WorldWideScience

Sample records for matter dm basis

  1. Consequences of DM/antiDM Oscillations for Asymmetric WIMP Dark Matter

    CERN Document Server

    Cirelli, Marco; Servant, Geraldine; Zaharijas, Gabrijela

    2012-01-01

    Assuming the existence of a primordial asymmetry in the dark sector, a scenario usually dubbed Asymmetric Dark Matter (aDM), we study the effect of oscillations between dark matter and its antiparticle on the re-equilibration of the initial asymmetry before freeze-out, which enable efficient annihilations to recouple. We calculate the evolution of the DM relic abundance and show how oscillations re-open the parameter space of aDM models, in particular in the direction of allowing large (WIMP-scale) DM masses. A typical wimp with a mass at the EW scale (\\sim 100 GeV - 1 TeV) presenting a primordial asymmetry of the same order as the baryon asymmetry naturally gets the correct relic abundance if the DM-number-violating Delta(DM) = 2 mass term is in the \\sim meV range. The re-establishment of annihilations implies that constraints from the accumulation of aDM in astrophysical bodies are evaded. On the other hand, the ordinary bounds from BBN, CMB and indirect detection signals on annihilating DM have to be consi...

  2. Asymmetric WIMP Dark Matter in the presence of DM/anti-DM oscillations

    International Nuclear Information System (INIS)

    Zaharijas, G.

    2014-01-01

    The general class of 'Asymmetric Dark Matter (DM)' scenarios assumes the existence of a primordial particle/anti-particle asymmetry in the dark matter sector related to the asymmetry in the baryonic one, as a way to achieve the observed similarity between the baryonic and dark matter energy densities today. Focusing on this framework we study the effect of oscillations between dark matter and its anti-particle on the re-equilibration of the initial asymmetry. We calculate the evolution of the dark matter relic abundance and show how oscillations re-open the parameter space of asymmetric dark matter models, in particular in the direction of allowing large (WIMP-scale) DM masses. We found in particular that a typical WIMP with a mass at the EW scale (about 1 TeV) having a primordial asymmetry of the same order as the baryon asymmetry, naturally gets the correct relic abundance if the δm mass term is in the ∼ meV range. This turns out to be a natural value for fermionic DM arising from the higher dimensional operator H 2 DM 2 /Λ where H is the Higgs field and Λ ∼ M Pl . Finally, we constrain the parameter space in this framework by applying up-to-date bounds from indirect detection signals on annihilating DM

  3. runDM: Running couplings of Dark Matter to the Standard Model

    Science.gov (United States)

    D'Eramo, Francesco; Kavanagh, Bradley J.; Panci, Paolo

    2018-02-01

    runDM calculates the running of the couplings of Dark Matter (DM) to the Standard Model (SM) in simplified models with vector mediators. By specifying the mass of the mediator and the couplings of the mediator to SM fields at high energy, the code can calculate the couplings at low energy, taking into account the mixing of all dimension-6 operators. runDM can also extract the operator coefficients relevant for direct detection, namely low energy couplings to up, down and strange quarks and to protons and neutrons.

  4. PPPC 4 DM secondary: a Poor Particle Physicist Cookbook for secondary radiation from Dark Matter

    Energy Technology Data Exchange (ETDEWEB)

    Buch, Jatan [Institut de Physique Théorique, Université Paris Saclay, CNRS, CEA,F-91191 Gif-sur-Yvette (France); Department of Physics, Indian Institute of Technology,Kharagpur, West Bengal - 721302 (India); Cirelli, Marco; Giesen, Gaëlle; Taoso, Marco [Institut de Physique Théorique, Université Paris Saclay, CNRS, CEA,F-91191 Gif-sur-Yvette (France)

    2015-09-11

    We enlarge the set of recipes and ingredients at disposal of any poor particle physicist eager to cook up signatures from weak-scale Dark Matter models by computing two secondary emissions due to DM particles annihilating or decaying in the galactic halo, namely the radio signals from synchrotron emission and the gamma rays from bremsstrahlung. We consider several magnetic field configurations and propagation scenarios for electrons and positrons. We also provide an improved energy loss function for electrons and positrons in the Galaxy, including synchrotron losses in the different configurations, bremsstrahlung losses, ionization losses and Inverse Compton losses with an updated InterStellar Radiation Field.

  5. PPPC 4 DM secondary: a Poor Particle Physicist Cookbook for secondary radiation from Dark Matter

    Energy Technology Data Exchange (ETDEWEB)

    Buch, Jatan; Cirelli, Marco; Giesen, Gaëlle; Taoso, Marco, E-mail: jbuch.iitkgp@gmail.com, E-mail: marco.cirelli@cea.fr, E-mail: gaelle.giesen@cea.fr, E-mail: marco.taoso@cea.fr [Institut de Physique Théorique, Université Paris Saclay, CNRS, CEA, F-91191 Gif-sur-Yvette (France)

    2015-09-01

    We enlarge the set of recipes and ingredients at disposal of any poor particle physicist eager to cook up signatures from weak-scale Dark Matter models by computing two secondary emissions due to DM particles annihilating or decaying in the galactic halo, namely the radio signals from synchrotron emission and the gamma rays from bremsstrahlung. We consider several magnetic field configurations and propagation scenarios for electrons and positrons. We also provide an improved energy loss function for electrons and positrons in the Galaxy, including synchrotron losses in the different configurations, bremsstrahlung losses, ionization losses and Inverse Compton losses with an updated InterStellar Radiation Field.

  6. PPPC 4 DM secondary: a Poor Particle Physicist Cookbook for secondary radiation from Dark Matter

    International Nuclear Information System (INIS)

    Buch, Jatan; Cirelli, Marco; Giesen, Gaëlle; Taoso, Marco

    2015-01-01

    We enlarge the set of recipes and ingredients at disposal of any poor particle physicist eager to cook up signatures from weak-scale Dark Matter models by computing two secondary emissions due to DM particles annihilating or decaying in the galactic halo, namely the radio signals from synchrotron emission and the gamma rays from bremsstrahlung. We consider several magnetic field configurations and propagation scenarios for electrons and positrons. We also provide an improved energy loss function for electrons and positrons in the Galaxy, including synchrotron losses in the different configurations, bremsstrahlung losses, ionization losses and Inverse Compton losses with an updated InterStellar Radiation Field

  7. PPPC 4 DM ID: a poor particle physicist cookbook for dark matter indirect detection

    Energy Technology Data Exchange (ETDEWEB)

    Cirelli, Marco; Panci, Paolo; Strumia, Alessandro [CERN Theory Division, CH-1211 Geneve (Switzerland); Corcella, Gennaro [Museo Storico della Fisica, Centro Studi e Ricerche E. Fermi, P. del Viminale 1, I-00185 Rome (Italy); Hektor, Andi; Kadastik, Mario; Raidal, Martti [National Institute of Chemical Physics and Biophysics, Ravala 10, 10143 Tallinn (Estonia); Hütsi, Gert [Tartu Observatory, Tõravere 61602 (Estonia); Sala, Filippo, E-mail: marco.cirelli@cea.fr [Scuola Normale Superiore, Piazza dei Cavalieri 7, I-56126 Pisa (Italy)

    2011-03-01

    We provide ingredients and recipes for computing signals of TeV-scale Dark Matter annihilations and decays in the Galaxy and beyond. For each DM channel, we present the energy spectra at production, computed by high-statistics simulations. We estimate the Monte Carlo uncertainty by comparing the results yielded by the Pythia and Herwig event generators. We then provide the propagation functions for charged particles in the Galaxy, for several DM distribution profiles and sets of propagation parameters. Propagation of e{sup ±} is performed with an improved semi-analytic method that takes into account position-dependent energy losses in the Milky Way. Using such propagation functions, we compute the energy spectra of e{sup ±}, p-bar and d-bar at the location of the Earth. We then present the gamma ray fluxes, both from prompt emission and from Inverse Compton scattering in the galactic halo. Finally, we provide the spectra of extragalactic gamma rays. All results are available in numerical form and ready to be consumed.

  8. PPPC 4 DM ID: a poor particle physicist cookbook for dark matter indirect detection

    International Nuclear Information System (INIS)

    Cirelli, Marco; Panci, Paolo; Strumia, Alessandro; Corcella, Gennaro; Hektor, Andi; Kadastik, Mario; Raidal, Martti; Hütsi, Gert; Sala, Filippo

    2011-01-01

    We provide ingredients and recipes for computing signals of TeV-scale Dark Matter annihilations and decays in the Galaxy and beyond. For each DM channel, we present the energy spectra at production, computed by high-statistics simulations. We estimate the Monte Carlo uncertainty by comparing the results yielded by the Pythia and Herwig event generators. We then provide the propagation functions for charged particles in the Galaxy, for several DM distribution profiles and sets of propagation parameters. Propagation of e ± is performed with an improved semi-analytic method that takes into account position-dependent energy losses in the Milky Way. Using such propagation functions, we compute the energy spectra of e ± , p-bar and d-bar at the location of the Earth. We then present the gamma ray fluxes, both from prompt emission and from Inverse Compton scattering in the galactic halo. Finally, we provide the spectra of extragalactic gamma rays. All results are available in numerical form and ready to be consumed

  9. The prefabricated building risk decision research of DM technology on the basis of Rough Set

    Science.gov (United States)

    Guo, Z. L.; Zhang, W. B.; Ma, L. H.

    2017-08-01

    With the resources crises and more serious pollution, the green building has been strongly advocated by most countries and become a new building style in the construction field. Compared with traditional building, the prefabricated building has its own irreplaceable advantages but is influenced by many uncertainties. So far, a majority of scholars have been studying based on qualitative researches from all of the word. This paper profoundly expounds its significance about the prefabricated building. On the premise of the existing research methods, combined with rough set theory, this paper redefines the factors which affect the prefabricated building risk. Moreover, it quantifies risk factors and establish an expert knowledge base through assessing. And then reduced risk factors about the redundant attributes and attribute values, finally form the simplest decision rule. This simplest decision rule, which is based on the DM technology of rough set theory, provides prefabricated building with a controllable new decision-making method.

  10. First search for a dark matter annual modulation signal with NaI(Tl) in the Southern Hemisphere by DM-Ice17

    Energy Technology Data Exchange (ETDEWEB)

    Barbosa de Souza, E.; Cherwinka, J.; Cole, A.; Ezeribe, A. C.; Grant, D.; Halzen, F.; Heeger, K. M.; Hsu, L.; Hubbard, A. J. F.; Jo, J. H.; Karle, A.; Kauer, M.; Kudryavtsev, V. A.; Lim, K. E.; Macdonald, C.; Maruyama, R. H.; Mouton, F.; Paling, S. M.; Pettus, W.; Pierpoint, Z. P.; Reilly, B. N.; Robinson, M.; Rogers, F. R.; Sandstrom, P.; Scarff, A.; Spooner, N. J. C.; Telfer, S.; Yang, L.

    2017-02-28

    The first search for a dark matter annual modulation signal with NaI(Tl) target material in the Southern Hemisphere conducted with the DM-Ice17 experiment is presented. DM-Ice17 consists of 17 kg of NaI(Tl) scintillating crystal under 2200 m.w.e. overburden of Antarctic glacial ice. The analysis presented here utilizes a 60.8 kg yr exposure. While unable to exclude the signal reported by DAMA/LIBRA, the DM-Ice17 data are consistent with no modulation in the energy range of 4-20 keV, providing the strongest limits on WIMP candidates from a direct detection experiment located in the Southern Hemisphere. Additionally, the successful deployment and stable operation of 17 kg of NaI(Tl) crystal over 3.5 years establishes the South Pole ice as a viable location for future underground, low-background experiments.

  11. The ArDM experiment

    CERN Document Server

    Haranczyk, M; Badertscher, A; Boccone, V; Bourgeois, N; Bueno, A; Carmona-Benitez, M C; Chorowski, M; Creus, W; Curioni, A; Daw, E; Degunda, U; Dell'Antone, A; Droge, M; Epprecht, L; Haller, C; Horikawa, S; Kaufmann, L; Kisiel, J; Knecht, L; Laffranchi, M; Lagoda, J; Lazzaro, C; Lightfoot, P; Lozano, J; Lussi, D; Maire, G; Mania, S; Marchionni, A; Mavrokoridis, K; Melgarejo, A; Mijakowski, P; Natterer, G; Navas-Concha, S; Otiougova, P; Piotrowska, A; Polinski, J; de Prado, M; Przewlocki, P; Ravat, S; Regenfus, C; Resnati, F; Robinson, M; Rochet, J; Romero, L; Rondio, E; Rubbia, A; Scotto-Lavina, L; Spooner, N; Viant, T; Trawinski, A; Ulbricht, J; Zalewska, A

    2010-01-01

    The aim of the ArDM project is the development and operation of a one ton double-phase liquid argon detector for direct Dark Matter searches. The detector measures both the scintillation light and the ionization charge from ionizing radiation using two independent readout systems. This paper briefly describes the detector concept and presents preliminary results from the ArDM R&D program, including a 3 l prototype developed to test the charge readout system.

  12. Consequences of DM/antiDM oscillations for asymmetric WIMP darkmatter

    DEFF Research Database (Denmark)

    Cirelli, M.; Panci, P.; Servant, G.

    2012-01-01

    Assuming the existence of a primordial asymmetry in the dark sector, a scenario usually dubbed Asymmetric Dark Matter (aDM), we study the effect of oscillations between dark matter and its antiparticle on the re-equilibration of the initial asymmetry before freeze-out, which enable efficient...... a primordial asymmetry of the same order as the baryon asymmetry naturally gets the correct relic abundance if the DM-number-violating Delta(DM) = 2 mass term is in the similar to meV range. The re-establishment of annihilations implies that constraints from the accumulation of aDM in astrophysical bodies...

  13. Coupled DM Heating in SCDEW Cosmologies

    Directory of Open Access Journals (Sweden)

    Silvio Bonometto

    2017-08-01

    Full Text Available Strongly-Coupled Dark Energy plus Warm dark matter (SCDEW cosmologies admit the stationary presence of ∼1% of coupled-DM and DE, since inflationary reheating. Coupled-DM fluctuations therefore grow up to non-linearity even in the early radiative expansion. Such early non-linear stages are modelized here through the evolution of a top-hat density enhancement, reaching an early virial balance when the coupled-DM density contrast is just 25–26, and the DM density enhancement is ∼10 % of the total density. During the time needed to settle in virial equilibrium, the virial balance conditions, however, continue to modify, so that “virialized” lumps undergo a complete evaporation. Here, we outline that DM particles processed by overdensities preserve a fraction of their virial momentum. Although fully non-relativistic, the resulting velocities (moderately affect the fluctuation dynamics over greater scales, entering the horizon later on.

  14. S-pairing in neutron matter: I. Correlated basis function theory

    International Nuclear Information System (INIS)

    Fabrocini, Adelchi; Fantoni, Stefano; Illarionov, Alexey Yu.; Schmidt, Kevin E.

    2008-01-01

    S-wave pairing in neutron matter is studied within an extension of correlated basis function (CBF) theory to include the strong, short range spatial correlations due to realistic nuclear forces and the pairing correlations of the Bardeen, Cooper and Schrieffer (BCS) approach. The correlation operator contains central as well as tensor components. The correlated BCS scheme of [S. Fantoni, Nucl. Phys. A 363 (1981) 381], developed for simple scalar correlations, is generalized to this more realistic case. The energy of the correlated pair condensed phase of neutron matter is evaluated at the two-body order of the cluster expansion, but considering the one-body density and the corresponding energy vertex corrections at the first order of the Power Series expansion. Based on these approximations, we have derived a system of Euler equations for the correlation factors and for the BCS amplitudes, resulting in correlated nonlinear gap equations, formally close to the standard BCS ones. These equations have been solved for the momentum independent part of several realistic potentials (Reid, Argonne v 14 and Argonne v 8 ' ) to stress the role of the tensor correlations and of the many-body effects. Simple Jastrow correlations and/or the lack of the density corrections enhance the gap with respect to uncorrelated BCS, whereas it is reduced according to the strength of the tensor interaction and following the inclusion of many-body contributions

  15. Search for Higgs portal DM at the ILC

    Energy Technology Data Exchange (ETDEWEB)

    Ko, P. [School of Physics, KIAS,Seoul 02455 (Korea, Republic of); Quantum Universe Center, KIAS,Seoul 02455 (Korea, Republic of); Yokoya, Hiroshi [Quantum Universe Center, KIAS,Seoul 02455 (Korea, Republic of)

    2016-08-18

    Higgs portal dark matter (DM) models are simple interesting and viable DM models. There are three types of the models depending on the DM spin: scalar, fermion and vector DM models. In this paper, we consider renormalizable, unitary and gauge invariant Higgs portal DM models, and study how large parameter regions can be surveyed at the International Linear Collider (ILC) experiment at √s=500 GeV. For the Higgs portal singlet fermion and vector DM cases, the force mediator involves two scalar propagators, the SM-like Higgs boson and the dark Higgs boson. We show that their interference generates interesting and important patterns in the mono-Z plus missing E{sub T} signatures at the ILC, and the results are completely different from those obtained from the Higgs portal DM models within the effective field theories. In addition, we show that it would be possible to distinguish the spin of DM in the Higgs portal scenarios, if the shape of the recoil-mass distribution is observed. We emphasize that the interplay between these collider observations and those in the direct detection experiments has to be performed in the model with renomalizability and unitarity to combine the model analyses in different scales.

  16. DM Considerations for Deep Drilling

    OpenAIRE

    Dubois-Felsmann, Gregory

    2016-01-01

    An outline of the current situation regarding the DM plans for the Deep Drilling surveys and an invitation to the community to provide feedback on what they would like to see included in the data processing and visualization of these surveys.

  17. 12 billion DM for Germany

    International Nuclear Information System (INIS)

    Anon.

    1975-01-01

    The German atomic industry has achieved the break-through to the world market: Brazil orders eight nuclear electricity generating plants from Siemens-AEG daughter Kraftwerk-Union. US concerns attacked the twelve billion DM deal, the biggest export order in the history of German industry. Without avail - the contract is to be signed in Bonn this week. (orig./LH) [de

  18. Relationship between particulate matter and childhood asthma - basis of a future warning system for central Phoenix

    Science.gov (United States)

    Dimitrova, R.; Lurponglukana, N.; Fernando, H. J. S.; Runger, G. C.; Hyde, P.; Hedquist, B. C.; Anderson, J.; Bannister, W.; Johnson, W.

    2012-03-01

    Statistically significant correlations between increase of asthma attacks in children and elevated concentrations of particulate matter of diameter 10 microns and less (PM10) were determined for metropolitan Phoenix, Arizona. Interpolated concentrations from a five-site network provided spatial distribution of PM10 that was mapped onto census tracts with population health records. The case-crossover statistical method was applied to determine the relationship between PM10 concentration and asthma attacks. For children ages 5-17, a significant relationship was discovered between the two, while children ages 0-4 exhibited virtually no relationship. The risk of adverse health effects was expressed as a function of the change from the 25th to 75th percentiles of mean level PM10 (36 μg m-3). This increase in concentration was associated with a 12.6% (95% CI: 5.8%, 19.4%) increase in the log odds of asthma attacks among children ages 5-17. Neither gender nor other demographic variables were significant. The results are being used to develop an asthma early warning system for the study area.

  19. How do stars affect ψDM halos?

    Science.gov (United States)

    Chan, James H. H.; Schive, Hsi-Yu; Woo, Tak-Pong; Chiueh, Tzihong

    2018-04-01

    Wave dark matterDM) predicts a compact soliton core and a granular halo in every galaxy. This work presents the first simulation study of an elliptical galaxy by including both stars and ψDM, focusing on the systematic changes of the central soliton and halo granules. With the addition of stars in the inner halo, we find the soliton core consistently becomes more prominent by absorbing mass from the host halo than that without stars, and the halo granules become "non-isothermal", "hotter" in the inner halo and "cooler" in the outer halo, as opposed to the isothermal halo in pure ψDM cosmological simulations. Moreover, the composite (star+ψDM) mass density is found to follow a r-2 isothermal profile near the half-light radius in most cases. Most striking is the velocity dispersion of halo stars that increases rapidly toward the galactic center by a factor of at least 2 inside the half-light radius caused by the deepened soliton gravitational potential, a result that compares favorably with observations of elliptical galaxies and bulges in spiral galaxies. However in some rare situations we find a phase segregation turning a compact distribution of stars into two distinct populations with high and very low velocity dispersions; while the high-velocity component mostly resides in the halo, the very low-velocity component is bound to the interior of the soliton core, resembling stars in faint dwarf spheroidal galaxies.

  20. RESPON DAN KOPING PASIEN DM POST AMPUTASI

    Directory of Open Access Journals (Sweden)

    Candra Kusuma Negara

    2017-09-01

    Full Text Available Penyakit DM merupakan masalah kesehatan yang sangat penting karena berkaitan dengan tingginya kejadian komplikasi dan mortalitas yang tinggi. Bagi kebanyakan orang penyakit DM adalah suatu penyakit yang sangat mengkhawatirkan dan masyarakat sadar akan besarnya potensi bahaya yang ditimbulkannya. Bagi individu yang menderita DM dengan pasca amputasi, kehidupan selanjutnya merupakan babak baru yang penuh tantangan dan perubahan serta akan melalui proses koping terhadap proses perubahan tersebut. Secara umum penelitian ini bertujuan untuk mengeksplorasi berbagai pengalaman pasien DM pasca amputasi tentang respon dan koping yang dialaminya. Penelitian ini menggunakan studi fenomenologi. Pengambilan data menggunakan indepth interview pada empat orang partisipan yang dirawat jalan di Poli kaki diabetic RSUD Ulin Banjarmasin yang dilengkapi dengan pedoman wawancara dan informed consent. Metode analisis yang terstruktur dari Creswell menjadi 6 langkah. Terdapat 2 Tema yang ditemukan dalam penelitian ini yaitu berbagai respon post amputasi dan Berbagai koping pasien DM post amputasi. Berbagai respon post amputasi terdiri dari tiga Sub-Tema yaitu: (1 Mengalami hambatan fisik, (2 Mengalami perubahan peran, (3 Mengalami proses berduka, dan Terdapat empat Sub-Tema yang menggambarkan berbagai koping pasien DM post amputasi yaitu: (1 Lebih banyak beribadah, (2 Menerima keadaan, (3 Motivasi yang kuat, (4 Mencari dukungan sosial.

  1. Studying the physical basis of global warming: thermal effects of the interaction between radiation and matter and greenhouse effect

    International Nuclear Information System (INIS)

    Besson, Ugo; De Ambrosis, Anna; Mascheretti, Paolo

    2010-01-01

    We present a teaching module dealing with the thermal effects of interaction between radiation and matter, the infrared emission of bodies and the greenhouse effect devoted to university level and teacher education. The module stresses the dependence of the optical properties of materials (transparency, absorptivity and emissivity) on radiation frequency, as a result of interaction between matter and radiation. Multiple experiences are suggested to favour a progressive construction of knowledge on the physical aspects necessary to understand the greenhouse effect and global warming. Some results obtained with university students are briefly reported.

  2. Studying the physical basis of global warming: thermal effects of the interaction between radiation and matter and greenhouse effect

    Energy Technology Data Exchange (ETDEWEB)

    Besson, Ugo; De Ambrosis, Anna; Mascheretti, Paolo [Department of Physics ' A Volta' , University of Pavia, Via A Bassi 6, 27100 Pavia (Italy)], E-mail: ugo.besson@unipv.it, E-mail: anna.deambrosisvigna@unipv.it

    2010-03-15

    We present a teaching module dealing with the thermal effects of interaction between radiation and matter, the infrared emission of bodies and the greenhouse effect devoted to university level and teacher education. The module stresses the dependence of the optical properties of materials (transparency, absorptivity and emissivity) on radiation frequency, as a result of interaction between matter and radiation. Multiple experiences are suggested to favour a progressive construction of knowledge on the physical aspects necessary to understand the greenhouse effect and global warming. Some results obtained with university students are briefly reported.

  3. Studying the Physical Basis of Global Warming: Thermal Effects of the Interaction between Radiation and Matter and Greenhouse Effect

    Science.gov (United States)

    Besson, Ugo; De Ambrosis, Anna; Mascheretti, Paolo

    2010-01-01

    We present a teaching module dealing with the thermal effects of interaction between radiation and matter, the infrared emission of bodies and the greenhouse effect devoted to university level and teacher education. The module stresses the dependence of the optical properties of materials (transparency, absorptivity and emissivity) on radiation…

  4. arXiv Dark Matter Effects On Neutron Star Properties

    CERN Document Server

    Ellis, John; Kannike, Kristjan; Marzola, Luca; Raidal, Martti; Vaskonen, Ville

    2018-06-14

    We study possible effects of a dark matter (DM) core on the maximum mass of a neutron star (NS), on the mass-radius relation and on the NS tidal deformability parameter $\\Lambda$. We show that all these quantities would in general be reduced in the presence of a DM core. In particular, our calculations indicate that the presence of a DM core with a mass fraction $\\sim 5\\%$ could affect significantly the interpretation of these NS data as constraints on the nuclear equation of state (EOS), potentially excluding some EOS models on the basis of the measured mass of PSR J0348+0432, while allowing other EOS models to become consistent with the LIGO/Virgo upper limit on $\\Lambda$. Specific scenarios for generating such DM cores are explored in an Appendix.

  5. Complementarity of DM searches in a consistent simplified model: the case of Z′

    International Nuclear Information System (INIS)

    Jacques, Thomas; Katz, Andrey; Morgante, Enrico; Racco, Davide; Rameez, Mohamed; Riotto, Antonio

    2016-01-01

    We analyze the constraints from direct and indirect detection on fermionic Majorana Dark Matter (DM). Because the interaction with the Standard Model (SM) particles is spin-dependent, a priori the constraints that one gets from neutrino telescopes, the LHC, direct and indirect detection experiments are comparable. We study the complementarity of these searches in a particular example, in which a heavy Z ′ mediates the interactions between the SM and the DM. We find that for heavy dark matter indirect detection provides the strongest bounds on this scenario, while IceCube bounds are typically stronger than those from direct detection. The LHC constraints are dominant for smaller dark matter masses. These light masses are less motivated by thermal relic abundance considerations. We show that the dominant annihilation channels of the light DM in the Sun and the Galactic Center are either bb̄ or tt̄, while the heavy DM annihilation is completely dominated by Zh channel. The latter produces a hard neutrino spectrum which has not been previously analyzed. We study the neutrino spectrum yielded by DM and recast IceCube constraints to allow proper comparison with constraints from direct and indirect detection experiments and LHC exclusions.

  6. Template Composite Dark Matter

    DEFF Research Database (Denmark)

    Drach, Vincent; Hietanen, Ari; Pica, Claudio

    2015-01-01

    We present a non perturbative study of SU(2) gauge theory with two fundamental Dirac flavours. We discuss how the model can be used as a template for composite Dark Matter (DM). We estimate one particular interaction of the DM candidate with the Standard Model : the interaction through photon...

  7. Complementarity of DM Searches in a Consistent Simplified Model: the Case of Z'

    CERN Document Server

    Jacques, Thomas; Morgante, Enrico; Racco, Davide; Rameez, Mohamed; Riotto, Antonio

    2016-01-01

    We analyze the constraints from direct and indirect detection on fermionic Majorana Dark Matter (DM). Because the interaction with the Standard Model (SM) particles is spin-dependent, a priori the constraints that one gets from neutrino telescopes, the LHC and direct detection experiments are comparable. We study the complementarity of these searches in a particular example, in which a heavy $Z'$ mediates the interactions between the SM and the DM. We find that in most cases IceCube provides the strongest bounds on this scenario, while the LHC constraints are only meaningful for smaller dark matter masses. These light masses are less motivated by thermal relic abundance considerations. We show that the dominant annihilation channels of the light DM in the Sun are either $b \\bar b$ or $t \\bar t$, while the heavy DM annihilation is completely dominated by $Zh$ channel. The latter produces a hard neutrino spectrum which has not been previously analyzed. We study the neutrino spectrum yielded by DM and recast Ice...

  8. Relationship between rumen protozoal growth, intake of DM, TDN, N, DOM and VFA production rate in buffalo calves

    International Nuclear Information System (INIS)

    Verma, D.N.; Singh, U.B.

    1981-01-01

    Relationships between in vivo rumen protozoal growth and intakes of dry matter (DM), nitrogen, digestible organic matter (DOM), total digestible nutrients (TDN) and volatile fatty acid (VFA) production have been studied. Isotope dilution technique and 14 C-labelled rumen protozoa were used in the studies. (author)

  9. Dynamics of the diffusive DM-DE interaction – Dynamical system approach

    Energy Technology Data Exchange (ETDEWEB)

    Haba, Zbigniew [Institute of Theoretical Physics, University of Wroclaw, Plac Maxa Borna 9, 50-204 Wrocław (Poland); Stachowski, Aleksander; Szydłowski, Marek, E-mail: zhab@ift.uni.wroc.pl, E-mail: aleksander.stachowski@uj.edu.pl, E-mail: marek.szydlowski@uj.edu.pl [Astronomical Observatory, Jagiellonian University, Orla 171, 30-244 Krakow (Poland)

    2016-07-01

    We discuss dynamics of a model of an energy transfer between dark energy (DE) and dark matter (DM) . The energy transfer is determined by a non-conservation law resulting from a diffusion of dark matter in an environment of dark energy. The relativistic invariance defines the diffusion in a unique way. The system can contain baryonic matter and radiation which do not interact with the dark sector. We treat the Friedman equation and the conservation laws as a closed dynamical system. The dynamics of the model is examined using the dynamical systems methods for demonstration how solutions depend on initial conditions. We also fit the model parameters using astronomical observation: SNIa, H ( z ), BAO and Alcock-Paczynski test. We show that the model with diffuse DM-DE is consistent with the data.

  10. Cytokines, Type 2 DM and the Metabolic Syndrome | Ogbera ...

    African Journals Online (AJOL)

    comparable in the DM subjects with and without the Mets and also comparable in obese DM and non obese DM subjects. Of the Mets defining criteria, waist circumference (WC) and Triglyceride (TG) were found to be significantly associated with only two of the studied cytokines. The correlation coefficient and p values of ...

  11. Dark Matter "Collider" from Inelastic Boosted Dark Matter.

    Science.gov (United States)

    Kim, Doojin; Park, Jong-Chul; Shin, Seodong

    2017-10-20

    We propose a novel dark matter (DM) detection strategy for models with a nonminimal dark sector. The main ingredients in the underlying DM scenario are a boosted DM particle and a heavier dark sector state. The relativistic DM impinged on target material scatters off inelastically to the heavier state, which subsequently decays into DM along with lighter states including visible (standard model) particles. The expected signal event, therefore, accompanies a visible signature by the secondary cascade process associated with a recoiling of the target particle, differing from the typical neutrino signal not involving the secondary signature. We then discuss various kinematic features followed by DM detection prospects at large-volume neutrino detectors with a model framework where a dark gauge boson is the mediator between the standard model particles and DM.

  12. Consumenten en hun voorkeuren: een DM toepassing.

    NARCIS (Netherlands)

    PhD Bob van Limburg

    1997-01-01

    In dit artikel een toepassing van een segmentatietechniek die gebruikt kan worden binnen Direct Marketing of liever Interactieve Marketing. Door middel van selectie van profielen op basis van consumentenvoorkeuren kan een database geaggregeerd worden en kan er één op één marketing worden bedreven.

  13. Asymptotically Safe Dark Matter

    DEFF Research Database (Denmark)

    Sannino, Francesco; Shoemaker, Ian M.

    2015-01-01

    We introduce a new paradigm for dark matter (DM) interactions in which the interaction strength is asymptotically safe. In models of this type, the coupling strength is small at low energies but increases at higher energies, and asymptotically approaches a finite constant value. The resulting...... searches are the primary ways to constrain or discover asymptotically safe dark matter....

  14. Possible constraints on SUSY-model parameters from direct dark matter search

    International Nuclear Information System (INIS)

    Bednyakov, V.A.; Kovalenko, S.G.

    1993-01-01

    We consider the SUSY-model neutralino as a dominant Dark Matter particle in the galactic halo and investigate some general issues of direct DM searches via elastic neutralino-nucleus scattering. On the basis of conventional assumptions about the nuclear and nucleon structure, without referring to a specific SUSY-model, we prove that it is impossible in principle to extract more than three constrains on fundamental SUSY-model parameters from the direct Dark Matter searches. Three types of Dark Matter detector probing different groups of parameters are recognized. 21 refs., 1 tab

  15. Laser Boost of a Small Interstellar Ram Jet to Obtain Operational Velocity. Implications for the DM Rocket/Ram Jet Model

    Science.gov (United States)

    Walcott Beckwith, Andrew

    2010-05-01

    In other conference research papers, Beckwith obtained a maximum DM mass/energy value of up to 5 TeV, as opposed to 400 GeV for DM, which may mean more convertible power for a dark matter ram jet. The consequences are from assuming that axions are CDM, and KK gravitons are for WDM, then ρWarm-Dark-Matter would dominate not only structure formation in early universe formation, but would also influence the viability of the DM ram jet applications for interstellar travel. The increase in convertible DM mass makes the ram jet a conceivable option. This paper in addition to describing the scientific issues leading to that 5 TeV mass for DM also what are necessary and sufficient laser boost systems which would permit a ram net to become operational.

  16. Imperfect Dark Matter

    Energy Technology Data Exchange (ETDEWEB)

    Mirzagholi, Leila; Vikman, Alexander, E-mail: l.mirzagholi@physik.uni-muenchen.de, E-mail: alexander.vikman@lmu.de [Arnold Sommerfeld Center for Theoretical Physics, Ludwig Maximilian University Munich, Theresienstr. 37, Munich, D-80333 Germany (Germany)

    2015-06-01

    We consider cosmology of the recently introduced mimetic matter with higher derivatives (HD). Without HD this system describes irrotational dust—Dark Matter (DM) as we see it on cosmologically large scales. DM particles correspond to the shift-charges—Noether charges of the shifts in the field space. Higher derivative corrections usually describe a deviation from the thermodynamical equilibrium in the relativistic hydrodynamics. Thus we show that mimetic matter with HD corresponds to an imperfect DM which: i) renormalises the Newton's constant in the Friedmann equations, ii) has zero pressure when there is no extra matter in the universe, iii) survives the inflationary expansion which puts the system on a dynamical attractor with a vanishing shift-charge, iv) perfectly tracks any external matter on this attractor, v) can become the main (and possibly the only) source of DM, provided the shift-symmetry in the HD terms is broken during some small time interval in the radiation domination époque. In the second part of the paper we present a hydrodynamical description of general anisotropic and inhomogeneous configurations of the system. This imperfect mimetic fluid has an energy flow in the field's rest frame. We find that in the Eckart and in the Landau-Lifshitz frames the mimetic fluid possesses nonvanishing vorticity appearing already at the first order in the HD. Thus, the structure formation and gravitational collapse should proceed in a rather different fashion from the simple irrotational DM models.

  17. Imperfect Dark Matter

    International Nuclear Information System (INIS)

    Mirzagholi, Leila; Vikman, Alexander

    2015-01-01

    We consider cosmology of the recently introduced mimetic matter with higher derivatives (HD). Without HD this system describes irrotational dust—Dark Matter (DM) as we see it on cosmologically large scales. DM particles correspond to the shift-charges—Noether charges of the shifts in the field space. Higher derivative corrections usually describe a deviation from the thermodynamical equilibrium in the relativistic hydrodynamics. Thus we show that mimetic matter with HD corresponds to an imperfect DM which: i) renormalises the Newton's constant in the Friedmann equations, ii) has zero pressure when there is no extra matter in the universe, iii) survives the inflationary expansion which puts the system on a dynamical attractor with a vanishing shift-charge, iv) perfectly tracks any external matter on this attractor, v) can become the main (and possibly the only) source of DM, provided the shift-symmetry in the HD terms is broken during some small time interval in the radiation domination époque. In the second part of the paper we present a hydrodynamical description of general anisotropic and inhomogeneous configurations of the system. This imperfect mimetic fluid has an energy flow in the field's rest frame. We find that in the Eckart and in the Landau-Lifshitz frames the mimetic fluid possesses nonvanishing vorticity appearing already at the first order in the HD. Thus, the structure formation and gravitational collapse should proceed in a rather different fashion from the simple irrotational DM models

  18. Imperfect Dark Matter

    Science.gov (United States)

    Mirzagholi, Leila; Vikman, Alexander

    2015-06-01

    We consider cosmology of the recently introduced mimetic matter with higher derivatives (HD). Without HD this system describes irrotational dust—Dark Matter (DM) as we see it on cosmologically large scales. DM particles correspond to the shift-charges—Noether charges of the shifts in the field space. Higher derivative corrections usually describe a deviation from the thermodynamical equilibrium in the relativistic hydrodynamics. Thus we show that mimetic matter with HD corresponds to an imperfect DM which: i) renormalises the Newton's constant in the Friedmann equations, ii) has zero pressure when there is no extra matter in the universe, iii) survives the inflationary expansion which puts the system on a dynamical attractor with a vanishing shift-charge, iv) perfectly tracks any external matter on this attractor, v) can become the main (and possibly the only) source of DM, provided the shift-symmetry in the HD terms is broken during some small time interval in the radiation domination époque. In the second part of the paper we present a hydrodynamical description of general anisotropic and inhomogeneous configurations of the system. This imperfect mimetic fluid has an energy flow in the field's rest frame. We find that in the Eckart and in the Landau-Lifshitz frames the mimetic fluid possesses nonvanishing vorticity appearing already at the first order in the HD. Thus, the structure formation and gravitational collapse should proceed in a rather different fashion from the simple irrotational DM models.

  19. Discrete dark matter

    CERN Document Server

    Hirsch, M; Peinado, E; Valle, J W F

    2010-01-01

    We propose a new motivation for the stability of dark matter (DM). We suggest that the same non-abelian discrete flavor symmetry which accounts for the observed pattern of neutrino oscillations, spontaneously breaks to a Z2 subgroup which renders DM stable. The simplest scheme leads to a scalar doublet DM potentially detectable in nuclear recoil experiments, inverse neutrino mass hierarchy, hence a neutrinoless double beta decay rate accessible to upcoming searches, while reactor angle equal to zero gives no CP violation in neutrino oscillations.

  20. Ekologický marketing ve společnosti DM drogeriemarkt

    OpenAIRE

    Bakalářová, Jana

    2014-01-01

    The Bachelor's thesis entitled Green Marketing in DM drogeriemarkt company deals with the analysis of a new marketing approach/attitude also known as an environmental or green marketing, which has become very popular. The two preliminary chapters of my bachelor thesis are devoted to theoretical explanations, terms and definitions on the basis we can more develop it to a deeper description of marketing terms. The following part introduces a green marketing itself from it's definition through h...

