WorldWideScience

Sample records for maturity programming concepts

  1. Space Mission Concept Development Using Concept Maturity Levels

    Science.gov (United States)

    Wessen, Randii R.; Borden, Chester; Ziemer, John; Kwok, Johnny

    2013-01-01

    Over the past five years, pre-project formulation experts at the Jet Propulsion Laboratory (JPL) has developed and implemented a method for measuring and communicating the maturity of space mission concepts. Mission concept development teams use this method, and associated tools, prior to concepts entering their Formulation Phases (Phase A/B). The organizing structure is Concept Maturity Level (CML), which is a classification system for characterizing the various levels of a concept's maturity. The key strength of CMLs is the ability to evolve mission concepts guided by an incremental set of assessment needs. The CML definitions have been expanded into a matrix form to identify the breadth and depth of analysis needed for a concept to reach a specific level of maturity. This matrix enables improved assessment and communication by addressing the fundamental dimensions (e.g., science objectives, mission design, technical risk, project organization, cost, export compliance, etc.) associated with mission concept evolution. JPL's collaborative engineering, dedicated concept development, and proposal teams all use these and other CML-appropriate design tools to advance their mission concept designs. This paper focuses on mission concept's early Pre-Phase A represented by CMLs 1- 4. The scope was limited due to the fact that CMLs 5 and 6 are already well defined based on the requirements documented in specific Announcement of Opportunities (AO) and Concept Study Report (CSR) guidelines, respectively, for competitive missions; and by NASA's Procedural Requirements NPR 7120.5E document for Projects in their Formulation Phase.

  2. Human development: from conception to maturity

    Directory of Open Access Journals (Sweden)

    Valdemiro Carlos Sgarbieri

    2017-05-01

    Full Text Available Abstract The main objective of this review was to describe and emphasize the care that a woman must have in the period prior to pregnancy, as well as throughout pregnancy and after the birth of the baby, cares and duties that should continue to be followed by mother and child throughout the first years of the child’s life. Such cares are of nutritional, behavioral and lifestyle natures, and also involve the father and the whole family. Human development, from conception to maturity, consists of a critical and important period due to the multitude of intrinsic genetic and environmental factors that influence, positively or negatively, the person's entire life. The human being, who originated and passed his/her first phase of development in the womb, receives influence from different factors: a of parental origin (father and mother, including health and lifestyle of the father and mother, genetic inheritance, nutrition of the mother prior to and during pregnancy; b events that affected the mother and hence the child under development in intrauterine life, at birth (delivery, during perinatal period, and throughout the early years of life. The fragility of development continues throughout the preschool, school and adolescent periods during which proper nutrition with a balanced lifestyle is essential and depends on guidance from the parents, caregivers and teachers.

  3. Concept medium program

    DEFF Research Database (Denmark)

    Bjerrum, Peter

    2003-01-01

    The present essays is an attempt to dertermine the architecural project of the 21st century in realation to a modern conception of space as the medium of architecture, and of society as its program. This attempt adopts the internal point of view of an architect in describing a modern architectural...... project within the framework: concept - program, these notions being concieved as spatial representations primarily and immediately "given" to architecture....

  4. Advanced fusion concepts program

    International Nuclear Information System (INIS)

    Dove, W.F.

    1978-01-01

    While the prospects for the eventual development of a tokamak-based fusion reactor appear promising at the present time, the Department of Energy maintains a vigorous program in alternate magnetic fusion concepts. Several of the concepts presently supported include the toroidal reversed field pinch, Tormac, Elmo Bumpy Torus, and various linear options. Recent technical accomplishments and program evaluations indicate that the possibility now exists for undertaking the next development stage, a proof-of-principle experiment, for a few of the most promising alternate concepts

  5. Transcriptional Programs Controlling Perinatal Lung Maturation

    Science.gov (United States)

    Xu, Yan; Wang, Yanhua; Besnard, Valérie; Ikegami, Machiko; Wert, Susan E.; Heffner, Caleb; Murray, Stephen A.; Donahue, Leah Rae; Whitsett, Jeffrey A.

    2012-01-01

    The timing of lung maturation is controlled precisely by complex genetic and cellular programs. Lung immaturity following preterm birth frequently results in Respiratory Distress Syndrome (RDS) and Broncho-Pulmonary Dysplasia (BPD), which are leading causes of mortality and morbidity in preterm infants. Mechanisms synchronizing gestational length and lung maturation remain to be elucidated. In this study, we designed a genome-wide mRNA expression time-course study from E15.5 to Postnatal Day 0 (PN0) using lung RNAs from C57BL/6J (B6) and A/J mice that differ in gestational length by ∼30 hr (B6controlling lung maturation. We identified both temporal and strain dependent gene expression patterns during lung maturation. For time dependent changes, cell adhesion, vasculature development, and lipid metabolism/transport were major bioprocesses induced during the saccular stage of lung development at E16.5–E17.5. CEBPA, PPARG, VEGFA, CAV1 and CDH1 were found to be key signaling and transcriptional regulators of these processes. Innate defense/immune responses were induced at later gestational ages (E18.5–20.5), STAT1, AP1, and EGFR being important regulators of these responses. Expression of RNAs associated with the cell cycle and chromatin assembly was repressed during prenatal lung maturation and was regulated by FOXM1, PLK1, chromobox, and high mobility group families of transcription factors. Strain dependent lung mRNA expression differences peaked at E18.5. At this time, mRNAs regulating surfactant and innate immunity were more abundantly expressed in lungs of B6 (short gestation) than in A/J (long gestation) mice, while expression of genes involved in chromatin assembly and histone modification were expressed at lower levels in B6 than in A/J mice. The present study systemically mapped key regulators, bioprocesses, and transcriptional networks controlling lung maturation, providing the basis for new therapeutic strategies to enhance lung function in preterm

  6. Programming Language: Concepts and Paradigms

    OpenAIRE

    Ruiz Lizama, Edgar

    2014-01-01

    The article presents the concepts that govern around the programming languages and the paradigms of the programming and the influence in the development of the software. El artículo presenta los conceptos que rigen a los lenguajes de programación y los paradigmas de la programación y como estos influyen en el desarrollo del software.

  7. Career Maturity of Students in Accelerated versus Traditional Programs

    Science.gov (United States)

    Borges, Nicole J.; Richard, George V.; Duffy, Ryan D.

    2007-01-01

    The authors assessed the career maturity of students in accelerated versus traditional academic programs. Students in traditional programs were hypothesized to be more advanced regarding their career decision making and development when compared with students in accelerated programs. The Medical Career Development Inventory (see M. L. Savickas,…

  8. Comparison of State-Funded Technology Maturation Programs.

    Energy Technology Data Exchange (ETDEWEB)

    Keller, Elizabeth James Kistin [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Warren, Drake [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Hess, Marguerite Evelyn [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)

    2016-12-01

    This study examines the structure and impact of state-funded technology maturation programs that leverage research institutions for economic development throughout the United States. The lessons learned and practices identified from previous experiences will inform Sandia National Laboratories' Government Relations and Technology Partnerships teams as they participate in near-term discussions about the proposed Technology Readiness Gross Receipts Tax Credit and Program, and continue to shape longer-term program and partnership opportunities. This Page Intentionally Left Blank

  9. Development and Implementation of a Program Management Maturity Model

    Energy Technology Data Exchange (ETDEWEB)

    Hartwig, Laura; Smith, Matt

    2008-12-15

    In 2006, Honeywell Federal Manufacturing & Technologies (FM&T) announced an updatedvision statement for the organization. The vision is “To be the most admired team within the NNSA [National Nuclear Security Administration] for our relentless drive to convert ideas into the highest quality products and services for National Security by applying the right technology, outstanding program management and best commercial practices.” The challenge to provide outstanding program management was taken up by the Program Management division and the Program Integration Office (PIO) of the company. This article describes how Honeywell developed and deployed a program management maturity model to drive toward excellence.

  10. The Concept of the Relationship between Information System Maturity and Industry Performance in Indonesia

    Science.gov (United States)

    Palilingan, V. R.; Mario, T. P.

    2018-01-01

    Industry in Indonesia continues to grow from year to year. Along with these developments, the use of information technology, which is the basis of information systems, should be considered as a handy tool to survive in the competition in the industry. Various previous studies have discussed much the use of information systems and their role at the strategic level. But more in-depth research is still needed to find out the extent to which the maturity of the use of information systems through its elements can affect the performance of companies in various sectors industries in Indonesia. It is hoped that this concept can be used as a subsequent research by distributing questionnaires based on the method of statements that have been defined by researchers. With this concepts, the next development will continue to measure the relationship information systems maturity in general with the organizations performance. The result of the concept proposed by the researcher is expected to be able to measure the maturity relationship of an information system with the connection with the consumer, demand/supply planning element, innovation, performance measurement, IT impact management and also internal process.

  11. Identifying difficult concepts in introductory programming

    OpenAIRE

    Humar, Klaudija

    2014-01-01

    In this diploma thesis we try to find the answer to why students experience difficulties in introductory programming. We ask ourselves what causes most problems while trying to understand concepts in introductory programming, generating code and designing algorithms. In the first section we introduce programming language Python as the first programming language being taught to students. We compare it with programming language Pascal and stress the advantages of Python that seem important ...

  12. A Playful Programming Products Vs. Programming Concepts Matrix

    DEFF Research Database (Denmark)

    Allsopp, Benjamin Brink

    2017-01-01

    to computer program: playful programming. This research also describes a project to bring together different stakeholders (developers, educators, parents and researchers) with a common vocabulary for describing, developing, teaching with and comparing these playful programming products and develops a model......A number of Danish primary schools are involved in pilot studies where 1st to 9th grade students work with Scratch and Lego MindStorms in STEM subjects. These games may become part of the curriculum at these schools. Recent research identifies a category of games and toys that support learning...... to provide educators and researchers involved in pilot studies with an overview of which programming concepts various playful programming products exercise (a playful programming products vs. programming concepts matrix). We also add additional concept specializations and expand on the descriptions...

  13. Programming language concepts for software developers

    DEFF Research Database (Denmark)

    Sestoft, Peter

    2008-01-01

    This note describes and motivates our current plans for an undergraduate course on programming language concepts for software development students. We describe the competences we expect students to acquire as well as the topics covered by the course. We plan to use C# and Scheme as instruction...

  14. Cryogenic fluid management program flight concept definition

    Science.gov (United States)

    Kroeger, Erich

    1987-01-01

    The Lewis Research Center's cryogenic fluid management program flight concept definition is presented in viewgraph form. Diagrams are given of the cryogenic fluid management subpallet and its configuration with the Delta launch vehicle. Information is given in outline form on feasibility studies, requirements definition, and flight experiments design.

  15. CTCF counter-regulates cardiomyocyte development and maturation programs in the embryonic heart

    NARCIS (Netherlands)

    M. Gomez-Velazquez (Melisa); C. Badia-Careaga (Claudio); Lechuga-Vieco, A.V. (Ana Victoria); Nieto-Arellano, R. (Rocio); Tena, J.J. (Juan J.); Rollan, I. (Isabel); Alvarez, A. (Alba); Torroja, C. (Carlos); Caceres, E.F. (Eva F.); Roy, A. (Anna); N.J. Galjart (Niels); Delgado-Olguin, P. (Paul); F. Sánchez-Cabo (Fátima); Enriquez, J.A. (Jose Antonio); Gomez-Skarmeta, J.L. (Jose Luis); M. Manzanares (Miguel)

    2017-01-01

    textabstractCardiac progenitors are specified early in development and progressively differentiate and mature into fully functional cardiomyocytes. This process is controlled by an extensively studied transcriptional program. However, the regulatory events coordinating the progression of such

  16. Eletrobras management program in ergonomics: the pursuit of excellence through maturity levels.

    Science.gov (United States)

    Pires, Paulo Roberto de Oliveira Bassil; Rezende, Fagner Fagundes

    2012-01-01

    Ergonomics for Eletrobras arose from the need in having an environment more suitable to the characteristics and circumstances of employees, in compliance with Regulation Standard no. 17 - Ergonomics (NR17) of the Ministry of Labor and Employment. Being a mixed economy company with regionalized anthropometric characteristics of its employees, the study of ergonomic adjustments and improvement of the concept of Ergonomics were and have been of great importance to the company's production environment. These advances have contributed to the development of specific technical criteria for the purchase of furniture and work tools (accessories), apart from their possible effects on the user. Ergonomics has been perceived as a technical-scientific tool, aimed to study labor interactions, new technologies and specific characteristics of the activities performed. To meet these demands a multidisciplinary Ergonomics Committee was created in Eletrobras, and effectively established the Ergonomics Management Program in the company; This program is marked by well-defined phases with great success in making use of these studies for other types of corporate activities and also facilitating the program control and its maturity levels, even at a business level.

  17. The Influence of Self-Concept, Parenting Style and Individualism-Collectivism on Career Maturity in Australia and Thailand

    Science.gov (United States)

    Hughes, Catherine

    2011-01-01

    Relationships between career maturity and self-concept, parenting style and individualism-collectivism across Australian and Thai cultural contexts were investigated. Berry's ("1969") etic-emic model for adapting instruments for cross-cultural research was applied. "Derived etic" status was achieved for the career planning…

  18. The direct liquefaction proof of concept program

    Energy Technology Data Exchange (ETDEWEB)

    Comolli, A.G.; Lee, L.K.; Pradhan, V.R.; Stalzer, R.H. [New York & Puritan Avenues, Lawrenceville, NJ (United States)

    1995-12-31

    The goal of the Proof of Concept (POC) Program is to develop Direct Coal Liquefaction and associated transitional technologies towards commercial readiness for economically producing premium liquid fuels from coal in an environmentally acceptable manner. The program focuses on developing the two-stage liquefaction (TSL) process by utilizing geographically strategic feedstocks, commercially feasible catalysts, new prototype equipment, and testing co-processing or alternate feedstocks and improved process configurations. Other high priority objectives include dispersed catalyst studies, demonstrating low rank coal liquefaction without solids deposition, improving distillate yields on a unit reactor volume basis, demonstrating ebullated bed operations while obtaining scale-up data, demonstrating optimum catalyst consumption using new concepts (e.g. regeneration, cascading), producing premium products through on-line hydrotreating, demonstrating improved hydrogen utilization for low rank coals using novel heteroatom removal methods, defining and demonstrating two-stage product properties for upgrading; demonstrating efficient and economic solid separation methods, examining the merits of integrated coal cleaning, demonstrating co-processing, studying interactions between the preheater and first and second-stage reactors, improving process operability by testing and incorporating advanced equipment and instrumentation, and demonstrating operation with alternate coal feedstocks. During the past two years major PDU Proof of Concept runs were completed. POC-1 with Illinois No. 6 coal and POC-2 with Black Thunder sub-bituminous coal. Results from these operations are continuing under review and the products are being further refined and upgraded. This paper will update the results from these operations and discuss future plans for the POC program.

  19. Emotional Maturity of Adolescents and Adults in GED Programs

    Science.gov (United States)

    Riffle, Billy Joe

    2010-01-01

    When discussing issues relating to students in General Educational Development (GED) Option and pre-GED programs with educators, the contention exists that it is possible to make reasonably accurate predictions on the success or failure of a student by observing a number of items. Looking at their cumulative records shows their academic and…

  20. Application of Lean Manufacturing in Hospitals-the Need to Consider Maturity, Complexity, and the Value Concept

    DEFF Research Database (Denmark)

    Hasle, Peter; Nielsen, Anders Paarup; Edwards, Kasper

    2016-01-01

    Lean is widely applied in hospitals, but the impact tends to be limited. This paper investigates three possible explanations: 1) maturity, 2) complexity, and 3) the value concept and analyses the bearing of these in a case study of lean application in a large Danish university hospital. The results...... indicate that lean tends to be applied in secondary and support functions with a logistic character and therefore has had a limited impact on the overall healthcare performance. The case study shows that there are constraints related to low lean maturity, the complexity of processes and operations as well...... in hospitals in order to bring about a larger impact. It is therefore necessary to develop new models for the lean concept as well as the implementation of lean adapted to the particular context of hospitals with a stronger focus on patient experiences and on coordination of social relations....

  1. CTCF counter-regulates cardiomyocyte development and maturation programs in the embryonic heart.

    Directory of Open Access Journals (Sweden)

    Melisa Gomez-Velazquez

    2017-08-01

    Full Text Available Cardiac progenitors are specified early in development and progressively differentiate and mature into fully functional cardiomyocytes. This process is controlled by an extensively studied transcriptional program. However, the regulatory events coordinating the progression of such program from development to maturation are largely unknown. Here, we show that the genome organizer CTCF is essential for cardiogenesis and that it mediates genomic interactions to coordinate cardiomyocyte differentiation and maturation in the developing heart. Inactivation of Ctcf in cardiac progenitor cells and their derivatives in vivo during development caused severe cardiac defects and death at embryonic day 12.5. Genome wide expression analysis in Ctcf mutant hearts revealed that genes controlling mitochondrial function and protein production, required for cardiomyocyte maturation, were upregulated. However, mitochondria from mutant cardiomyocytes do not mature properly. In contrast, multiple development regulatory genes near predicted heart enhancers, including genes in the IrxA cluster, were downregulated in Ctcf mutants, suggesting that CTCF promotes cardiomyocyte differentiation by facilitating enhancer-promoter interactions. Accordingly, loss of CTCF disrupts gene expression and chromatin interactions as shown by chromatin conformation capture followed by deep sequencing. Furthermore, CRISPR-mediated deletion of an intergenic CTCF site within the IrxA cluster alters gene expression in the developing heart. Thus, CTCF mediates local regulatory interactions to coordinate transcriptional programs controlling transitions in morphology and function during heart development.

  2. CTCF counter-regulates cardiomyocyte development and maturation programs in the embryonic heart

    Science.gov (United States)

    Gomez-Velazquez, Melisa; Badia-Careaga, Claudio; Lechuga-Vieco, Ana Victoria; Nieto-Arellano, Rocio; Rollan, Isabel; Alvarez, Alba; Torroja, Carlos; Caceres, Eva F.; Roy, Anna R.; Galjart, Niels; Sanchez-Cabo, Fatima; Enriquez, Jose Antonio; Gomez-Skarmeta, Jose Luis

    2017-01-01

    Cardiac progenitors are specified early in development and progressively differentiate and mature into fully functional cardiomyocytes. This process is controlled by an extensively studied transcriptional program. However, the regulatory events coordinating the progression of such program from development to maturation are largely unknown. Here, we show that the genome organizer CTCF is essential for cardiogenesis and that it mediates genomic interactions to coordinate cardiomyocyte differentiation and maturation in the developing heart. Inactivation of Ctcf in cardiac progenitor cells and their derivatives in vivo during development caused severe cardiac defects and death at embryonic day 12.5. Genome wide expression analysis in Ctcf mutant hearts revealed that genes controlling mitochondrial function and protein production, required for cardiomyocyte maturation, were upregulated. However, mitochondria from mutant cardiomyocytes do not mature properly. In contrast, multiple development regulatory genes near predicted heart enhancers, including genes in the IrxA cluster, were downregulated in Ctcf mutants, suggesting that CTCF promotes cardiomyocyte differentiation by facilitating enhancer-promoter interactions. Accordingly, loss of CTCF disrupts gene expression and chromatin interactions as shown by chromatin conformation capture followed by deep sequencing. Furthermore, CRISPR-mediated deletion of an intergenic CTCF site within the IrxA cluster alters gene expression in the developing heart. Thus, CTCF mediates local regulatory interactions to coordinate transcriptional programs controlling transitions in morphology and function during heart development. PMID:28846746

  3. CTCF counter-regulates cardiomyocyte development and maturation programs in the embryonic heart.

    Science.gov (United States)

    Gomez-Velazquez, Melisa; Badia-Careaga, Claudio; Lechuga-Vieco, Ana Victoria; Nieto-Arellano, Rocio; Tena, Juan J; Rollan, Isabel; Alvarez, Alba; Torroja, Carlos; Caceres, Eva F; Roy, Anna R; Galjart, Niels; Delgado-Olguin, Paul; Sanchez-Cabo, Fatima; Enriquez, Jose Antonio; Gomez-Skarmeta, Jose Luis; Manzanares, Miguel

    2017-08-01

    Cardiac progenitors are specified early in development and progressively differentiate and mature into fully functional cardiomyocytes. This process is controlled by an extensively studied transcriptional program. However, the regulatory events coordinating the progression of such program from development to maturation are largely unknown. Here, we show that the genome organizer CTCF is essential for cardiogenesis and that it mediates genomic interactions to coordinate cardiomyocyte differentiation and maturation in the developing heart. Inactivation of Ctcf in cardiac progenitor cells and their derivatives in vivo during development caused severe cardiac defects and death at embryonic day 12.5. Genome wide expression analysis in Ctcf mutant hearts revealed that genes controlling mitochondrial function and protein production, required for cardiomyocyte maturation, were upregulated. However, mitochondria from mutant cardiomyocytes do not mature properly. In contrast, multiple development regulatory genes near predicted heart enhancers, including genes in the IrxA cluster, were downregulated in Ctcf mutants, suggesting that CTCF promotes cardiomyocyte differentiation by facilitating enhancer-promoter interactions. Accordingly, loss of CTCF disrupts gene expression and chromatin interactions as shown by chromatin conformation capture followed by deep sequencing. Furthermore, CRISPR-mediated deletion of an intergenic CTCF site within the IrxA cluster alters gene expression in the developing heart. Thus, CTCF mediates local regulatory interactions to coordinate transcriptional programs controlling transitions in morphology and function during heart development.

  4. Assessment of the Technical Maturity of Generation IV Concepts for Test or Demonstration Reactor Applications, Revision 2

    Energy Technology Data Exchange (ETDEWEB)

    Gougar, Hans David [Idaho National Lab. (INL), Idaho Falls, ID (United States)

    2015-10-01

    The United States Department of Energy (DOE) commissioned a study the suitability of different advanced reactor concepts to support materials irradiations (i.e. a test reactor) or to demonstrate an advanced power plant/fuel cycle concept (demonstration reactor). As part of the study, an assessment of the technical maturity of the individual concepts was undertaken to see which, if any, can support near-term deployment. A Working Group composed of the authors of this document performed the maturity assessment using the Technical Readiness Levels as defined in DOE’s Technology Readiness Guide . One representative design was selected for assessment from of each of the six Generation-IV reactor types: gas-cooled fast reactor (GFR), lead-cooled fast reactor (LFR), molten salt reactor (MSR), supercritical water-cooled reactor (SCWR), sodium-cooled fast reactor (SFR), and very high temperature reactor (VHTR). Background information was obtained from previous detailed evaluations such as the Generation-IV Roadmap but other technical references were also used including consultations with concept proponents and subject matter experts. Outside of Generation IV activity in which the US is a party, non-U.S. experience or data sources were generally not factored into the evaluations as one cannot assume that this data is easily available or of sufficient quality to be used for licensing a US facility. The Working Group established the scope of the assessment (which systems and subsystems needed to be considered), adapted a specific technology readiness scale, and scored each system through discussions designed to achieve internal consistency across concepts. In general, the Working Group sought to determine which of the reactor options have sufficient maturity to serve either the test or demonstration reactor missions.

  5. An Environmental Management Maturity Model of Construction Programs Using the AHP-Entropy Approach

    Directory of Open Access Journals (Sweden)

    Libiao Bai

    2018-06-01

    Full Text Available The accelerating process of urbanization in China has led to considerable opportunities for the development of construction projects, however, environmental issues have become an important constraint on the implementation of these projects. To quantitatively describe the environmental management capabilities of such projects, this paper proposes a 2-dimensional Environmental Management Maturity Model of Construction Program (EMMMCP based on an analysis of existing projects, group management theory and a management maturity model. In this model, a synergetic process was included to compensate for the lack of consideration of synergies in previous studies, and it was involved in the construction of the first dimension, i.e., the environmental management index system. The second dimension, i.e., the maturity level of environment management, was then constructed by redefining the hierarchical characteristics of construction program (CP environmental management maturity. Additionally, a mathematical solution to this proposed model was derived via the Analytic Hierarchy Process (AHP-entropy approach. To verify the effectiveness and feasibility of this proposed model, a computational experiment was conducted, and the results show that this approach could not only measure the individual levels of different processes, but also achieve the most important objective of providing a reference for stakeholders when making decisions on the environmental management of construction program, which reflects this model is reasonable for evaluating the level of environmental management maturity in CP. To our knowledge, this paper is the first study to evaluate the environmental management maturity levels of CP, which would fill the gap between project program management and environmental management and provide a reference for relevant management personnel to enhance their environmental management capabilities.

  6. Advanced concepts in the United States fusion program

    International Nuclear Information System (INIS)

    Dove, W.F.

    1985-01-01

    The goal of the magnetic fusion program is to establish the scientific and technological base for fusion energy. Development of a variety of magnetic confinement systems is essential to achieving that goal. The role of the advanced concepts program is to conduct experimental investigations of confinement concepts other than the tokamaks and tandem mirror concepts. The present advanced concepts program consists of the reversed-field-pinch (RFP), the spheromak and the field-reversed configuration (FRC). Significant new experiments in the RFP and FRC concepts have been approved and are described

  7. Extending the concept and modularization of project management maturity with adaptable, human and customer factors

    NARCIS (Netherlands)

    Beverly Pasian

    2014-01-01

    Purpose The conceptual and modularization of project management maturity models is based on the principle of process control. This research was designed to challenge these boundaries to reveal non-process factors. The paper aims to discuss these issues. Design/methodology/approach A multimethod

  8. Human Research Program Advanced Exercise Concepts (AEC) Overview

    Science.gov (United States)

    Perusek, Gail; Lewandowski, Beth; Nall, Marsha; Norsk, Peter; Linnehan, Rick; Baumann, David

    2015-01-01

    Exercise countermeasures provide benefits that are crucial for successful human spaceflight, to mitigate the spaceflight physiological deconditioning which occurs during exposure to microgravity. The NASA Human Research Program (HRP) within the Human Exploration and Operations Mission Directorate (HEOMD) is managing next generation Advanced Exercise Concepts (AEC) requirements development and candidate technology maturation to Technology Readiness Level (TRL) 7 (ground prototyping and flight demonstration) for all exploration mission profiles from Multi Purpose Crew Vehicle (MPCV) Exploration Missions (up to 21 day duration) to Mars Transit (up to 1000 day duration) missions. These validated and optimized exercise countermeasures systems will be provided to the ISS Program and MPCV Program for subsequent flight development and operations. The International Space Station (ISS) currently has three major pieces of operational exercise countermeasures hardware: the Advanced Resistive Exercise Device (ARED), the second-generation (T2) treadmill, and the cycle ergometer with vibration isolation system (CEVIS). This suite of exercise countermeasures hardware serves as a benchmark and is a vast improvement over previous generations of countermeasures hardware, providing both aerobic and resistive exercise for the crew. However, vehicle and resource constraints for future exploration missions beyond low Earth orbit will require that the exercise countermeasures hardware mass, volume, and power be minimized, while preserving the current ISS capabilities or even enhancing these exercise capabilities directed at mission specific physiological functional performance and medical standards requirements. Further, mission-specific considerations such as preservation of sensorimotor function, autonomous and adaptable operation, integration with medical data systems, rehabilitation, and in-flight monitoring and feedback are being developed for integration with the exercise

  9. Technology Maturity for the Habitable-zone Exoplanet Imaging Mission (HabEx) Concept

    Science.gov (United States)

    Morgan, Rhonda; Warfield, Keith R.; Stahl, H. Philip; Mennesson, Bertrand; Nikzad, Shouleh; nissen, joel; Balasubramanian, Kunjithapatham; Krist, John; Mawet, Dimitri; Stapelfeldt, Karl; warwick, Steve

    2018-01-01

    HabEx Architecture A is a 4m unobscured telescope optimized for direct imaging and spectroscopy of potentially habitable exoplanets, and also enables a wide range of general astrophysics science. The exoplanet detection and characterization drives the enabling core technologies. A hybrid starlight suppression approach of a starshade and coronagraph diversifies technology maturation risk. In this poster we assess these exoplanet-driven technologies, including elements of coronagraphs, starshades, mirrors, jitter mitigation, wavefront control, and detectors. By utilizing high technology readiness solutions where feasible, and identifying required technology development that can begin early, HabEx will be well positioned for assessment by the community in 2020 Astrophysics Decadal Survey.

  10. Programming Language Concepts - The Lambda Calculus Approach

    NARCIS (Netherlands)

    Fokkinga, M.M.; Asveld, P.R.J.; Nijholt, Antinus

    1987-01-01

    The Lambda Calculus is a formal system, originally intended as a tool in the foundation of mathematics, but mainly used to study the concepts of algorithm and effective computability. Recently, the Lambda Calculus and related systems acquire attention from Computer Science for another reason too:

  11. Programming languages for MIS concepts and practice

    CERN Document Server

    Wang, Hai

    2014-01-01

    Introduction Computers Computer Programming Languages     Role of Computer Programming Language      Software Systems     Taxonomies of Computer Programming LanguagesComputing Architecture in the Internet Environment Key Characteristics Shared by All Procedural Programming Languages      Syntax, Sentence, and Word     Variable     Arithmetic Operation     Execution Sequence      If-Then-Else Logic      Loop      Module C++ Introduction to Function-Oriented and Object-Oriented Programming A Tour of C Language      C and C++ Keyword and User-Defined Word      Comment Statements      Preprocessor

  12. Emergency management: Concepts and strategies for effective programs

    OpenAIRE

    Lucus, Valerie

    2007-01-01

    Review of Emergency Management: Concepts and Strategies for Effective Programs By Lucien G. Canton, CEM. By taking a different perspective on local government emergency management programs, this book presents the vision for a very different model--one that includes an independent emergency manager leading an enterprise-wide program focused on strategies that promote disaster resilient communities.

  13. Operations monitoring concept. Consolidated Fuel Reprocessing Program

    International Nuclear Information System (INIS)

    Kerr, H.T.

    1985-01-01

    Operations monitoring is a safeguards concept which could be applied in future fuel cycle facilities to significantly enhance the effectiveness of an integrated safeguards system. In general, a variety of operations monitoring techniques could be developed for both international and domestic safeguards application. The goal of this presentation is to describe specific examples of operations monitoring techniques as may be applied in a fuel reprocessing facility. The operations monitoring concept involves monitoring certain in-plant equipment, personnel, and materials to detect conditions indicative of the diversion of nuclear material. An operations monitoring subsystem should be designed to monitor operations only to the extent necessary to achieve specified safeguards objectives; there is no intent to monitor all operations in the facility. The objectives of the operations monitoring subsystem include: verification of reported data; detection of undeclared uses of equipment; and alerting the inspector to potential diversion activities. 1 fig

  14. Service systems concepts, modeling, and programming

    CERN Document Server

    Cardoso, Jorge; Poels, Geert

    2014-01-01

    This SpringerBrief explores the internal workings of service systems. The authors propose a lightweight semantic model for an effective representation to capture the essence of service systems. Key topics include modeling frameworks, service descriptions and linked data, creating service instances, tool support, and applications in enterprises.Previous books on service system modeling and various streams of scientific developments used an external perspective to describe how systems can be integrated. This brief introduces the concept of white-box service system modeling as an approach to mo

  15. Using Programming Environments in Teaching GIS Concepts

    Directory of Open Access Journals (Sweden)

    Imre Bornemisza

    2009-03-01

    Full Text Available When teaching Geographical Information Systems (GIS it is important to explain the theoretical elements, but it is also necessary to illustrate the basic functions with examples. To help students it is advisable to separate the teaching of fundamentals from the practical application of complex GIS software. A simple programming language like Logo creates opportunities for acquiring knowledge in an easy way. The development of a program makes it possible tounderstand the most important categories. If the program contains query functions as well, students can learn more about problem solution methods.This paper also demonstrates the power of the Logo family of languages which is delivered by different implementations. Elica Logo is used to build simple GIS tools that provide a very widerange of educational problems and lead to numerous ideas for further explorations. The nice intuitive 3D interface is an attractive approach to gain and retain student’s engagement in thelearning process.

  16. ORGANIZATIONAL PROJECT MANAGEMENT MATURITY

    Directory of Open Access Journals (Sweden)

    Yana Derenskaya

    2017-11-01

    Full Text Available The present article is aimed at developing a set of recommendations for achieving a higher level of organizational project maturity at a given enterprise. Methodology. For the purposes of the current research, the available information sources on the components of project management system are analysed; the essence of “organizational maturity” and the existing models of organizational maturity are studied. The method of systemic and structural analysis, as well as the method of logical generalization, are employed in order to study the existing models of organizational maturity, to describe levels of organizational maturity, and finally to develop a set of methodological recommendations for achieving a higher level of organizational project maturity at a given enterprise. The results of the research showed that the core elements of project management system are methodological, organizational, programtechnical, and motivational components. Project management encompasses a wide range of issues connected with organizational structure, project team, communication management, project participants, etc. However, the fundamental basis for developing project management concept within a given enterprise starts with defining its level of organizational maturity. The present paper describes various models of organizational maturity (staged, continuous, petal-shaped and their common types (H. Кеrzner Organizational Maturity Model, Berkeley PM Maturity Model, Organizational Project Management Maturity Model, Portfolio, Program & Project Management Maturity Model. The analysis of available theoretic works showed that the notion “organizational project maturity” refers to the capability of an enterprise to select projects and manage them with the intention of achieving its strategic goals in the most effective way. Importantly, the level of maturity can be improved by means of formalizing the acquired knowledge, regulating project-related activities

  17. Company maturity models: Application to supplier development program in oil&gas sector

    Directory of Open Access Journals (Sweden)

    Jabier Retegi Albisua

    2018-04-01

    Full Text Available Purpose: In order to achieve excellence, outsourced maintenance contractors in Oil&Gas sector play a key role due to the important impact of their task on security, availability and energy consumption. This paper presents the process followed in order to implement a Supplier Development Program in a refinery using Company Maturity Model (CoMM and the results obtained in three cases validating the method to obtain a strategic improvement project medium term grid. Design/methodology/approach: The methodology followed consists of constructing a CoMM capturing the knowledge existing in the refinery and applying it with three supplier improvement teams. Findings and conclusions have arised through an observation of the three processes and extracting common conclusions. Findings: The resulting CoMM has been used for self-assessment by three suppliers and has demonstrated its potential to define a medium-term improvement project road map validated by the customer. Furthermore, during the design and application processes, the contribution of CoMMs to the SECI process of knowledge management has been observed. Practical implications: The use of CoMMs in a service contractor context can be applied in other sectors. It contributes to alignment of targets between the supplier and customer companies and to knowledge sharing inside both firms. Originality/value: Maturity models in many transversal fields (CMMI, EFQM, BPMM, PEMM, etc. have been thoroughly studied in the literature. Less effort has been made analysing the case of using maturity models constructed and implemented by a company for its specific purposes. In this paper, the process followed by a company to establish a Supplier Development Process using CoMMs is described.

  18. An overview of the NASA Advanced Propulsion Concepts program

    International Nuclear Information System (INIS)

    Curran, F.M.; Bennett, G.L.; Frisbee, R.H.; Sercel, J.C.; Lapointe, M.R.

    1992-07-01

    NASA Advanced Propulsion Concepts (APC) program for the development of long-term space propulsion system schemes is managed by both NASA-Lewis and the JPL and is tasked with the identification and conceptual development of high-risk/high-payoff configurations. Both theoretical and experimental investigations have been undertaken in technology areas deemed essential to the implementation of candidate concepts. These APC candidates encompass very high energy density chemical propulsion systems, advanced electric propulsion systems, and an antiproton-catalyzed nuclear propulsion concept. A development status evaluation is presented for these systems. 45 refs

  19. Dendritic cell maturation: functional specialization through signaling specificity and transcriptional programming.

    Science.gov (United States)

    Dalod, Marc; Chelbi, Rabie; Malissen, Bernard; Lawrence, Toby

    2014-05-16

    Dendritic cells (DC) are key regulators of both protective immune responses and tolerance to self-antigens. Soon after their discovery in lymphoid tissues by Steinman and Cohn, as cells with the unique ability to prime naïve antigen-specific T cells, it was realized that DC can exist in at least two distinctive states characterized by morphological, phenotypic and functional changes-this led to the description of DC maturation. It is now well appreciated that there are several subsets of DC in both lymphoid and non-lymphoid tissues of mammals, and these cells show remarkable functional specialization and specificity in their roles in tolerance and immunity. This review will focus on the specific characteristics of DC subsets and how their functional specialization may be regulated by distinctive gene expression programs and signaling responses in both steady-state and in the context of inflammation. In particular, we will highlight the common and distinctive genes and signaling pathways that are associated with the functional maturation of DC subsets. © 2014 The Authors.

  20. Repository-based software engineering program: Concept document

    Science.gov (United States)

    1992-01-01

    This document provides the context for Repository-Based Software Engineering's (RBSE's) evolving functional and operational product requirements, and it is the parent document for development of detailed technical and management plans. When furnished, requirements documents will serve as the governing RBSE product specification. The RBSE Program Management Plan will define resources, schedules, and technical and organizational approaches to fulfilling the goals and objectives of this concept. The purpose of this document is to provide a concise overview of RBSE, describe the rationale for the RBSE Program, and define a clear, common vision for RBSE team members and customers. The document also provides the foundation for developing RBSE user and system requirements and a corresponding Program Management Plan. The concept is used to express the program mission to RBSE users and managers and to provide an exhibit for community review.

  1. DNAM-1 Expression Marks an Alternative Program of NK Cell Maturation

    Directory of Open Access Journals (Sweden)

    Ludovic Martinet

    2015-04-01

    Full Text Available Natural killer (NK cells comprise a heterogeneous population of cells important for pathogen defense and cancer surveillance. However, the functional significance of this diversity is not fully understood. Here, we demonstrate through transcriptional profiling and functional studies that the activating receptor DNAM-1 (CD226 identifies two distinct NK cell functional subsets: DNAM-1+ and DNAM-1− NK cells. DNAM-1+ NK cells produce high levels of inflammatory cytokines, have enhanced interleukin 15 signaling, and proliferate vigorously. By contrast, DNAM-1− NK cells that differentiate from DNAM-1+ NK cells have greater expression of NK-cell-receptor-related genes and are higher producers of MIP1 chemokines. Collectively, our data reveal the existence of a functional program of NK cell maturation marked by DNAM-1 expression.

  2. Actively station: Effects on global cognition of mature adults and healthy elderly program using eletronic games

    Directory of Open Access Journals (Sweden)

    Tiago Nascimento Ordonez

    Full Text Available ABSTRACT Studies show that aging is accompanied by decline in cognitive functions but also indicate that interventions, such as training on electronic games, can enhance performance and promote maintenance of cognitive abilities in healthy older adults. Objective: To investigate the effects of an electronic game program, called Actively Station, on the performance of global cognition of adults aged over 50 years. Methods: 124 mature and elderly adults enrolled in the "Actively Station" cognitive stimulation program of São Caetano do Sul City, in the State of São Paulo, participated in training for learning of electronic games. Participants were divided into two groups: training group (TG n=102 and control group (CG n=22. Protocol: a sociodemographic questionnaire, the Mini-Mental State Examination (MMSE, the Addenbrooke's Cognitive Examination Revised (ACE-R, the Memory Complaint Questionnaire (MAC-Q, the scale of frequency of forgetfulness, the Geriatric Depression Scale (GDS-15, the Geriatric Anxiety Inventory (GAI, the Global Satisfaction with Life Scale, and two scales on learning in the training. Results: The cognitive performance of the TG improved significantly after the program, particularly in the domains of language and memory, and there was a decrease on the anxiety index and frequency of memory complaints, when compared to the CG. Conclusion: These findings suggest that the acquisition of new knowledge and the use of new stimuli, such as electronic games, can promote improvements in cognition and mood and reduce the frequency of memory complaints.

  3. National Waste Terminal Storage Program: critical element management concept. Volume II. Concept description

    International Nuclear Information System (INIS)

    1977-05-01

    The objective of the CEM Concept is to describe techniques for systematically identifying, evaluating, and influencing those technical, social, economic, political and institutional factors (i.e., events, trends and conditions) that are perceived as being probable uncertainties to the attainment of planned program objectives

  4. Advanced programming concepts in a course on grammars and parsing

    NARCIS (Netherlands)

    Jeuring, J.T.; Swierstra, S.D.

    1999-01-01

    One of the important goals of the Computer Science curriculum at Utrecht University is to familiarize students with abstract programming concepts such as, for example, partial evaluation and deforestation. A course on grammars and parsing offers excellent possibilities for exemplifying and

  5. An Analysis of Factors Affecting Mature Age Students' Academic Success in Undergraduate Nursing Programs: A Critical Literature Review.

    Science.gov (United States)

    Hayden, Lisa J; Jeong, Sarah Y; Norton, Carol A

    2016-01-01

    The population of mature age students entering university nursing programs has steadily increased in both Australia and worldwide. The objective of the literature review was to explore how mature age students perform academically and to analyse the factors associated with their academic performance in nursing programs. A literature search was conducted in the following databases: CINAHL, ProQuest, Medline, Cochrane, Mosby's Index, Joanna Briggs Institute (JBI), and Scopus. Twenty-six (26) research papers published between 2000 and 2014 have met the selection criteria of this review. The key themes identified include; 1) ambiguity in definition of mature age and academic success, 2) age and academic success, 3) intrinsic factors (life experiences, emotional intelligence, and motivation and volition), and 4) extrinsic factors (peer, academic and family support; and learning style, components of the modules and mode of delivery). Current literature provides evidence that mature age nursing students perform at a higher level within the methodological issues discussed in this paper. Future research is warranted to advance the understanding of the complex relationship between extrinsic and intrinsic factors of mature age students and their academic success in higher education. Nursing educators will benefit from novel evidence, ideas and opportunities to explore and implement in nursing education.

  6. Software engineering aspects of real-time programming concepts

    Science.gov (United States)

    Schoitsch, Erwin

    1986-08-01

    Real-time programming is a discipline of great importance not only in process control, but also in fields like communication, office automation, interactive databases, interactive graphics and operating systems development. General concepts of concurrent programming and constructs for process-synchronization are discussed in detail. Tasking and synchronization concepts, methods of process communication, interrupt and timeout handling in systems based on semaphores, signals, conditional critical regions or on real-time languages like Concurrent PASCAL, MODULA, CHILL and ADA are explained and compared with each other. The second part deals with structuring and modularization of technical processes to build reliable and maintainable real time systems. Software-quality and software engineering aspects are considered throughout the paper.

  7. Report on the Concept Review Committee recommendations for proof-of-principle alternate concept programs

    International Nuclear Information System (INIS)

    1979-03-01

    The report is organized as follows: Section II contains a discussion of the meeting procedures used on October 16--18, 1978, and the rules employed for technical consultants and advisors to the CRC. Section III contains a discussion of the CRC recommendations and some of the factors taken into consideration by the Committee. Section IV briefly discusses where do we go from here in DOE's alternate concepts program

  8. Strategic Approaches to Trading Science Objectives Against Measurements and Mission Design: Mission Architecture and Concept Maturation at the Jet Propulsion Laboratory

    Science.gov (United States)

    Case, K. E.; Nash, A. E., III

    2017-12-01

    Earth Science missions are increasingly challenged to improve our state of the art through more sophisticated hypotheses and inclusion of advanced technologies. However, science return needs to be constrained to the cost environment. Selectable mission concepts are the result of an overlapping Venn diagram of compelling science, feasible engineering solutions, and programmatic acceptable costs, regardless of whether the science investigation is Earth Venture or Decadal class. Since the last Earth Science and Applications Decadal Survey released in 2007, many new advanced technologies have emerged, in instrument, SmallSat flight systems, and launch service capabilities, enabling new mission architectures. These mission architectures may result in new thinking about how we achieve and collect science measurements, e.g., how to improve time-series measurements. We will describe how the JPL Formulation Office is structured to integrate methods, tools, and subject matter experts to span the mission concept development lifecycle, and assist Principal Investigators in maturing their mission ideas into realizable concepts.

  9. The histone demethylase Kdm6b regulates a mature gene expression program in differentiating cerebellar granule neurons.

    Science.gov (United States)

    Wijayatunge, Ranjula; Liu, Fang; Shpargel, Karl B; Wayne, Nicole J; Chan, Urann; Boua, Jane-Valeriane; Magnuson, Terry; West, Anne E

    2018-03-01

    The histone H3 lysine 27 (H3K27) demethylase Kdm6b (Jmjd3) can promote cellular differentiation, however its physiological functions in neurons remain to be fully determined. We studied the expression and function of Kdm6b in differentiating granule neurons of the developing postnatal mouse cerebellum. At postnatal day 7, Kdm6b is expressed throughout the layers of the developing cerebellar cortex, but its expression is upregulated in newborn cerebellar granule neurons (CGNs). Atoh1-Cre mediated conditional knockout of Kdm6b in CGN precursors either alone or in combination with Kdm6a did not disturb the gross morphological development of the cerebellum. Furthermore, RNAi-mediated knockdown of Kdm6b in cultured CGN precursors did not alter the induced expression of early neuronal marker genes upon cell cycle exit. By contrast, knockdown of Kdm6b significantly impaired the induction of a mature neuronal gene expression program, which includes gene products required for functional synapse maturation. Loss of Kdm6b also impaired the ability of Brain-Derived Neurotrophic Factor (BDNF) to induce expression of Grin2c and Tiam1 in maturing CGNs. Taken together, these data reveal a previously unknown role for Kdm6b in the postmitotic stages of CGN maturation and suggest that Kdm6b may work, at least in part, by a transcriptional mechanism that promotes gene sensitivity to regulation by BDNF. Copyright © 2017 Elsevier Inc. All rights reserved.

  10. The Lassen Astrobiology Intern Program - Concept, Implementation and Evaluation

    Science.gov (United States)

    Des Marais, D. J.; Dueck, S. L.; Davis, H. B.; Parenteau, M. N.; Kubo, M. D.

    2014-12-01

    The program goal was to provide a hands-on astrobiology learning experience to high school students by introducing astrobiology and providing opportunities to conduct field and lab research with NASA scientists. The program sought to increase interest in interdisciplinary science, technology, engineering, math and related careers. Lassen Volcanic National Park (LVNP), Red Bluff High School and the Ames Team of the NASA Astrobiology Institute led the program. LVNP was selected because it shares aspects of volcanism with Mars and it hosts thermal springs with microbial mat communities. Students documented volcanic deposits, springs and microbial mats. They analyzed waters and sampled rocks, water and microorganisms. They cultured microorganisms and studied chemical reactions between rocks and simulated spring waters. Each student prepared a report to present data and discuss relationships between volcanic rocks and gases, spring waters and microbial mats. At a "graduation" event the students presented their findings to the Red Bluff community. They visited Ames Research Center to tour the facilities and learn about science and technology careers. To evaluate program impact, surveys were given to students after lectures, labs, fieldwork and discussions with Ames scientists. Students' work was scored using rubrics (labs, progress reports, final report, presentation). Students took pre/post tests on core astrobiology concepts. Parents, teachers, rangers, Ames staff and students completed end-of-year surveys on program impact. Several outcomes were documented. Students had a unique and highly valued learning experience with NASA scientists. They understood what scientists do through authentic scientific work, and what scientists are like as individuals. Students became knowledgeable about astrobiology and how it can be pursued in the lab and in the field. The students' interest increased markedly in astrobiology, interdisciplinary studies and science generally.

  11. Paste pumping and deposition field trials and concepts on Syncrude's dewatered mature fine tailings MFT centrifuge cake

    Energy Technology Data Exchange (ETDEWEB)

    Lahaie, R. [Syncrude Canada Ltd., Edmonton, AB (Canada); Ahmed, I.; Labelle, M.; Brown, R. [Golder Paste Technology, Sudbury, ON (Canada)

    2009-07-01

    This presentation discussed a paste pumping and deposition field study conducted on dewatered mature fine tailings (MFT) located at Syncrude's Mildred Lake operation. Bench scale rheological examinations of centrifuge cakes and design field testing are used to determine the pumpability of MFT centrifuge cakes. The study included a transportation assessment for the conveyor and positive displacement pumps and pipelines, as well as geotechnical and environmental analyses of bulk materials. Flocculant optimization and centrifuge operational parameter assessments were conducted. Pressure differential and flow rate data were captured in the field studies in order to determine pipeline friction loss. The study showed that pipe friction factors can be obtained using the Bingham plastic model. A natural deposition angle was determined for the MFT centrifuged cake. The study showed that the cake must be sheared in order to reduce yield stress before pumping. It was concluded that displacement pumps can be used to reduced pipeline friction factors. tabs., figs.

  12. Developmental programming of long non-coding RNAs during postnatal liver maturation in mice.

    Directory of Open Access Journals (Sweden)

    Lai Peng

    Full Text Available The liver is a vital organ with critical functions in metabolism, protein synthesis, and immune defense. Most of the liver functions are not mature at birth and many changes happen during postnatal liver development. However, it is unclear what changes occur in liver after birth, at what developmental stages they occur, and how the developmental processes are regulated. Long non-coding RNAs (lncRNAs are involved in organ development and cell differentiation. Here, we analyzed the transcriptome of lncRNAs in mouse liver from perinatal (day -2 to adult (day 60 by RNA-Sequencing, with an attempt to understand the role of lncRNAs in liver maturation. We found around 15,000 genes expressed, including about 2,000 lncRNAs. Most lncRNAs were expressed at a lower level than coding RNAs. Both coding RNAs and lncRNAs displayed three major ontogenic patterns: enriched at neonatal, adolescent, or adult stages. Neighboring coding and non-coding RNAs showed the trend to exhibit highly correlated ontogenic expression patterns. Gene ontology (GO analysis revealed that some lncRNAs enriched at neonatal ages have their neighbor protein coding genes also enriched at neonatal ages and associated with cell proliferation, immune activation related processes, tissue organization pathways, and hematopoiesis; other lncRNAs enriched at adolescent ages have their neighbor protein coding genes associated with different metabolic processes. These data reveal significant functional transition during postnatal liver development and imply the potential importance of lncRNAs in liver maturation.

  13. An Application of Technological Maturity Assessment to ROKAF T-50 Aircraft Production Program

    National Research Council Canada - National Science Library

    Maeng, Honjae

    2005-01-01

    .... Finally the US GAO methodology assesses the production readiness of a program by examining the status of Statistical Process Quality Control (SPQC) procedures. This thesis also presents to the ROKAF decision maker an independent knowledge-based estimation of the ROKAF T-50 program by applying the US GAO methodology to the T-50 program.

  14. Advanced Concept Exploration for Fast Ignition Science Program, Final Report

    Energy Technology Data Exchange (ETDEWEB)

    Stephens, Richard Burnite [General Atomics; McLean, Harry M. [Lawrence Livermore National Laboratory; Theobald, Wolfgang [Laboratory for Laser Energetics; Akli, Kramer U. [The Ohio State University; Beg, Farhat N. [University of California, San Diego; Sentoku, Yasuhiko [University of Nevada, Reno; Schumacher, Douglass W. [The Ohio State University; Wei, Mingsheng [General Atomics

    2013-09-04

    The Fast Ignition (FI) Concept for Inertial Confinement Fusion (ICF) has the potential to provide a significant advance in the technical attractiveness of Inertial Fusion Energy reactors. FI differs from conventional “central hot spot” (CHS) target ignition by decoupling compression from heating: using a laser (or heavy ion beam or Z pinch) drive pulse (10’s of nanoseconds) to create a dense fuel and a second, much shorter (~10 picoseconds) high intensity pulse to ignite a small volume within the dense fuel. The physics of fast ignition process was the focus of our Advanced Concept Exploration (ACE) program. Ignition depends critically on two major issues involving Relativistic High Energy Density (RHED) physics: The laser-induced creation of fast electrons and their propagation in high-density plasmas. Our program has developed new experimental platforms, diagnostic packages, computer modeling analyses, and taken advantage of the increasing energy available at laser facilities to advance understanding of the fundamental physics underlying these issues. Our program had three thrust areas: • Understand the production and characteristics of fast electrons resulting from FI relevant laser-plasma interactions and their dependence on laser prepulse and laser pulse length. • Investigate the subsequent fast electron transport in solid and through hot (FI-relevant) plasmas. • Conduct and understand integrated core-heating experiments by comparison to simulations. Over the whole period of this project (three years for this contract), we have greatly advanced our fundamental understanding of the underlying properties in all three areas: • Comprehensive studies on fast electron source characteristics have shown that they are controlled by the laser intensity distribution and the topology and plasma density gradient. Laser pre-pulse induced pre-plasma in front of a solid surface results in increased stand-off distances from the electron origin to the high density

  15. Sense of Well-Being in Patients with Fibromyalgia: Aerobic Exercise Program in a Mature Forest—A Pilot Study

    Directory of Open Access Journals (Sweden)

    Secundino López-Pousa

    2015-01-01

    program consisting of walking through a mature forest can provide the subjective perception of having less days of pain and insomnia and more days of wellness, in patients with fibromyalgia.

  16. Methods for evaluating a mature substance abuse prevention/early intervention program.

    Science.gov (United States)

    Becker, L R; Hall, M; Fisher, D A; Miller, T R

    2000-05-01

    The authors describe methods for work in progress to evaluate four workplace prevention and/or early intervention programs designed to change occupational norms and reduce substance abuse at a major U.S. transportation company. The four programs are an employee assistance program, random drug testing, managed behavioral health care, and a peer-led intervention program. An elaborate mixed-methods evaluation combines data collection and analysis techniques from several traditions. A process-improvement evaluation focuses on the peer-led component to describe its evolution, document the implementation process for those interested in replicating it, and provide information for program improvement. An outcome-assessment evaluation examines impacts of the four programs on job performance measures (e.g., absenteeism, turnover, injury, and disability rates) and includes a cost-offset and employer cost-savings analysis. Issues related to using archival data, combining qualitative and quantitative designs, and working in a corporate environment are discussed.

  17. A mature industrial solution for ITER divertor plasma facing components: hypervapotron cooling concept adapted to Tore Supra flat tile technology

    Energy Technology Data Exchange (ETDEWEB)

    Escourbiac, F.; Missirlian, M.; Schlosser, J. [Association EURATOM-CEA Cadarache, Departement de Recherches sur la Fusion Controlee, 13 - Saint Paul lez Durance (France); Bobin-Vastra, I. [AREVA Centre Technique de Framatome, 71 - Le Creusot (France); Kuznetsov, V. [Efremov Institute, Doroga na Metallostroy, St. Petersburg (Russian Federation); Schedler, B. [Plansee AG, Reutte (Austria)

    2004-07-01

    The use of flat tile technology to handle heat fluxes in the range of 20 MW/m{sup 2} with components relevant for fusion experiment applications is technically possible with the hypervapotron cooling concept. This paper deals with recent high heat flux performances operated with success on 2 identical mock-ups, based on this concept, that were tested in 2 different electron gun facilities. Each mock-up consisted of a CuCrZr heat sink armored with 25 flat tiles of the 3D carbon fibre composite material SEPcarb NS31 assembled with pure copper by active metal casting (AMC). The AMC tiles were electron beam welded on the CuCrZr bar, fins and slots on the neutral beam JET design were machined into the bar, then the bar was closed with a thick CuCrZr rear plug including hydraulic connections then the bar was electron beam welded onto the sidewalls. The testing results show that full ITER design specifications were achieved with margins, the critical heat flux limit was even higher than 30 MW/m{sup 2}. These results highlight the high potential of this technology for ITER divertor application.

  18. A mature industrial solution for ITER divertor plasma facing components: hypervapotron cooling concept adapted to Tore Supra flat tile technology

    International Nuclear Information System (INIS)

    Escourbiac, F.; Missirlian, M.; Schlosser, J.; Bobin-Vastra, I.; Kuznetsov, V.; Schedler, B.

    2004-01-01

    The use of flat tile technology to handle heat fluxes in the range of 20 MW/m 2 with components relevant for fusion experiment applications is technically possible with the hypervapotron cooling concept. This paper deals with recent high heat flux performances operated with success on 2 identical mock-ups, based on this concept, that were tested in 2 different electron gun facilities. Each mock-up consisted of a CuCrZr heat sink armored with 25 flat tiles of the 3D carbon fibre composite material SEPcarb NS31 assembled with pure copper by active metal casting (AMC). The AMC tiles were electron beam welded on the CuCrZr bar, fins and slots on the neutral beam JET design were machined into the bar, then the bar was closed with a thick CuCrZr rear plug including hydraulic connections then the bar was electron beam welded onto the sidewalls. The testing results show that full ITER design specifications were achieved with margins, the critical heat flux limit was even higher than 30 MW/m 2 . These results highlight the high potential of this technology for ITER divertor application

  19. The restructured fusion program and the role of alternative fusion concepts

    International Nuclear Information System (INIS)

    Perkins, L.J.

    1996-01-01

    This testimony to the subcommittee on Energy and the Environment of the U.S. House of Representatives's Committee on Science pushes for about 25% of the fusion budget to go to alternative fusion concepts. These concepts are: low density magnetic confinement, inertial confinement fusion, high density magnetic confinement, and non- thermonuclear and miscellaneous programs. Various aspects of each of these concepts are outlined

  20. A Program to Enhance Self-Concept of Junior High Students.

    Science.gov (United States)

    McMillan, James H.

    This research analyzes the results of a program to enhance the self concepts of junior high students. Subjects were 80 students identified as having low self concepts. They participated in an eight-week program to develop skills in personal and social awareness. Pretest posttest scores on the Coopersmith Self-Esteem Inventory indicated that…

  1. The Effects of a Museum Art Program on the Self-Concept of Children

    Science.gov (United States)

    Kaufman, Ryan; Rinehardt, Eric; Hine, Hank; Wilkinson, Berney; Tush, Peter; Mead, Bethany; Fernandez, Francisco

    2014-01-01

    Research suggests that art programs have positive therapeutic effects on children, including improved self-concept. This pretest/posttest intervention study examined changes in self-concept in children (N = 176) who participated in an art program at the Dalí Museum in St. Petersburg, Florida. Results indicated significant, positive increases in…

  2. LOGO programming contents for supporting mathematical concept development : promotion of the verbalization and imaging of figure concepts

    OpenAIRE

    杉野, 裕子

    2014-01-01

    I have been studying to show the importance of adopting a programming in the mathematical education and developed the LOGO teaching materials which is made good use of in the field of Euclidean geometry, in order to improve understanding and learning figure concepts. The present article offers a theoretical framework with consistency about my study and also new programming materials in which I embody my theory. I consider logically the system of mathematical expression with computers and espe...

