly. In particular, we target the magnetic equator with the equatorial electrojet and low latitudes to characterise the Sq- and ring current. The observatory network that we present allows also to study the longitudinal structure of these external current systems. The South Atlantic Anomaly region is very interesting due to its secular variation. We will show newly recovered data and comparisons with existing data sets. On the technical side, we introduce low-power data loggers. In addition, we use mobile phone data transfer, which is rapidly evolving in the region and allows timely data access and quality control at remote sites that previously were not connected to the internet.
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Virtual hydrology observatory: an immersive visualization of hydrology modeling
Su, Simon; Cruz-Neira, Carolina; Habib, Emad; Gerndt, Andreas
2009-02-01
The Virtual Hydrology Observatory will provide students with the ability to observe the integrated hydrology simulation with an instructional interface by using a desktop based or immersive virtual reality setup. It is the goal of the virtual hydrology observatory application to facilitate the introduction of field experience and observational skills into hydrology courses through innovative virtual techniques that mimic activities during actual field visits. The simulation part of the application is developed from the integrated atmospheric forecast model: Weather Research and Forecasting (WRF), and the hydrology model: Gridded Surface/Subsurface Hydrologic Analysis (GSSHA). Both the output from WRF and GSSHA models are then used to generate the final visualization components of the Virtual Hydrology Observatory. The various visualization data processing techniques provided by VTK are 2D Delaunay triangulation and data optimization. Once all the visualization components are generated, they are integrated into the simulation data using VRFlowVis and VR Juggler software toolkit. VR Juggler is used primarily to provide the Virtual Hydrology Observatory application with fully immersive and real time 3D interaction experience; while VRFlowVis provides the integration framework for the hydrologic simulation data, graphical objects and user interaction. A six-sided CAVETM like system is used to run the Virtual Hydrology Observatory to provide the students with a fully immersive experience.
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NASA X-Ray Observatory Completes Tests Under Harsh Simulated Space Conditions
1998-07-01
NASA's most powerful X-ray observatory has successfully completed a month-long series of tests in the extreme heat, cold, and airless conditions it will encounter in space during its five-year mission to shed new light on some of the darkest mysteries of the universe. The Advanced X-ray Astrophysics Facility was put through the rigorous testing as it was alternately heated and cooled in a special vacuum chamber at TRW Space and Electronics Group in Redondo Beach, Calif., NASA's prime contractor for the observatory. "Successful completion of thermal vacuum testing marks a significant step in readying the observatory for launch aboard the Space Shuttle in January," said Fred Wojtalik, manager of the Observatory Projects Office at NASA's Marshall Space Flight Center in Huntsville, Ala. "The observatory is a complex, highly sophisticated, precision instrument," explained Wojtalik. "We are pleased with the outcome of the testing, and are very proud of the tremendous team of NASA and contractor technicians, engineers and scientists that came together and worked hard to meet this challenging task." Testing began in May after the observatory was raised into the 60-foot thermal vacuum chamber at TRW. Testing was completed on June 20. During the tests the Advanced X-ray Astrophysics Facility was exposed to 232 degree heat and 195 degree below zero Fahrenheit cold. During four temperature cycles, all elements of the observatory - the spacecraft, telescope, and science instruments - were checked out. Computer commands directing the observatory to perform certain functions were sent from test consoles at TRW to all Advanced X-ray Astrophysics Facility components. A team of contractor and NASA engineers and scientists monitored and evaluated the results. Commands were also sent from, and test data monitored at, the Advanced X-ray Astrophysics Facility Operations Control Center in Cambridge, Mass., as part of the test series. The observatory will be managed and controlled from
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The brazilian indigenous planetary-observatory
Afonso, G. B.
2003-08-01
We have performed observations of the sky alongside with the Indians of all Brazilian regions that made it possible localize many indigenous constellations. Some of these constellations are the same as the other South American Indians and Australian aborigines constellations. The scientific community does not have much of this information, which may be lost in one or two generations. In this work, we present a planetary-observatory that we have made in the Park of Science Newton Freire-Maia of Paraná State, in order to popularize the astronomical knowledge of the Brazilian Indians. The planetary consists, essentially, of a sphere of six meters in diameter and a projection cylinder of indigenous constellations. In this planetary we can identify a lot of constellations that we have gotten from the Brazilian Indians; for instance, the four seasonal constellations: the Tapir (spring), the Old Man (summer), the Deer (autumn) and the Rhea (winter). A two-meter height wooden staff that is posted vertically on the horizontal ground similar to a Gnomon and stones aligned with the cardinal points and the soltices directions constitutes the observatory. A stone circle of ten meters in diameter surrounds the staff and the aligned stones. During the day we observe the Sun apparent motions and at night the indigenous constellations. Due to the great community interest in our work, we are designing an itinerant indigenous planetary-observatory to be used in other cities mainly by indigenous and primary schools teachers.
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Brazil to Join the European Southern Observatory
2010-12-01
The Federative Republic of Brazil has yesterday signed the formal accession agreement paving the way for it to become a Member State of the European Southern Observatory (ESO). Following government ratification Brazil will become the fifteenth Member State and the first from outside Europe. On 29 December 2010, at a ceremony in Brasilia, the Brazilian Minister of Science and Technology, Sergio Machado Rezende and the ESO Director General, Tim de Zeeuw signed the formal accession agreement aiming to make Brazil a Member State of the European Southern Observatory. Brazil will become the fifteen Member State and the first from outside Europe. Since the agreement means accession to an international convention, the agreement must now be submitted to the Brazilian Parliament for ratification [1]. The signing of the agreement followed the unanimous approval by the ESO Council during an extraordinary meeting on 21 December 2010. "Joining ESO will give new impetus to the development of science, technology and innovation in Brazil as part of the considerable efforts our government is making to keep the country advancing in these strategic areas," says Rezende. The European Southern Observatory has a long history of successful involvement with South America, ever since Chile was selected as the best site for its observatories in 1963. Until now, however, no non-European country has joined ESO as a Member State. "The membership of Brazil will give the vibrant Brazilian astronomical community full access to the most productive observatory in the world and open up opportunities for Brazilian high-tech industry to contribute to the European Extremely Large Telescope project. It will also bring new resources and skills to the organisation at the right time for them to make a major contribution to this exciting project," adds ESO Director General, Tim de Zeeuw. The European Extremely Large Telescope (E-ELT) telescope design phase was recently completed and a major review was
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Application of Sharī‘ah contracts in contemporary Islamic finance: A maqāṣid perspective
Directory of Open Access Journals (Sweden)
Younes Soualhi
2015-12-01
Full Text Available This research exposes the underlying maqāṣid embedded in Sharī‘ah contracts as applied in Islamic banking and finance. It addresses the problem of not observing maqāṣid in nominated and combined Sharī‘ah contracts as well as the problem of not sufficiently imbuing maqāṣid in products developed by Islamic financial institutions. As a benchmark of the maqāṣid of wealth, the research adopts Ibn ‘Āshūr’s classification of maqāṣid to evaluate the conformity of Sharī‘ah contracts to Maqāṣid al-Sharī‘ah namely, justice, circulation, transparency, and firmness. The study focuses on three markets related to the application of Sharī‘ah contracts, namely, banking, Islamic capital market, and takāful. The study concludes that, by and large, the application of Sharī‘ah contracts has observed Maqāṣid al-Sharī‘ah during its development and initial application stages of Islamic finance products; however, offering such products in the market has raised economic questions as to their viability and economic values. In addition, the malpractice of some Sharī‘ah contracts has long raised concerns as to the maqāṣid compliance of such products. The research recommends a de-sophistication of Islamic financial engineering to minimise the possibility of convergence with conventional finance. The research also emphasises product differentiation based on less complicated combined Sharī‘ah contracts.
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Directory of Open Access Journals (Sweden)
Laura Murianni
2008-06-01
Full Text Available
Background: The number of indicators aiming to provide a clear picture of healthcare needs and the quality and efficiency of healthcare systems and services has proliferated in recent years. The activity of the National Observatory on Health Status in the Italian Regions is multidisciplinary, involving around 280 public health care experts, clinicians, demographers, epidemiologists, mathematicians, statisticians and economists who with their different competencies, and scientific interests aim to improve the collective health of individuals and their conditions through the use of “core indicators”. The main outcome of the National Observatory on Health Status in the Italian Regions is the “Osservasalute Report – a report on health status and the quality of healthcare assistance in the Italian Regions”.
Methods: The Report adopts a comparative analysis, methodology and internationally validated indicators.
Results: The results of Observatory Report show it is necessary:
• to improve the monitoring of primary health care services (where the chronic disease could be cared through implementation of clinical path;
• to improve in certain areas of hospital care such as caesarean deliveries, as well as the average length of stay in the pre-intervention phase, etc.;
• to try to be more focused on the patients/citizens in our health care services; • to practice more geographical interventions to reduce the North-South divide as well as reduce gender inequity.