  1. submitter Searches for New Physics, involving Top Quarks, Dark Matter and the Higgs Bosons, at the ATLAS, CDF and Fermi-LAT Particle Experiments, and a description of a new limit re-interpretation tool, Basis-Limits

    CERN Document Server

    Rao, Kanury Kanishka

    Searches for new physics are presented in the lepton + jets channel at the CDF and ATLAS experiments. At CDF, we search for exotic quarks that couple to dark matter, new particle resonances in top-quark pairs, a Z' boson decaying quarks, and a two-Higgs doublet model. At ATLAS, we search for fourth generation down-type quarks, new particle resonances in top-quark pairs, and a multi-Higgs boson cascade. A novel methodology, Basis-limits, which allows for re-interpretation of experimental limits is presented. Basis-limits is used to extend ATLAS limits on fourth generation quarks to set limits on a new vector-like quark for all its decay modes. Finally, a spatial analysis of the gamma-ray excess, seen by the Fermi-LAT experiment, is performed. We find the location of the excess to be consistent with a dark matter halo at the Galactic center as the source.

  2. Konfirmasi spesifitas GAD65 terhadap anti-GAD65 pada tikus DM dan pasien DM tipe 1

    Directory of Open Access Journals (Sweden)

    Aulanni’a Aulanni’a

    2012-02-01

    Full Text Available The use of glutamic acid decarboxylase (GAD65 from bovine brain has been studied to obtain basic knowledge and diagnosis and prediction of Type 1 Diabetes Mellitus (DM patients. The importance of GAD65 in DM diagnosis based on its patogenesis. One of the autoimmune marker that can be used to detect beta-pancreas destruction in Diabetes Type I is the antibody to glutamic acid decarboxylase (GAD65. Most of the pre-diabetic patients indicate the reactive autoantibody to GAD65. For early detection of anti-GAD65 in the serum of the patient, human recombinat GAD65 has been succeed to be used. However this is not economical, therefore, it is necessary to find the alternative source of cheaper GAD65. The aim of this research is to develop an early detection kit of Type 1 DM based on antibody- GAD65, since the longest patient suffering from DM has higher probability to be complicated, especially for uncured patients. The anti- GAD65 antibodies induced by anti-GAD65 synthetized and labelled by alkaline phosphatase can be used as reagent detection early DM patients. The ten patients of DM as samples (positive of anti-GAD65 and five rats of DM were positive with western blott technique using reagents as result of this research. It can be concluded, GAD65 enzyme isolated from bovine brain induced anti-GAD65 production and have possibilities to be packaged in a diagnostic kit for patient pre DM.

  3. 1015 PTT Segment MEMS DM Development, Phase I

    Data.gov (United States)

    National Aeronautics and Space Administration — Microelectromechanical systems (MEMS) technology has the potential to create deformable mirrors (DM) with more than 10^4 actuators with size, weight, and power...

  4. Picometer-Resolution MEMS Segmented DM, Phase II

    Data.gov (United States)

    National Aeronautics and Space Administration — Microelectromechanical systems (MEMS) technology has the potential to create deformable mirrors (DM) with 10^4 actuators that have size, weight, and power...

  5. Picometer-Resolution MEMS Segmented DM, Phase I

    Data.gov (United States)

    National Aeronautics and Space Administration — Microelectromechanical systems (MEMS) technology has the potential to create deformable mirrors (DM) with 10^4 actuators that have size, weight, and power...

  6. Analysis of the Soil Organic Matter Stability in Spruce Forests of Krkonose in Czechia on the Basis of the ROMUL Mathematical Model

    Czech Academy of Sciences Publication Activity Database

    Nadporozhskaya, M.A.; Cudlín, Pavel; Novák, František; Bykhovets, S.S.; Chertov, O.G.; Komarov, A.S.; Mikhailov, A.V.

    2009-01-01

    Roč. 42, č. 6 (2009), s. 657-667 ISSN 1064-2293 Institutional research plan: CEZ:AV0Z60870520; CEZ:AV0Z60660521 Keywords : Norway spruce * model ROMUL * soil organic matter Subject RIV: DF - Soil Science Impact factor: 0.222, year: 2009

  7. Dipolar dark matter

    International Nuclear Information System (INIS)

    Masso, Eduard; Mohanty, Subhendra; Rao, Soumya

    2009-01-01

    If dark matter (DM) has nonzero direct or transition, electric or magnetic dipole moment then it can scatter nucleons electromagnetically in direct detection experiments. Using the results from experiments like XENON, CDMS, DAMA, and COGENT, we put bounds on the electric and magnetic dipole moments of DM. If DM consists of Dirac fermions with direct dipole moments, then DM of mass less than 10 GeV is consistent with the DAMA signal and with null results of other experiments. If on the other hand DM consists of Majorana fermions then they can have only nonzero transition moments between different mass eigenstates. We find that Majorana fermions with masses 38 χ < or approx. 100-200 GeV and mass splitting of the order of (150-200) keV can explain the DAMA signal and the null observations from other experiments and in addition give the observed relic density of DM by dipole-mediated annihilation. The absence of the heavier DM state in the present Universe can be explained by dipole-mediated radiative decay. This parameter space for the mass and for dipole moments is allowed by limits from L3 but may have observable signals at LHC.

  8. CONSTRAINT ON LIGHT DIPOLE DARK MATTER FROM HELIOSEISMOLOGY

    Energy Technology Data Exchange (ETDEWEB)

    Lopes, Ilídio [Centro Multidisciplinar de Astrofísica, Instituto Superior Técnico, Universidade de Lisboa, Av. Rovisco Pais, 1049-001 Lisboa (Portugal); Kadota, Kenji [Department of Physics, Nagoya University, Nagoya 464-8602 (Japan); Silk, Joseph, E-mail: ilidio.lopes@ist.utl.pt, E-mail: ilopes@uevora.pt, E-mail: kadota.kenji@f.nagoya-u.jp, E-mail: silk@astro.ox.ac.uk [Institut d' Astrophysique de Paris, UMR 7095 CNRS, Université Pierre et Marie Curie, 98 bis Boulevard Arago, F-75014 Paris (France)

    2014-01-10

    We investigate the effects of a magnetic dipole moment of asymmetric dark matter (DM) in the evolution of the Sun. The dipole interaction can lead to a sizable DM scattering cross section even for light DM, and asymmetric DM can lead to a large DM number density in the Sun. We find that solar model precision tests, using as diagnostic the sound speed profile obtained from helioseismology data, exclude dipolar DM particles with a mass larger than 4.3 GeV and magnetic dipole moment larger than 1.6 × 10{sup –17} e cm.

  9. Management of newly diagnosed type 2 Diabetes Mellitus (T2DM) in children and adolescents.

    Science.gov (United States)

    Copeland, Kenneth C; Silverstein, Janet; Moore, Kelly R; Prazar, Greg E; Raymer, Terry; Shiffman, Richard N; Springer, Shelley C; Thaker, Vidhu V; Anderson, Meaghan; Spann, Stephen J; Flinn, Susan K

    2013-02-01

    Over the past 3 decades, the prevalence of childhood obesity has increased dramatically in North America, ushering in a variety of health problems, including type 2 diabetes mellitus (T2DM), which previously was not typically seen until much later in life. The rapid emergence of childhood T2DM poses challenges to many physicians who find themselves generally ill-equipped to treat adult diseases encountered in children. This clinical practice guideline was developed to provide evidence-based recommendations on managing 10- to 18-year-old patients in whom T2DM has been diagnosed. The American Academy of Pediatrics (AAP) convened a Subcommittee on Management of T2DM in Children and Adolescents with the support of the American Diabetes Association, the Pediatric Endocrine Society, the American Academy of Family Physicians, and the Academy of Nutrition and Dietetics (formerly the American Dietetic Association). These groups collaborated to develop an evidence report that served as a major source of information for these practice guideline recommendations. The guideline emphasizes the use of management modalities that have been shown to affect clinical outcomes in this pediatric population. Recommendations are made for situations in which either insulin or metformin is the preferred first-line treatment of children and adolescents with T2DM. The recommendations suggest integrating lifestyle modifications (ie, diet and exercise) in concert with medication rather than as an isolated initial treatment approach. Guidelines for frequency of monitoring hemoglobin A1c (HbA1c) and finger-stick blood glucose (BG) concentrations are presented. Decisions were made on the basis of a systematic grading of the quality of evidence and strength of recommendation. The clinical practice guideline underwent peer review before it was approved by the AAP. This clinical practice guideline is not intended to replace clinical judgment or establish a protocol for the care of all children with T2

  10. Testing Lorentz invariance of dark matter

    CERN Document Server

    Blas, Diego; Sibiryakov, Sergey

    2012-01-01

    We study the possibility to constrain deviations from Lorentz invariance in dark matter (DM) with cosmological observations. Breaking of Lorentz invariance generically introduces new light gravitational degrees of freedom, which we represent through a dynamical timelike vector field. If DM does not obey Lorentz invariance, it couples to this vector field. We find that this coupling affects the inertial mass of small DM halos which no longer satisfy the equivalence principle. For large enough lumps of DM we identify a (chameleon) mechanism that restores the inertial mass to its standard value. As a consequence, the dynamics of gravitational clustering are modified. Two prominent effects are a scale dependent enhancement in the growth of large scale structure and a scale dependent bias between DM and baryon density perturbations. The comparison with the measured linear matter power spectrum in principle allows to bound the departure from Lorentz invariance of DM at the per cent level.

  11. Testing Lorentz invariance of dark matter

    Energy Technology Data Exchange (ETDEWEB)

    Blas, Diego [Theory Group, Physics Department, CERN, CH-1211 Geneva 23 (Switzerland); Ivanov, Mikhail M.; Sibiryakov, Sergey, E-mail: diego.blas@cern.ch, E-mail: mm.ivanov@physics.msu.ru, E-mail: sibir@inr.ac.ru [Faculty of Physics, Moscow State University, Vorobjevy Gory, 119991 Moscow (Russian Federation)

    2012-10-01

    We study the possibility to constrain deviations from Lorentz invariance in dark matter (DM) with cosmological observations. Breaking of Lorentz invariance generically introduces new light gravitational degrees of freedom, which we represent through a dynamical timelike vector field. If DM does not obey Lorentz invariance, it couples to this vector field. We find that this coupling affects the inertial mass of small DM halos which no longer satisfy the equivalence principle. For large enough lumps of DM we identify a (chameleon) mechanism that restores the inertial mass to its standard value. As a consequence, the dynamics of gravitational clustering are modified. Two prominent effects are a scale dependent enhancement in the growth of large scale structure and a scale dependent bias between DM and baryon density perturbations. The comparison with the measured linear matter power spectrum in principle allows to bound the departure from Lorentz invariance of DM at the per cent level.

  12. Senam efektif Menurunkan Kadar Gula Darah Pasien DM Tipe 2

    Directory of Open Access Journals (Sweden)

    Jati Ekawati

    2018-01-01

    Full Text Available Background: Diabetes is one of the major threats to human health in the 21st century. Indonesia's own country with diabetes mellitus was ranked the world's fourth largest with 8.6% of the total prevalence of diabetes sufferers after India, China, and the United States. Factors that influence diabetes include; 1 age, 2 Obesity, 3 Family History, and 4 ethnic group. There are four pillars of prevention in Indonesia which is applied to the diabetes to control blood sugar levels, namely: 1 diet, 2 Physical Exercise, 3 medications, and 4 Health Education. Objective: To determine the effect of physical exercises Gymnastic DM administration and Gymnastic Senior to decrease blood sugar levels in patients with type 2 diabetes. Method: This study is a quantitative study with this type of study without a comparison group quasy experiments. The design of the study is a pretest-posttest one group design. Number of samples used were 41 respondents from the participants calisthenics DM in the psychiatric hospital. Prof. dr. Soerojo Magelang. Analysis of the data used is the analysis bivariabel univariabel and analysis using statistical models Paired sample t-tests with significance level α = 0.05. Result: There was a decrease in blood sugar levels after exercise DM for 3 times a week for 2 weeks, an average of 64.780 mg/dl. T count value obtained at 13.624 with a p-value 0.000 <0.05, means that there are significant differences in blood sugar levels before and after doing gymnastic DM and Gymnastic Senior. Conclusion: The provision of physical training exercises conducted by DM DM participants calisthenics in Prof. RSJ. Dr. Soerojo Magelang for 3 times a week for 2 weeks can lower blood sugar levels in patients with type 2 diabetes mellitus.

  13. Molecular mechanisms in DM1 - a focus on foci

    DEFF Research Database (Denmark)

    Pettersson, Olof Joakim; Aagaard, Lars; Jensen, Thomas G.

    2015-01-01

    -expanded RNA remains in the nuclear compartment, while in dividing cells such as fibroblasts a considerable fraction of the mutant RNA reaches the cytoplasm, consistent with findings that both nuclear and cytoplasmic events are mis-regulated in DM1. Recent evidence suggests that the nuclear aggregates......, or ribonuclear foci, are more dynamic than previously anticipated and regulated by several proteins, including RNA helicases. In this review, we focus on the homeostasis of DMPK mRNA foci and discuss how their dynamic regulation may affect disease-causing mechanisms in DM1...

  14. Evading direct dark matter detection in Higgs portal models

    Energy Technology Data Exchange (ETDEWEB)

    Arcadi, Giorgio [Max Planck Institut für Kernphysik, Saupfercheckweg 1, D-69117 Heidelberg (Germany); Gross, Christian, E-mail: christian.gross@helsinki.fi [Department of Physics and Helsinki Institute of Physics, Gustaf Hällströmin katu 2, FI-00014 Helsinki (Finland); Lebedev, Oleg [Department of Physics and Helsinki Institute of Physics, Gustaf Hällströmin katu 2, FI-00014 Helsinki (Finland); Pokorski, Stefan [Institute of Theoretical Physics, University of Warsaw, Pasteura 5, PL-02-093 Warsaw (Poland); Toma, Takashi [Physik-Department T30d, Technische Universität München, James-Franck-Straße, D-85748 Garching (Germany)

    2017-06-10

    Many models of Higgs portal Dark Matter (DM) find themselves under pressure from increasingly tight direct detection constraints. In the framework of gauge field DM, we study how such bounds can be relaxed while retaining the thermal WIMP paradigm. When the hidden sector gauge symmetry is broken via the Higgs mechanism, the hidden sector generally contains unstable states which are lighter than dark matter. These states provide DM with an efficient annihilation channel. As a result, the DM relic abundance and the direct detection limits are controlled by different parameters, and the two can easily be reconciled. This simple setup realizes the idea of “secluded” dark matter naturally.

  15. Polyuria with the Concurrent manifestation of Central Diabetes Insipidus (CDI) & Type 2 Diabetes Mellitus (DM).

    Science.gov (United States)

    Shin, Hyun-Jong; Kim, Jae-Ha; Yi, Joo-Hark; Han, Sang-Woong; Kim, Ho-Jung

    2012-12-01

    We report a rare case of the concurrent manifestation of central diabetes insipidus (CDI) and type 2 diabetes mellitus (DM). A 56 year-old man was diagnosed as a type 2 DM on the basis of hyperglycemia with polyuria and polydipsia at a local clinic two months ago and started an oral hypoglycemic medication, but resulted in no symptomatic improvement at all. Upon admission to the university hospital, the patient's initial fasting blood sugar level was 140 mg/dL, and he showed polydipsic and polyuric conditions more than 8 L urine/day. Despite the hyperglycemia controlled with metformin and diet, his symptoms persisted. Further investigations including water deprivation test confirmed the coexisting CDI of unknown origin, and the patient's symptoms including an intense thirst were markedly improved by desmopressin nasal spray (10 µg/day). The possibility of a common origin of CDI and type 2 DM is raised in a review of the few relevant adult cases in the literature.

  16. Insulin initiation and intensification in patients with T2DM for the primary care physician

    Directory of Open Access Journals (Sweden)

    Unger J

    2011-06-01

    Full Text Available Jeff UngerCatalina Research Institute, Chino, CA, USAAbstract: Type 2 diabetes mellitus (T2DM is characterized by both insulin resistance and inadequate insulin secretion. All patients with the disease require treatment to achieve and maintain the target glycosylated hemoglobin (A1C level of 6.5%–7%. Pharmacological management of T2DM typically begins with the introduction of oral medications, and the majority of patients require exogenous insulin therapy at some point in time. Primary care physicians play an essential role in the management of T2DM since they often initiate insulin therapy and intensify regimens over time as needed. Although insulin therapy is prescribed on an individualized basis, treatment usually begins with basal insulin added to a background therapy of oral agents. Prandial insulin injections may be added if glycemic targets are not achieved. Treatments may be intensified over time using patient-friendly titration algorithms. The goal of insulin intensification within the primary care setting is to minimize patients' exposure to chronic hyperglycemia and weight gain, and reduce patients' risk of hypoglycemia, while achieving individualized fasting, postprandial, and A1C targets. Simplified treatment protocols and insulin delivery devices allow physicians to become efficient prescribers of insulin intensification within the primary care arena.Keywords: diabetes, basal, bolus, regimens, insulin analogs, structured glucose testing

  17. Flavoured Dark Matter moving left

    Science.gov (United States)

    Blanke, Monika; Das, Satrajit; Kast, Simon

    2018-02-01

    We investigate the phenomenology of a simplified model of flavoured Dark Matter (DM), with a dark fermionic flavour triplet coupling to the left-handed SU(2) L quark doublets via a scalar mediator. The DM-quark coupling matrix is assumed to constitute the only new source of flavour and CP violation, following the hypothesis of Dark Minimal Flavour Violation. We analyse the constraints from LHC searches, from meson mixing data in the K, D, and B d,s meson systems, from thermal DM freeze-out, and from direct detection experiments. Our combined analysis shows that while the experimental constraints are similar to the DMFV models with DM coupling to right-handed quarks, the multitude of couplings between DM and the SM quark sector resulting from the SU(2) L structure implies a richer phenomenology and significantly alters the resulting impact on the viable parameter space.

  18. Produção de matéria seca e absorção de nutrientes pelo milho em razão da saturação por bases e da adubação potássica Dry matter yield and nutrient uptake in corn plants as a function of potassic fertilization and of basis soil saturation

    Directory of Open Access Journals (Sweden)

    MARCELO ANDREOTTI

    2000-12-01

    Full Text Available O trabalho foi conduzido em condições de casa de vegetação, com o objetivo de avaliar a resposta do milho à adubação potássica e à saturação do solo por bases, na produção de matéria seca e na absorção de nutrientes. O delineamento experimental foi inteiramente casualizado, com quatro repetições, em esquema fatorial 3x2x4, constituindo-se de três solos (Areia Quartzosa, Latossolo Vermelho-Escuro e Latossolo Roxo, dois valores de saturação por bases (40% e 70 % e quatro teores de K no solo (0,5, 1,5, 3,0 e 6,0 mmol c dm-3. Para a calagem, foi utilizada mistura de carbonato de cálcio + carbonato de magnésio (PRNT = 103,3 % na proporção de 4:1. A adubação básica constou de 200 mg kg-1 de N, 200 mg kg-1 de P e 5 mg kg-1 de Zn por vaso de 30 L, sendo o N parcelado em 2,48 g (83,7 mg kg-1 na semeadura e o restante em duas coberturas aos 25 e 40 dias após a emergência das plântulas (DAE. As doses de K utilizadas foram de 0, 3,62, 7,24 e 14,48 g de KCl por vaso. A semeadura foi realizada em 4/3/97, utilizando-se o milho cv. Zêneca 8392, mantendo-se uma planta/vaso durante 60 DAE. O K proporciona ganhos de matéria seca até teores de 1,5 mmol c dm-3 no solo. O aumento dos teores de K no solo resultam em queda na concentração de Ca e Mg na matéria seca do milho. A elevação da saturação por bases e respectivo aumento dos teores de Ca e Mg no solo reduzem a absorção de K pelo milho.The purpose of this research was to study dry matter yield and nutrients uptake by corn plants as a function of potassic fertilization and of soil basis saturation. An experiment was conducted under greenhouse conditions, using an early single hybrid corn Zêneca 8392 grown in 30 L pots, tested with three types of soil (Quartzpsamment and two alic Dark-Red Latosol - Haplorthox, with two levels of basis saturation (40 and 70 % and four levels of potassium content (0.5, 1.5, 3.0 and 6.0 mmol c dm-3. A completely random design with four

  19. Unblinding the dark matter blind spots

    International Nuclear Information System (INIS)

    Han, Tao; Kling, Felix

    2017-01-01

    The dark matter (DM) blind spots in the Minimal Supersymmetric Standard Model (MSSM) refer to the parameter regions where the couplings of the DM particles to the Z-boson or the Higgs boson are almost zero, leading to vanishingly small signals for the DM direct detections. In this paper, we carry out comprehensive analyses for the DM searches under the blind-spot scenarios in MSSM. Guided by the requirement of acceptable DM relic abundance, we explore the complementary coverage for the theory parameters at the LHC, the projection for the future underground DM direct searches, and the indirect searches from the relic DM annihilation into photons and neutrinos. We find that (i) the spin-independent (SI) blind spots may be rescued by the spin-dependent (SD) direct detection in the future underground experiments, and possibly by the indirect DM detections from IceCube and SuperK neutrino experiments; (ii) the detection of gamma rays from Fermi-LAT may not reach the desirable sensitivity for searching for the DM blind-spot regions; (iii) the SUSY searches at the LHC will substantially extend the discovery region for the blind-spot parameters. As a result, the dark matter blind spots thus may be unblinded with the collective efforts in future DM searches.

  20. Existence of dark matter with observed properties of cosmic microwave background radiation substantiates three conservation laws of classical physics and all principles of quantum mechanics as creates the value of Planck’s constant

    Science.gov (United States)

    Boriev, I. A.

    2018-03-01

    Astronomical data indicate a presence of dark matter (DM) in the space, what is necessary for explanation of observed dynamics of the galaxies within Newtonian mechanics. DM, at its very low density (∼10-26kg/m3), constitutes main part of the matter in the Universe, 10 times the mass of all visible cosmic bodies. No doubt, namely properties of DM, which fills space, must determine its physical properties and fundamental physical laws. Taking into account observed properties of cosmic microwave background radiation (CMBR), whose energy is ∼90% of all cosmic radiation, and understanding that this radiation is produced by DM motion, conservation laws of classical physics and principles of quantum mechanics receive their materialistic substantiation. Thus, CMBR high homogeneity and isotropy (∼10-4), and hence the same properties of DM (and space) justify momentum and angular momentum conservation laws, respectively, according to E. Noether's theorems. CMBR has black body spectrum at ∼2.7K with maximum wavelength ∼1.9·10-3m, what allows calculate the value of mechanical action produced by DM thermal motion (∼7·10-34 J·s). This value corresponds well to the Planck’s constant, which is the mechanical action too, what gives materialistic basis for all principles of quantum mechanics. Obtained results directly confirm the reality of DM existence, and show that CMBR is an observed display of DM thermal motion. Understanding that namely from DM occur known creation of electron-positron pairs as contrarily rotating material vortexes (according to their spins) let substantiate positron nature of ball lightning what first explains all its observed specific properties.

  1. Semiautomatic estimation of breast density with DM-Scan software.

    Science.gov (United States)

    Martínez Gómez, I; Casals El Busto, M; Antón Guirao, J; Ruiz Perales, F; Llobet Azpitarte, R

    2014-01-01

    To evaluate the reproducibility of the calculation of breast density with DM-Scan software, which is based on the semiautomatic segmentation of fibroglandular tissue, and to compare it with the reproducibility of estimation by visual inspection. The study included 655 direct digital mammograms acquired using craniocaudal projections. Three experienced radiologists analyzed the density of the mammograms using DM-Scan, and the inter- and intra-observer agreement between pairs of radiologists for the Boyd and BI-RADS® scales were calculated using the intraclass correlation coefficient. The Kappa index was used to compare the inter- and intra-observer agreements with those obtained previously for visual inspection in the same set of images. For visual inspection, the mean interobserver agreement was 0,876 (95% CI: 0,873-0,879) on the Boyd scale and 0,823 (95% CI: 0,818-0,829) on the BI-RADS® scale. The mean intraobserver agreement was 0,813 (95% CI: 0,796-0,829) on the Boyd scale and 0,770 (95% CI: 0,742-0,797) on the BI-RADS® scale. For DM-Scan, the mean inter- and intra-observer agreement was 0,92, considerably higher than the agreement for visual inspection. The semiautomatic calculation of breast density using DM-Scan software is more reliable and reproducible than visual estimation and reduces the subjectivity and variability in determining breast density. Copyright © 2012 SERAM. Published by Elsevier Espana. All rights reserved.

  2. Galaxy and cluster formation in a universe dominated by cold dark matter

    International Nuclear Information System (INIS)

    Primack, J.R.

    1984-07-01

    The dark matter (DM) that appears to be gravitationally dominant on all astronomical scales larger than the cores of galaxies can be classified, on the basis of its characteristic free-streaming damping mass M/sub D/, as hot (M/sub D/ approx. 10 15 M/sub mass/), warm (M/sub D/ approx. 10 11 M/sub mass/), or cold (M/sub D 8 M/sub mass/). For the case of cold DM, the shape of the DM fluctuation spectrum is determined by (a) the primordial spectrum (on scales larger than the horizon), and (b) stagspansion, the stagnation of the growth of DM fluctuations that enter the horizon while the universe is still radiation-dominated. An attractive feature of the cold dark matter hypothesis is its considerable predictive power: the post-recombination fluctuation spectrum is calculable, and it in turn governs the formation of galaxies and clusters. Good agreement with the data is obtained for a Zeldovich spectrum of primordial fluctuations

  3. Galaxy and cluster formation in a universe dominated by cold dark matter

    Energy Technology Data Exchange (ETDEWEB)

    Primack, J.R.

    1984-07-01

    The dark matter (DM) that appears to be gravitationally dominant on all astronomical scales larger than the cores of galaxies can be classified, on the basis of its characteristic free-streaming damping mass M/sub D/, as hot (M/sub D/ approx. 10/sup 15/ M/sub mass/), warm (M/sub D/ approx. 10/sup 11/ M/sub mass/), or cold (M/sub D < 10/sup 8/ M/sub mass/). For the case of cold DM, the shape of the DM fluctuation spectrum is determined by (a) the primordial spectrum (on scales larger than the horizon), and (b) stagspansion, the stagnation of the growth of DM fluctuations that enter the horizon while the universe is still radiation-dominated. An attractive feature of the cold dark matter hypothesis is its considerable predictive power: the post-recombination fluctuation spectrum is calculable, and it in turn governs the formation of galaxies and clusters. Good agreement with the data is obtained for a Zeldovich spectrum of primordial fluctuations.

  4. Dark matter in spiral galaxies

    International Nuclear Information System (INIS)

    Persic, M.; Salucci, P.

    1990-01-01

    The Tully-Fisher relation is used to probe dark matter (DM) in the optical regions of spiral galaxies. By establishing it at several different isophotal radii in an appropriate sample of 58 galaxies with good B-band photometry and rotation curves, it is shown that some of its attributes (such as scatter, residuals, nonlinearity, and bias) dramatically decrease moving from the disk edge inward. This behavior challenges any mass model which assumes no DM or a luminosity-independent DM mass fraction interior to the optical radius of spiral galaxies. 58 refs

  5. Interacting dark matter disguised as warm dark matter

    International Nuclear Information System (INIS)

    Boehm, Celine; Riazuelo, Alain; Hansen, Steen H.; Schaeffer, Richard

    2002-01-01

    We explore some of the consequences of dark-matter-photon interactions on structure formation, focusing on the evolution of cosmological perturbations and performing both an analytical and a numerical study. We compute the cosmic microwave background anisotropies and matter power spectrum in this class of models. We find, as the main result, that when dark matter and photons are coupled, dark matter perturbations can experience a new damping regime in addition to the usual collisional Silk damping effect. Such dark matter particles (having quite large photon interactions) behave like cold dark matter or warm dark matter as far as the cosmic microwave background anisotropies or matter power spectrum are concerned, respectively. These dark-matter-photon interactions leave specific imprints at sufficiently small scales on both of these two spectra, which may allow us to put new constraints on the acceptable photon-dark-matter interactions. Under the conservative assumption that the abundance of 10 12 M · galaxies is correctly given by the cold dark matter, and without any knowledge of the abundance of smaller objects, we obtain the limit on the ratio of the dark-matter-photon cross section to the dark matter mass σ γ-DM /m DM -6 σ Th /(100 GeV)≅6x10 -33 cm 2 GeV -1

  6. The search for Dark Matter in our galaxy; Suche nach Dunkler Materie in unserer Galaxie

    Energy Technology Data Exchange (ETDEWEB)

    Eitel, K. [Forschungszentrum Karlsruhe GmbH Technik und Umwelt (Germany). Inst. fuer Kernphysik; Boer, W. de [Karlsruhe Univ. (T.H.) (Germany). Inst. fuer Experimentelle Kernphysik

    2007-07-01

    The matter content in galaxies like the Milky Way as well as in the entire Universe is dominated by Dark Matter (DM). The nature of this DM is one of the great enigmas of modern astroparticle physics. A promising candidate for this DM is a weakly interacting massive particle (WIMP). DM can then be detected directly via rare elastic collisions of WIMPs with atomic nuclei in a well shielded underground detector or via the decay products from the annihilation of two WIMPs. Energetic gamma rays in cosmic radiation might therefore indicate an indirect signal of DM particles in our galaxy. We present two experimental approaches to search for WIMP Dark Matter. (orig.)

  7. Charged composite scalar dark matter

    Science.gov (United States)

    Balkin, Reuven; Ruhdorfer, Maximilian; Salvioni, Ennio; Weiler, Andreas

    2017-11-01

    We consider a composite model where both the Higgs and a complex scalar χ, which is the dark matter (DM) candidate, arise as light pseudo Nambu-Goldstone bosons (pNGBs) from a strongly coupled sector with TeV scale confinement. The global symmetry structure is SO(7)/SO(6), and the DM is charged under an exact U(1)DM ⊂ SO(6) that ensures its stability. Depending on whether the χ shift symmetry is respected or broken by the coupling of the top quark to the strong sector, the DM can be much lighter than the Higgs or have a weak-scale mass. Here we focus primarily on the latter possibility. We introduce the lowest-lying composite resonances and impose calculability of the scalar potential via generalized Weinberg sum rules. Compared to previous analyses of pNGB DM, the computation of the relic density is improved by fully accounting for the effects of the fermionic top partners. This plays a crucial role in relaxing the tension with the current DM direct detection constraints. The spectrum of resonances contains exotic top partners charged under the U(1)DM, whose LHC phenomenology is analyzed. We identify a region of parameters with f = 1.4 TeV and 200 GeV ≲ m χ ≲ 400 GeV that satisfies all existing bounds. This DM candidate will be tested by XENON1T in the near future.

  8. Extended micro objects as dark matter particles

    Science.gov (United States)

    Belotsky, K.; Rubin, S.; Svadkovsky, I.

    2017-05-01

    Models of various forms of composite dark matter (DM) predicted by particle theory and the DM constituents formed by gravity that are not reduced to new elementary particle candidates are discussed. Main attention is paid to a gravitational origin of the DM. The influence of extended mass spectrum of primordial black holes on observational limits is considered. It is shown that non-uniformly deformed extra space can be considered as point-like masses which possess only gravitational interaction with each other and with the ordinary particles. The recently discussed six-dimensional stable wormholes could contribute to the DM. The contribution of dark atoms is also considered.

  9. Decaying Dark Matter at the LHC

    CERN Multimedia

    CERN. Geneva

    2015-01-01

    We discuss a few scenarios with decaying Dark Matter and their prospect for detection at the LHC. First we present a simple minimal scenario, where Dark Matter is produced from the decay of a heavier colored or EW charged scalar via the FIMP or SuperWIMP mechanisms, then we discuss supersymmetric scenarios with RPV and gravitino DM, in particular a scenario allowing for simultaneous generation of DM and baryogenesis at a (relatively) low scale.

  10. Distinguishing Dark Matter Stabilization Symmetries at Hadron Colliders with Mass Variables

    CERN Document Server

    Kim, Heejoo

    2017-01-01

    Cosmological and astrophysical observations, yet all gravitational, suggest that there exists stable matter, so-called dark matter (DM), in our universe, which is exerting gravity but hardly detectable in relevant experiments. The stability of DM indicates that DM needs to be either massless or protected by a new symmetry (henceforth called DM stabilizing symmetry) preventing its decay. It turns out that cosmological consideration suggests that massless particles be unlikely to constitute a dominant portion of the DM, motivating DM candidates with a sizable mass. While a massive particle, in general, may decay into lighter particles, the charge conservation associated with the symmetry ensures the stability of DM. There is a tremendous amount of effort in the search for DM candidates and it also comprises collider experiments. DM is, by definition, hard to be detected at colliders such as the LHC. So, its existence may be inferred from (visible) Standard Model (SM) particles emitted from a decay chain of a...

  11. Hyperuricaemia and the metabolic syndrome in type 2 DM

    Directory of Open Access Journals (Sweden)

    Ogbera Anthonia O

    2010-04-01

    Full Text Available Abstract Background Elevated serum uric acid levels (SUA have been associated with an increased risk of cardiovascular diseases and the metabolic syndrome (MetS and are often reported to be higher in females than in males. The aim of this report is to determine the prevalence and clinical correlates of hyperuricaemia and also to evaluate associations with the MetS in people with type 2 diabetes mellitus (DM. Methods This was a cross-sectional study conducted in people with type 2 DM in Lagos, Nigeria. Hyperuricaemia was defined by cut-off values of > 7 mg/dl for men and > 6 mg/dl for women. The diagnosis of MetS was made using the new definition by the American Heart Association and other related bodies. Clinical and biochemical parameters were compared between subjects with hyperuricaemia and normouricaemia. Statistical analysis included usage of Student's t test, Pearson correlation coefficients, multivariate regression analysis and chi square. Results 601 patients with type 2 DM aged between 34-91 years were recruited for the study. The prevalence rates of hyperuricaemia and the MetS were 25% and 60% respectively. The frequency of occurrence of hyperuricaemia was comparable in both genders (59% vs 41%, p = 0.3. Although, the prevalence of the MetS in subjects with hyperuricaemia and normouricaemia was comparable (61 vs 56%, p = 0.1, a higher proportion of hyperuricaemic subjects had 3 or more components of the Mets compared with normouricaemic subjects. Possible predictors of hyperuricaemia include central obesity, smoking and elevated serum triglycerides (TG. SUA levels were found to be positively and significantly associated with serum TG (r = 0.2, p = 0.0001 and total cholesterol (r = 13, p = 0.001. Conclusion The prevalence of hyperuricaemia in subjects with type 2 DM is comparable in both genders and possible predictors of hyperuricaemia are potentially modifiable. SUA is positively and significantly associated with serum TG and total

  12. Identifying Bank Frauds Using CRISP-DM and Decision Trees

    OpenAIRE

    Bruno Carneiro da Rocha; Rafael Timóteo de Sousa Júnior

    2010-01-01

    This article aims to evaluate the use of techniques of decision trees, in conjunction with the managementmodel CRISP-DM, to help in the prevention of bank fraud. This article offers a study on decision trees, animportant concept in the field of artificial intelligence. The study is focused on discussing how these treesare able to assist in the decision making process of identifying frauds by the analysis of informationregarding bank transactions. This information is captured with the use of t...

  13. Focal plane based wavefront sensing with random DM probes

    Science.gov (United States)

    Pluzhnik, Eugene; Sirbu, Dan; Belikov, Ruslan; Bendek, Eduardo; Dudinov, Vladimir N.

    2017-09-01

    An internal coronagraph with an adaptive optical system for wavefront control is being considered for direct imaging of exoplanets with upcoming space missions and concepts, including WFIRST, HabEx, LUVOIR, EXCEDE and ACESat. The main technical challenge associated with direct imaging of exoplanets is to control of both diffracted and scattered light from the star so that even a dim planetary companion can be imaged. For a deformable mirror (DM) to create a dark hole with 10-10 contrast in the image plane, wavefront errors must be accurately measured on the science focal plane detector to ensure a common optical path. We present here a method that uses a set of random phase probes applied to the DM to obtain a high accuracy wavefront estimate even for a dynamically changing optical system. The presented numerical simulations and experimental results show low noise sensitivity, high reliability, and robustness of the proposed approach. The method does not use any additional optics or complex calibration procedures and can be used during the calibration stage of any direct imaging mission. It can also be used in any optical experiment that uses a DM as an active optical element in the layout.

  14. Asymmetric Dark Matter and Dark Radiation

    CERN Document Server

    Blennow, Mattias; Mena, Olga; Redondo, Javier; Serra, Paolo

    2012-01-01

    Asymmetric Dark Matter (ADM) models invoke a particle-antiparticle asymmetry, similar to the one observed in the Baryon sector, to account for the Dark Matter (DM) abundance. Both asymmetries are usually generated by the same mechanism and generally related, thus predicting DM masses around 5 GeV in order to obtain the correct density. The main challenge for successful models is to ensure efficient annihilation of the thermally produced symmetric component of such a light DM candidate without violating constraints from collider or direct searches. A common way to overcome this involves a light mediator, into which DM can efficiently annihilate and which subsequently decays into Standard Model particles. Here we explore the scenario where the light mediator decays instead into lighter degrees of freedom in the dark sector that act as radiation in the early Universe. While this assumption makes indirect DM searches challenging, it leads to signals of extra radiation at BBN and CMB. Under certain conditions, pre...

  15. PENGARUH PENDIDIKAN KESEHATAN TENTANG DIET DM TERHADAP PENINGKATAN PENGETAHUAN KELUARGA PENDERITA DM DI KELURAHAN BANYURADEN KECAMATAN GAMPING

    Directory of Open Access Journals (Sweden)

    Edi Nurrohmad

    2015-04-01

    Full Text Available Background:The number of people with diabetes mellitus in the world in 2030 is expected to114%.Families can be a very influential factor in determining treatment program diabetes mellitus. Knowledge ofdiabetes mellitus family owned very necessary to improve the health status of the family, asa family shouldgive good attention and care to the family members of people with diabetes mellitus.Objective:To determine the effectivity of health education about diabetes mellitus dietary to improving ofknowledge in family with DM disease in the banyuraden district.Method:This research Design is Pre Experimental with pretest-posttest control group design. The Sampleswas choosen by purposive sampling technique, family with diabetes mellitus disease in Banyuraden,Gamping District of Sleman as much as 36 respondent. The research instrument was used questionnaireand it was analyzed byIndependent Sample t-test.Results: level of knowledge family with diabetes mellitus disease about diabetes mellitus dietary onintervention and control group before given health education mayoritas is 55.6% less. After 7 days the levelof knowledge intervention group became 66.7%, and control group is enough 72.2%. The results ofindependent sample t-test test between intervention and control group design shown that p-value = 0.000.Conclusion:There is an effectivity of health education about DM dietary to improving of knowledge in familywith DM disease in the banyuraden district gamping.

  16. On the interpretation of dark matter self-interactions in Abell 3827

    DEFF Research Database (Denmark)

    Kahlhoefer, Felix; Schmidt-Hoberg, Kai; Kummer, Janis

    2015-01-01

    Self-interactions of dark matter (DM) particles can potentially lead to an observable separation between the DM halo and the stars of a galaxy moving through a region of large DM density. Such a separation has recently been observed in a galaxy falling into the core of the galaxy cluster Abell 3827...