  3. Gene expression programs during Brassica oleracea seed maturation, osmopriming and germination process and the stress tolerance level

    NARCIS (Netherlands)

    Soeda, Y.; Konings, M.C.J.M.; Vorst, O.F.J.; Houwelingen, van A.M.M.L.; Stoopen, G.M.; Maliepaard, C.A.; Kodde, J.; Bino, R.J.; Groot, S.P.C.; Geest, van der A.H.M.

    2005-01-01

    During seed maturation and germination, major changes in physiological status, gene expression, and metabolic events take place. Using chlorophyll sorting, osmopriming, and different drying regimes, Brassica oleracea seed lots of different maturity, stress tolerance, and germination behavior were

  4. Maturity and maturity models in lean construction

    Directory of Open Access Journals (Sweden)

    Claus Nesensohn

    2014-03-01

    Full Text Available In recent years there has been an increasing interest in maturity models in management-related disciplines; which reflects a growing recognition that becoming more mature and having a model to guide the route to maturity can help organisations in managing major transformational change. Lean Construction (LC is an increasingly important improvement approach that organisations seek to embed. This study explores how to apply the maturity models to LC. Hence the attitudes, opinions and experiences of key industry informants with high levels of knowledge of LC were investigated. To achieve this, a review of maturity models was conducted, and data for the analysis was collected through a sequential process involving three methods. First a group interview with seven key informants. Second a follow up discussion with the same individuals to investigate some of the issues raised in more depth. Third an online discussion held via LinkedIn in which members shared their views on some of the results. Overall, we found that there is a lack of common understanding as to what maturity means in LC, though there is general agreement that the concept of maturity is a suitable one to reflect the path of evolution for LC within organisations.

  5. Concept document of the repository-based software engineering program: A constructive appraisal

    Science.gov (United States)

    1992-01-01

    A constructive appraisal of the Concept Document of the Repository-Based Software Engineering Program is provided. The Concept Document is designed to provide an overview of the Repository-Based Software Engineering (RBSE) Program. The Document should be brief and provide the context for reading subsequent requirements and product specifications. That is, all requirements to be developed should be traceable to the Concept Document. Applied Expertise's analysis of the Document was directed toward assuring that: (1) the Executive Summary provides a clear, concise, and comprehensive overview of the Concept (rewrite as necessary); (2) the sections of the Document make best use of the NASA 'Data Item Description' for concept documents; (3) the information contained in the Document provides a foundation for subsequent requirements; and (4) the document adequately: identifies the problem being addressed; articulates RBSE's specific role; specifies the unique aspects of the program; and identifies the nature and extent of the program's users.

  6. The marketing concept applied to an education program.

    Science.gov (United States)

    Parks, S C; Moody, D L; Barbrow, E P

    1984-09-01

    Dietetic education programs seeking to maintain their enrollment levels may find it necessary to adopt more sophisticated marketing strategies. This article describes the application of the marketing process to an extended degree dietetic program that serves a national audience. It also presents a strategy for initiating a marketing study and marketing orientation by analyzing its internal program data. The article discusses the specific market characteristics of the program's primary market segments, and it presents further implications for dietitians at work in health care facilities, in businesses, or in private practice.

  7. Compassion and Caring: Missing Concepts in Social Studies Programs.

    Science.gov (United States)

    Oliner, Pearl

    1979-01-01

    Current social studies programs do not include the study of prosocial behaviors such as altruism, generosity, and compassion. This omission legitimizes the view that human behaviors are self-serving. Curriculum developers should fashion programs which provide prosocial models and opportunities for students to conceptualize such behaviors and…

  8. Java vs. Python Coverage of Introductory Programming Concepts: A Textbook Analysis

    Science.gov (United States)

    McMaster, Kirby; Sambasivam, Samuel; Rague, Brian; Wolthuis, Stuart

    2017-01-01

    In this research, we compare two languages, Java and Python, by performing a content analysis of words in textbooks that describe important programming concepts. Our goal is to determine which language has better textbook support for teaching introductory programming courses. We used the TextSTAT program to count how often our list of concept…

  9. A CONCEPT OF SOFTWARE SUPPORT OF LEARNING PROGRAMMING LANGUAGE AND TECHNOLOGIES

    Directory of Open Access Journals (Sweden)

    V. Kruglyk

    2013-03-01

    Full Text Available A concept of software support of learning programming language and technologies is regarded in the article. Present systems of independent study of subjects, related to programming, are examined. Necessary components of a system of support learning programming languages and technologies, which is oriented on independent study, are considered.

  10. ISTC: experimental and technology programs toward novel reactor concepts (review of the ISTC projects and programs)

    Energy Technology Data Exchange (ETDEWEB)

    Tocheny, L.V. [ISTC - International Science and Technology Center, Moscow, Russia, Moscow (Russian Federation)

    2007-07-01

    The ISTC (International Science and Technology Center) is a unique international organization created in Moscow more than twelve years ago by Russia, Usa, E.U. and Japan. Later Korea and Canada, and several CIS countries as well acceded to ISTC. The basic idea behind establishing the ISTC was to support non-proliferation of the mass destruction weapons technologies by re-directing former Soviet weapons scientists to peaceful research thus preventing the drain of dangerous knowledge and expertise from Russia and other CIS countries. Numerous science and technology projects were realized with the ISTC support in different areas, from bio-technologies and environmental problems to all aspects of nuclear studies, including those focused on the development of effective innovative concepts and technologies in the nuclear field, in general, and for improvement of nuclear safety, in particular. The presentation addresses some technical results of the ISTC projects as well as methods and approaches employed by the ISTC to foster close international collaboration and manage projects towards fruitful results. Goals of this presentation are to introduce some of the ISTC programs to international nuclear community to give examples of international cooperation, created in the frames of ISTC, to illustrate the statement of importance of international nuclear experiment as a tool for evidence of new nuclear concepts acceptance, and to make a call for further joint collaboration. (author)

  11. ISTC: experimental and technology programs toward novel reactor concepts (review of the ISTC projects and programs)

    International Nuclear Information System (INIS)

    Tocheny, L.V.

    2007-01-01

    The ISTC (International Science and Technology Center) is a unique international organization created in Moscow more than twelve years ago by Russia, Usa, E.U. and Japan. Later Korea and Canada, and several CIS countries as well acceded to ISTC. The basic idea behind establishing the ISTC was to support non-proliferation of the mass destruction weapons technologies by re-directing former Soviet weapons scientists to peaceful research thus preventing the drain of dangerous knowledge and expertise from Russia and other CIS countries. Numerous science and technology projects were realized with the ISTC support in different areas, from bio-technologies and environmental problems to all aspects of nuclear studies, including those focused on the development of effective innovative concepts and technologies in the nuclear field, in general, and for improvement of nuclear safety, in particular. The presentation addresses some technical results of the ISTC projects as well as methods and approaches employed by the ISTC to foster close international collaboration and manage projects towards fruitful results. Goals of this presentation are to introduce some of the ISTC programs to international nuclear community to give examples of international cooperation, created in the frames of ISTC, to illustrate the statement of importance of international nuclear experiment as a tool for evidence of new nuclear concepts acceptance, and to make a call for further joint collaboration. (author)

  12. A concept for a bachelor program in electrical engineering

    DEFF Research Database (Denmark)

    Niemann, Hans Henrik

    2011-01-01

    The main concept for the Bachelor of Science in Engineering (BScE) in electrical engineering at Technical University of Denmark (DTU) will be described in this paper. A new curriculum was introduced from the start of the autumn semester in 2010. The curriculum was the result of more than one year...... of work with first description of competences followed by a more detailed description of the single main areas. Finally, the new study plan was implemented through a number of courses satisfying some general rules for bachelor study plans.......The main concept for the Bachelor of Science in Engineering (BScE) in electrical engineering at Technical University of Denmark (DTU) will be described in this paper. A new curriculum was introduced from the start of the autumn semester in 2010. The curriculum was the result of more than one year...

  13. OSU TOMF Program Site Selection and Preliminary Concept Design Report

    Energy Technology Data Exchange (ETDEWEB)

    Spadling, Steve [Oklahoma State Univ., Stillwater, OK (United States)

    2012-05-10

    The purpose of this report is to confirm the programmatic requirements for the new facilities, identify the most appropriate project site, and develop preliminary site and building concepts that successfully address the overall project goals and site issues. These new facilities will be designed to accommodate the staff, drivers and maintenance requirements for the future mixed fleet of passenger vehicles, Transit Style Buses and School Buses.

  14. Seed maturation associated transcriptional programs and regulatory networks underlying genotypic difference in seed dormancy and size/weight in wheat (Triticum aestivum L.).

    Science.gov (United States)

    Yamasaki, Yuji; Gao, Feng; Jordan, Mark C; Ayele, Belay T

    2017-09-16

    Maturation forms one of the critical seed developmental phases and it is characterized mainly by programmed cell death, dormancy and desiccation, however, the transcriptional programs and regulatory networks underlying acquisition of dormancy and deposition of storage reserves during the maturation phase of seed development are poorly understood in wheat. The present study performed comparative spatiotemporal transcriptomic analysis of seed maturation in two wheat genotypes with contrasting seed weight/size and dormancy phenotype. The embryo and endosperm tissues of maturing seeds appeared to exhibit genotype-specific temporal shifts in gene expression profile that might contribute to the seed phenotypic variations. Functional annotations of gene clusters suggest that the two tissues exhibit distinct but genotypically overlapping molecular functions. Motif enrichment predicts genotypically distinct abscisic acid (ABA) and gibberellin (GA) regulated transcriptional networks contribute to the contrasting seed weight/size and dormancy phenotypes between the two genotypes. While other ABA responsive element (ABRE) motifs are enriched in both genotypes, the prevalence of G-box-like motif specifically in tissues of the dormant genotype suggests distinct ABA mediated transcriptional mechanisms control the establishment of dormancy during seed maturation. In agreement with this, the bZIP transcription factors that co-express with ABRE enriched embryonic genes differ with genotype. The enrichment of SITEIIATCYTC motif specifically in embryo clusters of maturing seeds irrespective of genotype predicts a tissue specific role for the respective TCP transcription factors with no or minimal contribution to the variations in seed dormancy. The results of this study advance our understanding of the seed maturation associated molecular mechanisms underlying variation in dormancy and weight/size in wheat seeds, which is a critical step towards the designing of molecular strategies

  15. Artist concept of Mercury program study of medical effects and technology

    Science.gov (United States)

    1964-01-01

    Artist concept of Mercury program study of medical effects and technology development. Drawing depicts cut-away view of Mercury capsule orbiting the Earth, showing the astronaut and his capsule's hardware.

  16. Structural Equation Modeling with Mplus Basic Concepts, Applications, and Programming

    CERN Document Server

    Byrne, Barbara M

    2011-01-01

    Modeled after Barbara Byrne's other best-selling structural equation modeling (SEM) books, this practical guide reviews the basic concepts and applications of SEM using Mplus Versions 5 & 6. The author reviews SEM applications based on actual data taken from her own research. Using non-mathematical language, it is written for the novice SEM user. With each application chapter, the author "walks" the reader through all steps involved in testing the SEM model including: an explanation of the issues addressed illustrated and annotated testing of the hypothesized and post hoc models expl

  17. Conceptions of Teaching Science Held by Novice Teachers in an Alternative Certification Program

    Science.gov (United States)

    Koballa, Thomas R.; Glynn, Shawn M.; Upson, Leslie

    2005-01-01

    Case studies to investigate the conceptions of teaching science held by three novice teachers participating in an alternative secondary science teacher certification program were conducted, along with the relationships between their conceptions of science teaching and their science teaching practice. Data used to build the cases included the…

  18. Recognizing and Managing Complexity: Teaching Advanced Programming Concepts and Techniques Using the Zebra Puzzle

    OpenAIRE

    Xihui "Paul" Zhang; John D. Crabtree

    2015-01-01

    Teaching advanced programming can be a challenge, especially when the students are pursuing different majors with diverse analytical and problem-solving capabilities. The purpose of this paper is to explore the efficacy of using a particular problem as a vehicle for imparting a broad set of programming concepts and problem-solving techniques. We present a classic brain teaser that is used to communicate and demonstrate advanced software development concepts and techniques. Our results show th...

  19. The Java Series: Basic Concepts in Object Oriented Programming

    CERN Multimedia

    CERN. Geneva

    2000-01-01

    The talk will be general enough not to require any previous knowledge of any programming language but some insight in software development would be convenient. In the same way, the talk will give you the basics to learn any OO based methodology or language.

  20. A concept for performance management for Federal science programs

    Science.gov (United States)

    Whalen, Kevin G.

    2017-11-06

    The demonstration of clear linkages between planning, funding, outcomes, and performance management has created unique challenges for U.S. Federal science programs. An approach is presented here that characterizes science program strategic objectives by one of five “activity types”: (1) knowledge discovery, (2) knowledge development and delivery, (3) science support, (4) inventory and monitoring, and (5) knowledge synthesis and assessment. The activity types relate to performance measurement tools for tracking outcomes of research funded under the objective. The result is a multi-time scale, integrated performance measure that tracks individual performance metrics synthetically while also measuring progress toward long-term outcomes. Tracking performance on individual metrics provides explicit linkages to root causes of potentially suboptimal performance and captures both internal and external program drivers, such as customer relations and science support for managers. Functionally connecting strategic planning objectives with performance measurement tools is a practical approach for publicly funded science agencies that links planning, outcomes, and performance management—an enterprise that has created unique challenges for public-sector research and development programs.

  1. Assessment of High Rates of Precocious Male Maturation in a Spring Chinook Salmon Supplementation Hatchery Program, Annual Report 2002-2003.

    Energy Technology Data Exchange (ETDEWEB)

    Larsen, Donald; Beckman, Brian; Cooper, Kathleen

    2003-08-01

    The Yakima River Spring Chinook Salmon Supplementation Project in Washington State is currently one of the most ambitious efforts to enhance a natural salmon population in the United States. Over the past five years we have conducted research to characterize the developmental physiology of naturally- and hatchery-reared wild progeny spring chinook salmon (Oncorhynchus tshawytscha) in the Yakima River basin. Fish were sampled at the main hatchery in Cle Elum, at remote acclimation sites and, during smolt migration, at downstream dams. Throughout these studies the maturational state of all fish was characterized using combinations of visual and histological analysis of testes, gonadosomatic index (GSI), and measurement of plasma 11-ketotestosterone (11-KT). We established that a plasma 11-KT threshold of 0.8 ng/ml could be used to designate male fish as either immature or precociously maturing approximately 8 months prior to final maturation (1-2 months prior to release as 'smolts'). Our analyses revealed that 37-49% of the hatchery-reared males from this program undergo precocious maturation at 2 years of age and a proportion of these fish appear to residualize in the upper Yakima River basin throughout the summer. An unnaturally high incidence of precocious male maturation may result in loss of potential returning anadromous adults, skewing of female: male sex ratios, ecological, and genetic impacts on wild populations and other native species. Precocious male maturation is significantly influenced by growth rate at specific times of year and future studies will be conducted to alter maturation rates through seasonal growth rate manipulations.

  2. Structural equation modeling with EQS basic concepts, applications, and programming

    CERN Document Server

    Byrne, Barbara M

    2013-01-01

    Readers who want a less mathematical alternative to the EQS manual will find exactly what they're looking for in this practical text. Written specifically for those with little to no knowledge of structural equation modeling (SEM) or EQS, the author's goal is to provide a non-mathematical introduction to the basic concepts of SEM by applying these principles to EQS, Version 6.1. The book clearly demonstrates a wide variety of SEM/EQS applications that include confirmatory factor analytic and full latent variable models. Written in a "user-friendly" style, the author "walks" the reader through the varied steps involved in the process of testing SEM models: model specification and estimation, assessment of model fit, EQS output, and interpretation of findings. Each of the book's applications is accompanied by: a statement of the hypothesis being tested, a schematic representation of the model, explanations of the EQS input and output files, tips on how to use the pull-down menus, and the data file upon which ...

  3. Zero-gravity cloud physics laboratory: Experiment program definition and preliminary laboratory concept studies

    Science.gov (United States)

    Eaton, L. R.; Greco, E. V.

    1973-01-01

    The experiment program definition and preliminary laboratory concept studies on the zero G cloud physics laboratory are reported. This program involves the definition and development of an atmospheric cloud physics laboratory and the selection and delineations of a set of candidate experiments that must utilize the unique environment of zero gravity or near zero gravity.

  4. Recognizing and Managing Complexity: Teaching Advanced Programming Concepts and Techniques Using the Zebra Puzzle

    Science.gov (United States)

    Crabtree, John; Zhang, Xihui

    2015-01-01

    Teaching advanced programming can be a challenge, especially when the students are pursuing different majors with diverse analytical and problem-solving capabilities. The purpose of this paper is to explore the efficacy of using a particular problem as a vehicle for imparting a broad set of programming concepts and problem-solving techniques. We…

  5. Ethics Education Seen through the Lens of Habermas's Conception of Practical Reason: The Quebec Education Program

    Science.gov (United States)

    Bouchard, Nancy; Morris, Ronald W.

    2012-01-01

    This paper examines the Quebec Education Program (QEP), particularly the new course in ethics and religious culture (ERC), in the light of Habermas's conception of the moral and ethical uses of practical reason. Habermas's discursive theory of morality is used to assess the program's understanding of what it means to be competent in moral matters.…

  6. Pre-Service Music Teachers' Metaphorical Perceptions of the Concept of a Music Teaching Program

    Science.gov (United States)

    Kiliç, Deniz Beste Çevik

    2017-01-01

    This study was intended to reveal pre-service music teachers' perceptions of the concept of a "music teaching program" with the use of metaphors. Its sample included 130 pre-service music teachers in the Music Teaching Program of Fine Arts Teaching Department in Balikesir University's Education Faculty. The study data were collected by…

  7. Civilian Power Program. Part 1, Summary, Current status of reactor concepts

    Energy Technology Data Exchange (ETDEWEB)

    Author, Not Given

    1959-09-01

    This study group covered the following: delineation of the specific objectives of the overall US AEC civilian power reactor program, technical objectives of each reactor concept, preparation of a chronological development program for each reactor concept, evaluation of the economic potential of each reactor type, a program to encourage the the development, and yardsticks for measuring the development. Results were used for policy review by AEC, program direction, authorization and appropriation requests, etc. This evaluation encompassed civilian power reactors rated at 25 MW(e) or larger and related experimental facilities and R&D. This Part I summarizes the significant results of the comprehensive effort to determine the current technical and economic status for each reactor concept; it is based on the 8 individual technical status reports (Part III).

  8. Maturity of the PWR

    International Nuclear Information System (INIS)

    Bacher, P.; Rapin, M.; Aboudarham, L.; Bitsch, D.

    1983-03-01

    Figures illustrating the predominant position of the PWR system are presented. The question is whether on the basis of these figures the PWR can be considered to have reached maturity. The following analysis, based on the French program experience, is an attempt to pinpoint those areas in which industrial maturity of the PWR has been attained, and in which areas a certain evolution can still be expected to take place

  9. Moving towards maturity in business model definitions

    DEFF Research Database (Denmark)

    Nielsen, Christian; Lund, Morten; Bukh, Per Nikolaj

    2014-01-01

    The field of business models has, as is the case with all emerging fields of practice, slowly matured through the development of frameworks, models, concepts and ideas over the last 15 years. New concepts, theories and models typically transcend a series of maturity phases. For the concept of Bus...

  10. Program assessment report, statement of findings. Satellite power systems concept development and evaluation program

    Energy Technology Data Exchange (ETDEWEB)

    None

    1980-11-01

    What is known, uncertain, and unknown about the Solar Power Satellite (SPS) concept is stated. The important technical, environmental, and cost goal questions that must be answered prior to making a commitment to the SPS concept are discussed. Although significant technological, environmental and economic questions remain to be answered, the preliminary investigations undertaken in the CDEP do provide a basis for a policy decision on further commitment. Also, areas of research and experimentation required to acquire the knowledge by which a series of informed, time-phased decisions may be made concerning the possibility of the SPS concept playing a major role in the United States' energy future are suggested.

  11. Teaching Basic Programming Concepts to Young Primary School Students Using Tablets: Results of a Pilot Project

    Science.gov (United States)

    Fokides, Emmanuel

    2018-01-01

    The study presents the results of a project in which tablets and a ready-made application were used for teaching basic programming concepts to young primary school students (ages 7-9). A total of 135 students participated in the study, attending primary schools in Athens, Greece, divided into three groups. The first was taught conventionally. The…

  12. The Use of Engineering Design Concept for Computer Programming Course: A Model of Blended Learning Environment

    Science.gov (United States)

    Tritrakan, Kasame; Kidrakarn, Pachoen; Asanok, Manit

    2016-01-01

    The aim of this research is to develop a learning model which blends factors from learning environment and engineering design concept for learning in computer programming course. The usage of the model was also analyzed. This study presents the design, implementation, and evaluation of the model. The research methodology is divided into three…

  13. A Model for Infusing Energy Concepts into Vocational Education Programs. Solar Energy Curriculum Guide.

    Science.gov (United States)

    Delta Vocational Technical School, Marked Tree, AR.

    This solar energy curriculum guide is designed to assist teachers in infusing energy concepts into vocational education programs. It consists of 31 competency-based instructional units organized into 10 sections. Covered in the sections are the following topics: related instructions (history and development; human relations; general safety;…

  14. Using Technology To Bring Abstract Concepts into Focus: A Programming Case Study.

    Science.gov (United States)

    Crews, Thad; Butterfield, Jeff

    2002-01-01

    Discusses the three-step implementation of an instructional technology tool and associated pedagogy to support teaching and learning computer programming concepts. The Flowchart Interpreter (FLINT) was proven through experiments to support novice programmers better than the traditional textbook approach. (EV)

  15. AICD -- Advanced Industrial Concepts Division Biological and Chemical Technologies Research Program. 1993 Annual summary report

    Energy Technology Data Exchange (ETDEWEB)

    Petersen, G.; Bair, K.; Ross, J. [eds.

    1994-03-01

    The annual summary report presents the fiscal year (FY) 1993 research activities and accomplishments for the United States Department of Energy (DOE) Biological and Chemical Technologies Research (BCTR) Program of the Advanced Industrial Concepts Division (AICD). This AICD program resides within the Office of Industrial Technologies (OIT) of the Office of Energy Efficiency and Renewable Energy (EE). The annual summary report for 1993 (ASR 93) contains the following: A program description (including BCTR program mission statement, historical background, relevance, goals and objectives), program structure and organization, selected technical and programmatic highlights for 1993, detailed descriptions of individual projects, a listing of program output, including a bibliography of published work, patents, and awards arising from work supported by BCTR.

  16. Recognizing and Managing Complexity: Teaching Advanced Programming Concepts and Techniques Using the Zebra Puzzle

    Directory of Open Access Journals (Sweden)

    Xihui "Paul" Zhang

    2015-06-01

    Full Text Available Teaching advanced programming can be a challenge, especially when the students are pursuing different majors with diverse analytical and problem-solving capabilities. The purpose of this paper is to explore the efficacy of using a particular problem as a vehicle for imparting a broad set of programming concepts and problem-solving techniques. We present a classic brain teaser that is used to communicate and demonstrate advanced software development concepts and techniques. Our results show that students with varied academic experiences and goals, assuming at least one procedural/structured programming pre-requisite, can benefit from and also be challenged by such an exercise. Although this problem has been used by others in the classroom, we believe that our use of this problem in imparting such a broad range of topics to a diverse student population is unique.

  17. Sense of Well-Being in Patients with Fibromyalgia: Aerobic Exercise Program in a Mature Forest A Pilot Study

    OpenAIRE

    López-Pousa, Secundino; Bassets Pagès, Glòria; Monserrat-Vila, Sílvia; Gracia Blanco, Manuel de; Hidalgo Colomé, Jaume; Garre-Olmo, Josep

    2015-01-01

    Background and Objective. Most patients with fibromyalgia benefit from different forms of physical exercise. Studies show that exercise can help restore the body's neurochemical balance and that it triggers a positive emotional state. So, regular exercise can help reduce anxiety, stress, and depression. The aim of this study was to analyze the benefits of moderate aerobic exercise when walking in two types of forests, young and mature, and to assess anxiety, sleep, pain, and well-being in pat...

  18. Comparing routine neurorehabilitation program with trunk exercises based on Bobath concept in multiple sclerosis: pilot study.

    Science.gov (United States)

    Keser, Ilke; Kirdi, Nuray; Meric, Aydin; Kurne, Asli Tuncer; Karabudak, Rana

    2013-01-01

    This study compared trunk exercises based on the Bobath concept with routine neurorehabilitation approaches in multiple sclerosis (MS). Bobath and routine neurorehabilitation exercises groups were evaluated. MS cases were divided into two groups. Both groups joined a 3 d/wk rehabilitation program for 8 wk. The experimental group performed trunk exercises based on the Bobath concept, and the control group performed routine neurorehabilitation exercises. Additionally, both groups performed balance and coordination exercises. All patients were evaluated with the Trunk Impairment Scale (TIS), Berg Balance Scale (BBS), International Cooperative Ataxia Rating Scale (ICARS), and Multiple Sclerosis Functional Composite (MSFC) before and after the physiotherapy program. In group analysis, TIS, BBS, ICARS, and MSFC scores and strength of abdominal muscles were significantly different after treatment in both groups (p 0.05). Although trunk exercises based on the Bobath concept are rarely applied in MS rehabilitation, the results of this study show that they are as effective as routine neurorehabilitation exercises. Therefore, trunk exercises based on the Bobath concept can be beneficial in MS rehabilitation programs.

  19. Maturity Models

    DEFF Research Database (Denmark)

    Lasrado, Lester Allan; Vatrapu, Ravi

    2016-01-01

    Recent advancements in set theory and readily available software have enabled social science researchers to bridge the variable-centered quantitative and case-based qualitative methodological paradigms in order to analyze multi-dimensional associations beyond the linearity assumptions, aggregate...... effects, unicausal reduction, and case specificity. Based on the developments in set theoretical thinking in social sciences and employing methods like Qualitative Comparative Analysis (QCA), Necessary Condition Analysis (NCA), and set visualization techniques, in this position paper, we propose...... and demonstrate a new approach to maturity models in the domain of Information Systems. This position paper describes the set-theoretical approach to maturity models, presents current results and outlines future research work....

  20. Satellite power system concept development and evaluation program system definition technical assessment report

    Energy Technology Data Exchange (ETDEWEB)

    1980-12-01

    The results of the system definition studies conducted by NASA as a part of the Department of Energy/National Aeronautics and Space Administration SPS Concept Development and Evaluation Program are summarized. The purpose of the system definition efforts was to identify and define candidate SPS concepts and to evaluate the concepts in terms of technical and cost factors. Although the system definition efforts consisted primarily of evaluation and assessment of alternative technical approaches, a reference system was also defined to facilitate economic, environmental, and societal assessments by the Department of Energy. This reference system was designed to deliver 5 GW of electrical power to the utility grid. Topics covered include system definition; energy conversion and power management; power transmission and reception; structures, controls, and materials; construction and operations; and space transportation.

  1. Clerkship maturity: does the idea of training clinical skills work?

    Science.gov (United States)

    Stosch, Christoph; Joachim, Alexander; Ascher, Johannes

    2011-01-01

    With the reformed curriculum "4C", the Medical Faculty of the University of Cologne has started to systematically plan practical skills training, for which Clerkship Maturity is the first step. The key guidelines along which the curriculum was development were developed by experts. This approach has now been validated. Both students and teachers were asked to fill in a questionnaire regarding preclinical practical skills training to confirm the concept of Clerkship Maturity. The Cologne training program Clerkship Maturity can be validated empirically overall through the activities of the students awaiting the clerkship framework and through the evaluation by the medical staff providing the training. The subjective ratings of the advantages of the training by the students leave room for improvement. Apart from minor improvements to the program, the most likely solution providing sustainable results will involve an over-regional strategy for establishing skills training planned as part of the curriculum.

  2. The Transition and Adoption to Modern Programming Concepts for Scientific Computing in Fortran

    Directory of Open Access Journals (Sweden)

    Charles D. Norton

    2007-01-01

    Full Text Available This paper describes our experiences in the early exploration of modern concepts introduced in Fortran90 for large-scale scientific programming. We review our early work in expressing object-oriented concepts based on the new Fortran90 constructs – foreign to most programmers at the time – our experimental work in applying them to various applications, the impact on the WG5/J3 standards committees to consider formalizing object-oriented constructs for later versions of Fortran, and work in exploring how other modern programming techniques such as Design Patterns can and have impacted our software development. Applications will be drawn from plasma particle simulation and finite element adaptive mesh refinement for solid earth crustal deformation modeling.

  3. Program for Plasma-Based Concepts for Future High Energy Accelerators

    International Nuclear Information System (INIS)

    Katsouleas, Thomas C.; Muggli, Patric

    2003-01-01

    OAK B204 Program for Plasma-Based Concepts for Future High Energy Accelerators. The progress made under this program in the period since November 15, 2002 is reflected in this report. The main activities for this period were to conduct the first run of the E-164 high-gradient wakefield experiment at SLAC, to prepare for run 2 and to continue our collaborative effort with CERN to model electron cloud interactions in circular accelerators. Each of these is described. Also attached to this report are papers that were prepared or appeared during this period

  4. Reactor physical experimental program EROS in the frame of the molten salt applying reactor concepts development

    International Nuclear Information System (INIS)

    Hron, Miloslav; Kyncl, Jan; Mikisek, Miroslav

    2009-01-01

    After the relatively broad program of experimental activities, which have been involved in the complex R and D program for the Molten Salt Reactor (MSR) - SPHINX (SPent Hot fuel Incinerator by Neutron fluX) concept development in the Czech Republic, there has been a next stage (namely large-scale experimental verification of design inputs by use of MSR-type inserted zones into the existing light water moderated experimental reactor LR-0 called EROS project) started, which will be focused to the experimental verification of the rector physical or neutronic properties of other types of reactor concepts applying molten salts in the role of liquid fuel and/or coolant. This tendency is based on the recently accepted decision of the MSR SSC of GIF to consider for further period of its activity two baseline concepts- fast neutron molten salt reactor non-moderated (FMSR-NM) as a long-term alternative to solid fuelled fast neutron reactors and simultaneously, advanced high temperature reactor (AHTR) with pebble bed type solid fuel cooled by liquid salts. There will be a brief description of the prepared and performed experimental programs in these directions (as well as the preliminary results obtained so far) introduced in the paper. (author)

  5. Review of the Commission program for standardization of nuclear power plants and recommendations to improve standardization concepts

    International Nuclear Information System (INIS)

    1978-02-01

    This is a report of a staff study describing the need and utility of specific changes to the Commission's standardization program. The various matters considered in the study include: (1) A discussion of industry use to date of the standardization program. (2) A discussion of the experience to date with each of the standardization concepts. (3) A review of public comments on the standardization program and the staff response to each principal comment. (4) A review of the need for standardization considering the likely number of license applications to be submitted in the coming years. (5) A discussion of the reference system concept, including review of applicable experience and recommended changes to the concept. (6) A discussion of the duplicate plant concept, including review of applicable experience and recommended changes to the concept. (7) A discussion of the manufacturing license concept, including review of applicable experience and recommended changes to the concept. (8) A discussion of the replicate plant concept, including review of applicable experience and recommended changes to the concept. (9) A discussion of the effective periods for approved designs under all four standardization concepts. (10) A description of continuing staff activities related to the standardization program

  6. Formative evaluation of an adaptive game for engaging learners of programming concepts in K-12

    Directory of Open Access Journals (Sweden)

    Renny S. N. Lindberg

    2018-06-01

    Full Text Available As the global demand for programmers is soaring, several countries have integrated programming into their K-12 curricula. Finding effective ways to engage children in programming education is an important objective. One effective method for this can be presenting learning materials via games, which are known to increase engagement and motivation. Current programming education games often focus on a single genre and offer one-size-fits-all experience to heterogeneous learners. In this study, we presented Minerva, a multi-genre (adventure, action, puzzle game to engage elementary school students in learning programming concepts. The game content is adapted to play and learning styles of the player to personalize the gameplay. We conducted a formative mixed-method evaluation of Minerva with 32 Korean 6th grade students who played the game and compared their learning outcomes with 32 6th grade students who studied the same concepts using handouts. The results indicated that, in terms of retention, learning was equally effective in both groups. Furthermore, the game was shown to facilitate engagement among the students. These results, together with uncovered issues, will guide Minerva’s further development.

  7. New verifiable stationarity concepts for a class of mathematical programs with disjunctive constraints.

    Science.gov (United States)

    Benko, Matúš; Gfrerer, Helmut

    2018-01-01

    In this paper, we consider a sufficiently broad class of non-linear mathematical programs with disjunctive constraints, which, e.g. include mathematical programs with complemetarity/vanishing constraints. We present an extension of the concept of [Formula: see text]-stationarity which can be easily combined with the well-known notion of M-stationarity to obtain the stronger property of so-called [Formula: see text]-stationarity. We show how the property of [Formula: see text]-stationarity (and thus also of M-stationarity) can be efficiently verified for the considered problem class by computing [Formula: see text]-stationary solutions of a certain quadratic program. We consider further the situation that the point which is to be tested for [Formula: see text]-stationarity, is not known exactly, but is approximated by some convergent sequence, as it is usually the case when applying some numerical method.

  8. A study of concept-based similarity approaches for recommending program examples

    Science.gov (United States)

    Hosseini, Roya; Brusilovsky, Peter

    2017-07-01

    This paper investigates a range of concept-based example recommendation approaches that we developed to provide example-based problem-solving support in the domain of programming. The goal of these approaches is to offer students a set of most relevant remedial examples when they have trouble solving a code comprehension problem where students examine a program code to determine its output or the final value of a variable. In this paper, we use the ideas of semantic-level similarity-based linking developed in the area of intelligent hypertext to generate examples for the given problem. To determine the best-performing approach, we explored two groups of similarity approaches for selecting examples: non-structural approaches focusing on examples that are similar to the problem in terms of concept coverage and structural approaches focusing on examples that are similar to the problem by the structure of the content. We also explored the value of personalized example recommendation based on student's knowledge levels and learning goal of the exercise. The paper presents concept-based similarity approaches that we developed, explains the data collection studies and reports the result of comparative analysis. The results of our analysis showed better ranking performance of the personalized structural variant of cosine similarity approach.

  9. Beyond maturity

    International Nuclear Information System (INIS)

    Tessmer, W.B.

    1990-01-01

    The Nuclear Power Plant Simulator Industry has undergone to decades of evolution in experience, technology and business practices. Link-Miles Simulation Corporation (LMSC) has been contracted to build 68 Full Scope Nuclear Simulators during the 1970's and 1980's. Traditional approaches to design, development and testing have been used to satisfy specifications for initial customer requirements. However, the Industry has matured. All U.S. Nuclear Utilities own, or have under contract, at least one simulator. Other industrial nations have centralized training facilities to satisfy the simulator training needs. The customer of the future is knowledgeable and experienced in the development and service of nuclear simulators. The role of the simulator vendor is changing in order to alter the traditional approach for development. Covenants between the vendors and their customers solidify new complementary roles. This paper presents examples of current simulator project development with recommendations for future endeavors

  10. Evaluation of a Junior High School Program Designed to Improve Reading, Self-Concept, and Classroom Behavior.

    Science.gov (United States)

    Miller, Margery Staman

    Two groups of seventh-grade students participated in a comparison of the effects of an experimental remedial reading program emphasizing positive self-concept and improved behavior and a control program. A total of 57 students participated in the thirty-week program. Results from the Coopersmith Self-Esteem Inventory, the Stanford Diagnostic…

  11. Self-concept of people with intellectual disabilities: Implications for support program development

    Directory of Open Access Journals (Sweden)

    Petrović Boban

    2012-01-01

    Full Text Available Self-concept is defined as a sum of perception, thoughts, feelings, evaluation and prediction about oneself as an experienced object, as a participant in the interaction with physical and social environment. As such, this topic is often encountered in working with children, young people and adults with intellectual disabilities (PWID. However, self-concept of PWID has been investigated mainly through psychometric paradigm, using different types of questionnaires for assessment. This did not provide either enough possibilities for active participation of people with ID in the research process, or the possibilities to reach adequate initial information about self-concept of PWID, which may serve as a baseline for development of support programs for self-determination of PWID. Therefore, this study aimed to examine self-concept of PWID in various domains of interest for PWID: global self-image, personality traits, competencies, difficulties in everyday life, awareness of one's own (intellectual disabilities. The research was conducted through a series of five focus groups, with active participation of PWID, through combined workshop activities and discussions in small groups. Focus groups were conducted once a week and 16 participants were divided into two groups, of different ages (22 to 53 years, sex, type and degree of difficulties. All participants spent most of their lives in institutions. Since 2004, they have been living at supported housing for people with disabilities. Based on the analysis of the participants' testimony, there were three global issues with regard to general self-concept: competences and interests, physical appearance, and social roles. With regard to personality traits, attributes such as 'good', 'obedient', 'valuable' occur most frequently. With regard to their competencies and difficulties, those which are most important for full daily life in supported housing have been cited most often. While they recognize their

  12. A program to develop advanced EBT [ELMO Bumpy Torus] concepts and international collaboration on the Bumpy Torus concept: Final report

    International Nuclear Information System (INIS)

    1987-01-01

    This project was undertaken to develop innovative concepts for improving the performance of ELMO Bumpy Torus devices in those aspects of plasma confinement that are particularly relevant to an eventual EBT reactor concept. These include effective magnetic utilization using Andreoletti coils, enhanced confinement using positive ambipolar potentials, and attractive divertor concepts that are compatible with formation and maintenance of ELMO rings. Each of the three major objectives was achieved and, except for the divertor studies, documented for publication and presentation at major scientific meetings. This report provides a brief recapitulation of the major results achieved in the form of a collection of those publications, together with this Introduction

  13. Learning abstract visual concepts via probabilistic program induction in a Language of Thought.

    Science.gov (United States)

    Overlan, Matthew C; Jacobs, Robert A; Piantadosi, Steven T

    2017-11-01

    The ability to learn abstract concepts is a powerful component of human cognition. It has been argued that variable binding is the key element enabling this ability, but the computational aspects of variable binding remain poorly understood. Here, we address this shortcoming by formalizing the Hierarchical Language of Thought (HLOT) model of rule learning. Given a set of data items, the model uses Bayesian inference to infer a probability distribution over stochastic programs that implement variable binding. Because the model makes use of symbolic variables as well as Bayesian inference and programs with stochastic primitives, it combines many of the advantages of both symbolic and statistical approaches to cognitive modeling. To evaluate the model, we conducted an experiment in which human subjects viewed training items and then judged which test items belong to the same concept as the training items. We found that the HLOT model provides a close match to human generalization patterns, significantly outperforming two variants of the Generalized Context Model, one variant based on string similarity and the other based on visual similarity using features from a deep convolutional neural network. Additional results suggest that variable binding happens automatically, implying that binding operations do not add complexity to peoples' hypothesized rules. Overall, this work demonstrates that a cognitive model combining symbolic variables with Bayesian inference and stochastic program primitives provides a new perspective for understanding people's patterns of generalization. Copyright © 2017 Elsevier B.V. All rights reserved.

  14. Models for mature T-cell lymphomas--a critical appraisal of experimental systems and their contribution to current T-cell tumorigenic concepts.

    Science.gov (United States)

    Warner, Kathrin; Crispatzu, Giuliano; Al-Ghaili, Nabil; Weit, Nicole; Florou, Vaia; You, M James; Newrzela, Sebastian; Herling, Marco

    2013-12-01

    Mature T-cell lymphomas/leukemias (MTCL) have been understudied lymphoid neoplasms that currently receive growing attention. Our historically rudimentary molecular understanding and dissatisfactory interventional success in this complex and for the most part poor-prognostic group of tumors is only slightly improving. A major limiting aspect in further progress in these rare neoplasms is the lack of suitable model systems that would substantially facilitate pathogenic studies and pre-clinical drug evaluations. Such representations of MTCL have thus far not been systematically appraised. We therefore provide an overview on existing models and point out their particular advantages and limitations in the context of the specific scientific questions. After addressing issues of species-specific differences and classifications, we summarize data on MTCL cell lines of human as well as murine origin, on murine strain predispositions to MTCL, on available models of genetically engineered mice, and on transplant systems. From an in-silico meta-analysis of available primary data of gene expression profiles on human MTCL we cross-reference genes reported to transform T-cells in mice and reflect on their general vs entity-restricted relevance and on target-promoter influences. Overall, we identify the urgent need for new models of higher fidelity to human MTCL with respect to their increasingly recognized diversity and to predictions of drug response. Copyright © 2013 Elsevier Ireland Ltd. All rights reserved.

  15. Maturity models in supply chain sustainability

    DEFF Research Database (Denmark)

    Correia, Elisabete; Carvalho, Helena; Azevedo, Susana G.

    2017-01-01

    A systematic literature review of supply chain maturity models with sustainability concerns is presented. The objective is to give insights into methodological issues related to maturity models, namely the research objectives; the research methods used to develop, validate and test them; the scope...... of maturity levels. The comprehensive review, analysis, and synthesis of the maturity model literature represent an important contribution to the organization of this research area, making possible to clarify some confusion that exists about concepts, approaches and components of maturity models...

  16. Environmental assessment for the satellite power system concept development and evaluation program: atmospheric effects

    International Nuclear Information System (INIS)

    Rote, D.M.; Brubaker, K.L.; Lee, J.L.

    1980-11-01

    The US Department of Energy (DOE) has undertaken a preliminary, three-year program to investigate the impacts of the construction and operation of a satellite power system, of unprecedented scale. The Department of Energy's program, titled The Concept Development and Evaluation Program, focused its investigations on a Reference System description that calls for the use of either silicon (Si) or gallium aluminum-arsenide (GaAlAs) photovoltaic cells on 60 satellites to be constructed in GEO over a 30-yr period. Rectennas would be constructed on the ground to receive microwave energy from the satellites. Each satellite-rectenna pair is designed to produce 5 GW of power on an essentially continuous basis for use as a baseload power source for an electric power distribution system. The environmental assessment part of the program was divided into five interdependent task areas. The present document constitutes the final technical report on one of the five task areas, the Assessment of the Atmospheric Effects, and as such presents an in-depth summary of work performed during the assessment program. The issues associated with SPS activities in the troposphere are examined. These include tropospheric weather modification related to rectenna operations and rocket launches, and air quality impacts related to rocketlaunch ground clouds. Then progressing upward through the various levels of the atmosphere, the principal middle and upper atmospheric effects associated with rocket effluents are analyzed. Finally, all of the potential SPS atmospheric effects are summarized

  17. NASA's Advanced Information Systems Technology (AIST) Program: Advanced Concepts and Disruptive Technologies

    Science.gov (United States)

    Little, M. M.; Moe, K.; Komar, G.

    2014-12-01

    NASA's Earth Science Technology Office (ESTO) manages a wide range of information technology projects under the Advanced Information Systems Technology (AIST) Program. The AIST Program aims to support all phases of NASA's Earth Science program with the goal of enabling new observations and information products, increasing the accessibility and use of Earth observations, and reducing the risk and cost of satellite and ground based information systems. Recent initiatives feature computational technologies to improve information extracted from data streams or model outputs and researchers' tools for Big Data analytics. Data-centric technologies enable research communities to facilitate collaboration and increase the speed with which results are produced and published. In the future NASA anticipates more small satellites (e.g., CubeSats), mobile drones and ground-based in-situ sensors will advance the state-of-the-art regarding how scientific observations are performed, given the flexibility, cost and deployment advantages of new operations technologies. This paper reviews the success of the program and the lessons learned. Infusion of these technologies is challenging and the paper discusses the obstacles and strategies to adoption by the earth science research and application efforts. It also describes alternative perspectives for the future program direction and for realizing the value in the steps to transform observations from sensors to data, to information, and to knowledge, namely: sensor measurement concepts development; data acquisition and management; data product generation; and data exploitation for science and applications.

  18. Teaching and Understanding the Concept of Critical Thinking Skills within Michigan Accredited Associate Degree Dental Hygiene Programs

    Science.gov (United States)

    Beistle, Kimberly S.

    2012-01-01

    This study explores dental hygiene faculty's perceptions regarding the issues surrounding the concept of critical thinking skills integration within Michigan accredited associate degree dental hygiene programs. The primary research goals are to determine faculty understanding of the concept of critical thinking, identify personal and departmental…

  19. Risk Scan: A Review of Risk Assessment Capability and Maturity within the Canadian Safety and Security Program

    Science.gov (United States)

    2014-06-01

    SCADA / ICS Cyber Test Lab initiated in 2013 Psychosocial – academic research exists,; opportunity for sharing and developing impact assessment...ecosystems and species at risk), accidents / system failure (rail; pipelines ; ferries CSSP strategy for the North Focus on regional l(and local) problem...Guidance; business planning; environmental scan; proposal evaluation; and performance measurement Program Risk Management – Guidelines for project

  20. Automated a complex computer aided design concept generated using macros programming

    Science.gov (United States)

    Rizal Ramly, Mohammad; Asrokin, Azharrudin; Abd Rahman, Safura; Zulkifly, Nurul Ain Md

    2013-12-01

    Changing a complex Computer Aided design profile such as car and aircraft surfaces has always been difficult and challenging. The capability of CAD software such as AutoCAD and CATIA show that a simple configuration of a CAD design can be easily modified without hassle, but it is not the case with complex design configuration. Design changes help users to test and explore various configurations of the design concept before the production of a model. The purpose of this study is to look into macros programming as parametric method of the commercial aircraft design. Macros programming is a method where the configurations of the design are done by recording a script of commands, editing the data value and adding a certain new command line to create an element of parametric design. The steps and the procedure to create a macro programming are discussed, besides looking into some difficulties during the process of creation and advantage of its usage. Generally, the advantages of macros programming as a method of parametric design are; allowing flexibility for design exploration, increasing the usability of the design solution, allowing proper contained by the model while restricting others and real time feedback changes.

  1. Automated a complex computer aided design concept generated using macros programming

    International Nuclear Information System (INIS)

    Ramly, Mohammad Rizal; Asrokin, Azharrudin; Rahman, Safura Abd; Zulkifly, Nurul Ain Md

    2013-01-01

    Changing a complex Computer Aided design profile such as car and aircraft surfaces has always been difficult and challenging. The capability of CAD software such as AutoCAD and CATIA show that a simple configuration of a CAD design can be easily modified without hassle, but it is not the case with complex design configuration. Design changes help users to test and explore various configurations of the design concept before the production of a model. The purpose of this study is to look into macros programming as parametric method of the commercial aircraft design. Macros programming is a method where the configurations of the design are done by recording a script of commands, editing the data value and adding a certain new command line to create an element of parametric design. The steps and the procedure to create a macro programming are discussed, besides looking into some difficulties during the process of creation and advantage of its usage. Generally, the advantages of macros programming as a method of parametric design are; allowing flexibility for design exploration, increasing the usability of the design solution, allowing proper contained by the model while restricting others and real time feedback changes

  2. [The connective tissues, from the origin of the concept to its "Maturation" to extracellular matrix. Application to ocular tissues. Contribution to the history of medical sciences].

    Science.gov (United States)

    Labat-Robert, J; Robert, L; Pouliquen, Y

    2011-06-01

    The "Tissue" concept emerged apparently in the medical literature at about the French revolution, during the second half of the 18(th) century. It was found in the texts written by the physicians of Béarn and Montpellier, the Bordeu-s and also by the famous physician, Felix Vicq d'Azyr, the last attending physician of the queen Marie-Antoinette, "Bordeu et al. (1775) et Pouliquen (2009)". It was elaborated into a coherent doctrine somewhat later by Xavier Bichat, considered as the founder of modern pathological anatomy, Bichat. With the advent of histochemistry, from the beginning of the 20(th) century, several of the principal macromolecular components of connective tissues, collagens, elastin, "acid mucopolysaccharides" (later glycosaminoglycans and proteoglycans) and finally structural glycoproteins were characterized. These constituents of connective tissues were then designated as components of the extracellular matrix (ECM), closely associated to the cellular components of these tissues by adhesive (structural) glycoproteins as fibronectin, several others and cell receptors, "recognising" ECM-components as integrins, the elastin-receptor and others. This molecular arrangement fastens cells to the ECM-components they synthesize and mediates the exchange of informations between the cells to the ECM (inside-out) and also from the ECM-components to the cells (outside-in). This macromolecular arrangement is specific for each tissue as a result of the differentiation of their cellular components. It is also the basis and condition of the fulfillment of the specific functions of differentiated tissues. This is a short description of the passage of the "tissue" concept from its vague origin towards its precise identification at the cellular and molecular level up to the recognition of its functional importance and its establishment as an autonomous science. This can be considered as a new example of the importance of metaphors for the progress of science, Keller

  3. Reactor physical program in the frame of the MSR-SPHINX transmuter concept development

    International Nuclear Information System (INIS)

    Hron, M.; Mikisek, M.

    2008-01-01

    In the frame of the R and D program for the Molten Salt Reactor (MSR) - SPHINX (Spent Hot fuel Incinerator by Neutron flux) concept, which has been under development in the Czech Republic as an actinide burner in resonance neutron spectrum and a radionuclide transmuter in a well-thermalized neutron spectrum, and namely its reactor physical part, the relatively broad experimental activities have been involved in the program, recently, which will serve for a validation of computer codes and verification of design inputs for designing of a demonstration unit of the MSR-type. The experimental program, which has been focused, in its first stage, on a short-term irradiation of small size samples of molten-salt systems as well as structural materials proposed for the MSR blanket in the field of high neutron flux of research reactors, will be in the proposed next stage of the program focused on a large-scale experimental verification of design inputs by use of MSR-type inserted zones into the existing light water moderated experimental reactor LR-0, which may allow to modify it to experimental zero power salt reactor SR-0. There has been a preparatory stage of the project called EROS started in the year 2006 and new experiments with MSR-type zones irradiated by cyclotron based neutron source are planned at the end of 2007 and should go on in the year 2008. There will be a brief description of the so far prepared and performed experimental programs introduced in the paper. (authors)

  4. Revisiting the concept of growth monitoring and its possible role in community-based nutrition programs.

    Science.gov (United States)

    Mangasaryan, Nuné; Arabi, Mandana; Schultink, Werner

    2011-03-01

    Community-based growth monitoring (GM) and growth monitoring and promotion (GMP) have been implemented worldwide. The literature provides controversial messages regarding their effectiveness. Numerous countries have GM as their main community-based activity and need guidance for future programming. The notion of GM is usually clear, but the follow-up actions include a range of activities and interventions, all under the heading of "promotion." We suggested definitions, objectives, and outcomes of the GM and GMP. By providing some clarity on these conceptual issues we attempted to provide a basis for consensus building and development of recommendations on when this activity should be promoted or discouraged. We reviewed basic concepts and global experience of GM and GMP using publications about GM and GMP, UNICEF country reports and other publications, field observations, and reports of recent expert consultations. Realistic added benefits are suggested as compared with general counseling that could also be delivered outside the GM session. We provide a narrow definition of "promotion" in GMP, in which actions are tailored to the results of monitoring, as well as suggest quality implementation criteria. GM, even if complemented by a promotional package, can have only a limited impact if it is not part of a comprehensive program. GMP cannot be viewed as a competitor to highly effective interventions, but may serve as a possible platform for their delivery. The decision to build community-based programs on a GMP platform should be based on consideration of benefits, feasibility of quality implementation, and capacity of human resources.

  5. Hardware test program for evaluation of baseline range-range rate sensor concept

    Science.gov (United States)

    1985-01-01

    The baseline range/range rate sensor concept was evaluated. The Interrupted CW (ICW) mode of operation continued with emphasis on establishing the sensitivity of the video portion of the receiver was 7 dB less than the theoretical value. This departs from test results of previous implementations in which achieved sensitivity was within 1.5 to 2 dB of the theoretical value. Several potential causes of this discrepancy in performance were identified and are scheduled for further investigation. Results indicate that a cost savings in both per unit and program costs are realizable by eliminating one of the modes of operation. An acquisition (total program) cost savings of approximately 10% is projected by eliminating the CW mode of operation. The modified R/R sensor would operate in the ICW mode only and would provide coverage from initial acquisition at 12 nmi to within a few hundred feet of the OMV. If the ICW mode only were selected, then an accompanying sensor would be required to provide coverage from a few hundred feet to docking.

  6. Global agenda, local health: including concepts of health security in preparedness programs at the jurisdictional level.

    Science.gov (United States)

    Eby, Chas

    2014-01-01

    The Global Health Security Agenda's objectives contain components that could help health departments address emerging public health challenges that threaten the population. As part of the agenda, partner countries with advanced public health systems will support the development of infrastructure in stakeholder health departments. To facilitate this process and augment local programs, state and local health departments may want to include concepts of health security in their public health preparedness offices in order to simultaneously build capacity. Health security programs developed by public health departments should complete projects that are closely aligned with the objectives outlined in the global agenda and that facilitate the completion of current preparedness grant requirements. This article identifies objectives and proposes tactical local projects that run parallel to the 9 primary objectives of the Global Health Security Agenda. Executing concurrent projects at the international and local levels in preparedness offices will accelerate the completion of these objectives and help prevent disease epidemics, detect health threats, and respond to public health emergencies. Additionally, future funding tied or related to health security may become more accessible to state and local health departments that have achieved these objectives.

  7. Interdisciplinary Approaches at Institutions of Higher Education: Teaching Information Systems Concepts to Students of Non-Computer Science Programs

    Directory of Open Access Journals (Sweden)

    Roland Schwald

    2011-07-01

    Full Text Available The aim of this paper is to present a curriculum development concept for teaching information systems content to students enrolled in non-computer science programs by presenting examples from the Business Administration programs at Albstadt-Sigmaringen University, a state university located in Southern Germany. The main focus of this paper therefore is to describe this curriculum development concept. Since this concept involves two disciplines, i.e. business administration and computer science, the author argues that it is necessary to define the roles of one discipline for the other and gives an example on how this could be done. The paper acknowledges that the starting point for the development of a curriculum such as one for a business administration program will be the requirements of the potential employers of the graduates. The paper continues to recommend the assignment of categorized skills and qualifications, such as knowledge, social, methodological, and decision making skills to the different parts of the curricula in question for the development of such a curriculum concept. After the mapping of skills and courses the paper describes how specific information systems can be used in courses, especially those with a specific focus on methodological skills. Two examples from Albstadt-Sigma-ringen University are being given. At the end of the paper the author explains the implications and limitations of such a concept, especially for programs that build on each other, as is the case for some Bachelor and Master programs. The paper concludes that though some elements of this concept are transferable, it is still necessary that every institution of higher education has to take into consideration its own situation to develop curricula concepts. It provides recommendations what issues every institution should solve for itself.

  8. Final Project Report "Advanced Concept Exploration For Fast Ignition Science Program"

    Energy Technology Data Exchange (ETDEWEB)

    STEPHENS, Richard B.; McLEAN, Harry M.; THEOBALD, Wolfgang; AKLI, Kramer; BEG, Farhat N.; SENTOKU, Yasuiko; SCHUMACHER, Douglas; WEI, Mingsheng S.

    2014-01-31

    and x-ray line radiation from K-shell fluorescence. Integrated experiments, which combine target compression with short-pulse laser heating, yield additional information on target heating efficiency. This indirect way of studying the underlying behavior of the electrons must be validated with computational modeling to understand the physics and improve the design. This program execution required a large, well-organized team and it was managed by a joint Collaboration between General Atomics (GA), Lawrence Livermore National Laboratory (LLNL), and the Laboratory for Laser Energetics (LLE). The Collaboration was formed 8 years ago to understand the physics issues of the Fast Ignition concept, building on the strengths of each partner. GA fulfills its responsibilities jointly with the University of California, San Diego (UCSD), The Ohio State University (OSU) and the University of Nevada at Reno (UNR). Since RHED physics is pursued vigorously in many countries, international researchers have been an important part of our efforts to make progress. The division of responsibility was as follows: (1) LLE had primary leadership for channeling studies and the integrated energy transfer, (2) LLNL led the development of measurement methods, analysis, and deployment of diagnostics, and (3) GA together with UCSD, OSU and UNR studied the detailed energy-transfer physics. The experimental program was carried out using the Titan laser at the Jupiter Laser Facility at LLNL, the OMEGA and OMEGA EP lasers at LLE and the Texas Petawatt laser (TPW) at UT Austin. Modeling has been pursued on large computing facilities at LLNL, OSU, and UCSD using codes developed (by us and others) within the HEDLP program, commercial codes, and by leveraging existing supercomputer codes developed by the NNSA ICF program. This Consortium brought together all the components—resources, facilities, and personnel—necessary to accomplish its aggressive goals. The ACE Program has been strongly collaborative

  9. Maturing Technologies for Stirling Space Power Generation

    Science.gov (United States)

    Wilson, Scott D.; Nowlin, Brentley C.; Dobbs, Michael W.; Schmitz, Paul C.; Huth, James

    2016-01-01

    Stirling Radioisotope Power Systems (RPS) are being developed as an option to provide power on future space science missions where robotic spacecraft will orbit, flyby, land or rove. A Stirling Radioisotope Generator (SRG) could offer space missions a more efficient power system that uses one fourth of the nuclear fuel and decreases the thermal footprint of the current state of the art. The RPS Program Office, working in collaboration with the U.S. Department of Energy (DOE), manages projects to develop thermoelectric and dynamic power systems, including Stirling Radioisotope Generators (SRGs). The Stirling Cycle Technology Development (SCTD) Project, located at Glenn Research Center (GRC), is developing Stirling-based subsystems, including convertors and controllers. The SCTD Project also performs research that focuses on a wide variety of objectives, including increasing convertor temperature capability to enable new environments, improving system reliability or fault tolerance, reducing mass or size, and developing advanced concepts that are mission enabling. Research activity includes maturing subsystems, assemblies, and components to prepare them for infusion into future convertor and generator designs. The status of several technology development efforts are described here. As part of the maturation process, technologies are assessed for readiness in higher-level subsystems. To assess the readiness level of the Dual Convertor Controller (DCC), a Technology Readiness Assessment (TRA) was performed and the process and results are shown. Stirling technology research is being performed by the SCTD Project for NASA's RPS Program Office, where tasks focus on maturation of Stirling-based systems and subsystems for future space science missions.