Conclusions: The health status of Italian people is good with positive results and outcomes, but in the meantime some further efforts should be done especially in the South that still has to improve the quality and the organization of health care services. There are huge differences in accuracy and therefore usefulness of the reported data, both between diseases and between
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Chicago's Dearborn Observatory: a study in survival
Bartky, Ian R.
2000-12-01
The Dearborn Observatory, located on the Old University of Chicago campus from 1863 until 1888, was America's most promising astronomical facility when it was founded. Established by the Chicago Astronomical Society and directed by one of the country's most gifted astronomers, it boasted the largest telescope in the world and virtually unlimited operating funds. The Great Chicago Fire of 1871 destroyed its funding and demolished its research programme. Only via the sale of time signals and the heroic efforts of two amateur astronomers did the Dearborn Observatory survive.
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The origin of the Hawaiian Volcano Observatory
International Nuclear Information System (INIS)
Dvorak, John
2011-01-01
I first stepped through the doorway of the Hawaiian Volcano Observatory in 1976, and I was impressed by what I saw: A dozen people working out of a stone-and-metal building perched at the edge of a high cliff with a spectacular view of a vast volcanic plain. Their primary purpose was to monitor the island's two active volcanoes, Kilauea and Mauna Loa. I joined them, working for six weeks as a volunteer and then, years later, as a staff scientist. That gave me several chances to ask how the observatory had started.
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ACE I/D polymorphism in Indian patients with hypertrophic cardiomyopathy and dilated cardiomyopathy
DEFF Research Database (Denmark)
Rai, Taranjit Singh; Dhandapany, Perundurai Subramaniam; Ahluwalia, Tarun Veer Singh
2008-01-01
The study was carried to determine the association of angiotensin converting enzyme (ACE) insertion/deletion (I/D) polymorphism with the risk of hypertrophic cardiomyopathy (HCM), dilated cardiomyopathy (DCM), and restrictive cardiomyopathy (RCM).......The study was carried to determine the association of angiotensin converting enzyme (ACE) insertion/deletion (I/D) polymorphism with the risk of hypertrophic cardiomyopathy (HCM), dilated cardiomyopathy (DCM), and restrictive cardiomyopathy (RCM)....
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The Architectural and Instrumental Heritage of the Strasbourg University Observatory
Davoigneau, Jean
When, in 1872, Alsace was handed over to Germany, Empperor Wilhelm I decided to make Strasbourg the showcase of his empire, and in particular to build a prestigious university and an observatory. The construction of the observatory was entrusted to the astronomer August Winnecke (1835-1897), former director of the Pulkovo observatory, and to the Baumeister Hermann Eggert. Begun in 1876, the work was completed in 1880. The astronomical instruments, ordered from German makers, were installed during the winter of 1880-1881, and the observatory was inaugurated on September 22, 1881 at the general assembly of the Astronomische Gesellschaft, the international association of astronomers, whose secretary was Winnecke. Marking the south-eastern extremity of the ‘imperial axis’, the architecture of the university observatory harmonizes perfectly with the new German city built on the former French parade grounds. The astronomical heritage operation conducted at the beginning of the present decade provides a richly docurnented and illustrated inventory of both the architecture and instruments of this institution. This work has also highlighted the unique quality of the collection of instruments, befitting the long and complex history of this institution.
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Deep Space Climate Observatory (DSCOVR)
National Oceanic and Atmospheric Administration, Department of Commerce — The Deep Space Climate ObserVatoRy (DSCOVR) satellite is a NOAA operated asset at the first Lagrange (L1) point. The primary space weather instrument is the PlasMag...
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ID-1 mass storage system for mainframe by using FDDI network
International Nuclear Information System (INIS)
Morita, Y.; Fujii, H.; Inoue, E.; Kodama, H. Manabe, A.; Miyamoto, A.; Nomachi, M.; Watase, Y.; Yasu, Y.
1994-01-01
The authors have developed an ID-1 mass storage system as a distributed data server for Fujitsu mainframe computers. The system consists of a SONY ID-1 recorder DIR-1000, a tape robot system DMS-24 and a SCSI-II interface DFC-1500, which are connected to Spar Station 10 with an FDDI interface. The maximum speed of 7.5 Mbytes/sec is achieved for data transfer between Sparc Station 10 memory and DIR-1000 with a buffer size of 1 Mbytes. The system has been used successfully since last October to migrate more than 1 Tbytes data
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A functionally significant polymorphism in ID3 is associated with human coronary pathology.
Directory of Open Access Journals (Sweden)
Ani Manichaikul
Full Text Available We previously identified association between the ID3 SNP rs11574 and carotid intima-media thickness in the Diabetes Heart Study, a predominantly White diabetic population. The nonsynonymous SNP rs11574 results in an amino acid substitution in the C-terminal region of ID3, attenuating the dominant negative function of ID3 as an inhibitor of basic HLH factor E12-mediated transcription. In the current investigation, we characterize the association between the functionally significant polymorphism in ID3, rs11574, with human coronary pathology.The Multi-Ethnic Study of Atherosclerosis (MESA is a longitudinal study of subclinical cardiovascular disease, including non-Hispanic White (n = 2,588, African American (n = 2,560 and Hispanic (n = 2,130 participants with data on coronary artery calcium (CAC. The Coronary Assessment in Virginia cohort (CAVA included 71 patients aged 30-80 years, undergoing a medically necessary cardiac catheterization and intravascular ultrasound (IVUS at the University of Virginia. ID3 SNP rs11574 risk allele was associated with the presence of CAC in MESA Whites (P = 0.017. In addition, the risk allele was associated with greater atheroma burden and stenosis in the CAVA cohort (P = 0.003, P = 0.04 respectively. The risk allele remained predictive of atheroma burden in multivariate analysis (Model 1: covariates age, gender, and LDL, regression coefficient = 9.578, SE = 3.657, p = 0.0110; Model 2: covariates Model 1, presence of hypertension, presence of diabetes, regression coefficient = 8.389, SE = 4.788, p = 0.0163.We present additional cohorts that demonstrate association of ID3 SNP rs11574 directly with human coronary artery pathology as measured by CAC and IVUS: one a multiethnic, relatively healthy population with low levels of diabetes and the second a predominantly White population with a higher incidence of T2DM referred for cardiac catheterization.
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Using the Critical Zone Observatory Network to Put Geology into Environmental Science
Brantley, S. L.
2017-12-01
The use of observatories to study the environment in the U.S.A. arguably began in 1910. Since then, many environmental observatories were set up to study impacts of land use change. At that time, observatories did not emphasize geological structure. Around 2004, scientists in the U.S.A. began to emphasize the need to study the Earth's surface as one integrated system that includes the geological underpinnings. In 2007, the Geosciences Directorate within the U.S. National Science Foundation established the Critical Zone Observatory (CZO) program. Today the CZO network has grown to 9 observatories, and 45 countries now host such observatories. A CZO is an observatory that promotes the study of the entire layer of Earth's surface from vegetation canopy to groundwater as one entity. The observatories are somewhat similar to other NSF-funded observatories such as Long Term Ecological Research (LTER) sites but they differ in that they emphasize the history of the landscape and how it mediates today's fluxes. LTERs largely focus on ecological science. The concepts of CZ science and CZOs - developed by the Geosciences Directorate - have been extraordinarily impactful: we now have deeper understanding of how surficial processes respond to tectonic, climatic, and anthropogenic drivers. One reason CZOs succeed is that they host scientists who make measurements in one place that cross timescales from that of the meteorologist to the geologist. The NSF Geosciences Directorate has thus promoted insights showing that many of the unexplained mysteries of "catchment science" or "ecosystem science" can be explained by the underlying geological story of a site. The scientific challenges of this endeavor are dwarfed, however, by cultural challenges. Specifically, while both CZOs and observatories such as LTERs struggle to publish many types of data from different disciplines in a continually changing cyber-world, only CZO scientists find they must repeatedly explain why such
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Evaluation of the Micro-ID system for the identification of Yersinia pestis.
Harrison, D N; Williams, J E
1985-01-01
One hundred isolates of Yersinia pestis identified by conventional means were tested by the Micro-ID system to assess its reliability for distinguishing Y. pestis from other members of the family Enterobacteriaceae. The Micro-ID system gave Y. pestis as a choice for the identification of 89 of these cultures, although not always as the first choice. Most nitrate-negative strains of Y. pestis keyed out with Yersinia pseudotuberculosis as first choice and Y. pestis as second or fourth choice.
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Abbot, R. I.; Mulholland, J. D.; Shelus, P. J.
1974-01-01
Observations of Saturn's satellites were reduced by means of secondary reference stars obtained by reduction of Palomar Sky Survey (PSS) plates. This involved the use of 39 SAO stars and plate overlap technique to determine the coordinates of 59 fainter stars in the satellite field. Fourteen plate constants were determined for each of the two PSS plates. Comparison of two plate measurement and reduction techniques on the satellite measurements demonstrate the existence of a serious background gradient effect and the utility of microdensitometry to eliminate this error source in positional determinations of close satellites.
