Sample records for maximum shortening velocity

  1. A critical examination of the maximum velocity of shortening used in simulation models of human movement.

    Domire, Zachary J; Challis, John H


    The maximum velocity of shortening of a muscle is an important parameter in musculoskeletal models. The most commonly used values are derived from animal studies; however, these values are well above the values that have been reported for human muscle. The purpose of this study was to examine the sensitivity of simulations of maximum vertical jumping performance to the parameters describing the force-velocity properties of muscle. Simulations performed with parameters derived from animal studies were similar to measured jump heights from previous experimental studies. While simulations performed with parameters derived from human muscle were much lower than previously measured jump heights. If current measurements of maximum shortening velocity in human muscle are correct, a compensating error must exist. Of the possible compensating errors that could produce this discrepancy, it was concluded that reduced muscle fibre excursion is the most likely candidate.

  2. Fiber type composition and maximum shortening velocity of muscles crossing the human shoulder.

    Srinivasan, R C; Lungren, M P; Langenderfer, J E; Hughes, R E


    A study of the fiber type composition of fourteen muscles spanning the human glenohumeral joint was carried out with the purpose of determining the contribution of fiber types to overall muscle cross-sectional area (CSA) and to estimate the maximum shortening velocity (V(max)) of those muscles. Muscle biopsies were procured from 4 male cadavers (mean age 50) within 24 hr of death, snap frozen, mounted, and transversely sectioned (10 microm). Slides were stained for myofibrillar ATPase after alkaline preincubation. Photoimages were taken of defined areas (100 fibers) using the Bioquant system, and fiber type and CSA were measured from these images. Staining for mATPase produced three different fiber types: slow-oxidative (SO), fast-oxidative-glycolytic (FOG), and fast-glycolytic (FG). On average, the muscle fiber type composition ranged from 22 to 40% of FG, from 17 to 51% of FOG, and from 23 to 56% of SO. Twelve out of the 14 muscles had average SO proportions ranging from 35 to 50%. V(max) was calculated from the fiber type contribution relative to CSA and shortening velocity values taken from the literature. The maximum velocities of shortening presented here provide a physiological basis for the development of human shoulder musculoskeletal models suitable for predicting muscle forces for functionally relevant tasks encompassing conditions of muscle shortening and lengthening.

  3. Maximum shortening velocity of lymphatic muscle approaches that of striated muscle.

    Zhang, Rongzhen; Taucer, Anne I; Gashev, Anatoliy A; Muthuchamy, Mariappan; Zawieja, David C; Davis, Michael J


    Lymphatic muscle (LM) is widely considered to be a type of vascular smooth muscle, even though LM cells uniquely express contractile proteins from both smooth muscle and cardiac muscle. We tested the hypothesis that LM exhibits an unloaded maximum shortening velocity (Vmax) intermediate between that of smooth muscle and cardiac muscle. Single lymphatic vessels were dissected from the rat mesentery, mounted in a servo-controlled wire myograph, and subjected to isotonic quick release protocols during spontaneous or agonist-evoked contractions. After maximal activation, isotonic quick releases were performed at both the peak and plateau phases of contraction. Vmax was 0.48 ± 0.04 lengths (L)/s at the peak: 2.3 times higher than that of mesenteric arteries and 11.4 times higher than mesenteric veins. In cannulated, pressurized lymphatic vessels, shortening velocity was determined from the maximal rate of constriction [rate of change in internal diameter (-dD/dt)] during spontaneous contractions at optimal preload and minimal afterload; peak -dD/dt exceeded that obtained during any of the isotonic quick release protocols (2.14 ± 0.30 L/s). Peak -dD/dt declined with pressure elevation or activation using substance P. Thus, isotonic methods yielded Vmax values for LM in the mid to high end (0.48 L/s) of those the recorded for phasic smooth muscle (0.05-0.5 L/s), whereas isobaric measurements yielded values (>2.0 L/s) that overlapped the midrange of values for cardiac muscle (0.6-3.3 L/s). Our results challenge the dogma that LM is classical vascular smooth muscle, and its unusually high Vmax is consistent with the expression of cardiac muscle contractile proteins in the lymphatic vessel wall.

  4. The maximum velocity of shortening during the early phases of the contraction in frog single muscle fibres.

    Lombardi, V; Menchetti, G


    The maximum velocity of shortening (Vmax) was determined at preset times during the development and the plateau of isometric tetani in single fibres isolated from the tibialis anterior muscle of the frog. Experiments were performed at low temperature (3.6-6 degrees C) and at about 2.25 micron sarcomere length. The controlled velocity release method was used. Vmax was measured by determining the lowest velocity of release required to keep the tension at zero. Extreme care was taken in dissection and mounting of the fibres in order to make the passive series compliance very small. The value of Vmax at the end of the latent period for the development of isometric tension (at 4.5 degrees C about 10 ms after the beginning of the stimulus volley) was already the same as later during either the tension rise or at the plateau of isometric tetani. These results show that the value of Vmax of intact fibres is independent of time and activation subsequent to the latent period, and suggest that the cycling rate of the crossbridges may thus attain its steady-state value just at the end of the isometric latent period.

  5. Minimum Length - Maximum Velocity

    Panes, Boris


    We study a framework where the hypothesis of a minimum length in space-time is complemented with the notion of reference frame invariance. It turns out natural to interpret the action of the obtained reference frame transformations in the context of doubly special relativity. As a consequence of this formalism we find interesting connections between the minimum length properties and the modified velocity-energy relation for ultra-relativistic particles. For example we can predict the ratio between the minimum lengths in space and time using the results from OPERA about superluminal neutrinos.

  6. Changes in the maximum speed of shortening of frog muscle fibres early in a tetanic contraction and during relaxation.

    Josephson, R K; Edman, K A


    1. Isotonic shortening velocities at very light loads were examined in single fibres of the anterior tibialis muscle of the frog, Rana temporaria, using load-clamp recording and slack tests (temperature, 1-3 degrees C; initial sarcomere length, 2.25 microns). 2. Shortening velocities at very light loads (force-clamp recording) were found to be higher early in the rise of a tetanic contraction than during the plateau of the contraction. The upper limit of the load at which there was elevated shortening velocity early in the contraction was 1.5-5.4% of the maximum tetanic tension (Fo) depending on the particular fibre. 3. The maximum shortening velocity determined using the slack test method (Vo) was as much as 30% greater early in a contraction than at the tetanic plateau. Vo was elevated above the plateau level up to about 30 ms after the end of the latent period, which is equivalent to the time required for the force in an isometric contraction to rise to about 30% of Fo. Vo is depressed below the plateau value during relaxation at the cessation of stimulation. 4. Stimulation studies show that the cross-bridge model of Huxley (1957) predicts the maximum shortening velocity to be greater early in a contraction, when new actin binding sites are becoming activated and new cross-bridge connections are being formed rapidly, than during steady-state contraction. The elevated shortening velocity in the model is a consequence of new cross-bridges being formed in the pulling configuration, and there being a delay before the newly added bridges are dragged beyond their equilibrium position so they begin to retard shortening. The model also predicts that maximum shortening velocity should be depressed below the plateau level during early relaxation as cross-bridge binding sites are rapidly removed from the active population.

  7. Estimation of circumferential fiber shortening velocity by echocardiography.

    Ruschhaupt, D G; Sodt, P C; Hutcheon, N A; Arcilla, R A


    The M-mode and two-dimensional echocardiograms of 40 young patients were analyzed to compare the mean circumferential fiber shortening velocity (Vcf) of the left ventricle calculated separately by two methods. The mean circumferential fiber shortening velocity was derived from the M-mode echocardiogram as minor axis shortening/ejection time and derived from the two-dimensional echocardiogram as actual circumference change/ejection time. With computer assistance, circumference was determined from the short-axis two-dimensional echocardiographic images during end-diastole and end-systole. Good correlations were obtained between the left ventricular diameter derived by M-mode echocardiography and the vertical axis during end-diastole (r = 0.79) and end-systole (r = 0.88) derived by two-dimensional echocardiography. Likewise, high correlations were noted between diameter and circumference in end-diastole (r = 0.89) and end-systole (r = 0.88). However, comparison of Vcf obtained by M-mode echocardiography with that obtained by two-dimensional echocardiography showed only fair correlation (r = 0.68). Moreover, the diameter/circumference ratio determined in end-diastole and end-systole differed significantly (p less than 0.001), possibly owing to the change in geometry of the ventricular sector image during systole. Although Vcf derived by M-mode echocardiography is a useful index of left ventricular performance, it does not truly reflect the circumference change during systole.

  8. Relationships between muscle power output using the stretch-shortening cycle and eccentric maximum strength.

    Miyaguchi, Kazuyoshi; Demura, Shinichi


    This study aimed to examine the relationships between muscle power output using the stretch-shortening cycle (SSC) and eccentric maximum strength under elbow flexion. Eighteen young adult males pulled up a constant light load (2 kg) by ballistic elbow flexion under the following two preliminary conditions: 1) the static relaxed muscle state (SR condition), and 2) using the SSC with countermovement (SSC condition).Muscle power was determined from the product of the pulling velocity and the load mass by a power measurement instrument that adopted the weight-loading method. We assumed the pulling velocity to be the subject's muscle power parameters as a matter of convenience, because we used a constant load. The following two parameters were selected in reference to a previous study: 1) peak velocity (m x s(-1)) (peak power) and 2) 0.1-second velocity during concentric contraction (m x s(-1)) (initial power). Eccentric maximum strength by elbow flexion was measured by a handheld dynamometer.Initial power produced in the SSC condition was significantly larger than that in the SR condition. Eccentric maximum strength showed a significant and high correlation (r = 0.70) with peak power in the SSC condition but not in the SR condition. Eccentric maximum strength showed insignificant correlations with initial power in both conditions. In conclusion, it was suggested that eccentric maximum strength is associated with peak power in the SSC condition, but the contribution of the eccentric maximum strength to the SSC potentiation (initial power) may be low.

  9. Minimum length-maximum velocity

    Panes, Boris


    We study a framework where the hypothesis of a minimum length in space-time is complemented with the notion of reference frame invariance. It turns out natural to interpret the action of the obtained reference frame transformations in the context of doubly special relativity. As a consequence of this formalism we find interesting connections between the minimum length properties and the modified velocity-energy relation for ultra-relativistic particles. For example, we can predict the ratio between the minimum lengths in space and time using the results from OPERA on superluminal neutrinos.

  10. Relative shortening velocity in locomotor muscles: turkey ankle extensors operate at low V/V(max).

    Gabaldón, Annette M; Nelson, Frank E; Roberts, Thomas J


    The force-velocity properties of skeletal muscle have an important influence on locomotor performance. All skeletal muscles produce less force the faster they shorten and typically develop maximal power at velocities of approximately 30% of maximum shortening velocity (V(max)). We used direct measurements of muscle mechanical function in two ankle extensor muscles of wild turkeys to test the hypothesis that during level running muscles operate at velocities that favor force rather than power. Sonomicrometer measurements of muscle length, tendon strain-gauge measurements of muscle force, and bipolar electromyographs were taken as animals ran over a range of speeds and inclines. These measurements were integrated with previously measured values of muscle V(max) for these muscles to calculate relative shortening velocity (V/V(max)). At all speeds for level running the V/V(max) values of the lateral gastrocnemius and the peroneus longus were low (muscles were capable of producing 90% of peak isometric force but only 35% of peak isotonic power. V/V(max) increased in response to the demand for mechanical power with increases in running incline and decreased to negative values to absorb energy during downhill running. Measurements of integrated electromyograph activity indicated that the volume of muscle required to produce a given force increased from level to uphill running. This observation is consistent with the idea that V/V(max) is an important determinant of locomotor cost because it affects the volume of muscle that must be recruited to support body weight.

  11. Accumulating evidence for increased velocity of airway smooth muscle shortening in asthmatic airway hyperresponsiveness.

    Ijpma, Gijs; Matusovsky, Oleg; Lauzon, Anne-Marie


    It remains unclear whether airway smooth muscle (ASM) mechanics is altered in asthma. While efforts have originally focussed on contractile force, some evidence points to an increased velocity of shortening. A greater rate of airway renarrowing after a deep inspiration has been reported in asthmatics compared to controls, which could result from a shortening velocity increase. In addition, we have recently shown in rats that increased shortening velocity correlates with increased muscle shortening, without increasing muscle force. Nonetheless, establishing whether or not asthmatic ASM shortens faster than that of normal subjects remains problematic. Endobronchial biopsies provide excellent tissue samples because the patients are well characterized, but the size of the samples allows only cell level experiments. Whole human lungs from transplant programs suffer primarily from poor patient characterization, leading to high variability. ASM from several animal models of asthma has shown increased shortening velocity, but it is unclear whether this is representative of human asthma. Several candidates have been suggested as responsible for increased shortening velocity in asthma, such as alterations in contractile protein expression or changes in the contractile apparatus structure. There is no doubt that more remains to be learned about the role of shortening velocity in asthma.

  12. In vivo maximal fascicle-shortening velocity during plantar flexion in humans.

    Hauraix, Hugo; Nordez, Antoine; Guilhem, Gaël; Rabita, Giuseppe; Dorel, Sylvain


    Interindividual variability in performance of fast movements is commonly explained by a difference in maximal muscle-shortening velocity due to differences in the proportion of fast-twitch fibers. To provide a better understanding of the capacity to generate fast motion, this study aimed to 1) measure for the first time in vivo the maximal fascicle-shortening velocity of human muscle; 2) evaluate the relationship between angular velocity and fascicle-shortening velocity from low to maximal angular velocities; and 3) investigate the influence of musculo-articular features (moment arm, tendinous tissues stiffness, and muscle architecture) on maximal angular velocity. Ultrafast ultrasound images of the gastrocnemius medialis were obtained from 31 participants during maximal isokinetic and light-loaded plantar flexions. A strong linear relationship between fascicle-shortening velocity and angular velocity was reported for all subjects (mean R(2) = 0.97). The maximal shortening velocity (V(Fmax)) obtained during the no-load condition (NLc) ranged between 18.8 and 43.3 cm/s. V(Fmax) values were very close to those of the maximal shortening velocity (V(max)), which was extrapolated from the F-V curve (the Hill model). Angular velocity reached during the NLc was significantly correlated with this V(Fmax) (r = 0.57; P < 0.001). This finding was in agreement with assumptions about the role of muscle fiber type, whereas interindividual comparisons clearly support the fact that other parameters may also contribute to performance during fast movements. Nevertheless, none of the biomechanical features considered in the present study were found to be directly related to the highest angular velocity, highlighting the complexity of the upstream mechanics that lead to maximal-velocity muscle contraction.

  13. Could an increase in airway smooth muscle shortening velocity cause airway hyperresponsiveness?

    Bullimore, Sharon R; Siddiqui, Sana; Donovan, Graham M; Martin, James G; Sneyd, James; Bates, Jason H T; Lauzon, Anne-Marie


    Airway hyperresponsiveness (AHR) is a characteristic feature of asthma. It has been proposed that an increase in the shortening velocity of airway smooth muscle (ASM) could contribute to AHR. To address this possibility, we tested whether an increase in the isotonic shortening velocity of ASM is associated with an increase in the rate and total amount of shortening when ASM is subjected to an oscillating load, as occurs during breathing. Experiments were performed in vitro using 27 rat tracheal ASM strips supramaximally stimulated with methacholine. Isotonic velocity at 20% isometric force (Fiso) was measured, and then the load on the muscle was varied sinusoidally (0.33 ± 0.25 Fiso, 1.2 Hz) for 20 min, while muscle length was measured. A large amplitude oscillation was applied every 4 min to simulate a deep breath. We found that: 1) ASM strips with a higher isotonic velocity shortened more quickly during the force oscillations, both initially (P shortening during the force oscillation protocol (P shortening with increased isotonic velocity could be explained by a change in either the cycling rate of phosphorylated cross bridges or the rate of myosin light chain phosphorylation. We conclude that, if asthma involves an increase in ASM velocity, this could be an important factor in the associated AHR.

  14. [Comparison of force and shortening velocity in fast and slow rabbit muscle fibers at different temperatures].

    Kochubeĭ, P V; Bershitskiĭ, S Iu


    The temperature dependence of force, maximal shortening velocity and power of maximally activated single permeabilized fibers from fast and slow muscles of the rabbit were recorded in a temperature range from 10 to 35 degrees C with 5 degrees C step. It was found that temperature dependence of force of both types of fibers is identical. Averaged maximal shortening velocity in the slow fibers, unlike the fast fibers, had no statistically significant temperature dependence that is not in agreement with the data obtained on intact rat muscle fibers and in an in vitro motility assay. However maximal shortening velocity in each individual slow fiber did depend on temperature. The temperature dependence of power of the slow fibers was lower than that of the fast ones. Because of large data scattering the average temperature dependence of power of the slow fibers was significantly lower than that in individual slow fibers.

  15. Single rabbit stomach smooth muscle cell myosin heavy chain SMB expression and shortening velocity.

    Eddinger, T J; Meer, D P


    Isolated single smooth muscle cells (SMCs) from different regions of the rabbit stomach were used to determine a possible correlation between unloaded shortening velocity and smooth muscle (SM) myosin heavy chain (MHC) S1 head isoform composition (SMA, no head insert; SMB, with head insert). alpha-Toxin-permeabilized isolated single cells were maximally activated to measure unloaded shortening velocity and subsequently used in an RT-PCR reaction to determine the SMA/SMB content of the same cell. SM MHC SMA and SMB isoforms are uniquely distributed in the stomach with cells from the fundic region expressing little SMB (38.1 +/- 7.3% SMB; n = 16); cells from the antrum express primarily SMB (94.9 +/- 1.0% SMB; n = 16). Mean fundic cell unloaded shortening velocity was 0.014 +/- 0.002 cell lengths/s compared with 0.036 +/- 0.002 for the antrum cells. Unloaded shortening velocity in these cells was significantly correlated with their percent SMB expression (r2 = 0.58). Resting cell length does not correlate with the percent SMB expression (n = 32 cells). Previously published assays of purified or expressed SMA and SMB heavy meromyosin show a twofold difference in actin filament sliding speed in in vitro motility assays. Extrapolation of our data to 0-100% SMB would give a 10-fold range of shortening velocity, which is closer to the approximately 20-fold range reported from various SM tissues. This suggests that mechanisms in addition to the MHC S1 head isoforms regulate shortening velocity.

  16. Response of slow and fast muscle to hypothyroidism: maximal shortening velocity and myosin isoforms

    Caiozzo, V. J.; Herrick, R. E.; Baldwin, K. M.


    This study examined both the shortening velocity and myosin isoform distribution of slow- (soleus) and fast-twitch (plantaris) skeletal muscles under hypothyroid conditions. Adult female Sprague-Dawley rats were randomly assigned to one of two groups: control (n = 7) or hypothyroid (n = 7). In both muscles, the relative contents of native slow myosin (SM) and type I myosin heavy chain (MHC) increased in response to the hypothyroid treatment. The effects were such that the hypothyroid soleus muscle expressed only the native SM and type I MHC isoforms while repressing native intermediate myosin and type IIA MHC. In the plantaris, the relative content of native SM and type I MHC isoforms increased from 5 to 13% and from 4 to 10% of the total myosin pool, respectively. Maximal shortening velocity of the soleus and plantaris as measured by the slack test decreased by 32 and 19%, respectively, in response to hypothyroidism. In contrast, maximal shortening velocity as estimated by force-velocity data decreased only in the soleus (-19%). No significant change was observed for the plantaris.

  17. Influence of the heart rate on mean circumferential shortening velocity: echocardiographic study of 183 normal subjects.

    Mangiarotti, R; Martinotti, R; Monzani, V; Sardella, F; Pierini, A; Pastori, M; Randazzo, A


    Echocardiography was used to explore the influence of independent variables (age, body surface area and heart rate) on the mean circumferential shortening velocity (MVCF) in 183 healthy subjects. Multiple stepwise regression analysis shows that heart rate is the only variable of the three just mentioned that influences MVCF. A regression equation is evolved and proposed as an index of MVCF correction for varying heart rates.

  18. Calculation of muscle maximal shortening velocity by extrapolation of the force-velocity relationship: afterloaded versus isotonic release contractions.

    Bullimore, Sharon R; Saunders, Travis J; Herzog, Walter; MacIntosh, Brian R


    The maximal shortening velocity of a muscle (V(max)) provides a link between its macroscopic properties and the underlying biochemical reactions and is altered in some diseases. Two methods that are widely used for determining V(max) are afterloaded and isotonic release contractions. To determine whether these two methods give equivalent results, we calculated V(max) in 9 intact single fibres from the lumbrical muscles of the frog Xenopus laevis (9.5-15.5 °C, stimulation frequency 35-70 Hz). The data were modelled using a 3-state cross-bridge model in which the states were inactive, detached, and attached. Afterloaded contractions gave lower predictions of Vmax than did isotonic release contractions in all 9 fibres (3.20 ± 0.84 versus 4.11 ± 1.08 lengths per second, respectively; means ± SD, p = 0.001) and underestimated unloaded shortening velocity measured with the slack test by an average of 29% (p = 0.001, n = 6). Excellent model predictions could be obtained by assuming that activation is inhibited by shortening. We conclude that under the experimental conditions used in this study, afterloaded and isotonic release contractions do not give equivalent results. When a change in the V(max) measured with afterloaded contractions is observed in diseased muscle, it is important to consider that this may reflect differences in either activation kinetics or cross-bridge cycling rates.

  19. Unloaded shortening velocity of voluntarily and electrically activated human dorsiflexor muscles in vivo.

    Sasaki, Kazushige; Ishii, Naokata


    We have previously shown that unloaded shortening velocity (V(0)) of human plantar flexors can be determined in vivo, by applying the "slack test" to submaximal voluntary contractions (J Physiol 567:1047-1056, 2005). In the present study, to investigate the effect of motor unit recruitment pattern on V(0) of human muscle, we modified the slack test and applied this method to both voluntary and electrically elicited contractions of dorsiflexors. A series of quick releases (i.e., rapid ankle joint rotation driven by an electrical dynamometer) was applied to voluntarily activated dorsiflexor muscles at three different contraction intensities (15, 50, and 85% of maximal voluntary contraction; MVC). The quick-release trials were also performed on electrically activated dorsiflexor muscles, in which three stimulus conditions were used: submaximal (equal to 15%MVC) 50-Hz stimulation, supramaximal 50-Hz stimulation, and supramaximal 20-Hz stimulation. Modification of the slack test in vivo resulted in good reproducibility of V(0), with an intraclass correlation coefficient of 0.87 (95% confidence interval: 0.68-0.95). Regression analysis showed that V(0) of voluntarily activated dorsiflexor muscles significantly increased with increasing contraction intensity (R(2) = 0.52, Pmuscles remained unchanged (R(2)shortening velocity of human skeletal muscle in vivo.

  20. Temperature jump induced force generation in rabbit muscle fibres gets faster with shortening and shows a biphasic dependence on velocity.

    Ranatunga, K W; Roots, H; Offer, G W


    We examined the tension responses to ramp shortening and rapid temperature jump (muscle fibres at 8-9 degrees C (the fibre length (L(0)) was approximately 1.5 mm and sarcomere length 2.5 microm). The aim was to investigate the strain sensitivity of crossbridge force generation in muscle. The T-jump induced tension rise was examined during steady shortening over a wide range of velocities (V) approaching the V(max) (V range approximately 0.01 to approximately 1.5 L(0) s(1)). In the isometric state, a T-jump induced a biphasic tension rise consisting of a fast (approximately 50 s(1), phase 2b) and a slow (approximately 10 s(1), phase 3) component, but if treated as monophasic the rate was approximately 20 s(1). During steady shortening the T-jump tension rise was monophasic; the rate of tension rise increased linearly with shortening velocity, and near V(max) it was approximately 200 s(1), approximately 10x faster than in the isometric state. Relative to the tension reached after the T-jump, the amplitude increased with shortening velocity, and near V(max) it was 4x larger than in the isometric state. Thus, the temperature sensitivity of muscle force is markedly increased with velocity during steady shortening, as found in steady state experiments. The rate of tension decline during ramp shortening also increased markedly with increase of velocity. The absolute amplitude of T-jump tension rise was larger than that in the isometric state at the low velocities (shortening velocity is increased, probably enhancement of crossbridge force generation and faster (post-stroke) crossbridge detachment by negative strain. Overall, our results show that T-jump force generation is strain sensitive and becomes considerably faster when exposed to negative strain. Thus the crossbridge force generation step in muscle is both temperature sensitive (endothermic) and strain sensitive.

  1. Maximum tunneling velocities in symmetric double well potentials

    Manz, Jörn [State Key Laboratory of Quantum Optics and Quantum Optics Devices, Institute of Laser Spectroscopy, Shanxi University, 92, Wucheng Road, Taiyuan 030006 (China); Institut für Chemie und Biochemie, Freie Universität Berlin, Takustr. 3, 14195 Berlin (Germany); Schild, Axel [Institut für Chemie und Biochemie, Freie Universität Berlin, Takustr. 3, 14195 Berlin (Germany); Schmidt, Burkhard, E-mail: [Institut für Mathematik, Freie Universität Berlin, Arnimallee 6, 14195 Berlin (Germany); Yang, Yonggang, E-mail: [State Key Laboratory of Quantum Optics and Quantum Optics Devices, Institute of Laser Spectroscopy, Shanxi University, 92, Wucheng Road, Taiyuan 030006 (China)


    Highlights: • Coherent tunneling in one-dimensional symmetric double well potentials. • Potentials for analytical estimates in the deep tunneling regime. • Maximum velocities scale as the square root of the ratio of barrier height and mass. • In chemical physics maximum tunneling velocities are in the order of a few km/s. - Abstract: We consider coherent tunneling of one-dimensional model systems in non-cyclic or cyclic symmetric double well potentials. Generic potentials are constructed which allow for analytical estimates of the quantum dynamics in the non-relativistic deep tunneling regime, in terms of the tunneling distance, barrier height and mass (or moment of inertia). For cyclic systems, the results may be scaled to agree well with periodic potentials for which semi-analytical results in terms of Mathieu functions exist. Starting from a wavepacket which is initially localized in one of the potential wells, the subsequent periodic tunneling is associated with tunneling velocities. These velocities (or angular velocities) are evaluated as the ratio of the flux densities versus the probability densities. The maximum velocities are found under the top of the barrier where they scale as the square root of the ratio of barrier height and mass (or moment of inertia), independent of the tunneling distance. They are applied exemplarily to several prototypical molecular models of non-cyclic and cyclic tunneling, including ammonia inversion, Cope rearrangement of semibullvalene, torsions of molecular fragments, and rotational tunneling in strong laser fields. Typical maximum velocities and angular velocities are in the order of a few km/s and from 10 to 100 THz for our non-cyclic and cyclic systems, respectively, much faster than time-averaged velocities. Even for the more extreme case of an electron tunneling through a barrier of height of one Hartree, the velocity is only about one percent of the speed of light. Estimates of the corresponding time scales for

  2. Unloaded shortening velocity of voluntarily and electrically activated human dorsiflexor muscles in vivo.

    Kazushige Sasaki

    Full Text Available We have previously shown that unloaded shortening velocity (V(0 of human plantar flexors can be determined in vivo, by applying the "slack test" to submaximal voluntary contractions (J Physiol 567:1047-1056, 2005. In the present study, to investigate the effect of motor unit recruitment pattern on V(0 of human muscle, we modified the slack test and applied this method to both voluntary and electrically elicited contractions of dorsiflexors. A series of quick releases (i.e., rapid ankle joint rotation driven by an electrical dynamometer was applied to voluntarily activated dorsiflexor muscles at three different contraction intensities (15, 50, and 85% of maximal voluntary contraction; MVC. The quick-release trials were also performed on electrically activated dorsiflexor muscles, in which three stimulus conditions were used: submaximal (equal to 15%MVC 50-Hz stimulation, supramaximal 50-Hz stimulation, and supramaximal 20-Hz stimulation. Modification of the slack test in vivo resulted in good reproducibility of V(0, with an intraclass correlation coefficient of 0.87 (95% confidence interval: 0.68-0.95. Regression analysis showed that V(0 of voluntarily activated dorsiflexor muscles significantly increased with increasing contraction intensity (R(2 = 0.52, P<0.001. By contrast, V(0 of electrically activated dorsiflexor muscles remained unchanged (R(2<0.001, P = 0.98 among three different stimulus conditions showing a large variation of tetanic torque. These results suggest that the recruitment pattern of motor units, which is quite different between voluntary and electrically elicited contractions, plays an important role in determining shortening velocity of human skeletal muscle in vivo.

  3. Maximum tunneling velocities in symmetric double well potentials

    Manz, Jörn; Schmidt, Burkhard; Yang, Yonggang


    We consider coherent tunneling of one-dimensional model systems in non-cyclic or cyclic symmetric double well potentials. Generic potentials are constructed which allow for analytical estimates of the quantum dynamics in the non-relativistic deep tunneling regime, in terms of the tunneling distance, barrier height and mass (or moment of inertia). For cyclic systems, the results may be scaled to agree well with periodic potentials for which semi-analytical results in terms of Mathieu functions exist. Starting from a wavepacket which is initially localized in one of the potential wells, the subsequent periodic tunneling is associated with tunneling velocities. These velocities (or angular velocities) are evaluated as the ratio of the flux densities versus the probability densities. The maximum velocities are found under the top of the barrier where they scale as the square root of the ratio of barrier height and mass (or moment of inertia), independent of the tunneling distance. They are applied exemplarily to ...

  4. An analysis of the temperature dependence of force, during steady shortening at different velocities, in (mammalian) fast muscle fibres.

    Roots, H; Ranatunga, K W


    We examined, over a wide range of temperatures (10-35 degrees C), the isometric tension and tension during ramp shortening at different velocities (0.2-4 L(0)/s) in tetanized intact fibre bundles from a rat fast (flexor hallucis brevis) muscle; fibre length (L(0)) was 2.2 mm and sarcomere length approximately 2.5 microm. During a ramp shortening, the tension change showed an initial inflection of small amplitude (P(1)), followed by a larger exponential decline towards an approximate steady level; the tension continued to decline slowly afterwards and the approximate steady tension at a given velocity was estimated as the tension (P(2)) at the point of intersection between two linear slopes, as previously described (Roots et al. 2007). At a given temperature, the tension P(2) declined to a lower level and at a faster rate (from an exponential curve fit) as the shortening velocity was increased; the temperature sensitivity of the rate of tension decline during ramp shortening at different velocities was low (Q(10) 0.9-1.5). The isometric tension and the P(2) tension at a given shortening velocity increased with warming so that the relation between tension and (reciprocal) temperature was sigmoidal in both. In isometric muscle, the temperature T(0.5) for half-maximal tension was approximately 10 degrees C, activation enthalpy change (DeltaH) was approximately 100 kJ mol(-1) and entropy change (DeltaS) approximately 350 J mol(-1) K(-1). In shortening, these were increased with increase of velocity so that at a shortening velocity (approximately 4 L(0)/s) producing maximal power at 35 degrees C, T(0.5) was approximately 28 degrees C, DeltaH was approximately 200 kJ mol(-1) and DeltaS approximately 700 J mol(-1) K(-1); the same trends were seen in the tension data from isotonic release experiments on intact muscle and in ramp shortening experiments on maximally Ca-activated skinned fibres. In general, our findings show that the sigmoidal relation between force and

  5. Myosin heavy chain isoform expression regulates shortening velocity in smooth muscle: studies using an SMB KO mouse line.

    Karagiannis, Peter; Babu, G J; Periasamy, M; Brozovich, Frank V


    The kinetics of smooth muscle are thought to be partially determined by the level of the expression of the 7 amino acid insert, SMB, in the myosin heavy chain, as SMB is generally expressed at higher levels in faster smooth muscle. In this study, we determined the role of this insert on shortening velocity and force regeneration following rapid reduction in muscle length (k(step)) in bladder tissue from a transgenic mouse line expressing the insert at three different levels: wild type (WT, +/+, SMB/SMB), an SMA homozygous type (SMB KO, -/-), and a heterozygous type (+/-, SMB/SMA). Smooth muscle from +/+ bladder shorten faster than both the +/- and -/- bladder smooth muscle when activated with Ca2+, consistent with SMB determining the shortening velocity of smooth muscle. The addition of Pi to the fully activated skinned bladder strips did not affect the rate of shortening for either the +/+ or -/- bladder types but did significantly decrease the rate of shortening for the +/- type. In contrast, the addition of ADP to fully Ca2+ activated bladder strips increased the rate of shortening for all three bladder types. However after thiophosphorylation, ADP slowed the shortening velocity. These data are consistent with shortening velocity being determined by the level of activation (or crossbridge attachment) in smooth muscle. The rates of force regeneration according to the k(step) protocol showed no differences between bladder types and also proved insensitive to either Pi or ADP. These data suggest that the rates of force regeneration were determined not only by the kinetics of the crossbridge cycle, but also by factors outside the contractile apparatus.

  6. Maximum Velocities in Flexion and Extension Actions for Sport

    Jessop David M.


    Full Text Available Speed of movement is fundamental to the outcome of many human actions. A variety of techniques can be implemented in order to maximise movement speed depending on the goal of the movement, constraints, and the time available. Knowing maximum movement velocities is therefore useful for developing movement strategies but also as input into muscle models. The aim of this study was to determine maximum flexion and extension velocities about the major joints in upper and lower limbs. Seven university to international level male competitors performed flexion/extension at each of the major joints in the upper and lower limbs under three conditions: isolated; isolated with a countermovement; involvement of proximal segments. 500 Hz planar high speed video was used to calculate velocities. The highest angular velocities in the upper and lower limb were 50.0 rad·s-1 and 28.4 rad·s-1, at the wrist and knee, respectively. As was true for most joints, these were achieved with the involvement of proximal segments, however, ANOVA analysis showed few significant differences (p<0.05 between conditions. Different segment masses, structures and locations produced differing results, in the upper and lower limbs, highlighting the requirement of segment specific strategies for maximal movements.

  7. An approximate, maximum-terminal-velocity descent to a point

    Eisler, G. Richard; Hull, David G.

    A neighboring extremal control problem is formulated for a hypersonic glider to execute a maximum-terminal-velocity descent to a stationary target in a vertical plane. The resulting two-part, feedback control scheme initially solves a nonlinear algebraic problem to generate a nominal trajectory to the target altitude. Secondly, quadrature about the nominal provides the lift perturbation necessary to achieve the target downrange. On-line feedback simulations are run for the proposed scheme and a form of proportional navigation and compared with an off-line parameter optimization method. The neighboring extremal terminal velocity compares very well with the parameter optimization solution and is far superior to proportional navigation. However, the update rate is degraded, though the proposed method can be executed in real time.

  8. An approximate, maximum terminal velocity descent to a point

    Eisler, G.R.; Hull, D.G.


    No closed form control solution exists for maximizing the terminal velocity of a hypersonic glider at an arbitrary point. As an alternative, this study uses neighboring extremal theory to provide a sampled data feedback law to guide the vehicle to a constrained ground range and altitude. The guidance algorithm is divided into two parts: 1) computation of a nominal, approximate, maximum terminal velocity trajectory to a constrained final altitude and computation of the resulting unconstrained groundrange, and 2) computation of the neighboring extremal control perturbation at the sample value of flight path angle to compensate for changes in the approximate physical model and enable the vehicle to reach the on-board computed groundrange. The trajectories are characterized by glide and dive flight to the target to minimize the time spent in the denser parts of the atmosphere. The proposed on-line scheme successfully brings the final altitude and range constraints together, as well as compensates for differences in flight model, atmosphere, and aerodynamics at the expense of guidance update computation time. Comparison with an independent, parameter optimization solution for the terminal velocity is excellent. 6 refs., 3 figs.

  9. A continuum of myofibers in adult rabbit extraocular muscle: force, shortening velocity, and patterns of myosin heavy chain colocalization.

    McLoon, Linda K; Park, Han Na; Kim, Jong-Hee; Pedrosa-Domellöf, Fatima; Thompson, Ladora V


    Extraocular muscle (EOM) myofibers do not fit the traditional fiber typing classifications normally used in noncranial skeletal muscle, in part, due to the complexity of their individual myofibers. With single skinned myofibers isolated from rectus muscles of normal adult rabbits, force and shortening velocity were determined for 220 fibers. Each fiber was examined for myosin heavy chain (MyHC) isoform composition by densitometric analysis of electrophoresis gels. Rectus muscle serial sections were examined for coexpression of eight MyHC isoforms. A continuum was seen in single myofiber shortening velocities as well as force generation, both in absolute force (g) and specific tension (kN/m(2)). Shortening velocity correlated with MyHCIIB, IIA, and I content, the more abundant MyHC isoforms expressed within individual myofibers. Importantly, single fibers with similar or identical shortening velocities expressed significantly different ratios of MyHC isoforms. The vast majority of myofibers in both the orbital and global layers expressed more than one MyHC isoform, with up to six isoforms in single fiber segments. MyHC expression varied significantly and unpredictably along the length of single myofibers. Thus EOM myofibers represent a continuum in their histological and physiological characteristics. This continuum would facilitate fine motor control of eye position, speed, and direction of movement in all positions of gaze and with all types of eye movements-from slow vergence movements to fast saccades. To fully understand how the brain controls eye position and movements, it is critical that this significant EOM myofiber heterogeneity be integrated into hypotheses of oculomotor control.

  10. Muscle shortening velocity depends on tissue inertia and level of activation during submaximal contractions.

    Ross, Stephanie A; Wakeling, James M


    In order to perform external work, muscles must do additional internal work to deform their tissue, and in particular, to overcome the inertia due to their internal mass. However, the contribution of the internal mass within a muscle to the mechanical output of that muscle has only rarely been studied. Here, we use a dynamic, multi-element Hill-type muscle model to examine the effects of the inertial mass within muscle on its contractile performance. We find that the maximum strain-rate of muscle is slower for lower activations and larger muscle sizes. As muscle size increases, the ability of the muscle to overcome its inertial load will decrease, as muscle tension is proportional to cross-sectional area and inertial load is proportional to mass. Thus, muscles that are larger in size will have a higher inertial cost to contraction. Similarly, when muscle size and inertial load are held constant, decreasing muscle activation will increase inertial cost to contraction by reducing muscle tension. These results show that inertial loads within muscle contribute to a slowing of muscle contractile velocities (strain-rates), particularly at the submaximal activations that are typical during animal locomotion.

  11. Maximum Likelihood Blood Velocity Estimator Incorporating Properties of Flow Physics

    Schlaikjer, Malene; Jensen, Jørgen Arendt


    The aspect of correlation among the blood velocities in time and space has not received much attention in previous blood velocity estimators. The theory of fluid mechanics predicts this property of the blood flow. Additionally, most estimators based on a cross-correlation analysis are limited...... of simulated and in vivo data from the carotid artery. The estimator is meant for two-dimensional (2-D) color flow imaging. The resulting mathematical relation for the estimator consists of two terms. The first term performs a cross-correlation analysis on the signal segment in the radio frequency (RF......)-data under investigation. The flow physic properties are exploited in the second term, as the range of velocity values investigated in the cross-correlation analysis are compared to the velocity estimates in the temporal and spatial neighborhood of the signal segment under investigation. The new estimator...

  12. Detrimental effects of reloading recovery on force, shortening velocity, and power of soleus muscles from hindlimb-unloaded rats.

    Widrick, J J; Maddalozzo, G F; Hu, H; Herron, J C; Iwaniec, U T; Turner, R T


    To better understand how atrophied muscles recover from prolonged nonweight-bearing, we studied soleus muscles (in vitro at optimal length) from female rats subjected to normal weight bearing (WB), 15 days of hindlimb unloading (HU), or 15 days HU followed by 9 days of weight bearing reloading (HU-R). HU reduced peak tetanic force (P(o)), increased maximal shortening velocity (V(max)), and lowered peak power/muscle volume. Nine days of reloading failed to improve P(o), while depressing V(max) and intrinsic power below WB levels. These functional changes appeared intracellular in origin as HU-induced reductions in soleus mass, fiber cross-sectional area, and physiological cross-sectional area were partially or completely restored by reloading. We calculated that HU-induced reductions in soleus fiber length were of sufficient magnitude to overextend sarcomeres onto the descending limb of their length-tension relationship upon the resumption of WB activity. In conclusion, the force, shortening velocity, and power deficits observed after 9 days of reloading are consistent with contraction-induced damage to the soleus. HU-induced reductions in fiber length indicate that sarcomere hyperextension upon the resumption of weight-bearing activity may be an important mechanism underlying this response.

  13. Maximum velocity of self-propulsion for an active segment

    Recho, Pierre


    The motor part of a crawling eukaryotic cell can be represented schematically as an active continuum layer. The main active processes in this layer are protrusion, originating from non-equilibrium polymerization of actin fibers, contraction, induced by myosin molecular motors and attachment due to active bonding of trans-membrane proteins to a substrate. All three active mechanisms are regulated by complex signaling pathways involving chemical and mechanical feedback loops whose microscopic functioning is still poorly understood. In this situation, it is instructive to take a reverse engineering approach and study a problem of finding the spatial organization of standard active elements inside a crawling layer ensuring an optimal cost-performance trade-off. In this paper we assume that (in the range of interest) the energetic cost of self-propulsion is velocity independent and adopt, as an optimality criterion, the maximization of the overall velocity. We then choose a prototypical setting, formulate the corr...

  14. Measuring of the maximum measurable velocity for dual-frequency laser interferometer

    Zhiping Zhang; Zhaogu Cheng; Zhaoyu Qin; Jianqiang Zhu


    There is an increasing demand on the measurable velocity of laser interferometer in manufacturing technologies. The maximum measurable velocity is limited by frequency difference of laser source, optical configuration, and electronics bandwidth. An experimental setup based on free falling movement has been demonstrated to measure the maximum easurable velocity for interferometers. Measurement results show that the maximum measurable velocity is less than its theoretical value. Moreover, the effect of kinds of factors upon the measurement results is analyzed, and the results can offer a reference for industrial applications.

  15. The NFL Combine 40-Yard Dash: How Important is Maximum Velocity?

    Clark, Kenneth P; Rieger, Randall H; Bruno, Richard F; Stearne, David J


    This investigation analyzed the sprint velocity profiles for athletes who completed the 40-yard (36.6m) dash at the 2016 NFL Combine. The purpose was to evaluate the relationship between maximum velocity and sprint performance, and to compare acceleration patterns for fast and slow athletes. Using freely available online sources, data were collected for body mass and sprint performance (36.6m time with split intervals at 9.1 and 18.3m). For each athlete, split times were utilized to generate modeled curves of distance vs. time, velocity vs. time, and velocity vs. distance using a mono-exponential equation. Model parameters were used to quantify acceleration patterns as the ratio of maximum velocity to maximum acceleration (vmax / amax, or τ). Linear regression was used to evaluate the relationship between maximum velocity and sprint performance for the entire sample. Additionally, athletes were categorized into fast and slow groups based on maximum velocity, with independent t-tests and effect size statistics used to evaluate between-group differences in sprint performance and acceleration patterns. Results indicated that maximum velocity was strongly correlated with sprint performance across 9.1m, 18.3m, and 36.6m (r of 0.72, 0.83, and 0.94, respectively). However, both fast and slow groups accelerated in a similar pattern relative to maximum velocity (τ = 0.768 ± 0.068s for the fast group and τ = 0.773 ± 0.070s for the slow group). We conclude that maximum velocity is of critical importance to 36.6m time, and inclusion of more maximum velocity training may be warranted for athletes preparing for the NFL Combine.

  16. Shortening induced effects on force (re)development in pig urinary smooth muscle

    van Asselt, Els; Pel, Johan; van Mastrigt, Ron


    textabstractIntroduction: When muscle is allowed to shorten during an active contraction, the maximum force that redevelops after shortening is smaller than the isometric force at the same muscle length without prior shortening. We studied the course of force redevelopment after shortening in smooth muscle to unravel the mechanism responsible for this deactivation. Method: In a first series of measurements the shortening velocity was varied resulting in different shortening amplitudes. In a s...

  17. Modelling the maximum voluntary joint torque/angular velocity relationship in human movement.

    Yeadon, Maurice R; King, Mark A; Wilson, Cassie


    The force exerted by a muscle is a function of the activation level and the maximum (tetanic) muscle force. In "maximum" voluntary knee extensions muscle activation is lower for eccentric muscle velocities than for concentric velocities. The aim of this study was to model this "differential activation" in order to calculate the maximum voluntary knee extensor torque as a function of knee angular velocity. Torque data were collected on two subjects during maximal eccentric-concentric knee extensions using an isovelocity dynamometer with crank angular velocities ranging from 50 to 450 degrees s(-1). The theoretical tetanic torque/angular velocity relationship was modelled using a four parameter function comprising two rectangular hyperbolas while the activation/angular velocity relationship was modelled using a three parameter function that rose from submaximal activation for eccentric velocities to full activation for high concentric velocities. The product of these two functions gave a seven parameter function which was fitted to the joint torque/angular velocity data, giving unbiased root mean square differences of 1.9% and 3.3% of the maximum torques achieved. Differential activation accounts for the non-hyperbolic behaviour of the torque/angular velocity data for low concentric velocities. The maximum voluntary knee extensor torque that can be exerted may be modelled accurately as the product of functions defining the maximum torque and the maximum voluntary activation level. Failure to include differential activation considerations when modelling maximal movements will lead to errors in the estimation of joint torque in the eccentric phase and low velocity concentric phase.

  18. The Relationship Between Maximum Isometric Strength and Ball Velocity in the Tennis Serve

    Corbi, Francisco; Fuentes, Juan Pedro; Fernández-Fernández, Jaime


    Abstract The aims of this study were to analyze the relationship between maximum isometric strength levels in different upper and lower limb joints and serve velocity in competitive tennis players as well as to develop a prediction model based on this information. Twelve male competitive tennis players (mean ± SD; age: 17.2 ± 1.0 years; body height: 180.1 ± 6.2 cm; body mass: 71.9 ± 5.6 kg) were tested using maximum isometric strength levels (i.e., wrist, elbow and shoulder flexion and extension; leg and back extension; shoulder external and internal rotation). Serve velocity was measured using a radar gun. Results showed a strong positive relationship between serve velocity and shoulder internal rotation (r = 0.67; p elbow and shoulder flexion – extension, leg and back extension and shoulder external rotation (r = 0.36 – 0.53; p = 0.377 – 0.054). Bivariate and multivariate models for predicting serve velocity were developed, with shoulder flexion and internal rotation explaining 55% of the variance in serve velocity (r = 0.74; p < 0.001). The maximum isometric strength level in shoulder internal rotation was strongly related to serve velocity, and a large part of the variability in serve velocity was explained by the maximum isometric strength levels in shoulder internal rotation and shoulder flexion. PMID:28149411

  19. CD4+ T cells enhance the unloaded shortening velocity of airway smooth muscle by altering the contractile protein expression.

    Matusovsky, Oleg S; Nakada, Emily M; Kachmar, Linda; Fixman, Elizabeth D; Lauzon, Anne-Marie


    Abundant data indicate that pathogenesis in allergic airways disease is orchestrated by an aberrant T-helper 2 (Th2) inflammatory response. CD4(+) T cells have been localized to airway smooth muscle (ASM) in both human asthmatics and in rodent models of allergic airways disease, where they have been implicated in proliferative responses of ASM. Whether CD4(+) T cells also alter ASM contractility has not been addressed. We established an in vitro system to assess the ability of antigen-stimulated CD4(+) T cells to modify contractile responses of the Brown Norway rat trachealis muscle. Our data demonstrated that the unloaded velocity of shortening (Vmax) of ASM was significantly increased upon 24 h co-incubation with antigen-stimulated CD4(+) T cells, while stress did not change. Enhanced Vmax was dependent upon contact between the CD4(+) T cells and the ASM and correlated with increased levels of the fast (+)insert smooth muscle myosin heavy chain isoform. The levels of myosin light chain kinase and myosin light chain phosphorylation were also increased within the muscle. The alterations in mechanics and in the levels of contractile proteins were transient, both declining to control levels after 48 h of co-incubation. More permanent alterations in muscle phenotype might be attainable when several inflammatory cells and mediators interact together or after repeated antigenic challenges. Further studies will await new tissue culture methodologies that preserve the muscle properties over longer periods of time. In conclusion, our data suggest that inflammatory cells promote ASM hypercontractility in airway hyper-responsiveness and asthma.

  20. Maximum Velocity of a Boulder Ejected From an Impact Crater Formed on a Regolith Covered Surface

    Bart, G. D.; Melosh, H. J.


    We investigate the effect of regolith depth on boulder ejection velocity. A "boulder" refers to an apparently intact rock or rock fragment lying on a planetary surface, regardless of emplacement mechanism. Boulders appear in planetary images as positive relief features --- bright, sun-facing pixels adjacent to dark, shadowed pixels. We studied 12 lunar craters in high resolution (1~m) photographs from Lunar Orbiter III and V. Local regolith depth was measured using the method of small crater morphology. Ejection velocities of boulders were calculated assuming a ballistic trajectory to the final boulder location. A plot of regolith depth/crater diameter vs. maximum boulder ejection velocity shows that craters formed in deeper regolith (with respect to crater size) eject boulders at lower velocities. When ejection velocity (EjV) is in m/s, and regolith depth (Dr) and crater diameter (Dc) are in meters, the data fit the relation Dr / Dc = 1053 × EjVmax-2.823. To explain the data, we turn to impact cratering theory. An ejected particle will follow a streamline from its place of origin to its ejection point (the Z-model), and then follow a ballistic trajectory. Material ejected along more shallow streamlines is ejected at greater velocities. If shallow regolith covers the surface, the most shallow (greatest velocity) streamlines will travel only through the regolith. Boulders, however, must be ejected from the bedrock below the regolith. Thus, the boulder ejected with the greatest velocity originates just below the regolith, along the most shallow streamline through the bedrock. If the regolith is deeper, the most shallow streamline through the bedrock will be deeper, and the maximum velocity of an ejected boulder will be lower. Hence, the regolith depth and maximum ejection velocity of a boulder are correlated: greater boulder ejection velocities correspond to thinner regolith. We observe this correlation in the data.

  1. Estimation of the maximum contraction velocity of the urinary bladder from pressure and flow throughout micturition.

    R. van Mastrigt (Ron)


    textabstractThe contractility of the urinary bladder can be adequately described in terms of the parameters P0 (isometric pressure) and Vmax (maximum contraction velocity). In about 12% of urodynamic evaluations of patients these clinically relevant parameters can be calculated from pressure and flo

  2. Neurogenic modulation of micturition: the relation between stimulation intensity and the maximum shortening velocity of the guinea pig detrusor muscle

    J.M. Groen (Jan); R. van Mastrigt (Ron); J.L.H.R. Bosch (Ruud)


    textabstractThe course of micturition depends on bladder contractility and urethral resistance. The former is determined by geometrical, muscular and neurogenic factors. The muscular aspects of bladder contractility can be characterized by the parameters Pisv, the isovolumetric detrusor pressure, an

  3. Solar wind velocity at solar maximum: A search for latitudinal effects

    B. Bavassano


    Full Text Available Observations by Ulysses during its second out-of-ecliptic orbit have shown that near the solar activity maximum the solar wind appears as a highly variable flow at all heliolatitudes. In the present study Ulysses data from polar latitudes are compared to contemporary ACE data in the ecliptic plane to search for the presence of latitudinal effects in the large-scale structure of the solar wind velocity. The investigated period roughly covers the Sun's magnetic polarity reversal. The Ulysses-ACE comparison is performed through a multi-scale statistical analysis of the velocity fluctuations at scales from 1 to 64 days. The results indicate that, from a statistical point of view, the character of the wind velocity structure does not appear to change remarkably with latitude. It is likely that this result is characteristic of the particular phase of the solar magnetic cycle.

  4. The relationship between consistency of propulsive cycles and maximum angular velocity during wheelchair racing.

    Wang, Yong Tai; Vrongistinos, Konstantinos Dino; Xu, Dali


    The purposes of this study were to examine the consistency of wheelchair athletes' upper-limb kinematics in consecutive propulsive cycles and to investigate the relationship between the maximum angular velocities of the upper arm and forearm and the consistency of the upper-limb kinematical pattern. Eleven elite international wheelchair racers propelled their own chairs on a roller while performing maximum speeds during wheelchair propulsion. A Qualisys motion analysis system was used to film the wheelchair propulsive cycles. Six reflective markers placed on the right shoulder, elbow, wrist joints, metacarpal, wheel axis, and wheel were automatically digitized. The deviations in cycle time, upper-arm and forearm angles, and angular velocities among these propulsive cycles were analyzed. The results demonstrated that in the consecutive cycles of wheelchair propulsion the increased maximum angular velocity may lead to increased variability in the upper-limb angular kinematics. It is speculated that this increased variability may be important for the distribution of load on different upper-extremity muscles to avoid the fatigue during wheelchair racing.


    P E Alcaraz


    Full Text Available Performing sprints on a sand surface is a common training method for improving sprint-specific strength. For maximum specificity of training the athlete’s movement patterns during the training exercise should closely resemble those used when performing the sport. The aim of this study was to compare the kinematics of sprinting at maximum velocity on a dry sand surface to the kinematics of sprinting on an athletics track. Five men and five women participated in the study, and flying sprints over 30 m were recorded by video and digitized using biomechanical analysis software. We found that sprinting on a sand surface was substantially different to sprinting on an athletics track. When sprinting on sand the athletes tended to ‘sit’ during the ground contact phase of the stride. This action was characterized by a lower centre of mass, a greater forward lean in the trunk, and an incomplete extension of the hip joint at take-off. We conclude that sprinting on a dry sand surface may not be an appropriate method for training the maximum velocity phase in sprinting. Although this training method exerts a substantial overload on the athlete, as indicated by reductions in running velocity and stride length, it also induces detrimental changes to the athlete’s running technique which may transfer to competition sprinting.

  6. Effect of spaceflight on the maximal shortening velocity, morphology, and enzyme profile of fast- and slow-twitch skeletal muscle fibers in rhesus monkeys

    Fitts, R. H.; Romatowski, J. G.; De La Cruz, L.; Widrick, J. J.; Desplanches, D.


    Weightlessness has been shown to cause limb muscle wasting and a reduced peak force and power in the antigravity soleus muscle. Despite a reduced peak power, Caiozzo et al. observed an increased maximal shortening velocity in the rat soleus muscle following a 14-day space flight. The major purpose of the present investigation was to determine if weightlessness induced an elevated velocity in the antigravity slow type I fibers of the rhesus monkey (Macaca mulatta), as well as to establish a cellular mechanism for the effect. Spaceflight or models of weightlessness have been shown to increase glucose uptake, elevate muscle glycogen content, and increase fatigability of the soleus muscle. The latter appears to be in part caused by a reduced ability of the slow oxidative fibers to oxidize fats. A second goal of this study was to establish the extent to which weightlessness altered the substrate profile and glycolytic and oxidative enzyme capacity of individual slow- and fast-twitch fibers.

  7. Analysis of the Velocity Distribution in Partially-Filled Circular Pipe Employing the Principle of Maximum Entropy.

    Jiang, Yulin; Li, Bin; Chen, Jie


    The flow velocity distribution in partially-filled circular pipe was investigated in this paper. The velocity profile is different from full-filled pipe flow, since the flow is driven by gravity, not by pressure. The research findings show that the position of maximum flow is below the water surface, and varies with the water depth. In the region of near tube wall, the fluid velocity is mainly influenced by the friction of the wall and the pipe bottom slope, and the variation of velocity is similar to full-filled pipe. But near the free water surface, the velocity distribution is mainly affected by the contractive tube wall and the secondary flow, and the variation of the velocity is relatively small. Literature retrieval results show relatively less research has been shown on the practical expression to describe the velocity distribution of partially-filled circular pipe. An expression of two-dimensional (2D) velocity distribution in partially-filled circular pipe flow was derived based on the principle of maximum entropy (POME). Different entropies were compared according to fluid knowledge, and non-extensive entropy was chosen. A new cumulative distribution function (CDF) of partially-filled circular pipe velocity in terms of flow depth was hypothesized. Combined with the CDF hypothesis, the 2D velocity distribution was derived, and the position of maximum velocity distribution was analyzed. The experimental results show that the estimated velocity values based on the principle of maximum Tsallis wavelet entropy are in good agreement with measured values.

  8. Scaling of maximum probability density functions of velocity and temperature increments in turbulent systems

    Huang, Y X; Zhou, Q; Qiu, X; Shang, X D; Lu, Z M; Liu, and Y L


    In this paper, we introduce a new way to estimate the scaling parameter of a self-similar process by considering the maximum probability density function (pdf) of tis increments. We prove this for $H$-self-similar processes in general and experimentally investigate it for turbulent velocity and temperature increments. We consider turbulent velocity database from an experimental homogeneous and nearly isotropic turbulent channel flow, and temperature data set obtained near the sidewall of a Rayleigh-B\\'{e}nard convection cell, where the turbulent flow is driven by buoyancy. For the former database, it is found that the maximum value of increment pdf $p_{\\max}(\\tau)$ is in a good agreement with lognormal distribution. We also obtain a scaling exponent $\\alpha\\simeq 0.37$, which is consistent with the scaling exponent for the first-order structure function reported in other studies. For the latter one, we obtain a scaling exponent $\\alpha_{\\theta}\\simeq0.33$. This index value is consistent with the Kolmogorov-Ob...

  9. Frequency-dependent effects of phenytoin on the maximum upstroke velocity of action potentials in guinea-pig papillary muscles.

    Kojima, M; Ichiyama, M; Ban, T


    Phenytoin, at 50 to 200 micrograms reduced the maximum upstroke velocity of action potentials (Vmax) with increases in frequency from 0.25 to 5 Hz and in the external potassium concentration [( K+]0) from 2.7 to 8.1 mM. The drug-induced shortening of action potential duration was evident at 0.25 to 2 Hz but little at 3 to 5 Hz. Time courses of recovery of Vmax was studied by applying premature responses between the conditioning responses at 1 Hz both in control and in drug-treated preparations. Concerning the time courses of the difference between the Vmax values before and after drug treatments at the same diastolic interval, with increases in drug concentrations the intercepts at APD90 were increased but the time constants were not changed or slightly decreased in 8.1 to 5.4 mM [K+]0, whereas they were increased in 2.7 mM [K+]0. To understand the kinetic behavior of this drug on sodium channels, rate constants for the interaction of phenytoin with three states of channels in terms of Hondeghem-Katzung model were estimated from the above experiments of Vmax. The model most consistent with the present experiments was that with an affinity for inactivated channels 20 times greater than that for resting channels and with a minor affinity for open channels. Phenytoin produced a delay in the time course of recovery of overshoot and action potential duration at 0 mV (APD0), suggesting an additional inhibition of the slow channel by this drug.

  10. Enhancement of shortening velocity, power, and acto-myosin crossbridge (CB) kinetics following long-term treatment with propionyl-L-carnitine, coenzyme Q10, and omega-3 fatty acids in BIO TO-2 cardiomyopathic Syrian hamsters papillary muscle.

    Vargiu, Romina; Littarru, Gian Paolo; Fraschini, Matteo; Perinu, Anna; Tiano, Luca; Capra, Alessandro; Mancinelli, Rino


    Impaired functions of myocardial muscle cells in human and animals, is a primary defect associated with idiopathic dilated cardiomyopathy (DCM). The pathophysiological mechanisms implicated in the DCM are yet to be clarified and an effective therapy is still not available. The BIO TO-2 cardiomyopathic Syrian Hamsters (CMSHs) represent an animal model of idiopathic DCM. The aim of this study was to investigate the effect of long-term treatment (2 months) with propionyl-L-carnitine (PLC), coenzyme Q(10), omega-3 fatty acids and a combination of these three agents (formulation HS12607) on mechanical properties and acto-myosin crossbridges (CBs) kinetics of left ventricular (LV) papillary muscle from control and treated 10 month old BIO TO-2 CMSHs. Isometric and isotonic contractile properties of isolated papillary muscle from control and treated CMSHs were investigated, and acto-myosin CB number, force and kinetics were calculated using Huxley's equations. Mechanical parameter values were higher in treated than in control hamsters, particularly when substances were administered together in a coformulation (HS12607). Compared to control, HS12607-treated papillary muscles showed a significant increase of maximum peak isometric tension (P(o)) (30.06 +/- 4.91 vs. 19.74 +/- 5.00 mN/mm(2)), maximum extent of muscle shortening (0.13 +/- 0.03 vs. 0.07 +/- 0.02 L/L(max)), maximum unloaded shortening velocity (1.18 +/- 0.24 vs. 0.53 +/- 0.13 L/L(max) s(-1)) and maximum peak of power output (5.52 +/- 1.61 vs. 1.58 +/- 0.83). The curvature of the hyperbolic force-velocity relationships did not differ between control and treated hamsters. When compared to controls, acto-myosin CB number increased in treated hamsters [(6.67 +/- 1.91) 10(10)/mm(2) vs. (3.55 +/- 2.08) 10(10)/mm(2)], whereas the unitary force of single CB was similar in control and treated animals. The peak value of the rate constant for CB attachment (f(1)) and detachment (g(2)) was higher in treated animals when

  11. Study on Droplet Size and Velocity Distributions of a Pressure Swirl Atomizer Based on the Maximum Entropy Formalism

    Kai Yan


    Full Text Available A predictive model for droplet size and velocity distributions of a pressure swirl atomizer has been proposed based on the maximum entropy formalism (MEF. The constraint conditions of the MEF model include the conservation laws of mass, momentum, and energy. The effects of liquid swirling strength, Weber number, gas-to-liquid axial velocity ratio and gas-to-liquid density ratio on the droplet size and velocity distributions of a pressure swirl atomizer are investigated. Results show that model based on maximum entropy formalism works well to predict droplet size and velocity distributions under different spray conditions. Liquid swirling strength, Weber number, gas-to-liquid axial velocity ratio and gas-to-liquid density ratio have different effects on droplet size and velocity distributions of a pressure swirl atomizer.

  12. In vivo human cardiac shortening and lengthening velocity is region dependent and not coupled with heart rate: 'longitudinal' strain rate markedly underestimates apical contribution.

    Stöhr, Eric J; Stembridge, Mike; Esformes, Joseph I


    What is the central question of this study? Regulation of cardiac function is typically achieved by changes in heart rate (HR) and cardiac shortening velocity (strain rate; SR), but their interdependence in vivo remains poorly understood. What is the main finding and its importance? Using resistance exercise to increase heart rate and arterial resistance physiologically in humans and measuring regional cardiac SR (at the base and apex), we found that HR and SR were not strictly coupled because SR at the base and apex responded differently, despite the same HR. Importantly, our data show that the region-averaged 'longitudinal' SR, which is currently popular in the clinical setting, markedly underestimates the contribution of the apex. The fundamental importance of cardiac shortening and lengthening velocity (i.e. strain rate; SR) has been demonstrated in vitro. Currently, the interdependence between in vivo SR and HR is poorly understood because studies have typically assessed region-averaged 'longitudinal' strain rate, which is likely to underestimate the apical contribution, and have used non-physiological interventions that may also have been influenced by multicollinearity caused by concomitant reductions in arterial resistance. Resistance exercise acutely raises HR, blood pressure and arterial resistance and transiently disassociates these cardiovascular factors following exercise. Therefore, we measured SR, HR, blood pressure and arterial resistance in nine healthy men (aged 20 ± 1 years) immediately before, during and after double-leg-press exercise at 30 and 60% of maximal strength. Resistance exercise caused a disproportionate SR response at the left ventricular base and apex (interaction effect, P < 0.05). Consequently, associations between HR and regional peak SR were inconsistent and mostly very weak (r(2)  = 0.0004-0.24). Likewise, the areas under the curve for systolic and diastolic SR and their relationship with systolic and diastolic duration

  13. Optimal Velocity to Achieve Maximum Power Output – Bench Press for Trained Footballers

    Richard Billich


    Full Text Available Optimal Velocity to Achieve Maximum Power Output – Bench Press for Trained Footballers In today’s world of strength training there are many myths surrounding effective exercising with the least possible negative effect on one’s health. In this experiment we focus on the finding of a relationship between maximum output, used load and the velocity with which the exercise is performed. The main objective is to find the optimal speed of the exercise motion which would allow us to reach the maximum mechanic muscle output during a bench press exercise. This information could be beneficial to sporting coaches and recreational sportsmen alike in helping them improve the effectiveness of fast strength training. Fifteen football players of the FK Třinec football club participated in the experiment. The measurements were made with the use of 3D cinematic and dynamic analysis, both experimental methods. The research subjects participated in a strength test, in which the mechanic muscle output of 0, 10, 30, 50, 70, 90% and one repetition maximum (1RM was measured. The acquired result values and other required data were modified using Qualisys Track Manager and Visual 3D software (C-motion, Rockville, MD, USA. During the bench press exercise the maximum mechanic muscle output of the set of research subjects was reached at 75% of maximum exercise motion velocity. Optimální rychlost pohybu pro dosažení maxima výstupního výkonu – bench press u trénovaných fotbalistů Dnešní svět silového tréninku přináší řadu mýtů o tom, jak cvičit efektivně a zároveň s co nejmenším negativním vlivem na zdraví člověka. V tomto experimentu se zabýváme nalezením vztahu mezi maximálním výkonem, použitou zátěží a rychlostí. Hlavním úkolem je nalezení optimální rychlosti pohybu pro dosažení maximálního mechanického svalového výkonu při cvičení bench press, což pomůže nejenom trenérům, ale i rekreačním sportovc

  14. Mechanisms of quinidine-induced depression of maximum upstroke velocity in ovine cardiac Purkinje fibers.

    Weld, F M; Coromilas, J; Rottman, J N; Bigger, J T


    A major advance in understanding how quinidine depresses maximum upstroke velocity (Vmax) is the Hondeghem-Katzung mathematical model which incorporates voltage-independent rate constants for binding to and unbinding from resting, open, and inactive Na channels, and a voltage shift of -40 mV for the Hodgkin-Huxley h-kinetics of quinidine-associated Na channels. Using a double microelectrode voltage clamp technique to control transmembrane voltage and apply conditioning pulses, we found that quinidine blockade increased as transmembrane voltage became more positive in the range -60 to +40 mV, and that the rate of quinidine dissociation increased as transmembrane voltage became more negative in the range -60 to -140 mV. The relationship of Vmax to transmembrane voltage obtained at drive cycles from 500 msec to 20 seconds conformed to the model modified to include voltage-dependent rate constants without the postulated -40-mV shift for quinidine-associated channels. Thus binding of quinidine to inactive Na channels and unbinding from resting channels are both voltage-dependent and can explain frequency and voltage dependent actions of quinidine on Vmax without any voltage shift for quinidine-associated channels.

  15. Complex myograph allows the examination of complex muscle contractions for the assessment of muscle force, shortening, velocity, and work in vivo

    Ruhschulte Hainer


    Full Text Available Abstract Background The devices used for in vivo examination of muscle contractions assess only pure force contractions and the so-called isokinetic contractions. In isokinetic experiments, the extremity and its muscle are artificially moved with constant velocity by the measuring device, while a tetanic contraction is induced in the muscle, either by electrical stimulation or by maximal voluntary activation. With these systems, experiments cannot be performed at pre-defined, constant muscle length, single contractions cannot be evaluated individually and the separate examination of the isometric and the isotonic components of single contractions is not possible. Methods The myograph presented in our study has two newly developed technical units, i.e. a. a counterforce unit which can load the muscle with an adjustable, but constant force and b. a length-adjusting unit which allows for both the stretching and the contraction length to be infinitely adjustable independently of one another. The two units support the examination of complex types of contraction and store the counterforce and length-adjusting settings, so that these conditions may be accurately reapplied in later sessions. Results The measurement examples presented show that the muscle can be brought to every possible pre-stretching length and that single isotonic or complex isometric-isotonic contractions may be performed at every length. The applied forces act during different phases of contraction, resulting into different pre- and after-loads that can be kept constant – uninfluenced by the contraction. Maximal values for force, shortening, velocity and work may be obtained for individual muscles. This offers the possibility to obtain information on the muscle status and to monitor its changes under non-invasive measurement conditions. Conclusion With the Complex Myograph, the whole spectrum of a muscle's mechanical characteristics may be assessed.