  10. Structural equation modeling with LISREL, PRELIS, and SIMPLIS basic concepts, applications, and programming

    CERN Document Server

    Byrne, Barbara M

    2013-01-01

    This book illustrates the ease with which various features of LISREL 8 and PRELIS 2 can be implemented in addressing research questions that lend themselves to SEM. Its purpose is threefold: (a) to present a nonmathmatical introduction to basic concepts associated with SEM, (b) to demonstrate basic applications of SEM using both the DOS and Windows versions of LISREL 8, as well as both the LISREL and SIMPLIS lexicons, and (c) to highlight particular features of the LISREL 8 and PRELIS 2 progams that address important caveats related to SEM analyses. This book is intended neither as a text on the topic of SEM, nor as a comprehensive review of the many statistical funcitons available in the LISREL 8 and PRELIS 2 programs. Rather, the intent is to provide a practical guide to SEM using the LISREL approach. As such, the reader is "walked through" a diversity of SEM applications that include both factor analytic and full latent variable models, as well as a variety of data management procedures.

  11. Creating broad acceptance of novel nuclear concepts (A progress report on relevant ISTC programs)

    Energy Technology Data Exchange (ETDEWEB)

    Tocheny, Lev V. [ISTC - International Science and Technology Center, Krasnoproletarskaya 32-34, POBox 20, 127473 Moscow (Russian Federation)

    2008-07-01

    The International Science and Technology Center (ISTC) is a unique international organization created in Moscow more than twelve years ago by Russia, USA, EU and Japan. Later Korea and Canada, and several CIS countries as well acceded to ISTC. The basic idea behind establishing the ISTC was to support non-proliferation of the mass destruction weapons technologies by re-directing former Soviet weapons scientists to peaceful research thus preventing the drain of dangerous knowledge and expertise from Russia and other CIS countries. Numerous science and technology projects are realized with the ISTC support in different areas, from bio-technologies and environmental problems to all aspects of nuclear studies, including those focused on the development of effective innovative concepts and technologies in the nuclear field, in general, and for improvement of nuclear safety, in particular. Presently, the ISTC has 40 member countries (27 from EU), representing the CIS, Europe, Asia, and North America. The Partner list includes over 180 organizations and leading industrial companies from all ISTC parties. ISTC Activities to the end of 2007 above 2500 projects approved for funding. More than 350 institutions and 35,000 specialists received grants from ISTC. The presentation addresses some consequences of the ISTC projects and programs, related to nuclear science and technologies, as well as methods and approaches employed by the ISTC to foster close international collaboration and joint manage projects towards fruitful results. (authors)

  12. Creating broad acceptance of novel nuclear concepts (A progress report on relevant ISTC programs)

    International Nuclear Information System (INIS)

    Tocheny, Lev V.

    2008-01-01

    The International Science and Technology Center (ISTC) is a unique international organization created in Moscow more than twelve years ago by Russia, USA, EU and Japan. Later Korea and Canada, and several CIS countries as well acceded to ISTC. The basic idea behind establishing the ISTC was to support non-proliferation of the mass destruction weapons technologies by re-directing former Soviet weapons scientists to peaceful research thus preventing the drain of dangerous knowledge and expertise from Russia and other CIS countries. Numerous science and technology projects are realized with the ISTC support in different areas, from bio-technologies and environmental problems to all aspects of nuclear studies, including those focused on the development of effective innovative concepts and technologies in the nuclear field, in general, and for improvement of nuclear safety, in particular. Presently, the ISTC has 40 member countries (27 from EU), representing the CIS, Europe, Asia, and North America. The Partner list includes over 180 organizations and leading industrial companies from all ISTC parties. ISTC Activities to the end of 2007 above 2500 projects approved for funding. More than 350 institutions and 35,000 specialists received grants from ISTC. The presentation addresses some consequences of the ISTC projects and programs, related to nuclear science and technologies, as well as methods and approaches employed by the ISTC to foster close international collaboration and joint manage projects towards fruitful results. (authors)

  13. MD3M: The Master Data Management Maturity Model

    NARCIS (Netherlands)

    Spruit, Marco|info:eu-repo/dai/nl/297391879; Pietzka, Katharina

    2015-01-01

    This research aims to assess the master data maturity of an organization. It is based on thorough literature study to derive the main concepts and best practices in master data maturity assessment. A maturity matrix relating 13 focus areas and 65 capabilities was designed and validated. Furthermore,

  14. Pilot program (proof of concept) to mitigate Phytophthora ramorum at an infested nursery based on a systems approach

    Science.gov (United States)

    Gary Chastagner; Marianne Elliott

    2017-01-01

    The primary purpose of this program was to demonstrate proof of concept of certain mitigation approaches at a repeat P. ramorum-positive nursery site in Washington. Approaches included steam treatment of infested soil areas; creating a gravel “sandwich” above steam-treated and potentially infested soil surfaces; improving drainage systems; required...

  15. Applying Marketing Concepts to Non-Profit/Educational Organizations: The Youth Professional’s Responsibilities in Program Marketing & Promotion

    Directory of Open Access Journals (Sweden)

    Keith G. Diem

    2008-12-01

    Full Text Available The degree of participation in community-based youth development programs is typically affected by both the recruitment and retention of participants. A review of literature over more than forty years revealed the value of marketing and promotion to the viability of a company, product, or organization and how it may contribute to company sales or an organization’s membership. This article is focused on the application of marketing concepts to a non-profit organization or educational program. Using a marketing approach to program development can result in improved program quality as well as increased enrollment. Utilizing marketing activities such as needs assessment will aide in ensuring the program remains current in meeting needs and interests of clientele, the community, and society. Promoting an accurate and relevant image is a key in making sure people realize the value of your program.

  16. A three-step programmed method for the identification of causative gene mutations of maturity onset diabetes of the young (MODY).

    Science.gov (United States)

    Li, Qian; Cao, Xi; Qiu, Hai-Yan; Lu, Jing; Gao, Rui; Liu, Chao; Yuan, Ming-Xia; Yang, Guang-Ran; Yang, Jin-Kui

    2016-08-22

    To establish a three-step programmed method to find gene mutations related to maturity onset diabetes of the young (MODY). Target region capture and next-generation sequencing (NGS) were performed using customized oligonucleotide probes designed to capture suspected genes for MODY in 11 probands with clinically diagnosed MODY. The suspected associations of certain genes with MODY were then confirmed by Sanger sequencing in the probands and their family members. Finally, to validate variants of one of the genes of interest (glucokinase, GCK) as pathogenic mutations, protein function editing by the variant genes was assessed. In the target region capture and NGS phase, a total of nine variants of seven genes (GCK, WFS1, SLC19A2, SH2B1, SERPINB4, RFX6, and GATA6) were identified in eight probands. Two heterozygous GCK mutations located on the same allele (p.Leu77Arg and p.Val101Met) were identified in a MODY family. Sanger sequencing was used to confirm the variants identified by NGS to be present in probands and their diabetic family members, but not in non-diabetic family members. Finally, enzyme kinetic and thermal stability analyses revealed that the p.Leu77Arg mutation or the p.Leu77Arg mutation in combination with the p.Val101Met mutation inactivates GCK function and stability, while mutation of p.Val101Met alone does not. The p.Leu77Arg but not p.Val101Met GCK mutation is therefore considered a pathogenic mutation associated with MODY. Genetic screening coupled with gene-editing protein function testing is an effective and reliable method by which causative gene mutations of MODY can be identified. Copyright © 2016 Elsevier B.V. All rights reserved.

  17. Developmental Plasticity in Child Growth and Maturation

    Directory of Open Access Journals (Sweden)

    Ze'ev eHochberg

    2011-09-01

    Full Text Available The ability of a given genotype to produce different phenotypes in response to different environments is termed "plasticity", and is part of the organism's "adaptability" to environmental cues. The expressions of suites of genes, particularly during development or life-history transitions, probably underlie the fundamental plasticity of an organism. Plasticity in developmental programming has evolved in order to provide the best chances of survival and reproductive success to organisms under changing environments. Environmental conditions that are experienced in early life can profoundly influence human biology, child growth and maturation, and long-term health and longevity. Developmental origins of health and disease and life history transitions are purported to use placental, nutritional, and endocrine cues for setting long-term biological, mental, and behavioral strategies for child growth and maturation in response to local ecological and/or social conditions. The window of developmental plasticity extends from conception to early childhood, and even beyond to the transition from juvenility to adoelscence, and could be transmitted transgenerationally. It involves epigenetic responses to environmental changes, which exert their effects during life history phase-transitions.

  18. Slab replacement maturity guidelines.

    Science.gov (United States)

    2014-04-01

    This study investigated the use of maturity method to determine early age strength of concrete in slab : replacement application. Specific objectives were (1) to evaluate effects of various factors on the compressive : maturity-strength relationship ...

  19. Challenges and weaknesses in the use of concept maps as a learning strategy in undergraduate health programs

    Directory of Open Access Journals (Sweden)

    Enios Carlos Duarte

    2017-09-01

    Full Text Available This paper considers the analysis of concept maps utilized as a learning tool in disciplines dealing with immunological responses in two undergraduate Health programs. In total, 48 concept maps were assessed regarding their propositions and structure. The clarity of the propositions was analyzed by using the Propositional Clarity Table and they were classified as adequate propositions (AP and inadequate propositions (IP. In 48 concept maps, 648 propositions were analyzed in order to determine semantic clarity and conceptual mistakes. Assessments revealed that 69 % of the propositions were classified as adequate and 31 % as inadequate. All the maps analyzed were categorized as showing a network structure. However, when correlating the connections established among the several types of response by the immune system, it was found that despite being structured as a network, only 31.2 % of the concept maps indicated conceptual relationships between the modes of immune response. 27% of the concept maps were made with a high rate of proficiency. Upon the results of our analysis, we realized that there is still a long way in developing the mapping strategy. For us, this low percentage is related to the way undergraduates assimilate the mapping processes. This is a challenge which also reveals limits and weaknesses that may be addressed in future studies. It was noted that results bring into focus that the undergraduates’ learning of concepts associated with the bases of the immunological responses occurred in a meaningful way.

  20. Connected vehicle pilot deployment program phase 1, concept of operations (ConOps) - New York City.

    Science.gov (United States)

    2016-04-08

    This document describes the Concept of Operations (ConOps) for the New York City Department of Transportation (NYC) Connected Vehicle Pilot Deployment (CVPD) Project. This ConOps describes the current state of operations, establishes the reasons for ...

  1. Connected Vehicle Pilot Deployment Program phase 1 : security management operating concept : New York City : final report.

    Science.gov (United States)

    2016-05-18

    This document describes the Security Management Operating Concept (SMOC) for the New York City Department of Transportation (NYCDOT) Connected Vehicle Pilot Deployment (CVPD) Project. This SMOC outlines the security mechanisms that will be used to pr...

  2. Epistemological obstacles on the concepts of limit and continuity in courses of differential calculus in engineering programs

    Directory of Open Access Journals (Sweden)

    Cesar Augusto Hernandez-Suarez

    2017-07-01

    Full Text Available Many investigations have been carried out with the objective of identifying the difficulties that students have in the learning process of the different mathematical concepts. Some studies have highlighted that the process of teaching mathematical knowledge by teachers in secondary and secondary education in Colombia, has been limited to a minimalist expression of algebraic processes that in no way contribute to the understanding and appropriation of these concepts of origin abstract. Students who enter the various engineering programs in the university must immediately face a Differential Calculus course, which will demand from the student a whole series of competences around the numerical, variational and spatial thoughts. It is in this scenario where we seek to identify the epistemological obstacles presented by the students of the Faculty of Engineering programs at the beginning of the academic training process at the UFPS. An instrument was designed that incorporates a series of activities that use diverse registers of semiotic representation tending to determine the level of appropriation that the students have around the concepts of limit and continuity. From the findings it is highlighted that students assume the concepts of limit and continuity as equals.

  3. Understanding groundwater - students' pre-conceptions and conceptual change by means of a theory-guided multimedia learning program

    Science.gov (United States)

    Unterbruner, Ulrike; Hilberg, Sylke; Schiffl, Iris

    2016-06-01

    Education on the subject of groundwater is crucial for sustainability. Nevertheless, international studies with students across different age groups have shown that the basic hydrogeological concept of groundwater defined as water within porous and permeable rocks is not an established everyday notion. Drawing from international research, a multimedia learning program Zwischen Regenwolke und Wasserhahn (between the rain cloud and the tap) was developed, which incorporates specific insights from the fields of conceptual change research, multimedia research, and the model of educational reconstruction. The effectiveness of the learning program was ascertained by means of two studies with Austrian seventh grade pupils as well as teacher-training students from the fields of biology and geography in order to ascertain the effectiveness of the learning program. Using a quasi-experimental research design, the participants' conceptions and knowledge of groundwater were determined in a pre- and post-test. The pupils and students greatly benefitted from working through the learning software independently. Their knowledge of groundwater increased significantly compared to the control group and there was a highly significant increase in the number of scientifically correct notions of groundwater. The acceptance of the program was also generally very high. The results indicate that theory-guided multimedia learning programs can play an important role in the transfer of research results to classroom settings, especially in science education.

  4. Advanced concepts under development in the United States Breeder-Fuel-Reprocessing Program

    International Nuclear Information System (INIS)

    Burch, W.D.

    1981-01-01

    Advanced concepts and techniques for the fuel reprocessing step are being developed. These concepts have been incorporated into the conceptual design of a Hot Experimental Facility (HEF), which is intended to demonstrate reprocessing of the first US breeder demonstration reactor. To achieve system reliability and reduce occupational doses, a concept of totally remote operation and maintenance (termed Remotex) has been conceived and is being developed. In this concept, maintenance and mechanical operations are accomplished with remotely operated bilateral force-reflecting electronic master/slave manipulators. Suitable transport systems, coupled with remote closed-circuit television viewing, are provided to extend man's capabilities into the hostile cell environment. New equipment concepts are being developed for the fuel dismantling and shearing step, a high-temperature dry process termed voloxidation to remove tritium, a continuous rotary dissolver, and for an improved centrifugal solvent contractor. Techniques have been developed, using engineering-scale equipment with active tracers for retention of 85 Kr, radioiodine, 14 C, and 3 H

  5. The impact of a 12-week resistance training program on strength, body composition, and self-concept of Hispanic adolescents.

    Science.gov (United States)

    Velez, Amelia; Golem, Devon L; Arent, Shawn M

    2010-04-01

    Current evidence suggests that a resistance training program may be physically and psychologically beneficial for adolescents. The purpose of this study was to examine the effects of a structured resistance training program on strength, body composition, and self-concept in normal and overweight Hispanic adolescents. Male and female participants (n = 28; 16.1 +/- 0.2 y; 164.5 +/- 1.4 cm; 63.3 +/- 2.5 kg; 20.0 +/- 1.7% body fat [BF]) were recruited from a predominantly Hispanic high school. Prior to the 12-week program, strength, body composition, and self-concept were assessed. Subjects were randomly assigned to a control group (CON; n = 15) or to a resistance training group (RT; n = 13) that participated in supervised strength training 3 days/week. All measures were repeated at the end of the 12-week program. RT had significantly greater strength increases for bench press (p increased %BF. RT had an increase in condition/stamina competence (p = 0.008), attractive body adequacy (p = 0.017), and global self-worth (p = 0.013) from pretest to posttest, whereas no change was observed for CON. In conclusion, resistance training resulted in significant physiological and psychological improvements in Hispanic adolescents compared to typical school-based activities. These findings indicate that resistance training can be incorporated into the activities of Hispanic adolescents to promote improved health and fitness.

  6. Understanding groundwater - students' pre-conceptions and conceptual change by a theory-guided multimedia learning program

    Science.gov (United States)

    Unterbruner, U.; Hilberg, S.; Schiffl, I.

    2015-11-01

    Groundwater is a crucial topic in education for sustainable development. Nevertheless, international studies with students of different ages have shown that the basic hydrogeological concept of groundwater defined as water within porous and permeable rocks is not an established everyday notion. Building upon international research a multimedia learning program ("Between the raincloud and the tap") was developed. Insights from the fields of conceptual change research, multimedia research, and the Model of Educational Reconstruction were specifically implemented. Two studies were conducted with Austrian pupils (7th grade) and teacher training students from the fields of biology and geography in order to ascertain the effectiveness of the learning program. Using a quasi-experimental research design, the participants' conceptions and knowledge regarding groundwater were determined in a pre- and post-test. The pupils and students greatly profited from independently working through the learning software. Their knowledge of groundwater increased significantly compared to the control group and there was a highly significant increase in the number of scientifically correct notions of groundwater. The acceptance of the program was also generally very high. The results speak for the fact that theory-guided multimedia learning programs can play an important role in the transfer of research results into the classroom, particularly in science education.

  7. Understanding the Concept of Food Sovereignty Using the Ghana School Feeding Program

    NARCIS (Netherlands)

    Quaye, W.; Ruivenkamp, G.T.P.; Frempong, G.; Essegbey, G.

    2010-01-01

    This article deepens the understanding of the emerging food sovereignty concept using a case study of a home-grown school feeding programme that promotes local food demand - supply linkages. A school feeding programme in four selected districts in Ghana is analysed with respect to community

  8. 76 FR 72220 - Incorporation of Risk Management Concepts in Regulatory Programs

    Science.gov (United States)

    2011-11-22

    ... actions? 4. What are the key characteristics for a holistic risk management regulatory structure for... accomplishing the goal of a holistic risk management regulatory structure? How could these challenges be... NUCLEAR REGULATORY COMMISSION [NRC-2011-0269] Incorporation of Risk Management Concepts in...

  9. MATLAB-Based Program for Teaching Autocorrelation Function and Noise Concepts

    Science.gov (United States)

    Jovanovic Dolecek, G.

    2012-01-01

    An attractive MATLAB-based tool for teaching the basics of autocorrelation function and noise concepts is presented in this paper. This tool enhances traditional in-classroom lecturing. The demonstrations of the tool described here highlight the description of the autocorrelation function (ACF) in a general case for wide-sense stationary (WSS)…

  10. PlayIt: Game Based Learning Approach for Teaching Programming Concepts

    Science.gov (United States)

    Mathrani, Anuradha; Christian, Shelly; Ponder-Sutton, Agate

    2016-01-01

    This study demonstrates a game-based learning (GBL) approach to engage students in learning and enhance their programming skills. The paper gives a detailed narrative of how an educational game was mapped with the curriculum of a prescribed programming course in a computing diploma study programme. Two separate student cohorts were invited to…

  11. Application of room temperature ionic liquids in advanced fuel cycles RIAR research concept program users

    International Nuclear Information System (INIS)

    Bychkov, Alexander V.; Kormilitsyn, Michael V.; Savochkin, Yuri P.; Osipenko, Alexander G.; Smolensky, Valeri V.; Shadrin, Alexander Yu.; Babain, Vladimir A.

    2005-01-01

    The paper reviews briefly the research program on application of Room Temperature Ionic Liquids (RTILs) in some processes of the nuclear fuel reprocessing, particularly in the uranium-aluminum fuel reprocessing and separation of TPEs and REEs from the PUREX process liquid waste, and approaches to implementation of this program. (author)

  12. Program Control as a Set-Theoretic Concept. Research Report RR-94-56.

    Science.gov (United States)

    Wadkins, J. R. Jefferson

    This paper provides operational semantics for imperative programming languages that legitimize the phraseology used in the statement and proof of a fundamental theorem of program correctness. Some of the phrases used in the theorem are normally undefined, but intuitively appealing. This paper attempts to give precise meaning to the questionable…

  13. Community College Healthcare Students' Conceptions of Empathy: A Program-Wide Mixed Methods Case Study

    Science.gov (United States)

    Fields, Kellee M.

    2015-01-01

    Community colleges play a vital role in the education of our Nations healthcare professions. In order to respond to the rising economic and social needs of the healthcare sector, community colleges are meeting the challenge by providing health professions skills and training programs to meet these shortages. These crucial programs are charged with…

  14. The Impact of Different Teaching Approaches and Languages on Student Learning of Introductory Programming Concepts

    Science.gov (United States)

    Kunkle, Wanda M.

    2010-01-01

    Many students experience difficulties learning to program. They find learning to program in the object-oriented paradigm particularly challenging. As a result, computing educators have tried a variety of instructional methods to assist beginning programmers. These include developing approaches geared specifically toward novices and experimenting…

  15. Developmental programming: the concept, large animal models, and the key role of uteroplacental vascular development.

    Science.gov (United States)

    Reynolds, L P; Borowicz, P P; Caton, J S; Vonnahme, K A; Luther, J S; Hammer, C J; Maddock Carlin, K R; Grazul-Bilska, A T; Redmer, D A

    2010-04-01

    Developmental programming refers to the programming of various bodily systems and processes by a stressor of the maternal system during pregnancy or during the neonatal period. Such stressors include nutritional stress, multiple pregnancy (i.e., increased numbers of fetuses in the gravid uterus), environmental stress (e.g., high environmental temperature, high altitude, prenatal steroid exposure), gynecological immaturity, and maternal or fetal genotype. Programming refers to impaired function of numerous bodily systems or processes, leading to poor growth, altered body composition, metabolic dysfunction, and poor productivity (e.g., poor growth, reproductive dysfunction) of the offspring throughout their lifespan and even across generations. A key component of developmental programming seems to be placental dysfunction, leading to altered fetal growth and development. We discuss various large animal models of developmental programming and how they have and will continue to contribute to our understanding of the mechanisms underlying altered placental function and developmental programming, and, further, how large animal models also will be critical to the identification and application of therapeutic strategies that will alleviate the negative consequences of developmental programming to improve offspring performance in livestock production and human medicine.

  16. Drug efficiency: a new concept to guide lead optimization programs towards the selection of better clinical candidates.

    Science.gov (United States)

    Braggio, Simone; Montanari, Dino; Rossi, Tino; Ratti, Emiliangelo

    2010-07-01

    As a result of their wide acceptance and conceptual simplicity, drug-like concepts are having a major influence on the drug discovery process, particularly in the selection of the 'optimal' absorption, distribution, metabolism, excretion and toxicity and physicochemical parameters space. While they have an undisputable value when assessing the potential of lead series or in evaluating inherent risk of a portfolio of drug candidates, they result much less useful in weighing up compounds for the selection of the best potential clinical candidate. We introduce the concept of drug efficiency as a new tool both to guide the drug discovery program teams during the lead optimization phase and to better assess the developability potential of a drug candidate.

  17. A karate program for improving self-concept and quality of life in childhood epilepsy: results of a pilot study.

    Science.gov (United States)

    Conant, Kerry D; Morgan, Amy K; Muzykewicz, David; Clark, Derrick C; Thiele, Elizabeth A

    2008-01-01

    The potential cognitive and psychosocial effects of childhood epilepsy have significant implications for a child's self-image and academic achievement. This study focuses on a 10-week karate program for children and adolescents with epilepsy aimed at increasing social confidence, self-concept, and quality of life, as well as reducing parental anxiety. Eleven children (8-16 years old) and their parents participated in this questionnaire study, and complete data were available for nine of these families. Measures consisted of the Piers-Harris Children's Self-Concept Scale, the Quality of Life in Childhood Epilepsy (QOLCE) questionnaire, and the Parental Stress Index. By parental report, significant improvement in memory function and largely positive trends in quality of life on multiple subscales were observed. By child report, intellectual self-esteem and social confidence also improved. Parental stress decreased, although not significantly, suggesting a potential benefit and indicating a role for future interventions targeting family anxiety.

  18. Program Evaluation: A Consumer Evaluation of Alternative Contractor Concepts in Government Food Service

    Science.gov (United States)

    1974-09-01

    food service facilities. The food factors (quality, variety, and quantity, in that order) were generally rated by consumers as most serious problems, in keeping with many previous survey studies of military food service system. The contractor food service concept with raw food provided by the contractor, as exemplified by Fort Myer, significantly reduced consumer problems in food service personnel, speed, hours, environment, and convenience of location, and also reduced the degree to which food variety,

  19. The influence of an inquiry professional development program on secondary science teachers' conceptions and use of inquiry teaching

    Science.gov (United States)

    Lotter, Christine

    2005-11-01

    This research investigated nine secondary science teachers' conceptions and use of inquiry teaching throughout a year-long professional development program. The professional development program consisted of a two-week summer inquiry institute and research experience in university scientists' laboratories, as well as three academic year workshops. Teachers' conceptions of inquiry teaching were established through both qualitative interviews and a quantitative instrument given before and after the summer institute and again at the end of the academic year. Videotapes of all nine teachers presenting inquiry lessons in their own classrooms were evaluated using an observation protocol that measured the teachers' degree of reform teaching. Three of the teachers were chosen for an in-depth case study of their classroom teaching practices. Data collected from each of the case study teachers included videotapes from classroom observations, responses to an inquiry survey, and transcripts from two additional qualitative interviews. Students' responses to their teachers' use of inquiry teaching were also investigated in the case study classrooms. Through their participation in the professional development experience, the teachers gained a deeper understanding of how to implement inquiry practices in their classrooms. The teachers gained confidence and practice with inquiry methods through developing and presenting their institute-developed inquiry lessons, through observing other teachers' lessons, and participating as students in the workshop inquiry activities. Data analysis revealed that the teachers' knowledge of inquiry was necessary but not sufficient for their implementation of inquiry teaching practices. The teachers' conceptions of science, their students, effective teaching practices, and the purpose of education were found to have a direct effect on the type and amount of inquiry instruction performed in the high school classrooms. The research findings suggest that

  20. Electronic Warfare (EW) Receiver and Processing Concepts Evaluation Program (RAPCEval 2)

    National Research Council Canada - National Science Library

    Bass, W

    1999-01-01

    .... Tasks initiated under OPTION 1 of the contract of this program provided analysis for inputs and countermeasures for electronic receivers of radar, electro-optic, infrared, and ultraviolet systems...

  1. Electronic Warfare (EW) Receiver and Processing Concepts Evaluation Program (RAPCEval2)

    National Research Council Canada - National Science Library

    Bass, W

    1999-01-01

    .... Tasks initiated under OPTION 1 of the contract of this program provided analysis for inputs and countermeasures for electronic receivers of radar, electro-optic, infrared, and ultraviolet systems...

  2. Connected vehicle pilot deployment program phase 1, security management operational concept : ICF/Wyoming.

    Science.gov (United States)

    2016-03-14

    The Wyoming Department of Transportations (WYDOT) Connected Vehicle (CV) Pilot Deployment Program is intended to develop a suite of applications that utilize vehicle to infrastructure (V2I) and vehicle to vehicle (V2V) communication technology to ...

  3. Connected vehicle pilot deployment program phase I : security management operational concept, Tampa Hillsborough Expressway Authority (THEA).

    Science.gov (United States)

    2016-05-01

    The Tampa Hillsborough Expressway Authority (THEA) Connected Vehicle (CV) Pilot Deployment Program is intended to develop a suite of applications that utilize vehicle to infrastructure (V2I) and vehicle to vehicle (V2V) communication technology to re...

  4. A Concept of Constructing a Common Information Space for High Tech Programs Using Information Analytical Systems

    Science.gov (United States)

    Zakharova, Alexandra A.; Kolegova, Olga A.; Nekrasova, Maria E.

    2016-04-01

    The paper deals with the issues in program management used for engineering innovative products. The existing project management tools were analyzed. The aim is to develop a decision support system that takes into account the features of program management used for high-tech products: research intensity, a high level of technical risks, unpredictable results due to the impact of various external factors, availability of several implementing agencies. The need for involving experts and using intelligent techniques for information processing is demonstrated. A conceptual model of common information space to support communication between members of the collaboration on high-tech programs has been developed. The structure and objectives of the information analysis system “Geokhod” were formulated with the purpose to implement the conceptual model of common information space in the program “Development and production of new class mining equipment - “Geokhod”.

  5. Physician practice responses to financial incentive programs: exploring the concept of implementation mechanisms.

    Science.gov (United States)

    Cohen, Genna R; Erb, Natalie; Lemak, Christy Harris

    2012-01-01

    To develop a framework for studying financial incentive program implementation mechanisms, the means by which physician practices and physicians translate incentive program goals into their specific office setting. Understanding how new financial incentives fit with the structure of physician practices and individual providers' work may shed some insight on the variable effects of physician incentives documented in numerous reviews and meta-analyses. Reviewing select articles on pay-for-performance evaluations to identify and characterize the presence of implementation mechanisms for designing, communicating, implementing, and maintaining financial incentive programs as well as recognizing participants' success and effects on patient care. Although uncommonly included in evaluations, evidence from 26 articles reveals financial incentive program sponsors and participants utilized a variety of strategies to facilitate communication about program goals and intentions, to provide feedback about participants' progress, and to assist-practices in providing recommended services. Despite diversity in programs' geographic locations, clinical targets, scope, and market context, sponsors and participants deployed common strategies. While these methods largely pertained to communication between program sponsors and participants and the provision of information about performance through reports and registries, they also included other activities such as efforts to engage patients and ways to change staff roles. This review covers a limited body of research to develop a conceptual framework for future research; it did not exhaustively search for new articles and cannot definitively link particular implementation mechanisms to outcomes. Our results underscore the effects implementation mechanisms may have on how practices incorporate new programs into existing systems of care which implicates both the potential rewards from small changes as well as the resources which may be

  6. PROGRAM ASTEC (ADVANCED SOLAR TURBO ELECTRIC CONCEPT). PART 1. CANDIDATE MATERIALS LABORATORY TESTS

    Science.gov (United States)

    A space power system of the type envisioned by the ASTEC program requires the development of a lightweight solar collector of high reflectance...capable of withstanding the space environment for an extended period. A survey of the environment of interest for ASTEC purposes revealed 4 potential...developed by the solar-collector industry for use in the ASTEC program, and to test the effects of space environment on these materials. Of 6 material

  7. Programmatic Environmental Scans: A Survey Based on Program Planning and Evaluation Concepts

    Directory of Open Access Journals (Sweden)

    Donna J. Peterson

    2015-10-01

    Full Text Available Within Extension, environmental scans are most commonly used to assess community or organizational issues or for strategic planning purposes. However, Extension has expanded the use of environmental scans to systematically identify “what programs exist” on a given topic or focus area. Yet, despite recent attention to the topic of environmental scanning in Extension, survey instruments used to conduct environmental scans have not been published. Given the emphasis on implementation of evidence-based practices and programs, having a ready-made survey that can be used to identify programs on a specific topic and that could subsequently lead to an evaluability assessment of those programs would be a useful resource. To encourage the use of environmental scans to identify existing evidence-based programs, this article describes a survey instrument developed for the purpose of scanning for 4-H Healthy Living programs ready for rigorous outcome evaluation and/or national replication. It focuses on the rationale for survey items, as well as provides a summary and definition of those items. The survey tool can be easily adapted for future programmatic environmental scans both within and outside Extension.

  8. Consolidated fuel-reprocessing program:: man/machine interface development for the REMOTEX concept

    International Nuclear Information System (INIS)

    Garin, J.; Clarke, M.M.

    1981-01-01

    This paper describes ongoing research at ORNL to develop a man/machine interface system that can be used to remotely control a system composed of a transporter base and a force-reflecting, servo-controlled manipulator. A unique feature of the concept is the incorporation of totally remote operation. Thus, a major objective is the requirement that an operator have a sense of presence in the remote environment. Man/machine interface requirements for this totally remote operation remain to be developed. Therefore, a simulator is being built to optimize such requirements and the developments are discussed

  9. Conception of programs for evaluating balance indices of operation of WWER-440 nuclear power plants

    International Nuclear Information System (INIS)

    Zadrazil, J.

    1986-01-01

    The procedures are discussed of writing computation programs for the evaluation of basic technical and economic parameters of the operation of WWER-440 nuclear power plants. The criterion of the evaluation is the maximum power supply to the grid together with the required supply of heat, with the observance of safe operating conditions. Previous procedures of evaluation are compared with present procedures based on the use of a monitoring and evaluation system of the KOMPLEX-URAN 2 M type. The mathematical model of the program is based on balance equations and relations derived for actual measuring systems and is completed with an assessment of the reliability of input and output data. The flow chart is shown of the algorithm for the evaluation of technical and economic parameters, and methods are suggested for improving and extending the program. (J.C.)

  10. When technology became language: the origins of the linguistic conception of computer programming, 1950-1960.

    Science.gov (United States)

    Nofre, David; Priestley, Mark; Alberts, Gerard

    2014-01-01

    Language is one of the central metaphors around which the discipline of computer science has been built. The language metaphor entered modern computing as part of a cybernetic discourse, but during the second half of the 1950s acquired a more abstract meaning, closely related to the formal languages of logic and linguistics. The article argues that this transformation was related to the appearance of the commercial computer in the mid-1950s. Managers of computing installations and specialists on computer programming in academic computer centers, confronted with an increasing variety of machines, called for the creation of "common" or "universal languages" to enable the migration of computer code from machine to machine. Finally, the article shows how the idea of a universal language was a decisive step in the emergence of programming languages, in the recognition of computer programming as a proper field of knowledge, and eventually in the way we think of the computer.

  11. Environmental assessment for the satellite power system concept development and evaluation program: nonmicrowave health and ecological effects

    Energy Technology Data Exchange (ETDEWEB)

    White, M R

    1980-11-01

    A Concept Development and Evaluation Program is being carried out for a proposed Satellite Power System (SPS). For purposes of this evaluation, a preliminary reference system has been developed. SPS, as described in the reference system, would collect solar energy on satellites in geosychronous orbit in space. The energy would be converted to microwaves and beamed to an earth-receiving antenna (rectenna). One task in the environmental part of the program is the assessment of the nonmicrowave effects on health and the environment. These effects would result from all phases of SPS development and operation. This report covers the current knowledge regarding these effects, and is based on the reference system. The assessment is summarized as to scope, methodology, impacts of terrestrial development, launch and recovery of spacecraft, space activities (including health effects of the space environment, ionizing radiation, electromagnetic exposure, spacecraft charging and environmental interactions, occupational hazards, etc.) and construction and operation of rectenna (ground receiving station).

  12. Environmental assessment for the satellite power system concept development and evaluation program: nonmicrowave health and ecological effects

    International Nuclear Information System (INIS)

    White, M.R.

    1980-11-01

    A Concept Development and Evaluation Program is being carried out for a proposed Satellite Power System (SPS). For purposes of this evaluation, a preliminary reference system has been developed. SPS, as described in the reference system, would collect solar energy on satellites in geosychronous orbit in space. The energy would be converted to microwaves and beamed to an earth-receiving antenna (rectenna). One task in the environmental part of the program is the assessment of the nonmicrowave effects on health and the environment. These effects would result from all phases of SPS development and operation. This report covers the current knowledge regarding these effects, and is based on the reference system. The assessment is summarized as to scope, methodology, impacts of terrestrial development, launch and recovery of spacecraft, space activities (including health effects of the space environment, ionizing radiation, electromagnetic exposure, spacecraft charging and environmental interactions, occupational hazards, etc.) and construction and operation of rectenna

  13. Selected concrete spent fuel storage cask concepts and the DOE/PSN Cooperative Cask Testing Program

    International Nuclear Information System (INIS)

    Creer, J.M.; McKinnon, M.A.; Collantes, C.E.

    1990-01-01

    To date, water pools, metal casks, horizontal concrete modules, and modular vaults have been used to store the major quantity of commercial light water reactor spent nuclear fuel. Recently, vertical concrete dry storage casks have received consideration for storage of spent nuclear fuel. This paper reviews the evolution of the development of selected vertical concrete dry storage casks and outlines a cooperative cask testing (heat transfer and shielding) program involving the US Department of Energy and Pacific Sierra Nuclear Associates. Others participating in the cooperative program are Pacific Northwest Laboratory; EG ampersand G Idaho, Inc.; Wisconsin Electric Power Company; and the Electric Power Research Institute. 28 refs., 14 figs

  14. Acute dietary zinc deficiency before conception compromises oocyte epigenetic programming and disrupts embryonic development.

    Science.gov (United States)

    Tian, X; Diaz, F J

    2013-04-01

    Recent findings show that zinc is an important factor necessary for regulating the meiotic cell cycle and ovulation. However, the role of zinc in promoting oocyte quality and developmental potential is not known. Using an in vivo model of acute dietary zinc deficiency, we show that feeding a zinc deficient diet (ZDD) for 3-5 days before ovulation (preconception) dramatically disrupts oocyte chromatin methylation and preimplantation development. There was a dramatic decrease in histone H3K4 trimethylation and global DNA methylation in zinc deficient oocytes. Moreover, there was a 3-20 fold increase in transcript abundance of repetitive elements (Iap, Line1, Sineb1, Sineb2), but a decrease in Gdf9, Zp3 and Figla mRNA. Only 53% and 8% of mature eggs reached the 2-cell stage after IVF in animals receiving a 3 and 5 days ZDD, respectively, while a 5 day ZDD in vivo reduced the proportion of 2-cells to 49%. In vivo fertilized 2-cell embryos cultured in vitro formed fewer (38%) blastocysts compared to control embryos (74%). Likewise, fewer blastocyst and expanded blastocyst were collected from the reproductive tract of zinc deficient animals on day 3.5 of pregnancy. This could be due to a decrease in Igf2 and H19 mRNA in ZDD blastocyst. Supplementation with a methyl donor (SAM) during IVM restored histone H3K4me3 and doubled the IVF success rate from 17% to 43% in oocytes from zinc deficient animals. Thus, the terminal period of oocyte development is extremely sensitive to perturbation in dietary zinc availability. Copyright © 2013 Elsevier Inc. All rights reserved.

  15. Airspace Systems Program: Next Generation Air Transportation System Concepts and Technology Development FY2010 Project Plan Version 3.0

    Science.gov (United States)

    Kopardekar, Parimal H.

    2010-01-01

    This document describes the FY2010 plan for the management and execution of the Next Generation Air Transportation System (NextGen) Concepts and Technology Development (CTD) Project. The document was developed in response to guidance from the Airspace Systems Program (ASP), as approved by the Associate Administrator of the Aeronautics Research Mission Directorate (ARMD), and from guidelines in the Airspace Systems Program Plan. Congress established the multi-agency Joint Planning and Development Office (JPDO) in 2003 to develop a vision for the 2025 Next Generation Air Transportation System (NextGen) and to define the research required to enable it. NASA is one of seven agency partners contributing to the effort. Accordingly, NASA's ARMD realigned the Airspace Systems Program in 2007 to "directly address the fundamental research needs of the Next Generation Air Transportation System...in partnership with the member agencies of the JPDO." The Program subsequently established two new projects to meet this objective: the NextGen-Airspace Project and the NextGen-Airportal Project. Together, the projects will also focus NASA s technical expertise and world-class facilities to address the question of where, when, how and the extent to which automation can be applied to moving aircraft safely and efficiently through the NAS and technologies that address optimal allocation of ground and air technologies necessary for NextGen. Additionally, the roles and responsibilities of humans and automation influence in the NAS will be addressed by both projects. Foundational concept and technology research and development begun under the NextGen-Airspace and NextGen-Airportal projects will continue. There will be no change in NASA Research Announcement (NRA) strategy, nor will there be any change to NASA interfaces with the JPDO, Federal Aviation Administration (FAA), Research Transition Teams (RTTs), or other stakeholders

  16. Long-term soil productivity: genesis of the concept and principles behind the program

    Science.gov (United States)

    Robert F. Powers

    2006-01-01

    The capacity of a forest site to capture carbon and convert it into biomass defines fundamental site productivity. In the United States, the National Forest Management Act (NFMA) of 1976 mandates that this capacity must be protected on federally managed lands. Responding to NFMA, the USDA Forest Service began a soil-based monitoring program for its managed forests....

  17. Hardware test program for evaluation of baseline range/range rate sensor concept

    Science.gov (United States)

    Pernic, E.

    1985-01-01

    The test program Phase II effort provides additional design information in terms of range and range rate (R/R) sensor performance when observing and tracking a typical spacecraft target. The target used in the test program was a one-third scale model of the Hubble Space Telescope (HST) available at the MSFC test site where the tests were performed. A modified Bendix millimeter wave radar served as the R/R sensor test bed for evaluation of range and range rate tracking performance, and generation of radar signature characteristics of the spacecraft target. A summary of program test results and conclusions are presented along with detailed description of the Bendix test bed radar with accompaning instrumentation. The MSFC test site and facilities are described. The test procedures used to establish background levels, and the calibration procedures used in the range accuracy tests and RCS (radar cross section) signature measurements, are presented and a condensed version of the daily log kept during the 5 September through 17 September test period is also presented. The test program results are given starting with the RCS signature measurements, then continuing with range measurement accuracy test results and finally the range and range rate tracking accuracy test results.

  18. The Organization as Client: Broadening the Concept of Employee Assistance Programs.

    Science.gov (United States)

    Googins, Bradley; Davidson, Bruce N.

    1993-01-01

    Notes that many employee assistance programs (EAPs) are broadening their function to address rapidly changing human and social issues of environments in which they operate, refocusing practice to include organization as the client. Discusses traditional EAP practice, evolution of EAPs, changes confronting corporations, and alternative model in…

  19. Sensor programming and concept implementation of a temperature monitoring system, using Arduino as prototyping platform

    DEFF Research Database (Denmark)

    Sbîrnă, Sebastian; Søberg, Peder Veng; Sbîrnă, Liana Simona

    2016-01-01

    The present work reports the programming paradigms that have been developed for a temperature monitoring system able to provide accurate data regarding food temperatures inside refrigerated vehicles and alert the driver accordingly, in relation to which temperature states are encountered. The men...

  20. Concept of Draft International Standard for a Unified Approach to Space Program Quality Assurance

    Science.gov (United States)

    Stryzhak, Y.; Vasilina, V.; Kurbatov, V.

    2002-01-01

    For want of the unified approach to guaranteed space project and product quality assurance, implementation of many international space programs has become a challenge. Globalization of aerospace industry and participation of various international ventures with diverse quality assurance requirements in big international space programs requires for urgent generation of unified international standards related to this field. To ensure successful fulfillment of space missions, aerospace companies should design and process reliable and safe products with properties complying or bettering User's (or Customer's) requirements. Quality of the products designed or processed by subcontractors (or other suppliers) should also be in compliance with the main user (customer)'s requirements. Implementation of this involved set of unified requirements will be made possible by creating and approving a system (series) of international standards under a generic title Space Product Quality Assurance based on a system consensus principle. Conceptual features of the baseline standard in this system (series) should comprise: - Procedures for ISO 9000, CEN and ECSS requirements adaptation and introduction into space product creation, design, manufacture, testing and operation; - Procedures for quality assurance at initial (design) phases of space programs, with a decision on the end product made based on the principle of independence; - Procedures to arrange incoming inspection of products delivered by subcontractors (including testing, audit of supplier's procedures, review of supplier's documentation), and space product certification; - Procedures to identify materials and primary products applied; - Procedures for quality system audit at the component part, primary product and materials supplier facilities; - Unified procedures to form a list of basic performances to be under configuration management; - Unified procedures to form a list of critical space product components, and unified

  1. Maturation arrest of human oocytes at germinal vesicle stage

    Directory of Open Access Journals (Sweden)

    Zhi Qin Chen

    2010-01-01

    Full Text Available Maturation arrest of human oocytes may occur at various stages of the cell cycle. A total failure of human oocytes to complete meiosis is rarely observed during assisted conception cycles. We describe here a case of infertile couples for whom all oocytes repeatedly failed to mature at germinal vesicle (GV stage during in vitro fertilization/Intra cytoplasmic sperm injection (IVF/ICSI. The patient underwent controlled ovarian stimulation followed by oocyte retrieval and IVF/ICSI. The oocytes were stripped off cumulus cells prior to the ICSI procedure and their maturity status was defined. The oocyte maturation was repeatedly arrested at the GV. Oocyte maturation arrest may be the cause of infertility in this couple. The recognition of oocyte maturation arrest as a specific medical condition may contribute to the characterization of the currently known as "oocyte factor." The cellular and genetic mechanisms causing oocyte maturation arrest should be the subject for further investigation.

  2. Generic concept to program the time domain of self-assemblies with a self-regulation mechanism.

    Science.gov (United States)

    Heuser, Thomas; Steppert, Ann-Kathrin; Lopez, Catalina Molano; Zhu, Baolei; Walther, Andreas

    2015-04-08

    Nature regulates complex structures in space and time via feedback loops, kinetically controlled transformations, and under energy dissipation to allow non-equilibrium processes. Although man-made static self-assemblies realize excellent control over hierarchical structures via molecular programming, managing their temporal destiny by self-regulation is a largely unsolved challenge. Herein, we introduce a generic concept to control the time domain by programming the lifetimes of switchable self-assemblies in closed systems. We conceive dormant deactivators that, in combination with fast promoters, enable a unique kinetic balance to establish an autonomously self-regulating, transient pH-state, whose duration can be programmed over orders of magnitude-from minutes to days. Coupling this non-equilibrium state to pH-switchable self-assemblies allows predicting their assembly/disassembly fate in time, similar to a precise self-destruction mechanism. We demonstrate a platform approach by programming self-assembly lifetimes of block copolymers, nanoparticles, and peptides, enabling dynamic materials with a self-regulation functionality.

  3. Philadelphia's community based drug abuse program: broader medical and social concepts.

    Science.gov (United States)

    Schut, J

    1975-06-01

    The rehabilitation of drug dependent people has undergone drastic changes since first attempts were made to curb the abuse of illegal drugs. The isolated law-enforcement model proved to be of no use in this area. So, too, the medical model, the psychological model and the public health model proved disappointingly low in their results. During the last ten years, a so-called "metabolic replacement model" has had its upsurge, creating a controversy still under discussion. The Drug Abuse Rehabilitation Programs of the West Philadelphia Community Mental Health Consortium, Inc. have been in the forefront with its treatment models. Established in 1968 as a purely methadone maintenance program, it has evolved into becoming a model, applying community mental health principles. This paper will explore this model further, describing the mechanics of its changes. From a municipal hospital-based methadone dispensing station, the program has developed into a multi-modality project. Three decentralized drug-free outpatient services are located in the midst of the community where the drug abuse problem is more accute. Outreach is emphasized and case-funding is applied. A possibly unique river-front motel was just acquired for the development of a community-based treatment modality. The 94 rooms were converted into a first-floor alcoholism program which also has a "highway safety program" and an intermediate care facility for alcoholics. The second floor of this facility contains outpatient services for the treatment of drug addicts, including a methadone maintenance program, counselling, family therapy and group therapy. The place where most of the emphasis has been placed is the Work Rehabilitation Center (a novel approach whereby patients will spend up to six hours in "partial hospitalization"). Clients will be tested for vocational aptitude and four workshops will be developed on the premises - carpentry, automotive, electricity and clerical. A huge cafeteria with a semi

  4. Advanced Transportation System Studies. Technical Area 3: Alternate Propulsion Subsystems Concepts. Volume 3; Program Cost Estimates

    Science.gov (United States)

    Levack, Daniel J. H.

    2000-01-01

    The objective of this contract was to provide definition of alternate propulsion systems for both earth-to-orbit (ETO) and in-space vehicles (upper stages and space transfer vehicles). For such propulsion systems, technical data to describe performance, weight, dimensions, etc. was provided along with programmatic information such as cost, schedule, needed facilities, etc. Advanced technology and advanced development needs were determined and provided. This volume separately presents the various program cost estimates that were generated under three tasks: the F- IA Restart Task, the J-2S Restart Task, and the SSME Upper Stage Use Task. The conclusions, technical results , and the program cost estimates are described in more detail in Volume I - Executive Summary and in individual Final Task Reports.

  5. Pediatric Obesity: It's Time for Prevention before Conception Can Maternal Obesity Program Pediatric Obesity?

    OpenAIRE

    Zach Ferraro; Kristi B. Adamo

    2008-01-01

    Global increases in obesity have led public health experts to declare this disease a pandemic. Although prevalent in all ages, the dire consequences associated with maternal obesity have a pronounced impact on the long-term health of their children as a result of the intergenerational effects of developmental programming. Previously, fetal under-nutrition has been linked to the predisposition to pediatric obesity explained by the adiposity rebound and ‘catch-up’ growth that occurs when a chil...

  6. A Blended Approach to Learning in an Obstetrics and Gynecology Residency Program: Proof of Concept

    Directory of Open Access Journals (Sweden)

    Funminiyi A. Taylor

    2015-01-01

    Full Text Available Problem Graduate medical education programs are expected to educate residents to be able to manage critically ill patients. Most obstetrics and gynecology (OB/GYN graduate medical education programs provide education primarily in a didactic format in a traditional face-to-face setting. Busy clinical responsibilities tend to limit resident engagement during these educational sessions. The revision of the training paradigm to a more learner-centered approach is suggested. Intervention A blended learning education program was designed and implemented to facilitate the teaching and learning of obstetric emergencies, specifically diabetic ketoacidosis and acute-onset severe hypertension in pregnancy. The program incorporated tools to foster a community of inquiry. Multimedia presentations were also utilized as the main modality to provide instruction. The blended learning course was designed in accordance with the cognitive theory of multimedia learning. Context This intervention was carried out in the Department of Obstetrics and Gynecology, Southern Illinois University. All 15 OB/GYN residents were enrolled in this course as part of their educational curriculum. First, face-to-face instructions were given in detail about the blended learning process, course content, and online website. The residents were then assigned tasks related to completing the online component of the course, including watching multimedia presentations, reading the resources placed online, and participating in online asynchronous discussions. The course culminated with a face-to-face session to clarify misconceptions. Pre- and postcourse quizzes were administered to the residents to assess their retention and understanding. Outcome Objective analysis demonstrated significant improvements in retention and understanding after participating in the course. The blended learning format was well received by the residents. Resident perception of social presence in the asynchronous

  7. Concept - or no concept

    DEFF Research Database (Denmark)

    Thorsteinsson, Uffe

    1999-01-01

    Discussion about concept in industrial companies. A method for mapping of managerial concept in specific area is shown......Discussion about concept in industrial companies. A method for mapping of managerial concept in specific area is shown...

  8. Governance for territorial development: from conception to action – the case of Para Rural Program

    Directory of Open Access Journals (Sweden)

    Sérgio Cardoso de Moraes

    2016-08-01

    Full Text Available It is to analyze the proposal of a public policy of Para State Government (GEP, as its design and actions, presents towards territorial development. In rural areas the Amazon of Para, the GEP has designed a public policy that aims to reduce poverty in poor rural ones. With loan agreement of resources between GEP and World Bank, the Para Rural Program, investing in productive projects without ordering the territory, having despised territorial governance processes that were one of his instruments, in which public policy is carried out in violation of importance of people and the environment which, projecting the policy, resulting interests of governments than of State.

  9. Conceptions of Contraceptive Use in Rural KwaZulu-Natal, South Africa: Lessons for Programming

    Science.gov (United States)

    Ndinda, Catherine; Ndhlovu, Tidings; Khalema, Nene Ernest

    2017-01-01

    Community family planning programmes in South Africa arose from the controversial apartheid history of controlling the African population while encouraging the growth of European migrant population. Post-apartheid population policies shifted away from population control to aligning policies to the global agenda that placed emphasis on the link between population and development. The focus on population and development polices in post-apartheid South Africa is on social equality, justice and peace rather than controlling sections of the population. Given the shift, this paper interrogates the conceptions of contraceptive use among rural communities in KwaZulu-Natal. Our primary objective is to understand the dynamics surrounding access to and use of family planning services in peri-urban and rural areas of KwaZulu-Natal. Using focus group data, the findings of the study suggest that different social categories interact with the family planning programmes differently. How teenagers and married women perceive the value of family planning differs. Gender differences regarding the use of condoms are also evident. The paper attempts to grapple with the non-use of condoms despite the knowledge that these prevent pregnancy and provide protection from sexually-transmitted diseases. The contribution of this paper lies in its identification of socio-cultural factors and the political economy underlying the different attitudes towards contraceptive use in rural KwaZulu-Natal. PMID:28350334

  10. Conceptions of Contraceptive Use in Rural KwaZulu-Natal, South Africa: Lessons for Programming.

    Science.gov (United States)

    Ndinda, Catherine; Ndhlovu, Tidings; Khalema, Nene Ernest

    2017-03-28

    Community family planning programmes in South Africa arose from the controversial apartheid history of controlling the African population while encouraging the growth of European migrant population. Post-apartheid population policies shifted away from population control to aligning policies to the global agenda that placed emphasis on the link between population and development. The focus on population and development polices in post-apartheid South Africa is on social equality, justice and peace rather than controlling sections of the population. Given the shift, this paper interrogates the conceptions of contraceptive use among rural communities in KwaZulu-Natal. Our primary objective is to understand the dynamics surrounding access to and use of family planning services in peri-urban and rural areas of KwaZulu-Natal. Using focus group data, the findings of the study suggest that different social categories interact with the family planning programmes differently. How teenagers and married women perceive the value of family planning differs. Gender differences regarding the use of condoms are also evident. The paper attempts to grapple with the non-use of condoms despite the knowledge that these prevent pregnancy and provide protection from sexually-transmitted diseases. The contribution of this paper lies in its identification of socio-cultural factors and the political economy underlying the different attitudes towards contraceptive use in rural KwaZulu-Natal.

  11. The use of maturity method in estimating concrete strength

    International Nuclear Information System (INIS)

    Salama, A.E.; Abd El-Baky, S.M.; Ali, E.E.; Ghanem, G.M.

    2005-01-01

    Prediction of the early age strength of concrete is essential for modernized concrete for construction as well as for manufacturing of structural parts. Safe and economic scheduling of such critical operations as form removal and re shoring, application of post-tensioning or other mechanical treatment, and in process transportation and rapid delivery of products all should be based upon a good grasp of the strength development of the concrete in use. For many years, it has been proposed that the strength of concrete can be related to a simple mathematical function of time and temperature so that strength could be assessed by calculation without mechanical testing. Such functions are used to compute what is called the m aturity o f concrete, and the computed value is believed to obtain a correlation with the strength of concrete. With its simplicity and low cost, the application of maturity concept as in situ testing method has received wide attention and found its use in engineering practice. This research work investigates the use of M aturity method' in estimating the concrete strength. An experimental program is designed to estimate the concrete strength by using the maturity method. Using different concrete mixes, with available local materials. Ordinary Portland Cement, crushed stone, silica fume, fly ash and admixtures with different contents are used . All the specimens were exposed to different curing temperatures (10, 25 and 40 degree C), in order to get a simplified expression of maturity that fits in with the influence of temperature. Mix designs and charts obtained from this research can be used as guide information for estimating concrete strength by using the maturity method

  12. Adult maturational processes and the facilitating environment.

    Science.gov (United States)

    Acklin, M W

    1986-09-01

    The psychoanalytic theory of religion has been seriously limited in its development, largely owing to Freud's emphasis on religion's neurotic elements and an overemphasis on the infantile origins of religious development. This paper offers a conceptual framework and advances the thesis, based on contemporary psychoanalytic, developmental theory, that 1) Erikson's concept of epigenesis has applicability across the life span; 2) that beyond-the-self identity is constituent to human maturation and self-completion; 3) that successful adult maturation requires a mirroring-facilitating environment; and 4) that religious values, meanings, images, and communities play an essential role-as-elements of the facilitating environment of later life.