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Continued program of planetary study at the University of Texas McDonald Observatory
International Nuclear Information System (INIS)
Smith, H.J.; Barker, E.S.; Cochran, W.D.; Trafton, L.M.
1986-01-01
The beginning of eclipses of the Pluto-Charon system was detected. The onset of coma formation of P/Halley at 5.4 au was detected and evidence of sublimation at 4.8 au when CN emission was detected. Extensive spatial maps of the gas in the comae of comets Halley and Giacobini-Zinner were obtained in fall 1985. Halley was time variable, and Giacobini-Zinner was depleted in C 2 and C 3 relative to CN. Comet Kopff was shown to have a pre-perihelion brightness maximum of its gas, consistent with mantle development if the comet is a high obliquity object. New Haser model scale lengths for CN, C 3 , and C 2 were determined using results from the Faint Comet Survey. Spectra of 12 asteroids in unusual orbits showed no evidence of any comet-like emission features. In particular, 3200 Phaethon (1983 TB) has no gas or dust coma, in spite of the similarity of its orbit with the Geminid meteor stream. Data were analyzed on Saturn's H 2 and CH 4 bands for the recent southern summer using a Tomasko-Doose type of haze distribution. This haze model fits the data moderately well, giving a CH 4 mixing ratio of (4.2 + or 0.4)x003. Simple functions were found to approximate the collision-induced rotation-translation thermal opacity of H 2
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Desprez, Pierre-Yves; Campisi, Judith
2014-08-19
A method for treatment of breast cancer and other types of cancer. The method comprises targeting and modulating Id-1 gene expression, if any, for the Id-1 gene, or gene products in breast or other epithelial cancers in a patient by delivering products that modulate Id-1 gene expression. When expressed, Id-1 gene is a prognostic indicator that cancer cells are invasive and metastatic.
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Pfitzner, Elvira
By means of a small watercolor, painted by a musicologist, the existence of the highschool observatory of Chemnitz was rediscovered. The small observatory was build in 1893 by means of funds and a donation: after WW I it was also used for popular education. During Nazi times, the observatory fell into neglect, and the mechanical damage made it impossible to put it back into operation after WW II The building was torn down in 1964 and forgotten.
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Radikal konservativ idédebat og højreautoritær fascination i Danmark, ca. 1928-1940
DEFF Research Database (Denmark)
Holm, Adam
1999-01-01
Historie, Højreradikalisme, Konservatisme, Fascisme, Mellemkrigstid, Idéhistorie, Intellektuelle......Historie, Højreradikalisme, Konservatisme, Fascisme, Mellemkrigstid, Idéhistorie, Intellektuelle...
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Recent results from the Compton Observatory
Energy Technology Data Exchange (ETDEWEB)
Michelson, P.F.; Hansen, W.W. [Stanford Univ., CA (United States)
1994-12-01
The Compton Observatory is an orbiting astronomical observatory for gamma-ray astronomy that covers the energy range from about 30 keV to 30 GeV. The Energetic Gamma Ray Experiment Telescope (EGRET), one of four instruments on-board, is capable of detecting and imaging gamma radiation from cosmic sources in the energy range from approximately 20 MeV to 30 GeV. After about one month of tests and calibration following the April 1991 launch, a 15-month all sky survey was begun. This survey is now complete and the Compton Observatory is well into Phase II of its observing program which includes guest investigator observations. Among the highlights from the all-sky survey discussed in this presentation are the following: detection of five pulsars with emission above 100 MeV; detection of more than 24 active galaxies, the most distant at redshift greater than two; detection of many high latitude, unidentified gamma-ray sources, some showing significant time variability; detection of at least two high energy gamma-ray bursts, with emission in one case extending to at least 1 GeV. EGRET has also detected gamma-ray emission from solar flares up to energies of at least 2 GeV and has observed gamma-rays from the Large Magellanic Cloud.
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Motivations underlying the existence of Latin American media observatories
Directory of Open Access Journals (Sweden)
Dra. Susana Herrera Damas
2006-01-01
Full Text Available Recently appeared, media observatories are media supervision instances that overlook media activity. Even though little has been systematized about their activity, they are realities that grow in a slow but progressive manner. The present paper objective is to justify the reason for being of Latinamerican observatories, describe the context in which they are born and show how in their essence they house a true and legitimate service vocation. The manuscript aims to explain that media observatories appear in Latinamerica because of two reasons: first, someone has to oversee those who oversee, and secondly it may no be suitable any more that fact that those who keep an eye on may also commit mistakes.
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The ubiquitin ligase ASB4 promotes trophoblast differentiation through the degradation of ID2.
Directory of Open Access Journals (Sweden)
W H Davin Townley-Tilson
Full Text Available Vascularization of the placenta is a critical developmental process that ensures fetal viability. Although the vascular health of the placenta affects both maternal and fetal well being, relatively little is known about the early stages of placental vascular development. The ubiquitin ligase Ankyrin repeat, SOCS box-containing 4 (ASB4 promotes embryonic stem cell differentiation to vascular lineages and is highly expressed early in placental development. The transcriptional regulator Inhibitor of DNA binding 2 (ID2 negatively regulates vascular differentiation during development and is a target of many ubiquitin ligases. Due to their overlapping spatiotemporal expression pattern in the placenta and contrasting effects on vascular differentiation, we investigated whether ASB4 regulates ID2 through its ligase activity in the placenta and whether this activity mediates vascular differentiation. In mouse placentas, ASB4 expression is restricted to a subset of cells that express both stem cell and endothelial markers. Placentas that lack Asb4 display immature vascular patterning and retain expression of placental progenitor markers, including ID2 expression. Using JAR placental cells, we determined that ASB4 ubiquitinates and represses ID2 expression in a proteasome-dependent fashion. Expression of ASB4 in JAR cells and primary isolated trophoblast stem cells promotes the expression of differentiation markers. In functional endothelial co-culture assays, JAR cells ectopically expressing ASB4 increased endothelial cell turnover and stabilized endothelial tube formation, both of which are hallmarks of vascular differentiation within the placenta. Co-transfection of a degradation-resistant Id2 mutant with Asb4 inhibits both differentiation and functional responses. Lastly, deletion of Asb4 in mice induces a pathology that phenocopies human pre-eclampsia, including hypertension and proteinuria in late-stage pregnant females. These results indicate that
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Electricity and gas market Observatory - 1. Quarter of 2013
International Nuclear Information System (INIS)
2013-03-01
The purpose of the Observatory is to provide the general public with indicators for monitoring market deregulation. It both covers the wholesale and retail electricity and gas markets in Metropolitan France. Since 2013, it also covers the wholesale CO 2 market. This Observatory is updated every three months and data are available on CRE web site (www.cre.fr)
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Group-ID based RFID Mutual Authentication
Directory of Open Access Journals (Sweden)
LEE, Y.
2013-11-01
Full Text Available For passive type RFID tags, EPCglobal Class 1 Generation-2 Revision is used widely as a de facto standard. As it was designed for low cost, it is quite vulnerable to security issues, such as privacy concerns. This paper presents a new RFID mutual authentication protocol, which is designed to be configured on EPC Gen2 platform and to meet various security requirements while providing efficiency using PRNG (Pseudo Random Number Generator. Group-ID is used to minimize the authentication time. Security analysis of the proposed protocol is discussed.
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Directory of Open Access Journals (Sweden)
Gutmann Anja
2010-01-01
Full Text Available Abstract Background ID proteins are dominant negative inhibitors of basic helix-loop-helix transcription factors that have multiple functions during development and cellular differentiation. Ectopic (over-expression of ID1 extends the lifespan of primary human epithelial cells. High expression levels of ID1 have been detected in multiple human malignancies, and in some have been correlated with unfavorable clinical prognosis. ID1 protein is localized at the centrosomes and forced (over-expression of ID1 results in errors during centrosome duplication. Results Here we analyzed the steady state expression levels of the four ID-proteins in 18 tumor cell lines and assessed the number of centrosome abnormalities. While expression of ID1, ID2, and ID3 was detected, we failed to detect protein expression of ID4. Expression of ID1 correlated with increased supernumerary centrosomes in most cell lines analyzed. Conclusions This is the first report that shows that not only ectopic expression in tissue culture but endogenous levels of ID1 modulate centrosome numbers. Thus, our findings support the hypothesis that ID1 interferes with centrosome homeostasis, most likely contributing to genomic instability and associated tumor aggressiveness.
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Geomagnetic secular variation at the African observatories
International Nuclear Information System (INIS)
Haile, T.