  16. A new maximum likelihood blood velocity estimator incorporating spatial and temporal correlation

    Schlaikjer, Malene; Jensen, Jørgen Arendt


    The blood flow in the human cardiovascular system obeys the laws of fluid mechanics. Investigation of the flow properties reveals that a correlation exists between the velocity in time and space. The possible changes in velocity are limited, since the blood velocity has a continuous profile in time...... of the observations gives a probability measure of the correlation between the velocities. Both the MLE and the STC-MLE have been evaluated on simulated and in-vivo RF-data obtained from the carotid artery. Using the MLE 4.1% of the estimates deviate significantly from the true velocities, when the performance...

  17. The mechanics of mouse skeletal muscle when shortening during relaxation.

    Barclay, C J; Lichtwark, G A


    The dynamic properties of relaxing skeletal muscle have not been well characterised but are important for understanding muscle function during terrestrial locomotion, during which a considerable fraction of muscle work output can be produced during relaxation. The purpose of this study was to characterise the force-velocity properties of mouse skeletal muscle during relaxation. Experiments were performed in vitro (21 degrees C) using bundles of fibres from mouse soleus and EDL muscles. Isovelocity shortening was applied to muscles during relaxation following short tetanic contractions. Using data from different contractions with different shortening velocities, curves relating force output to shortening velocity were constructed at intervals during relaxation. The velocity component included contributions from shortening of both series elastic component (SEC) and contractile component (CC) because force output was not constant. Early in relaxation force-velocity relationships were linear but became progressively more curved as relaxation progressed. Force-velocity curves late in relaxation had the same curvature as those for the CC in fully activated muscles but V(max) was reduced to approximately 50% of the value in fully activated muscles. These results were the same for slow- and fast-twitch muscles and for relaxation following maximal tetani and brief, sub-maximal tetani. The measured series elastic compliance was used to partition shortening velocity between SEC and CC. The curvature of the CC force-velocity relationship was constant during relaxation. The SEC accounted for most of the shortening and work output during relaxation and its power output during relaxation exceeded the maximum CC power output. It is proposed that unloading the CC, without any change in its overall length, accelerated cross-bridge detachment when shortening was applied during relaxation.

  18. The Silicon and Calcium High-Velocity Features in Type Ia Supernovae from Early to Maximum Phases

    Zhao, Xulin; Maeda, Keiichi; Sai, Hanna; Zhang, Tianmeng; Zhang, Jujia; Huang, Fang; Rui, Liming; Zhou, Qi; Mo, Jun


    The high-velocity features (HVFs) in optical spectra of type Ia supernovae (SNe Ia) are examined with a large sample including very early-time spectra (e.g., t < -7 days). Multiple Gaussian fits are applied to examine the HVFs and their evolutions, using constraints on expansion velocities for the same species (i.e., SiII 5972 and SiII 6355). We find that strong HVFs tend to appear in SNe Ia with smaller decline rates (e.g., dm15(B)<1.4 mag), clarifying that the finding by Childress et al. (2014) for the Ca-HVFs in near-maximum-light spectra applies both to the Si-HVFs and Ca-HVFs in the earlier phase. The Si-HVFs seem to be more common in fast-expanding SNe Ia, which is different from the earlier result that the Ca-HVFs are associated with SNe Ia having slower SiII 6355 velocities at maximum light (i.e., Vsi). This difference can be due to that the HVFs in fast-expanding SNe Ia usually disappear more rapidly and are easily blended with the photospheric components when approaching the maximum light. Mor...

  19. Climate change velocity since the Last Glacial Maximum and its importance for patterns of species richness and range size

    Sandel, Brody Steven; Arge, Lars Allan; Svenning, J.-C.

    Contemporary patterns of species distributions are influenced by both current and historical conditions. Historically unstable climates can lead to reductions in species richness, when species go extinct because they cannot track climate changes, when dispersal limitation causes species to fail...... to fully occupy suitable habitat, or when local diversification rates are depressed by local population extinctions and changing selective regimes. Locations with long-term climate instability should therefore show reduced species richness with small-ranged species particularly missing from the community....... We used a novel measure of climate stability, climate change velocity, which combines information on temporal and spatial gradients in climate to describe the rate at which a particular climate condition is moving over the surface of the Earth. Climate change velocity since the Last Glacial Maximum...

  20. Effects of three types of resisted sprint training devices on the kinematics of sprinting at maximum velocity.

    Alcaraz, Pedro E; Palao, José M; Elvira, José L L; Linthorne, Nicholas P


    Resisted sprint running is a common training method for improving sprint-specific strength. For maximum specificity of training, the athlete's movement patterns during the training exercise should closely resemble those used when performing the sport. The purpose of this study was to compare the kinematics of sprinting at maximum velocity to the kinematics of sprinting when using three of types of resisted sprint training devices (sled, parachute, and weight belt). Eleven men and 7 women participated in the study. Flying sprints greater than 30 m were recorded by video and digitized with the use of biomechanical analysis software. The test conditions were compared using a 2-way analysis of variance with a post-hoc Tukey test of honestly significant differences. We found that the 3 types of resisted sprint training devices are appropriate devices for training the maximum velocity phase in sprinting. These devices exerted a substantial overload on the athlete, as indicated by reductions in stride length and running velocity, but induced only minor changes in the athlete's running technique. When training with resisted sprint training devices, the coach should use a high resistance so that the athlete experiences a large training stimulus, but not so high that the device induces substantial changes in sprinting technique. We recommend using a video overlay system to visually compare the movement patterns of the athlete in unloaded sprinting to sprinting with the training device. In particular, the coach should look for changes in the athlete's forward lean and changes in the angles of the support leg during the ground contact phase of the stride.

  1. Estimations of One Repetition Maximum and Isometric Peak Torque in Knee Extension Based on the Relationship Between Force and Velocity.

    Sugiura, Yoshito; Hatanaka, Yasuhiko; Arai, Tomoaki; Sakurai, Hiroaki; Kanada, Yoshikiyo


    We aimed to investigate whether a linear regression formula based on the relationship between joint torque and angular velocity measured using a high-speed video camera and image measurement software is effective for estimating 1 repetition maximum (1RM) and isometric peak torque in knee extension. Subjects comprised 20 healthy men (mean ± SD; age, 27.4 ± 4.9 years; height, 170.3 ± 4.4 cm; and body weight, 66.1 ± 10.9 kg). The exercise load ranged from 40% to 150% 1RM. Peak angular velocity (PAV) and peak torque were used to estimate 1RM and isometric peak torque. To elucidate the relationship between force and velocity in knee extension, the relationship between the relative proportion of 1RM (% 1RM) and PAV was examined using simple regression analysis. The concordance rate between the estimated value and actual measurement of 1RM and isometric peak torque was examined using intraclass correlation coefficients (ICCs). Reliability of the regression line of PAV and % 1RM was 0.95. The concordance rate between the actual measurement and estimated value of 1RM resulted in an ICC(2,1) of 0.93 and that of isometric peak torque had an ICC(2,1) of 0.87 and 0.86 for 6 and 3 levels of load, respectively. Our method for estimating 1RM was effective for decreasing the measurement time and reducing patients' burden. Additionally, isometric peak torque can be estimated using 3 levels of load, as we obtained the same results as those reported previously. We plan to expand the range of subjects and examine the generalizability of our results.

  2. Calibration of the maximum carboxylation velocity (vcmax) for the Caatinga for use in dynamic global vegetation models (DGVMs)

    Rezende, L. C.; Arenque, B.; von Randow, C.; Moura, M. S.; Aidar, S. D.; Buckeridge, M. S.; Menezes, R.; Souza, L. S.; Ometto, J. P.


    The Caatinga biome in the semi-arid region of northeastern Brazil is extremely important due to its biodiversity and endemism. This biome, which is under high anthropogenic influences, presents high levels of environmental degradation, land use being among the main causes of such degradation. The simulations of land cover and the vegetation dynamic under different climate scenarios are important features for prediction of environmental risks and determination of sustainable pathways for the planet in the future. Modeling of the vegetation can be performed by use of dynamic global vegetation models (DGVMs). The DGVMs simulate the surface processes (e.g. transfer of energy, water, CO2 and momentum); plant physiology (e.g. photosynthesis, stomatal conductance) phenology; gross and net primary productivity, respiration, plant species classified by functional traits; competition for light, water and nutrients, soil characteristics and processes (e.g. nutrients, heterotrophic respiration). Currently, most of the parameters used in DGVMs are static pre-defined values, and the lack of observational information to aid choosing the most adequate values for these parameters is particularly critical for the semi-arid regions in the world. Through historical meteorological data and measurements of carbon assimilation we aim to calibrate the maximum carboxylation velocity (Vcmax), for the native species Poincianella microphylla, abundant in the Caatinga region. The field data (collected at Lat: 90 2' S, Lon: 40019' W) displayed two contrasting meteorological conditions, with precipitations of 16 mm and 104 mm prior to the sampling campaigns (April 9-13, 2012 and February 4-8, 2013; respectively). Calibration (obtaining values of Vcmax more suitable for vegetation of Caatinga) has been performed through an algorithm of pattern recognition: Classification And Regression Tree (CART) and calculation of the vapor pressure deficit (VPD), which was used as attribute for discrimination

  3. A linear description of shortening induced changes in isometric length-force characteristics of rat muscle

    Meijer, K; Grootenboer, H.J.; Koopman, H.F.J.M.; Huijing, P.A.


    Active muscle shortening reduces the isometric force potential of muscle. This observation indicates that the isometric length-force characteristics are altered during muscle shortening. Post-shortening decrease in isometric force depends on starting length, shortening amplitude and shortening velocity. In the present study, post-shortening decrease in isometric force was determined after isokinetic contractions with various shortening amplitudes initiated from different lengths of rat medial...

  4. A linear description of shortening induced changes in isometric length-force characteristics of rat muscle

    Meijer, K.; Grootenboer, H.J.; Koopman, H.F.J.M.; Huijing, P.A.


    Active muscle shortening reduces the isometric force potential of muscle. This observation indicates that the isometric length-force characteristics are altered during muscle shortening. Post-shortening decrease in isometric force depends on starting length, shortening amplitude and shortening veloc

  5. The curve shortening problem

    Chou, Kai-Seng


    Although research in curve shortening flow has been very active for nearly 20 years, the results of those efforts have remained scattered throughout the literature. For the first time, The Curve Shortening Problem collects and illuminates those results in a comprehensive, rigorous, and self-contained account of the fundamental results.The authors present a complete treatment of the Gage-Hamilton theorem, a clear, detailed exposition of Grayson''s convexity theorem, a systematic discussion of invariant solutions, applications to the existence of simple closed geodesics on a surface, and a new, almost convexity theorem for the generalized curve shortening problem.Many questions regarding curve shortening remain outstanding. With its careful exposition and complete guide to the literature, The Curve Shortening Problem provides not only an outstanding starting point for graduate students and new investigations, but a superb reference that presents intriguing new results for those already active in the field.

  6. Active shortening protects against stretch-induced force deficits in human skeletal muscle.

    Saripalli, Anjali L; Sugg, Kristoffer B; Mendias, Christopher L; Brooks, Susan V; Claflin, Dennis R


    Skeletal muscle contraction results from molecular interactions of myosin "crossbridges" with adjacent actin filament binding sites. The binding of myosin to actin can be "weak" or "strong", and only strong binding states contribute to force production. During active shortening, the number of strongly-bound crossbridges declines with increasing shortening velocity. Forcibly stretching a muscle that is actively shortening at high velocity results in no apparent negative consequences whereas stretch of an isometrically (fixed-length) contracting muscle causes ultrastructural damage and a decline in force-generating capability. Our working hypothesis is that stretch-induced damage is uniquely attributable to the population of crossbridges that are strongly-bound. We tested the hypothesis that stretch-induced force deficits decline as the prevailing shortening velocity is increased. Experiments were performed on permeabilized segments of individual skeletal muscle fibers obtained from human subjects. Fibers were maximally activated and either allowed to generate maximum isometric force (Fo), or to shorten at velocities that resulted in force maintenance of ≈50% Fo or ≈2% Fo. For each test condition, a rapid stretch equivalent to 0.1 x optimal fiber length was applied. Relative to pre-stretch Fo, force deficits resulting from stretches applied during force maintenance of 100%, ≈50%, and ≈2% Fo were 23.2 ± 8.6%, 7.8 ± 4.2% and 0.3 ± 3.3%, respectively (mean ± SD, n=20). We conclude that stretch-induced damage declines with increasing shortening velocity, consistent with the working hypothesis that the fraction of strongly-bound crossbridges is a causative factor in the susceptibility of skeletal muscle to stretch-induced damage.

  7. Determination of maximum aerobic velocity by a five minute test with reference to running world records. A theoretical approach.

    Chamoux, A; Berthon, P; Laubignat, J F


    Field measurement of the maximal aerobic velocity (MAV) is closely linked to effort-duration then to the used protocol. We construct the relationship between running speed and running-duration logarithm from running world records. It appears a noteworthy point at 4.97 minutes, to be suggested as MAV duration point. By agreement, MAV could be measured on field by a five minute test whatever the sport may be.

  8. Dependency of the force-velocity relationships on Mg ATP in different types of muscle fibers from Xenopus laevis.

    Stienen, G J; Laarse, W. J. van der; Elzinga, G.


    MgATP binding to the actomyosin complex is followed by the dissociation of actin and myosin. The rate of this dissociation process was determined from the relationship between the maximum velocity of shortening and the MgATP concentration. It is shown here that the overall dissociation rate is rather similar in different types of muscle fibers. The relation between MgATP concentration and the maximum shortening velocity was investigated in fast and slow fibers and bundles of myofibrils of the...

  9. Probability distributions of bed load particle velocities, accelerations, hop distances, and travel times informed by Jaynes's principle of maximum entropy

    Furbish, David J.; Schmeeckle, Mark; Schumer, Rina; Fathel, Siobhan L.


    We describe the most likely forms of the probability distributions of bed load particle velocities, accelerations, hop distances, and travel times, in a manner that formally appeals to inferential statistics while honoring mechanical and kinematic constraints imposed by equilibrium transport conditions. The analysis is based on E. Jaynes's elaboration of the implications of the similarity between the Gibbs entropy in statistical mechanics and the Shannon entropy in information theory. By maximizing the information entropy of a distribution subject to known constraints on its moments, our choice of the form of the distribution is unbiased. The analysis suggests that particle velocities and travel times are exponentially distributed and that particle accelerations follow a Laplace distribution with zero mean. Particle hop distances, viewed alone, ought to be distributed exponentially. However, the covariance between hop distances and travel times precludes this result. Instead, the covariance structure suggests that hop distances follow a Weibull distribution. These distributions are consistent with high-resolution measurements obtained from high-speed imaging of bed load particle motions. The analysis brings us closer to choosing distributions based on our mechanical insight.

  10. Effects of errors in velocity tilt on maximum longitudinal compression during neutralized drift compression of intense beam pulses: I. general description

    Kaganovich, Igor D., E-mail: [Plasma Physics Laboratory, Princeton University, Princeton, NJ 08543 (United States); Massidda, Scott; Startsev, Edward A.; Davidson, Ronald C. [Plasma Physics Laboratory, Princeton University, Princeton, NJ 08543 (United States); Vay, Jean-Luc [Lawrence Berkeley National Laboratory, 1 Cyclotron Road, Berkeley, CA 94720 (United States); Friedman, Alex [Lawrence Livermore National Laboratory, 7000 East Avenue, Livermore, CA 94550 (United States)


    Neutralized drift compression offers an effective means for particle beam pulse compression and current amplification. In neutralized drift compression, a linear longitudinal velocity tilt (head-to-tail gradient) is applied to the non-relativistic beam pulse, so that the beam pulse compresses as it drifts in the focusing section. The beam current can increase by more than a factor of 100 in the longitudinal direction. We have performed an analytical study of how errors in the velocity tilt acquired by the beam in the induction bunching module limit the maximum longitudinal compression. It is found that the compression ratio is determined by the relative errors in the velocity tilt. That is, one-percent errors may limit the compression to a factor of one hundred. However, a part of the beam pulse where the errors are small may compress to much higher values, which are determined by the initial thermal spread of the beam pulse. It is also shown that sharp jumps in the compressed current density profile can be produced due to overlaying of different parts of the pulse near the focal plane. Examples of slowly varying and rapidly varying errors compared to the beam pulse duration are studied. For beam velocity errors given by a cubic function, the compression ratio can be described analytically. In this limit, a significant portion of the beam pulse is located in the broad wings of the pulse and is poorly compressed. The central part of the compressed pulse is determined by the thermal spread. The scaling law for maximum compression ratio is derived. In addition to a smooth variation in the velocity tilt, fast-changing errors during the pulse may appear in the induction bunching module if the voltage pulse is formed by several pulsed elements. Different parts of the pulse compress nearly simultaneously at the target and the compressed profile may have many peaks. The maximum compression is a function of both thermal spread and the velocity errors. The effects of the

  11. Influence of the Metal Volume Fraction on the maximum deflection and impact load of GLARE plates subjected to low velocity impact

    Bikakis, GSE; Savaidis, A.; Zalimidis, P.; Tsitos, S.


    Fiber-metal laminates are hybrid composite materials, consisting of alternating metal layers bonded to fiber-reinforced prepreg layers. GLARE (GLAss REinforced) belongs to this new family of materials. GLARE is the most successful fiber-metal laminate up to now and is currently being used for the construction of primary aerospace structures, such as the fuselage of the Airbus A380 air plane. Impact properties are very important in aerospace structures, since impact damage is caused by various sources, such as maintenance damage from dropped tools, collision between service cars or cargo and the structure, bird strikes and hail. The principal objective of this article is to evaluate the influence of the Metal Volume Fraction (MVF) on the low velocity impact response of GLARE fiber-metal laminates. Previously published differential equations of motion are employed for this purpose. The low velocity impact behavior of various circular GLARE plates is predicted and characteristic values of impact variables, which represent the impact phenomenon, are evaluated versus the corresponding MVF of the examined GLARE material grades. The considered GLARE plates are subjected to low velocity impact under identical impact conditions. A strong effect of the MVF on the maximum impact load and a significant effect on the maximum plate deflection of GLARE plates has been found.

  12. Handgrip strength, quadriceps muscle power, and optimal shortening velocity roles in maintaining functional abilities in older adults living in a long-term care home: a 1-year follow-up study

    Kozicka I


    Full Text Available Izabela Kozicka, Tomasz Kostka Department of Geriatrics, Medical University of Lodz, Lodz, Poland Purpose: To assess the relative role of handgrip strength (HGS, quadriceps muscle power (Pmax, and optimal shortening velocity (υopt in maintaining functional abilities (FAs in older adults living in a long-term care home over a 1-year follow-up. Subjects and methods: Forty-one inactive older institutionalized adults aged 69.8±9.0 years participated in this study. HGS, Pmax, υopt, cognitive function using the Mini-Mental State Examination, depressive symptoms using the Geriatric Depression Scale, nutritional status using the Mini Nutritional Assessment (MNA, and physical activity (PA using the Seven-Day Physical Activity Recall Questionnaire were assessed at baseline and at 1-year follow-up. FAs were assessed with activities of daily living (ADL, instrumental ADL, and Timed Up & Go test. Results: Both at baseline and at follow-up, FAs were related to age, HGS, Pmax/kg, υopt, MNA, and PA. These associations were generally similar in both sexes. As revealed in multiple regression analysis, υopt was the strongest predictor of FA, followed by Pmax/kg, PA, and MNA. FA deteriorated after 1 year as measured by ADL and Timed Up & Go test. Pmax and υopt, but not HGS, also decreased significantly after 1 year. Nevertheless, 1-year changes in FAs were not related to changes in HGS, Pmax, υopt, or PA. Conclusion: The 1-year period of physical inactivity among older institutionalized adults was found to have a negative effect on their FAs, Pmax, and υopt. The present study demonstrates that Pmax and, especially, υopt correlated with FAs of older adults more than HGS, both at baseline and at follow-up. Despite this, 1-year natural fluctuations of PA, Pmax, and υopt are not significant enough to influence FAs in inactive institutionalized older adults. Keywords: aging, handgrip strength, institutionalization, functional status, physical activity

  13. The effect of shortening history on isometric and dynamic muscle function.

    McDaniel, John; Elmer, Steven J; Martin, James C


    Despite numerous reports on isometric force depression, few reports have quantified force depression during active muscle shortening (dynamic force depression). The purpose of this investigation was to determine the influence of shortening history on isometric force following active shortening, force during isokinetic shortening, and velocity during isotonic shortening. The soleus muscles of four cats were subjected to a series of isokinetic contractions at three shortening velocities and isotonic contractions under three loads. Muscle excursions initiated from three different muscle lengths but terminated at a constant length. Isometric force produced subsequent to active shortening, and force or shortening velocity produced at a specific muscle length during shortening, were compared across all three conditions. Results indicated that shortening history altered isometric force by up to 5%, force during isokinetic shortening up to 30% and shortening velocity during isotonic contractions by up to 63%. Furthermore, there was a load by excursion interaction during isotonic contractions such that excursion had the most influence on shortening velocity when the loads were the greatest. There was not a velocity by excursion interaction during isokinetic contractions. Isokinetic and isotonic power-velocity relationships displayed a downward shift in power as excursions increased. Thus, to discuss force depression based on differences in isometric force subsequent to active shortening may underestimate its importance during dynamic contractions. The presence of dynamic force depression should be realized in sport performance, motor control modeling and when controlling paralyzed limbs through artificial stimulation.

  14. Influence of nonlinearity of the phonon dispersion relation on wave velocities in the four-moment maximum entropy phonon hydrodynamics

    Larecki, Wieslaw; Banach, Zbigniew


    This paper analyzes the propagation of the waves of weak discontinuity in a phonon gas described by the four-moment maximum entropy phonon hydrodynamics involving a nonlinear isotropic phonon dispersion relation. For the considered hyperbolic equations of phonon gas hydrodynamics, the eigenvalue problem is analyzed and the condition of genuine nonlinearity is discussed. The speed of the wave front propagating into the region in thermal equilibrium is first determined in terms of the integral formula dependent on the phonon dispersion relation and subsequently explicitly calculated for the Dubey dispersion-relation model: |k|=ωc-1(1+bω2). The specification of the parameters c and b for sodium fluoride (NaF) and semimetallic bismuth (Bi) then makes it possible to compare the calculated dependence of the wave-front speed on the sample’s temperature with the empirical relations of Coleman and Newman (1988) describing for NaF and Bi the variation of the second-sound speed with temperature. It is demonstrated that the calculated temperature dependence of the wave-front speed resembles the empirical relation and that the parameters c and b obtained from fitting respectively the empirical relation and the original material parameters of Dubey (1973) are of the same order of magnitude, the difference being in the values of the numerical factors. It is also shown that the calculated temperature dependence is in good agreement with the predictions of Hardy and Jaswal’s theory (Hardy and Jaswal, 1971) on second-sound propagation. This suggests that the nonlinearity of a phonon dispersion relation should be taken into account in the theories aiming at the description of the wave-type phonon heat transport and that the Dubey nonlinear isotropic dispersion-relation model can be very useful for this purpose.

  15. Shortening induced effects on force (re)development in pig urinary smooth muscle

    E. van Asselt (Els); J.J.M. Pel (Johan); R. van Mastrigt (Ron)


    textabstractIntroduction: When muscle is allowed to shorten during an active contraction, the maximum force that redevelops after shortening is smaller than the isometric force at the same muscle length without prior shortening. We studied the course of force redevelopment after shortening in smooth

  16. Crustal seismicity and the earthquake catalog maximum moment magnitudes (Mcmax) in stable continental regions (SCRs): correlation with the seismic velocity of the lithosphere

    Mooney, Walter D.; Ritsema, Jeroen; Hwang, Yong Keun


    A joint analysis of global seismicity and seismic tomography indicates that the seismic potential of continental intraplate regions is correlated with the seismic properties of the lithosphere. Archean and Early Proterozoic cratons with cold, stable continental lithospheric roots have fewer crustal earthquakes and a lower maximum earthquake catalog moment magnitude (Mcmax). The geographic distribution of thick lithospheric roots is inferred from the global seismic model S40RTS that displays shear-velocity perturbations (δVS) relative to the Preliminary Reference Earth Model (PREM). We compare δVS at a depth of 175 km with the locations and moment magnitudes (Mw) of intraplate earthquakes in the crust (Schulte and Mooney, 2005). Many intraplate earthquakes concentrate around the pronounced lateral gradients in lithospheric thickness that surround the cratons and few earthquakes occur within cratonic interiors. Globally, 27% of stable continental lithosphere is underlain by δVS≥3.0%, yet only 6.5% of crustal earthquakes with Mw>4.5 occur above these regions with thick lithosphere. No earthquakes in our catalog with Mw>6 have occurred above mantle lithosphere with δVS>3.5%, although such lithosphere comprises 19% of stable continental regions. Thus, for cratonic interiors with seismically determined thick lithosphere (1) there is a significant decrease in the number of crustal earthquakes, and (2) the maximum moment magnitude found in the earthquake catalog is Mcmax=6.0. We attribute these observations to higher lithospheric strength beneath cratonic interiors due to lower temperatures and dehydration in both the lower crust and the highly depleted lithospheric root.

  17. Force-velocity properties of two avian hindlimb muscles.

    Nelson, Frank E; Gabaldón, Annette M; Roberts, Thomas J


    Recent work has provided measurements of power output in avian skeletal muscles during running and flying, but little is known about the contractile properties of avian skeletal muscle. We used an in situ preparation to characterize the force-velocity properties of two hind limb muscles, the lateral gastrocnemius (LG) and peroneus longus (PL), in Wild Turkeys (Meleagris gallopavo). A servomotor measured shortening velocity for at least six different loads over the plateau region of the length-tension curve. The Hill equation was fit to the data to determine maximum shortening velocity and peak instantaneous power. Maximum unloaded shortening velocity was 13.0+/-1.6 L s(-1) for the LG muscle and 14.8+/-1.0 L s(-1) for the PL muscle (mean+/-S.E.M.). These velocities are within the range of values published for reptilian and mammalian muscles. Values recorded for maximum isometric force per cross-sectional area, 271+/-28 kPa for the LG and 257+/-30.5 kPa for the PL, and peak instantaneous power output, 341.7+/-36.4 W kg(-1) for the LG and 319.4+/-42.5 W kg(-1) for the PL, were also within the range of published values for vertebrate muscle. The force-velocity properties of turkey LG and PL muscle do not reveal any extreme differences in the mechanical potential between avian and other vertebrate muscle.

  18. Contributions of the secondary jet to the maximum tangential velocity and to the collection efficiency of the fixed guide vane type axial flow cyclone dust collector

    Ogawa, Akira; Anzou, Hideki; Yamamoto, So; Shimagaki, Mituru


    In order to control the maximum tangential velocity Vθm(m/s) of the turbulent rotational air flow and the collection efficiency ηc (%) using the fly ash of the mean diameter XR50=5.57 µm, two secondary jet nozzles were installed to the body of the axial flow cyclone dust collector with the body diameter D1=99mm. Then in order to estimate Vθm (m/s), the conservation theory of the angular momentum flux with Ogawa combined vortex model was applied. The comparisons of the estimated results of Vθm(m/s) with the measured results by the cylindrical Pitot-tube were shown in good agreement. And also the estimated collection efficiencies ηcth (%) basing upon the cut-size Xc (µm) which was calculated by using the estimated Vθ m(m/s) and also the particle size distribution R(Xp) were shown a little higher values than the experimental results due to the re-entrainment of the collected dust. The best method for adjustment of ηc (%) related to the contribution of the secondary jet flow is principally to apply the centrifugal effect Φc (1). Above stated results are described in detail.

  19. Enhanced muscle shortening and impaired Ca2+ channel function in an acute septic myopathy model.

    Friedrich, Oliver; Hund, Ernst; von Wegner, Frederic


    Myopathies in critically ill patients are increasingly documented. Various animal models of chronic sepsis have been employed to investigate reduced membrane excitability or altered isometric contractility of skeletal muscle. In contrast, immediate changes occurring during acute sepsis are significantly under-characterised; L-type Ca(2+) channel function or isotonic shortening are examples. We recorded slowly activating L-type Ca(2+) currents (I (Ca)) in voltage-clamped single intact mouse skeletal muscle fibres and tested the effects of acute challenge with serum fractions from critical illness myopathy patients (CIM). Using a high-speed camera system, we simultaneously recorded unloaded fibre shortening during isotonic contractions with unprecedented temporal resolution (approximately 1,600 frames/s). Time courses of fibre lengths and shortening velocity were determined from automated imaging algorithms. CIM fractions acutely induced depression of I (Ca) amplitudes with no shifts in I (Ca)-V-relations. Voltage-dependent inactivation was unaltered and I (Ca) activation and inactivation kinetics were prolonged compared to controls. Unexpectedly, maximum unloaded speed of shortening was slightly faster following CIM serum applications, suggesting a direct action of CIM serum on weak-binding-state cross-bridges. Our results are compatible with a model where CIM serum might acutely reduce a fraction of functional L-type Ca(2+) channels and could account for reduced SR Ca(2+) release and force production in CIM patients. Acute increase in isotonic shortening velocity might be an early diagnostic feature suitable for testing in clinical studies. The acute challenge model is also robust against atrophy or fibre type changes that ordinarily would have to be considered in chronic sepsis models.

  20. Force depression decays during shortening in the medial gastrocnemius of the rat.

    Till, Olaf; Siebert, Tobias; Blickhan, Reinhard


    Force depression due to shortening of activated skeletal muscles has previously been described to be long lasting during isometric contractions following the shortening. In the present study, using the medial gastrocnemius of the rat, effects of force depression have been made apparent during shortening by computationally partially compensating for the direct effect of shortening velocity due to the tension-velocity relation. Evidence was found for the decay and complete disappearance of force depression already during continuation of the shortening contraction to short muscle lengths.

  1. Phenomenological models of the dynamics of muscle during isotonic shortening.

    Yeo, Sang Hoon; Monroy, Jenna A; Lappin, A Kristopher; Nishikawa, Kiisa C; Pai, Dinesh K


    We investigated the effectiveness of simple, Hill-type, phenomenological models of the force-length-velocity relationship for simulating measured length trajectories during muscle shortening, and, if so, what forms of the model are most useful. Using isotonic shortening data from mouse soleus and toad depressor mandibulae muscles, we showed that Hill-type models can indeed simulate the shortening trajectories with sufficiently good accuracy. However, we found that the standard form of the Hill-type muscle model, called the force-scaling model, is not a satisfactory choice. Instead, the results support the use of less frequently used models, the f-max scaling model and force-scaling with parallel spring, to simulate the shortening dynamics of muscle.

  2. Effects of errors in velocity tilt on maximum longitudinal compression during neutralized drift compression of intense beam pulses: II. Analysis of experimental data of the Neutralized Drift Compression eXperiment-I (NDCX-I)

    Massidda, Scott; Kaganovich, Igor D.; Startsev, Edward A.; Davidson, Ronald C.; Lidia, Steven M.; Seidl, Peter; Friedman, Alex


    Neutralized drift compression offers an effective means for particle beam focusing and current amplification with applications to heavy ion fusion. In the Neutralized Drift Compression eXperiment-I (NDCX-I), a non-relativistic ion beam pulse is passed through an inductive bunching module that produces a longitudinal velocity modulation. Due to the applied velocity tilt, the beam pulse compresses during neutralized drift. The ion beam pulse can be compressed by a factor of more than 100; however, errors in the velocity modulation affect the compression ratio in complex ways. We have performed a study of how the longitudinal compression of a typical NDCX-I ion beam pulse is affected by the initial errors in the acquired velocity modulation. Without any voltage errors, an ideal compression is limited only by the initial energy spread of the ion beam, ΔΕb. In the presence of large voltage errors, δU≫ΔEb, the maximum compression ratio is found to be inversely proportional to the geometric mean of the relative error in velocity modulation and the relative intrinsic energy spread of the beam ions. Although small parts of a beam pulse can achieve high local values of compression ratio, the acquired velocity errors cause these parts to compress at different times, limiting the overall compression of the ion beam pulse.

  3. Effects of errors in velocity tilt on maximum longitudinal compression during neutralized drift compression of intense beam pulses: II. Analysis of experimental data of the Neutralized Drift Compression eXperiment-I (NDCX-I)

    Massidda, Scott [Plasma Physics Laboratory, Princeton University, Princeton, NJ 08543 (United States); Kaganovich, Igor D., E-mail: [Plasma Physics Laboratory, Princeton University, Princeton, NJ 08543 (United States); Startsev, Edward A.; Davidson, Ronald C. [Plasma Physics Laboratory, Princeton University, Princeton, NJ 08543 (United States); Lidia, Steven M.; Seidl, Peter [Lawrence Berkeley National Laboratory, 1 Cyclotron Road, Berkeley, CA 94720 (United States); Friedman, Alex [Lawrence Livermore National Laboratory, 7000 East Avenue, Livermore, CA 94550 (United States)


    Neutralized drift compression offers an effective means for particle beam focusing and current amplification with applications to heavy ion fusion. In the Neutralized Drift Compression eXperiment-I (NDCX-I), a non-relativistic ion beam pulse is passed through an inductive bunching module that produces a longitudinal velocity modulation. Due to the applied velocity tilt, the beam pulse compresses during neutralized drift. The ion beam pulse can be compressed by a factor of more than 100; however, errors in the velocity modulation affect the compression ratio in complex ways. We have performed a study of how the longitudinal compression of a typical NDCX-I ion beam pulse is affected by the initial errors in the acquired velocity modulation. Without any voltage errors, an ideal compression is limited only by the initial energy spread of the ion beam, {Delta}{Epsilon}{sub b}. In the presence of large voltage errors, {delta}U Double-Nested-Greater-Than {Delta}E{sub b}, the maximum compression ratio is found to be inversely proportional to the geometric mean of the relative error in velocity modulation and the relative intrinsic energy spread of the beam ions. Although small parts of a beam pulse can achieve high local values of compression ratio, the acquired velocity errors cause these parts to compress at different times, limiting the overall compression of the ion beam pulse.

  4. Augmentation of deglutitive thyrohyoid muscle shortening by the Shaker Exercise.

    Mepani, Rachel; Antonik, Stephen; Massey, Benson; Kern, Mark; Logemann, Jerilyn; Pauloski, Barbara; Rademaker, Alfred; Easterling, Caryn; Shaker, Reza


    Earlier studies of the effect of 6 weeks of the Shaker Exercise have shown significant increase in UES opening and anterior excursion of larynx and hyoid during swallowing in patients with upper esophageal sphincter (UES) dysfunction, resulting in elimination of aspiration and resumption of oral intake. This effect is attributed to strengthening of the suprahyoid muscles, as evidenced by comparison of electromyographic changes in muscle fatigue before and after completion of the exercise regime. The effect of this exercise on thyrohyoid muscle shortening is unknown. Therefore the aim of this study was to determine the effect of the exercise on thyrohyoid muscle shortening. We studied 11 dysphagic patients with UES dysfunction. Six were randomized to traditional swallowing therapy and five to the Shaker Exercise. Videofluoroscopy was used to measure deglutitive thyrohyoid shortening before and after completion of assigned therapy regimen. Maximum thyrohyoid muscle shortening occurred at close temporal proximity to the time of maximal thyroid cartilage excursion. The percent change in thyrohyoid distance from initiation of deglutition to maximal anterior/superior hyoid excursion showed no statistically significant difference between the two groups prior to either therapy (p = 0.54). In contrast, after completion of therapy, the percent change in thyrohyoid distance in the Shaker Exercise group was significantly greater compared to the traditional therapy (p = 0.034). The Shaker Exercise augments the thyrohyoid muscle shortening in addition to strengthening the suprahyoid muscles. The combination of increased thyrohyoid shortening and suprahyoid strengthening contributes to the Shaker Exercise outcome of deglutitive UES opening augmentation.

  5. Results from transcranial Doppler examination on children and adolescents with sickle cell disease and correlation between the time-averaged maximum mean velocity and hematological characteristics: a cross-sectional analytical study

    Mary Hokazono

    Full Text Available CONTEXT AND OBJECTIVE: Transcranial Doppler (TCD detects stroke risk among children with sickle cell anemia (SCA. Our aim was to evaluate TCD findings in patients with different sickle cell disease (SCD genotypes and correlate the time-averaged maximum mean (TAMM velocity with hematological characteristics. DESIGN AND SETTING: Cross-sectional analytical study in the Pediatric Hematology sector, Universidade Federal de São Paulo. METHODS: 85 SCD patients of both sexes, aged 2-18 years, were evaluated, divided into: group I (62 patients with SCA/Sß0 thalassemia; and group II (23 patients with SC hemoglobinopathy/Sß+ thalassemia. TCD was performed and reviewed by a single investigator using Doppler ultrasonography with a 2 MHz transducer, in accordance with the Stroke Prevention Trial in Sickle Cell Anemia (STOP protocol. The hematological parameters evaluated were: hematocrit, hemoglobin, reticulocytes, leukocytes, platelets and fetal hemoglobin. Univariate analysis was performed and Pearson's coefficient was calculated for hematological parameters and TAMM velocities (P < 0.05. RESULTS: TAMM velocities were 137 ± 28 and 103 ± 19 cm/s in groups I and II, respectively, and correlated negatively with hematocrit and hemoglobin in group I. There was one abnormal result (1.6% and five conditional results (8.1% in group I. All results were normal in group II. Middle cerebral arteries were the only vessels affected. CONCLUSION: There was a low prevalence of abnormal Doppler results in patients with sickle-cell disease. Time-average maximum mean velocity was significantly different between the genotypes and correlated with hematological characteristics.

  6. Shortening Anomalies in Supersymmetric Theories

    Gomis, Jaume; Ooguri, Hirosi; Seiberg, Nathan; Wang, Yifan


    We present new anomalies in two-dimensional ${\\mathcal N} =(2, 2)$ superconformal theories. They obstruct the shortening conditions of chiral and twisted chiral multiplets at coincident points. This implies that marginal couplings cannot be promoted to background super-fields in short representations. Therefore, standard results that follow from ${\\mathcal N} =(2, 2)$ spurion analysis are invalidated. These anomalies appear only if supersymmetry is enhanced beyond ${\\mathcal N} =(2, 2)$. These anomalies explain why the conformal manifolds of the K3 and $T^4$ sigma models are not K\\"ahler and do not factorize into chiral and twisted chiral moduli spaces and why there are no ${\\mathcal N} =(2, 2)$ gauged linear sigma models that cover these conformal manifolds. We also present these results from the point of view of the Riemann curvature of conformal manifolds.

  7. T2 shortening in childhood moyamoya disease

    Takanashi, J. [Department of Pediatrics, Faculty of Medicine, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba-shi 260 (Japan); Sugita, K. [Department of Pediatrics, Faculty of Medicine, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba-shi 260 (Japan); Tanabe, Y. [Division of Neurology, Chiba Children`s Hospital, 579-1 Heta, Midori-ku, Chiba-shi 266 (Japan); Ito, C. [Division of Neurosurgery, Chiba Children`s Hospital, 579-1 Heta, Midori-ku, Chiba-shi 266 (Japan); Date, H. [Division of Neurosurgery, Chiba Children`s Hospital, 579-1 Heta, Midori-ku, Chiba-shi 266 (Japan); Niimi, H. [Department of Pediatrics, Faculty of Medicine, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba-shi 260 (Japan)


    We examined T2 shortening in six children with infarcts due to moyamoya disease to clarify whether there are characteristic patterns of T2 shortening in the deep grey and white matter. Profound T2 shortening in the deep grey and white matter was observed in the acute stage of infarct in two cases, which changed to high intensity in the chronic stage; in this stage no T2 shortening was demonstrated in any case. Neither haemorrhagic infarction nor calcification was seen on CT or MRI. There could be longitudinally different T2 shortening patterns between infarcts due to moyamoya disease and other disorders. (orig.). With 2 figs., 1 tab.

  8. Shortening behavior of the different components of muscle-tendon unit during isokinetic plantar flexions.

    Hauraix, Hugo; Nordez, Antoine; Dorel, Sylvain


    The torque-velocity relationship has been widely considered as reflecting the mechanical properties of the contractile apparatus, and the influence of tendinous tissues on this relationship obtained during in vivo experiments remains to be determined. This study describes the pattern of shortening of various muscle-tendon unit elements of the triceps surae at different constant angular velocities and quantifies the contributions of fascicles, tendon, and aponeurosis to the global muscle-tendon unit shortening. Ten subjects performed isokinetic plantar flexions at different preset angular velocities (i.e., 30, 90, 150, 210, 270, and 330°/s). Ultrafast ultrasound measurements were performed on the muscle belly and on the myotendinous junction of the medial and lateral gastrocnemius muscles. The contributions of fascicles, tendon, and aponeurosis to global muscle-tendon unit shortening velocity were calculated for velocity conditions for four parts of the total range of motion. For both muscles, the fascicles' contribution decreased throughout the motion (73.5 ± 21.5% for 100-90° angular range to 33.7 ± 20.2% for 80-70°), whereas the tendon contribution increased (25.8 ± 15.4 to 55.6 ± 16.8%). In conclusion, the tendon contribution to the global muscle-tendon unit shortening is significant even during a concentric contraction. However, this contribution depends on the range of motion analyzed. The intersubject variability found in the maximal fascicle shortening velocity, for a given angular velocity, suggests that some subjects might possess a more efficient musculoarticular complex to produce the movement velocity. These findings are of great interest for understanding the ability of muscle-tendon shortening velocity.

  9. The effect of hypoxia on shortening contractions in rat diaphragm muscle.

    Machiels, H.A.; Heijden, E. van der; Heunks, L.M.A.; Dekhuijzen, P.N.R.


    Hypoxia is known to reduce isometric contractile properties of isolated rat diaphragm bundles. Its effect on isotonic contractile properties (i.e. force-velocity relationship and power output) has not been studied. We hypothesized that hypoxia reduces velocity of shortening and consequently power ou

  10. 10 CFR 590.316 - Shortened proceedings.


    ... 10 Energy 4 2010-01-01 2010-01-01 false Shortened proceedings. 590.316 Section 590.316 Energy... WITH RESPECT TO THE IMPORT AND EXPORT OF NATURAL GAS Procedures § 590.316 Shortened proceedings. In any proceeding where, in response to a notice of application or notice of procedures, if applicable, no...

  11. Does the speed of shortening affect steady-state force depression in cat soleus muscle?

    Leonard, T R; Herzog, W


    It has been stated repeatedly for the past 50 years that the steady-state force depression following shortening of an activated muscle depends on the speed of shortening. However, these statements were based on results from experiments in which muscles were shortened at different speeds but identical activation levels. Therefore, the force during shortening was changed in accordance with the force-velocity relationship of muscles: that is, increasing speeds of shortening were associated with decreasing forces, and vice versa. Consequently, it is not possible at present to distinguish whether force depression is caused by the changes in speed, as frequently stated, or the associated changes in force, or both. The purpose of this study was to test if force depression depends on the speed of shortening. We hypothesized that force depression was dependent on the force but not the speed of contraction. Our prediction is that the amount of force depression after shortening contractions at different speeds could be similar if the force during contraction was controlled at a similar level. Cat soleus muscles (n=7) were shortened by 9 or 12 mm at speeds of 3, 9, and 27 mm/s, first with a constant activation during shortening (30Hz), then with activation levels that were reduced (shortening forces of the fast speed contractions (27 mm/s). If done properly, force depression could be precisely matched at the three different speeds, indicating that force depression was related to the force during the shortening contraction but not to the speed. However, in order to match force depression, the forces during shortening had to be systematically greater for the slow compared to the fast speeds of shortening, suggesting that force depression also depends on the level of activation, as force depression at constant activation levels can only be matched if the force during shortening, evaluated by the mechanical work, is identical. Therefore, we conclude that force depression depends

  12. Shortening-induced torque depression in old men: implications for age-related power loss.

    Power, Geoffrey A; Makrakos, Demetri P; Stevens, Daniel E; Herzog, Walter; Rice, Charles L; Vandervoort, Anthony A


    Following active muscle shortening, the steady-state isometric torque at the final muscle length is lower than the steady-state torque obtained for a purely isometric contraction at that same final muscle length. This well-documented property of skeletal muscle is termed shortening-induced torque depression (TD). Despite many investigations into the mechanisms of weakness and power loss in old age, the influence of muscle shortening on the history dependence of isometric torque production remains to be elucidated. Thus, it is unclear whether older adults are disadvantaged for torque and power production following a dynamic shortening contraction. The purpose of this study was to evaluate shortening-induced TD in older adults, and to determine whether shortening-induced TD is related to power loss. Maximal voluntary isometric dorsiflexion contractions (MVC; 10s) in 8 young (25.5±3.7years) and 9 old (76.1±5.4years) men were performed on a HUMAC NORM dynamometer as a reference, and then again following an active shortening of 40° joint excursion (40°PF-0°PF) at angular velocities of 15°/s and 120°/s. Work and instantaneous power were derived during shortening. Shortening-induced TD was calculated and expressed as a percentage by determining the mean torque value over 1s during the isometric steady state of the MVC following shortening, divided by the mean torque value for the same 1s time period during the isometric reference MVC. To assess muscle activation, electromyography (root mean square; EMGRMS) of the tibialis anterior (TA) and soleus (SOL) was calculated at identical time points used in assessing shortening-induced TD, and voluntary activation (VA) was assessed using the interpolated twitch technique. Old were 18% weaker than young for MVC, and ~40% less powerful for 15°/s and 120°/s of shortening. Old produced 37% and 21% less work for 15°/s and 120°/s than young, respectively. Furthermore, old experienced 60% and 70% greater shortening-induced TD

  13. The influence of loading intensity on muscle-tendon unit behavior during maximal knee extensor stretch shortening cycle exercise.

    Earp, Jacob E; Newton, Robert U; Cormie, Prue; Blazevich, Anthony J


    Tendon stiffness increases as the magnitude and rate of loading increases, according to its viscoelastic properties. Thus, under some loading conditions tendons should become exceptionally stiff and act almost as rigid force transducers. Nonetheless, observations of tendon behavior during multi-joint sprinting and jumping tasks have shown that tendon strain increases whilst muscle strain decreases as the loading intensity increases. The purpose of the current study was to examine the influence of external loading intensity on muscle-tendon unit (MTU) behavior during a high-speed single-joint, stretch-shortening cycle (SSC) knee extension task. Eighteen men (n = 9) and women (n = 9) performed single-leg, maximum intensity SSC knee extensions at loads of 20, 60 and 90% of their one repetition maximum. Vastus lateralis fascicle length (L(f)) and velocity (v(f)) as well as MTU (L(MTU)) and tendinous tissue (L(t)) length were measured using high-speed ultrasonography (96 Hz). Patellar tendon force (F(t)) and rate of force development (RFDt) were estimated using inverse dynamics. Results showed that as loading intensity increased, concentric joint velocity and shortening v f decreased whilst F t and RFDt increased, but no significant differences were observed in eccentric joint velocity or peak L(MTU) or L(f). In addition, the tendon lengthened significantly less at the end of the eccentric phase at heavier loads. This is the first observation that tendon strain decreases significantly during a SSC movement as loading intensity increases in vivo, resulting in a shift in the tendon acting as a power amplifier at light loads to a more rigid force transducer at heavy loads.

  14. Child Abuse May Shorten Some Women's Lives

    ... page: Child Abuse May Shorten Some Women's Lives Extreme stress may ... 300 middle-aged U.S. adults, female survivors of child abuse were more likely to die over the next ...

  15. Can Your Heartburn Meds Shorten Your Life?

    ... gov/news/fullstory_167005.html Can Your Heartburn Meds Shorten Your Life? Study found association between prolonged ... of Medicine, in St. Louis. "There was a relationship between duration of use and risk of death," ...

  16. Occlusal stability in shortened dental arches.

    Witter, D J; Creugers, N H; Kreulen, C M; de Haan, A F


    Shortened dental arches consisting of anterior and premolar teeth have been shown to meet oral functional demands. However, the occlusal stability may be at risk as a result of tooth migration. The aim of this nine-year study was to investigate occlusal stability in shortened dental arches as a function over time. Occlusal stability indicators were: 'interdental spacing', 'occlusal contacts of anterior teeth in Intercuspal Position', 'overbite', 'occlusal tooth wear', and 'alveolar bone support'. Subjects with shortened dental arches (n = 74) were compared with subjects with complete dental arches (controls, n = 72). Repeated-measurement regression analyses were applied to assess age-dependent variables in the controls and to relate the occlusal changes to the period of time since the treatment that led to the shortened dental arches. Compared with complete dental arches, shortened dental arches had similar overbite and occlusal tooth wear. They showed more interdental spacing in the premolar regions, more anterior teeth in occlusal contact, and lower alveolar bone scores. Since the differences remained constant over time, we conclude that shortened dental arches can provide long-term occlusal stability. Occlusal changes were self-limiting, indicating a new occlusal equilibrium.

  17. Maximum Fidelity

    Kinkhabwala, Ali


    The most fundamental problem in statistics is the inference of an unknown probability distribution from a finite number of samples. For a specific observed data set, answers to the following questions would be desirable: (1) Estimation: Which candidate distribution provides the best fit to the observed data?, (2) Goodness-of-fit: How concordant is this distribution with the observed data?, and (3) Uncertainty: How concordant are other candidate distributions with the observed data? A simple unified approach for univariate data that addresses these traditionally distinct statistical notions is presented called "maximum fidelity". Maximum fidelity is a strict frequentist approach that is fundamentally based on model concordance with the observed data. The fidelity statistic is a general information measure based on the coordinate-independent cumulative distribution and critical yet previously neglected symmetry considerations. An approximation for the null distribution of the fidelity allows its direct conversi...

  18. Effects of muscle fibre shortening on the characteristics of surface motor unit potentials.

    Rodriguez-Falces, Javier; Place, Nicolas


    Traditionally, studies dealing with muscle shortening have concentrated on assessing its impact on conduction velocity, and to this end, electrodes have been located between the end-plate and tendon regions. Possible morphologic changes in surface motor unit potentials (MUPs) as a result of muscle shortening have not, as yet, been evaluated or characterized. Using a convolutional MUP model, we investigated the effects of muscle shortening on the shape, amplitude, and duration characteristics of MUPs for different electrode positions relative to the fibre-tendon junction and for different depths of the MU in the muscle (MU-to-electrode distance). It was found that the effects of muscle shortening on MUP morphology depended not only on whether the electrodes were between the end-plate and the tendon junction or beyond the tendon junction, but also on the specific distance to this junction. When the electrodes lie between the end-plate and tendon junction, it was found that (1) the muscle shortening effect is not important for superficial MUs, (2) the sensitivity of MUP amplitude to muscle shortening increases with MU-to-electrode distance, and (3) the amplitude of the MUP negative phase is not affected by muscle shortening. This study provides a basis for the interpretation of the changes in MUP characteristics in experiments where both physiological and geometrical aspects of the muscle are varied.


    YU Jin-hua


    A high resolution shallow-water model is designed to study the roles which the topographical parameter and latitudinal basic flow play in the propagation of vortex Rossby waves and typhoon tangential velocity changes. With no latitudinal flow, the horizontal scale effects of island terrain on the vortex Rossby waves propagation show that the disturbance vorticity follows a clockwise island-circulating path more significantly, the local maximum wind speed amplitude reduces more sharply, the maximum mean azimuthally tangential wind spins down more substantially, when the topographic horizontal scale augments. With the latitudinal basic flow, the evolution of local wind and mean velocity are affected by the distance changes between TC and the terrain and the time length of topographic action: the local wind amplitude intensifies and the mean velocity diminishes while the distance is shortening; the opposite is true while TC is away from the terrain gradually.

  20. Effects of fiber type on force depression after active shortening in skeletal muscle.

    Joumaa, V; Power, G A; Hisey, B; Caicedo, A; Stutz, J; Herzog, W


    The aim of this study was to investigate force depression in Type I and Type II muscle fibers. Experiments were performed using skinned fibers from rabbit soleus and psoas muscles. Force depression was quantified after active fiber shortening from an average sarcomere length (SL) of 3.2µ m to an average SL of 2.6 µm at an absolute speed of 0.115f iber length/s and at a relative speed corresponding to 17% of the unloaded shortening velocity (V0) in each type of fibers. Force decay and mechanical work during shortening were also compared between fiber types. After mechanical testing, each fiber was subjected to myosin heavy chain (MHC) analysis in order to confirm its type (Type I expressing MHC I, and Type II expressing MHC IId). Type II fibers showed greater steady-state force depression after active shortening at a speed of 0.115 fiber length/s than Type I fibers (14.5±1.5% versus 7.8±1.7%). Moreover, at this absolute shortening speed, Type I fibers showed a significantly greater rate of force decay during shortening and produced less mechanical work than Type II fibers. When active shortening was performed at the same relative speed (17% V0), the difference in force depression between fiber types was abolished. These results suggest that no intrinsic differences were at the origin of the disparate force depressions observed in Type I and Type II fibers when actively shortened at the same absolute speed, but rather their distinct force-velocity relationships.

  1. Influence of sex on performance fatigability of the plantar flexors following repeated maximal dynamic shortening contractions.

    Lanning, Amelia C; Power, Geoffrey A; Christie, Anita D; Dalton, Brian H


    The purpose was to determine sex differences in fatigability during maximal, unconstrained velocity, shortening plantar flexions. The role of time-dependent measures (i.e., rate of torque development, rate of velocity development, and rate of neuromuscular activation) in such sex-related differences was also examined. By task termination, females exhibited smaller reductions in power and similar changes in rate of neuromuscular activation than males, indicating females were less fatigable than males.

  2. Shortening Scarf osteotomy for correction of severe hallux valgus. Does shortening affect the outcome?

    Karpe, Prasad; Killen, Marie C; Pollock, Raymond D; Limaye, Rajiv


    Translation and shortening of Scarf osteotomy allows correction of severe hallux valgus deformity. Shortening may result in transfer metatarsalgia. To evaluate outcome of patients undergoing shortening Scarf osteotomy for severe hallux valgus deformities. Fifteen patients (20feet, mean age 58 years) underwent shortening Scarf osteotomy for severe hallux valgus deformities. Outcomes were pre and postoperative AOFAS scores, IM and HV angles, patient satisfaction. Mean follow-up was 25 months (range 22-30). The IM angle improved from a median of 18.60 (range 13.4-26.20) preoperatively to 9.70 (range 8.0-13.70) postoperatively (8.9; 95% CI=7.6-10.3; posteotomies united. Shortening Scarf osteotomy is a viable option for treating severe hallux valgus deformities with no transfer metatarsalgia. Copyright © 2016 Elsevier Ltd. All rights reserved.

  3. Numerical Simulation of Pulse Shortening in RBWOs

    GONG Yu-bin; ZHANG Zhang; WANG Wen-xiang; MENG Fan-bao; FAN Zhi-kai; HUANG Min-zhi


    Pulse shortening hinders improvement of microwave output energy for high power microwave tubes. So far, it is also an unresolved problem in the field of high power microwave devices. In this paper, relativistic backward wave tube (RBWO) is treated as an example to study the pulse shortening phenomena. The influences of gas existing in the tube and explosive emission in inner surface of RBWO are all investigated by means of the particle-in-cell method. Through the simulation results, it can be predicted that the background gas in the tube is one but not the most important factor resulting in pulse shortening, in order to broaden the pulse width of gas-filled RBWO, the pressure of the filled gas must be controlled in a proper value. The explosive emission in the surface of slow wave structure due to intense electric field is one of the most important factors causing pulse shortening in high power microwave tube.Some methods to overcome this find of explosive emission are also given.

  4. 9 CFR 319.701 - Mixed fat shortening.


    ... 9 Animals and Animal Products 2 2010-01-01 2010-01-01 false Mixed fat shortening. 319.701 Section... INSPECTION AND CERTIFICATION DEFINITIONS AND STANDARDS OF IDENTITY OR COMPOSITION Fats, Oils, Shortenings § 319.701 Mixed fat shortening. Shortening prepared with a mixture of meat fats and vegetable oils...

  5. Tetanic force potentiation of mouse fast muscle is shortening speed dependent.

    Gittings, William; Huang, Jian; Vandenboom, Rene


    The activity dependent potentiation of peak isometric force associated with phosphorylation of the myosin regulatory light chain (RLC) is generally restricted to low activation frequencies. The purpose of this study was to determine if muscle shortening speed influenced the stimulus frequency domain over which concentric force potentiation was observed. To this end, mouse extensor digitorum longus (EDL) muscles (in vitro, 25 °C) were activated at a range of test frequencies (10, 25, 45, 70 or 100 Hz) during shortening ramps at 0.10, 0.30 or 0.50 of the maximal velocity of shortening (V(max)). This procedure was performed before and after a standard conditioning stimulus (CS) that elevated RLC phosphorylation from 0.08 ± 0.01 (rest) to 0.55 ± 0.01 (stimulated) moles phosphate per mol RLC, respectively (n = 9-11) (P shortening speed also increased the activation frequency at which concentric force potentiation was maximal, i.e. from 10 Hz at 0.10 V(max) to 10-25 and 25-45 Hz at 0.30 and 0.50 V(max), respectively. These results indicate that both the magnitude of and activation frequency dependence for concentric force potentiation of mouse EDL muscle is shortening speed dependent. Thus, muscle shortening speed may be a critical factor determining the functional utility of the myosin RLC phosphorylation mechanism.

  6. Energy velocity and group velocity



    A new Lagrangian method for studying the relationship between the energy velocity and the group velocity is described. It is proved that under the usual quasistatic electric field, the energy velocity is identical to the group velocity for acoustic waves in anisotropic piezoelectric (or non-piezoelectric) media.

  7. Structural limits on force production and shortening of smooth muscle.

    Siegman, Marion J; Davidheiser, Sandra; Mooers, Susan U; Butler, Thomas M


    This study determined the factors that limit force production and shortening in two smooth muscles having very different relationships between active and passive force as a function of muscle length. The rat anococcygeus muscle develops active force over the range of lengths 0.2-2.0× the optimum length for force production (Lo). Passive tension due to extension of the resting muscle occurs only at lengths exceeding Lo. In contrast, the rabbit taenia coli develops force in the range of lengths 0.4-1.1 Lo, and passive force which is detectable at 0.56 Lo, increases to ~0.45 maximum active force at Lo, and increases sharply with further extension. The anococcygeus muscle can shorten to 0.2 Lo and the taenia coli to 0.4 Lo. Dynamic stiffness and energy usage at short muscle lengths suggest that the limit of shortening in the taenia coli, in contrast to the anococcygeus muscle, is not due to a failure of cross bridge interaction. Phosphorylation of the regulatory myosin light chains in intact muscles decreased to a small extent at short lengths compared to the decrease in force production. The differences in force production and the extent of shortening in the two muscles was maintained even when, following permeabilization, the myosin light chains were irreversibly phosphorylated with ATPγS, indicating that differences in activation played little, if any role. Ultrastructural studies on resting and activated muscles show that the taenia coli, which is rich in connective tissue (unlike the anococcygeus muscle) undergoes marked cellular twisting and contractile filament misalignment at short lengths with compression of the extracellular matrix. As a result, force is not transmitted in the longitudinal axis of the muscle, but is dissipated against an internal load provided by the compressed extracellular matrix. These observations on two very different normal smooth muscles reveal how differences in the relative contribution of active and passive structural elements

  8. Changes in conformation of myosin heads during the development of isometric contraction and rapid shortening in single frog muscle fibres.

    Piazzesi, G; Reconditi, M; Dobbie, I; Linari, M; Boesecke, P; Diat, O; Irving, M; Lombardi, V


    1. Two-dimensional X-ray diffraction patterns were recorded at the European Synchrotron Radiation Facility from central segments of intact single muscle fibres of Rana temporaria with 5 ms time resolution during the development of isometric contraction. Shortening at ca 0.8 times the maximum velocity was also imposed at the isometric tetanus plateau. 2. The first myosin-based layer line (ML1) and the second myosin-based meridional reflection (M2), which are both strong in resting muscle, were completely abolished at the plateau of the isometric tetanus. The third myosin-based meridional reflection (M3), arising from the axial repeat of the myosin heads along the filaments, remained intense but its spacing changed from 14.34 to 14.56 nm. The intensity change of the M3 reflection, IM3, could be explained as the sum of two components, I14.34 and I14.56, arising from myosin head conformations characteristic of rest and isometric contraction, respectively. 3. The amplitudes (A) of the X-ray reflections, which are proportional to the fraction of myosin heads in each conformation, changed with half-times that were similar to that of isometric force development, which was 33.5 +/- 2. 0 ms (mean +/- s.d., 224 tetani from three fibres, 4 C), measured from the end of the latent period. We conclude that the myosin head conformation changes synchronously with force development, at least within the 5 ms time resolution of these measurements. 4. The changes in the X-ray reflections during rapid shortening have two temporal components. The rapid decrease in intensity of the 14.56 nm reflection at the start of shortening is likely to be due to tilting of myosin heads attached to actin. The slower changes in the other reflections were consistent with a return to the resting conformation of the myosin heads that was about 60 % complete after shortening of 70 nm per half-sarcomere.

  9. Shortening amplitude affects the incomplete force recovery after active shortening in mouse soleus muscle.

    Van Noten, Pieter; Van Leemputte, Marc


    Compared to isometric contraction, the force producing capacity of muscle is reduced (force depression, FD) after a work producing shortening phase. It has been suggested that FD results from an inhibition of cross-bridge binding. Because the rate constants of the exponential force (re)development are thought to be primarily determined by cross-bridge attachment/detachment rate, we aimed to investigate the components of force redevelopment (REDEV) after 0.6, 1.2 and 2.4mm shortening, resulting in varying amounts of FD (from about 5% to about 16%), in mouse soleus muscle (n=11). Compared to isometric force development (DEV), the time to reach steady-state during REDEV was about 3 times longer (370 versus 1261ms) increasing with increasing amplitude. Contrary to a single, a double exponential function with one component set equal to the rate constant of DEV (14.3s(-1)), accurately described REDEV (RMSshortening amplitude and was associated with work delivered during shortening (R(2)=0.75) and FD (R(2)=0.77). We concluded that a work related slow exponential component is induced to the trajectory of incomplete force recovery after shortening, causing FD. These results suggest that after shortening, aside from cross-bridges with normal attachment/detachment rate, cross-bridges with reduced cycling rate are active.

  10. Renal failure induces telomere shortening in the rat heart

    Wong, L. S.; Windt, W. A.; Roks, A. J.; van Dokkum, R. P.; Schoemaker, R. G.; de Zeeuw, D.; Henning, R. H.


    Background. Renal failure aggravates pathological cardiac remodelling induced by myocardial infarction (MI). Cardiac remodelling is associated with telomere shortening, a marker for biological ageing. We investigated whether mild and severe renal failure shorten cardiac telomeres and excessively sho

  11. [Shortening arthrodesis of three wrist bones].

    Delattre, O; Dupont, P; Reau, A F; Rouvillain, J L; Mousselard, H; Catonné, Y


    In advanced cases of wrist osteoarthritis with lesions of the radio-scaphoid and mediocarpal joints, and when a proximal row carpectomy is not possible because of lesions of the head of the capitate, we suggest a new technique: The hamate-capitate-lunate shortening arthrodesis with a scaphoid-triquetral resection. The good results observed with proximal row carpectomies, and particularly their long-term reliability, have encouraged us on this new path. Effectively, this operation takes the concept of proximal row carpectomy one step further by reconstructing the head of the capitate with the lunate whose proximal articular surface is often not deteriorated even in very advanced cases of radio and mediocarpal osteoarthritis. The two theoretical concepts of this operation are the shortening of the carpus and respect of the physiological congruence of the radio-lunate joint, the goal being obtain similar results those with proximal row carpectomy, particularly concerning mobility. We present our first two cases with this technique. This new procedure is an alternative to the four bone arthrodesis, particularly in SLAC wrist sequellae when they have evolved to the stage of radio and mediocarpal osteoarthritis.

  12. Spine biomechanics associated with the shortened, modern one-plane golf swing.

    Dale, R Barry; Brumitt, Jason


    The purpose of this study was to compare kinetic, kinematic, and performance variables associated with full and shortened modern backswings in a skilled group of modern swing (one-plane) golfers. Shortening the modern golf backswing is proposed to reduce vertebral spine stress, but supporting evidence is lacking and performance implications are unknown. Thirteen male golfers performed ten swings of each swing type using their own 7-iron club. Biomechanical-dependent variables included the X-Factor kinematic data and spine kinetics. Performance-related dependent variables included club head velocity (CHV), shot distance, and accuracy (distance from the target line). Data were analysed with repeated measures ANOVA with an a priori alpha of 0.05 (SPSS 22.0, IBM, Armonk, NY, USA). We found significant reductions for the X-Factor (p < 0.05) between the full and shortened swings. The shortened swing condition ameliorated vertebral compression force from 7.6 ± 1.4 to 7.0 ± 1.7 N (normalised to body weight, p = 0.01) and significantly reduced CHV (p < 0.05) by ~2 m/s with concomitant shot distance diminution by ~10 m (p < 0.05). Further research is necessary to examine the applicability of a shortened swing for golfers with low back pain.

  13. Stretch-shortening cycle muscle power in women and men aged 18-81 years

    Edwén, C E; Thorlund, Jonas Bloch; Magnusson, Stig Peter;


    This study explored the age-related deterioration in stretch-shortening cycle (SSC) muscle power and concurrent force-velocity properties in women and men across the adult life span. A total of 315 participants (women: n = 188; men: n = 127) aged 18-81 years performed maximal countermovement jump...... on an instrumented force plate. Maximal SSC leg extension power expressed per kg body mass (Ppeak) was greater in men than in women across the adult age span (P ......This study explored the age-related deterioration in stretch-shortening cycle (SSC) muscle power and concurrent force-velocity properties in women and men across the adult life span. A total of 315 participants (women: n = 188; men: n = 127) aged 18-81 years performed maximal countermovement jumps...

  14. Depressant effect of active shortening in the anterior byssus retractor muscle of Mytilus edulis.

    Ekelund, M C


    The effect of shortening during activity, previously characterized in vertebrate striated muscle, was investigated in the anterior byssus retractor muscle (ABRM) of the mollusc Mytilus edulis. This muscle is considered to have an essentially myosin-linked Ca2+-regulatory system. Release steps of different amplitude were performed during isometric phasic contraction, and force redevelopment was recorded at a muscle length L1, defined as 90% of the muscle length at which a slight resting tension, approximately 1 mN, appeared in the presence of 2.5 X 10(-5) M 5-HT. Active shortening caused a graded depression of the contractile force without affecting the total duration of the mechanical response. Peak redeveloped force after muscle shortening of 0.06 L1 and 0.18 L1 was reduced by approximately 1.5% and 7.0%, respectively, of the isometric tension value at L1. The shortening effect was fully reversible, and had a lifetime of approximately 8 to 9 s. The depressant effect of active shortening was augmented at a reduced degree of activation of the muscle. The presence of caffeine and dantrolene and altered tonicity of the extracellular medium (0.9 T-1.2 T) did not significantly affect the shortening induced depression obtained at maximum phasic activation of the preparation. The nature of the shortening effect is compared to that obtained in vertebrate striated muscle and is discussed on the basis of differences in Ca2+-regulation of the contractile system in these two muscles.