  13. A workshop on asthma management programs and centers in Brazil: reviewing and explaining concepts*

    Science.gov (United States)

    Stelmach, Rafael; Neto, Alcindo Cerci; Fonseca, Ana Cristina de Carvalho Fernandez; Ponte, Eduardo Vieira; Alves, Gerardo; Araujo-Costa, Ildely Niedia; Lasmar, Laura Maria de Lima Belizário Facury; de Castro, Luci Keiko Kuromoto; Lenz, Maria Lucia Medeiros; Silva, Paulo; Cukier, Alberto; Alves, Alexssandra Maia; Lima-Matos, Aline Silva; Cardoso, Amanda da Rocha Oliveira; Fernandes, Ana Luisa Godoy; de São-José, Bruno Piassi; Riedi, Carlos Antônio; Schor, Deborah; Peixoto, Décio Medeiros; Brandenburg, Diego Djones; Camillo, Elineide Gomes dos Santos; Serpa, Faradiba Sarquis; Brandão, Heli Vieira; Lima, João Antonio Bonfadini; Pio, Jorge Eduardo; Fiterman, Jussara; Anderson, Maria de Fátima; Cardoso, Maria do Socorro de Lucena; Rodrigues, Marcelo Tadday; Pereira, Marilyn Nilda Esther Urrutia; Antila, Marti; Martins, Sonia Maria; Guimarães, Vanessa Gonzaga Tavares; Mello, Yara Arruda Marques; de Andrade, Wenderson Clay Correia; Salibe-Filho, William; Caldeira, Zelina Maria da Rocha; da Cruz-Filho, Álvaro Augusto Souza; Camargos, Paulo

    2015-01-01

    Objective: To report the results of a workshop regarding asthma management programs and centers (AMPCs) in Brazil, so that they can be used as a tool for the improvement and advancement of current and future AMPCs. Methods: The workshop consisted of five presentations and the corresponding group discussions. The working groups discussed the following themes: implementation of asthma management strategies; human resources needed for AMPCs; financial resources needed for AMPCs; and operational maintenance of AMPCs. Results: The workshop involved 39 participants, from all regions of the country, representing associations of asthma patients (n = 3), universities (n = 7), and AMPCs (n = 29). We found a direct relationship between a lack of planning and the failure of AMPCs. Based on the experiences reported during the workshop, the common assumptions about AMPCs in Brazil were the importance of raising awareness of managers; greater community participation; interdependence between primary care and specialized care; awareness of regionalization; and use of medications available in the public health system. Conclusions: Brazil already has a core of experience in the area of asthma management programs. The implementation of strategies for the management of chronic respiratory disease and their incorporation into health care system protocols would seem to be a natural progression. However, there is minimal experience in this area. Joint efforts by individuals with expertise in AMPCs could promote the implementation of asthma management strategies, thus speeding the creation of treatment networks, which might have a multiplier effect, precluding the need for isolated centers to start from zero. PMID:25750669

  14. Applying Monte Carlo Concept and Linear Programming in Modern Portfolio Theory to Obtain Best Weighting Structure

    Directory of Open Access Journals (Sweden)

    Tumpal Sihombing

    2013-01-01

    Full Text Available The world is entering the era of recession when the trend is bearish and market is not so favorable. The capital markets in every major country were experiencing great amount of loss and people suffered in their investment. The Jakarta Composite Index (JCI has shown a great downturn for the past one year but the trend bearish year of the JCI. Therefore, rational investors should consider restructuring their portfolio to set bigger proportion in bonds and cash instead of stocks. Investors can apply modern portfolio theory by Harry Markowitz to find the optimum asset allocation for their portfolio. Higher return is always associated with higher risk. This study shows investors how to find out the lowest risk of a portfolio investment by providing them with several structures of portfolio weighting. By this way, investor can compare and make the decision based on risk-return consideration and opportunity cost as well. Keywords: Modern portfolio theory, Monte Carlo, linear programming

  15. MSR - SPHINX concept program Eros (Experimental zero power Salt reactor SR-0) - The proposed experimental program as a basis for validation of reactor physics methods

    Energy Technology Data Exchange (ETDEWEB)

    Hron, M.; Juricek, V.; Kyncl, J.; Mikisek, M.; Rypar, V. [Nuclear Research Institute Rez plc, Rez (Czech Republic)

    2007-07-01

    The Molten Salt Reactor (MSR) - SPHINX (SPent Hot fuel Incinerator by Neutron fluX) concept solves this principal problem of spent fuel treatment by means of so-called nuclear incineration. It means the burning of fissionable part of its inventory and transmutation of other problematic radionuclides by use of nuclear reactions with neutrons in a MSR-SPHINX system. This reactor system is an actinide burner (most in resonance neutron spectrum) and a radionuclide transmuter in a well-thermalized neutron spectrum. In the frame of the physical part, there are computational analyses and experimental activities. The experimental program has been focused, in its first stage, on a short-term irradiation of small size samples of molten-salt systems as well as structural materials proposed for the MSR blanket in the field of high neutron flux of research reactors. The proposed next stage of the program will focus on a large-scale experimental verification of design inputs by use of MSR-type inserting zones into the existing light water moderated experimental reactor LR-0, which may allow us to modify it into the experimental zero power salt reactor SR-0. There will be a detail description of the proposed program given in the paper together with the so far performed experiments and their first results. These realized experiments help us also to verify computational codes used, and to recognize some anomalies related to molten fluorides utilization. (authors)

  16. A Comparison of Two Low-Stakes Methods for Administering a Program-Level Biology Concept Assessment.

    Science.gov (United States)

    Couch, Brian A; Knight, Jennifer K

    2015-12-01

    Concept assessments are used commonly in undergraduate science courses to assess student learning and diagnose areas of student difficulty. While most concept assessments align with the content of individual courses or course topics, some concept assessments have been developed for use at the programmatic level to gauge student progress and achievement over a series of courses or an entire major. The broad scope of a program-level assessment, which exceeds the content of any single course, creates several test administration issues, including finding a suitable time for students to take the assessment and adequately incentivizing student participation. These logistical considerations must also be weighed against test security and the ability of students to use unauthorized resources that could compromise test validity. To understand how potential administration methods affect student outcomes, we administered the Molecular Biology Capstone Assessment (MBCA) to three pairs of matched upper-division courses in two ways: an online assessment taken by students outside of class and a paper-based assessment taken during class. We found that overall test scores were not significantly different and that individual item difficulties were highly correlated between these two administration methods. However, in-class administration resulted in reduced completion rates of items at the end of the assessment. Taken together, these results suggest that an online, outside-of-class administration produces scores that are comparable to a paper-based, in-class format and has the added advantages that instructors do not have to dedicate class time and students are more likely to complete the entire assessment.

  17. Environmentally Friendly Replacement of Mature 200 MW Coal-Fired Power Blocks with 2 Boilers Working on One 500 MW Class Steam Turbine Generator (2on1 Unit Concept)

    Science.gov (United States)

    Grzeszczak, Jan; Grela, Łukasz; Achter, Thomas

    2017-12-01

    The paper covers problems of the owners of a fleet of long-operated conventional power plants that are going to be decommissioned soon in result of failing to achieve new admissible emissions levels or exceeding pressure elements design lifetime. Energoprojekt-Katowice SA, Siemens AG and Rafako SA presents their joint concept of the solution which is a 2on1 concept - replacing two unit by two ultra-supercritical boilers feeding one turbine. Polish market has been taken as an example.

  18. The value of a mature, stable, and transparent regulatory framework in facilitating ER programs lessons learned in decommissioning of uranium recovery and other facilities in the USA - 59411

    International Nuclear Information System (INIS)

    McConnell, Keith I.; Camper, Larry

    2012-01-01

    Document available in abstract form only. Full text of publication follows: The history of decommissioning activities in the United States has demonstrated the value of a mature, stable and transparent regulatory framework in facilitating the timely completion of environmental remediation. Two examples are given as case studies. The first example relates to the history of uranium concentrate (yellowcake) production in the U.S. to support the initial development of civilian nuclear power in the U.S. in the 1950's, 60's, 70's and 80's. This yellowcake production, which took place mostly in the western U.S., was undertaken before laws and regulations to prevent contamination and protect public health and safety were fully developed. Significant contamination occurred in terms of both surface and ground water contamination. Although most conventional mills producing uranium during these early years entered decommissioning in the 70's and 80's, the vast majority are still remediating their sites because of persistent contamination in ground water. Had an effective regulatory framework been in place, much of this contamination would have been prevented and remediation accomplished more effectively. In contrast to this experience, a second example is provided related to development of the regulatory framework for decommissioning of non-uranium recovery facilities in the U.S. in the late 1990's and early 2000's

  19. Web‐based interactive learning programs for dentistry concept and its evaluation

    Directory of Open Access Journals (Sweden)

    Jitka Feberová

    2013-06-01

    Full Text Available The change in pedagogy relates partly to the development of electronic media and communication possibilities that are available in networked environments. This new technology dominates and supports the international educational content and learning. The aim of our study was to evaluate this progress in dental edu­cation. The education was compared parallel in two groups of Czech and international students. Groups and teaching hours were in the fourth year of the MD curriculum. Stomatology course materials were prepared and published on the portals of the individual dental study programs (http://dl.cuni.cz. The lectures had different access levels, ranging from materials that were freely available to all International WEB dental faculties’ sources to materials that were accessible only after receiving permission from the authors. A number of software tools were used for the creation of ­e-learning courses, such as, e.g., WebCT, Blackboard, Adobe Connect or Microsoft Class Server. The 291 students who were included in our study were divided into two groups according to the ­e-learning program. The goal of our study was to check student activities during the educational process, namely online work – lessons, articles, videos, lite­rature, quizzes and direct Internet access. The statisticaly significant differences were found in the results of the questionnaire based on five-point Likert scale. The Mann Whitney non-parametric test was used to evaluate students’ activities during the edu­cation process. The ­e-learning course had a direct influence on learning experiences, dental information, opinions and comments. Our results verified that satisfaction is an important and influential factor in determining whether a student decides to choose a dentistry and maxillofacial surgery course. Students prefer to have more time for practical therapy in the clinic. It was demonstrated that examination results did not correspond to the type of

  20. A multimedia adult literacy program: Combining NASA technology, instructional design theory, and authentic literacy concepts

    Science.gov (United States)

    Willis, Jerry W.

    1993-01-01

    be the most effective or most desirable way to use computer technology in literacy programs. This project is developing a series of instructional packages that are based on a different instructional model - authentic instruction. The instructional development model used to create these packages is also different. Instead of using the traditional five stage linear, sequential model based on behavioral learning theory, the project uses the recursive, reflective design and development model (R2D2) that is based on cognitive learning theory, particularly the social constructivism of Vygotsky, and an epistemology based on critical theory. Using alternative instructional and instructional development theories, the result of the summer faculty fellowship is LiteraCity, a multimedia adult literacy instructional package that is a simulation of finding and applying for a job. The program, which is about 120 megabytes, is distributed on CD-ROM.

  1. Pediatric Obesity: It's Time for Prevention before Conception Can Maternal Obesity Program Pediatric Obesity?

    Directory of Open Access Journals (Sweden)

    Zach Ferraro

    2008-01-01

    Full Text Available Global increases in obesity have led public health experts to declare this disease a pandemic. Although prevalent in all ages, the dire consequences associated with maternal obesity have a pronounced impact on the long-term health of their children as a result of the intergenerational effects of developmental programming. Previously, fetal under-nutrition has been linked to the predisposition to pediatric obesity explained by the adiposity rebound and ‘catch-up’ growth that occurs when a child born to a nutrient deprived mother is exposed to the obesogenic environment of present day. Given the recent increase in maternal overweight/obesity (OW/OB our attention has shifted from nutrient restriction to overabundance and excess during pregnancy. Consideration must now be given to interventions that could mitigate pregravid body mass index (BMI, attenuate gestational weight gain (GWG and reduce postpartum weight retention (PPWR in an attempt to prevent the downstream signaling of pediatric obesity and halt the intergenerational cycle of weight related disease currently plaguing our world. Thus, this paper will briefly review current research that best highlights the proposed mechanisms responsible for the development of child OW/OB and related sequalae (e.g. type II diabetes (T2D and cardiovascular disease (CVD resulting from maternal obesity.

  2. Long Maturity Forward Rates

    DEFF Research Database (Denmark)

    Christiansen, Charlotte

    2001-01-01

    The paper aims to improve the knowledge of the empirical properties of the long maturity region of the forward rate curve. Firstly, the theoretical negative correlation between the slope at the long end of the forward rate curve and the term structure variance is recovered empirically and found...... to be statistically significant. Secondly, the expectations hypothesis is analyzed for the long maturity region of the forward rate curve using "forward rate" regressions. The expectations hypothesis is numerically close to being accepted but is statistically rejected. The findings provide mixed support...... for the affine term structure model....

  3. The Role of Geochemistry and Basin Modelling in the Exploration of Mature province

    International Nuclear Information System (INIS)

    Katz, A.J.

    2002-01-01

    Petroleum geochemistry and basin modelling has been an important tool in the reduction of risks in poorly explored basins. Historically the role of geochemistry is usually reduced once production is established and often in mature province is nonexistent. However, attempts to add reserves in mature provinces require an expansion of exploration programs based on new play concepts. Consequently, there is a clear role for geochemistry and basin modelling as this revitalization occurs.These new basin modelling and geochemical programs are aimed at answering three questions: . Can the petroleum system be extended? . Is a change in hydrocarbon character to be expected? . How much hydrocarbon potential remains?Unlike frontier exploration a significant sample base is normally available that can be used to more effectively constrain interpretations. Such programs have clearly aided exploration in the Niger Delta. For example, the collection of an extensive piston core dataset in conjunction with a basin modelling program provided strong support for the Niger Delta's petroleum system extending into deep water areas. While the geochemical character of the oils established the presence of multiple effective generative systems, each of which has different source characteristics and often-different ages. This information constraints model construction and hydrocarbon volume estimates. Oil data also established the importance of phase segregation. The presence of fractionated oils and maturation modelling results provides evidence for deeper hydrocarbon potential within the geographic limits of established hydrocarbon pays

  4. Cross-country discrepancies on public understanding of stress concepts: evidence for stress-management psychoeducational programs.

    Science.gov (United States)

    Souza-Talarico, Juliana Nery; Wan, Nathalie; Santos, Sheila; Fialho, Patrícia Paes Araujo; Chaves, Eliane Corrêa; Caramelli, Paulo; Bianchi, Estela Ferraz; Santos, Aline Talita; Lupien, Sonia J

    2016-06-03

    Negative effects of stress have pose one of the major threats to the health and economic well being of individuals independently of age and cultural background. Nevertheless, the term "stress" has been globally used unlinked from scientificevidence-based meaning. The discrepancies between scientific and public stress knowledge are focus of concern and little is know about it. This is relevant since misconceptions about stress may influence the effects of stress-management psychoeducational programs and the development of best practices for interventions. The study aimed to analyze stress knowledge among the Canadian and Brazilian general public and to determine the extent to which scientific and popular views of stress differ between those countries. We evaluated 1156 healthy participants between 18 and 88 years of age recruited from Canada (n = 502) and Brazil (n = 654). To assess stress knowledge, a questionnaire composed of questions regarding stress concepts ("stress is bad" versus "stress-free life is good") and factors capable of triggering the stress response ("novelty, unpredictability, low sense of control and social evaluative threat versus "time pressure,work overload, conflict, unbalance and children") was used. Both Canadian and Brazilian participants showed misconceptions about stress and the factors capable of triggering a stress response. However, the rate of misconceptions was higher in Brazil than in Canada (p stress science and its variance according to a country's society. Psychoeducational programs and vulnerability of stress-related disorder are discussed.

  5. Breeding of cocksfoot cultivars with different maturity

    Directory of Open Access Journals (Sweden)

    Babić Snežana

    2017-01-01

    Full Text Available One of the most important criteria in breeding process of perennial grasses is maturity. Cultivars with different maturity play a very important role in utilization of perennial grasses, by providing the ability to create a mixture of different aspects utilization and time. The first grass species in Serbia whose breeding program involved this criterion was cocksfoot (Dactylis glomerata L.. In general cocksfoot is early to medium-early in maturity in comparison with other grasses and legumes, and that is mayor problem since in the optimum phase for cutting, cocksfoot is often earlier then other species in mixtures. As a result of this work, in the previous period, two cultivars of different maturity were released, Kruševačka 24 (K-24 and Kruševačka 25 (K-25. K-24 is medium and K-25 is late in maturity. New material is adapted to local agro-ecological conditions and productive in the same time. In breeding process of both cultivars initial material originated from autochthonous populations collected in eastern and central Serbia. Material from the wild flora is selected based on medium and late maturity which is already adapted and has good productivity. We applied the standard method of phenotypic recurrent selection with the creation of synthetic varieties by polycross.

  6. Grammar Maturity Model

    NARCIS (Netherlands)

    Zaytsev, V.; Pierantonio, A.; Schätz, B.; Tamzalit, D.

    2014-01-01

    The evolution of a software language (whether modelled by a grammar or a schema or a metamodel) is not limited to development of new versions and dialects. An important dimension of a software language evolution is maturing in the sense of improving the quality of its definition. In this paper, we

  7. Maturing interorganisational information systems

    NARCIS (Netherlands)

    Plomp, M.G.A.|info:eu-repo/dai/nl/313946809

    2012-01-01

    This thesis consists of nine chapters, divided over five parts. PART I is an introduction and the last part contains the conclusions. The remaining, intermediate parts are: PART II: Developing a maturity model for chain digitisation. This part contains two related studies concerning the development

  8. Jealousy and Moral Maturity.

    Science.gov (United States)

    Mathes, Eugene W.; Deuger, Donna J.

    Jealousy may be perceived as either good or bad depending upon the moral maturity of the individual. To investigate this conclusion, a study was conducted testing two hypothesis: a positive relationship exists between conventional moral reasoning (reference to norms and laws) and the endorsement and level of jealousy; and a negative relationship…

  9. Maturity Model for Advancing Smart Grid Interoperability

    Energy Technology Data Exchange (ETDEWEB)

    Knight, Mark; Widergren, Steven E.; Mater, J.; Montgomery, Austin

    2013-10-28

    Abstract—Interoperability is about the properties of devices and systems to connect and work properly. Advancing interoperability eases integration and maintenance of the resulting interconnection. This leads to faster integration, lower labor and component costs, predictability of projects and the resulting performance, and evolutionary paths for upgrade. When specifications are shared and standardized, competition and novel solutions can bring new value streams to the community of stakeholders involved. Advancing interoperability involves reaching agreement for how things join at their interfaces. The quality of the agreements and the alignment of parties involved in the agreement present challenges that are best met with process improvement techniques. The GridWise® Architecture Council (GWAC) sponsored by the United States Department of Energy is supporting an effort to use concepts from capability maturity models used in the software industry to advance interoperability of smart grid technology. An interoperability maturity model has been drafted and experience is being gained through trials on various types of projects and community efforts. This paper describes the value and objectives of maturity models, the nature of the interoperability maturity model and how it compares with other maturity models, and experiences gained with its use.

  10. Altruism and mature care: some rival moral considerations in care ethics.

    Science.gov (United States)

    Hem, Marit Helene; Halvorsen, Kristin; Nortvedt, Per

    2014-11-01

    We discuss Carol Gilligan's original concept of mature care in the light of the altruistic approach to caring and good clinical judgment. In particular, we highlight how the concept of mature care can capture important challenges in today's nursing. Further, we illuminate how mature care might differ normatively from an altruistic approach to caring and the traditional prudential virtues in nursing. We also discuss similarities between mature care and virtue ethics. For nursing and nurses' identity, in today's health care system that is increasingly pressured to 'produce' health, we believe it is important to both developing further theories on mature care and having normative discussions about care. © The Author(s) 2014.

  11. Development and maturity of the safety case: an international perspective from the nea secretariat

    International Nuclear Information System (INIS)

    2008-01-01

    This section describes the evolution and development of the concept of the safety case, provides some perspective on the maturity of the concept in practice, and highlights key outcomes and conclusions of the symposium. (author)

  12. mHealth medication and blood pressure self-management program in Hispanic hypertensives: a proof of concept trial

    Directory of Open Access Journals (Sweden)

    Sieverdes JC

    2013-10-01

    Full Text Available John C Sieverdes,1 Mathew Gregoski,1 Sachin Patel,1 Deborah Williamson,1 Brenda Brunner-Jackson,1 Judith Rundbaken,1 Eveline Treiber,1 Lydia Davidson,1 Frank A Treiber1,21Technology Applications Center for Healthful Lifestyles, College of Nursing, 2College of Medicine, Medical University of South Carolina, Charleston, SC, USAAbstract: Patient nonadherence to medication regimens and provider therapeutic inertia (failure to respond in timely manner to clinical data are two primary contributors to ineffective chronic disease management. This 3-month proof of concept trial used an iterative design approach guided by self-determination theory and the technology acceptance model to develop a culturally sensitive, patient-centered, and provider-centered mobile health medication and blood pressure self-management program. Cellular connected electronic medication trays provided reminder signals for patients to take medications and smartphone messaging reminded patients to take at-home blood pressures using a Bluetooth-enabled monitor. Providers were given bimonthly feedback. Motivational and reinforcement text and audio messages were sent based upon medication adherence rates and blood pressure levels. Ten Hispanics with uncontrolled essential hypertension were randomized to standard care and Smartphone Medication Adherence Stops Hypertension (SMASH intervention groups. Primary outcomes of provider and patient acceptability of the program were found to be high. Retention rates for the 3-month program were 100%, with mean ± standard deviation overall medication adherence for the SMASH group at 97.2% ± 2.8%, with all strongly believing the program helped them remember to take their medication. SMASH participants measured their blood pressure every 3 days 83.2% ± 6.0% of the time and completed 89.2% ± 19.06% of the expected readings. Nonparametric tests showed statistical significance for resting blood pressure changes between groups at months 2 (P = 0

  13. The ASLOTS concept: An interactive, adaptive decision support concept for Final Approach Spacing of Aircraft (FASA). FAA-NASA Joint University Program

    Science.gov (United States)

    Simpson, Robert W.

    1993-01-01

    This presentation outlines a concept for an adaptive, interactive decision support system to assist controllers at a busy airport in achieving efficient use of multiple runways. The concept is being implemented as a computer code called FASA (Final Approach Spacing for Aircraft), and will be tested and demonstrated in ATCSIM, a high fidelity simulation of terminal area airspace and airport surface operations. Objectives are: (1) to provide automated cues to assist controllers in the sequencing and spacing of landing and takeoff aircraft; (2) to provide the controller with a limited ability to modify the sequence and spacings between aircraft, and to insert takeoffs and missed approach aircraft in the landing flows; (3) to increase spacing accuracy using more complex and precise separation criteria while reducing controller workload; and (4) achieve higher operational takeoff and landing rates on multiple runways in poor visibility.

  14. 76 FR 21789 - ITS Joint Program Office; Vehicle to Infrastructure Core System Concept of Operations; Notice of...

    Science.gov (United States)

    2011-04-18

    ... Concept of Operations; Notice of Public Meeting AGENCY: Research and Innovative Technology Administration...) Core System Concept of Operations on May 17, 2011 at the Detroit Metro Airport Marriott, 30559 Flynn... to work originally performed under the Vehicle Infrastructure Integration Proof of Concept (VII POC...

  15. The forensic float nurse: a new concept in the effective management of service delivery in a forensic program.

    Science.gov (United States)

    Cyr, J J; Paradis, J

    2012-12-01

    A major challenge faced by Forensic Program management teams is to balance their budgets due to the unpredictability of the forensic patient population, particularly in the context of managing staffing costs where the hospital is not the "gatekeeper" and does not have control over who is admitted and when. In forensic mental health, the justice system, either via the courts, or review boards, determines who is ordered for admission to hospital for assessment or treatment and rehabilitation. Hospitals have little, if any, recourse but to admit these mentally disordered offenders. This typically results in increased levels of staffing with concomitant overtime costs. The literature suggests that clustered float pool nurses develop enhanced relationships with staff and patients, thereby enabling them to attain specialized clinical expertise to treat specific patient populations, promoting safer, high quality care, and overall are more cost effective. Forensic nursing is recognized as a mental health subspecialty. The "Forensic Float Nurse" concept was piloted to provide readily available, highly adaptable, skilled forensic nurses to assist in times of unpredictably heavy workloads and/or unplanned staffing shortages. A significant reduction approaching 50% in overtime was achieved. Heuristic implications of this finding are presented. © 2012 International Association of Forensic Nurses.

  16. The maturity of Nuclear Law

    International Nuclear Information System (INIS)

    Martinez Favini, J.A.

    1985-01-01

    The ever-increasing use of atomic energy since 1950 has generated a set of rules called for practical reasons Nuclear Law. This branch of law covers a wide scope of related activities and, specialized studies have apparently foreseen all conceivable hypotheses. The international character of Nuclear Law explains the basic harmony of international legislation. The methods of comparative Law and International Private Law as well as the joint, indepth work of scientists and jurists will bring about steady progress towards legislative unity and prompt solution to conflicts. The expectable revitalization of nuclear-electric programs early in the 21st. century will give rise to a Nuclear juridical community which can already be perceived through the maturity Nuclear Law has reached. (Author) [es

  17. People Capability Maturity Model. SM.

    Science.gov (United States)

    1995-09-01

    tailored so it consumes less time and resources than a traditional software process assessment or CMU/SEI-95-MM-02 People Capability Maturity Model...improved reputation or customer loyalty. CMU/SEI-95-MM-02 People Capability Maturity Model ■ L5-17 Coaching Level 5: Optimizing Activity 1...Maturity Model CMU/SEI-95-MM-62 Carnegie-Mellon University Software Engineering Institute DTIC ELECTE OCT 2 7 1995 People Capability Maturity

  18. Maturity effects in energy futures

    Energy Technology Data Exchange (ETDEWEB)

    Serletis, Apostolos (Calgary Univ., AB (CA). Dept. of Economics)

    1992-04-01

    This paper examines the effects of maturity on future price volatility and trading volume for 129 energy futures contracts recently traded in the NYMEX. The results provide support for the maturity effect hypothesis, that is, energy futures prices to become more volatile and trading volume increases as futures contracts approach maturity. (author).

  19. Antibody affinity maturation

    DEFF Research Database (Denmark)

    Skjødt, Mette Louise

    Yeast surface display is an effective tool for antibody affinity maturation because yeast can be used as an all-in-one workhorse to assemble, display and screen diversified antibody libraries. By employing the natural ability of yeast Saccharomyces cerevisiae to efficiently recombine multiple DNA...... laboratory conditions. A particular emphasis was put on using molecular techniques in conjunction with microenvironmental measurements (O2, pH, irradiance), a combination that is rarely found but provides a much more detailed understanding of “cause and effect” in complex natural systems...

  20. Increased height standard deviation scores in response to growth hormone therapy to near-adult height in older children with delayed skeletal maturation: results from the ANSWER Program.

    Science.gov (United States)

    Ross, Judith L; Lee, Peter A; Gut, Robert; Germak, John

    2015-01-01

    A primary goal of recombinant human growth hormone therapy (GHT) in children is attaining normal adult height. In this study, children with growth hormone deficiency (GHD) (including isolated idiopathic growth hormone deficiency [IGHD] and multiple pituitary hormone deficiency [MPHD]), idiopathic short stature (ISS), and Turner syndrome (TS) were evaluated for near-adult height (NAH) and percent achieving NAH within the normal range after approximately 4 years of GHT. Data from the American Norditropin® Web-Enabled Research (ANSWER) Program were analyzed for NAH from age at treatment start (ATS) (i.e., referral age as defined by age at enrollment in the study) to last clinic visit using one of the following two criteria: 1) age ≥18 years, or 2) if male: ≥16 years and height velocity (HV) standard deviation score (HSDS) ≤ -2, and either GHD (n = 201), ISS (n = 19), or TS (n = 41). The main outcome measures included HSDS and corrected HSDS (HSDS-target HSDS) in response to GH treatment, and correlation of ATS with NAH HSDS. Mean (± SD) chronological and bone ages at baseline were 14.0 ± 2.1 years and 11.7 ± 2.0 years, respectively, and mean GHT duration was 4.0 ± 1.6 years. Mean HSDS (baseline to NAH; GHD: -2.7 to -1.0; ISS: -2.8 to -1.4; TS: -3.0 to -1.8) and mean corrected HSDS (baseline to NAH; GHD: -2.1 to -0.3; ISS: -2.1 to -0.6; TS: -1.8 to -0.6) increased across diagnostic indications. Percentages of patients reaching near-adult HSDS > -2 were GHD: 87.6%; ISS: 78.9%; TS: 65.8%. Significant negative correlations were found between ATS and NAH HSDS when analyzed by sex. Despite a relatively advanced childhood age, the majority of GH-treated patients attained mean near-adult HSDS within the normal range (HSDS > -2). Negative correlations of ATS with near-adult HSDS indicate that an earlier age at treatment start would likely have resulted in greater adult height achieved in both male and female patients.

  1. Conformal Ablative Thermal Protection System for Planetary and Human Exploration Missions: Overview of the Technology Maturation Efforts Funded by NASA's Game Changing Development Program

    Science.gov (United States)

    Beck, Robin A.; Arnold, James O.; Gasch, Matthew J.; Stackpoole, Margaret M.; Fan, Wendy; Szalai, Christine E.; Wercinski, Paul F.; Venkatapathy, Ethiraj

    2012-01-01

    The Office of Chief Technologist (OCT), NASA has identified the need for research and technology development in part from NASA's Strategic Goal 3.3 of the NASA Strategic Plan to develop and demonstrate the critical technologies that will make NASA's exploration, science, and discovery missions more affordable and more capable. Furthermore, the Game Changing Development Program (GCDP) is a primary avenue to achieve the Agency's 2011 strategic goal to "Create the innovative new space technologies for our exploration, science, and economic future." In addition, recently released "NASA space Technology Roadmaps and Priorities," by the National Research Council (NRC) of the National Academy of Sciences stresses the need for NASA to invest in the very near term in specific EDL technologies. The report points out the following challenges (Page 2-38 of the pre-publication copy released on February 1, 2012): Mass to Surface: Develop the ability to deliver more payload to the destination. NASA's future missions will require ever-greater mass delivery capability in order to place scientifically significant instrument packages on distant bodies of interest, to facilitate sample returns from bodies of interest, and to enable human exploration of planets such as Mars. As the maximum mass that can be delivered to an entry interface is fixed for a given launch system and trajectory design, the mass delivered to the surface will require reduction in spacecraft structural mass; more efficient, lighter thermal protection systems; more efficient lighter propulsion systems; and lighter, more efficient deceleration systems. Surface Access: Increase the ability to land at a variety of planetary locales and at a variety of times. Access to specific sites can be achieved via landing at a specific location (s) or transit from a single designated landing location, but it is currently infeasible to transit long distances and through extremely rugged terrain, requiring landing close to the

  2. Intraovarian markers of follicular and oocyte maturation.

    Science.gov (United States)

    Pellicer, A; Diamond, M P; DeCherney, A H; Naftolin, F

    1987-08-01

    The use of ovulation induction for multiple follicular growth in in vitro fertilization (IVF) has introduced the problem of follicular asynchrony. As a consequence of the asynchrony, the parameters most commonly used by IVF groups to assess follicular and oocyte quality within those follicles are not sufficiently sensitive or specific. Thus, each follicle must be considered separately, and specific markers of follicular and/or oocyte maturation must be sought from within the follicle. In this review we analyze previous reports of potential markers of follicular and oocyte maturation. In regards to the follicular fluid constituents, the level of estradiol in follicular fluid correlates with fertilization and pregnancy in stimulated cycles. Other steroids are only helpful when specific stimulation protocols are used. The level of some follicular proteins such as alpha-1-antitrypsin and fibrinogen also correlates with fertilization and pregnancy outcome. Cyclic AMP levels in follicular fluid are significantly reduced in follicles leading to conception. Regulators of oocyte maturation, such as the Oocyte Maturation Inhibitor (OMI) or the Meiosis Inducing Substance (MIS) have also been correlated with IVF outcome, but their exact structure remains still unknown. In addition, other sophisticated parameters, such as chemotactic activity of human leukocytes, or simple methods, such as the presence of intrafollicular echoes, have also been used as successful markers in predicting IVF outcome.

  3. Correlation Between Dental and Cervical Vertebral Maturation in Iranian Females

    OpenAIRE

    Valizadeh, Solmaz; Eil, Nakissa; Ehsani, Sara; Bakhshandeh, Hooman

    2012-01-01

    Background Considerable variations in the development stage among patients of the same chronological age have led to introduce the concept of the developmental age based on the maturation of different organs such as cervical vertebrae or teeth. Objectives The purpose of this study was to investigate the correlation between the stages of tooth calcification and the cervical vertebral maturation in Iranian females. Patients and Methods Four hundred females (age range, 8 to 14 years) participate...

  4. Integrating health education and physical activity programming for cardiovascular health promotion among female inmates: A proof of concept study.

    Science.gov (United States)

    Nair, Uma S; Jordan, Jeremy S; Funk, Daniel; Gavin, Kristin; Tibbetts, Erica; Collins, Bradley N

    2016-05-01

    Female inmate populations in the United States tend to be overweight, physically inactive, experience high stress, and have a history of nicotine and other drug dependence. Thus, they bear an elevated risk of cardiovascular (CV) disease than the general population. However, few evidence-based health interventions exist for this population. This study will test proof of concept, feasibility, and potential efficacy of a multiple health behavior change intervention that integrates CV-health promotion education delivered during a physical activity (PA) program (indoor cycling) tailored to this population. This study uses a quasi-experimental 2-group design with two measurement time-points: baseline and 8-week end of treatment. N=120 incarcerated women (18-59years of age) who are medically cleared for participation in PA will be enrolled. Indoor cycling instructors will be trained to deliver five health education topics over an 8-week period during twice-weekly cycling classes. Topics match the American Heart Association recommendations for CV health: (a) nutrition, (b) PA promotion, (c) weight management, (d) stress management, and (e) smoking cessation and relapse prevention. Modes of intervention include instructor advice, written materials and audio/video clips reviewed during class. CV-related and mental health measures will be assessed at both time-points. Results will guide a full scale efficacy study. Future research in this area has potential to impact the health of female inmates, a high-risk population. Moreover, this multiple health behavior change intervention model represents a community approach to health promotion that could generalize to other underserved populations who may benefit most from similar intervention efforts. Copyright © 2016 Elsevier Inc. All rights reserved.

  5. EMOTIONAL MATURITY OF PERSONALITY: THE PRACTICAL PROBLEM OF PSYCHOLOGICAL DIAGNOSIS

    OpenAIRE

    O. I. Afonina

    2013-01-01

    In the dif?cult conditions of the contemporary society which are far from being favorable to maintain one’s emotional and physical health the problem of development and achievement of emotional maturity as a factor of the well-being is getting more signi?cant. Based on the theoretical concepts of different scientists who de?ned the construct of emotional maturity three groups of psychological methods for assessing emotional maturity are analyzed. The ?rst group includes the methods that are u...

  6. Conceptos claves en un programa educativo Conceitos chave em um programa educativo Key Concepts in an Educational Program

    Directory of Open Access Journals (Sweden)

    MYRIAM PATRICIA PARDO TORRES

    2010-10-01

    are hereby presented on literature regarding assertive communication concepts, feelings and visions of nursing as a reciprocal and a simultaneous support for an educational program based on intervention with adolescents to promote responsible procreation. The present literature review took Ebsco-Host and Scielo as databases. Conclusion: Assertive communication is a learned social skill, which needs to be strengthened in as much as programs of sexual and reproductive health are concerned. Affection is a motivator for transmission and acquisition of knowledge in sexual and in reproductive education matters; the vision of reciprocity allows for interaction between the adolescent and the nurse and is a necessary component for mutual construction of self - care in this area, and the vision of simultaneity integrates the context as a key element in addressing the issue within a educational program.

  7. Key Concepts in an Educational Program Conceptos claves en un programa educativo Conceitos chave em um programa educativo

    Directory of Open Access Journals (Sweden)

    ARANGO MARTÍNEZ CATHERINE

    2010-10-01

    Full Text Available

    The results of the review are hereby presented on literature regarding assertive communication concepts, feelings and visions of nursing as a reciprocal and a simultaneous support for an educational program based on intervention with adolescents to promote responsible procreation. The present literature review took Ebsco-Host and Scielo as databases.

    Conclusion: Assertive communication is a learned social skill, which needs to be strengthened in as much as programs of sexual and reproductive health are concerned. Affection is a motivator for transmission and acquisition of knowledge in sexual and in reproductive education matters; the vision of reciprocity allows for interaction between the adolescent and the nurse and is a necessary component for mutual construction of self - care in this area, and the vision of simultaneity integrates the context as a key element in addressing the issue within a educational program.

    Se presentan los resultados de la revisión de literatura sobre los conceptos comunicación asertiva, afecto y las visiones de enfermería de reciprocidad y simultaneidad como sustento base de un programa educativo de intervención con adolescentes para promover la responsabilidad procreativa. La revisión bibliográfica sistemática tomó como bases de datos Ebsco-Host y Scielo.

    Conclusiones: la comunicación asertiva es una habilidad social aprendida, que es necesario fortalecer en los programas de salud sexual y reproductiva; el afecto es un elemento motivador para la transmisión y apropiación de conocimientos en educación sexual y reproductiva; la visión de reciprocidad orienta la interacción entre el (la adolescente y la (el enfermera (o componente necesario para una construcción mutua del autocuidado en este ámbito, y la visión de simultaneidad integra el contexto como elemento

  8. Methodology for Diagnostics of the Company Management and Technological Maturity

    Directory of Open Access Journals (Sweden)

    Olena Martynyuk

    2017-12-01

    Full Text Available Approaches to the measurement and assessment of the company technological maturity level and management maturity apart, formulated in scientific researches and practical recommendations, significantly differ according to their purpose, content and depth of the factors analysis. Studies of the company technological maturity and possibility for implementing business processes and certain IT technologies have become more advanced in some degree. The general idea of forming a model of diagnostics of the management and technological maturity is based on the determination of prevailing company system influence components. Management techniques are a nucleus of the model, and the innovation level of management techniques is an energy impulse inciting to development. Basing on the analysis performed, the author created a concept of levels of the company management and technological maturity considering the main parameters of the company management and technological maturity. A composite algorithm was proposed for determining the level of managerial technological maturity (LMTM, end exposition of a complex of management techniques to ensure the company dynamic progress based on determining a level of the management and technological maturity. The advantages and disadvantages are determined by the methodology. The performed approbation has confirmed the approach validity and its usefulness. The approbation shows the reliability and unambiguity of interpreting results. To use it for bigger enterprises and corporations, it is not even necessary to change identification parameters.

  9. Maturity Models in Supply Chain Sustainability: A Systematic Literature Review

    Directory of Open Access Journals (Sweden)

    Elisabete Correia

    2017-01-01

    Full Text Available A systematic literature review of supply chain maturity models with sustainability concerns is presented. The objective is to give insights into methodological issues related to maturity models, namely the research objectives; the research methods used to develop, validate and test them; the scope; and the main characteristics associated with their design. The literature review was performed based on journal articles and conference papers from 2000 to 2015 using the SCOPUS, Emerald Insight, EBSCO and Web of Science databases. Most of the analysed papers have as main objective the development of maturity models and their validation. The case study is the methodology that is most widely used by researchers to develop and validate maturity models. From the sustainability perspective, the scope of the analysed maturity models is the Triple Bottom Line (TBL and environmental dimension, focusing on a specific process (eco-design and new product development and without a broad SC perspective. The dominant characteristics associated with the design of the maturity models are the maturity grids and a continuous representation. In addition, results do not allow identifying a trend for a specific number of maturity levels. The comprehensive review, analysis, and synthesis of the maturity model literature represent an important contribution to the organization of this research area, making possible to clarify some confusion that exists about concepts, approaches and components of maturity models in sustainability. Various aspects associated with the maturity models (i.e., research objectives, research methods, scope and characteristics of the design of models are explored to contribute to the evolution and significance of this multidimensional area.

  10. Correlation between dental maturity and cervical vertebral maturity.

    Science.gov (United States)

    Chen, Jianwei; Hu, Haikun; Guo, Jing; Liu, Zeping; Liu, Renkai; Li, Fan; Zou, Shujuan

    2010-12-01

    The aim of this study was to investigate the association between dental and skeletal maturity. Digital panoramic radiographs and lateral skull cephalograms of 302 patients (134 boys and 168 girls, ranging from 8 to 16 years of age) were examined. Dental maturity was assessed by calcification stages of the mandibular canines, first and second premolars, and second molars, whereas skeletal maturity was estimated by the cervical vertebral maturation (CVM) stages. The Spearman rank-order correlation coefficient was used to measure the association between CVM stage and dental calcification stage of individual teeth. The mean chronologic age of girls was significantly lower than that of boys in each CVM stage. The Spearman rank-order correlation coefficients between dental maturity and cervical vertebral maturity ranged from 0.391 to 0.582 for girls and from 0.464 to 0.496 for boys (P cervical vertebral maturation stage. The development of the mandibular second molar in females and that of the mandibular canine in males had the strongest correlations with cervical vertebral maturity. Therefore, it is practical to consider the relationship between dental and skeletal maturity when planning orthodontic treatment. Copyright © 2010 Mosby, Inc. All rights reserved.

  11. Mature Cystic Renal Teratoma

    International Nuclear Information System (INIS)

    Yavuz, Alpaslan; Ceken, Kagan; Alimoglu, Emel; Akkaya, Bahar

    2014-01-01

    Teratomas are rare germline tumors that originate from one or more embryonic germ cell layers. Teratoma of the kidney is extremely rare, and less than 30 cases of primary intrarenal teratomas have been published to date. We report the main radiologic features of an unusual case of mature cystic teratoma arising from the left kidney in a two-year-old boy. A left-sided abdominal mass was detected on physical examination and B-Mod Ultrasound (US) examination revealed a heterogeneous mass with central cystic component. Computed tomography (CT) demonstrated a lobulated, heterogeneous, hypodense mass extending craniocaudally from the splenic hilum to the level of the left iliac fossa. Nephrectomy was performed and a large, fatty mass arising from the left kidney was excised. The final pathologic diagnosis was confirmed as cystic renal teratoma

  12. EMOTIONAL MATURITY OF PERSONALITY: THE PRACTICAL PROBLEM OF PSYCHOLOGICAL DIAGNOSIS

    Directory of Open Access Journals (Sweden)

    O. I. Afonina

    2013-03-01

    Full Text Available In the dif?cult conditions of the contemporary society which are far from being favorable to maintain one’s emotional and physical health the problem of development and achievement of emotional maturity as a factor of the well-being is getting more signi?cant. Based on the theoretical concepts of different scientists who de?ned the construct of emotional maturity three groups of psychological methods for assessing emotional maturity are analyzed. The ?rst group includes the methods that are used to assess emotional maturity explicitly and have a theoretical or empirical veri?cation. The second group includes the methods that are intended to assess emotional maturity as a separate scale complimented by other scales, related to evaluating other aspects of emotionality in  the  structure  of  the  personality.  The  third  group  includes  the  methods  in  which  emotional maturity is mentioned in the description of other psychic phenomena, or in the interpretation of certain factors (scales. Psychodiagnostic methods studying different parameters depending on the theoretical concepts of the authors about the structure and content of the emotional maturity of the personality make references to concepts of emotional development, consciousness, cognitive and volitional capacities of the personality and the coping strategies the individual prefer to use. The problem of developing valid and reliable psychodiagnostic methods of studying emotional maturity of the adult personality as a holistic phenomenon still awaits attention and retains its signi?cance.

  13. Developing maturity grids for assessing organisational capabilities

    DEFF Research Database (Denmark)

    Maier, Anja; Moultrie, James; Clarkson, P John

    2009-01-01

    Keyword: Maturity Model,Maturity Grid,Maturity Matrix,Organisational Capabilities,Benchmarking,New Product Development,Perfirmance Assessment......Keyword: Maturity Model,Maturity Grid,Maturity Matrix,Organisational Capabilities,Benchmarking,New Product Development,Perfirmance Assessment...

  14. Modeling non-maturing liabilities

    OpenAIRE

    von Feilitzen, Helena

    2011-01-01

    Non‐maturing liabilities, such as savings accounts, lack both predetermined maturity and reset dates due to the fact that the depositor is free to withdraw funds at any time and that the depository institution is free to change the rate. These attributes complicate the risk management of such products and no standardized solution exists. The problem is important however since non‐maturing liabilities typically make up a considerable part of the funding of a bank. In this report different mode...

  15. Comparison of changes in physical self-concept, global self-esteem, depression and anxiety following two different psychomotor therapy programs in nonpsychotic psychiatric inpatients.

    Science.gov (United States)

    Knapen, Jan; Van de Vliet, Peter; Van Coppenolle, Herman; David, Ans; Peuskens, Joseph; Pieters, Guido; Knapen, Koen

    2005-01-01

    The first objective of this study was to compare the changes in physical self-concept, global self-esteem, depression and anxiety after participation in one of two 16-week psychomotor therapy programs for nonpsychotic psychiatric inpatients. The second objective was to study the relationship between changes in these variables. One hundred and ninety-nine inpatients were randomly assigned to either a personalized psychomotor fitness program, consisting of aerobic exercise and weight training, or a general program of psychomotor therapy, consisting of different forms of physical exercises and relaxation training. Physical self-concept was evaluated using the Dutch version of the Physical Self-Perception Profile at baseline, after 8 weeks, and after completion of the 16-week interventions. At the same time points, additional variables of global self-esteem, depression and anxiety were assessed by means of the Rosenberg Self-Esteem Inventory, the Beck Depression Inventory and the Trait Anxiety Inventory, respectively. After 16 weeks, both groups showed significant improvements in all outcome measures (p values ranged from 0.01 to self-esteem and decreased depression and anxiety levels (p self-esteem, depression and anxiety supports the potential role of the physical self-concept in the recovery process of depressed and anxious psychiatric inpatients. Copyright (c) 2005 S. Karger AG, Basel.

  16. A Program of Research and Education to Advance the Design, Synthesis, and Optimization of Aero-Space System Concepts

    Science.gov (United States)

    Sandusky, Robert

    2002-01-01

    Since its inception in December 1999, the program has provided support for a total of 11 Graduate Research Scholar Assistants, of these, 6 have completed their MS degree program. The program has generated 3 MS theses and a total of 4 publications/presentations.

  17. Whose Maturity is it Anyway?

    DEFF Research Database (Denmark)

    Lasrado, Lester Allan; Vatrapu, Ravi; Mukkamala, Raghava Rao

    2017-01-01

    This paper presents results from an ongoing empirical study that seeks to understand the influence of different quantitative methods on the design and assessment of maturity models. Although there have been many academic publications on maturity models, there exists a significant lack of understa...

  18. The maturing of microbial ecology.

    Science.gov (United States)

    Schmidt, Thomas M

    2006-09-01

    A.J. Kluyver and C.B. van Niel introduced many scientists to the exceptional metabolic capacity of microbes and their remarkable ability to adapt to changing environments in The Microbe's Contribution to Biology. Beyond providing an overview of the physiology and adaptability of microbes, the book outlined many of the basic principles for the emerging discipline of microbial ecology. While the study of pure cultures was highlighted, provided a unifying framework for understanding the vast metabolic potential of microbes and their roles in the global cycling of elements, extrapolation from pure cultures to natural environments has often been overshadowed by microbiologists inability to culture many of the microbes seen in natural environments. A combination of genomic approaches is now providing a culture-independent view of the microbial world, revealing a more diverse and dynamic community of microbes than originally anticipated. As methods for determining the diversity of microbial communities become increasingly accessible, a major challenge to microbial ecologists is to link the structure of natural microbial communities with their functions. This article presents several examples from studies of aquatic and terrestrial microbial communities in which culture and culture-independent methods are providing an enhanced appreciation for the microbe's contribution to the evolution and maintenance of life on Earth, and offers some thoughts about the graduate-level educational programs needed to enhance the maturing field of microbial ecology.

  19. Profiling first-year students in STEM programs based on autonomous motivation and academic self-concept and relationship with academic achievement.

    Science.gov (United States)

    Van Soom, Carolien; Donche, Vincent

    2014-01-01

    The low success rate of first-year college students in Science, Technology, Engineering, and Mathematics (STEM) programs has spurred many academic achievement studies in which explanatory factors are studied. In this study, we investigated from a person-oriented perspective whether different motivational and academic self-concept profiles could be discerned between male and female first-year college students in STEM and whether differences in early academic achievement were associated with these student groups. Data on autonomous motivation, academic self-concept, and early academic achievement of 1,400 first-year STEM college students were collected. Cluster analyses were used to distinguish motivational profiles based on the relative levels of autonomous motivation and academic self-concept for male and female students. Differences in early academic achievement of the various profiles were studied by means of ANCOVA. Four different motivational profiles were discerned based on the dimensions of autonomous motivation (A) and academic self-concept (S): students scoring high and respectively low on both dimensions (HA-HS or LA-LS), and students scoring high on one dimension and low on the other (HA-LS or LA-HS). Also gender differences were found in this study: male students with high levels of academic self-concept and autonomous motivation had higher academic achievement compared to male students with low levels on both motivational dimensions. For female students, motivational profiles were not associated with academic achievement. The findings partially confirm the internal and external validity of the motivational theories underpinning this study and extend the present insights on identifying subgroup(s) of at risk students in contemporary STEM programs at university level.

  20. Profiling First-Year Students in STEM Programs Based on Autonomous Motivation and Academic Self-Concept and Relationship with Academic Achievement

    Science.gov (United States)

    Van Soom, Carolien; Donche, Vincent

    2014-01-01

    The low success rate of first-year college students in Science, Technology, Engineering, and Mathematics (STEM) programs has spurred many academic achievement studies in which explanatory factors are studied. In this study, we investigated from a person-oriented perspective whether different motivational and academic self-concept profiles could be discerned between male and female first-year college students in STEM and whether differences in early academic achievement were associated with these student groups. Data on autonomous motivation, academic self-concept, and early academic achievement of 1,400 first-year STEM college students were collected. Cluster analyses were used to distinguish motivational profiles based on the relative levels of autonomous motivation and academic self-concept for male and female students. Differences in early academic achievement of the various profiles were studied by means of ANCOVA. Four different motivational profiles were discerned based on the dimensions of autonomous motivation (A) and academic self-concept (S): students scoring high and respectively low on both dimensions (HA-HS or LA-LS), and students scoring high on one dimension and low on the other (HA-LS or LA-HS). Also gender differences were found in this study: male students with high levels of academic self-concept and autonomous motivation had higher academic achievement compared to male students with low levels on both motivational dimensions. For female students, motivational profiles were not associated with academic achievement. The findings partially confirm the internal and external validity of the motivational theories underpinning this study and extend the present insights on identifying subgroup(s) of at risk students in contemporary STEM programs at university level. PMID:25390942

  1. United States Program for Technical assistance to IAEA Standards. Concept Paper: Knowledge Acquisition, Skills training for enhanced IAEA safeguards inspections

    Energy Technology Data Exchange (ETDEWEB)

    Morris, F.A.; Toquam, J.L.

    1993-11-01

    This concept paper explores the potential contribution of ``Knowledge Acquisition Skills`` in enhancing the effectiveness of international safeguards inspections by the International Atomic energy Agency (IAEA, or Agency) and identifies types of training that could be provided to develop or improve such skills. For purposes of this concept paper, Knowledge Acquisition Skills are defined broadly to include all appropriate techniques that IAEA safeguards inspectors can use to acquire and analyze information relevant to the performance of successful safeguards inspections. These techniques include a range of cognitive, analytic, judgmental, interpersonal, and communications skills that have the potential to help IAEA safeguards inspectors function more effectively.

  2. Aviation Safety Program: Weather Accident Prevention (WxAP) Development of WxAP System Architecture And Concepts of Operation

    Science.gov (United States)

    Grantier, David

    2003-01-01

    This paper presents viewgraphs on the development of the Weather Accident Prevention (WxAP) System architecture and Concept of Operation (CONOPS) activities. The topics include: 1) Background Information on System Architecture/CONOPS Activity; 2) Activity Work in Progress; and 3) Anticipated By-Products.

  3. Evaluation of a training program for persons with SCI paraplegia using the Parastep 1 ambulation system: part 4. Effect on physical self-concept and depression.

    Science.gov (United States)

    Guest, R S; Klose, K J; Needham-Shropshire, B M; Jacobs, P L

    1997-08-01

    To determine whether persons with spinal cord injury (SCI) paraplegia who participated in an electrical stimulation walking program experienced changes in measures of physical self-concept and depression. Before-after trial. Human SCI applied research laboratory. Volunteer sample of 12 men and 3 women with SCI paraplegia, mean age 28.75 +/- 6.6yrs and mean duration of injury 3.8 +/- 3.2yrs. Thirty-two FNS ambulation training sessions using a commercially available system (Parastep 1). The hybrid system consists of a microprocessor-controlled stimulator and a modified walking frame with finger-operated switches that permit the user to control the stimulation parameters and activate the stepping. The Tennessee Self-Concept Scale (TSCS) and the Beck Depression Inventory (BDI) were administered before and after training. Only the Physical Self subscale of the TSCS was analyzed. After training, individual interviews were performed to assess participants' subjective reactions to the training program. A repeated measures analysis of variance indicated that desired directional and statistically significant changes occurred on the Physical Self subscale of the TSCS (F(1,14) = 8.54, p self-concept scores and decreases in depression scores.

  4. Maturation of the human fetal startle response: Evidence for sex-specific maturation of the human fetus1

    Science.gov (United States)

    Buss, Claudia; Davis, Elysia Poggi; Class, Quetzal A.; Gierczak, Matt; Pattillo, Carol; Glynn, Laura M.; Sandman, Curt A.

    2009-01-01

    Despite the evidence for early fetal experience exerting programming influences on later neurological development and health risk, very few prospective studies of human fetal behavior have been reported. In a prospective longitudinal study, fetal nervous system maturation was serially assessed by monitoring fetal heart rate (FHR) responses to vibroacoustic stimulation (VAS) in 191 maternal/fetal dyads. Responses were not detected at 26 weeks gestational age (GA). Sex-specific, age-characteristic changes in the FHR response to VAS were observed by 31 weeks’ GA. Males showed larger responses and continued to exhibit maturational changes until 37 weeks’ GA, females however, presented with a mature FHR startle response by 31 weeks’ GA. The results indicate that there are different rates of maturation in the male and female fetus that may have implications for sex-specific programming influences. PMID:19726143

  5. Maturation of the human fetal startle response: evidence for sex-specific maturation of the human fetus.

    Science.gov (United States)

    Buss, Claudia; Davis, Elysia Poggi; Class, Quetzal A; Gierczak, Matt; Pattillo, Carol; Glynn, Laura M; Sandman, Curt A

    2009-10-01

    Despite the evidence for early fetal experience exerting programming influences on later neurological development and health risk, very few prospective studies of human fetal behavior have been reported. In a prospective longitudinal study, fetal nervous system maturation was serially assessed by monitoring fetal heart rate (FHR) responses to vibroacoustic stimulation (VAS) in 191 maternal/fetal dyads. Responses were not detected at 26 weeks gestational age (GA). Sex-specific, age-characteristic changes in the FHR response to VAS were observed by 31 weeks' GA. Males showed larger responses and continued to exhibit maturational changes until 37 weeks' GA, females however, presented with a mature FHR startle response by 31 weeks' GA. The results indicate that there are different rates of maturation in the male and female fetuses that may have implications for sex-specific programming influences.

  6. Gas Reactor International Cooperative Program. Interim report. Safety and licensing evaluaion of German Pebble Bed Reactor concepts

    International Nuclear Information System (INIS)

    1978-09-01

    The Pebble Bed Gas Cooled Reactor, as developed in the Federal Republic of Germany, was reviewed from a United States Safety and Licensing perspective. The primary concepts considered were the steam cycle electric generating pebble bed (HTR-K) and the process heat pebble bed (PNP), although generic consideration of the direct cycle gas turbine pebble bed (HHT) was included. The study examines potential U.S. licensing issues and offers some suggestions as to required development areas

  7. "Thinking ethics": a novel, pilot, proof-of-concept program of integrating ethics into the Physiology curriculum in South India.

    Science.gov (United States)

    D, Savitha; Vaz, Manjulika; Vaz, Mario

    2017-06-01

    Integrating medical ethics into the physiology teaching-learning program has been largely unexplored in India. The objective of this exercise was to introduce an interactive and integrated ethics program into the Physiology course of first-year medical students and to evaluate their perceptions. Sixty medical students (30 men, 30 women) underwent 11 sessions over a 7-mo period. Two of the Physiology faculty conducted these sessions (20-30 min each) during the routine physiology (theory/practicals) classes that were of shorter duration and could, therefore, accommodate the discussion of related ethical issues. This exercise was in addition to the separate ethics classes conducted by the Medical Ethics department. The sessions were open ended, student centered, and designed to stimulate critical thinking. The students' perceptions were obtained through a semistructured questionnaire and focused group discussions. The students found the program unique, thought provoking, fully integrated, and relevant. It seldom interfered with the physiology teaching. They felt that the program sensitized them about ethical issues and prepared them for their clinical years, to be "ethical doctors." Neutral observers who evaluated each session felt that the integrated program was relevant to the preclinical year and that the program was appropriate in its content, delivery, and student involvement. An ethics course taught in integration with Physiology curriculum was found to be beneficial, feasible, and compatible with Physiology by students as well as neutral observers. Copyright © 2017 the American Physiological Society.

  8. Slab replacement maturity guidelines : [summary].

    Science.gov (United States)

    2014-04-01

    Concrete sets in hours at moderate temperatures, : but the bonds that make concrete strong continue : to mature over days to years. However, for : replacement concrete slabs on highways, it is : crucial that concrete develop enough strength : within ...

  9. SOUL System Maturation, Phase I

    Data.gov (United States)

    National Aeronautics and Space Administration — Busek Co. Inc. proposes to advance the maturity of an innovative Spacecraft on Umbilical Line (SOUL) System suitable for a wide variety of applications of interest...

  10. SOUL System Maturation, Phase II

    Data.gov (United States)

    National Aeronautics and Space Administration — Busek Co. Inc. proposes to advance the maturity of an innovative Spacecraft on Umbilical Line (SOUL) System suitable for a wide variety of applications of interest...

  11. Naturally Engineered Maturation of Cardiomyocytes

    Directory of Open Access Journals (Sweden)

    Gaetano J. Scuderi

    2017-05-01

    Full Text Available Ischemic heart disease remains one of the most prominent causes of mortalities worldwide with heart transplantation being the gold-standard treatment option. However, due to the major limitations associated with heart transplants, such as an inadequate supply and heart rejection, there remains a significant clinical need for a viable cardiac regenerative therapy to restore native myocardial function. Over the course of the previous several decades, researchers have made prominent advances in the field of cardiac regeneration with the creation of in vitro human pluripotent stem cell-derived cardiomyocyte tissue engineered constructs. However, these engineered constructs exhibit a functionally immature, disorganized, fetal-like phenotype that is not equivalent physiologically to native adult cardiac tissue. Due to this major limitation, many recent studies have investigated approaches to improve pluripotent stem cell-derived cardiomyocyte maturation to close this large functionality gap between engineered and native cardiac tissue. This review integrates the natural developmental mechanisms of cardiomyocyte structural and functional maturation. The variety of ways researchers have attempted to improve cardiomyocyte maturation in vitro by mimicking natural development, known as natural engineering, is readily discussed. The main focus of this review involves the synergistic role of electrical and mechanical stimulation, extracellular matrix interactions, and non-cardiomyocyte interactions in facilitating cardiomyocyte maturation. Overall, even with these current natural engineering approaches, pluripotent stem cell-derived cardiomyocytes within three-dimensional engineered heart tissue still remain mostly within the early to late fetal stages of cardiomyocyte maturity. Therefore, although the end goal is to achieve adult phenotypic maturity, more emphasis must be placed on elucidating how the in vivo fetal microenvironment drives cardiomyocyte

  12. Maturation of sugar maple seed

    Science.gov (United States)

    Clayton M., Jr. Carl; Albert G., Jr. Snow; Albert G. Snow

    1971-01-01

    The seeds of a sugar maple tree (Acer saccharum Marsh.) do not mature at the same time every year. And different trees mature their seeds at different times. So time of year is not a reliable measure of when seeds are ripe. Better criteria are needed. In recent studies we have found that moisture content and color are the best criteria for judging when sugar maple...

  13. Pharmaceutical Options for Triggering of Final Oocyte Maturation in ART

    Directory of Open Access Journals (Sweden)

    Juan Carlos Castillo

    2014-01-01

    Full Text Available Since the pioneering days of in vitro fertilization, hCG has been the gold standard to induce final follicular maturation. We herein reviewed different pharmaceutical options for triggering of final oocyte maturation in ART. The new upcoming agent seems to be GnRHa with its potential advantages over hCG trigger. GnRHa triggering elicits a surge of gonadotropins resembling the natural midcycle surge of gonadotropins, without the prolonged action of hCG, resulting in the retrieval of more mature oocytes and a significant reduction in or elimination of OHSS as compared to hCG triggering. The induction of final follicular maturation using GnRHa represents a paradigm shift in the ovulation triggering concept in ART and, thus, a way to develop a safer IVF procedure. Kisspeptins are key central regulators of the neuroendocrine mechanisms of human reproduction, who have been shown to effectively elicit an LH surge and to induce final oocyte maturation in IVF cycles. This new trigger concept may, therefore, offer a completely new, “natural” pharmacological option for ovulation induction. Whether kisspeptins will be the future agent to trigger ovulation remains to be further explored.