  17. Enzymatic Hydrolysis of biomasses having a high dry matter (DM) content

    DEFF Research Database (Denmark)

    2010-01-01

    that the biomasses are subjected to mechanical forces, primarily shear and tear forces. Furthermore, the present invention relates to the further utilization of such processed biomasses, e.g. for subsequent fermentation into bio-ethanol, bio-gas, specialty carbohydrates for food and fees as well as carbon feedstock...... for processing into plastics and chemicals....

  18. Black hole genesis of dark matter

    Science.gov (United States)

    Lennon, Olivier; March-Russell, John; Petrossian-Byrne, Rudin; Tillim, Hannah

    2018-04-01

    We present a purely gravitational infra-red-calculable production mechanism for dark matter (DM) . The source of both the DM relic abundance and the hot Standard Model (SM) plasma is a primordial density of micro black holes (BHs), which evaporate via Hawking emission into both the dark and SM sectors. The mechanism has four qualitatively different regimes depending upon whether the BH evaporation is 'fast' or 'slow' relative to the initial Hubble rate, and whether the mass of the DM particle is 'light' or 'heavy' compared to the initial BH temperature. For each of these regimes we calculate the DM yield, Y, as a function of the initial state and DM mass and spin. In the 'slow' regime Y depends on only the initial BH mass over a wide range of initial conditions, including scenarios where the BHs are a small fraction of the initial energy density. The DM is produced with a highly non-thermal energy spectrum, leading in the 'light' DM mass regime (~260 eV and above depending on DM spin) to a strong constraint from free-streaming, but also possible observational signatures in structure formation in the spin 3/2 and 2 cases. The 'heavy' regime (~1.2 × 108 GeV to MPl depending on spin) is free of these constraints and provides new possibilities for DM detection. In all cases there is a dark radiation component predicted.

  19. Evidence of dark matter from biological observations

    International Nuclear Information System (INIS)

    Zioutas, K.

    1990-01-01

    In accordance with the generally accepted properties of dark matter (DM) candidates, the probability of their interaction with living matter must be equal to that for inorganic matter, and the expected effects might be unique and provide the etiology related to the appearance of several biological phenomena having sometimes fatal late effects. Although collisions with DM are rare, the charged secondaries (recoiling atoms) are expected to be high linear energy transfer particles favouring the highest relative biological effectiveness values for this, as yet invisible, part of the natural background radiation. A few cases are given, where a correlation between DM interaction and phenomena in living matter might already exist, or can show up in existing data: biorhythms with periodicities identical to known cosmic frequencies are explainable with gravitationally clustered DM around the sun, the moon, the earth, etc. The observed arrhythmia, when biological probes are moved (in airplanes, satellites, etc.) support this idea strongly. It is also proposed to implement some of the biological properties and processes (such as element composition and chemical reactions) in future DM detectors in order to improve their sensitivity. The interdisciplinary feedback is bidirectional: huge DM detectors could be used in attempt to understand enigmatic biological behaviour. (orig.)

  20. Method of Multiobject Detecting and Tracking Based on DM643

    Directory of Open Access Journals (Sweden)

    Yitao Liang

    2014-01-01

    Full Text Available The technology of moving objects detection has become an important research subject for its extensive application prospect. In this paper, it is presented that interframe difference algorithm and background difference algorithm are combined to update the background. The algorithm can deal with the flaw of background difference algorithm. The mathematical morphology method is employed to denoise the image, which may be helpful to improve the accuracy of the detection. The Pyramid algorithm is used to compress each frame data of video sequence. Then, the detecting and tracking of moving objects are tested on the hardware platform (DM643 and the software frame (RF5. The running speed is about 3 times faster than before. The result shows that the accuracy demanded by the detection is met. This method can provide a useful reference for similar application.

  1. Intergalactic medium heating by dark matter

    NARCIS (Netherlands)

    Ripamonti, E.; Mapelli, M.; Ferrara, A.

    2006-01-01

    Abstract: We derive the evolution of the energy deposition in the intergalactic medium (IGM) by dark matter (DM) decays/annihilations for both sterile neutrinos and light dark matter (LDM) particles. At z > 200 sterile neutrinos transfer a fraction f_abs~0.5 of their rest mass energy into the IGM;

  2. T-1020 NaI crystal test for DM-Ice

    International Nuclear Information System (INIS)

    Maruyama, Reina; Heeger, Karsten; Pierpoint, Zachary; Pettus, Walter; Broerman, Benjamin; Hilgenberg, Chris; Webber, David

    2011-01-01

    This is a memorandum of understanding between the Fermi National Accelerator Laboratory (Fermilab) and the experiments of the NaI Crystal Test for DM-Ice from the University of Wisconsin who have committed to participate in detector tests to be carried out during the 2011-2012 Fermilab Neutrino program. The memorandum is intended primarily for the purpose of recording expectations for budget estimates and work allocations for Fermilab, the funding agencies and the participating institutions. It reflects an arrangement that currently is satisfactory to the parties; however, it is recognized and anticipated that changing circumstances of the evolving research program will necessitate revisions. The parties agree to modify this memorandum to reflect such required adjustments. Actual contractual obligations will be set forth in separate documents. The DM-Ice collaboration is designing a sodium-iodide (NaI) based detector for a direct dark matter search. The detectors should have low readout noise and background levels to carry out a sensitive search. A 17-kg version of the experiment is running at the South Pole, 2500 m deep in the Antarctic ice, and a large scale experiment is currently being designed. One of the keys to the success of the experiment is to have a good understanding of the background levels intrinsic in the NaI detectors. To measure the background level, the detectors have to be shielded against cosmic rays. The lead shielding used for DAMIC in the Minos Underground Areas is a well-suited location for this test since it offers enough overburden to shield against cosmic rays, lead shielding, and experimental infrastructure. The goal of the test is to assess the background levels in the detector and to assess the characteristics of phosphorescence induced by muons and 100 keV-3 MeV gamma rays.

  3. DARK MATTER ADMIXED TYPE Ia SUPERNOVAE

    International Nuclear Information System (INIS)

    Leung, S.-C.; Chu, M.-C.; Lin, L.-M.

    2015-01-01

    We perform two-dimensional hydrodynamic simulations for the thermonuclear explosion of Chandrasekhar-mass white dwarfs with dark matter (DM) cores in Newtonian gravity. We include a 19-isotope nuclear reaction network and make use of the pure turbulent deflagration model as the explosion mechanism in our simulations. Our numerical results show that the general properties of the explosion depend quite sensitively on the mass of the DM core M DM : a larger M DM generally leads to a weaker explosion and a lower mass of synthesized iron-peaked elements. In particular, the total mass of produced can drop from about 0.3 to 0.03 M ⊙ as M DM increases from 0.01 to 0.03 M ⊙ . We have also constructed the bolometric light curves obtained from our simulations and found that our results match well with the observational data of sub-luminous Type Ia supernovae

  4. Gamma-rays from decaying dark matter

    Energy Technology Data Exchange (ETDEWEB)

    Bertone, G. [Paris-6 Univ., 75 (France). Inst. d' Astrophysique; Buchmueller, W.; Covi, L.; Ibarra, A. [Deutsches Elektronen-Synchrotron (DESY), Hamburg (Germany)

    2007-10-15

    We study the prospects for detecting gamma-rays from decaying Dark Matter (DM), focusing in particular on gravitino DM in R-parity breaking vacua. Given the substantially different angular distribution of the predicted gamma-ray signal with respect to the case of annihilating DM, and the relatively poor (of order 0.1 ) angular resolution of gamma-ray detectors, the best strategy for detection is in this case to look for an exotic contribution to the gamma-ray flux at high galactic latitudes, where the decaying DM contribution would resemble an astrophysical extragalactic component, similar to the one inferred by EGRET observations. Upcoming experiments such as GLAST and AMS-02 may identify this exotic contribution and discriminate it from astrophysical sources, or place significant constraints on the mass and lifetime of DM particles. (orig.)

  5. Soft matter physics

    CERN Document Server

    Doi, Masao

    2013-01-01

    Soft matter (polymers, colloids, surfactants and liquid crystals) are an important class of materials in modern technology. They also form the basis of many future technologies, for example in medical and environmental applications. Soft matter shows complex behaviour between fluids and solids, and used to be a synonym of complex materials. Due to the developments of the past two decades, soft condensed matter can now be discussed on the same sound physical basis as solid condensedmatter. The purpose of this book is to provide an overview of soft matter for undergraduate and graduate students

  6. Direct detection of dark matter bound to the Earth

    DEFF Research Database (Denmark)

    Catena, Riccardo; Kouvaris, Chris

    2017-01-01

    We study the properties and direct detection prospects of an as of yet neglected population of dark matter (DM) particles moving in orbits gravitationally bound to the Earth. This DM population is expected to form via scattering by nuclei in the Earth's interior. We compute fluxes and nuclear...

  7. Impact of dark matter decays and annihilations on structure formation

    NARCIS (Netherlands)

    Mapelli, M.; Ripamonti, E.

    2007-01-01

    Abstract: We derived the evolution of the energy deposition in the intergalactic medium (IGM) by different decaying (or annihilating) dark matter (DM) candidates. Heavy annihilating DM particles (with mass larger than a few GeV) have no influence on reionization and heating, even if we assume that

  8. Impact of dark matter on reionization and heating

    NARCIS (Netherlands)

    Mapelli, M.; Ripamonti, E.

    2007-01-01

    Abstract: We derived the evolution of the energy deposition in the intergalactic medium (IGM) by different decaying (or annihilating) dark matter (DM) candidates. Heavy annihilating DM particles (with mass larger than a few GeV) have no influence on reionization and heating, even if we assume that

  9. Studying dark matter using weak gravitational lensing : from galaxies to the cosmic web

    NARCIS (Netherlands)

    Brouwer, M.M.

    2017-01-01

    Of all the mass in our Universe, 80% is thought to consist of a hypothetical and invisible substance called dark matter (DM). So far, all observations of DM are based on its gravitational interaction, either through the dynamics of normal (baryonic) matter or through the deflection of light.

  10. Dark Matter searches with the ATLAS Detector

    CERN Document Server

    Hooberman, Benjamin Henry; The ATLAS collaboration

    2016-01-01

    The presence of a non-baryonic Dark Matter (DM) component in the Universe is inferred from the observation of its gravitational interaction. If DM interacts non-gravitationally with the Standard Model, it could be produced at the LHC, escaping the detector and leaving missing transverse momentum (MET) as a signature. Recent results from the ATLAS detector will be presented, based on events with large MET accompanied by a variety of other objects.

  11. Characterizing Higgs portal dark matter models at the ILC

    Energy Technology Data Exchange (ETDEWEB)

    Kamon, Teruki [Texas A and M University, Department of Physics and Astronomy, Mitchell Institute for Fundamental Physics and Astronomy, College Station, TX (United States); Ko, P.; Li, Jinmian [Korea Institute for Advanced Study, School of Physics, Seoul (Korea, Republic of)

    2017-09-15

    We study the dark matter (DM) discovery prospect and its spin discrimination in the theoretical framework of gauge invariant and renormalizable Higgs portal DM models at the ILC with √(s) = 500 GeV. In such models, the DM pair is produced in association with a Z boson. In the case of the singlet scalar DM, the mediator is just the SM Higgs boson, whereas for the fermion or vector DM there is an additional singlet scalar mediator that mixes with the SM Higgs boson, which produces significant observable differences. After careful investigation of the signal and backgrounds both at parton level and at detector level, we find the signal with hadronically decaying Z boson provides a better search sensitivity than the signal with leptonically decaying Z boson. Taking the fermion DM model as a benchmark scenario, when the DM-mediator coupling g{sub χ} is relatively small, the DM signals are discoverable only for benchmark points with relatively light scalar mediator H{sub 2}. The spin discriminating from scalar DM is always promising, while it is difficult to discriminate from vector DM. As for g{sub χ} approaching the perturbative limit, benchmark points with the mediator H{sub 2} in the full mass region of interest are discoverable. The spin discriminating aspects from both the scalar and the fermion DM are quite promising. (orig.)

  12. Pulse shape analysis for germanium detectors used in DM searches

    International Nuclear Information System (INIS)

    Sagdeev, I.R.; Drukier, A.K.; Welsh, D.J.; Klimenko, A.A.; Osetrov, S.B.; Smolnikov, A.A.

    1994-01-01

    Progress in Ge detector technology has resulted in ultralow backgrounds of less than 0.3 countskeV -1 kg -1 d -1 at energies between 6 and 9keV and from 12 to 20keV. Between 4 and 6keV it is less than 2 countskeV -1 kg -1 d -1 . Coupled with good energy resolution, 0.4keV FWHM at 10keV, this allows searches for DM particles with m≥qslant8GeV/c 2 .Electromagnetic interference (EMI) and acoustical pick-up are the main sources of background in the best Ge detectors. A PC-based on-line pulse shape analysis system is presented which permits rejection of large fraction of the EMI/acoustical background. The hardware uses a low cost, commercially available digital storage oscilloscope (DSO). The software consists of about 40000 lines of code in Pascal and assembly language. We tested this system using a low radioactive background Ge-system at the Baksan observatory. For low energy events (<100keV) this system permits improvement in the background by about 20-30%. ((orig.))

  13. Strongly interacting light dark matter

    International Nuclear Information System (INIS)

    Bruggisser, Sebastian; Riva, Francesco; Urbano, Alfredo

    2016-07-01

    In the presence of approximate global symmetries that forbid relevant interactions, strongly coupled light Dark Matter (DM) can appear weakly coupled at small-energy and generate a sizable relic abundance. Fundamental principles like unitarity restrict these symmetries to a small class, where the leading interactions are captured by effective operators up to dimension-8. Chiral symmetry, spontaneously broken global symmetries and non-linearly realized supersymmetry are examples of this. Their DM candidates (composite fermions, pseudo-Nambu-Goldstone Bosons and Goldstini) are interesting targets for LHC missing-energy searches.

  14. DM100 AND DM1200 MELTER TESTING WITH HIGH WASTE LOADING GLASS FORMULATIONS FOR HANFORD HIGH-ALUMINUM HLW STREAMS

    Energy Technology Data Exchange (ETDEWEB)

    KRUGER AA; MATLACK KS; KOT WK; PEGG IL; JOSEPH I

    2009-12-30

    This Test Plan describes work to support the development and testing of high waste loading glass formulations that achieve high glass melting rates for Hanford high aluminum high level waste (HLW). In particular, the present testing is designed to evaluate the effect of using low activity waste (LAW) waste streams as a source of sodium in place ofchemical additives, sugar or cellulose as a reductant, boehmite as an aluminum source, and further enhancements to waste processing rate while meeting all processing and product quality requirements. The work will include preparation and characterization of crucible melts in support of subsequent DuraMelter 100 (DM 100) tests designed to examine the effects of enhanced glass formulations, glass processing temperature, incorporation of the LAW waste stream as a sodium source, type of organic reductant, and feed solids content on waste processing rate and product quality. Also included is a confirmatory test on the HLW Pilot Melter (DM1200) with a composition selected from those tested on the DM100. This work builds on previous work performed at the Vitreous State Laboratory (VSL) for Department of Energy's (DOE's) Office of River Protection (ORP) to increase waste loading and processing rates for high-iron HLW waste streams as well as previous tests conducted for ORP on the same waste composition. This Test Plan is prepared in response to an ORP-supplied statement of work. It is currently estimated that the number of HLW canisters to be produced in the Hanford Tank Waste Treatment and Immobilization Plant (WTP) is about 12,500. This estimate is based upon the inventory ofthe tank wastes, the anticipated performance of the sludge treatment processes, and current understanding of the capability of the borosilicate glass waste form. The WTP HLW melter design, unlike earlier DOE melter designs, incorporates an active glass bubbler system. The bubblers create active glass pool convection and thereby improve heat

  15. Asymmetric Dark Matter and Dark Radiation

    International Nuclear Information System (INIS)

    Blennow, Mattias; Martinez, Enrique Fernandez; Mena, Olga; Redondo, Javier; Serra, Paolo

    2012-01-01

    Asymmetric Dark Matter (ADM) models invoke a particle-antiparticle asymmetry, similar to the one observed in the Baryon sector, to account for the Dark Matter (DM) abundance. Both asymmetries are usually generated by the same mechanism and generally related, thus predicting DM masses around 5 GeV in order to obtain the correct density. The main challenge for successful models is to ensure efficient annihilation of the thermally produced symmetric component of such a light DM candidate without violating constraints from collider or direct searches. A common way to overcome this involves a light mediator, into which DM can efficiently annihilate and which subsequently decays into Standard Model particles. Here we explore the scenario where the light mediator decays instead into lighter degrees of freedom in the dark sector that act as radiation in the early Universe. While this assumption makes indirect DM searches challenging, it leads to signals of extra radiation at BBN and CMB. Under certain conditions, precise measurements of the number of relativistic species, such as those expected from the Planck satellite, can provide information on the structure of the dark sector. We also discuss the constraints of the interactions between DM and Dark Radiation from their imprint in the matter power spectrum

  16. Probing dark matter self-interaction in the Sun with IceCube-PINGU

    International Nuclear Information System (INIS)

    Chen, Chian-Shu; Lee, Fei-Fan; Lin, Guey-Lin; Lin, Yen-Hsun

    2014-01-01

    We study the capture, annihilation and evaporation of dark matter (DM) inside the Sun. It has been shown that the DM self-interaction can increase the DM number inside the Sun. We demonstrate that this enhancement becomes more significant in the regime of small DM mass, given a fixed DM self-interaction cross section. This leads to the enhancement of neutrino flux from DM annihilation. On the other hand, for DM mass as low as as a few GeVs, not only the DM-nuclei scatterings can cause the DM evaporation, DM self-interaction also provides non-negligible contributions to this effect. Consequently, the critical mass for DM evaporation (typically 3 ∼ 4 GeV without the DM self-interaction) can be slightly increased. We discuss the prospect of detecting DM self-interaction in IceCube-PINGU using the annihilation channels χχ → τ + τ - , νν-bar as examples. The PINGU sensitivities to DM self-interaction cross section σ χχ are estimated for track and cascade events

  17. Small Molecules that Enhance the Catalytic Efficiency of HLA-DM

    International Nuclear Information System (INIS)

    Nicholson, M.; Moradi, B.; Seth, N.; Xing, X.; Cuny, G.; Stein, R.; Wucherpfenning, K.

    2006-01-01

    HLA-DM (DM) plays a critical role in Ag presentation to CD4 T cells by catalyzing the exchange of peptides bound to MHC class II molecules. Large lateral surfaces involved in the DM:HLA-DR (DR) interaction have been defined, but the mechanism of catalysis is not understood. In this study, we describe four small molecules that accelerate DM-catalyzed peptide exchange. Mechanistic studies demonstrate that these small molecules substantially enhance the catalytic efficiency of DM, indicating that they make the transition state of the DM:DR/peptide complex energetically more favorable. These compounds fall into two functional classes: two compounds are active only in the presence of DM, and binding data for one show a direct interaction with DM. The remaining two compounds have partial activity in the absence of DM, suggesting that they may act at the interface between DM and DR/peptide. A hydrophobic ridge in the DMβ1 domain was implicated in the catalysis of peptide exchange because the activity of three of these enhancers was substantially reduced by point mutations in this area

  18. Search for Dark Matter produced in association with bottom quarks

    CERN Document Server

    CMS Collaboration

    2016-01-01

    This note describes a search for Dark Matter (DM) produced in association with b quarks, using a dataset of $2.17~\\mathrm{fb}^{-1}$ of data collected by the CMS experiment in $\\sqrt{s}=13~\\mathrm{TeV}$ proton-proton collisions at LHC. This analysis is sensitive also to DM production processes in association with top quarks. Results are reported as upper limits on the cross section for the b quark and top quark associated production independently, and interpreted within simplified models in terms of the coupling between the mediator and the DM candidate, for different mediator and DM candidate masses.

  19. Dark matter as a weakly coupled dark baryon

    Science.gov (United States)

    Mitridate, Andrea; Redi, Michele; Smirnov, Juri; Strumia, Alessandro

    2017-10-01

    Dark Matter might be an accidentally stable baryon of a new confining gauge interaction. We extend previous studies exploring the possibility that the DM is made of dark quarks heavier than the dark confinement scale. The resulting phenomenology contains new unusual elements: a two-stage DM cosmology (freeze-out followed by dark condensation), a large DM annihilation cross section through recombination of dark quarks (allowing to fit the positron excess). Light dark glue-balls are relatively long lived and give extra cosmological effects; DM itself can remain radioactive.

  20. Late kinetic decoupling of light magnetic dipole dark matter

    International Nuclear Information System (INIS)

    Gondolo, Paolo; Kadota, Kenji

    2016-01-01

    We study the kinetic decoupling of light (≲10 GeV) magnetic dipole dark matter (DM). We find that present bounds from collider, direct DM searches, and structure formation allow magnetic dipole DM to remain in thermal equilibrium with the early universe plasma until as late as the electron-positron annihilation epoch. This late kinetic decoupling leads to a minimal mass for the earliest dark protohalos of thousands of solar masses, in contrast to the conventional weak scale DM scenario where they are of order 10 −6 solar masses.

  1. Asymmetric Dark Matter Models and the LHC Diphoton Excess

    DEFF Research Database (Denmark)

    Frandsen, Mads T.; Shoemaker, Ian M.

    2016-01-01

    The existence of dark matter (DM) and the origin of the baryon asymmetry are persistent indications that the SM is incomplete. More recently, the ATLAS and CMS experiments have observed an excess of diphoton events with invariant mass of about 750 GeV. One interpretation of this excess is decays...... have for models of asymmetric DM that attempt to account for the similarity of the dark and visible matter abundances....

  2. Detecting Boosted Dark Matter from the Sun with Large Volume Neutrino Detectors

    Energy Technology Data Exchange (ETDEWEB)

    Berger, Joshua; /SLAC; Cui, Yanou; /Perimeter Inst. Theor. Phys.; Zhao, Yue; /Stanford U., ITP /Stanford U., Phys. Dept.

    2015-04-02

    We study novel scenarios where thermal dark matter (DM) can be efficiently captured in the Sun and annihilate into boosted dark matter. In models with semi-annihilating DM, where DM has a non-minimal stabilization symmetry, or in models with a multi-component DM sector, annihilations of DM can give rise to stable dark sector particles with moderate Lorentz boosts. We investigate both of these possibilities, presenting concrete models as proofs of concept. Both scenarios can yield viable thermal relic DM with masses O(1)-O(100) GeV. Taking advantage of the energetic proton recoils that arise when the boosted DM scatters off matter, we propose a detection strategy which uses large volume terrestrial detectors, such as those designed to detect neutrinos or proton decays. In particular, we propose a search for proton tracks pointing towards the Sun. We focus on signals at Cherenkov-radiation-based detectors such as Super-Kamiokande (SK) and its upgrade Hyper-Kamiokande (HK). We find that with spin-dependent scattering as the dominant DM-nucleus interaction at low energies, boosted DM can leave detectable signals at SK or HK, with sensitivity comparable to DM direct detection experiments while being consistent with current constraints. Our study provides a new search path for DM sectors with non-minimal structure.

  3. X-ray lines from dark matter: the good, the bad, and the unlikely

    Energy Technology Data Exchange (ETDEWEB)

    Frandsen, Mads T.; Sannino, Francesco; Shoemaker, Ian M.; Svendsen, Ole, E-mail: frandsen@cp3-origins.net, E-mail: sannino@cp3-origins.net, E-mail: shoemaker@cp3-origins.net, E-mail: svendsen@cp3-origins.net [CP" 3-Origins and Danish Institute for Advanced Study DIAS, University of Southern Denmark, Campusvej 55, DK-5230 Odense M (Denmark)

    2014-05-01

    We consider three classes of dark matter (DM) models to account for the recently observed 3.5 keV line: metastable excited state DM, annihilating DM, and decaying DM. We study two examples of metastable excited state DM. The first, millicharged composite DM, has both inelasticity and photon emission built in, but with a very constrained parameter space. In the second example, up-scattering and decay come from separate sectors and is thus less constrained. The decay of the excited state can potentially be detectable at direct detection experiments. However we find that CMB constraints are at the border of excluding this as an interpretation of the DAMA signal. The annihilating DM interpretation of the X-ray line is found to be in mild tension with CMB constraints. Lastly, a generalized version of decaying DM can account for the data with a lifetime exceeding the age of the Universe for masses ∼<10{sup 6} GeV.

  4. CP violating scalar Dark Matter

    Science.gov (United States)

    Cordero-Cid, A.; Hernández-Sánchez, J.; Keus, V.; King, S. F.; Moretti, S.; Rojas, D.; Sokołowska, D.

    2016-12-01

    We study an extension of the Standard Model (SM) in which two copies of the SM scalar SU(2) doublet which do not acquire a Vacuum Expectation Value (VEV), and hence are inert, are added to the scalar sector. We allow for CP-violation in the inert sector, where the lightest inert state is protected from decaying to SM particles through the conservation of a Z 2 symmetry. The lightest neutral particle from the inert sector, which has a mixed CP-charge due to CP-violation, is hence a Dark Matter (DM) candidate. We discuss the new regions of DM relic density opened up by CP-violation, and compare our results to the CP-conserving limit and the Inert Doublet Model (IDM). We constrain the parameter space of the CP-violating model using recent results from the Large Hadron Collider (LHC) and DM direct and indirect detection experiments.

  5. Dark matter (energy) may be indistinguishable from modified gravity (MOND)

    Science.gov (United States)

    Sivaram, C.

    For Newtonian dynamics to hold over galactic scales, large amounts of dark matter (DM) are required which would dominate cosmic structures. Accounting for the strong observational evidence that the universe is accelerating requires the presence of an unknown dark energy (DE) component constituting about 70% of the matter. Several ingenious ongoing experiments to detect the DM particles have so far led to negative results. Moreover, the comparable proportions of the DM and DE at the present epoch appear unnatural and not predicted by any theory. For these reasons, alternative ideas like MOND and modification of gravity or general relativity over cosmic scales have been proposed. It is shown in this paper that these alternate ideas may not be easily distinguishable from the usual DM or DE hypotheses. Specific examples are given to illustrate this point that the modified theories are special cases of a generalized DM paradigm.

  6. Constraining Non-thermal and Thermal properties of Dark Matter

    Directory of Open Access Journals (Sweden)

    Bhupal eDev

    2014-05-01

    Full Text Available We describe the evolution of Dark Matter (DM abundance from the very onset of its creation from inflaton decay under the assumption of an instantaneous reheating. Based on the initial conditions such as the inflaton mass and its decay branching ratio to the DM species, the reheating temperature, and the mass and interaction rate of the DM with the thermal bath, the DM particles can either thermalize (fully/partially with the primordial bath or remain non-thermal throughout their evolution history. In the thermal case, the final abundance is set by the standard freeze-out mechanism for large annihilation rates, irrespective of the initial conditions. For smaller annihilation rates, it can be set by the freeze-in mechanism which also does not depend on the initial abundance, provided it is small to begin with. For even smaller interaction rates, the DM decouples while being non-thermal, and the relic abundance will be essentially set by the initial conditions. We put model-independent constraints on the DM mass and annihilation rate from over-abundance by exactly solving the relevant Boltzmann equations, and identify the thermal freeze-out, freeze-in and non-thermal regions of the allowed parameter space. We highlight a generic fact that inflaton decay to DM inevitably leads to an overclosure of the Universe for a large range of DM parameter space, and thus poses a stringent constraint that must be taken into account while constructing models of DM. For the thermal DM region, we also show the complementary constraints from indirect DM search experiments, Big Bang Nucleosynthesis, Cosmic Microwave Background, Planck measurements, and theoretical limits due to the unitarity of S-matrix. For the non-thermal DM scenario, we show the allowed parameter space in terms of the inflaton and DM masses for a given reheating temperature, and compute the comoving free-streaming length to identify the hot, warm and cold DM regimes.

  7. Murværk opmuret med vådmørtler

    DEFF Research Database (Denmark)

    Hansen, Klavs Feilberg

    dmørtler benyttes i størstedelen af det murede nybyggeri. Egenskaberne af murværk opmuret med vådmørtel er i dag kun mangelfuldt dokumenteret. Denne rapport beskriver en metode til bedre dokumentation af de styrkemæssige egenskaber ved murværk opmuret med vådmørtel. Første del af rapporten genn...

  8. Dark matter electron anisotropy. A universal upper limit

    International Nuclear Information System (INIS)

    Borriello, Enrico; Maccione, Luca; Cuoco, Alessandro

    2010-12-01

    Indirect searches of particle Dark Matter (DM) with high energy Cosmic Rays (CR) are affected by large uncertainties, coming both from the DM side, and from poor understanding of the astrophysical backgrounds. We show that, on the contrary, the DM intrinsic degree of anisotropy in the arrival directions of high energy CR electrons and positrons does not suffer from these unknowns. Furthermore, if contributions from possible local sources are neglected, the intrinsic DM anisotropy sets the maximum degree of total anisotropy. As a consequence, if some anisotropy larger than the DM upper bound is detected, its origin could not be ascribed to DM, and would constitute an unambiguous evidence for the presence of astrophysical local discrete sources of high energy electrons and positrons. The Fermi-LAT will be able to probe such scenarios in the next years. (orig.)

  9. Hypothetical Dark Matter/Axion rockets: What can be said about Dark Matter in terms of space physics propulsion

    International Nuclear Information System (INIS)

    Beckwith, Andrew

    2009-01-01

    This paper discusses dark matter (DM) particle candidates from non-supersymmetry (SUSY) processes and explores how a DM candidate particle in the 100-400 GeV range could be created. Thrust from DM particles is also proposed for Photon rocket and Axion rockets. It would use a magnetic field to convert DM particles to near photonlike particles in a chamber to create thrust from the discharge of the near-photon-like particles. The presence of DM particles would suggest that thrust from the emerging near-photon-like particle would be greater than with conventional photon rockets. This amplifies and improves on an 'axion rocket ramjet' for interstellar travel. It is assumed that the same methodology used in an axion ramjet could be used with DM, with perhaps greater thrust/power conversion efficiencies.

  10. Multipartite interacting scalar dark matter in the light of updated LUX data

    Energy Technology Data Exchange (ETDEWEB)

    Bhattacharya, Subhaditya; Ghosh, Purusottam; Poulose, Poulose, E-mail: subhab@iitg.ernet.in, E-mail: p.ghosh@iitg.ernet.in, E-mail: poulose@iitg.ernet.in [Department of Physics, Indian Institute of Technology Guwahati, Guwahati, Assam 781039 (India)

    2017-04-01

    We explore constraints on multipartite dark matter (DM) framework composed of singlet scalar DM interacting with the Standard Model (SM) through Higgs portal coupling. We compute relic density and direct search constraints including the updated LUX bound for two component scenario with non-zero interactions between two DM components in Z{sub 2} × Z{sub 2}{sup '} framework in comparison with the one having O(2) symmetry. We point out availability of a significantly large region of parameter space of such a multipartite model with DM-DM interactions.

  11. SIGNATURES OF DARK MATTER BURNING IN NUCLEAR STAR CLUSTERS

    International Nuclear Information System (INIS)

    Casanellas, Jordi; Lopes, IlIdio

    2011-01-01

    In order to characterize how dark matter (DM) annihilation inside stars changes the aspect of a stellar cluster, we computed the evolution until the ignition of the He burning of stars from 0.7 M sun to 3.5 M sun within halos of DM with different characteristics. We found that, when a cluster is surrounded by a dense DM halo, the positions of the cluster' stars in the H-R diagram have a brighter and hotter turnoff point than in the classical scenario without DM, therefore giving the cluster a younger appearance. The high DM densities required to produce these effects are expected only in very specific locations, such as near the center of our Galaxy. In particular, if DM is formed by the 8 GeV weakly interacting massive particles recently invoked to reconcile the results from direct detection experiments, then this signature is predicted for halos of DM with a density ρ χ = 3 x 10 5 GeV cm -3 . A DM density gradient inside the stellar cluster would result in a broader main sequence, turnoff, and red giant branch regions. Moreover, we found that for very high DM halo densities the bottom of the isochrones in the H-R diagram rises to higher luminosities, leading to a characteristic signature on the stellar cluster. We argue that this signature could be used to indirectly probe the presence of DM particles in the location of a cluster.

  12. Twin Higgs Asymmetric Dark Matter.

    Science.gov (United States)

    García García, Isabel; Lasenby, Robert; March-Russell, John

    2015-09-18

    We study asymmetric dark matter (ADM) in the context of the minimal (fraternal) twin Higgs solution to the little hierarchy problem, with a twin sector with gauged SU(3)^{'}×SU(2)^{'}, a twin Higgs doublet, and only third-generation twin fermions. Naturalness requires the QCD^{'} scale Λ_{QCD}^{'}≃0.5-20  GeV, and that t^{'} is heavy. We focus on the light b^{'} quark regime, m_{b^{'}}≲Λ_{QCD}^{'}, where QCD^{'} is characterized by a single scale Λ_{QCD}^{'} with no light pions. A twin baryon number asymmetry leads to a successful dark matter (DM) candidate: the spin-3/2 twin baryon, Δ^{'}∼b^{'}b^{'}b^{'}, with a dynamically determined mass (∼5Λ_{QCD}^{'}) in the preferred range for the DM-to-baryon ratio Ω_{DM}/Ω_{baryon}≃5. Gauging the U(1)^{'} group leads to twin atoms (Δ^{'}-τ^{'}[over ¯] bound states) that are successful ADM candidates in significant regions of parameter space, sometimes with observable changes to DM halo properties. Direct detection signatures satisfy current bounds, at times modified by dark form factors.

  13. Comparative experimental and theoretical investigations of the DM neutron moisture probe

    DEFF Research Database (Denmark)

    Ølgaard, Povl Lebeck; Haahr, Vagner

    1967-01-01

    Theoretical and experimental investigations of the Danish produced DM subsurface moisture probe have been carried out at the Research Establishment Risö, and the results obtained are presented in this paper. The DM probe contains an Am-Be fast neutron source and has a glass scintillator containing...

  14. Hypertension and related risk factors in type 2 diabetes mellitus (DM ...

    African Journals Online (AJOL)

    Results: During the study it was found out that 61.2%of DM patients had hypertension, 56.4% obesity, 33.5% hypercholesterolemia and 38.9% hypertriglyceredemia. In the study, hypertension was associated with age, sex, type of DM, body mass index (BMI) and hypertriglyceredemia. Conclusion: The study found out that ...

  15. Draft Genome Sequence of Lactobacillus paracasei DmW181, a Bacterium Isolated from Wild Drosophila

    OpenAIRE

    Hammer, Austin J.; Walters, Amber; Carroll, Courtney; Newell, Peter D.; Chaston, John M.

    2017-01-01

    ABSTRACT The draft genome sequence of Lactobacillus paracasei DmW181, an anaerobic bacterium isolate from wild Drosophila flies, is reported here. Strain DmW181 possesses genes for sialic acid and mannose metabolism. The assembled genome is 3,201,429?bp, with 3,454 predicted genes.

  16. Draft Genome Sequence of Lactobacillus paracasei DmW181, a Bacterium Isolated from Wild Drosophila.

    Science.gov (United States)

    Hammer, Austin J; Walters, Amber; Carroll, Courtney; Newell, Peter D; Chaston, John M

    2017-07-06

    The draft genome sequence of Lactobacillus paracasei DmW181, an anaerobic bacterium isolate from wild Drosophila flies, is reported here. Strain DmW181 possesses genes for sialic acid and mannose metabolism. The assembled genome is 3,201,429 bp, with 3,454 predicted genes. Copyright © 2017 Hammer et al.

  17. Prevalence of type 2 diabetes mellitus complications among palestinians with T2DM

    DEFF Research Database (Denmark)

    Abu Al-Halaweh, Ahmad; Davidovitch, Nadav; Almdal, Thomas Peter

    2017-01-01

    AIMS: To assess the prevalence of microvascular and macrovascular complications of type 2 diabetes (T2DM) among Palestinians. METHODS: 1308 diagnosed T2DM attending four main Primary Health Care Clinics on the Southern West Bank of Palestine examined by a Mobile Diabetes Clinic team. All diabetes...

  18. Simplified models of mixed dark matter

    International Nuclear Information System (INIS)

    Cheung, Clifford; Sanford, David

    2014-01-01

    We explore simplified models of mixed dark matter (DM), defined here to be a stable relic composed of a singlet and an electroweak charged state. Our setup describes a broad spectrum of thermal DM candidates that can naturally accommodate the observed DM abundance but are subject to substantial constraints from current and upcoming direct detection experiments. We identify ''blind spots'' at which the DM-Higgs coupling is identically zero, thus nullifying direct detection constraints on spin independent scattering. Furthermore, we characterize the fine-tuning in mixing angles, i.e. well-tempering, required for thermal freeze-out to accommodate the observed abundance. Present and projected limits from LUX and XENON1T force many thermal relic models into blind spot tuning, well-tempering, or both. This simplified model framework generalizes bino-Higgsino DM in the MSSM, singlino-Higgsino DM in the NMSSM, and scalar DM candidates that appear in models of extended Higgs sectors

  19. Particle dark matter: A multimessenger endeavour

    Science.gov (United States)

    Regis, M.

    2017-01-01

    The search for dark matter (DM) as a new, yet undiscovered, particle is explored through a complex host of different signals, from collider to direct and indirect searches. A special focus is dedicated to the latter ones, covering the full electromagnetic spectrum (from radio to gamma-rays), charged cosmic-rays and neutrinos. The expected DM signals are by definition faint, but the possibility to exploit a wide-field investigation offers promising prospects. In this brief review, I summarize the state-of-the-art in the search for particle DM signals, exploring some new ideas that are emerging in the effort of the scientific community to understand the elusive nature of DM.

  20. Cosmological implications of Dark Matter bound states

    Energy Technology Data Exchange (ETDEWEB)

    Mitridate, Andrea [Scuola Normale Superiore, Piazza dei Cavalieri 7, 56126, Pisa (Italy); Redi, Michele; Smirnov, Juri [INFN, Sezione di Firenze, and Dipartimento di Fisica e Astronomia, Università di Firenze, Via G. Sansone 1, 50019 Sesto Fiorentino (Italy); Strumia, Alessandro, E-mail: andrea.mitridate@gmail.com, E-mail: michele.redi@fi.infn.it, E-mail: juri.smirnov@mpi-hd.mpg.de, E-mail: alessandro.strumia@cern.ch [Dipartimento di Fisica dell' Università di Pisa and INFN, Pisa (Italy)

    2017-05-01

    We present generic formulæ for computing how Sommerfeld corrections together with bound-state formation affects the thermal abundance of Dark Matter with non-abelian gauge interactions. We consider DM as a fermion 3plet (wino) or 5plet under SU(2) {sub L} . In the latter case bound states raise to 11.5 TeV the DM mass required to reproduce the cosmological DM abundance and give indirect detection signals such as (for this mass) a dominant γ-line around 70 GeV. Furthermore, we consider DM co-annihilating with a colored particle, such as a squark or a gluino, finding that bound state effects are especially relevant in the latter case.