  15. The effect of muscle length on force depression after active shortening in soleus muscle of mice.

    Van Noten, Pieter; Van Leemputte, Marc


    Isometric muscle force after active shortening is reduced [force depression (FD)]. The mechanism is incompletely understood but work delivered during shortening has been suggested to be the main determinant of FD. However, whether muscle length affects the sensitivity of FD to work is unknown, although this information might add to the understanding of the phenomenon. The aim of this study is to investigate the length dependence of the FD/work ratio (Q). Therefore, isometric force production (ISO) of 10 incubated mouse soleus muscles was compared to isometric force after 0.6, 1.2, and 2.4 mm shortening (IAS) at different end lengths ranging from L(0) - 3 to L(0) + 1.8 mm in steps of 0.6 mm. FD was calculated as the force difference between an ISO and IAS contraction at the same activation time (6 s) and end length. We confirm the strong relation between FD and work at L(0) (R² = 0.92) and found that FD is length dependent with a maximum of 8.8 ± 0.3% at L(0) + 1.2 mm for 0.6 mm shortening amplitude. Q was only constant for short muscle lengths (muscle length. The observed length dependence of Q indicates that FD is not only determined by work produced during shortening but also by a length-dependent factor, possibly actin compliance, which should be incorporated in any mechanism explaining FD.

  16. Effect of concentric and eccentric velocity during heavy-load non-ballistic elbow flexion resistance exercise.

    Sampson, John A; Donohoe, Alison; Groeller, Herbert


    Mechanical and neuromuscular benefits arise during ballistic stretch-shortening cycle muscle activation, yet resistance training regimens are typically non-ballistic, and in contrast to ballistic movement, require a concentric deceleration phase. Twelve healthy males performed a unilateral, six repetition maximum non-ballistic elbow flexion-extension task during; (i) rapid shortening (RS), (ii) stretch-shortening cycle (SSC) and (iii) a 2-s eccentric and 2-s concentric control (C). A load cell and shaft encoder recorded respectively force and velocity. Surface electromyographic root mean square amplitude (EMGRMS) was recorded in the biceps and triceps brachii, and is reported as the relative (%) difference, normalised to control (C). The average lengthening and shortening velocity of SSC (0.57 ± 0.03 ms(-1); 0.43 ± 0.02 ms(-1)) was significantly greater than RS (0.22 ± 0.01 ms(-1); 0.35 ± 0.01 ms(-1)), and C (0.17 ± 0.00 ms(-1), 0.20 ± 0.00 ms(-1)). Peak eccentric force was increased (PEccentric EMGRMS in the biceps brachii was significantly increased during the first three and final repetitions of SSC (31.9 ± 10.9%, 46.7 ± 12.4, 69.3 ± 13.6%, 92.0 ± 16.4%), and the third and last repetitions of RS (35.9 ± 7.4%, 50.3 ± 10.9%), compared to C (0.00%, 15.8 ± 4.0%, 23.7 ± 4.1%, 39.2 ± 8.6%). In the current study, eccentric limb velocity potentiated eccentric and concentric force, concentric velocity, and eccentric EMG amplitude during non-ballistic exercise. Crown Copyright © 2013. Published by Elsevier Ltd. All rights reserved.

  17. Folder: a MATLAB-based tool for modelling deformation in layered media subject to layer parallel shortening or extension

    Adamuszek, Marta; Dabrowski, Marcin; Schmid, Daniel W.


    We present Folder, a numerical tool to simulate and analyse the structure development in mechanically layered media during the layer parallel shortening or extension. Folder includes a graphical user interface that allows for easy designing of complex geometrical models, defining material parameters (including linear and non-linear rheology), and specifying type and amount of deformation. It also includes a range of features that facilitate the visualization and examination of various relevant quantities e.g. velocities, stress, rate of deformation, pressure, and finite strain. Folder contains a separate application, which illustrates analytical solutions of growth rate spectra for layer parallel shortening and extension of a single viscous layer. In the study, we also demonstrate a Folder application, where the role of confinement on the growth rate spectrum and the fold shape evolution during the deformation of a single layer subject to the layer parallel shortening is presented. In the case of the linear viscous materials used for the layer and matrix, the close wall proximity leads to a decrease of the growth rate values. The decrease is more pronounced for the larger wavelengths than for the smaller wavelengths. The growth rate reduction is greater when the walls are set closer to the layer. The presence of the close confinement can also affect the wavelength selection process and significantly shift the position of the dominant wavelength. The influence of the wall proximity on the growth rate spectrum for the case of non-linear viscous materials used for the layer and/or matrix is very different as compared to the linear viscous case. We observe a multiple maxima in the growth rate spectrum. The number of the growth rate maxima, their value and the position strongly depend on the closeness of the confinement. The maximum growth rate value for a selected range of layer-wall distances is much larger than in the case when the confinement effect is not taken

  18. Ulnar or radial shortening osteotomy with a single saw cut.

    Sraj, Shafic A; Budoff, Jeffrey E


    To determine which currently commercially available saw blades could be held at 45 degrees to the bone to reproducibly provide 2.0, 2.5, and 3.0 mm of ulna or radius shortening. Commercially available saw blades were tested for their ability to achieve the osseous shortening at a 45 degrees angle cut. When held at a 45 degrees angle to the bone, 2 Stryker 0.64-mm-thick blades achieved a mean shortening of 2.0 mm. A single Linvatec 1.2-mm-thick blade achieved a mean osseous shortening of 2.1 mm. Two Dyonics 0.65-mm-thick blades achieved a mean osseous shortening of 2.7 mm. Two Dyonics 0.89-mm-thick saw blades achieved a mean osseous shortening of 3.1 mm. Three Stryker 0.38-mm-thick saw blades mounted with the middle blade "upside down" with regard to the 2 outer blades achieved a mean osseous shortening of 3.2 mm. Two Linvatec 0.8-mm-thick saw blades achieved a mean osseous shortening of 3.1 mm. The findings of this study can help guide surgeons who desire to reproducibly shorten the ulna or radius by 2.0, 2.7, or 3.2 mm using a single saw cut to ensure a parallel osteotomy gap.

  19. Variability in New Shortening Estimates from Southern Peru (12-14S); Implications for Mass Balance of the Andean Plateau.

    Gotberg, N.; McQuarrie, N.


    One of the fundamental questions of interest with regards to the Andean Plateau is the mass balance of material needed to create and sustain a 3-4 km high plateau. Is crustal shortening sufficient to support an isostatically compensated crust of 60-70km? We present new estimates of shortening across the northern margin of the Andean Plateau. The cross section extent, from the eastern edge of the volcanic arc to foreland basin, is approximately one half of the physiographic width of the Andean Plateau in Peru. Cross sectional shortening estimates in southern Peru (12-14°S) provide a best estimate of 123 km or 40% shortening with an absolute minimum estimate of 86 km or 30% and absolute maximum estimate of 275 km or 60%. We determined the maximum and minimum shortening estimates using the cross sectional area and possible variations in assumptions made about the amount of erosion, detachment dip, involvement of basement thrusts and displacement along faults. The best estimate of shortening is well short of the required 240-300km of shortening needed in order to account for a 60-70km thick crust under the entire plateau. This suggests that for an isostatically equilibrated crust either 1) there is a significant amount of shortening (~150km) in the western half of the plateau which, is hidden by the volcanic arc or 2) crustal material is being added to the Peruvian section of the Andean Plateau either through lower crustal flow or a process of magmatic underplating followed by differentiation and delamination.

  20. The maximum rotation of a galactic disc

    Bottema, R


    The observed stellar velocity dispersions of galactic discs show that the maximum rotation of a disc is on average 63% of the observed maximum rotation. This criterion can, however, not be applied to small or low surface brightness (LSB) galaxies because such systems show, in general, a continuously

  1. Modulation of corticospinal excitability during lengthening and shortening contractions in the first dorsal interosseus muscle of humans.

    Sekiguchi, Hirofumi; Kohno, Yutaka; Hirano, Tatsuya; Akai, Masami; Nakajima, Yasoichi; Nakazawa, Kimitaka


    Lengthening and shortening contractions are the fundamental patterns of muscle activation underlying various movements. It is still unknown whether or not there is a muscle-specific difference in such a fundamental pattern of muscle activation. The purpose of this study was, therefore, to investigate whether or not the relationship between lengthening and shortening contractions in the modulation of corticospinal excitability in the first dorsal interosseus (FDI) muscle is the same as that of previously tested muscles because the hand muscles are anatomically and functionally different from the other muscles. To this end, we investigated the relationship between the input-output curves of the corticospinal pathway (i.e., the relationship between the stimulus intensities vs. the area of motor-evoked potentials) during lengthening and shortening contractions in 17 healthy subjects. The shape of this relationship was sigmoidal and characterized by a plateau value, maximum slope, and threshold. The plateau value was at the same level between lengthening and shortening contractions. However, the maximum slope (P shortening contractions. These findings were different from the results of other muscles tested in previous studies (i.e., the soleus muscle and the elbow flexors). That is to say, the plateau value and the maximum slope during lengthening contractions were significantly lower than those during shortening contractions in previous studies. This study provides tentative evidence that the relationship between lengthening and shortening contractions in the modulation of corticospinal excitability differs between muscles, indicating that the underlying neural control is not necessarily the same even though the fundamental patterns of muscle activation are carried out.

  2. Accelerated Telomere Shortening in Acromegaly; IGF-I Induces Telomere Shortening and Cellular Senescence

    Matsumoto, Ryusaku; Fukuoka, Hidenori; Iguchi, Genzo; Odake, Yukiko; Yoshida, Kenichi; Bando, Hironori; Suda, Kentaro; Nishizawa, Hitoshi; Takahashi, Michiko; Yamada, Shozo; Ogawa, Wataru; Takahashi, Yutaka


    Objective Patients with acromegaly exhibit reduced life expectancy and increased prevalence of age-related diseases, such as diabetes, hypertension, and cardiovascular disease. However, the underlying mechanism has not been fully elucidated. Telomere shortening is reportedly associated with reduced life expectancy and increased prevalence of these age-related diseases. Methods We measured telomere length in patients with acromegaly using quantitative PCR method. The effect of GH and IGF-I on telomere length and cellular senescence was examined in human skin fibroblasts. Results Patients with acromegaly exhibited shorter telomere length than age-, sex-, smoking-, and diabetes-matched control patients with non-functioning pituitary adenoma (0.62 ± 0.23 vs. 0.75 ± 0.35, respectively, P = 0.047). In addition, telomere length in acromegaly was negatively correlated with the disease duration (R2 = 0.210, P = 0.003). In vitro analysis revealed that not GH but IGF-I induced telomere shortening in human skin fibroblasts. Furthermore, IGF-I-treated cells showed increased senescence-associated β-galactosidase activity and expression of p53 and p21 protein. IGF-I-treated cells reached the Hayflick limit earlier than GH- or vehicle-treated cells, indicating that IGF-I induces cellular senescence. Conclusion Shortened telomeres in acromegaly and cellular senescence induced by IGF-I can explain, in part, the underlying mechanisms by which acromegaly exhibits an increased morbidity and mortality in association with the excess secretion of IGF-I. PMID:26448623

  3. Force generation examined by laser temperature-jumps in shortening and lengthening mammalian (rabbit psoas) muscle fibres.

    Ranatunga, K W; Coupland, M E; Pinniger, G J; Roots, H; Offer, G W


    We examined the tension change induced by a rapid temperature jump (T-jump) in shortening and lengthening active muscle fibres. Experiments were done on segments of permeabilized single fibres (length (L0) approximately 2 mm, sarcomere length 2.5 microm) from rabbit psoas muscle; [MgATP] was 4.6 mm, pH 7.1, ionic strength 200 mm and temperature approximately 9 degrees C. A fibre was maximally Ca2+-activated in the isometric state and a approximately 3 degrees C, rapid (shortening or ramp lengthening at a limited range of velocities (0-0.2 L0 s(-1)). The tension increased to 2- to 3 x P0 (isometric force) during ramp lengthening at velocities > 0.05 L0 s(-1), whereas the tension decreased to about shortening at 0.1-0.2 L0 s(-1); the unloaded shortening velocity was approximately 1 L0 s(-1) and the curvature of the force-shortening velocity relation was high (a/P0 ratio from Hill's equation of approximately 0.05). In isometric state, a T-jump induced a tension rise of 15-20% to a new steady state; by curve fitting, the tension rise could be resolved into a fast (phase 2b, 40-50 s(-1)) and a slow (phase 3, 5-10 s(-1)) exponential component (as previously reported). During steady lengthening, a T-jump induced a small instantaneous drop in tension, followed by recovery, so that the final tension recorded with and without a T-jump was not significantly different; thus, a T-jump did not lead to a net increase of tension. During steady shortening, the T-jump induced a pronounced tension rise and both its amplitude and the rate (from a single exponential fit) increased with shortening velocity; at 0.1-0.2 L0 s(-1), the extent of fibre shortening during the T-jump tension rise was estimated to be approximately 1.2% L(0) and it was shorter at lower velocities. At a given shortening velocity and over the temperature range of 8-30 degrees C, the rate of T-jump tension rise increased with warming (Q10 approximately 2.7), similar to phase 2b (endothermic force generation) in

  4. To the problem of cross-bridge tension in steady muscle shortening and lengthening

    Kokshenev, Valery B


    Despite the great success of the Huxley sliding filament model proposed half a century ago for actin-myosin linkages (cross-bridges), it fails to explain the force-velocity behavior of stretching skeletal muscles. Huxley's two-state kinetic equation for cross-bridge proportions is therefore reconsidered and a new solution to the problem of steady muscle eccentric and concentric contractions is reported. When the second law of statistical thermodynamics is applied to cross-bridge proportions, the weakly bound states appear to be correlated to the strongly bound states via structural and kinetic intrinsic muscle characteristics. The explicit force-velocity curve fits the empirical tension-velocity data on frog muscle shortening using only one adjustable parameter, while the Huxley model employed four parameters.

  5. Does postsystolic motion or shortening predict recovery of myocardial function after primary percutanous coronary intervention?

    Terkelsen, Christian Juhl; Poulsen, Steen Hvitfeldt; Nørgaard, Bjarne Linde;


    or shortening appears more frequently in the acute phase in myocardial segments with impaired systolic function compared with normally functioning segments. However, presence of postsystolic contraction is not associated with improvement in strain or wall-motion score at follow-up, and does not seem......OBJECTIVE: The purpose of the study was to evaluate whether presence of postsystolic motion or shortening defined by Doppler tissue imaging may predict recovery of regional myocardial function in patients with ST-elevation myocardial infarction. METHODS: Echocardiography was performed a few hours......); and normal myocardial function in the acute phase (type E, n = 759). RESULTS: There were no differences among type A, B, C, and D segments with regard to the proportion presenting postsystolic tissue velocity equal to or greater than 1.0 cm/s (0.52, 0.54, 0.60, and 0.47, respectively, P = .20...

  6. Does a detection team shorten duration of untreated psychosis?

    Nordentoft, Merete; Thorup, Anne; Petersen, Lone;


    Duration of untreated psychosis (DUP) is shown to be associated with poor outcome in many domains. It has been shown that it is possible to shorten DUP when combining a detection team and an information campaign. The aim of this study was to evaluate whether DUP was shortened during the first 3 y...

  7. Instability during bunch shortening of an electron-cooled beam

    M. Takanaka


    Full Text Available Bunch shortening causes an electron-cooled beam to be space charge dominated at low energies. Instability during the bunch shortening has been studied using a particle-tracking program where the 3D space-charge field due to the beam is calculated with a simplifying model.

  8. Time course of isotonic shortening and the underlying contraction mechanism in airway smooth muscle.

    Syyong, Harley T; Raqeeb, Abdul; Paré, Peter D; Seow, Chun Y


    Although the structure of the contractile unit in smooth muscle is poorly understood, some of the mechanical properties of the muscle suggest that a sliding-filament mechanism, similar to that in striated muscle, is also operative in smooth muscle. To test the applicability of this mechanism to smooth muscle function, we have constructed a mathematical model based on a hypothetical structure of the smooth muscle contractile unit: a side-polar myosin filament sandwiched by actin filaments, each attached to the equivalent of a Z disk. Model prediction of isotonic shortening as a function of time was compared with data from experiments using ovine tracheal smooth muscle. After equilibration and establishment of in situ length, the muscle was stimulated with ACh (100 μM) until force reached a plateau. The muscle was then allowed to shorten isotonically against various loads. From the experimental records, length-force and force-velocity relationships were obtained. Integration of the hyperbolic force-velocity relationship and the linear length-force relationship yielded an exponential function that approximated the time course of isotonic shortening generated by the modeled sliding-filament mechanism. However, to obtain an accurate fit, it was necessary to incorporate a viscoelastic element in series with the sliding-filament mechanism. The results suggest that a large portion of the shortening is due to filament sliding associated with muscle activation and that a small portion is due to continued deformation associated with an element that shows viscoelastic or power-law creep after a step change in force.

  9. Shortening of subjective visual intervals followed by repetitive stimulation.

    Fuminori Ono

    Full Text Available Our previous research demonstrated that repetitive tone stimulation shortened the perceived duration of the preceding auditory time interval. In this study, we examined whether repetitive visual stimulation influences the perception of preceding visual time intervals. Results showed that a time interval followed by a high-frequency visual flicker was perceived as shorter than that followed by a low-frequency visual flicker. The perceived duration decreased as the frequency of the visual flicker increased. The visual flicker presented in one hemifield shortened the apparent time interval in the other hemifield. A final experiment showed that repetitive tone stimulation also shortened the perceived duration of preceding visual time intervals. We concluded that visual flicker shortened the perceived duration of preceding visual time intervals in the same way as repetitive auditory stimulation shortened the subjective duration of preceding tones.

  10. Projectile Velocity and Crater Formation in Water

    Pravitra Chaikulngamdee


    Full Text Available The relationship between the velocity of impact and maximum crater diameter was found for two steel balls dropped into water using 300 fps video. The maximum diameter of the crater was found to be proportional to the impact velocity and independent of the diameter of the ball.

  11. Cirrus Crystal Terminal Velocities.

    Heymsfield, Andrew J.; Iaquinta, Jean


    Cirrus crystal terminal velocities are of primary importance in determining the rate of transport of condensate from upper- to middle-tropospheric levels and profoundly influence the earth's radiation balance through their effect on the rate of buildup or decay of cirrus clouds. In this study, laboratory and field-based cirrus crystal drag coefficient data, as well as analytical descriptions of cirrus crystal shapes, are used to derive more physically based expressions for the velocities of cirrus crystals than have been available in the past.Polycrystals-often bullet rosettes-are shown to be the dominant crystal types in synoptically generated cirrus, with columns present in varying but relatively large percentages, depending on the cloud. The two critical parameters needed to calculate terminal velocity are the drag coefficient and the ratio of mass to cross-sectional area normal to their fall direction. Using measurements and calculations, it is shown that drag coefficients from theory and laboratory studies are applicable to crystals of the types found in cirrus. The ratio of the mass to area, which is shown to be relatively independent of the number of bullets in the rosette, is derived from an analytic model that represents bullet rosettes containing one to eight bullets in 19 primary geometric configurations. The ratio is also derived for columns. Using this information, a general set of equations is developed to calculate the terminal velocities and masses in terms of the aspect ratio (width divided by length), ice density, and rosette maximum dimension. Simple expressions for terminal velocity and mass as a function of bullet rosette maximum dimension are developed by incorporating new information on bullet aspect ratios.The general terminal velocity and mass relations are then applied to a case from the First International Satellite Cloud Climatology Project (ISCCP) Research Experiment (FIRE) 2, when size spectra from a balloon-borne ice crystal

  12. Maximum Autocorrelation Factorial Kriging

    Nielsen, Allan Aasbjerg; Conradsen, Knut; Pedersen, John L.


    This paper describes maximum autocorrelation factor (MAF) analysis, maximum autocorrelation factorial kriging, and its application to irregularly sampled stream sediment geochemical data from South Greenland. Kriged MAF images are compared with kriged images of varimax rotated factors from...

  13. Knowledge and attitudes of dentists toward shortened dental arch ...


    Aug 3, 2015 ... Key words: Attitude, dentist, knowledge, shortened dental arch. Date of Acceptance: ... practice of SDA therapy among dentists in Saudi Arabia, no studies are available in ..... partial denture was similar. Therefore, the attitude ...

  14. Tension and heat production during isometric contractions and shortening in the anterior byssus retractor muscle of Mytilus edulis.

    Gilbert, S H


    1. Tension and heat production were measured during phasic isometric contractions and isovelocity shortening in the anterior byssus retractor muscle (ABRM) of Mytilus edulis at 20 degrees C. 2. Isometric tension at lo was 550 +/- 40 mN/mm2 (S.D. for 173 observations in nine muscles), while the isometric maintenance heat rate was 1.0 +/- 0.2 mW/g wet wt. (S.D. for seventy-eight observations in eight muscles). 3. Isometric tension and heat production were measured as functions of muscle length over a range of 0.79--1.14 lo and were found to bear a linear relation to each other. 4. The force-velocity relation was determined in isovelocity releases imposed during tetanic stimulation and was found to fit the Hill equation with parameters alpha/Po = 0.07 +/- 0.01 and b/lo = 0.016 +/- 0.0007 sec-1 (S.E. from non-linear least-squares regression of the pooled data from seven experiments). 5. Heat production measured in the same experiments showed that shortening heat is produced with a shortening heat coefficient alpha/Po of 0.15. Shortening heat does not appear to be force-dependent, and separate experiments confirmed that it is a linear function of the amount of shortening.

  15. Biochemical response to chronic shortening in unloaded soleus muscles

    Jaspers, S. R.; Fagan, J. M.; Tischler, M. E.


    One leg of tail-casted suspended rats was immobilized in a plantar-flexed position to test whether chronic shortening of posterior leg muscles affected the metabolic response to unloading. The immobilized plantaris and gastrocnemius muscles of these animals showed approximately 20 percent loss of muscle mass in contrast to simply a slower growth rate with unloading. Loss of mass of the soleus muscle during suspension was not accentuated by chronic shortening. Although protein degradation in the isolated soleus muscle of the plantar-flexed limb was slightly faster than in the contralateral free limb, this difference was offset by faster synthesis of the myofibrillar protein fraction of the chronically shortened muscle. Total adenine nucleotides were 17 percent lower (P less than 0.005) in the chronically shortened soleus muscle following incubation. Glutamate, glutamine, and alanine metabolism showed little response to chronic shortening. These results suggest that, in the soleus muscle, chronic shortening did not alter significantly the metabolic responses to unloading and reduced activity.

  16. Consequences of crown shortening canine teeth in Greenland sled dogs

    Kortegaard, H E; Anthony Knudsen, T; Dahl, S


    OBJECTIVES: To evaluate the consequences of crown shortening, focusing on the prevalence of pulp exposure and periapical pathology in Greenland sled dogs that had had their canine crowns shortened at an early age. METHODS: Five cadaver heads and 54 sled dogs underwent an oral examination for dental...... fractures and pulp exposure of canines. All canines were radiographed and evaluated for periapical pathology. RESULTS: The prevalence of canine pulp exposure in 12 (5 heads and 7 dogs) crown shortened dogs was 91 · 7%, and 21 · 3% in 47 not-crown shortened dogs. A significant (P ... exposure of the canines in the crown shortened group compared to the not-crown shortened group was seen with a relative risk of 4 · 3 on a dog basis and a relative risk of 12 · 2 on a tooth basis. In dogs with pulp exposure of canines (n = 51) the prevalence of periapical pathology was 82 · 4%, but only 0...

  17. Effect of Preactivation on Torque Enhancement by the Stretch-Shortening Cycle in Knee Extensors.

    Fukutani, Atsuki; Misaki, Jun; Isaka, Tadao


    The stretch-shortening cycle is one of the most interesting topics in the field of sport sciences, because the performance of human movement is enhanced by the stretch-shortening cycle (eccentric contraction). The purpose of the present study was to examine whether the influence of preactivation on the torque enhancement by stretch-shortening cycle in knee extensors. Twelve men participated in this study. The following three conditions were conducted for knee extensors: (1) concentric contraction without preactivation (CON), (2) concentric contraction with eccentric preactivation (ECC), and (3) concentric contraction with isometric preactivation (ISO). Muscle contractions were evoked by electrical stimulation to discard the influence of neural activity. The range of motion of the knee joint was set from 80 to 140 degrees (full extension = 180 degrees). Angular velocities of the concentric and eccentric contractions were set at 180 and 90 degrees/s, respectively. In the concentric contraction phase, joint torques were recorded at 85, 95, and 105 degrees, and they were compared among the three conditions. In the early phase (85 degrees) of concentric contraction, the joint torque was larger in the ECC and ISO conditions than in the CON condition. However, these clear differences disappeared in the later phase (105 degrees) of concentric contraction. The results showed that joint torque was clearly different among the three conditions in the early phase whereas this difference disappeared in the later phase. Thus, preactivation, which is prominent in the early phase of contractions, plays an important role in torque enhancement by the stretch-shortening cycle in knee extensors.

  18. Effect of Preactivation on Torque Enhancement by the Stretch-Shortening Cycle in Knee Extensors.

    Atsuki Fukutani

    Full Text Available The stretch-shortening cycle is one of the most interesting topics in the field of sport sciences, because the performance of human movement is enhanced by the stretch-shortening cycle (eccentric contraction. The purpose of the present study was to examine whether the influence of preactivation on the torque enhancement by stretch-shortening cycle in knee extensors. Twelve men participated in this study. The following three conditions were conducted for knee extensors: (1 concentric contraction without preactivation (CON, (2 concentric contraction with eccentric preactivation (ECC, and (3 concentric contraction with isometric preactivation (ISO. Muscle contractions were evoked by electrical stimulation to discard the influence of neural activity. The range of motion of the knee joint was set from 80 to 140 degrees (full extension = 180 degrees. Angular velocities of the concentric and eccentric contractions were set at 180 and 90 degrees/s, respectively. In the concentric contraction phase, joint torques were recorded at 85, 95, and 105 degrees, and they were compared among the three conditions. In the early phase (85 degrees of concentric contraction, the joint torque was larger in the ECC and ISO conditions than in the CON condition. However, these clear differences disappeared in the later phase (105 degrees of concentric contraction. The results showed that joint torque was clearly different among the three conditions in the early phase whereas this difference disappeared in the later phase. Thus, preactivation, which is prominent in the early phase of contractions, plays an important role in torque enhancement by the stretch-shortening cycle in knee extensors.

  19. Velocity Measurement Based on Laser Doppler Effect

    ZHANG Yan-Yan; HUO Yu-Jing; HE Shu-Fang; GONG Ke


    @@ A novel method for velocity measurement is presented.In this scheme,a parallel-linear-polarization dualfrequency laser is incident on the target and senses the target velocity with both the frequencies,which can increase the maximum measurable velocity significantly.The theoretical analysis and verification experiment of the novel method are presented,which show that high-velocity measurement can be achieved with high precision using this method.

  20. Ultrasonic investigation of the effect of vegetable shortening and mixing time on the mechanical properties of bread dough.

    Mehta, K L; Scanlon, M G; Sapirstein, H D; Page, J H


    Mixing is a critical stage in breadmaking since it controls gluten development and nucleation of gas bubbles in the dough. Bubbles affect the rheology of the dough and largely govern the quality of the final product. This study used ultrasound (at a frequency where it is sensitive to the presence of bubbles) to nondestructively examine dough properties as a function of mixing time in doughs prepared from strong red spring wheat flour with various amounts of shortening (0%, 2%, 4%, 8% flour weight basis). The doughs were mixed for various times at atmospheric pressure or under vacuum (to minimize bubble nucleation). Ultrasonic velocity and attenuation (nominally at 50 kHz) were measured in the dough, and dough density was measured independently from specific gravity determinations. Ultrasonic velocity decreased substantially as mixing time increased (and more bubbles were entrained) for all doughs mixed in air; for example, in doughs made without shortening, velocity decreased from 165 to 105 ms(-1), although superimposed on this overall decrease was a peak in velocity at optimum mixing time. Changes in attenuation coefficient due to the addition of shortening were evident in both air-mixed and vacuum-mixed doughs, suggesting that ultrasound was sensitive to changes in the properties of the dough matrix during dough development and to plasticization of the gluten polymers by the shortening. Due to its ability to probe the effect of mixing times and ingredients on dough properties, ultrasound has the potential to be deployed as an online quality control tool in the baking industry.

  1. Frying performance of palm-based solid frying shortening.

    Omar, M N; Nor-Nazuha, M N; Nor-Dalilah, M N; Sahri, M M


    In order to evaluate the frying performance of palm-based solid frying shortening against standard olein, the fresh potato chips were fried in both frying media using an open fryer. After frying the chips for 40 h in an open batch fryer, it was found that the frying quality of palm-based solid frying shortening was better than standard palm olein in terms of Free Fatty Acid (FFA) values, Total Polar Content (TPC) and Total Polymeric Material (TPM). Solid shortening gave FFA, TPC and TPM values of 0.7, 15.3 and 2.67%, respectively, whilst standard palm olein gave values for FFA, TPC and TPM of 1.2, 19.6 and 3.10%, respectively. In terms of sensory mean scores, sensory panelists preferred the color of potato chips fried in solid shortening on the first day of frying, while on the third and fifth day of frying there were no significant differences (p palm olein when used for deep fat frying in terms of FFA values, total polar content and total polymeric material, especially for starch-based products such as potato chips. The result also shows that, in terms of sensory mean scores, after frying for 40 h, the sensory panelists gave higher scores in terms of taste, flavor and crispiness for potato chips fried in palm-based solid shortening.

  2. Trans Fatty Acid content in Danish margarines and shortenings

    Leth, Torben; Bysted, Anette; Hansen, Kirsten


    in shortenings, averaging about 6-7%. Long-chain TFA from hydrogenated,fish oil, although present in 13 brands in 1995, were not found at all in the 1999 samples. Trans-linoleic acids or CLA were not found. The reduction in TFA content in margarines has not resulted in a systematic change over the years......Margarines and shortenings have been major contributors to the intake by humans of the probably atherogenic trans FA (TFA). In 1999, all 73 brands of margarines and shortenings on the Danish market were analyzed by GLC on a 50-m highly polar capillary column, and the results were compared...... in the content of saturated FA, monounsaturated FA, or PUFA. Calculated from sales figures, the intake of TFA decreased from 2.2 g per capita per year in 1992, to 1.5 g in 1995, and to 0.4 g in, 1999....

  3. Unloaded speed of shortening in voltage-clamped intact skeletal muscle fibers from wt, mdx, and transgenic minidystrophin mice using a novel high-speed acquisition system.

    Friedrich, O; Weber, C; von Wegner, F; Chamberlain, J S; Fink, R H A


    Skeletal muscle unloaded shortening has been indirectly determined in the past. Here, we present a novel high-speed optical tracking technique that allows recording of unloaded shortening in single intact, voltage-clamped mammalian skeletal muscle fibers with 2-ms time resolution. L-type Ca(2+) currents were simultaneously recorded. The time course of shortening was biexponential: a fast initial phase, tau(1), and a slower successive phase, tau(2,) with activation energies of 59 kJ/mol and 47 kJ/mol. Maximum unloaded shortening speed, v(u,max), was faster than that derived using other techniques, e.g., approximately 14.0 L(0) s(-1) at 30 degrees C. Our technique also allowed direct determination of shortening acceleration. We applied our technique to single fibers from C57 wild-type, dystrophic mdx, and minidystrophin-expressing mice to test whether unloaded shortening was affected in the pathophysiological mechanism of Duchenne muscular dystrophy. v(u,max) and a(u,max) values were not significantly different in the three strains, whereas tau(1) and tau(2) were increased in mdx fibers. The results were complemented by myosin heavy and light chain (MLC) determinations that showed the same myosin heavy chain IIA profiles in the interossei muscles from the different strains. In mdx muscle, MLC-1f was significantly increased and MLC-2f and MLC-3f somewhat reduced. Fast initial active shortening seems almost unaffected in mdx muscle.

  4. Maximum Autocorrelation Factorial Kriging

    Nielsen, Allan Aasbjerg; Conradsen, Knut; Pedersen, John L.; Steenfelt, Agnete


    This paper describes maximum autocorrelation factor (MAF) analysis, maximum autocorrelation factorial kriging, and its application to irregularly sampled stream sediment geochemical data from South Greenland. Kriged MAF images are compared with kriged images of varimax rotated factors from an ordinary non-spatial factor analysis, and they are interpreted in a geological context. It is demonstrated that MAF analysis contrary to ordinary non-spatial factor analysis gives an objective discrimina...

  5. Challenges in Shortening New Product Introduction in the Pharmaceutical Industry

    Hansen, Klaus Reinholdt Nyhuus; Grunow, Martin


    Drug developing companies are forced to utilize the effective protection of the patent by focusing on shortening the new product introduction [NPI] process measured as Time-to-Market [TTM]. Here the NPI process is considered and the trade-offs, which have to be address in the future are identifie...

  6. Telomere shortening reduces Alzheimer's disease amyloid pathology in mice

    Rolyan, Harshvardhan; Scheffold, Annika; Heinrich, Annette; Begus-Nahrmann, Yvonne; Langkopf, Britta Heike; Hoelter, Sabine M.; Vogt-Weisenhorn, Daniela M.; Liss, Birgit; Wurst, Wolfgang; Lie, Dieter Chichung; Thal, Dietmar Rudolf; Biber, Knut; Rudolph, Karl Lenhard

    Alzheimer's disease is a neurodegenerative disorder of the elderly and advancing age is the major risk factor for Alzheimer's disease development. Telomere shortening represents one of the molecular causes of ageing that limits the proliferative capacity of cells, including neural stem cells.

  7. A technique for nailing severely shortened and displaced tibia fractures.

    Krause, Peter C; Whatley, Adam N; Mautner, James F


    Previously described techniques using external fixators or large distractors can simplify the closed nailing of tibia fractures and nonunions. However, delayed intramedullary nailing can be especially challenging when significant shortening or translation has occurred. We present a modification of an old technique for external fixator-assisted closed tibial nailing in these difficult cases.

  8. Cellular Consequences of Telomere Shortening in Histologically Normal Breast Tissues


    in Figure 1, telomere shortening occurs specifically in luminal epithelial cells, but not in myoepithelial cells, in histologically normal terminal...the adjacent myoepithelial cells (panel A). In contrast, some TDLUs demonstrate dim telomere signals in the luminal cells when compared to the...adjacent myoepithelial cells (panel B). Through digital image analysis, quantitative determination of the telomere FISH signals confirms this moderated

  9. Telomere shortening reduces Alzheimer's disease amyloid pathology in mice

    Rolyan, Harshvardhan; Scheffold, Annika; Heinrich, Annette; Begus-Nahrmann, Yvonne; Langkopf, Britta Heike; Hoelter, Sabine M.; Vogt-Weisenhorn, Daniela M.; Liss, Birgit; Wurst, Wolfgang; Lie, Dieter Chichung; Thal, Dietmar Rudolf; Biber, Knut; Rudolph, Karl Lenhard


    Alzheimer's disease is a neurodegenerative disorder of the elderly and advancing age is the major risk factor for Alzheimer's disease development. Telomere shortening represents one of the molecular causes of ageing that limits the proliferative capacity of cells, including neural stem cells. Studie

  10. Residual force enhancement following shortening is speed-dependent

    Fortuna, Rafael; Power, Geoffrey A.; Mende, Esther; Seiberl, Wolfgang; Herzog, Walter


    The steady-state isometric force following active muscle shortening or lengthening is smaller (force depression; FD) or greater (residual force enhancement; RFE) than a purely isometric contraction at the corresponding length. The mechanisms underlying these phenomena are not explained within the context of the cross-bridge theory and are rarely studied in concert. Previous studies have shown RFE to be speed-independent. In the present study, we investigated if RFE preceded by active shortening is time-dependent by electrically evoking RFE in the human adductor pollicis muscle. The results shown that a slow stretch following FD fully re-established RFE compared to higher speeds of stretch. The mechanism(s) responsible for the recovery of RFE following a preceding shortening contraction (FD) might be associated with the recovery of cross-bridge based force and/or the re-engagement of a passive structural element (titin). Voluntary interaction with one’s environment involves highly coordinated shortening and lengthening muscle contractions. Therefore comprehending these history-dependent muscle properties in the context of movement control is paramount in understanding the behavior of in vivo motor control. PMID:26869508

  11. Telomere shortening may be associated with human keloids

    Wilson Robert R


    Full Text Available Abstract Background Keloids are benign skin tumors that are the effect of a dysregulated wound-healing process in genetically predisposed patients. They are inherited with an autosomal dominant mode with incomplete clinical penetrance and variable expression. Keloids are characterized by formation of excess scar tissue beyond the boundaries of the wound. The exact etiology is still unknown and there is currently no appropriate treatment for keloid disease. Methods We analyzed sample tissues were obtained from 20 patients with keloid skin lesions and normal skin was obtained from 20 healthy donors. The telomeres were measured by Terminal Restriction Fragment (TRF analysis and Real-Time PCR assay. Quantitative Real-Time RT-PCR analysis of hTERT gene expression was performed and intracellular ROS generation was measured. Results In this study, we determined whether telomeric shortening and the expression of human telomerase reverse transcriptase (hTERT occurs in keloid patients. Using Terminal Restriction Fragment (TRF analysis and Real-Time PCR assay, we detected a significant telomere shortening of 30% in keloid specimens compared to normal skin. Using quantitative Real-Time RT-PCR, telomerase activity was found absent in the keloid tissues. Moreover, an increase in ROS generation was detected in fibroblasts cell cultures from keloid specimens as more time elapsed compared to fibroblasts from normal skin. Conclusion Telomere shortening has been reported in several metabolic and cardiovascular diseases. We found that telomere shortening can also be associated with human keloids. Chronic oxidative stress plays a major role in the pathophysiology of several chronic inflammatory diseases. Here we found increased ROS generation in fibroblasts from keloid fibroblasts cell cultures when compared to normal skin fibroblasts. Hence we conclude that oxidative stress might be an important modulator of telomere loss in keloid because of the absence of active

  12. Impaired neuromuscular function during isometric, shortening, and lengthening contractions after exercise-induced damage to elbow flexor muscles.

    Turner, Tanya S; Tucker, Kylie J; Rogasch, Nigel C; Semmler, John G


    The purpose of this study was to examine the effect of exercise-induced damage of the elbow flexor muscles on steady motor performance during isometric, shortening, and lengthening contractions. Ten healthy individuals (age 22+/-4 yr) performed four tasks with the elbow flexor muscles: a maximum voluntary contraction, a one repetition maximum (1 RM), an isometric task at three joint angles (short, intermediate, and long muscle lengths), and a constant-load task during slow (approximately 7 degrees/s) shortening and lengthening contractions. Task performance was quantified as the fluctuations in wrist acceleration (steadiness), and electromyography was obtained from the biceps and triceps brachii muscles at loads of 10, 20, and 40% of 1 RM. Tasks were performed before, immediately after, and 24 h after eccentric exercise that resulted in indicators of muscle damage. Maximum voluntary contraction force and 1-RM load declined by approximately 45% immediately after exercise and remained lower at 24 h ( approximately 30% decrease). Eccentric exercise resulted in reduced steadiness and increased biceps and triceps brachii electromyography for all tasks. For the isometric task, steadiness was impaired at the short compared with the long muscle length immediately after exercise (Pshortening compared with the lengthening contractions after exercise (P=0.01), and steadiness remained impaired for shortening contractions 24 h later (P=0.01). These findings suggest that there are profound effects for the performance of these types of fine motor tasks when recovering from a bout of eccentric exercise.

  13. Force-velocity, force-power relationships of bilateral and unilateral leg multi-joint movements in young and elderly women.

    Yamauchi, Junichiro; Mishima, Chizuko; Nakayama, Satoshi; Ishii, Naokata


    The present study investigated force-velocity and force-power relationships of bilateral and unilateral knee-hip extension movement in young and elderly women. Twelve healthy young (age, 19-31 yr) and 12 healthy elderly (age, 60-82 yr) women performed bilateral and unilateral knee-hip extension movements on the dynamometer against loads controlled by the servo system. Under the isotonic force condition, force-velocity relationships were measured. The maximum isometric force (F(max)), unloaded velocity (V(max)) and power output (P(max)) of the movements were calculated from extrapolating force-velocity and force-power relationships. F(max) and P(max) of bilateral and unilateral knee-hip extension movements were 20-30% lower in elderly than in young women. On the other hand, there were no significant differences in V(max) between young and elderly women and between bilateral and unilateral movements. Bilateral deficit was larger as the generation of force was larger in both young and elderly women. Also, bilateral deficit of F(max) and P(max) were not different between young and elderly women. The results were that lower maximum power output of bilateral and unilateral leg multi-joint movements in elderly women did not depend on the intrinsic shortening velocity of muscle action, but largely on reduction in force generating capacity. This suggests the importance of preventing a loss of force generating capacity of muscles during leg multi-joint movements in elderly women.

  14. Exhumation and shortening distribution in the Taiwan orogen: insights from thermomechanical modeling

    Mouthereau, F.; Yamato, P.; Burov, E.


    The Taiwan orogen has long been regarded as a case example for studying exhumation and erosion processes in association with mountain building. In the recent years, the increasing number of thermochronometric data (mainly ZFT and AFT ages) has allowed to better understanding the deep-seated tectonic processes. For instance, using thermomechanical wedge modelling, up to 50% of underplating has been proposed to explain the observed distribution of FT ages. So it would appear that a large amount of materials added to the orogen originated in more deeper and ductile parts of the crust. The nature of this additional flux (velocity, mechanism of deformation) is however poorly constrained in the current thermomechanical model. Our concern is to use a fully- coupled visco-elasto-plastic themomechanical numerical model to reproduce the observed FT ages and long- term distribution of shortening. To this aim we use the numerical code PARA(O)VOZ based on F.L.A.C. (Fast Lagrangian Analysis of Continua) algorithm. Our results show that the particular distribution of shortening across the Taiwan belt as well as the rapid exhumation and thermal conditions in the hinterland are well accounted for by two superimposed flows of upper and lower crustal rocks decoupled from the subducting Eurasian mantle.

  15. Comparison of the tension responses to ramp shortening and lengthening in intact mammalian muscle fibres: crossbridge and non-crossbridge contributions.

    Roots, H; Offer, G W; Ranatunga, K W


    We examined the tension responses to ramp shortening and lengthening over a range of velocities (0.1-5 L(0)/s) and at 20 degrees C and 30 degrees C in tetanized intact fibre bundles from a rat fast (flexor hallucis brevis) muscle; fibre length (L(0)) was 2.2 mm and sarcomere length approximately 2.5 microm. The tension change during ramp releases as well as ramp stretches showed an early transition (often appearing as an inflection) at 1-4 ms; the tension change at this transition and the length change at which it occurred increased with velocity. A second transition, indicated by a more gradual reduction in slope, occurred when the length had changed by 14-28 nm per half-sarcomere; the tension at this transition increased with lengthening velocity towards a plateau and it decreased with shortening velocity towards zero tension. The velocity dependence of the time to the transitions and the length change at the transitions showed some asymmetries between shortening and lengthening. Based on analyses of the velocity dependence of the tension and modelling, we propose that the first transition reflects the tension change associated with the crossbridge power stroke in shortening, or with the reversal of the power stroke in lengthening. Modelling shows that the reduction in slope at the second transition occurs when most of the crossbridges (myosin heads) that were attached at the start of the ramp become detached. After the second transition, the tension reaches a steady level in the model whereas the tension continues to increase during lengthening and continues to decrease during shortening in the experiments; this continuous tension change is seen at a wide range of initial sarcomere lengths and when active force is reduced by the myosin inhibitor, BTS. The continuous tension decline during shortening is not abolished by caffeine, but the rate of decline is reduced when the active force is depressed by BTS. We propose that stiffening of non-crossbridge visco

  16. Maximum likely scale estimation

    Loog, Marco; Pedersen, Kim Steenstrup; Markussen, Bo


    A maximum likelihood local scale estimation principle is presented. An actual implementation of the estimation principle uses second order moments of multiple measurements at a fixed location in the image. These measurements consist of Gaussian derivatives possibly taken at several scales and/or ...

  17. Methods for Shortening and Extending the Carbon Chain in Carbohydrates

    Monrad, Rune Nygaard


    Carbohydrates play a central role in a variety of physiological and pathological processes such as HIV, cancer and diabetes. The understanding of these processes and the development of specific therapeutic agents is relying on the ability to chemically synthesize unnatural sugars, glycoconjugates...... and carbohydrate mimetics. Such polyhydroxylated compounds are conveniently synthesized from carbohydrates, however, due to the scarcity of many sugars from nature, efficient methods for transformation of readily available carbohydrates into valuable chiral building blocks are required. The work presented...... in this thesis focuses on the development and application of transition metal mediated methods for shortening and extending the carbon chain in carbohydrates thereby providing access to lower and higher sugars.A new catalytic procedure for shortening unprotected sugars by one carbon atom has been developed...

  18. The maximum rotation of a galactic disc

    Bottema, R


    The observed stellar velocity dispersions of galactic discs show that the maximum rotation of a disc is on average 63% of the observed maximum rotation. This criterion can, however, not be applied to small or low surface brightness (LSB) galaxies because such systems show, in general, a continuously rising rotation curve until the outermost measured radial position. That is why a general relation has been derived, giving the maximum rotation for a disc depending on the luminosity, surface brightness, and colour of the disc. As a physical basis of this relation serves an adopted fixed mass-to-light ratio as a function of colour. That functionality is consistent with results from population synthesis models and its absolute value is determined from the observed stellar velocity dispersions. The derived maximum disc rotation is compared with a number of observed maximum rotations, clearly demonstrating the need for appreciable amounts of dark matter in the disc region and even more so for LSB galaxies. Matters h...

  19. Meat toughening does not occur when rigor shortening is prevented.

    Koohmaraie, M; Doumit, M E; Wheeler, T L


    The objective of this experiment was to test the hypothesis that meat toughening during the first 24 h postmortem results from sarcomere shortening during rigor mortis development. Eleven market-weight lambs were used to measure changes in shear force of clamped longissimus during rigor development. Within 15 min of exsanguination, while attached at both ends, each longissimus was separated from the vertebrae body and clamped between three sets of metal plates to prevent muscle shortening (six clamped sections per lamb). Five of the clamped sections were placed at -1.1 degrees C for 0, 3, 6, 12, or 24 h. After storage at their respective times at -1.1 degrees C, the samples were placed at -30 degrees C for 90 min and then at -5 degrees C for 8 d. The sixth section (168-h section) was stored at -1.1 degrees C for the first 24 h, at 4 degrees C for 144 h, and then treated the same as other sampling times. Sections were sampled for pH, sarcomere length, shear force, and Western blot analyses before and after storage at -5 degrees C. Shear force values were the same (P > .05) from 0 to 24 h (4.5 kg at 0 h to 4.9 kg at 24 h) then declined (P slaughter is most likely due to sarcomere shortening.

  20. Maximum information photoelectron metrology

    Hockett, P; Wollenhaupt, M; Baumert, T


    Photoelectron interferograms, manifested in photoelectron angular distributions (PADs), are a high-information, coherent observable. In order to obtain the maximum information from angle-resolved photoionization experiments it is desirable to record the full, 3D, photoelectron momentum distribution. Here we apply tomographic reconstruction techniques to obtain such 3D distributions from multiphoton ionization of potassium atoms, and fully analyse the energy and angular content of the 3D data. The PADs obtained as a function of energy indicate good agreement with previous 2D data and detailed analysis [Hockett et. al., Phys. Rev. Lett. 112, 223001 (2014)] over the main spectral features, but also indicate unexpected symmetry-breaking in certain regions of momentum space, thus revealing additional continuum interferences which cannot otherwise be observed. These observations reflect the presence of additional ionization pathways and, most generally, illustrate the power of maximum information measurements of th...

  1. The Prediction of Maximum Amplitudes of Solar Cycles and the Maximum Amplitude of Solar Cycle 24


    We present a brief review of predictions of solar cycle maximum ampli-tude with a lead time of 2 years or more. It is pointed out that a precise predictionof the maximum amplitude with such a lead-time is still an open question despiteprogress made since the 1960s. A method of prediction using statistical character-istics of solar cycles is developed: the solar cycles are divided into two groups, ahigh rising velocity (HRV) group and a low rising velocity (LRV) group, dependingon the rising velocity in the ascending phase for a given duration of the ascendingphase. The amplitude of Solar Cycle 24 can be predicted after the start of thecycle using the formula derived in this paper. Now, about 5 years before the startof the cycle, we can make a preliminary prediction of 83.2-119.4 for its maximumamplitude.

  2. A Posteriori Equivalence: A New Perspective for Design of Optimal Channel Shortening Equalizers

    Venkataramani, Raman


    The problem of channel shortening equalization for optimal detection in ISI channels is considered. The problem is to choose a linear equalizer and a partial response target filter such that the combination produces the best detection performance. Instead of using the traditional approach of MMSE equalization, we directly seek all equalizer and target pairs that yield optimal detection performance in terms of the sequence or symbol error rate. This leads to a new notion of a posteriori equivalence between the equalized and target channels with a simple characterization in terms of their underlying probability distributions. Using this characterization we show the surprising existence an infinite family of equalizer and target pairs for which any maximum a posteriori (MAP) based detector designed for the target channel is simultaneously MAP optimal for the equalized channel. For channels whose input symbols have equal energy, such as q-PSK, the MMSE equalizer designed with a monic target constraint yields a so...

  3. Maximum Likelihood Associative Memories

    Gripon, Vincent; Rabbat, Michael


    Associative memories are structures that store data in such a way that it can later be retrieved given only a part of its content -- a sort-of error/erasure-resilience property. They are used in applications ranging from caches and memory management in CPUs to database engines. In this work we study associative memories built on the maximum likelihood principle. We derive minimum residual error rates when the data stored comes from a uniform binary source. Second, we determine the minimum amo...

  4. Maximum likely scale estimation

    Loog, Marco; Pedersen, Kim Steenstrup; Markussen, Bo


    A maximum likelihood local scale estimation principle is presented. An actual implementation of the estimation principle uses second order moments of multiple measurements at a fixed location in the image. These measurements consist of Gaussian derivatives possibly taken at several scales and....../or having different derivative orders. Although the principle is applicable to a wide variety of image models, the main focus here is on the Brownian model and its use for scale selection in natural images. Furthermore, in the examples provided, the simplifying assumption is made that the behavior...... of the measurements is completely characterized by all moments up to second order....

  5. Isolated lunotriquetral ligament tears treated with ulnar shortening osteotomy.

    Mirza, Ather; Mirza, Justin B; Shin, Alexander Y; Lorenzana, Daniel J; Lee, Brian K; Izzo, Brett


    To evaluate outcomes in a single-surgeon series of ulnar shortening osteotomy for the treatment of traumatic isolated tears to the lunotriquetral interosseous ligament (LTIL). This study includes 53 consecutive cases of posttraumatic isolated LTIL tears treated with ulnar shortening osteotomy with minimum 1-year follow-up (range, 1.0-10.6 y). We confirmed all LTIL tears via arthroscopy before performing a precision 2.5-mm oblique osteotomy using a modified Rayhack technique. We assessed outcomes using grip strength measurements and Chun and Palmer's modified Gartland Werley wrist scoring system, which includes subjective and objective outcome measures. Preoperatively, 45 cases were graded as fair (28%; n = 15) or poor (57%; n = 30) on the modified Gartland Werley score. There were insufficient data to calculate grades in 8 cases (15%). At final follow-up, most patients exhibited excellent (51%; n = 27) or good (32%; n = 17) scores, some scored fair (17%; n = 9), and none scored as poor. All subjective and objective variables significantly improved over a mean follow-up of 36 months (range, 12-127 mo). Mean grip strength increased from a value of 23 kg before surgery to 33 kg over the same period, a 41% increase. All patients achieved clinical and radiographic union by 10 months. Osteotomy plates were removed routinely in most cases (89%; n = 47) at a mean of 17 months. Ulnar shortening osteotomy reduced symptoms of posttraumatic isolated LTIL tears in this single-surgeon series. Therapeutic IV. Copyright © 2013 American Society for Surgery of the Hand. Published by Elsevier Inc. All rights reserved.

  6. Guidelines for reconstructing the metatarsal parabola with the shortening osteotomy.

    Valley, B A; Reese, H W


    Lesser metatarsal pathology is difficult to treat surgically. The shortening osteotomy has shown promise as a useful technique. The following objectives are addressed in this study: 1) to discuss present techniques and two new radiographic measurement systems; 2) to establish mean, standard deviation, and normal range values for these measurement systems; 3) to determine if these measurements vary with foot size; and 4) to use the results to establish general guidelines for metatarsal parabola reconstruction. Means and normal ranges for the various radiographic measurements are identified to help the surgeon with preoperative evaluation and planning. The measurements vary mildly with foot size.

  7. Velocity anticipation in the optimal velocity model

    DONG Li-yun; WENG Xu-dan; LI Qing-ding


    In this paper,the velocity anticipation in the optimal velocity model (OVM) is investigated.The driver adjusts the velocity of his vehicle by the desired headway,which depends on both instantaneous headway and relative velocity.The effect of relative velocity is measured by a sensitivity function.A specific form of the sensitivity function is supposed and the involved parameters are determined by the both numerical simulation and empirical data.It is shown that inclusion of velocity anticipation enhances the stability of traffic flow.Numerical simulations show a good agreement with empirical data.This model provides a better description of real traffic,including the acceleration process from standing states and the deceleration process approaching a stopped car.

  8. Maximum Entropy Fundamentals

    F. Topsøe


    Full Text Available Abstract: In its modern formulation, the Maximum Entropy Principle was promoted by E.T. Jaynes, starting in the mid-fifties. The principle dictates that one should look for a distribution, consistent with available information, which maximizes the entropy. However, this principle focuses only on distributions and it appears advantageous to bring information theoretical thinking more prominently into play by also focusing on the "observer" and on coding. This view was brought forward by the second named author in the late seventies and is the view we will follow-up on here. It leads to the consideration of a certain game, the Code Length Game and, via standard game theoretical thinking, to a principle of Game Theoretical Equilibrium. This principle is more basic than the Maximum Entropy Principle in the sense that the search for one type of optimal strategies in the Code Length Game translates directly into the search for distributions with maximum entropy. In the present paper we offer a self-contained and comprehensive treatment of fundamentals of both principles mentioned, based on a study of the Code Length Game. Though new concepts and results are presented, the reading should be instructional and accessible to a rather wide audience, at least if certain mathematical details are left aside at a rst reading. The most frequently studied instance of entropy maximization pertains to the Mean Energy Model which involves a moment constraint related to a given function, here taken to represent "energy". This type of application is very well known from the literature with hundreds of applications pertaining to several different elds and will also here serve as important illustration of the theory. But our approach reaches further, especially regarding the study of continuity properties of the entropy function, and this leads to new results which allow a discussion of models with so-called entropy loss. These results have tempted us to speculate over

  9. Regularized maximum correntropy machine

    Wang, Jim Jing-Yan


    In this paper we investigate the usage of regularized correntropy framework for learning of classifiers from noisy labels. The class label predictors learned by minimizing transitional loss functions are sensitive to the noisy and outlying labels of training samples, because the transitional loss functions are equally applied to all the samples. To solve this problem, we propose to learn the class label predictors by maximizing the correntropy between the predicted labels and the true labels of the training samples, under the regularized Maximum Correntropy Criteria (MCC) framework. Moreover, we regularize the predictor parameter to control the complexity of the predictor. The learning problem is formulated by an objective function considering the parameter regularization and MCC simultaneously. By optimizing the objective function alternately, we develop a novel predictor learning algorithm. The experiments on two challenging pattern classification tasks show that it significantly outperforms the machines with transitional loss functions.

  10. The role of nonlinear viscoelasticity on the functionality of laminating shortenings

    Macias-Rodriguez, Braulio A.; Peyronel, Fernanda; Marangoni, Alejandro G.


    The rheology of fats is essential for the development of homogeneous and continuous layered structures of doughs. Here, we define laminating shortenings in terms of rheological behavior displayed during linear-to-nonlinear shear deformations, investigated by large amplitude oscillatory shear rheology. Likewise, we associate the rheological behavior of the shortenings with structural length scales elucidated by ultra-small angle x-ray scattering and cryo-electron microscopy. Shortenings exhibited solid-like viscoelastic and viscoelastoplastic behaviors in the linear and nonlinear regimes respectively. In the nonlinear region, laminating shortenings dissipated more viscous energy (larger normalized dynamic viscosities) than a cake bakery shortening. The fat solid-like network of laminating shortening displayed a three-hierarchy structure and layered crystal aggregates, in comparison to two-hierarchy structure and spherical-like crystal aggregates of a cake shortening. We argue that the observed rheology, correlated to the structural network, is crucial for optimal laminating performance of shortenings.


    WANG Dianchang; WANG Xingkui; YU Mingzhong; LI Danxun


    The log-law and the wake law of velocity profile for open channel flows are discussed and compared in this paper. Experimental data from eight sources are used to verify the velocity distribution models.The effect of bed level on the velocity profile is analyzed. A formula to calculate the maximum velocity is proposed. In the region of y <δm , the velocity profile approximately follows the log-law. For the region of y >δm , the effect of the aspect ratio is considered. A new velocity profile model on the basis of log-law that can unify all of the hydraulic bed roughness is presented.

  12. Local wavefield velocity imaging for damage evaluation

    Chia, Chen Ciang; Gan, Chia Sheng; Mustapha, F.


    Ultrasonic Propagation Imaging or Acoustic Wavefield Imaging has been widely used to evaluate structural damages and internal features. Inspecting complete wavefield time history for damage identification is tedious and error-prone. A more effective way is by extracting damage-related information into a single image. A wavefield velocity imaging method that maps the local estimates of group or phase velocity is proposed. Actual velocity values rather than arbitrarily-scaled intensities are mapped, enabling damage sizing without the need of supervised training or inspecting wavefield propagation video. Performance of the proposed method was tested by inspecting a 100 mm by 100 mm area of a 2 mm thick stainless steel specimen. Local phase velocity maps of A0 mode showed a half-thickness hole of 2 mm diameter as significant change in local phase velocity from the nominal 2 m/ms. Full width at half maximum of relevant velocity profiles proved the accuracy and consistency of the damage sizing.

  13. Foot lengthening and shortening during gait: a parameter to investigate foot function?

    Stolwijk, N M; Koenraadt, K L M; Louwerens, J W K; Grim, D; Duysens, J; Keijsers, N L W


    Based on the windlass mechanism theory of Hicks, the medial longitudinal arch (MLA) flattens during weight bearing. Simultaneously, foot lengthening is expected. However, changes in foot length during gait and the influence of walking speed has not been investigated yet. The foot length and MLA angle of 34 healthy subjects (18 males, 16 females) at 3 velocities (preferred, low (preferred -0.4 m/s) and fast (preferred +0.4 m/s) speed were investigated with a 3D motion analysis system (VICON(®)). The MLA angle was calculated as the angle between the second metatarsal head, the navicular tuberculum and the heel in the local sagittal plane. Foot length was calculated as the distance between the marker at the heel and the 2nd metatarsal head. A General Linear Model for repeated measures was used to indicate significant differences in MLA angle and foot length between different walking speeds. The foot lengthened during the weight acceptance phase of gait and shortened during propulsion. With increased walking speed, the foot elongated less after heel strike and shortened more during push off. The MLA angle and foot length curve were similar, except between 50% and 80% of the stance phase in which the MLA increases whereas the foot length showed a slight decrease. Foot length seems to represent the Hicks mechanism in the foot and the ability of the foot to bear weight. At higher speeds, the foot becomes relatively stiffer, presumably to act as a lever arm to provide extra propulsion. Copyright © 2013 Elsevier B.V. All rights reserved.

  14. Simulation studies of circular muscle contraction, longitudinal muscle shortening, and their coordination in esophageal transport.

    Kou, Wenjun; Pandolfino, John E; Kahrilas, Peter J; Patankar, Neelesh A


    On the basis of a fully coupled active musculomechanical model for esophageal transport, we aimed to find the roles of circular muscle (CM) contraction and longitudinal muscle (LM) shortening in esophageal transport, and the influence of their coordination. Two groups of studies were conducted using a computational model. In the first group, bolus transport with only CM contraction, only LM shortening, or both was simulated. Overall features and detailed information on pressure and the cross-sectional area (CSA) of mucosal and the two muscle layers were analyzed. In the second group, bolus transport with varying delay in CM contraction or LM shortening was simulated. The effect of delay on esophageal transport was studied. For cases showing abnormal transport, pressure and CSA were further analyzed. CM contraction by itself was sufficient to transport bolus, but LM shortening by itself was not. CM contraction decreased the CSA and the radius of the muscle layer locally, but LM shortening increased the CSA. Synchronized CM contraction and LM shortening led to overlapping of muscle CSA and pressure peaks. Advancing LM shortening adversely influenced bolus transport, whereas lagging LM shortening was irrelevant to bolus transport. In conclusion, CM contraction generates high squeezing pressure, which plays a primary role in esophageal transport. LM shortening increases muscle CSA, which helps to strengthen CM contraction. Advancing LM shortening decreases esophageal distensibility in the bolus region. Lagging LM shortening no longer helps esophageal transport. Synchronized CM contraction and LM shortening seems to be most effective for esophageal transport.

  15. Equalized near maximum likelihood detector


    This paper presents new detector that is used to mitigate intersymbol interference introduced by bandlimited channels. This detector is named equalized near maximum likelihood detector which combines nonlinear equalizer and near maximum likelihood detector. Simulation results show that the performance of equalized near maximum likelihood detector is better than the performance of nonlinear equalizer but worse than near maximum likelihood detector.

  16. Generalized Maximum Entropy

    Cheeseman, Peter; Stutz, John


    A long standing mystery in using Maximum Entropy (MaxEnt) is how to deal with constraints whose values are uncertain. This situation arises when constraint values are estimated from data, because of finite sample sizes. One approach to this problem, advocated by E.T. Jaynes [1], is to ignore this uncertainty, and treat the empirically observed values as exact. We refer to this as the classic MaxEnt approach. Classic MaxEnt gives point probabilities (subject to the given constraints), rather than probability densities. We develop an alternative approach that assumes that the uncertain constraint values are represented by a probability density {e.g: a Gaussian), and this uncertainty yields a MaxEnt posterior probability density. That is, the classic MaxEnt point probabilities are regarded as a multidimensional function of the given constraint values, and uncertainty on these values is transmitted through the MaxEnt function to give uncertainty over the MaXEnt probabilities. We illustrate this approach by explicitly calculating the generalized MaxEnt density for a simple but common case, then show how this can be extended numerically to the general case. This paper expands the generalized MaxEnt concept introduced in a previous paper [3].

  17. X-ray interference studies of crossbridge action in muscle contraction: evidence from muscles during steady shortening.

    Huxley, Hugh; Reconditi, Massimo; Stewart, Alex; Irving, Tom


    During normal muscle shortening, the myosin heads must undergo many cycles of interaction with the actin filaments sliding past them. It is important to determine what range of configurations is found under these circumstances, and, in terms of the tilting lever arm model, what range of orientations the lever arms undergo. We have studied this using the X-ray interference technique described in the previous article, focusing mainly on the changes in the first order meridional reflection (M3) as compared to isometric. The change in ratio of the heights of the interference peaks indicates how far the mean lever arm angle has moved towards the end of the working stroke; the total intensity change depends on the angle change, on the number of heads now attached at any one time, and on the dispersion of lever arm angles. The latter provides a measure of the distance over which myosin heads remain attached to actin as they go through their working strokes. Surprisingly, the mean position of the attached heads moves only about 1 nm inwards (towards the center of the A-band) at low velocity shortening (around 0.9 T0): their dispersion changes very little. This shows that they must be detaching very early in the working stroke. However, at loads around 0.5 T0, the mean lever arm angle is about half way towards the end of the working stroke, and the dispersion of lever arm angles (with a uniform dispersion) is such as to distribute the heads throughout the whole of the working stroke. At higher velocities of shortening (at 0.3 T0), the mean position shifts further towards the end of the stroke, and the dispersion increases further. The details of the measurements, together with other data on muscle indicate that the force-generating mechanism within the myosin heads must have some unexpected properties.

  18. Shortening Tuberculosis Treatment With Fluoroquinolones: Lost in Translation?

    Lanoix, Jean-Philippe; Chaisson, Richard E; Nuermberger, Eric L


    The disappointing recent failure of fluoroquinolone-containing regimens to shorten the duration of tuberculosis treatment in costly phase 3 trials has raised serious questions about the reliability of preclinical tuberculosis models, especially mice, and the current paradigm of regimen development. Therefore we re-examined data from murine models and early-stage clinical trials on which the pivotal trials were based, concluding that phase 3 trial results were in line with preceding studies. Finally, we offer suggestions for a more efficient and integrated preclinical and clinical regimen development program where quantitative pharmacokinetic and pharmacodynamic models more predictive of curative treatment durations are set forth. © The Author 2015. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail



    In Discrete Multi-Tone (DMT) modulation systems, the well-known technique to overcome the Inter-Carrier Interference (ICI)/Inter-Symbol Interference (ISI) caused by the inadequate Cyclic Prefix (CP) length is to use a Time-Domain Equalizer (TDE) at the receiver front-end. An algorithm used to calculate the coefficients of the optimal shortening Time Domain Equalizer (TDE) was given by Melsa. However, this al gorithm requires that the length of the TDE must be smaller than or equal to the memory length of the target impulse response. This paper modifies this algorithm and makes it not only fit for calculating the coefficients of the TDE with arbitrary length, but also have a much less computational time.

  20. [A shortened scale for overall, emotional and social loneliness].

    de Jong Gierveld, J; van Tilburg, T


    Loneliness is an indicator of social well-being and pertains to the feeling of missing an intimate relationship (emotional loneliness) or missing a wider social network (social loneliness). The 11-item De Jong Gierveld scale has proved to be a valid and reliable measuring instrument for overall, emotional and social loneliness, although its length has sometimes rendered it difficult to use the scale in large surveys. In this study, we empirically tested a shortened version of the scale on data from two surveys (N=9448). Confirmatory factor analyses confirmed the specification of two latent factors. Congruent validity and the relationship with determinants (partner status, health) proved to be optimal. The 6-item De Jong Gierveld scale is a reliable and valid measuring instrument for overall, emotional and social loneliness, which is suitable for large surveys.

  1. Systemic Lidocaine Shortens Length of Hospital Stay After Colorectal Surgery

    Herroeder, Susanne; Pecher, Sabine; Schönherr, Marianne E.; Kaulitz, Grit; Hahnenkamp, Klaus; Friess, Helmut; Böttiger, Bernd W.; Bauer, Harry; Dijkgraaf, ↶oMarcel G. W.; Durieux, Marcel E.; Hollmann, Markus W.