2002-10-01
Geomagnetic data from ten observatories in the African continent with time series data length of more than three decades have been analysed. All-day annual mean values of the D, H and Z components were used to study secular variations in the African region. The residuals in D, H and Z components obtained after removing polynomial fits have been examined in relation to the sunspot cycle. The occurrence of the 1969-1970 worldwide geomagnetic impulse in each observatory is studied. It is found that the secular variation in the field can be represented for most of the observatories with polynomials of second or third degree. Departures from these trends are observed over the Southern African region where strong local magnetic anomalies have been observed. The residuals in the geomagnetic field components have been shown to exhibit parallelism with the periods corresponding to double solar cycle for some of the stations. A clear latitudinal distribution in the geomagnetic component that exhibits the 1969-70 jerk is shown. The jerk appears in the plots of the first differences in H for the southern most observatories of Hermanus, Hartebeesthoek, and Tsuemb, while the Z plots show the jerk for near equatorial and equatorial stations of Antananarivo, Luanda Belas, Bangui and Addis Ababa. There is some indication for this jerk in the first difference plots of D for the northern stations of M'Bour and Tamanrasset. The plots of D rather strongly suggest the presence of a jerk around 1980 at most of the stations. (author)
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Reengineering observatory operations for the time domain
Seaman, Robert L.; Vestrand, W. T.; Hessman, Frederic V.
2014-07-01
Observatories are complex scientific and technical institutions serving diverse users and purposes. Their telescopes, instruments, software, and human resources engage in interwoven workflows over a broad range of timescales. These workflows have been tuned to be responsive to concepts of observatory operations that were applicable when various assets were commissioned, years or decades in the past. The astronomical community is entering an era of rapid change increasingly characterized by large time domain surveys, robotic telescopes and automated infrastructures, and - most significantly - of operating modes and scientific consortia that span our individual facilities, joining them into complex network entities. Observatories must adapt and numerous initiatives are in progress that focus on redesigning individual components out of the astronomical toolkit. New instrumentation is both more capable and more complex than ever, and even simple instruments may have powerful observation scripting capabilities. Remote and queue observing modes are now widespread. Data archives are becoming ubiquitous. Virtual observatory standards and protocols and astroinformatics data-mining techniques layered on these are areas of active development. Indeed, new large-aperture ground-based telescopes may be as expensive as space missions and have similarly formal project management processes and large data management requirements. This piecewise approach is not enough. Whatever challenges of funding or politics facing the national and international astronomical communities it will be more efficient - scientifically as well as in the usual figures of merit of cost, schedule, performance, and risks - to explicitly address the systems engineering of the astronomical community as a whole.
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Waring, Justin; Bishop, Simon
2013-04-01
This paper investigates transitions in the social organisation of medicine found in the extended opportunities for private corporations to own, manage and deliver public healthcare services in the English National Health Service. It follows recent calls to explain the reconstruction of medical work without reducing analysis to either the structures of organisational control or the strategic resistance of doctors. Accordingly, the paper considers how doctors interact, mediate and co-create new organisational environments. Central to our analysis are the variable sources of power that influence whether doctors acquiesce, resist or re-create change. Drawing on ethnographic research carried out between 2006 and 2010 in two Independent Sector Treatment Centres - private providers of public healthcare - the paper shows how doctors' responses to bureaucratic and commercial structures reflect their own structured forms of power, which have variable value within this new commercial environment. These include clinical experience and specialist knowledge, but also social and economic influence. Building on established sociological debates, these divergent sources of power explain how for some doctors the expansion of private healthcare might involve more extreme forms of McDonaldization, while for others it might involve opportunities for Commercial Re-stratification. Copyright © 2013 Elsevier Ltd. All rights reserved.
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Angiotensin-converting enzyme I/D polymorphism in chronic obstructive pulmonary disease
Directory of Open Access Journals (Sweden)
Pabst S
2009-12-01
Full Text Available Abstract Study objective The etiology of chronic obstructive lung disease (COPD is unclear. It is supposed to be the product of an exogenous antigenic stimulus, such as tobacco smoke, and an endogenous genetic susceptibility. The angiotensin-converting enzyme (ACE gene contains a polymorphism based on the presence (insertion [I] or absence (deletion [D] of a 287-bp nonsense domain, resulting in three different genotypes (II, ID and DD. The aim of the study was to find out whether the ACE gene polymorphism can determine the course of COPD. Patients and design We genotyped 152 Caucasian patients with COPD and 158 healthy controls for the ACE (I/D polymorphism. We divided the COPD group into one group of 64 patients with a stable course of disease, defined as less than three hospitalizations over the last three years due to COPD, and another group of 88 patients with an instable course with more than three hospitalizations. Results The I-allele was significantly associated with an increased risk for COPD in a dominant model (OR 1.67 (95% CI 1.00 to 2.78, p = 0.048, but not in a recessive or co-dominant model. Moreover, the I-allele of ACE (I/D was significantly increased in patients with a stable course of COPD (p = 0.012 compared with controls. In a dominant model (II/ID v DD we found an even stronger association between the I-allele and a stable course of COPD (OR 3.24 (95% CI 1.44 to 7.31, p = 0.003. Conclusion These data suggest that the presence of an ACE I-allele determines a stable course of COPD.
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Oberste, M S; Weaver, S C; Watts, D M; Smith, J F
1998-01-01
Venezuelan equine encephalitis (VEE) virus was isolated in 1993, 1994, and 1995 from human cases of acute, undifferentiated, febrile illness in the Peruvian Amazon Basin. Two virus isolates were recovered in 1994 from Peruvian soldiers at a jungle outpost near Pantoja in northern Peru, and 10 isolates were obtained from military personnel and civilians in 1993-1995 in Iquitos, an urban center in northeastern Peru. The genetic relationship of these isolates to other VEE virus strains was determined by sequencing 856-867 nucleotide reverse transcription-polymerase chain reaction fragments derived from the PE2 glycoprotein gene. The sequences were compared with those of other VEE virus strains, including representatives of the IAB, IC, ID, IE, II, and IIIC subtypes. The two Pantoja isolates were most closely related to subtype IC and ID viruses previously isolated in Colombia and Venezuela, and to the ID viruses isolated during the 1970s in Iquitos. All of the recent Iquitos isolates were similar to one another, but they were more closely related to Panamanian ID strains than to isolates previously obtained in Iquitos, Peru, or in Colombia and Venezuela. The recent Iquitos VEE viral isolates were the first Panama-genotype VEE ID virus strains identified outside of the Republic of Panama.
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OpenID Connect as a security service in cloud-based medical imaging systems.
Ma, Weina; Sartipi, Kamran; Sharghigoorabi, Hassan; Koff, David; Bak, Peter
2016-04-01
The evolution of cloud computing is driving the next generation of medical imaging systems. However, privacy and security concerns have been consistently regarded as the major obstacles for adoption of cloud computing by healthcare domains. OpenID Connect, combining OpenID and OAuth together, is an emerging representational state transfer-based federated identity solution. It is one of the most adopted open standards to potentially become the de facto standard for securing cloud computing and mobile applications, which is also regarded as "Kerberos of cloud." We introduce OpenID Connect as an authentication and authorization service in cloud-based diagnostic imaging (DI) systems, and propose enhancements that allow for incorporating this technology within distributed enterprise environments. The objective of this study is to offer solutions for secure sharing of medical images among diagnostic imaging repository (DI-r) and heterogeneous picture archiving and communication systems (PACS) as well as Web-based and mobile clients in the cloud ecosystem. The main objective is to use OpenID Connect open-source single sign-on and authorization service and in a user-centric manner, while deploying DI-r and PACS to private or community clouds should provide equivalent security levels to traditional computing model.
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Kumalasari, Indah
2013-01-01
The purpose of this study is to analyze and explain the effect Customer Satisfaction of the switching barrier and Customer Retention. Type of research is explanatory research with survey methods. Sampling technique using probability sampling with simple random sampling. The population in this study is a student of the Faculty of Business Administration Forces 2012-2013 UB ever make purchases at McDonald's Malang and obtained sample was 102 respondents using Machin formula. This study uses de...
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The Pierre Auger Observatory Upgrade - Preliminary Design Report
Energy Technology Data Exchange (ETDEWEB)
Aab, Alexander [Univ. Siegen (Germany); et al.
2016-04-12
The Pierre Auger Observatory has begun a major Upgrade of its already impressive capabilities, with an emphasis on improved mass composition determination using the surface detectors of the Observatory. Known as AugerPrime, the upgrade will include new 4 m2 plastic scintillator detectors on top of all 1660 water-Cherenkov detectors, updated and more flexible surface detector electronics, a large array of buried muon detectors, and an extended duty cycle for operations of the fluorescence detectors. This Preliminary Design Report was produced by the Collaboration in April 2015 as an internal document and information for funding agencies. It outlines the scientific and technical case for AugerPrime. We now release it to the public via the arXiv server. We invite you to review the large number of fundamental results already achieved by the Observatory and our plans for the future.
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The origin of the Hawaiian Volcano Observatory
Energy Technology Data Exchange (ETDEWEB)
Dvorak, John [University of Hawaii' s Institute for Astronomy (United States)
2011-05-15
I first stepped through the doorway of the Hawaiian Volcano Observatory in 1976, and I was impressed by what I saw: A dozen people working out of a stone-and-metal building perched at the edge of a high cliff with a spectacular view of a vast volcanic plain. Their primary purpose was to monitor the island's two active volcanoes, Kilauea and Mauna Loa. I joined them, working for six weeks as a volunteer and then, years later, as a staff scientist. That gave me several chances to ask how the observatory had started.