  14. The AGU Data Management Maturity Model Initiative

    Science.gov (United States)

    Bates, J. J.

    2015-12-01

    In September 2014, the AGU Board of Directors approved two initiatives to help the Earth and space sciences community address the growing challenges accompanying the increasing size and complexity of data. These initiatives are: 1) Data Science Credentialing: development of a continuing education and professional certification program to help scientists in their careers and to meet growing responsibilities and requirements around data science; and 2) Data Management Maturity (DMM) Model: development and implementation of a data management maturity model to assess process maturity against best practices, and to identify opportunities in organizational data management processes. Each of these has been organized within AGU as an Editorial Board and both Boards have held kick off meetings. The DMM model Editorial Board will recommend strategies for adapting and deploying a DMM model to the Earth and space sciences create guidance documents to assist in its implementation, and provide input on a pilot appraisal process. This presentation will provide an overview of progress to date in the DMM model Editorial Board and plans for work to be done over the upcoming year.

  15. A New Concept for a Business Ethics Program and the Development of a Monitoring Method for the Engineering Ethics Environment of a Corporation

    Science.gov (United States)

    Okita, Yuji; Hayase, Kenichi; Oba, Kyoko; Fudano, Jun

    For most modern corporations, engineering is an essential element. While the public increasingly demands social responsibility in business activities, the importance of the interweaving relationship between business ethics and engineering ethics has been recognized. In this paper, firstly the change in the business environment is overviewed. Then, a new concept for designing and implementing a business ethics program, named the EAB (Ethics Across the Business) approach, is proposed. The EAB approach is highly adaptable for engineering-oriented corporations in their business ethics program activities because it derives from a process approach which has been much used by many companies to perform such activities as quality assurance and environment management. Finally, a newly developed method to monitor employee consciousness in terms of engineering ethics is introduced together with trial results.

  16. Conceptions and last works of Canberra-Packard firm in the field of radiation protection and environment and work's experience in the Chernobyl programs

    International Nuclear Information System (INIS)

    Toritsin, O.S.; Kampagnuolo, B.

    1993-01-01

    The history of spectrometric system produced by firm is given. New generation of spectrometric equipment includes new multi-using program software on base 386-486 IBM and new generation of programming and control module. System for measuring of radioactivity level of radioactive wastes is based on the requirement of transmission ability and on levels of minimum detected activity. Firm proposes two main types of such system. Because of last time every where in the world are registered leaks of radioactive materials from its produced plants the firm generated two types systems for solving of this problem: both the stationary and the portable. There are arcs for control of personnel and transport based on registration gamma-radiation, and also system for defining neutron spontaneous fission. For solving problem on vast territories it is necessary conduct spectrometric and radiometric measuring with mobile laboratories. For this aims firm proposed number of conceptions, one of them includes sea container's complete equipment of apparatus

  17. Development and Study the Usage of Blended Learning Environment Model Using Engineering Design Concept Learning Activities to Computer Programming Courses for Undergraduate Students of Rajabhat Universities

    Directory of Open Access Journals (Sweden)

    Kasame Tritrakan

    2017-06-01

    Full Text Available The objectives of this research were to study and Synthesise the components, to develop, and to study the usage of blended learning environment model using engineering design concept learning activities to computer programming courses for undergraduate students of Rajabhat universities. The research methodology was divided into 3 phases. Phase I: surveying presents, needs and problems in teaching computer programming of 52 lecturers by using in-depth interview from 5 experienced lecturers. The model’s elements were evaluated by 5 experts. The tools were questionnaire, interview form, and model’s elements assessment form. Phase II: developing the model of blended learning environment and learning activities based on engineering design processes and confirming model by 8 experts. The tools were the draft of learning environment, courseware, and assessment forms. Phase III evaluating the effects of using the implemented environment. The samples were students which formed into 2 groups, 25 people in the experiment group and 27 people in the control group by cluster random sampling. The tools were learning environment, courseware, and assessment tools. The statistics used in this research were means, standard deviation, t-test dependent, and one-way MANOVA. The results found that: 1 Lecturers quite agreed with the physical, mental, social, and information learning environment, learning processes, and assessments. There were all needs in high level. However there were physical environment problems in high level yet quite low in other aspects. 2 The developed learning environment had 4 components which were a 4 types of environments b the inputs included blended learning environment, learning motivation factors, and computer programming content c the processes were analysis of state objectives, design learning environment and activities, developing learning environment and testing materials, implement, ation evaluation and evaluate, 4 the outputs

  18. How to manage sustainable supply chain? The issue of maturity

    Directory of Open Access Journals (Sweden)

    Agata Rudnicka

    2016-12-01

    Full Text Available Background: The issue of managing sustainability in supply chain seems to be more and more complex. There are many aspects that need to be taken into consideration when planning, implementing and monitoring environmental and social conditions of supply chains. Despite many works, already published, on the concept of sustainable development (SD is seems that the issue of assessment and especially the issue of maturity in the light of the SD concept is still not developed enough. Methods: The general aim of the paper is the analysis of the maturity issue in the context of sustainability. The main objective is to conceptualize the idea of maturity in sustainable supply chain. Beside the literature research the own proposition of theoretical model was described. Results: The article describes the issue of maturity as an element of managing sustainable development in the supply chain. The author presented a theoretical model of the maturity. Moreover the author gave some recommendations how to manage the sustainability issues in supply chain in more mature approach and introduced some useful tools among which are: certification, code of conduct and code of ethics, audits, projects etc. Conclusions: The issue of maturity seems to be very useful for proper understanding the idea of sustainable development in supply chain. The developed model can be used as self-assessment method to check at which level of implementation the idea of SD is analyzed in supply chain. Furthermore, the next phase of the planned research in form of practical verification of the model was advised as well as a research of identification of new factors and tools in analyzed area.

  19. Mall shopping preferences and patronage of mature shoppers

    Directory of Open Access Journals (Sweden)

    Gabriel G. Rousseau

    2014-04-01

    Research purpose: The purpose of this study was to investigate the buying behaviour of mature consumers (older than 55 in Port Elizabeth shopping malls. Motivation for the study: The perception of mature shoppers as old people with limited financial resources is untrue. This study investigates the behaviours of mature shoppers. Research design, approach and method: A model guided the investigation. The authors facilitated four focus groups to gain insight into mature consumers’ buying behaviours. A field survey followed with a sample of mall shoppers (n = 680. The authors performed content analysis of the focus group material and used SPSS and AMOS programs to analyse the data quantitatively. Main findings: Focus group interviews revealed specific buying behaviours of mature shoppers. The survey showed significant relationships between various determinants that influence respondents’ buying behaviours with adequate model fit indices. These results confirmed the convergent and discriminant validity of the model that comprises mall shopping anticipation, experience and patronage. Practical/managerial implications: Mature shoppers’ expectations exceeded their experiences, suggesting dissatisfaction with some aspects of their experiences. Retailers and shopping mall managers need to redesign malls if they wish to cater for the segment of ageing shoppers and their spending power. Contribution/value-add: The study contributes to the research available in South Africa on service at shopping malls that cater for mature consumers.

  20. Developing the Value Management Maturity Model (VM3©

    Directory of Open Access Journals (Sweden)

    Saipol Bari Abd Karim

    2013-06-01

    Full Text Available Value management (VM practices have been expanded and became a well-received technique globally. Organisations are now progressing towards a better implementation of VM and should be assessing their strengths and weaknesses in order to move forward competitively. There is a need to benchmark the existing VM practices to reflect their maturing levels which is currently not available. This paper outlines the concept of Value Management Maturity Model (VM3' as a structured plan of maturity and performance growth for businesses. It proposes five levels of maturity and each level has its own criteria or attributes to be achieved before progressing to a higher level. The framework for VM3' has been developed based on the review of literatures related to VM and maturity models (MM. Data is collected through questionnaire surveys to organisations that have implemented VM methodology. Additionally, semi-structured interviews were conducted to select individuals involved in implementing VM. The questions were developed to achieve the research objectives; investigating the current implementation of VM and, exploring the organisation's MM knowledge and practices. However, this research was limited to VM implementation in the Malaysian government's projects and programmes. VM3' introduces a new paradigm in VM as it provides a rating method for capabilities or performance. It is advocated that this VM3' framework is still being refined in the advance stage in order to provide a comprehensive and well accepted method to provide ratings for organisations' maturity.

  1. Understanding Acid-Base Concepts: Evaluating the Efficacy of a Senior High School Student-Centred Instructional Program in Indonesia

    Science.gov (United States)

    Rahayu, Sri; Chandrasegaran, A. L.; Treagust, David F.; Kita, Masakazu; Ibnu, Suhadi

    2011-01-01

    This study was a mixed quantitative-qualitative research to evaluate the efficacy of a designed student-centred instructional (DSCI) program for teaching about acids and bases. The teaching innovation was designed based on constructivist, hands-on inquiry and context-based approaches and implemented in seven 45-min lessons with a class of 36 grade…

  2. Application of Resource Portfolio Concept in Nuclear Regulatory Infrastructure Support

    International Nuclear Information System (INIS)

    Lee, Y. E.; Ha, J. T.; Chang, H. S.; Kam, S. C.; Ryu, Y. H.

    2010-01-01

    As the new entrants in the global nuclear construction market are increasing and the establishment of an effective and sustainable regulatory infrastructure becomes more important, they have requested international assistance from the international nuclear communities with mature nuclear regulatory programmes. It needs to optimize the use of limited resources from regulatory organization providing support to regulatory infrastructure of new comers. This paper suggests the resource portfolio concept like a GE/Mckinsey Matrix used in business management and tries to apply it to the current needs considered in the regulatory support program in Korea as the case study

  3. The Need for Technology Maturity of Any Advanced Capability to Achieve Better Life Cycle Cost (LCC)

    Science.gov (United States)

    Robinson, John W.; Levack, Daniel J. H.; Rhodes, Russel E.; Chen, Timothy T.

    2009-01-01

    Programs such as space transportation systems are developed and deployed only rarely, and they have long development schedules and large development and life cycle costs (LCC). They have not historically had their LCC predicted well and have only had an effort to control the DDT&E phase of the programs. One of the factors driving the predictability, and thus control, of the LCC of a program is the maturity of the technologies incorporated in the program. If the technologies incorporated are less mature (as measured by their Technology Readiness Level - TRL), then the LCC not only increases but the degree of increase is difficult to predict. Consequently, new programs avoid incorporating technologies unless they are quite mature, generally TRL greater than or equal to 7 (system prototype demonstrated in a space environment) to allow better predictability of the DDT&E phase costs unless there is no alternative. On the other hand, technology development programs rarely develop technologies beyond TRL 6 (system/subsystem model or prototype demonstrated in a relevant environment). Currently the lack of development funds beyond TRL 6 and the major funding required for full scale development leave little or no funding available to prototype TRL 6 concepts so that hardware would be in the ready mode for safe, reliable and cost effective incorporation. The net effect is that each new program either incorporates little new technology or has longer development schedules and costs, and higher LCC, than planned. This paper presents methods to ensure that advanced technologies are incorporated into future programs while providing a greater accuracy of predicting their LCC. One method is having a dedicated organization to develop X-series vehicles or separate prototypes carried on other vehicles. The question of whether such an organization should be independent of NASA and/or have an independent funding source is discussed. Other methods are also discussed. How to make the

  4. Transportation System Concept of Operations

    Energy Technology Data Exchange (ETDEWEB)

    N. Slater-Thompson

    2006-08-16

    level descriptions. of subsystems and components, and the Transportation System Requirements Document. Other program and system documents, plans, instructions, and detailed designs will be consistent with and informed by the Transportation System Concept of Operations. The Transportation System Concept of Operations is a living document, enduring throughout the OCRWM systems engineering lifecycle. It will undergo formal approval and controlled revisions as appropriate while the Transportation System matures. Revisions will take into account new policy decisions, new information available through system modeling, engineering investigations, technical analyses and tests, and the introduction of new technologies that can demonstrably improve system performance.

  5. Correlation Between Dental and Cervical Vertebral Maturation in Iranian Females

    Science.gov (United States)

    Valizadeh, Solmaz; Eil, Nakissa; Ehsani, Sara; Bakhshandeh, Hooman

    2012-01-01

    Background Considerable variations in the development stage among patients of the same chronological age have led to introduce the concept of the developmental age based on the maturation of different organs such as cervical vertebrae or teeth. Objectives The purpose of this study was to investigate the correlation between the stages of tooth calcification and the cervical vertebral maturation in Iranian females. Patients and Methods Four hundred females (age range, 8 to 14 years) participated in the study. To determine the dental maturational stage, calcification of the mandibular teeth except for third molars were rated according to the method suggested by Demirjian et al. To evaluate the stage of skeletal maturation, cervical vertebral morphologic changes were assessed on lateral cephalometric radiographs according to the method explained by Baccetti et al. Correlations between bone maturation and teeth calcification were showed by Spearman's correlation and Kendall’s tau-b coefficients. The relevant associations were investigated by ordinal logistic regression models. Results Correlations between the two stages were observed in the first and second premolars, canine and central incisors. All these correlations were significant. The association between cervical vertebral maturation and tooth calcification was greatest in the lateral incisor (odds ratio (OR) = 11, 95% confidence interval (CI): 6.6-18.3). However, considering the 95% CI for OR, no significant difference was detected among the second molar, first molar and lateral incisor. Conclusion The relationship between calcification of teeth and maturation of cervical bones was significant. Bone maturation can be predicted by using teeth calcification stages, especially in the second molar, first molar and lateral incisor. PMID:23599706

  6. Correlation between dental and cervical vertebral maturation in Iranian females.

    Science.gov (United States)

    Valizadeh, Solmaz; Eil, Nakissa; Ehsani, Sara; Bakhshandeh, Hooman

    2012-12-01

    Considerable variations in the development stage among patients of the same chronological age have led to introduce the concept of the developmental age based on the maturation of different organs such as cervical vertebrae or teeth. The purpose of this study was to investigate the correlation between the stages of tooth calcification and the cervical vertebral maturation in Iranian females. Four hundred females (age range, 8 to 14 years) participated in the study. To determine the dental maturational stage, calcification of the mandibular teeth except for third molars were rated according to the method suggested by Demirjian et al. To evaluate the stage of skeletal maturation, cervical vertebral morphologic changes were assessed on lateral cephalometric radiographs according to the method explained by Baccetti et al. Correlations between bone maturation and teeth calcification were showed by Spearman's correlation and Kendall's tau-b coefficients. The relevant associations were investigated by ordinal logistic regression models. Correlations between the two stages were observed in the first and second premolars, canine and central incisors. All these correlations were significant. The association between cervical vertebral maturation and tooth calcification was greatest in the lateral incisor (odds ratio (OR) = 11, 95% confidence interval (CI): 6.6-18.3). However, considering the 95% CI for OR, no significant difference was detected among the second molar, first molar and lateral incisor. The relationship between calcification of teeth and maturation of cervical bones was significant. Bone maturation can be predicted by using teeth calcification stages, especially in the second molar, first molar and lateral incisor.

  7. Power Conditioning And Distribution Units For 50V Platforms A Flexible And Modular Concept Allowing To Deal With Time Constraining Programs

    Science.gov (United States)

    Lempereur, V.; Liegeois, B.; Deplus, N.

    2011-10-01

    In the frame of its Power Conditioning and Distribution Unit (PCDU) Medium power product family, Thales Alenia space ETCA is currently developing Power Conditioning Unit (PCU) and PCDU products for 50V platforms applications. These developments are performed in very schedule constraining programs. This challenge can be met thanks to the modular PCDU concept allowing to share a common heritage at mechanical & thermal points of view as well as at electrical functions level. First Medium power PCDU application has been developed for Herschel-Planck PCDU and re-used in several other missions (e.g. GlobalStar2 PCDU for which we are producing more than 26 units). Based on this heritage, a development plan based on Electrical Model (EM) (avoiding Electrical Qualification Model - EQM) can be proposed when the mechanical qualification of the concept covers the environment required in new projects. This first heritage level allows reducing development schedule and activities. In addition, development is also optimized thanks to the re-use of functions designed and qualified in Herschel- PlanckPCDU. This coversinternal TM/TC management inside PCDU based on a centralized scheduler and an internal high speed serial bus. Finally, thanks to common architecture of several 50V platforms based on full regulated bus, S3R (Sequential Shunt Switch Regulator) concept and one (or two) Li- Ion battery(ies), a common PCU/PCDU architecture has allowed the development of modules or functions that are used in several applications. These achievements are discussed with particular emphasis on PCDU architecture trade-offs allowing flexibility of proposed technical solutions (w.r.t. mono/bi-battery configurations, SA inner capacitance value, output power needs...). Pro's and con's of sharing concepts and designs between several applications on 50V platforms are also be discussed.

  8. The use of check valve performance data to support new concepts (probabilistic risk assessment, condition monitoring) for check valve program

    Energy Technology Data Exchange (ETDEWEB)

    Hart, K.A.; Gower, D.

    1996-12-01

    The concept of developing an integrated check valve database based on the Nuclear Power Reliability Data System (NPRDS) data was presented at the last Symposium. The Nuclear Industry Check Valve Group (NIC), working in cooperation with the Oak Ridge National Laboratory (ORNL), has completed an operational database of check valve performance from 1984 to the present. NIC has committed to the nuclear industry to periodically update the data and maintain this information accessible. As the new concepts of probabilistic risk analysis and condition monitoring are integrated into the American Society of Mechanical Engineers (ASME) Code, a critical element will be performance data. From check valve performance data, feasible failure modes and rates can be established. When a failure rate or frequency of failures can be established based on a significant enough population (sampling), a more solid foundation for focusing resources and determining appropriate frequencies and testing can be determined. The presentation will give the updated status of the NIC Check Valve Performance Database covering (1) methodology used to combine the original ORNL data; (2) process/controls established for continuing update and refinement of the data; (3) discussion of how this data is being utilized by (a) OM-22 for condition monitoring, and (b) risk-based inservice testing work of Westinghouse Owners` Group; and (4) results/trends of data evaluations. At the 1994 Symposium, ORNL provided an update as of 1991 to their original work of 1984 -1990 which they had performed to characterize check valve degradations and failures in the nuclear industry. These characterizations will be updated to 1995 and additional reviews provided to give insight into the current condition and trends of check valve performance.

  9. The use of check valve performance data to support new concepts (probabilistic risk assessment, condition monitoring) for check valve program

    International Nuclear Information System (INIS)

    Hart, K.A.; Gower, D.

    1996-01-01

    The concept of developing an integrated check valve database based on the Nuclear Power Reliability Data System (NPRDS) data was presented at the last Symposium. The Nuclear Industry Check Valve Group (NIC), working in cooperation with the Oak Ridge National Laboratory (ORNL), has completed an operational database of check valve performance from 1984 to the present. NIC has committed to the nuclear industry to periodically update the data and maintain this information accessible. As the new concepts of probabilistic risk analysis and condition monitoring are integrated into the American Society of Mechanical Engineers (ASME) Code, a critical element will be performance data. From check valve performance data, feasible failure modes and rates can be established. When a failure rate or frequency of failures can be established based on a significant enough population (sampling), a more solid foundation for focusing resources and determining appropriate frequencies and testing can be determined. The presentation will give the updated status of the NIC Check Valve Performance Database covering (1) methodology used to combine the original ORNL data; (2) process/controls established for continuing update and refinement of the data; (3) discussion of how this data is being utilized by (a) OM-22 for condition monitoring, and (b) risk-based inservice testing work of Westinghouse Owners' Group; and (4) results/trends of data evaluations. At the 1994 Symposium, ORNL provided an update as of 1991 to their original work of 1984 -1990 which they had performed to characterize check valve degradations and failures in the nuclear industry. These characterizations will be updated to 1995 and additional reviews provided to give insight into the current condition and trends of check valve performance

  10. Quality Management Systems Implementation Compared With Organizational Maturity in Hospital.

    Science.gov (United States)

    Moradi, Tayebeh; Jafari, Mehdi; Maleki, Mohammad Reza; Naghdi, Seyran; Ghiasvand, Hesam

    2015-07-27

    A quality management system can provide a framework for continuous improvement in order to increase the probability of customers and other stakeholders' satisfaction. The test maturity model helps organizations to assess the degree of maturity in implementing effective and sustained quality management systems; plan based on the current realities of the organization and prioritize their improvement programs. We aim to investigate and compare the level of organizational maturity in hospitals with the status of quality management systems implementation. This analytical cross sectional study was conducted among hospital administrators and quality experts working in hospitals with over 200 beds located in Tehran. In the first step, 32 hospitals were selected and then 96 employees working in the selected hospitals were studied. The data were gathered using the implementation checklist of quality management systems and the organization maturity questionnaire derived from ISO 10014. The content validity was calculated using Lawshe method and the reliability was estimated using test - retest method and calculation of Cronbach's alpha coefficient. The descriptive and inferential statistics were used to analyze the data using SPSS 18 software. According to the table, the mean score of organizational maturity among hospitals in the first stage of quality management systems implementation was equal to those in the third stage and hypothesis was rejected (p-value = 0.093). In general, there is no significant difference in the organizational maturity between the first and third level hospitals (in terms of implementation of quality management systems). Overall, the findings of the study show that there is no significant difference in the organizational maturity between the hospitals in different levels of the quality management systems implementation and in fact, the maturity of the organizations cannot be attributed to the implementation of such systems. As a result, hospitals

  11. Sustaining Exploration in Mature Basins

    International Nuclear Information System (INIS)

    Bayo, A.

    2002-01-01

    Exploration is a business like any other business driven by opportunity, resources and expectation of profit. Therefore, exploration will thrive anywhere the opportunities are significant, the resources are available and the outlook for profit (or value creation) is good. To sustain exploration activities anywhere, irrespective of the environment, there must be good understanding of the drivers of these key investment criteria. This paper will examine these investment criteria as they relate to exploration business and address the peculiarity of exploration in mature basin. Mature basins are unique environment that lends themselves a mix of fears, paradigms and realities, particularly with respect to the perception of value. To sustain exploration activities in a mature basin, we need to understand these perceptions relative to the true drivers of profitability. Exploration in the mature basins can be as profitable as exploration in emerging basins if the dynamics of value definition-strategic and fiscal values are understood by operators, regulators and co ventures alike. Some suggestions are made in this presentation on what needs to be done in addressing these dynamic investment parameters and sustaining exploration activities in mature basins

  12. Public Sector IS Maturity Models

    DEFF Research Database (Denmark)

    Zinner Henriksen, Helle; Andersen, Kim Normann; Medaglia, Rony

    2011-01-01

    Online applications and processing of tax forms, driver licenses, and construction permits are examples of where policy attention and research have been united in efforts aiming to categorize the maturity level of e-services. Less attention has been attributed to policy areas with continuous online...... citizenpublic interaction, such as in public education. In this paper we use a revised version of the Public Sector Process Rebuilding (PPR) maturity model for mapping 200 websites of public primary schools in Denmark. Findings reveal a much less favorable picture of the digitization of the Danish public sector...... compared to the high ranking it has received in the international benchmark studies. This paper aims at closing the gap between the predominant scope of maturity models and the frequency of citizen-public sector interaction, and calls for increased attention to the activities of government where the scale...

  13. Bicarbonate Transport During Enamel Maturation.

    Science.gov (United States)

    Yin, Kaifeng; Paine, Michael L

    2017-11-01

    Amelogenesis (tooth enamel formation) is a biomineralization process consisting primarily of two stages (secretory stage and maturation stage) with unique features. During the secretory stage, the inner epithelium of the enamel organ (i.e., the ameloblast cells) synthesizes and secretes enamel matrix proteins (EMPs) into the enamel space. The protein-rich enamel matrix forms a highly organized architecture in a pH-neutral microenvironment. As amelogenesis transitions to maturation stage, EMPs are degraded and internalized by ameloblasts through endosomal-lysosomal pathways. Enamel crystallite formation is initiated early in the secretory stage, however, during maturation stage the more rapid deposition of calcium and phosphate into the enamel space results in a rapid expansion of crystallite length and mineral volume. During maturation-stage amelogenesis, the pH value of enamel varies considerably from slightly above neutral to acidic. Extracellular acid-base balance during enamel maturation is tightly controlled by ameloblast-mediated regulatory networks, which include significant synthesis and movement of bicarbonate ions from both the enamel papillary layer cells and ameloblasts. In this review we summarize the carbonic anhydrases and the carbonate transporters/exchangers involved in pH regulation in maturation-stage amelogenesis. Proteins that have been shown to be instrumental in this process include CA2, CA6, CFTR, AE2, NBCe1, SLC26A1/SAT1, SLC26A3/DRA, SLC26A4/PDS, SLC26A6/PAT1, and SLC26A7/SUT2. In addition, we discuss the association of miRNA regulation with bicarbonate transport in tooth enamel formation.

  14. Common tester platform concept.

    Energy Technology Data Exchange (ETDEWEB)

    Hurst, Michael James

    2008-05-01

    This report summarizes the results of a case study on the doctrine of a common tester platform, a concept of a standardized platform that can be applicable across the broad spectrum of testing requirements throughout the various stages of a weapons program, as well as across the various weapons programs. The common tester concept strives to define an affordable, next-generation design that will meet testing requirements with the flexibility to grow and expand; supporting the initial development stages of a weapons program through to the final production and surveillance stages. This report discusses a concept investing key leveraging technologies and operational concepts combined with prototype tester-development experiences and practical lessons learned gleaned from past weapons programs.

  15. Chromatin Regulation of Neuronal Maturation and Plasticity.

    Science.gov (United States)

    Gallegos, David A; Chan, Urann; Chen, Liang-Fu; West, Anne E

    2018-05-01

    Neurons are dynamic cells that respond and adapt to stimuli throughout their long postmitotic lives. The structural and functional plasticity of neurons requires the regulated transcription of new gene products, and dysregulation of transcription in either the developing or adult brain impairs cognition. We discuss how mechanisms of chromatin regulation help to orchestrate the transcriptional programs that underlie the maturation of developing neurons and the plasticity of adult neurons. We review how chromatin regulation acts locally to modulate the expression of specific genes and more broadly to coordinate gene expression programs during transitions between cellular states. These data highlight the importance of epigenetic transcriptional mechanisms in postmitotic neurons. We suggest areas where emerging methods may advance understanding in the future. Copyright © 2018 Elsevier Ltd. All rights reserved.

  16. A study of elementary teachers' conceptions of nature of science and their beliefs about the developmental appropriateness and importance of nature of science throughout a professional development program

    Science.gov (United States)

    Adibelli, Elif

    This qualitative study aimed to explore the changes in elementary science teachers' conceptions of nature of science (NOS) and their beliefs about the developmental appropriateness and importance of NOS after participating in an academic, year-long professional development program (PDP) as well as the factors facilitating these changes. The PDP consisted of two phases. In the first phase, the participants received NOS training designed with an explicit-reflective instructional approach. In the second phase, the participants implemented several NOS training activities in their classrooms. Four elementary science teachers who volunteered and completed all components of the PDP (i.e., the NOS training and the NOS teaching) comprised the participants of the present study. A multiple-embedded case study design was employed to explore the changes in the elementary science teachers' conceptions of NOS and their beliefs about the developmental appropriateness and importance of NOS. The study data were collected from multiple sources. The primary data sources included (a) Views of Nature of Science Elementary School Version 2 (VNOS-D2) questionnaire (Lederman & Khishfe, 2002), (b) Ideas about Science for Early Elementary (K-4) Students questionnaire (Sweeney, 2010), and (c) follow-up semi-structured interviews. The secondary data sources included videotaping of meetings with teachers, reflective field notes, and artifacts produced by teachers and their students. Data were analyzed using Yin's (1994, 2003) analytic tactics of pattern matching, explanation building, and cross-case synthesis. The findings of the study revealed that the elementary science teachers showed gradual, but substantial changes in their conceptions, and beliefs about the developmental appropriateness and importance of the NOS aspects over the course of participation in the PDP. Moreover, the participants identified nine components in the PDP that facilitated these changes in their conceptions, and

  17. Concept medium programme

    DEFF Research Database (Denmark)

    Bjerrum, Peter

    2005-01-01

    The present essay is an attempt to determine the architectural project of the 21st century in relation to a modern conception of space as the medium of architecture, and of sociality as its program......The present essay is an attempt to determine the architectural project of the 21st century in relation to a modern conception of space as the medium of architecture, and of sociality as its program...

  18. 1993 triggered lighnting test program: Environments within 20 meters of the lighting channel and small area temporary protection concepts

    Energy Technology Data Exchange (ETDEWEB)

    Fisher, R.J.; Schnetzer, G.H.

    1994-03-01

    Vertical electric fields, azimuthal magnetic fields, and earth step potentials at ground level have been measured at 10 and 20 meters from the base of triggered lightning flashes. For incident stroke peak currents in the range of 4.4 to 29 kA, vertical electric field change amplitudes as high as 210 kV/m were observed at 10 m, with rise times of the order of a few microseconds. Magnetic fields were found to follow Ampere`s law closely at both 10 and 20 m. Earth step potentials measured over a 0.5-m radial distance at the 10-m and 20m stations were linear with and had the same waveforms as the stroke currents. The step voltages exhibited a l/r distance dependence between the two measurement distances. A model that incorporates the presence of a thin surface layer, due to rain water saturation, of much higher conductivity than the bulk of the underlying earth is proposed to explain the observed behavior. Tests were also carried out to evaluate the effectiveness of several concepts for protecting a small exposed object, such as a piece of ordnance at the site of a transportation accident, from either a direct strike or from the indirect effects of electromagnetic fields produced by a nearby lightning flash to ground. Photographs of the occurrence of significant radial filamentary arcing along the surface of the ground from the strike points were acquired. This type of arcing, with a maximum radial extent of at least 20 m, was observed on six of seven of triggered flashes and on all strokes of 15-kA peak amplitude or higher.

  19. Motivational Maturity and Helping Behavior

    Science.gov (United States)

    Haymes, Michael; Green, Logan

    1977-01-01

    Maturity in conative development (type of motivation included in Maslow's needs hierarchy) was found to be predictive of helping behavior in middle class white male college students. The effects of safety and esteem needs were compared, and the acceptance of responsibility was also investigated. (GDC)

  20. Regulators of growth plate maturation

    NARCIS (Netherlands)

    Emons, Joyce Adriana Mathilde

    2010-01-01

    Estrogen is known to play an important role in longitudinal bone growth and growth plate maturation, but the mechanism by which estrogens exert their effect is not fully understood. In this thesis this role is further explored. Chapter 1 contains a general introduction to longitudinal bone growth

  1. Enhancing the effectiveness of HIV/AIDS prevention programs targeted to unique population groups in Thailand: lessons learned from applying concepts of diffusion of innovation and social marketing.

    Science.gov (United States)

    Svenkerud, P J; Singhal, A

    1998-01-01

    Diffusion of innovations theory and social marketing theory have been criticized for their limited applicability in influencing unique population groups (e.g., female commercial sex workers (CSWs) working in low-class brothels). This study investigated the applicability of these two theoretical frameworks in outreach efforts directed to unique populations at high risk for HIV/AIDS in Bangkok, Thailand. Further, this study examined Thai cultural characteristics that influence communication about HIV/AIDS prevention. The results suggest that certain concepts and strategies drawn from the two frameworks were used more or less by effective outreach programs, providing several policy-relevant lessons. Cultural constraints, such as the lack of visibility of the disease and traditional sexual practices, influenced communication about HIV/AIDS prevention.

  2. Using measures of wellbeing for impact evaluation: Proof of concept developed with an Indigenous community undertaking land management programs in northern Australia.

    Science.gov (United States)

    Larson, Silva; Stoeckl, Natalie; Jarvis, Diane; Addison, Jane; Prior, Sharon; Esparon, Michelle

    2018-05-05

    Combining insights from literature on the Theory of Change, Impact Evaluation, and Wellbeing, we develop a novel approach to assessing impacts. Intended beneficiaries identify and rate factors that are important to their wellbeing, their satisfaction with those factors now, and before an intervention. Qualitative responses to questions about perceived changes and causes of change are linked to quantitative data to draw inferences about the existence and/or importance of impact(s). We use data from 67 Ewamian people, in a case study relating to Indigenous land management, to provide proof of concept. 'Knowing that country is being looked after' and 'Having legal right/access to the country' were identified as important to wellbeing, with perceptions that Native Title determination, declared Indigenous Protected Area and associated land management programs have had a significant and positive impact on them. Further method testing might determine the utility of this approach in a wide range of settings.

  3. The effects of a group based stress treatment program (the Kalmia concept) targeting stress reduction and return to work. A randomized, wait-list controlled trial

    DEFF Research Database (Denmark)

    Netterstrøm, Bo; Friebel, Lene; Ladegaard, Yun Katrine

    2012-01-01

    Abstract Objective The aim of this study was to evaluate the effects of a group based multidisciplinary stress treatment program on reductions in symptom levels and the return to work (RTW) rate. Methods General practitioners referred 199 patients with persistent work related stress symptoms...... to the project. The inclusion criteria included being employed and being on sick leave. Using a randomized wait- list control design, the participants were randomized into three groups: the intervention group (IG, 70 participants) was treated using the Stress Therapy Concept of Kalmia, which consists...... to the WLCG . Further, the prevalence of depression declined significantly in the IG and the TAUCG compared to the WLCG. Regarding the RTW rate, 66% of the participants in the IG had returned to full time work after three months. This rate was significantly greater than the percentage in the TAUCG (36...

  4. Improving the human readability of Arden Syntax medical logic modules using a concept-oriented terminology and object-oriented programming expressions.

    Science.gov (United States)

    Choi, Jeeyae; Bakken, Suzanne; Lussier, Yves A; Mendonça, Eneida A

    2006-01-01

    Medical logic modules are a procedural representation for sharing task-specific knowledge for decision support systems. Based on the premise that clinicians may perceive object-oriented expressions as easier to read than procedural rules in Arden Syntax-based medical logic modules, we developed a method for improving the readability of medical logic modules. Two approaches were applied: exploiting the concept-oriented features of the Medical Entities Dictionary and building an executable Java program to replace Arden Syntax procedural expressions. The usability evaluation showed that 66% of participants successfully mapped all Arden Syntax rules to Java methods. These findings suggest that these approaches can play an essential role in the creation of human readable medical logic modules and can potentially increase the number of clinical experts who are able to participate in the creation of medical logic modules. Although our approaches are broadly applicable, we specifically discuss the relevance to concept-oriented nursing terminologies and automated processing of task-specific nursing knowledge.

  5. Applying the concept of quality of life to Israeli special education programs: a national curriculum for enhanced autonomy in students with special needs.

    Science.gov (United States)

    Reiter, Shunit; Schalock, Robert L

    2008-03-01

    This study provides a description of the design and development of guidelines and programs for a national core curriculum for special education in Israel. Israel was exposed during the 1970s to the ideology of normalization. Later on, toward the end of the 1980s, the concept of quality of life was added. Several research studies were conducted, resulting in the following core ideas about education: a shift of emphasis from teaching independent-living skills to teaching autonomy, self-awareness, self-direction, and interdependence is required. On the basis of these ideas, a new model of instruction was devised and termed the 'cycle of internalized learning' (CIL). The CIL is based on a holistic orientation toward the student and builds on abilities rather than disabilities. The peer group is the basic unit of instruction. Attention is on processes and outcomes. The CIL involves several clearly defined teaching steps: (i) opening--the presentation of the subject matter; (ii) discussion--a conceptual analysis of the subject; (iii) open conversation--students discuss the issues they raised during the first session, express their personal life experiences while applying the new concepts they learned, and suggest possible solutions to problems; (iv) trying out the solutions suggested by students; and (v) repeated discussions, to arrive at personal and social conclusions. Currently there are three published units of the CIL: (i) Social Education, (ii) Career Education, and (iii) Towards Leaving Home for Independent Living in the Community. The fourth unit, on citizenship education through the use of computers, is in its final stages of preparation. The success of the implementation of the program is expressed both at the students' level--as an enhanced sense of self-worth and self-confidence, as well as enhanced academic achievements and social skills--and at the teachers' level--as a paradigm shift from a medical model of approach to students with disabilities to a

  6. Summary of International Waste Management Programs (LLNL Input to SNL L3 MS: System-Wide Integration and Site Selection Concepts for Future Disposition Options for HLW)

    Energy Technology Data Exchange (ETDEWEB)

    Greenberg, Harris R. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Blink, James A. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Halsey, William G. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Sutton, Mark [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States)

    2011-08-11

    The Used Fuel Disposition Campaign (UFDC) within the Department of Energy’s Office of Nuclear Energy (DOE-NE) Fuel Cycle Technology (FCT) program has been tasked with investigating the disposal of the nation’s spent nuclear fuel (SNF) and high-level nuclear waste (HLW) for a range of potential waste forms and geologic environments. This Lessons Learned task is part of a multi-laboratory effort, with this LLNL report providing input to a Level 3 SNL milestone (System-Wide Integration and Site Selection Concepts for Future Disposition Options for HLW). The work package number is: FTLL11UF0328; the work package title is: Technical Bases / Lessons Learned; the milestone number is: M41UF032802; and the milestone title is: “LLNL Input to SNL L3 MS: System-Wide Integration and Site Selection Concepts for Future Disposition Options for HLW”. The system-wide integration effort will integrate all aspects of waste management and disposal, integrating the waste generators, interim storage, transportation, and ultimate disposal at a repository site. The review of international experience in these areas is required to support future studies that address all of these components in an integrated manner. Note that this report is a snapshot of nuclear power infrastructure and international waste management programs that is current as of August 2011, with one notable exception. No attempt has been made to discuss the currently evolving world-wide response to the tragic consequences of the earthquake and tsunami that devastated Japan on March 11, 2011, leaving more than 15,000 people dead and more than 8,000 people missing, and severely damaging the Fukushima Daiichi nuclear power complex. Continuing efforts in FY 2012 will update the data, and summarize it in an Excel spreadsheet for easy comparison and assist in the knowledge management of the study cases.

  7. Transitional Home Care program utilizing the Integrated Practice Unit concept (THC-IPU: Effectiveness in improving acute hospital utilization

    Directory of Open Access Journals (Sweden)

    Lian Leng Low

    2017-08-01

    Full Text Available Background: Organizing care into integrated practice units (IPUs around conditions and patient segments has been proposed to increase value. We organized transitional care into an IPU (THC-IPU for a patient segment of functionally dependent patients with limited community ambulation. Methods: 1,166 eligible patients were approached for enrolment into THC-IPU. THC-IPU patients received a comprehensive assessment within two weeks of discharge; medication reconciliation; education using standardized action plans and a dedicated nurse case manager for up to 90 days after discharge. Patients who rejected enrolment into THC-IPU received usual post-discharge care planned by their attending hospital physician, and formed the control group. The primary outcome was the proportion of patients with at least one unscheduled readmission within 30 days after discharge. Results: We found a statistically significant reduction in 30-day readmissions and emergency department visits in patients on THC-IPU care compared to usual care, even after adjusting for confounders. Conclusion: Delivering transitional care to patients with functional dependence in the form of home visits and organized into an IPU reduced acute hospital utilization in this patient segment. Extending the program into the pre-hospital discharge phase to include discharge planning can have incremental effectiveness in reducing avoidable hospital readmissions.

  8. Structural concept of angle type of hot isolation valve and its test program at an out-of-pile test facility

    Energy Technology Data Exchange (ETDEWEB)

    Hada, Kazuhiko; Fujisaki, Katsuo; Shibata, Taijyu; Inagaki, Yoshiyuki; Hino, Ryutaro [Japan Atomic Energy Research Inst., Oarai, Ibaraki (Japan). Oarai Research Establishment; Koiso, Hiroshi

    1997-02-01

    The Japanese safety regulation generally requires to set an isolation valve at the penetration of the reactor containment vessel on the secondary helium piping system which connects a steam reforming hydrogen production system, located outside the reactor building, to an intermediate heat exchanger (IHX) in the HTTR reactor system. The hot secondary helium which is heated up to the high temperature of 905degC and at the high pressure of 4.1MPa is passing through the isolation valve. So far, such a hot isolation valve has not been industrialized. The present report presents a proposal of a structural design concept of an angle valve as a promising candidate of the hot isolation valve, and a proposal on a test program for demonstrating the technological feasibility of the concept at an out-of-pile test facility before installing at the HTTR. A closing time and a leak rate at a valve seat are the key design parameters for developing the design concept. To set a reasonable value to each parameter, safety requirements on the isolation valve were discussed at first. The target closing time and the acceptable design limit of leak rate at the valve seat for meeting the requirements were specified 30 seconds and 10 STP cm{sup 3}/s, respectively. A nickel-base superalloy Hastelloy XR is feasible as such a valve seat material as to withstand the internal/external pressure of 4.1MPa at the high temperature of 905degC, the severest loading conditions of the valve seat at the accident of secondary helium pipe rupture. Correlation of leak rate at the ambient temperature to that at an operating temperature (900degC) is one of key test subjects of test program at an out-of-pile test facility. Leak rate at the operating temperature is the real parameter to be checked but only the leak rate at the ambient temperature is measured at regulatory examination in service. A test method to develop such correlation was proposed. (author)

  9. Assessment of skeletal maturation using mandibular second molar maturation stages.

    Science.gov (United States)

    Goyal, S; Goyal, S; Gugnani, N

    2014-01-01

    To investigate the relationship between cervical vertebrae maturation and mandibular second molar calcification stages. The study was designed as a retrospective, descriptive and crosssectional research project. Pre-treatment lateral cephalograms and panoramic radiographs of 99 males and 110 females in the age range of 7 to 18 years 7 months were evaluated with Demirjian Index (DI) and cervical vertebrae maturation indicators (CVMI) of Hassel and Farman. A null hypothesis was proposed that there is no relation between CVMI and DI. A highly significant association (Pearson's contingency coefficient 0.713 for males and 0.863 for females) was found between DI and CVMI. In males, the DI stage E corresponded to stage 2 of CVMI (pre-peak of pubertal growth spurt) and DI stages F and G corresponded to stages 3 and 4 of CVMI (peak of pubertal growth spurt). DI stage H was associated with stages 5 and 6 of CVMI (end of pubertal growth spurt). In females, the DI stages C, D corresponded to CVMI stages 1, 2; DI stages E, F with CVMI stages 3, 4; DI stages G, H with CVMI stages 5, 6. Mandibular second molar calcification stages can be used as indicators for assessment of skeletal maturity.

  10. Cervical vertebral maturation as a biologic indicator of skeletal maturity.

    Science.gov (United States)

    Santiago, Rodrigo César; de Miranda Costa, Luiz Felipe; Vitral, Robert Willer Farinazzo; Fraga, Marcelo Reis; Bolognese, Ana Maria; Maia, Lucianne Cople

    2012-11-01

    To identify and review the literature regarding the reliability of cervical vertebrae maturation (CVM) staging to predict the pubertal spurt. The selection criteria included cross-sectional and longitudinal descriptive studies in humans that evaluated qualitatively or quantitatively the accuracy and reproducibility of the CVM method on lateral cephalometric radiographs, as well as the correlation with a standard method established by hand-wrist radiographs. The searches retrieved 343 unique citations. Twenty-three studies met the inclusion criteria. Six articles had moderate to high scores, while 17 of 23 had low scores. Analysis also showed a moderate to high statistically significant correlation between CVM and hand-wrist maturation methods. There was a moderate to high reproducibility of the CVM method, and only one specific study investigated the accuracy of the CVM index in detecting peak pubertal growth. This systematic review has shown that the studies on CVM method for radiographic assessment of skeletal maturation stages suffer from serious methodological failures. Better-designed studies with adequate accuracy, reproducibility, and correlation analysis, including studies with appropriate sensitivity-specificity analysis, should be performed.

  11. Smart Grid Interoperability Maturity Model Beta Version

    Energy Technology Data Exchange (ETDEWEB)

    Widergren, Steven E.; Drummond, R.; Giroti, Tony; Houseman, Doug; Knight, Mark; Levinson, Alex; longcore, Wayne; Lowe, Randy; Mater, J.; Oliver, Terry V.; Slack, Phil; Tolk, Andreas; Montgomery, Austin

    2011-12-02

    The GridWise Architecture Council was formed by the U.S. Department of Energy to promote and enable interoperability among the many entities that interact with the electric power system. This balanced team of industry representatives proposes principles for the development of interoperability concepts and standards. The Council provides industry guidance and tools that make it an available resource for smart grid implementations. In the spirit of advancing interoperability of an ecosystem of smart grid devices and systems, this document presents a model for evaluating the maturity of the artifacts and processes that specify the agreement of parties to collaborate across an information exchange interface. You are expected to have a solid understanding of large, complex system integration concepts and experience in dealing with software component interoperation. Those without this technical background should read the Executive Summary for a description of the purpose and contents of the document. Other documents, such as checklists, guides, and whitepapers, exist for targeted purposes and audiences. Please see the www.gridwiseac.org website for more products of the Council that may be of interest to you.

  12. Concepts of formal concept analysis

    Science.gov (United States)

    Žáček, Martin; Homola, Dan; Miarka, Rostislav

    2017-07-01

    The aim of this article is apply of Formal Concept Analysis on concept of world. Formal concept analysis (FCA) as a methodology of data analysis, information management and knowledge representation has potential to be applied to a verity of linguistic problems. FCA is mathematical theory for concepts and concept hierarchies that reflects an understanding of concept. Formal concept analysis explicitly formalizes extension and intension of a concept, their mutual relationships. A distinguishing feature of FCA is an inherent integration of three components of conceptual processing of data and knowledge, namely, the discovery and reasoning with concepts in data, discovery and reasoning with dependencies in data, and visualization of data, concepts, and dependencies with folding/unfolding capabilities.

  13. Maturation of the adolescent brain

    Directory of Open Access Journals (Sweden)

    Arain M

    2013-04-01

    Full Text Available Mariam Arain, Maliha Haque, Lina Johal, Puja Mathur, Wynand Nel, Afsha Rais, Ranbir Sandhu, Sushil Sharma Saint James School of Medicine, Kralendijk, Bonaire, The Netherlands Abstract: Adolescence is the developmental epoch during which children become adults – intellectually, physically, hormonally, and socially. Adolescence is a tumultuous time, full of changes and transformations. The pubertal transition to adulthood involves both gonadal and behavioral maturation. Magnetic resonance imaging studies have discovered that myelinogenesis, required for proper insulation and efficient neurocybernetics, continues from childhood and the brain's region-specific neurocircuitry remains structurally and functionally vulnerable to impulsive sex, food, and sleep habits. The maturation of the adolescent brain is also influenced by heredity, environment, and sex hormones (estrogen, progesterone, and testosterone, which play a crucial role in myelination. Furthermore, glutamatergic neurotransmission predominates, whereas gamma-aminobutyric acid neurotransmission remains under construction, and this might be responsible for immature and impulsive behavior and neurobehavioral excitement during adolescent life. The adolescent population is highly vulnerable to driving under the influence of alcohol and social maladjustments due to an immature limbic system and prefrontal cortex. Synaptic plasticity and the release of neurotransmitters may also be influenced by environmental neurotoxins and drugs of abuse including cigarettes, caffeine, and alcohol during adolescence. Adolescents may become involved with offensive crimes, irresponsible behavior, unprotected sex, juvenile courts, or even prison. According to a report by the Centers for Disease Control and Prevention, the major cause of death among the teenage population is due to injury and violence related to sex and substance abuse. Prenatal neglect, cigarette smoking, and alcohol consumption may also

  14. Using concept mapping to explore why patients become lost to follow up from an antiretroviral therapy program in the Zomba District of Malawi.

    Science.gov (United States)

    Rachlis, Beth; Ahmad, Farah; van Lettow, Monique; Muula, Adamson S; Semba, Medson; Cole, Donald C

    2013-06-11

    Retention in antiretroviral therapy (ART) programmes remains a challenge in many settings including Malawi, in part due to high numbers of losses to follow-up. Concept Mapping (CM), a mix-method participatory approach, was used to explore why patients on ART are lost to follow-up (LTFU) by identifying: 1) factors that influence patient losses to follow-up and 2) barriers to effective and efficient tracing in Zomba, Malawi. CM sessions (brainstorming, sorting and rating, interpretation) were conducted in urban and rural settings in Zomba, Malawi. Participants included ART patients, ART providers, Health Surveillance Assistants, and health managers from the Zomba District Health Office. In brainstorming, participants generated statements in response to "A specific reason why an individual on ART becomes lost to follow-up is…" Participants then sorted and rated the consolidated list of brainstormed items. Analysis included inductive qualitative methods for grouping of data and quantitative cluster identification to produce visual maps which were then interpreted by participants. In total, 90 individuals brainstormed 371 statements, 64 consolidated statements were sorted (participant n = 46), and rated on importance and feasibility (participant n = 69). A nine-cluster concept map was generated and included both patient- and healthcare-related clusters such as: Stigma and Fears, Beliefs, Acceptance and Knowledge of ART, Access to ART, Poor Documentation, Social and Financial Support Issues, Health Worker Attitudes, Resources Needed for Effective Tracing, and Health Worker Issues Related to Tracing. Strategies to respond to the clusters were generated in Interpretation. Multiple patient- and healthcare focused factors influence why patients become LTFU. Findings have implications particularly for programs with limited resources struggling with the retention of ART patients.

  15. Assessment of fuel concepts

    International Nuclear Information System (INIS)

    Bailey, W.J.; Barner, J.O.

    1978-01-01

    The relative merits of various LWR UO 2 fuel concepts with the potential for improved power-ramping capability were qualitatively assessed. In the evaluation, it was determined that of the various concepts being considered, those that presently possess an adequately developed experience base include annular pellets, cladding coated with graphite on the inner surface, and packed-particle fuel. Therefore, these were selected for initial evaluation as part of the Fuel Performance Improvement Program. For this program, graphite-coated cladding is being used in conjunction with annular pellet fuel as one of the concepts with the anticipation of gaining the advantage of the combined improvements. The report discusses the following: the criteria used to evaluate the candidate fuel concepts; a comparison of the concepts selected for irradiation with the criteria, including a general description of their experience bases; and a general discussion of other candidate concepts, including identifying those which may be considered for out-of-reactor evaluation as part of this program, those for which the results of other programs will be monitored, and those which have been deleted from further consideration at this time

  16. Capability maturity models in engineering companies: case study analysis

    Directory of Open Access Journals (Sweden)

    Titov Sergei

    2016-01-01

    Full Text Available In the conditions of the current economic downturn engineering companies in Russia and worldwide are searching for new approaches and frameworks to improve their strategic position, increase the efficiency of the internal business processes and enhance the quality of the final products. Capability maturity models are well-known tools used by many foreign engineering companies to assess the productivity of the processes, to elaborate the program of business process improvement and to prioritize the efforts to optimize the whole company performance. The impact of capability maturity model implementation on cost and time are documented and analyzed in the existing research. However, the potential of maturity models as tools of quality management is less known. The article attempts to analyze the impact of CMM implementation on the quality issues. The research is based on a case study methodology and investigates the real life situation in a Russian engineering company.

  17. Social and moral maturity of high-school students

    Directory of Open Access Journals (Sweden)

    Silvana Gasar

    2005-02-01

    Full Text Available The level of social and moral maturity of high-school students was examined. There were almost no significant differences between the students of two different educational programs. In general, the students' level of social and moral maturity is satisfyingly high, but their social skills are not quite appropriately developed. The results of behaviour in school situations reveal a quite unpleasant picture of interpersonal relations, which is probably a reflection of social relations in society. The absence of correlations between both components of maturity and social skills shows the gap between human's reasoning and behaviour. Students know, which behaviour is moral and socially adapted, but they do not always act in congruence with that, because existing social relations often encourage different behaviour.

  18. Maturity Model of Software Product with Educational Maturity Model

    OpenAIRE

    R.Manjula; J.Vaideeswaran

    2011-01-01

    Software product line engineering is an inter-disciplinary concept. It spans the dimensions of business, architecture, process,and the organization. Similarly, Education System engineering is also an inter-disciplinary concept, which spans the dimensions of academic, infrastructure, facilities, administration etc. Some of the potential benefits of this approach includecontinuous improvements in System quality and adhering to global standards. The increasing competency in IT and Educational Se...

  19. 7 CFR 51.1904 - Maturity classification.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 2 2010-01-01 2010-01-01 false Maturity classification. 51.1904 Section 51.1904... STANDARDS) United States Consumer Standards for Fresh Tomatoes Size and Maturity Classification § 51.1904 Maturity classification. Tomatoes which are characteristically red when ripe, but are not overripe or soft...

  20. Social maturity of the identity of seniors as condition of successful adaptation to the modern sociocultural environment

    OpenAIRE

    Pavlov A.K.

    2017-01-01

    this article describes social maturity of the identity of seniors as a condition of successful adaptation to the modern sociocultural environment, marks out some criteria of definition of socially mature personality, gives definition to the concept «social competence of the personality».

  1. LEVEL SOCIAL SELF CONCEPT AND IMPLICATION IN GUIDANCE AND COUNSELING

    Directory of Open Access Journals (Sweden)

    Widya Kartika Sari

    2016-12-01

    Full Text Available Teenager consider themselves based on the perception others and one of the element which affecting the maturation in self concept is how the assessment and social environment revenue toward it self .This study purpose to describe the self concept of teens and the implications in guidance and counseling .The research type descriptive quantitative methods. The Research was done to teenagers of simple  orphanage in  bengkulu with a population about 103 teenagers .The total of the  research about 82 survey youth to the sample used purposive sampling techniqul  instrument was used  the closed of  scale likert model  with validity 0.873 , reliability ( 0,931 self concept .The findings of this research shows that: ( 1 self concept as of teens tend to be low category. (2  implications finding for service counseling guidance the basic of arranging the guidance counseling program service which can formed  and improved the self concept of teens positively.

  2. Change within Purchasing and Supply Management Organisations – Assessing the Claims from Maturity Models

    DEFF Research Database (Denmark)

    Holm Andreasen, Peter; Gammelgaard, Britta

    2018-01-01

    It is a wide-held assumption that professional development and change within purchasing and supply management (PSM) organisations can be explained and guided by a maturity model. In this paper the guidance which the maturity model concept offers to understand a PSM organisation's performance...... an organisational change framework, composing 1) movement transitions, 2) scalability of change, 3) acceptability of change, and 4) the substantive element of change. The research found that extant PSM maturity models are too rigid for PSM managers to apply, and although maturity models are commonly accepted in PSM...... is assessed. The methodology is based on the outcomes of a literature review of PSM maturity models, development of an organisational change framework and the learning from three qualitative case studies. An alternative understanding of the development of the PSM organisation is offered through...

  3. Academic Achievement of High School Students in Relation to Their Anxiety, Emotional Maturity and Social Maturity

    Science.gov (United States)

    Puar, Surjit Singh

    2013-01-01

    The present study has been designed to investigate the non-cognitive variables like anxiety, emotional maturity and social maturity and their relationship with academic achievement and also to see the locale-wise differences on the basis of their anxiety, emotional maturity and social maturity. The study was conducted over a sample of 400 (200…

  4. Evolutionistic or revolutionary paths? A PACS maturity model for strategic situational planning.

    Science.gov (United States)

    van de Wetering, Rogier; Batenburg, Ronald; Lederman, Reeva

    2010-07-01

    While many hospitals are re-evaluating their current Picture Archiving and Communication System (PACS), few have a mature strategy for PACS deployment. Furthermore, strategies for implementation, strategic and situational planning methods for the evolution of PACS maturity are scarce in the scientific literature. Consequently, in this paper we propose a strategic planning method for PACS deployment. This method builds upon a PACS maturity model (PMM), based on the elaboration of the strategic alignment concept and the maturity growth path concept previously developed in the PACS domain. First, we review the literature on strategic planning for information systems and information technology and PACS maturity. Secondly, the PMM is extended by applying four different strategic perspectives of the Strategic Alignment Framework whereupon two types of growth paths (evolutionistic and revolutionary) are applied that focus on a roadmap for PMM. This roadmap builds a path to get from one level of maturity and evolve to the next. An extended method for PACS strategic planning is developed. This method defines eight distinctive strategies for PACS strategic situational planning that allow decision-makers in hospitals to decide which approach best suits their hospitals' current situation and future ambition and what in principle is needed to evolve through the different maturity levels. The proposed method allows hospitals to strategically plan for PACS maturation. It is situational in that the required investments and activities depend on the alignment between the hospital strategy and the selected growth path. The inclusion of both strategic alignment and maturity growth path concepts make the planning method rigorous, and provide a framework for further empirical research and clinical practice.

  5. Genotype x environmental interaction for mature size and rate of maturing for Angus, Brahman, and reciprocal-cross cows grazing bermudagrass or endophyte infected fescue.

    Science.gov (United States)

    Sandelin, B A; Brown, A H; Brown, M A; Johnson, Z B; Kellogg, D W; Stelzleni, A M

    2002-12-01

    choice of breed type is important in maintaining a crossbreeding program, in that mature BW and rate of maturing are critical to the matching of animal requirements to available production resources.

  6. E-learning process maturity level: a conceptual framework

    Science.gov (United States)

    Rahmah, A.; Santoso, H. B.; Hasibuan, Z. A.

    2018-03-01

    ICT advancement is a sure thing with the impact influencing many domains, including learning in both formal and informal situations. It leads to a new mindset that we should not only utilize the given ICT to support the learning process, but also improve it gradually involving a lot of factors. These phenomenon is called e-learning process evolution. Accordingly, this study attempts to explore maturity level concept to provide the improvement direction gradually and progression monitoring for the individual e-learning process. Extensive literature review, observation, and forming constructs are conducted to develop a conceptual framework for e-learning process maturity level. The conceptual framework consists of learner, e-learning process, continuous improvement, evolution of e-learning process, technology, and learning objectives. Whilst, evolution of e-learning process depicted as current versus expected conditions of e-learning process maturity level. The study concludes that from the e-learning process maturity level conceptual framework, it may guide the evolution roadmap for e-learning process, accelerate the evolution, and decrease the negative impact of ICT. The conceptual framework will be verified and tested in the future study.

  7. Innovative confinement concepts workshop

    International Nuclear Information System (INIS)

    Kirkpatrick, R.C.