    Objective: To characterize the beneficial effects of perioperative systemic lidocaine on length of hospital stay, gastrointestinal motility, and the inflammatory response after colorectal surgery. Summary Background Data: Surgery-induced stimulation of the inflammatory response plays a major role in the development of several postoperative disorders. Local anesthetics possess anti-inflammatory activity and are thought to positively affect patients' outcome after surgery. This double-blinded, randomized, and placebo-controlled trial aimed to evaluate beneficial effects of systemic lidocaine and to provide insights into underlying mechanisms. Methods: Sixty patients undergoing colorectal surgery, not willing or unable to receive an epidural catheter, were randomly assigned to lidocaine or placebo treatment. Before induction of general anesthesia, an intravenous lidocaine bolus (1.5 mg/kg) was administered followed by a continuous lidocaine infusion (2 mg/min) until 4 hours postoperatively. Length of hospital stay, gastrointestinal motility, and pain scores were recorded and plasma levels or expression of pro- and anti-inflammatory mediators determined. Results: Lidocaine significantly accelerated return of bowel function and shortened length of hospital stay by one day. No difference could be observed in daily pain ratings. Elevated plasma levels of IL-6, IL-8, complement C3a, and IL-1ra as well as expression of CD11b, l- and P-selectin, and platelet-leukocyte aggregates were significantly attenuated by systemic lidocaine. Conclusions: Perioperative intravenous lidocaine not only improved gastrointestinal motility but also shortened length of hospital stay significantly. Anti-inflammatory activity modulating the surgery-induced stress response may be one potential mechanism. Systemic lidocaine may thus provide a convenient and inexpensive approach to improve outcome for patients not suitable for epidural anesthesia. PMID:17667496

  2. Cricket antennae shorten when bending (Acheta domesticus L.

    Catherine eLoudon


    Full Text Available Insect antennae are important mechanosensory and chemosensory organs. Insect appendages, such as antennae, are encased in a cuticular exoskeleton and are thought to bend only between segments or subsegments where the cuticle is thinner, more flexible, or bent into a fold. There is a growing appreciation of the dominating influence of folds in the mechanical behavior of a structure, and the bending of cricket antennae was considered in this context. Antennae will bend or deflect in response to forces, and the resulting bending behavior will affect the sensory input of the antennae. In some cricket antennae, such as in those of Acheta domesticus, there are a large number (>100 of subsegments (flagellomeres that vary in their length. We evaluated whether these antennae bend only at the joints between flagellomeres, which has always been assumed but not tested. In addition we questioned whether an antenna undergoes a length change as it bends, which would result from some patterns of joint deformation. Measurements using light microscopy and SEM were conducted on both male and female adult crickets (Acheta domesticus with bending in four different directions: dorsal, ventral, medial and lateral. Bending occurred only at the joints between flagellomeres, and antennae shortened a comparable amount during bending, regardless of sex or bending direction. The cuticular folds separating antennal flagellomeres are not very deep, and therefore as an antenna bends, the convex side (in tension does not have a lot of slack cuticle to unfold and does not lengthen during bending. Simultaneously on the other side of the antenna, on the concave side in compression, there is an increasing overlap in the folded cuticle of the joints during bending. Antennal shortening during bending would prevent stretching of antennal nerves and may promote hemolymph exchange between the antenna and head.

  3. Two dimensional velocity distribution in open channels using Renyi entropy

    Kumbhakar, Manotosh; Ghoshal, Koeli


    In this study, the entropy concept is employed for describing the two-dimensional velocity distribution in an open channel. Using the principle of maximum entropy, the velocity distribution is derived by maximizing the Renyi entropy by assuming dimensionless velocity as a random variable. The derived velocity equation is capable of describing the variation of velocity along both the vertical and transverse directions with maximum velocity occurring on or below the water surface. The developed model of velocity distribution is tested with field and laboratory observations and is also compared with existing entropy-based velocity distributions. The present model has shown good agreement with the observed data and its prediction accuracy is comparable with the other existing models.

  4. New reconstruction algorithm allows shortened acquisition time for myocardial perfusion SPECT

    Valenta, Ines; Treyer, Valerie; Husmann, Lars; Gaemperli, Oliver; Schindler, Michael J.; Herzog, Bernhard A.; Veit-Heibach, Patrick; Pazhenkottil, Aju P.; Kaufmann, Philipp A. [University Hospital Zurich, Cardiac Imaging, Zurich (Switzerland); University of Zurich, Zurich Center for Integrative Human Physiology, Zurich (Switzerland); Buechel, Ronny R.; Nkoulou, Rene [University Hospital Zurich, Cardiac Imaging, Zurich (Switzerland)


    Shortening scan time and/or reducing radiation dose at maintained image quality are the main issues of the current research in radionuclide myocardial perfusion imaging (MPI). We aimed to validate a new iterative reconstruction (IR) algorithm for SPECT MPI allowing shortened acquisition time (HALF time) while maintaining image quality vs. standard full time acquisition (FULL time). In this study, 50 patients, referred for evaluation of known or suspected coronary artery disease by SPECT MPI using 99mTc-Tetrofosmin, underwent 1-day adenosine stress 300 MBq/rest 900 MBq protocol with standard (stress 15 min/rest 15 min FULL time) immediately followed by short emission scan (stress 9 min/rest 7 min HALF time) on a Ventri SPECT camera (GE Healthcare). FULL time scans were processed with IR, short scans were additionally processed with a recently developed software algorithm for HALF time emission scans. All reconstructions were subsequently analyzed using commercially available software (QPS/QGS, Cedars Medical Sinai) with/without X-ray based attenuation correction (AC). Uptake values (percent of maximum) were compared by regression and Bland-Altman (BA) analysis in a 20-segment model. HALF scans yielded a 96% readout and 100% clinical diagnosis concordance compared to FULL. Correlation for uptake in each segment (n = 1,000) was r = 0.87at stress (p < 0.001) and r = 0.89 at rest (p < 0.001) with respective BA limits of agreement of -11% to 10% and -12% to 11%. After AC similar correlation (r = 0.82, rest; r = 0.80, stress, both p < 0.001) and BA limits were found (-12% to 10%; -13% to 12%). With the new IR algorithm, SPECT MPI can be acquired at half of the scan time without compromising image quality, resulting in an excellent agreement with FULL time scans regarding to uptake and clinical conclusion. (orig.)

  5. Cortical T2 signal shortening in amyotrophic lateral sclerosis is not due to iron deposits

    Hecht, M.J.; Neundoerfer, B. [University of Erlangen-Nurenberg, Department of Neurology, Erlangen (Germany); Fellner, C.; Fellner, F.A. [University of Erlangen-Nurenberg, Institute of Diagnostic Radiology, Erlangen (Germany); Landes-Nervenklinik Wagner-Jauregg, Institute of Radiology, Linz (Austria); Schmid, A. [University of Erlangen-Nurenberg, Institute of Diagnostic Radiology, Erlangen (Germany)


    Signal shortening of the motor cortex in T2-weighted MR images is a frequent finding in patients with amyotrophic lateral sclerosis (ALS). The cause of signal shortening in ALS is unknown, although iron deposits have been suggested. To test this hypothesis, we acquired T2*-weighted gradient-echo (GRE) MR images in addition to T2-weighted turbo spin-echo in 69 patients with ALS. Signal shortening in T2-weighted images was found in 31 patients. In T2*-weighted GRE images, only three patients had signal shortening. One patient with additional bifrontal haemorrhage had frontal but no motor cortex signal shortening. Iron deposits do not cause cortical signal shortening in patients with ALS predominantly. Other factors are presumably more important in the generation of cortical T2 shortening in ALS. (orig.)

  6. Tachoastrometry: astrometry with radial velocities

    Pasquini, L; Lombardi, M; Monaco, L; Leão, I C; Delabre, B


    Spectra of composite systems (e.g., spectroscopic binaries) contain spatial information that can be retrieved by measuring the radial velocities (i.e., Doppler shifts) of the components in four observations with the slit rotated by 90 degrees in the sky. By using basic concepts of slit spectroscopy we show that the geometry of composite systems can be reliably retrieved by measuring only radial velocity differences taken with different slit angles. The spatial resolution is determined by the precision with which differential radial velocities can be measured. We use the UVES spectrograph at the VLT to observe the known spectroscopic binary star HD 188088 (HIP 97944), which has a maximum expected separation of 23 milli-arcseconds. We measure an astrometric signal in radial velocity of 276 \\ms, which corresponds to a separation between the two components at the time of the observations of 18 $\\pm2$ milli-arcseconds. The stars were aligned east-west. We describe a simple optical device to simultaneously record p...

  7. Transferability between Isolated Joint Torques and a Maximum Polyarticular Task: A Preliminary Study

    Costes Antony


    Full Text Available The aims of this study were to determine if isolated maximum joint torques and joint torques during a maximum polyarticular task (i.e. cycling at maximum power are correlated despite joint angle and velocity discrepancies, and to assess if an isolated joint-specific torque production capability at slow angular velocity is related to cycling power. Nine cyclists completed two different evaluations of their lower limb maximum joint torques. Maximum Isolated Torques were assessed on isolated joint movements using an isokinetic ergometer and Maximum Pedalling Torques were calculated at the ankle, knee and hip for flexion and extension by inverse dynamics during cycling at maximum power. A correlation analysis was made between Maximum Isolated Torques and respective Maximum Pedalling Torques [3 joints x (flexion + extension], showing no significant relationship. Only one significant relationship was found between cycling maximum power and knee extension Maximum Isolated Torque (r=0.68, p<0.05. Lack of correlations between isolated joint torques measured at slow angular velocity and the same joint torques involved in a polyarticular task shows that transfers between both are not direct due to differences in joint angular velocities and in mono-articular versus poly articular joint torque production capabilities. However, this study confirms that maximum power in cycling is correlated with slow angular velocity mono-articular maximum knee extension torque.


    REN Kun; FU Jianzhong; CHEN Zichen


    To deal with over-shooting and gouging in high speed machining, a novel approach for velocity smooth link is proposed. Considering discrete tool path, cubic spline curve fitting is used to find dangerous points, and according to spatial geometric properties of tool path and the kinematics theory, maximum optimal velocities at dangerous points are obtained. Based on method of velocity control characteristics stored in control system, a fast algorithm for velocity smooth link is analyzed and formulated. On-line implementation results show that the proposed approach makes velocity changing more smoothly compared with traditional velocity control methods and improves productivity greatly.

  9. High-velocity clouds

    Wakker, BP; vanWoerden, H


    High-velocity clouds (HVCs) consist of neutral hydrogen (HI) at velocities incompatible with a simple model of differential galactic rotation; in practice one uses \\v(LSR)\\ greater than or equal to 90 km/s to define HVCs. This review describes the main features of the sky and velocity distributions,

  10. Transverse Spectral Velocity Estimation

    Jensen, Jørgen Arendt


    A transverse oscillation (TO)-based method for calculating the velocity spectrum for fully transverse flow is described. Current methods yield the mean velocity at one position, whereas the new method reveals the transverse velocity spectrum as a function of time at one spatial location. A convex...

  11. A method to deconvolve stellar rotational velocities

    Cure, Michel; Cassetti, Julia; Christen, Alejandra


    Rotational speed is an important physical parameter of stars and knowing the distribution of stellar rotational velocities is essential for the understanding stellar evolution. However, it cannot be measured directly but the convolution of the rotational speed and the sine of the inclination angle, $v \\sin i$. We developed a method to deconvolve this inverse problem and obtain the cumulative distribution function (CDF) for stellar rotational velocities extending the work of Chandrasekhar & M\\"unch (1950). This method is applied a) to theoretical synthetic data recovering the original velocity distribution with very small error; b) to a sample of about 12.000 field main--sequence stars, corroborating that the velocity distribution function is non--Maxwellian, but is better described by distributions based on the concept of maximum entropy, such as Tsallis or Kaniadakis distribution functions. This is a very robust and novel method that deconvolve the rotational velocity cumulative distribution function fro...

  12. Radial velocity moments of dark matter haloes

    Wojtak, R; Gottlöber, S; Mamon, G A; Wojtak, Radoslaw; Lokas, Ewa L.; Gottloeber, Stefan; Mamon, Gary A.


    Using cosmological N-body simulations we study the radial velocity distribution in dark matter haloes focusing on the lowest-order even moments, dispersion and kurtosis. We determine the properties of ten massive haloes in the simulation box approximating their density distribution by the NFW formula characterized by the virial mass and concentration. We also calculate the velocity anisotropy parameter of the haloes and find it mildly radial and increasing with distance from the halo centre. The radial velocity dispersion of the haloes shows a characteristic profile with a maximum, while the radial kurtosis profile decreases with distance starting from a value close to Gaussian near the centre. We therefore confirm that dark matter haloes possess intrinsically non-Gaussian, flat-topped velocity distributions. We find that the radial velocity moments of the simulated haloes are very well reproduced by the solutions of the Jeans equations obtained for the halo parameters with the anisotropy measured in the simu...

  13. Contraction-specific differences in maximal muscle power during stretch-shortening cycle movements in elderly males and females

    Caserotti, Paolo; Aagaard, Per; Simonsen, Erik Bruun


    Aging, muscle power, stretch-shortening cycle, eccentric muscle actions, concentric contractions......Aging, muscle power, stretch-shortening cycle, eccentric muscle actions, concentric contractions...

  14. EMG signal amplitude normalization technique in stretch-shortening cycle movements.

    Allison, G T; Marshall, R N; Singer, K P


    Analysis of functional movements using surface electromyography (EMG) often involves recording both eccentric and concentric muscle activity during a stretch-shorten cycle (SSC). The techniques used for amplitude normalization are varied and are independent of the type of muscle activity involved. The purpose of this study was: (i) to determine the effect of 11 amplitude normalization techniques on the coefficient of variation (CV) during the eccentric and concentric phases of the SSC; and (ii) to establish the effect of the normalization techniques on the EMG signal under variable load and velocity. The EMG signal of the biceps brachii of eight normal subjects was recorded under four SSC conditions and three levels of isometric contraction. The 11 derived normalization values were total rms, mean rms and peak rms (100 ms time constant) for the isometric contractions and the mean rms and peak rms values of the ensemble values for each set of isotonic contractions. Normalization using maximal voluntary isometric contractions (MVIC), irrespective of rms processing (total, mean or peak), demonstrated greater CV above the raw data for both muscle actions. Mean ensemble values and submaximal isometric recordings reduced the CV of concentric data. No amplitude normalization technique reduced the CV for eccentric data under loaded conditions. An ANOVA demonstrated significant (P concentric raw data and an interaction (P < 0.05) for raw eccentric data. No significant effects were demonstrated for changes in velocity when the data were normalized using mean rms values. The reduction of the CV should not be at the expense of true biological variance and current normalization techniques poorly serve the analysis of eccentric muscle activity during the SSC. Copyright © 1993. Published by Elsevier Ltd.




    Full Text Available Despite the great success, seminal Huxley's sliding filament model broadly fails to explain the steady state behavior of stretched activated skeletal muscles. Here, a new self-consistent solution to the fundamental kinetic equation for the distribution of actin-myosin linkages (cross-bridges is proposed in light of the generalized thermodynamic theory of fluctuations, thus substituting the transition state theory traditionally used for the transition rates. The unified description for mechanism of the force output in both shortening and stretching regimes is attributed to the interplay between the uniformly-state distributed, thermodynamically equilibrated myosin heads attached to actin filaments and asymmetrically-state distributed, mechanically equilibrated rotating myosin heads. The crossover between two steady regimes is associated with a reconstruction of the cross-bridge domains and change their attach-detach rates, leaving unchanged basic mechanical characteristics. Theory suggests a unified generic force-velocity equation, using only a single combination of the cross-bridge parameters for each regime, while Huxley's approach (1957 as well as its subsequent modifications, requires four adjustable parameters to fit the same data.

  16. Deciphering oblique shortening of central Alborz in Iran using geodetic data

    Vernant, Ph.; Nilforoushan, F.; Chéry, J.; Bayer, R.; Djamour, Y.; Masson, F.; Nankali, H.; Ritz, J.-F.; Sedighi, M.; Tavakoli, F.


    The Alborz is a narrow (100 km) and elevated (3000 m) mountain belt which accommodates the differential motion between the Sanandaj-Sirjan zone in central Iran and the South Caspian basin. GPS measurements of 12 geodetic sites in Central Alborz between 2000 and 2002 allow to constrain the motion of the belt with respect to western Eurasia. One site velocity on the Caspian shoreline suggests that the South Caspian basin moves northwest at a rate of 6±2 mm/year with respect to western Eurasia. North-South shortening across the Alborz occurs at 5±2 mm/year. To the South, deformation seems to extend beyond the piedmont area, probably due to active thrusting on the Pishva fault. We also observe a left-lateral shear of the overall belt at a rate of 4±2 mm/year, consistent with the geological motion observed along E-W active strike-slip faults inside the belt (e.g., the Mosha fault).

  17. Chemical Sharpening, Shortening, and Unzipping of Boron Nitride Nanotubes

    Liao, Yunlong; Chen, Zhongfang; Connell, John W.; Fay, Catharine C.; Park, Cheol; Kim, Jae-Woo; Lin, Yi


    Boron nitride nanotubes (BNNTs), the one-dimensional member of the boron nitride nanostructure family, are generally accepted to be highly inert to oxidative treatments and can only be covalently modifi ed by highly reactive species. Conversely, it is discovered that the BNNTs can be chemically dispersed and their morphology modifi ed by a relatively mild method: simply sonicating the nanotubes in aqueous ammonia solution. The dispersed nanotubes are significantly corroded, with end-caps removed, tips sharpened, and walls thinned. The sonication treatment in aqueous ammonia solution also removes amorphous BN impurities and shortened BNNTs, resembling various oxidative treatments of carbon nanotubes. Importantly, the majority of BNNTs are at least partially longitudinally cut, or "unzipped". Entangled and freestanding BN nanoribbons (BNNRs), resulting from the unzipping, are found to be approximately 5-20 nm in width and up to a few hundred nanometers in length. This is the fi rst chemical method to obtain BNNRs from BNNT unzipping. This method is not derived from known carbon nanotube unzipping strategies, but is unique to BNNTs because the use of aqueous ammonia solutions specifi cally targets the B-N bond network. This study may pave the way for convenient processing of BNNTs, previously thought to be highly inert, toward controlling their dispersion, purity, lengths, and electronic properties.

  18. Shortening a Patient Experiences Survey for Medical Homes

    Judy H. Ng


    Full Text Available The Consumer Assessment of Healthcare Providers and Systems—Patient-Centered Medical Home (CAHPS PCMH Survey assesses patient experiences reflecting domains of care related to general patient experience (access to care, communication with providers, office staff interaction, provider rating and PCMH-specific aspects of patient care (comprehensiveness of care, self-management support, shared decision making. The current work compares psychometric properties of the current survey and a proposed shortened version of the survey (from 52 to 26 adult survey items, from 66 to 31 child survey items. The revisions were based on initial psychometric analysis and stakeholder input regarding survey length concerns. A total of 268 practices voluntarily submitted adult surveys and 58 submitted child survey data to the National Committee for Quality Assurance in 2013. Mean unadjusted scores, practice-level item and composite reliability, and item-to-scale correlations were calculated. Results show that the shorter adult survey has lower reliability, but still it still meets general definitions of a sound survey for the adult version, and resulted in few changes to mean scores. The impact was more problematic for the pediatric version. Further testing is needed to investigate approaches to improving survey response and the relevance of survey items in informing quality improvement.

  19. The different muscle-energetics during shortening and stretch.

    Jarosch, Robert


    The helical shape of the thin filaments causes their passive counterclockwise rotation during muscle stretch that increases tensile stress and torque at first by unwinding and then by winding up the four anchoring Z-filaments. This means storage of energy in the series elastic Z-filaments and a considerable decrease of the liberated energy of heat and work to (h-w(ap)), where h is the heat energy and w(ap) the stretch energy induced from outside by an apparatus. The steep thin filament helix with an inclination angle of 70° promotes the passive rotation during stretch, but impedes the smooth sliding of shortening by increased friction and production of frictional heat. The frictional heat may be produced by the contact with the myosin cross-bridges: (1) when they passively snap on drilling thin filaments from cleft to cleft over a distance 2 × 2.7 nm = 5.4 nm between the globular actin monomers in one groove, causing stepwise motion; or (2) when they passively cycle from one helical groove to the next (distance 36 nm). The latter causes more heat and may take place on rotating thin filaments without an effective forward drilling ("idle rotation"), e.g., when they produce "unexplained heat" at the beginning of an isometric tetanus. In an Appendix to this paper the different states of muscle are defined. The function of its most important components is described and rotation model and power-stroke model of muscular contraction is compared.

  20. Leg stiffness modulation during exhaustive stretch-shortening cycle exercise.

    Kuitunen, S; Kyröläinen, H; Avela, J; Komi, P V


    The present study examined the effects of muscle activity modulation on leg stiffness during an exhaustive stretch-shortening cycle (SSC) exercise in eight male subjects. Reaction force, electromyography (EMG) of the soleus (Sol), gastrocnemius (Ga) and vastus lateralis (VL) muscles and sledge seat position were recorded during the SSC exercise, consisting of 100 maximal intermittent drop jumps followed by a continuous submaximal jumping until exhaustion, on a sledge apparatus. Metabolic loading was determined by measuring blood lactate (La). No change was found in leg stiffness during the maximal jumps, whereas the subsequent submaximal jumping induced a significant reduction by 27+/-12% (PEMG ratio between the braking and push-off phases in Sol (r=0.81, PEMG ratio at the end of the submaximal jumping in Sol (r=-0.88, Pmodulation between the braking and push-off phases in the triceps surae muscle, particularly in Ga, plays an important role in leg stiffness adjustments during fatiguing SSC exercise. It is suggested that efficient activity modulation (i.e. high EMG ratio) of the triceps surae muscle during an intensive fatiguing SSC exercise may postpone the exhaustion and development of metabolic fatigue.

  1. Frequency-velocity mismatch: a fundamental abnormality in parkinsonian gait.

    Cho, Catherine; Kunin, Mikhail; Kudo, Koji; Osaki, Yasuhiro; Olanow, C Warren; Cohen, Bernard; Raphan, Theodore


    Gait dysfunction and falling are major sources of disability for patients with advanced Parkinson's disease (PD). It is presently thought that the fundamental defect is an inability to generate normal stride length. Our data suggest, however, that the basic problem in PD gait is an impaired ability to match step frequency to walking velocity. In this study, foot movements of PD and normal subjects were monitored with an OPTOTRAK motion-detection system while they walked on a treadmill at different velocities. PD subjects were also paced with auditory stimuli at different frequencies. PD gait was characterized by step frequencies that were faster and stride lengths that were shorter than those of normal controls. At low walking velocities, PD stepping had a reduced or absent terminal toe lift, which truncated swing phases, producing shortened steps. Auditory pacing was not able to normalize step frequency at these lower velocities. Peak forward toe velocities increased with walking velocity and PD subjects could initiate appropriate foot dynamics during initial phases of the swing. They could not control the foot appropriately in terminal phases, however. Increased treadmill velocity, which matched the natural PD step frequency, generated a second toe lift, normalizing step size. Levodopa increased the bandwidth of step frequencies, but was not as effective as increases in walking velocity in normalizing gait. We postulate that the inability to control step frequency and adjust swing phase dynamics to slower walking velocities are major causes for the gait impairment in PD.

  2. Radar velocity tomography in anisotropic media

    Kim, Jung Ho; Cho, Seong Jun; Yi Myeong Jong; Chung, Seung Hwan [Korea Institute of Geology Mining and Materials, Taejon (Korea, Republic of)


    Radar tomography inversion method was developed in the elliptic anisotropic environment with the parametrization of maximum, minimum velocity, and the direction of symmetry axis. Nonlinear least-square method with smoothness constraint was adopted as inversion scheme. Newly developed algorithm was successfully tested with the 2-D numerical cross-borehole data in isotropic environment. Seismic data from physical modelling in partially anisotropic environment was also inverted and compared with the reconstruction technique assuming isotropic media. We could confirm the effectiveness of our algorithm, even though the tested data were generated from isotropic or partially anisotropic media. Cross-hole radar field data in limestone area in Korea was analyzed that the limestone bedrock is systematically anisotropic in the sense of radar application. The data set was inverted with the new anisotropy algorithm. The anisotropic effect in the data was corrected and also inverted for the comparison through the algorithm with isotropic assumption. Applying two different algorithm and comparing the various images, the tomographic image of maximum velocity from anisotropic inversion could give the most excellent way to visualize underground. An addition to the high resolution image, we could grasp some information on the material type from the feature of maximum velocity distribution the degree of anisotropy which can be inferred from the ratio of maximum and minimum velocity. The newly developed algorithm will be expected to provide a good way to image underground, especially in sedimentary or metamorphosed bedrock. (author). 9 refs., 21 figs.

  3. Circular smooth muscle contributes to esophageal shortening during peristalsis

    Anil K Vegesna; Keng-Yu Chuang; Ramashesai Besetty; Steven J Phillips; Alan S Braverman; Mary F Barbe; Michael R Ruggieri


    AIM:To study the angle between the circular smooth muscle (CSM) and longitudinal smooth muscle (LSM) fibers in the distal esophagus.METHODS:In order to identify possible mechanisms for greater shortening in the distal compared to proximal esophagus during peristalsis,the angles between the LSM and CSM layers were measured in 9 cadavers.The outer longitudinal layer of the muscularis propria was exposed after stripping the outer serosa.The inner circular layer of the muscularis propria was then revealed after dissection of the esophageal mucosa and the underlying muscularis mucosa.Photographs of each specimen were taken with half of the open esophagus folded back showing both the outer longitudinal and inner circular muscle layers.Angles were measured every one cm for 10 cm proximal to the squamocolumnar junction (SCJ) by two independent investigators.Two human esophagi were obtained from organ transplant donors and the angles between the circular and longitudinal smooth muscle layers were measured using micro-computed tomography (micro CT) and Image J software.RESULTS:All data are presented as mean ± SE.The CSM to LSM angle at the SCJ and 1 cm proximal to SCJ on the autopsy specimens was 69.3 ± 4.62 degrees vs 74.9 ± 3.09 degrees,P =0.32.The CSM to LSM angle at SCJ were statistically significantly lower than at 2,3,4 and 5 cm proximal to the SCJ,69.3 ± 4.62 degrees vs 82.58 ± 1.34 degrees,84.04 ± 1.64 degrees,84.87 ± 1.04 degrees and 83.72 ± 1.42 degrees,P =0.013,P =0.008,P =0.004,P =0.009 respectively.The CSM to LSM angle at SCJ was also statistically significantly lower than the angles at 6,7 and 8 cm proximal to the SCJ,69.3 ± 4.62 degrees vs 80.18 ± 2.09 degrees,81.81 ± 1.75 degrees and 80.96 ± 2.04 degrees,P =0.05,P =0.02,P =0.03 respectively.The CSM to LSM angle at 1 cm proximal to SCJ was statistically significantly lower than at 3,4 and 5 cm proximal to the SCJ,74.94 ± 3.09 degrees vs 84.04 ± 1.64 degrees,84.87± 1.04 degrees and 83.72 ± 1

  4. Velocity selective optical pumping

    Aminoff, C. G.; Pinard, M.


    We consider optical pumping with a quasi monochromatic tunable light beam, in the low intensity limit where a rate equation regime is obtained The velocity selective optical pumping (V.S.O.P.) introduces a correlation between atomic velocity and internal variables in the ground (or metastable) state. The aim of this article is to evaluate these atomic observables (orientation, alignment, population) as a function of velocity, using a phenomenological description of the relaxation effect of co...

  5. GPS computer navigators to shorten EMS response and transport times.

    Ota, F S; Muramatsu, R S; Yoshida, B H; Yamamoto, L G


    GPS (global positioning satellite system to determine one's position on earth) units have become inexpensive and compact. The purpose of this study is to assess the effectiveness of a GPS enhanced computer street map navigator to improve the ability of EMS drivers in an urban setting to locate their destination and shorten response times. For part I, residential addresses in the city were randomly selected from a telephone directory. Two driver/navigator teams were assigned to drive to the address adhering to speed limits. One team used a standard street map, whereas the other team used a GPS computer navigator. The travel time and distance of the runs were compared. For part II, the computer GPS navigator was placed on an ambulance to supplement their normal methods of navigation to find the address requesting EMS. After the run was completed, EMS providers were interviewed to determine their opinion of whether the GPS navigator was helpful. For part I the results showed that in the 29 initial test runs, comparing the GPS team versus the standard map team, the mean distances traveled were 8.7 versus 9.0 kilometers (not significant) and the mean travel times were 13.5 versus 14.6 minutes (P=.02), respectively. The GPS team arrived faster in 72% runs. For part II the results showed that most EMS providers surveyed noted that the GPS computer navigator enhanced their ability to find the destination and all EMS providers acknowledged that it would enhance their ability to find a destination in an area in which they were unfamiliar. These results suggest that a portable GPS computer navigator system is helpful and can enhance the ability of prehospital care providers to locate their destination. Because these units are accurate and inexpensive, GPS computer navigators may be a valuable tool in reducing pre-hospital transport times.

  6. Changes in the soleus muscle architecture after exhausting stretch-shortening cycle exercise in humans.

    Ishikawa, M; Dousset, E; Avela, J; Kyröläinen, H; Kallio, J; Linnamo, V; Kuitunen, S; Nicol, C; Komi, P V


    This study focused on the architectural changes in the muscle-tendon complex during the immediate and secondary (delayed) reductions of performance (bimodal recovery) caused by an exhaustive rebound type stretch-shortening cycle (SSC) exercise. The isometric plantar flexor torque during maximum voluntary contraction (MVC) was measured together with recording of electromyography (EMG) and ultrasonography from the soleus muscle before (BEF), after (AFT), 2 h (2H), 2 and 8 days (2D, 8D) after the SSC exercise (n=8). The performance variables (MVC torque and EMG activation) followed the bimodal recovery patterns. This was not the case in the changes of the fascicle length and muscle thickness. The relative torque changes in MVC correlated positively (R=0.78, P=0.02) to the corresponding averaged EMG changes between BEF and 2H (BEF-->2H); the significance disappeared in the comparison between 2H and 2D (2H-->2D), during which period MVC showed a secondary reduction. The relative torque changes in MVC showed no correlation with the changes in muscle thickness between BEF-2H. However, this correlation between 2H-2D was negative (R=-0.85, PMVC increased at 2H, and then decreased more at 2D than 2H (PMVC could be related to the increase in muscle volume.

  7. Telomeres shorten more slowly in slow-aging wild animals than in fast-aging ones.

    Dantzer, Ben; Fletcher, Quinn E


    Research on the physiological causes of senescence aim to identify common physiological mechanisms that explain age-related declines in fitness across taxonomic groups. Telomeres are repetitive nucleotide sequences found on the ends of eukaryotic chromosomes. Past research indicates that telomere attrition is strongly correlated with inter-specific rates of aging, though these studies cannot distinguish whether telomere attrition is a cause or consequence of the aging process. We extend previous research on this topic by incorporating recent studies to test the hypothesis that telomeres shorten more slowly with age in slow-aging animals than in fast-aging ones. We assembled all studies that have quantified cross-sectional (i.e. between-individual) telomere rates of change (TROC) over the lifespans of wild animals. This included 22 estimates reflecting absolute TROC (TROCabs, bp/yr, primarily measured using the terminal restriction fragment length method), and 10 estimates reflecting relative TROC (TROCrel, relative telomere length/yr, measured using qPCR), from five classes (Aves, Mammalia, Bivalvia, Reptilia, and Actinopterygii). In 14 bird species, we correlated between-individual (i.e. cross-sectional) TROCabs estimates with both maximum lifespan and a phylogenetically-corrected principle component axis (pcPC1) that reflected the slow-fast axis of life-history variation. Bird species characterized by faster life-histories and shorter maximum lifespans had faster TROCabs. In nine studies, both between-individual and within-individual TROC estimates were available (n=8 for TROCabs, n=1 for TROCrel). Within-individual TROC estimates were generally greater than between-individual TROC estimates, which is indicative of selective disappearance of individuals with shorter telomeres. However, the difference between within- and between-individual TROC estimates was only significant in two out of nine studies. The relationship between within-individual TROCabs and maximum

  8. Stretch-shortening cycle muscle power in women and men aged 18-81 years: Influence of age and gender.

    Edwén, C E; Thorlund, J B; Magnusson, S P; Slinde, F; Svantesson, U; Hulthén, L; Aagaard, P


    This study explored the age-related deterioration in stretch-shortening cycle (SSC) muscle power and concurrent force-velocity properties in women and men across the adult life span. A total of 315 participants (women: n = 188; men: n = 127) aged 18-81 years performed maximal countermovement jumps on an instrumented force plate. Maximal SSC leg extension power expressed per kg body mass (Ppeak) was greater in men than in women across the adult age span (P < 0.001); however, this gender difference was progressively reduced with increasing age, because men showed an ∼50% faster rate of decline in SSC power than women (P < 0.001). Velocity at peak power (VPpeak) was greater in men than in women (P < 0.001) but declined at a greater rate in men than in women (P = 0.002). Vertical ground reaction force at peak power (FPpeak) was higher in men than in women in younger adults only (P < 0.001) and the age-related decline was steeper in men than in women (P < 0.001). Men demonstrated a steeper rate of decline in Ppeak than women with progressive aging. This novel finding emerged as a result of greater age-related losses in men for both force and velocity. Consequently, maximal SSC power production was observed to converge between genders when approaching old age.

  9. Crustal structure of the Bighorn Mountains region: Precambrian influence on Laramide shortening and uplift in north-central Wyoming

    Worthington, Lindsay L.; Miller, Kate C.; Erslev, Eric A.; Anderson, Megan L.; Chamberlain, Kevin R.; Sheehan, Anne F.; Yeck, William L.; Harder, Steven H.; Siddoway, Christine S.


    The crustal structure of north-central Wyoming records a history of complex lithospheric evolution from Precambrian accretion to Cretaceous-Paleogene Laramide shortening. We present two active source P wave velocity model profiles collected as part of the Bighorn Arch Seismic Experiment in 2010. Analyses of these velocity models and single-fold reflection data, together with potential field modeling of regional gravity and magnetic signals, constrain crustal structure and thickness of the Bighorn region. We image a west dipping reflection boundary and model a sharp magnetic contact east of the Bighorn Arch that together may delineate a previously undetected Precambrian suture zone. Localized patches of a high-velocity, high-density lower crustal layer (the "7.× layer") occur across the study area but are largely absent beneath the Bighorn Arch culmination. Moho topography is relatively smooth with no large-scale offsets, with depths ranging from ~50 to 37 km, and is largely decoupled from Laramide basement topography. These observations suggest that (1) the edge of the Archean Wyoming craton lies just east of the Bighorn Mountains, approximately 300 km west of previous interpretations, and (2) Laramide deformation localized in an area with thin or absent 7.× layer, due to its relatively weak lower crust, leading to detachment faulting. Our findings show that Precambrian tectonics in northern Wyoming may be more complicated than previously determined and subsequent Laramide deformation may have been critically dependent on laterally heterogeneous crustal structure that can be linked to Precambrian origins.

  10. Estimation of vector velocity


    Using a pulsed ultrasound field, the two-dimensional velocity vector can be determined with the invention. The method uses a transversally modulated ultrasound field for probing the moving medium under investigation. A modified autocorrelation approach is used in the velocity estimation. The new...

  11. Estimation of vector velocity


    Using a pulsed ultrasound field, the two-dimensional velocity vector can be determined with the invention. The method uses a transversally modulated ultrasound field for probing the moving medium under investigation. A modified autocorrelation approach is used in the velocity estimation. The new...

  12. Peyronie's Reconstruction for Maximum Length and Girth Gain: Geometrical Principles

    Paulo H. Egydio


    Full Text Available Peyronie's disease has been associated with penile shortening and some degree of erectile dysfunction. Surgical reconstruction should be based on giving a functional penis, that is, rectifying the penis with rigidity enough to make the sexual intercourse. The procedure should be discussed preoperatively in terms of length and girth reconstruction in order to improve patient satisfaction. The tunical reconstruction for maximum penile length and girth restoration should be based on the maximum length of the dissected neurovascular bundle possible and the application of geometrical principles to define the precise site and size of tunical incision and grafting procedure. As penile rectification and rigidity are required to achieve complete functional restoration of the penis and 20 to 54% of patients experience associated erectile dysfunction, penile straightening alone may not be enough to provide complete functional restoration. Therefore, phosphodiesterase inhibitors, self-injection, or penile prosthesis may need to be added in some cases.

  13. The endothermic ATP hydrolysis and crossbridge attachment steps drive the increase of force with temperature in isometric and shortening muscle.

    Offer, Gerald; Ranatunga, K W


    The isometric tetanic tension of skeletal muscle increases with temperature because attached crossbridge states bearing a relatively low force convert to those bearing a higher force. It was previously proposed that the tension-generating step(s) in the crossbridge cycle was highly endothermic and was therefore itself directly targeted by changes in temperature. However, this did not explain why a rapid rise in temperature (a temperature jump) caused a much slower rate of rise of tension than a rapid length step. This led to suggestions that the step targeted by a temperature rise is not the tension-generating step but is an extra step in the attached pathway of the crossbridge cycle, perhaps located on a parallel pathway. This enigma has been a major obstacle to a full understanding of the operation of the crossbridge cycle. We have now used a previously developed mechano-kinetic model of the crossbridge cycle in frog muscle to simulate the temperature dependence of isometric tension and shortening velocity. We allowed all five steps in the cycle to be temperature-sensitive. Models with different starting combinations of enthalpy changes and activation enthalpies for the five steps were refined by downhill simplex runs and scored by their ability to fit experimental data on the temperature dependence of isometric tension and the relationship between force and shortening velocity in frog muscle. We conclude that the first tension-generating step may be weakly endothermic and that the rise of tension with temperature is largely driven by the preceding two strongly endothermic steps of ATP hydrolysis and attachment of M.ADP.Pi to actin. The refined model gave a reasonable fit to the available experimental data and after a temperature jump the overall rate of tension rise was much slower than after a length step as observed experimentally. The findings aid our understanding of the crossbridge cycle by showing that it may not be necessary to include an additional

  14. Limb shortening in the course of solitary bone cyst treatment - a comparative study

    Glowacki, Maciej [Karol Marcinkowski University of Medical Sciences, Department of Paediatric Orthopaedics, Poznan (Poland); Ignys-O' Byrne, Anna [J. Strus City Hospital, Department of Radiology, Poznan (Poland); Ignys, Iwona [Karol Marcinkowski University of Medical Sciences, Department of Paediatric Gastroenterology and Metabolic Diseases, Poznan (Poland); Wroblewska, Katarzyna [Karol Marcinkowski University of Medical Sciences, Department of Radiology, Poznan (Poland)


    The aim of this paper is to evaluate the frequency of limb shortening in the course of solitary bone cyst treatment. The correlation between the mode of treatment as well as the occurrence of pathological fracture, cyst location, volume, and locularity were examined. A retrospective analysis was carried out on 135 patients where 80 underwent curettage and bone grafting and 55 were administered methylprednisolone injection with a mean time to follow-up of 12 years. Based on clinical and radiological evaluation, limb shortening was found in ten patients when the data before and after treatment was compared. Limb shortening ranging from 1 to 5 cm during the course of the treatment was observed: six in humerus, two in femur, two in tibia. Those with epiphyseal changes, magnetic resonance imaging to evaluate the degree of growth plate damage was performed. Patients with and without limb shortening did not differ statistically regarding the applied method of treatment. The cyst volume was significantly larger in the group of patients with limb shortening when compared to the group of patients with no limb shortening. In patients treated with curettage and bone grafting, the mode of treatment does not increase the frequency of occurrence of iatrogenic limb shortening. In patients with limb shortening, a statistically significant larger volume of the cyst was observed. (orig.)

  15. Shortened preoperative fasting for prevention of complications associated with laparoscopic cholecystectomy: a meta-analysis.

    Xu, Duo; Zhu, Xuejiao; Xu, Yuan; Zhang, Liqing


    Objective Routine fasting (12 h) is always applied before laparoscopic cholecystectomy, but prolonged preoperative fasting causes thirst, hunger, and irritability as well as dehydration, low blood glucose, insulin resistance and other adverse reactions. We assessed the safety and efficacy of a shortened preoperative fasting period in patients undergoing laparoscopic cholecystectomy. Methods We searched PubMed, Embase and Cochrane Central Register of Controlled Trials up to 20 November 2015 and selected controlled trials with a shortened fasting time before laparoscopic cholecystectomy. We assessed the results by performing a meta-analysis using a variety of outcome measures and investigated the heterogeneity by subgroup analysis. Results Eleven trials were included. Forest plots showed that a shortened fasting time reduced the operative risk and patient discomfort. A shortened fasting time also reduced postoperative nausea and vomiting as well as operative vomiting. With respect to glucose metabolism, a shortened fasting time significantly reduced abnormalities in the ratio of insulin sensitivity. The C-reactive protein concentration was also reduced by a shortened fasting time. Conclusions A shortened preoperative fasting time increases patients' postoperative comfort, improves insulin resistance, and reduces stress responses. This evidence supports the clinical application of a shortened fasting time before laparoscopic cholecystectomy.

  16. Effects of stretch and shortening on gene expression in intact myocardium.

    Haggart, Charles R; Ames, Elizabeth G; Lee, Jae K; Holmes, Jeffrey W


    Multiple cues have been suggested as the mechanical stimulus for the heart's hypertrophic response. Our work has previously suggested that the amount of cyclic shortening in cardiomyocytes controls myocyte shape and the amount of stretch controls myocyte size. To identify gene expression changes that occur in response to these mechanical perturbations, we used microarray analysis of papillary muscles cultured for 12 h at physiological or reduced levels of cyclic shortening and physiological or reduced mean stretch. Overall, genes related to extracellular matrix (ECM) were surprisingly prominent in our analysis. Connective tissue growth factor was among a small group of genes regulated by the amount of cyclic shortening regardless of the level of mean stretch, and many more ECM genes were regulated by shortening with reduced amounts of stretch. When we compared our results to gene expression data from an in vivo model of pressure overload (PO), which also decreases myocyte shortening, we found the genes that were commonly regulated in PO and our decreased shortening groups were most significantly enriched for ontology terms related to the ECM, followed by genes associated with mechanosensing and the cytoskeleton. The list of genes regulated in PO and our decreased shortening groups also includes genes known to change early in hypertrophy, such as myosin heavy chain 7, brain natriuretic peptide, and myosin binding protein C. We conclude that in intact myocardium, the amount of cyclic shortening may be an important regulator not only of myocyte genes classically associated with hypertrophy but also of ECM genes.

  17. Compatibility of selected plant-based shortening as lard substitute: microstructure, polymorphic forms and textural properties

    N. A.M. Yanty


    Full Text Available A study was carried out to determine the compatibility of three plant-based shortening mixtures to lard shortening (LD in terms of microstructure, polymorphic forms, and textural properties. The shortenings of binary, ternary, and quaternary fat mixtures were prepared according to a standard procedure by blending mee fat (MF with palm stearin (PS in a 99:1 (w/w ratio; avocado fat (Avo with PS and cocoa butter (CB in a 84:7:9 (w/w ratio; palm oil (PO with PS, soybean oil (SBO and CB in a 38:5:52:5 (w/w ratio, respectively. The triacylglycerol composition, polymorphic forms, crystal morphology, and textural properties of the shortening were evaluated. This study found that all three plant-based shortenings and LD shortening were similar with respect to their consistency, hardness and compression and adhesiveness values. However, all plant-based shortening was found to be dissimilar to LD shortening with respect to microstructure.

  18. Assisting High School Students with Career Indecision Using a Shortened Form of the Career Construction Interview

    Rehfuss, Mark C.; Sickinger, Pamela H.


    A shortened form of the Career Construction Interview (CCI) was used to help high school students struggling with the career decision making process. The shortened instrument is described, as well as, its use with eleventh grade high school students who had low levels of career concern and career curiosity. Students who completed the exercise…

  19. Examining a scaled dynamical system of telomere shortening

    Cyrenne, Benoit M.; Gooding, Robert J.


    A model of telomere dynamics is proposed and examined. Our model, which extends a previously introduced model that incorporates stem cells as progenitors of new cells, imposes the Hayflick limit, the maximum number of cell divisions that are possible. This new model leads to cell populations for which the average telomere length is not necessarily a monotonically decreasing function of time, in contrast to previously published models. We provide a phase diagram indicating where such results would be expected via the introduction of scaled populations, rate constants and time. The application of this model to available leukocyte baboon data is discussed.

  20. Accommodation of collisional shortening along the Alpine plate boundary : plate kinematics vs rheological controls

    Rosenberg, Claudio; Bellahsen, Nicolas


    The style of collision in the Alps varies along strike, reflecting different amounts and different modes of accommodation of collisional shortening. These differences control the patterns of exhumation during collision. Whereas the western Alps largely consist of a metamorphic complex formed during subduction and largely exhumed before the initiation of collision, the subduction nappe-stack of the Central and the Eastern Alps is strongly overprinted by collisional shortening and by Barrovian metamorphism. Based on compiled and new data we estimate amounts of collisional shortening along the strike of the chain and set it in relationship to the geometry of the collisional prism. The western Alpine collisional structures form a very large (in map view), but moderately shortened wedge, terminating in front of a poorly developed Molasse basin. Shortening of this wedge was mainly localized along its external parts, resulting in accretion of basement and cover units thrusted towards the foreland. Back-folding and back-thrusting are barely developed and no shortening takes place in the upper, Adriatic plate. In the Central Alps, the amount of collisional shortening is larger and it is distributed both in the lower and in the upper plate. The collisional prism is bivergent and partitioning of the amount of shortening between the upper and lower plates varies along strike, being most probably controlled by rheological, heterogeneities. The thickened accreted lower plate is strongly affected by Barrovian metamorphism where shortening is largest and localized within a confined area. A deep Molasse basin developed in front of the prism. In the Eastern Alps collisional kinematics vary from east to west, with orogen-parallel displacements dominating in the east and orogen-perpendicular ones in the West, where they culminate in the structural and metamorphic dome of the Tauern Window. Nowhere else in the Alps collisional shortening is so strongly localized in one and the same

  1. Evaluation of canola oil oleogels with candelilla wax as an alternative to shortening in baked goods.

    Jang, Areum; Bae, Woosung; Hwang, Hong-Sik; Lee, Hyeon Gyu; Lee, Suyong


    The oleogels of canola oil with candelilla wax were prepared and utilized as a shortening replacer to produce cookies with a high level of unsaturated fatty acids. The incorporation of candelilla wax (3% and 6% by weight) to canola oil produced the oleogels with solid-like properties. The firmness of the oleogels was lower than that of the shortening at room temperature. A more rapid change in the viscosity with temperature was observed with increasing levels of candelilla wax in the steady shear measurements. The replacement of shortening with oleogels in the cookie formulation reduced both viscoelastic parameters (G' and G") of the cookie doughs. The level of unsaturated fatty acids in the oleogel cookies was distinctly increased up to around 92%, compared to the shortening cookies (47.2%). The cookies with the oleogels showed desirable spreadable property and the replacement of shortening with the oleogels produced cookies with soft eating characteristics.

  2. Predicting species' maximum dispersal distances from simple plant traits.

    Tamme, Riin; Götzenberger, Lars; Zobel, Martin; Bullock, James M; Hooftman, Danny A P; Kaasik, Ants; Pärtel, Meelis


    Many studies have shown plant species' dispersal distances to be strongly related to life-history traits, but how well different traits can predict dispersal distances is not yet known. We used cross-validation techniques and a global data set (576 plant species) to measure the predictive power of simple plant traits to estimate species' maximum dispersal distances. Including dispersal syndrome (wind, animal, ant, ballistic, and no special syndrome), growth form (tree, shrub, herb), seed mass, seed release height, and terminal velocity in different combinations as explanatory variables we constructed models to explain variation in measured maximum dispersal distances and evaluated their power to predict maximum dispersal distances. Predictions are more accurate, but also limited to a particular set of species, if data on more specific traits, such as terminal velocity, are available. The best model (R2 = 0.60) included dispersal syndrome, growth form, and terminal velocity as fixed effects. Reasonable predictions of maximum dispersal distance (R2 = 0.53) are also possible when using only the simplest and most commonly measured traits; dispersal syndrome and growth form together with species taxonomy data. We provide a function (dispeRsal) to be run in the software package R. This enables researchers to estimate maximum dispersal distances with confidence intervals for plant species using measured traits as predictors. Easily obtainable trait data, such as dispersal syndrome (inferred from seed morphology) and growth form, enable predictions to be made for a large number of species.


    Alexander V. Zubovich


    Full Text Available A new method is proposed to define piecewise continuous fields of velocity gradients of recent horizontal movements of the Earth’s crust from spatially discrete data on horizontal velocities of such movements. The method is designed to identify spatial inhomogeneities in the field of horizontal strain rates (e.g., zones of localized deformation and boundaries between areas with different strain rates in considerable detail. It is applied to determine the field of horizontal velocity gradient in the region of the Central Asian GPS network which covers vast territories of the Kyrgyz Tien-Shan and Pamirs mountain ranges, the T arim depression, and the Kazakh Shield (Fig. 1. Calculations are based on GPS survey data obtained at 308 sites from 1995 to 2006 (Fig. 4. The resolution of the proposed method is increased by using a triangulation grid which is much denser than a conventional one (Fig. 2 and 3. As a result, point x on the surface under study is covered by several triangles rather than one (Fig. 5. Strain characteristics at point x are calculated by weighted summation of corresponding characteristics in the cover triangles. Thus, for each point we estimate spin tensor W, which defines angular velocity ω, and components of horizontal strain rate tensor E. These components provide for direct calculation of orientation of principal axes and invariants of E, i.e. maximum stretching E1, maximum shortening E2, velocity divergence E=E1+E2, and maximum shear rates Γ=⎪E1−E2⎪/2 (Fig. 6 to 11. The calculated values are presented in maps which demonstrate that spatial distribution of such values is highly inhomogeneous. Regions with increased values of kinematic characteristics mentioned above stand out sharply against the background. At the same time, spatial distribution of the kinematical characteristics in the Tien Shan region is quite regular: zones of increased absolute values of E2 are mainly oriented in the ENE direction, while the NNW


    Liliana Ioana Vâţă


    Full Text Available The main purpose of the study was to highlight the causes that may lead to reduction of arches: early loss of deciduous teeth, with consecutive dental drifting on the arch, followed by narrowing of the space necessary for the eruption of successional teeth, caries of the deciduous teeth or ectopic eruption of the first permanent molars. The mesial position of M1 had a frequency of 19.31% of the total number of analysed cases; maximum frequencies have been registered for the localization on the lower arch; M1 ectopia has rarely occurred on the studied batch; the frequency of lateral group mesial position was of 10.34% on the studied batch, registering maximum values for the localisation on the upper arch. The early loss of deciduous teeth was identified in almost 30% of the analysed cases, while the reduction of the space necessary for the eruption of successional teeth was registered in almost 39% of cases, space narrowing resulting both from the caries of deciduous teeth and from their early loss.

  5. Experimental study on prediction model for maximum rebound ratio

    LEI Wei-dong; TENG Jun; A.HEFNY; ZHAO Jian; GUAN Jiong


    The proposed prediction model for estimating the maximum rebound ratio was applied to a field explosion test, Mandai test in Singapore.The estimated possible maximum Deak particle velocities(PPVs)were compared with the field records.Three of the four available field-recorded PPVs lie exactly below the estimated possible maximum values as expected.while the fourth available field-recorded PPV lies close to and a bit higher than the estimated maximum possible PPV The comparison results show that the predicted PPVs from the proposed prediction model for the maximum rebound ratio match the field.recorded PPVs better than those from two empirical formulae.The very good agreement between the estimated and field-recorded values validates the proposed prediction model for estimating PPV in a rock mass with a set of ipints due to application of a two dimensional compressional wave at the boundary of a tunnel or a borehole.

  6. Horizontal subduction zones, convergence velocity and the building of the Andes

    Martinod, Joseph; Roperch, Pierrick; Guillaume, Benjamin; Espurt, Nicolas; 10.1016/j.epsl.2010.09.010


    We discuss the relationships between Andean shortening, plate velocities at the trench, and slab geometry beneath South America. Although some correlation exists between the convergence velocity and the westward motion of South America on the one hand, and the shortening of the continental plate on the other hand, plate kinematics neither gives a satisfactory explanation to the Andean segmentation in general, nor explains the development of the Bolivian orocline in Paleogene times. We discuss the Cenozoic history of horizontal slab segments below South America, arguing that they result from the subduction of oceanic plateaus whose effect is to switch the buoyancy of the young subducting plate to positive. We argue that the existence of horizontal slab segments, below the Central Andes during Eocene-Oligocene times, and below Peru and North-Central Chile since Pliocene, resulted (1) in the shortening of the continental plate interiors at a large distance from the trench, (2) in stronger interplate coupling and...

  7. Video Measurement of the Muzzle Velocity of a Potato Gun

    Jasperson, Christopher; Pollman, Anthony


    Using first principles, a theoretical equation for the maximum and actual muzzle velocities for a pneumatic cannon was recently derived. For a fixed barrel length, this equation suggests that the muzzle velocity can be enhanced by maximizing the product of the initial pressure and the volume of the propellant gas and decreasing the projectile…

  8. Video Measurement of the Muzzle Velocity of a Potato Gun

    Jasperson, Christopher; Pollman, Anthony


    Using first principles, a theoretical equation for the maximum and actual muzzle velocities for a pneumatic cannon was recently derived. For a fixed barrel length, this equation suggests that the muzzle velocity can be enhanced by maximizing the product of the initial pressure and the volume of the propellant gas and decreasing the projectile…

  9. OECD Maximum Residue Limit Calculator

    With the goal of harmonizing the calculation of maximum residue limits (MRLs) across the Organisation for Economic Cooperation and Development, the OECD has developed an MRL Calculator. View the calculator.

  10. Radiation Pressure Acceleration: the factors limiting maximum attainable ion energy

    Bulanov, S S; Schroeder, C B; Bulanov, S V; Esirkepov, T Zh; Kando, M; Pegoraro, F; Leemans, W P


    Radiation pressure acceleration (RPA) is a highly efficient mechanism of laser-driven ion acceleration, with with near complete transfer of the laser energy to the ions in the relativistic regime. However, there is a fundamental limit on the maximum attainable ion energy, which is determined by the group velocity of the laser. The tightly focused laser pulses have group velocities smaller than the vacuum light speed, and, since they offer the high intensity needed for the RPA regime, it is plausible that group velocity effects would manifest themselves in the experiments involving tightly focused pulses and thin foils. However, in this case, finite spot size effects are important, and another limiting factor, the transverse expansion of the target, may dominate over the group velocity effect. As the laser pulse diffracts after passing the focus, the target expands accordingly due to the transverse intensity profile of the laser. Due to this expansion, the areal density of the target decreases, making it trans...

  11. Superluminal Recession Velocities

    Davis, T M; Davis, Tamara M.; Lineweaver, Charles H.


    Hubble's Law, v=HD (recession velocity is proportional to distance), is a theoretical result derived from the Friedmann-Robertson-Walker metric. v=HD applies at least as far as the particle horizon and in principle for all distances. Thus, galaxies with distances greater than D=c/H are receding from us with velocities greater than the speed of light and superluminal recession is a fundamental part of the general relativistic description of the expanding universe. This apparent contradiction of special relativity (SR) is often mistakenly remedied by converting redshift to velocity using SR. Here we show that galaxies with recession velocities faster than the speed of light are observable and that in all viable cosmological models, galaxies above a redshift of three are receding superluminally.

  12. Extreme Velocity Wind Sensor

    Perotti, Jose; Voska, Ned (Technical Monitor)


    This presentation provides an overview of the development of new hurricane wind sensor (Extreme Velocity Wind Sensor) for the Kennedy Space Center (KSC) which is designed to withstand winds of up to three hundred miles an hour. The proposed Extreme Velocity Wind Sensor contains no moveable components that would be exposed to extreme wind conditions. Topics covered include: need for new hurricane wind sensor, conceptual design, software applications, computational fluid dynamic simulations of design concept, preliminary performance tests, and project status.

  13. Multiple causes of fatigue during shortening contractions in rat slow twitch skeletal muscle.

    Hortemo, Kristin Halvorsen; Munkvik, Morten; Lunde, Per Kristian; Sejersted, Ole M


    Fatigue in muscles that shorten might have other causes than fatigue during isometric contractions, since both cross-bridge cycling and energy demand are different in the two exercise modes. While isometric contractions are extensively studied, the causes of fatigue in shortening contractions are poorly mapped. Here, we investigate fatigue mechanisms during shortening contractions in slow twitch skeletal muscle in near physiological conditions. Fatigue was induced in rat soleus muscles with maintained blood supply by in situ shortening contractions at 37°C. Muscles were stimulated repeatedly (1 s on/off at 30 Hz) for 15 min against a constant load, allowing the muscle to shorten and perform work. Fatigue and subsequent recovery was examined at 20 s, 100 s and 15 min exercise. The effects of prior exercise were investigated in a second exercise bout. Fatigue developed in three distinct phases. During the first 20 s the regulatory protein Myosin Light Chain-2 (slow isoform, MLC-2s) was rapidly dephosphorylated in parallel with reduced rate of force development and reduced shortening. In the second phase there was degradation of high-energy phosphates and accumulation of lactate, and these changes were related to slowing of muscle relengthening and relaxation, culminating at 100 s exercise. Slowing of relaxation was also associated with increased leak of calcium from the SR. During the third phase of exercise there was restoration of high-energy phosphates and elimination of lactate, and the slowing of relaxation disappeared, whereas dephosphorylation of MLC-2s and reduced shortening prevailed. Prior exercise improved relaxation parameters in a subsequent exercise bout, and we propose that this effect is a result of less accumulation of lactate due to more rapid onset of oxidative metabolism. The correlation between dephosphorylation of MLC-2s and reduced shortening was confirmed in various experimental settings, and we suggest MLC-2s as an important regulator of

  14. Multiple causes of fatigue during shortening contractions in rat slow twitch skeletal muscle.

    Kristin Halvorsen Hortemo

    Full Text Available Fatigue in muscles that shorten might have other causes than fatigue during isometric contractions, since both cross-bridge cycling and energy demand are different in the two exercise modes. While isometric contractions are extensively studied, the causes of fatigue in shortening contractions are poorly mapped. Here, we investigate fatigue mechanisms during shortening contractions in slow twitch skeletal muscle in near physiological conditions. Fatigue was induced in rat soleus muscles with maintained blood supply by in situ shortening contractions at 37°C. Muscles were stimulated repeatedly (1 s on/off at 30 Hz for 15 min against a constant load, allowing the muscle to shorten and perform work. Fatigue and subsequent recovery was examined at 20 s, 100 s and 15 min exercise. The effects of prior exercise were investigated in a second exercise bout. Fatigue developed in three distinct phases. During the first 20 s the regulatory protein Myosin Light Chain-2 (slow isoform, MLC-2s was rapidly dephosphorylated in parallel with reduced rate of force development and reduced shortening. In the second phase there was degradation of high-energy phosphates and accumulation of lactate, and these changes were related to slowing of muscle relengthening and relaxation, culminating at 100 s exercise. Slowing of relaxation was also associated with increased leak of calcium from the SR. During the third phase of exercise there was restoration of high-energy phosphates and elimination of lactate, and the slowing of relaxation disappeared, whereas dephosphorylation of MLC-2s and reduced shortening prevailed. Prior exercise improved relaxation parameters in a subsequent exercise bout, and we propose that this effect is a result of less accumulation of lactate due to more rapid onset of oxidative metabolism. The correlation between dephosphorylation of MLC-2s and reduced shortening was confirmed in various experimental settings, and we suggest MLC-2s as an

  15. Ulnar shortening after TFCC suture repair of Palmer type 1B lesions.

    Wolf, Maya B; Kroeber, Markus W; Reiter, Andreas; Thomas, Susanne B; Hahn, Peter; Horch, Raymund E; Unglaub, Frank


    The objective of this study was to determine functional and subjective outcomes of an ulnar shortening procedure elected by patients who experienced persistent ulno-carpal symptoms following arthroscopic suture repair of a Palmer type 1B lesion. All patients had a dynamic ulna positive variance. Five patients (3 males and 2 females) with arthroscopic repair of Palmer type 1B tears who subsequently underwent ulnar shortening were reviewed. At the time of the arthroscopic repair the patients' average age was 37 +/- 13 years (range 16-52 years). Average time to follow-up was 14 +/- 6 months (range 10-23 months). The average age was 38 +/- 14 years (range 17-53 years) when the ulnar shortening was performed. The second follow-up took place 7 +/- 2 months (range 5-9 months) after ulnar shortening. During the follow-ups, range of motion, grip strength, pain, Modified Mayo Wrist Score, DASH Score, and ulnar length were evaluated. Citing persistent ulno-carpal symptoms, the patients elected ulnar shortening an average of 17 +/- 7months (range 13-29 months) following the arthroscopic repair. Prior to ulnar shortening the average static ulnar variance was 0.2 +/- 1.3 mm (range -1 to 2 mm), the average dynamic ulnar variance was 1.4 +/- 0.5 mm (range 1 to 2 mm). Ulnar shortening brought about further reduction in pain after the arthroscopic repair of the triangular fibrocartilage complex (TFCC) had already reduced it. As measured by a visual analogue scale, the average value after ulnar shortening was 2.2 +/- 2.1 (range 0.7-5.0). The average static ulnar variance was -3.4 +/- 2 mm (range -5 to -1 mm). Patients were very satisfied with the results of the ulnar shortening and four out of five indicated that it had significantly improved their symptoms and they would elect ulnar shortening again. Postoperative range of motion as a percentage of the contralateral side averaged 90% for the extension/flexion arc, 80% for the radial/ulnar deviation arc, and 100% for the pronation

  16. Maximum margin Bayesian network classifiers.

    Pernkopf, Franz; Wohlmayr, Michael; Tschiatschek, Sebastian


    We present a maximum margin parameter learning algorithm for Bayesian network classifiers using a conjugate gradient (CG) method for optimization. In contrast to previous approaches, we maintain the normalization constraints on the parameters of the Bayesian network during optimization, i.e., the probabilistic interpretation of the model is not lost. This enables us to handle missing features in discriminatively optimized Bayesian networks. In experiments, we compare the classification performance of maximum margin parameter learning to conditional likelihood and maximum likelihood learning approaches. Discriminative parameter learning significantly outperforms generative maximum likelihood estimation for naive Bayes and tree augmented naive Bayes structures on all considered data sets. Furthermore, maximizing the margin dominates the conditional likelihood approach in terms of classification performance in most cases. We provide results for a recently proposed maximum margin optimization approach based on convex relaxation. While the classification results are highly similar, our CG-based optimization is computationally up to orders of magnitude faster. Margin-optimized Bayesian network classifiers achieve classification performance comparable to support vector machines (SVMs) using fewer parameters. Moreover, we show that unanticipated missing feature values during classification can be easily processed by discriminatively optimized Bayesian network classifiers, a case where discriminative classifiers usually require mechanisms to complete unknown feature values in the data first.

  17. Maximum Entropy in Drug Discovery

    Chih-Yuan Tseng


    Full Text Available Drug discovery applies multidisciplinary approaches either experimentally, computationally or both ways to identify lead compounds to treat various diseases. While conventional approaches have yielded many US Food and Drug Administration (FDA-approved drugs, researchers continue investigating and designing better approaches to increase the success rate in the discovery process. In this article, we provide an overview of the current strategies and point out where and how the method of maximum entropy has been introduced in this area. The maximum entropy principle has its root in thermodynamics, yet since Jaynes’ pioneering work in the 1950s, the maximum entropy principle has not only been used as a physics law, but also as a reasoning tool that allows us to process information in hand with the least bias. Its applicability in various disciplines has been abundantly demonstrated. We give several examples of applications of maximum entropy in different stages of drug discovery. Finally, we discuss a promising new direction in drug discovery that is likely to hinge on the ways of utilizing maximum entropy.

  18. Characteristics of myocardial postsystolic shortening in patients with coronary artery disease assessed by strain rate imaging

    YANG Li; QIU Qiong; ZHANG Hui-zhong; XIA Jin-xi


    Background Postsystolic shortening (PSS) has been proposed as a marker of myocardial dysfunction. Strain rate imaging (SRI)is a novel ultrasonic technique, allowing reliable and noninvasive measurement of myocardial deformation.The purpose of this study was to investigate the characteristics of myocardial longitudinal PSS by SRI in ischemic and infarct myocardium in patients with coronary artery disease, and to explore its clinical applicability.Methods Eleven patients with angina pectoris, 21 patients with myocardial infarction and 20 healthy subjects were included in the study. Apical four-, three- and two-chamber views were displayed; and septal, lateral, anteroseptal,posterior, anterior and inferior walls of the left ventricle were scanned, respectively. PSS strain (εpss), the ratio of εpss and systolic strain (εpss/εsys), the ratio of εpss and maximum strain (εpss/εmax) and the duration of PSS (Tpss) in ischemic, infarct and normal myocardium were analyzed.Results PSS was found more frequent in the ischemic and infarct segments compared with the normal segments (39%vs 22% and 56% vs 22%, respectively; both P<0.01). It was even more frequent in the infarct segments than in the ischemic segments (56% vs 39%, P<0.01). The absolute magnitude of εpss, εpss/εsys, εpss/εmax were significantly larger and Tpss significantly longer in the ischemic and infarct segments compared with that in the normal myocardium (P<0.01).εpss/εsys, εpss/εmax were even larger and Tpss even longer in the infarct than in the ischemic segments (P<0.01).Conclusions PSS is a common and important feature of the ischemic and infarct myocardium. εpss, εpss/εsys, εpss/εmax and Tpss as measured by SRI may be promising markers for the quantitative assessment of regional myocardial dysfunction in patients with coronary artery disease. εpss/εsys, εpss/εmax and Tpss may be helpful in differentiating infarct from ischemic myocardium.

  19. Pre-power-stroke cross-bridges contribute to force transients during imposed shortening in isolated muscle fibers.

    Fabio C Minozzo

    Full Text Available When skeletal muscles are activated and mechanically shortened, the force that is produced by the muscle fibers decreases in two phases, marked by two changes in slope (P₁ and P₂ that happen at specific lengths (L₁ and L₂. We tested the hypothesis that these force transients are determined by the amount of myosin cross-bridges attached to actin and by changes in cross-bridge strain due to a changing fraction of cross-bridges in the pre-power-stroke state. Three separate experiments were performed, using skinned muscle fibers that were isolated and subsequently (i activated at different Ca²⁺ concentrations (pCa²⁺ 4.5, 5.0, 5.5, 6.0 (n = 13, (ii activated in the presence of blebbistatin (n = 16, and (iii activated in the presence of blebbistatin at varying velocities (n = 5. In all experiments, a ramp shortening was imposed (amplitude 10%L₀, velocity 1 L₀•sarcomere length (SL•s⁻¹, from an initial SL of 2.5 µm (except by the third group, in which velocities ranged from 0.125 to 2.0 L₀•s⁻¹. The values of P₁, P₂, L₁, and L₂ did not change with Ca²⁺ concentrations. Blebbistatin decreased P₁, and it did not alter P₂, L₁, and L₂. We developed a mathematical cross-bridge model comprising a load-dependent power-stroke transition and a pre-power-stroke cross-bridge state. The P₁ and P₂ critical points as well as the critical lengths L₁ and L₂ were explained qualitatively by the model, and the effects of blebbistatin inhibition on P₁ were also predicted. Furthermore, the results of the model suggest that the mechanism by which blebbistatin inhibits force is by interfering with the closing of the myosin upper binding cleft, biasing cross-bridges into a pre-power-stroke state.

  20. Pre-power-stroke cross-bridges contribute to force transients during imposed shortening in isolated muscle fibers.

    Minozzo, Fabio C; Hilbert, Lennart; Rassier, Dilson E


    When skeletal muscles are activated and mechanically shortened, the force that is produced by the muscle fibers decreases in two phases, marked by two changes in slope (P₁ and P₂) that happen at specific lengths (L₁ and L₂). We tested the hypothesis that these force transients are determined by the amount of myosin cross-bridges attached to actin and by changes in cross-bridge strain due to a changing fraction of cross-bridges in the pre-power-stroke state. Three separate experiments were performed, using skinned muscle fibers that were isolated and subsequently (i) activated at different Ca²⁺ concentrations (pCa²⁺ 4.5, 5.0, 5.5, 6.0) (n = 13), (ii) activated in the presence of blebbistatin (n = 16), and (iii) activated in the presence of blebbistatin at varying velocities (n = 5). In all experiments, a ramp shortening was imposed (amplitude 10%L₀, velocity 1 L₀•sarcomere length (SL)•s⁻¹), from an initial SL of 2.5 µm (except by the third group, in which velocities ranged from 0.125 to 2.0 L₀•s⁻¹). The values of P₁, P₂, L₁, and L₂ did not change with Ca²⁺ concentrations. Blebbistatin decreased P₁, and it did not alter P₂, L₁, and L₂. We developed a mathematical cross-bridge model comprising a load-dependent power-stroke transition and a pre-power-stroke cross-bridge state. The P₁ and P₂ critical points as well as the critical lengths L₁ and L₂ were explained qualitatively by the model, and the effects of blebbistatin inhibition on P₁ were also predicted. Furthermore, the results of the model suggest that the mechanism by which blebbistatin inhibits force is by interfering with the closing of the myosin upper binding cleft, biasing cross-bridges into a pre-power-stroke state.