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Studies of Cosmic Ray Composition and Air Shower Structure with the Pierre Auger Observatory
Energy Technology Data Exchange (ETDEWEB)
Abraham, : J.; Abreu, P.; Aglietta, M.; Aguirre, C.; Ahn, E.J.; Allard, D.; Allekotte, I.; Allen, J.; Alvarez-Muniz, J.; Ambrosio, M.; Anchordoqui, L.
2009-06-01
These are presentations to be presented at the 31st International Cosmic Ray Conference, in Lodz, Poland during July 2009. It consists of the following presentations: (1) Measurement of the average depth of shower maximum and its fluctuations with the Pierre Auger Observatory; (2) Study of the nuclear mass composition of UHECR with the surface detectors of the Pierre Auger Observatory; (3) Comparison of data from the Pierre Auger Observatory with predictions from air shower simulations: testing models of hadronic interactions; (4) A Monte Carlo exploration of methods to determine the UHECR composition with the Pierre Auger Observatory; (5) The delay of the start-time measured with the Pierre Auger Observatory for inclined showers and a comparison of its variance with models; (6) UHE neutrino signatures in the surface detector of the Pierre Auger Observatory; and (7) The electromagnetic component of inclined air showers at the Pierre Auger Observatory.
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Averaging and sampling for magnetic-observatory hourly data
Directory of Open Access Journals (Sweden)
J. J. Love
2010-11-01
Full Text Available A time and frequency-domain analysis is made of the effects of averaging and sampling methods used for constructing magnetic-observatory hourly data values. Using 1-min data as a proxy for continuous, geomagnetic variation, we construct synthetic hourly values of two standard types: instantaneous "spot" measurements and simple 1-h "boxcar" averages. We compare these average-sample types with others: 2-h average, Gaussian, and "brick-wall" low-frequency-pass. Hourly spot measurements provide a statistically unbiased representation of the amplitude range of geomagnetic-field variation, but as a representation of continuous field variation over time, they are significantly affected by aliasing, especially at high latitudes. The 1-h, 2-h, and Gaussian average-samples are affected by a combination of amplitude distortion and aliasing. Brick-wall values are not affected by either amplitude distortion or aliasing, but constructing them is, in an operational setting, relatively more difficult than it is for other average-sample types. It is noteworthy that 1-h average-samples, the present standard for observatory hourly data, have properties similar to Gaussian average-samples that have been optimized for a minimum residual sum of amplitude distortion and aliasing. For 1-h average-samples from medium and low-latitude observatories, the average of the combination of amplitude distortion and aliasing is less than the 5.0 nT accuracy standard established by Intermagnet for modern 1-min data. For medium and low-latitude observatories, average differences between monthly means constructed from 1-min data and monthly means constructed from any of the hourly average-sample types considered here are less than the 1.0 nT resolution of standard databases. We recommend that observatories and World Data Centers continue the standard practice of reporting simple 1-h-average hourly values.
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The LCOGT Science Archive and Data Pipeline
Lister, Tim; Walker, Z.; Ciardi, D.; Gelino, C. R.; Good, J.; Laity, A.; Swain, M.
2013-01-01
Las Cumbres Observatory Global Telescope (LCOGT) is building and deploying a world-wide network of optical telescopes dedicated to time-domain astronomy. In the past year, we have deployed and commissioned four new 1m telescopes at McDonald Observatory, Texas and at CTIO, Chile, with more to come at SAAO, South Africa and Siding Spring Observatory, Australia. To handle these new data sources coming from the growing LCOGT network, and to serve them to end users, we have constructed a new data pipeline and Science Archive. We describe the new LCOGT pipeline, currently under development and testing, which makes use of the ORAC-DR automated recipe-based data reduction pipeline and illustrate some of the new data products. We also present the new Science Archive, which is being developed in partnership with the Infrared Processing and Analysis Center (IPAC) and show some of the new features the Science Archive provides.
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The STELLA Robotic Observatory on Tenerife
Directory of Open Access Journals (Sweden)
Klaus G. Strassmeier
2010-01-01
Full Text Available The Astrophysical Institute Potsdam (AIP and the Instituto de Astrofísica de Canarias (IAC inaugurated the robotic telescopes STELLA-I and STELLA-II (STELLar Activity on Tenerife on May 18, 2006. The observatory is located on the Izaña ridge at an elevation of 2400 m near the German Vacuum Tower Telescope. STELLA consists of two 1.2 m alt-az telescopes. One telescope fiber feeds a bench-mounted high-resolution echelle spectrograph while the other telescope feeds a wide-field imaging photometer. Both scopes work autonomously by means of artificial intelligence. Not only that the telescopes are automated, but the entire observatory operates like a robot, and does not require any human presence on site.
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VizieR Online Data Catalog: Abundances for all seven stars in Latham 1 (O'Connell+, 2016)
O'Connell, J. E.; Martens, K.; Frinchaboy, P. M.
2017-03-01
Observations for all target stars were obtained at McDonald Observatory with the Otto Struve 2.1m telescope instrumented with the Sandiford Cass Echelle Spectrometer (SES; R=λ/Δλ~60000) in 2013 and 2014 June. The spectrograph setup was centered near 6175Å in 2013 and 6375Å in 2014 with wavelength coverage spanning from ~5350-6560Å and ~5560-6750Å, respectively (see Table2 for observation dates and exposure times). (3 data files).
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A Search for Circumstellar Gas-Disk Variability in F-type Stars
Adkins, Ally; Montgomery, Sharon Lynn; Welsh, Barry
2018-01-01
Over the past six years, short-term (night-to-night) variability in the CaII K-line (3933Å) absorption has been detected towards 22 rapidly-rotating A-type stars, all but four of them discovered by us. Most of these stars are young (age McDonald Observatory) during June 2017. The appearance or absence of similar short-lived, Doppler-shifted absorption in F-type stars serves as a test of our understanding of the underlying phenomena.
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Spectroscopic Classification of SN 2017ghm as a Type Ia Supernova
Vinko, J.; Wheeler, J. C.; Wang, X.; Li, W.; Li, Z.; Xiang, D.; Rui, L.; Lin, H.; Xu, Z.; Li, B.; Zhao, H.; Wang, L.; Tan, H.; Zhang, J.
2017-09-01
An optical spectrum (range 360-680 nm) of SN 2017ghm (=PTSS-17uyml), discovered by the PMO-Tsinghua Supernova Survey (PTSS, http://www.cneost.org/ptss/), was obtained with the new "Low Resolution Spectrograph-2" (LRS2) on the 10m Hobby-Eberly Telescope at McDonald Observatory by S. Rostopchin on 2017 Aug 31.17 UT. The spectrum is consistent with that of a heavily reddened Type Ia supernova (with Av > 2.3 mag) around maximum light.
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GD 358 - the demise of rotational splitting?
International Nuclear Information System (INIS)
Hill, J.A.
1987-01-01
Observations of GD 358 were obtained at the McDonald Observatory in 1982 and 1985 in order to determine its periods, stability, and rates of period change. The period structure could not be resolved, and the results indicate that GD 358 does not fit the rotational splitting model. It is suggested that if the changes in the amplitude spectra of GD 358 are due to beating of stable modes, then the number of modes must be large. 7 references
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Angiotensin-I converting enzyme gene and I/D polymorphism ...
Indian Academy of Sciences (India)
Angiotensin-I converting enzyme gene and I/D polymorphism distribution in the Greek population and a comparison with other European populations. Sekerli Eleni Katsanidis Dimitrios Papadopoulou Vaya Makedou Areti Vavatsi Norma Gatzola Magdalini. Research Note Volume 87 Issue 1 April 2008 pp 91-93 ...
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Angiotensin-converting enzyme gene I/D polymorphism in Pakistani ...
African Journals Online (AJOL)
hope&shola
two were the cases of antiphospholipid syndrome. Parsa et al. (2002) conducted an association of 3 polymor- phisms in angiotensin-converting enzyme including I/D polymorphism and 2 polymorphisms were associated with systemic lupus erythematosus and Lupus Nephritis among non-Caucasians that includes Hispanic, ...
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Plans for a Northern Cascadia Subduction Zone Observatory
Heesemann, M.; Wang, K.; Davis, E.; Chadwell, C. D.; Nissen, E.; Moran, K.; Scherwath, M.