  1. Attitudes and barriers to exercise in adults with type 1 diabetes (T1DM and how best to address them: a qualitative study.

    Directory of Open Access Journals (Sweden)

    Nadia Lascar

    Full Text Available Regular physical activity has recognised health benefits for people with T1DM. However a significant proportion of them do not undertake the recommended levels of activity. Whilst questionnaire-based studies have examined barriers to exercise in people with T1DM, a formal qualitative analysis of these barriers has not been undertaken. Our aims were to explore attitudes, barriers and facilitators to exercise in patients with T1DM.A purposeful sample of long standing T1DM patients were invited to participate in this qualitative study. Twenty-six adults were interviewed using a semi-structured interview schedule to determine their level of exercise and barriers to initiation and maintenance of an exercise programme.Six main barriers to exercise were identified: lack of time and work related factors; access to facilities; lack of motivation; embarrassment and body image; weather; and diabetes specific barriers (low levels of knowledge about managing diabetes and its complications around exercise. Four motivators to exercise were identified: physical benefits from exercise; improvements in body image; enjoyment and the social interaction of exercising at gym or in groups. Three facilitators to exercise were identified: free or reduced admission to gyms and pools, help with time management, and advice and encouragement around managing diabetes for exercise.Many of the barriers to exercise in people with T1DM are shared with the non-diabetic population. The primary difference is the requirement for education about the effect of exercise on diabetes control and its complications. There was a preference for support to be given on a one to one basis rather than in a group environment. This suggests that with the addition of the above educational requirements, one to one techniques that have been successful in increasing activity in patients with other chronic disease and the general public should be successful in increasing activity in patients with T1DM.

  2. Attitudes and barriers to exercise in adults with type 1 diabetes (T1DM) and how best to address them: a qualitative study.

    Science.gov (United States)

    Lascar, Nadia; Kennedy, Amy; Hancock, Beverley; Jenkins, David; Andrews, Robert C; Greenfield, Sheila; Narendran, Parth

    2014-01-01

    Regular physical activity has recognised health benefits for people with T1DM. However a significant proportion of them do not undertake the recommended levels of activity. Whilst questionnaire-based studies have examined barriers to exercise in people with T1DM, a formal qualitative analysis of these barriers has not been undertaken. Our aims were to explore attitudes, barriers and facilitators to exercise in patients with T1DM. A purposeful sample of long standing T1DM patients were invited to participate in this qualitative study. Twenty-six adults were interviewed using a semi-structured interview schedule to determine their level of exercise and barriers to initiation and maintenance of an exercise programme. Six main barriers to exercise were identified: lack of time and work related factors; access to facilities; lack of motivation; embarrassment and body image; weather; and diabetes specific barriers (low levels of knowledge about managing diabetes and its complications around exercise). Four motivators to exercise were identified: physical benefits from exercise; improvements in body image; enjoyment and the social interaction of exercising at gym or in groups. Three facilitators to exercise were identified: free or reduced admission to gyms and pools, help with time management, and advice and encouragement around managing diabetes for exercise. Many of the barriers to exercise in people with T1DM are shared with the non-diabetic population. The primary difference is the requirement for education about the effect of exercise on diabetes control and its complications. There was a preference for support to be given on a one to one basis rather than in a group environment. This suggests that with the addition of the above educational requirements, one to one techniques that have been successful in increasing activity in patients with other chronic disease and the general public should be successful in increasing activity in patients with T1DM.

  3. Interference effects of two scalar boson propagators on the LHC search for the singlet fermion DM

    Energy Technology Data Exchange (ETDEWEB)

    Ko, P., E-mail: pko@kias.re.kr; Li, Jinmian, E-mail: jmli@kias.re.kr

    2017-02-10

    A gauge invariant UV-completion for singlet fermion DM interacting with the standard model (SM) particles involves a new singlet scalar. Therefore the model contains two scalar mediators, mixtures of the SM Higgs boson and a singlet scalar boson. Collider phenomenology of the interference effect between these two scalar propagators is studied in this work. This interference effect can be either constructive or destructive in the DM production cross section depending on both singlet scalar and DM masses, and it will soften the final state jets in the full mass region. Applying the CMS mono-jet search to our model, we find the interference effect plays a very important role in the DM search sensitivity, and the DM production cross section of our model is more than one order of magnitude below the LHC sensitivity at current stage.

  4. Direct and Indirect Dark Matter Detection in Gauge Theories

    Energy Technology Data Exchange (ETDEWEB)

    Queiroz, Farinaldo [Federal Univ. of Paraba (Brazil)

    2013-01-01

    The Dark matter (DM) problem constitutes a key question at the interface among Particle Physics, Astrophysics and Cosmology. The observational data which have been accumulated in the last years point to an existence of non baryonic amount of DM. Since the Standard Model (SM) does not provide any candidate for such non-baryonic DM, the evidence of DM is a major indication for new physics beyond the SM. We will study in this work one of the most popular DM candidates, the so called WIMPs (Weakly Interacting Massive Particles) from a direct and indirect detection perspective. In order to approach the direct and indirect dection of DM in the context of Particle Physics in a more pedagogic way, we will begin our discussion talking about a minimal extension of the SM. Later we will work on the subject in a 3-3-1 model. Next, we will study the role of WIMPs in the Big Bang Nucleosynthesis. Lastly, we will look for indirect DM signals in the center of our galaxy using the NASA Satellite, called Fermi-LAT. Through a comprehensive analysis of the data events observed by Fermi-LAT and some background models, we will constrain the dark matter annihilation cross section for several annihilation channels and dark matter halo profiles.

  5. Dark matter as the signal of grand unification

    International Nuclear Information System (INIS)

    Kadastik, Mario; Kannike, Kristjan; Raidal, Martti

    2009-01-01

    We argue that the existence of dark matter (DM) is a possible consequence of grand unification (GUT) symmetry breaking. In GUTs like SO(10), discrete Z 2 matter parity (-1) 3(B-L) survives despite broken B-L, and group theory uniquely determines that the only possible Z 2 -odd matter multiplets belong to representation 16. We construct the minimal nonsupersymmetric SO(10) model containing one scalar 16 for DM and study its predictions below M G . We find that electroweak symmetry breaking occurs radiatively due to DM couplings to the standard model Higgs boson. For thermal relic DM the mass range M DM ∼O(0.1-1) TeV is predicted by model perturbativity up to M G . For M DM ∼O(1) TeV to explain the observed cosmic ray anomalies with DM decays, there exists a lower bound on the spin-independent direct detection cross section within the reach of planned experiments.

  6. Supersymmetry, Dark Matter and the LHC

    International Nuclear Information System (INIS)

    Tata, Xerxes

    2010-01-01

    The conceptually simplest scenario for dark matter (DM) is that it is a stable thermal relic from standard Big Bang cosmology, in many SUSY models the lightest neutralino. The relic density determination selects special regions in SUSY model parameter space with concomitant implications for collider physics, dark matter searches and low energy measurements. By studying various one-parameter extensions of the much-studied mSUGRA model (where we relax the untested universality assumptions) constructed to be in accord with the measured relic density, we show that these implications are in general model-dependent, so that LHC and DM measurements will provide clues to how sparticles acquire their masses. We point out some relatively robust implications for LHC and DM searches and conclude with an outlook for the future.

  7. Exploring dark matter microphysics with galaxy surveys

    Energy Technology Data Exchange (ETDEWEB)

    Escudero, Miguel; Mena, Olga [Instituto de Física Corpuscular (IFIC), CSIC-Universitat de València, Apartado de Correos 22085, E-46071 Valencia (Spain); Vincent, Aaron C.; Wilkinson, Ryan J.; Boehm, Céline, E-mail: miguel.Escudero@uv.es, E-mail: omena@ific.uv.es, E-mail: aaron.vincent@durham.ac.uk, E-mail: ryan.wilkinson@durham.ac.uk, E-mail: c.m.boehm@durham.ac.uk [Institute for Particle Physics Phenomenology (IPPP), Durham University, South Road, Durham DH1 3LE (United Kingdom)

    2015-09-01

    We use present cosmological observations and forecasts of future experiments to illustrate the power of large-scale structure (LSS) surveys in probing dark matter (DM) microphysics and unveiling potential deviations from the standard ΛCDM scenario. To quantify this statement, we focus on an extension of ΛCDM with DM-neutrino scattering, which leaves a distinctive imprint on the angular and matter power spectra. After finding that future CMB experiments (such as COrE+) will not significantly improve the constraints set by the Planck satellite, we show that the next generation of galaxy clustering surveys (such as DESI) could play a leading role in constraining alternative cosmologies and even have the potential to make a discovery. Typically we find that DESI would be an order of magnitude more sensitive to DM interactions than Planck, thus probing effects that until now have only been accessible via N-body simulations.

  8. The dark matter density in the solar neighborhood reconsidered

    Energy Technology Data Exchange (ETDEWEB)

    Boer, W. de; Weber, M., E-mail: wim.de.boer@kit.edu, E-mail: mj.weber@kit.edu [Institut für Experimentelle Kernphysik, Karlsruher Institut für Technologie (KIT), P.O. Box 6980, 76128 Karlsruhe (Germany)

    2011-04-01

    The peculiar dip in the outer rotation curve at a distance of 9 kpc, which was recently confirmed by precise measurements with the VERA VLBI array in Japan, suggests donut-like substructures in the dark matter (DM) halo, since spherical or elliptical distributions will not cause a dip. Additionally, such a donut-like DM structure seems to be required by the dip in the gas flaring of the disk. In this paper we consider the impact of such DM substructure in the disk on the rotation curve, the gas flaring, the local DM density and the local surface density. A global fit shows that the rotation curve is best described by an NFW DM profile complemented by two donut-like DM substructures at radii of 4.2 and 12.4 kpc, which coincide with the local dust ring and the Monocerus ring of stars, respectively. Both regions have been suggested as regions with tidal streams from ''shredded'' satellites, thus enhancing the plausibility for additional DM. If real, the radial extensions of these nearby ringlike structures enhance the local dark matter density by a factor of four to about 1.3±0.3 GeV/cm{sup 3}. We find that i) this higher DM density is perfectly consistent with the local gravitational potential determining the surface density and ii) the s-shaped gas flaring is explained. Such a possible enhancement of the local DM density is of great interest for direct DM searches and the ringlike structure would change the directional dependence of gamma rays for indirect DM searches.

  9. Light Readout for a 1 ton Liquid Argon Dark Matter Detector

    CERN Document Server

    Boccone, Vittorio; Baudis, Laura; Otyugova, Polina; Regenfus, Christian

    2010-01-01

    Evidence for dark matter (DM) has been reported using astronomical observations in systems such as the Bullet cluster. Weakly interactive massive particles (WIMPs), in particular the lightest neutralino, are the most popular DM candidates within the Minimal Supersymmetric Standard Model (MSSM). Many groups in the world are focussing their attention on the direct detection of DM in the laboratory. The detectors should have large target masses and excellent noise rejection capabilities because of the small cross section between DM and ordinary matter (σWIMP−nucleon < 4 · 10−8 pb). Noble liquids are today considered to be one of the best options for large-size DM experiments, as they have a relatively low ionization energy, good scintillation properties and long electron lifetime. Moreover noble liquid detectors are easily scalable to large masses. This thesis deals with the development of a large (1 ton) LAr WIMP detector (ArDM) which could measure simultaneously light and charge from the scintilla...

  10. Heterologous expression of the antimyotoxic protein DM64 in Pichia pastoris.

    Directory of Open Access Journals (Sweden)

    Saulo Martins Vieira

    2017-07-01

    Full Text Available Snakebite envenomation is a neglected condition that constitutes a public health problem in tropical and subtropical countries, including Brazil. Interestingly, some animals are resistant to snake envenomation due to the presence of inhibitory glycoproteins in their serum that target toxic venom components. DM64 is an acidic glycoprotein isolated from Didelphis aurita (opossum serum that has been characterized as an inhibitor of the myotoxicity induced by bothropic toxins bearing phospholipase A2 (PLA2 structures. This antitoxic protein can serve as an excellent starting template for the design of novel therapeutics against snakebite envenomation, particularly venom-induced local tissue damage. Therefore, the aim of this work was to produce a recombinant DM64 (rDM64 in the methylotrophic yeast Pichia pastoris and to compare its biological properties with those of native DM64. Yeast fermentation in the presence of Pefabloc, a serine protease inhibitor, stimulated cell growth (~1.5-fold, increased the rDM64 production yield approximately 10-fold and significantly reduced the susceptibility of rDM64 to proteolytic degradation. P. pastoris fermentation products were identified by mass spectrometry and Western blotting. The heterologous protein was efficiently purified from the culture medium by affinity chromatography (with immobilized PLA2 myotoxin and/or an ion exchange column. Although both native and recombinant DM64 exhibit different glycosylation patterns, they show very similar electrophoretic mobilities after PNGase F treatment. rDM64 formed a noncovalent complex with myotoxin II (Lys49-PLA2 from Bothrops asper and displayed biological activity that was similar to that of native DM64, inhibiting the cytotoxicity of myotoxin II by 92% at a 1:1 molar ratio.

  11. Dm5-HT2B: Pharmacological Characterization of the Fifth Serotonin Receptor Subtype of Drosophila melanogaster

    Directory of Open Access Journals (Sweden)

    Wolfgang Blenau

    2017-05-01

    Full Text Available Serotonin (5-hydroxytryptamine, 5-HT is an important regulator of physiological and behavioral processes in both protostomes (e.g., insects and deuterostomes (e.g., mammals. In insects, serotonin has been found to modulate the heart rate and to control secretory processes, development, circadian rhythms, aggressive behavior, as well as to contribute to learning and memory. Serotonin exerts its activity by binding to and activating specific membrane receptors. The clear majority of these receptors belong to the superfamily of G-protein-coupled receptors. In Drosophila melanogaster, a total of five genes have been identified coding for 5-HT receptors. From this family of proteins, four have been pharmacologically examined in greater detail, so far. While Dm5-HT1A, Dm5-HT1B, and Dm5-HT7 couple to cAMP signaling cascades, the Dm5-HT2A receptor leads to Ca2+ signaling in an inositol-1,4,5-trisphosphate-dependent manner. Based on sequence similarity to homologous genes in other insects, a fifth D. melanogaster gene was uncovered coding for a Dm5-HT2B receptor. Knowledge about this receptor’s pharmacological properties is very limited. This is quite surprising because Dm5-HT2B has been attributed to distinct physiological functions based on genetic interference with its gene expression. Mutations were described reducing the response of the larval heart to 5-HT, and specific knockdown of Dm5-HT2B mRNA in hemocytes resulted in a higher susceptibility of the flies to bacterial infection. To gain deeper understanding of Dm5-HT2B’s pharmacology, we evaluated the receptor’s response to a series of established 5-HT receptor agonists and antagonists in a functional cell-based assay. Metoclopramide and mianserin were identified as two potent antagonists that may allow pharmacological interference with Dm5-HT2B signaling in vitro and in vivo.

  12. Dm5-HT2B: Pharmacological Characterization of the Fifth Serotonin Receptor Subtype of Drosophila melanogaster.

    Science.gov (United States)

    Blenau, Wolfgang; Daniel, Stöppler; Balfanz, Sabine; Thamm, Markus; Baumann, Arnd

    2017-01-01

    Serotonin (5-hydroxytryptamine, 5-HT) is an important regulator of physiological and behavioral processes in both protostomes (e.g., insects) and deuterostomes (e.g., mammals). In insects, serotonin has been found to modulate the heart rate and to control secretory processes, development, circadian rhythms, aggressive behavior, as well as to contribute to learning and memory. Serotonin exerts its activity by binding to and activating specific membrane receptors. The clear majority of these receptors belong to the superfamily of G-protein-coupled receptors. In Drosophila melanogaster , a total of five genes have been identified coding for 5-HT receptors. From this family of proteins, four have been pharmacologically examined in greater detail, so far. While Dm5-HT 1A , Dm5-HT 1B , and Dm5-HT 7 couple to cAMP signaling cascades, the Dm5-HT 2A receptor leads to Ca 2+ signaling in an inositol-1,4,5-trisphosphate-dependent manner. Based on sequence similarity to homologous genes in other insects, a fifth D. melanogaster gene was uncovered coding for a Dm5-HT 2B receptor. Knowledge about this receptor's pharmacological properties is very limited. This is quite surprising because Dm5-HT 2B has been attributed to distinct physiological functions based on genetic interference with its gene expression. Mutations were described reducing the response of the larval heart to 5-HT, and specific knockdown of Dm5-HT 2B mRNA in hemocytes resulted in a higher susceptibility of the flies to bacterial infection. To gain deeper understanding of Dm5-HT 2B 's pharmacology, we evaluated the receptor's response to a series of established 5-HT receptor agonists and antagonists in a functional cell-based assay. Metoclopramide and mianserin were identified as two potent antagonists that may allow pharmacological interference with Dm5-HT 2B signaling in vitro and in vivo .

  13. Singlet fermionic dark matter with Veltman conditions

    OpenAIRE

    Kim, Yeong Gyun; Lee, Kang Young; Nam, Soo-hyeon

    2018-01-01

    We reexamine a renormalizable model of a fermionic dark matter with a gauge singlet Dirac fermion and a real singlet scalar which can ameliorate the scalar mass hierarchy problem of the Standard Model (SM). Our model setup is the minimal extension of the SM for which a realistic dark matter (DM) candidate is provided and the cancellation of one-loop quadratic divergence to the scalar masses can be achieved by the Veltman condition (VC) simultaneously. This model extension, although renormaliz...

  14. Particle dark matter - A theorist's perspective

    Indian Academy of Sciences (India)

    ture of the dark matter (DM) in the Universe, from the point of view of particle ... they must be electrically and (preferably) color neutral. .... in the general MssM and in two unification-based models: the constrained MssM ..... multi-TeV range.

  15. Quantifying Matter

    CERN Document Server

    Angelo, Joseph A

    2011-01-01

    Quantifying Matter explains how scientists learned to measure matter and quantify some of its most fascinating and useful properties. It presents many of the most important intellectual achievements and technical developments that led to the scientific interpretation of substance. Complete with full-color photographs, this exciting new volume describes the basic characteristics and properties of matter. Chapters include:. -Exploring the Nature of Matter. -The Origin of Matter. -The Search for Substance. -Quantifying Matter During the Scientific Revolution. -Understanding Matter's Electromagnet

  16. Cosmological axion and a quark nugget dark matter model

    Science.gov (United States)

    Ge, Shuailiang; Liang, Xunyu; Zhitnitsky, Ariel

    2018-02-01

    We study a dark matter (DM) model offering a very natural explanation of two (naively unrelated) problems in cosmology: the observed relation ΩDM˜Ωvisible and the observed asymmetry between matter and antimatter in the Universe, known as the "baryogenesis" problem. In this framework, both types of matter (dark and visible) have the same QCD origin, form at the same QCD epoch, and are proportional to one and the same dimensional parameter of the system, ΛQCD, which explains how these two naively distinct problems could be intimately related, and could be solved simultaneously within the same framework. More specifically, the DM in this model is composed by two different ingredients: the (well-studied) DM axions and the (less-studied) quark nuggets made of matter or antimatter. We focus on the quantitative analysis of the relation between these two distinct components contributing to the dark sector of the theory determined by ΩDM≡[ΩDM(nuggets)+ΩDM(axion)] . We argue that the nuggets' DM component always traces the visible matter density, i.e., ΩDM(nuggets)˜Ωvisible , and this feature is not sensitive to the parameters of the system such as the axion mass ma or the misalignment angle θ0. It should be contrasted with conventional axion production mechanisms due to the misalignment when ΩDM(axion) is highly sensitive to the axion mass ma and the initial misalignment angle θ0. We also discuss the constraints on this model related to the inflationary scale HI, nonobservation of the isocurvature perturbations and the tensor modes. We also comment on some constraints related to various axion search experiments.

  17. PPPC 4 DMν: a Poor Particle Physicist Cookbook for Neutrinos from Dark Matter annihilations in the Sun

    International Nuclear Information System (INIS)

    Baratella, Pietro; Cirelli, Marco; Hektor, Andi; Pata, Joosep; Piibeleht, Morten; Strumia, Alessandro

    2014-01-01

    We provide ingredients and recipes for computing neutrino signals of TeV-scale Dark Matter (DM) annihilations in the Sun. For each annihilation channel and DM mass we present the energy spectra of neutrinos at production, including: state-of-the-art energy losses of primary particles in solar matter, secondary neutrinos, electroweak radiation. We then present the spectra after propagation to the Earth, including (vacuum and matter) flavor oscillations and interactions in solar matter. We also provide a numerical computation of the capture rate of DM particles in the Sun. These results are available in numerical form http://www.marcocirelli.net/PPPC4DMID.html

  18. PPPC 4 DMν: a Poor Particle Physicist Cookbook for Neutrinos from Dark Matter annihilations in the Sun

    Energy Technology Data Exchange (ETDEWEB)

    Baratella, Pietro [Scuola Normale Superiore and INFN, Piazza dei Cavalieri 7, Pisa, 56126 (Italy); Cirelli, Marco [Institut de Physique Théorique, CNRS URA 2306 and CEA-Saclay, Gif-sur-Yvette, 91191 (France); Hektor, Andi; Pata, Joosep; Piibeleht, Morten; Strumia, Alessandro, E-mail: pietro.baratella@sissa.it, E-mail: marco.cirelli@cea.fr, E-mail: andi.hektor@cern.ch, E-mail: joosep.pata@cern.ch, E-mail: morten.piibeleht@cern.ch, E-mail: alessandro.strumia@cern.ch [National Institute of Chemical Physics and Biophysics, Ravala 10, Tallinn (Estonia)

    2014-03-01

    We provide ingredients and recipes for computing neutrino signals of TeV-scale Dark Matter (DM) annihilations in the Sun. For each annihilation channel and DM mass we present the energy spectra of neutrinos at production, including: state-of-the-art energy losses of primary particles in solar matter, secondary neutrinos, electroweak radiation. We then present the spectra after propagation to the Earth, including (vacuum and matter) flavor oscillations and interactions in solar matter. We also provide a numerical computation of the capture rate of DM particles in the Sun. These results are available in numerical form.

  19. PPPC 4 DMν: a Poor Particle Physicist Cookbook for Neutrinos from Dark Matter annihilations in the Sun

    Energy Technology Data Exchange (ETDEWEB)

    Baratella, Pietro [Scuola Normale Superiore and INFN, Piazza dei Cavalieri 7, Pisa, 56126 (Italy); Cirelli, Marco [Institut de Physique Théorique, CNRS URA 2306 & CEA-Saclay, Gif-sur-Yvette, 91191 (France); Hektor, Andi [National Institute of Chemical Physics and Biophysics, Ravala 10, Tallinn (Estonia); Helsinki Institute of Physics, P.O. Box 64, Helsinki, FI-00014 (Finland); Pata, Joosep; Piibeleht, Morten [National Institute of Chemical Physics and Biophysics, Ravala 10, Tallinn (Estonia); Strumia, Alessandro [National Institute of Chemical Physics and Biophysics, Ravala 10, Tallinn (Estonia); Dipartimento di Fisica dell’Università di Pisa and INFN, Largo Buonarroti 2, Pisa (Italy)

    2014-03-27

    We provide ingredients and recipes for computing neutrino signals of TeV-scale Dark Matter (DM) annihilations in the Sun. For each annihilation channel and DM mass we present the energy spectra of neutrinos at production, including: state-of-the-art energy losses of primary particles in solar matter, secondary neutrinos, electroweak radiation. We then present the spectra after propagation to the Earth, including (vacuum and matter) flavor oscillations and interactions in solar matter. We also provide a numerical computation of the capture rate of DM particles in the Sun. These results are available in numerical form http://www.marcocirelli.net/PPPC4DMID.html.

  20. C-Peptide Is Independently Associated with an Increased Risk of Coronary Artery Disease in T2DM Subjects: A Cross-Sectional Study.

    Directory of Open Access Journals (Sweden)

    Lingshu Wang

    Full Text Available C-peptide has been reported to be a marker of subclinical atherosclerosis in type 2 diabetes mellitus (T2DM patients, whereas its role in coronary artery disease (CAD has not been clarified, especially in diabetics with differing body mass indices (BMIs.This cross-sectional study included 501 patients with T2DM. First, all subjects were divided into the following two groups: CAD and non-CAD. Then, binary logistic regression was used to determine the risk factors for CAD for all patients. To clarify the role of obesity, we re-divided all subjects into two additional groups (obese and non-obese based on BMI. Finally, binary logistic regression was used to determine the risk factors for CAD for each weight group.The patients with CAD showed a higher BMI and fasting C-peptide level in addition to an increased prevalence of traditional risk factors for CAD, such as hypertension, insulin resistance, higher cholesterol, cysteine-C (Cys-C and lower estimated glomerular filtration rate (eGFR. Logistic regression analysis showed that fasting C-peptide (OR=1.513, p=0.005, insulin treatment (OR=1.832, p=0.027 hypertension (OR=1.987, p=0.016 and hyperlipidemia (OR=4.159, p<0.001 significantly increased the risk of clinical CAD in the T2DM patients independent of age, gender, diabetes duration, smoking and alcohol statuses, fasting insulin and glucose, hypoglycemic episodes, UA and eGFR. Additionally, in both of the obese (OR=1.488, p=0.049 and non-obese (OR=1.686, p=0.037 DM groups, C-peptide was associated with an increased risk of CAD after multiple adjustments.C-peptide is associated with an increased CAD risk in T2DM patients, no matter whether they are obese or not.

  1. Studies on the s_dm.t=f verb form in Classical Egyptian

    OpenAIRE

    Zonhoven, Ludovicus Martinus Johannes

    1997-01-01

    This study is devoted to some synchronic aspects of the sDm.t=f verb form, primarily its meaning and uses in Classical Egyptian. In the introduction some attention is paid to the history of the studies of the form and its origin, an aspect which will receive no further consideration. In accordance with present common opinion the sDm.t=f is here considered to belong to the suffix conjugation. Ch. I is primarily concerned with the active Dr sDm.t=f construction, but begins with a general introd...

  2. Cancellation Mechanism for Dark-Matter-Nucleon Interaction.

    Science.gov (United States)

    Gross, Christian; Lebedev, Oleg; Toma, Takashi

    2017-11-10

    We consider a simple Higgs portal dark-matter model, where the standard model is supplemented with a complex scalar whose imaginary part plays the role of weakly interacting massive particle dark matter (DM). We show that the direct DM detection cross section vanishes at the tree level and zero momentum transfer due to a cancellation by virtue of a softly broken symmetry. This cancellation is operative for any mediator masses. As a result, our electroweak-scale dark matter satisfies all of the phenomenological constraints quite naturally.

  3. Constraining Dark Matter using Mono-X, Dijet, and Dilepton Final States with the ATLAS Detector

    CERN Document Server

    Tolley, Emma; The ATLAS collaboration

    2017-01-01

    Weakly-coupled TeV-scale particles may mediate interactions between dark matter (DM) and Standard Model (SM) particles. DM production at colliders may be evident in “mono-X” topologies, and mediator production in in dijet and dilepton events. The latest results obtained by the ATLAS experiment are presented and interpreted following the LHC DM WG guidelines, with particular focus on the complementarity between different collider searches as well as direct detection experiments.

  4. Dark matter physics, flavor physics and LHC constraints in the dark matter model with a bottom partner

    Energy Technology Data Exchange (ETDEWEB)

    Abe, Tomohiro [Institute for Advanced Research, Nagoya University,Nagoya 464-8602 (Japan); Kobayashi-Maskawa Institute for the Origin of Particles and the Universe,Nagoya University, Nagoya 464-8602 (Japan); Kawamura, Junichiro [Department of Physics, Waseda University,Tokyo 169-8555 (Japan); Okawa, Shohei [Department of Physics, Nagoya University,Nagoya 464-8602 (Japan); Omura, Yuji [Kobayashi-Maskawa Institute for the Origin of Particles and the Universe,Nagoya University, Nagoya 464-8602 (Japan)

    2017-03-10

    In the scenario that dark matter (DM) is a weakly interacting massive particle, there are many possibilities of the interactions with the Standard Model (SM) particles to achieve the relic density of DM. In this paper, we consider a simple DM model where the DM candidate is a complex scalar boson. The model contains a new complex gauge singlet scalar boson and a new fermion whose gauge charge is the same as the right-handed down-type quark. We dub the new fermion the bottom partner. These new particles have Yukawa interactions with the SM down-type quarks. The DM candidate interacts with the SM particles through the Yukawa interactions. The Yukawa interactions are not only relevant to the annihilation process of the DM but also contribute to the flavor physics, such as the ΔF=2 processes. In addition, the flavor alignment of the Yukawa couplings is related to the decay modes of the bottom partner, and thus we can find the explicit correlations among the physical observables in DM physics, flavor physics, and the signals at the LHC. We survey the ΔF=2 processes based on the numerical analyses of the thermal relic density, the direct detection of the DM, and the current LHC bounds. We investigate the perturbative bound on the Yukawa coupling as well. A Study of a fermionic DM model with extra scalar quarks is also given for comparison.

  5. The Drosophila DmGluRA is required for social interaction and memory

    Directory of Open Access Journals (Sweden)

    Brian P. Schoenfeld

    2013-05-01

    Full Text Available Metabotropic glutamate receptors (mGluRs have well established roles in cognition andsocial behavior in mammals. Whether or not these roles have been conserved throughoutevolution from invertebrate species is less clear. Mammals have 8 mGluRs whereasDrosophila have a single DmGluRA, which has both Gi and Gq coupled signalingactivity. We have utilized Drosophila to examine the role of DmGluRA in social behaviorand various phases of memory. We have found that flies that are homozygous orheterozygous for loss of function mutations of DmGluRA have impaired social behaviorin male Drosophila. Futhermore, flies that are homozygous or heterozygous for loss offunction mutations of DmGluRA have impaired learning during training, immediate recallmemory, short-term memory and long-term memory as young adults. This workdemonstrates a role for metabotropic glutamate receptor activity in both social behaviorand memory in Drosophila.

  6. Characterizing dark matter interacting with extra charged leptons

    Science.gov (United States)

    Barducci, D.; Deandrea, A.; Moretti, S.; Panizzi, L.; Prager, H.

    2018-04-01

    In the context of a simplified leptophilic dark matter (DM) scenario where the mediator is a new charged fermion carrying leptonic quantum number and the DM candidate is either scalar or vector, the complementarity of different bounds is analyzed. In this framework, the extra lepton and DM are odd under a Z2 symmetry, and hence the leptonic mediator can only interact with the DM state and Standard Model leptons of various flavors. We show that there is the possibility to characterize the DM spin (scalar or vector), as well as the nature of the mediator, through a combined analysis of cosmological, flavor and collider data. We present an explicit numerical analysis for a set of benchmarks points of the viable parameter space of our scenario.

  7. Fermionic dark matter in a simple t-channel model

    International Nuclear Information System (INIS)

    Goyal, Ashok; Kumar, Mukesh

    2016-01-01

    We consider a fermionic dark matter (DM) particle in renormalizable Standard Model (SM) gauge interactions in a simple t-channel model. The DM particle interactions with SM fermions is through the exchange of scalar and vector mediators which carry colour or lepton number. In the case of coloured mediators considered in this study, we find that if the DM is thermally produced and accounts for the observed relic density almost the entire parameter space is ruled out by the direct detection observations. The bounds from the monojet plus missing energy searches at the Large Hadron Collider are less stringent in this case. In contrast for the case of Majorana DM, we obtain strong bounds from the monojet searches which rule out DM particles of mass less than about a few hundred GeV for both the scalar and vector mediators.

  8. Serum metabonomics of NAFLD plus T2DM based on liquid chromatography-mass spectrometry.

    Science.gov (United States)

    Chen, Yang; Li, Chunlong; Liu, Liyan; Guo, Fuchuan; Li, Songtao; Huang, Lina; Sun, Changhao; Feng, Rennan

    2016-09-01

    Nonalcoholic fatty liver disease (NAFLD), a main liver disease around the world, is closely associated with insulin resistance, type 2 diabetes mellitus (T2DM) and other metabolic diseases. The objective of this study is to identify distinct metabolites of NAFLD patients with or without T2DM. We used a biomarker-discovery population to find distinct metabolites of NAFLD patients with or without T2DM. Then, a validation population was applied to test the model of the biomarker-discovery population. All the individuals received anthropometric and common biochemical measurements. The metabolic data were analyzed by multivariable statistical analyses using ultra-high-performance liquid chromatography/quadrupole time-of-flight-tandem mass spectrometry. There were 7, 7, 2 metabolites in the positive electrospray ionization (ESI(+)) mode, which were identified between groups from both the biomarker-discovery and validation population. The NAFLD group showed higher concentrations of oleamide, l-phenylalanine, l-proline, bilirubin, l-palmitoylcarnitine, and PC (20:5) and a lower concentration of Lyso-PAF C-18 than those of control. Compared with the control group, the NAFLD+T2DM group displayed higher oleamide, l-leucine, LysoPC (14:0), bilirubin, tetradecenoylcarnitine, linoleyl carnitine, and tetradecadiencarnitine in serum. Tetradecenoylcarnitine and tetradecadiencarnitine were more elevated in patients with NAFLD+T2DM than in the NAFLD group. Serum metabonomic analyses displayed great metabolic changes in patients with NAFLD and NAFLD plus T2DM. Our study is beneficial in providing a further view into the pathogenesis and pathophysiology of NAFLD and NAFLD plus T2DM, which might be useful for the prevention and therapy of NAFLD and NAFLD plus T2DM. Copyright © 2016 The Canadian Society of Clinical Chemists. Published by Elsevier Inc. All rights reserved.

  9. Characterization of a Fasciola gigantica protein carrying two DM9 domains reveals cellular relocalization property.

    Science.gov (United States)

    Phadungsil, Wansika; Smooker, Peter M; Vichasri-Grams, Suksiri; Grams, Rudi

    2016-01-01

    Even at the present age of whole-organism analysis, e.g., genomics, transcriptomics, and proteomics, the biological roles of many proteins remain unresolved. Classified among the proteins of unknown function is a family of proteins harboring repeats of the DM9 domain, a 60-75 amino acids motif first described in a small number of Drosophila melanogaster proteins. Proteins may carry two or more DM9 domains either in combination with other domains or as their sole constituent. Here we have characterized a 16.8 kDa Fasciola gigantica protein comprising two tandem repeated DM9 domains (FgDM9-1). The protein was located in the parenchyma of the immature and mature parasite and consequently it was not detected in the ES product of the parasite but only in the whole worm extract. Interestingly, extraction with SDS yielded a substantially higher amount of the protein suggesting association with insoluble cell components. In Sf9 insect cells a heterologously expressed EGFP-FgDM9-1 chimera showed cell-wide distribution but relocated to vesicle-like structures in the cytoplasm after stimulating cellular stress by bacteria, heat shock or chloroquine. These structures did not colocalize with the markers of endocytosis/phagocytosis ubiquitin, RAB7, GABARAP. The same behavior was noted for Aedes aegypti PRS1, a homologous mosquito DM9 protein as a positive control while EGFP did not exhibit such relocation in the insect cells. Cross-linking experiments on soluble recombinant FgDM9-1 indicated that the protein can undergo specific oligomerization. It is speculated that proteins carrying the DM9 domain have a role in vesicular transport in flatworms and insects. Copyright © 2016 Elsevier B.V. All rights reserved.

  10. The clinical significance of serum Leptin in the pathogenesis of 2DM and obesity

    International Nuclear Information System (INIS)

    Liu Chunyu; Lu Kuan; Gao Yanyan

    2001-01-01

    Objective: To study the relationship between serum Leptin ad insulin, body fat distribution and testosterone in 2-DM patients. Methods: The fasting blood serum Leptin and insulin levels in 65 2DM patients and 42 controls were measured by radioimmunoassay. Abdominal subcutaneous adipose tissue volume (ASF) and abdominal visceral adipose tissue volume (AVF) were measured by spiral CT SSD soft-ware in 32 2DM patients. The authors also measured the Leptin before and 2h after a 75 g OGTT in 34 2DM patients and fasting plasma testosterone in 30 2DM males. Results: DM group and normal group had equal number of females and were matched in BMI. Baseline plasma Leptin concentrations were not significantly different between the groups (P 14 mmol/L) had lower Leptin levels (P < 0.05). Sex, BMI, ASF were important factors contributing to the serum Leptin. The Leptin concentrations were significantly positively correlated with BMI (r 0.57, P0.0001), ASF(r = 0.67 P0.025) and insulin (r = 0.47, P0.0013) and was negative correlated with the serum testosterone (r = -0.061, P0.025). Conclusion: There were no abnormal Leptin levels in 2DM implies, suggesting that Leptin might not be the main causing factor in 2DM. The poorly metabolic controlled patients might have lack of Leptin. The lower Leptin levels in men might be caused by testosterone, sex BMI, ASF were important factors contributing to the serum Leptin levels

  11. Hubungan Lama Menderita DM dengan Perilaku Perawatan Kaki secara Mandiri untuk Mencegah Ulkus Diabetikum

    OpenAIRE

    Apriliyasari, Renny Wulan

    2015-01-01

    Diabetes Mellitus (DM) atau yang biasa disebut kencing manis merupakan suatu kelompok penyakit metabolik dengan karakteristik gula darah melebihi nilai normal. Data dari Dinas Kesehatan Kabupaten Pati jumlah penderita DM meningkat, dengan rata-rata pada 2 tahun 2008-2009 sebanyak 1950 orang. Hasil survey di RSUD RAA Soewondo Pati, penyakit diabetes mellitus menempati peringkat pertama penyakit rawat jalan 2013 dengan 3893 total kunjungan atau sebesar 4,83%. Salah satu hal penting pada pasien ...

  12. Compatibility of a dark matter discovery at XENONnT or LZ with the WIMP thermal production mechanism

    Science.gov (United States)

    Catena, Riccardo; Conrad, Jan; Krauss, Martin B.

    2018-05-01

    The discovery of dark matter (DM) at XENONnT or LZ would place constraints on DM particle mass and coupling constants. It is interesting to ask when these constraints can be compatible with the DM thermal production mechanism. We address this question within the most general set of renormalizable models that preserve Lorentz and gauge symmetry, and that extend the standard model by one DM candidate of mass mDM and one particle of mass Mmed mediating DM-quark interactions. Our analysis divides into two parts. First, we postulate that XENONnT/LZ has detected μS˜O (100 ) signal events, and use this input to calculate the DM relic density, ΩDMh2. Then, we identify the regions in the Mmed-ΩDMh2 plane which are compatible with the observed signal and with current CMB data. We find that for most of the models considered here, O (100 ) signal events at XENONnT/LZ and the DM thermal production are only compatible for resonant DM annihilations, i.e. for Mmed≃2 mDM. In this case, XENONnT/LZ would be able to simultaneously measure mDM and Mmed. We also discuss the dependence of our results on mDM, μS and the DM spin, and provide analytic expressions for annihilation cross sections and mediator decay widths for all models considered in this study.