  1. Velocities in Solar Pores

    Balasubramaniam, K. S.; Keil, S. L.; Smaldone, L. A.


    We investigate the three dimensional structure of solar pores and their surroundings using high spatial and spectral resolution data. We present evidence that surface velocities decrease around pores with a corresponding increase in the line-of-sight (LOS) velocities. LOS velocities in pores increase with the strength of the magnetic field. Surface velocities show convergence toward a weak downflow which appear to trace boundaries resembling meso-granular and super granular flows. The observed magnetic fields in the pores appear near these boundaries. We analyze the vertical velocity structure in pores and show that they generally have downflows decreasing exponentially with height, with a scale height of about 90 km. Evidence is also presented for the expanding nature of flux tubes. Finally we describe a phenomenological model for pores. This work was supported by AFOSR Task 2311G3. LAS was partially supported by the Progetto Nazionale Astrofisica e Fisica Cosmica of MURST and Scambi Internazionali of the Universita degli Studi di Napoli Frederico II. National Solar Observatory, NOAO, is operated for the National Science Foundation by AURA, Inc.

  2. Modeling the Maximum Spreading of Liquid Droplets Impacting Wetting and Nonwetting Surfaces.

    Lee, Jae Bong; Derome, Dominique; Guyer, Robert; Carmeliet, Jan


    Droplet impact has been imaged on different rigid, smooth, and rough substrates for three liquids with different viscosity and surface tension, with special attention to the lower impact velocity range. Of all studied parameters, only surface tension and viscosity, thus the liquid properties, clearly play a role in terms of the attained maximum spreading ratio of the impacting droplet. Surface roughness and type of surface (steel, aluminum, and parafilm) slightly affect the dynamic wettability and maximum spreading at low impact velocity. The dynamic contact angle at maximum spreading has been identified to properly characterize this dynamic spreading process, especially at low impact velocity where dynamic wetting plays an important role. The dynamic contact angle is found to be generally higher than the equilibrium contact angle, showing that statically wetting surfaces can become less wetting or even nonwetting under dynamic droplet impact. An improved energy balance model for maximum spreading ratio is proposed based on a correct analytical modeling of the time at maximum spreading, which determines the viscous dissipation. Experiments show that the time at maximum spreading decreases with impact velocity depending on the surface tension of the liquid, and a scaling with maximum spreading diameter and surface tension is proposed. A second improvement is based on the use of the dynamic contact angle at maximum spreading, instead of quasi-static contact angles, to describe the dynamic wetting process at low impact velocity. This improved model showed good agreement compared to experiments for the maximum spreading ratio versus impact velocity for different liquids, and a better prediction compared to other models in literature. In particular, scaling according to We(1/2) is found invalid for low velocities, since the curves bend over to higher maximum spreading ratios due to the dynamic wetting process.

  3. Freezing shortens the lifetime of DNA molecules under tension.

    Chung, Wei-Ju; Cui, Yujia; Chen, Chi-Shuo; Wei, Wesley H; Chang, Rong-Shing; Shu, Wun-Yi; Hsu, Ian C


    DNA samples are commonly frozen for storage. However, freezing can compromise the integrity of DNA molecules. Considering the wide applications of DNA molecules in nanotechnology, changes to DNA integrity at the molecular level may cause undesirable outcomes. However, the effects of freezing on DNA integrity have not been fully explored. To investigate the impact of freezing on DNA integrity, samples of frozen and non-frozen bacteriophage lambda DNA were studied using optical tweezers. Tension (5-35 pN) was applied to DNA molecules to mimic mechanical interactions between DNA and other biomolecules. The integrity of the DNA molecules was evaluated by measuring the time taken for single DNA molecules to break under tension. Mean lifetimes were determined by maximum likelihood estimates and variances were obtained through bootstrapping simulations. Under 5 pN of force, the mean lifetime of frozen samples is 44.3 min with 95% confidence interval (CI) between 36.7 min and 53.6 min while the mean lifetime of non-frozen samples is 133.2 min (95% CI: 97.8-190.1 min). Under 15 pN of force, the mean lifetimes are 10.8 min (95% CI: 7.6-12.6 min) and 78.5 min (95% CI: 58.1-108.9 min). The lifetimes of frozen DNA molecules are significantly reduced, implying that freezing compromises DNA integrity. Moreover, we found that the reduced DNA structural integrity cannot be restored using regular ligation process. These results indicate that freezing can alter the structural integrity of the DNA molecules.

  4. Telomere shortening in diaphragm and tibialis anterior muscles of aged mdx mice.

    Lund, Troy C; Grange, Robert W; Lowe, Dawn A


    The progression of Duchenne muscular dystrophy (DMD) is, in part, due to satellite cell senescence driven by high replicative pressure as these muscle stem cells repeatedly divide and fuse to damaged muscle fibers. We hypothesize that telomere shortening in satellite cells underlies their senescence. To test this hypothesis, we evaluated the diaphragm and a leg muscle from dystrophic mice of various ages for telomere dynamics. We found 30% telomere shortening in tibialis anterior muscles from 600-day-old mdx mice relative to age-matched wildtype mice. We also found a more severe shortening of telomere length in diaphragm muscles of old mdx mice. In those muscles, telomeres were shortened by approximately 15% and 40% in 100- and 600-day-old mdx mice, respectively. These findings indicate that satellite cells undergo telomere erosion, which may contribute to the inability of these cells to perpetually repair DMD muscle.

  5. Effects of running velocity on running kinetics and kinematics.

    Brughelli, Matt; Cronin, John; Chaouachi, Anis


    Sixteen semiprofessional Australian football players performed running bouts at incremental velocities of 40, 60, 80, and 100% of their maximum velocity on a Woodway nonmotorized force treadmill. As running velocity increased from 40 to 60%, peak vertical and peak horizontal forces increased by 14.3% (effect size [ES] = 1.0) and 34.4% (ES = 4.2), respectively. The changes in peak vertical and peak horizontal forces from 60 to 80% were 1.0% (ES = 0.05) and 21.0% (ES = 2.9), respectively. Finally, the changes in peak vertical and peak horizontal forces from 80% to maximum were 2.0% (ES = 0.1) and 24.3% (ES = 3.4). In addition, both stride frequency and stride length significantly increased with each incremental velocity (p velocity (p velocity (r = 0.47). For the kinematic variables, only stride length was found to have a significant positive correlation with maximum running velocity (r = 0.66). It would seem that increasing maximal sprint velocity may be more dependent on horizontal force production as opposed to vertical force production.

  6. Quantitative velocity modulation spectroscopy

    Hodges, James N.; McCall, Benjamin J.


    Velocity Modulation Spectroscopy (VMS) is arguably the most important development in the 20th century for spectroscopic study of molecular ions. For decades, interpretation of VMS lineshapes has presented challenges due to the intrinsic covariance of fit parameters including velocity modulation amplitude, linewidth, and intensity. This limitation has stifled the growth of this technique into the quantitative realm. In this work, we show that subtle changes in the lineshape can be used to help address this complexity. This allows for determination of the linewidth, intensity relative to other transitions, velocity modulation amplitude, and electric field strength in the positive column of a glow discharge. Additionally, we explain the large homogeneous component of the linewidth that has been previously described. Using this component, the ion mobility can be determined.

  7. The Maximum Density of Water.

    Greenslade, Thomas B., Jr.


    Discusses a series of experiments performed by Thomas Hope in 1805 which show the temperature at which water has its maximum density. Early data cast into a modern form as well as guidelines and recent data collected from the author provide background for duplicating Hope's experiments in the classroom. (JN)

  8. Abolishing the maximum tension principle

    Dabrowski, Mariusz P


    We find the series of example theories for which the relativistic limit of maximum tension $F_{max} = c^2/4G$ represented by the entropic force can be abolished. Among them the varying constants theories, some generalized entropy models applied both for cosmological and black hole horizons as well as some generalized uncertainty principle models.

  9. Abolishing the maximum tension principle

    Mariusz P. Da̧browski


    Full Text Available We find the series of example theories for which the relativistic limit of maximum tension Fmax=c4/4G represented by the entropic force can be abolished. Among them the varying constants theories, some generalized entropy models applied both for cosmological and black hole horizons as well as some generalized uncertainty principle models.

  10. Attempts to Shorten the Time of Lactic Fermentation by Ultrasonic Irradiation

    Masuzawa, Nobuyoshi; Ohdaira, Etsuzo


    In recent years, applications of ultrasound to food processing have been of interest. Fermentation is a typical example of food processing which has been used, since ancient times, on milk and is utilized for processing various dairy products, e.g., yoghurt. In this study, ultrasonic irradiation to shorten the time of fermentation in yoghurt production is attempted. It is proven that shortening the fermentation time is possible by employing ultrasonic irradiation.

  11. Kick velocity induced by magnetic dipole and quadrupole radiation

    Kojima, Yasufumi


    We examine the recoil velocity induced by the superposition of the magnetic dipole and quadrupole radiation from a pulsar/magnetar born with rapid rotation. The resultant velocity depends on not the magnitude, but rather the ratio of the two moments and their geometrical configuration. The model does not necessarily lead to high spatial velocity for a magnetar with a strong magnetic field, which is consistent with the recent observational upper bound. The maximum velocity predicted with this model is slightly smaller than that of observed fast-moving pulsars.

  12. Paintball velocity as a function of distance traveled

    Pat Chiarawongse


    Full Text Available The relationship between the distance a paintball travels through air and its velocity is investigated by firing a paintball into a ballistic pendulum from a range of distances. The motion of the pendulum was filmed and analyzed by using video analysis software. The velocity of the paintball on impact was calculated from the maximum horizontal displacement of the pendulum. It is shown that the velocity of a paintball decreases exponentially with distance traveled, as expected. The average muzzle velocity of the paint balls is found with an estimate of the drag coefficient

  13. Paintball velocity as a function of distance traveled

    Pat Chiarawongse


    Full Text Available The relationship between the distance a paintball travels through air and its velocity is investigated by firing a paintball into a ballistic pendulum from a range of distances. The motion of the pendulum was filmed and analyzed by using video analysis software. The velocity of the paintball on impact was calculated from the maximum horizontal displacement of the pendulum. It is shown that the velocity of a paintball decreases exponentially with distance traveled, as expected. The average muzzle velocity of the paint balls is found with an estimate of the drag coefficient.

  14. Note: A helical velocity selector for continuous molecular beams.

    Szewc, Carola; Collier, James D; Ulbricht, Hendrik


    We report on a modern realization of the classic helical velocity selector for gas phase particle beams. The device operates stably under high vacuum conditions at rotational frequencies limited only by commercial dc motor capabilities. Tuning the rotational frequency allows selective scanning over a broad velocity band. The width of the selected velocity distributions at full-width-half-maximum is as narrow as a few percent of the selected mean velocity and independent of the rotational speed of the selector. The selector generates low vibrational noise amplitudes comparable to mechanically damped state-of-the-art turbo-molecular pumps and is therefore compatible with vibration sensitive experiments like molecule interferometry.

  15. The Prescribed Velocity Method

    Nielsen, Peter Vilhelm

    The- velocity level in a room ventilated by jet ventilation is strongly influenced by the supply conditions. The momentum flow in the supply jets controls the air movement in the room and, therefore, it is very important that the inlet conditions and the numerical method can generate a satisfactory...... description of this momentum flow. The Prescribed Velocity Method is a practical method for the description of an Air Terminal Device which will save grid points close to the opening and ensure the right level of the momentum flow....

  16. Compression and Combining Based on Channel Shortening and Rank Reduction Technique for Cooperative Wireless Sensor Networks

    Ahmed, Qasim Zeeshan


    This paper investigates and compares the performance of wireless sensor networks where sensors operate on the principles of cooperative communications. We consider a scenario where the source transmits signals to the destination with the help of L sensors. As the destination has the capacity of processing only U out of these L signals, the strongest U signals are selected while the remaining (L?U) signals are suppressed. A preprocessing block similar to channel-shortening is proposed in this contribution. However, this preprocessing block employs a rank-reduction technique instead of channel-shortening. By employing this preprocessing, we are able to decrease the computational complexity of the system without affecting the bit error rate (BER) performance. From our simulations, it can be shown that these schemes outperform the channel-shortening schemes in terms of computational complexity. In addition, the proposed schemes have a superior BER performance as compared to channel-shortening schemes when sensors employ fixed gain amplification. However, for sensors which employ variable gain amplification, a tradeoff exists in terms of BER performance between the channel-shortening and these schemes. These schemes outperform channel-shortening scheme for lower signal-to-noise ratio.

  17. Experimental study on velocity characteristics of recirculation zone in humid air non-premixed flame


    To examine the effect of the flow field within the recirculation zone on flame structure,the characteristic velocity fields of methane/humid air flame in nonpremixed combustion behind a disc bluff-body burner were experimentally studied by particle image velocimeter (PIV).The results show that two stagnation points exist on the centerline in the recirculation zone flame.However,the distance of the two stagnation points in humid air combustion shortens,and the minimal dimensionless velocity increases compared with the conventional nonhumid air combustion.In addition,the positional curves of the minimal velocities can be partitioned into three phases representing three different flame patterns.The analysis of axial minimal velocities on the centerline and their positions under different co-flow air velocity conditions reveals that fuel-to-air velocity ratio is the crucial parameter that governs humid air combustion flame characteristics.

  18. Modeling Terminal Velocity

    Brand, Neal; Quintanilla, John A.


    Using a simultaneously falling softball as a stopwatch, the terminal velocity of a whiffle ball can be obtained to surprisingly high accuracy with only common household equipment. This classroom activity engages students in an apparently daunting task that nevertheless is tractable, using a simple model and mathematical techniques at their…

  19. Maximum Genus of Strong Embeddings

    Er-ling Wei; Yan-pei Liu; Han Ren


    The strong embedding conjecture states that any 2-connected graph has a strong embedding on some surface. It implies the circuit double cover conjecture: Any 2-connected graph has a circuit double cover.Conversely, it is not true. But for a 3-regular graph, the two conjectures are equivalent. In this paper, a characterization of graphs having a strong embedding with exactly 3 faces, which is the strong embedding of maximum genus, is given. In addition, some graphs with the property are provided. More generally, an upper bound of the maximum genus of strong embeddings of a graph is presented too. Lastly, it is shown that the interpolation theorem is true to planar Halin graph.

  20. D(Maximum)=P(Argmaximum)

    Remizov, Ivan D


    In this note, we represent a subdifferential of a maximum functional defined on the space of all real-valued continuous functions on a given metric compact set. For a given argument, $f$ it coincides with the set of all probability measures on the set of points maximizing $f$ on the initial compact set. This complete characterization lies in the heart of several important identities in microeconomics, such as Roy's identity, Sheppard's lemma, as well as duality theory in production and linear programming.

  1. The Testability of Maximum Magnitude

    Clements, R.; Schorlemmer, D.; Gonzalez, A.; Zoeller, G.; Schneider, M.


    Recent disasters caused by earthquakes of unexpectedly large magnitude (such as Tohoku) illustrate the need for reliable assessments of the seismic hazard. Estimates of the maximum possible magnitude M at a given fault or in a particular zone are essential parameters in probabilistic seismic hazard assessment (PSHA), but their accuracy remains untested. In this study, we discuss the testability of long-term and short-term M estimates and the limitations that arise from testing such rare events. Of considerable importance is whether or not those limitations imply a lack of testability of a useful maximum magnitude estimate, and whether this should have any influence on current PSHA methodology. We use a simple extreme value theory approach to derive a probability distribution for the expected maximum magnitude in a future time interval, and we perform a sensitivity analysis on this distribution to determine if there is a reasonable avenue available for testing M estimates as they are commonly reported today: devoid of an appropriate probability distribution of their own and estimated only for infinite time (or relatively large untestable periods). Our results imply that any attempt at testing such estimates is futile, and that the distribution is highly sensitive to M estimates only under certain optimal conditions that are rarely observed in practice. In the future we suggest that PSHA modelers be brutally honest about the uncertainty of M estimates, or must find a way to decrease its influence on the estimated hazard.

  2. Alternative Multiview Maximum Entropy Discrimination.

    Chao, Guoqing; Sun, Shiliang


    Maximum entropy discrimination (MED) is a general framework for discriminative estimation based on maximum entropy and maximum margin principles, and can produce hard-margin support vector machines under some assumptions. Recently, the multiview version of MED multiview MED (MVMED) was proposed. In this paper, we try to explore a more natural MVMED framework by assuming two separate distributions p1( Θ1) over the first-view classifier parameter Θ1 and p2( Θ2) over the second-view classifier parameter Θ2 . We name the new MVMED framework as alternative MVMED (AMVMED), which enforces the posteriors of two view margins to be equal. The proposed AMVMED is more flexible than the existing MVMED, because compared with MVMED, which optimizes one relative entropy, AMVMED assigns one relative entropy term to each of the two views, thus incorporating a tradeoff between the two views. We give the detailed solving procedure, which can be divided into two steps. The first step is solving our optimization problem without considering the equal margin posteriors from two views, and then, in the second step, we consider the equal posteriors. Experimental results on multiple real-world data sets verify the effectiveness of the AMVMED, and comparisons with MVMED are also reported.

  3. Diaphragm curvature modulates the relationship between muscle shortening and volume displacement.

    Greybeck, Brad J; Wettergreen, Matthew; Hubmayr, Rolf D; Boriek, Aladin M


    During physiological spontaneous breathing maneuvers, the diaphragm displaces volume while maintaining curvature. However, with maximal diaphragm activation, curvature decreases sharply. We tested the hypotheses that the relationship between diaphragm muscle shortening and volume displacement (VD) is nonlinear and that curvature is a determinant of such a relationship. Radiopaque markers were surgically placed on three neighboring muscle fibers in the midcostal region of the diaphragm in six dogs. The three-dimensional locations were determined using biplanar fluoroscopy and diaphragm VD, curvature, and muscle shortening were computed in the prone and supine postures during spontaneous breathing (SB), spontaneous inspiration efforts after airway occlusion at lung volumes ranging from functional residual capacity (FRC) to total lung capacity, and during bilateral maximal phrenic nerve stimulation at those same lung volumes. In supine dogs, diaphragm VD was approximately two- to three-fold greater during maximal phrenic nerve stimulation than during SB. The contribution of muscle shortening to VD nonlinearly increases with level of diaphragm activation independent of posture. During submaximal diaphragm activation, the contribution is essentially linear due to constancy of diaphragm curvature in both the prone and supine posture. However, the sudden loss of curvature during maximal bilateral phrenic nerve stimulation at muscle shortening values greater than 40% (ΔL/L(FRC)) causes a nonlinear increase in the contribution of muscle shortening to diaphragm VD, which is concomitant with a nonlinear change in diaphragm curvature. We conclude that the nonlinear relationship between diaphragm muscle shortening and its VD is, in part, due to a loss of its curvature at extreme muscle shortening.

  4. Wave propagation and group velocity

    Brillouin, Léon


    Wave Propagation and Group Velocity contains papers on group velocity which were published during the First World War and are missing in many libraries. It introduces three different definitions of velocities: the group velocity of Lord Rayleigh, the signal velocity of Sommerfeld, and the velocity of energy transfer, which yields the rate of energy flow through a continuous wave and is strongly related to the characteristic impedance. These three velocities are identical for nonabsorbing media, but they differ considerably in an absorption band. Some examples are discussed in the last chapter

  5. Early Cenozoic Shortening and Foreland Basin Sedimentation in the Marañon Fold-thrust Belt, Central Peruvian Andes

    Jackson, L. J.; Carlotto, V.; Horton, B. K.; Rosell, L. N.


    The Marañon fold-thrust belt in the westernmost Andes of Peru has long been considered a robust signature of early Cenozoic shortening in the Andean orogenic belt. However, the structural details and potential records of coeval synorogenic sedimentation remain elusive. We report results from new geologic mapping (1:50,000), cross-section construction, and U-Pb geochronology for the Matucana-Ticlio region at 11-12°S along the Lima-La Oroya highway. Zircon U-Pb age data from volcanic rocks and clastic basin fill provide a maximum depositional age of ~43 Ma for a middle Eocene syndeformational unit that we identify as the Anta Formation, which overlies the Paleocene Casapalca Formation. Sedimentary lithofacies and unconformable relationships within the volcaniclastic Anta Formation reveal mixed fluvial, alluvial-fan, and volcanic depositional conditions during shortening accommodated by a NE-verging thrust/reverse fault and corresponding backthrust (here named the Chonta fault system). Our cross-section reconstruction and geochronological data indicate that the region is a critical, possibly unique, zone of the broader NE-directed Marañon fold-thrust belt where pre-Neogene synorogenic sediments and their associated structures are preserved. We interpret this combined structural and basin system as an Eocene-age (Incaic) frontal thrust belt and corresponding foredeep to wedge-top depozone in central Peru. As one of the better-constrained segments of the Marañon fold-thrust belt, this zone provides insight into potential linkages with elusive early Cenozoic (Incaic) structures and foreland basin fill of the Western Cordillera and Altiplano farther south in the central Andean plateau.

  6. Radial Velocities with PARAS

    Roy, Arpita; Mahadevan, S.; Chakraborty, A.; Pathan, F. M.; Anandarao, B. G.


    The Physical Research Laboratory Advanced Radial-velocity All-sky Search (PARAS) is an efficient fiber-fed cross-dispersed high-resolution echelle spectrograph that will see first light in early 2010. This instrument is being built at the Physical Research laboratory (PRL) and will be attached to the 1.2m telescope at Gurushikhar Observatory at Mt. Abu, India. PARAS has a single-shot wavelength coverage of 370nm to 850nm at a spectral resolution of R 70000 and will be housed in a vacuum chamber (at 1x10-2 mbar pressure) in a highly temperature controlled environment. This renders the spectrograph extremely suitable for exoplanet searches with high velocity precision using the simultaneous Thorium-Argon wavelength calibration method. We are in the process of developing an automated data analysis pipeline for echelle data reduction and precise radial velocity extraction based on the REDUCE package of Piskunov & Valenti (2002), which is especially careful in dealing with CCD defects, extraneous noise, and cosmic ray spikes. Here we discuss the current status of the PARAS project and details and tests of the data analysis procedure, as well as results from ongoing PARAS commissioning activities.

  7. Cacti with maximum Kirchhoff index

    Wang, Wen-Rui; Pan, Xiang-Feng


    The concept of resistance distance was first proposed by Klein and Randi\\'c. The Kirchhoff index $Kf(G)$ of a graph $G$ is the sum of resistance distance between all pairs of vertices in $G$. A connected graph $G$ is called a cactus if each block of $G$ is either an edge or a cycle. Let $Cat(n;t)$ be the set of connected cacti possessing $n$ vertices and $t$ cycles, where $0\\leq t \\leq \\lfloor\\frac{n-1}{2}\\rfloor$. In this paper, the maximum kirchhoff index of cacti are characterized, as well...

  8. Generic maximum likely scale selection

    Pedersen, Kim Steenstrup; Loog, Marco; Markussen, Bo


    The fundamental problem of local scale selection is addressed by means of a novel principle, which is based on maximum likelihood estimation. The principle is generally applicable to a broad variety of image models and descriptors, and provides a generic scale estimation methodology. The focus...... on second order moments of multiple measurements outputs at a fixed location. These measurements, which reflect local image structure, consist in the cases considered here of Gaussian derivatives taken at several scales and/or having different derivative orders....

  9. Economics and Maximum Entropy Production

    Lorenz, R. D.


    Price differentials, sales volume and profit can be seen as analogues of temperature difference, heat flow and work or entropy production in the climate system. One aspect in which economic systems exhibit more clarity than the climate is that the empirical and/or statistical mechanical tendency for systems to seek a maximum in production is very evident in economics, in that the profit motive is very clear. Noting the common link between 1/f noise, power laws and Self-Organized Criticality with Maximum Entropy Production, the power law fluctuations in security and commodity prices is not inconsistent with the analogy. There is an additional thermodynamic analogy, in that scarcity is valued. A commodity concentrated among a few traders is valued highly by the many who do not have it. The market therefore encourages via prices the spreading of those goods among a wider group, just as heat tends to diffuse, increasing entropy. I explore some empirical price-volume relationships of metals and meteorites in this context.

  10. Applying the maximum information principle to cell transmission model of tra-ffic flow

    刘喜敏; 卢守峰


    This paper integrates the maximum information principle with the Cell Transmission Model (CTM) to formulate the velo-city distribution evolution of vehicle traffic flow. The proposed discrete traffic kinetic model uses the cell transmission model to cal-culate the macroscopic variables of the vehicle transmission, and the maximum information principle to examine the velocity distri-bution in each cell. The velocity distribution based on maximum information principle is solved by the Lagrange multiplier method. The advantage of the proposed model is that it can simultaneously calculate the hydrodynamic variables and velocity distribution at the cell level. An example shows how the proposed model works. The proposed model is a hybrid traffic simulation model, which can be used to understand the self-organization phenomena in traffic flows and predict the traffic evolution.

  11. Shortening of primary operators in N-extended $SCFT_{4}$ and harmonic-superspace analyticity

    Andrianopoli, Laura; Sokatchev, Emery S; Zupnik, B M


    We present the analysis of all possible shortenings which occur for composite gauge invariant conformal primary superfields in SU(2,2/N) invariant gauge theories. These primaries have top-spin range N/2 \\leq J_{max} < N with J_{max} = J_1 + J_2, (J_1,J_2) being the SL(2,C) quantum numbers of the highest spin component of the superfield. In Harmonic superspace, analytic and chiral superfields give J_{max}= N/2 series while intermediate shortenings correspond to fusion of chiral with analytic in N=2, or analytic with different analytic structures in N=3,4. In the AdS/CFT language shortenings of UIR's correspond to all possible BPS conditions on bulk states. An application of this analysis to multitrace operators, corresponding to multiparticle supergravity states, is spelled out.

  12. Assessment of muscle shortening and static posture in children with persistent asthma.

    Lopes, Erica A; Fanelli-Galvani, Adriana; Prisco, Camilla C V; Gonçalves, Raquel C; Jacob, Cristina M A; Cabral, Anna L B; Martins, Milton A; Carvalho, Celso R F


    Asthmatic patients experience an increase in airway resistance that overburdens both respiratory and non-respiratory muscles. The objective of the present study was to determine whether children with persistent asthma present muscle shortening and postural changes. The 60 boys evaluated, aged 7-12 (pubertal ages up to Tanner stage G2) were divided into three age- and BMI-matched groups of equal number: CON (no history of asthma or allergy); MPA (mild persistent asthma); SPA (severe persistent asthma). Pulmonary function, muscle shortening and static posture were evaluated. The SPA group presented higher protraction of the head and shoulder compared with the CON group [9.5 (6.0-12.0) degrees vs 5.5 (0.0-12.0) degrees, P control subjects in five out nine evaluated outcomes. Our data suggest that severe asthmatic children present postural adaptations and muscle shortening that seem to be related to disease severity.

  13. Conventional Point-Velocity Records and Surface Velocity Observations for Estimating High Flow Discharge

    Giovanni Corato


    Full Text Available Flow velocity measurements using point-velocity meters are normally obtained by sampling one, two or three velocity points per vertical profile. During high floods their use is inhibited due to the difficulty of sampling in lower portions of the flow area. Nevertheless, the application of standard methods allows estimation of a parameter, α, which depends on the energy slope and the Manning roughness coefficient. During high floods, monitoring of velocity can be accomplished by sampling the maximum velocity, umax, only, which can be used to estimate the mean flow velocity, um, by applying the linear entropy relationship depending on the parameter, M, estimated on the basis of historical observed pairs (um, umax. In this context, this work attempts to analyze if a correlation between α and M holds, so that the monitoring for high flows can be addressed by exploiting information from standard methods. A methodology is proposed to estimate M from α, by coupling the “historical” information derived by standard methods, and “new” information from the measurement of umax surmised at later times. Results from four gauged river sites of different hydraulic and geometric characteristics have shown the robust estimation of M based on α.

  14. Accelerated radial Fourier-velocity encoding using compressed sensing

    Hilbert, Fabian; Han, Dietbert [Wuerzburg Univ. (Germany). Inst. of Radiology; Wech, Tobias; Koestler, Herbert [Wuerzburg Univ. (Germany). Inst. of Radiology; Wuerzburg Univ. (Germany). Comprehensive Heart Failure Center (CHFC)


    Purpose:Phase Contrast Magnetic Resonance Imaging (MRI) is a tool for non-invasive determination of flow velocities inside blood vessels. Because Phase Contrast MRI only measures a single mean velocity per voxel, it is only applicable to vessels significantly larger than the voxel size. In contrast, Fourier Velocity Encoding measures the entire velocity distribution inside a voxel, but requires a much longer acquisition time. For accurate diagnosis of stenosis in vessels on the scale of spatial resolution, it is important to know the velocity distribution of a voxel. Our aim was to determine velocity distributions with accelerated Fourier Velocity Encoding in an acquisition time required for a conventional Phase Contrast image. Materials and Methods:We imaged the femoral artery of healthy volunteers with ECG - triggered, radial CINE acquisition. Data acquisition was accelerated by undersampling, while missing data were reconstructed by Compressed Sensing. Velocity spectra of the vessel were evaluated by high resolution Phase Contrast images and compared to spectra from fully sampled and undersampled Fourier Velocity Encoding. By means of undersampling, it was possible to reduce the scan time for Fourier Velocity Encoding to the duration required for a conventional Phase Contrast image. Results:Acquisition time for a fully sampled data set with 12 different Velocity Encodings was 40 min. By applying a 12.6 - fold retrospective undersampling, a data set was generated equal to 3:10 min acquisition time, which is similar to a conventional Phase Contrast measurement. Velocity spectra from fully sampled and undersampled Fourier Velocity Encoded images are in good agreement and show the same maximum velocities as compared to velocity maps from Phase Contrast measurements. Conclusion: Compressed Sensing proved to reliably reconstruct Fourier Velocity Encoded data. Our results indicate that Fourier Velocity Encoding allows an accurate determination of the velocity

  15. Transverse velocity shifts in protostellar jets: rotation or velocity asymmetries?

    De Colle, Fabio; Riera, Angels


    Observations of several protostellar jets show systematic differences in radial velocity transverse to the jet propagation direction, which have been interpreted as evidence of rotation in the jets. In this paper we discuss the origin of these velocity shifts, and show that they could be originated by rotation in the flow, or by side to side asymmetries in the shock velocity, which could be due to asymmetries in the jet ejection velocity/density or in the ambient medium. For typical poloidal jet velocities (~ 100-200 km/s), an asymmetry >~ 10% can produce velocity shifts comparable to those observed. We also present three dimensional numerical simulations of rotating, precessing and asymmetric jets, and show that, even though for a given jet there is a clear degeneracy between these effects, a statistical analysis of jets with different inclination angles can help to distinguish between the alternative origins of transverse velocity shifts. Our analysis indicate that side to side velocities asymmetries could ...

  16. Edentulism and shortened dental arch in Brazilian elderly from the National Survey of Oral Health 2003

    Marco Túlio Freitas Ribeiro


    Full Text Available OBJECTIVE: To describe the distribution of edentulism and estimate the prevalence of functional dentition and shortened dental arch among elderly population. METHODS: A population-based epidemiological study was carried out with a sample of 5,349 respondents aged 65 to 74 years obtained from the 2002 and 2003 Brazilian Ministry of Health/Division of Oral Health survey database. The following variables were studied: gender; macroregion of residence; missing teeth; percentage that met the World Health Organization goal for oral health in the age group 65 to 74 years (50% having at least 20 natural teeth; presence of shortened dental arch; number of posterior occluding pairs of teeth. The Chi-square test assessed the association between categorical variables. The Kruskal-Wallis and Mann-Whitney tests were used to assess differences of mean between number of posterior occluding pairs teeth, macro-region and gender. RESULTS: The elderly population had an average of 5.49 teeth (SD: 7.93 with a median of 0. The proportion of completely edentulous respondents was 54.7%. Complete edentulism was 18.2% in the upper arch and 1.9% in the lower arch. The World Health Organization goal was achieved in 10% of all respondents studied. However, only 2.7% had acceptable masticatory function and aesthetics (having at least shortened dental arch and a mean number of posterior occluding pairs of 6.94 (SD=2.97. There were significant differences of the percentage of respondents that met the World Health Organization goal and presence of shortened dental arch between men and women. There were differences in shortened dental arch between macroregions. CONCLUSIONS: The Brazilian epidemiological oral health survey showed high rate of edentulism and low rate of shortened dental arch in the elderly population studied, thus suggesting significant functional and aesthetic impairment in all Brazilian macroregions especially among women.

  17. Force depression following muscle shortening in sub-maximal voluntary contractions of human adductor pollicis.

    Rousanoglou, Elissavet N; Oskouei, Ali E; Herzog, Walter


    Mechanical properties of skeletal muscles are often studied for controlled, electrically induced, maximal, or supra-maximal contractions. However, many mechanical properties, such as the force-length relationship and force enhancement following active muscle stretching, are quite different for maximal and sub-maximal, or electrically induced and voluntary contractions. Force depression, the loss of force observed following active muscle shortening, has been observed and is well documented for electrically induced and maximal voluntary contractions. Since sub-maximal voluntary contractions are arguably the most important for everyday movement analysis and for biomechanical models of skeletal muscle function, it is important to study force depression properties under these conditions. Therefore, the purpose of this study was to examine force depression following sub-maximal, voluntary contractions. Sets of isometric reference and isometric-shortening-isometric test contractions at 30% of maximal voluntary effort were performed with the adductor pollicis muscle. All reference and test contractions were executed by controlling force or activation using a feedback system. Test contractions included adductor pollicis shortening over 10 degrees, 20 degrees, and 30 degrees of thumb adduction. Force depression was assessed by comparing the steady-state isometric forces (activation control) or average electromyograms (EMGs) (force control) following active muscle shortening with those obtained in the corresponding isometric reference contractions. Force was decreased by 20% and average EMG was increased by 18% in the shortening test contractions compared to the isometric reference contractions. Furthermore, force depression was increased with increasing shortening amplitudes, and the relative magnitudes of force depression were similar to those found in electrically stimulated and maximal contractions. We conclude from these results that force depression occurs in sub

  18. Crustal shortening and Eocene extension in the southeastern Canadian Cordillera: Some thermal and rheological considerations

    Liu, Mian; Furlong, Kevin P.


    Metamorphic core complexes in the southeastern Canadian Cordillera were formed during Eocene crustal extension, shortly (within a few millions of years) after Late Jurassic-Paleocene crustal shortening. Thermal-rheological modeling, constrained by geological and geochronological studies of the Valhalla core complex and other core complexes in this region, is used to investigate two major problems concerning the formation of these core complexes: (1) the dynamic links between crustal shortening and extension and (2) the cooling history and unroofing rates during extension. Thermal-rheological effects associated with crustal shortening are integrated through the history of crustal compression, since crustal shortening in this region was a long and slow process and cannot be treated as an instantaneous event. Our results suggest that crustal shortening may have played an important role in Eocene extension in the southeastern Canadian Cordillera by (1) producing a thickened and therefore unstable crust and (2) thermally weakening the lithosphere. However, heat generated by crustal shortening is not enough to account for the thermal state of the Valhalla complex, and additional heat sources at depth may be necessary. We then investigate thermal evolution during extension in both a simple shear model and a progressive pure stretching model. We show that the geotherm in an extensional region is time-and space-dependent and is affected by many variables including the preextensional thermal history and the mode of extension. Thus caution needs to be exercised when inferring unroofing rates from thermochronologic data. The cooling history of the Valhalla core complex may be explained by unroofing at rates of 1-2 mm/yr.

  19. Superimposed folding and thrusting by two phases of mutually orthogonal or oblique shortening in analogue models

    Deng, Hongling; Koyi, Hemin A.; Nilfouroushan, Faramarz


    Orogens may suffer more than one phase shortening resulting in superposition of structures of different generations. Superimposition of orthogonal or oblique shortening is studied using sandbox and centrifuge modelling. Results of sand models show that in orthogonal superimposition, the two resulting structural trends are approximately orthogonal to each other. In oblique superimposition, structures trend obliquely to each other in the relatively thin areas of the model (foreland), and mutually orthogonal in areas where the model is thickened during the first phase of shortening (i.e. the hinterland). Thrusts formed during the first shortening phase may be reactivated during the later shortening phase. Spacing of the later phase structures is not as wide as expected, considering they across the pre-existing thickened wedge. Superposition of structures results in formation of type 1 fold interference pattern. Bedding is curved outwards both in the dome and basin structures. Folded layers are dipping and plunging outwards in a dome, while they are dipping and plunging inwards in a basin. In the areas between two adjacent domes or basins (i.e. where an anticline is superimposed by a syncline or a syncline is superimposed by an anticline), bedding is curved inwards, and the anticlines plunge inwards and the synclines outwards. The latter feature could be helpful to determine the age relationship for type 2 fold interference pattern. In tectonic regions where multiple phases of shortening have occurred, the orogenic-scale dome-and-basin and arrowhead-shaped interference patterns are commonly formed, as in the models. However, in some areas, the fold interference pattern might be modified by a later phase of thrusting. Similar to models results, superimposition of two and/or even more deformation phases may not be recorded by structures all over the tectonic area.

  20. Shortening rates across the foothills of the Western Kunlun (Xinjiang, China) inferred from geomorphic measurements and cosmogenic 10Be dating.

    Coudroy, T.; van der Woerd, J.; Li, H.; Barrier, L.; Tapponnier, P.; Simoes, M.; Thuizat, R.; Pan, J.; Si, J.; Xu, T.


    The Western Kunlun, which bounds north-western Tibetan Plateau, is one of the largest mountain range of Asia, with altitudes peaking at 6500-7500 m asl, and crustal thicknesses of up to ~70 km. North of the plateau, in the foreland of the range, an active fold-and-thrust belt extends 200 km into the Tarim basin, but remains poorly documented regarding amounts of shortening or deformation rates. We discuss the distribution of deformation on the basis of a study of specific foreland folds and faults using high resolution satellite imagery, digital elevation models, seismic reflection data, on-site topographic measurements and cosmogenic isotope dating. South of Hotan city, the 250 km-long Tekelike Fault - the mountain-front thrust that dips beneath the 45 km-wide, 5400m-high Tekelike Range, a basement ramp-anticline - cuts and offsets terraces abandoned by the Karakash River. 10Be concentrations of surface and sub-surface samples from these terraces upper-most deposits yield an exposure age of about 100 kyr for the upper terrace that lies 140 m above the present river bed, implying an incision rate of 1.4 mm/yr. Assuming a dip of 45 +/-15° and neglecting changes in river dynamics over this time period, this age would imply a minimum, average shortening rate of 1.4 +/- 0.7 mm/yr across the thrust. Farther North, 100 to 200 km-long WNW-ESE trending anticlines deform the thick Tertiary and Quaternary sedimentary series lying in the foreland of the range. The 150 km-long, 35 km-wide Yecheng-Pishan anticline folds Plio-Quaternary molasses. Drainages crossing this growing anticline have abandoned flights of inset terraces on the sides of wind-gaps. The maximum elevation of the highest terrace above local drainage is about 350m. Near Pishan city, flat, well-preserved terrace surfaces are covered by thin loess, in turn capped by loose gravel pavement. On the uppermost two terraces of this valley, 70 and 120 meters-high, cosmogenic 10Be concentrations in surface and sub

  1. A generalized transport-velocity formulation for smoothed particle hydrodynamics

    Zhang, Chi; Hu, Xiangyu Y., E-mail:; Adams, Nikolaus A.


    The standard smoothed particle hydrodynamics (SPH) method suffers from tensile instability. In fluid-dynamics simulations this instability leads to particle clumping and void regions when negative pressure occurs. In solid-dynamics simulations, it results in unphysical structure fragmentation. In this work the transport-velocity formulation of Adami et al. (2013) is generalized for providing a solution of this long-standing problem. Other than imposing a global background pressure, a variable background pressure is used to modify the particle transport velocity and eliminate the tensile instability completely. Furthermore, such a modification is localized by defining a shortened smoothing length. The generalized formulation is suitable for fluid and solid materials with and without free surfaces. The results of extensive numerical tests on both fluid and solid dynamics problems indicate that the new method provides a unified approach for multi-physics SPH simulations.

  2. Objects of maximum electromagnetic chirality

    Fernandez-Corbaton, Ivan


    We introduce a definition of the electromagnetic chirality of an object and show that it has an upper bound. The upper bound is attained if and only if the object is transparent for fields of one handedness (helicity). Additionally, electromagnetic duality symmetry, i.e. helicity preservation upon scattering, turns out to be a necessary condition for reciprocal scatterers to attain the upper bound. We use these results to provide requirements for the design of such extremal scatterers. The requirements can be formulated as constraints on the polarizability tensors for dipolar scatterers or as material constitutive relations. We also outline two applications for objects of maximum electromagnetic chirality: A twofold resonantly enhanced and background free circular dichroism measurement setup, and angle independent helicity filtering glasses.

  3. Maximum mutual information regularized classification

    Wang, Jim Jing-Yan


    In this paper, a novel pattern classification approach is proposed by regularizing the classifier learning to maximize mutual information between the classification response and the true class label. We argue that, with the learned classifier, the uncertainty of the true class label of a data sample should be reduced by knowing its classification response as much as possible. The reduced uncertainty is measured by the mutual information between the classification response and the true class label. To this end, when learning a linear classifier, we propose to maximize the mutual information between classification responses and true class labels of training samples, besides minimizing the classification error and reducing the classifier complexity. An objective function is constructed by modeling mutual information with entropy estimation, and it is optimized by a gradient descend method in an iterative algorithm. Experiments on two real world pattern classification problems show the significant improvements achieved by maximum mutual information regularization.

  4. Distal femoral shortening in total hip arthroplasty for complex primary hip reconstruction. A new surgical technique.

    Koulouvaris, Panagiotis; Stafylas, Kosmas; Sculco, Thomas; Xenakis, Theodore


    Successful total hip arthroplasty (THA) in congenital dislocated hips demands anatomical reduction in the normal center of rotation without overstretching the sciatic nerve and without excessive compression or abnormal forces across the joint. Proximal femoral and subtrochanteric shortening osteotomy has been described for THA for the treatment of dislocated hips. However, these osteotomies are demanding, associated with deformation of femoral canal and nonunion, and may increase the femoral stem stress. This study reports excellent results in 24 patients with a new surgical technique that combines THA with a distal femoral shortening in severely deformed hips using customized components.

  5. Energy cost of isometric force production after active shortening in skinned muscle fibres.

    Joumaa, V; Fitzowich, A; Herzog, W


    The steady state isometric force after active shortening of a skeletal muscle is lower than the purely isometric force at the corresponding length. This property of skeletal muscle is known as force depression. The purpose of this study was to investigate whether the energy cost of force production at the steady state after active shortening was reduced compared to the energy cost of force production for a purely isometric contraction performed at the corresponding length (same length, same activation). Experiments were performed in skinned fibres isolated from rabbit psoas muscle. Skinned fibres were actively shortened from an average sarcomere length of 3.0 µm to an average sarcomere length of 2.4 µm. Purely isometric reference contractions were performed at an average sarcomere length of 2.4 µm. Simultaneously with the force measurements, the ATP cost was measured during the last 30 seconds of isometric contractions using an enzyme-coupled assay. Stiffness was calculated during a quick stretch-release cycle of 0.2% fibre length performed once the steady state had been reached after active shortening and during the purely isometric reference contractions. Force and stiffness following active shortening were decreased by 10.0±1.8% and 11.0±2.2%, respectively compared to the isometric reference contractions. Similarly, ATPase activity per second (not normalized to the force) showed a decrease of 15.6±3.0% in the force depressed state compared to the purely isometric reference state. However, ATPase activity per second per unit of force was similar for the isometric contractions following active shortening (28.7±2.4 mM/ and the corresponding purely isometric reference contraction (30.9±2.8 mM/ Furthermore, the reduction in absolute ATPase activity per second was significantly correlated with force depression and stiffness depression. These results are in accordance with the idea that force depression following active shortening is

  6. Markers of cellular senescence. Telomere shortening as a marker of cellular senescence.

    Bernadotte, Alexandra; Mikhelson, Victor M; Spivak, Irina M


    The cellular senescence definition comes to the fact of cells irreversible proliferation disability. Besides the cell cycle arrest, senescent cells go through some morphological, biochemical, and functional changes which are the signs of cellular senescence. The senescent cells (including replicative senescence and stress-induced premature senescence) of all the tissues look alike. They are metabolically active and possess the set of characteristics in vitro and in vivo, which are known as biomarkers of aging and cellular senescence. Among biomarkers of cellular senescence telomere shortening is a rather elegant frequently used biomarker. Validity of telomere shortening as a marker for cellular senescence is based on theoretical and experimental data.

  7. Telomere shortening correlates to dysplasia but not to DNA aneuploidy in longstanding ulcerative colitis

    Friis-Ottessen, Mariann; Bendix, Laila; Kølvraa, Steen;


    Ulcerative colitis (UC) is a chronic, inflammatory bowel disease which may lead to dysplasia and adenocarcinoma in patients when long-lasting. Short telomeres have been reported in mucosal cells of UC patients. Telomeres are repetitive base sequences capping the ends of linear chromosomes......, and protect them from erosion and subsequent wrongful recombination and end-to-end joining during cell division. Short telomeres are associated with the development of chromosomal instability and aneuploidy, the latter being risk factors for development of dysplasia and cancer. Specifically, the abrupt...... shortening of one or more telomeres to a critical length, rather than bulk shortening of telomeres, seems to be associated with chromosomal instability....

  8. The strong maximum principle revisited

    Pucci, Patrizia; Serrin, James

    In this paper we first present the classical maximum principle due to E. Hopf, together with an extended commentary and discussion of Hopf's paper. We emphasize the comparison technique invented by Hopf to prove this principle, which has since become a main mathematical tool for the study of second order elliptic partial differential equations and has generated an enormous number of important applications. While Hopf's principle is generally understood to apply to linear equations, it is in fact also crucial in nonlinear theories, such as those under consideration here. In particular, we shall treat and discuss recent generalizations of the strong maximum principle, and also the compact support principle, for the case of singular quasilinear elliptic differential inequalities, under generally weak assumptions on the quasilinear operators and the nonlinearities involved. Our principal interest is in necessary and sufficient conditions for the validity of both principles; in exposing and simplifying earlier proofs of corresponding results; and in extending the conclusions to wider classes of singular operators than previously considered. The results have unexpected ramifications for other problems, as will develop from the exposition, e.g. two point boundary value problems for singular quasilinear ordinary differential equations (Sections 3 and 4); the exterior Dirichlet boundary value problem (Section 5); the existence of dead cores and compact support solutions, i.e. dead cores at infinity (Section 7); Euler-Lagrange inequalities on a Riemannian manifold (Section 9); comparison and uniqueness theorems for solutions of singular quasilinear differential inequalities (Section 10). The case of p-regular elliptic inequalities is briefly considered in Section 11.

  9. Dark Matter Velocity Spectroscopy.

    Speckhard, Eric G; Ng, Kenny C Y; Beacom, John F; Laha, Ranjan


    Dark matter decays or annihilations that produce linelike spectra may be smoking-gun signals. However, even such distinctive signatures can be mimicked by astrophysical or instrumental causes. We show that velocity spectroscopy-the measurement of energy shifts induced by relative motion of source and observer-can separate these three causes with minimal theoretical uncertainties. The principal obstacle has been energy resolution, but upcoming experiments will have the precision needed. As an example, we show that the imminent Astro-H mission can use Milky Way observations to separate possible causes of the 3.5-keV line. We discuss other applications.

  10. Dark Matter Velocity Spectroscopy

    Speckhard, Eric G; Beacom, John F; Laha, Ranjan


    Dark matter decays or annihilations that produce line-like spectra may be smoking-gun signals. However, even such distinctive signatures can be mimicked by astrophysical or instrumental causes. We show that velocity spectroscopy-the measurement of energy shifts induced by relative motion of source and observer-can separate these three causes with minimal theoretical uncertainties. The principal obstacle has been energy resolution, but upcoming and proposed experiments will make significant improvements. As an example, we show that the imminent Astro-H mission can use Milky Way observations to separate possible causes of the 3.5-keV line. We discuss other applications.

  11. The velocity-depth ambiguity in seismic traveltime data

    Ross, W.S. (Exxon Production Research Co., Houston, TX (United States))


    An observed disturbance in seismic traveltimes to a reflector can be caused either by an anomalous velocity zone between the surface and the reflector or by a structural variation in the reflector itself. This velocity-depth ambiguity is formulated in terms of linear estimation theory. Such a formulation allows integration of various published results in velocity-depth ambiguity and suggests improved methods of stabilizing the solution of a depth-conversion problem. By solving a relatively simple problem that is amenable to analysis -- a single reflector beneath an overburden with a variable velocity -- the following conclusions can be drawn: (1) The velocity-depth ambiguity is caused by traveltime errors and can be quantitatively related to those errors by closed-form expressions if the velocities do not vary laterally. Among other things, those expressions show that for small spread lengths (shorter than half the depth) the errors in velocity and depth are inversely proportional to the square of the spread length. Errors can thus be reduced more effectively at small spread lengths by increasing the maximum offset rather than by including more offsets. Laterally varying velocities can be estimated accurately at all but isolated points in their spatial frequency spectrum, called ''wavelengths of maximum ambiguity.'' If these ambiguous wavelengths are stabilized by damping them rather than by more traditional lateral smoothing techniques, structural or velocity features smaller than a spread length need not be smeared laterally. (3) A deep velocity anomaly is estimated with lower accuracy than is a shallow one. The theory presented here is a complement to more general methods of velocity inversion, such as tomography, which can be used to solve very complex problems beyond the scope of this analysis.

  12. Shortening filtrations

    ENOCHS Edgar E.


    Let C be a set of modules.We argue that there is an ordinal κ such that if a module has a filtration by modules in C,then it has a filtration of length κ by direct sums of modules in C.As an application we give another way to prove a result of Saorín and (S)(t)oví(c)ek and of (S)(t)oví(c)ek.

  13. Velocity centroids as tracers of the turbulent velocity statistics

    Lazarian, A E A


    We use the results of magnetohydrodynamic (MHD) simulations to emulate spectroscopic observations, and produce maps of variations of velocity centroids to study their scaling properties. We compare them with those of the underlying velocity field, and analytic predictions presented in a previous paper (Lazarian & Esquivel 2003). We tested, with success, a criteria for recovering velocity statistics from velocity centroids derived in our previous work. That is, if >> (where S is a 2D map of ``unnormalized'', v velocity, and I integrated intensity map -column density-), then the structure function of the centroids is dominated by the structure function of velocity. We show that it is possible to extract the velocity statistics using centroids for subsonic and mildly supersonic turbulence (e.g. Mach numbers ~2.5). While, towards higher Mach numbers other effects could affect significantly the statistics of centroids.

  14. Statistics of Velocity from Spectral Data Modified Velocity Centroids

    Lazarian, A


    We address the problem of studying interstellar (ISM) turbulence using spectral line data. We construct a measure that we term modified velocity centroids (MVCs) and derive an analytical solution that relates the 2D spectra of the modified centroids with the underlying 3D velocity spectrum. We test our results using synthetic maps constructed with data obtained through simulations of compressible MHD turbulence. We prove that the MVCs are able to restore the underlying spectrum of turbulent velocity. We show that the modified velocity centroids (MVCs) are complementary to the the Velocity Channel Analysis (VCA) technique that we introduced earlier. Employed together they make determining of the velocity spectral index more reliable. At the same time we show that MVCs allow to determine velocity spectra when the underlying statistics is not a power law and/or the turbulence is subsonic.

  15. Maximum entropy production in daisyworld

    Maunu, Haley A.; Knuth, Kevin H.


    Daisyworld was first introduced in 1983 by Watson and Lovelock as a model that illustrates how life can influence a planet's climate. These models typically involve modeling a planetary surface on which black and white daisies can grow thus influencing the local surface albedo and therefore also the temperature distribution. Since then, variations of daisyworld have been applied to study problems ranging from ecological systems to global climate. Much of the interest in daisyworld models is due to the fact that they enable one to study self-regulating systems. These models are nonlinear, and as such they exhibit sensitive dependence on initial conditions, and depending on the specifics of the model they can also exhibit feedback loops, oscillations, and chaotic behavior. Many daisyworld models are thermodynamic in nature in that they rely on heat flux and temperature gradients. However, what is not well-known is whether, or even why, a daisyworld model might settle into a maximum entropy production (MEP) state. With the aim to better understand these systems, this paper will discuss what is known about the role of MEP in daisyworld models.

  16. Maximum stellar iron core mass

    F W Giacobbe


    An analytical method of estimating the mass of a stellar iron core, just prior to core collapse, is described in this paper. The method employed depends, in part, upon an estimate of the true relativistic mass increase experienced by electrons within a highly compressed iron core, just prior to core collapse, and is significantly different from a more typical Chandrasekhar mass limit approach. This technique produced a maximum stellar iron core mass value of 2.69 × 1030 kg (1.35 solar masses). This mass value is very near to the typical mass values found for neutron stars in a recent survey of actual neutron star masses. Although slightly lower and higher neutron star masses may also be found, lower mass neutron stars are believed to be formed as a result of enhanced iron core compression due to the weight of non-ferrous matter overlying the iron cores within large stars. And, higher mass neutron stars are likely to be formed as a result of fallback or accretion of additional matter after an initial collapse event involving an iron core having a mass no greater than 2.69 × 1030 kg.

  17. Maximum Matchings via Glauber Dynamics

    Jindal, Anant; Pal, Manjish


    In this paper we study the classic problem of computing a maximum cardinality matching in general graphs $G = (V, E)$. The best known algorithm for this problem till date runs in $O(m \\sqrt{n})$ time due to Micali and Vazirani \\cite{MV80}. Even for general bipartite graphs this is the best known running time (the algorithm of Karp and Hopcroft \\cite{HK73} also achieves this bound). For regular bipartite graphs one can achieve an $O(m)$ time algorithm which, following a series of papers, has been recently improved to $O(n \\log n)$ by Goel, Kapralov and Khanna (STOC 2010) \\cite{GKK10}. In this paper we present a randomized algorithm based on the Markov Chain Monte Carlo paradigm which runs in $O(m \\log^2 n)$ time, thereby obtaining a significant improvement over \\cite{MV80}. We use a Markov chain similar to the \\emph{hard-core model} for Glauber Dynamics with \\emph{fugacity} parameter $\\lambda$, which is used to sample independent sets in a graph from the Gibbs Distribution \\cite{V99}, to design a faster algori...

  18. Matters which shorten the ozone layer; Substances qui appauvrissent la couche d'ozone



    This document, proposed by the ministry of the national development and the environment, gives the list of the main texts relative to the matters which shorten the ozone layer and the evolution of the community regulations in this domain. The concerned matters are the Cfc and the HCFC production and use. (A.L.B.)

  19. [The concentration of growth factors in patients with inherent and acquired shortenings of limbs bones].

    Strogov, M V; Luneva, S N; Novikov, K I


    The article deals with the results of study of level of growth factors in blood serum of patients with inherent and post-traumatic shortenings of limbs' bones. The detection in blood serum the level of epidermal growth factor insulin-like growth factor I and angiopoetins is proposed to monitor in given patients the reparative bone formation.

  20. The addition of lidocaine to bupivacaine does not shorten the duration of spinal anesthesia

    Jacobsen, Jon; Husum, Bent; Staffeldt, Henrik


    The duration of spinal anesthesia with bupivacaine is often too long for day surgery. A recent study of patients presenting for transurethral surgery suggested that the addition of a small amount of lidocaine to intrathecal hyperbaric bupivacaine could shorten the duration of the sensory and motor...

  1. Decayed/missing/filled teeth and shortened dental arches in Tanzanian adults.

    Sarita, P.T.N.; Witter, D.J.; Kreulen, C.M.; Matee, M.I.N.; Hof, M.A. van 't; Creugers, N.H.J.


    PURPOSE: This study assessed decayed/missing/filled teeth (DMFT), presence of occlusal units, and prevalence of shortened dental arches in a Tanzanian adult population. MATERIALS AND METHODS: The dental state of samples of the Tanzanian population was studied. Oral examinations were conducted on

  2. Self-regulation by the Dutch medical profession of medical behavior that potentially shortens life

    Griffiths, John; Krabbendam, H.; Ten Napel, H.M.


    One of the most striking features of the way in which the Dutch have gone about regulating euthanasia and other "medical behavior that potentially shortens Life (MBPS) the key role that self-regulation has played in the process of legal development.' The rules and procedures that govern euthanasia

  3. Recovery time of motor evoked potentials following lengthening and shortening muscle action in the tibialis anterior

    Tallent, J.; Goodall, S.; Hortobagyi, T.; Gibson, A. St Clair; French, D. N.; Howatson, G.


    Motor evoked potentials (MEP) at rest remain facilitated following an isometric muscle contraction. Because the pre-synaptic and post-synaptic control of shortening (SHO) and lengthening (LEN) contractions differs, the possibility exists that the recovery of the MEP is also task specific. The time c

  4. Corrective osteotomy for malunion of the distal radius - The effect of concomitant ulnar shortening osteotomy

    Oskam, J; Bongers, KM; Karthaus, AJM; Frima, AJ; Klasen, HJ


    Positive ulnar variance due to inadequate correction of radial length is a common disorder after radial corrective osteotomy. To avoid this complication we performed a combination of ulnar-shortening osteotomy and radial corrective osteotomy in 6 of 22 radial corrections. The indication for the comb

  5. Ulnar Shortening Osteotomy After Distal Radius Fracture Malunion: Review of Literature

    Barbaric, Katarina; Rujevcan, Gordan; Labas, Marko; Delimar, Domagoj; Bicanic, Goran


    Malunion of distal radius fracture is often complicated with shortening of the radius with disturbed radio- ulnar variance, frequently associated with lesions of triangular fibrocartilage complex and instability of the distal radioulnar joint. Positive ulnar variance may result in wrist pain located in ulnar part of the joint, limited ulnar deviation and forearm rotation with development of degenerative changes due to the overloading that occurs between the ulnar head and corresponding carpus. Ulnar shortening osteotomy (USO) is the standard procedure for correcting positive ulnar variance. Goal of this procedure is to minimize the symptoms by restoring the neutral radio - ulnar variance. In this paper we present a variety of surgical techniques available for ulnar shorthening osteotomy, their advantages and drawbacks. Methods of ulnar shortening osteotomies are divided into intraarticular and extraarticular. Intraarticular method of ulnar shortening can be performed arthroscopically or through open approach. Extraarticular methods include subcapital osteotomy and osteotomy of ulnar diaphysis, which depending on shape can be transverse, oblique, and step cut. All of those osteotomies can be performed along wrist arthroscopy in order to dispose and treat possibly existing triangular fibrocartilage complex injuries. At the end we described surgical procedures that can be done in case of ulnar shorthening osteotomy failure. PMID:26157524

  6. Interlayer material transport during layer-normal shortening. Part I. The model

    Molen, I. van der


    To analyse mass-transfer during deformation, the case is considered of a multilayer experiencing a layer-normal shortening that is volume constant on the scale of many layers. Strain rate is homogeneously distributed on the layer-scale if diffusion is absent; when transport of matter between the

  7. Common Patterns of Congenital Lower Extremity Shortening: Diagnosis, Classification, and Follow-up.

    Bedoya, Maria A; Chauvin, Nancy A; Jaramillo, Diego; Davidson, Richard; Horn, B David; Ho-Fung, Victor


    Congenital lower limb shortening is a group of relatively rare, heterogeneous disorders. Proximal focal femoral deficiency (PFFD) and fibular hemimelia (FH) are the most common pathologic entities in this disease spectrum. PFFD is characterized by variable degrees of shortening or absence of the femoral head, with associated dysplasia of the acetabulum and femoral shaft. FH ranges from mild hypoplasia to complete absence of the fibula with variable shortening of the tibia. The development of the lower limb requires complex and precise gene interactions. Although the etiologies of PFFD and FH remain unknown, there is a strong association between the two disorders. Associated congenital defects in the lower extremity are found in more than 50% of patients with PFFD, ipsilateral FH being the most common. FH also has a strong association with shortening and bowing of the tibia and with foot deformities such as absence of the lateral rays of the foot. Early diagnosis and radiologic classification of these abnormalities are imperative for appropriate management and surgical planning. Plain radiography remains the main diagnostic imaging modality for both PFFD and FH, and appropriate description of the osseous abnormalities seen on radiographs allows accurate classification, prognostic evaluation, and surgical planning. Minor malformations may commonly be misdiagnosed.

  8. Crossbridge and non-crossbridge contributions to force in shortening and lengthening muscle.

    Ranatunga, K W; Roots, H; Pinniger, G J; Offer, G W


    Analysis of tension responses to ramp length changes in muscle can provide important information about the crossbridge cycle. During a ramp length change, the force response of an active muscle shows an early change in slope (the P₁ transition) followed by a later, gradual change in slope (the P₂ transition). Modeling shows that the first transition reflects the tension change associated with the crossbridge power stroke in shortening and with its reversal in lengthening; the reduction in slope at the second transition occurs when most of the crossbridges (myosin heads) that were attached at the start of the ramp become detached; the steady tension during shortening is borne mainly by post-stroke heads whereas tension during lengthening is borne mostly by pre-stroke heads. After the P₂ transition, the tension reaches a steady level in the model whereas in the experiments the tension continues to increase during lengthening or to decrease during shortening; this tension change is seen at a wide range of sarcomere lengths and even when active force is reduced by a myosin inhibitor. It appears that some non-crossbridge components in muscle fibers stiffen upon activation and contribute to the continued tension rise during lengthening; release of such tension leads to tension decline during shortening. Thus, non-crossbridge visco-elasticity in sarcomeres may also contribute to energy storage and release during in situ muscle function.

  9. Contribution of NHE-1 to cell length cardiac shortening of normal and failing rabbit myocytes

    M.M.G.J. van Borren; J.G. Zegers; A. Baartscheer; J.H. Ravesloot


    At the same intracellular pH (pH(i)) Na+/H+ exchange (NHE-1) fluxes of ventricular myocytes of hypertrophied failing hearts (HFH) are increased. We assessed how NHE-1 affected cell length shortening. pH(i) was measured fluorimetrically in resting and twitching (1 - 3 Hz)normal and HFH rabbit myocyte

  10. Changing Quality Controls: The Effects of Increasing Product Variety and Shortening Product Life Cycles

    J.D. van Iwaarden (Jos)


    textabstractIn many industries (e.g. cars, electronics, clothing) manufacturing complexity and unpredictability have increased in recent years because of increasing product variety and shortening product life cycles. At the same time, manufacturers in these industries appear to have more problems wi

  11. The Shortened Visuospatial Questionnaire for Children: A Useful Tool to Identify Students with Low Visuospatial Abilities

    Fastame, Maria Chiara; Cherchi, Rossella; Penna, Maria Pietronilla


    The current research was aimed mainly at exploring the reliability of a short-screening tool developed to self-evaluate visuospatial abilities in children. We presented 290 Italian third, fourth, and fifth graders with the 16-item Shortened Visuospatial questionnaire and several objective measures of intellectual efficiency, such as Raven's…




    A shortened histamine challenge test was used in a study of occupational airway disease. We evaluated the safety, defined as the absence of a decrease in forced expiratory volume in one second (FEV1) of greater than 40%. The occurrence of complaints, the repeatability of test results, and the averag

  13. Stochastic modeling of length-dependent telomere shortening in Corvus monedula

    Grasman, J.; Salomons, H. M.; Verhulst, S.


    It was recently shown that, within individuals, longer telomeres shorten at a higher rate. This explorative study deals with a mathematical model of this process. It is a nonlinear differential equation describing length-dependent decrease that can be linked to a Poisson process. The model also take

  14. Stochastic modelling of length-dependent telomere shortening in Corvus monedula

    Grasman, J.; Salomons, H.M.; Verhulst, S.


    It was recently shown that, within individuals, longer telomeres shorten at a higher rate. This explorative study deals with a mathematical model of this process. It is a nonlinear differential equation describing length-dependent decrease that can be linked to a Poisson process. The model also take

  15. Shortening full-length aptamer by crawling base deletion – Assisted by Mfold web server application

    Subash C.B. Gopinath


    Full Text Available Systematic Evolution of Ligands by EXponential enrichment (SELEX is the method to select the specific aptamer against a wide range of targets. For this process, the initial library usually has a length of random sequences from ∼25 and it reaches over 100 bases. The lengthy sequences have disadvantages such as difficult to prepare, less stable and expensive. It is wise to prefer shorter version of aptamer for a wide range of applications including drug delivery process. It is a common practice to shorten the full-length aptamer by mapping analyses and it is tedious. Here, we used a crawling method to shorten the aptamer by different sequential deletion of bases from both 5′ and 3′ ends, assisted by Mfold web server application. Two different kinds of aptamer with varied lengths (randomized region of 30 and 74 bases were desired for this study, generated against Influenza A/Panama/2007/1999 (H3N2 and gD protein of Herpes Simplex Virus-1. It was found that shortening the aptamer length by crawling pattern is possible with the assistance of Mfold web server application. The obtained results resemble the shortened aptamer derived by mapping analyses. The proposed strategy is recommended to predict the shorter aptamer without involving any wet experimental section.

  16. Decayed/missing/filled teeth and shortened dental arches in Tanzanian adults.

    Sarita, P.T.N.; Witter, D.J.; Kreulen, C.M.; Matee, M.I.N.; Hof, M.A. van 't; Creugers, N.H.J.


    PURPOSE: This study assessed decayed/missing/filled teeth (DMFT), presence of occlusal units, and prevalence of shortened dental arches in a Tanzanian adult population. MATERIALS AND METHODS: The dental state of samples of the Tanzanian population was studied. Oral examinations were conducted on 5,5

  17. Regional myocardial shortening in relation to graft-reactive hyperemia and flow after coronary bypass surgery

    R.W. Brower (Ronald); P.W.J.C. Serruys (Patrick); E. Bos (Egbert); J. Nauta (Jan)


    textabstractExtent of regional shortening of myocardium in areas newly perfused by bypass grafting was determined in 56 patients by a new technique employing four to six radiopaque markers sutured in pairs to the epicardium near the coronary anastomosis. Paradoxical systolic expansion (PSE) was mani

  18. Development of a Shortened Form of the Fennema-Sherman Mathematics Attitudes Scales.

    Mulhern, Fiona; Rae, Gordon


    Data from 196 Irish school children were analyzed and used to develop a shortened version of the Fennema-Sherman Mathematics Attitudes Scales (E. Fennema and J. Sherman, 1976). Internal consistency estimates of the reliability of scores on the whole scale and each of the subscales of the original and short form were favorable. (SLD)

  19. Differential Telomere Shortening in Blood versus Arteries in an Animal Model of Type 2 Diabetes

    Samira Tajbakhsh


    Full Text Available Vascular dysfunction is an early feature of diabetic vascular disease, due to increased oxidative stress and reduced nitric oxide (NO bioavailability. This can lead to endothelial cell senescence and clinical complications such as stroke. Cells can become senescent by shortened telomeres and oxidative stress is known to accelerate telomere attrition. Sirtuin 1 (SIRT1 has been linked to vascular health by upregulating endothelial nitric oxide synthase (eNOS, suppressing oxidative stress, and attenuating telomere shortening. Accelerated leukocyte telomere attrition appears to be a feature of clinical type 2 diabetes (T2D and therefore the telomere system may be a potential therapeutic target in preventing vascular complications of T2D. However the effect of T2D on vascular telomere length is currently unknown. We hypothesized that T2D gives rise to shortened leukocyte and vascular telomeres alongside reduced vascular SIRT1 expression and increased oxidative stress. Accelerated telomere attrition was observed in circulating leukocytes, but not arteries, in T2D compared to control rats. T2D rats had blunted arterial SIRT1 and eNOS protein expression levels which were associated with reduced antioxidant defense capacity. Our findings suggest that hyperglycemia and a deficit in vascular SIRT1 per se are not sufficient to prematurely shorten vascular telomeres.