2017-12-01
To accurately assess earthquake and tsunami hazards posed by the Cascadia Subduction Zone, it is critically important to know which area of the plate interface is locked and whether or not part of the energy is being released aseismically by slow creep on the fault. Deeper locking that extends further to the coast produces stronger shaking in population centers. Shallow locking, on the other hand, leads to bigger tsunamis. We will report on and discuss plans for a new amphibious Northern Cascadia Subduction Zone Observatory (NCSZO) that will leverage the existing NEPTUNE cabled seafloor observatory, which is operated by Ocean Networks Canada (ONC), and the onshore network of geodetic stations, which is operated by Natural Resources Canada (NRCan). To create a NCSZO we plan to (1) add a network of seven GPS-Acoustic (GPS-A) sites offshore Vancouver Island, (2) establish a Deformation Front Observatory, and (3) improve the existing onshore geodetic network (see Figure below). The GPS-A stations will provide the undisturbed motion of the Juan de Fuca (JdF) Plate (1), deformation of the JdF plate (2), deformation of the overriding plate (3-7) and a cabled laboratory to study the potential for continuous GPS-A measurements (6). The Deformation Front Observatory will be used to study possible transient slip events using seafloor pressure and tilt instruments and fluid flux meters.
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Pätid võtsid varastatud ID-kaardiga kiirlaene / Põim Kama
Kama, Põim, 1985-
2008-01-01
ID-kaardi vargusega seotud pettusjuhtumist ning jaanuaris jõustunud rahapesu ja terrorismi rahastamise tõkestamise seaduse sättest, mis kohustab laenufirmasid esimese tehingu sooritamisel kliendiga silmast silma kohtuma. Lisatud: kiirlaenufirmad vilistavad seadusele
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Rodriguez Viales, Rebecca; Diotel, Nicolas; Ferg, Marco; Armant, Olivier; Eich, Julia; Alunni, Alessandro; März, Martin; Bally-Cuif, Laure; Rastegar, Sepand; Strähle, Uwe
2015-03-01
The teleost brain has the remarkable ability to generate new neurons and to repair injuries during adult life stages. Maintaining life-long neurogenesis requires careful management of neural stem cell pools. In a genome-wide expression screen for transcription regulators, the id1 gene, encoding a negative regulator of E-proteins, was found to be upregulated in response to injury. id1 expression was mapped to quiescent type I neural stem cells in the adult telencephalic stem cell niche. Gain and loss of id1 function in vivo demonstrated that Id1 promotes stem cell quiescence. The increased id1 expression observed in neural stem cells in response to injury appeared independent of inflammatory signals, suggesting multiple antagonistic pathways in the regulation of reactive neurogenesis. Together, we propose that Id1 acts to maintain the neural stem cell pool by counteracting neurogenesis-promoting signals. © 2014 AlphaMed Press.
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Chen, B; Han, B H; Sun, X H; Lim, R W
1997-01-15
We have examined the role of an Id-like protein, Id3 (also known as HLH462), in the regulation of muscle-specific gene expression. Id proteins are believed to block expression of muscle-specific genes by preventing the dimerization between ubiquitous bHLH proteins (E proteins) and myogenic bHLH proteins such as MyoD. Consistent with its putative role as an inhibitor of differentiation, Id3 mRNA was detected in proliferating skeletal muscle cells, was further induced by basic fibroblast growth factor (bFGF) and was down-regulated in differentiated muscle cultures. Overexpression of Id3 efficiently inhibited the MyoD-mediated activation of the muscle-specific creatine kinase (MCK) reporter gene. Deletion analysis indicated that the C-terminal 15 amino acids of Id3 are critical for the full inhibitory activity while deleting up to 42 residues from the C-terminus of the related protein, Id2, did not affect its ability to inhibit the MCK reporter gene. Chimeric protein containing the N-terminal region of Id3 and the C-terminus of Id2 was also non-functional in transfected cells. In contrast, wild-type Id3, the C-terminal mutants, and the Id3/Id2 chimera could all interact with the E-protein E47in vitro. Additional studies indicated that truncation of the Id3 C-terminus might have adversely affected the expression level of the mutant proteins but the Id3/Id2 chimera was stably expressed. Taken together, our results revealed a more complex requirement for the expression and proper function of the Id family proteins than was hitherto expected.
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DEFF Research Database (Denmark)
Fyhrquist, Frej; Eriksson, Anders; Saijonmaa, Outi
2013-01-01
INTRODUCTION: Short telomeres are often associated with cardiovascular risk factors and age-related diseases, while the angiotensin converting enzyme (ACE) gene insertion/deletion polymorphism (DD, ID, II) has shown such associations less consistently. We hypothesized that telomere length...... and association of telomere length with cardiovascular risk is affected by ACE (I/D) genotype. METHODS: We measured leucocyte telomere length (LTL) by Southern blot and analysed ACE I/D genotypes in 1249 subjects with hypertension and left ventricular hypertrophy (LVH). We examined interactions of ACE I...
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Liu, Hai-Ying; Kobernus, Mike; Broday, David; Bartonova, Alena
2014-12-12
In recent years there has been a trend to view the Citizens' Observatory as an increasingly essential tool that provides an approach for better observing, understanding, protecting and enhancing our environment. However, there is no consensus on how to develop such a system, nor is there any agreement on what a Citizens' Observatory is and what results it could produce. The increase in the prevalence of Citizens' Observatories globally has been mirrored by an increase in the number of variables that are monitored, the number of monitoring locations and the types of participating citizens. This calls for a more integrated approach to handle the emerging complexities involved in this field, but before this can be achieved, it is essential to establish a common foundation for Citizens' Observatories and their usage. There are many aspects to a Citizens' Observatory. One view is that its essence is a process that involves environmental monitoring, information gathering, data management and analysis, assessment and reporting systems. Hence, it requires the development of novel monitoring technologies and of advanced data management strategies to capture, analyse and survey the data, thus facilitating their exploitation for policy and society. Practically, there are many challenges in implementing the Citizens' Observatory approach, such as ensuring effective citizens' participation, dealing with data privacy, accounting for ethical and security requirements, and taking into account data standards, quality and reliability. These concerns all need to be addressed in a concerted way to provide a stable, reliable and scalable Citizens' Observatory programme. On the other hand, the Citizens' Observatory approach carries the promise of increasing the public's awareness to risks in their environment, which has a corollary economic value, and enhancing data acquisition at low or no cost. In this paper, we first propose a conceptual framework for a Citizens' Observatory
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2011-08-03
...-Challis National Forest, ID; Upper North Fork HFRA Ecosystem Restoration Project Environmental Impact... improve the health of the ecosystem and reach the desired future condition. DATES: Comments concerning the... Ecosystem Restoration Project EIS, P.O. Box 180, 11 Casey Rd., North Fork, ID 83466. Comments may also be...
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Part of an observatory of opinions on risks
International Nuclear Information System (INIS)
Brenot, J.
1999-01-01
An observatory of opinions about risks constitutes the frame in which can be developed exchanges between research workers, engineers, experts, persons in charge of authorities and societies managers for who the way whom the public takes into account the risks constitutes an element of the management, the decision or the communication. The Institute of Protection and Nuclear Safety (I.P.S.N.) has, with the passing of the years, build a such observatory whom activities are developed according to several directions. (N.C.)
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The LAGO (Large Aperture GRB Observatory) in Peru
Tueros-Cuadros, E.; Otiniano, L.; Chirinos, J.; Soncco, C.; Guevara-Day, W.
2012-07-01
The Large Aperture GRBs Observatory is a continental-wide observatory devised to detect high energy (around 100 GeV) component of Gamma Ray Bursts (GRBs), by using the single particle technique in arrays of Water Cherenkov Detectors (WCDs) at high mountain sites of Argentina, Bolivia, Colombia, Guatemala, Mexico, Venezuela and Peru. Details of the instalation and operation of the detectors in Marcapomacocha in Peru at 4550 m.a.s.l. are given. The detector calibration method will also be shown.
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Magdalena Ridge Observatory Interferometer: Status Update
National Research Council Canada - National Science Library
Creech-Eakman, M. J; Bakker, E. J; Buscher, D. F; Coleman, T. A; Haniff, C. A; Jurgenson, C. A; Klinglesmith, III, D. A; Parameswariah, C. B; Romero, V. D; Shtromberg, A. V; Young, J. S
2006-01-01
The Magdalena Ridge Observatory Interferometer (MROI) is a ten element optical and near-infrared imaging interferometer being built in the Magdalena mountains west of Socorro, NM at an altitude of 3230 m...
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Building a Roll-Off Roof Observatory A Complete Guide for Design and Construction
Hicks, John
2009-01-01
Almost every practical astronomer who takes the pursuit to its second level aspires to a fixed, permanent housing for his telescope, permitting its rapid and comfortable use and avoiding hours of setting-up time for each observing session. A roll-off roof observatory is the simplest and by far the most popular observatory design for today’s practical astronomers. Building a Roll-off Roof Observatory will help you decide whether to embark on the venture and will certainly provoke your enthusiasm for the project. The author, both an amateur astronomer and professional landscape architect, answers many of the common questions asked around observatory construction covering the following topics: Site planning, zoning, and by-law requirements common to most states, towns and municipalities Opportunities for locating the observatory Tailoring the observatory for your particular use Tools and structural components required to build it Variations in footing design to suit your soil conditions Variations possible in ...