  13. Naturalness of MSSM dark matter

    Energy Technology Data Exchange (ETDEWEB)

    Cabrera, María Eugenia [Instituto de Física, Universidade de São Paulo,São Paulo SP 05508-900 (Brazil); Casas, J. Alberto [Instituto de Física Teórica, IFT-UAM/CSIC, Universidad Autónoma de Madrid,Cantoblanco, 28049 Madrid (Spain); Delgado, Antonio [Department of Physics, University of Notre Dame,Notre Dame, IN 46556 (United States); Robles, Sandra [Instituto de Física Teórica, IFT-UAM/CSIC, Universidad Autónoma de Madrid,Cantoblanco, 28049 Madrid (Spain); Departamento de Física Teórica, Universidad Autónoma de Madrid,Cantoblanco, 28049 Madrid (Spain); Austri, Roberto Ruiz de [Instituto de Física Corpuscular,IFIC-UV/CSIC, Valencia (Spain)

    2016-08-08

    There exists a vast literature examining the electroweak (EW) fine-tuning problem in supersymmetric scenarios, but little concerned with the dark matter (DM) one, which should be combined with the former. In this paper, we study this problem in an, as much as possible, exhaustive and rigorous way. We have considered the MSSM framework, assuming that the LSP is the lightest neutralino, χ{sub 1}{sup 0}, and exploring the various possibilities for the mass and composition of χ{sub 1}{sup 0}, as well as different mechanisms for annihilation of the DM particles in the early Universe (well-tempered neutralinos, funnels and co-annihilation scenarios). We also present a discussion about the statistical meaning of the fine-tuning and how it should be computed for the DM abundance, and combined with the EW fine-tuning. The results are very robust and model-independent and favour some scenarios (like the h-funnel when M{sub χ{sub 1{sup 0}}} is not too close to m{sub h}/2) with respect to others (such as the pure wino case). These features should be taken into account when one explores “natural SUSY” scenarios and their possible signatures at the LHC and in DM detection experiments.

  14. Millicharge or decay: a critical take on Minimal Dark Matter

    Energy Technology Data Exchange (ETDEWEB)

    Nobile, Eugenio Del [Department of Physics and Astronomy, UCLA, 475 Portola Plaza, Los Angeles, CA 90095 (United States); Dipartimento di Fisica e Astronomia “G. Galilei”, Università di Padova and INFN, Sezione di Padova,Via Marzolo 8, 35131 Padova (Italy); Nardecchia, Marco [DAMTP, University of Cambridge, Wilberforce Road, Cambridge CB3 0WA (United Kingdom); Panci, Paolo [Institut d’Astrophysique de Paris, UMR 7095 CNRS, Université Pierre et Marie Curie, 98 bis Boulevard Arago, Paris 75014 (France)

    2016-04-26

    Minimal Dark Matter (MDM) is a theoretical framework highly appreciated for its minimality and yet its predictivity. Of the two only viable candidates singled out in the original analysis, the scalar eptaplet has been found to decay too quickly to be around today, while the fermionic quintuplet is now being probed by indirect Dark Matter (DM) searches. It is therefore timely to critically review the MDM paradigm, possibly pointing out generalizations of this framework. We propose and explore two distinct directions. One is to abandon the assumption of DM electric neutrality in favor of absolutely stable, millicharged DM candidates which are part of SU(2){sub L} multiplets with integer isospin. Another possibility is to lower the cutoff of the model, which was originally fixed at the Planck scale, to allow for DM decays. We find new viable MDM candidates and study their phenomenology in detail.

  15. The DiskMass Survey : IV. The Dark-matter-dominated Galaxy UGC 463

    NARCIS (Netherlands)

    Westfall, Kyle B.; Bershady, Matthew A.; Verheijen, Marc A. W.; Andersen, David R.; Martinsson, Thomas P. K.; Swaters, Robert A.; Schechtman-Rook, Andrew

    2011-01-01

    We present a detailed and unique mass budget for the high surface brightness galaxy UGC 463, showing it is dominated by dark matter (DM) at radii beyond one scale length (h(R)) and has a baryonic-to-DM mass ratio of approximately 1:3 within 4.2h(R). Assuming a constant scale height (h(z); calculated

  16. The DiskMass Survey. IV. The Dark-matter-dominated Galaxy UGC 463

    NARCIS (Netherlands)

    Westfall, Kyle B.; Bershady, Matthew A.; Verheijen, Marc A. W.; Andersen, David R.; Martinsson, Thomas P. K.; Swaters, Robert A.; Schechtman-Rook, Andrew

    We present a detailed and unique mass budget for the high surface brightness galaxy UGC 463, showing it is dominated by dark matter (DM) at radii beyond one scale length (hR ) and has a baryonic-to-DM mass ratio of approximately 1:3 within 4.2hR . Assuming a constant scale height (hz ; calculated

  17. A two-component dark matter model with real singlet scalars ...

    Indian Academy of Sciences (India)

    2016-01-05

    Jan 5, 2016 ... We propose a two-component dark matter (DM) model, each component of which is a real singlet scalar, to explain results from both direct and indirect detection experiments. We put the constraints on the model parameters from theoretical bounds, PLANCK relic density results and direct DM experiments.

  18. Signatures of Earth-scattering in the direct detection of Dark Matter

    DEFF Research Database (Denmark)

    Kavanagh, Bradley J.; Catena, Riccardo; Kouvaris, Chris

    2017-01-01

    Direct detection experiments search for the interactions of Dark Matter (DM) particles with nuclei in terrestrial detectors. But if these interactions are sufficiently strong, DM particles may scatter in the Earth, affecting their distribution in the lab. We present a new analytic calculation...

  19. Little composite dark matter

    Science.gov (United States)

    Balkin, Reuven; Perez, Gilad; Weiler, Andreas

    2018-02-01

    We examine the dark matter phenomenology of a composite electroweak singlet state. This singlet belongs to the Goldstone sector of a well-motivated extension of the Littlest Higgs with T-parity. A viable parameter space, consistent with the observed dark matter relic abundance as well as with the various collider, electroweak precision and dark matter direct detection experimental constraints is found for this scenario. T-parity implies a rich LHC phenomenology, which forms an interesting interplay between conventional natural SUSY type of signals involving third generation quarks and missing energy, from stop-like particle production and decay, and composite Higgs type of signals involving third generation quarks associated with Higgs and electroweak gauge boson, from vector-like top-partners production and decay. The composite features of the dark matter phenomenology allows the composite singlet to produce the correct relic abundance while interacting weakly with the Higgs via the usual Higgs portal coupling λ _{ {DM}}˜ O(1%), thus evading direct detection.

  20. Little composite dark matter

    Energy Technology Data Exchange (ETDEWEB)

    Balkin, Reuven; Weiler, Andreas [Technische Universitaet Muenchen, First Physik-Department, Garching (Germany); Perez, Gilad [Weizmann Institute of Science, Department of Particle Physics and Astrophysics, Rehovot (Israel)

    2018-02-15

    We examine the dark matter phenomenology of a composite electroweak singlet state. This singlet belongs to the Goldstone sector of a well-motivated extension of the Littlest Higgs with T-parity. A viable parameter space, consistent with the observed dark matter relic abundance as well as with the various collider, electroweak precision and dark matter direct detection experimental constraints is found for this scenario. T-parity implies a rich LHC phenomenology, which forms an interesting interplay between conventional natural SUSY type of signals involving third generation quarks and missing energy, from stop-like particle production and decay, and composite Higgs type of signals involving third generation quarks associated with Higgs and electroweak gauge boson, from vector-like top-partners production and decay. The composite features of the dark matter phenomenology allows the composite singlet to produce the correct relic abundance while interacting weakly with the Higgs via the usual Higgs portal coupling λ{sub DM} ∝ O(1%), thus evading direct detection. (orig.)

  1. Dark matter "transporting" mechanism explaining positron excesses

    Science.gov (United States)

    Kim, Doojin; Park, Jong-Chul; Shin, Seodong

    2018-04-01

    We propose a novel mechanism to explain the positron excesses, which are observed by satellite-based telescopes including PAMELA and AMS-02, in dark matter (DM) scenarios. The novelty behind the proposal is that it makes direct use of DM around the Galactic Center where DM populates most densely, allowing us to avoid tensions from cosmological and astrophysical measurements. The key ingredients of this mechanism include DM annihilation into unstable states with a very long laboratory-frame life time and their "retarded" decay near the Earth to electron-positron pair(s) possibly with other (in)visible particles. We argue that this sort of explanation is not in conflict with relevant constraints from big bang nucleosynthesis and cosmic microwave background. Regarding the resultant positron spectrum, we provide a generalized source term in the associated diffusion equation, which can be readily applicable to any type of two-"stage" DM scenarios wherein production of Standard Model particles occurs at completely different places from those of DM annihilation. We then conduct a data analysis with the recent AMS-02 data to validate our proposal.

  2. Light mediators in dark matter direct detections

    International Nuclear Information System (INIS)

    Li, Tai; Miao, Sen; Zhou, Yu-Feng

    2015-01-01

    In an extended effective operator framework, we investigate in detail the effects of light mediators on the event spectra of dark matter (DM)-nucleus scatterings. The presence of light mediators changes the interpretation of the current experimental data, especially the determination of DM particle mass. We show by analytic and numerical illustrations that in general for all the operators relevant to spin-independent scatterings, the DM particle mass allowed by a given set of experimental data increases significantly when the mediator particle becomes lighter. For instance, in the case of CDMS-II-Si experiment, the allowed DM particle mass can reach ∼50 (100) GeV at 68% (90%) confidence level, which is much larger than ∼10 GeV in the case with contact interactions. The increase of DM particle mass saturates when the mediator mass is below O(10) MeV. The upper limits from other experiments such as SuperCDMS, CDMSlite, CDEX, XENON10/100, LUX, PandaX etc. all tend to be weaker toward high DM mass regions. In a combined analysis, we show that the presence of light mediators can partially relax the tension in the current results of CDMS-II-Si, SuperCDMS and LUX

  3. Searching for dark matter at colliders

    Energy Technology Data Exchange (ETDEWEB)

    Richard, Francois [IN2P3/CNRS et Universite Paris-Sud 11 Centre Scientifique d' Orsay, Laboratoire de l' Accelerateur Lineaire, Orsay (France); Arcadi, Giorgio; Mambrini, Yann [Universite Paris-Sud, Laboratoire de Physique Theorique, Orsay (France)

    2015-04-01

    Dark Matter (DM) detection prospects at future e{sup +}e{sup -} colliders are reviewed under the assumption that DM particles are fermions of the Majorana or Dirac type. Although the discussion is quite general, one will keep in mind the recently proposed candidate based on an excess of energetic photons observed in the center of our Galaxy with the Fermi-LAT satellite. In the first part we will assume that DM interactions are mediated by vector bosons, Z or Z'. In the case of Z-boson Direct Detection limits force only axial couplings with the DM. This solution can be naturally accommodated by Majorana DM but is disfavored by the GC excess. Viable scenarios can be instead found in the case of Z' mediator. These scenarios can be tested at e{sup +}e{sup -} colliders through ISR events, e{sup +}e{sup -} → XX + γ. A sensitive background reduction can be achieved by using highly polarized beams. In the second part scalar particles, in particular Higgs particles, have been considered as mediators. The case of the SM Higgs mediator is excluded by limits on the invisible branching ratio of the Higgs. On the contrary particularly interesting is the case in which the DM interactions are mediated by the pseudoscalar state A in two Higgs-doublet model scenarios. In this last case the main collider signature is e{sup +}e{sup -} → HA, H → hh, A → XX. (orig.)

  4. Searching for dark matter at colliders

    International Nuclear Information System (INIS)

    Richard, Francois; Arcadi, Giorgio; Mambrini, Yann

    2015-01-01

    Dark Matter (DM) detection prospects at future e + e - colliders are reviewed under the assumption that DM particles are fermions of the Majorana or Dirac type. Although the discussion is quite general, one will keep in mind the recently proposed candidate based on an excess of energetic photons observed in the center of our Galaxy with the Fermi-LAT satellite. In the first part we will assume that DM interactions are mediated by vector bosons, Z or Z'. In the case of Z-boson Direct Detection limits force only axial couplings with the DM. This solution can be naturally accommodated by Majorana DM but is disfavored by the GC excess. Viable scenarios can be instead found in the case of Z' mediator. These scenarios can be tested at e + e - colliders through ISR events, e + e - → XX + γ. A sensitive background reduction can be achieved by using highly polarized beams. In the second part scalar particles, in particular Higgs particles, have been considered as mediators. The case of the SM Higgs mediator is excluded by limits on the invisible branching ratio of the Higgs. On the contrary particularly interesting is the case in which the DM interactions are mediated by the pseudoscalar state A in two Higgs-doublet model scenarios. In this last case the main collider signature is e + e - → HA, H → hh, A → XX. (orig.)

  5. Decaying fermionic dark matter search with CALET

    Energy Technology Data Exchange (ETDEWEB)

    Bhattacharyya, S.; Torii, S. [Graduate School of Advanced Science and Engineering, Waseda University, 3-4-1, Okubo, Shinjuku, Tokyo, 169-8555 (Japan); Motz, H. [International Center for Science and Engineering Programs, Waseda University, 3-4-1, Okubo, Shinjuku, Tokyo, 169-8555 (Japan); Asaoka, Y., E-mail: saptashwab@ruri.waseda.jp, E-mail: motz@aoni.waseda.jp, E-mail: torii.shoji@waseda.jp, E-mail: yoichi.asaoka@aoni.waseda.jp [Research Institute for Science and Engineering, Waseda University, 3-4-1, Okubo, Shinjuku, Tokyo, 169-8555 (Japan)

    2017-08-01

    The ISS-based CALET (CALorimetric Electron Telescope) detector can play an important role in indirect search for Dark Matter (DM), measuring the electron+positron flux in the TeV region for the first time directly. With its fine energy resolution of approximately 2% and good proton rejection ratio (1:10{sup 5}) it has the potential to search for fine structures in the Cosmic Ray (CR) electron spectrum. In this context we discuss the ability of CALET to discern between signals originating from astrophysical sources and DM decay. We fit a parametrization of the local interstellar electron and positron spectra to current measurements, with either a pulsar or 3-body decay of fermionic DM as the extra source causing the positron excess. The expected CALET data for scenarios in which DM decay explains the excess are calculated and analyzed. The signal from this particular 3-body DM decay which can explain the recent measurements from the AMS−02 experiment is shown to be distinguishable from a single pulsar source causing the positron excess by 5 years of observation with CALET, based on the shape of the spectrum. We also study the constraints from diffuse γ-ray data on this DM-only explanation of the positron excess and show that especially for the possibly remaining parameter space a clearly identifiable signature in the CR electron spectrum exists.

  6. Comparative evaluation of average glandular dose and breast cancer detection between single-view digital breast tomosynthesis (DBT) plus single-view digital mammography (DM) and two-view DM: correlation with breast thickness and density

    Energy Technology Data Exchange (ETDEWEB)

    Shin, Sung Ui; Chang, Jung Min; Bae, Min Sun; Lee, Su Hyun; Cho, Nariya; Seo, Mirinae; Kim, Won Hwa; Moon, Woo Kyung [Seoul National University Hospital, Department of Radiology, Seoul (Korea, Republic of)

    2015-01-15

    To compare the average glandular dose (AGD) and diagnostic performance of mediolateral oblique (MLO) digital breast tomosynthesis (DBT) plus cranio-caudal (CC) digital mammography (DM) with two-view DM, and to evaluate the correlation of AGD with breast thickness and density. MLO and CC DM and DBT images of both breasts were obtained in 149 subjects. AGDs of DBT and DM per exposure were recorded, and their correlation with breast thickness and density were evaluated. Paired data of MLO DBT plus CC DM and two-view DM were reviewed for presence of malignancy in a jack-knife alternative free-response ROC (JAFROC) method. The AGDs of both DBT and DM, and differences in AGD between DBT and DM (ΔAGD), were correlated with breast thickness and density. The average JAFROC figure of merit (FOM) was significantly higher on the combined technique than two-view DM (P = 0.005). In dense breasts, the FOM and sensitivity of the combined technique was higher than that of two-view DM (P = 0.003) with small ΔAGD. MLO DBT plus CC DM provided higher diagnostic performance than two-view DM in dense breasts with a small increase in AGD. (orig.)

  7. Comparative evaluation of average glandular dose and breast cancer detection between single-view digital breast tomosynthesis (DBT) plus single-view digital mammography (DM) and two-view DM: correlation with breast thickness and density

    International Nuclear Information System (INIS)

    Shin, Sung Ui; Chang, Jung Min; Bae, Min Sun; Lee, Su Hyun; Cho, Nariya; Seo, Mirinae; Kim, Won Hwa; Moon, Woo Kyung

    2015-01-01

    To compare the average glandular dose (AGD) and diagnostic performance of mediolateral oblique (MLO) digital breast tomosynthesis (DBT) plus cranio-caudal (CC) digital mammography (DM) with two-view DM, and to evaluate the correlation of AGD with breast thickness and density. MLO and CC DM and DBT images of both breasts were obtained in 149 subjects. AGDs of DBT and DM per exposure were recorded, and their correlation with breast thickness and density were evaluated. Paired data of MLO DBT plus CC DM and two-view DM were reviewed for presence of malignancy in a jack-knife alternative free-response ROC (JAFROC) method. The AGDs of both DBT and DM, and differences in AGD between DBT and DM (ΔAGD), were correlated with breast thickness and density. The average JAFROC figure of merit (FOM) was significantly higher on the combined technique than two-view DM (P = 0.005). In dense breasts, the FOM and sensitivity of the combined technique was higher than that of two-view DM (P = 0.003) with small ΔAGD. MLO DBT plus CC DM provided higher diagnostic performance than two-view DM in dense breasts with a small increase in AGD. (orig.)

  8. The chemical composition and in vitro dry matter digestibility of ...

    African Journals Online (AJOL)

    The mean IVDMD of maize residues obtained by means of a whole plant maize harvester was found to be relatively high (IVDMD = 55.6±7.0%) while the crude protein (CP) (46±10 g/kg dry matter (DM)) and phosphorus (P) (1.2±0.5 g/kg DM) concentrations were below the maintenance requirement for dry gestating beef ...

  9. Self-interacting dark matter

    Science.gov (United States)

    Mavromatos, Nick E.; Argüelles, Carlos R.; Ruffini, Remo; Rueda, Jorge A.

    Self-interacting dark matter (SIDM) is a hypothetical form of dark matter (DM), characterized by relatively strong (compared to the weak interaction strength) self-interactions (SIs), which has been proposed to resolve a number of issues concerning tensions between simulations and observations at the galactic or smaller scales. We review here some recent developments discussed at the 14th Marcel Grossmann Meeting (MG14), paying particular attention to restrictions on the SIDM (total) cross-section from using novel observables in merging galactic structures, as well as the rôle of SIDM on the Milky Way halo and its central region. We report on some interesting particle-physics inspired SIDM models that were discussed at MG14, namely the glueball DM, and a right-handed neutrino DM (with mass of a few tens of keV, that may exist in minimal extensions of the standard model (SM)), interacting among themselves via vector bosons mediators in the dark sector. A detailed phenomenology of the latter model on galactic scales, as well as the potential role of the right handed neutrinos in alleviating some of the small-scale cosmology problems, namely the discrepancies between observations and numerical simulations within standard ΛCDM and ΛWDM cosmologies are reported.

  10. Collider study on the loop-induced dark matter mediation

    Energy Technology Data Exchange (ETDEWEB)

    Tsai, Yuhsin, E-mail: yhtsai@umd.edu [Maryland Center for Fundamental Physics, University of Maryland, College Park, MD 20742 (United States)

    2016-06-21

    Collider experiments are one of the most promising ways to constrain Dark Matter (DM) interactions. For DM couplings involving light mediators, especially for the loop-mediated interactions, a meaningful interpretation of the results requires to go beyond effective field theory. In this note we discuss the study of the magnetic dipole interacting DM, focusing on a model with anarchic dark flavor structure. By including the momentum-dependent form factors that mediate the coupling – given by the Dark Penguin – in collider processes, we study bounds from monophoton, diphoton, and non-pointing photon searches at the LHC. We also compare our results to constraints from the direct detection experiments.

  11. Prospects for indirect detection of frozen-in dark matter

    Science.gov (United States)

    Heikinheimo, Matti; Tenkanen, Tommi; Tuominen, Kimmo

    2018-03-01

    We study observational consequences arising from dark matter (DM) of nonthermal origin, produced by dark freeze-out from a hidden sector heat bath. We assume this heat bath was populated by feebly coupled mediator particles, produced via a Higgs portal interaction with the Standard Model (SM). The dark sector then attained internal equilibrium with a characteristic temperature different from the SM photon temperature. We find that even if the coupling between the DM and the SM sectors is very weak, the scenario allows for indirect observational signals. We show how the expected strength of these signals depends on the temperature of the hidden sector at DM freeze-out.

  12. Particle dark matter signal in DAMA/LIBRA

    International Nuclear Information System (INIS)

    Bernabei, R.; Belli, P.; Di Marco, A.; Montecchia, F.; Cappella, F.; D'Angelo, A.; Incicchitti, A.; Prosperi, D.; Cerulli, R.; Dai, C.J.; He, H.L.; Ma, X.H.; Sheng, X.D.; Wang, R.G.; Ye, Z.P.

    2012-01-01

    The DAMA/LIBRA experiment, running at LNGS, has a sensitive mass of about 250 kg highly radiopure NaI(Tl) and it is mainly devoted to the investigation of Dark Matter (DM) particles in the Galactic halo by exploiting the model independent DM annual modulation signature. The present DAMA/LIBRA experiment and the former DAMA/NaI one have released so far results corresponding to a total exposure of 1.17 ton×yr over 13 annual cycles. They provide a model independent evidence of the presence of DM particles in the galactic halo at 8.9σ C.L.

  13. Collider study on the loop-induced dark matter mediation

    International Nuclear Information System (INIS)

    Tsai, Yuhsin

    2016-01-01

    Collider experiments are one of the most promising ways to constrain Dark Matter (DM) interactions. For DM couplings involving light mediators, especially for the loop-mediated interactions, a meaningful interpretation of the results requires to go beyond effective field theory. In this note we discuss the study of the magnetic dipole interacting DM, focusing on a model with anarchic dark flavor structure. By including the momentum-dependent form factors that mediate the coupling – given by the Dark Penguin – in collider processes, we study bounds from monophoton, diphoton, and non-pointing photon searches at the LHC. We also compare our results to constraints from the direct detection experiments.

  14. Dark matter study of NGC 5055

    Science.gov (United States)

    Ibrahim, Ungku Ferwani Salwa Ungku; Hashim, Norsiah; Abidin, Zamri Zainal

    2013-05-01

    This paper is about rediscovering dark matter (DM) in galaxies before the year 1970. It is an Italy-Malaysia Astroproject (SISSA-Radio Cosmology Research group), introducing to the field of DM. Investigations about the rotation curve (RC) of NGC 5055 or the Sunflower Galaxy at that time showed that there was a distinct possibility that they had the knowledge and also the theory of gravitation to initiate the study of dark matter. NGC 5055 was chosen because of its good kinematical and photometric data. Information of the surface brightness of this spiral galaxy will determine the disk length scale, RD. Using this RD and by fitting the RC data of NGC 5055 with the velocity profile of the Freeman's disk, we look at the results to conclude whether there are signs of dark matter in the Sunflower Galaxy.

  15. Induction of dexamethasone (DM) of histidine decarboxylase (HDC) in mast cells

    International Nuclear Information System (INIS)

    Ichikawa, A.; Imanishi, N.; Nakayama, T.; Asano, M.; Tomita, K.

    1986-01-01

    Effects of glucocorticoids on HDC in cultured mouse mastocytoma P-815 cells and rat peritoneal mast cells (RPMC) were investigated to explore the role of steroids in inflammatory tissues. DM (1 nM to 10 μM) significantly elevated the histamine content and HDC activity of P-815 cells (37 0 C, 24 hrs), accompanying with a growth retardation of the cells by about 40%. In contrast to histamine, serotonin levels of P-815 cells were decreased by treatment with DM. However, DM had no significant effects on the activities of various enzymes other than HDC present in granules or membrane of P-815 cells. DM-induced increases of histamine and HDC activity were completely suppressed by the addition of cycloheximide and actinomycin D. P-815 cells were found to have the binding sites for 3 H-DM in the cytosol (Kd=2.2 nM, 450 sites/cell) and in the nuclei (Kd=0.1 nM, 39 sites/nucleus). Purified HDC from P-815 cells was identified to be an isozyme of mast cell type enzyme (MW=110K, pI=5.4). In contrast, the basal histamine level of cultured RPMC was not affected by treatment of DM, which suppressed histamine release activity induced by DNP-ascaris antiserum by 40%-50%. Histamine-depleted RPMC after degranulation partially recovered histamine level by 50%-60% in the presence of DM. These results showed that glucocorticoids specifically stimulated histamine formation with the increased de novo synthesis of HDC in mast cells

  16. Brain gray matter structural network in myotonic dystrophy type 1.

    Directory of Open Access Journals (Sweden)

    Atsuhiko Sugiyama

    Full Text Available This study aimed to investigate abnormalities in structural covariance network constructed from gray matter volume in myotonic dystrophy type 1 (DM1 patients by using graph theoretical analysis for further clarification of the underlying mechanisms of central nervous system involvement. Twenty-eight DM1 patients (4 childhood onset, 10 juvenile onset, 14 adult onset, excluding three cases from 31 consecutive patients who underwent magnetic resonance imaging in a certain period, and 28 age- and sex- matched healthy control subjects were included in this study. The normalized gray matter images of both groups were subjected to voxel based morphometry (VBM and Graph Analysis Toolbox for graph theoretical analysis. VBM revealed extensive gray matter atrophy in DM1 patients, including cortical and subcortical structures. On graph theoretical analysis, there were no significant differences between DM1 and control groups in terms of the global measures of connectivity. Betweenness centrality was increased in several regions including the left fusiform gyrus, whereas it was decreased in the right striatum. The absence of significant differences between the groups in global network measurements on graph theoretical analysis is consistent with the fact that the general cognitive function is preserved in DM1 patients. In DM1 patients, increased connectivity in the left fusiform gyrus and decreased connectivity in the right striatum might be associated with impairment in face perception and theory of mind, and schizotypal-paranoid personality traits, respectively.

  17. Searches for Dark Matter with the ATLAS detector

    CERN Document Server

    Fischer, Cora; The ATLAS collaboration

    2017-01-01

    Dark matter searches carried out with the ATLAS experiment with Run 2 data are summarised and presented. Interpretations focus on simplified models where the dark matter particles are produced via the exchange of a heavy new mediator. The results of different analyses are combined as an exclusion in the plane m_DM vs M_med. Exclusion limits are also compared with direct dark matter search experiments.

  18. A lower bound on the mass of dark matter particles

    International Nuclear Information System (INIS)

    Boyarsky, Alexey; Ruchayskiy, Oleg; Iakubovskyi, Dmytro

    2009-01-01

    We discuss the bounds on the mass of Dark Matter (DM) particles, coming from the analysis of DM phase-space distribution in dwarf spheroidal galaxies (dSphs). After reviewing the existing approaches, we choose two methods to derive such a bound. The first one depends on the information about the current phase space distribution of DM particles only, while the second one uses both the initial and final distributions. We discuss the recent data on dSphs as well as astronomical uncertainties in relevant parameters. As an application, we present lower bounds on the mass of DM particles, coming from various dSphs, using both methods. The model-independent bound holds for any type of fermionic DM. Stronger, model-dependent bounds are quoted for several DM models (thermal relics, non-resonantly and resonantly produced sterile neutrinos, etc.). The latter bounds rely on the assumption that baryonic feedback cannot significantly increase the maximum of a distribution function of DM particles. For the scenario in which all the DM is made of sterile neutrinos produced via non-resonant mixing with the active neutrinos (NRP) this gives m NRP > 1.7 keV. Combining these results in their most conservative form with the X-ray bounds of DM decay lines, we conclude that the NRP scenario remains allowed in a very narrow parameter window only. This conclusion is independent of the results of the Lyman-α analysis. The DM model in which sterile neutrinos are resonantly produced in the presence of lepton asymmetry remains viable. Within the minimal neutrino extension of the Standard Model (the νMSM), both mass and the mixing angle of the DM sterile neutrino are bounded from above and below, which suggests the possibility for its experimental search

  19. Dark matter and exotic neutrino interactions in direct detection searches

    Energy Technology Data Exchange (ETDEWEB)

    Bertuzzo, Enrico [Departamento de Física Matemática, Instituto de Física, Universidade de São Paulo,R. do Matão 1371, CEP. 05508-090, São Paulo (Brazil); Deppisch, Frank F. [Department of Physics and Astronomy, University College London,London WC1E 6BT (United Kingdom); Kulkarni, Suchita [Institut für Hochenergiephysik, Österreichische Akademie der Wissenschaften,Nikolsdorfer Gasse 18, 1050 Wien (Austria); Gonzalez, Yuber F. Perez; Funchal, Renata Zukanovich [Departamento de Física Matemática, Instituto de Física, Universidade de São Paulo,R. do Matão 1371, CEP. 05508-090, São Paulo (Brazil)

    2017-04-12

    We investigate the effect of new physics interacting with both Dark Matter (DM) and neutrinos at DM direct detection experiments. Working within a simplified model formalism, we consider vector and scalar mediators to determine the scattering of DM as well as the modified scattering of solar neutrinos off nuclei. Using existing data from LUX as well as the expected sensitivity of LUX-ZEPLIN and DARWIN, we set limits on the couplings of the mediators to quarks, neutrinos and DM. Given the current limits, we also assess the true DM discovery potential of direct detection experiments under the presence of exotic neutrino interactions. In the case of a vector mediator, we show that the DM discovery reach of future experiments is affected for DM masses m{sub χ}≲10 GeV or DM scattering cross sections σ{sub χ}≲10{sup −47} cm{sup 2}. On the other hand, a scalar mediator will not affect the discovery reach appreciably.

  20. Searches for Dark Matter in ATLAS

    CERN Document Server

    Alpigiani, Cristiano; The ATLAS collaboration

    2017-01-01

    Although the existence of Dark Matter (DM) is well established by many astronomical measurements, its nature still remains one of the unsolved puzzles of particles physics. The unprecedented energy reached by the Large Hadron Collider (LHC) at CERN has allowed exploration of previously unaccessible kinematic regimes in the search for new phenomena. An overview of most recent searches for dark matter with the ATLAS detector at LHC is presented and the interpretation of the results in terms of effective field theory and simplified models is discussed. The exclusion limits set by the ATLAS searches are compared to the constraints from direct dark matter detection experiments.

  1. Novel dark matter phenomenology at colliders

    Science.gov (United States)

    Wardlow, Kyle Patrick

    While a suitable candidate particle for dark matter (DM) has yet to be discovered, it is possible one will be found by experiments currently investigating physics on the weak scale. If discovered on that energy scale, the dark matter will likely be producible in significant quantities at colliders like the LHC, allowing the properties of and underlying physical model characterizing the dark matter to be precisely determined. I assume that the dark matter will be produced as one of the decay products of a new massive resonance related to physics beyond the Standard Model, and using the energy distributions of the associated visible decay products, develop techniques for determining the symmetry protecting these potential dark matter candidates from decaying into lighter Standard Model (SM) particles and to simultaneously measure the masses of both the dark matter candidate and the particle from which it decays.

  2. Dark Matter

    Directory of Open Access Journals (Sweden)

    Einasto J.

    2011-06-01

    Full Text Available I give a review of the development of the concept of dark matter. The dark matter story passed through several stages from a minor observational puzzle to a major challenge for theory of elementary particles. Modern data suggest that dark matter is the dominant matter component in the Universe, and that it consists of some unknown non-baryonic particles. Dark matter is the dominant matter component in the Universe, thus properties of dark matter particles determine the structure of the cosmic web.

  3. Asymmetric dark matter: residual annihilations and self-interactions arXiv

    CERN Document Server

    Baldes, Iason; Panci, Paolo; Petraki, Kalliopi; Sala, Filippo; Taoso, Marco

    Dark matter (DM) coupled to light mediators has been invoked to resolve the putative discrepancies between collisionless cold DM and galactic structure observations. However, $\\gamma$-ray searches and the CMB strongly constrain such scenarios. To ease the tension, we consider asymmetric DM. We show that, contrary to the common lore, detectable annihilations occur even for large asymmetries, and derive bounds from the CMB, $\\gamma$-ray, neutrino and antiproton searches. We then identify the viable space for self-interacting DM. Direct detection does not exclude this scenario, but provides a way to test it.

  4. Quantitative Proteomic Analysis of Hepatic Tissue of T2DM Rhesus Macaque

    Directory of Open Access Journals (Sweden)

    Tingfu Du

    2017-01-01

    Full Text Available Type 2 diabetes mellitus (T2DM is a metabolic disorder that severely affects human health, but the pathogenesis of the disease remains unknown. The high-fat/high-sucrose diets combined with streptozotocin- (STZ- induced nonhuman primate animal model of diabetes are a valuable research source of T2DM. Here, we present a study of a STZ rhesus macaque model of T2DM that utilizes quantitative iTRAQ-based proteomic method. We compared the protein profiles in the liver of STZ-treated macaques as well as age-matched healthy controls. We identified 171 proteins differentially expressed in the STZ-treated groups, about 70 of which were documented as diabetes-related gene in previous studies. Pathway analyses indicated that the biological functions of differentially expressed proteins were related to glycolysis/gluconeogenesis, fatty acid metabolism, complements, and coagulation cascades. Expression change in tryptophan metabolism pathway was also found in this study which may be associations with diabetes. This study is the first to explore genome-wide protein expression in hepatic tissue of diabetes macaque model using HPLC-Q-TOF/MS technology. In addition to providing potential T2DM biomarkers, this quantitative proteomic study may also shed insights regarding the molecular pathogenesis of T2DM.

  5. Replacing single-view mediolateral oblique (MLO) digital mammography (DM) with synthesized mammography (SM) with digital breast tomosynthesis (DBT) images: Comparison of the diagnostic performance and radiation dose with two-view DM with or without MLO-DBT

    Energy Technology Data Exchange (ETDEWEB)

    Kang, Hyo-Jin [Department of Radiology, Seoul National University Hospital, 03080 (Korea, Republic of); Chang, Jung Min, E-mail: imchangjm@gmail.com [Department of Radiology, Seoul National University Hospital, 03080 (Korea, Republic of); Department of Radiology, Seoul National University College of Medicine, 03080 (Korea, Republic of); Lee, Joongyub [Medical Research Collaborating Center, Biomedical Research Institution, Seoul National University Hospital, 03080 (Korea, Republic of); Song, Sung Eun; Shin, Sung Ui [Department of Radiology, Seoul National University Hospital, 03080 (Korea, Republic of); Kim, Won Hwa [Department of Radiology, Kyungpook National University Hospital, 41944 (Korea, Republic of); Bae, Min Sun [Department of Radiology, Seoul National University Hospital, 03080 (Korea, Republic of); Moon, Woo Kyung [Department of Radiology, Seoul National University Hospital, 03080 (Korea, Republic of); Department of Radiology, Seoul National University College of Medicine, 03080 (Korea, Republic of); Institute of Radiation Medicine, Seoul National University College Medical Research Center, 03080 (Korea, Republic of)

    2016-11-15

    Objectives: To evaluate the diagnostic performance and radiation dose of single view cranio-caudal (CC) digital mammography (DM) plus mediolateral oblique (MLO) digital breast tomosynthesis (DBT) combined with synthesized mammography (SM) in comparison with two-view DM with or without DBT. Material and methods: This study was approved by our institutional review board, and informed consent was obtained from 130 women. Paired two-view DM and single MLO-DBT with SM images were acquired, and four independent retrospective reading sessions of different combinations of DM, SM and DBT were performed for the presence of malignant tumors using jackknife alternative free-response receiver operator curve (JAFROC) methods. The diagnostic performances and average glandular dose (AGD) were compared between different combinations of DM, SM and DBT. Results: Of 159 lesions in 130 patients, 27 were malignant. When using MLO-DBT with SM instead of MLO-DM, a significantly higher sensitivity (P = 0.016) and specificity (P = 0.012) were noted than with two-view DM, and comparable figure of merit (FOM), sensitivity, and specificity to two-view DM with DBT were noted. The mean AGD of CC-DM plus MLO-DBT with SM was 5.78mGy ± 1.06 per patient, which was significantly lower than that with two-view DM with MLO-DBT (8.45mGy ± 1.32; P <0.001) and slightly higher than that with two-view DM (5.30mGy ± 0.63). Conclusions: The combined use of CC-DM plus MLO-DBT with SM showed higher sensitivity and specificity to two-view DM with a smaller AGD increment and comparable diagnostic performance to that of two-view DM with MLO-DBT with a significantly lower mean AGD.

  6. SGLT-2 Inhibitors: Are They a Promising Treatment Option in T2DM Patients with NAFLD?

    Directory of Open Access Journals (Sweden)

    Dimitrios Patoulias

    2018-04-01

    Full Text Available Sodium glucose co-transporter type 2 inhibitors (SGLT-2 inhibitors are a class of antidiabetics, recently approved for the treatment of patients with T2DM. They feature cardioprotective and renoprotective action, while they exert beneficial effects on metabolic parameters. Non-alcoholic fatty liver disease (NAFLD is a frequent co-morbidity in diabetic patients. Its prevalence reaches up to 70%. Since there is no specific treatment approved for NAFLD, both experimental and clinical studies have been recently conducted highlighting the efficacy and safety of SGLT-2 inhibitors mainly in animal models and secondarily in patients with T2DM and NAFLD. This class of antidiabetics seems very attractive, improving both glycemic control and liver function tests, while inhibiting NAFLD progression. However, further investigation is required to establish them as a first-line treatment option in T2DM patients with NAFLD, after thorough assessment of their efficacy and safety in clinical practice.

  7. Plant insecticide L-canavanine repels Drosophila via the insect orphan GPCR DmX.

    Directory of Open Access Journals (Sweden)

    Christian Mitri

    2009-06-01

    Full Text Available For all animals, the taste sense is crucial to detect and avoid ingesting toxic molecules. Many toxins are synthesized by plants as a defense mechanism against insect predation. One example of such a natural toxic molecule is L-canavanine, a nonprotein amino acid found in the seeds of many legumes. Whether and how insects are informed that some plants contain L-canavanine remains to be elucidated. In insects, the taste sense relies on gustatory receptors forming the gustatory receptor (Gr family. Gr proteins display highly divergent sequences, suggesting that they could cover the entire range of tastants. However, one cannot exclude the possibility of evolutionarily independent taste receptors. Here, we show that L-canavanine is not only toxic, but is also a repellent for Drosophila. Using a pharmacogenetic approach, we find that flies sense food containing this poison by the DmX receptor. DmXR is an insect orphan G-protein-coupled receptor that has partially diverged in its ligand binding pocket from the metabotropic glutamate receptor family. Blockade of DmXR function with an antagonist lowers the repulsive effect of L-canavanine. In addition, disruption of the DmXR encoding gene, called mangetout (mtt, suppresses the L-canavanine repellent effect. To avoid the ingestion of L-canavanine, DmXR expression is required in bitter-sensitive gustatory receptor neurons, where it triggers the premature retraction of the proboscis, thus leading to the end of food searching. These findings show that the DmX receptor, which does not belong to the Gr family, fulfills a gustatory function necessary to avoid eating a natural toxin.