  20. Bringing the School to the Children : Shortening the Path to EFA

    Lehman, Douglas


    Recent education planning initiatives in West and Central Africa show that the path to EFA may be shortened considerably by reconsidering the way basic education is delivered in isolated rural communities. Since independence, education systems have been expanding rapidly and are now serving most of the easy-to-reach population. For progress to continue, the focus must be shifted toward the...

  1. 76 FR 1504 - Pipeline Safety: Establishing Maximum Allowable Operating Pressure or Maximum Operating Pressure...


    ...: Establishing Maximum Allowable Operating Pressure or Maximum Operating Pressure Using Record Evidence, and... facilities of their responsibilities, under Federal integrity management (IM) regulations, to perform... system, especially when calculating Maximum Allowable Operating Pressure (MAOP) or Maximum Operating...

  2. Development and assessment of a shortened Quality of Life in Childhood Epilepsy Questionnaire (QOLCE-55).

    Goodwin, Shane W; Lambrinos, Anastasia I; Ferro, Mark A; Sabaz, Mark; Speechley, Kathy N


    To develop and validate a shortened version of the Quality of Life in Childhood Epilepsy Questionnaire (QOLCE). A secondary aim was to compare baseline risk factors predicting health-related quality of life (HRQoL) in children newly diagnosed with epilepsy, as identified using the original and shortened version. Data came from the Health-Related Quality of Life in Children with Epilepsy Study (HERQULES, N = 373), a multicenter prospective cohort study. Principal component analysis reduced the number of items from the original QOLCE, and factor analysis was used to assess the factor structure of the shortened version. Convergent and divergent validity was assessed by correlating the Child Health Questionnaire (CHQ) with the shortened QOLCE. Multiple regression identified risk factors at diagnosis for HRQoL at 24 months. A four-factor, higher-order, 55-item solution was obtained. A total of 21 items were removed. The final model represents functioning in four dimensions of HRQoL: Cognitive, Emotional, Social, and Physical. The shortened QOLCE demonstrated acceptable fit: Bentler's Comparative Fit Index = 0.944; Tucker-Lewis Index = 0.942; root mean square approximation = 0.058 (90% CI: 0.056-0.061); weighted root mean square residuals (WRMR) = 1.582, and excellent internal consistency (α = 0.96, subscales α > 0.80). Factor loadings were good (first-order: λ = 0.66-0.93; higher-order λ = 0.66-0.85; p < 0.001 for all). The shortened QOLCE scores correlated strongly with similar subscales of the Child Health Questionnaire (ρ = 0.38-0.70) while correlating weakly with dissimilar subscales (ρ = 0.30-0.31). While controlling for HRQoL at diagnosis, predictors for better HRQoL at 24 months were the following: no cognitive problems reported (p = 0.001), better family functioning (p = 0.014), fewer family demands (p = 0.008), with an interaction between baseline HRQoL and cognitive problems (p = 0.011). Results offer initial evidence regarding reliability and validity

  3. Minimal information in velocity space

    Evrard, Guillaume


    Jaynes' transformation group principle is used to derive the objective prior for the velocity of a non-zero rest-mass particle. In the case of classical mechanics, invariance under the classical law of addition of velocities, leads to an improper constant prior over the unbounded velocity space of classical mechanics. The application of the relativistic law of addition of velocities leads to a less simple prior. It can however be rewritten as a uniform volumetric distribution if the relativistic velocity space is given a non-trivial metric.

  4. Drug-induced QT-interval shortening following antiepileptic treatment with oral rufinamide.

    Schimpf, Rainer; Veltmann, Christian; Papavassiliu, Theano; Rudic, Boris; Göksu, Turgay; Kuschyk, Jürgen; Wolpert, Christian; Antzelevitch, Charles; Ebner, Alois; Borggrefe, Martin; Brandt, Christian


    The arrhythmogenic potential of short QT intervals has recently been highlighted in patients with a short QT syndrome. Drug-induced QT-interval prolongation is a known risk factor for ventricular tachyarrhythmias. However, reports on drug-induced QT-interval shortening are rare and proarrhythmic effects remain unclear. Recently, rufinamide, a new antiepileptic drug for the add-on treatment of Lennox-Gastaut syndrome, was approved in the European Union and the United States. Initial trials showed drug-induced QT-interval shortening. The aim of our study was to evaluate the effects of rufinamide on QT intervals in patients with difficult-to-treat epilepsies. Nineteen consecutive patients with Lennox-Gastaut syndrome and other epilepsy syndromes were included (n = 12 men; mean age 41 ± 12 years). QRS, QT, and T(peak)-T(end) intervals were analyzed before and during rufinamide treatment. The mean QT interval shortened significantly following rufinamide administration (QT interval 349 ± 23 ms vs 327 ± 17 ms; corrected QT interval 402 ± 22 ms vs 382 ± 16 ms; P = .002). T(peak)-T(end) intervals were 79 ± 17 ms before and 70 ± 20 ms on treatment (P = .07). The mean reduction of the corrected QT interval was 20 ± 18 ms. During follow-up (3.04 ± 1.09 years), no adverse events including symptomatic cardiac arrhythmias or sudden cardiac deaths were observed. QTc-interval shortening following oral rufinamide administration in a small patient group was not associated with significant clinical adverse effects. These observations notwithstanding, the ability of rufinamide to significantly shorten the QT interval portends a potential arrhythmogenic risk that may best be guarded against by periodic electrocardiographic recordings. Copyright © 2012 Heart Rhythm Society. Published by Elsevier Inc. All rights reserved.

  5. Oxidative Stress-induced Telomere Length Shortening of Circulating Leukocyte in Patients with Obstructive Sleep Apnea

    Kim, Kyung Soo; Kwak, Jin Wook; Lim, Su Jin; Park, Yong Kyun; Yang, Hoon Shik; Kim, Hyun Jik


    The main mechanism of pathogenesis which causes systemic complications in obstructive sleep apnea (OSA) patients is believed to be intermittent hypoxia-induced intermediary effect and it depends on the burden of oxidative stress during sleep. We aimed to search the predictive markers which reflect the burden of systemic oxidative stress in patients with OSA and whether excessive telomere length shortening is a characteristic feature that can assess oxidative stress levels. We used quantitative PCR to measure telomere length using peripheral blood genomic DNA. Telomere lengths were compared in an age- and body mass index (BMI)-dependent manner in 34 healthy volunteers and 43 OSA subjects. We also performed reactive oxygen species assay to measure the concentration of hydrogen peroxide in the peripheral blood of healthy volunteers and OSA subjects. We found that the serum concentration of hydrogen peroxide was considerably higher in OSA patients, and that this was closely related with the severity of OSA. Significantly shortened telomere length was observed in the circulating leukocytes of the peripheral blood of OSA patients, and telomere length shortening was aggravated more acutely in an age- and BMI-dependent manner. An inverse correlation was observed between the concentration of hydrogen peroxide and the telomere length of OSA patients and excessive telomere length shortening was also linked to severity of OSA. The results provided evidence that telomere length shortening or excessive cellular aging might be distinctive in circulating leukocyte of OSA patients and may be an predictive biomarker for reflect the burden of oxidative stress in the peripheral blood of OSA patients. PMID:27699083

  6. Two-Stage Surgical Treatment for Non-Union of a Shortened Osteoporotic Femur

    Galal Zaki Said


    Full Text Available Introduction: We report a case of non-union with severe shortening of the femur following diaphysectomy for chronic osteomyelitis.Case Presentation: A boy, aged 16 years presented with a dangling and excessively short left lower limb. He was using an elbow crutch in his right hand to help him walk. He had a history of diaphysectomy for chronic osteomyelitis at the age of 9. Examination revealed a freely mobile non-union of the left femur. The femur was the seat of an 18 cm shortening and a 4 cm defect at the non-union site; the knee joint was ankylosed in extension. The tibia and fibula were 10 cm short. Considering the extensive shortening in the femur and tibia in addition to osteoporosis, he was treated in two stages. In stage I, the femoral non-union was treated by open reduction, internal fixation and iliac bone grafting. The patient was then allowed to walk with full weight bearing in an extension brace for 7 months. In Stage II, equalization of leg length discrepancy (LLD was achieved by simultaneous distraction of the femur and tibia by unilateral frames. At the 6 month follow- up, he was fully weight bearing without any walking aid, with a heel lift to compensate the 1.5 cm shortening. Three years later he reported that he was satisfied with the result of treatment and was leading a normal life as a university student.Conclusions: Two-stage treatment succeeded to restore about 20 cm of the femoral shortening in a severely osteoporotic bone. It has also succeeded in reducing the treatment time of the external fixator.

  7. Residual force depression following muscle shortening is exaggerated by prior eccentric drop jump exercise.

    Dargeviciute, Gintare; Masiulis, Nerijus; Kamandulis, Sigitas; Skurvydas, Albertas; Westerblad, Håkan


    We studied the relation between two common force modifications in skeletal muscle: the prolonged force depression induced by unaccustomed eccentric contractions, and the residual force depression (rFD) observed immediately after active shortening. We hypothesized that rFD originates from distortion within the sarcomeres and the extent of rFD: 1) correlates to the force and work performed during the shortening steps, which depend on sarcomeric integrity; and 2) is increased by sarcomeric disorganization induced by eccentric contractions. Nine healthy untrained men (mean age 26 yr) participated in the study. rFD was studied in electrically stimulated knee extensor muscles. rFD was defined as the reduction in isometric torque after active shortening compared with the torque in a purely isometric contraction. Eccentric contractions were performed as 50 repeated drop jumps with active deceleration to 90° knee angle, immediately followed by a maximal upward jump. rFD was assessed before and 5 min to 72 h after drop jumps. The series of drop jumps caused a prolonged force depression, which was about two times larger at 20-Hz than at 50-Hz stimulation. There was a significant correlation between increasing rFD and increasing mechanical work performed during active shortening both before and after drop jumps. In addition, a given rFD was obtained at a markedly lower mechanical work after drop jumps. In conclusion, the extent of rFD correlates to the mechanical work performed during active shortening. A series of eccentric contractions causes a prolonged reduction of isometric force. In addition, eccentric contractions exaggerate rFD, which further decreases muscle performance during dynamic contractions.

  8. Force depression and relaxation kinetics after active shortening and deactivation in mouse soleus muscle.

    Van Noten, P; Van Leemputte, M


    After active shortening, isometric force production capacity of muscle is reduced (force depression, FD). The mechanism is incompletely understood but increasing cross-bridge detachment and/or decreasing attachment rate might be involved. Therefore we aimed to investigate the relation between work delivered during shortening (W), and change in half-relaxation time (Δ0.5RT) and change in the slow phase of muscle relaxation (Δkslow), considered as a marker for cross-bridge detachment rate, after shortening and after a short (0.7s) interruption of activation (deactivation). We hypothesized that shortening induces an accelerated relaxation related to W which is, similar to FD, largely abolished by a short deactivation. In 10 incubated supra-maximally stimulated mouse soleus muscles, we varied the amount of FD at L0 by varying shortening amplitude (0.6, 1.2 and 2.4mm). We found that W not only induces FD (R(2)=0.92) but also a dose dependent accelerated relaxation (R(2)=0.88 and R(2)=0.77 for respectively Δkslow and Δ0.5RT). In cyclic movements this is of functional significance, because the loss in force generating capacity might be (partially) compensated by faster relaxation. After a short deactivation, both FD and Δkslow were largely abolished but Δ0.5RT remained largely present. Under the assumption that Δkslow reflects a change in cross-bridge detachment rate, these results support the idea that FD is an intrinsic sarcomeric property originating from a work induced reduction of the number of force generating cross-bridges, however not via decreased attachment but via increased detachment rate. Copyright © 2013. Published by Elsevier Ltd.

  9. The Sherpa Maximum Likelihood Estimator

    Nguyen, D.; Doe, S.; Evans, I.; Hain, R.; Primini, F.


    A primary goal for the second release of the Chandra Source Catalog (CSC) is to include X-ray sources with as few as 5 photon counts detected in stacked observations of the same field, while maintaining acceptable detection efficiency and false source rates. Aggressive source detection methods will result in detection of many false positive source candidates. Candidate detections will then be sent to a new tool, the Maximum Likelihood Estimator (MLE), to evaluate the likelihood that a detection is a real source. MLE uses the Sherpa modeling and fitting engine to fit a model of a background and source to multiple overlapping candidate source regions. A background model is calculated by simultaneously fitting the observed photon flux in multiple background regions. This model is used to determine the quality of the fit statistic for a background-only hypothesis in the potential source region. The statistic for a background-plus-source hypothesis is calculated by adding a Gaussian source model convolved with the appropriate Chandra point spread function (PSF) and simultaneously fitting the observed photon flux in each observation in the stack. Since a candidate source may be located anywhere in the field of view of each stacked observation, a different PSF must be used for each observation because of the strong spatial dependence of the Chandra PSF. The likelihood of a valid source being detected is a function of the two statistics (for background alone, and for background-plus-source). The MLE tool is an extensible Python module with potential for use by the general Chandra user.

  10. Vestige: Maximum likelihood phylogenetic footprinting

    Maxwell Peter


    Full Text Available Abstract Background Phylogenetic footprinting is the identification of functional regions of DNA by their evolutionary conservation. This is achieved by comparing orthologous regions from multiple species and identifying the DNA regions that have diverged less than neutral DNA. Vestige is a phylogenetic footprinting package built on the PyEvolve toolkit that uses probabilistic molecular evolutionary modelling to represent aspects of sequence evolution, including the conventional divergence measure employed by other footprinting approaches. In addition to measuring the divergence, Vestige allows the expansion of the definition of a phylogenetic footprint to include variation in the distribution of any molecular evolutionary processes. This is achieved by displaying the distribution of model parameters that represent partitions of molecular evolutionary substitutions. Examination of the spatial incidence of these effects across regions of the genome can identify DNA segments that differ in the nature of the evolutionary process. Results Vestige was applied to a reference dataset of the SCL locus from four species and provided clear identification of the known conserved regions in this dataset. To demonstrate the flexibility to use diverse models of molecular evolution and dissect the nature of the evolutionary process Vestige was used to footprint the Ka/Ks ratio in primate BRCA1 with a codon model of evolution. Two regions of putative adaptive evolution were identified illustrating the ability of Vestige to represent the spatial distribution of distinct molecular evolutionary processes. Conclusion Vestige provides a flexible, open platform for phylogenetic footprinting. Underpinned by the PyEvolve toolkit, Vestige provides a framework for visualising the signatures of evolutionary processes across the genome of numerous organisms simultaneously. By exploiting the maximum-likelihood statistical framework, the complex interplay between mutational

  11. Consideration of wear rates at high velocity

    Hale, Chad S.

    The development of the research presented here is one in which high velocity relative sliding motion between two bodies in contact has been considered. Overall, the wear environment is truly three-dimensional. The attempt to characterize three-dimensional wear was not economically feasible because it must be analyzed at the micro-mechanical level to get results. Thus, an engineering approximation was carried out. This approximation was based on a metallographic study identifying the need to include viscoplasticity constitutive material models, coefficient of friction, relationships between the normal load and velocity, and the need to understand wave propagation. A sled test run at the Holloman High Speed Test Track (HHSTT) was considered for the determination of high velocity wear rates. In order to adequately characterize high velocity wear, it was necessary to formulate a numerical model that contained all of the physical events present. The experimental results of a VascoMax 300 maraging steel slipper sliding on an AISI 1080 steel rail during a January 2008 sled test mission were analyzed. During this rocket sled test, the slipper traveled 5,816 meters in 8.14 seconds and reached a maximum velocity of 1,530 m/s. This type of environment was never considered previously in terms of wear evaluation. Each of the features of the metallography were obtained through micro-mechanical experimental techniques. The byproduct of this analysis is that it is now possible to formulate a model that contains viscoplasticity, asperity collisions, temperature and frictional features. Based on the observations of the metallographic analysis, these necessary features have been included in the numerical model, which makes use of a time-dynamic program which follows the movement of a slipper during its experimental test run. The resulting velocity and pressure functions of time have been implemented in the explicit finite element code, ABAQUS. Two-dimensional, plane strain models

  12. Visual control of walking velocity.

    François, Matthieu; Morice, Antoine H P; Bootsma, Reinoud J; Montagne, Gilles


    Even if optical correlates of self-motion velocity have already been identified, their contribution to the control of displacement velocity remains to be established. In this study, we used a virtual reality set-up coupled to a treadmill to test the role of both Global Optic Flow Rate (GOFR) and Edge Rate (ER) in the regulation of walking velocity. Participants were required to walk at a constant velocity, corresponding to their preferred walking velocity, while eye height and texture density were manipulated. This manipulation perturbed the natural relationship between the actual walking velocity and its optical specification by GOFR and ER, respectively. Results revealed that both these sources of information are indeed used by participants to control walking speed, as demonstrated by a slowing down of actual walking velocity when the optical specification of velocity by either GOFR or ER gives rise to an overestimation of actual velocity, and vice versa. Gait analyses showed that these walking velocity adjustments result from simultaneous adaptations in both step length and step duration. The role of visual information in the control of self-motion velocity is discussed in relation with other factors.

  13. The effectiveness of stretch-shortening cycling in upper-limb extensor muscles during elite cross-country skiing with the double-poling technique.

    Zoppirolli, Chiara; Holmberg, Hans-Christer; Pellegrini, Barbara; Quaglia, Diego; Bortolan, Lorenzo; Schena, Federico


    This investigation was designed to evaluate the effectiveness of stretch-shortening cycling (SSC(EFF)) in upper-limb extensor muscles while cross-country skiing using the double-poling technique (DP). To this end, SSC(EFF) was analyzed in relation to DP velocity and performance. Eleven elite cross-country skiers performed an incremental test to determine maximal DP velocity (V(max)). Thereafter, cycle characteristics, elbow joint kinematics and poling forces were monitored on a treadmill while skiing at two sub-maximal and racing velocity (85% of V(max)). The average EMG activities of the triceps brachii and latissimus dorsi muscles were determined during the flexion and extension sub-phases of the poling cycle (EMG(FLEX), EMG(EXT)), as well as prior to pole plant (EMG(PRE)). SSC(EFF) was defined as the ratio of aEMG(FLEX) to aEMG(EXT). EMG(PRE) and EMG(FLEX) increased with velocity for both muscles (P < 0.01), as did SSC(EFF) (from 0.9 ± 0.3 to 1.3 ± 0.5 for the triceps brachii and from 0.9 ± 0.4 to 1.5 ± 0.5 for the latissimus dorsi) and poling force (from 253 ± 33 to 290 ± 36N; P < 0.05). Furthermore, SSC(EFF) was positively correlated to Vmax, to EMG(PRE) and EMG(FLEX) (P < 0.05). The neuromuscular adaptations made at higher velocities, when more poling force must be applied to the ground, exert a major influence on the DP performance of elite cross-country skiers.

  14. Development of an optimal velocity selection method with velocity obstacle

    Kim, Min Geuk; Oh, Jun Ho [KAIST, Daejeon (Korea, Republic of)


    The Velocity obstacle (VO) method is one of the most well-known methods for local path planning, allowing consideration of dynamic obstacles and unexpected obstacles. Typical VO methods separate a velocity map into a collision area and a collision-free area. A robot can avoid collisions by selecting its velocity from within the collision-free area. However, if there are numerous obstacles near a robot, the robot will have very few velocity candidates. In this paper, a method for choosing optimal velocity components using the concept of pass-time and vertical clearance is proposed for the efficient movement of a robot. The pass-time is the time required for a robot to pass by an obstacle. By generating a latticized available velocity map for a robot, each velocity component can be evaluated using a cost function that considers the pass-time and other aspects. From the output of the cost function, even a velocity component that will cause a collision in the future can be chosen as a final velocity if the pass-time is sufficiently long enough.

  15. Long-Term Outcome of Step-Cut Ulnar Shortening Osteotomy for Ulnar Impaction Syndrome.

    Papatheodorou, Loukia K; Baratz, Mark E; Bougioukli, Sofia; Ruby, Tyler; Weiser, Robert W; Sotereanos, Dean G


    Extra-articular ulnar shortening osteotomy is a common procedure for the surgical treatment of ulnar impaction syndrome. Several techniques for this osteotomy have been developed to avoid the morbidity associated with a standard transverse osteotomy. However, these techniques require special instrumentation and are expensive. The purpose of this study was to evaluate the outcome of step-cut ulnar shortening osteotomy without special jigs for ulnar impaction syndrome. A retrospective study of 164 consecutive patients who underwent step-cut ulnar shortening osteotomy between 2000 and 2010 was performed. The long arm of the step-cut osteotomy was oriented in the coronal plane parallel to the long axis of the ulna. The short arms of the osteotomy were perpendicular to the long axis in the axial plane. Fixation was performed with a palmar 3.5-mm standard neutralization plate and a lag screw. The goal of the osteotomy was to reduce ulnar variance, which was assessed in all patients with pronated grip-view radiographs preoperatively and postoperatively. Preoperative ulnar variance ranged from +1 to +6 mm. All patients were followed for at least 24 months. Union of the osteotomy site was achieved at a mean of 8.2 weeks. The union rate was 98.8%. There were 2 cases of nonunion, which required additional surgery. The mean postoperative ulnar variance was +0.2 mm (range, -1 to +1.5 mm) after a mean overall ulnar shortening of 2.5 mm. All patients returned to their previous work, in a mean of 4 months. The plate was removed from 12 patients because of plate-related symptoms. No other complications were encountered. The step-cut ulnar shortening osteotomy provides ample bone-to-bone contact and simplifies control of rotation. Stable internal fixation with standard techniques allowed an early return to functional activities. Palmar placement of the plate diminishes the need for plate removal. This is a simple and less expensive technique for ulnar shortening that does not

  16. Relationship between Spinal Cord Volume and Spinal Cord Injury due to Spinal Shortening.

    Feng Qiu

    Full Text Available Vertebral column resection is associated with a risk of spinal cord injury. In the present study, using a goat model, we aimed to investigate the relationship between changes in spinal cord volume and spinal cord injury due to spinal shortening, and to quantify the spinal cord volume per 1-mm height in order to clarify a safe limit for shortening. Vertebral column resection was performed at T10 in 10 goats. The spinal cord was shortened until the somatosensory-evoked potential was decreased by 50% from the baseline amplitude or delayed by 10% relative to the baseline peak latency. A wake-up test was performed, and the goats were observed for two days postoperatively. Magnetic resonance imaging was used to measure the spinal cord volume, T10 height, disc height, osteotomy segment height, and spinal segment height pre- and postoperatively. Two of the 10 goats were excluded, and hence, only data from eight goats were analyzed. The somatosensory-evoked potential of these eight goats demonstrated meaningful changes. With regard to neurologic function, five and three goats were classified as Tarlov grades 5 and 4 at two days postoperatively. The mean shortening distance was 23.6 ± 1.51 mm, which correlated with the d-value (post-pre of the spinal cord volume per 1-mm height of the osteotomy segment (r = 0.95, p < 0.001 and with the height of the T10 body (r = 0.79, p = 0.02. The mean d-value (post-pre of the spinal cord volume per 1-mm height of the osteotomy segment was 142.87 ± 0.59 mm3 (range, 142.19-143.67 mm3. The limit for shortening was approximately 106% of the vertebral height. The mean volumes of the osteotomy and spinal segments did not significantly change after surgery (t = 0.310, p = 0.765 and t = 1.241, p = 0.255, respectively. Thus, our results indicate that the safe limit for shortening can be calculated using the change in spinal cord volume per 1-mm height.

  17. Shortening in the Central Andes at the transition to flat slab subduction

    Safipour, R.; DeCelles, P. G.; Carrapa, B.; Kapp, P. A.; Gehrels, G. E.; Reiners, P. W.


    Shortening in the Central Andes is considered to decrease north and south of the apex of the Bolivian orocline, mainly owing to differences in the pre-existing stratigraphic architecture of the continental margin. Estimates of shortening in the central Andes of northern Argentina remain poorly documented, but are required for assessment of the regional kinematic history of the orogenic system. The problem is acute at the north to south transition from the high elevation Puna plateau to the lower elevation region of the Sierras Pampeanas intra-foreland block uplifts, which corresponds with a transition to a flat segment of the subducting Nazca plate. Although deformation in the Eastern Cordillera appears to have propagated forelandward from west to east, the trend in the Sierras Pampeanas is not clear from existing data. We mapped the structures along a roughly E-W transect at latitude 28°S in the Sierra de Las Planchadas of the northern Sierras Pampeanas to measure finite strain and kinematic indicators, and to develop a regional restorable cross section for measuring total shortening. We also sampled for low-T thermochronology in order to determine the timing of exhumation and inferred thrust propagation. A minimum of 40 km of shortening in the Sierra de Las Planchadas is estimated from our restored cross section. When added to the 20 km shortening documented in ranges to the east by previous studies, this brings the total minimum estimated shortening at this latitude to ~60 km. Apatite fission track ages from the hanging walls of thrusts are ~20 Ma, and apatite helium ages range from 10 Ma west of the range to 2.3 Ma in the Fiambalá basin which borders the range to the east. Cretaceous and Paleogene cooling ages are observed in ranges to the east of the Sierra de Las Planchadas, so the young cooling ages found in this study suggest that exhumation was complex and possibly diachronous at this latitude. To the extent that exhumation occurs simultaneously with

  18. Serotonin in the solitary tract nucleus shortens the laryngeal chemoreflex in anaesthetized neonatal rats.

    Donnelly, William T; Bartlett, Donald; Leiter, J C


    What is the central question of this study? Failure to terminate apnoea and arouse is likely to contribute to sudden infant death syndrome (SIDS). Serotonin is deficient in the brainstems of babies who died of SIDS. Therefore, we tested the hypothesis that serotonin in the nucleus of the solitary tract (NTS) would shorten reflex apnoea. What is the main finding and its importance? Serotonin microinjected into the NTS shortened the apnoea and respiratory inhibition associated with the laryngeal chemoreflex. Moreover, this effect was achieved through a 5-HT3 receptor. This is a new insight that is likely to be relevant to the pathogenesis of SIDS. The laryngeal chemoreflex (LCR), an airway-protective reflex that causes apnoea and bradycardia, has long been suspected as an initiating event in the sudden infant death syndrome. Serotonin (5-HT) and 5-HT receptors may be deficient in the brainstems of babies who die of sudden infant death syndrome, and 5-HT seems to be important in terminating apnoeas directly or in causing arousals or as part of the process of autoresuscitation. We hypothesized that 5-HT in the brainstem would limit the duration of the LCR. We studied anaesthetized rat pups between 7 and 21 days of age and made microinjections into the cisterna magna or into the nucleus of the solitary tract (NTS). Focal, bilateral microinjections of 5-HT into the caudal NTS significantly shortened the LCR. The 5-HT1a receptor antagonist, WAY 100635, did not affect the LCR consistently, nor did a 5-HT2 receptor antagonist, ketanserin, alter the duration of the LCR. The 5-HT3 specific agonist, 1-(3-chlorophenyl)-biguanide, microinjected bilaterally into the caudal NTS significantly shortened the LCR. Thus, endogenous 5-HT released within the NTS may curtail the respiratory depression that is part of the LCR, and serotonergic shortening of the LCR may be attributed to activation of 5-HT3 receptors within the NTS. 5-HT3 receptors are expressed presynaptically on C

  19. Velocity dependant splash behaviour

    Hamlett, C. A. E.; Shirtcliffe, N. J.; McHale, G.; Ahn, S.; Doerr, S. H.; Bryant, R.; Newton, M. I.


    Extreme soil water repellency can occur in nature via condensation of volatile organic compounds released during wildfires and can lead to increased erosion rate. Such extreme water repellent soil can be classified as superhydrophobic and shares similar chemical and topographical features to specifically designed superhydrophobic surfaces. Previous studies using high speed videography to investigate single droplet impact behaviour on artificial superhydrophobic have revealed three distinct modes of splash behaviour (rebound, pinned and fragmentation) which are dependent on the impact velocity of the droplet. In our studies, using high-speed videography, we show that such splash behaviour can be replicated on fixed 'model' water repellent soils (hydrophobic glass beads/particles). We show that the type of splash behaviour is dependent on both the size and chemical nature of the fixed particles. The particle shape also influences the splash behaviour as shown by drop impact experiments on fixed sand samples. We have also studied soil samples, as collected from the field, which shows that the type of droplet splash behaviour can lead to enhanced soil particle transport.

  20. Effects of increasing tip velocity on wind turbine rotor design.

    Resor, Brian Ray [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Maniaci, David Charles [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Berg, Jonathan Charles [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Richards, Phillip William [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)


    A reduction in cost of energy from wind is anticipated when maximum allowable tip velocity is allowed to increase. Rotor torque decreases as tip velocity increases and rotor size and power rating are held constant. Reduction in rotor torque yields a lighter weight gearbox, a decrease in the turbine cost, and an increase in the capacity for the turbine to deliver cost competitive electricity. The high speed rotor incurs costs attributable to rotor aero-acoustics and system loads. The increased loads of high speed rotors drive the sizing and cost of other components in the system. Rotor, drivetrain, and tower designs at 80 m/s maximum tip velocity and 100 m/s maximum tip velocity are created to quantify these effects. Component costs, annualized energy production, and cost of energy are computed for each design to quantify the change in overall cost of energy resulting from the increase in turbine tip velocity. High fidelity physics based models rather than cost and scaling models are used to perform the work. Results provide a quantitative assessment of anticipated costs and benefits for high speed rotors. Finally, important lessons regarding full system optimization of wind turbines are documented.

  1. Protein degradation and post-deboning tenderization in broiler breast meat with different degrees of muscle shortening

    Deboning broiler breast fillets prior to rigor mortis negatively influences tenderness due to sarcomere shortening. The effects of sarcomere shortening on muscle protein degradation and breast meat tenderization during post-deboning aging are not well understood. The objective of this study was to m...

  2. Examples of Vector Velocity Imaging

    Hansen, Peter M.; Pedersen, Mads M.; Hansen, Kristoffer L.


    To measure blood flow velocity in vessels with conventional ultrasound, the velocity is estimated along the direction of the emitted ultrasound wave. It is therefore impossible to obtain accurate information on blood flow velocity and direction, when the angle between blood flow and ultrasound wa...... with a 90° angle on the vessel. Moreover secondary flow in the abdominal aorta is illustrated by scanning on the transversal axis....

  3. Characterization of an ultrafast Bragg-Switch for shortening hard x-ray pulses

    Sander, M.; Koc, A.; Kwamen, C. T.; Michaels, H.; Reppert, A. v.; Pudell, J.; Zamponi, F.; Bargheer, M.; Sellmann, J.; Schwarzkopf, J.; Gaal, P.


    We present a nanostructured device that functions as photoacoustic hard x-ray switch. The device is triggered by femtosecond laser pulses and allows for temporal gating of hard x-rays on picosecond (ps) timescales. It may be used for pulse picking or even pulse shortening in 3rd generation synchrotron sources. Previous approaches mainly suffered from insufficient switching contrasts due to excitation-induced thermal distortions. We present a new approach where thermal distortions are spatially separated from the functional switching layers in the structure. Our measurements yield a switching contrast of 14, which is sufficient for efficient hard x-ray pulse shortening. The optimized structure also allows for utilizing the switch at high repetition rates of up to 208 kHz.


    Stanislav Kitarović


    Full Text Available This paper considers the hull girder ultimate strength of a bulk carrier at its midship section, as determined by an incremental-iterative progressive collapse analysis method prescribed by the International Association of Classification Societies Common Structural Rules for Bulk Carriers. In addition to the originally prescribed load – end shortening curves, curves determined by the nonlinear finite element method analysis (considering the influence of the idealized initial geometrical imperfections are also considered. Results obtained by both sets of curves are compared and discussed on both local (structural components load – end shortening curve and global (hull girder ulti-mate bending capacity and collapse sequence level, for both sagging and hogging cases.

  5. Reconstruction of neglected developmental dysplasia by total hip arthroplasty with subtrochanteric shortening osteotomy.

    Atilla, Bülent


    Patients with neglected developmental dysplasia (DDH) face with early osteoarthritis of the hip, limb length inequality and marked disability while total hip reconstruction is the only available choice.DDH has severe morphologic consequences, with distorted bony anatomy and soft tissue contractures around the hip. It is critical to evaluate patients thoroughly before surgery.Anatomic reconstruction at the level of true acetabulum with uncemented implant is the mainstay of treatment. This requires a subtrochanteric shortening osteotomy, which can be realised using different osteotomy and fixation options.Although a demanding technique with a high rate of related complications, once anatomic reconstruction of the hip is achieved, patients have a remarkably good functional capacity and implant survival during long follow-up periods. Cite this article: Atilla B. Reconstruction of neglected developmental dysplasia by total hip arthroplasty with subtrochanteric shortening osteotomy. EFORT Open Rev 2016;1:65-71. DOI: 10.1302/2058-5241.1.000026.

  6. Telomere shortening leads to earlier age of onset in ALS mice

    Linkus, Birgit; Wiesner, Diana; MeΔner, Martina; Karabatsiakis, Alexander; Scheffold, Annika; Rudolph, K. Lenhard; Thal, Dietmar R.; Weishaupt, Jochen H.; Ludolph, Albert C.; Danzer, Karin M.


    Telomere shortening has been linked to a variety of neurodegenerative diseases. Recent evidence suggests that reduced telomerase expression results in shorter telomeres in leukocytes from sporadic patients with amyotrophic lateral sclerosis (ALS) compared with healthy controls. Here, we have characterized telomere length in microglia, astroglia and neurons in human post mortem brain tissue from ALS patients and healthy controls. Moreover, we studied the consequences of telomerase deletion in a genetic mouse model for ALS. We found a trend towards longer telomeres in microglia in the brains of ALS patients compared to non-neurologic controls. Knockout of telomerase leading to telomere shortening accelerated the ALS phenotype in SOD1G93A–transgenic mice. Our results suggest that telomerase dysfunction might contribute to the age-related risk for ALS. PMID:26978042

  7. Surveying of the deformed terraces and crust shortening rate in the northwestern Tarim Basin: Comment


    @@ The paper of Shen et al., entitled "Surveying of the deformed terraces and crust shortening rate in the northwest Tarim Basin", was published in Chinese Science Bulletin (Vol. 46, No. 12)[1]. Shen et al. found the deformation of Late Pleistocene to Holocene terraces of the Boguzi River across the Artushi Anticline in the northwest Tarim Basin close to the Pamir, and made level survey and differential GPS measurement, which is of great importance to geodynamics for research on the coupling of Tianshan Mountains uplifting and Tarim Basin depression. But their understanding to the deformation mechanics of terraces and the calculation methods of crustal shortening are open to discussion. Therefore, we discuss it with Shen Jun et al.

  8. A neural circuit for angular velocity computation

    Samuel B Snider


    Full Text Available In one of the most remarkable feats of motor control in the animal world, some Diptera, such as the housefly, can accurately execute corrective flight maneuvers in tens of milliseconds. These reflexive movements are achieved by the halteres, gyroscopic force sensors, in conjunction with rapidly-tunable wing-steering muscles. Specifically, the mechanosensory campaniform sensilla located at the base of the halteres transduce and transform rotation-induced gyroscopic forces into information about the angular velocity of the fly's body. But how exactly does the fly's neural architecture generate the angular velocity from the lateral strain forces on the left and right halteres? To explore potential algorithms, we built a neuro-mechanical model of the rotation detection circuit. We propose a neurobiologically plausible method by which the fly could accurately separate and measure the three-dimensional components of an imposed angular velocity. Our model assumes a single sign-inverting synapse and formally resembles some models of directional selectivity by the retina. Using multidimensional error analysis, we demonstrate the robustness of our model under a variety of input conditions. Our analysis reveals the maximum information available to the fly given its physical architecture and the mathematics governing the rotation-induced forces at the haltere's end knob.

  9. Normalized velocity profiles of field-measured turbidity currents

    Xu, Jingping


    Multiple turbidity currents were recorded in two submarine canyons with maximum speed as high as 280 cm/s. For each individual turbidity current measured at a fixed station, its depth-averaged velocity typically decreased over time while its thickness increased. Some turbidity currents gained in speed as they traveled downcanyon, suggesting a possible self-accelerating process. The measured velocity profiles, first in this high resolution, allowed normalizations with various schemes. Empirical functions, obtained from laboratory experiments whose spatial and time scales are two to three orders of magnitude smaller, were found to represent the field data fairly well. The best similarity collapse of the velocity profiles was achieved when the streamwise velocity and the elevation were normalized respectively by the depth-averaged velocity and the turbidity current thickness. This normalization scheme can be generalized to an empirical function Y = exp(–αXβ) for the jet region above the velocity maximum. Confirming theoretical arguments and laboratory results of other studies, the field turbidity currents are Froude-supercritical.

  10. Foreland shortening and crustal balancing in the Andes at 30°S latitude

    Allmendinger, R. W.; Figueroa, D.; Synder, D.; Beer, J.; Mpodozis, C.; Isaacks, B. L.


    Excellent surface exposures, known Benioff zone geometry, a dynamic morphology, and the availability of industry seismic reflection data all make the Andes at 30°S an excellent transect for investigating crustal-scale balanced sections. 150-170 km of horizontal shortening has occurred in three major belts located between the trench and the foreland. The thin-skinned, east-verging Precordillera of western Argentina accounts for 60-75% of the total shortening and formed mostly since major volcanism ceased at ˜10 Ma. Industry seismic reflection data show that the décollement of the Precordillera belt is located anomalously deep at ˜15 km. The belt is dominated by fault propagation folds and contains several prominent out-of-sequence thrust faults. Seismic stratigraphie analysis shows that Miocene strata in the Iglesia Valley, located between the Precordillera and the crest of the Andes, accumulated in a piggy-back basin. Onlap relations on the western side indicate that the High Cordillera was uplifted as a major fault bend fold over a buried ramp. Thrusting in the two western belts, both in the High Cordillera of Chile, formed during the waning stages of arc volcanism, 11-16 Ma. and account for 25-40% of the shortening. The observed shortening is probably greater than can be accounted for with reasonable crustal thicknesses, indicating the possibility of continental truncation or erosion along the plate margin or an anomalously thick root held down by the nearly flat subducted Nazca Plate. Our preferred crustal geometry puts the ramp between upper and lower crustal deformation west of the high topography, requiring crustal scale tectonic wedging to thicken the crust beneath the crest of the Andes. This non-unique model provides a simple explanation of the first order morphology of the Andes at this latitude.

  11. [STT-arthrodesis versus radial shortening osteotomy for Kienböck's disease].

    Das Gupta, K; Tünnerhoff, H G; Haussmann, P


    Thirteen patients treated by STT fusion for Kienböck's disease (five stage 3 a, seven stage 3 b, and one stage 4) and 36 patients treated by radial shortening osteotomy (20 stage 3 a, 16 stage 3 b) were checked after 26 and 83 months average. The active range of motion and grip strength were compared by means of the Cooney score, discomfort and pain by the DASH score. X-rays were compared for the bone structure of the lunate and development or progress of carpal collapse. After STT fusion the active over-all range of motion decreased by about 10 degrees, grip strength improved slightly by approximately 10 %, pain and discomfort improved well. Consolidation of the lunate was seen in ten of thirteen patients. The patients treated with radial shortening osteotomy could all improve their range of motion by about 10 degrees and the grip strength by about 20 %, whereas discomfort and pain persisted in some cases. X-rays showed consolidation of the lunate in cases of eleven patients stage 3 a and twelve patients stage 3 b. Radiological results were not always corresponding to the clinical results and the patients' subjective estimation. A group of eight patients could be followed up after more than ten years; all of them showed excellent results. This may indicate the long-term result for those patients who benefit from radius shortening with early pain relief. We recommend both procedures for stage 3 a and 3 b and suggest to decide from case to case, according to the needs of the patient. Ulna minus variance or the patient's wish to restore full active range of motion indicate radial shortening.

  12. Variables Prognostic for Delayed Union and Nonunion Following Ulnar Shortening Fixed With a Dedicated Osteotomy Plate.

    Gaspar, Michael P; Kane, Patrick M; Zohn, Ralph C; Buckley, Taylor; Jacoby, Sidney M; Shin, Eon K


    To examine potential risk factors for the development of delayed or nonunion following elective ulnar shortening osteotomy using a dedicated osteotomy plating system. We performed a retrospective review of all patients who underwent elective ulnar shortening using the TriMed single osteotomy dynamic compression plating system by 1 of 2 fellowship-trained hand surgeons over a 5-year period. Demographic data and medical, surgical, and social histories were reviewed. Time to bony union was determined radiographically by a blinded reviewer. Bivariate statistical analysis was performed to examine the effect of explanatory variables on the time to union and the incidence of delayed or nonunion. Those variables associated with the development of delayed or nonunion were used in a multivariate logistic regression model. Complications, including the need for additional surgery, were also recorded. Seventy-two ulnar shortening osteotomy procedures were performed in 69 patients. Delayed union, defined as ≥ 6 months to union, occurred in 8 of 72 cases (11%). Of 72 surgeries, 4 (6%) resulted in nonunions, all of which required additional surgery. Hardware removal was performed in 13 of 72 (18%) of the cases. Time to union was significantly increased in smokers (6 ± 3 months) versus nonsmokers (3 ± 1 months). On multivariable analysis, diabetics and active smokers demonstrated a significantly higher risk of developing delayed union or nonunion. Patient age, sex, body mass index, thyroid disease, worker's compensation status, alcohol use, and amount smoked daily did not have an effect on the time to union or the incidence of delayed or nonunion. Despite the use of an osteotomy-specific plating system, smokers and diabetics were at significantly higher risk for both delayed union and nonunion following elective ulnar shortening osteotomy. Other known risk factors for suboptimal bony healing were not found to have a deleterious effect. Copyright © 2016 American Society for

  13. Shortened Length of Stay Improves Financial Outcomes in Living Donor Kidney Transplantation

    Villa, Manuel; Siskind, Eric; Sameyah, Emil; Alex, Asha; Blum, Mark; Tyrell, Richard; Fana, Melissa; Mishler, Marni; Godwin, Andrew; Kuncewitch, Michael; Alexander, Mohini; Israel, Ezra; Bhaskaran, Madhu; Calderon, Kellie; Jhaveri, Kenar D.; Sachdeva, Mala; Bellucci, Alessandro; Mattana, Joseph; Fishbane, Steven; Coppa, Gene; Molmenti, Ernesto


    Kidney transplantation is the preferred clinical and most cost-effective option for end-stage renal disease. Significant advances have taken place in the care of the transplant patients with improvements in clinical outcomes. The optimization of the costs of transplantation has been a constant goal as well. We present herein the impact in financial outcomes of a shortened length of stay after kidney transplant. PMID:24436592

  14. Disappearance of spasticity after selective dorsal rhizotomy does not prevent muscle shortening in children with cerebral palsy: a case report.

    Spijker, Margje; Strijers, Rob L M; van Ouwerkerk, Willem J R; Becher, Jules G


    Selective dorsal rhizotomy is an effective treatment for spasticity in children with cerebral palsy who have a spastic motor disorder. It is hypothesized that muscle shortening is related to spasticity; the lack of stretch of a muscle is thought to be the cause of muscle shortening. If this is true, the treatment for spasticity should prevent the occurrence of muscle shortening during growth. We present the case of 1 child with cerebral palsy and spastic diplegia, for whom the treatment with selective dorsal rhizotomy was successful in improving the walking abilities. She did, however, develop muscle shortening during growth. In conclusion, the development of muscle shortening during growth in children with cerebral palsy and spastic paresis cannot be prevented by treatment for the spasticity alone.

  15. Extreme femoral shortening: an approach to the chronically dislocated hip in the nonambulatory pediatric population.

    Kalawadia, Jay V; Patel, Ronak M; Jensen, Layne; Sarwark, John


    There are many surgical techniques for treating the chronically dislocated, painful hip in patients with neuromuscular spasticity, but each has significant complication rates. We conducted a study to examine the outcomes of a novel technique, an extreme varus femoral shortening osteotomy, used in nonambulatory patients with neuromuscular spasticity. Patients who underwent the procedure were identified retrospectively by surgical codes. Medical records were reviewed for range of motion, pain and functional assessment, surgical indications, complications, and results. In addition, preoperative and postoperative radiographs were assessed, and caretaker questionnaires reviewed. Between 2001 and 2010, 1 surgeon performed 6 femoral shortening osteotomies in 5 nonambulatory patients with neuromuscular spasticity. In all 5 cases, there were improvements in pain, sitting tolerance, ease of hygiene, and ease of transfers at a minimum follow-up of 2 years (mean, 3.4 years). Postoperative complications included asymptomatic heterotopic ossification and recurrent subluxation. Extreme femoral shortening is a reproducible surgical technique that alleviates pain and makes hygiene easier in nonambulatory children with symptomatic hip dislocations caused by neuromuscular spasticity. Our complication rate was comparable to that of other procedures.

  16. Field Monitoring of Column Shortenings in a High-Rise Building during Construction

    Hyo Seon Park


    Full Text Available The automatic monitoring of shortenings of vertical members in high-rise buildings under construction is a challenging issue in the high-rise building construction field. In this study, a practical system for monitoring column shortening in a high-rise building under construction is presented. The proposed monitoring system comprises the following components: (1 a wireless sensing system and (2 the corresponding monitoring software. The wireless sensing system comprises the sensors and energy-efficient wireless sensing units (sensor nodes, master nodes, and repeater nodes, which automate the processes for measuring the strains of vertical members and transmitting the measured data to the remote server. The monitoring software enables construction administrators to monitor real-time data collected by the server via an Internet connection. The proposed monitoring system is applied to actual 66-floor and 72-floor high-rise buildings under construction. The system enables automatic and real-time measurements of the shortening of vertical members, which can result in more precise construction.

  17. Circular and longitudinal muscles shortening indicates sliding patterns during peristalsis and transient lower esophageal sphincter relaxation.

    Patel, Nirali; Jiang, Yanfen; Mittal, Ravinder K; Kim, Tae Ho; Ledgerwood, Melissa; Bhargava, Valmik


    Esophageal axial shortening is caused by longitudinal muscle (LM) contraction, but circular muscle (CM) may also contribute to axial shortening because of its spiral morphology. The goal of our study was to show patterns of contraction of CM and LM layers during peristalsis and transient lower esophageal sphincter (LES) relaxation (TLESR). In rats, esophageal and LES morphology was assessed by histology and immunohistochemistry, and function with the use of piezo-electric crystals and manometry. Electrical stimulation of the vagus nerve was used to induce esophageal contractions. In 18 healthy subjects, manometry and high frequency intraluminal ultrasound imaging during swallow-induced esophageal contractions and TLESR were evaluated. CM and LM thicknesses were measured (40 swallows and 30 TLESRs) as markers of axial shortening, before and at peak contraction, as well as during TLESRs. Animal studies revealed muscular connections between the LM and CM layers of the LES but not in the esophagus. During vagal stimulated esophageal contraction there was relative movement between the LM and CM. Human studies show that LM-to-CM (LM/CM) thickness ratio at baseline was 1. At the peak of swallow-induced contraction LM/CM ratio decreased significantly (2). The pattern of contraction of CM and LM suggests sliding of the two muscles. Furthermore, the sliding patterns are in the opposite direction during peristalsis and TLESR.


    邢国刚; 樊小力; 吴苏娣; 宋新爱; 朱保恭; 唐斌


    Objective: To study the possible mechanism and prevention of disuse muscle atrophy. Methods: The shortened immobilization (plaster fixation) of rat' s soleus muscle (SOL) was used as the model of muscle and the lengthened immobilization of rat' s SOL muscle as "passive stretch" method. Types of skeletal muscle fibers were differentiated with m - ATPase staining technique. The changes of rat' s SOL muscle weight (wet weight) as well as the types and the mean cross - sectional area (CSA) of muscle fibers were examined respectively on day 2, 4,7, 14 and 21 under both shortened and lengthened immobilization and then the effect of passive stretch on soleus muscle atrophy in immobilized rats was observed. Results: When shortened immobilization was applied for 4 days, SOL muscle weight (wet weight) became lighter; the fiber crosssectional area (CSA) shrank and type Ⅰ muscle fibers started transforming into type Ⅱ, which all indicated immobilized muscles began to atrophy and as immobilization proceeded, muscle atrophy proceeded toward higher level. In contrast to that, when lengthened immobilization was applied, SOL muscle didn' t show any sign of atrophy until 7th day, and reached its highest level on day 14 and maintained that level even though immobilization continued. Conclusion: From the results, we conclude that passive stretch can either relieve or defer disuse muscle atrophy.

  19. Psychometric properties of a shortened version of the Physical Self-Concept Questionnaire (PSQ-S).

    Rodríguez-Fernández, Arantzazu; Axpe, Inge; Goñi, Alfredo


    The four-dimensional model of physical self-concept which differentiates the physical self-perceptions of ability, condition, attractiveness and strength is widely accepted. In the last two decades much research has been done on the physical self-concept and its relations with the psychological well-being/distress, anxiety disorders or Eating Behavior Disorders (EBD). To validate a shortened version of the Physical Self-Concept Questionnaire (PSQ-S) and verify its ability to discriminate between people with different levels of EBD. Responses of 1478 subjects between 13 and 21 years old to the shortened version of the PSQ were analyzed in order to check indexes of reliability and validity. Furthermore, the scores of 96 women aged 14 to 23 years old diagnosed of EBD were compared to 96 others without clinical diagnosis. The results indicate a reliability of 0.93 and confirm the tetrafactorial structure of the physical selfconcept. The highest physical self-concept is that of those without a clinical diagnosis of EBD. The Shortened-PSQ is a simple, reliable and suitable screening tool both for educational and clinical settings. It also provides a sufficient measure of physical self-concept for research purposes.

  20. Effective suppression of pulse shortening in a relativistic backward wave oscillator

    Cao, Yibing; Song, Zhimin; Wu, Ping; Fan, Zhiqiang; Zhang, Yuchuan; Teng, Yan; Sun, Jun


    This paper discusses pulse shortening present in a C-band relativistic backward wave oscillator (RBWO). Effects of the collector plasma are believed to be the main cause. This viewpoint is first verified in numerical simulation. The simulation results show that light charged particles such as hydrogen ions in the collector plasma would axially enter into the beam-microwave interaction region and suppress high-power microwave (HPM) generation. Simultaneously, heavy charged particles such as oxygen or ferric ions in the collector plasma would radially expand out and change the end reflection of the RBWO. All these effects can result in pulse shortening. Simulations also demonstrate that a coaxial collector can effectively suppress plasma effects by retarding their axial and radial expansions. Furthermore, a HPM experiment has confirmed the validity of the coaxial collector. Using this structure, the output power of the RBWO has been increased from 2.5 GW to 3 GW. No pulse shortening has been observed in the HPM experiment.

  1. Shortened Lifespan and Lethal Hemorrhage in a Hemophilia A Mouse Model.

    Janice M Staber

    Full Text Available Hemophilia A animal models have helped advance our understanding of factor VIII deficiency. Previously, factor VIII deficient mouse models were reported to have a normal life span without spontaneous bleeds. However, the bleeding frequency and survival in these animals has not been thoroughly evaluated.To investigate the survival and lethal bleeding frequency in two strains of E-16 hemophilia A mice.We prospectively studied factor VIII deficient hemizygous affected males (n = 83 and homozygous affected females (n = 55 for survival and bleeding frequency. Animals were evaluated for presence and location of bleeds as potential cause of death.Hemophilia A mice had a median survival of 254 days, which is significantly shortened compared to wild type controls (p < 0.0001. In addition, the hemophilia A mice experienced hemorrhage in several tissues. This previously-underappreciated shortened survival in the hemophilia A murine model provides new outcomes for investigation of therapeutics and also reflects the shortened lifespan of patients if left untreated.

  2. Decreasing initial telomere length in humans intergenerationally understates age-associated telomere shortening.

    Holohan, Brody; De Meyer, Tim; Batten, Kimberly; Mangino, Massimo; Hunt, Steven C; Bekaert, Sofie; De Buyzere, Marc L; Rietzschel, Ernst R; Spector, Tim D; Wright, Woodring E; Shay, Jerry W


    Telomere length shortens with aging, and short telomeres have been linked to a wide variety of pathologies. Previous studies suggested a discrepancy in age-associated telomere shortening rate estimated by cross-sectional studies versus the rate measured in longitudinal studies, indicating a potential bias in cross-sectional estimates. Intergenerational changes in initial telomere length, such as that predicted by the previously described effect of a father's age at birth of his offspring (FAB), could explain the discrepancy in shortening rate measurements. We evaluated whether changes occur in initial telomere length over multiple generations in three large datasets and identified paternal birth year (PBY) as a variable that reconciles the difference between longitudinal and cross-sectional measurements. We also clarify the association between FAB and offspring telomere length, demonstrating that this effect is substantially larger than reported in the past. These results indicate the presence of a downward secular trend in telomere length at birth over generational time with potential public health implications.

  3. Postsystolic Shortening Is Associated with Altered Right Ventricular Function in Children after Tetralogy of Fallot Surgical Repair


    The aim of the study was to determine whether segmental interactions, as expressed by postsystolic shortening (PSS), affects RV mechanics and are connected with impaired systolic and diastolic function in rTOF children. Patients and Methods: 55 rTOF adolescent (study group), and 34 healthy volunteers (control group) were examined using classical Doppler flow (Doppler), Tissue Doppler Imaging (TDI) and Speckle Tracking Echocardiography (STE). PSS was found to occur when time to peak (TTP) was longer than pulmonary valve closure time (PVCT). TTP and strain were derived from RV lateral segments—basal (BL), medial (ML) and apical (AL) in STE. PVCT was measured from the beginning of QRS complex in the ECG to the termination of Doppler flow at the pulmonary valve. TDI was obtained at the lateral tricuspid annulus site and the systolic (S′), early (E′) and late diastolic (A’) peak velocities were measured along with isovolumic contraction (IVCT), and relaxation (IVRT) time. PW was used to measure early tricuspid inflow velocity (E) for calculating the E/E’ ratio. The TDI data in patients with PSS presence (TTP>PVCT) and those in whom it did not occur (TTP≤PVCT) were compared. Results: PSS in BL, ML and AL were observed respectively in: 27(51,9%), 9 (18%), and 8 (16,7%) patients. Mean values of TTP in BL, ML, and AL were respectively: 420.6±55.5ms, 389.8±50.0ms and 366.7±59.0ms. PVCT mean value was 396.6±33.5ms. In the study group, the mean E’ in TTP>PVCT was significantly lower (4.8±1.8 cm/s) compared to mean E’ in TTP≤PVCT (8.4±2.6 cm/s), pPCVT than in TTP≤PVCT, respectively 21.6±7.3 vs 12.2±5.1, pPVCT compared to IVRT in TTP≤PVCT, respectively 95.9±38.7 vs 77.0±35.1, pPVCT, significantly higher strain in BL (-28.8±8.7%) was observed when compared to that parameter in TTP≤PVCT (-35.3±13.1%), p <0.05. Conclusions: Tissue Doppler Echocardiography and Speckle Tracking Echocardiography are useful techniques for detecting regional systolic

  4. Receiver function estimated by maximum entropy deconvolution

    吴庆举; 田小波; 张乃铃; 李卫平; 曾融生


    Maximum entropy deconvolution is presented to estimate receiver function, with the maximum entropy as the rule to determine auto-correlation and cross-correlation functions. The Toeplitz equation and Levinson algorithm are used to calculate the iterative formula of error-predicting filter, and receiver function is then estimated. During extrapolation, reflective coefficient is always less than 1, which keeps maximum entropy deconvolution stable. The maximum entropy of the data outside window increases the resolution of receiver function. Both synthetic and real seismograms show that maximum entropy deconvolution is an effective method to measure receiver function in time-domain.

  5. Sodium Velocity Maps on Mercury

    Potter, A. E.; Killen, R. M.


    The objective of the current work was to measure two-dimensional maps of sodium velocities on the Mercury surface and examine the maps for evidence of sources or sinks of sodium on the surface. The McMath-Pierce Solar Telescope and the Stellar Spectrograph were used to measure Mercury spectra that were sampled at 7 milliAngstrom intervals. Observations were made each day during the period October 5-9, 2010. The dawn terminator was in view during that time. The velocity shift of the centroid of the Mercury emission line was measured relative to the solar sodium Fraunhofer line corrected for radial velocity of the Earth. The difference between the observed and calculated velocity shift was taken to be the velocity vector of the sodium relative to Earth. For each position of the spectrograph slit, a line of velocities across the planet was measured. Then, the spectrograph slit was stepped over the surface of Mercury at 1 arc second intervals. The position of Mercury was stabilized by an adaptive optics system. The collection of lines were assembled into an images of surface reflection, sodium emission intensities, and Earthward velocities over the surface of Mercury. The velocity map shows patches of higher velocity in the southern hemisphere, suggesting the existence of sodium sources there. The peak earthward velocity occurs in the equatorial region, and extends to the terminator. Since this was a dawn terminator, this might be an indication of dawn evaporation of sodium. Leblanc et al. (2008) have published a velocity map that is similar.

  6. Maximum Power from a Solar Panel

    Michael Miller


    Full Text Available Solar energy has become a promising alternative to conventional fossil fuel sources. Solar panels are used to collect solar radiation and convert it into electricity. One of the techniques used to maximize the effectiveness of this energy alternative is to maximize the power output of the solar collector. In this project the maximum power is calculated by determining the voltage and the current of maximum power. These quantities are determined by finding the maximum value for the equation for power using differentiation. After the maximum values are found for each time of day, each individual quantity, voltage of maximum power, current of maximum power, and maximum power is plotted as a function of the time of day.

  7. Dyslipidemia and chronic inflammation markers are correlated with telomere length shortening in Cushing's syndrome.

    Anna Aulinas

    Full Text Available Cushing's syndrome (CS increases cardiovascular risk (CVR and adipocytokine imbalance, associated with an increased inflammatory state. Telomere length (TL shortening is a novel CVR marker, associated with inflammation biomarkers. We hypothesized that inflammatory state and higher CVR in CS might be related to TL shortening, as observed in premature aging.To evaluate relationships between TL, CVR and inflammation markers in CS.In a cross-sectional study, 77 patients with CS (14 males, 59 pituitary-, 17 adrenal- and 1 ectopic-origin; 21 active disease and 77 age-, gender-, smoking-matched controls were included. Total white blood cell TL was measured by TRF-Southern technique. Clinical data and blood samples were collected (lipids, adrenal function, glucose. Adiponectin, interleukin-6 (IL6 and C-reactive protein (CRP were available in a subgroup of patients (n=32. Correlations between TL and clinical features were examined and multiple linear regression analysis was performed to investigate potential predictors of TL.Dyslipidemic CS had shorter TL than non-dyslipidemic subjects (7328±1274 vs 7957±1137 bp, p<0.05. After adjustment for age and body mass index, cured and active CS dyslipidemic patients had shorter TL than non-dyslipidemic CS (cured: 7187±1309 vs 7868±1104; active: 7203±1262 vs 8615±1056, respectively, p<0.05. Total cholesterol and triglycerides negatively correlated with TL (r-0.279 and -0.259, respectively, p<0.05, as well as CRP and IL6 (r-0.412 and -0.441, respectively, p<0.05. No difference in TL according the presence of other individual CVR factors (hypertension, diabetes mellitus, obesity were observed in CS or in the control group. Additional TL shortening was observed in dyslipidemic obese patients who were also hypertensive, compared to those with two or less CVR factors (6956±1280 vs 7860±1180, respectively, p<0.001. Age and dyslipidemia were independent negative predictors of TL.TL is shortened in dyslipidemic CS

  8. The acceptable air velocity range for local air movement in the Tropics

    Gong, Nan; Tham, K.W.; Melikov, Arsen Krikor;


    and high velocity values. Most dissatisfaction with air movement is caused by thermal sensation, with air movement perception accounting for a smaller proportion. The subjects preferred air movement to be between "just right" and "slightly breezy" and preferred their thermal sensation to be between...... "neutral" and "slightly cool. The study also identified an acceptable air velocity range from 0.3 up to 0.9 m/s under the experimental conditions. This velocity range is relevant for the design of personalized ventilation in practice. This preferred velocity range is higher than the maximum velocity...

  9. Introduction to vector velocity imaging

    Jensen, Jørgen Arendt; Udesen, Jesper; Hansen, Kristoffer Lindskov;

    Current ultrasound scanners can only estimate the velocity along the ultrasound beam and this gives rise to the cos() factor on all velocity estimates. This is a major limitation as most vessels are close to perpendicular to the beam. Also the angle varies as a function of space and time making...

  10. Instantaneous Velocity Using Photogate Timers

    Wolbeck, John


    Photogate timers are commonly used in physics laboratories to determine the velocity of a passing object. In this application a card attached to a moving object breaks the beam of the photogate timer providing the time for the card to pass. The length L of the passing card can then be divided by this time to yield the average velocity (or speed)…

  11. Kriging Interpolating Cosmic Velocity Field

    Yu, Yu; Jing, Yipeng; Zhang, Pengjie


    [abridge] Volume-weighted statistics of large scale peculiar velocity is preferred by peculiar velocity cosmology, since it is free of uncertainties of galaxy density bias entangled in mass-weighted statistics. However, measuring the volume-weighted velocity statistics from galaxy (halo/simulation particle) velocity data is challenging. For the first time, we apply the Kriging interpolation to obtain the volume-weighted velocity field. Kriging is a minimum variance estimator. It predicts the most likely velocity for each place based on the velocity at other places. We test the performance of Kriging quantified by the E-mode velocity power spectrum from simulations. Dependences on the variogram prior used in Kriging, the number $n_k$ of the nearby particles to interpolate and the density $n_P$ of the observed sample are investigated. (1) We find that Kriging induces $1\\%$ and $3\\%$ systematics at $k\\sim 0.1h{\\rm Mpc}^{-1}$ when $n_P\\sim 6\\times 10^{-2} ({\\rm Mpc}/h)^{-3}$ and $n_P\\sim 6\\times 10^{-3} ({\\rm Mpc...

  12. The Relationship between Pedal Force and Crank Angular Velocity in Sprint Cycling.

    Bobbert, Maarten Frank; Casius, L J Richard; Van Soest, Arthur J


    Relationships between tangential pedal force and crank angular velocity in sprint cycling tend to be linear. We set out to understand why they are not hyperbolic, like the intrinsic force-velocity relationship of muscles. We simulated isokinetic sprint cycling at crank angular velocities ranging from 30 to 150 rpm with a forward dynamic model of the human musculoskeletal system actuated by eight lower extremity muscle groups. The input of the model was muscle stimulation over time, which we optimized to maximize average power output over a cycle. Peak tangential pedal force was found to drop more with crank angular velocity than expected based on intrinsic muscle properties. This linearizing effect was not due to segmental dynamics but rather due to active state dynamics. Maximizing average power in cycling requires muscles to bring their active state from as high as possible during shortening to as low as possible during lengthening. Reducing the active state is a relatively slow process, and hence must be initiated a certain amount of time before lengthening starts. As crank angular velocity goes up, this amount of time corresponds to a greater angular displacement, so the instant of switching off extensor muscle stimulation must occur earlier relative to the angle at which pedal force was extracted for the force-velocity relationship. Relationships between pedal force and crank angular velocity in sprint cycling do not reflect solely the intrinsic force-velocity relationship of muscles but also the consequences of activation dynamics.

  13. Diffraction imaging and velocity analysis using oriented velocity continuation

    Decker, Luke


    We perform seismic diffraction imaging and velocity analysis by separating diffractions from specular reflections and decomposing them into slope components. We image slope components using extrapolation in migration velocity in time-space-slope coordinates. The extrapolation is described by a convection-type partial differential equation and implemented efficiently in the Fourier domain. Synthetic and field data experiments show that the proposed algorithm is able to detect accurate time-migration velocities by automatically measuring the flatness of events in dip-angle gathers.

  14. Study on the Velocity of Partially Submerged Landslide

    Wang Yang


    Full Text Available Hydraulic resistance is one of the most important factors which affect the velocity of the partially submerged landslide when it moves into river at a high speed. In this paper, an experiment system was designed including a water tank, a moving frame fixed over the tank with liquid level sensors, blocks, and velocity control apparatus. Six blocks with different areas were used for experiments and each block moved at five different velocities in water tank. Test results showed that the increment of the pressure head was proportional to the square velocity of submerged block. Based on that, the total water pressure and corresponding hydraulic resistance of the moving block in water tank were obtained, and the latter was used to analyze hydraulic resistance acting on partially submerged landslide. Method of slice was applied to calculate the forces of landslide with curved slip surface. The dynamics and kinematics equation of landslide were used to calculate the velocity. Taking the Dayantang landslide as an example, velocities with different travel distance were obtained. The results showed that the maximum velocity of Dayantang landslide considering hydraulic resistance was 18.6% less than that without considering hydraulic resistance.

  15. Estimation of the Radial Distribution of the Tangential Velocity in a Vortex Chamber

    Akira OGAWA; Tsuyoshi IKARI; Hiroyuki MURAKAMI; Kouhei SATHO


    The estimation of maximum tangential velocity becomes a very important factor for the estimation of performances of the vortex chamber. In this paper, a proposed flow model of how to estimate the maximum tangential velocity in the special form of the vortex chamber is described in detail. The pressure drop basing upon the rapid expansion by flowing from the inlet pipe into the cyclone body is estimated as half of the dynamic pressure in the inlet pipe.

  16. A structural equation model to investigate the impact of missing occlusal units on objective masticatory function in patients with shortened dental arches.

    Fueki, K; Yoshida, E; Igarashi, Y


    The aim of this study was to investigate the impact of missing occlusal units (MOUs) on objective masticatory function with respect to food comminuting and mixing ability. Sixty partially dentate patients (mean age, 64·1 years) with shortened dental arches participated in the study. Food comminuting ability was assessed using a masticatory performance test with peanuts as a test food. Food mixing ability was assessed using a mixing ability test with a two-coloured wax cube. Maximum bite force (MBF) was measured using a pressure-sensitive film as a mediator for food comminuting and mixing ability. A structural equation model was constructed based on a hypothesis that MOUs would be associated with reduced MBF and impairment of food comminuting and mixing ability. Structural equation modelling analysis found significant direct effects of MOU on median particle size and mixing ability index (MAI) (P dental arches.

  17. Active myocyte shortening during the 'isovolumetric relaxation' phase of diastole is responsible for ventricular suction; 'systolic ventricular filling'.

    Buckberg, Gerald D; Castellá, Manuel; Gharib, Morteza; Saleh, Saleh


    To study the 'isovolumetric relaxation' phase of rapid ventricular filling by analysis of the shortening of cardiac muscle in the endocardial and epicardial segments of the left ventricle in the dual helical model of the ventricular band, described by Torrent-Guasp. In 10 pigs (27-82 kg), temporal shortening by sonomicrometer crystals was recorded while recording ECG, and measuring intraventricular pressure and dP/dt with Millar pressure transducers. The following sequence was observed; shortening began in descending or endocardial segment, and 82+/-23 ms later it was initiated in the epicardial or ascending segment of the band. The descending segment stops shortening during the rapid filling phase of fast descent of ventricular pressure, but the ascending segment shortening continues for 92+/-33 ms, so that active shortening continues during the period of isovolumetric relaxation. During the rapid filling phase, dopamine decreased the interval between completion of endocardial and termination of epicardial contraction from 92+/-20 to 33+/-8 ms. Conversely propranolol delayed the start of epicardial shortening from 82+/-23 to 121+/-20 ms, and prolonged the duration of endocardial contraction, causing a closer (21+/-5 ms vs 92+/-20 ms) interval between termination of contraction of endocardial and epicardial fibers. The resultant slope of the rapid descent of the left ventricular pressure curve became prolonged. These time sequences show that ongoing unopposed ascending segment shortening occurs during the phase of rapid fall of ventricular pressure. These active shortening phases respond to positive and negative inotropic stimulation, and indicate the classic concept of 'isovolumetric relaxation', IVR, must be reconsidered, and the new term 'isovolumetric contraction', IVC, or systolic ventricular filing may be used.