    1998-01-01

    The Innovative Confinement Concepts Workshop occurred in California during the week preceding the Second Symposium on Current Trends in International Fusion Research. An informal report was made to the Second Symposium. A summary of the Workshop concluded that some very promising ideas were presented, that innovative concept development is a central element of the restructured US DOE. Fusion Energy Sciences program, and that the Workshop should promote real scientific progress in fusion

  8. Separations innovative concepts: Project summary

    Energy Technology Data Exchange (ETDEWEB)

    Lee, V.E. (ed.)

    1988-05-01

    This project summary includes the results of 10 innovations that were funded under the US Department's Innovative Concept Programs. The concepts address innovations that can substantially reduce the energy used in industrial separations. Each paper describes the proposed concept, and discusses the concept's potential energy savings, market applications, technical feasibility, prior work and state of the art, and future development needs.

  9. Maturity Models Development in IS Research

    DEFF Research Database (Denmark)

    Lasrado, Lester Allan; Vatrapu, Ravi; Andersen, Kim Normann

    2015-01-01

    Maturity models are widespread in IS research and in particular, IT practitioner communities. However, theoretically sound, methodologically rigorous and empirically validated maturity models are quite rare. This literature review paper focuses on the challenges faced during the development...... literature reveals that researchers have primarily focused on developing new maturity models pertaining to domain-specific problems and/or new enterprise technologies. We find rampant re-use of the design structure of widely adopted models such as Nolan’s Stage of Growth Model, Crosby’s Grid, and Capability...... Maturity Model (CMM). Only recently have there been some research efforts to standardize maturity model development. We also identify three dominant views of maturity models and provide guidelines for various approaches of constructing maturity models with a standard vocabulary. We finally propose using...

  10. Flourishing: An Evolutionary Concept Analysis.

    Science.gov (United States)

    Agenor, Christine; Conner, Norma; Aroian, Karen

    2017-11-01

    Mental health is an important measure of public health (WHO, 2004); however, nursing practice and research continues to prioritize mental illness, rather than well-being (Wand, 2011). Flourishing is a recent concept in the field of well-being. The term has been used sparingly in nursing practice and research, and conceptual clarification is needed to promote comprehensive understanding of the phenomenon. The purpose of this study is to critically analyze flourishing, assess the maturity of the concept, and provide recommendations for future research, education, and practice. The concept of flourishing was analyzed using the evolutionary approach to concept analysis (Rodgers, 2000). A search for articles on flourishing within the context of well-being was conducted through CINAHL, MEDLINE, and PsycINFO. A sample of 32 articles and 1 book was reviewed. Data were reviewed for concept attributes, antecedents, consequences, surrogate terms and related concepts. Four models of flourishing were identified with six overlapping attributes: meaning, positive relationships, engagement, competence, positive emotion, and self-esteem. Limited longitudinal and predictive studies have been conducted, but there is evidence for several antecedents and outcomes of flourishing. Research is ongoing primarily in psychology and sociology and is lacking in other disciplines. The concept of flourishing is immature; however, evidence is building for related concepts. A lack of consistent terminology regarding flourishing prevents knowledge development of flourishing as a distinct concept. Further multidisciplinary research is needed to establish standard operational and conceptual definitions and develop effective interventions.

  11. Adnexal Torsion during Pregnancy after Oocyte In Vitro Maturation and Intracytoplasmic Sperm Injection Cycle

    Directory of Open Access Journals (Sweden)

    Simone Giulini

    2010-01-01

    Full Text Available We report a case of right adnexal torsion during pregnancy after an oocyte in vitro maturation and intracitoplasmic sperm injection cycle in patient with polycystic ovary syndrome. A 31-year-old woman with a typical clinical disorder of polycystic ovarian syndrome was included in an oocyte in vitro maturation program. Right adnexal torsion occurred two days after embryo transfer, and laparoscopy detorsion was successfully performed with preservation of adnexa. The patient had a full-term pregnancy and delivered a healthy infant at 40 weeks of gestation. To our knowledge this is the first report of adnexal torsion after an oocyte in vitro maturation and intracitoplasmic sperm injection program.

  12. Arnold Gesell and the maturation controversy.

    Science.gov (United States)

    Dalton, Thomas C

    2005-01-01

    This article examines the work of Arnold Lucius Gesell and argues that he not only paved the way for contemporary research in motor development, but that he and colleagues anticipated fundamental issues about growth that must be addressed by psychologists and neuroscientists who are committed to the advancement of developmental science. Arnold Lucius Gesell was a pioneer in developmental psychology when the field was in its infancy. He worked diligently for the rights of physically and mentally handicapped children to receive special education that would enable them to find gainful employment. Gesell's writings in books and popular magazines increased public awareness of and support for preschool education and better foster care for orphans. Despite these achievements, many of his successors have questioned his views about infant development. Developmental psychologists have criticized Gesell for proposing a stage theory of infant growth that has fallen into disfavor among contemporary researchers. His conception of development as a maturational process has been challenged for allegedly reducing complex behavioral, perceptual, and learning processes to genetic factors. The author rejects this overly simplistic interpretation and contends that Gesell's work continues to stand the test of time.

  13. Exploring the Dimensions of E-learning Maturity Model

    Directory of Open Access Journals (Sweden)

    George Maher Iskander

    2012-06-01

    Full Text Available Despite the highlighting on e-learning, it was obvious that models for successful deployment have not yet been recognized. Even with the huge quantities of money being spent, it is not clear that any enhancement in student learning outcomes has been recognized. To address this issue, this qualitative research aimed to explore and understand dimensions of E-learning Maturity Model (ELMM. An inductive approach, using qualitative methods, was used in this research. Fifty interviewees suggested five dimensions: Students' Attitudes, University attitudes from students’ perspectives, E-learning features, E-learning implementation and Effects of E-learning on students. Students from different majors and levels participated in this study. Findings of this study show that, there are significant five factors which formulate ELMM. Moreover, the study demonstrates that e-learning features have significant effects on student. It also highlights the relevance of using qualitative research in exploring maturity concept in e- learning.

  14. Maturity group classification and maturity locus genotyping of early-maturing soybean varieties from high-latitude cold regions.

    Science.gov (United States)

    Jia, Hongchang; Jiang, Bingjun; Wu, Cunxiang; Lu, Wencheng; Hou, Wensheng; Sun, Shi; Yan, Hongrui; Han, Tianfu

    2014-01-01

    With the migration of human beings, advances of agricultural sciences, evolution of planting patterns and global warming, soybeans have expanded to both tropical and high-latitude cold regions (HCRs). Unlike other regions, HCRs have much more significant and diverse photoperiods and temperature conditions over seasons or across latitudes, and HCR soybeans released there show rich diversity in maturity traits. However, HCR soybeans have not been as well classified into maturity groups (MGs) as other places. Therefore, it is necessary to identify MGs in HCRs and to genotype the maturity loci. Local varieties were collected from the northern part of Northeast China and the far-eastern region of Russia. Maturity group reference (MGR) soybeans of MGs MG000, MG00, and MG0 were used as references during field experiments. Both local varieties and MGR soybeans were planted for two years (2010-2011) in Heihe (N 50°15', E 127°27', H 168.5 m), China. The days to VE (emergence), R1 (beginning bloom) and R7 (beginning maturity) were recorded and statistically analyzed. Furthermore, some varieties were further genotyped at four molecularly-identified maturity loci E1, E2, E3 and E4. The HCR varieties were classified into MG0 or even more early-maturing. In Heihe, some varieties matured much earlier than MG000, which is the most early-maturing known MG, and clustered into a separate group. We designated the group as MG0000, following the convention of MGs. HCR soybeans had relatively stable days to beginning bloom from emergence. The HCR varieties diversified into genotypes of E1, E2, E3 and E4. These loci had different effects on maturity. HCRs diversify early-maturing MGs of soybean. MG0000, a new MG that matures much earlier than known MGs, was developed. HCR soybean breeding should focus more on shortening post-flowering reproductive growth. E1, E2, E3, and E4 function differentially.

  15. Il Concetto di Infinito nell'Intuizione Matematica (Concept of Infinity in Mathematical Intuition).

    Science.gov (United States)

    Ferrari, E.; And Others

    1995-01-01

    Investigated the acquisition and maturation of the infinity concept in mathematics of students ages 13-15. Found the infinity concept is learned by students only when provided with appropriate guidance. (Author/MKR)

  16. COMET concept

    International Nuclear Information System (INIS)

    Alsmeyer, H.; Tromm, W.

    1995-01-01

    Studies of the COMET core catcher concept developed for a future PWR have been continued. The concept is based on the spreading of a core melt on a sacrificial layer and its erosion, until a subsequent addition of water from below causes a fragmentation of the melt. A porous solidification of the melt would then admit a complete flooding within a short period. (orig.)

  17. Concept Mapping

    Science.gov (United States)

    Technology & Learning, 2005

    2005-01-01

    Concept maps are graphical ways of working with ideas and presenting information. They reveal patterns and relationships and help students to clarify their thinking, and to process, organize and prioritize. Displaying information visually--in concept maps, word webs, or diagrams--stimulates creativity. Being able to think logically teaches…

  18. Management concepts.

    Science.gov (United States)

    Bittner, Rhonda

    2006-01-01

    Management concepts evolve through time. Health care managers can learn new concepts by evaluating classical management strategies, as well as modern-day strategies. Focusing on quality improvement and team building can help managers align the goals of their departments with the goals of the organization, consequently improving patient care.

  19. Lateral Concepts

    DEFF Research Database (Denmark)

    Gad, Christopher; Bruun Jensen, casper

    2016-01-01

    This essay discusses the complex relation between the knowledges and practices of the researcher and his/her informants in terms of lateral concepts. The starting point is that it is not the prerogative of the (STS) scholar to conceptualize the world; all our “informants” do it too. This creates...... the possibility of enriching our own conceptual repertoires by letting them be inflected by the concepts of those we study. In a broad sense, the lateral means that there is a many-to-many relation between domains of knowledge and practice. However, each specific case of the lateral is necessarily immanent...... to a particular empirical setting and form of inquiry. In this sense lateral concepts are radically empirical since it locates concepts within the field. To clarify the meaning and stakes of lateral concepts, we first make a contrast between lateral anthropology and Latour’s notion of infra-reflexivity. We end...

  20. Concept theory

    DEFF Research Database (Denmark)

    Hjørland, Birger

    2009-01-01

      Concept theory is an extremely broad, interdisciplinary and complex field of research related to many deep fields with very long historical traditions without much consensus. However, information science and knowledge organization cannot avoid relating to theories of concepts. Knowledge...... organizing systems (e.g. classification systems, thesauri and ontologies) should be understood as systems basically organizing concepts and their semantic relations. The same is the case with information retrieval systems. Different theories of concepts have different implications for how to construe......, evaluate and use such systems. Based on "a post-Kuhnian view" of paradigms this paper put forward arguments that the best understanding and classification of theories of concepts is to view and classify them in accordance with epistemological theories (empiricism, rationalism, historicism and pragmatism...

  1. A maturity model for blockchain adoption

    OpenAIRE

    Wang, Huaiqing; Chen, Kun; Xu, Dongming

    2016-01-01

    Background: The rapid development of the blockchain technology and its various applications has rendered it important to understand the guidelines for adopting it. Methods: The comparative analysis method is used to analyze different dimensions of the maturity model, which is mainly based on the commonly used capability maturity model. Results: The blockchain maturity model and its adoption process have been discussed and presented. Conclusions: This study serves as a guide to institutions to...

  2. A Set Theoretical Approach to Maturity Models

    DEFF Research Database (Denmark)

    Lasrado, Lester; Vatrapu, Ravi; Andersen, Kim Normann

    2016-01-01

    characterized by equifinality, multiple conjunctural causation, and case diversity. We prescribe methodological guidelines consisting of a six-step procedure to systematically apply set theoretic methods to conceptualize, develop, and empirically derive maturity models and provide a demonstration......Maturity Model research in IS has been criticized for the lack of theoretical grounding, methodological rigor, empirical validations, and ignorance of multiple and non-linear paths to maturity. To address these criticisms, this paper proposes a novel set-theoretical approach to maturity models...

  3. The LDC detector concept

    Indian Academy of Sciences (India)

    Abstract. In preparation of the experimental program at the international linear collider (ILC), the large detector concept (LDC) is being developed. The main points of the LDC are a large volume gaseous tracking system, combined with high precision vertex detector and an extremely granular calorimeter. The main design ...

  4. Sexual maturation in the Sumatran rhinoceros (Dicerorhinus sumatrensis).

    Science.gov (United States)

    Roth, Terri L; Reinhart, Paul R; Romo, John S; Candra, Dedi; Suhaery, Andriansyah; Stoops, Monica A

    2013-01-01

    To help save the Sumatran rhino from extinction, the captive breeding program must capitalize on each rhino's reproductive lifespan. Doing so requires knowing when calves are sexually mature. The goal of this study was to monitor physiological changes associated with sexual maturation in two captive born calves (one male and one female) to determine the approximate age of maturity for both sexes of this species. Fecal testosterone metabolites were monitored in the male calf from 6 months to 7 years of age, and fecal pregnane metabolites were measured in the female calf from 6 months to 5.5 years of age. In addition, rectal ultrasonography was employed to monitor changes in ovarian activity from 2 to 5.5 years of age. The male calf's fecal testosterone concentrations reached levels comparable to those detected in samples from adult males when he was 6-6.5 years of age. The first pre-ovulatory sized follicle was observed on the ovaries of the female calf when she was 4.75 years old, but fecal pregnane metabolite concentrations only reached maximum mean concentrations and variability when she was 5-5.5 years of age. Results from this study indicate that male and female Sumatran rhino calves are sexually mature at 6-6.5 and 5-5.5 years of age, respectively. © 2013 Wiley Periodicals, Inc.

  5. Programming

    International Nuclear Information System (INIS)

    Jackson, M.A.

    1982-01-01

    The programmer's task is often taken to be the construction of algorithms, expressed in hierarchical structures of procedures: this view underlies the majority of traditional programming languages, such as Fortran. A different view is appropriate to a wide class of problem, perhaps including some problems in High Energy Physics. The programmer's task is regarded as having three main stages: first, an explicit model is constructed of the reality with which the program is concerned; second, this model is elaborated to produce the required program outputs; third, the resulting program is transformed to run efficiently in the execution environment. The first two stages deal in network structures of sequential processes; only the third is concerned with procedure hierarchies. (orig.)

  6. The technological conception

    International Nuclear Information System (INIS)

    Parrochia, D.

    1998-01-01

    The 'technological conception' examines how a project can be concretized or how it is possible to 'conceive', i.e. to produce operative ideas that can be directly use. The first part of this book, called 'concepts and methods', analyzes the logics of conceiving and its philosophy in the construction of its objects and in the management of its programs or projects. The second part is devoted to some exemplary technologies: roads, tunnels, bridges, dams, nuclear power plants, aerospace constructions, and analyzes different concrete logics of technological conception. Finally, the author shows how todays conception faces the risks and complexity increase of systems and considers the possibility of an entirely automated manufacturing shop in the future. (J.S.)

  7. Programming

    OpenAIRE

    Jackson, M A

    1982-01-01

    The programmer's task is often taken to be the construction of algorithms, expressed in hierarchical structures of procedures: this view underlies the majority of traditional programming languages, such as Fortran. A different view is appropriate to a wide class of problem, perhaps including some problems in High Energy Physics. The programmer's task is regarded as having three main stages: first, an explicit model is constructed of the reality with which the program is concerned; second, thi...

  8. Automation Hooks Architecture for Flexible Test Orchestration - Concept Development and Validation

    Science.gov (United States)

    Lansdowne, C. A.; Maclean, John R.; Winton, Chris; McCartney, Pat

    2011-01-01

    The Automation Hooks Architecture Trade Study for Flexible Test Orchestration sought a standardized data-driven alternative to conventional automated test programming interfaces. The study recommended composing the interface using multicast DNS (mDNS/SD) service discovery, Representational State Transfer (Restful) Web Services, and Automatic Test Markup Language (ATML). We describe additional efforts to rapidly mature the Automation Hooks Architecture candidate interface definition by validating it in a broad spectrum of applications. These activities have allowed us to further refine our concepts and provide observations directed toward objectives of economy, scalability, versatility, performance, severability, maintainability, scriptability and others.

  9. The Sandia MEMS passive shock sensor : FY07 maturation activities.

    Energy Technology Data Exchange (ETDEWEB)

    Houston, Jack E.; Blecke, Jill; Mitchell, John Anthony; Wittwer, Jonathan W.; Crowson, Douglas A.; Clemens, Rebecca C.; Walraven, Jeremy Allen; Epp, David S.; Baker, Michael Sean

    2008-08-01

    This report describes activities conducted in FY07 to mature the MEMS passive shock sensor. The first chapter of the report provides motivation and background on activities that are described in detail in later chapters. The second chapter discusses concepts that are important for integrating the MEMS passive shock sensor into a system. Following these two introductory chapters, the report details modeling and design efforts, packaging, failure analysis and testing and validation. At the end of FY07, the MEMS passive shock sensor was at TRL 4.

  10. Travelling Concepts

    DEFF Research Database (Denmark)

    Simonsen, Karen-Margrethe

    2013-01-01

    Review of "Travelling Concepts, Metaphors, and Narratives: Literary and Cultural Studies in an Age of Interdisciplinary Research" ed. by Sibylle Baumgarten, Beatrice Michaelis and Ansagar Nünning, Trier; Wissenschaftlicher Verlag Trier, 2012......Review of "Travelling Concepts, Metaphors, and Narratives: Literary and Cultural Studies in an Age of Interdisciplinary Research" ed. by Sibylle Baumgarten, Beatrice Michaelis and Ansagar Nünning, Trier; Wissenschaftlicher Verlag Trier, 2012...

  11. Developmental insights into mature cognition.

    Science.gov (United States)

    Keil, Frank C

    2015-02-01

    Three cases are described that illustrate new ways in which developmental research is informing the study of cognition in adults: statistical learning, neural substrates of cognition, and extended concepts. Developmental research has made clear the ubiquity of statistical learning while also revealing is limitations as a stand-alone way to acquire knowledge. With respect to neural substrates, development has uncovered links between executive processing and fronto-striatal circuits while also pointing to many aspects of high-level cognition that may not be neatly reducible to coherent neural descriptions. For extended concepts, children have made especially clear the weaknesses of intuitive theories in both children and adults while also illustrating other cognitive capacities that are used at all ages to navigate the socially distributed aspects of knowledge. Copyright © 2014 Elsevier B.V. All rights reserved.

  12. e-Government Maturity Model Based on Systematic Review and Meta-Ethnography Approach

    Directory of Open Access Journals (Sweden)

    Darmawan Napitupulu

    2016-11-01

    Full Text Available Maturity model based on e-Government portal has been developed by a number of researchers both individually and institutionally, but still scattered in various journals and conference articles and can be said to have a different focus with each other, both in terms of stages and features. The aim of this research is conducting a study to integrate a number of maturity models existing today in order to build generic maturity model based on e-Government portal. The method used in this study is Systematic Review with meta-ethnography qualitative approach. Meta-ethnography, which is part of Systematic Review method, is a technique to perform data integration to obtain theories and concepts with a new level of understanding that is deeper and thorough. The result obtained is a maturity model based on e-Government portal that consists of 7 (seven stages, namely web presence, interaction, transaction, vertical integration, horizontal integration, full integration, and open participation. These seven stages are synthesized from the 111 key concepts related to 25 studies of maturity model based e-Government portal. The maturity model resulted is more comprehensive and generic because it is an integration of models (best practices that exists today.

  13. Increasing Educational Achievement via Self Concept Change.

    Science.gov (United States)

    Scheirer, Mary Ann; Kraut, Robert E.

    1979-01-01

    Literature linking self-concept and achievement, and evaluation research on educational programs to improve self-concept are analyzed in terms of several self-concept theories. Evidence for a causal connection between self-concept and achievement is negative. Researchers have failed to explore other theoretical approaches to educational change.…

  14. Motivational maturity and helping behavior.

    Science.gov (United States)

    Haymes, M; Green, L

    1977-12-01

    This study was undertaken to examine the independent influences of conative development (the Maslow needs hierarchy) upon behavioral aspects of prosocial orientations. It provides a behavioral demonstration of conative effects in a helping paradigm, among college-age men. A comparison of the conative data across the ages of 15-22 provided a cross-sectional view of conative development itself. Conative maturity was found to be predictive of greater helping among college-age men. Situational demands were demonstrated which tended to mask, but not override, these predispositional influences on helping. The cross-sectional data on conative development point to probable movement to early esteem concerns among high school men who have reached the conative level of love and belonging. On the other hand, the stability across the years of 15-22 of proportion of safety concerns suggests fixation of such concerns in those exhibiting them in high school. Results are discussed in terms of conative growth for development of prosocial orientations.

  15. Smart Grid Interoperability Maturity Model

    Energy Technology Data Exchange (ETDEWEB)

    Widergren, Steven E.; Levinson, Alex; Mater, J.; Drummond, R.

    2010-04-28

    The integration of automation associated with electricity resources (including transmission and distribution automation and demand-side resources operated by end-users) is key to supporting greater efficiencies and incorporating variable renewable resources and electric vehicles into the power system. The integration problems faced by this community are analogous to those faced in the health industry, emergency services, and other complex communities with many stakeholders. To highlight this issue and encourage communication and the development of a smart grid interoperability community, the GridWise Architecture Council (GWAC) created an Interoperability Context-Setting Framework. This "conceptual model" has been helpful to explain the importance of organizational alignment in addition to technical and informational interface specifications for "smart grid" devices and systems. As a next step to building a community sensitive to interoperability, the GWAC is investigating an interoperability maturity model (IMM) based on work done by others to address similar circumstances. The objective is to create a tool or set of tools that encourages a culture of interoperability in this emerging community. The tools would measure status and progress, analyze gaps, and prioritize efforts to improve the situation.

  16. Antenatal assessment of fetal maturity

    International Nuclear Information System (INIS)

    Gerstner, G.; Reinold, E.; Wolf, G.

    1979-01-01

    334 ultrasound-cephalometries and 231 X-ray fetographies were performed for antenatal assessment of fetal maturity as well as for exact estimation of gestational age in women with unknown date of confinement. The accuracy of the predictions was compared. Ultrasound-cephalometry gave best results when performed until the 20th week of gestation. A correct prediction was obtained in 80.4% of cases. After the 20th week of gestation, the accuracy of prediction decreased. Radiology on the contrary gave optimal results at the end of pregnancy. A correct prediction of the date of confinement was obtained in 73.8% of cases, when the X-ray fetography was performed between the 37th and 40th week of gestation. At the end of gestation radiography should be performed, if there is a discrepancy between ultrasound and clinical estimation or if ultrasound-cephalometry was not carried out in early pregnancy - especially if induction of labour is necessary. (author)

  17. Refinement of the concept of uncertainty.

    Science.gov (United States)

    Penrod, J

    2001-04-01

    To analyse the conceptual maturity of uncertainty; to develop an expanded theoretical definition of uncertainty; to advance the concept using methods of concept refinement; and to analyse congruency with the conceptualization of uncertainty presented in the theory of hope, enduring, and suffering. Uncertainty is of concern in nursing as people experience complex life events surrounding health. In an earlier nursing study that linked the concepts of hope, enduring, and suffering into a single theoretical scheme, a state best described as 'uncertainty' arose. This study was undertaken to explore how this conceptualization fit with the scientific literature on uncertainty and to refine the concept. Initially, a concept analysis using advanced methods described by Morse, Hupcey, Mitcham and colleagues was completed. The concept was determined to be partially mature. A theoretical definition was derived and techniques of concept refinement using the literature as data were applied. The refined concept was found to be congruent with the concept of uncertainty that had emerged in the model of hope, enduring and suffering. Further investigation is needed to explore the extent of probabilistic reasoning and the effects of confidence and control on feelings of uncertainty and certainty.

  18. The effects of analogy-based instruction on concept learning and retention in a non-formal coral reef ecology program

    Science.gov (United States)

    Brylske, Alexander Frederick

    While a number of instructional models focus on the use of analogies, research into their effectiveness in enhancing comprehension and retention of scientific concepts, particularly involving adult learners, has been limited. The purpose of this study was to determine the efficacy of using the common teaching strategy for comparing the function of a coral reef to that of a city by using an analogy-based instructional model termed FAR. The training program entitled "Marine Resource Management for Dive Professionals" (MRMDP) was developed for this study. It was targeted to professionals in the recreational scuba industry to improve their understanding of coal reef ecology, as well as orient them to pertinent marine resource management issues, and promote environmentally-responsible attitudes and diving practices among their clients. A quasi-experimental pre-post-delayed posttest control group design was used to explore five research questions and corresponding hypotheses. A 55-item researcher-developed test of coral reef ecology was administered pre and post instruction. The delayed posttest was self-administered by the subjects three weeks after course completion. Data on seven experiential variables hypothesized as research factors were collected. Ten MRMPD courses were taught in seven nations, involving 194 subjects (85 subjects in four control courses, 109 in six treatment course). The results were analyzed using multiple regression/correlation (MRC) techniques to determine: (1) any significant relationship between pretest performance and experiential variables, (2) treatment versus control group posttest performance, and (3) treatment versus control group delayed posttest performance. Within the treatment group, learning gains and retention were determined by t-test analysis. Results indicated: (1) all research factors except one were significant predictors of pretest scores in the presence of the covariate; (2) no significant difference was found between

  19. Digital Maturity of the Firm's Business Model

    DEFF Research Database (Denmark)

    Groskovs, Sergejs; Vemula, Sreekanth

    We propose a digital maturity assessment model as an instrument for researchers and a strategic tool for managers. Existing literature lacks a conceptually clear way to measure the construct of digital maturity at the level of the firms business model. Our proposed instrument thus opens avenues f...

  20. A maturity model for industrial supply chains

    NARCIS (Netherlands)

    Hameri, A.P.; McKay, K.N.; Wiers, V.C.S.

    2013-01-01

    This article takes an evolutionary view of supply chains to suggest a series of distinct, contextual phases for supply chain execution and what maturity might mean at each phase. For example, what is best practice in a mature industry might not be best practice in a pioneering situation.Three

  1. 7 CFR 1421.101 - Maturity dates.

    Science.gov (United States)

    2010-01-01

    ... filed and disbursed except, for transferred marketing assistance loan collateral. The maturity date for transferred marketing assistance loan collateral will be the maturity date applicable to the original loan... AGRICULTURE LOANS, PURCHASES, AND OTHER OPERATIONS GRAINS AND SIMILARLY HANDLED COMMODITIES-MARKETING...

  2. Cone and Seed Maturation of Southern Pines

    Science.gov (United States)

    James P. Barnett

    1976-01-01

    If slightly reduced yields and viability are acceptable, loblolly and slash cone collections can begin 2 to 3 weeks before maturity if the cones are stored before processing. Longleaf(P. palestris Mill.) pine cones should be collected only when mature, as storage decreased germination of seeds from immature cones. Biochemical analyses to determine reducing sugar...

  3. POSTTREATMENT NEUROBLASTOMA MATURATION TO GANGLIONIC CELL TUMOR

    Directory of Open Access Journals (Sweden)

    M. V. Ryzhova

    2012-01-01

    Full Text Available Tumor cells can differentiate into more mature forms in undifferentiated or poorly differentiated tumors, such as medulloblastomas with increased nodularity, as well as neuroblastomas. The authors describe 2 cases of neuroblastoma maturation into ganglioneuroblastoma 5 months after chemotherapy in a 2-year-old girl and 3 years after radiotherapy in a 16-year-old girl.

  4. Assessing the Harvest Maturity of Brazilian Mangoes

    NARCIS (Netherlands)

    Pereira, T.; Tijskens, L.M.M.; Vanoli, M.; Rizzolo, A.; Eccher Zerbini, P.C.; Torricelli, A.; Filgueiras, H.; Spinelli, L.

    2010-01-01

    No clear criterion exists to determine the optimum time to harvest mango. Some empirical relations are used to assess maturity, such as shoulder development. Moreover, as a result of the typical growing conditions in tropical climates, a huge variation in maturity and ripeness exists, seriously

  5. Decision-Making Style and Vocational Maturity.

    Science.gov (United States)

    Phillips, Susan D.; Strohmer, Douglas C.

    1982-01-01

    Examined the relationship between decision-making style, scholastic achievement, and vocational maturity for college students (N=64). Results did not support the hypothesized relationship between rationality and attitudinal and cognitive maturity. Scholastic achievement and lack of dependent decision style were found to be moderately predictive of…

  6. Correlation of Improved Version of Cervical Vertebral Maturation Indicator with Other Growth Maturity Indicators

    Directory of Open Access Journals (Sweden)

    Tripti Tikku

    2013-01-01

    Conclusion: The correlation between middle phalanx of 3rd finger (MP3 and cervical vertebral maturation method (CVMI and CVMS was higher as compared to the correlation of either of the cervical vertebral maturation method or MP3 with dental maturation indicator.

  7. Assessing healthcare process maturity: challenges of using a business process maturity model

    NARCIS (Netherlands)

    Tarhan, A.; Turetken, O.; van den Biggelaar, F.J.H.M.

    2015-01-01

    Doi: 10.4108/icst.pervasivehealth.2015.259105 The quality of healthcare services is influenced by the maturity of healthcare processes used to develop it. A maturity model is an instrument to assess and continually improve organizational processes. In the last decade, a number of maturity models

  8. Reliability of cervical vertebral maturation staging.

    Science.gov (United States)

    Rainey, Billie-Jean; Burnside, Girvan; Harrison, Jayne E

    2016-07-01

    Growth and its prediction are important for the success of many orthodontic treatments. The aim of this study was to determine the reliability of the cervical vertebral maturation (CVM) method for the assessment of mandibular growth. A group of 20 orthodontic clinicians, inexperienced in CVM staging, was trained to use the improved version of the CVM method for the assessment of mandibular growth with a teaching program. They independently assessed 72 consecutive lateral cephalograms, taken at Liverpool University Dental Hospital, on 2 occasions. The cephalograms were presented in 2 different random orders and interspersed with 11 additional images for standardization. The intraobserver and interobserver agreement values were evaluated using the weighted kappa statistic. The intraobserver and interobserver agreement values were substantial (weighted kappa, 0.6-0.8). The overall intraobserver agreement was 0.70 (SE, 0.01), with average agreement of 89%. The interobserver agreement values were 0.68 (SE, 0.03) for phase 1 and 0.66 (SE, 0.03) for phase 2, with average interobserver agreement of 88%. The intraobserver and interobserver agreement values of classifying the vertebral stages with the CVM method were substantial. These findings demonstrate that this method of CVM classification is reproducible and reliable. Copyright © 2016 American Association of Orthodontists. Published by Elsevier Inc. All rights reserved.

  9. Set-Theoretic Approach to Maturity Models

    DEFF Research Database (Denmark)

    Lasrado, Lester Allan

    Despite being widely accepted and applied, maturity models in Information Systems (IS) have been criticized for the lack of theoretical grounding, methodological rigor, empirical validations, and ignorance of multiple and non-linear paths to maturity. This PhD thesis focuses on addressing...... these criticisms by incorporating recent developments in configuration theory, in particular application of set-theoretic approaches. The aim is to show the potential of employing a set-theoretic approach for maturity model research and empirically demonstrating equifinal paths to maturity. Specifically...... methodological guidelines consisting of detailed procedures to systematically apply set theoretic approaches for maturity model research and provides demonstrations of it application on three datasets. The thesis is a collection of six research papers that are written in a sequential manner. The first paper...

  10. Glucocorticoid programming of intrauterine development.

    Science.gov (United States)

    Fowden, A L; Valenzuela, O A; Vaughan, O R; Jellyman, J K; Forhead, A J

    2016-07-01

    Glucocorticoids (GCs) are important environmental and maturational signals during intrauterine development. Toward term, the maturational rise in fetal glucocorticoid receptor concentrations decreases fetal growth and induces differentiation of key tissues essential for neonatal survival. When cortisol levels rise earlier in gestation as a result of suboptimal conditions for fetal growth, the switch from tissue accretion to differentiation is initiated prematurely, which alters the phenotype that develops from the genotype inherited at conception. Although this improves the chances of survival should delivery occur, it also has functional consequences for the offspring long after birth. Glucocorticoids are, therefore, also programming signals that permanently alter tissue structure and function during intrauterine development to optimize offspring fitness. However, if the postnatal environmental conditions differ from those signaled in utero, the phenotypical outcome of early-life glucocorticoid receptor overexposure may become maladaptive and lead to physiological dysfunction in the adult. This review focuses on the role of GCs in developmental programming, primarily in farm species. It examines the factors influencing GC bioavailability in utero and the effects that GCs have on the development of fetal tissues and organ systems, both at term and earlier in gestation. It also discusses the windows of susceptibility to GC overexposure in early life together with the molecular mechanisms and long-term consequences of GC programming with particular emphasis on the cardiovascular, metabolic, and endocrine phenotype of the offspring. Copyright © 2016 Elsevier Inc. All rights reserved.

  11. STRATEGIC MAPS AND CRITICAL FACTORS FOR PROJECT MANAGEMENT MATURITY: A PROPOSAL

    Directory of Open Access Journals (Sweden)

    Sady Darcy Silva Junior

    2010-06-01

    Full Text Available Project Management (PM and Strategic Management (SM are two subjects of growing importance in the corporate environment which are normally considered in isolation. One way of integrating these two concepts might be via the concept of project management maturity (Westphal et al., 2008. Rabechini and Pessoa (2005 state that to obtain project management maturity, it is necessary to achieve success in a number of critical factors which include organizational culture and structure, as well as sponsorship at both tactical and strategic levels (Silva et al., 2008. Another way of achieving this connection is by using Balanced Scorecard (BSC as an auxiliary tool to integrate between projects and organizational strategy (Brock et al., 2003. The original developers of the BSC, Kaplan e Norton, subsequently developed the concept of strategy mapping, which they affirm "represents the missing link between the formulation and the execution of the strategy" (Kaplan e Norton, 2004. This paper proposes a strategy map identifying critical factors for attaining project management maturity. To formulate the map, we used a qualitative, exploratory approach oriented by Project Management theory and strategy mapping. We first identified 13 critical factors, then developed a strategy map, which was evaluated by six specialists (three in SM area and three in PM area.The results suggest links between strategic mapping nad critical factors in project management. It also contributes to both areas independently. Specifically, the study identifies critical factors for project management maturity while demonstrating the applicability of strategic mapping techniques to Balanced Scorecard concepts.

  12. Against dichotomies: on mature care and self-sacrifice in care ethics

    NARCIS (Netherlands)

    Nistelrooij, A.A.M. van; Leget, C.J.W.

    2016-01-01

    Introduction: In previous issues of this journal Carol Gilligan’s original concept of mature care has been conceptualized by several (especially Norwegian) contributors. This has resulted in a dichotomous view of self and other, and of self-care and altruism, in which any form of self-sacrifice is

  13. ENHANCING LEAN SUPPLY CHAIN MATURITY WITH BUSINESS PROCESS MANAGEMENT

    Directory of Open Access Journals (Sweden)

    Jurij Jaklic

    2006-12-01

    Full Text Available In today’s global market the main focus of competition is not only between different companies but also between supply chains. Technological changes and organizational improvements are important for effective supply chain management (SCM, however, the main cause of SCM improvements is not the implementation of an information system (IS itself, but rather a change and an integration of business processes. The paper summarizes the most important concepts of SCM and specifically concentrates on the importance of business process management (BPM in supply chains, because full advantages can be realized when business processes in the supply chain are well defined, integrated and managed. The main purpose of this paper is to show that successful SCM calls for the maturity of supply chain processes in all involved companies and at the supply chain level, which can be realized by using effective BPM methods. A necessary condition for growing of SCM in terms of supply chain process maturity levels is an inter-organizational information system development and process renovation. Yet, BPM should not be considered as a one-time project of IS implementation and process change, but as a permanent process performance measurement, analysis and continuous improvement of the supply chain processes. The concepts are illustrated with a case study of fuel supply process.

  14. Basic concepts

    International Nuclear Information System (INIS)

    Dorner, B.

    1999-01-01

    The basic concepts of neutron scattering as a tool for studying the structure and the dynamics of condensed matter. Theoretical aspects are outlined, the two different cases of coherent and incoherent scattering are presented. The issue of resolution, coherence volume and the role of monochromators are also discussed. (K.A.)

  15. Simple Concepts

    Czech Academy of Sciences Publication Activity Database

    Materna, Pavel

    2013-01-01

    Roč. 28, č. 3 (2013), s. 295-319 ISSN 0353-5150 R&D Projects: GA ČR(CZ) GAP401/10/0792 Institutional support: RVO:67985955 Keywords : concept * constructions * set-theoretical paradigm Subject RIV: AA - Philosophy ; Religion

  16. Nursing care plans versus concept maps in the enhancement of critical thinking skills in nursing students enrolled in a baccalaureate nursing program.

    Science.gov (United States)

    Sinatra-Wilhelm, Tina

    2012-01-01

    Appropriate and effective critical thinking and problem solving is necessary for all nurses in order to make complex decisions that improve patient outcomes, safety, and quality of nursing care. With the current emphasis on quality improvement, critical thinking ability is a noteworthy concern within the nursing profession. An in-depth review of literature related to critical thinking was performed. The use of nursing care plans and concept mapping to improve critical thinking skills was among the recommendations identified. This study compares the use of nursing care plans and concept mapping as a teaching strategy for the enhancement of critical thinking skills in baccalaureate level nursing students. The California Critical Thinking Skills Test was used as a method of comparison and evaluation. Results indicate that concept mapping enhances critical thinking skills in baccalaureate nursing students.

  17. Game Maturity Model for Health Care.

    Science.gov (United States)

    de Boer, Jan C; Adriani, Paul; van Houwelingen, Jan Willem; Geerts, A

    2016-04-01

    This article introduces the Game Maturity Model for the healthcare industry as an extension to the general Game Maturity Model and describes the usage by two case studies of applied health games. The Game Maturity Model for healthcare provides a practical and value-adding method to assess existing games and to determine strategic considerations for application of applied health games. Our forecast is that within 5 years the use and development of applied games will have a role in our daily lives and the way we organize health care that will be similar to the role social media has today.

  18. Service Quality and Process Maturity Assessment

    Directory of Open Access Journals (Sweden)

    Serek Radomir

    2013-12-01

    Full Text Available This article deals with service quality and the methods for its measurement and improvements to reach the so called service excellence. Besides older methods such as SERVQUAL and SERPERF, there are also shortly described capability maturity models based on which the own methodology is developed and used for process maturity assessment in organizations providing technical services. This method is equally described and accompanied by examples on pictures. The verification of method functionality is explored on finding a correlation between service employee satisfaction and average process maturity in a service organization. The results seem to be quite promising and open an arena for further studies.

  19. Maturity grids as tools for change management

    DEFF Research Database (Denmark)

    Maier, Anja; Moultrie, James; Clarkson, P John

    2011-01-01

    A maturity grid is a change management tool. Levels of maturity are assigned against aspects of an area under study, thus creating a grid. Text descriptions at the resulting intersections describe the typical behaviour exhibited by a firm for each area under study and from the basis...... for the assessment scale. It is a flexible assessment technique that is used by practitioners in industry, consultants and researchers in academia for diagnostic, reflective and improvement purposes. A large number of maturity grids have been proposed to assess a range of capabilities including quality management...

  20. Promoção do autoconceito e auto estima através de um programa de leitura a par Promoting self-concept and self esteem through a peer reading program

    Directory of Open Access Journals (Sweden)

    Vera Monteiro

    2012-01-01

    Full Text Available Um autoconceito positivo é fundamental para o sucesso académico das crianças. Uma forma de promover o autoconceito é implementando programas tutoriais. Deste modo, esta investigação teve como objectivo implementar e avaliar os efeitos de um Programa de Leitura a Par, no autoconceito de alunos dos 2º e 4º anos de escolaridade e na auto-estima dos alunos mais velhos. Para avaliar as autopercepções utilizaram-se duas escalas devido à discrepância de idade das crianças. Os resultados obtidos demonstram que este Programa teve um efeito positivo em todas as dimensões do autoconceito, quer para os tutores como para os tutorandos, e na auto-estima dos tutores. As crianças do Grupo Experimental apresentaram valores estatisticamente superiores aos dos alunos do Grupo de Controle.A positive self-concept is essential for children's academic success. One way of promoting self-concept is by the implementation of tutorial programs. Thus, this research aimed to evaluate the effects of a Peer Reading Program on self-concept of 2nd and 4th grade students and on self-esteem of older students. In order to assess self-perceptions two scales were used due to the discrepancy in children's age. The results show that the Peer Reading Program had a positive effect on all dimensions of self-concept, for tutors and tutees, and on tutors' self-esteem. Children's outcomes obtained in the experimental group were statistically higher than those of students in the control group.

  1. Nuclear electric propulsion for planetary science missions: NASA technology program planning

    International Nuclear Information System (INIS)

    Doherty, M.P.

    1993-01-01

    This paper presents the status of technology program planning to achieve readiness of Nuclear Electric Propulsion technologies needed to meet the advanced propulsion system requirements for planetary science missions in the next century. The technology program planning is based upon technologies of significant maturity: ion electric propulsion and the SP-100 space nulcear power technologies. Detailed plans are presented herein for the required ion electric propulsion technology development and demonstration. Closer coordination between space nuclear power and space electric propulsion technology programs is a necessity as technology plans are being further refined in light of NEP concept definition and possible early NEP flight activities

  2. Practical C++ programming

    National Research Council Canada - National Science Library

    Oualline, Steve

    2003-01-01

    ... . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 3 4 6 3 2. The Basics of Program Writing Programs from Conception to Execution Creating a Real Program Getting Help in Unix Getting Help in an IDE Programming...

  3. ITER concept definition. V.2

    International Nuclear Information System (INIS)

    1989-01-01

    Volume II of the two volumes describing the concept definition of the International Thermonuclear Experimental Reactor deals with the ITER concept in technical depth, and covers all areas of design of the ITER tokamak. Included are an assessment of the current database for design, scoping studies, rationale for concepts selection, performance flexibility, the ITER concept, the operations and experimental/testing program, ITER parameters and design phase schedule, and research and development specific to ITER. This latter includes a definition of specific research and development tasks, a division of tasks among members, specific milestones, required results, and schedules. Figs and tabs

  4. 7 CFR 1710.115 - Final maturity.

    Science.gov (United States)

    2010-01-01

    ... Basic Policies § 1710.115 Final maturity. (a) RUS is authorized to make loans and loan guarantees with a... due, in part, to obsolescence. Operating loans to finance working capital required for the initial...

  5. Geospatial Information System Capability Maturity Models

    Science.gov (United States)

    2017-06-01

    To explore how State departments of transportation (DOTs) evaluate geospatial tool applications and services within their own agencies, particularly their experiences using capability maturity models (CMMs) such as the Urban and Regional Information ...

  6. Pristipomoides filamentosus Size at Maturity Study

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This data set contains information used to help determine median size at 50% maturity for the bottomfish species, Pristipomoides filamentosus in the Main Hawaiian...

  7. Astrophysical Concepts

    CERN Document Server

    Harwit, Martin

    2006-01-01

    This classic text, aimed at senior undergraduates and beginning graduate students in physics and astronomy, presents a wide range of astrophysical concepts in sufficient depth to give the reader a quantitative understanding of the subject. Emphasizing physical concepts, the book outlines cosmic events but does not portray them in detail: it provides a series of astrophysical sketches. For this fourth edition, nearly every part of the text has been reconsidered and rewritten, new sections have been added to cover recent developments, and others have been extensively revised and brought up to date. The book begins with an outline of the scope of modern astrophysics and enumerates some of the outstanding problems faced in the field today. The basic physics needed to tackle these questions are developed in the next few chapters using specific astronomical processes as examples. The second half of the book enlarges on these topics and shows how we can obtain quantitative insight into the structure and evolution of...

  8. Concept caring in nursing

    Directory of Open Access Journals (Sweden)

    Lenka Drahošová

    2016-05-01

    Full Text Available Aim: The aim of this literature review was to search for qualitative studies focusing on the concept of caring in nursing, to analyse them and to synthesize knowledge that concerns the definition of the concept of caring in nursing from the point of view of nurses and patients. Design: Review. Methods: Qualitative studies were searched for systematically in the electronic databases Academic Search Complete (EBSCO, CINAHL, Medline, Science Direct, and the Wiley Library Online, according to set criteria and defined key words for the period 1970-2015. Seven selected articles were analysed after selection of documents with the aid of a sorting chart. Results: Nurses understand caring in nursing as a relationship with patients which is characterised on the nurses' part by an individual and empathetic approach, attentiveness, experience and sensitivity. Through caring, active communication takes place, providing information which reduces anxiety and leads to the breaking down of barriers. This relationship helps protect patients' autonomy, dignity and comfort. It requires experience on the part of nurses, and it is influenced by the environment. The nurses' personal qualities (what professional knowledge, attitudes and skills they have and their availability, reliability, and emotional and physical support are important to patients. Conclusion: The concept of caring is a content specific interpersonal process which is characterized by the professional knowledge, skills, personal maturity, and interpersonal sensitivity of nurses, which result in the protection, emotional support, and the meeting of bio-psycho-social needs of patients. The results of the overview study could contribute to an explanation and understanding of the nature of caring as a fundamental feature of the discipline of nursing.

  9. Advanced Messaging Concept Development Basic Safety Message

    Data.gov (United States)

    Department of Transportation — Contains all Basic Safety Messages (BSMs) collected during the Advanced Messaging Concept Development (AMCD) field testing program. For this project, all of the Part...

  10. Introductory concepts

    International Nuclear Information System (INIS)

    Barnes, W.E.

    1983-01-01

    Physical theories are commonly classified as being either ''classical'' or ''modern''. The reasons for this distinction are both historical and substantive. Limited in the sophistication of their measuring instruments, early scientists proposed theories appropriate for the description of the simplest and most accessible physical phenomena, e.g., the trajectories of the planets. Because of the class of phenomena observed, certain beliefs came to underlie all classical theories with regard to the nature of time, space, matter, etc. For example, the idea was undisputed that an object has at all times both a definite position and velocity. Not until the interior of the atom and the nature of electromagnetic radiation were explored was it discovered that the concepts of classical physics are inadequate to deal with many phenomena. A reassessment of fundamental postulates led to the formulation of modern physics which, it is believed, successfully treats the behavior of all physical systems. To gain an understanding of the rudiments of modern physics, one proceeds as the early scientists did by first mastering the classical concepts that emerge from their intuitive picture of the world. Modifications of these concepts are subsequently introduced which allow a more accurate treatment of physical phenomena, particularly atomic and nuclear systems

  11. Mature teratoma of the posterior mediastinum

    Energy Technology Data Exchange (ETDEWEB)

    Kurosaki, Y.; Tanaka, Y.O.; Itai, Y. [Department of Radiology, Institute of Clinical Medicine, University of Tsukuba, Tsukuba-shi, Ibaraki-ken 305 (Japan)

    1998-02-01

    The vast majority of germ cell tumors in the thorax arise at or near the thymus. We report a case of a 41-year-old man with mature teratoma of the posterior mediastinum. He was asymptomatic and was incidentally found to have a posterior mediastinal mass. Computed tomography was helpful in suggesting a diagnosis of mature teratoma by demonstrating the presence of fat and calcification. The differential diagnosis included neurogenic tumors, liposarcoma, and extramedullary hematopoiesis. (orig.) With 2 figs., 18 refs.

  12. Mature teratoma of the posterior mediastinum

    International Nuclear Information System (INIS)

    Kurosaki, Y.; Tanaka, Y.O.; Itai, Y.

    1998-01-01

    The vast majority of germ cell tumors in the thorax arise at or near the thymus. We report a case of a 41-year-old man with mature teratoma of the posterior mediastinum. He was asymptomatic and was incidentally found to have a posterior mediastinal mass. Computed tomography was helpful in suggesting a diagnosis of mature teratoma by demonstrating the presence of fat and calcification. The differential diagnosis included neurogenic tumors, liposarcoma, and extramedullary hematopoiesis. (orig.)

  13. Radiation induced early maturing mutants in barley

    International Nuclear Information System (INIS)

    Kumar, R.; Chauhan, S.V.S.; Sharma, R.P.

    1978-01-01

    In M 2 generation, two early maturing plants were screened from a single spike progeny of a plant obtained from 20 kR of gamma-ray irradiation of a six-rowed barley (Hordeum vulgare L. var. Jyoti). Their true breeding nature was confirmed in M 3 generation. These mutants flower and mature 38 and 22 days earlier than those of control. (auth.)

  14. Teaching GUI-Programming Concepts to Prospective K12 ICT Teachers: MIT App Inventor as an Alternative to Text-Based Languages

    Science.gov (United States)

    Mihci, Can; Ozdener Donmez, Nesrin

    2017-01-01

    The purpose of this research is to investigate the short and long-term effects of using GUI-oriented visual Blocks-Based Programming languages (BBL) as a 2nd tier tool when teaching programming to prospective K12 ICT teachers. In a mixed-method approach, the effect on academic success as well as the impact on professional opinions and preferences…

  15. Generic repository design concepts and thermal analysis (FY11)

    International Nuclear Information System (INIS)

    Howard, Robert; Dupont, Mark; Blink, James A.; Fratoni, Massimiliano; Greenberg, Harris; Carter, Joe; Hardin, Ernest L.; Sutton, Mark A.

    2011-01-01

    Reference concepts for geologic disposal of used nuclear fuel and high-level radioactive waste in the U.S. are developed, including geologic settings and engineered barriers. Repository thermal analysis is demonstrated for a range of waste types from projected future, advanced nuclear fuel cycles. The results show significant differences among geologic media considered (clay/shale, crystalline rock, salt), and also that waste package size and waste loading must be limited to meet targeted maximum temperature values. In this study, the UFD R and D Campaign has developed a set of reference geologic disposal concepts for a range of waste types that could potentially be generated in advanced nuclear FCs. A disposal concept consists of three components: waste inventory, geologic setting, and concept of operations. Mature repository concepts have been developed in other countries for disposal of spent LWR fuel and HLW from reprocessing UNF, and these serve as starting points for developing this set. Additional design details and EBS concepts will be considered as the reference disposal concepts evolve. The waste inventory considered in this study includes: (1) direct disposal of SNF from the LWR fleet, including Gen III+ advanced LWRs being developed through the Nuclear Power 2010 Program, operating in a once-through cycle; (2) waste generated from reprocessing of LWR UOX UNF to recover U and Pu, and subsequent direct disposal of used Pu-MOX fuel (also used in LWRs) in a modified-open cycle; and (3) waste generated by continuous recycling of metal fuel from fast reactors operating in a TRU burner configuration, with additional TRU material input supplied from reprocessing of LWR UOX fuel. The geologic setting provides the natural barriers, and establishes the boundary conditions for performance of engineered barriers. The composition and physical properties of the host medium dictate design and construction approaches, and determine hydrologic and thermal responses of

  16. Generic repository design concepts and thermal analysis (FY11).

    Energy Technology Data Exchange (ETDEWEB)

    Howard, Robert (Oak Ridge National Laboratory, Oak Ridge, TN); Dupont, Mark (Savannah River Nuclear Solutions, Aiken, SC); Blink, James A. (Lawrence Livermore National Laboratory, Livermore, CA); Fratoni, Massimiliano (Lawrence Livermore National Laboratory, Livermore, CA); Greenberg, Harris (Lawrence Livermore National Laboratory, Livermore, CA); Carter, Joe (Savannah River Nuclear Solutions, Aiken, SC); Hardin, Ernest L.; Sutton, Mark A. (Lawrence Livermore National Laboratory, Livermore, CA)

    2011-08-01

    Reference concepts for geologic disposal of used nuclear fuel and high-level radioactive waste in the U.S. are developed, including geologic settings and engineered barriers. Repository thermal analysis is demonstrated for a range of waste types from projected future, advanced nuclear fuel cycles. The results show significant differences among geologic media considered (clay/shale, crystalline rock, salt), and also that waste package size and waste loading must be limited to meet targeted maximum temperature values. In this study, the UFD R&D Campaign has developed a set of reference geologic disposal concepts for a range of waste types that could potentially be generated in advanced nuclear FCs. A disposal concept consists of three components: waste inventory, geologic setting, and concept of operations. Mature repository concepts have been developed in other countries for disposal of spent LWR fuel and HLW from reprocessing UNF, and these serve as starting points for developing this set. Additional design details and EBS concepts will be considered as the reference disposal concepts evolve. The waste inventory considered in this study includes: (1) direct disposal of SNF from the LWR fleet, including Gen III+ advanced LWRs being developed through the Nuclear Power 2010 Program, operating in a once-through cycle; (2) waste generated from reprocessing of LWR UOX UNF to recover U and Pu, and subsequent direct disposal of used Pu-MOX fuel (also used in LWRs) in a modified-open cycle; and (3) waste generated by continuous recycling of metal fuel from fast reactors operating in a TRU burner configuration, with additional TRU material input supplied from reprocessing of LWR UOX fuel. The geologic setting provides the natural barriers, and establishes the boundary conditions for performance of engineered barriers. The composition and physical properties of the host medium dictate design and construction approaches, and determine hydrologic and thermal responses of the

  17. Intra-follicular interactions affecting mammalian oocyte maturation

    NARCIS (Netherlands)

    van Tol, H.T.A.|info:eu-repo/dai/nl/313871817

    2009-01-01

    Nuclear oocyte maturation is defined as reinitiation and progression of the first meiotic division and subsequently formation of the methaphase II (MII) plate. Concomitantly with nuclear maturation, cytoplasmic maturation which is essential for proper fertilization and early embryo development is

  18. Mature students' perspectives of studying radiography

    International Nuclear Information System (INIS)

    Williams, M.; Decker, S.

    2009-01-01

    The study set out to explore the experiences of all final year mature students on a diagnostic radiography course, in one United Kingdom University. The aims were to identify any difficulties they may have had and to make recommendations to improve mature students' learning experiences with the hope of lowering attrition rates in this group. A qualitative study involving one-to-one audio recorded interviews was utilised. Analysis of the transcripts of interviews suggested that the group believed that their maturity and previous experiences helped them in the clinical environment and put them in a good position, when asked, to counsel younger students. However for some of the mature students these experiential skills did not extend fully into seeking appropriate support for themselves. The mature students were found to be highly motivated but there was a conflict between balancing clinical and academic aspects of studying as well as balancing studying with home life. The group was found to be unprepared for the volume of academic work and its detrimental effect on family life as they sacrificed other aspects of their lives in order to complete the course. It is recommended that forewarning and forearming prospective mature students be considered by radiography education providers. Setting up and utilising an on-line forum providing a 24/7 peer support environment would aid in coping with academic, clinical or personal problems

  19. Color back projection for fruit maturity evaluation

    Science.gov (United States)

    Zhang, Dong; Lee, Dah-Jye; Desai, Alok

    2013-12-01

    In general, fruits and vegetables such as tomatoes and dates are harvested before they fully ripen. After harvesting, they continue to ripen and their color changes. Color is a good indicator of fruit maturity. For example, tomatoes change color from dark green to light green and then pink, light red, and dark red. Assessing tomato maturity helps maximize its shelf life. Color is used to determine the length of time the tomatoes can be transported. Medjool dates change color from green to yellow, and the orange, light red and dark red. Assessing date maturity helps determine the length of drying process to help ripen the dates. Color evaluation is an important step in the processing and inventory control of fruits and vegetables that directly affects profitability. This paper presents an efficient color back projection and image processing technique that is designed specifically for real-time maturity evaluation of fruits. This color processing method requires very simple training procedure to obtain the frequencies of colors that appear in each maturity stage. This color statistics is used to back project colors to predefined color indexes. Fruit maturity is then evaluated by analyzing the reprojected color indexes. This method has been implemented and used for commercial production.

  20. Evolution of a minimal parallel programming model

    International Nuclear Information System (INIS)

    Lusk, Ewing; Butler, Ralph; Pieper, Steven C.

    2017-01-01

    Here, we take a historical approach to our presentation of self-scheduled task parallelism, a programming model with its origins in early irregular and nondeterministic computations encountered in automated theorem proving and logic programming. We show how an extremely simple task model has evolved into a system, asynchronous dynamic load balancing (ADLB), and a scalable implementation capable of supporting sophisticated applications on today’s (and tomorrow’s) largest supercomputers; and we illustrate the use of ADLB with a Green’s function Monte Carlo application, a modern, mature nuclear physics code in production use. Our lesson is that by surrendering a certain amount of generality and thus applicability, a minimal programming model (in terms of its basic concepts and the size of its application programmer interface) can achieve extreme scalability without introducing complexity.

  1. Assessment of cortical maturation with prenatal MRI. Part I: normal cortical maturation

    International Nuclear Information System (INIS)

    Fogliarini, Celine; Chaumoitre, Katia; Chapon, Frederique; Levrier, Olivier; Girard, Nadine; Fernandez, Carla; Figarella-Branger, Dominique

    2005-01-01

    Cortical maturation, especially gyral formation, follows a temporospatial schedule and is a good marker of fetal maturation. Although ultrasonography is still the imaging method of choice to evaluate fetal anatomy, MRI has an increasingly important role in the detection of brain abnormalities, especially of cortical development. Knowledge of MRI techniques in utero with the advantages and disadvantages of some sequences is necessary, in order to try to optimize the different magnetic resonance sequences to be able to make an early diagnosis. The different steps of cortical maturation known from histology represent the background necessary for the understanding of maturation in order to be then able to evaluate brain maturation through neuroimaging. Illustrations of the normal cortical maturation are given for each step accessible to MRI for both the cerebral hemispheres and the posterior fossa. (orig.)

  2. Assessment of cortical maturation with prenatal MRI. Part I: normal cortical maturation

    Energy Technology Data Exchange (ETDEWEB)

    Fogliarini, Celine [Faculte Timone, Centre de Resonance Magnetique Biologique et Medicale, Marseille (France); Chaumoitre, Katia [Hopital Nord, Department of Radiology, Marseille (France); Chapon, Frederique; Levrier, Olivier; Girard, Nadine [Hopital Timone, Department of Neuroradiology, Marseille Cedex 5 (France); Fernandez, Carla; Figarella-Branger, Dominique [Hopital Timone, Department of Pathology, Marseille (France)

    2005-08-01

    Cortical maturation, especially gyral formation, follows a temporospatial schedule and is a good marker of fetal maturation. Although ultrasonography is still the imaging method of choice to evaluate fetal anatomy, MRI has an increasingly important role in the detection of brain abnormalities, especially of cortical development. Knowledge of MRI techniques in utero with the advantages and disadvantages of some sequences is necessary, in order to try to optimize the different magnetic resonance sequences to be able to make an early diagnosis. The different steps of cortical maturation known from histology represent the background necessary for the understanding of maturation in order to be then able to evaluate brain maturation through neuroimaging. Illustrations of the normal cortical maturation are given for each step accessible to MRI for both the cerebral hemispheres and the posterior fossa. (orig.)