  8. The combined effect of the T2DM susceptibility genes is an important risk factor for T2DM in non-obese Japanese: a population based case-control study

    Directory of Open Access Journals (Sweden)

    Yamakawa-Kobayashi Kimiko

    2012-02-01

    Full Text Available Abstract Background Type 2 diabetes mellitus (T2DM is a complex endocrine and metabolic disorder. Recently, several genome-wide association studies (GWAS have identified many novel susceptibility loci for T2DM, and indicated that there are common genetic causes contributing to the susceptibility to T2DM in multiple populations worldwide. In addition, clinical and epidemiological studies have indicated that obesity is a major risk factor for T2DM. However, the prevalence of obesity varies among the various ethnic groups. We aimed to determine the combined effects of these susceptibility loci and obesity/overweight for development of T2DM in the Japanese. Methods Single nucleotide polymorphisms (SNPs in or near 17 susceptibility loci for T2DM, identified through GWAS in Caucasian and Asian populations, were genotyped in 333 cases with T2DM and 417 control subjects. Results We confirmed that the cumulative number of risk alleles based on 17 susceptibility loci for T2DM was an important risk factor in the development of T2DM in Japanese population (P P P = 0.88 for trend. Conclusions Our findings indicate that there is an etiological heterogeneity of T2DM between obese/overweight and non-obese subjects.

  9. Hidden U (1 ) gauge symmetry realizing a neutrinophilic two-Higgs-doublet model with dark matter

    Science.gov (United States)

    Nomura, Takaaki; Okada, Hiroshi

    2018-04-01

    We propose a neutrinophilic two-Higgs-doublet model with hidden local U (1 ) symmetry, where active neutrinos are Dirac type, and a fermionic dark matter (DM) candidate is naturally induced as a result of remnant symmetry even after the spontaneous symmetry breaking. In addition, a physical Goldstone boson arises as a consequence of two types of gauge singlet bosons and contributes to the DM phenomenologies as well as an additional neutral gauge boson. Then, we analyze the relic density of DM within the safe range of direct detection searches and show the allowed region of dark matter mass.

  10. Signatures of Earth-scattering in the direct detection of Dark Matter

    DEFF Research Database (Denmark)

    Kavanagh, Bradley J.; Catena, Riccardo; Kouvaris, Chris

    2017-01-01

    Direct detection experiments search for the interactions of Dark Matter (DM) particles with nuclei in terrestrial detectors. But if these interactions are sufficiently strong, DM particles may scatter in the Earth, affecting their distribution in the lab. We present a new analytic calculation...... of this 'Earth-scattering' effect in the regime where DM particles scatter at most once before reaching the detector. We perform the calculation self-consistently, taking into account not only those particles which are scattered away from the detector, but also those particles which are deflected towards...... the detector. Taking into account a realistic model of the Earth and allowing for a range of DM-nucleon interactions, we present the EarthShadow code, which we make publicly available, for calculating the DM velocity distribution after Earth-scattering. Focusing on low-mass DM, we find that Earth...

  11. Solar Extreme UV radiation and quark nugget dark matter model

    Science.gov (United States)

    Zhitnitsky, Ariel

    2017-10-01

    We advocate the idea that the surprising emission of extreme ultra violet (EUV) radiation and soft x-rays from the Sun are powered externally by incident dark matter (DM) particles. The energy and the spectral shape of this otherwise unexpected solar irradiation is estimated within the quark nugget dark matter model. This model was originally invented as a natural explanation of the observed ratio Ωdark ~ Ωvisible when the DM and visible matter densities assume the same order of magnitude values. This generic consequence of the model is a result of the common origin of both types of matter which are formed during the same QCD transition and both proportional to the same fundamental dimensional parameter ΛQCD. We also present arguments suggesting that the transient brightening-like "nanoflares" in the Sun may be related to the annihilation events which inevitably occur in the solar atmosphere within this dark matter scenario.

  12. Solid Matter

    CERN Document Server

    Angelo, Joseph A

    2011-01-01

    Supported by a generous quantity of full-color illustrations and interesting sidebars, Solid Matter introduces the basic characteristics and properties of solid matter. It briefly describes the cosmic connection of the elements, leading readers through several key events in human pre-history that resulted in more advanced uses of matter in the solid state. Chapters include:. -Solid Matter: An Initial Perspective. -Physical Behavior of Matter. -The Gravity of Matter. -Fundamentals of Materials Science. -Rocks and Minerals. -Metals. -Building Materials. -Carbon Earth's Most Versatile Element. -S

  13. Sourcing dark matter and dark energy from α-attractors

    International Nuclear Information System (INIS)

    Mishra, Swagat S.; Sahni, Varun; Shtanov, Yuri

    2017-01-01

    In [1], Kallosh and Linde drew attention to a new family of superconformal inflationary potentials, subsequently called α-attractors [2]. The α-attractor family can interpolate between a large class of inflationary models. It also has an important theoretical underpinning within the framework of supergravity. We demonstrate that the α-attractors have an even wider appeal since they may describe dark matter and perhaps even dark energy. The dark matter associated with the α-attractors, which we call α-dark matterDM), shares many of the attractive features of fuzzy dark matter, with V (φ) = ½ m 2 φ 2 , while having none of its drawbacks. Like fuzzy dark matter, αDM can have a large Jeans length which could resolve the cusp-core and substructure problems faced by standard cold dark matter. αDM also has an appealing tracker property which enables it to converge to the late-time dark matter asymptote, ( w ) ≅ 0, from a wide range of initial conditions. It thus avoids the enormous fine-tuning problems faced by the m 2 φ 2 potential in describing dark matter.

  14. Sourcing dark matter and dark energy from α-attractors

    Energy Technology Data Exchange (ETDEWEB)

    Mishra, Swagat S.; Sahni, Varun [Inter-University Centre for Astronomy and Astrophysics, Post Bag 4, Ganeshkhind, Pune 411 007 (India); Shtanov, Yuri, E-mail: swagat@iucaa.in, E-mail: varun@iucaa.in, E-mail: shtanov@bitp.kiev.ua [Bogolyubov Institute for Theoretical Physics, Kiev 03680 (Ukraine)

    2017-06-01

    In [1], Kallosh and Linde drew attention to a new family of superconformal inflationary potentials, subsequently called α-attractors [2]. The α-attractor family can interpolate between a large class of inflationary models. It also has an important theoretical underpinning within the framework of supergravity. We demonstrate that the α-attractors have an even wider appeal since they may describe dark matter and perhaps even dark energy. The dark matter associated with the α-attractors, which we call α-dark matterDM), shares many of the attractive features of fuzzy dark matter, with V (φ) = ½ m {sup 2}φ{sup 2}, while having none of its drawbacks. Like fuzzy dark matter, αDM can have a large Jeans length which could resolve the cusp-core and substructure problems faced by standard cold dark matter. αDM also has an appealing tracker property which enables it to converge to the late-time dark matter asymptote, ( w ) ≅ 0, from a wide range of initial conditions. It thus avoids the enormous fine-tuning problems faced by the m {sup 2}φ{sup 2} potential in describing dark matter.

  15. Constraints on Dark Matter Interactions with Standard Model Particles from Cosmic Microwave Background Spectral Distortions.

    Science.gov (United States)

    Ali-Haïmoud, Yacine; Chluba, Jens; Kamionkowski, Marc

    2015-08-14

    We propose a new method to constrain elastic scattering between dark matter (DM) and standard model particles in the early Universe. Direct or indirect thermal coupling of nonrelativistic DM with photons leads to a heat sink for the latter. This results in spectral distortions of the cosmic microwave background (CMB), the amplitude of which can be as large as a few times the DM-to-photon-number ratio. We compute CMB spectral distortions due to DM-proton, DM-electron, and DM-photon scattering for generic energy-dependent cross sections and DM mass m_{χ}≳1 keV. Using Far-Infrared Absolute Spectrophotometer measurements, we set constraints on the cross sections for m_{χ}≲0.1 MeV. In particular, for energy-independent scattering we obtain σ_{DM-proton}≲10^{-24} cm^{2} (keV/m_{χ})^{1/2}, σ_{DM-electron}≲10^{-27} cm^{2} (keV/m_{χ})^{1/2}, and σ_{DM-photon}≲10^{-39} cm^{2} (m_{χ}/keV). An experiment with the characteristics of the Primordial Inflation Explorer would extend the regime of sensitivity up to masses m_{χ}~1 GeV.

  16. Antiprotons from dark matter annihilation in the Galaxy. Astrophysical uncertainties

    Energy Technology Data Exchange (ETDEWEB)

    Evoli, Carmelo [Chinese Academy of Sciences, Beijing (China). National Astronomical Observatories; Cholis, Ilias; Ullio, Piero [SISSA, Sezione di Trieste (Italy); INFN, Sezione di Trieste (Italy); Grasso, Dario [INFN, Sezione di Pisa (Italy); Maccione, Luca [Deutsches Elektronen-Synchrotron (DESY), Hamburg (Germany)

    2011-08-15

    The latest years have seen steady progresses in WIMP dark matter (DM) searches, with hints of possible signals suggested by both direct and indirect detection experiments. Antiprotons can play a key role validating those interpretations since they are copiously produced by WIMP annihilations in the Galactic halo, and the secondary antiproton background produced by Cosmic Ray (CR) interactions is predicted with fair accuracy and matches the observed spectrum very well. Using the publicly available numerical DRAGON code, we reconsider antiprotons as a tool to constrain DM models discussing its power and limitations. We provide updated constraints on a wide class of annihilating DM models by comparing our predictions against the most up-to-date anti p measurements, taking also into account the latest spectral information on the p, He and other CR nuclei fluxes. Doing that, we probe carefully the uncertainties associated to both secondary and DM originated antiprotons, by using a variety of distinctively different assumptions for the propagation of CRs and for the DM distribution in the Galaxy. We find that the impact of the astrophysical uncertainties on constraining the DM properties can be much stronger, up to a factor of {proportional_to}50, than the one due to uncertainties on the DM distribution ({proportional_to}2-6). Remarkably, even reducing the uncertainties on the propagation parameters derived by local observables, non-local effects can still change DM model constraints even by 50%. Nevertheless, current anti p data place tight constraints on DM models, excluding some of those suggested in connection with indirect and direct searches. Finally we discuss the power of upcoming CR spectral data from the AMS-02 observatory to drastically reduce the uncertainties discussed in this paper and estimate the expected sensitivity of this instrument to some sets of DM models. (orig.)

  17. Probing the nature of Dark Matter with the SKA

    Science.gov (United States)

    Colafrancesco, S.; Regis, M.; Marchegiani, P.; Beck, G.; Beck, R.; Zechlin, H.; Lobanov, A.; Horns, D.

    2015-04-01

    Dark Matter (DM) is a fundamental ingredient of our Universe and of structure formation, and yet its nature is elusive to astrophysical probes. Information on the nature and physical properties of the WIMP (neutralino) DM (the leading candidate for a cosmologically relevant DM) can be obtained by studying the astrophysical signals of their annihilation/decay. Among the various e.m. signals, secondary electrons produced by neutralino annihilation generate synchrotron emission in the magnetized atmosphere of galaxy clusters and galaxies which could be observed as a diffuse radio emission (halo or haze) centered on the DM halo. A deep search for DM radio emission with SKA in local dwarf galaxies, galaxy regions with low star formation and galaxy clusters (with offset DM-baryonic distribution, like e.g. the Bullet cluster) can be very effective in constraining the neutralino mass, composition and annihilation cross-section. For the case of a dwarf galaxy, like e.g. Draco, the constraints on the DM annihilation cross-section obtainable with SKA1-MID will be at least a factor $\\sim 10^3$ more stringent than the limits obtained by Fermi-LAT in the $\\gamma$-rays. These limits scale with the value of the B field, and the SKA will have the capability to determine simultaneously both the magnetic field in the DM-dominated structures and the DM particle properties. The optimal frequency band for detecting the DM-induced radio emission is around $\\sim 1$ GHz, with the SKA1-MID Band 1 and 4 important to probe the synchrotron spectral curvature at low-$\

  18. Collider, direct and indirect detection of supersymmetric dark matter

    International Nuclear Information System (INIS)

    Baer, Howard; Park, Eun-Kyung; Tata, Xerxes

    2009-01-01

    We present an overview of supersymmetry (SUSY) searches, both at collider experiments and via searches for dark matter (DM). We focus on three DM possibilities in the SUSY context: the thermally produced neutralino, a mixture of axion and axino, and the gravitino, and compare and contrast signals that may be expected at colliders, in direct detection (DD) experiments searching of DM relics left over from the Big Bang, and indirect detection (ID) experiments designed to detect the products of DM annihilations within the solar interior or galactic halo. Detection of DM particles using multiple strategies provides complementary information that may shed light on the new physics associated with the DM sector. In contrast to the minimal supergravity (mSUGRA) model where the measured cold DM relic density restricts us to special regions mostly on the edge of the m 0 -m 1/2 plane, the entire parameter plane becomes allowed if the universality assumption is relaxed in models with just one additional parameter. Then, thermally produced neutralinos with a well-tempered mix of wino, bino and higgsino components, or with a mass adjusted so that their annihilation in the early Universe is Higgs-resonance-enhanced, can be the DM. Well-tempered neutralinos typically yield heightened rates for DD and ID experiments compared with generic predictions from mSUGRA. If instead DM consists of axinos (possibly together with axions) or gravitinos, then there exists the possibility of detection of quasi-stable next-to-lightest SUSY particles at colliding beam experiments, with especially striking consequences if the next-lightest-supersymmetric-particle (NLSP) is charged, but no DD or ID detection. The exception for mixed axion/axino DM is that DD of axions may be possible.

  19. Speech Matters

    DEFF Research Database (Denmark)

    Hasse Jørgensen, Stina

    2011-01-01

    About Speech Matters - Katarina Gregos, the Greek curator's exhibition at the Danish Pavillion, the Venice Biannual 2011.......About Speech Matters - Katarina Gregos, the Greek curator's exhibition at the Danish Pavillion, the Venice Biannual 2011....

  20. Memory Matters

    Science.gov (United States)

    ... Staying Safe Videos for Educators Search English Español Memory Matters KidsHealth / For Kids / Memory Matters What's in ... of your complex and multitalented brain. What Is Memory? When an event happens, when you learn something, ...

  1. On the singular set of harmonic maps into DM-complexes

    CERN Document Server

    Daskalopoulos, Georgios

    2016-01-01

    The authors prove that the singular set of a harmonic map from a smooth Riemammian domain to a Riemannian DM-complex is of Hausdorff codimension at least two. They also explore monotonicity formulas and an order gap theorem for approximately harmonic maps. These regularity results have applications to rigidity problems examined in subsequent articles.

  2. DISCOVERY OF LOW DM FAST RADIO TRANSIENTS: GEMINGA PULSAR CAUGHT IN THE ACT

    International Nuclear Information System (INIS)

    Maan, Yogesh

    2015-01-01

    We report the discovery of several energetic radio bursts at 34 MHz, using the Gauribidanur radio telescope. The radio bursts exhibit two important properties associated with the propagation of astronomical signals through the interstellar medium: (i) frequency dependent dispersive delays across the observing bandwidth and (ii) Faraday rotation of the plane of linear polarization. These bursts sample a range of dispersion measures (DM; 1.4–3.6 pc cm −3 ) and show DM-variation at timescales of the order of a minute. Using groups of bursts having a consistent DM, we show that the bursts have originated from the radio-quiet gamma-ray pulsar Geminga. Detection of these bursts supports the existence of occasional radio emission from Geminga. The rare occurrence of these bursts, and the short timescale variation in their DM (if really caused by the intervening medium or the pulsar magnetosphere), might provide clues as to why the pulsar has not been detected in earlier sensitive searches. We present details of the observations and search procedure used to discover these bursts, a detailed analysis of their properties, and evidences of these bursts being associated with Geminga pulsar, and briefly discuss the possible emission mechanism of these bursts

  3. MIMO-OFDM WDM PON with DM-VCSEL for femtocells application

    DEFF Research Database (Denmark)

    Binti Othman, Maisara; Deng, Lei; Pang, Xiaodan

    2011-01-01

    We report on experimental demonstration of 2x2 MIMO-OFDM 5.6-GHz radio over fiber signaling over 20 km WDM-PON with directly modulated (DM) VCSELs for femtocells application. MIMO-OFDM algorithms effectively compensate for impairments in the wireless link. Error-free signal demodulation of 64...

  4. Effect of DM Actuator Errors on the WFIRST/AFTA Coronagraph Contrast Performance

    Science.gov (United States)

    Sidick, Erkin; Shi, Fang

    2015-01-01

    The WFIRST/AFTA 2.4 m space telescope currently under study includes a stellar coronagraph for the imaging and the spectral characterization of extrasolar planets. The coronagraph employs two sequential deformable mirrors (DMs) to compensate for phase and amplitude errors in creating dark holes. DMs are critical elements in high contrast coronagraphs, requiring precision and stability measured in picometers to enable detection of Earth-like exoplanets. Working with a low-order wavefront-sensor the DM that is conjugate to a pupil can also be used to correct low-order wavefront drift during a scientific observation. However, not all actuators in a DM have the same gain. When using such a DM in low-order wavefront sensing and control subsystem, the actuator gain errors introduce high-spatial frequency errors to the DM surface and thus worsen the contrast performance of the coronagraph. We have investigated the effects of actuator gain errors and the actuator command digitization errors on the contrast performance of the coronagraph through modeling and simulations, and will present our results in this paper.

  5. DISCOVERY OF LOW DM FAST RADIO TRANSIENTS: GEMINGA PULSAR CAUGHT IN THE ACT

    Energy Technology Data Exchange (ETDEWEB)

    Maan, Yogesh, E-mail: ymaan@ncra.tifr.res.in [National Centre for Radio Astrophysics, Pune 411007 (India)

    2015-12-20

    We report the discovery of several energetic radio bursts at 34 MHz, using the Gauribidanur radio telescope. The radio bursts exhibit two important properties associated with the propagation of astronomical signals through the interstellar medium: (i) frequency dependent dispersive delays across the observing bandwidth and (ii) Faraday rotation of the plane of linear polarization. These bursts sample a range of dispersion measures (DM; 1.4–3.6 pc cm{sup −3}) and show DM-variation at timescales of the order of a minute. Using groups of bursts having a consistent DM, we show that the bursts have originated from the radio-quiet gamma-ray pulsar Geminga. Detection of these bursts supports the existence of occasional radio emission from Geminga. The rare occurrence of these bursts, and the short timescale variation in their DM (if really caused by the intervening medium or the pulsar magnetosphere), might provide clues as to why the pulsar has not been detected in earlier sensitive searches. We present details of the observations and search procedure used to discover these bursts, a detailed analysis of their properties, and evidences of these bursts being associated with Geminga pulsar, and briefly discuss the possible emission mechanism of these bursts.

  6. Studies on the s_dm.t=f verb form in Classical Egyptian

    NARCIS (Netherlands)

    Zonhoven, Ludovicus Martinus Johannes

    1997-01-01

    This study is devoted to some synchronic aspects of the sDm.t=f verb form, primarily its meaning and uses in Classical Egyptian. In the introduction some attention is paid to the history of the studies of the form and its origin, an aspect which will receive no further consideration. In accordance

  7. The Argon Dark Matter Experiment

    CERN Document Server

    AUTHOR|(CDS)2071720

    2009-01-01

    The ArDM experiment, a 1 ton liquid argon TPC/Calorimeter, is designed for the detection of dark matter particles which can scatter off the spinless argon nucleus, producing nuclear recoils. These events will be discerned by their light to charge ratio, as well as the time structure of the scintillation light. The experiment is presently under construction and commissioning on surface at CERN. Cryogenic operation and light detection performance was recently confirmed in a test run of the full 1 ton liquid argon target under purely calorimetric operation and with a prototype light readout system. This note describes the experimental concept, the main detector components and presents some first results.

  8. Dark Matter

    Indian Academy of Sciences (India)

    What You See Ain't What. You Got, Resonance, Vol.4,. No.9,1999. Dark Matter. 2. Dark Matter in the Universe. Bikram Phookun and Biman Nath. In Part 11 of this article we learnt that there are compelling evidences from dynamics of spiral galaxies, like our own, that there must be non-luminous matter in them. In this.

  9. Particle Dark Matter Searches Outside the Local Group

    Science.gov (United States)

    Regis, Marco; Xia, Jun-Qing; Cuoco, Alessandro; Branchini, Enzo; Fornengo, Nicolao; Viel, Matteo

    2015-06-01

    If dark matter (DM) is composed by particles which are nongravitationally coupled to ordinary matter, their annihilations or decays in cosmic structures can result in detectable radiation. We show that the most powerful technique to detect a particle DM signal outside the Local Group is to study the angular cross-correlation of nongravitational signals with low-redshift gravitational probes. This method allows us to enhance the signal to noise from the regions of the Universe where the DM-induced emission is preferentially generated. We demonstrate the power of this approach by focusing on GeV-TeV DM and on the recent cross-correlation analysis between the 2MASS galaxy catalogue and the Fermi-LAT γ -ray maps. We show that this technique is more sensitive than other extragalactic γ -ray probes, such as the energy spectrum and angular autocorrelation of the extragalactic background, and emission from clusters of galaxies. Intriguingly, we find that the measured cross-correlation can be well fitted by a DM component, with a thermal annihilation cross section and mass between 10 and 100 GeV, depending on the small-scale DM properties and γ -ray production mechanism. This solicits further data collection and dedicated analyses.

  10. TREX-DM: a low-background Micromegas-based TPC for low-mass WIMP detection

    Energy Technology Data Exchange (ETDEWEB)

    Iguaz, F.J.; Garza, J.G.; Castel, J.F.; Cebrian, S.; Dafni, T.; Garcia, J.A.; Irastorza, I.G.; Lagraba, A.; Luzon, G.; Peiro, A. [Universidad de Zaragoza, Grupo de Fisica Nuclear y Astroparticulas, Zaragoza (Spain); Aznar, F. [Universidad de Zaragoza, Grupo de Fisica Nuclear y Astroparticulas, Zaragoza (Spain); Universidad de Zaragoza, Centro Universitario de la Defensa, Zaragoza (Spain)

    2016-10-15

    If Dark Matter is made of Weakly Interacting Massive Particles (WIMPs) with masses below ∝20 GeV, the corresponding nuclear recoils in mainstream WIMP experiments are of energies too close, or below, the experimental threshold. Gas Time Projection Chambers (TPCs) can be operated with a variety of target elements, offer good tracking capabilities and, on account of the amplification in gas, very low thresholds are achievable. Recent advances in electronics and in novel radiopure TPC readouts, especially micro-mesh gas structure (Micromegas), are improving the scalability and low-background prospects of gaseous TPCs. Here we present TREX-DM, a prototype to test the concept of a Micromegas-based TPC to search for low-mass WIMPs. The detector is designed to host an active mass of ∝0.300 kg of Ar at 10 bar, or alternatively ∝0.160 kg of Ne at 10 bar, with an energy threshold below 0.4 keVee, and is fully built with radiopure materials. We will describe the detector in detail, the results from the commissioning phase on surface, as well as a preliminary background model. The anticipated sensitivity of this technique may go beyond current experimental limits for WIMPs of masses of 2-8 GeV. (orig.)

  11. Decaying dark matter and the PAMELA anomaly

    International Nuclear Information System (INIS)

    Ibarra, Alejandro; Tran, David

    2009-01-01

    Astrophysical and cosmological observations do not require the dark matter particles to be absolutely stable. If they are indeed unstable, their decay into positrons might occur at a sufficiently large rate to allow the indirect detection of dark matter through an anomalous contribution to the cosmic positron flux. In this paper we discuss the implications of the excess in the positron fraction recently reported by the PAMELA collaboration for the scenario of decaying dark matter. To this end, we have performed a model-independent analysis of possible signatures by studying various decay channels in the case of both a fermionic and a scalar dark matter particle. We find that the steep rise in the positron fraction measured by PAMELA at energies larger than 10 GeV can naturally be accommodated in several realizations of the decaying dark matter scenario. The data point toward a rather heavy dark matter particle, m DM ∼> 300 GeV, which preferentially decays directly into first or second generation charged leptons with a lifetime τ DM ∼ 10 26 s

  12. Higgs naturalness and dark matter stability by scale invariance

    Directory of Open Access Journals (Sweden)

    Jun Guo

    2015-09-01

    Full Text Available Extending the spacetime symmetries of standard model (SM by scale invariance (SI may address the Higgs naturalness problem. In this article we attempt to embed accidental dark matter (DM into SISM, requiring that the symmetry protecting DM stability is accidental due to the model structure rather than imposed by hand. In this framework, if the light SM-like Higgs boson is the pseudo Goldstone boson of SI spontaneously breaking, we can even pine down the model, two-Higgs-doublets plus a real singlet: The singlet is the DM candidate and the extra Higgs doublet triggers electroweak symmetry breaking via the Coleman–Weinberg mechanism; Moreover, it dominates DM dynamics. We study spontaneously breaking of SI using the Gillard–Weinberg approach and find that the second doublet should acquire vacuum expectation value near the weak scale. Moreover, its components should acquire masses around 380 GeV except for a light CP-odd Higgs boson. Based on these features, we explore viable ways to achieve the correct relic density of DM, facing stringent constraints from direct detections of DM. For instance, DM annihilates into bb¯ near the SM-like Higgs boson pole, or into a pair of CP-odd Higgs boson with mass above that pole.

  13. Constraints on dark matter annihilation from CMB observations before Planck

    Energy Technology Data Exchange (ETDEWEB)

    Lopez-Honorez, Laura [Theoretische Natuurkunde, Vrije Universiteit Brussel and The International Solvay Institutes, Pleinlaan 2, B-1050 Brussels (Belgium); Mena, Olga; Palomares-Ruiz, Sergio; Vincent, Aaron C., E-mail: llopezho@vub.ac.be, E-mail: omena@ific.uv.es, E-mail: sergio.palomares.ruiz@ist.utl.pt, E-mail: vincent@ific.uv.es [Instituto de Física Corpuscular (IFIC), CSIC-Universitat de València, Apartado de Correos 22085, E-46071 Valencia (Spain)

    2013-07-01

    We compute the bounds on the dark matter (DM) annihilation cross section using the most recent Cosmic Microwave Background measurements from WMAP9, SPT'11 and ACT'10. We consider DM with mass in the MeV–TeV range annihilating 100% into either an e{sup +}e{sup −} or a μ{sup +}μ{sup −} pair. We consider a realistic energy deposition model, which includes the dependence on the redshift, DM mass and annihilation channel. We exclude the canonical thermal relic abundance cross section ((σv) = 3 × 10{sup −26}cm{sup 3}s{sup −1}) for DM masses below 30 GeV and 15 GeV for the e{sup +}e{sup −} and μ{sup +}μ{sup −} channels, respectively. A priori, DM annihilating in halos could also modify the reionization history of the Universe at late times. We implement a realistic halo model taken from results of state-of-the-art N-body simulations and consider a mixed reionization mechanism, consisting on reionization from DM as well as from first stars. We find that the constraints on DM annihilation remain unchanged, even when large uncertainties on the halo model parameters are considered.

  14. Excited Dark Matter versus PAMELA/Fermi

    CERN Document Server

    Cline, James M

    2010-01-01

    Excitation of multicomponent dark matter in the galactic center has been proposed as the source of low-energy positrons that produce the excess 511 keV gamma rays that have been observed by INTEGRAL. Such models have also been promoted to explain excess high-energy electrons/positrons observed by the PAMELA, Fermi/LAT and H.E.S.S. experiments. We investigate whether one model can simultaneously fit all three anomalies, in addition to further constraints from inverse Compton scattering by the high-energy leptons. We find models that fit both the 511 keV and PAMELA excesses at dark matter masses M < 400 GeV, but not the Fermi lepton excess. The conflict arises because a more cuspy DM halo profile is needed to match the observed 511 keV signal than is compatible with inverse Compton constraints at larger DM masses.

  15. Higgsino-like dark matter from sneutrino late decays

    Directory of Open Access Journals (Sweden)

    Anibal D. Medina

    2017-07-01

    Full Text Available We consider Higgsino-like dark matter (DM in the Minimal Supersymmetric Standard Model (MSSM with additional right-handed neutrino chiral superfields, and propose a new non-thermal way of generating the right amount of relic DM via sneutrino late decays. Due to the large DM annihilation cross-section, decays must occur at lower temperatures than the freeze-out temperature Td≪TF,χ˜10∼μ/25, implying a mostly right-handed lightest sneutrino with very small Yukawa interactions. In that context, the right amount of Higgsino-like DM relic density can be accounted for if sneutrinos are produced via thermal freeze-in in the early Universe.

  16. How to save the WIMP. Global analysis of a dark matter model with two s-channel mediators

    International Nuclear Information System (INIS)

    Duerr, Michael; Kahlhoefer, Felix; Schmidt-Hoberg, Kai; Schwetz, Thomas; Vogl, Stefan

    2016-06-01

    A reliable comparison of different dark matter (DM) searches requires models that satisfy certain consistency requirements like gauge invariance and perturbative unitarity. As a well-motivated example, we study two-mediator DM (2MDM). The model is based on a spontaneously broken U(1)"' gauge symmetry and contains a Majorana DM particle as well as two s-channel mediators, one vector (the Z"') and one scalar (the dark Higgs). We perform a global scan over the parameters of the model assuming that the DM relic density is obtained by thermal freeze-out in the early Universe and imposing a large set of constraints: direct and indirect DM searches, monojet, dijet and dilepton searches at colliders, Higgs observables, electroweak precision tests and perturbative unitarity. We conclude that thermal DM is only allowed either close to an s-channel resonance or if at least one mediator is lighter than the DM particle. In these cases a thermal DM abundance can be obtained although DM couplings to the Standard Model are tiny. Interestingly, we find that vector-mediated DM-nucleon scattering leads to relevant constraints despite the velocity-suppressed cross section, and that indirect detection can be important if DM annihilations into both mediators are kinematically allowed.

  17. The Effects of Admixed Dark Matter on Accretion Induced Collapse

    Science.gov (United States)

    Leung, Shing-Chi; Chu, Ming-Chung; Lin, Lap-Ming; Nomoto, Ken'ichi

    About 90% mass of matter in the universe is dark matter (DM) and most of its properties remain poorly constrained since it does not interact with electromagnetic and strong forces. To constrain the properties of DM, studying its effects on stellar objects is one of the methods. In [Leung et al., Phys. Rev. D 87, 123506 (2013); Leung et al., Astrophys. J. 812, 110 (2015)] we have shown that the dark matter admixture can significantly lower the Chandrasekhar mass of a white dwarf and also its corresponding explosion as a Type Ia supernova (SNe Ia). This type of objects may explain some observed sub-luminous SNe Ia. Depending on their stellar evolution path and interactions with companion stars, such objects can also undergo a direct collapse to form neutron stars (NSs) instead of explosion. Here we present results of one-dimensional hydrodynamics simulations of a NS with admixed DM. The DM is assumed to be asymmetric and in the form of an ideal degenerate Fermi gas. We study how the admixture of DM affects the collapse dynamics, its neutrino signals and the properties of the proto-NS. Possible observational signals are also discussed.

  18. Two variants on T2DM susceptible gene HHEX are associated with CRC risk in a Chinese population.

    Science.gov (United States)

    Sun, Rui; Liu, Jian-Ping; Gao, Chang; Xiong, Ying-Ying; Li, Min; Wang, Ya-Ping; Su, Yan-Wei; Lin, Mei; Jiang, An-Li; Xiong, Ling-Fan; Xie, Yan; Feng, Jue-Ping

    2016-05-17

    Increasing amounts of evidence has demonstrated that T2DM (Type 2 Diabetes Mellitus) patients have increased susceptibility to CRC (colorectal cancer). As HHEX is a recognized susceptibility gene in T2DM, this work was focused on two SNPs in HHEX, rs1111875 and rs7923837, to study their association with CRC. T2DM patients without CRC (T2DM-only, n=300), T2DM with CRC (T2DM/CRC, n=135), cancer-free controls (Control, n=570), and CRC without T2DM (CRC-only, n=642) cases were enrolled. DNA samples were extracted from the peripheral blood leukocytes of the patients and sequenced by direct sequencing. The χ2 test was used to compare categorical data. We found that in T2DM patients, rs1111875 but not the rs7923837 in HHEX gene was associated with the occurrence of CRC (p= 0.006). for rs1111875, TC/CC patients had an increased risk of CRC (p=0.019, OR=1.592, 95%CI=1.046-2.423). Moreover, our results also indicated that the two variants of HEEX gene could be risk factors for CRC in general population, independent on T2DM (pCRC was observed in TC or TC/CC than CC individuals (pCRC risk was observed in AG, GG, and AG/GG than AA individuals (pCRC susceptibility. Risk effects and the functional impact of these polymorphisms need further validation.

  19. The nature of dark matter

    Energy Technology Data Exchange (ETDEWEB)

    Kirillov, A.A. [Institute for Applied Mathematics and Cybernetics, 10 Uljanova Str., Nizhny Novgorod 603005 (Russian Federation)]. E-mail: ka98@mail.ru

    2006-01-19

    The observed strong dark-to-luminous matter coupling [F. Donato, et al., astro-ph/0403206, Mon. Not. R. Astron. Soc., submitted for publication; G. Gentile, et al., Mon. Not. R. Astron. Soc. 351 (2004) 903; D.T.F. Weldrake, et al., Mon. Not. R. Astron. Soc. 340 (2003) 12; W.J.G. de Blok, A. Bosma, Astron. Astrophys. 385 (2002) 816; O. Gerhard, et al., Astrophys. J. 121 (2001) 1936; A. Borriello, et al., Mon. Not. R. Astron. Soc. 341 (2003) 1109] suggests the existence of a some functional relation between visible and DM sources which leads to biased Einstein equations. We show that such a bias appears in the case when the topological structure of the actual Universe at very large distances does not match properly that of the Friedman space. We introduce a bias operator {rho}{sub DM}=B-bar {rho}{sub vis} and show that the simple bias function b=1/(4{pi}r{sub 0}r{sup 2}){theta}(r-r{sub max}) (the kernel of B-bar ) allows to account for all the variety of observed DM halos in astrophysical systems. In galaxies such a bias forms the cored DM distribution with the radius R{sub C}{approx}R{sub opt} (which explains the recently observed strong correlation between R{sub C} and R{sub opt} [F. Donato, et al., astro-ph/0403206, Mon. Not. R. Astron. Soc., submitted for publication]), while for a point source it produces the logarithmic correction to the Newton's potential (which explains the observed flat rotation curves in spirals). Finally, we show that in the theory suggested the galaxy formation process leads to a specific variation with time of all interaction constants and, in particular, of the fine structure constant.

  20. Search for Light Dark Matter Produced in a Proton Beam Dump

    Energy Technology Data Exchange (ETDEWEB)

    Thornton, Remington Tyler [Indiana Univ., Bloomington, IN (United States)

    2017-01-01

    Cosmological observations indicate that our universe contains dark matter (DM), yet we have no measurements of its microscopic properties. Whereas the gravitational interaction of DM is well understood, its interaction with the Standard Model is not. Direct detection experiments, the current standard, search for a nuclear recoil interaction and have a low-mass sensitivity edge of order 1 GeV. A path to detect DM with mass below 1 GeV is the use of accelerators producing boosted low-mass DM. Using neutrino detectors to search for low-mass DM is logical due to the similarity of the DM and neutrino signatures in the detector. The MiniBooNE experiment, located at Fermilab on the Booster Neutrino Beamline, has produced the first proton beam-dump light DM search results. Using dark matter scattering from nucleons 90% confidence limits were set over a large parameter space and, to allow tests of other theories, a model independent DM rate was extracted.

  1. Apoastron shift constraints on dark matter distribution at the Galactic Center

    International Nuclear Information System (INIS)

    Zakharov, A. F.; Nucita, A. A.; De Paolis, F.; Ingrosso, G.

    2007-01-01

    The existence of dark matter (DM) at scales of a few parsecs down to ≅10 -5 pc around the centers of galaxies and, in particular, in the Galactic Center region has been considered in the literature. Under the assumption that such a DM clump, principally constituted by nonbaryonic matter (like weakly interacting massive particles) does exist at the center of our galaxy, the study of the γ-ray emission from the Galactic Center region allows us to constrain both the mass and the size of this DM sphere. Further constraints on the DM distribution parameters may be derived by observations of bright infrared stars around the Galactic Center. Hall and Gondolo [J. Hall and P. Gondolo, Phys. Rev. D 74, 063511 (2006)] used estimates of the enclosed mass obtained in various ways and tabulated by Ghez et al. [A. M. Ghez et al., Astron. Nachr. 324, 527 (2003); A. M. Ghez et al., Astrophys. J. 620, 744 (2005)]. Moreover, if a DM cusp does exist around the Galactic Center it could modify the trajectories of stars moving around it in a sensible way depending on the DM mass distribution. Here, we discuss the constraints that can be obtained with the orbit analysis of stars (as S2 and S16) moving inside the DM concentration with the present and next generations of large telescopes. In particular, consideration of the S2 star apoastron shift may allow improving limits on the DM mass and size

  2. Dark Matter in γ lines: Galactic Center vs. dwarf galaxies

    Energy Technology Data Exchange (ETDEWEB)

    Lefranc, Valentin; Moulin, Emmanuel [DRF/Irfu, Service de Physique des Particules, CEA Saclay, F-91191 Gif-Sur-Yvette Cedex (France); Panci, Paolo; Silk, Joseph [Institut d' Astrophysique de Paris, UMR 7095 CNRS, Université Pierre et Marie Curie, 98 bis Boulevard Arago, Paris 75014 (France); Sala, Filippo, E-mail: valentin.lefranc@cea.fr, E-mail: emmanuel.moulin@cea.fr, E-mail: panci@iap.fr, E-mail: fsala@lpthe.jussieu.fr, E-mail: silk@iap.fr [LPTHE, UMR 7589 CNRS, 4 Place Jussieu, F-75252, Paris (France)

    2016-09-01

    We provide CTA sensitivities to Dark Matter (DM) annihilation in γ-ray lines, from the observation of the Galactic Center (GC) as well as, for the first time, of dwarf Spheroidal galaxies (dSphs). We compare the GC reach with that of dSphs as a function of a putative core radius of the DM distribution, which is itself poorly known. We find that the currently best dSph candidates constitute a more promising target than the GC, for core radii of one to a few kpc. We use the most recent instrument response functions and background estimations by CTA, on top of which we add the diffuse photon component. Our analysis is of particular interest for TeV-scale electroweak multiplets as DM candidates, such as the supersymmetric Wino and the Minimal Dark Matter fiveplet, whose predictions we compare with our projected sensitivities.