  18. The inverse maximum dynamic flow problem

    BAGHERIAN; Mehri


    We consider the inverse maximum dynamic flow (IMDF) problem.IMDF problem can be described as: how to change the capacity vector of a dynamic network as little as possible so that a given feasible dynamic flow becomes a maximum dynamic flow.After discussing some characteristics of this problem,it is converted to a constrained minimum dynamic cut problem.Then an efficient algorithm which uses two maximum dynamic flow algorithms is proposed to solve the problem.

  19. Inversion methods for fast-ion velocity-space tomography in fusion plasmas

    Jacobsen, Asger Schou; Stagner, L.; Salewski, Mirko


    Velocity-space tomography has been used to infer 2D fast-ion velocity distribution functions. Here we compare the performance of five different tomographic inversion methods: truncated singular value decomposition, maximum entropy, minimum Fisher information and zeroth and first-order Tikhonov re...

  20. Fetal atrioventricular and outflow tract flow velocity waveforms during conducted and blocked supraventricular extrasystoles

    K. van der Mooren (K.); J.W. Wladimiroff (Juriy); Th. Stijnen (Theo)


    textabstractMaximum flow velocity waveforms at atrioventricular and outflow tract level were studied cross‐sectionally in 19 human fetuses with conducted and/or blocked supraventricular extrasystoles ranging from 25 to 38 weeks of gestation. At outflow tract level, peak systolic velocity and acceler

  1. Maximum permissible voltage of YBCO coated conductors

    Wen, J.; Lin, B.; Sheng, J.; Xu, J.; Jin, Z. [Department of Electrical Engineering, Shanghai Jiao Tong University, Shanghai (China); Hong, Z., E-mail: [Department of Electrical Engineering, Shanghai Jiao Tong University, Shanghai (China); Wang, D.; Zhou, H.; Shen, X.; Shen, C. [Qingpu Power Supply Company, State Grid Shanghai Municipal Electric Power Company, Shanghai (China)


    Highlights: • We examine three kinds of tapes’ maximum permissible voltage. • We examine the relationship between quenching duration and maximum permissible voltage. • Continuous I{sub c} degradations under repetitive quenching where tapes reaching maximum permissible voltage. • The relationship between maximum permissible voltage and resistance, temperature. - Abstract: Superconducting fault current limiter (SFCL) could reduce short circuit currents in electrical power system. One of the most important thing in developing SFCL is to find out the maximum permissible voltage of each limiting element. The maximum permissible voltage is defined as the maximum voltage per unit length at which the YBCO coated conductors (CC) do not suffer from critical current (I{sub c}) degradation or burnout. In this research, the time of quenching process is changed and voltage is raised until the I{sub c} degradation or burnout happens. YBCO coated conductors test in the experiment are from American superconductor (AMSC) and Shanghai Jiao Tong University (SJTU). Along with the quenching duration increasing, the maximum permissible voltage of CC decreases. When quenching duration is 100 ms, the maximum permissible of SJTU CC, 12 mm AMSC CC and 4 mm AMSC CC are 0.72 V/cm, 0.52 V/cm and 1.2 V/cm respectively. Based on the results of samples, the whole length of CCs used in the design of a SFCL can be determined.

  2. Developmental remodeling and shortening of the cardiac outflow tract involves myocyte programmed cell death.

    Watanabe, M; Choudhry, A; Berlan, M; Singal, A; Siwik, E; Mohr, S; Fisher, S A


    The embryonic outflow tract is a simple tubular structure that connects the single primitive ventricle with the aortic sac and aortic arch arteries. This structure undergoes a complex sequence of morphogenetic processes to become the portion of the heart that aligns the right and left ventricles with the pulmonary artery and aorta. Abnormalities of the outflow tract are involved in many clinically significant congenital cardiac defects; however, the cellular and molecular processes governing the development of this important structure are incompletely understood. Histologic and tissue-tagging studies indicate that the outflow tract tissues compact and are incorporated predominantly into a region of the right ventricle. The hypothesis tested in the current study was that cell death or apoptosis in the muscular portion of the outflow tract is an important cellular mechanism for outflow tract shortening. The tubular outflow tract myocardium was specifically marked by infecting myocytes of the chicken embryo heart with a recombinant replication-defective adenovirus expressing beta-galactosidase (beta-gal) under the control of the cytomegalovirus promoter. Histochemical detection of the beta -gal-labeled outflow tract myocytes revealed that the tubular structure shortened to become a compact ring at the level of the pulmonic infundibulum over several days of development (stages 25-32, embryonic days 4-8). The appearance of apoptotic cardiomyocytes was correlated with OFT shortening by two histologic assays, TUNEL labeling of DNA fragments and AnnexinV binding. The rise and fall in the number of apoptotic myocytes detected by histologic analyses paralleled the change in activity levels of Caspase-3, a protease in the apoptotic cascade, measured in outflow tract homogenates. These results suggest that the elimination of myocytes by programmed cell death is one mechanism by which the outflow tract myocardium remodels to form the proper connection between the ventricular

  3. New insight into the shortening of the collagen fibril D-period in human cornea.

    Jastrzebska, Maria; Tarnawska, Dorota; Wrzalik, Roman; Chrobak, Artur; Grelowski, Michal; Wylegala, Edward; Zygadlo, Dorota; Ratuszna, Alicja


    Collagen fibrils type I display a typical banding pattern, so-called D-periodicity, of about 67 nm, when visualized by atomic force or electron microscopy imaging. Herein we report on a significant shortening of the D-period for human corneal collagen fibrils type I (21 ± 4 nm) upon air-drying, whereas no changes in the D-period were observed for human scleral collagen fibrils type I (64 ± 4 nm) measured under the same experimental conditions as the cornea. It was also found that for the corneal stroma fixed with glutaraldehyde and air-dried, the collagen fibrils show the commonly accepted D-period of 61 ± 8 nm. We used the atomic force microscopy method to image collagen fibrils type I present in the middle layers of human cornea and sclera. The water content in the cornea and sclera samples was varying in the range of .066-.085. Calculations of the D-period using the theoretical model of the fibril and the FFT approach allowed to reveal the possible molecular mechanism of the D-period shortening in the corneal collagen fibrils upon drying. It was found that both the decrease in the shift and the simultaneous reduction in the distance between tropocollagen molecules can be responsible for the experimentally observed effect. We also hypothesize that collagen type V, which co-assembles with collagen type I into heterotypic fibrils in cornea, could be involved in the observed shortening of the corneal D-period.

  4. Effect of oil and shortening in rice bread quality: Relationship between dough rheology and quality characteristics.

    Mancebo, Camino M; Martínez, Mario M; Merino, Cristina; de la Hera, Esther; Gómez, Manuel


    One of the main problems with gluten-free breads is their texture and their rapid staling. Fats are widely used for the improvement of texture and other quality parameters in gluten-free breads. The effect of oil and shortening in rice-breads quality and its correlation with dough rheology has been analyzed. The inclusion of oil increased the specific volume of the breads and reduced their hardness, particularly with lower levels of hydration, whereas shortening did not modify specific volume or reduced it when hydration levels were higher. Oil, at levels of up to 30%, reduced the cohesiveness, springiness and resilience of breads, as well as the brightness of the crust, and increased the a* and b* values. Breads with oil also exhibited a greater number of pores per cm(2) , especially in doughs with higher levels of hydration. An inverse correlation between G' and G'' and bread specific volume has been observed, being the reciprocal-Y model a better predictor than the linear model to relate the bread specific volume. This study showed that the type and quantity of fat added in rice based breads affect the bread quality in a different way. In general, it can be said that the incorporation of up to 20% oil improved rice based breads. Oil increased the specific volume, the a* and b* parameters of the crust and the cell density. It also decreases hardness, cohesiveness, springiness, resilience, and the L* parameter. Converse to breads made with oil, the addition of shortening can negatively affect the quality of the breads. Moreover, the correlation analysis has demonstrated that the study of dough rheology could be a good predictor of gluten-free bread quality. © 2017 Wiley Periodicals, Inc.

  5. Telomere longitudinal shortening as a biomarker for dementia status of adults with Down syndrome.

    Jenkins, Edmund C; Ye, Lingling; Krinsky-McHale, Sharon J; Zigman, Warren B; Schupf, Nicole; Silverman, Wayne P


    Previous studies have suggested that Alzheimer's disease (AD) causes an accelerated shortening of telomeres, the ends of chromosomes consisting of highly conserved TTAGGG repeats that, because of unidirectional 5'-3' DNA synthesis, lose end point material with each cell division. Our own previous work suggested that telomere length of T-lymphocytes might be a remarkably accurate biomarker for "mild cognitive impairment" in adults with Down syndrome (MCI-DS), a population at dramatically high risk for AD. To verify that the progression of cognitive and functional losses due to AD produced this observed telomere shortening, we have now examined sequential changes in telomere length in five individuals with Down syndrome (3F, 2M) as they transitioned from preclinical AD to MCI-DS (N = 4) or dementia (N = 1). As in our previous studies, we used PNA (peptide nucleic acid) probes for telomeres and the chromosome 2 centromere (as an "internal standard" expected to be unaffected by aging or dementia status), with samples from the same individuals now collected prior to and following development of MCI-DS or dementia. Consistent shortening of telomere length was observed over time. Further comparisons with our previous cross-sectional findings indicated that telomere lengths prior to clinical decline were similar to those of other adults with Down syndrome (DS) who have not experienced clinical decline while telomere lengths following transition to MCI-DS or dementia in the current study were comparable to those of other adults with DS who have developed MCI-DS or dementia. Taken together, findings indicate that telomere length has significant promise as a biomarker of clinical progression of AD for adults with DS, and further longitudinal studies of a larger sample of individuals with DS are clearly warranted to validate these findings and determine if and how factors affecting AD risk also influence these measures of telomere length.

  6. Cost and cost-effectiveness of tuberculosis treatment shortening: a model-based analysis.

    Gomez, G B; Dowdy, D W; Bastos, M L; Zwerling, A; Sweeney, S; Foster, N; Trajman, A; Islam, M A; Kapiga, S; Sinanovic, E; Knight, G M; White, R G; Wells, W A; Cobelens, F G; Vassall, A


    Despite improvements in treatment success rates for tuberculosis (TB), current six-month regimen duration remains a challenge for many National TB Programmes, health systems, and patients. There is increasing investment in the development of shortened regimens with a number of candidates in phase 3 trials. We developed an individual-based decision analytic model to assess the cost-effectiveness of a hypothetical four-month regimen for first-line treatment of TB, assuming non-inferiority to current regimens of six-month duration. The model was populated using extensive, empirically-collected data to estimate the economic impact on both health systems and patients of regimen shortening for first-line TB treatment in South Africa, Brazil, Bangladesh, and Tanzania. We explicitly considered 'real world' constraints such as sub-optimal guideline adherence. From a societal perspective, a shortened regimen, priced at USD1 per day, could be a cost-saving option in South Africa, Brazil, and Tanzania, but would not be cost-effective in Bangladesh when compared to one gross domestic product (GDP) per capita. Incorporating 'real world' constraints reduces cost-effectiveness. Patient-incurred costs could be reduced in all settings. From a health service perspective, increased drug costs need to be balanced against decreased delivery costs. The new regimen would remain a cost-effective option, when compared to each countries' GDP per capita, even if new drugs cost up to USD7.5 and USD53.8 per day in South Africa and Brazil; this threshold was above USD1 in Tanzania and under USD1 in Bangladesh. Reducing the duration of first-line TB treatment has the potential for substantial economic gains from a patient perspective. The potential economic gains for health services may also be important, but will be context-specific and dependent on the appropriate pricing of any new regimen.

  7. Incorporated fish oil fatty acids prevent action potential shortening induced by circulating fish oil fatty acids

    Hester M Den Ruijter


    Full Text Available Increased consumption of fatty fish, rich in omega-3 polyunsaturated fatty acids (3-PUFAs reduces the severity and number of arrhythmias. Long term 3-PUFA-intake modulates the activity of several cardiac ion channels leading to cardiac action potential shortening. Circulating 3-PUFAs in the bloodstream and incorporated 3-PUFAs in the cardiac membrane have a different mechanism to shorten the action potential. It is, however, unknown whether circulating 3-PUFAs in the bloodstream enhance or diminish the effects of incorporated 3-PUFAs. In the present study, we address this issue. Rabbits were fed a diet rich in fish oil (3 or sunflower oil (9, as control for 3 weeks. Ventricular myocytes were isolated by enzymatic dissociation and action potentials were measured using the perforated patch clamp technique in the absence and presence of acutely administered 3-PUFAs. Plasma of 3 fed rabbits contained more free eicosapentaenoic acid (EPA and isolated myocytes of 3 fed rabbits contained higher amounts of both EPA and docosahexaenoic acid (DHA in their sarcolemma compared to control. In the absence of acutely administered fatty acids, 3 myocytes had a shorter action potential with a more negative plateau than 9 myocytes. In the 9 myocytes, but not in the 3 myocytes, acute administration of a mixture of EPA+DHA shortened the action potential significantly. From these data we conclude that incorporated 3-PUFAs into the sarcolemma and acutely administered 3 fatty acids do not have a cumulative effect on action potential duration and morphology. As a consequence, patients with a high cardiac 3-PUFA status will probably not benefit from short term 3 supplementation as an antiarrhythmic therapy.

  8. Mid-term clinical outcome of radial shortening for kienbock disease

    Mohammad H Ebrahimzadeh


    Full Text Available Background: To evaluate the intermediate-term outcomes of radius shortening as a treatment for Kienbock′s disease. Materials and Methods: In a historical cohort, 16 skeletally mature patients (9 men and 7 women with Kienbock disease, who were treated with radial shortening osteotomy between 2002 and 2012, were reviewed in our study. The mean age of our patients was 30 (range 18-43 years old. According to Litchman staging, there were 7 wrists at stage II and 9 wrists at stage III (6 at stage IIIA and 3 at stage IIIB. The data of grip strength, pain (visual analog scale (VAS score, wrist range of motion (ROM, ulnar variance (according to Palmer method, and the Lichtman stage were gathered before and after surgery. We evaluated overall wrist function using the Mayo Wrist score and disabilities of the arm shoulder and hand (DASH score before surgery and at the last follow-up. Results: The average of follow-up was 7 years (range from 5 to 9 years. Preoperative ulnar variance was -1.3 mm (range from 2.5 to 1 preoperatively. The mean postoperative ulnar variance was 1 mm positive (range from 0.5 to 1.5. The VAS pain score, the mean arc of wrist flexion and extension, and grip strength improved significantly preoperatively compared to after recovery from surgery. The Lichtman stage was unchanged in nine patients, one grade worse in six patients, and one grade better in one patient. The mean DASH and Mayo scores improved significantly postoperatively compare with preoperation. Comparing preoperative positive, neuter, and negative ulnar variance, there was no significant difference in terms of VAS, DASH, and Mayo scores as well as ROM and grip strength. Conclusion: Our study shows that radius shortening surgery improves pain and disability regardless of ulnar variance.

  9. Human probing behavior of Aedes aegypti when infected with a life-shortening strain of Wolbachia.

    Luciano A Moreira

    Full Text Available BACKGROUND: Mosquitoes are vectors of many serious pathogens in tropical and sub-tropical countries. Current control strategies almost entirely rely upon insecticides, which increasingly face the problems of high cost, increasing mosquito resistance and negative effects on non-target organisms. Alternative strategies include the proposed use of inherited life-shortening agents, such as the Wolbachia bacterium. By shortening mosquito vector lifespan, Wolbachia could potentially reduce the vectorial capacity of mosquito populations. We have recently been able to stably transinfect Aedes aegypti mosquitoes with the life-shortening Wolbachia strain wMelPop, and are assessing various aspects of its interaction with the mosquito host to determine its likely impact on pathogen transmission as well as its potential ability to invade A. aegypti populations. METHODOLOGY/PRINCIPAL FINDINGS: Here we have examined the probing behavior of Wolbachia-infected mosquitoes in an attempt to understand both the broader impact of Wolbachia infection on mosquito biology and, in particular, vectorial capacity. The probing behavior of wMelPop-infected mosquitoes at four adult ages was examined and compared to uninfected controls during video-recorded feeding trials on a human hand. Wolbachia-positive insects, from 15 days of age, showed a drastic increase in the time spent pre-probing and probing relative to uninfected controls. Two other important features for blood feeding, saliva volume and apyrase content of saliva, were also studied. CONCLUSIONS/SIGNIFICANCE: As A. aegypti infected with wMelPop age, they show increasing difficulty in completing the process of blood feeding effectively and efficiently. Wolbachia-infected mosquitoes on average produced smaller volumes of saliva that still contained the same amount of apyrase activity as uninfected mosquitoes. These effects on blood feeding behavior may reduce vectorial capacity and point to underlying physiological

  10. Varying mechanical coupling along the Andean margin: Implications for trench curvature, shortening and topography

    Iaffaldano, G.; Di Giuseppe, E.; Corbi, F.; Funiciello, F.; Faccenna, C.; Bunge, H.-P.


    Convergent margins often exhibit spatial and temporal correlations between trench curvature, overriding plate shortening and topography uplift that provide insights into the dynamics of subduction. The Andean system, where the Nazca plate plunges beneath continental South America, is commonly regarded as the archetype of this class of tectonics systems. There is distinctive evidence that the degree of mechanical coupling between converging plates, i.e. the amount of resistive force mutually transmitted in the direction opposite to their motions, may be at the present-day significantly higher along the central Andean margin compared to the northern and southern limbs. However quantitative estimates of such resistance are still missing and would be desirable. Here we present laboratory models of subduction performed to investigate quantitatively how strong lateral coupling variations need to be to result in trench curvature, tectonic shortening and distribution of topography comparable to estimates from the Andean margin. The analogue of a two-layers Newtonian lithosphere/upper mantle system is established in a silicone putty/glucose syrup tank-model where lateral coupling variations along the interface between subducting and overriding plates are pre-imposed. Despite the simplicity of our setup, we estimate that coupling in the central margin as large as 20% of the driving force is sufficient to significantly inhibit the ability of the experimental overriding plate to slide above the subducting one. As a consequence, the central margin deforms and shortens more than elsewhere while the trench remains stationary, as opposed to the advancing lateral limbs. This causes the margin to evolve into a peculiar shape similar to the present-day trench of the Andean system.

  11. [The probiotic yogurt Activia shortens intestinal transit, but has not been shown to promote defecation].

    Katan, M B


    Activia is a yogurt product containing the probiotic bacterium Bifidobacterium animalis DN-173 010. Five clinical trials have been carried out. Four of these show that dairy products containing this bacterium shorten intestinal transit in volunteers. However, except in a subgroup of 19 out of 267 patients in one study, no significant effect of Activia was reported on the frequency, quantity or consistency of stools. In its marketing in the Netherlands, the company that produces Activia, Danone, claims that Activia promotes defecation. There is insufficient scientific evidence to support this claim.

  12. Effective shortening of picosecond pulses emitted by a YAG:Nd/sup 3 +/ laser

    Dianov, E.M.; Karasik, A.Y.; Mamyshev, P.V.; Onishchukov, G.I.; Prokhorov, A.M.; Stel' makh, M.F.; Fomichev, A.A.


    A 15-fold reduction in the duration of YAG:Nd/sup 3 +/ laser pulses was achieved under conditions of active mode locking and Q switching at a pulse repetition frequency approx.1 kHz. Phase self-modulation in a single-mode quartz fiber waveguide of length 10 m resulted in broadening of the laser emission spectrum right up to approx.10 cm/sup -1/ at the waveguide exit. The pulses were then shortened in a system with a diffraction grating. The pulse duration was measured by a correlation system in which the second harmonic was generated.

  13. Shortened constraint-induced movement therapy in subacute stroke - no effect of using a restraint

    Brogårdh, Christina; Vestling, Monika; Sjölund, Bengt H


    OBJECTIVE: To examine the effect of using a mitt during shortened constraint-induced movement therapy for patients in the subacute phase after stroke. SUBJECTS: Twenty-four patients with stroke (mean age 57.6 (standard deviation (SD) 8.5) years; average 7 weeks post-stroke) with mild to moderate......, no statistically significant differences between the groups were found in any measures at any point in time. CONCLUSION: In this study, no effect of using a restraint in patients with subacute stroke was found. Thus, this component in the constraint-induced therapy concept seems to be of minor importance...

  14. Single clear corneal incision for glaucoma drainage device shortening in pediatric glaucoma.

    Radke, Phillip M; Bitrian, Elena; Grajewski, Alana L


    Glaucoma drainage devices are commonly used for management of glaucoma in adults and children. With time, the position of the tube can change and cause damage such as corneal scarring, iris or lens contact, and uveitis. Most of these problems can be improved with tube shortening and/or excision of adherent iris or fibrous tissue. We describe a surgical technique that uses a single clear corneal incision to externalize and trim the shunt in pediatric patients. The technique has a short surgical. We review the indications and outcomes for this procedure in 13 eyes of 12 children who required shunt revision.

  15. [Carotid endarterectomy. Experiences with shortening of interval between symptom and operation

    Rathenborg, L.K.; Baekgaard, N.; Jensen, Leif Pandora


    and in the neurological departments. The stroke and death rate was unchanged, 4% and 3% before and after fast track respectively. CONCLUSION: The time between symptom and CEA can be shortened by means of a fast track after thorough information and reorganization of the work involving these patients. In order to bring......INTRODUCTION: Carotid endarterectomy (CEA) prevents transient ischemic attack and stroke in patients with symptomatic high-grade carotid stenosis. In 2004 Rothwell et al showed that maximal benefit is gained if CEA is performed less than three weeks after the onset of the symptom. With the aim...

  16. Depth oriented brief therapy: an ideal technique as hospice lengths-of-stay continue to shorten.

    Thomson, Judith E; Jordan, Merle R


    The authors note that as hospice patients' lengths-of-stay continue to shorten, psychosocial/spiritual counselors are being challenged to help patients and families process the myriad of issues terminal illness gives rise to. Given this reality, the authors suggest that the Depth Oriented Brief Therapy (DOBT) approach should prove especially useful. The DOBT premise is that if people can be helped to experience the emotional meanings of why they hold on to emotionally painful symptoms then they can abandon their symptoms for healthier ways of being.

  17. Lactose tolerance test shortened to 30 minutes: an exploratory study of its feasibility and impact

    José Luis Domínguez-Jiménez


    Full Text Available Introduction: Lactose malabsorption (LM is a very common condition with a high prevalence in our setting. Lactose tolerance test (LTT is a basic, affordable test for diagnosis that requires no complex technology. It has been recently shown that this test can be shortened to 3 measurements (baseline, 30 min, 60 min with no impact on final results. The purpose of our study was to assess the feasibility and benefits of LTT simplification and shortening to 30 min, as well as the financial impact entailed. Material and methods: A multicenter, observational study of consecutive patients undergoing LTT for LM suspicion. Patients received 50 g of lactose following a fasting period of 12 h, and had blood collected from a vein at all 3 time points for the measurement of blood glucose (mg/dl. Differences between the shortened and complete test forms were analyzed using McNemar's test. A comparison of blood glucose levels between patients with normal and abnormal results was performed using Student's T-test for independent mean values. Consistency was assessed using the kappa index. A p < 0.05 was considered to be statistically significant. Results: A total of 270 patients (69.6% females were included, with a mean age of 39.9 ± 16 years. LTT was abnormal for 151 patients (55.9%. We observed no statistically significant differences in baseline blood glucose levels between patients with normal and abnormal LTT results (p = 0.13; however, as was to be expected, such differences were obvious for the remaining time points (p < 0.01. Deleting blood glucose measurements at 60 minutes only led to overdiagnose LM (false positive results in 6 patients (2.22 %, with a kappa index of 0.95 (95% CI: 0.92-0.99 (p < 0.001 versus the complete test. Suppressing measurements at 60 min would have saved at least € 7,726. Conclusion: The shortening of LTT to only 2 measurements (baseline and 30-min hardly leads to any differences in final results, and would entail savings in

  18. Neutrino Velocity and Neutrino Oscillations

    Minakata, H


    We study distances of propagation and the group velocities of the muon neutrinos in the presence of mixing and oscillations assuming that Lorentz invariance holds. Oscillations lead to distortion of the $\

  19. Statistics of Centroids of Velocity

    Esquivel, A


    We review the use of velocity centroids statistics to recover information of interstellar turbulence from observations. Velocity centroids have been used for a long time now to retrieve information about the scaling properties of the turbulent velocity field in the interstellar medium. We show that, while they are useful to study subsonic turbulence, they do not trace the statistics of velocity in supersonic turbulence, because they are highly influenced by fluctuations of density. We show also that for sub-Alfv\\'enic turbulence (both supersonic and subsonic) two-point statistics (e.g. correlation functions or power-spectra) are anisotropic. This anisotropy can be used to determine the direction of the mean magnetic field projected in the plane of the sky.

  20. Maximum orbit plane change with heat-transfer-rate considerations

    Lee, J. Y.; Hull, D. G.


    Two aerodynamic maneuvers are considered for maximizing the plane change of a circular orbit: gliding flight with a maximum thrust segment to regain lost energy (aeroglide) and constant altitude cruise with the thrust being used to cancel the drag and maintain a high energy level (aerocruise). In both cases, the stagnation heating rate is limited. For aeroglide, the controls are the angle of attack, the bank angle, the time at which the burn begins, and the length of the burn. For aerocruise, the maneuver is divided into three segments: descent, cruise, and ascent. During descent the thrust is zero, and the controls are the angle of attack and the bank angle. During cruise, the only control is the assumed-constant angle of attack. During ascent, a maximum thrust segment is used to restore lost energy, and the controls are the angle of attack and bank angle. The optimization problems are solved with a nonlinear programming code known as GRG2. Numerical results for the Maneuverable Re-entry Research Vehicle with a heating-rate limit of 100 Btu/ft(2)-s show that aerocruise gives a maximum plane change of 2 deg, which is only 1 deg larger than that of aeroglide. On the other hand, even though aerocruise requires two thrust levels, the cruise characteristics of constant altitude, velocity, thrust, and angle of attack are easy to control.

  1. Soil Properties from Low-Velocity Probe Penetration

    Jerome B. Johnson


    Full Text Available A physical model of low-velocity probe penetration is developed to characterize soil by type, strength, maximum compaction, and initial density using Newton's second law to describe the processes controlling probe momentum loss. The probe loses momentum by causing soil failure (strength, accelerating and compacting soil around the probe (inertia, and through frictional sliding at the probe/soil interface (friction. Probe geometry, mass, and impact velocity influences are incorporated into the model. Model predictions of probe deceleration history and depth of penetration agree well with experiments, without the need for free variables or complex numerical simulations.

  2. Kriging interpolating cosmic velocity field

    Yu, Yu; Zhang, Jun; Jing, Yipeng; Zhang, Pengjie


    Volume-weighted statistics of large-scale peculiar velocity is preferred by peculiar velocity cosmology, since it is free of the uncertainties of galaxy density bias entangled in observed number density-weighted statistics. However, measuring the volume-weighted velocity statistics from galaxy (halo/simulation particle) velocity data is challenging. Therefore, the exploration of velocity assignment methods with well-controlled sampling artifacts is of great importance. For the first time, we apply the Kriging interpolation to obtain the volume-weighted velocity field. Kriging is a minimum variance estimator. It predicts the most likely velocity for each place based on the velocity at other places. We test the performance of Kriging quantified by the E-mode velocity power spectrum from simulations. Dependences on the variogram prior used in Kriging, the number nk of the nearby particles to interpolate, and the density nP of the observed sample are investigated. First, we find that Kriging induces 1% and 3% systematics at k ˜0.1 h Mpc-1 when nP˜6 ×1 0-2(h-1 Mpc )-3 and nP˜6 ×1 0-3(h-1 Mpc )-3 , respectively. The deviation increases for decreasing nP and increasing k . When nP≲6 ×1 0-4(h-1 Mpc )-3 , a smoothing effect dominates small scales, causing significant underestimation of the velocity power spectrum. Second, increasing nk helps to recover small-scale power. However, for nP≲6 ×1 0-4(h-1 Mpc )-3 cases, the recovery is limited. Finally, Kriging is more sensitive to the variogram prior for a lower sample density. The most straightforward application of Kriging on the cosmic velocity field does not show obvious advantages over the nearest-particle method [Y. Zheng, P. Zhang, Y. Jing, W. Lin, and J. Pan, Phys. Rev. D 88, 103510 (2013)] and could not be directly applied to cosmology so far. However, whether potential improvements may be achieved by more delicate versions of Kriging is worth further investigation.

  3. Event Detection by Velocity Pyramid


    In this paper, we propose velocity pyramid for multimediaevent detection. Recently, spatial pyramid matching is proposed to in-troduce coarse geometric information into Bag of Features framework,and is eective for static image recognition and detection. In video, notonly spatial information but also temporal information, which repre-sents its dynamic nature, is important. In order to fully utilize it, wepropose velocity pyramid where video frames are divided into motionalsub-regions. Our meth...

  4. Generalised maximum entropy and heterogeneous technologies

    Oude Lansink, A.G.J.M.


    Generalised maximum entropy methods are used to estimate a dual model of production on panel data of Dutch cash crop farms over the period 1970-1992. The generalised maximum entropy approach allows a coherent system of input demand and output supply equations to be estimated for each farm in the sam

  5. 20 CFR 229.48 - Family maximum.


    ... month on one person's earnings record is limited. This limited amount is called the family maximum. The family maximum used to adjust the social security overall minimum rate is based on the employee's Overall..., when any of the persons entitled to benefits on the insured individual's compensation would, except...

  6. Two-stage revision of infected hip arthroplasty using a shortened post-operative course of antibiotics.

    McKenna, Paul B


    We present a series of 30 consecutive patients with 31 infected total hip arthroplasties treated by a single surgeon over a 4-year period in whom a shortened post-operative course of antimicrobial chemotherapy was used.

  7. Effects of removable dental prostheses on masticatory performance of subjects with shortened dental arches: A systematic review

    Liang, S.; Zhang, Q.; Witter, D.J.; Wang, Y.; Creugers, N.H.J.


    OBJECTIVE: To synthesise data on the effects of distal-extension removable dental prostheses (RDPs) on masticatory performance of subjects with (extreme) shortened dental arches ((E)SDAs). DATA: Search terms were: 'masticatory' respectively 'chewing' combined with 'performance', 'efficiency', or

  8. A Load Balancing Algorithm Based on Maximum Entropy Methods in Homogeneous Clusters

    Long Chen


    Full Text Available In order to solve the problems of ill-balanced task allocation, long response time, low throughput rate and poor performance when the cluster system is assigning tasks, we introduce the concept of entropy in thermodynamics into load balancing algorithms. This paper proposes a new load balancing algorithm for homogeneous clusters based on the Maximum Entropy Method (MEM. By calculating the entropy of the system and using the maximum entropy principle to ensure that each scheduling and migration is performed following the increasing tendency of the entropy, the system can achieve the load balancing status as soon as possible, shorten the task execution time and enable high performance. The result of simulation experiments show that this algorithm is more advanced when it comes to the time and extent of the load balance of the homogeneous cluster system compared with traditional algorithms. It also provides novel thoughts of solutions for the load balancing problem of the homogeneous cluster system.

  9. Speed Estimation in Geared Wind Turbines Using the Maximum Correlation Coefficient

    Skrimpas, Georgios Alexandros; Marhadi, Kun S.; Jensen, Bogi Bech;


    to overcome the above mentioned issues. The high speed stage shaft angular velocity is calculated based on the maximum correlation coefficient between the 1 st gear mesh frequency of the last gearbox stage and a pure sinus tone of known frequency and phase. The proposed algorithm utilizes vibration signals...

  10. Critical velocity and lactate threshold in young swimmers.

    Toubekis, A G; Tsami, A P; Tokmakidis, S P


    The purpose of the present study was to compare the critical swimming velocity (CV) in children, with the lactate threshold (LT) and the velocity corresponding to a blood lactate concentration of 4 mmol x l(-1) (V4). Twenty swimmers (ten females and ten males, mean +/- SD age: 12.9 +/- 1.1 years, body weight: 51.2 +/- 10.0 kg, height: 157.1 +/- 9.7 cm) performed four repetitions of 200 m swimming with increasing intensity (80, 85, 90 and 100% of their 200 m maximum velocity), interspersed with 15 minutes of passive rest. Blood lactate concentration was determined after each repetition. From the speed-lactate curve, the velocity corresponding to LT and V4 was calculated. In order to calculate CV, all swimmers were timed exerting maximum effort, on distances of 50, 100, 200 and 400 m. CV was expressed as the slope of the linear relationship of time versus distance and was calculated from combinations of four (CV4) three or two timed distances. Velocity on LT (1.079 +/- 0.114 m x s(-1)) and V4 (1.106 +/- 0.112 m x s(-1)) was comparable to CV4 (1.085 +/- 0.121 m x s(-1)). CV calculated from a combination including distances of 50, 100 or 200 m were higher compared to LT (p velocities (p critical velocity seems to be a valid, practical and time-saving, non-invasive alternative method which can be applied in the swimming pool by a coach for the evaluation of the endurance capacity of young swimmers. For practical reasons, combinations of less than four distances can be used (i.e. 50-400 m, or 50-100-400 m).

  11. Spatiotemporal variations in the surface velocities of Antarctic Peninsula glaciers

    J. Chen


    Full Text Available Velocity is an important parameter for the estimation of glacier mass balance, which directly signals the response of glaciers to climate change. Antarctic ice sheet movement and the associated spatiotemporal velocity variations are of great significance to global sea level rise. In this study, we estimate Antarctic Peninsula glacier velocities using the co-registration of optically sensed images and correlation (hereafter referred to as COSI-Corr based on moderate-resolution imaging spectroradiometer Level 1B data (hereafter referred to as MODIS L1B. The results show that the glaciers of Graham Land and the Larsen Ice Shelf have substantially different velocity features. The Graham Land glaciers primarily flow from the peninsula ridge towards the Weddell Sea and Bellingshausen Sea on the east and west sides, respectively. There are very large velocity variations among the different ice streams, with a minimum of −1 and a maximum of 1500 m a−1 (with an average of 100–150 m a−1. Over the period 2000–2012, the glaciers of Graham Land accelerated in the south but slowed down in the north. In contrast, the Larsen Ice Shelf flows in a relatively uniform direction, mainly towards the northeast into the Weddell Sea. Its average velocity is 750–800 m a−1 and the maximum is > 1500 m a−1. During the period 2000–2012, the Larsen Ice Shelf experienced significant acceleration. The use of COSI-Corr based on MODIS L1B data is suitable for glacier velocity monitoring on the Antarctic Peninsula over long time series and large spatial scales. This method is clearly advantageous for analysing macro-scale spatiotemporal variations in glacier movement.

  12. Duality of Maximum Entropy and Minimum Divergence

    Shinto Eguchi


    Full Text Available We discuss a special class of generalized divergence measures by the use of generator functions. Any divergence measure in the class is separated into the difference between cross and diagonal entropy. The diagonal entropy measure in the class associates with a model of maximum entropy distributions; the divergence measure leads to statistical estimation via minimization, for arbitrarily giving a statistical model. The dualistic relationship between the maximum entropy model and the minimum divergence estimation is explored in the framework of information geometry. The model of maximum entropy distributions is characterized to be totally geodesic with respect to the linear connection associated with the divergence. A natural extension for the classical theory for the maximum likelihood method under the maximum entropy model in terms of the Boltzmann-Gibbs-Shannon entropy is given. We discuss the duality in detail for Tsallis entropy as a typical example.

  13. In-treatment midwall and endocardial fractional shortening predict cardiovascular outcome in hypertensive patients with preserved baseline systolic ventricular function: the Losartan Intervention For Endpoint reduction study

    Wachtell, Kristian; Gerdts, Eva; Palmieri, Vittorio;


    Endocardial fractional shortening (EFS) and midwall shortening (MWS) are impaired in patients with left ventricular hypertrophy. However, it remains unknown whether improvement of left ventricular systolic function during treatment reduces cardiovascular morbidity and mortality in hypertensive pa...

  14. Shortening spinal column reconstruction through posterior only approach for the treatment of unstable osteoporotic burst lumber fracture: a case report

    Shawky, Ahmed; Kroeber, Markus


    Study design Case report. Clinical question This study reports if shortening reconstruction procedure through posterior approach only can be used in osteoporotic unstable fracture as well as post-traumatic burst fracture. Methods An 80-year-old female patient with unstable burst osteoporotic fracture of L1 underwent posterior approach corpectomy and shortening reconstruction of the spinal column by non-expandable cages. Result The surgery was uneventful, with average blood loss. Using of smal...

  15. Comparison of hydrogenated vegetable shortening and nutritionally complete high fat diet on limited access-binge behavior in rats

    Davis, Jon F.; Melhorn, Susan J; Heiman, Justin U.; Tschöp, Matthias H.; Clegg, Deborah J.; Benoit, Stephen C.


    Previous studies have suggested that intermittent exposure to hydrogenated vegetable shortening yields a binge/compensate pattern of feeding in rats. The present study was designed to assess whether rats would exhibit similar patterns of intake when given intermittent access to a nutritionally complete high-fat diet. Four groups of rats received varying exposure to either hydrogenated vegetable shortening or high-fat diet for 8 consecutive weeks. Animals were given daily and intermittent acce...

  16. Mechanical versus kinematical shortening reconstructions of the Zagros High Folded Zone (Kurdistan region of Iraq)

    Frehner, Marcel; Reif, Daniel; Grasemann, Bernhard


    This paper compares kinematical and mechanical techniques for the palinspastic reconstruction of folded cross sections in collision orogens. The studied area and the reconstructed NE-SW trending, 55.5 km long cross section is located in the High Folded Zone of the Zagros fold-and-thrust belt in the Kurdistan region of Iraq. The present-day geometry of the cross section has been constructed from field as well as remote sensing data. In a first step, the structures and the stratigraphy are simplified and summarized in eight units trying to identify the main geometric and mechanical parameters. In a second step, the shortening is kinematically estimated using the dip domain method to 11%-15%. Then the same cross section is used in a numerical finite element model to perform dynamical unfolding simulations taking various rheological parameters into account. The main factor allowing for an efficient dynamic unfolding is the presence of interfacial slip conditions between the mechanically strong units. Other factors, such as Newtonian versus power law viscous rheology or the presence of a basement, affect the numerical simulations much less strongly. If interfacial slip is accounted for, fold amplitudes are reduced efficiently during the dynamical unfolding simulations, while welded layer interfaces lead to unrealistic shortening estimates. It is suggested that interfacial slip and decoupling of the deformation along detachment horizons is an important mechanical parameter that controlled the folding processes in the Zagros High Folded Zone.

  17. Increasing flux rate to shorten leaching period and ramp-up production

    Ngantung, Billy; Agustin, Riska; Ravi'i


    J Resources Bolaang Mongondow (JBRM) has operated a dynamic heap leach in its Bakan Gold Mine since late 2013. After successfully surpassing its name plate capacity of 2.6 MT/annum in 2014, the clayey and transition ore become the next operational challenge. The presence of transition and clayey ore requires longer leaching period, hence reducing the leach pad capacity which then caused reduced production. Maintaining or even increasing production with such longer leaching ore types can be done by expanding the leach pad area which means an additional capital investment, and/or shortening the leaching cycle which compromise a portion of gold extraction. JBRM has been successfully increasing the leach pad production from 2.6 MT/annum to 3.8 MT/annum, whilst improving the gold extraction from around 70% to around 80%. This was achieved by managing the operation of the leach pad which is shortening the leach cycle by identifying and combining the optimal flux rate application versus the tonne processed in each cell, at no capital investment for expanding the cell capacity.

  18. Immediate liposuction could shorten the time for endoscopic axillary lymphadenectomy in breast cancer patients.

    Shi, Fujun; Huang, Zonghai; Yu, Jinlong; Zhang, Pusheng; Deng, Jianwen; Zou, Linhan; Zhang, Cheng; Luo, Yunfeng


    Endoscopic axillary lymphadenectomy (EALND) was introduced to clinical work to reduce side effects of conventional axillary lymphadenectomy, while the lipolysis and liposuction of EALND made the process consume more time. The aim of the study was to determine whether immediate liposuction after tumescent solution injection to the axilla could shorten the total time of EALND. Fifty-nine patients were enrolled in the study, 30 of them received EALND with traditional liposuction method (TLM), and the rest 29 patients received EALND with immediate liposuction method (ILM). The operation time, cosmetic result, drainage amount, and hospitalization time of the two groups were compared. The median EALND operation time of TLM group and ILM group were 68 and 46 min, respectively, the difference was significant (P  0.05). Our work suggests immediate liposuction could shorten the endoscopic axillary lymphadenectomy process, and this method would not compromise the operation results. However, due to the limitations of the research, more work needs to be done to prove the availability and feasibility of immediate liposuction.

  19. Analysis of modulation factor to shorten the delivery time in helical tomotherapy.

    Shimizu, Hidetoshi; Sasaki, Koji; Tachibana, Hiroyuki; Tomita, Natsuo; Makita, Chiyoko; Nakashima, Kuniyasu; Yokoi, Kazushi; Kubota, Takashi; Yoshimoto, Manabu; Iwata, Tohru; Kodaira, Takeshi


    A low modulation factor (MF) maintaining a good dose distribution contributes to the shortening of the delivery time and efficiency of the treatment plan in helical tomotherapy. The purpose of this study was to reduce the delivery time using initial values and the upper limit values of MF. First, patients with head and neck cancer (293 cases) or prostate cancer (181 cases) treated between June 2011 and July 2015 were included in the analysis of MF values. The initial MF value (MFinitial ) was defined as the average MFactual value, and the upper limit of the MF value (MFUL ) was defined according the following equation: MFUL = 2 × standard deviation of MFactual value + the average MFactual Next, a treatment plan was designed for patients with head and neck cancer (62 cases) and prostate cancer (13 cases) treated between December 2015 and June 2016. The average MFactual value for the nasopharynx, oropharynx, hypopharynx, and prostate cases decreased from 2.1 to 1.9 (p = 0.0006), 1.9 to 1.6 (p delivery time for the nasopharynx, oropharynx, hypopharynx, and prostate cases also decreased from 19.9 s cm(-1) to 16.7 s cm(-1) (p delivery time was shortened by the adaptation of MFinitial and MFUL values with a reduction in the average MFactual for head and neck cancer and prostate cancer cases. © 2017 The Authors. Journal of Applied Clinical Medical Physics published by Wiley Periodicals, Inc. on behalf of American Association of Physicists in Medicine.

  20. Hsp25 and Hsp72 content in rat skeletal muscle following controlled shortening and lengthening contractions.

    Holwerda, Andrew M; Locke, Marius


    The cytoprotective proteins, Hsp25 and Hsp72, are increased in skeletal muscle after nondamaging, shortening contractions, but the temporal pattern of expression and stimulatory mechanisms remain unclear. Thus, we sought to define the in vivo temporal patterns of expression for Hsp25 and Hsp72 after 2 opposing contractions types. To do this, male Sprague-Dawley rats had 1 tibialis anterior (TA) muscle electrically stimulated (5 sets of 20 repetitions) while being either forcibly lengthened (LC) or shortened (SC). At 2, 8, 24, 48, 72, or 168 h after the contractions both the stimulated and the nonstimulated (contra-lateral control) TA muscles were removed and processed to examine muscle damage (hemotoxylin and eosin staining) and Hsp content (Western blot analyses). Cross-sections from TA muscles subjected to LCs showed muscle fibre damage at 8 h and thereafter. In contrast, no muscle fibre damage was observed at any time point following SCs. When normalized to contra-lateral controls, Hsp25 and Hsp72 content were significantly (P < 0.01) increased at 24 h (3.1- and 3.8-fold, respectively) and thereafter. There were no significant increases in Hsp25 or Hsp72 content at any time point following SC. These data suggest that LCs, but not SCs, result in Hsp accumulation and that the fibre/cellular damage sustained from LCs may be the stimulus for elevating Hsp content.

  1. Diffusional kurtosis MRI of the lower leg: changes caused by passive muscle elongation and shortening.

    Filli, Lukas; Kenkel, David; Wurnig, Moritz C; Boss, Andreas


    Diffusional kurtosis MRI (DKI) quantifies the deviation of water diffusion from a Gaussian distribution. We investigated the influence of passive elongation and shortening of the lower leg muscles on the DKI parameters D (diffusion coefficient) and K (kurtosis). After approval by the local ethics committee, eight healthy volunteers (age, 29.1 ± 2.9 years) underwent MRI of the lower leg at 3 T. Diffusion-weighted images were acquired with 10 different b values at three ankle positions (passive dorsiflexion 10°, neutral position 0°, passive plantar flexion 40°). Parametrical maps of D and K were obtained by voxel-wise fitting of the signal intensities using a non-linear Levenberg-Marquardt algorithm. D and K were measured in the tibialis anterior, medial and lateral gastrocnemius, and soleus muscles. In the neutral position, D and K values were in the range between 1.66-1.79 × 10(-3) mm(2) /s and 0.21-0.39, respectively. D and K increased with passive shortening, and decreased with passive elongation, which could also be illustrated on the parametrical maps. In dorsiflexion, D (p muscles are significantly influenced by the ankle joint position, indicating that the diffusion of water molecules in skeletal muscle deviates from a Gaussian distribution depending on muscle tonus. Copyright © 2016 John Wiley & Sons, Ltd.

  2. Measurement of terrace deformation and crustal shortening of some renascent fold zones within Kalpin nappe structure

    YANG XiaoPing; RAN YongKang; CHENG JianWu; CHEN LiChun; XU XiWei


    The Kalpin nappe structure is a strongest thrust and fold deformation belt in front of the Tianshan Mountains since the Cenozoic time. The tectonic deformation occurred in 5-6 striking Mesozoic-Cenozoic fold zones, and some renascent folds formed on the recent alluvial-proluvial fans in front of the folded mountains. We used the total station to measure gully terraces along the longitudinal topographic profile in the renascent fold zones and collected samples from terrace deposits for age determination. Using the obtained formation time and shortening amount of the deformed terraces, we calculated the shortening rate of 4 renascent folds to be 0.1±0.03 mm/a, 0.12±0.04 mm/a, 0.59±0.18 mm/a, and 0.26±0.08 mm/a, respectively. The formation time of the renascent folds is some later than the major tectonic uplift event of the Qinghai-Tibet Plateau 0.14 Ma ago. It may be the long-distance effect of this tectonic event on the Tianshan piedmont fold belt.

  3. Animal studies of life shortening and cancer risk from space radiation

    Wood, D. H.; Yochmowitz, M. G.; Hardy, K. A.; Salmon, Y. L.

    The U. S. Air Force study of the delayed effects of single, total body exposures to simulated space radiation in rhesus monkeys is now in its 21st year. Observations on 301 irradiated and 57 age-matched control animals indicate that life expectancy loss from exposure to protons in the energy range encountered in the Van Allen belts and solar proton events can be expressed as a logarithmic function of the dose. The primary causes of life shortening are cancer and endometriosis (an abnormal proliferation of the lining of the uterus in females). Life shortening estimates permit comparison of the risk associated with space radiation exposures to be compared with that of other occupational and environmental hazards, thereby facilitating risk/benefit decisions in the planning and operational phases of manned space missions. Calculations of the relative risk of fatal cancers in the irradiated subjects reveal that the total body surface dose required to double the risk of death from cancer over a 20-year post exposure period varies with the linear energy transfer (LET) of the radiation. The ability to determine the integrated dose and LET spectrum in space radiation exposures of human is, therefore, critical to the assessment of life-time cancer risk.

  4. Leucocyte Telomere Shortening in relation to Newly Diagnosed Type 2 Diabetic Patients with Depression

    Zhelong Liu


    Full Text Available The goal of this study is to investigate the association between oxidative stress and telomere length shortening in the comorbid depression and diabetes. Therefore, 71 patients with newly diagnosed type 2 diabetes (T2D and 52 subjects with normal glycemic level (control, Ctrl were enrolled. Depressive status was identified with the Depression Subscale of Hospital Anxiety and Depression Scale (HADS-D. Leukocyte telomere length ratio (T/S ratio was determined with quantitative PCR. Oxidative stress status was evaluated with 8-hydroxy-desoxyguanosine (8-OHdG assay kit. Some other biochemical blood testing was also performed. The data showed that T2D patients had higher proportion of depression evaluated by the HADS-D (x2=4.196, P=0.041. T/S ratio was significantly negatively correlated with 8-OHdG, HADS-D, age, HbA1c, FPG, and HOMA-IR. In addition, HADS-D was significantly positively correlated with HbA1c, FPG, HOMA-IR, and 8-OHdG. Both HADS-D and 8-OHdG were the major independent predictors for T/S ratio. This study indicates that oxidative stress contributes to both telomere length shortening and depression development in newly diagnosed type 2 diabetic patients, while in depression status, some other mechanisms besides oxidative stress may also affect the telomere length.

  5. Moderate stem-cell telomere shortening rate postpones cancer onset in a stochastic model

    Holbek, Simon; Bendtsen, Kristian Moss; Juul, Jeppe


    Mammalian cells are restricted from proliferating indefinitely. Telomeres at the end of each chromosome are shortened at cell division and when they reach a critical length, the cell will enter permanent cell cycle arrest—a state known as senescence. This mechanism is thought to be tumor suppressing, as it helps prevent precancerous cells from dividing uncontrollably. Stem cells express the enzyme telomerase, which elongates the telomeres, thereby postponing senescence. However, unlike germ cells and most types of cancer cells, stem cells only express telomerase at levels insufficient to fully maintain the length of their telomeres, leading to a slow decline in proliferation potential. It is not yet fully understood how this decline influences the risk of cancer and the longevity of the organism. We here develop a stochastic model to explore the role of telomere dynamics in relation to both senescence and cancer. The model describes the accumulation of cancerous mutations in a multicellular organism and creates a coherent theoretical framework for interpreting the results of several recent experiments on telomerase regulation. We demonstrate that the longest average cancer-free lifespan before cancer onset is obtained when stem cells start with relatively long telomeres that are shortened at a steady rate at cell division. Furthermore, the risk of cancer early in life can be reduced by having a short initial telomere length. Finally, our model suggests that evolution will favor a shorter than optimal average cancer-free lifespan in order to postpone cancer onset until late in life.

  6. Shortened telomere length in bipolar disorder: a comparison of the early and late stages of disease

    Florencia M. Barbé-Tuana

    Full Text Available Objective: Bipolar disorder (BD has been associated with increased rates of age-related diseases, such as type II diabetes, metabolic syndrome, osteoporosis, and cardiovascular disorders. Several biological findings have been associated with age-related disorders, including increased oxidative stress, inflammation, and telomere shortening. The objective of this study was to compare telomere length among participants with BD at early and late stages and age- and gender-matched healthy controls. Methods: Twenty-six euthymic subjects with BD and 34 healthy controls were recruited. Genomic DNA was extracted from peripheral blood and mean telomere length was measured using real-time quantitative polymerase chain reaction. Results: Telomere length was significantly shorter in both the early and late subgroups of BD subjects when compared to the respective controls (p = 0.002 and p = 0.005, respectively. The sample size prevented additional subgroup analyses, including potential effects of medication, smoking status, and lifestyle. Conclusion: This study is concordant with previous evidence of telomere shortening in BD, in both early and late stages of the disorder, and supports the notion of accelerated aging in BD.

  7. Dynamic Route Shortening and Route Repairing Mechanism for Mobile Ad Hoc Networks

    T. R. Rangaswamy


    Full Text Available Problem statement: Ad hoc Networks are wireless networks without any fixed infrastructure. The network topology changes frequently and unpredictably due to the random movement of the nodes. The ad hoc on Demand Distant Vector Routing (AODV protocol works in a dynamic fashion, by establishing a route on demand and continues that route until it breaks. Due to the changing network topology of ad hoc networks, if other routes with less hop count become available, the network topology is not able to adapt until the route break occurs. Hence in the route shortening scheme is some redundant nodes in the active route is replaced with a node that is not on the active route. When there is any link failure between any two nodes, the alternative route with optimum route to be constructed and not sending RRER message to the source node to initiate the route discovery process again. Approach: This study proposes a new routing protocol called, Dynamic Route Shortening and Repairing mechanism (DRSR. The route shortening is incorporated with route repairing mechanism, to improve the performance of the AODV. The route shortening scheme works by replacing some redundant nodes in the active route, with a node that is not on the active route. If there is a link failure between the two nodes, the route repairing mechanism repairs the route, by using the nodes that are close enough to the route to overhear the message. Whenever the links go down, the DRSR replaces the failed links with the optimum route that is adjacent to the main route and not sending and RRER message to the source node to initiate the route discovery process again. The alternative route construction process could be initiated at any time, not just when a route has failed. The dynamically constructed alternative route’s information is passed on to the upstream nodes, which then determine by themselves when to direct their packets to the Normal 0 false false false EN-US X

  8. Late Quaternary temperature change velocity in Mesoamerica

    Correa-Metrio, A.; Lozano, S.; Sosa-Nájera, S.; Bush, M. B.


    Quaternary climate has been highly variable, and yet few quantitative continental reconstructions are available for tropical areas. Quantitative records of temperature change during the Quaternary are especially relevant for putting modern climate change into a historic context. Within this perspective, two aspects are of singular relevance: i) Identifying and quantifying past climatic variability, and ii) Providing a means to estimate the seed at which climate change happened in the past. Here we show temperature reconstructions and temperature change velocity calculations for two locations in northern tropical America. Temperature reconstruction was based on two sedimentary records form Lake Chalco (30,000 years), central Mexican highlands, and Lake Petén-Itzá, Guatemalan lowlands (86,000 years). Temperature reconstruction was based on the analysis of fossil pollen on the light of pollen-temperature transfer functions. These functions were calibrated through an extensive survey of modern pollen samples covering an elevational gradient from 0 to 4,218 m asl. Derived temperature profiles show a parallel long-term trend and a similar cooling of approximately 5 oC during the Last Glacial Maximum in the lowlands and highlands of Mexico and Guatemala. Using a digital elevation model, we ere able to reconstruct the velocity at which isotherms displaced to produce the observed temperature anomalies. Spatial velocities of temperature change in the studied areas were at least four times slower than values reported for the last 50 years, but also at least twice as fast as those obtained from recent models. This study demonstrates that modern temperature change has no precedent within the last 86,000 years, but also that tropical climate has been more variable than it has been assumed to date.

  9. Advanced Ice Velocity Mapping Using Landsat 8

    Klinger, M. J.; Scambos, T. A.; Fahnestock, M. A.; Haran, T. M.


    Improved image-to-image cross correlation software is applied to pairs of sequential Landsat 8 satellite imagery to accurately measure ice surface velocity over ice sheets and glaciers (±0.1 pixel displacement, 15 meter pixels). The high radiometric fidelity of Landsat 8's panchromatic band (12-bit), and exceptional geolocation accuracy (typically ±5 m) supports the generation of ice velocity fields over very short time intervals (e.g., 16-, 32-, or 48-day repeat images of the same scene location). The high radiometry supports velocity mapping in areas with very subtle topographic detail, including un-crevassed sastrugi regions on ice dome flanks or the ice sheet interior. New Python-based software presently under development (named PyCorr), takes two sequential Landsat 8 OLI scenes (or suitably processed ETM+ or TM scenes) and matches small sub-scenes ('chips') between the images based on similarity in their gray-scale value patterns, using an image correlation algorithm. Peak fitting in the region of maximum correlation for a chip pair yields sub-pixel fits to the feature offset vector. Vector editing after the image correlation runs seeks to eliminate spurious and cloud-impacted vectors, and correct residual geo-location error. This processing is based on plausible values of ice strain rates and known areas of near-zero ice flow (rock outcrops, ice dome areas, etc.). In preliminary processing, we have examined ~800 Landsat 8 image pairs having <20% cloud cover spanning the near-coastal Antarctic ice sheet during the 2013-14 summer season.

  10. Spectroscopic Observations of SN 2012fr: A Luminous Normal Type Ia Supernova with Early High Velocity Features and Late Velocity Plateau

    Childress, M J; Sim, S A; Tucker, B E; Yuan, F; Schmidt, B P; Cenko, S B; Silverman, J M; Contreras, C; Hsiao, E Y; Phillips, M; Morrell, N; Jha, S W; McCully, C; Filippenko, A V; Anderson, J P; Benetti, S; Bufano, F; de Jaeger, T; Forster, F; Gal-Yam, A; Guillou, L Le; Maguire, K; Maund, J; Mazzali, P A; Pignata, G; Smartt, S; Spyromilio, J; Sullivan, M; Taddia, F; Valenti, S; Bayliss, D D R; Bessell, M; Blanc, G A; Carson, D J; Clubb, K I; de Burgh-Day, C; Desjardins, T D; Fang, J J; Fox, O D; Gates, E L; Ho, I-T; Keller, S; Kelly, P L; Lidman, C; Loaring, N S; Mould, J R; Owers, M; Ozbilgen, S; Pei, L; Pickering, T; Pracy, M B; Rich, J A; Schaefer, B E; Scott, N; Stritzinger, M; Vogt, F P A; Zhou, G


    We present 65 optical spectra of the Type Ia supernova SN 2012fr, of which 33 were obtained before maximum light. At early times SN 2012fr shows clear evidence of a high-velocity feature (HVF) in the Si II 6355 line which can be cleanly decoupled from the lower velocity "photospheric" component. This Si II 6355 HVF fades by phase -5; subsequently, the photospheric component exhibits a very narrow velocity width and remains at a nearly constant velocity of v~12,000 km/s until at least 5 weeks after maximum brightness. The Ca II infrared (IR) triplet exhibits similar evidence for both a photospheric component at v~12,000 km/s with narrow line width and long velocity plateau, as well as a high-velocity component beginning at v~31,000 km/s two weeks before maximum. SN 2012fr resides on the border between the "shallow silicon" and "core-normal" subclasses in the Branch et al. (2009) classification scheme, and on the border between normal and "high-velocity" SNe Ia in the Wang et al. (2009a) system. Though it is a ...

  11. Gait phase varies over velocities.

    Liu, Yancheng; Lu, Kun; Yan, Songhua; Sun, Ming; Lester, D Kevin; Zhang, Kuan


    We sought to characterize the percent (PT) of the phases of a gait cycle (GC) as velocity changes to establish norms for pathological gait characteristics with higher resolution technology. Ninety five healthy subjects (49 males and 46 females with age 34.9 ± 11.8 yrs, body weight 64.0 ± 11.7 kg and BMI 23.5 ± 3.6) were enrolled and walked comfortably on a 10-m walkway at self-selected slower, normal, and faster velocities. Walking was recorded with a high speed camera (250 frames per second) and the eight phases of a GC were determined by examination of individual frames for each subject. The correlation coefficients between the mean PT of the phases of the three velocities gaits and PT defined by previous publications were all greater than 0.99. The correlation coefficient between velocity and PT of gait phases is -0.83 for loading response (LR), -0.75 for mid stance (MSt), and -0.84 for pre-swing (PSw). While the PT of the phases of three velocities from this study are highly correlated with PT described by Dr. Jacquenlin Perry decades ago, actual PT of each phase varied amongst these individuals with the largest coefficient variation of 24.31% for IC with slower velocity. From slower to faster walk, the mean PT of MSt diminished from 35.30% to 25.33%. High resolution recording revealed ambiguity of some gait phase definitions, and these data may benefit GC characterization of normal and pathological gait in clinical practice. The study results indicate that one should consider individual variations and walking velocity when evaluating gaits of subjects using standard gait phase classification.

  12. Velocity envelope of vector flow estimation with spatial quadrature

    Kerr, Richard F.; Anderson, Martin E.


    We present the results of two studies investigating the optimal aperture configuration for maximized lateral blood flow velocity estimation using Heterodyned Spatial Quadrature. Our objective was to determine the maximum velocities that can be estimated at Doppler angles of 90 degrees and 60 degrees with a bias of less than 5% for both uniform scatterer motion in a tissue-mimicking phantom and blood-mimicking fluid circulated through a wall-less vessel flow phantom. Constant flow rates ranging from 3.0 to 18.0 ml/sec were applied in the flow phantom, producing expected peak velocities of 15.0 to 89.8 cm/sec under laminar flow conditions. Velocity estimates were obtained at each flow rate using 256 trials, with each trial consisting of an ensemble of 32 vectors. For an f/1 receive geometry with bi-lobed Hamming apodization, all peak flow velocities tested were estimated to within 5% of their expected values for both 90 degree and 60 degree Doppler angles. An f/2 receive geometry featuring bi-lobed Blackman apodization generally provided accurate lateral velocity estimates up to 71.9 cm/sec for a Doppler angle of 90 degrees, and accurate lateral component estimates up to 50.1 cm/sec for a 60 degree Doppler angle. The implications of these findings will be discussed.

  13. Comparing dynamic surface tilt with velocity using an LDV

    Bruce, Robert A.


    If a laser Doppler vibrometer (LDV) probe beam is normally incident on a resonating metal strip with a mirror-finish, the retro-reflected beam has corresponding dynamic deflections. These lateral beam offsets are proportional to the dynamic surface tilt and can be measured along with the LDV velocity using a separating beam-splitter and a two-dimensional position sensitive detector (PSD). On a thin unbound strip resonating with 'pure mode' deformation, these derivative motions, velocity and tilt, are completely complementary. On a thin unbound plate resonating with 'hybrid mode' deformation, velocity and now two orthogonal tilts are nearly complementary. Maximal tilt has zero velocity, and maximum deformation or velocity has zero tilt. Intermediate values range in complementary fashion except near 'cross-nodes' zones. Here both motion types drop to zero at these cross-node locations. Both velocity and tilt signals are compared simultaneously using a special test fixture. This fixture consists of a stainless steel strip supported on its edges in the center, which can be excited by small speakers at the ends. Two comparison/calibration approaches are demonstrated with a pure 3-0 mode. Significant modal details are also demonstrated by analyzing multiple modes from pulsed excitation, and mapping a 3-1 mode-shape using the combined sensing approaches.


    M. Rengel


    Full Text Available The collision of the projectile released from NASA Deep Impact spacecraft on the nucleus of comet 9P/Tempel 1 generated a hot plume. Afterwards ejecta were created, and material moved slowly in a form of a dust cloud, which dissipated during several days after the impact. Here we report a study about the distribution of terminal velocities of the particles ejected by the impact. This is performed by the development and application of an illconditioned inverse problem approach. We model the light-curves as seen by the Narrow Angle Camera (NAC of OSIRIS onboard the ESA spacecraft Rosetta, and we compare them with the OSIRIS observations. Terminal velocities are derived using a maximum likelihood estimator. The dust velocity distribution is well constrained, and peaks at around 220 m s-1, which is in good agreement with published estimates of the expansion velocities of the dust cloud. Measured and modeled velocity of the dust cloud suggests that the impact ejecta were quickly accelerated by the gas in the cometary coma. This analysis provides a more thorough understanding of the properties (velocity and mass of dust of the Deep Impact dust cloud.

  15. Velocity and directionality of the electrohysterographic signal propagation.

    Lasse Lange

    Full Text Available OBJECTIVE: The initiation of treatment for women with threatening preterm labor requires effective distinction between true and false labor. The electrohysterogram (EHG has shown great promise in estimating and classifying uterine activity. However, key issues remain unresolved and no clinically usable method has yet been presented using EHG. Recent studies have focused on the propagation velocity of the EHG signals as a potential discriminator between true and false labor. These studies have estimated the propagation velocity of individual spikes of the EHG signals. We therefore focus on estimating the propagation velocity of the entire EHG burst recorded during a contraction in two dimensions. STUDY DESIGN: EHG measurements were performed on six women in active labor at term, and a total of 35 contractions were used for the estimation of propagation velocity. The measurements were performed using a 16-channel two-dimensional electrode grid. The estimates were calculated with a maximum-likelihood approach. RESULTS: The estimated average propagation velocity was 2.18 (±0.68 cm/s. No single preferred direction of propagation was found. CONCLUSION: The propagation velocities estimated in this study are similar to those reported in other studies but with a smaller intra- and inter-patient variation. Thus a potential tool has been established for further studies on true and false labor contractions.

  16. Intramuscular fiber conduction velocity, isometric force and explosive performance.

    Methenitis, Spyridon; Terzis, Gerasimos; Zaras, Nikolaos; Stasinaki, Angeliki-Nikoletta; Karandreas, Nikolaos


    Conduction of electrical signals along the surface of muscle fibers is acknowledged as an essential neuromuscular component which is linked with muscle force production. However, it remains unclear whether muscle fiber conduction velocity (MFCV) is also linked with explosive performance. The aim of the present study was to investigate the relationship between vastus lateralis MFCV and countermovement jumping performance, the rate of force development and maximum isometric force. Fifteen moderately-trained young females performed countermovement jumps as well as an isometric leg press test in order to determine the rate of force development and maximum isometric force. Vastus lateralis MFCV was measured with intramuscular microelectrodes at rest on a different occasion. Maximum MFCV was significantly correlated with maximum isometric force (r = 0.66, p rate of force development at 100 ms, 150 ms, 200 ms, and 250 ms (r = 0.85, r = 0.89, r = 0.91, r = 0.92, respectively, p rate of force development than with maximum isometric leg press force. Lower, but significant correlations were found between mean MFCV and countermovement jump power (r = 0.65, p rate of force development than with isometric force, perhaps because conduction velocity is higher in the larger and fastest muscle fibers which are recognized to contribute to explosive actions.

  17. Effects of aging on maximal and rapid velocity capacities of the leg extensors.

    Thompson, Brennan J; Conchola, Eric C; Palmer, Ty B; Stock, Matt S


    Declines in muscle strength and power are commonly reported as a consequence of aging; however, few studies have investigated the influence of aging on maximal and rapid velocity characteristics. The objective of this study was to examine the effects of aging on maximal and rapid velocity characteristics of the leg extensor muscles. Twenty-three young (age=25±3yrs) and twenty-one old (72±4yrs) men performed three leg extension maximal voluntary contractions (MVCs) at 240°·s(-1) and at maximum unloaded velocity (Vmax). Vmax was calculated as the highest velocity attained during the unloaded MVC and RVD was the linear slope of the velocity-time curve for the 240deg·s(-1) (RVD240) and maximum unloaded velocity (RVD-Vmax) contractions. The old men exhibited lower (Pmuscle to generate velocity rapidly versus the ability to generate maximal velocity. Such findings highlight the importance of time-dependent velocity measures when assessing the effects of aging on rapid velocity capacities.

  18. Scaling of low-velocity impact for symmetric composite laminates

    Sankar, Bhavani V.


    The equations governing the problem of low-velocity impact of a simply supported rectangular midplane-symmetric laminated plate are nondimensionalized such that the problem is defined in terms of five dimensionless parameters. A parametric study using the Graeco-Latin Factorial Plan is performed. Semi-empirical formulas for maximum impact force, impact duration, and maximum back surface strains are obtained. It is found that some of the simple impact models provide the bounds for the case of impact on a finite extent plate. A one parameter model is derived for impacts of short duration.