  3. The role of psychological maturity in direct and indirect aggressiveness in Spanish adolescents.

    Science.gov (United States)

    Morales-Vives, Fabia; Camps, Elisa; Lorenzo-Seva, Urbano; Vigil-Colet, Andreu

    2014-01-01

    Understanding which factors are related to different kinds of aggressive behaviors in adolescents might help to improve violence-prevention programs for schools and families. Although some studies show that adolescents who are less psychologically mature tend to display more behavioral problems, few studies have been performed on the relationship between aggressive behavior and psychological maturity in adolescence, and no studies have focused specifically on indirect aggression. For this reason, the current research tests the role of psychological maturity in direct and indirect aggressiveness in a sample of 193 Spanish adolescents (49% boys and 51% girls) between 14 and 18 years old (M = 16.1, SD = 1.18). The results show that psychological maturity is related to both kinds of aggressiveness. In fact, less mature adolescents tend to show higher levels of direct aggression (r = -.22, p self-reliance and identity: self-reliance is the main predictor of indirect aggression (p < .01) and identity is the main predictor of direct aggression (p < .01). Moreover, overall psychological maturity is more related to indirect aggression in men than in women (p < .05), so the increase in psychological maturity implies a greater decrease of indirect aggression in men.

  4. Ethical considerations in investigating youth alcohol norms and behaviours: a case for mature minor consent.

    Science.gov (United States)

    Hildebrand, J; Maycock, B; Comfort, J; Burns, S; Adams, E; Howat, P

    2015-12-01

    Mature minor consent only became available in Australia in 2007. There is neither an explicitly defined protocol, nor a clear definition evident in the literature relating to use of the mature minor concept in health research. Due to difficulties in defining fixed age ranges to varying levels of maturity and vulnerability, there is a lack of clarity surrounding when it might be reasonable and ethical to apply for or grant a waiver for parental consent. This paper describes the challenges faced and solutions created when gaining approval for use of mature minor consent in a respondent-driven sampling (RDS) study to explore the social norms and alcohol consumption among 14-17-year-old adolescents (n = 1012) in the community. The University's Human Research Ethics Committee granted mature minor consent for this study, and the techniques applied enabled recruitment of adolescents from community-based settings through use of RDS to achieve the required sample. This paper has relevance for research that requires a waiver for parental consent; it presents a case study for assessing mature minors and makes recommendations on how ethical guidelines can be improved to assist human research ethics application processes.

  5. The Iodine Satellite (iSAT) Hall Thruster Demonstration Mission Concept and Development

    Science.gov (United States)

    Dankanich, John W.; Polzin, Kurt A.; Calvert, Derek; Kamhawi, Hani

    2014-01-01

    The use of iodine propellant for Hall thrusters has been studied and proposed by multiple organizations due to the potential mission benefits over xenon. In 2013, NASA Marshall Space Flight Center competitively selected a project for the maturation of an iodine flight operational feed system through the Technology Investment Program. Multiple partnerships and collaborations have allowed the team to expand the scope to include additional mission concept development and risk reduction to support a flight system demonstration, the iodine Satellite (iSAT). The iSAT project was initiated and is progressing towards a technology demonstration mission preliminary design review. The current status of the mission concept development and risk reduction efforts in support of this project is presented.

  6. Concept mapping in a critical care orientation program: a pilot study to develop critical thinking and decision-making skills in novice nurses.

    Science.gov (United States)

    Wahl, Stacy E; Thompson, Anita M

    2013-10-01

    Newly graduated registered nurses who were hired into a critical care intensive care unit showed a lack of critical thinking skills to inform their clinical decision-making abilities. This study evaluated the effectiveness of concept mapping as a teaching tool to improve critical thinking and clinical decision-making skills in novice nurses. A self-evaluation tool was administered before and after the learning intervention. The 25-item tool measured five key indicators of the development of critical thinking skills: problem recognition, clinical decision-making, prioritization, clinical implementation, and reflection. Statistically significant improvements were seen in 10 items encompassing all five indicators. Concept maps are an effective tool for educators to use in assisting novice nurses to develop their critical thinking and clinical decision-making skills. Copyright 2013, SLACK Incorporated.

  7. ANALISIS TINGKAT KEMATANGAN (MATURITY LEVELS UNIT LAYANAN PENGADAAN KABUPATEN BADUNG

    Directory of Open Access Journals (Sweden)

    I Gde Uma Darmapramita

    2015-07-01

    Full Text Available The implementation of government procurement of goods and service is governed by presidential regulation number 70 year of 2012.  According to that, in Badung Regency implemented centralized in Procurement Service Unit of Badung Regency. As the one of Indonesia procurement unit pilot, Procurement Service Unit of Badung Regency has given the opportunity to perform a self assessment of its  maturity levels as government unit. The objective of this research is to find factors that influence Procuremet Service Unit of Badung Regency maturity levels, and also to find out in what level is Procurement Service Unit of Badung Regency stand. Data collection for this research have done by  using questionnaire that involve 50 respondents who understand very well about the duties and function of Procurement Service Unit of Badung Regency to perform a government procurement of good and services. The data analysis have been performed by use of factor analysis and supported by SPSS program. The result shows there are 3 factors that influent the Procurement Service Unit of Badung Regency maturity levels, which are : the synergy and organization culture, resources and risk management and organization’s performance development.  Whereas the maturity levels of Procurement Service Unit of Badung Regency is stand at compliance. Based to the factors that formed, the highly commitment and strong leadership of Badung Regency leader are very decisive to push ahead the enhancement  and  the development of Procurement Service Unit of Badung Regency.  First thing can be done is to establish an independent Procurement Service Unit therewith its Procurement Unit Development road maps that can be tiered and sustainable plan, monitor and evaluate

  8. Advancing Uncertainty: Untangling and Discerning Related Concepts

    Directory of Open Access Journals (Sweden)

    Janice Penrod

    2002-12-01

    Full Text Available Methods of advancing concepts within the qualitative paradigm have been developed and articulated. In this section, I describe methodological perspectives of a project designed to advance the concept of uncertainty using multiple qualitative methods. Through a series of earlier studies, the concept of uncertainty arose repeatedly in varied contexts, working its way into prominence, and warranting further investigation. Processes of advanced concept analysis were used to initiate the formal investigation into the meaning of the concept. Through concept analysis, the concept was deconstructed to identify conceptual components and gaps in understanding. Using this skeletal framework of the concept identified through concept analysis, subsequent studies were carried out to add ‘flesh’ to the concept. First, a concept refinement using the literature as data was completed. Findings revealed that the current state of the concept of uncertainty failed to incorporate what was known of the lived experience. Therefore, using interview techniques as the primary data source, a phenomenological study of uncertainty among caregivers was conducted. Incorporating the findings of the phenomenology, the skeletal framework of the concept was further fleshed out using techniques of concept correction to produce a more mature conceptualization of uncertainty. In this section, I describe the flow of this qualitative project investigating the concept of uncertainty, with special emphasis on a particular threat to validity (called conceptual tunnel vision that was identified and addressed during the phases of concept correction. Though in this article I employ a study of uncertainty for illustration, limited substantive findings regarding uncertainty are presented to retain a clear focus on the methodological issues.

  9. Professional confidence: a concept analysis.

    Science.gov (United States)

    Holland, Kathlyn; Middleton, Lyn; Uys, Leana

    2012-03-01

    Professional confidence is a concept that is frequently used and or implied in occupational therapy literature, but often without specifying its meaning. Rodgers's Model of Concept Analysis was used to analyse the term "professional confidence". Published research obtained from a federated search in four health sciences databases was used to inform the concept analysis. The definitions, attributes, antecedents, and consequences of professional confidence as evidenced in the literature are discussed. Surrogate terms and related concepts are identified, and a model case of the concept provided. Based on the analysis, professional confidence can be described as a dynamic, maturing personal belief held by a professional or student. This includes an understanding of and a belief in the role, scope of practice, and significance of the profession, and is based on their capacity to competently fulfil these expectations, fostered through a process of affirming experiences. Developing and fostering professional confidence should be nurtured and valued to the same extent as professional competence, as the former underpins the latter, and both are linked to professional identity.

  10. A Partnership Training Program in Breast Cancer Diagnosis: Concept Development of the Next Generation Diagnostic Breast Imaging Using Digital Image Library and Networking Techniques

    National Research Council Canada - National Science Library

    Chouikha, Mohamed F

    2004-01-01

    ...); and Georgetown University (Image Science and Information Systems, ISIS). In this partnership training program, we will train faculty and students in breast cancer imaging, digital image database library techniques and network communication strategy...

  11. MATURITY IN LOGISTICS PROJECT MANAGEMENT APPLIED TO AN AUTOMOTIVE INDUSTRY CEARENSE

    Directory of Open Access Journals (Sweden)

    Danilo Cavalcante de Vasconcelos

    2012-04-01

    Full Text Available The present study aims to develop the concepts applied by the PMBOK in efficient management of logistics projects and production management through a case study, seeking the best use of resources used in projects. Thus, we used the analysis of a real case study in a comparative way with the indicators of the model PMMM - Maturity Model Project Management Sector - proposed by Prado (2003, and applied to an automotive company. The findings point to a low level of maturity in project management, demonstrating the need for corrective action.

  12. Efficacy of a Community-Based Technology-Enabled Physical Activity Counseling Program for People With Knee Osteoarthritis: Proof-of-Concept Study.

    Science.gov (United States)

    Li, Linda C; Sayre, Eric C; Xie, Hui; Falck, Ryan S; Best, John R; Liu-Ambrose, Teresa; Grewal, Navi; Hoens, Alison M; Noonan, Greg; Feehan, Lynne M

    2018-04-30

    Current practice guidelines emphasize the use of physical activity as the first-line treatment of knee osteoarthritis; however, up to 90% of people with osteoarthritis are inactive. We aimed to assess the efficacy of a technology-enabled counseling intervention for improving physical activity in people with either a physician-confirmed diagnosis of knee osteoarthritis or having passed two validated criteria for early osteoarthritis. We conducted a proof-of-concept randomized controlled trial. The immediate group received a brief education session by a physical therapist, a Fitbit Flex, and four biweekly phone calls for activity counseling. The delayed group received the same intervention 2 months later. Participants were assessed at baseline (T0) and at the end of 2 months (T1), 4 months (T2), and 6 months (T3). Outcomes included (1) mean time on moderate-to-vigorous physical activity (MVPA ≥3 metabolic equivalents [METs], primary outcome), (2) mean time on MVPA ≥4 METs, (3) mean daily steps, (4) mean time on sedentary activities, (5) Knee Injury and Osteoarthritis Outcome Score (KOOS), and (6) Partners in Health scale. Mixed-effects repeated measures analysis of variance was used to assess five planned contrasts of changes in outcome measures over measurement periods. The five contrasts were (1) immediate T1-T0 vs delayed T1-T0, (2) delayed T2-T1 vs delayed T1-T0, (3) mean of contrast 1 and contrast 2, (4) immediate T1-T0 vs delayed T2-T1, and (5) mean of immediate T2-T1 and delayed T3-T2. The first three contrasts estimate the between-group effects. The latter two contrasts estimate the effect of the 2-month intervention delay on outcomes. We recruited 61 participants (immediate: n=30; delayed: n=31). Both groups were similar in age (immediate: mean 61.3, SD 9.4 years; delayed: mean 62.1, SD 8.5 years) and body mass index (immediate: mean 29.2, SD 5.5 kg/m 2 ; delayed: mean 29.2, SD 4.8 kg/m 2 ). Contrast analyses revealed significant between-group effects in

  13. Use of computer technologies in physical education of women of the first mature age

    Directory of Open Access Journals (Sweden)

    Julia Tomilina

    2016-08-01

    Full Text Available Purpose: the improvement of process of physical education of women of the first mature age by means of Pilates with use of information technologies. Material & Methods: the experience of development and deployment of computer technologies in the process of physical education of women of mature age was systematized by means of the analysis of scientific and methodical and special literature and the best pedagogical and coach's practices, which is presented in mass media. The ways of application of computer programs were revealed, and the computer program ‘’Pilates’’ was developed by means of programming in the system Visual Basic. Results: the computer program ‘’Pilates’’, which consists of directory, settlement and recreational blocks, is offered for the purpose of improvement of the process of physical education of women of the first mature age by means of Pilates and increase in their motivation to classes by physical exercises. Conclusions: it is revealed that application of the computer programs has the positive effect in practice of physical education of women of the first mature age. The computer program ‘’Pilates’’ is submitted.

  14. Commercial Space with Technology Maturation

    Science.gov (United States)

    McCleskey, Carey M.; Rhodes, Russell E.; Robinson, John W.

    2013-01-01

    To provide affordable space transportation we must be capable of using common fixed assets and the infrastructure for multiple purposes simultaneously. The Space Shuttle was operated for thirty years, but was not able to establish an effective continuous improvement program because of the high risk to the crew on every mission. An unmanned capability is needed to provide an acceptable risk to the primary mission. This paper is intended to present a case where a commercial space venture could share the large fixed cost of operating the infrastructure with the government while the government provides new advanced technology that is focused on reduced operating cost to the common launch transportation system. A conceivable commercial space venture could provide educational entertainment for the country's youth that would stimulate their interest in the science, technology, engineering, and mathematics (STEM) through access at entertainment parks or the existing Space Visitor Centers. The paper uses this example to demonstrate how growing public-private space market demand will re-orient space transportation industry priorities in flight and ground system design and technology development, and how the infrastructure is used and shared.

  15. Health and human services in an age of maturity.

    Science.gov (United States)

    Aldridge, M G

    1986-12-01

    Catholic health care organizations are experiencing a tension between evangelical mission and expanding competition in medical markets. For the voluntary, not-for-profit health and human services system to survive and grow, hospital communities must find new revenue sources that do not create dependence on state and federal monies. The United States entered the Age of Maturity in 1985 as the "baby boomers" born between 1945 and 1957 became 40 years old, requiring health care providers to begin to plan for their care in old age. This large aging population, combined with a longer life span for Americans, will put increased burdens on health care organizations, particularly for chronic care, up to the year 2020 or beyond. Changes in family structure and social networks will be necessary as more people care for older relatives. The ratio of nonworkers to workers will increase, further burdening national and state tax bases, Social Security, and other worker-contributor programs. Investment banks are one option to finance the older population's increased needs for health and human services. Investment banks are funded by donations from the private sector (local and national businesses), the public sector (state, national, and local agencies), and new for-profit ventures for older persons. The contributions themselves remain in a central fund, with only the interest generated being used to fund local organizations committed to financial self-sufficiency and to helping the elderly. Older persons will carry increased economic and political clout in the Age of Maturity and will constitute a large percentage of hospitals' business. Therefore hospitals will have to develop a strong market position among the elderly. They must consider integrating a new service mix of both health and human services. Candidates for new hospital services for the elderly include housing programs, long-term care and continuum of care programs, employment programs, retirement planning, estate

  16. Green Propellant Infusion Mission Program Development and Technology Maturation

    Science.gov (United States)

    McLean, Christopher H.; Deininger, William D.; Joniatis, John; Aggarwal, Pravin K.; Spores, Ronald A.; Deans, Matthew; Yim, John T.; Bury, Kristen; Martinez, Jonathan; Cardiff, Eric H.; hide

    2014-01-01

    The NASA Space Technology Mission Directorate's (STMD) Green Propellant Infusion Mission (GPIM) Technology Demonstration Mission (TDM) is comprised of a cross-cutting team of domestic spacecraft propulsion and storable green propellant technology experts. This TDM is led by Ball Aerospace & Technologies Corp. (BATC), who will use their BCP- 100 spacecraft to carry a propulsion system payload consisting of one 22 N thruster for primary divert (DeltaV) maneuvers and four 1 N thrusters for attitude control, in a flight demonstration of the AF-M315E technology. The GPIM project has technology infusion team members from all three major market sectors: Industry, NASA, and the Department of Defense (DoD). The GPIM project team includes BATC, includes Aerojet Rocketdyne (AR), Air Force Research Laboratory, Aerospace Systems Directorate, Edwards AFB (AFRL), NASA Glenn Research Center (GRC), NASA Kennedy Space Center (KSC), and NASA Goddard Space Flight Center (GSFC). STMD programmatic and technology oversight is provided by NASA Marshall Space Flight Center. The GPIM project shall fly an operational AF-M315E green propulsion subsystem on a Ball-built BCP-100 spacecraft.

  17. Three stage maturity model in SME’s toward industry 4.0

    Energy Technology Data Exchange (ETDEWEB)

    Ganzarain, J.; Errasti, N.

    2016-07-01

    To address the challenges regarding the concept of Industry 4.0 and the diversification methodology and based on the strategic guidance towards Industry 4.0, we propose a process model as a guiding framework for Industry 4.0 collaborative diversification vision, strategy and action building. In this paper we suggest a stage process model to guide and train companies to identify new opportunities for diversification within Industry 4.0. Systematically carrying out the stages will take a company to their individual specific vision and collaborative vision between different companies in the Industry 4.0 scenario. Design/methodology/approach: This new collaborative diversification methodology involves industry within the pilot program; from the diversification and capacity assessment analysis of the companys profile, skills and technologies that dominates, to identify the diversification opportunity map and its business modeling within the Industry 4.0 paradigm. Findings: The application of maturity models to the Industry 4.0 may help organizations to integrate this methodology into their culture. Results show a real need for guided support in developing a company-specific Industry 4.0 vision and specific project planning. Originality/value: Industry 4.0 promotes a vision where recent developments in information technology are expected to enable entirely new forms of cooperative engineering and manufacturing. The vision of industry 4.0 describes a whole new approach to business operations, and especially the production industries. To address the challenges regarding the concept of Industry 4.0 and the diversification methodology discussed above, and based on the strategic guidance towards Industry 4.0, we propose a unique process model as a guiding framework for Industry 4.0 collaborative diversification vision, strategy and action building.

  18. Three stage maturity model in SME’s toward industry 4.0

    International Nuclear Information System (INIS)

    Ganzarain, J.; Errasti, N.

    2016-01-01

    To address the challenges regarding the concept of Industry 4.0 and the diversification methodology and based on the strategic guidance towards Industry 4.0, we propose a process model as a guiding framework for Industry 4.0 collaborative diversification vision, strategy and action building. In this paper we suggest a stage process model to guide and train companies to identify new opportunities for diversification within Industry 4.0. Systematically carrying out the stages will take a company to their individual specific vision and collaborative vision between different companies in the Industry 4.0 scenario. Design/methodology/approach: This new collaborative diversification methodology involves industry within the pilot program; from the diversification and capacity assessment analysis of the companys profile, skills and technologies that dominates, to identify the diversification opportunity map and its business modeling within the Industry 4.0 paradigm. Findings: The application of maturity models to the Industry 4.0 may help organizations to integrate this methodology into their culture. Results show a real need for guided support in developing a company-specific Industry 4.0 vision and specific project planning. Originality/value: Industry 4.0 promotes a vision where recent developments in information technology are expected to enable entirely new forms of cooperative engineering and manufacturing. The vision of industry 4.0 describes a whole new approach to business operations, and especially the production industries. To address the challenges regarding the concept of Industry 4.0 and the diversification methodology discussed above, and based on the strategic guidance towards Industry 4.0, we propose a unique process model as a guiding framework for Industry 4.0 collaborative diversification vision, strategy and action building.

  19. Purely Functional Structured Programming

    OpenAIRE

    Obua, Steven

    2010-01-01

    The idea of functional programming has played a big role in shaping today's landscape of mainstream programming languages. Another concept that dominates the current programming style is Dijkstra's structured programming. Both concepts have been successfully married, for example in the programming language Scala. This paper proposes how the same can be achieved for structured programming and PURELY functional programming via the notion of LINEAR SCOPE. One advantage of this proposal is that m...

  20. Maturity acceleration of Italian dried sausage by Staphylococcus carnosus - Relationship between maturity and flavor compounds

    DEFF Research Database (Denmark)

    Stahnke, Louise Heller; Holck, A.; Jensen, Anni

    2002-01-01

    . Sausages with S. carnosus 833 matured more than 2 wk faster than control sausages. Maturity correlated significantly with higher amounts of branched-chain aldehydes and alcohols and both branched- and straight-chain methyl ketones-compounds arising from the breakdown of the amino acids leucine, isoleucine...

  1. IT Governance Maturity: Developing a Maturity Model Using the Delphi Method

    NARCIS (Netherlands)

    Smits, Daniël; van Hillegersberg, Jos

    2015-01-01

    To advance in maturity, organizations should pay attention to both the hard and soft sides of IT governance (ITG). The hard side is related to processes and structure, the soft side to social aspects like behavior and organizational culture. This paper describes a study to develop an ITG maturity

  2. TRIPOLI I: energy-dependent three-dimensional Monte Carlo Program. Volume I. Conception and presentation of the TRIPOLI I System

    International Nuclear Information System (INIS)

    Katz, S.; Nimal, J.C.

    In its present version TRIPOLI/1/ is an energy dependent three-dimensional program which treats the slowing down and diffusion of neutrons for source problems. The version presented here is essentially oriented towards reactor shielding problems. It is written in FORTRAN for IBM (series 360) computer. This volume is devoted to a summary of the essential characteristics of the program as well as to a description of the constants required for the description of the chaining together of the work to be carried out

  3. Westinghouse AP1000 licensing maturity

    International Nuclear Information System (INIS)

    Schulz, T.; Vijuk, R.P.

    2005-01-01

    The Westinghouse AP1000 Program is aimed at making available a nuclear power plant that is economical in the U.S deregulated electrical power industry in the near-term. The AP1000 is two-loop 1000 MWe pressurizer water reactor (PWR). It is an up rated version of the AP600. The AP1000 uses passive safety systems to provide significant and measurable improvements in plant simplification, safety, reliability, investment protection and plant costs. The AP1000 uses proven technology, which builds on over 35 years of operating PWR experience. The AP1000 received Final Design Approval by the United States Nuclear Regulatory Commission (U.S. NRC) in September 2004. The AP1000 meets the US utility requirements. The AP1000 and its sister plant the AP600 have gone through a very through and complete licensing review. This paper describes the U.S. NRC review efforts of both the AP600 and the AP1000. The detail of the review and the independent calculations, evaluations and testing is discussed. The AP600 licensing documentation was submitted in 1992. The U.S. NRC granted Final Design Approval in 1999. During the intervening 7 years, the U.S. NRC asked thousands of questions, performed independent safety analysis, audited Westinghouse calculations and analysis, and performed independent testing. The more significant areas of discussion will be described. For the AP1000 Westinghouse first engaged the U.S. NRC in pre-certification discussions to define the extent of the review required, since the design is so similar to the AP600. The AP1000 licensing documentation was submitted in March 2002. The U.S. NRC granted Final Design Approval in September 2004. During the intervening 2 1/2 years, the U.S. NRC asked hundreds of questions, performed independent safety analysis, audited Westinghouse calculations and analysis, and performed independent testing. The more significant areas of discussion will be described. The implications of this review and approval on AP1000 applications in

  4. [Maturation diagnosis in full term hypotrophic fetuses].

    Science.gov (United States)

    Scharnke, H D; Gartzke, J; Fleischer, G; Isbruch, E

    1977-01-01

    Foam-Test by Clements is a valuable method for determining the foetus maturity of lungs. We introduce this test along with other parameters for the maturity-diagnosis since one year. In 15% result, the Foam-Test was not applicable because of blood, or meconic amniotic fluid, other wise wrong negative and in 0% wrong positive results. By unmatured child, there was doubtable results with Foam-Test. Since it is important to determine the early delivery of unmatured children, particularly the case of foetus maturity of lungs must be exact, we therefore decided to use the Lecithin/Sphingomyelinquotients in some cases. The results of Lecithin/Sphingomyelinquotient in unmatured children are almost with the approximated date under two. From this, one must deduce from these children, that the intrauterine unmatured lungs lately took place.

  5. Capability maturity models for offshore organisational management.

    Science.gov (United States)

    Strutt, J E; Sharp, J V; Terry, E; Miles, R

    2006-12-01

    The goal setting regime imposed by the UK safety regulator has important implications for an organisation's ability to manage health and safety related risks. Existing approaches to safety assurance based on risk analysis and formal safety assessments are increasingly considered unlikely to create the step change improvement in safety to which the offshore industry aspires and alternative approaches are being considered. One approach, which addresses the important issue of organisational behaviour and which can be applied at a very early stage of design, is the capability maturity model (CMM). The paper describes the development of a design safety capability maturity model, outlining the key processes considered necessary to safety achievement, definition of maturity levels and scoring methods. The paper discusses how CMM is related to regulatory mechanisms and risk based decision making together with the potential of CMM to environmental risk management.

  6. Mature Oocyte Cryopreservation for Fertility Preservation.

    Science.gov (United States)

    Liang, Tina; Motan, Tarek

    2016-01-01

    In recent decades, advances in cancer treatment have led to a dramatic improvement in long term survival. This has led to an increasing focus on quality of life after surviving cancer treatment, with fertility being an important aspect. Given the known reproductive risks of cancer therapies, there has been a growing interest in the field of fertility preservation (also referred to as oncofertility). Mature oocyte cryopreservation is no longer considered experimental and has become a realistic option for reproductive aged women prior to undergoing cancer treatment. Additionally, as cryopreservation techniques improve, mature oocyte cryopreservation is increasing being marketed to healthy women without cancer wishing to delay child bearing, also termed "social egg freezing". This chapter provides a review of the current technology, use, and outcomes of mature oocyte cryopreservation. It also outlines the ethical debate surrounding social egg freezing and directions for future research in female fertility preservation.

  7. Genetic transformation of mature citrus plants.

    Science.gov (United States)

    Cervera, Magdalena; Juárez, José; Navarro, Luis; Peña, Leandro

    2005-01-01

    Most woody fruit species have long juvenile periods that drastically prolong the time required to analyze mature traits. Evaluation of characteristics related to fruits is a requisite to release any new variety into the market. Because of a decline in regenerative and transformation potential, genetic transformation procedures usually employ juvenile material as the source of plant tissue, therefore resulting in the production of juvenile plants. Direct transformation of mature material could ensure the production of adult transgenic plants, bypassing in this way the juvenile phase. Invigoration of the source adult material, establishment of adequate transformation and regeneration conditions, and acceleration of plant development through grafting allowed us to produce transgenic mature sweet orange trees flowering and bearing fruits in a short time period.

  8. The innovative viscoelastic CP ESP cervical disk prosthesis with six degrees of freedom: biomechanical concepts, development program and preliminary clinical experience.

    Science.gov (United States)

    Lazennec, Jean-Yves; Aaron, Alain; Ricart, Olivier; Rakover, Jean Patrick

    2016-01-01

    The viscoelastic cervical disk prosthesis ESP is an innovative one-piece deformable but cohesive interbody spacer. It is an evolution of the LP ESP lumbar disk implanted since 2006. CP ESP provides six full degrees of freedom about the three axes including shock absorbtion. The prosthesis geometry allows limited rotation and translation with resistance to motion (elastic return property) aimed at avoiding overload of the posterior facets. The rotation center can vary freely during motion. The concept of the ESP prosthesis is fundamentally different from that of the devices currently used in the cervical spine. The originality of the concept of the ESP® prosthesis led to innovative and intense testing to validate the adhesion of the viscoelastic component of the disk on the titanium endplates and to assess the mechanical properties of the PCU cushion. The preliminary clinical and radiological results with 2-year follow-up are encouraging for pain, function and kinematic behavior (range of motion and evolution of the mean centers of rotation). In this series, we did not observe device-related specific complications, misalignment, instability or ossifications. Additional studies and longer patient follow-up are needed to assess long-term reliability of this innovative implant.

  9. Vegetative propagation of mature and juvenile northern red oak

    Science.gov (United States)

    James J. Zaczek; K. C. Steiner; C. W., Jr. Heuser

    1993-01-01

    Rooting trials were established to evaluate rooting success of cuttings from mature and juvenile, grafted and ungrafted northern red oak (NRO). Buds from 4 mature NRO ortets and juvenile seedlings were grafted onto juvenile and mature rootstock. Cuttings were collected from the grafts and from juvenile and mature shoots developed in situ and...

  10. How Title IX and Proportionality Population Concepts Have Equalized Collegiate Women's Sports Programs with Men's Sports and Allows Spillover Gains for Women in the Workplace

    Science.gov (United States)

    Compton, Nina H.; Compton, J. Douglas

    2010-01-01

    Title IX of the Education Reformation Act was passed in 1972 for the purpose of providing equality between males and females in intercollegiate sports. Since its inception the disparity between men's and women's varsity athletics programs has persisted throughout American colleges and universities. Discrimination and equal protection concerns…

  11. The Integration of International Agricultural Concepts into Agricultural Science Programs in the North Central Region of the United States. Summary of Research 78.

    Science.gov (United States)

    Ibezim, Don O.; McCracken, J. David

    A study examined the extent to which international agricultural dimensions were taught in secondary agricultural programs and factors associated with the extent of integration. A systematic sampling technique was used to select a random sample of 332 of the 2,612 secondary agricultural teachers in 12 states of the North Central United States. Of…

  12. The National Shipbuilding Research Program 1985 Ship Production Symposium Volume 2 Paper No. 22: Expanded Planning Yard Concept and Configuration Accounting or Improving Navy Ship Engineering

    National Research Council Canada - National Science Library

    1985-01-01

    .... Requirements for ship acquisition programs have been refined to reflect these improvements. We have learned that there is a need for clearly assigned responsibility in engineering, that configuration identification must be an integral part of engineering, and that logistics support must be an integral part of engineering.

  13. Digital Maturity of the Firm's Business Model

    DEFF Research Database (Denmark)

    Groskovs, Sergejs; Vemula, Sreekanth

    We propose a digital maturity assessment model as an instrument for researchers and a strategic tool for managers. Existing literature lacks a conceptually clear way to measure the construct of digital maturity at the level of the firms business model. Our proposed instrument thus opens avenues...... for research into questions related to antecedents, process, and performance outcomes of the digitalization of business activities. The assessment follows the logic of first decomposing the business model into the underlying value creation activities and then evaluating the levels of automation...

  14. Posttesticular sperm maturation, infertility, and hypercholesterolemia

    Directory of Open Access Journals (Sweden)

    Marjorie Whitfield

    2015-01-01

    Full Text Available Cholesterol is a key molecule in the mammalian physiology of especial particular importance for the reproductive system as it is the common precursor for steroid hormone synthesis. Cholesterol is also a recognized modulator of sperm functions, not only at the level of gametogenesis. Cholesterol homeostasis regulation is crucial for posttesticular sperm maturation, and imbalanced cholesterol levels may particularly affect these posttesticular events. Metabolic lipid disorders (dyslipidemia affect male fertility but are most of the time studied from the angle of endocrine/testicular consequences. This review will focus on the deleterious effects of a particular dyslipidemia, i.e., hypercholesterolemia, on posttesticular maturation of mammalian spermatozoa.

  15. Information systems in Chernobyl accident after-effect elimination: On the way from youth to maturity

    International Nuclear Information System (INIS)

    Chabanyuk, V.S.; Proskura, N.I.; Tabachny, L.Ya.

    1997-01-01

    10-years period of Information Systems in the Chernobyl Accident after-effects elimination (these systems we name Chernobyl Information Systems (ChIS) for simplicity of reference) creation is analyzed. It is claimed that ChIS are introducing into the maturity phase now. The paper consists of Introduction, four paragraphs and Conclusion. Short history of ChIS creation on the example of radioecological component is described in Introduction. Two phases: youth and maturity, are identified. The youth phase is divided on three periods: 1986-1988, 1988-1992, 1993-1995. The maturity phase has started in 1994 with accepting of new Conception of ChIS implementation. Main characteristics of each phase and period are described

  16. Object recognition and concept learning with Confucius

    Energy Technology Data Exchange (ETDEWEB)

    Cohen, B; Sammut, C

    1982-01-01

    A learning program produces, as its output, a Boolean function which describes a concept. The function returns true if and only if the argument is an object which satisfies the logical expression in the body of the function. The learning program's input is a set of objects which are instances of the concept to be learnt. The paper describes an algorithm devised to learn concept descriptions in this form. 15 references.

  17. Dual coolant blanket concept

    International Nuclear Information System (INIS)

    Malang, S.; Schleisiek, K.

    1994-11-01

    A self-cooled liquid metal breeder blanket with helium-cooled first wall ('Dual Coolant Blanket Concept') for a fusion DEMO reactor is described. This is one of the four blanket concepts under development in the frame of the European fusion technology program with the aim to select in 1995 the two most promising ones for further development. Described are the design of the blankets including the ancillary loop system and the results of the theoretical and experimental work in the fields of neutronics, magnetohydrodynamics, thermohydraulics, mechanical stresses, compatibility and purification of lead-lithium, tritium control, safety, reliability, and electrically insulating coatings. The remaining open questions and the required R and D programme are identified. (orig.) [de

  18. Concept for creating program-technical complex of safety monitoring with system of safety parameters presentation functions on the basis of routine WWER-1000 systems

    International Nuclear Information System (INIS)

    Dunaev, V.G.; Tarasov, M. V.; Povarov, P.V.

    2005-01-01

    Prerequisites of creating the software-hardware complex for reactor safety monitoring on the Volgodonsk NPP are analyzed and generalized. The concept of this complex is based on functions of the safety parameters presentation system. It will serve as an interface between operator and technological process and give to operator a possibility to estimate quickly the state of the safety of the nuclear power unit. The complex will be created on the basis of routine reactor monitoring and control systems intended for the WWER-1000 reactor. In addition to existing soft- and hard-wares for reactor monitoring and for analysis of technological archive, it is proposed to create and connect in parallel the new software-hardware complex which ensures calculation and presentation of generalized factors of reactor safety [ru

  19. Program “VAMOS” (Active Living, Enhancing Health: from conception to initial findings DOI: http://dx.doi.org/10.5007/1980-0037.2012v14n6p723

    Directory of Open Access Journals (Sweden)

    Luiz Salomão Ribas Gomez

    2012-11-01

    Full Text Available Despite increased governmental efforts towards promoting healthy and active lifestylesamong Brazilians, physical inactivity is a serious concern in the population. Therefore, wedeveloped a new approach to community interventions for the promotion of physical activitycalled “Project VAMOS: Active Living, Enhancing Health”. In this article we review information about the conception of the program, as well as name, brand, and logo development. We discussissues related to translation and cultural adaptation, evaluation strategies, and we review lessonslearned from the pilot phase of the project that involved older adults and public health centers(CS in Florianopolis. One hundred older adults registered in six CS participated in the pilot study.They were randomly assigned into three different groups: “VAMOS” (n=33, traditional physicalactivity classes (n=35, and a control group (n=32. “VAMOS” is an educational program basedon behavioral change principles that consists of 12 meetings. Based on an American evidence--based program (“Active Living Every Day”, “VAMOS” was translated and culturally adaptedto the Brazilian context. A number of adjustments were made to the original American versionof the program prior to conducting the pilot study. For example, the content of the lessons andhomework were revised, we shortened the length of the lessons, as well as lowered the complexityof some of the materials. The results of the pilot study suggest that there was broad acceptanceof the “VAMOS“program by the older adult participants. Also, interviews with administrativestaff and health professionals working for the CS indicated a possibility and interest to continueto offer “VAMOS” as part of their regular programming for the community. In summary, “VAMOS”has great potential to be used with the Brazilian population. Adjustments are necessaryfor its utilization with other age groups and across different regions in Brazil.

  20. Technical Meeting on Developing Deep-Burn Concepts using HTGRs. Objectives and Expectations

    International Nuclear Information System (INIS)

    Tyobeka, Bismark

    2013-01-01

    The objectives of the meeting are: • To explore various Deep-Burn options and concepts being developed in Member States; • To appraise the progress made towards the maturity of Deep-Burn concepts based on HTGR designs; • To identify technology development challenges towards the realization of Deep-Burn concepts; • To propose collaborative ways to address technology development challenges

  1. 職業取向生涯教育課程對國中學習遲緩學生生涯成熟之影響 The Effect of Vocation-Oriented Career Program on Career Maturity of Junior High Slow Learners

    Directory of Open Access Journals (Sweden)

    程國選 Kuo-Hsuan Cheng

    2009-03-01

    Full Text Available 本研究的目的在探討Brolin(1997)生活中心生涯教育(Life-Centered Career Education, LCCE)的理論模式和學習遲緩者的學習行為特質,據以編擬一套適合國中學習遲緩學生學習活動的職業取向生涯教育課程(Vocation Oriented Career Program, VOCP),以等組法前後測實驗設計,考驗這套課程對學生生涯成熟的效果。結果顯示:一、接受生涯教育的學習遲緩學生在生涯發展態度、生涯發展認知及生涯發展取向等三項生涯成熟評量上,顯著優於未接受此種課程者;二、接受生涯教育的女生,在生涯發展認知的效果優於男生,其餘兩項生涯成熟評量則無顯著性別差異;三、實驗教學後的追蹤評量顯示,生涯教育對學習遲緩學生的生涯發展有持續的正向效果。最後,根據研究發現,研究者對於教師教學、教育行政與後續研究提出建言。 The purposes of this study were twofold: (1 to develop the Vocation-Oriented Career Program (VOCP based the model of Life Centered Career Education (Brolin, 1997 and the learning characteristics of slow learners; and (2 to explore the effect of VOCP learning activities on career maturity of junior high slow learners. A pre- and post-test experimental design was adopted. The major findings of this study were as follows: (1 The VOCP had significantly effects on slow learners’ career development attitude, career development cognition, and career development orientation. (2 Among three measures of career maturity, there was only the career development cognition showed gender difference, i.e., females were superior to males. (3 An 8-week follow-up test showed the lasting effects of the experiment on all three measures of VOCP. Based on the findings, suggestions for teacher’s instruction, educational administration, and further researches were made.

  2. Dignity and informed consent in the treatment of mature minors.

    Science.gov (United States)

    Bello, Bidemi Ademola

    2010-12-01

    In today's world, as evinced in various human rights provisions, emphasis is placed on the assertion and protection of the entrenched rights of every human and particularly the dignity of humans and respect of human autonomy. Medical/health workers are concerned about protecting every patient's right to the dignity of his or her person. This led to the formulation of the concept of self determination and informed consent in medical diagnosis and treatments. However, serious concern is placed on these principles especially as it affects mature minors, a group of individuals who by conduct demand a level of respect but may at the same time be viewed as not capable of making the "best" informed decisions, especially about health. The following issues may arise as a result of the aforementioned concerns: --are mature young ones entitled to right of self determination and informed consent despite the alleged fear that they may lack capacity to make informed decisions? --if no, who should decide on their behalf--their parents, their medical/health provider or the society/government (especially since the 3 (three) interested groups may have different and conflicting stands on what is best for the child); --if the answer to the initial question is yes, to what extent should mature minors be informed of their medical choices and be allowed to exercise their right of self determination? --should they be guided? --and who should so guide them? In resolving the above issue, due consideration has been given not only to legal and bio-ethical provisions of some countries but also to international conventions which several countries are party to. Thereafter, it became clear that most authorities are of the view that mature minors should be fully informed and be allowed to have a say in health decisions, coaching them with few exceptions. Ultimately, because of the importance of respect for human dignity, autonomy and self determination along with medical disclosure in today

  3. Mathematical concepts

    CERN Document Server

    Jost, Jürgen

    2015-01-01

    The main intention of this book is to describe and develop the conceptual, structural and abstract thinking of mathematics. Specific mathematical structures are used to illustrate the conceptual approach; providing a deeper insight into mutual relationships and abstract common features. These ideas are carefully motivated, explained and illustrated by examples so that many of the more technical proofs can be omitted. The book can therefore be used: ·         simply as an overview of the panorama of mathematical structures and the relations between them, to be supplemented by more detailed texts whenever you want to acquire a working knowledge of some structure ·         by itself as a first introduction to abstract mathematics ·         together with existing textbooks, to put their results into a more general perspective ·         to gain a new and hopefully deeper perspective after having studied such textbooks Mathematical Concepts has a broader scope and is less detaile...

  4. Maturity analysis of the innovation system in the livestock industries of West Sumatra, Indonesia

    Science.gov (United States)

    Suresti, A.; Dinata, U. G. S.; Wati, R.

    2018-02-01

    The main objective of this study was to analyse the ANIS of Livestock industry in West Sumatera according to its main determinants. This research aims to know and understand the maturity level of the regional innovationsystem of West Sumatra livestock industries, including recommendation for improvements. The maturity level of the regional innovation system was analyzed with the ANIS method by using an opinion survey to some experts from businessmen, government and universities. This expert opinion survey was conducted to measure expert perceptions on the implementations of determinants of west Sumatera regional innovations systems on livestock industries on macro level (innovations policy), mezzo level (innovation institutions and programs) and micro level (innovation capacity). By using Likert method, the result showed maturity level for the West Sumatra livestock industries innovation system was still develop. This is caused by low maturity in the macro and meso determinants which are at the central and regional government side. This research result may be useful as recommendations for the government for improving the maturity level and may be a basic for incoming researches to identify regional innovation system determinants with low maturity to improve.

  5. Pediatric Ankle Fractures: Concepts and Treatment Principles

    Science.gov (United States)

    Su, Alvin W.; Larson, A. Noelle

    2016-01-01

    Synopsis Current clinical concepts are reviewed regarding the epidemiology, anatomy, evaluation and treatment of pediatric ankle fractures. Correct diagnosis and management relies on appropriate exam, imaging, and knowledge of fracture patterns specific to children. Treatment is guided by patient history, physical examination, plain film radiographs and, in some instances, CT. Treatment goals are to restore acceptable limb alignment, physeal anatomy, and joint congruency. For high risk physeal fractures, patients should be monitored for growth disturbance as needed until skeletal maturity. PMID:26589088

  6. Elevated Social Anxiety among Early Maturing Girls

    Science.gov (United States)

    Blumenthal, Heidemarie; Leen-Feldner, Ellen W.; Babson, Kimberly A.; Gahr, Jessica L.; Trainor, Casey D.; Frala, Jamie L.

    2011-01-01

    Adolescence is a key period in terms of the development of anxiety psychopathology. An emerging literature suggests that early pubertal maturation is associated with enhanced vulnerability for anxiety symptomatology, although few studies have examined this association with regard to social anxiety. Accordingly, the current study was designed to…

  7. Mature cystic teratomas: Relationship between histopathological ...

    African Journals Online (AJOL)

    ... tumor size, symptoms related to MCT and laterality of the tumor did not differ among the patients according to the MCT contents. Conclusions: Our findings suggest no relationship between the clinical features and histopathological contents of MCTs. Key words: Histopathological contents, mature cystic teratoma, ovarian, ...

  8. Teaching Copywriting Students about the Mature Market.

    Science.gov (United States)

    Drewniany, Bonnie

    Advertising educators have a responsibility to make students aware of the importance of the mature market (older people) and to teach them methods to reach this group. An assignment in a copywriting class asked students to write and design ads to promote blue jeans to adults over 50. The assignment accomplished three things: (1) helped students…

  9. Plant regeneration in wheat mature embryo culture

    African Journals Online (AJOL)

    Kamil Haliloğlu

    2011-11-09

    Nov 9, 2011 ... Success in genetic engineering of cereals depends on the callus formation and efficient plant regeneration system. Callus formation and plant regeneration of wheat mature embryos ... compiled by modification of methods previously mentioned in ..... of more and readily available nutrition than artificial cul-.

  10. GROWTH PATTERNS AND MATURATION OF CHILDREN WITH ...

    African Journals Online (AJOL)

    GROWTH PATTERNS AND MATURATION OF CHILDREN WITH SICKLE CELL DISEASE IN RELATION TO PLASMA ZINC STATUS. Dr. Salwa R. El Batrawy, Dr. Mervat Tawfik M. Tantawi. Full Text: EMAIL FULL TEXT EMAIL FULL TEXT · DOWNLOAD FULL TEXT DOWNLOAD FULL TEXT.

  11. 7 CFR 51.2841 - Mature.

    Science.gov (United States)

    2010-01-01

    ... Regulations of the Department of Agriculture AGRICULTURAL MARKETING SERVICE (Standards, Inspections, Marketing Practices), DEPARTMENT OF AGRICULTURE REGULATIONS AND STANDARDS UNDER THE AGRICULTURAL MARKETING ACT OF 1946... considered mature when harvested in accordance with good commercial practice at a stage which will not result...

  12. The influence of biological maturation on anthropometric ...

    African Journals Online (AJOL)

    The aim of this study was to determine whether biological maturation would significantly influence the anthropometric determinants of talent identification among U-14 provincial girl tennis players. Twenty-six of the top thirty-two provincial female players (mean age = 13.21± 0.72 years) from the Northern Gauteng and the ...

  13. 7 CFR 51.1823 - Mature.

    Science.gov (United States)

    2010-01-01

    ... Industry, Part 1, Chapter 20-13 Market Classification, Maturity Standards and Processing or Packing... Independence Ave., Washington, DC 20250 or at the National Archives and Records Administration (NARA). For information on the availability of this material at NARA, call 202-741-6030, or go to: http://www.archives.gov...

  14. 7 CFR 51.767 - Mature.

    Science.gov (United States)

    2010-01-01

    ... Florida Citrus Industry, Part 1, Chapter 20-13 Market Classification, Maturity Standards and Processing or... 2065-S, 14th and Independence Ave., Washington, DC 20250 or at the National Archives and Records...: http://www.archives.gov/federal_register/code_of_federal_regulations/ibr_locations.html. ...

  15. 7 CFR 51.1158 - Mature.

    Science.gov (United States)

    2010-01-01

    ... Citrus Industry, Part 1, Chapter 20-13 Market Classification, Maturity Standards and Processing or... 2065-S, 14th and Independence Ave., Washington, DC 20250 or at the National Archives and Records...: http://www.archives.gov/federal_register/code_of_federal_regulations/ibr_locations.html. ...

  16. Analyzing Project Management Maturity Level in Indonesia

    Directory of Open Access Journals (Sweden)

    Eliot Simangunsong

    2013-04-01

    Full Text Available Project management has been generally known and increasingly used by many organizations to gain competitive advantage. In this context, many studies have proposed maturity models to evaluate how project management knowledge has been deployed effectively and efficiently in or- ganization. As a developing country, Indonesia needs many development projects managed by government and private companies in different industries. Here, a study to assess project manage- ment maturity level in Indonesian businesses may bring insight about current business practices, which is important to speed up country development and business sustainability. Adapting the Project Management Maturity Model (ProMMM, a survey instrument has been developed and ap- plied to professionals from Jakarta and surrounding area. The result of analysis shows that con- struction and primary industry have a higher maturity level compare to manufacturing and servic- es. It is to be noted, however, that the level of project management understanding is low across in- dustries. This indicates that more quality project management training or certification is required to improve overall project management knowledge in Indonesia.

  17. Maturation of human oocytes in vitro

    Directory of Open Access Journals (Sweden)

    Mojca Čižek-Sajko

    2007-01-01

    Full Text Available Background: Immature oocyte retrieval followed by in vitro maturation is a promising infertility treatment option. In patients with morphologically normal ovaries and regular menstrual cycles and in patients with polycystic ovary syndrome (PCOS we attempted to assess the success of oocyte in vitro maturation in in vitro fertilization (IVF procedures.Methods: Retrospectively we analyzed 87 IVF procedures with in vitro maturation of oocytes carried out in 73 infertile couples treated at the Maribor Teaching Hospital. We compared the success following three different hormone priming protocols: regular cycling patients with normal ovaries and without hormone priming (Group A, n = 27; patients with PCOS and hormone priming with follitropin (follicle stimulating hormone, FSH (Group B, n = 22; patients with PCOS and hormone priming with human chorionic gonadotrophin (hCG (Group C, n = 38. Success of the procedure was evaluated on the basis of the ability of oocytes to mature, fertilize and develop into embryos, and on the basis of the quality of embryos and their ability to implant in the uterus.Results: In regular cycling patients with normal ovaries (n = 27 we obtained a significantly lower number of immature oocytes (3.2 ± 2.5 compared with patients with PCOS and FSH priming (11.7 ± 7.2 or those with PCOS and hCG priming (10.4 ± 7.2. The oocyte maturation rate, the fertilization rate and the embryo cleavage rate were as follows: in Group A 57.7 %, 63.2 % and 91.7 %, in Group B 57.6 %, 66.2 % and 90.0 %, and in Group C 58.0 %, 66.2 % and 91.0 % (the differences between groups were not statistically significant. Six pregnancies were recorded only in patients with PCOS. The pregnancy rate per embryo transfer was 1/20 (5.0 % in patients with FSH priming, and 5/33 (15.2 % in patients with hCG priming.Conclusions: Oocyte in vitro maturation is successful in patients with normal ovaries and regular menstrual cycle as well as in those with polycystic

  18. Advanced divertor concepts

    International Nuclear Information System (INIS)

    Ohyabu, N.; Komori, A.; Sagara, A.; Suzuki, H.; Morisaki, T.; Masuzaki, S.; Watanabe, T.; Noda, N.; Motojima, O.

    1996-01-01

    LHD divertor development program has generated various innovative divertor concepts and technologies which will help to improve the plasma performance in both helical and tokamak devices. They are two divertor operational scenarios (confinement improvement by generating high temperature divertor plasma and simultaneous achievement of radiative cooling and H-mode-like confinement improvement). Local island divertor geometry has also been proposed. This new divertor has been successfully tested in the CHS device and is planned to be installed in the LHD device. In addition, technological development of new efficient hydrogen pumping schemes (carbon sheet pump and membrane pump) are being pursued for enhancement of the divertor control capability. 17 refs., 8 figs

  19. A Drosophila Model to Image Phagosome Maturation

    Directory of Open Access Journals (Sweden)

    Douglas A. Brooks

    2013-03-01

    Full Text Available Phagocytosis involves the internalization of extracellular material by invagination of the plasma membrane to form intracellular vesicles called phagosomes, which have functions that include pathogen degradation. The degradative properties of phagosomes are thought to be conferred by sequential fusion with endosomes and lysosomes; however, this maturation process has not been studied in vivo. We employed Drosophila hemocytes, which are similar to mammalian professional macrophages, to establish a model of phagosome maturation. Adult Drosophila females, carrying transgenic Rab7-GFP endosome and Lamp1-GFP lysosome markers, were injected with E. coli DH5α and the hemocytes were collected at 15, 30, 45 and 60 minutes after infection. In wild-type females, E. coli were detected within enlarged Rab7-GFP positive phagosomes at 15 to 45 minutes after infection; and were also observed in enlarged Lamp1-GFP positive phagolysosomes at 45 minutes. Two-photon imaging of hemocytes in vivo confirmed this vesicle morphology, including enlargement of Rab7-GFP and Lamp1-GFP structures that often appeared to protrude from hemocytes. The interaction of endosomes and lysosomes with E. coli phagosomes observed in Drosophila hemocytes was consistent with that previously described for phagosome maturation in human ex vivo macrophages. We also tested our model as a tool for genetic analysis using 14-3-3e mutants, and demonstrated altered phagosome maturation with delayed E. coli internalization, trafficking and/or degradation. These findings demonstrate that Drosophila hemocytes provide an appropriate, genetically amenable, model for analyzing phagosome maturation ex vivo and in vivo.

  20. Implementation of the monitor concept

    Energy Technology Data Exchange (ETDEWEB)

    Gerstenberger, M.

    1982-01-01

    Sequential and parallel computer programs are contrasted, and the problems of implementing compilers are stated, with special reference to the Pascal language. Process and monitor data types in computer programming are described, various procedures are listed and the monitor concept is applied to a generator-user problem. A Pascal initiator program is listed. It is claimed that the monitor approach can yield lower fault levels than assembler or semaphore approaches. It is pointed out that monitors for program synchronisation are only applicable for common, and not for distributed, storage systems. 9 references.

  1. 7 CFR 1436.13 - Loan installments, delinquency, and acceleration of maturity date.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 10 2010-01-01 2010-01-01 false Loan installments, delinquency, and acceleration of... FACILITY LOAN PROGRAM REGULATIONS § 1436.13 Loan installments, delinquency, and acceleration of maturity... delinquency, CCC may permit a rescheduling of the debt or other measures consistent with the collection of...

  2. Demonstrating a correlation between the maturity of road safety practices and road safety incidents.

    Science.gov (United States)

    Amador, Luis; Willis, Christopher Joseph

    2014-01-01

    The objective of this study is to demonstrate a correlation between the maturity of a country's road safety practices and road safety incidents. Firstly, data on a number of road injuries and fatalities for 129 countries were extracted from the United Nations Global Status on Road Safety database. These data were subdivided according to road safety incident and accident causation factors and normalized based on vehicular fleet (per 1000 vehicles) and road network (per meter of paved road). Secondly, a road safety maturity model was developed based on an adaptation of the concept of process maturity modeling. The maturity of countries with respect to 10 road safety practices was determined through the identification of indicators recorded in the United Nations Global Status of Road Safety Database. Plots of normalized road safety performance of the 129 countries against their maturity scores for each road safety practice as well as an aggregation of the road safety practices were developed. An analysis of variance was done to determine the extent of the correlation between the road safety maturity of the countries and their performance. In addition, a full Bayesian analysis was done to confirm the correlation of each of the road safety practices with injuries and fatalities. Regression analysis for fatalities, injuries, and combined accidents identified maturity with respect to road safety practices associated with speed limits and use of alternative modes as being the most significant predictors of traffic fatalities. A full Bayesian regression confirms that there is a correlation between the maturity of road safety practices and road safety incidents. Road safety practices associated with enforcement of speed limits and promotion of alternative modes are the most significant road safety practices toward which mature countries have concentrated their efforts, resulting in a lower frequency of fatalities, injury rates, and property damage accidents. The authors

  3. A shuttle and space station manipulator system for assembly, docking, maintenance, cargo handling and spacecraft retrieval (preliminary design). Volume 3: Concept analysis. Part 2: Development program

    Science.gov (United States)

    1972-01-01

    A preliminary estimate is presented of the resources required to develop the basic general purpose walking boom manipulator system. It is assumed that the necessary full scale zero g test facilities will be available on a no cost basis. A four year development effort is also assumed and it is phased with an estimated shuttle development program since the shuttle will be developed prior to the space station. Based on delivery of one qualification unit and one flight unit and without including any ground support equipment or flight test support it is estimated (within approximately + or - 25%) that a total of 3551 man months of effort and $17,387,000 are required.

  4. Famulaturreife: Eine Idee auf dem Prüfstand [Clerkship maturity: Does the idea of training clinical skills work?

    Directory of Open Access Journals (Sweden)

    Stosch, Christoph

    2011-08-01

    Full Text Available [english] Background: With the reformed curriculum “4C”, the Medical Faculty of the University of Cologne has started to systematically plan practical skills training, for which Clerkship Maturity is the first step. The key guidelines along which the curriculum was development were developed by experts. This approach has now been validated. Materials and methods: Both students and teachers were asked to fill in a questionnaire regarding preclinical practical skills training to confirm the concept of Clerkship Maturity. Results and discussion: The Cologne training program Clerkship Maturity can be validated empirically overall through the activities of the students awaiting the clerkship framework and through the evaluation by the medical staff providing the training. The subjective ratings of the advantages of the training by the students leave room for improvement. Apart from minor improvements to the program, the most likely solution providing sustainable results will involve an over-regional strategy for establishing skills training planned as part of the curriculum.[german] Hintergrund: Mit dem Modellstudiengang Humanmedizin hat die Medizinische Fakultät der Universität zu Köln begonnen, die praktische Ausbildung, deren erster Schritt die „Famulaturreife“ ist, systematisch zu planen. Dabei wurden die handlungsleitenden Strukturen, entlang derer das Curriculum entwickelt wurde, auf Experteneinschätzung basierend entworfen. Dieses Vorgehen wurde nun einer Validierung unterworfen.Material und Methode: Sowohl Studierende als auch Lehrende wurden mit einem Fragebogen zur Ausbildung in Praktischen Fertigkeiten konfrontiert, um das Konstrukt „Famulaturreife“ zu bestätigen. Ergebnisse und Diskussion: Das Kölner Ausbildungsprogramm zur „Famulaturreife“ kann insgesamt empirisch durch die Tätigkeiten der Studierenden im Rahmen der Famulatur sowie durch die Einschätzung seitens der ausbildenden Ärzte bestätigt werden. Der

  5. From Perceptual Categories to Concepts: What Develops?

    Science.gov (United States)

    Sloutsky, Vladimir M.

    2010-01-01

    People are remarkably smart: they use language, possess complex motor skills, make non-trivial inferences, develop and use scientific theories, make laws, and adapt to complex dynamic environments. Much of this knowledge requires concepts and this paper focuses on how people acquire concepts. It is argued that conceptual development progresses from simple perceptual grouping to highly abstract scientific concepts. This proposal of conceptual development has four parts. First, it is argued that categories in the world have different structure. Second, there might be different learning systems (sub-served by different brain mechanisms) that evolved to learn categories of differing structures. Third, these systems exhibit differential maturational course, which affects how categories of different structures are learned in the course of development. And finally, an interaction of these components may result in the developmental transition from perceptual groupings to more abstract concepts. This paper reviews a large body of empirical evidence supporting this proposal. PMID:21116483

  6. Leveraging People-Related Maturity Issues for Achieving Higher Maturity and Capability Levels

    Science.gov (United States)

    Buglione, Luigi

    During the past 20 years Maturity Models (MM) become a buzzword in the ICT world. Since the initial Crosby's idea in 1979, plenty of models have been created in the Software & Systems Engineering domains, addressing various perspectives. By analyzing the content of the Process Reference Models (PRM) in many of them, it can be noticed that people-related issues have little weight in the appraisals of the capabilities of organizations while in practice they are considered as significant contributors in traditional process and organizational performance appraisals, as stressed instead in well-known Performance Management models such as MBQA, EFQM and BSC. This paper proposes some ways for leveraging people-related maturity issues merging HR practices from several types of maturity models into the organizational Business Process Model (BPM) in order to achieve higher organizational maturity and capability levels.

  7. Effect of short- and long-term heat stress on the conception risk of dairy cows under natural service and artificial insemination breeding programs.