  3. Resistance to Downy Mildew in Lettuce 'La Brillante' is Conferred by Dm50 Gene and Multiple QTL.

    Science.gov (United States)

    Simko, Ivan; Ochoa, Oswaldo E; Pel, Mathieu A; Tsuchida, Cayla; Font I Forcada, Carolina; Hayes, Ryan J; Truco, Maria-Jose; Antonise, Rudie; Galeano, Carlos H; Michelmore, Richard W

    2015-09-01

    Many cultivars of lettuce (Lactuca sativa L.) are susceptible to downy mildew, a nearly globally ubiquitous disease caused by Bremia lactucae. We previously determined that Batavia type cultivar 'La Brillante' has a high level of field resistance to the disease in California. Testing of a mapping population developed from a cross between 'Salinas 88' and La Brillante in multiple field and laboratory experiments revealed that at least five loci conferred resistance in La Brillante. The presence of a new dominant resistance gene (designated Dm50) that confers complete resistance to specific isolates was detected in laboratory tests of seedlings inoculated with multiple diverse isolates. Dm50 is located in the major resistance cluster on linkage group 2 that contains at least eight major, dominant Dm genes conferring resistance to downy mildew. However, this Dm gene is ineffective against the isolates of B. lactucae prevalent in the field in California and the Netherlands. A quantitative trait locus (QTL) located at the Dm50 chromosomal region (qDM2.2) was detected, though, when the amount of disease was evaluated a month before plants reached harvest maturity. Four additional QTL for resistance to B. lactucae were identified on linkage groups 4 (qDM4.1 and qDM4.2), 7 (qDM7.1), and 9 (qDM9.2). The largest effect was associated with qDM7.1 (up to 32.9% of the total phenotypic variance) that determined resistance in multiple field experiments. Markers identified in the present study will facilitate introduction of these resistance loci into commercial cultivars of lettuce.

  4. Decoherence as a way to measure extremely soft collisions with dark matter

    Science.gov (United States)

    Riedel, C. Jess; Yavin, Itay

    2017-07-01

    A new frontier in the search for dark matter (DM) is based on the idea of detecting the decoherence caused by DM scattering against a mesoscopic superposition of normal matter. Such superpositions are uniquely sensitive to very small momentum transfers from new particles and forces, especially DM with a mass below 100 MeV. Here we investigate what sorts of dark sectors are inaccessible with existing methods but would induce noticeable decoherence in the next generation of matter interferometers. We show that very soft but medium range (0.1 nm - 1 μ m ) elastic interactions between nuclei and DM are particularly suitable. We construct toy models for such interactions, discuss existing constraints, and delineate the expected sensitivity of forthcoming experiments. The first hints of DM in these devices would appear as small variations in the anomalous decoherence rate with a period of one sidereal day. This is a generic signature of interstellar sources of decoherence, clearly distinguishing it from terrestrial backgrounds. The OTIMA experiment under development in Vienna will begin to probe Earth-thermalizing DM once sidereal variations in the background decoherence rate are pushed below one part in a hundred for superposed 5-nm gold nanoparticles. The proposals by Bateman et al. and Geraci et al. could be similarly sensitive although they would require at least a month of data taking. DM that is absorbed or elastically reflected by the Earth, and so avoids a greenhouse density enhancement, would not be detectable by those three experiments. On the other hand, the aggressive proposals of the MAQRO collaboration and Pino et al. would immediately open up many orders of magnitude in DM mass, interaction range, and coupling strength, regardless of how DM behaves in bulk matter.

  5. D matter

    International Nuclear Information System (INIS)

    Shiu, Gary; Wang Liantao

    2004-01-01

    We study the properties and phenomenology of particlelike states originating from D branes whose spatial dimensions are all compactified. They are nonperturbative states in string theory and we refer to them as D matter. In contrast to other nonperturbative objects such as 't Hooft-Polyakov monopoles, D-matter states could have perturbative couplings among themselves and with ordinary matter. The lightest D particle (LDP) could be stable because it is the lightest state carrying certain (integer or discrete) quantum numbers. Depending on the string scale, they could be cold dark matter candidates with properties similar to that of WIMPs or wimpzillas. The spectrum of excited states of D matter exhibits an interesting pattern which could be distinguished from that of Kaluza-Klein modes, winding states, and string resonances. We speculate about possible signatures of D matter from ultrahigh energy cosmic rays and colliders

  6. Role of miRNAs in Epicardial Adipose Tissue in CAD Patients with T2DM

    Directory of Open Access Journals (Sweden)

    Yang Liu

    2016-01-01

    Full Text Available Background. Epicardial adipose tissue (EAT is identified as an atypical fat depot surrounding the heart with a putative role in the involvement of metabolic disorders, including obesity, type-2 diabetes mellitus, and atherosclerosis. We profiled miRNAs in EAT of metabolic patients with coronary artery disease (CAD and type-2 diabetes mellitus (T2DM versus metabolically healthy patients by microarray. Compared to metabolically healthy patients, we identified forty-two miRNAs that are differentially expressed in patients with CAD and T2DM from Xinjiang, China. Eleven miRNAs were selected as potential novel miRNAs according to P value and fold change. Then the potential novel miRNAs targeted genes were predicted via TargetScan, PicTar, and miRTarbase, and the function of the target genes was predicted via Gene Ontology (GO analysis while the enriched KEGG pathway analyses of the miRNAs targeted genes were performed by bioinformatics software DAVID. Then protein-protein interaction networks of the targeted gene were conducted by online software STRING. Finally, using microarray, bioinformatics approaches revealed the possible molecular mechanisms pathogenesis of CAD and T2DM. A total of 11 differentially expressed miRNAs were identified and among them, hsa-miR-4687-3p drew specific attention. Bioinformatics analysis revealed that insulin signaling pathway is the central way involved in the progression of metabolic disorders. Conclusions. The current findings support the fact that miRNAs are involved in the pathogenesis of metabolic disorders in EAT of CAD patients with T2DM, and validation of the results of these miRNAs by independent and prospective study is certainly warranted.

  7. Sensitive limits on the abundance of cold water vapor in the DM Tauri protoplanetary disk

    NARCIS (Netherlands)

    Bergin, E. A.; Hogerheijde, M. R.; Brinch, C.; Fogel, J.; Yildiz, U. A.; Kristensen, L. E.; van Dishoeck, E. F.; Bell, T. A.; Blake, G.A.; Cernicharo, J.; Dominik, C.; Lis, D.; Melnick, G.; Neufeld, D.; Panic, O.; Pearson, J. C.; Bachiller, R.; Baudry, A.; Benedettini, M.; Benz, A. O.; Bjerkeli, P.; Bontemps, S.; Braine, J.; Bruderer, S.; Caselli, P.; Codella, C.; Daniel, F.; di Giorgio, A. M.; Doty, S. D.; Encrenaz, P.; Fich, M.; Fuente, A.; Giannini, T.; Goicoechea, J. R.; de Graauw, Th.; Helmich, F.; Herczeg, G. J.; Herpin, F.; Jacq, T.; Johnstone, D.; Jorgensen, J. K.; Larsson, B.; Liseau, R.; Marseille, M.; Mc Coey, C.; Nisini, B.; Olberg, M.; Parise, B.; Plume, R.; Risacher, C.; Santiago-Garcia, J.; Saraceno, P.; Shipman, R.; Tafalla, M.; van Kempen, T. A.; Visser, R.; Wampfler, S. F.; Wyrowski, F.; van der Tak, F.; Jellema, W.; Tielens, A. G. G. M.; Hartogh, P.; Stuetzki, J.; Szczerba, R.

    2010-01-01

    We performed a sensitive search for the ground-state emission lines of ortho-and para-water vapor in the DM Tau protoplanetary disk using the Herschel/HIFI instrument. No strong lines are detected down to 3 sigma levels in 0.5 km s(-1) channels of 4.2 mK for the 1(10)-1(01) line and 12.6 mK for the

  8. Safety Basis Report

    International Nuclear Information System (INIS)

    R.J. Garrett

    2002-01-01

    As part of the internal Integrated Safety Management Assessment verification process, it was determined that there was a lack of documentation that summarizes the safety basis of the current Yucca Mountain Project (YMP) site characterization activities. It was noted that a safety basis would make it possible to establish a technically justifiable graded approach to the implementation of the requirements identified in the Standards/Requirements Identification Document. The Standards/Requirements Identification Documents commit a facility to compliance with specific requirements and, together with the hazard baseline documentation, provide a technical basis for ensuring that the public and workers are protected. This Safety Basis Report has been developed to establish and document the safety basis of the current site characterization activities, establish and document the hazard baseline, and provide the technical basis for identifying structures, systems, and components (SSCs) that perform functions necessary to protect the public, the worker, and the environment from hazards unique to the YMP site characterization activities. This technical basis for identifying SSCs serves as a grading process for the implementation of programs such as Conduct of Operations (DOE Order 5480.19) and the Suspect/Counterfeit Items Program. In addition, this report provides a consolidated summary of the hazards analyses processes developed to support the design, construction, and operation of the YMP site characterization facilities and, therefore, provides a tool for evaluating the safety impacts of changes to the design and operation of the YMP site characterization activities

  9. Safety Basis Report

    Energy Technology Data Exchange (ETDEWEB)

    R.J. Garrett

    2002-01-14

    As part of the internal Integrated Safety Management Assessment verification process, it was determined that there was a lack of documentation that summarizes the safety basis of the current Yucca Mountain Project (YMP) site characterization activities. It was noted that a safety basis would make it possible to establish a technically justifiable graded approach to the implementation of the requirements identified in the Standards/Requirements Identification Document. The Standards/Requirements Identification Documents commit a facility to compliance with specific requirements and, together with the hazard baseline documentation, provide a technical basis for ensuring that the public and workers are protected. This Safety Basis Report has been developed to establish and document the safety basis of the current site characterization activities, establish and document the hazard baseline, and provide the technical basis for identifying structures, systems, and components (SSCs) that perform functions necessary to protect the public, the worker, and the environment from hazards unique to the YMP site characterization activities. This technical basis for identifying SSCs serves as a grading process for the implementation of programs such as Conduct of Operations (DOE Order 5480.19) and the Suspect/Counterfeit Items Program. In addition, this report provides a consolidated summary of the hazards analyses processes developed to support the design, construction, and operation of the YMP site characterization facilities and, therefore, provides a tool for evaluating the safety impacts of changes to the design and operation of the YMP site characterization activities.

  10. Dark Matter

    International Nuclear Information System (INIS)

    Holt, S. S.; Bennett, C. L.

    1995-01-01

    These proceedings represent papers presented at the Astrophysics conference in Maryland, organized by NASA Goddard Space Flight Center and the University of Maryland. The topics covered included low mass stars as dark matter, dark matter in galaxies and clusters, cosmic microwave background anisotropy, cold and hot dark matter, and the large scale distribution and motions of galaxies. There were eighty five papers presented. Out of these, 10 have been abstracted for the Energy Science and Technology database

  11. PROFIL URINALISIS PENGGUNAAN IMUNAX PADA PASIEN DIABETES MELITUS (DM RAWAT JALAN DI RSU PKU MUHAMMADIYAH BANTUL

    Directory of Open Access Journals (Sweden)

    Adnan

    2018-03-01

    Full Text Available Diabetes mellitus (DM is a metabolic disease characterized by the onset of hyperglycemia due to secretion disorders, as well as resistance of insulin. Chronic hyperglycemic and other DM metabolic disorders will cause tissue and organ damage, such as the eyes, kidneys and vascular system. Some studies show that immunax (MBJH: minyak biji jinten hitam has antidibetic benefits. This study aims to determine the description of urinalysis and proteinuria in DM patients who get immunax. The study design was randomized controlled trial. MBJH is given in 2 dosage levels, 2x1 soft capsule and 2x2 soft capsul given for 20 days on the subject. Urine data taken before and after administration of immunax preparations. The results showed that based on sex, age, education, occupation, marital status and the type of therapy used there was no significant difference in the characteristics and types of therapy used by the study subjects (patients at risk of metabolic syndrome between the treatment groups and the placebo group. The result of urinalysis test showed that there was no difference of urinalysis image in the three groups. The conclusion of this study was that there was no significant effect (p value> 0,05 on immunax (MBJH on the urinalysis profile in patients with metabolic syndrome risk, both dose 2x1, 2x2, and control group

  12. Protective mechanisms against oxidative stress and angiopathy in young patients with diabetes type 1 (DM1).

    Science.gov (United States)

    Koutroumani, Nikolitsa; Partsalaki, Ioanna; Lamari, Fotini; Dettoraki, Athina; Gil, Andrea Paola Rojas; Karvela, Alexia; Kostopoulou, Eirini; Spiliotis, Bessie E

    2013-01-01

    Advanced glycation end-products (AGEs) via their receptor, RAGE, are involved in diabetic angiopathy. Soluble RAGE, an inhibitor of this axis, is formed by enzymatic catalysis (sRAGE) or alternative splicing (esRAGE). Malondialdehyde (MDA) is an oxidative stress marker, and ferric reducing ability of plasma (FRAP) is an anti-oxidant capacity marker. In isolated mononuclear blood cells from 110 DM1-patients (P) and 124 controls (C) (4-29 years) RAGE mRNA (g) and protein expression (pe) were measured by RT-PCR and Western immunoblotting, respectively. Plasma levels of CML (AGEs) and sRAGE were measured by ELISA, MDA by flurometry and FRAP according to 'Benzie and Strain'. P showed: (i) higher g of RAGE, especially in p>13 years of age and >5 years DM1, (ii) increased pe of esRAGE in DM1>5 years and (iii) increased FRAP and MDA. The increased esRAGE and FRAP with increased levels of CML and MDA possibly reflects a protective response against the formation of diabetic complications in these young diabetic patients.

  13. Effect of Exercise on Psychological Well-being in T2DM

    Directory of Open Access Journals (Sweden)

    Farzad Najafipoor

    2011-09-01

    Full Text Available Background: Type 2 diabetic patients (T2DM experience health problems including psychiatric and psychological complications that influence their general health. Since exercise has an additional effect on psychological improvement, we aimed to establish the role of exercise as improvement of psychological problems. Methods: 80 subjects with T2DM were assigned to take exercise for 90 minutes per session, 3 times a week for a period of 4 months. They answered the GHQ-12 questionnaire before and after the study project. Results: Questionnaires were scored by Likert model and entered the statistical analysis. Our findings demonstrate a significant decrease in the mean GHQ-12 scores. [13.39 ± 5.89 to 8.52 ± 5.12 (p < 0.001]. Factor analysis by Graetz's three-factor model suggests that factor I (anxiety and depression associates with more improvement than the other factors.Conclusion: Exercise improves psychological distress in T2DM and results in improved well-being.

  14. Physico-Mechanical Properties of Coprocessed Excipient MicroceLac® 100 by DM(3) Approach.

    Science.gov (United States)

    Haware, Rahul V; Kancharla, Joseph P; Udupa, Aishwarya K; Staton, Scott; Gupta, Mali R; Al-Achi, Antoine; Stagner, William C

    2015-11-01

    To determine the effect of relative humidity (RH) and hydroxypropyl methylcellulose (HPMC) on the physico-mechanical properties of coprocessed MacroceLac(®) 100 using 'DM(3)' approach. Effects of RH and 5% w/w HPMC on MacroceLac(®) 100 Compressibility Index (CI) and tablet mechanical strength (TMS) were evaluated by 'DM(3)'. The 'DM(3)' approach evaluates material properties by combining 'design of experiments', material's 'macroscopic' properties, 'molecular' properties, and 'multivariate analysis' tools. A 4X4 full-factorial experimental design was used to study the relationship of MacroceLac(®) 100 molecular properties (moisture content, dehydration, crystallization, fusion enthalpy, and moisture uptake) and macroscopic particle size and shape on CI and TMS. A physical binary mixture (PBM) of similar composition to MacroceLac(®) 100 was also evaluated. Multivariate analysis of variance (MANOVA), principle component analysis, and partial least squares (PLS) were used to analyze the data. MANOVA CI ranking was: PBM-HPMC > PBM > MicroceLac(®)100 > MicroceLac(®)100-HPMC (p TMS values were lower than MicroceLac(®)100 and MicroceLac(®)100-HPMC (p TMS. Significant MicroceLac(®)100 changes occurred with % RH exposure affecting performance attributes. HPMC physical addition did not prevent molecular or macroscopic matrix changes.

  15. Anti-listerial Bactericidal Activity of Lactobacillus plantarum DM5 Isolated from Fermented Beverage Marcha.

    Science.gov (United States)

    Das, Deeplina; Goyal, Arun

    2013-09-01

    The strain Lactobacillus plantarum DM5 was isolated from fermented beverage Marcha of Sikkim and explored for its antagonistic activity against food-borne pathogens. The cell-free supernatant of L. plantarum DM5 showed antibacterial activity of 6,400 AU/mL in MRS medium (pH 6.0) against the indicator strain Staphylococcus aureus. MRS medium supplemented with 15 g/L of maltose at 37 °C under static condition yielded highest antimicrobial activity (6,400 AU/mL) with 3 % increase in specific activity when compared to 20 g/L glucose. The antimicrobial compound was heat stable (60 min at 100 °C) and was active over a wide pH range. It showed bactericidal effect on S. aureus and Listeria monocytogenes by causing 96 and 98 % of cell lysis, respectively. The cell morphology of the treated S. aureus and L. monocytogenes was completely deformed as revealed by scanning electron microscopy, suggesting the high potential of L. plantarum DM5 as natural preservatives in food industry. The antimicrobial compound was purified by 80 % ammonium sulphate precipitation and showed antimicrobial activity of 12,800 AU/mL with 19-fold purification and a molecular mass of 15.2 kDa, indicating the proteinaceous nature of the compound.

  16. A functional polymorphism of the TNF-α gene that is associated with type 2 DM

    International Nuclear Information System (INIS)

    Susa, Shinji; Daimon, Makoto; Sakabe, Jun-Ichi; Sato, Hidenori; Oizumi, Toshihide; Karasawa, Shigeru; Wada, Kiriko; Jimbu, Yumi; Kameda, Wataru; Emi, Mitsuru; Muramatsu, Masaaki; Kato, Takeo

    2008-01-01

    To examine the association of the tumor necrosis factor-α (TNF-α) gene region with type 2 diabetes (DM), 11 single-nucleotide polymorphisms (SNPs) of the region were analyzed. The initial study using a sample set (148 cases vs. 227 controls) showed a significant association of the SNP IVS1G + 123A of the TNF-α gene with DM (p = 0.0056). Multiple logistic regression analysis using an enlarged sample set (225 vs. 716) revealed the significant association of the SNP with DM independently of any clinical traits examined (OR: 1.49, p = 0.014). The functional relevance of the SNP were examined by the electrophoretic mobility shift assays using nuclear extracts from the U937 and NIH3T3 cells and luciferase assays in these cells with Simian virus 40 promoter- and TNF-α promoter-reporter gene constructs. The functional analyses showed that YY1 transcription factor bound allele-specifically to the SNP region and, the IVS1 + 123A allele had an increase in luciferase expression compared with the G allele

  17. IMPROVING SELF-CARE INDEPENDENCY OF TYPE 2 DM PATIENTS BASED ON LASALLIAN EDUCATION MODEL

    Directory of Open Access Journals (Sweden)

    Annastasia Sintia Lamonge

    2016-09-01

    Full Text Available Abstract The specific objectives of this study were: (1 Analyze the effectiveness of Lasallian health education in order to increased knowledge and attitude. (2 Analyze the effectiveness of Lasallian health education in order to increase the self-care independency of people with type 2 diabetes mellitus (DM. Research design of this study was  Pre-Experiment with target population patients with type 2 DM. 12 participants were recruited in the study with  purposive sampling technique. Bivariate test results of knowledge and attitudes before and after giving the Lasallian health education showed significant results with ρ-value of 0.016 (p-value <ά 0.05. Research result of self-care independency of type 2 diabetic patients in before and after giving Lasallian health education show significant result with ρ-value of 0.001 (p-value <ά 0:01. Transformation of people behavior or habit by a health education program should have three important determinant, there are cognitive,  affective and psychomotor aspects of participants to motivate and increase self-awareness, and adherence of self-care management and improving of quality of life. Keywords: Type 2 DM, Lasallian Health Education, Knowledge, Attitude, Self-care independency.

  18. Dark Matter

    International Nuclear Information System (INIS)

    Bashir, A.; Cotti, U.; De Leon, C. L.; Raya, A; Villasenor, L.

    2008-01-01

    One of the biggest scientific mysteries of our time resides in the identification of the particles that constitute a large fraction of the mass of our Universe, generically known as dark matter. We review the observations and the experimental data that imply the existence of dark matter. We briefly discuss the properties of the two best dark-matter candidate particles and the experimental techniques presently used to try to discover them. Finally, we mention a proposed project that has recently emerged within the Mexican community to look for dark matter

  19. On the evaporation of solar dark matter: spin-independent effective operators

    Energy Technology Data Exchange (ETDEWEB)

    Liang, Zheng-Liang [Institute of High Energy Physics, Chinese Academy of Sciences,19B Yuquan Road, Beijing, 100049 (China); Wu, Yue-Liang; Yang, Zi-Qing; Zhou, Yu-Feng [Kavli Institute for Theoretical Physics China,CAS Key Laboratory of Theoretical Physics, Institute of Theoretical Physics,Chinese Academy of Sciences, Zhong Guan Cun Street 55#, Beijing, 100190 (China)

    2016-09-13

    As a part of the effort to investigate the implications of dark matter (DM)-nucleon effective interactions on the solar DM detection, in this paper we focus on the evaporation of the solar DM for a set of the DM-nucleon spin-independent (SI) effective operators. In order to put the evaluation of the evaporation rate on a more reliable ground, we calculate the non-thermal distribution of the solar DM using the Monte Carlo methods, rather than adopting the Maxwellian approximation. We then specify relevant signal parameter spaces for the solar DM detection for various SI effective operators. Based on the analysis, we determine the minimum DM masses for which the DM-nucleon coupling strengths can be probed from the solar neutrino observations. As an interesting application, our investigation also shows that evaporation effect can not be neglectd in a recent proposal aiming to solve the solar abundance problem by invoking the momentum-dependent asymmetric DM in the Sun.

  20. On the evaporation of solar dark matter: spin-independent effective operators

    International Nuclear Information System (INIS)

    Liang, Zheng-Liang; Wu, Yue-Liang; Yang, Zi-Qing; Zhou, Yu-Feng

    2016-01-01

    As a part of the effort to investigate the implications of dark matter (DM)-nucleon effective interactions on the solar DM detection, in this paper we focus on the evaporation of the solar DM for a set of the DM-nucleon spin-independent (SI) effective operators. In order to put the evaluation of the evaporation rate on a more reliable ground, we calculate the non-thermal distribution of the solar DM using the Monte Carlo methods, rather than adopting the Maxwellian approximation. We then specify relevant signal parameter spaces for the solar DM detection for various SI effective operators. Based on the analysis, we determine the minimum DM masses for which the DM-nucleon coupling strengths can be probed from the solar neutrino observations. As an interesting application, our investigation also shows that evaporation effect can not be neglectd in a recent proposal aiming to solve the solar abundance problem by invoking the momentum-dependent asymmetric DM in the Sun.

  1. Searching for dark matter signals in the left-right symmetric gauge model with CP symmetry

    International Nuclear Information System (INIS)

    Guo Wanlei; Wu Yueliang; Zhou Yufeng

    2010-01-01

    We investigate the singlet scalar dark matter (DM) candidate in a left-right symmetric gauge model with two Higgs bidoublets in which the stabilization of the DM particle is induced by the discrete symmetries P and CP. According to the observed DM abundance, we predict the DM direct and indirect detection cross sections for the DM mass range from 10 to 500 GeV. We show that the DM indirect detection cross section is not sensitive to the light Higgs mixing and Yukawa couplings except for the resonance regions. The predicted spin-independent DM-nucleon elastic scattering cross section is found to be significantly dependent on the above two factors. Our results show that the future DM direct search experiments can cover the most parts of the allowed parameter space. The PAMELA antiproton data can only exclude two very narrow regions in the two Higgs bidoublets model. It is very difficult to detect the DM direct or indirect signals in the resonance regions due to the Breit-Wigner resonance effect.

  2. Inelastic dark matter, non-standard halos and the DAMA/LIBRA results

    International Nuclear Information System (INIS)

    March-Russell, John; McCabe, Christopher; McCullough, Matthew

    2009-01-01

    The DAMA collaboration have claimed to detect particle dark matter (DM) via an annual modulation in their observed recoil event rate. This appears to be in strong disagreement with the null results of other experiments if interpreted in terms of elastic DM scattering, while agreement for a small region of parameter space is possible for inelastic DM (iDM) due to the altered kinematics of the collision. To date most analyses assume a simple galactic halo DM velocity distribution, the Standard Halo Model, but direct experimental support for the SHM is severely lacking and theoretical studies indicate possible significant differences. We investigate the dependence of DAMA and the other direct detection experiments on the local DM velocity distribution, utilizing the results of the Via Lactea and Dark Disc numerical simulations. We also investigate effects of varying the solar circular velocity, the DM escape velocity, and the DAMA quenching factor within experimental limits. Our data set includes the latest ZEPLIN-III results, as well as full publicly available data sets. Due to the more sensitive dependence of the inelastic cross section on the velocity distribution, we find that with Via Lactea the DAMA results can be consistent with all other experiments over an enlarged region of iDM parameter space, with higher mass particles being preferred, while Dark Disc does not lead to an improvement. A definitive test of DAMA for iDM requires heavy element detectors.

  3. JST Thesaurus Headwords and Synonyms: T1DM [MeCab user dictionary for science technology term[Archive

    Lifescience Database Archive (English)

    Full Text Available MeCab user dictionary for science technology term T1DM 名詞 一般 * * * * 1型糖尿病 1ガタトウニョウビョウ イチガタトーニョービョー Thesaurus2015 200906052809193540 C LS51 UNKNOWN_2 T 1 DM

  4. Properties of galactic dark matter: Constraints from astronomical observations

    International Nuclear Information System (INIS)

    Burch, B.; Cowsik, R.

    2013-01-01

    The distributions of normal matter and of dark matter in the Galaxy are coupled to each other as they both move in the common gravitational potential. In order to fully exploit this interplay and to derive the various properties of dark matter relevant to their direct and indirect detection, we have comprehensively reviewed the astronomical observations of the spatial and velocity distributions of the components of normal matter. We then postulate that the phase-space distribution of dark matter follows a lowered-isothermal form and self-consistently solve Poisson's equation to construct several models for the spatial and velocity distributions of dark matter. In this paper, we compute the total gravitational potential of the normal and dark matter components and investigate their consistency with current observations of the rotation curve of the Galaxy and of the spatial and velocity distributions of blue horizontal-branch and blue straggler stars. Even with this demand of consistency, a large number of models with a range of parameters characterizing the dark matter distribution remain. We find that the best choice of parameters, within the range of allowed values for the surface density of the disk 55 M ☉ pc –2 , are the following: the dark matter density at the Galactic center ρ DM, c ≈ 100-250 GeV cm –3 , the local dark matter density ρ DM (R 0 ) ≈ 0.56-0.72 GeV cm –3 , and the rms speed of dark matter particles 〈v DM 2 (R 0 )〉 1/2 ≈490−−550 km s –1 . We also discuss possible astronomical observations that may further limit the range of the allowed models. The predictions of the allowed models for direct and indirect detection will be discussed separately in a companion paper.

  5. Dry matter intake and digestibility of temperate pastures ...

    African Journals Online (AJOL)

    The aim of this study was to evaluate the effect of sorghum grain supplementation on total and forage dry matter (DM) intake and digestibility of wethers and heifers consuming temperate pasture. Twenty four Corriedale x Milchschaf wethers and 24 crossbred heifers fed temperate pasture were non-supplemented or ...

  6. Helioseismology with long-range dark matter-baryon interactions

    DEFF Research Database (Denmark)

    Lopes, I.; Panci, Paolo; Silk, J.

    2014-01-01

    Assuming the existence of a primordial asymmetry in the dark sector, we study how long-range dark matter (DM)-baryon interactions, induced by the kinetic mixing of a new U(1) gauge boson and a photon, affect the evolution of the Sun and, in turn, the sound speed the profile obtained from...

  7. Muon Flux Limits for Majorana Dark Matter Particles

    DEFF Research Database (Denmark)

    Belotsky, Konstantin; Khlopov, Maxim; Kouvaris, Christoforos

    2009-01-01

    We analyze the effects of capture of dark matter (DM) particles, with successive annihilations, predicted in the minimal walking technicolor model (MWT) by the Sun and the Earth. We show that the Super-Kamiokande (SK) upper limit on excessive muon flux disfavors the mass interval between 100-200 Ge...

  8. Testing Structure Formation in the Universe via Coupled Matter Fluids

    African Journals Online (AJOL)

    kagoyire

    the universe is dominated by two “dark” components- dark matter. (DM) and dark energy (DE)- that contribute about 26% and 69% respectively to the total cosmic energy budget, raises key questions about the nature of the “dark-sector” and large-scale structure formation (Planck Collaboration XVI, 2014). Motivated by a ...

  9. Supersymmetric dark matter after LHC run 1

    International Nuclear Information System (INIS)

    Bagnaschi, E.A.; Buchmueller, O.; Cavanaugh, R.; Illinois Univ., Chicago, IL

    2015-08-01

    Different mechanisms operate in various regions of the MSSM parameter space to bring the relic density of the lightest neutralino, χ 0 1 , assumed here to be the LSP and thus the Dark Matter (DM) particle, into the range allowed by astrophysics and cosmology. These mechanisms include coannihilation with some nearly-degenerate next-to-lightest supersymmetric particle (NLSP) such as the lighter stau τ 1 , stop t 1 or chargino χ ± 1 , resonant annihilation via direct-channel heavy Higgs bosons H/A, the light Higgs boson h or the Z boson, and enhanced annihilation via a larger Higgsino component of the LSP in the focus-point region. These mechanisms typically select lower-dimensional subspaces in MSSM scenarios such as the CMSSM, NUHM1, NUHM2 and pMSSM10. We analyze how future LHC and direct DM searches can complement each other in the exploration of the different DM mechanisms within these scenarios. We find that the τ 1 coannihilation regions of the CMSSM, NUHM1, NUHM2 can largely be explored at the LHC via searches for missing E T events and long-lived charged particles, whereas their H/A funnel, focus-point and χ ± 1 coannihilation regions can largely be explored by the LZ and Darwin DM direct detection experiments. We find that the dominant DM mechanism in our pMSSM10 analysis is χ ± 1 coannihilation: parts of its parameter space can be explored by the LHC, and a larger portion by future direct DM searches.

  10. Late decaying 2-component dark matter scenario as an explanation of the AMS-02 positron excess

    Energy Technology Data Exchange (ETDEWEB)

    Buch, Jatan; Ralegankar, Pranjal; Rentala, Vikram, E-mail: jatan_buch@brown.edu, E-mail: pranjal6@illinois.edu, E-mail: rentala@phy.iitb.ac.in [Department of Physics, Indian Institute of Technology - Bombay, Powai, Mumbai 400076 (India)

    2017-10-01

    The long standing anomaly in the positron flux as measured by the PAMELA and AMS-02 experiments could potentially be explained by dark matter (DM) annihilations. This scenario typically requires a large 'boost factor' to be consistent with a thermal relic dark matter candidate produced via freeze-out. However, such an explanation is disfavored by constraints from CMB observations on energy deposition during the epoch of recombination. We discuss a scenario called late-decaying two-component dark matter (LD2DM), where the entire DM consists of two semi-degenerate species. Within this framework, the heavier species is produced as a thermal relic in the early universe and decays to the lighter species over cosmological timescales. Consequently, the lighter species becomes the DM which populates the universe today. We show that annihilation of the lighter DM species with an enhanced cross-section, produced via such a non-thermal mechanism, can explain the observed AMS-02 positron flux while avoiding CMB constraints. The observed DM relic density can be correctly reproduced as well with simple s -wave annihilation cross-sections. We demonstrate that the scenario is safe from CMB constraints on late-time energy depositions during the cosmic 'dark ages'. Interestingly, structure formation constraints force us to consider small mass splittings between the two dark matter species. We explore possible cosmological and particle physics signatures in a toy model that realizes this scenario.

  11. Late decaying 2-component dark matter scenario as an explanation of the AMS-02 positron excess

    International Nuclear Information System (INIS)

    Buch, Jatan; Ralegankar, Pranjal; Rentala, Vikram

    2017-01-01

    The long standing anomaly in the positron flux as measured by the PAMELA and AMS-02 experiments could potentially be explained by dark matter (DM) annihilations. This scenario typically requires a large 'boost factor' to be consistent with a thermal relic dark matter candidate produced via freeze-out. However, such an explanation is disfavored by constraints from CMB observations on energy deposition during the epoch of recombination. We discuss a scenario called late-decaying two-component dark matter (LD2DM), where the entire DM consists of two semi-degenerate species. Within this framework, the heavier species is produced as a thermal relic in the early universe and decays to the lighter species over cosmological timescales. Consequently, the lighter species becomes the DM which populates the universe today. We show that annihilation of the lighter DM species with an enhanced cross-section, produced via such a non-thermal mechanism, can explain the observed AMS-02 positron flux while avoiding CMB constraints. The observed DM relic density can be correctly reproduced as well with simple s -wave annihilation cross-sections. We demonstrate that the scenario is safe from CMB constraints on late-time energy depositions during the cosmic 'dark ages'. Interestingly, structure formation constraints force us to consider small mass splittings between the two dark matter species. We explore possible cosmological and particle physics signatures in a toy model that realizes this scenario.

  12. Halo-independent direct detection of momentum-dependent dark matter

    DEFF Research Database (Denmark)

    Cherry, J. F.; Frandsen, M. T.; Shoemaker, I. M.

    2014-01-01

    We show that the momentum dependence of dark matter interactions with nuclei can be probed in direct detection experiments without knowledge of the dark matter velocity distribution. This is one of the few properties of DM microphysics that can be determined with direct detection alone, given...... a signal of dark matter in multiple direct detection experiments with different targets. Long-range interactions arising from the exchange of a light mediator are one example of momentum-dependent DM. For data produced from the exchange of a massless mediator we find for example that the mediator mass can...

  13. Supernova cooling in a dark matter smog

    International Nuclear Information System (INIS)

    Zhang, Yue

    2014-01-01

    A light hidden gauge boson with kinetic mixing with the usual photon is a popular setup in theories of dark matter. The supernova cooling via radiating the hidden boson is known to put an important constraint on the mixing. I consider the possible role dark matter, which under reasonable assumptions naturally exists inside supernova, can play in the cooling picture. Because the interaction between the hidden gauge boson and DM is likely unsuppressed, even a small number of dark matter compared to protons inside the supernova could dramatically shorten the free streaming length of the hidden boson. A picture of a dark matter “smog” inside the supernova, which substantially relaxes the cooling constraint, is discussed in detail

  14. Supernova cooling in a dark matter smog

    Energy Technology Data Exchange (ETDEWEB)

    Zhang, Yue [Walter Burke Institute for Theoretical Physics, California Institute of Technology, Pasadena, CA 91125 (United States)

    2014-11-27

    A light hidden gauge boson with kinetic mixing with the usual photon is a popular setup in theories of dark matter. The supernova cooling via radiating the hidden boson is known to put an important constraint on the mixing. I consider the possible role dark matter, which under reasonable assumptions naturally exists inside supernova, can play in the cooling picture. Because the interaction between the hidden gauge boson and DM is likely unsuppressed, even a small number of dark matter compared to protons inside the supernova could dramatically shorten the free streaming length of the hidden boson. A picture of a dark matter “smog” inside the supernova, which substantially relaxes the cooling constraint, is discussed in detail.

  15. Supernova cooling in a dark matter smog

    Energy Technology Data Exchange (ETDEWEB)

    Zhang, Yue, E-mail: yuezhang@theory.caltech.edu [Walter Burke Institute for Theoretical Physics, California Institute of Technology, Pasadena, CA 91125 (United States)

    2014-11-01

    A light hidden gauge boson with kinetic mixing with the usual photon is a popular setup in theories of dark matter. The supernova cooling via radiating the hidden boson is known to put an important constraint on the mixing. I consider the possible role dark matter, which under reasonable assumptions naturally exists inside supernova, can play in the cooling picture. Because the interaction between the hidden gauge boson and DM is likely unsuppressed, even a small number of dark matter compared to protons inside the supernova could dramatically shorten the free streaming length of the hidden boson. A picture of a dark matter ''smog'' inside the supernova, which substantially relaxes the cooling constraint, is discussed in detail.

  16. Self-interacting asymmetric dark matter coupled to a light massive dark photon

    International Nuclear Information System (INIS)

    Petraki, Kalliopi; Pearce, Lauren; Kusenko, Alexander

    2014-01-01

    Dark matter (DM) with sizeable self-interactions mediated by a light species offers a compelling explanation of the observed galactic substructure; furthermore, the direct coupling between DM and a light particle contributes to the DM annihilation in the early universe. If the DM abundance is due to a dark particle-antiparticle asymmetry, the DM annihilation cross-section can be arbitrarily large, and the coupling of DM to the light species can be significant. We consider the case of asymmetric DM interacting via a light (but not necessarily massless) Abelian gauge vector boson, a dark photon. In the massless dark photon limit, gauge invariance mandates that DM be multicomponent, consisting of positive and negative dark ions of different species which partially bind in neutral dark atoms. We argue that a similar conclusion holds for light dark photons; in particular, we establish that the multi-component and atomic character of DM persists in much of the parameter space where the dark photon is sufficiently light to mediate sizeable DM self-interactions. We discuss the cosmological sequence of events in this scenario, including the dark asymmetry generation, the freeze-out of annihilations, the dark recombination and the phase transition which gives mass to the dark photon. We estimate the effect of self-interactions in DM haloes, taking into account this cosmological history. We place constraints based on the observed ellipticity of large haloes, and identify the regimes where DM self-scattering can affect the dynamics of smaller haloes, bringing theory in better agreement with observations. Moreover, we estimate the cosmological abundance of dark photons in various regimes, and derive pertinent bounds

  17. Emergence of the mass discrepancy-acceleration relation from dark matter-baryon interactions

    Science.gov (United States)

    Famaey, Benoit; Khoury, Justin; Penco, Riccardo

    2018-03-01

    The observed tightness of the mass discrepancy-acceleration relation (MDAR) poses a fine-tuning challenge to current models of galaxy formation. We propose that this relation could arise from collisional interactions between baryons and dark matter (DM) particles, without the need for modification of gravity or ad hoc feedback processes. We assume that these interactions satisfy the following three conditions: (i) the relaxation time of DM particles is comparable to the dynamical time in disk galaxies; (ii) DM exchanges energy with baryons due to elastic collisions; (iii) the product between the baryon-DM cross section and the typical energy exchanged in a collision is inversely proportional to the DM number density. As a proof of principle, we present an example of a particle physics model that gives a DM-baryon cross section with the desired density and velocity dependence. For consistency with direct detection constraints, our DM particles must be either very light (m ll mb) or very heavy (mgg mb), corresponding respectively to heating and cooling of DM by baryons. In both cases, our mechanism applies and an equilibrium configuration can in principle be reached. In this exploratory paper, we focus on the heavy DM/cooling case because it is technically simpler, since the average energy exchanged turns out to be approximately constant throughout galaxies. Under these assumptions, we find that rotationally-supported disk galaxies could naturally settle to equilibrium configurations satisfying a MDAR at all radii without invoking finely tuned feedback processes. We also discuss issues related to the small scale clumpiness of baryons, as well as predictions for pressure-supported systems. We argue in particular that galaxy clusters do not follow the MDAR despite being DM-dominated because they have not reached their equilibrium configuration. Finally, we revisit existing phenomenological, astrophysical and cosmological constraints on baryon-DM interactions in light

  18. DM100 AND DM1200 MELTER TESTING WITH HIGH WASTE LOADING FORMULATIONS FOR HANFORD HIGH-ALUMINUM HLW STREAMS, TEST PLAN 09T1690-1

    International Nuclear Information System (INIS)

    Kruger, A.A.; Matlack, K.S.; Kot, W.K.; Pegg, I.L.; Joseph, I.