  19. Three dimensional reflection velocity analysis based on velocity model scan; Model scan ni yoru sanjigen hanshaha sokudo kaiseki

    Minegishi, M.; Tsuru, T. [Japan National Oil Corp., Tokyo (Japan); Matsuoka, T. [Japan Petroleum Exploration Corp., Tokyo (Japan)


    Introduced herein is a reflection wave velocity analysis method using model scanning as a method for velocity estimation across a section, the estimation being useful in the construction of a velocity structure model in seismic exploration. In this method, a stripping type analysis is carried out, wherein optimum structure parameters are determined for reflection waves one after the other beginning with those from shallower parts. During this process, the velocity structures previously determined for the shallower parts are fixed and only the lowest of the layers undergoing analysis at the time is subjected to model scanning. To consider the bending of ray paths at each velocity boundaries involving shallower parts, the ray path tracing method is utilized for the calculation of the reflection travel time curve for the reflection surface being analyzed. Out of the reflection wave travel time curves calculated using various velocity structure models, one that suits best the actual reflection travel time is detected. The degree of matching between the calculated result and actual result is measured by use of data semblance in a time window provided centering about the calculated reflective wave travel time. The structure parameter is estimated on the basis of conditions for the maximum semblance. 1 ref., 4 figs.

  20. [Iliopsoas muscle syndrome. Functional disorders: shortening, spasm and weakness of a structurally unchanged muscle].

    Grgić, Vjekoslav


    Functional (non-organic) disorders of the iliopsoas muscle (IPM), i.e. the shortening, spasm and weakness of the structurally unchanged IPM, can be manifested as abdominal and/or pelvic pain, pain in areas of the thoracolumbar (ThL) and lumbosacral (LS) spine, sacroiliac (SI) joint, hip, groin and anterior thigh on the side of the affected muscle as well as gait disturbances (iliopsoas muscle syndrome). By clinical examination of the IPM, including the transabdominal palpation, stretch and strength tests, pathological masses, shortening, painful spasm, weakness and tendon tenderness of that muscle can be diagnosed. The IPM is, like other postural muscles, inclined to shortening. The weakness of the IPM can be a consequence of the lesion of the lumbar plexus or femoral nerve that innervate the IPM, as well as a consequence of certain organic diseases of the IPM. Painful stimuli coming from somatic and visceral structures that are innervated from Th12-L4 nerve roots, from which the IPM segmental innervation also originates, can cause a reflex spasm of the IPM. A painful spasm of the IPM caused by disorders of the ThL and LS spine, SI and hip joint, can mimic diseases of the abdominal and pelvic organs. In the differential diagnosis of the IPM painful spasm, organic diseases of that muscle should be considered foremost (abscess, hematoma, tumor, metastase), as they can result in spasm, and the diseases of the abdominal and pelvic organs that can cause an IPM reflex spasm. The IPM functional disorders, which are not rare, are often overlooked during a clinical examination of a patient. Reasons for overlooking these disorders are: 1) a nonspecific and variable clinical picture presenting the IPM functional disorders, 2) the IPM functional disorders are a neglected source of pain, 3) the inaccessibility of the IPM for inspection, 4) the lack of knowledge of the IPM examination techniques and 5) the IPM functional disorders cannot be discovered by radiological

  1. Studies on Frying Quality of Virgin Coconut Oil and Shortening Blends

    Muhammad Nor Omar


    Full Text Available The frying performances of palm solid shortening (PS and virgin coconut oil (VCO blends were evaluated. The fresh chickens were fried in a blended frying medium using an open fryer for 8 hours per day intermittently at 30 min interval for five consecutive days. Three types of oils were used; i.e. palm shortening without blending (PS, a blend of VCO: PS (10:90, and a blend of VCO: PS (20:80. The frying oils were collected periodically and their fatty acid composition (FAC, free fatty acid (FFA content, total polar compound (TPC and total polymer material (TPM were determined. In addition, the fried chicken was subjected to the analyses of oil absorption and sensory evaluation. The results showed that the frying performance of the VCO:PS (20:80 blend was better than VCO:PS (10:90 blend and PS in terms of TPM and TPC contents. The VCO:PS (20:80 gave TPC and TPM values of 17.4 and 1.40% respectively, the blend of VCO:PS (10:90 gave values of TPC and TPM of 18. 7 and 2.20% respectively, whilst PS with TPC of and TPM of 20.5 and 3.02 % respectively. Meanwhile, the oil absorption patterns showed that the fried chicken in VCO: PS (10:90 blend absorbed less oil compared to chickens fried in PS and VCO:PS (20:80 blend. The oil uptake in chickens fried in VCO:PS (10:90 blend was 1.75%, while in PS and VCO:PS (20:80 blend were 2.82 and 2.57 % respectively. In term of sensory evaluation, the addition of virgin coconut oil (VCO to palm based solid shortening (PS showed significant differences (p < 0.05 on crispiness, taste and overall scores on the 1st , 3rd and 5th day of frying. Although there were no significant difference on oiliness on the 1st and 3rd day, there was a significant difference on the 5th day of frying. In conclusion, the addition of a small proportion of VCO in PS would improve the frying performance of oil as well as sensory scores of the fried products.

  2. Shortened telomere length is associated with increased risk of cancer: a meta-analysis.

    Hongxia Ma

    Full Text Available BACKGROUND: Telomeres play a key role in the maintenance of chromosome integrity and stability, and telomere shortening is involved in initiation and progression of malignancies. A series of epidemiological studies have examined the association between shortened telomeres and risk of cancers, but the findings remain conflicting. METHODS: A dataset composed of 11,255 cases and 13,101 controls from 21 publications was included in a meta-analysis to evaluate the association between overall cancer risk or cancer-specific risk and the relative telomere length. Heterogeneity among studies and their publication bias were further assessed by the χ(2-based Q statistic test and Egger's test, respectively. RESULTS: The results showed that shorter telomeres were significantly associated with cancer risk (OR = 1.35, 95% CI = 1.14-1.60, compared with longer telomeres. In the stratified analysis by tumor type, the association remained significant in subgroups of bladder cancer (OR = 1.84, 95% CI = 1.38-2.44, lung cancer (OR = 2.39, 95% CI = 1.18-4.88, smoking-related cancers (OR = 2.25, 95% CI = 1.83-2.78, cancers in the digestive system (OR = 1.69, 95% CI = 1.53-1.87 and the urogenital system (OR = 1.73, 95% CI = 1.12-2.67. Furthermore, the results also indicated that the association between the relative telomere length and overall cancer risk was statistically significant in studies of Caucasian subjects, Asian subjects, retrospective designs, hospital-based controls and smaller sample sizes. Funnel plot and Egger's test suggested that there was no publication bias in the current meta-analysis (P = 0.532. CONCLUSIONS: The results of this meta-analysis suggest that the presence of shortened telomeres may be a marker for susceptibility to human cancer, but single larger, well-design prospective studies are warranted to confirm these findings.

  3. A dual method for maximum entropy restoration

    Smith, C. B.


    A simple iterative dual algorithm for maximum entropy image restoration is presented. The dual algorithm involves fewer parameters than conventional minimization in the image space. Minicomputer test results for Fourier synthesis with inadequate phantom data are given.

  4. Maximum Throughput in Multiple-Antenna Systems

    Zamani, Mahdi


    The point-to-point multiple-antenna channel is investigated in uncorrelated block fading environment with Rayleigh distribution. The maximum throughput and maximum expected-rate of this channel are derived under the assumption that the transmitter is oblivious to the channel state information (CSI), however, the receiver has perfect CSI. First, we prove that in multiple-input single-output (MISO) channels, the optimum transmission strategy maximizing the throughput is to use all available antennas and perform equal power allocation with uncorrelated signals. Furthermore, to increase the expected-rate, multi-layer coding is applied. Analogously, we establish that sending uncorrelated signals and performing equal power allocation across all available antennas at each layer is optimum. A closed form expression for the maximum continuous-layer expected-rate of MISO channels is also obtained. Moreover, we investigate multiple-input multiple-output (MIMO) channels, and formulate the maximum throughput in the asympt...

  5. Photoemission spectromicroscopy with MAXIMUM at Wisconsin

    Ng, W.; Ray-Chaudhuri, A.K.; Cole, R.K.; Wallace, J.; Crossley, S.; Crossley, D.; Chen, G.; Green, M.; Guo, J.; Hansen, R.W.C.; Cerrina, F.; Margaritondo, G. (Dept. of Electrical Engineering, Dept. of Physics and Synchrotron Radiation Center, Univ. of Wisconsin, Madison (USA)); Underwood, J.H.; Korthright, J.; Perera, R.C.C. (Center for X-ray Optics, Accelerator and Fusion Research Div., Lawrence Berkeley Lab., CA (USA))


    We describe the development of the scanning photoemission spectromicroscope MAXIMUM at the Wisoncsin Synchrotron Radiation Center, which uses radiation from a 30-period undulator. The article includes a discussion of the first tests after the initial commissioning. (orig.).

  6. Maximum-likelihood method in quantum estimation

    Paris, M G A; Sacchi, M F


    The maximum-likelihood method for quantum estimation is reviewed and applied to the reconstruction of density matrix of spin and radiation as well as to the determination of several parameters of interest in quantum optics.

  7. The maximum entropy technique. System's statistical description

    Belashev, B Z


    The maximum entropy technique (MENT) is applied for searching the distribution functions of physical values. MENT takes into consideration the demand of maximum entropy, the characteristics of the system and the connection conditions, naturally. It is allowed to apply MENT for statistical description of closed and open systems. The examples in which MENT had been used for the description of the equilibrium and nonequilibrium states and the states far from the thermodynamical equilibrium are considered

  8. 19 CFR 114.23 - Maximum period.


    ... 19 Customs Duties 1 2010-04-01 2010-04-01 false Maximum period. 114.23 Section 114.23 Customs... CARNETS Processing of Carnets § 114.23 Maximum period. (a) A.T.A. carnet. No A.T.A. carnet with a period of validity exceeding 1 year from date of issue shall be accepted. This period of validity cannot be...

  9. Maximum-Likelihood Detection Of Noncoherent CPM

    Divsalar, Dariush; Simon, Marvin K.


    Simplified detectors proposed for use in maximum-likelihood-sequence detection of symbols in alphabet of size M transmitted by uncoded, full-response continuous phase modulation over radio channel with additive white Gaussian noise. Structures of receivers derived from particular interpretation of maximum-likelihood metrics. Receivers include front ends, structures of which depends only on M, analogous to those in receivers of coherent CPM. Parts of receivers following front ends have structures, complexity of which would depend on N.

  10. Intramuscular fiber conduction velocity, isometric force and explosive performance

    Methenitis Spyridon; Terzis Gerasimos; Zaras Nikolaos; Stasinaki Angeliki-Nikoletta; Karandreas Nikolaos


    Conduction of electrical signals along the surface of muscle fibers is acknowledged as an essential neuromuscular component which is linked with muscle force production. However, it remains unclear whether muscle fiber conduction velocity (MFCV) is also linked with explosive performance. The aim of the present study was to investigate the relationship between vastus lateralis MFCV and countermovement jumping performance, the rate of force development and maximum isometric force. Fifteen moder...

  11. Intramuscular fiber conduction velocity, isometric force and explosive performance

    Methenitis, Spyridon; Terzis, Gerasimos; Zaras, Nikolaos; Stasinaki, Angeliki-Nikoletta; Karandreas, Nikolaos


    Abstract Conduction of electrical signals along the surface of muscle fibers is acknowledged as an essential neuromuscular component which is linked with muscle force production. However, it remains unclear whether muscle fiber conduction velocity (MFCV) is also linked with explosive performance. The aim of the present study was to investigate the relationship between vastus lateralis MFCV and countermovement jumping performance, the rate of force development and maximum isometric force. Fift...

  12. Velocity requirements for causality violation

    Modanese, Giovanni


    It is known that the hypothetical existence of superluminal signals would imply the logical possibility of active causal violation: an observer in relative motion with respect to a primary source could in principle emit secondary superluminal signals (triggered by the primary ones) which go back in time and deactivate the primary source before the initial emission. This is a direct consequence of the structure of the Lorentz transformations, sometimes called "Regge-Tolman paradox". It is straightforward to find a formula for the velocity of the moving observer required to produce the causality violation. When applied to some recent claims of slight superluminal propagation, this formula yields a required velocity very close to the speed of light; this raises some doubts about the real physical observability of such violations. We re-compute this velocity requirement introducing a realistic delay between the reception of the primary signal and the emission of the secondary. It turns out that for -any- delay it...

  13. Signal velocity in oscillator arrays

    Cantos, C. E.; Veerman, J. J. P.; Hammond, D. K.


    We investigate a system of coupled oscillators on the circle, which arises from a simple model for behavior of large numbers of autonomous vehicles where the acceleration of each vehicle depends on the relative positions and velocities between itself and a set of local neighbors. After describing necessary and sufficient conditions for asymptotic stability, we derive expressions for the phase velocity of propagation of disturbances in velocity through this system. We show that the high frequencies exhibit damping, which implies existence of well-defined signal velocitiesc+ > 0 and c- < 0 such that low frequency disturbances travel through the flock as f+(x - c+t) in the direction of increasing agent numbers and f-(x - c-t) in the other.

  14. Estimation of velocity vectors in synthetic aperture ultrasound imaging

    Jensen, Jørgen Arendt; Oddershede, Niels


    A method for determining both velocity magnitude and angle in a synthetic aperture ultrasound system is described. The approach uses directional beamforming along the flow direction and cross-correlation to determine velocity magnitude. The angle of the flow is determined from the maximum...... of the visually determined flow angle. The standard deviation of these estimates was below 2.7 deg. Full color flow maps from different parts of the cardiac cycle are presented, including vector arrows indicating both estimated flow direction and velocity magnitude....... normalized correlation calculated as a function of angle. This assumes the flow direction is within the imaging plane. Simulations of the angle estimation method show both biases and standard deviations of the flow angle estimates below 3 deg for flow angles from 20 deg to 90 deg (transverse flow...

  15. Velocity and rotation measurements in acoustically levitated droplets

    Saha, Abhishek [University of Central Florida, Orlando, FL 32816 (United States); Basu, Saptarshi [Indian Institute of Science, Bangalore 560012 (India); Kumar, Ranganathan, E-mail: [University of Central Florida, Orlando, FL 32816 (United States)


    The velocity scale inside an acoustically levitated droplet depends on the levitator and liquid properties. Using Particle Imaging Velocimetry (PIV), detailed velocity measurements have been made in a levitated droplet of different diameters and viscosity. The maximum velocity and rotation are normalized using frequency and amplitude of acoustic levitator, and droplet viscosity. The non-dimensional data are fitted for micrometer- and millimeter-sized droplets levitated in different levitators for different viscosity fluids. It is also shown that the rotational speed of nanosilica droplets at an advanced stage of vaporization compares well with that predicted by exponentially fitted parameters. -- Highlights: ► Demonstrates the importance of rotation in a levitated droplet that leads to controlled morphology. ► Provides detailed measurements of Particle Image Velocimetry inside levitated droplets. ► Shows variation of vortex strength with the droplet diameter and viscosity of the liquid.

  16. The effect of dark matter velocity profile on directional detection of dark matter

    Laha, Ranjan


    Directional detection is an important way to detect dark matter. An input to these experiments is the dark matter velocity distribution. Recent hydrodynamical simulations have shown that the dark matter velocity distribution differs substantially from the Standard Halo Model. We study the impact of some of these updated velocity distribution in dark matter directional detection experiments. We calculate the ratio of events required to confirm the forward-backward asymmetry and the existence of the ring of maximum recoil rate using different dark matter velocity distributions for $^{19}$F and Xe targets. We show that with the use of updated dark matter velocity profiles, the forward-backward asymmetry and the ring of maximum recoil rate can be confirmed using a factor of $\\sim$2 -- 3 less events when compared to that using the Standard Halo Model.


    Pandya A M


    Full Text Available Sexual identification from the skeletal parts has medico legal and anthropological importance. Present study aims to obtain values of maximum femoral length and to evaluate its possible usefulness in determining correct sexual identification. Study sample consisted of 184 dry, normal, adult, human femora (136 male & 48 female from skeletal collections of Anatomy department, M. P. Shah Medical College, Jamnagar, Gujarat. Maximum length of femur was considered as maximum vertical distance between upper end of head of femur and the lowest point on femoral condyle, measured with the osteometric board. Mean Values obtained were, 451.81 and 417.48 for right male and female, and 453.35 and 420.44 for left male and female respectively. Higher value in male was statistically highly significant (P< 0.001 on both sides. Demarking point (D.P. analysis of the data showed that right femora with maximum length more than 476.70 were definitely male and less than 379.99 were definitely female; while for left bones, femora with maximum length more than 484.49 were definitely male and less than 385.73 were definitely female. Maximum length identified 13.43% of right male femora, 4.35% of right female femora, 7.25% of left male femora and 8% of left female femora. [National J of Med Res 2011; 1(2.000: 67-70

  18. On Global Magnetic ``Monopoly'' Near Solar Cycle Maximums

    Kryvodubskyj, V.

    During last maximums of the solar activity the both poles of the polar magnetic field had the same polarity. Since in the turbulent α Ω -dynamo model the excitation thresholds of the periodic dipole and quadrupole modes of the poloidal madnetic field (PMF) are rather close [Parker E. N.: 1971, Ap.J. V. 164, p. 491] then it is possible that the quadrupole mode may be excited due to variations of physical parameters in a some regions of the solar convection zone (SCZ). The pattern of the excited modes (dipole, quadrupole, octupole, etc.) is determined by the values of wave number of the Parker's dynamo-wave. We calculated these values for the SCZ model by Stix (1989) [Stix M.: 1989, The Sun. Berlin, p. 200] in the vicinity of solar tachocline (a region of strong shear of angular velocity at the base of the SCZ) with using our estimation of the helical turbulence parameter [Krivodubskij V. N.: 1998, Astron. Reports V. 42, No 1, p. 122] and values of the radial gradient of the angular velocity obtained from the newer helioseismic measurements (during rising phase of 23th solar cycle: 1995-1999) [Howe R.,Christensen-Dalsgaard J., Hill F. et al.: 2000, Science. V. 287, p. 2456]. It is found out that at low latitudes dynamo mechanism produces rather the dipole (wave number ≈ -7), the main antisymmetric, relatively to equatorial plane, mode of the PMF; while at the latitudes higher than 50o the conditions are more favourable for exciting of the quadrupole (wave number ≈ +8), the lowest symmetric mode. Arised north-south magnetic structure asymmetry gives an opportunity to explain the space magnetic anomaly of the PMF (``monopoly'') observed near solar cycle maximums.

  19. Planar Velocity Distribution of Viscous Debris Flow at Jiangjia Ravine, Yunnan, China: A Field Measurement Using Two Radar Velocimeters

    FU Xudong; WANG Guangqian; KANG Zhicheng; FEI Xiangjun


    Characteristics of planar velocity distribution of viscous debris flow were analyzed using the measured data at Jiangjia Ravine, Yunnan, China. The velocity data were measured through using two radar velocimeters. The cross-sectional mean velocities were calculated and used to examine Kang et al's (2004) relationship, which was established for converting the flow velocity at river centerline measured by a radar velocimeter into the mean velocity based on the stop-watch method. The velocity coefficient, K, defined by the ratio of the mean velocity to the maximum velocity, ranges from 0.2 to 0.6. Kang et al's (2004) relationship was found being inapplicable to flows with K smaller than 0.43. This paper contributes to show the complexity of the planar velocity distribution of viscous debris flows and the applicability of Kang et al's relationship.

  20. Missing shortening in the thick-skinned retroarc thrust belt of the central Andes, northwestern Argentina, ~25°S

    Pearson, D. M.; Kapp, P. A.; Decelles, P. G.; Reiners, P. W.


    A very large discrepancy exists among estimated retroarc shortening magnitudes in the thin-skinned thrust belt of Bolivia and the thick-skinned thrust belt of northwestern Argentina. Fieldwork and structural analysis from this study at ~25°S latitude in northwestern Argentina confirm the presence of a mainly west verging, thick-skinned style of shortening in the region which, taken together with thermochronological data ((U-Th)/He in zircon and apatite and published apatite fission track results), imply up to 10 km of rapid, Miocene exhumation. Although these results suggest that significant exhumation occurred in the region, displacements on mapped, discrete faults are insufficient in magnitude (by ~15-20%) to generate the observed ~58 km thick crust (Yuan et al., 2002). We suggest that additional, unrecognized shortening or crustal addition is required in the region to explain the thick crust and occurred by 1) crustal flow from neighboring regions of thickened crust; 2) passive roof thrusting whereby major, likely mid-crustal shortening was fed to higher structural levels; 3) tectonic underplating of trench or forearc rocks; and/or 4) significant penetrative strain not accommodated by through going faults. We do not discard other mechanisms of crustal thickening and/or addition in the region, but magnitudes of upper crustal shortening required by excess area calculations are best explained by penetrative deformation within rheologically weak metaturbidites of the Neoproterozoic to Cambrian Puncoviscana Formation. Although penetrative strain was generally not considered in cross section restorations in the retroarc of Bolivia, a relative lack of these rheologically weak rocks there probably precludes penetrative deformation as a significant mode of deformation and may partially reconcile the discrepancy in along-strike shortening magnitudes. Significant shortening has been accommodated by penetrative strain in other orogens worldwide, including western North

  1. Effect of positional changes of anatomic structures on upper airway dilating muscle shortening during electro- and chemostimulation.

    Oliven, A; Odeh, M


    Positional changes of anatomic structures surrounding the upper airway are known to affect pharyngeal mechanics and collapsibility. We hypothesized that these alterations also affect the ability of the upper airway dilator muscles to enlarge the pharynx by altering their ability to shorten when activated. Using sonomicrometry, we evaluated in seven anesthetized dogs the effects of changes in tracheal and head position on the length of the genioglossus (GG) and the geniohyoid (GH) and the effects of these positional changes on the magnitude of shortening of the two muscles in response to electro- (ES) and chemostimulation (CS). Caudal traction of the trachea lengthened the GG and GH in all dogs, whereas cranial displacement of the trachea and flexion of the head to a vertical position shortened the muscles. Compared with the magnitude of ES-induced shortening in the neutral position, ES-induced shortening of the GG was 144.7 +/- 14.6, 49.3 +/- 4.3, and 33.5 +/- 11.6% during caudal and cranial displacement of the trachea and during head flexion, respectively. Similar effects of the positional changes were found for the GH, as well as for both muscles during respiratory stimulation with P(CO2) of 90 Torr at the end of CO(2) rebreathing, although inspiratory muscle shortening during CS reached only one-quarter to one-third of the magnitude observed during ES. We conclude that positional alterations of anatomic structures in the neck have a dramatic effect on the magnitude of shortening of the activated GG and GH, which may reduce substantially their ability to protect pharyngeal patency.

  2. Angle independent velocity spectrum determination


    An ultrasound imaging system (100) includes a transducer array (102) that emits an ultrasound beam and produces at least one transverse pulse-echo field that oscillates in a direction transverse to the emitted ultrasound beam and that receive echoes produced in response thereto and a spectral vel...... velocity estimator (110) that determines a velocity spectrum for flowing structure, which flows at an angle of 90 degrees and flows at angles less than 90 degrees with respect to the emitted ultrasound beam, based on the received echoes....

  3. Velocity of lordosis angle during spinal flexion and extension.

    Tobias Consmüller

    Full Text Available The importance of functional parameters for evaluating the severity of low back pain is gaining clinical recognition, with evidence suggesting that the angular velocity of lordosis is critical for identification of musculoskeletal deficits. However, there is a lack of data regarding the range of functional kinematics (RoKs, particularly which include the changing shape and curvature of the spine. We address this deficit by characterising the angular velocity of lordosis throughout the thoracolumbar spine according to age and gender. The velocity of lumbar back shape changes was measured using Epionics SPINE during maximum flexion and extension activities in 429 asymptomatic volunteers. The difference between maximum positive and negative velocities represented the RoKs. The mean RoKs for flexion decreased with age; 114°/s (20-35 years, 100°/s (36-50 years and 83°/s (51-75 years. For extension, the corresponding mean RoKs were 73°/s, 57°/s and 47°/s. ANCOVA analyses revealed that age and gender had the largest influence on the RoKs (p<0.05. The Epionics SPINE system allows the rapid assessment of functional kinematics in the lumbar spine. The results of this study now serve as normative data for comparison to patients with spinal pathology or after surgical treatment.

  4. Prediction of peak forces for a shortening smooth muscle tissue subjected to vibration.

    Pidaparti, Ramana M; Dhanaraj, Nandhini; Meiss, Richard A


    The objective of the present study is to investigate the peak forces for a tracheal smooth muscle tissue subjected to an applied longitudinal vibration following isotonic shortening. A non-linear finite element analysis was carried out to simulate the vibratory response under experimental conditions that corresponds to forced length oscillations at 33 Hz for 1 second. The stiffness change and hysteresis estimated from the experimental data was used in the analysis. The finite element results of peak forces are compared to the experimental data obtained. The comparison of results indicate that the approach and the vibratory response obtained may be useful for describing the cross-bridge de-attachments within the cells as well as connective tissue connections characteristic of tracheal smooth muscle tissue.

  5. Characterization of graininess formed in all beef tallow-based shortening.

    Meng, Zong; Liu, Yuan-Fa; Jin, Qing-Zhe; Huang, Jian-Hua; Song, Zhi-Hua; Wang, Feng-Yan; Wang, Xing-Guo


    A batch of all beef tallow (BT)-based model shortening (divided into six rectangular block samples) was stored under temperature fluctuation cycles of 5-20 °C until granular crystals were observed. The lipid composition, thermal properties, and polymorphism of the granular crystals and their surrounding materials were evaluated. Furthermore, the isothermal crystallization behavior of two parts noted above was also examined by pulsed nuclear magnetic resonance (pNMR), rheology, and polarized light microscopy (PLM). The changes of nanostructure including the aggregation of high-melting triacylglycerols (TAGs) and transformation into the most stable β polymorph occurred in granular crystals compared with surrounding materials. Concomitantly, a slower crystallization rate with a simultaneous increase in crystal growth led to the formation of large crystals and further aggregated to larger granular crystals when the size ultimately exceeded the sensory threshold.

  6. Shortening trinucleotide repeats using highly specific endonucleases: a possible approach to gene therapy?

    Richard, Guy-Franck


    Trinucleotide repeat expansions are involved in more than two dozen neurological and developmental disorders. Conventional therapeutic approaches aimed at regulating the expression level of affected genes, which rely on drugs, oligonucleotides, and/or transgenes, have met with only limited success so far. An alternative approach is to shorten repeats to non-pathological lengths using highly specific nucleases. Here, I review early experiments using meganucleases, zinc-finger nucleases (ZFN), and transcription-activator like effector nucleases (TALENs) to contract trinucleotide repeats, and discuss the possibility of using CRISPR-Cas nucleases to the same end. Although this is a nascent field, I explore the possibility of designing nucleases and effectively delivering them in the context of gene therapy.

  7. Effect of shortening kraft pulping integrated with extended oxygen delignification on biorefinery process performance of eucalyptus.

    Li, Jing; Zhang, Chunyun; Hu, Huichao; Chai, Xin-Sheng


    The aim of this work was to study the impact of shortening kraft pulping (KP) process integrated with extended oxygen delignification (OD) on the biorefinery process performance of eucalyptus. Data showed that using kraft pulps with high kappa number could improve the delignification efficiency of OD, reduce hexenuronic acid formation in kraft pulps. Pulp viscosity for a target kappa number of ∼10 was comparable to that obtained from conventional KP and OD process. The energy and alkali consumption in the integrated biorefinery process could be optimized when using a KP pulp with kappa number of ∼27. The process could minimize the overall methanol formation, but greater amounts of carbonate and oxalate were formed. The information from this study will be helpful to the future implementation of short-time KP integrated with extended OD process in actual pulp mill applications for biorefinery, aiming at further improvement in the biorefinery effectiveness of hardwood. Copyright © 2015 Elsevier Ltd. All rights reserved.

  8. Age-dependent Muscle Adaptation after Chronic Stretch-shortening Contractions in Rats.

    Rader, Erik P; Layner, KaylaN; Triscuit, Alyssa M; Chetlin, Robert D; Ensey, James; Baker, Brent A


    Age-related differences in contraction-induced adaptation have been well characterized especially for young and old rodent models but much less so at intermediate ages. Therefore, additional research is warranted to determine to what extent alterations in adaptation are due to maturation versus aging per se. The purpose of our study was to evaluate muscles of Fisher 344XBrown Norway rats of various ages following one month of exposure to stretch-shortening contractions (SSCs). With exposure, muscles mass increased by ~10% for 27 and 30 month old rats vs. ~20% for 3 and 6 month old rats (P muscle performance in general beginning at late adulthood. Such findings motivate careful investigation to determine appropriate SSC exposures at all stages of life.

  9. The Paley ulnarization of the carpus with ulnar shortening osteotomy for treatment of radial club hand

    Paley Dror


    Full Text Available Recurrent deformity from centralization and radialization led to the development in 1999 of a new technique by the author called ulnarization. This method is performed through a volar approach in a vascular and physeal sparing fashion. It biomechanically balances the muscle forces on the wrist by dorsally transferring the flexor carpi ulnaris (FCU from a deforming to a corrective force. The previous problems of a prominent bump from the ulnar head and ulnar deviation instability were solved by acutely shortening the diaphysis and by temporarily fixing the station of the carpus to the ulnar head at the level of the scaphoid. This is the first report of this modified Paley ulnarization method, which the author considers a significant improvement over his original procedure.

  10. The Paley ulnarization of the carpus with ulnar shortening osteotomy for treatment of radial club hand

    Paley, Dror


    Recurrent deformity from centralization and radialization led to the development in 1999 of a new technique by the author called ulnarization. This method is performed through a volar approach in a vascular and physeal sparing fashion. It biomechanically balances the muscle forces on the wrist by dorsally transferring the flexor carpi ulnaris (FCU) from a deforming to a corrective force. The previous problems of a prominent bump from the ulnar head and ulnar deviation instability were solved by acutely shortening the diaphysis and by temporarily fixing the station of the carpus to the ulnar head at the level of the scaphoid. This is the first report of this modified Paley ulnarization method, which the author considers a significant improvement over his original procedure. PMID:28120747

  11. Semi-automated detection of fractional shortening in zebrafish embryo heart videos

    Nasrat Sara


    Full Text Available Quantifying cardiac functions in model organisms like embryonic zebrafish is of high importance in small molecule screens for new therapeutic compounds. One relevant cardiac parameter is the fractional shortening (FS. A method for semi-automatic quantification of FS in video recordings of zebrafish embryo hearts is presented. The software provides automated visual information about the end-systolic and end-diastolic stages of the heart by displaying corresponding colored lines into a Motion-mode display. After manually marking the ventricle diameters in frames of end-systolic and end-diastolic stages, the FS is calculated. The software was evaluated by comparing the results of the determination of FS with results obtained from another established method. Correlations of 0.96 < r < 0.99 between the two methods were found indicating that the new software provides comparable results for the determination of the FS.

  12. Present-day shortening in Southern Haiti from GPS measurements and implications for seismic hazard

    Symithe, Steeve; Calais, Eric


    The ~ 3 M inhabitant capital region of Haiti, severely affected by the devastating January 12, 2010, M7.0 earthquake, continues to expand at a fast rate. Accurate characterization of regional earthquake sources is key to inform urban development and construction practices through improved regional seismic hazard estimates. Here we use a recently updated Global Positioning System (GPS) data set to show that seismogenic strain accumulation in southern Haiti involves an overlooked component of shortening on a south-dipping reverse fault along the southern edge of the Cul-de-Sac basin, in addition to the well-known component of left-lateral strike-slip motion. This tectonic model implies that ground shaking may be twice that expected if the major fault was purely strike-slip, as assumed in the current seismic hazard map for the region.

  13. Estimation of the shortening rate since late Pleistocene in the Aksu area on the southern flank of the Tianshan, China

    WANG; Xin


    [1]Molnar, P., Tapponnier, P., Cenozoic tectonics of Asia: Effects on a continental collision, Science, 1975, 189: 419-426.[2]Molnar, P., Deng Qidong, Faulting associated with large earthquakes and the average rate of deformation in central and eastern Asia, J. Geophys. Res., 1984, 89: 6203-6227.[3]Hendrix, M. S., Dumitru, T. A., Graham, S. A., Late Oligocene-early Miocene unroofing in the Chinese Tianshan: An early effect of the India-Asia collision, Geology, 1994, 22: 487-490.[4]Sobel, R. E., Dumitru, T. A., Thrusting and exhumation around the margins of the western Tarim Basin during the India-Asia collision, J. Geophys. Res., 1997, 102: 5043-5063.[5]Ghose, S., Hamburger, M. W., Virieux, J., Three-dimentional velocity structure and earthquake locations beneath the northern Tianshan of Kyrgyzstan, central Asia, J. Geophys. Res., 1998, 103: 2725-2748.[6]Ghose, S., Hamburger, M. W., Ammon, C. J., Source parameters of moderate-sized earthquakes in the Tianshan, central Asia from regional moment tensor inversion, Geophys. Res. lett., 1998, 25: 3181-3184.[7]Abdrakhmatov, K. Ye, Aldazhanov, S. A., Hager, B. H. et al., Relatively recent construction of the Tianshan inferred from GPS measurements of present-day curstal deformation rates, Nature, 1996, 384: 450-452.[8]Wang Qi, Ding Guoyu, Qiao Xuejun et al., Present-day Tianshan's quick shortening and the south-north block's relative movement, Chinese Science Bulletin (in Chinese), 2000, 45(14): 1543-1547.[9]Zhu Wenyao, Wang Xiaoya, Chen Yuyi et al., Crustal motion of Chinese mainland monitored by GPS, Science in China, Ser. D, 2000, 43(2): 394-400.[10]Avouac, J. P., Tapponnier, P., Bai, M. et al., Active thrusting and folding along the northern Tianshan and late cenozoic rotation of the Tarim relative to Dzungaria and Kazakhstan, J. Geopgys. Res., 1993, 98: 6755-6804.[11]Burtman, V. S.,Skobelev, S. F., Molnar, P., Late cenozoic slip on the Talas-Ferghana fault, the Tianshan

  14. HIV Infection Is Associated with Shortened Telomere Length in Ugandans with Suspected Tuberculosis

    Auld, Elizabeth; Lin, Jue; Chang, Emily; Byanyima, Patrick; Ayakaka, Irene; Musisi, Emmanuel; Worodria, William; Davis, J. Lucian; Segal, Mark; Blackburn, Elizabeth; Huang, Laurence


    Introduction HIV infection is a risk factor for opportunistic pneumonias such as tuberculosis (TB) and for age-associated health complications. Short telomeres, markers of biological aging, are also associated with an increased risk of age-associated diseases and mortality. Our goals were to use a single cohort of HIV-infected and HIV-uninfected individuals hospitalized with pneumonia to assess whether shortened telomere length was associated with HIV infection, TB diagnosis, and 2-month mortality. Methods This was a sub-study of the IHOP Study, a prospective observational study. Participants consisted of 184 adults admitted to Mulago Hospital in Kampala, Uganda who underwent evaluation for suspected TB and were followed for 2 months. Standardized questionnaires were administered to collect demographic and clinical data. PBMCs were isolated and analyzed using quantitative PCR to determine telomere length. The association between HIV infection, demographic and clinical characteristics, and telomere length was assessed, as were the associations between telomere length, TB diagnosis and 2-month mortality. Variables with a P≤0.2 in bivariate analysis were included in multivariate models. Results No significant demographic or clinical differences were observed between the HIV-infected and HIV-uninfected subjects. Older age (Ptelomere length in bivariate analysis. In multivariate analysis adjusting for these five variables, HIV-positive participants had significantly shorter telomeres than HIV-negative participants (β = -0.0621, 95% CI -0.113 to -0.011, P = 0.02). Shortened telomeres were not associated with TB or short-term mortality. Conclusions The association between HIV infection and shorter telomeres suggests that HIV may play a role in cellular senescence and biological aging and that shorter telomeres may be involved in age-associated health complications seen in this population. The findings indicate a need to further research the impact of HIV on aging. PMID

  15. Ankle morphology amplifies calcaneus movement relative to triceps surae muscle shortening.

    Csapo, R; Hodgson, J; Kinugasa, R; Edgerton, V R; Sinha, S


    The present study investigated the mechanical role of the dorsoventral curvature of the Achilles tendon in the conversion of the shortening of the plantarflexor muscles into ankle joint rotation. Dynamic, sagittal-plane magnetic resonance spin-tagged images of the ankle joint were acquired in six healthy subjects during both passive and active plantarflexion movements driven by a magnetic resonance compatible servomotor-controlled foot-pedal device. Several points on these images were tracked to determine the 1) path and deformation of the Achilles tendon, 2) ankle's center of rotation, and 3) tendon moment arms. The degree of mechanical amplification of joint movement was calculated as the ratio of the displacements of the calcaneus and myotendinous junction. In plantarflexion, significant deflection of the Achilles tendon was evident in both the passive (165.7 ± 7.4°; 180° representing a straight tendon) and active trials (166.9 ± 8.8°). This bend in the dorsoventral direction acts to move the Achilles tendon closer to the ankle's center of rotation, resulting in an ∼5% reduction of moment arm length. Over the entire range of movement, the overall displacement of the calcaneus exceeded the displacement of the myotendinous junction by ∼37%, with the mechanical gains being smaller in dorsi- and larger in plantarflexed joint positions. This is the first study to assess noninvasively and in vivo using MRI the curvature of the Achilles tendon during both passive and active plantarflexion movements. The dorsoventral tendon curvature amplifies the shortening of the plantarflexor muscles, resulting in a greater displacement of the tendon's insertion into the calcaneus compared with its origin.

  16. Grafted vertebral fracture after implant removal in a patient with spine-shortening vertebral osteotomy.

    Nakashima, Hiroaki; Yukawa, Yasutsugu; Ito, Keigo; Machino, Masaaki; Kanbara, Shunsuke; Morita, Daigo; Imagama, Shiro; Ishiguro, Naoki; Kato, Fumihiko


    We experienced the rare complication of a vertebral fracture that was caused by implant removal after bony fusion had been achieved in a patient who underwent spine-shortening osteotomy (SSO) for tethered cord syndrome (TCS). We propose that the removal of the implant used for SSO should be contraindicated. The patient (a 27-year-old female) presented to our institution with a history of progressive severe lower back pain, gait disturbance, and urinary incontinence. As an infant, she had undergone surgery for spina bifida with lipoma. Magnetic resonance imaging of the spine revealed tethering of the spinal cord to a lipoma. We performed SSO at the level of the L1 vertebra level. After spine shortening and fixation using a posterior approach, the L1 vertebral body was completely removed anteriorly and replaced with a left iliac bone graft. The patient's symptoms improved after surgery. After bony fusion was achieved after surgery, we decided to remove the spinal implant after we explained the advantages and disadvantages of the procedure to the patient. We performed implant removal surgery safely 2 years later; however, the patient complained of severe lower back pain 10 days after the surgery without any history of trauma. Reconstruction computed tomography showed fracture of the grafted vertebra. We performed a repeat posterior fixation, which relieved the lower back pain; she has experienced no complications in the subsequent 5 years. In summary, we report a case of a rare complication of the fracture of a grafted vertebra after removal of an implant used in SSO for TCS. Spinal stability could not be maintained without the spinal posterior implant after SSO. Postoperative fracture after spinal implant removal is rare but possible, and patients must be informed of this potential risk.

  17. Shortening Infusion Time for High-Dose Methotrexate Alters Antileukemic Effects: A Randomized Prospective Clinical Trial

    Mikkelsen, Torben S.; Sparreboom, Alex; Cheng, Cheng; Zhou, Yinmei; Boyett, James M.; Raimondi, Susana C.; Panetta, John C.; Bowman, W. Paul; Sandlund, John T.; Pui, Ching-Hon; Relling, Mary V.; Evans, William E.


    Purpose To determine whether shortening the infusion duration of high-dose methotrexate (HDMTX; 1 g/m2) affects the in vivo accumulation of active methotrexate polyglutamates (MTXPG1-7) in leukemia cells and whether this differs among major acute lymphoblastic leukemia (ALL) subtypes. Methods From June 2000 through October 2007, 356 children with ALL were randomly assigned to receive initial single-agent treatment with HDMTX (1 g/m2) as either a 24-hour infusion or a 4-hour infusion at two pediatric hospitals in the United States. The primary outcome measures were the accumulation of MTXPG1-7 in leukemia cells and the antileukemic effects (eg, inhibition of de novo purine synthesis in bone marrow ALL cells, and decrease in circulating ALL cells). Results The 24-hour infusion resulted in significantly higher amounts of MTXPG1-7 in bone marrow leukemia cells (median: 1,695 v 1,150 pmol/109 cells, P = .0059), and better antileukemic effects. The 24-hour infusion had the greatest effect on MTXPG1-7 accumulation in hyperdiploid ALL (median: 3,919 v 2,417 pmol/109 cells, P = .0038); T-cell ALL exhibited smaller differences in MTXPG1-7 but greater antileukemic effects with the longer infusion (median decrease in leukemia cells: 88.4% v 51.8%, P = .0075). In contrast, infusion duration had no significant impact on MTXPG1-7 accumulation or antileukemic effects in ALL with the t(12;21)/(ETV6-RUNX1) chromosomal translocation. Conclusion Shortening the infusion time of HDMTX reduces accumulation of active methotrexate in leukemia cells and decreases antileukemic effects, with differing consequences among major ALL subtypes. PMID:21444869

  18. Feline chronic kidney disease is associated with shortened telomeres and increased cellular senescence.

    Quimby, Jessica M; Maranon, David G; Battaglia, Christine L R; McLeland, Shannon M; Brock, William T; Bailey, Susan M


    Telomeres are protective structures at the ends of chromosomes that have important implications for aging. To address the question of whether telomeres contribute to feline chronic kidney disease (CKD), we evaluated kidney, liver, and skin samples from 12 cats with naturally occurring CKD, 12 young normal cats, and 6 old normal cats. Telomere length was assessed using standard telomere fluorescent in situ hybridization (TEL-FISH) combined with immunohistochemistry (TELI-FISH) to identify proximal (PTEC) and distal tubular epithelial cells (DTEC), whereas senescence-associated β-galactosidase (SABG) staining was used to evaluate senescence. Results revealed statistically significant decreases in the average telomere fluorescence intensity (TFI) of PTEC in CKD cats compared with young and geriatric normal cats, and in the DTEC of CKD cats compared with young normal cats. When histograms of individual TFI were compared, statistically significant decreases in the PTEC and DTEC of CKD cats were observed compared with young and geriatric normal cats. Concomitantly, a statistically significant increase in SABG staining was seen in CKD kidney samples compared with young normal cats. CKD cats tended to have increased SABG staining in the kidney compared with normal geriatric cats, but this did not reach statistical significance. No significant telomere shortening in liver or skin from any group was observed. Real-time quantitative telomeric repeat amplification protocol assessment of renal telomerase activity revealed comparable low levels of telomerase activity in all groups. Our results suggest that shortened telomeres and increased senescence in the kidneys of CKD cats may represent novel targets for interventional therapy.

  19. Anesthetic Sevoflurane Causes Rho-Dependent Filopodial Shortening in Mouse Neurons.

    Jeffrey H Zimering

    Full Text Available Early postnatal anesthesia causes long-lasting learning and memory impairment in rodents, however, evidence for a specific neurotoxic effect on early synaptogenesis has not been demonstrated. Drebrin A is an actin binding protein whose localization in dendritic protrusions serves an important role in dendritic spine morphogenesis, and is a marker for early synaptogenesis. We therefore set out to investigate whether clinically-relevant concentrations of anesthetic sevoflurane, widely- used in infants and children, alters dendritic morphology in cultured fetal day 16 mouse hippocampal neurons. After 7 days in vitro, mouse hippocampal neurons were exposed to four hours of 3% sevoflurane in 95% air/5% CO2 or control condition (95% air/5% CO2. Neurons were fixed in 4% paraformaldehyde and stained with Alexa Fluor555-Phalloidin, and/or rabbit anti-mouse drebrin A/E antibodies which permitted subcellular localization of filamentous (F-actin and/or drebrin immunoreactivity, respectively. Sevoflurane caused acute significant length-shortening in filopodia and thin dendritic spines in days-in-vitro 7 neurons, an effect which was completely rescued by co-incubating neurons with ten micromolar concentrations of the selective Rho kinase inhibitor Y27632. Filopodia and thin spine recovered in length two days after sevoflurane exposure. Yet cluster-type filopodia (a precursor to synaptic filopodia were persistently significantly decreased in number on day-in-vitro 9, in part owing to preferential localization of drebrin immunoreactivity to dendritic shafts versus filopodial stalks. These data suggest that sevoflurane induces F-actin depolymerization leading to acute, reversible length-shortening in dendritic protrusions through a mechanism involving (in part activation of RhoA/Rho kinase signaling and impairs localization of drebrin A to filopodia required for early excitatory synapse formation.

  20. Analysis of combination drug therapy to develop regimens with shortened duration of treatment for tuberculosis.

    Drusano, George L; Neely, Michael; Van Guilder, Michael; Schumitzky, Alan; Brown, David; Fikes, Steven; Peloquin, Charles; Louie, Arnold


    Tuberculosis remains a worldwide problem, particularly with the advent of multi-drug resistance. Shortening therapy duration for Mycobacterium tuberculosis is a major goal, requiring generation of optimal kill rate and resistance-suppression. Combination therapy is required to attain the goal of shorter therapy. Our objective was to identify a method for identifying optimal combination chemotherapy. We developed a mathematical model for attaining this end. This is accomplished by identifying drug effect interaction (synergy, additivity, antagonism) for susceptible organisms and subpopulations resistant to each drug in the combination. We studied the combination of linezolid plus rifampin in our hollow fiber infection model. We generated a fully parametric drug effect interaction mathematical model. The results were subjected to Monte Carlo simulation to extend the findings to a population of patients by accounting for between-patient variability in drug pharmacokinetics. All monotherapy allowed emergence of resistance over the first two weeks of the experiment. In combination, the interaction was additive for each population (susceptible and resistant). For a 600 mg/600 mg daily regimen of linezolid plus rifampin, we demonstrated that >50% of simulated subjects had eradicated the susceptible population by day 27 with the remaining organisms resistant to one or the other drug. Only 4% of patients had complete organism eradication by experiment end. These data strongly suggest that in order to achieve the goal of shortening therapy, the original regimen may need to be changed at one month to a regimen of two completely new agents with resistance mechanisms independent of the initial regimen. This hypothesis which arose from the analysis is immediately testable in a clinical trial.

  1. The Oblique Metaphyseal Shortening Osteotomy of the Distal Ulna: Surgical Technique and Results of Ten Patients.

    Benis, Szabolcs; Goubau, Jean F; Mermuys, Koen; Van Hoonacker, Petrus; Berghs, Bart; Kerckhove, Diederick; Vanmierlo, Bert


    Background Ulnocarpal abutment is a common condition following distal radius fractures. There are different surgical methods of treatment for this pathology: open and arthroscopic wafer procedure or an ulnar shortening osteotomy. We describe an oblique metaphyseal shortening osteotomy of the distal ulna using two cannulated headless compression screws. We report the results of 10 patients treated with this method. Materials and Methods Out of 17 patients, 10 could be reviewed retrospectively for this study. Patient-rated outcomes were measured using the VAS (visual analogue scale) for pain, PRWHE (patient-rated wrist and hand evaluation) survey, and Quick-DASH (disability of arm, shoulder and hand) survey for functional outcomes. At the review we measured the range of motion (ROM) of the wrist (extension and flexion, ulnar and radial deviation, pronation and supination). Grip strength, pronation, and supination strength of the forearm was measured using a calibrated hydraulic dynamometer. ROM and strength of the affected wrist was compared with ROM and strength of the unaffected wrist. Surgical Procedure Oblique long metaphyseal osteotomy of the distal ulna (from proximal-ulnar to distal-radial), fixed with two cannulated headless compression screws. Results The average postoperative VAS score for pain was 23.71 (standard deviation [SD] of 30.41). The average postoperative PRWHE score was 32.55 (SD of 26.28). The average postoperative Quick-DASH score was 28.65 (SD of 27.21). The majority of patients had a comparable ROM and strength between the operated side and the non-operated side. Conclusion This surgical technique has the advantage of reducing the amount of hardware and to decrease the potential hinder caused by it on medium term. Moreover, the incision remains smaller, and the anatomic metaphyseal localization of the osteotomy potentially allows a better and rapid healing.

  2. Discussion on origin of Pn velocity variation in China and adjacent region

    裴顺平; 许忠淮; 汪素云


    Pn velocity lateral variation and anisotropy images were reconstructed by adding about 50 000 travel times from the regional seismic networks to the datum set of near 40 000 travel times from National Seismic Network of China used by WANG, et al. We discussed the relation of Pn velocity variation to Moho depth, Earth's heat flow, distribution of Cenozoic volcanic rock and the result of rock experiment under high pressure and high temperature. The result of quantitative analysis indicates that Pn velocity is positively correlated with the crust thickness and negatively correlated with the Earth's heat flow. Two linear regression equations, one between Pn velocity and crust thickness, and the other between Pn velocity and heat flow, were obtained. The rate of variation of Pn velocity vP with pressure P,()Vp/()P, estimated from the velocity variation with crust thickness()Vp/()His close to the result obtained from the rock experiment under high pressure and high temperature. If the effect of crust thickness on Pn velocity is deducted from the velocity variation, then the low Pn velocity beneath Qinghai-Xizang plateau is more notable. The low Pn velocity regions well agree with the Cenozoic volcanic rock. In the several regions with significant anisotropy, the direction of fast Pn velocity is consistent with the orientation of maximum principal crustal compressive stress, and also with the direction of present-day crustal movement. It indicates that the fast Pn velocity direction may be related to the deformation or flow of top mantle material along the direction of maximum pressure.

  3. Effectiveness comparison of channel-assisted mini-incision and open Achilles shortening for treatment of healed Achilles tendon rupture

    Hong-zhe QI


    Full Text Available Objective To compare the clinical effectiveness between the channel-assisted mini-invasion and open Achilles shortening for treatment of the elongated Achilles tendon following previous rupture. Methods The clinical data of 19 patients admitted from Dec. 2013 to Dec. 2015 and met the inclusion criteria were analyzed retrospectively. Eight patients were treated with shortening operation by channel-assisted minimally invasive repair system, while 11 patients received dissection of Krackow Achilles tendon shortening. There was no significant difference between the two groups in gender, age, injury to operation time, preoperative calf circumference and preoperative AOFAS (American Orthopaedic Foot & Ankle Society score (P>0.05. Results The operation time, incision length and postoperative hospital days were significantly less in min-invasion group than in incision group (P0.05. Conclusion Channel-assisted minimally invasive Achilles tendon shortening operation has not only similar effectiveness to the incision shorting operation for the treatment of elongated Achilles tendon following previous rupture, but also has the advantages of shortening operation time and stay in hospital and avoidance of sural nerve injury. DOI: 10.11855/j.issn.0577-7402.2017.07.12

  4. A Comparative Field Monitoring of Column Shortenings in Tall Buildings Using Wireless and Wired Sensor Network Systems

    Sungho Lee


    Full Text Available A comparative field measurement for column shortening of tall buildings is presented in this study, with a focus on the reliability and stability of a wireless sensor network. A wireless sensor network was used for monitoring the column shortenings of a 58-story building under construction. The wireless sensor network, which was composed of sensor and master nodes, employed the ultra-high-frequency band and CDMA communication methods. To evaluate the reliability and stability of the wireless sensor network system, the column shortenings were also measured using a conventional wired monitoring system. Two vibration wire gauges were installed in each of the selected 7 columns and 3 walls. Measurements for selected columns and walls were collected for 270 days after casting of the concrete. The results measured by the wireless sensor network were compared with the results of the conventional method. The strains and column shortenings measured using both methods showed good agreement for all members. It was verified that the column shortenings of tall buildings could be monitored using the wireless sensor network system with its reliability and stability.

  5. Comparison of EMG during passive stretching and shortening phases of each muscle for the investigation of parkinsonian rigidity.

    Kwon, Yuri; Kim, Ji-Won; Kim, Ji-Sun; Koh, Seong-Beom; Eom, Gwang-Moon; Lim, Tae-Hong


    The aim of this study was to test the hypothesis in the literature that torque resistance of parkinsonian rigidity is the difference between the independent contributions of stretched and shortened muscles. The hypothesis was tested using muscle-specific stretch-shortening (MSSS) EMG ratio in this study. Nineteen patients with idiopathic Parkinson's disease (PD) and 18 healthy subjects (the mean age comparable to that of patients) participated in this study. The EMG activity was measured in the four muscles involved in wrist joint movement, i.e. flexor carpi radialis, flexor carpi ulnaris, extensor carpi radialis and extensor carpi ulnaris. The passive flexion-extension movement with a range of ±30∘ was applied at wrist joint. Root mean squared (RMS) mean was calculated from the envelope of the EMG for each of stretching and shortening phases. MSSS EMG ratio was defined as the ratio of RMS EMG of stretching phase and RMS EMG of shortening phase of a single muscle, and it was calculated for each muscle. MSSS EMG ratios were smaller than one in all muscles. These results indicate that all wrist muscles generate greater mean EMG during shortening than during stretching. Therefore, the torque resistance of parkinsonian rigidity cannot be explained as the simple summation of independent antagonistic torque pair.

  6. Stretch and shortening of skeletal muscles activated along the ascending limb of the force-length relation.

    Rassier, Dilson E; Pun, Clara


    There is a history dependence of skeletal muscle contraction. When muscles are activated and subsequently stretched, they produce a long lasting force enhancement. When muscles are activated and subsequently shortened, they produce a long-lasting force depression. The purposes of the studies shown in this chapter were (1) to evaluate if force enhancement and force depression are present along the ascending limb of the force-length (FL) relation, (2) to evaluate if the history-dependent properties of force production are associated with sarcomere length (SL) non-uniformity, and (3) to determine the effects of cross-bridge (de)activation on force depression. Isolated myofibrils were activated by either Ca²(+) or MgADP and were subjected to consecutive stretches or shortenings along the ascending limb of the FL relation, separated by periods (approximately 5 s) of isometric contraction. Force after stretch was higher than force after shortening when the contractions were produced at similar SLs. The difference in force could not be explained by SL non-uniformity. After shortening, MgADP activation produced forces that were higher than Ca²(+) activation. Since MgADP induces the formation of strongly bound cross-bridges, the result suggests that force depression following shortening is associated with cross-bridge deactivation.

  7. Modulation of soleus H-reflex during shortening and lengthening muscle actions in young and older adults.

    Chen, Yung-Sheng; Zhou, Shi; Cartwright, Colleen


    The H-reflex is dependently modulated during isometric and anisometric muscle actions. However, the manner of the H-reflex modulation during dynamic muscle movements in relation to ageing is less stated in the literature. This study was designed to investigate the effects of ageing on soleus (SOL) H-reflex modulation during dynamic muscle actions. Twenty young (24 ± 4 years of age) and 20 older adults (73 ± 5 years of age) voluntarily participated in the study. The SOL H-reflex was measured during passive and active shortening and lengthening muscle actions in a sitting position. The older group showed a lower ratio of the maximal amplitude of H-reflex to M-wave (SOL Hmax/Mmax) during the passive lengthening than that during the passive shortening (shortening: 0.40 ± 0.22 vs. lengthening: 0.15 ± 0.10, P shortening than that during the lengthening contractions at maximal effort (shortening: 0.51 ± 0.26 vs. lengthening: 0.37 ± 0.18, P muscle actions between young and older adults.

  8. Maximum permissible voltage of YBCO coated conductors

    Wen, J.; Lin, B.; Sheng, J.; Xu, J.; Jin, Z.; Hong, Z.; Wang, D.; Zhou, H.; Shen, X.; Shen, C.


    Superconducting fault current limiter (SFCL) could reduce short circuit currents in electrical power system. One of the most important thing in developing SFCL is to find out the maximum permissible voltage of each limiting element. The maximum permissible voltage is defined as the maximum voltage per unit length at which the YBCO coated conductors (CC) do not suffer from critical current (Ic) degradation or burnout. In this research, the time of quenching process is changed and voltage is raised until the Ic degradation or burnout happens. YBCO coated conductors test in the experiment are from American superconductor (AMSC) and Shanghai Jiao Tong University (SJTU). Along with the quenching duration increasing, the maximum permissible voltage of CC decreases. When quenching duration is 100 ms, the maximum permissible of SJTU CC, 12 mm AMSC CC and 4 mm AMSC CC are 0.72 V/cm, 0.52 V/cm and 1.2 V/cm respectively. Based on the results of samples, the whole length of CCs used in the design of a SFCL can be determined.

  9. Computing Rooted and Unrooted Maximum Consistent Supertrees

    van Iersel, Leo


    A chief problem in phylogenetics and database theory is the computation of a maximum consistent tree from a set of rooted or unrooted trees. A standard input are triplets, rooted binary trees on three leaves, or quartets, unrooted binary trees on four leaves. We give exact algorithms constructing rooted and unrooted maximum consistent supertrees in time O(2^n n^5 m^2 log(m)) for a set of m triplets (quartets), each one distinctly leaf-labeled by some subset of n labels. The algorithms extend to weighted triplets (quartets). We further present fast exact algorithms for constructing rooted and unrooted maximum consistent trees in polynomial space. Finally, for a set T of m rooted or unrooted trees with maximum degree D and distinctly leaf-labeled by some subset of a set L of n labels, we compute, in O(2^{mD} n^m m^5 n^6 log(m)) time, a tree distinctly leaf-labeled by a maximum-size subset X of L that all trees in T, when restricted to X, are consistent with.

  10. Maximum magnitude earthquakes induced by fluid injection

    McGarr, Arthur F.


    Analysis of numerous case histories of earthquake sequences induced by fluid injection at depth reveals that the maximum magnitude appears to be limited according to the total volume of fluid injected. Similarly, the maximum seismic moment seems to have an upper bound proportional to the total volume of injected fluid. Activities involving fluid injection include (1) hydraulic fracturing of shale formations or coal seams to extract gas and oil, (2) disposal of wastewater from these gas and oil activities by injection into deep aquifers, and (3) the development of enhanced geothermal systems by injecting water into hot, low-permeability rock. Of these three operations, wastewater disposal is observed to be associated with the largest earthquakes, with maximum magnitudes sometimes exceeding 5. To estimate the maximum earthquake that could be induced by a given fluid injection project, the rock mass is assumed to be fully saturated, brittle, to respond to injection with a sequence of earthquakes localized to the region weakened by the pore pressure increase of the injection operation and to have a Gutenberg-Richter magnitude distribution with a b value of 1. If these assumptions correctly describe the circumstances of the largest earthquake, then the maximum seismic moment is limited to the volume of injected liquid times the modulus of rigidity. Observations from the available case histories of earthquakes induced by fluid injection are consistent with this bound on seismic moment. In view of the uncertainties in this analysis, however, this should not be regarded as an absolute physical limit.

  11. Maximum magnitude earthquakes induced by fluid injection

    McGarr, A.


    Analysis of numerous case histories of earthquake sequences induced by fluid injection at depth reveals that the maximum magnitude appears to be limited according to the total volume of fluid injected. Similarly, the maximum seismic moment seems to have an upper bound proportional to the total volume of injected fluid. Activities involving fluid injection include (1) hydraulic fracturing of shale formations or coal seams to extract gas and oil, (2) disposal of wastewater from these gas and oil activities by injection into deep aquifers, and (3) the development of enhanced geothermal systems by injecting water into hot, low-permeability rock. Of these three operations, wastewater disposal is observed to be associated with the largest earthquakes, with maximum magnitudes sometimes exceeding 5. To estimate the maximum earthquake that could be induced by a given fluid injection project, the rock mass is assumed to be fully saturated, brittle, to respond to injection with a sequence of earthquakes localized to the region weakened by the pore pressure increase of the injection operation and to have a Gutenberg-Richter magnitude distribution with a b value of 1. If these assumptions correctly describe the circumstances of the largest earthquake, then the maximum seismic moment is limited to the volume of injected liquid times the modulus of rigidity. Observations from the available case histories of earthquakes induced by fluid injection are consistent with this bound on seismic moment. In view of the uncertainties in this analysis, however, this should not be regarded as an absolute physical limit.

  12. Spatiotemporal velocity-velocity correlation function in fully developed turbulence

    Canet, Léonie; Wschebor, Nicolás; Balarac, Guillaume


    Turbulence is an ubiquitous phenomenon in natural and industrial flows. Since the celebrated work of Kolmogorov in 1941, understanding the statistical properties of fully developed turbulence has remained a major quest. In particular, deriving the properties of turbulent flows from a mesoscopic description, that is from Navier-Stokes equation, has eluded most theoretical attempts. Here, we provide a theoretical prediction for the {\\it space and time} dependent velocity-velocity correlation function of homogeneous and isotropic turbulence from the field theory associated to Navier-Stokes equation with stochastic forcing. This prediction is the analytical fixed-point solution of Non-Perturbative Renormalisation Group flow equations, which are exact in a certain large wave-number limit. This solution is compared to two-point two-times correlation functions computed in direct numerical simulations. We obtain a remarkable agreement both in the inertial and in the dissipative ranges.

  13. Maximum Multiflow in Wireless Network Coding

    Zhou, Jin-Yi; Jiang, Yong; Zheng, Hai-Tao


    In a multihop wireless network, wireless interference is crucial to the maximum multiflow (MMF) problem, which studies the maximum throughput between multiple pairs of sources and sinks. In this paper, we observe that network coding could help to decrease the impacts of wireless interference, and propose a framework to study the MMF problem for multihop wireless networks with network coding. Firstly, a network model is set up to describe the new conflict relations modified by network coding. Then, we formulate a linear programming problem to compute the maximum throughput and show its superiority over one in networks without coding. Finally, the MMF problem in wireless network coding is shown to be NP-hard and a polynomial approximation algorithm is proposed.

  14. Exceptional Ground Accelerations and Velocities Caused by Earthquakes

    Anderson, John


    This project aims to understand the characteristics of the free-field strong-motion records that have yielded the 100 largest peak accelerations and the 100 largest peak velocities recorded to date. The peak is defined as the maximum magnitude of the acceleration or velocity vector during the strong shaking. This compilation includes 35 records with peak acceleration greater than gravity, and 41 records with peak velocities greater than 100 cm/s. The results represent an estimated 150,000 instrument-years of strong-motion recordings. The mean horizontal acceleration or velocity, as used for the NGA ground motion models, is typically 0.76 times the magnitude of this vector peak. Accelerations in the top 100 come from earthquakes as small as magnitude 5, while velocities in the top 100 all come from earthquakes with magnitude 6 or larger. Records are dominated by crustal earthquakes with thrust, oblique-thrust, or strike-slip mechanisms. Normal faulting mechanisms in crustal earthquakes constitute under 5% of the records in the databases searched, and an even smaller percentage of the exceptional records. All NEHRP site categories have contributed exceptional records, in proportions similar to the extent that they are represented in the larger database.

  15. Reconstructing gravity beyond the local universe with peculiar velocities

    Johnston, Russell; Teodoro, Luis F A; Nichol, Robert C; Warren, Michael S; Cress, Catherine


    We study a maximum probability approach to reconstructing spatial maps of the Newtonian gravitational potential, \\Psi, from peculiar velocities of galaxies at redshifts beyond z~0.1, where peculiar velocities have been measured from distance indicators (DI) such as the Tully-Fisher relation. With the large statistical uncertainties associated with DIs (of the order ~20% in distance), our reconstruction method aims to recover the underlying true peculiar velocity field with sufficient precision to be used as a cosmological probe of gravity, by reducing these statistical errors with the use of two physically motivated filtering prior terms. The first constructs an estimate of the velocity field derived from the galaxy over-density, \\delta_g, and the second makes use of the matter linear density power spectrum P(k). Through the use of N-body simulations we demonstrate that, with measurements with a suitably high signal-to-noise, we can successfully reconstruct the velocity and gravitational potential field out t...


    LI Zhong; LI Chunfeng


    The ring expansion procedures over various forming velocities are calculated with ANSYS software in order to show the effect of forming velocity on ductility of rate insensitive materials. Ring expansion procedures are simplified to one-dimensional tension by constraining the radial deformation, with element birth and death method, fracture problem of circular ring are considered. The calculated results show that for insensitive materials of 1060 aluminum and 3A21 aluminum alloy, fracture strain increases corresponding to the increase of forming velocity. This trend agrees well with experimental results, and indicates inertia is the key factor to affect ductility; With element birth and death methods, fracture problems can be solved effectively. Experimental studies on formability of tubular workpieces are also conducted, experimental results show that the formability of 1060 aluminum and 3A21 aluminum alloy under electromagnetic forming is higher than that under quasistatic forming, according to the characteristics of electromagnetic forming, the forming limit diagrams of the two materials tube are also built respectively, this is very important to promote the development of electromagnetic forming and guide the engineering practices.

  17. Dynamic Modulation of Myelination in Response to Visual Stimuli Alters Optic Nerve Conduction Velocity

    Etxeberria, Ainhoa; Hokanson, Kenton C.; Dao, Dang Q.; Mayoral, Sonia R.; Mei, Feng; Redmond, Stephanie A.; Ullian, Erik M.


    Myelin controls the time required for an action potential to travel from the neuronal soma to the axon terminal, defining the temporal manner in which information is processed within the CNS. The presence of myelin, the internodal length, and the thickness of the myelin sheath are powerful structural factors that control the velocity and fidelity of action potential transmission. Emerging evidence indicates that myelination is sensitive to environmental experience and neuronal activity. Activity-dependent modulation of myelination can dynamically alter action potential conduction properties but direct functional in vivo evidence and characterization of the underlying myelin changes is lacking. We demonstrate that in mice long-term monocular deprivation increases oligodendrogenesis in the retinogeniculate pathway but shortens myelin internode lengths without affecting other structural properties of myelinated fibers. We also demonstrate that genetically attenuating synaptic glutamate neurotransmission from retinal ganglion cells phenocopies the changes observed after monocular deprivation, suggesting that glutamate may constitute a signal for myelin length regulation. Importantly, we demonstrate that visual deprivation and shortened internodes are associated with a significant reduction in nerve conduction velocity in the optic nerve. Our results reveal the importance of sensory input in the building of myelinated fibers and suggest that this activity-dependent alteration of myelination is important for modifying the conductive properties of brain circuits in response to environmental experience. SIGNIFICANCE STATEMENT Oligodendrocyte precursor cells differentiate into mature oligodendrocytes and are capable of ensheathing axons with myelin without molecular cues from neurons. However, this default myelination process can be modulated by changes in neuronal activity. Here, we show, for the first time, that experience-dependent activity modifies the length of myelin

  18. The Wiener maximum quadratic assignment problem

    Cela, Eranda; Woeginger, Gerhard J


    We investigate a special case of the maximum quadratic assignment problem where one matrix is a product matrix and the other matrix is the distance matrix of a one-dimensional point set. We show that this special case, which we call the Wiener maximum quadratic assignment problem, is NP-hard in the ordinary sense and solvable in pseudo-polynomial time. Our approach also yields a polynomial time solution for the following problem from chemical graph theory: Find a tree that maximizes the Wiener index among all trees with a prescribed degree sequence. This settles an open problem from the literature.

  19. Maximum confidence measurements via probabilistic quantum cloning

    Zhang Wen-Hai; Yu Long-Bao; Cao Zhuo-Liang; Ye Liu


    Probabilistic quantum cloning (PQC) cannot copy a set of linearly dependent quantum states.In this paper,we show that if incorrect copies are allowed to be produced,linearly dependent quantum states may also be cloned by the PQC.By exploiting this kind of PQC to clone a special set of three linearly dependent quantum states,we derive the upper bound of the maximum confidence measure of a set.An explicit transformation of the maximum confidence measure is presented.

  20. Maximum floodflows in the conterminous United States

    Crippen, John R.; Bue, Conrad D.


    Peak floodflows from thousands of observation sites within the conterminous United States were studied to provide a guide for estimating potential maximum floodflows. Data were selected from 883 sites with drainage areas of less than 10,000 square miles (25,900 square kilometers) and were grouped into regional sets. Outstanding floods for each region were plotted on graphs, and envelope curves were computed that offer reasonable limits for estimates of maximum floods. The curves indicate that floods may occur that are two to three times greater than those known for most streams.