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idSpace Tooling and Training for collaborative distributed product innovation
Rutjens, Marjo; Bitter-Rijpkema, Marlies; Grube, Pascal; Heider, Thomas
2009-01-01
Rutjens, M., Bitter-Rijpkema, M., Grube, P. P., & Heider, T. (2009). idSpace Tooling and Training for collaborative distributed product innovation. Workshop during the e-Learning Baltic conference. June, 17-19, 2009, Rostock, Germany.
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Energy Technology Data Exchange (ETDEWEB)
Liu, Chen; Jin, Rong [Department of Immunology, Peking University Health Science Center, Beijing (China); Wang, Hong-Cheng [Oklahoma Medical Research Foundation, Oklahoma City, OK (United States); Tang, Hui; Liu, Yuan-Feng; Qian, Xiao-Ping; Sun, Xiu-Yuan; Ge, Qing [Department of Immunology, Peking University Health Science Center, Beijing (China); Sun, Xiao-Hong, E-mail: sunx@omrf.org [Oklahoma Medical Research Foundation, Oklahoma City, OK (United States); Zhang, Yu, E-mail: zhangyu007@bjmu.edu.cn [Department of Immunology, Peking University Health Science Center, Beijing (China)
2013-06-21
Highlights: •Id1 expression enables naïve T cell proliferation without anti-CD28 co-stimulation. •Id1 expression facilitates T cells survival when stimulated with anti-CD3. •Elevation of IL-2 production by Id1 contributes increased proliferation and survival. •Id1 potentiates NF-κB activation by anti-CD3 stimulation. -- Abstract: Although the role of E proteins in the thymocyte development is well documented, much less is known about their function in peripheral T cells. Here we demonstrated that CD4 promoter-driven transgenic expression of Id1, a naturally occurring dominant-negative inhibitor of E proteins, can substitute for the co-stimulatory signal delivered by CD28 to facilitate the proliferation and survival of naïve CD4{sup +} cells upon anti-CD3 stimulation. We next discovered that IL-2 production and NF-κB activity after anti-CD3 stimulation were significantly elevated in Id1-expressing cells, which may be, at least in part, responsible for the augmentation of their proliferation and survival. Taken together, results from this study suggest an important role of E and Id proteins in peripheral T cell activation. The ability of Id proteins to by-pass co-stimulatory signals to enable T cell activation has significant implications in regulating T cell immunity.
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The Role of Project Science in the Chandra X-Ray Observatory
O'Dell, Stephen L.; Weisskopf, Martin C.
2006-01-01
The Chandra X-Ray Observatory, one of NASA's Great Observatories, has an outstanding record of scientific and technical success. This success results from the efforts of a team comprising NASA, its contractors, the Smithsonian Astrophysical Observatory, the instrument groups, and other elements of the scientific community, including thousands of scientists who utilize this powerful facility for astrophysical research. We discuss the role of NASA Project Science in the formulation, development, calibration, and operation of the Chandra X-ray Observatory. In addition to representing the scientific community within the Project, Project Science performed what we term "science systems engineering". This activity encompasses translation of science requirements into technical requirements and assessment of the scientific impact of programmatic and technical trades. We briefly describe several examples of science systems engineering conducted by Chandra Project Science.
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Chase, Z.; Bowie, A. R.; Blain, S.; Holmes, T.; Rayner, M.; Sherrin, K.; Tonnard, M.; Trull, T. W.
2016-12-01
The Kerguelen plateau in the Southern Indian Ocean is a naturally iron-fertilised region surrounded by iron-limited, High Nutrient Low Chlorophyll waters. The Heard Earth Ocean Biosphere Interaction (HEOBI) project sampled waters south of the Polar Front in the vicinity of Heard and McDonald Islands (HIMI) in January and February 2016. Fe fertilised waters over the plateau generally exhibited high phytoplankton biomass and photosynthetic competency (as in previous studies and satellite observations), but interestingly, phytoplankton biomass was low near HIMI, though photosynthetic competency was high. In plateau waters away from HIMI, silicic acid (Si) concentrations were strongly depleted in surface waters, averaging 3 μM, while nitrate concentrations were close to 25 μM. Relative to the remnant winter water, this represents an average seasonal drawdown of 32 μM Si and only 8 μM nitrate. Though absolute drawdown was lower at an HNLC reference site south of Heard Island, the drawdown ratio was similarly high (ΔSi: ΔN 4-5). The average N:P drawdown ratio was 12, typical for a diatom-dominated system (Weber and Deutsch 2010). N:P drawdown was positively correlated with Si drawdown, perhaps indicative of an impact of Fe on both seasonal Si drawdown and diatom N:P uptake (Price 2005). In the well-mixed, shallow waters (McDonald Islands, despite the apparent lack of nutrient drawdown or biomass accumulation. Mixed layers deeper than the euphotic zone are one mechanism that retains these remineralization signatures and near the islands, tidal mixing also contributes.
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Revocable ID-Based Signature with Short Size over Lattices
Directory of Open Access Journals (Sweden)
Ying-Hao Hung
2017-01-01
Full Text Available In the past, many ID-based signature (IBS schemes based on the integer factorization or discrete logarithm problems were proposed. With the progress on the development of quantum technology, IBS schemes mentioned above would become vulnerable. Recently, several IBS schemes over lattices were proposed to be secure against attacks in the quantum era. As conventional public-key settings, ID-based public-key settings have to offer a revocation mechanism to revoke misbehaving or malicious users. However, in the past, little work focuses on the revocation problem in the IBS schemes over lattices. In this article, we propose a new revocable IBS (RIBS scheme with short size over lattices. Based on the short integer solution (SIS assumption, we prove that the proposed RIBS scheme provides existential unforgeability against adaptive chosen-message attacks. As compared to the existing IBS schemes over lattices, our RIBS scheme has better performance in terms of signature size, signing key size, and the revocation mechanism with public channels.
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Assessment of the relationship between ACE I/D gene polymorphism and renal allograft survival.
Yang, Chun-Hua; Lu, Yi; Chen, Xue-Xia; Xian, Wen-Feng; Tu, Wei-Feng; Li, Hong-Yan
2015-12-01
The relationship between the angiotensin-converting enzyme (ACE) insertion/deletion (I/D) gene polymorphism and renal allograft survival after renal transplantation from the published reports are still debatable. This study was performed to evaluate the relationship between the ACE I/D gene polymorphism and renal allograft survival after renal transplantation using meta-analysis. Eligible studies were identified from PubMed and Cochrane Library on 1 November 2014, and eligible studies were recruited and synthesized using a meta-analysis methodology. Twelve investigations were included in this meta-analysis for the assessment of the relationship between the ACE I/D gene polymorphism and renal allograft survival. In this meta-analysis, the ACE I/D gene polymorphism was not associated with renal allograft survival after renal transplantation for overall populations, Caucasians, Brazilians and Africans. Interestingly, the ACE D allele and DD genotype were associated with renal allograft survival after renal transplantation in the Asian population. ACE D allele and DD genotype were associated with renal allograft survival after renal transplantation in the Asian population. However, more studies should be performed to confirm this association. © The Author(s) 2015.
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Identification of clinical yeasts by Vitek MS system compared with API ID 32 C.
Durán-Valle, M Teresa; Sanz-Rodríguez, Nuria; Muñoz-Paraíso, Carmen; Almagro-Moltó, María; Gómez-Garcés, José Luis
2014-05-01
We performed a clinical evaluation of the Vitek MS matrix-assisted laser desorption ionization-time-of-flight mass spectrometry (MALDI-TOF MS) system with the commercial database version 2.0 for rapid identification of medically important yeasts as compared with the conventional phenotypic method API ID 32 C. We tested 161 clinical isolates, nine isolates from culture collections and five reference strains. In case of discrepant results or no identification with one or both methods, molecular identification techniques were employed. Concordance between both methods was observed with 160/175 isolates (91.42%) and misidentifications by both systems occurred only when taxa were not included in the respective databases, i.e., one isolate of Candida etchellsii was identified as C. globosa by Vitek MS and two isolates of C. orthopsilosis were identified as C. parapsilosis by API ID 32 C. Vitek MS could not identify nine strains (5.14%) and API ID 32 C did not identify 13 (7.42%). Vitek MS was more reliable than API ID 32 C and reduced the time required for the identification of clinical isolates to only a few minutes.
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DEFF Research Database (Denmark)
Gibbs-Seymour, Ian; Oka, Yasuyoshi; Rajendra, Eeson
2015-01-01
We show that central components of the Fanconi anemia (FA) DNA repair pathway, the tumor suppressor proteins FANCI and FANCD2 (the ID complex), are SUMOylated in response to replication fork stalling. The ID complex is SUMOylated in a manner that depends on the ATR kinase, the FA ubiquitin ligase...