    Science.gov (United States)

    Schüller, L-K; Burfeind, O; Heuwieser, W

    2016-04-01

    The objectives of this retrospective study were to examine the effect of heat stress on natural service and artificial insemination (AI) breeding methods. We investigated the influence of short- and long-term heat stress on the conception risk (CR) of dairy cows bred by natural service or by AI with frozen-thawed or fresh semen. In addition, the relationship between breeding method and parity was determined. Cows bred by AI with frozen-thawed semen exposed to long-term heat stress (mean temperature-humidity index ≥73 in the period 21d before breeding) were 63% less likely to get pregnant compared with cows not exposed to heat stress. Cows bred by AI with fresh semen were 80% less likely to get pregnant during periods of short-term heat stress than during periods without heat stress. Furthermore, multiparous cows bred by AI with frozen-thawed or fresh semen were 22 and 67% less likely to get pregnant, respectively, than primiparous cows. No influence of heat stress or parity was noted on the CR of cows bred by natural service. The present study indicates that the likelihood of dairy cows becoming pregnant is reduced by short- and long-term heat stress depending on the type of semen employed. In particular, CR of cows inseminated with fresh semen is negatively affected by short-term heat stress and CR of cows inseminated with frozen-thawed semen is negatively affected by long-term heat stress. Copyright © 2016 American Dairy Science Association. Published by Elsevier Inc. All rights reserved.

  8. Concept-Based Curricula: A National Study of Critical Concepts.

    Science.gov (United States)

    Brussow, Jennifer A; Roberts, Karin; Scaruto, Matthew; Sommer, Sheryl; Mills, Christine

    2018-02-22

    As nursing education struggles to address a rapidly changing health care system, overcrowded curricula, and an increased focus on clinical reasoning skills, many programs have adopted or transitioned to concept-based curricula (CBCs), which are structured around key concepts and exemplars. Despite CBC's promised benefits, the process of developing a CBC framework may pose a challenge to programs. To address this barrier, a national study was conducted to develop a representative list of concepts and exemplars. This initiative expands on prior work by suggesting a leveled approach to positioning exemplars within a curricular sequence.This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal.

  9. Diagnostic assessment of skeletal maturity through dental maturation in Hispanic growing individuals

    Directory of Open Access Journals (Sweden)

    Alejandra Cisternas

    2017-01-01

    Full Text Available Background: The aim of this study was to explore dental maturation as a diagnostic test for skeletal maturation. Materials and Methods: Six hundred and fifty-seven growing individuals were classified according to their cervical vertebral maturity and dental maturity, both determined in lateral cephalograms and panoramic radiographs, respectively. The correlation between cervical and dental stages was established for each gender. A receiver operating characteristic curve analysis was made, and sensitivity and specificity values were established. Results: Correlation was found between cervical and dental maturation for females (r = 0.73; P<0.001 and males (r = 0.60; P<0.001. Sensitivity for dental Stage F, as an indicator of a postmaturation peak stage, was 87.21% for females and 97.1% for males, whereas specificity for the same stage was 82.92% and 72.3% for females and males, respectively. Conclusions: Dental maturation evaluation could contribute determining whether a patient is in a pre- or post-growth spurt stage.

  10. Fast mixed spectrum reactor concept

    International Nuclear Information System (INIS)

    Kouts, H.J.C.; Fischer, G.J.; Cerbone, R.J.

    1979-04-01

    The Fast Mixed Spectrum Reactor is a highly promising concept for a fast reactor with improved features of proliferation resistance, and excellent utilization of uranium resources. In technology, it can be considered to be a branch of fast breeder development, though its operation and implications are different from those of FBR'S in important respects. Successful development programs are required in several areas to bring FMSR to reality, but the payoff from a successful program can be high

  11. Growth goals, maturity, and well-being.

    Science.gov (United States)

    Bauer, Jack J; McAdams, Dan P

    2004-01-01

    In 2 studies (125 college students and 51 adults), 2 forms of growth goals (exploratory and intrinsic) were compared with 2 forms of personality development (social-cognitive maturity and social-emotional well-being). Participants whose narratives of major life goals emphasized conceptual exploration were especially likely to have high levels of maturity (measured as ego development; J. Loevinger, 1976), whereas those whose goals emphasized intrinsic interests (K. M. Sheldon & T. Kasser, 1995) were especially likely to have high levels of well-being. Participants who had coherent hierarchies of growth goals on the levels of major life goals and everyday goals were especially likely to have high levels of personality development. Finally, growth goals accounted for some relationships between age and personality development. Growth goals are discussed in terms of intentional self-development and specific developmental paths. (c) 2003 APA

  12. DNA damage response during mouse oocyte maturation

    Czech Academy of Sciences Publication Activity Database

    Mayer, Alexandra; Baran, Vladimír; Sakakibara, Y.; Brzáková, Adéla; Ferencová, Ivana; Motlík, Jan; Kitajima, T.; Schultz, R. M.; Šolc, Petr

    2016-01-01

    Roč. 15, č. 4 (2016), s. 546-558 ISSN 1538-4101 R&D Projects: GA MŠk LH12057; GA MŠk ED2.1.00/03.0124 Institutional support: RVO:67985904 Keywords : double strand DNA breaks * DNA damage * MRE11 * meiotic maturation * mouse oocytes Subject RIV: EB - Genetics ; Molecular Biology Impact factor: 3.530, year: 2016

  13. Regulation of oocyte maturation in fish.

    Science.gov (United States)

    Nagahama, Yoshitaka; Yamashita, Masakane

    2008-06-01

    A period of oocyte growth is followed by a process called oocyte maturation (the resumption of meiosis) which occurs prior to ovulation and is a prerequisite for successful fertilization. Our studies using fish models have revealed that oocyte maturation is a three-step induction process involving gonadotropin (LH), maturation-inducing hormone (MIH), and maturation-promoting factor (MPF). LH acts on the ovarian follicle layer to produce MIH (17alpha, 20beta-dihydroxy-4-pregnen-3-one, 17alpha, 20beta-DP, in most fishes). The interaction of ovarian thecal and granulosa cell layers (two-cell type model), is required for the synthesis of 17alpha,20beta-DP. The dramatic increase in the capacity of postvitellogenic follicles to produce 17alpha,20beta-DP in response to LH is correlated with decreases in P450c17 (P450c17-I) and P450 aromatase (oP450arom) mRNA and increases in the novel form of P450c17 (P450c17-II) and 20beta-hydroxysteroid dehydrogenase (20beta-HSD) mRNA. Transcription factors such as Ad4BP/SF-1, Foxl2, and CREB may be involved in the regulation of expression of these steroidogenic enzymes. A distinct family of G-protein-coupled membrane-bound MIH receptors has been shown to mediate non-genomic actions of 17alpha, 20beta-DP. The MIH signal induces the de novo synthesis of cyclin B from the stored mRNA, which activates a preexisting 35 kDa cdc2 kinase via phosphorylation of its threonine 161 by cyclin-dependent kinase activating kinase, thus producing the 34 kDa active cdc2 (active MPF). Upon egg activation, MPF is inactivated by degradation of cyclin B. This process is initiated by the 26S proteasome through the first cut in its NH(2) terminus at lysine 57.

  14. Measuring interoperability maturity in government networks.

    OpenAIRE

    Huijsman, K.L.L.G.; Plomp, M.G.A.; Batenburg, R.S.

    2012-01-01

    The purpose of this paper is to create a model that describes the development of interorganisational collaboration in government networks that apply eGovernment. Contrary to several models that describe eGovernment from a government-to-citizen perspective, and primarily emphasise on the front office of eGovernment services, this paper focuses on the collaboration that takes place in the back office to enable successful eGovernment services. A maturity model was developed to describe and asses...

  15. MatureBayes: a probabilistic algorithm for identifying the mature miRNA within novel precursors.

    Directory of Open Access Journals (Sweden)

    Katerina Gkirtzou

    Full Text Available BACKGROUND: MicroRNAs (miRNAs are small, single stranded RNAs with a key role in post-transcriptional regulation of thousands of genes across numerous species. While several computational methods are currently available for identifying miRNA genes, accurate prediction of the mature miRNA remains a challenge. Existing approaches fall short in predicting the location of mature miRNAs but also in finding the functional strand(s of miRNA precursors. METHODOLOGY/PRINCIPAL FINDINGS: Here, we present a computational tool that incorporates a Naive Bayes classifier to identify mature miRNA candidates based on sequence and secondary structure information of their miRNA precursors. We take into account both positive (true mature miRNAs and negative (same-size non-mature miRNA sequences examples to optimize sensitivity as well as specificity. Our method can accurately predict the start position of experimentally verified mature miRNAs for both human and mouse, achieving a significantly larger (often double performance accuracy compared with two existing methods. Moreover, the method exhibits a very high generalization performance on miRNAs from two other organisms. More importantly, our method provides direct evidence about the features of miRNA precursors which may determine the location of the mature miRNA. We find that the triplet of positions 7, 8 and 9 from the mature miRNA end towards the closest hairpin have the largest discriminatory power, are relatively conserved in terms of sequence composition (mostly contain a Uracil and are located within or in very close proximity to the hairpin loop, suggesting the existence of a possible recognition site for Dicer and associated proteins. CONCLUSIONS: This work describes a novel algorithm for identifying the start position of mature miRNA(s produced by miRNA precursors. Our tool has significantly better (often double performance than two existing approaches and provides new insights about the potential use

  16. Mature consumers’ relationship with their perfume

    Directory of Open Access Journals (Sweden)

    Lindsey DRYLIE-CAREY

    2018-01-01

    Full Text Available Glamorous and stylish, perfume is an evocative product that provokes a stimulus of the senses. It is suggested that the basis for consumer choice for this product should be based on olfactory preference, however the process related decision-making has been shown to be more complex. The mature consumer purchase decision making in this product category is often associated with long standing, established, luxury fragrance brands. In addition, at the frontline of the perfume sales process are fragrance consultants, who possess invaluable information on consumer involvement with perfume products and brands. Hence, this paper investigates CBR (consumer brand relationship and the subsequent perfume purchase behaviour of mature female consumers from a dual (industry and consumer perspective. Results indicate that important perceptual differences related to brand relationships with perfume exist between fragrance consultants and experts on one hand and consumers on the other. This research promotes a deeper understanding of current consumer approach and issues surrounding female mature purchasing behaviour for this unique category of product, and complements the growing body of literature related to luxury brands.

  17. Towards an energy management maturity model

    International Nuclear Information System (INIS)

    Antunes, Pedro; Carreira, Paulo; Mira da Silva, Miguel

    2014-01-01

    Energy management is becoming a priority as organizations strive to reduce energy costs, conform to regulatory requirements, and improve their corporate image. Despite the upsurge of interest in energy management standards, a gap persists between energy management literature and current implementation practices. This gap can be traced to the lack of an incremental improvement roadmap. In this paper we propose an Energy Management Maturity Model that can be used to guide organizations in their energy management implementation efforts to incrementally achieve compliance with energy management standards such as ISO 50001. The proposed maturity model is inspired on the Plan-Do-Check-Act cycle approach for continual improvement, and covers well-understood fundamental energy management activities common across energy management texts. The completeness of our proposal is then evaluated by establishing an ontology mapping against ISO 50001. - Highlights: • Real-world energy management activities are not aligned with the literature. • An Energy Management Maturity Model is proposed to overcome this alignment gap. • The completeness and relevance of proposed model are validated

  18. Alien Sunset (Artist Concept)

    Science.gov (United States)

    2007-01-01

    Our solitary sunsets here on Earth might not be all that common in the grand scheme of things. New observations from NASA's Spitzer Space Telescope have revealed that mature planetary systems -- dusty disks of asteroids, comets and possibly planets -- are more frequent around close-knit twin, or binary, stars than single stars like our sun. That means sunsets like the one portrayed in this artist's photo concept, and more famously in the movie 'Star Wars,' might be quite commonplace in the universe. Binary and multiple-star systems are about twice as abundant as single-star systems in our galaxy, and, in theory, other galaxies. In a typical binary system, two stars of roughly similar masses twirl around each other like pair-figure skaters. In some systems, the two stars are very far apart and barely interact with each other. In other cases, the stellar twins are intricately linked, whipping around each other quickly due to the force of gravity. Astronomers have discovered dozens of planets that orbit around a single member of a very wide stellar duo. Sunsets from these worlds would look like our own, and the second sun would just look like a bright star in the night sky. But do planets exist in the tighter systems, where two suns would dip below a planet's horizon one by one? Unveiling planets in these systems is tricky, so astronomers used Spitzer to look for disks of swirling planetary debris instead. These disks are made of asteroids, comets and possibly planets. The rocky material in them bangs together and kicks up dust that Spitzer's infrared eyes can see. Our own solar system is swaddled in a similar type of disk. Surprisingly, Spitzer found more debris disks around the tightest binaries it studied (about 20 stars) than in a comparable sample of single stars. About 60 percent of the tight binaries had disks, while the single stars only had about 20 percent. These snug binary systems are as close or closer than just three times the distance between Earth and

  19. Correlation between Cervical Vertebral Maturation Stages and Dental Maturation in a Saudi Sample

    Directory of Open Access Journals (Sweden)

    Nayef H Felemban

    2017-01-01

    Full Text Available Background: The aim of the present study was to compare the cervical vertebra maturation stages method and dental maturity using tooth calcification stages. Methods: The current study comprised of 405 subjects selected from orthodontic patients of Saudi origin coming to clinics of the specialized dental centers in western region of Saudi Arabia. Dental age was assessed according to the developmental stages of upper and lower third molars and skeletal maturation according to the cervical vertebrae maturation stage method. Statistical analysis was done using Kruskal-Wallis H, Mann-Whitney U test, Chi-Square test; t-test and Spearman correlation coefficient for inter group comparison. Results: The females were younger than males in all cervical stages. The CS1-CS2 show the period before the peak of growth, during CS3-CS5 it’s the pubertal growth spurt and CS6 is the period after the peak of the growth. The mean age and standard deviation for cervical stages of CS2, CS3 and CS4 were 12.09 ±1.72 years, 13.19 ±1.62 and 14.88 ±1.52 respectively. The Spearman correlation coefficients between cervical vertebrae and dental maturation were between 0.166 and 0.612, 0.243 and 0.832 for both sexes for upper and lower third molars. The significance levels for all coefficients were equal at 0.01 and 0.05. Conclusion: The results of this study showed that the skeletal maturity increased with the increase in dental ages for both genders. An early rate of skeletal maturation stage was observed in females. This study needs further analysis using a larger sample covering the entire dentition.

  20. Correlation between chronological age, cervical vertebral maturation and Fishman's skeletal maturity indicators in southern Chinese.

    Science.gov (United States)

    Alkhal, Hessa Abdulla; Wong, Ricky W K; Rabie, A Bakr M

    2008-07-01

    To investigate the correlation between chronological age, cervical vertebral maturation (CVM), and Fishman's hand-wrist skeletal maturity indicators in southern Chinese. Four hundred contemporary hand-wrist and lateral cephalometric radiographs of southern Chinese subjects were randomly selected and analyzed. The female subjects were between 10 and 15 years of age, and the male subjects were between 12 and 17 years of age; all subjects were within the circumpubertal period. The CVM was assessed using the method developed by Baccetti and coworkers, but the hand-wrist maturation was assessed using the method developed by Fishman. These two methods and the chronological age were correlated using the Spearman rank correlation analysis. The CVM was significantly correlated with the hand-wrist skeletal age (Spearman r male = 0.9206, female = 0.9363). All patients in the cervical maturation stage (CS3) of CVM were discovered to be in the skeletal maturational indicator (SMI2 or SMI3) stages of hand-wrist maturation (HWM), which was around the peak of the growth spurt. Low correlations were found between the CVM and chronological age (male r = 0.7577; female r = 0.7877) and between the HWM and chronological age (male r = 0.7492; female r = 0.7758). CVM is a valid indicator of skeletal growth during the circumpubertal and has a high correlation with the HWM for the southern Chinese population. However, the low correlations found between the chronological age and both CVM and HWM showed that the chronological age was not suitable to measure skeletal maturity.

  1. Best practices show the way to information security maturity

    CSIR Research Space (South Africa)

    Lessing, MM

    2008-09-01

    Full Text Available A Security Maturity Model (SMM) provides an organisation with a distinct Information Security framework. Organisations that conform to these models are likely to pursue satisfactory Information Security. Additionally, the use of Security Maturity...

  2. A resident's rotation in consultation psychiatry. A maturational experience.

    Science.gov (United States)

    Granet, R B; Perry, S W; Talbott, J A

    1980-12-01

    The authors emphasize the importance of a consultation psychiatry experience in the maturation of the young psychiatrist by examining some of the processes operational in both community and hospital consultation work, performed by the senior author during his fourth year of residency. Such experiences can provide opportunities for developing psychiatric skills not emphasized elsewhere, including the adoption of an active therapeutic stance, the application of the psychodynamic theory to the consultation system itself, and teaching without the use of jargon. In addition the experience as consultant facilitates the transition from residency to the outside world, not only through attitudinal changes achieved by exposure to less structured settings, a change in the supervisory model, and a solidification of identity as a physician and psychiatrist, but also by providing the resident the opportunity to begin de-cathecting from the training program.

  3. Combining ability for maturity and plant height in brassica rapa (l.) ssp. dichotoma (roxb.) hanelt

    International Nuclear Information System (INIS)

    Nasim, A.; Farhatullah, A.; Khan, N.U.; Azam, S.M.; Nasim, Z.

    2014-01-01

    A 5 * 5 F1 diallel cross hybrids of Brassica rapa (L.) ssp. dichotoma (Roxb.) Hanelt along with parents were evaluated through combining ability for days to flowering (initiation and completion), days to maturity and plant height. Highly significant differences were recorded for all the traits. Mean squares due to general, specific and reciprocal combining ability were significant for all the traits except plant height for which the latter two components were non-significant. Prevalence of additive (plant height), non-additive (days to flowering completion; days to maturity) and reciprocal effects (days to flowering initiation) were detected. Parental line G-403 was best general combiner for all the traits. The F1 hybrids G-902 * G-265 (days to flowering initiation), G-902 * G-403 (days to flowering completion), G-265 * G-1500 (days to maturity) and G-909 * G-265 (plant height) were superior and may be exploited for future breeding programs. (author)

  4. Towards a Sustainable Design for Maturity Measurement Marketplace

    DEFF Research Database (Denmark)

    Lasrado, Lester; Vatrapu, Ravi; Kærsgaard, Henrik Bjerre

    2016-01-01

    In this research-in-progress paper, we propose a solution in form of an IT artefact to address both theoretical and practical challenges faced by maturity model designers. We identify and list out the existing challenges & criticisms of maturity models research through an extensive literature...... review, followed by semi-structured interviews with four maturity model designers. We also explore different motivations of building a maturity model, and using them further scope the boundaries of our solution....

  5. Project Icarus: Nuclear Fusion Propulsion Concept Comparison

    Science.gov (United States)

    Stanic, M.

    Project Icarus will use nuclear fusion as the primary propulsion, since achieving breakeven is imminent within the next decade. Therefore, fusion technology provides confidence in further development and fairly high technological maturity by the time the Icarus mission would be plausible. Currently there are numerous (over 2 dozen) different fusion approaches that are simultaneously being developed around the World and it is difficult to predict which of the concepts is going to be the most successful one. This study tried to estimate current technological maturity and possible technological extrapolation of fusion approaches for which appropriate data could be found. Figures of merit that were assessed include: current technological state, mass and volume estimates, possible gain values, main advantages and disadvantages of the concept and an attempt to extrapolate current technological state for the next decade or two. Analysis suggests that Magnetic Confinement Fusion (MCF) concepts are not likely to deliver sufficient performance due to size, mass, gain and large technological barriers of the concept. However, ICF and PJMIF did show potential for delivering necessary performance, assuming appropriate techno- logical advances. This paper is a submission of the Project Icarus Study Group.

  6. Computer Based Assessment of Cervical Vertebral Maturation Stages Using Digital Lateral Cephalograms.

    Science.gov (United States)

    Dzemidzic, Vildana; Sokic, Emir; Tiro, Alisa; Nakas, Enita

    2015-12-01

    This study was aimed to investigate the reliability of a computer application for assessment of the stages of cervical vertebra maturation in order to determine the stage of skeletal maturity. For this study, digital lateral cephalograms of 99 subjects (52 females and 47 males) were examined. The following selection criteria were used during the sample composition: age between 9 and 16 years, absence of anomalies of the vertebrae, good general health, no history of trauma at the cervical region. Subjects with lateral cephalograms of low quality were excluded from the study. For the purpose of this study a computer application Cephalometar HF V1 was developed. This application was used to mark the contours of the second, third and fourth cervical vertebrae on the digital lateral cephalograms, which enabled a computer to determine the stage of cervical vertebral maturation. The assessment of the stages of cervical vertebral maturation was carried out by an experienced orthodontist. The assessment was conducted according to the principles of the method proposed by authors Hassel and Farman. The degree of the agreement between the computer application and the researcher was analyzed using by statistical Cohen Kappa test. The results of this study showed the agreement between the computer assessment and the researcher assessment of the cervical vertebral maturation stages, where the value of the Cohen Kappa coefficient was 0.985. The computer application Cephalometar HF V1 proved to be a reliable method for assessing the stages of cervical vertebral maturation. This program could help the orthodontists to identify the stage of cervical vertebral maturation when planning the orthodontic treatment for the patients with skeletal disharmonies.

  7. Technology Maturation in Preparation for the Cryogenic Propellant Storage and Transfer (CPST) Technology Demonstration Mission (TDM)

    Science.gov (United States)

    Meyer, Michael L.; Doherty, Michael P.; Moder, Jeffrey P.

    2014-01-01

    In support of its goal to find an innovative path for human space exploration, NASA embarked on the Cryogenic Propellant Storage and Transfer (CPST) Project, a Technology Demonstration Mission (TDM) to test and validate key cryogenic capabilities and technologies required for future exploration elements, opening up the architecture for large in-space cryogenic propulsion stages and propellant depots. Recognizing that key Cryogenic Fluid Management (CFM) technologies anticipated for on-orbit (flight) demonstration would benefit from additional maturation to a readiness level appropriate for infusion into the design of the flight demonstration, the NASA Headquarters Space Technology Mission Directorate (STMD) authorized funding for a one-year technology maturation phase of the CPST project. The strategy, proposed by the CPST Project Manager, focused on maturation through modeling, concept studies, and ground tests of the storage and fluid transfer of CFM technology sub-elements and components that were lower than a Technology Readiness Level (TRL) of 5. A technology maturation plan (TMP) was subsequently approved which described: the CFM technologies selected for maturation, the ground testing approach to be used, quantified success criteria of the technologies, hardware and data deliverables, and a deliverable to provide an assessment of the technology readiness after completion of the test, study or modeling activity. The specific technologies selected were grouped into five major categories: thick multilayer insulation, tank applied active thermal control, cryogenic fluid transfer, propellant gauging, and analytical tool development. Based on the success of the technology maturation efforts, the CPST project was approved to proceed to flight system development.

  8. Teachers' conceptions of the nature of science: Analyzing the impact of a teacher enhancement program in changing attitudes and perceptions of science and scientific research

    Science.gov (United States)

    Govett, Aimee Lee

    The purpose of this study was to determine the efficacy of a residential science research experience in changing participants' attitudes and understanding of the nature of science and their view of themselves as science researchers. Data from interviews, journal writings, classroom observations and two pre-post instruments were used in the evaluation plan. As participants of this study, 16 inservice teachers (K--16) attended a two-week residential institute at the National Radio Astronomy Observatory (NRAO) in Green Bank, West Virginia. The format of the institute featured a scientific research experience designed to arm its participants with the skills needed to model their classroom teaching after scientific research. The program included lessons on the fundamentals of radio astronomy, science talks and interactions with practicing scientists, in-depth tours of the NRAO facilities, and pedagogical instruction for implementing research in the classroom. The WVU College of Education staff and the NRAO staff stressed the importance of the nature of the research experience offered to these teachers. In the Education Sessions the WVU science education staff guided participants through the steps required to turn their experience around, in order to develop student research projects for their classrooms. The results from the Research Self Assessment instrument show significant gains for all participants in being more comfortable doing research. For the Nature of Science and Science Teaching instrument there were only three items that showed significant gains for all participants both in understanding the nature of science and in their views on implementing the Green Bank constructivist learning philosophy. The women, especially the elementary teacher group, showed the greatest change in their understanding of the nature of science as reflected in the interviews as well as in their personal journals. The seven men, who were all in the secondary field, made no significant

  9. Induction and inhibition of oocyte maturation by EDCs in zebrafish

    Directory of Open Access Journals (Sweden)

    Tokumoto Mika

    2005-12-01

    Full Text Available Abstract Background Oocyte maturation in lower vertebrates is triggered by maturation-inducing hormone (MIH, which acts on unidentified receptors on the oocyte surface and induces the activation of maturation-promoting factor (MPF in the oocyte cytoplasm. We previously described the induction of oocyte maturation in fish by an endocrine-disrupting chemical (EDC, diethylstilbestrol (DES, a nonsteroidal estrogen. Methods In this study, stimulatory and inhibitory effects of EDCs and natural steroids on oocyte maturation were examined in zebrafish. For effective agents, some details about the mechanism in induction or inhibition of maturation were examined. Possible groups of DES interacting with the MIH receptor are discussed based on relative potency of steroids to induce maturation. Results Among agents tested, tamoxifen (TAM and its metabolite 4-hydroxytamoxifen (4-OHT showed stimulatory activity similar to DES. The time courses of the change in germinal vesicle breakdown and an intracellular molecular event (the synthesis of cyclin B induced by TAM were indistinguishable from those induced by MIH. In contrast, pentachlorophenol (PCP had a potent inhibitory effect on MIH-induced oocyte maturation. PCP inhibited not only MIH-induced maturation but also DES- and TAM-induced maturation. Methoxychlor also inhibited maturation when oocytes were pre-treated with this agent. Conclusion These results suggest that EDCs act as agonists or antagonists in the induction of oocyte maturation in fish.

  10. Detection of optimum maturity of maize using image processing and ...

    African Journals Online (AJOL)

    A CCD camera for image acquisition of the different green colorations of the maize leaves at maturity was used. Different color features were extracted from the image processing system (MATLAB) and used as inputs to the artificial neural network that classify different levels of maturity. Keywords: Maize, Maturity, CCD ...

  11. Effect of melatonin on maturation capacity and fertilization of Nili ...

    African Journals Online (AJOL)

    This study evaluated the effect of melatonin supplementation of in vitro maturation media on in vitro maturation (IVM) and in vitro fertilization (IVF) rate of buffalo oocytes. Cumulus oocytes complexes (COCs) were aspirated from follicles of 2-8 mm diameter. In experiment I, COCs were matured in IVM medium supplemented ...

  12. 7 CFR 1427.174 - Maturity of seed cotton loans.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 10 2010-01-01 2010-01-01 false Maturity of seed cotton loans. 1427.174 Section 1427.174 Agriculture Regulations of the Department of Agriculture (Continued) COMMODITY CREDIT CORPORATION... Maturity of seed cotton loans. Seed cotton loans mature on demand by CCC but no later than May 31 following...

  13. Correlation between cervical vertebral and dental maturity in Iranian subjects.

    Science.gov (United States)

    Heravi, Farzin; Imanimoghaddam, Mahrokh; Rahimi, Hoda

    2011-12-01

    Determination of the skeletal maturation is extremely important in clinical orthodontics. Cervical vertebral maturation is an effective diagnostic tool for determining the adolescent growth spurt. The aim of this study was to investigate the correlation between the stages of calcification of teeth and the cervical vertebral maturity stages.

  14. Conception of a product-related TopRunner pulse program. Supplementary scientific consultancy services: Working out of program modules for the practical implementation; Konzeption eines produktbezogenen TopRunner-Impulsprogramms. Ergaenzende wissenschaftliche Beratungsleistung: Erarbeitung von Programm-Modulen zur praktischen Umsetzung

    Energy Technology Data Exchange (ETDEWEB)

    Grether, Stefanie; Graulich, Kathrin; Griesshammer, Rainer

    2009-11-20

    Top runners - that is, devices with the most efficient advanced technology - are offered by the manufacturers too rare, and are required too little from the consumers. Under this aspect, the project under consideration accompanies scientifically the practical implementation in the preparatory phase of a presumably TopRunner pulse program. In addition, three other objectives are pursued: (1) Development of a product database for top runner products; (2) Construction of a comprehensive power saving brochure for the consumer advice (content and layout); (3) Design of a e-learning concept for power saving advice.

  15. Recent Concepts in Dyslexia: Implications for Diagnosis and Remediation.

    Science.gov (United States)

    Forness, Steven R.

    The report briefly reviews research on the concepts of attention, memory, and linguistic deficits, as well as maturational lag and interactive factors; and considers possible implications for assessment and instruction of reading disabled/dyslexic children. Early theories relating to dyslexia or specific reading disability are traced from S.…

  16. Wireless Roadside Inspection Proof of Concept Test Final Report

    Energy Technology Data Exchange (ETDEWEB)

    Capps, Gary J [ORNL; Franzese, Oscar [ORNL; Knee, Helmut E [ORNL; Plate, Randall S [ORNL; Lascurain, Mary Beth [ORNL

    2009-03-01

    The U.S. Department of Transportation (DOT) FMCSA commissioned the Wireless Roadside Inspection (WRI) Program to validate technologies and methodologies that can improve safety through inspections using wireless technologies that convey real-time identification of commercial vehicles, drivers, and carriers, as well as information about the condition of the vehicles and their drivers. It is hypothesized that these inspections will: -- Increase safety -- Decrease the number of unsafe commercial vehicles on the road; -- Increase efficiency -- Speed up the inspection process, enabling more inspections to occur, at least on par with the number of weight inspections; -- Improve effectiveness -- Reduce the probability of drivers bypassing CMV inspection stations and increase the likelihood that fleets will attempt to meet the safety regulations; and -- Benefit industry -- Reduce fleet costs, provide good return-on-investment, minimize wait times, and level the playing field. The WRI Program is defined in three phases which are: Phase 1: Proof of Concept Test (POC) Testing of commercially available off-the-shelf (COTS) or near-COTS technology to validate the wireless inspection concept. Phase 2: Pilot Test Safety technology maturation and back office system integration Phase 3: Field Operational Test Multi-vehicle testing over a multi-state instrumented corridor This report focuses on Phase 1 efforts that were initiated in March, 2006. Technical efforts dealt with the ability of a Universal Wireless Inspection System (UWIS) to collect driver, vehicle, and carrier information; format a Safety Data Message Set from this information; and wirelessly transmit a Safety Data Message Set to a roadside receiver unit or mobile enforcement vehicle.

  17. Transcriptional maturation of the mouse auditory forebrain.

    Science.gov (United States)

    Hackett, Troy A; Guo, Yan; Clause, Amanda; Hackett, Nicholas J; Garbett, Krassimira; Zhang, Pan; Polley, Daniel B; Mirnics, Karoly

    2015-08-14

    The maturation of the brain involves the coordinated expression of thousands of genes, proteins and regulatory elements over time. In sensory pathways, gene expression profiles are modified by age and sensory experience in a manner that differs between brain regions and cell types. In the auditory system of altricial animals, neuronal activity increases markedly after the opening of the ear canals, initiating events that culminate in the maturation of auditory circuitry in the brain. This window provides a unique opportunity to study how gene expression patterns are modified by the onset of sensory experience through maturity. As a tool for capturing these features, next-generation sequencing of total RNA (RNAseq) has tremendous utility, because the entire transcriptome can be screened to index expression of any gene. To date, whole transcriptome profiles have not been generated for any central auditory structure in any species at any age. In the present study, RNAseq was used to profile two regions of the mouse auditory forebrain (A1, primary auditory cortex; MG, medial geniculate) at key stages of postnatal development (P7, P14, P21, adult) before and after the onset of hearing (~P12). Hierarchical clustering, differential expression, and functional geneset enrichment analyses (GSEA) were used to profile the expression patterns of all genes. Selected genesets related to neurotransmission, developmental plasticity, critical periods and brain structure were highlighted. An accessible repository of the entire dataset was also constructed that permits extraction and screening of all data from the global through single-gene levels. To our knowledge, this is the first whole transcriptome sequencing study of the forebrain of any mammalian sensory system. Although the data are most relevant for the auditory system, they are generally applicable to forebrain structures in the visual and somatosensory systems, as well. The main findings were: (1) Global gene expression

  18. Maturity associated variance in physical activity and health-related quality of life in adolescent females: a mediated effects model.

    Science.gov (United States)

    Smart, Joan E Hunter; Cumming, Sean P; Sherar, Lauren B; Standage, Martyn; Neville, Helen; Malina, Robert M

    2012-01-01

    This study tested a mediated effects model of psychological and behavioral adaptation to puberty within the context of physical activity (PA). Biological maturity status, physical self-concept, PA, and health-related quality of life (HRQoL) were assessed in 222 female British year 7 to 9 pupils (mean age = 12.7 years, SD = .8). Structural equation modeling using maximum likelihood estimation and bootstrapping procedures supported the hypothesized model. Maturation status was inversely related to perceptions of sport competence, body attractiveness, and physical condition; and indirectly and inversely related to physical self-worth, PA, and HRQoL. Examination of the bootstrap-generated bias-corrected confidence intervals representing the direct and indirect paths between suggested that physical self-concept partially mediated the relations between maturity status and PA, and maturity status and HRQoL. Evidence supports the contention that perceptions of the physical self partially mediate relations maturity, PA, and HRQoL in adolescent females.

  19. Effects of posttreatment skeletal maturity measured with the cervical vertebral maturation method on incisor alignment relapse.

    Science.gov (United States)

    Fudalej, Piotr; Rothe, Laura E; Bollen, Anne-Marie

    2008-08-01

    Our aim was to test the hypothesis that relapse of incisor alignment is associated with skeletal maturity at the end of treatment, as assessed with the cervical vertebral maturation (CVM) method. This was a case-control study with information from the postretention database at the University of Washington. Mandibular incisor irregularity (II) at least 10 years out of retention (T3) was used to define the subjects (II >6 mm, relapse group) and the controls (II 0.05). Pretreatment II and postretention time were found to be correlated with long-term incisor stability (P = 0.007 and 0.034, respectively). Sex was not related to relapse (P = 0.33). Maturity of craniofacial structures at the end of treatment evaluated with the CVM method is not associated with long-term stability of incisor alignment.

  20. The Development of Marital Maturity Scale

    Directory of Open Access Journals (Sweden)

    Muhammed YILDIZ

    2017-06-01

    Full Text Available In this study, validity, reliability and item analysis studies of the Marital Maturity Scale prepared to test whether individuals are ready for marriage have been done. Studies of the development of the scale were made on 623 individuals, consisting of single adults. In the validity studies of the scale, explanatory and confirmatory factor analyses and criterion related validity studies were performed. Factor analysis revealed that the scale had four dimensions. The four factors in the measurement account for 60.91% of the total variance. The factor loadings of the items in the scale range from 0.42 to 0.86. Inonu Marriage Attitude Scale was used in the criterion related validity studies. Correlation value of the two scales r=0.72 (p=0.000 was found significant. It was determined that the subscales of the scale had a significant correlation with the total scale. The cronbach alpha value of the first dimension of the scale was 0.85, the cronbach alpha value of the second dimension of the scale was 0.68, the cronbach alpha value of the third dimension of the scale was 0.80, the cronbach alpha value of the fourth dimension of the scale was 0.91 and the cronbach alpha value of the total scale was 0.90. Test retest results r=0.70, (p=0.000 were found significant. In the item analysis studies, it was revealed that in the lower 27% group, the individuals in the upper 27% group were significantly different in all items (p=0.000. The item total correlation value of the items in the scale was between 0.40 and 0.63. As a result of the assessments, it was concluded that the Marital Maturity Scale was a reliable and valid instrument to measure marital maturity of single adults

  1. [Maturation of cerebral somatosensory evoked potentials].

    Science.gov (United States)

    Cadilhac, J; Zhu, Y; Georgesco, M; Echenne, B; Rodiere, M

    1985-07-01

    Cerebral somatosensory evoked potentials (SEPs) were elicited by stimulation of the median nerve and/or posterior tibial nerve in 117 children of 1 day to 16 years old. A major negative wave (N) was consistently recorded from the parietal region of the scalp when the arm was stimulated. The peak latency, the onset latency, the rising time and the duration of H wave are closely correlated with age and body length. The latencies are shortest in the subjects of 1-3 years old. SEPs to lower extremity stimulation were inconstant in the infants before the age of one. The major positive wave (P) has a variable topographic distribution along the middle line, over the scalp. The latencies are also very variable in the different subjects of the same age as well as in the same subject with different locations of active electrode. Among the parameters studied as for N wave, only the rising time of P wave is significantly correlated with age. The latencies of P wave have the shortest value in the subjects of 1-3 years old. The comparison of SEPs to upper and to lower limb stimulations shows that there is no relationship between them in respect to their morphology and amplitude. The minimum value of the latencies of N and P waves was observed at the same age but the difference between the peak latencies of P and N waves in the same subject increases considerably after 2 years of age and reaches the adult value after 5 years of age. These resultats indicate that the maturation of the peripheral somatosensory pathways proceeds at a higher rate than that of the central somatosensory pathways, that the maturation of the somatosensory pathways of the upper limb precedes that of the lower limb, and that the rising time of N or P waves is a good index of cortical maturation. The clinical utility of these SEPs in pediatrics is discussed.

  2. A PACS maturity model: a systematic meta-analytic review on maturation and evolvability of PACS in the hospital enterprise.

    NARCIS (Netherlands)

    Wetering, R. van de; Batenburg, R.

    2009-01-01

    INTRODUCTION: With PACS and medical imaging technology maturing, the importance of organizational maturity and effective deployment of PACS in the hospital enterprise are becoming significant. OBJECTIVE: The objective of this paper is twofold. Firstly, PACS literature on maturity and evolvability in

  3. Digital Marketing Maturity Models: Overview and Comparison

    OpenAIRE

    Elina Bakhtieva

    2017-01-01

    The variety of available digital tools, strategies and activities might confuse and disorient even an experienced marketer. This applies in particular to B2B companies, which are usually less flexible in uptaking of digital technology than B2C companies. B2B companies are lacking a framework that corresponds to the specifics of the B2B business, and which helps to evaluate a company’s capabilities and to choose an appropriate path. A B2B digital marketing maturity model helps to fill this gap...

  4. The Homo Energeticus: maturity, inheritance, identity

    International Nuclear Information System (INIS)

    Mason, Arthur

    2013-01-01

    In this letter, modern society’s intimate bond to the convenience and reliability of delivered energy services results in a form of identification I call the Homo Energeticus. The Homo Energeticus relies upon a mature system of services for achieving an equivalency of status and prestige that is historically similar to the morality of a noble class. I describe the uniqueness of this identity by its imperative for acquiring experience through an invisibility of energy expenditures. In this way, the Homo Energeticus cultivates a highly individualized life whose ambience of perfection, while created personally, is only successful insofar as it conceals energy expenditures in labor and supply. (letter)

  5. Analyzing Project Management Maturity Level in Indonesia

    Directory of Open Access Journals (Sweden)

    Eliot Simangunsong

    2013-05-01

    Full Text Available Normal 0 false false false IN X-NONE X-NONE MicrosoftInternetExplorer4 Project management has been generally known and increasingly used by many organizations to gain competitive advantage. In this context, many studies have proposed maturity models to evaluate how project management knowledge has been deployed effectively and efficiently in organization. As a developing country, Indonesia needs many development projects managed by government and private companies in different industries. Here, a study to assess project management maturity level in Indonesian businesses may bring insight about current business practices, which is important to speed up country development and business sustainability.  Adapting the Project Management Maturity Model (ProMMM, a survey instrument has been developed and applied to professionals from Jakarta and surrounding area.  The result of analysis shows that construction and primary industry have a higher maturity level compare to manufacturing and services.  It is to be noted, however, that the level of project management understanding is low across industries.  This indicates that more quality project management training or certification is required to improve overall project management knowledge in Indonesia. /* Style Definitions */ table.MsoNormalTable {mso-style-name:"Table Normal"; mso-tstyle-rowband-size:0; mso-tstyle-colband-size:0; mso-style-noshow:yes; mso-style-priority:99; mso-style-qformat:yes; mso-style-parent:""; mso-padding-alt:0cm 5.4pt 0cm 5.4pt; mso-para-margin:0cm; mso-para-margin-bottom:.0001pt; mso-pagination:widow-orphan; font-size:11.0pt; font-family:"Calibri","sans-serif"; mso-ascii-font-family:Calibri; mso-ascii-theme-font:minor-latin; mso-fareast-font-family:"Times New Roman"; mso-fareast-theme-font:minor-fareast; mso-hansi-font-family:Calibri; mso-hansi-theme-font:minor-latin; mso-bidi-font-family:"Times New Roman"; mso-bidi-theme-font:minor-bidi;}

  6. Ovarian Mature Cystic Teratoma Containing Multiple Mobile

    Energy Technology Data Exchange (ETDEWEB)

    Cho, Hyun Sun; Yoon, Seong Eon; Lee, Young Hwan; Kim, Hye Won; Yoon, Kwon Ha [Wonkwang University Hospital, Iksan (Korea, Republic of); Park, Seong Hoon [Asan Medical Center, Seoul (Korea, Republic of)

    2006-12-15

    A 48-year-old woman was admitted to our hospital with a palpable mass in her lower abdomen. A left ovarian, cystic mass containing multiple mobile globules was seen on CT and MR images. The outer portion of the globules showed fat components on CT and fat-saturated T1-weighted MR images. Ultrasonography showed multiple echogenic, mobile globules with some sound attenuation and hyper echoic lines and dots within the cystic mass, which corresponded with the presence of lipid globules and hair shafts of ovarian mature cystic teratoma, respectively

  7. Ovarian Mature Cystic Teratoma Containing Multiple Mobile

    International Nuclear Information System (INIS)

    Cho, Hyun Sun; Yoon, Seong Eon; Lee, Young Hwan; Kim, Hye Won; Yoon, Kwon Ha; Park, Seong Hoon

    2006-01-01

    A 48-year-old woman was admitted to our hospital with a palpable mass in her lower abdomen. A left ovarian, cystic mass containing multiple mobile globules was seen on CT and MR images. The outer portion of the globules showed fat components on CT and fat-saturated T1-weighted MR images. Ultrasonography showed multiple echogenic, mobile globules with some sound attenuation and hyper echoic lines and dots within the cystic mass, which corresponded with the presence of lipid globules and hair shafts of ovarian mature cystic teratoma, respectively

  8. Asset Stripping in a Mature Market Economy

    DEFF Research Database (Denmark)

    Klarskov Jeppesen, Kim; Møller, Ulrik Gorm

    2011-01-01

    Purpose – The purpose of this paper is to document a Danish fraud scheme, in which a large number of limited companies were stripped of their assets leaving them with nothing but tax debt, eventually causing the Danish Tax and Customs Administration to lose large sums. Furthermore, the purpose...... indicates that asset stripping may take place in mature market economies to the extent that perpetrators are able to circumvent the corporate governance system by giving lawyers, public accountants and banks incentives to act less critically towards dubious business transactions. Research limitations...

  9. Finding myself: a theory on the maturation of spirituality and its influence on behavior during late adolescence.

    Science.gov (United States)

    Mason, Deanna M

    2014-01-01

    This study employed a grounded theory research design to develop a theoretical model focused on the maturation of spirituality and its influence on behavior during late adolescence. Quantitative research studies have linked spirituality with decreased health-risk behaviors and increased health-promotion behaviors during late adolescence. Qualitative, theoretical data is proposed to discover the underlying reasons this relationship exists and increase the ability to apply this knowledge to practice. Twenty-one adolescents, age 16-21 years, were e-mail interviewed and transcripts analyzed using a conceptual lens of Blumer's symbolic interactionism. From this analysis, a theoretical model emerged with the core concept, finding myself that represents 5 core process concepts. Implications of this study illustrate that late adolescents are aware of their personal spiritual maturation as well as its influence on behavior. In addition, a distinction between the generic concept of spirituality, personal spirituality, and religion emerged.

  10. Defined Engineered Human Myocardium with Advanced Maturation for Applications in Heart Failure Modelling and Repair

    Science.gov (United States)

    Tiburcy, Malte; Hudson, James E.; Balfanz, Paul; Schlick, Susanne; Meyer, Tim; Liao, Mei-Ling Chang; Levent, Elif; Raad, Farah; Zeidler, Sebastian; Wingender, Edgar; Riegler, Johannes; Wang, Mouer; Gold, Joseph D.; Kehat, Izhak; Wettwer, Erich; Ravens, Ursula; Dierickx, Pieterjan; van Laake, Linda W.; Goumans, Marie Jose; Khadjeh, Sara; Toischer, Karl; Hasenfuss, Gerd; Couture, Larry A.; Unger, Andreas; Linke, Wolfgang A.; Araki, Toshiyuki; Neel, Benjamin; Keller, Gordon; Gepstein, Lior; Wu, Joseph C.; Zimmermann, Wolfram-Hubertus

    2017-01-01

    Background Advancing structural and functional maturation of stem cell-derived cardiomyocytes remains a key challenge for applications in disease modelling, drug screening, and heart repair. Here, we sought to advance cardiomyocyte maturation in engineered human myocardium (EHM) towards an adult phenotype under defined conditions. Methods We systematically investigated cell composition, matrix and media conditions to generate EHM from embryonic and induced pluripotent stem cell-derived cardiomyocytes and fibroblasts with organotypic functionality under serum-free conditions. We employed morphological, functional, and transcriptome analyses to benchmark maturation of EHM. Results EHM demonstrated important structural and functional properties of postnatal myocardium, including: (1) rod-shaped cardiomyocytes with M-bands assembled as a functional syncytium; (2) systolic twitch forces at a similar level as observed in bona fide postnatal myocardium; (3) a positive force-frequency-response; (4) inotropic responses to β-adrenergic stimulation mediated via canonical β1- and β2-adrenoceptor signaling pathways; and (5) evidence for advanced molecular maturation by transcriptome profiling. EHM responded to chronic catecholamine toxicity with contractile dysfunction, cardiomyocyte hypertrophy, cardiomyocyte death, and NT-proBNP release; all are classical hallmarks of heart failure. Additionally, we demonstrate scalability of EHM according to anticipated clinical demands for cardiac repair. Conclusions We provide proof-of-concept for a universally applicable technology for the engineering of macro-scale human myocardium for disease modelling and heart repair from embryonic and induced pluripotent stem cell-derived cardiomyocytes under defined, serum-free conditions. PMID:28167635

  11. Defined Engineered Human Myocardium With Advanced Maturation for Applications in Heart Failure Modeling and Repair.

    Science.gov (United States)

    Tiburcy, Malte; Hudson, James E; Balfanz, Paul; Schlick, Susanne; Meyer, Tim; Chang Liao, Mei-Ling; Levent, Elif; Raad, Farah; Zeidler, Sebastian; Wingender, Edgar; Riegler, Johannes; Wang, Mouer; Gold, Joseph D; Kehat, Izhak; Wettwer, Erich; Ravens, Ursula; Dierickx, Pieterjan; van Laake, Linda W; Goumans, Marie Jose; Khadjeh, Sara; Toischer, Karl; Hasenfuss, Gerd; Couture, Larry A; Unger, Andreas; Linke, Wolfgang A; Araki, Toshiyuki; Neel, Benjamin; Keller, Gordon; Gepstein, Lior; Wu, Joseph C; Zimmermann, Wolfram-Hubertus

    2017-05-09

    Advancing structural and functional maturation of stem cell-derived cardiomyocytes remains a key challenge for applications in disease modeling, drug screening, and heart repair. Here, we sought to advance cardiomyocyte maturation in engineered human myocardium (EHM) toward an adult phenotype under defined conditions. We systematically investigated cell composition, matrix, and media conditions to generate EHM from embryonic and induced pluripotent stem cell-derived cardiomyocytes and fibroblasts with organotypic functionality under serum-free conditions. We used morphological, functional, and transcriptome analyses to benchmark maturation of EHM. EHM demonstrated important structural and functional properties of postnatal myocardium, including: (1) rod-shaped cardiomyocytes with M bands assembled as a functional syncytium; (2) systolic twitch forces at a similar level as observed in bona fide postnatal myocardium; (3) a positive force-frequency response; (4) inotropic responses to β-adrenergic stimulation mediated via canonical β 1 - and β 2 -adrenoceptor signaling pathways; and (5) evidence for advanced molecular maturation by transcriptome profiling. EHM responded to chronic catecholamine toxicity with contractile dysfunction, cardiomyocyte hypertrophy, cardiomyocyte death, and N-terminal pro B-type natriuretic peptide release; all are classical hallmarks of heart failure. In addition, we demonstrate the scalability of EHM according to anticipated clinical demands for cardiac repair. We provide proof-of-concept for a universally applicable technology for the engineering of macroscale human myocardium for disease modeling and heart repair from embryonic and induced pluripotent stem cell-derived cardiomyocytes under defined, serum-free conditions. © 2017 American Heart Association, Inc.

  12. A Comparison of Skeletal Maturation assessed from MP3 and Its Correlation with Dental Maturation

    Directory of Open Access Journals (Sweden)

    Vishnu Vardhan Reddy

    2014-01-01

    Full Text Available To compare the various ossification stages of middle phalanges of third finger (MP3 and developmental stages of 2nd mandibular molar during the entire process of pubertal growth spurt. Evaluate the feasibility of recording MP3 stages using standard dental X-ray film. The mandibular 2nd molar exhibited highly significant correlation for both the males and females. This study showed a good correlation between the MP3 and dental maturity indicators. Therefore, 2nd molar tooth could be used as maturity indicator for the entire period of pubertal growth spurt. It can be used as an adjunct to the hand and wrist radiograph.

  13. 7 CFR 273.1 - Household concept.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 4 2010-01-01 2010-01-01 false Household concept. 273.1 Section 273.1 Agriculture Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE FOOD STAMP AND FOOD DISTRIBUTION PROGRAM CERTIFICATION OF ELIGIBLE HOUSEHOLDS § 273.1 Household concept...

  14. Conceptions of Parents, Conceptions of Self, and Conceptions of God.

    Science.gov (United States)

    Buri, John R.; Mueller, Rebecca A.

    Different theorists have suggested that an individual's view of God may be related to one's view of one's father, one's mother, or one's self. A study was conducted to examine the relationship of college students' conceptions of the wrathfulness-kindliness of God to their conceptions of their father's and mother's permissiveness, authoritarianism,…

  15. Advanced microwave processing concepts

    Energy Technology Data Exchange (ETDEWEB)

    Lauf, R.J.; McMillan, A.D.; Paulauskas, F.L. [Oak Ridge National Laboratory, TN (United States)

    1995-05-01

    The purpose of this work is to explore the feasibility of several advanced microwave processing concepts to develop new energy-efficient materials and processes. The project includes two tasks: (1) commercialization of the variable-frequency microwave furnace; and (2) microwave curing of polymer composites. The variable frequency microwave furnace, whose initial conception and design was funded by the AIC Materials Program, will allow us, for the first time, to conduct microwave processing studies over a wide frequency range. This novel design uses a high-power traveling wave tube (TWT) originally developed for electronic warfare. By using this microwave source, one can not only select individual microwave frequencies for particular experiments, but also achieve uniform power densities over a large area by the superposition of many different frequencies. Microwave curing of thermoset resins will be studied because it hold the potential of in-situ curing of continuous-fiber composites for strong, lightweight components. Microwave heating can shorten curing times, provided issues of scaleup, uniformity, and thermal management can be adequately addressed.

  16. Supersonic Retropropulsion Flight Test Concepts

    Science.gov (United States)

    Post, Ethan A.; Dupzyk, Ian C.; Korzun, Ashley M.; Dyakonov, Artem A.; Tanimoto, Rebekah L.; Edquist, Karl T.

    2011-01-01

    NASA's Exploration Technology Development and Demonstration Program has proposed plans for a series of three sub-scale flight tests at Earth for supersonic retropropulsion, a candidate decelerator technology for future, high-mass Mars missions. The first flight test in this series is intended to be a proof-of-concept test, demonstrating successful initiation and operation of supersonic retropropulsion at conditions that replicate the relevant physics of the aerodynamic-propulsive interactions expected in flight. Five sub-scale flight test article concepts, each designed for launch on sounding rockets, have been developed in consideration of this proof-of-concept flight test. Commercial, off-the-shelf components are utilized as much as possible in each concept. The design merits of the concepts are compared along with their predicted performance for a baseline trajectory. The results of a packaging study and performance-based trade studies indicate that a sounding rocket is a viable launch platform for this proof-of-concept test of supersonic retropropulsion.

  17. Exploring Mission Concepts with the JPL Innovation Foundry A-Team

    Science.gov (United States)

    Ziemer, John K.; Ervin, Joan; Lang, Jared

    2013-01-01

    The JPL Innovation Foundry has established a new approach for exploring, developing, and evaluating early concepts called the A-Team. The A-Team combines innovative collaborative methods with subject matter expertise and analysis tools to help mature mission concepts. Science, implementation, and programmatic elements are all considered during an A-Team study. Methods are grouped by Concept Maturity Level (CML), from 1 through 3, including idea generation and capture (CML 1), initial feasibility assessment (CML 2), and trade space exploration (CML 3). Methods used for each CML are presented, and the key team roles are described from two points of view: innovative methods and technical expertise. A-Team roles for providing innovative methods include the facilitator, study lead, and assistant study lead. A-Team roles for providing technical expertise include the architect, lead systems engineer, and integration engineer. In addition to these key roles, each A-Team study is uniquely staffed to match the study topic and scope including subject matter experts, scientists, technologists, flight and instrument systems engineers, and program managers as needed. Advanced analysis and collaborative engineering tools (e.g. cost, science traceability, mission design, knowledge capture, study and analysis support infrastructure) are also under development for use in A-Team studies and will be discussed briefly. The A-Team facilities provide a constructive environment for innovative ideas from all aspects of mission formulation to eliminate isolated studies and come together early in the development cycle when they can provide the biggest impact. This paper provides an overview of the A-Team, its study processes, roles, methods, tools and facilities.

  18. Mediastinal Mature Teratoma Revealed by Empyema

    Directory of Open Access Journals (Sweden)

    Mohammed Raoufi

    2016-01-01

    Full Text Available Teratomas are germ cell tumors, manifested with a great variety of clinical features; the most common extragonadal site is the anterior mediastinum. In this case, we report the patient with a large mature mediastinal teratoma with several components of ectodermal and endothermal epithelium. A 24-year-old female patient presented with history of persistent chest pain and progressively aggravating dyspnea for the previous 3 months. A chest X-ray showed a large opacity of the entire left hemithorax. Transcutaneous needle aspiration revealed a purulent fluid. The tube thoracostomy was introduced and the effusion was evacuated. Some weeks later, patient was seen in emergency for persistent cough and lateral chest pain. CT scan revealed a mass of the left hemithorax. The mass showed heterogeneous density, without compressing mediastinum great vessels and left hilar structures. Lipase value was elevated in needle aspiration. The patient underwent a total resection of the mediastinum mass via a left posterolateral thoracotomy. Microscopy revealed a mature teratoma with cystic structures. The patient subsequently made a full recovery. This case provide benign mediastinal teratoma with total atelectasis of left lung and elevated lipase value in needle transcutaneous aspiration; this event is explained by pancreatic component in the cystic tumor. Total removal of the tumor is adequate treatment for this type of teratoma and the prognosis is excellent.

  19. Pitch perception prior to cortical maturation

    Science.gov (United States)

    Lau, Bonnie K.

    Pitch perception plays an important role in many complex auditory tasks including speech perception, music perception, and sound source segregation. Because of the protracted and extensive development of the human auditory cortex, pitch perception might be expected to mature, at least over the first few months of life. This dissertation investigates complex pitch perception in 3-month-olds, 7-month-olds and adults -- time points when the organization of the auditory pathway is distinctly different. Using an observer-based psychophysical procedure, a series of four studies were conducted to determine whether infants (1) discriminate the pitch of harmonic complex tones, (2) discriminate the pitch of unresolved harmonics, (3) discriminate the pitch of missing fundamental melodies, and (4) have comparable sensitivity to pitch and spectral changes as adult listeners. The stimuli used in these studies were harmonic complex tones, with energy missing at the fundamental frequency. Infants at both three and seven months of age discriminated the pitch of missing fundamental complexes composed of resolved and unresolved harmonics as well as missing fundamental melodies, demonstrating perception of complex pitch by three months of age. More surprisingly, infants in both age groups had lower pitch and spectral discrimination thresholds than adult listeners. Furthermore, no differences in performance on any of the tasks presented were observed between infants at three and seven months of age. These results suggest that subcortical processing is not only sufficient to support pitch perception prior to cortical maturation, but provides adult-like sensitivity to pitch by three months.

  20. DEVELOPMENT OF A MATURITY MODEL FOR TELEMEDICINE#

    Directory of Open Access Journals (Sweden)

    L. Van Dyk

    2012-01-01

    Full Text Available

    ENGLISH ABSTRACT: For more than a decade, the South African National Department of Health (DoH has recognised the potential benefit of information and communication technology (ICT in the delivery of health care to rural areas. Despite generous funding and proven technology, not many telemedicine systems have proved sustainable after the pilot phase. The purpose of this paper is to develop a maturity model that can be implemented to measure and manage the capability of a health system, for use in the delivery of sustainable health care after the pilot phase of a telemedicine project. The validity of the telemedicine maturity model (TMMM is tested within the context of the South African public health sector.

    AFRIKAANSE OPSOMMING: Die Suid Afrikaanse Nasionale Departement van Gesondheid het reeds meer as ’n dekade gelede die voordeel besef wat inligtings- en kommunikasietegnologie kan bied ten opsigte van die lewering van gesondheidsorg in afgeleë gebiede. Ten spyte van ruim befondsing en bewese tegnologie, is daar egter min volgehoue telegeneeskundedienste in die publieke gesondheidstelsel van Suid Afrika. Die doel van hierdie artikel is om ’n volwassenheids-model te ontwikkel wat gebruik kan word om die vermoë van ’n gesondheidstelsel te bepaal en bestuur, ten einde telegeneeskunde loodsprojekte vol te hou. Die geldigheid van hierdie telegeneeskunde volwassenheidsmodel (TMMM is getoets binne konteks van die publieke gesondheidsektor van Suid Afrika.