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Utilizing Internet Technologies in Observatory Control Systems
Cording, Dean
2002-12-01
The 'Internet boom' of the past few years has spurred the development of a number of technologies to provide services such as secure communications, reliable messaging, information publishing and application distribution for commercial applications. Over the same period, a new generation of computer languages have also developed to provide object oriented design and development, improved reliability, and cross platform compatibility. Whilst the business models of the 'dot.com' era proved to be largely unviable, the technologies that they were based upon have survived and have matured to the point were they can now be utilized to build secure, robust and complete observatory control control systems. This paper will describe how Electro Optic Systems has utilized these technologies in the development of its third generation Robotic Observatory Control System (ROCS). ROCS provides an extremely flexible configuration capability within a control system structure to provide truly autonomous robotic observatory operation including observation scheduling. ROCS was built using Internet technologies such as Java, Java Messaging Service (JMS), Lightweight Directory Access Protocol (LDAP), Secure Sockets Layer (SSL), eXtendible Markup Language (XML), Hypertext Transport Protocol (HTTP) and Java WebStart. ROCS was designed to be capable of controlling all aspects of an observatory and be able to be reconfigured to handle changing equipment configurations or user requirements without the need for an expert computer programmer. ROCS consists of many small components, each designed to perform a specific task, with the configuration of the system specified using a simple meta language. The use of small components facilitates testing and makes it possible to prove that the system is correct.
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South African Astronomical Observatory
International Nuclear Information System (INIS)
1987-01-01
Work at the South African Astronomical Observatory (SAAO) in recent years, by both staff and visitors, has made major contributions to the fields of astrophysics and astronomy. During 1986 the SAAO has been involved in studies of the following: galaxies; celestial x-ray sources; magellanic clouds; pulsating variables; galactic structure; binary star phenomena; nebulae and interstellar matter; stellar astrophysics; open clusters; globular clusters, and solar systems
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The Atsa Suborbital Observatory: An Observatory for a Commercial Suborbital Spacecraft
Vilas, F.; Sollitt, L. S.
2012-12-01
The advantages of astronomical observations made above Earth's atmosphere have long been understood: free access to spectral regions inaccessible from Earth (e.g., UV) or affected by the atmosphere's content (e.g., IR). Most robotic, space-based telescopes maintain large angular separation between the Sun and an observational target in order to avoid accidental damage to instruments from the Sun. For most astronomical targets, this possibility is easily avoided by waiting until objects are visible away from the Sun. For the Solar System objects inside Earth's orbit, this is never the case. Suborbital astronomical observations have over 50 years' history using NASA's sounding rockets and experimental space planes. Commercial suborbital spacecraft are largely expected to go to ~100 km altitude above Earth, providing a limited amount of time for astronomical observations. The unique scientific advantage to these observations is the ability to point close to the Sun: if a suborbital spacecraft accidentally turns too close to the Sun and fries an instrument, it is easy to land the spacecraft and repair the hardware for the next flight. Objects uniquely observed during the short observing window include inner-Earth asteroids, Mercury, Venus, and Sun-grazing comets. Both open-FOV and target-specific observations are possible. Despite many space probes to the inner Solar System, scientific questions remain. These include inner-Earth asteroid size and bulk density informing Solar System evolution studies and efforts to develop methods of mitigation against imminent impactors to Earth; chemistry and dynamics of Venus' atmosphere addressing physical phenomena such as greenhouse effect, atmospheric super-rotation and global resurfacing on Venus. With the Atsa Suborbital Observatory, we combine the strengths of both ground-based observatories and space-based observing to create a facility where a telescope is maintained and used interchangeably with both in-house facility
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Geoelectric monitoring at the Boulder magnetic observatory
Directory of Open Access Journals (Sweden)
C. C. Blum
2017-11-01
Full Text Available Despite its importance to a range of applied and fundamental studies, and obvious parallels to a robust network of magnetic-field observatories, long-term geoelectric field monitoring is rarely performed. The installation of a new geoelectric monitoring system at the Boulder magnetic observatory of the US Geological Survey is summarized. Data from the system are expected, among other things, to be used for testing and validating algorithms for mapping North American geoelectric fields. An example time series of recorded electric and magnetic fields during a modest magnetic storm is presented. Based on our experience, we additionally present operational aspects of a successful geoelectric field monitoring system.
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High Energy Astronomy Observatory (HEAO)-2
1982-01-01
This artist's concept depicts the High Energy Astronomy Observatory (HEAO)-2 in orbit. The HEAO-2, the first imaging and largest x-ray telescope built to date, was capable of producing actual photographs of x-ray objects. Shortly after launch, the HEAO-2 was nicknamed the Einstein Observatory by its scientific experimenters in honor of the centernial of the birth of Albert Einstein, whose concepts of relativity and gravitation have influenced much of modern astrophysics, particularly x-ray astronomy. The HEAO-2, designed and developed by TRW, Inc. under the project management of the Marshall Space Flight Center, was launched aboard an Atlas/Centaur launch vehicle on November 13, 1978. The HEAO-2 was originally identified as HEAO-B but the designation was changed once the spacecraft achieved orbit.
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The Danish eID Case: Twenty years of Delay
DEFF Research Database (Denmark)
Hoff, Jens Villiam; Hoff, Frederik Villiam
2010-01-01
the technological, organizational and legal dimensions of eID in Denmark, and comparing these with a number of other European countries made it possible to explain this paradox. Thus, the three main reasons for the special route development has taken in Denmark seems to be concerns over privacy, lack...
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Jantar Mantar: Observatories of Jai Singh (with pop-up pages)
Indian Academy of Sciences (India)
BOOK REVIEW. Jantar Mantar: Observatories of Jai. Singh (with pop-up pages). Biman Nath. Jantar Mantar: Observatories of Jai Singh. By: B S Shylaja and V S S Sastry. Bilingual Edition: English and Kannada. Published by Bangalore Association for. Science Education, Price:|500. Most of us have looked at the giant ...
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A search for stars of very low metal abundance. VI. Detailed abundances of 313 metal-poor stars
International Nuclear Information System (INIS)
Roederer, Ian U.; Preston, George W.; Thompson, Ian B.; Shectman, Stephen A.; Burley, Gregory S.; Kelson, Daniel D.; Sneden, Christopher
2014-01-01
We present radial velocities, equivalent widths, model atmosphere parameters, and abundances or upper limits for 53 species of 48 elements derived from high resolution optical spectroscopy of 313 metal-poor stars. A majority of these stars were selected from the metal-poor candidates of the HK Survey of Beers, Preston, and Shectman. We derive detailed abundances for 61% of these stars for the first time. Spectra were obtained during a 10 yr observing campaign using the Magellan Inamori Kyocera Echelle spectrograph on the Magellan Telescopes at Las Campanas Observatory, the Robert G. Tull Coudé Spectrograph on the Harlan J. Smith Telescope at McDonald Observatory, and the High Resolution Spectrograph on the Hobby-Eberly Telescope at McDonald Observatory. We perform a standard LTE abundance analysis using MARCS model atmospheres, and we apply line-by-line statistical corrections to minimize systematic abundance differences arising when different sets of lines are available for analysis. We identify several abundance correlations with effective temperature. A comparison with previous abundance analyses reveals significant differences in stellar parameters, which we investigate in detail. Our metallicities are, on average, lower by ≈0.25 dex for red giants and ≈0.04 dex for subgiants. Our sample contains 19 stars with [Fe/H] ≤–3.5, 84 stars with [Fe/H] ≤–3.0, and 210 stars with [Fe/H] ≤–2.5. Detailed abundances are presented here or elsewhere for 91% of the 209 stars with [Fe/H] ≤–2.5 as estimated from medium resolution spectroscopy by Beers, Preston, and Shectman. We will discuss the interpretation of these abundances in subsequent papers.
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Hardersen, P. S.; de Silva, S.; Reddy, V.; Cui, P.; Kumar, S.; Gaffey, M. J.
2006-06-01
One of the challenges in astronomy education today is to introduce college students to the real-world practice and science of observational astronomy. Along with a good theoretical background, college students can gain an earlier, deeper understanding of the astronomy profession through direct observational and data reduction experience. However, building and managing a modest observatory is still too costly for many colleges and universities. Fortunately, advances in commercial astronomical hardware and software now allow universities to build and operate small Internet controllable observatories for a modest investment. The advantages of an Internet observatory include: 1) remote operation from a comfortable location, 2) immediate data access, 3) telescope control via a web browser, and 4) allowing both on-campus and distance education students the ability to conduct a variety of observing projects. Internet capabilities vastly expand the number of students who will be able to use the observatory, thus exposing them to astronomy as a science and as a potential career. In September 2005, the University of North Dakota (UND) Department of Space Studies began operating a small, recently renovated Internet controllable observatory. Housed within a roll-off roof 10 miles west of UND, the observatory includes a Meade 16-inch, f/10 Schmidt-Cassegrain telescope, an SBIG STL-6303e CCD with broadband filters, ACP observatory control software, focuser, and associated equipment. The observatory cost \\25,000 to build in 1996; 2005 renovation costs total \\28,000. An observatory operator prepares the telescope for use each night. Through remote operation, the roof is opened and the telescope/CCD power is turned on. The telescope is then aligned and focused before allowing students to access the observatory. Students communicate with the observatory operator via an online chat room and via telephone, if necessary, to answer questions and resolve any problems. Additional