    2009-01-01

    This Test Plan describes work to support the development and testing of high waste loading glass formulations that achieve high glass melting rates for Hanford high aluminum high level waste (HLW). In particular, the present testing is designed to evaluate the effect of using low activity waste (LAW) waste streams as a source of sodium in place ofchemical additives, sugar or cellulose as a reductant, boehmite as an aluminum source, and further enhancements to waste processing rate while meeting all processing and product quality requirements. The work will include preparation and characterization of crucible melts in support of subsequent DuraMelter 100 (DM 100) tests designed to examine the effects of enhanced glass formulations, glass processing temperature, incorporation of the LAW waste stream as a sodium source, type of organic reductant, and feed solids content on waste processing rate and product quality. Also included is a confirmatory test on the HLW Pilot Melter (DM1200) with a composition selected from those tested on the DM100. This work builds on previous work performed at the Vitreous State Laboratory (VSL) for Department of Energy's (DOE's) Office of River Protection (ORP) to increase waste loading and processing rates for high-iron HLW waste streams as well as previous tests conducted for ORP on the same waste composition. This Test Plan is prepared in response to an ORP-supplied statement of work. It is currently estimated that the number of HLW canisters to be produced in the Hanford Tank Waste Treatment and Immobilization Plant (WTP) is about 12,500. This estimate is based upon the inventory ofthe tank wastes, the anticipated performance of the sludge treatment processes, and current understanding of the capability of the borosilicate glass waste form. The WTP HLW melter design, unlike earlier DOE melter designs, incorporates an active glass bubbler system. The bubblers create active glass pool convection and thereby improve heat transfer and

  19. On wave dark matter in spiral and barred galaxies

    International Nuclear Information System (INIS)

    Martinez-Medina, Luis A.; Matos, Tonatiuh; Bray, Hubert L.

    2015-01-01

    We recover spiral and barred spiral patterns in disk galaxy simulations with a Wave Dark Matter (WDM) background (also known as Scalar Field Dark Matter (SFDM), Ultra-Light Axion (ULA) dark matter, and Bose-Einstein Condensate (BEC) dark matter). Here we show how the interaction between a baryonic disk and its Dark Matter Halo triggers the formation of spiral structures when the halo is allowed to have a triaxial shape and angular momentum. This is a more realistic picture within the WDM model since a non-spherical rotating halo seems to be more natural. By performing hydrodynamic simulations, along with earlier test particles simulations, we demonstrate another important way in which wave dark matter is consistent with observations. The common existence of bars in these simulations is particularly noteworthy. This may have consequences when trying to obtain information about the dark matter distribution in a galaxy, the mere presence of spiral arms or a bar usually indicates that baryonic matter dominates the central region and therefore observations, like rotation curves, may not tell us what the DM distribution is at the halo center. But here we show that spiral arms and bars can develop in DM dominated galaxies with a central density core without supposing its origin on mechanisms intrinsic to the baryonic matter

  20. New probe of dark-matter properties: gravitational waves from an intermediate-mass black hole embedded in a dark-matter minispike.

    Science.gov (United States)

    Eda, Kazunari; Itoh, Yousuke; Kuroyanagi, Sachiko; Silk, Joseph

    2013-05-31

    An intermediate-mass black hole (IMBH) may have a dark-matter (DM) minihalo around it and develop a spiky structure within less than a parsec from the IMBH. When a stellar mass object is captured by the minihalo, it eventually infalls into such an IMBH due to gravitational wave backreaction which in turn could be observed directly by future space-borne gravitational wave experiments such as eLISA and NGO. In this Letter, we show that the gravitational wave (GW) detectability strongly depends on the radial profile of the DM distribution. So if the GW is detected, the power index, that is, the DM density distribution, would be determined very accurately. The DM density distribution obtained would make it clear how the IMBH has evolved from a seed black hole and whether the IMBH has experienced major mergers in the past. Unlike the γ-ray observations of DM annihilation, GW is just sensitive to the radial profile of the DM distribution and even to noninteracting DM. Hence, the effect we demonstrate here can be used as a new and powerful probe into DM properties.

  1. Unifying leptogenesis, dark matter and high-energy neutrinos with right-handed neutrino mixing via Higgs portal

    Energy Technology Data Exchange (ETDEWEB)

    Bari, Pasquale Di; Ludl, Patrick Otto [Physics and Astronomy, University of Southampton, Southampton, SO17 1BJ (United Kingdom); Palomares-Ruiz, Sergio [Instituto de Física Corpuscular (IFIC), CSIC-Universitat de València,Apartado de Correos 22085, E-46071 Valencia (Spain)

    2016-11-21

    We revisit a model in which neutrino masses and mixing are described by a two right-handed (RH) neutrino seesaw scenario, implying a strictly hierarchical light neutrino spectrum. A third decoupled RH neutrino, N{sub DM} with mass M{sub DM}, plays the role of cold dark matter (DM) and is produced by the mixing with a source RH neutrino, N{sub S} with mass M{sub S}, induced by Higgs portal interactions. The same interactions are also responsible for N{sub DM} decays. We discuss in detail the constraints coming from DM abundance and stability conditions showing that in the hierarchical case, for M{sub DM}≫M{sub S}, there is an allowed window on M{sub DM} values necessarily implying a contribution, from DM decays, to the high-energy neutrino flux recently detected by IceCube. We also show how the model can explain the matter-antimatter asymmetry of the Universe via leptogenesis in the quasi-degenerate limit. In this case, the DM mass should be within the range 300 GeV ≲M{sub S}DM}≲ 10 PeV. We discuss the specific properties of this high-energy neutrino flux and show the predicted event spectrum for two exemplary cases. Although DM decays, with a relatively hard spectrum, cannot account for all the IceCube high-energy data, we illustrate how this extra source of high-energy neutrinos could reasonably explain some potential features in the observed spectrum. In this way, this represents a unified scenario for leptogenesis and DM that could be tested during the next years with more high-energy neutrino events.

  2. Tau flavored dark matter and its impact on tau Yukawa coupling

    Energy Technology Data Exchange (ETDEWEB)

    Chao, Wei [Center for Advanced Quantum Studies, Department of Physics, Beijing Normal University, Beijing, 100875 China (China); Guo, Huai-Ke; Li, Hao-Lin, E-mail: chao@physics.umass.edu, E-mail: huaike@physics.umass.edu, E-mail: haolinli@physics.umass.edu [Amherst Center for Fundamental Interactions, Department of Physics, University of Massachusetts-Amherst, 710 N Pleasant St., Amherst, MA, 01003 (United States)

    2017-02-01

    In this paper we perform a systematic study of the tau flavored dark matter (DM) model by introducing two kinds of mediators (a scalar doublet and a charged scalar singlet). The electromagnetic properties of the DM, as well as their implications in DM direct detections, are analyzed in detail. The model turns out contributing a significant radiative correction to the tau lepton mass, in addition to loosing the tension between the measured DM relic density and constraints of DM direct detections. The loop corrections can be O(10%) of the total tau mass. Signal rates of the Higgs measurements from the LHC in the h →τ τ and h → γ γ channels, relative to the Standard Model expectations, can be explained in this model.

  3. Gravitational waves as a new probe of Bose–Einstein condensate Dark Matter

    Directory of Open Access Journals (Sweden)

    P.S. Bhupal Dev

    2017-10-01

    Full Text Available There exists a class of ultralight Dark Matter (DM models which could give rise to a Bose–Einstein condensate (BEC in the early universe and behave as a single coherent wave instead of individual particles in galaxies. We show that a generic BEC-DM halo intervening along the line of sight of a gravitational wave (GW signal could induce an observable change in the speed of GWs, with the effective refractive index depending only on the mass and self-interaction of the constituent DM particles and the GW frequency. Hence, we propose to use the deviation in the speed of GWs as a new probe of the BEC-DM parameter space. With a multi-messenger approach to GW astronomy and/or with extended sensitivity to lower GW frequencies, the entire BEC-DM parameter space can be effectively probed by our new method in the near future.

  4. Spherical cows in dark matter indirect detection

    Energy Technology Data Exchange (ETDEWEB)

    Bernal, Nicolás [Centro de Investigaciones, Universidad Antonio Nariño, Cra 3 Este # 47A-15, Bogotá (Colombia); Necib, Lina; Slatyer, Tracy R., E-mail: nicolas.bernal@uan.edu.co, E-mail: lnecib@mit.edu, E-mail: tslatyer@mit.edu [Center for Theoretical Physics, Massachusetts Institute of Technology, Cambridge, MA 02139 (United States)

    2016-12-01

    Dark matter (DM) halos have long been known to be triaxial, but in studies of possible annihilation and decay signals they are often treated as approximately spherical. In this work, we examine the asymmetry of potential indirect detection signals of DM annihilation and decay, exploiting the large statistics of the hydrodynamic simulation Illustris. We carefully investigate the effects of the baryons on the sphericity of annihilation and decay signals for both the case where the observer is at 8.5 kpc from the center of the halo (exemplified in the case of Milky Way-like halos), and for an observer situated well outside the halo. In the case of Galactic signals, we find that both annihilation and decay signals are expected to be quite symmetric, with axis ratios very different from 1 occurring rarely. In the case of extragalactic signals, while decay signals are still preferentially spherical, the axis ratio for annihilation signals has a much flatter distribution, with elongated profiles appearing frequently. Many of these elongated profiles are due to large subhalos and/or recent mergers. Comparing to gamma-ray emission from the Milky Way and X-ray maps of clusters, we find that the gamma-ray background appears less spherical/more elongated than the expected DM signal from the large majority of halos, and the Galactic gamma ray excess appears very spherical, while the X-ray data would be difficult to distinguish from a DM signal by elongation/sphericity measurements alone.

  5. Direct dark matter search with the CRESST-III experiment - status and perspectives

    Science.gov (United States)

    Willers, M.; Angloher, G.; Bento, A.; Bucci, C.; Canonica, L.; Defay, X.; Erb, A.; Feilitzsch, F. v.; Ferreiro Iachellini, N.; Gütlein, A.; Gorla, P.; Hauff, D.; Jochum, J.; Kiefer, M.; Kluck, H.; Kraus, H.; Lanfranchi, J.-C.; Loebell, J.; Mancuso, M.; Münster, A.; Pagliarone, C.; Petricca, F.; Potzel, W.; Pröbst, F.; Puig, R.; Reindl, F.; Schäffner, K.; Schieck, J.; Schönert, S.; Seidel, W.; Stahlberg, M.; Stodolsky, L.; Strandhagen, C.; Strauss, R.; Tanzke, A.; Trinh Thi, H. H.; Türkoǧlu, C.; Uffinger, M.; Ulrich, A.; Usherov, I.; Wawoczny, S.; Wüstrich, M.; Zöller, A.

    2017-09-01

    The CRESST-III experiment, located in the Gran Sasso underground laboratory (LNGS, Italy), aims at the direct detection of dark matter (DM) particles. Scintillating CaWO4 crystals operated as cryogenic detectors are used as target material for DM-nucleus scattering. The simultaneous measurement of the phonon signal from the CaWO4 crystal and of the emitted scintillation light in a separate cryogenic light detector is used to discriminate backgrounds from a possible dark matter signal. The experiment aims to significantly improve the sensitivity for low-mass (≲ 5-10 GeV/c2) DM particles by using optimized detector modules with a nuclear recoil-energy threshold ≲ 100 eV. The current status of the experiment as well as projections of the sensitivity for spin-independent DM-nucleon scattering will be presented.

  6. Imaging HER2 in response to T-DM1 therapy in breast cancer xenografts

    Energy Technology Data Exchange (ETDEWEB)

    Massicano, Adriana Vidal; Aweda, Tolulope; Marqueznostra, Bernadette; El Sayed, Reeta; Beacham, Rebecca; Lapi, Suzanne [University Of Alabama, Birmingham, AL (United States)

    2017-07-01

    Full text: Introduction: Monoclonal antibodies (mAbs) have become broadly used for the treatment of cancer because they can be engineered to bind specifically to the target and therefore typically have less toxicity compared to broad spectrum chemotherapies (Jauw YWS, Menke-van der Houven van Oordt CW, Hoekstra OS, et al. Front Pharmacol 2016, 7:1-15). Ado-trastuzumab emtansine (TDM1) is a newly approved HER2 targeted therapy which consists of a cytotoxic agent (DM1) linked to trastuzumab and has shown promising results in patients with HER2 positive metastatic breast cancer (Barok MT, Köninki M, Isola K et al. Breast Cancer Res 2011, 13:1465-5411). Although {sup 18}F-FDG is considered the gold standard in the diagnosis and staging of various types of cancer, it is a relatively non-specific marker (Janjigian YY, Viola-Villegas N, Holland JP, Divilov V, Carlin SD et al. J Nucl Med 2013;54:936-43). Alternatively, {sup 89}Zr-Pertuzumab which binds to a different epitope than trastuzumab on the HER2 receptor has shown high selectively in imaging variations in HER2 expression in breast cancer xenograft models (Marquez BV, Ikotun OF, Zheleznyak A, Wright B et al. Mol Pharm 2014;11:3988-95). Therefore, in this work, we investigated the specificity of {sup 89}Zr-Pertuzumab compared to {sup 18}F-FDG to identify early response to ado-trastuzumab emtansine (T-DM1) in a breast cancer xenograft model. Methods: Pertuzumab was conjugated top-NCS-Bz-DFO at varying molar ratios and labeled with {sup 89}Zr in different conditions. The optimal conditions were used in further in vitro and in vivo studies. In vivo PET imaging was conducted in nude female mice implanted with 17β-estradiol pellets and inoculated with 1 x 107 BT-474 HER2 positive breast cancer cells. In order to acquire baseline images, mice were injected via tail-vein with 200 μCi of 18F-FDG and imaged after 1 hour. The following day, they were injected with 100 μCi of {sup 89}Zr-Pertuzumab (20 μCi/μg) imaged 5

  7. Amino acid profile of metabolisable protein in lactating dairy cows is affected by dry matter concentration in grass-clover silage

    DEFF Research Database (Denmark)

    Johansen, Marianne; Lund, Peter; Weisbjerg, Martin Riis

    2018-01-01

    Our previous study showed that supply of metabolisable protein (MP) to lactating dairy cows increased with increasing dry matter (DM) concentration in grass-clover silage. The aim of this study was to examine how amino acid (AA) profile of MP was affected by silage DM concentration. Eight grass-c...

  8. Regional gray matter volume mediates the relationship between maternal emotional warmth and gratitude.

    Science.gov (United States)

    Yang, Junyi; Wei, Dongtao; Wang, Kangcheng; Yi, Zili; Qiu, Jiang

    2018-01-31

    Researchers have examined how parenting behavior influences individuals' brain structure and behavioral development, primarily among people who have experienced maltreatment. However, information relating to the anatomical structure associated with the parenting behavior in young healthy individuals who have not experienced maltreatment is scant. Gratitude is an important aspect of human sociality. Both the extent to which parenting behavior influences gratitude and the neural basis of the relationship between parenting behavior and gratitude are unclear. Thus, in the present study, the primary aim was to use voxel-based morphometry (VBM) to investigate the neuroanatomical basis of parenting behavior in young healthy participants. The results showed a significant negative correlation between the maternal emotional warmth and both the dorsal medial prefrontal cortex (dmPFC) and the lateral rostral prefrontal cortex. Then, we used mediation analysis to investigate the neural basis of the relationship between parenting behavior and gratitude. The results revealed that the volume of the lateral rostral prefrontal cortex mediates the relationship between the maternal emotional warmth and gratitude. Together, these findings suggest that the family environment, specifically parenting behavior, might be associated with the gray matter volume of brain structure. Further, the lateral rostral prefrontal cortex might have an important role in the relationship between the maternal emotional warmth and gratitude. Copyright © 2017 Elsevier Ltd. All rights reserved.

  9. Torsion as a dark matter candidate from the Higgs portal

    Science.gov (United States)

    Belyaev, Alexander S.; Thomas, Marc C.; Shapiro, Ilya L.

    2017-05-01

    Torsion is a metric-independent component of gravitation, which may provide a more general geometry than the one taking place within general relativity. On the other hand, torsion could lead to interesting phenomenology in both particle physics and cosmology. In the present work it is shown that a torsion field interacting with the SM Higgs doublet and having a negligible coupling to standard model (SM) fermions is protected from decaying by a Z2 symmetry, and therefore becomes a promising dark matter (DM) candidate. This model provides a good motivation for Higgs portal vector DM scenario. We evaluate the DM relic density and explore direct DM detection and collider constraints on this model to understand its consistency with experimental data and establish the most up-to-date limits on its parameter space. We have found in the model when the Higgs boson is only partly responsible for the generation of torsion mass, there is a region of parameter space where torsion contributes 100% to the DM budget of the Universe. Furthermore, we present the first results on the potential of the LHC to probe the parameter space of minimal scenario with Higgs portal vector DM using mono-jet searches and have found that LHC at high luminosity will be sensitive to the substantial part of model parameter space which cannot be probed by other experiments.

  10. Anomaly-free dark matter models are not so simple

    Science.gov (United States)

    Ellis, John; Fairbairn, Malcolm; Tunney, Patrick

    2017-08-01

    We explore the anomaly-cancellation constraints on simplified dark matter (DM) models with an extra U(1)' gauge boson Z '. We show that, if the Standard Model (SM) fermions are supplemented by a single DM fermion χ that is a singlet of the SM gauge group, and the SM quarks have non-zero U(1)' charges, the SM leptons must also have non-zero U(1)' charges, in which case LHC searches impose strong constraints on the Z ' mass. Moreover, the DM fermion χ must have a vector-like U(1)' coupling. If one requires the DM particle to have a purely axial U(1)' coupling, which would be the case if χ were a Majorana fermion and would reduce the impact of direct DM searches, the simplest possibility is that it is accompanied by one other new singlet fermion, but in this case the U(1)' charges of the SM leptons still do not vanish. This is also true in a range of models with multiple new singlet fermions with identical charges. Searching for a leptophobic model, we then introduce extra fermions that transform non-trivially under the SM gauge group. We find several such models if the DM fermion is accompanied by two or more other new fermions with non-identical charges, which may have interesting experimental signatures. We present benchmark representatives of the various model classes we discuss.

  11. Detecting electron neutrinos from solar dark matter annihilation by JUNO

    International Nuclear Information System (INIS)

    Guo, Wan-Lei

    2016-01-01

    We explore the electron neutrino signals from light dark matter (DM) annihilation in the Sun for the large liquid scintillator detector JUNO. In terms of the spectrum features of three typical DM annihilation channels χχ → νν-bar , τ + τ − , b b-bar , we take two sets of selection conditions to calculate the expected signals and atmospheric neutrino backgrounds based on the Monte Carlo simulation data. Then the JUNO sensitivities to the spin independent DM-nucleon and spin dependent DM-proton cross sections are presented. It is found that the JUNO projected sensitivities are much better than the current spin dependent direct detection experimental limits for the νν-bar and τ + τ − channels. In the spin independent case, the JUNO will give the better sensitivity to the DM-nucleon cross section than the LUX and CDMSlite limits for the νν-bar channel with the DM mass lighter than 6.5 GeV . If the νν-bar or τ + τ − channel is dominant, the future JUNO results are very helpful for us to understand the tension between the DAMA annual modulation signal and other direct detection exclusions

  12. Gravitational wave as probe of superfluid dark matter

    Science.gov (United States)

    Cai, Rong-Gen; Liu, Tong-Bo; Wang, Shao-Jiang

    2018-02-01

    In recent years, superfluid dark matter (SfDM) has become a competitive model of emergent modified Newtonian dynamics (MOND) scenario: MOND phenomenons naturally emerge as a derived concept due to an extra force mediated between baryons by phonons as a result of axionlike particles condensed as superfluid at galactic scales; Beyond galactic scales, these axionlike particles behave as normal fluid without phonon-mediated MOND-like force between baryons, therefore SfDM also maintains the usual success of Λ CDM at cosmological scales. In this paper, we use gravitational waves (GWs) to probe the relevant parameter space of SfDM. GWs through Bose-Einstein condensate (BEC) could propagate with a speed slightly deviation from the speed-of-light due to the change in the effective refractive index, which depends on the SfDM parameters and GW-source properties. We find that Five hundred meter Aperture Spherical Telescope (FAST), Square Kilometre Array (SKA) and International Pulsar Timing Array (IPTA) are the most promising means as GW probe of relevant parameter space of SfDM. Future space-based GW detectors are also capable of probing SfDM if a multimessenger approach is adopted.

  13. Hopanoid-free Methylobacterium extorquens DM4 overproduces carotenoids and has widespread growth impairment.

    Directory of Open Access Journals (Sweden)

    Alexander S Bradley

    Full Text Available Hopanoids are sterol-like membrane lipids widely used as geochemical proxies for bacteria. Currently, the physiological role of hopanoids is not well understood, and this represents one of the major limitations in interpreting the significance of their presence in ancient or contemporary sediments. Previous analyses of mutants lacking hopanoids in a range of bacteria have revealed a range of phenotypes under normal growth conditions, but with most having at least an increased sensitivity to toxins and osmotic stress. We employed hopanoid-free strains of Methylobacterium extorquens DM4, uncovering severe growth defects relative to the wild-type under many tested conditions, including normal growth conditions without additional stressors. Mutants overproduce carotenoids-the other major isoprenoid product of this strain-and show an altered fatty acid profile, pronounced flocculation in liquid media, and lower growth yields than for the wild-type strain. The flocculation phenotype can be mitigated by addition of cellulase to the medium, suggesting a link between the function of hopanoids and the secretion of cellulose in M. extorquens DM4. On solid media, colonies of the hopanoid-free mutant strain were smaller than wild-type, and were more sensitive to osmotic or pH stress, as well as to a variety of toxins. The results for M. extorquens DM4 are consistent with the hypothesis that hopanoids are important for membrane fluidity and lipid packing, but also indicate that the specific physiological processes that require hopanoids vary across bacterial lineages. Our work provides further support to emerging observations that the role of hopanoids in membrane robustness and barrier function may be important across lineages, possibly mediated through an interaction with lipid A in the outer membrane.

  14. Theoretical basis for dosimetry

    International Nuclear Information System (INIS)

    Carlsson, G.A.

    1985-01-01

    Radiation dosimetry is fundamental to all fields of science dealing with radiation effects and is concerned with problems which are often intricate as hinted above. A firm scientific basis is needed to face increasing demands on accurate dosimetry. This chapter is an attempt to review and to elucidate the elements for such a basis. Quantities suitable for radiation dosimetry have been defined in the unique work to coordinate radiation terminology and usage by the International Commission on Radiation Units and Measurements, ICRU. Basic definitions and terminology used in this chapter conform with the recent ''Radiation Quantities and Units, Report 33'' of the ICRU

  15. Gaseous Matter

    CERN Document Server

    Angelo, Joseph A

    2011-01-01

    aseous Matter focuses on the many important discoveries that led to the scientific interpretation of matter in the gaseous state. This new, full-color resource describes the basic characteristics and properties of several important gases, including air, hydrogen, helium, oxygen, and nitrogen. The nature and scope of the science of fluids is discussed in great detail, highlighting the most important scientific principles upon which the field is based. Chapters include:. Gaseous Matter An Initial Perspective. Physical Characteristics of Gases. The Rise of the Science of Gases. Kinetic Theory of

  16. Hidden charged dark matter and chiral dark radiation

    Science.gov (United States)

    Ko, P.; Nagata, Natsumi; Tang, Yong

    2017-10-01

    In the light of recent possible tensions in the Hubble constant H0 and the structure growth rate σ8 between the Planck and other measurements, we investigate a hidden-charged dark matter (DM) model where DM interacts with hidden chiral fermions, which are charged under the hidden SU(N) and U(1) gauge interactions. The symmetries in this model assure these fermions to be massless. The DM in this model, which is a Dirac fermion and singlet under the hidden SU(N), is also assumed to be charged under the U(1) gauge symmetry, through which it can interact with the chiral fermions. Below the confinement scale of SU(N), the hidden quark condensate spontaneously breaks the U(1) gauge symmetry such that there remains a discrete symmetry, which accounts for the stability of DM. This condensate also breaks a flavor symmetry in this model and Nambu-Goldstone bosons associated with this flavor symmetry appear below the confinement scale. The hidden U(1) gauge boson and hidden quarks/Nambu-Goldstone bosons are components of dark radiation (DR) above/below the confinement scale. These light fields increase the effective number of neutrinos by δNeff ≃ 0.59 above the confinement scale for N = 2, resolving the tension in the measurements of the Hubble constant by Planck and Hubble Space Telescope if the confinement scale is ≲1 eV. DM and DR continuously scatter with each other via the hidden U(1) gauge interaction, which suppresses the matter power spectrum and results in a smaller structure growth rate. The DM sector couples to the Standard Model sector through the exchange of a real singlet scalar mixing with the Higgs boson, which makes it possible to probe our model in DM direct detection experiments. Variants of this model are also discussed, which may offer alternative ways to investigate this scenario.

  17. SERUM GAMMA-GLUTAMYL TRANSFERASE AS A BIOMARKER OF TYPE-2 DM AMONG CIGARETTE SMOKERS

    Directory of Open Access Journals (Sweden)

    K. Suganthy

    2017-03-01

    Full Text Available BACKGROUND Smoking is one of the most common addictions of modern times and needs to be studied in a community as a public health issue. Also, smoking is a modifiable risk factor for type-2 DM. The smoking-related diseases share common pathophysiologies of imbalance of systemic oxidants and antioxidant status, increased inflammatory reactions, insulin resistance and dyslipidaemia. Biochemical assay of serum Gamma-Glutamyl Transferase (GGT activity is a low cost and highly sensitive laboratory test. Studies have indicated GGT is moderately elevated before the onset of other traditional risk factors for type-2 DM. So, among hepatic markers, the baseline GGT analysis can be an early risk marker of type 2 diabetes in cigarette smokers has to be studied. MATERIALS AND METHODS This is a case-control study on male cigarette smokers. 57 smokers were studied clinically and biochemically for plasma insulin, glucose and liver enzymes including GGT using standard biochemical methods and compared with 42 age and sex matched non-smokers as controls. RESULTS The mean serum GGT in smokers (25.45 ± 10.8 was increased compared to non-smokers (18.8 ± 5.8. Smokers GGT (r=0.396 and HOMA-IR (r=0.352 showed significant positive association with duration of smoking (p24 IU/L. Regression analysis showed none of the diabetic risk factors were observed to be dependent on GGT including other liver enzymes. Regression analysis showed GGT is not an independent risk factor for DM. Although, the mean fasting blood glucose (91.4 ± 21.3, BMI (26.1 ± 9.3 and HOMA-IR (7.3 ± 2.3 was increased among cigarette smokers with GGT >24 IU/L. CONCLUSION The baseline GGT assay in cigarette smokers might be associated with the proinflammatory status or be a marker of oxidative stress of smoke toxins. Smokers with baseline GGT >24 IU/L develop insulin resistance should be investigated in future longitudinal studies for prediabetes to consider cigarette smoking as an important modifiable

  18. High-contrast coronagraph performance in the presence of DM actuator defects

    Science.gov (United States)

    Sidick, Erkin; Shaklan, Stuart; Cady, Eric

    2015-09-01

    Deformable Mirrors (DMs) are critical elements in high contrast coronagraphs, requiring precision and stability measured in picometers to enable detection of Earth-like exoplanets. Occasionally DM actuators or their associated cables or electronics fail, requiring a wavefront control algorithm to compensate for actuators that may be displaced from their neighbors by hundreds of nanometers. We have carried out experiments on our High-Contrast Imaging Testbed (HCIT) to study the impact of failed actuators in partial fulfilment of the Terrestrial Planet Finder Coronagraph optical model validation milestone. We show that the wavefront control algorithm adapts to several broken actuators and maintains dark-hole contrast in broadband light.

  19. High-Contrast Coronagraph Performance in the Presence of DM Actuator Defects

    Science.gov (United States)

    Sidick, Erkin; Shaklan, Stuart; Cady, Eric

    2015-01-01

    Deformable Mirrors (DMs) are critical elements in high contrast coronagraphs, requiring precision and stability measured in picometers to enable detection of Earth-like exoplanets. Occasionally DM actuators or their associated cables or electronics fail, requiring a wavefront control algorithm to compensate for actuators that may be displaced from their neighbors by hundreds of nanometers. We have carried out experiments on our High-Contrast Imaging Testbed (HCIT) to study the impact of failed actuators in partial fulfillment of the Terrestrial Planet Finder Coronagraph optical model validation milestone. We show that the wavefront control algorithm adapts to several broken actuators and maintains dark-hole contrast in broadband light.

  20. Dry matter production and chemical composition of Massai grass submitted to nitrogen rates and cutting heights

    Directory of Open Access Journals (Sweden)

    Giselle Abadia Campos Pereira

    2016-09-01

    Full Text Available The study was carried out in a greenhouse with a 4X4 factorial arrangement randomized block design in order to evaluate the effects of nitrogen rates (0, 50, 100 and 150 mg dm-3 associated with cutting heights (10, 15, 20 and 25 cm on dry matter production and the chemical composition of Massai grass. The seeding was done in pots with 11 kg of soil. 10 plants were kept per pot, and there were two cuts every 35 days. Nitrogen fertilization was split between the two cuts, where the first N application occurred after the uniformity cut and the second after the first cut. In each cut the plants were separated and weighed for botanical component evaluation: leaf blade and stem + sheath. After this, the samples were homogenized and analysed for dry matter (DM, crude protein (CP and neutral detergent fibre (NDF content. In the first cut, the N fertilization caused a linear increase in DM production of 0.058 g pot-1 per each 1 mg dm-3 of N applied, as well as causing an increase of 0.549% in CP percentage, a 0.0124 pot-1 g increase in CP production and a reduction of 0.055% in NDF. In the second cut, N rates promoted a quadratic effect on DM production. A maximum DM production of 16.48 g pot-1 with 107.27 mg dm-3 of N was observed while CP production content was increased by 0.0092 g pot-1 for each 1 mg dm-3 N applied. In terms of linear responses to DM and PB, as well as the use efficiency calculated for Massai grass, recommended N doses range between 50 and 100 g dm-3.

  1. In vitro activity of DMG-Mino and DMG-DM Dot, two new glycylcyclines, against anaerobic bacteria.

    Science.gov (United States)

    Nord, C E; Lindmark, A; Persson, I

    1993-10-01

    The in vitro activity of DMG-Mino and DMG-DM Dot against 350 anaerobic bacterial strains including anaerobic cocci, Propionibacterium acnes, Clostridium perfringens, Clostridium difficile, Bacteroides fragilis, other Bacteroides species and fusobacteria was determined by the agar dilution method. Their activity was compared with that of minocycline, doxycycline, piperacillin, cefoxitin, imipenem, clindamycin and metronidazole. DMG-Mino and DMG-DM Dot and imipenem were the most active agents tested. DMG-Mino and DMG-DM Dot had in vitro activity superior to that of minocycline and doxycycline.

  2. From BASIS to MIRACLES

    DEFF Research Database (Denmark)

    Tsapatsaris, Nikolaos; Willendrup, Peter Kjær; E. Lechner, Ruep

    2015-01-01

    Results based on virtual instrument models for the first high-flux, high-resolution, spallation based, backscattering spectrometer, BASIS are presented in this paper. These were verified using the Monte Carlo instrument simulation packages McStas and VITESS. Excellent agreement of the neutron count...... are pivotal to the conceptual design of the next generation backscattering spectrometer, MIRACLES at the European Spallation Source....

  3. Dark matters

    International Nuclear Information System (INIS)

    Silk, Joseph

    2010-01-01

    One of the greatest mysteries in the cosmos is that it is mostly dark. That is, not only is the night sky dark, but also most of the matter and the energy in the universe is dark. For every atom visible in planets, stars and galaxies today there exists at least five or six times as much 'Dark Matter' in the universe. Astronomers and particle physicists today are seeking to unravel the nature of this mysterious but pervasive dark matter, which has profoundly influenced the formation of structure in the universe. Dark energy remains even more elusive, as we lack candidate fields that emerge from well established physics. I will describe various attempts to measure dark matter by direct and indirect means, and discuss the prospects for progress in unravelling dark energy.

  4. Dirac matter

    CERN Document Server

    Rivasseau, Vincent; Fuchs, Jean-Nöel

    2017-01-01

    This fifteenth volume of the Poincare Seminar Series, Dirac Matter, describes the surprising resurgence, as a low-energy effective theory of conducting electrons in many condensed matter systems, including graphene and topological insulators, of the famous equation originally invented by P.A.M. Dirac for relativistic quantum mechanics. In five highly pedagogical articles, as befits their origin in lectures to a broad scientific audience, this book explains why Dirac matters. Highlights include the detailed "Graphene and Relativistic Quantum Physics", written by the experimental pioneer, Philip Kim, and devoted to graphene, a form of carbon crystallized in a two-dimensional hexagonal lattice, from its discovery in 2004-2005 by the future Nobel prize winners Kostya Novoselov and Andre Geim to the so-called relativistic quantum Hall effect; the review entitled "Dirac Fermions in Condensed Matter and Beyond", written by two prominent theoreticians, Mark Goerbig and Gilles Montambaux, who consider many other mater...

  5. Direct Detection Phenomenology in Models Where the Products of Dark Matter Annihilation Interact with Nuclei

    DEFF Research Database (Denmark)

    Cherry, John F.; Frandsen, Mads T.; Shoemaker, Ian M.

    2015-01-01

    We investigate the direct detection phenomenology of a class of dark matter (DM) models in which DM does not directly interact with nuclei, {but rather} the products of its annihilation do. When these annihilation products are very light compared to the DM mass, the scattering in direct detection...... to nuclei, the limit from annihilation to relativistic particles in the Sun can be stronger than that of conventional non-relativistic direct detection by more than three orders of magnitude for masses in a 2-7 GeV window.......We investigate the direct detection phenomenology of a class of dark matter (DM) models in which DM does not directly interact with nuclei, {but rather} the products of its annihilation do. When these annihilation products are very light compared to the DM mass, the scattering in direct detection...... experiments is controlled by relativistic kinematics. This results in a distinctive recoil spectrum, a non-standard and or even absent annual modulation, and the ability to probe DM masses as low as a $\\sim$10 MeV. We use current LUX data to show that experimental sensitivity to thermal relic annihilation...

  6. Characterising dark matter searches at colliders and direct detection experiments: Vector mediators

    International Nuclear Information System (INIS)

    Buchmueller, Oliver; Dolan, Matthew J.; Malik, Sarah A.; McCabe, Christopher

    2015-01-01

    We introduce a Minimal Simplified Dark Matter (MSDM) framework to quantitatively characterise dark matter (DM) searches at the LHC. We study two MSDM models where the DM is a Dirac fermion which interacts with a vector and axial-vector mediator. The models are characterised by four parameters: m DM , M med, g DM and g q , the DM and mediator masses, and the mediator couplings to DM and quarks respectively. The MSDM models accurately capture the full event kinematics, and the dependence on all masses and couplings can be systematically studied. The interpretation of mono-jet searches in this framework can be used to establish an equal-footing comparison with direct detection experiments. For theories with a vector mediator, LHC mono-jet searches possess better sensitivity than direct detection searches for light DM masses (≲5 GeV). For axial-vector mediators, LHC and direct detection searches generally probe orthogonal directions in the parameter space. We explore the projected limits of these searches from the ultimate reach of the LHC and multi-ton xenon direct detection experiments, and find that the complementarity of the searches remains. In conclusion, we provide a comparison of limits in the MSDM and effective field theory (EFT) frameworks to highlight the deficiencies of the EFT framework, particularly when exploring the complementarity of mono-jet and direct detection searches

  7. Minimal spin-3/2 dark matter in a simple s-channel model

    Energy Technology Data Exchange (ETDEWEB)

    Khojali, Mohammed Omer; Goyal, Ashok; Kumar, Mukesh; Cornell, Alan S. [University of the Witwatersrand, Wits, National Institute for Theoretical Physics, School of Physics and Mandelstam Institute for Theoretical Physics, Johannesburg (South Africa)

    2017-01-15

    We consider a spin-3/2 fermionic dark matter candidate (DM) interacting with Standard Model fermions through a vector mediator in the s-channel. We find that for pure vector couplings almost the entire parameter space of the DM and mediator mass consistent with the observed relic density is ruled out by the direct detection observations through DM-nucleon elastic scattering cross sections. In contrast, for pure axial-vector coupling, the most stringent constraints are obtained from monojet searches at the Large Hadron Collider. (orig.)

  8. Scalar dark matter in the B−L model

    International Nuclear Information System (INIS)

    Rodejohann, Werner; Yaguna, Carlos E.

    2015-01-01

    The U(1) B−L extension of the Standard Model requires the existence of right-handed neutrinos and naturally realizes the seesaw mechanism of neutrino mass generation. We study the possibility of explaining the dark matter in this model with an additional scalar field, ϕ DM , that is a singlet of the Standard Model but charged under U(1) B−L . An advantage of this scenario is that the stability of ϕ DM can be guaranteed by appropriately choosing its B−L charge, without the need of an extra ad hoc discrete symmetry. We investigate in detail the dark matter phenomenology of this model. We show that the observed dark matter density can be obtained via gauge or scalar interactions, and that semi-annihilations could play an important role in the latter case. The regions consistent with the dark matter density are determined in each instance and the prospects for detection in future experiments are analyzed. If dark matter annihilations are controlled by the B−L gauge interaction, the mass of the dark matter particle should lie below 5 TeV and its direct detection cross section can be easily probed by XENON1T; if instead they are controlled by scalar interactions, the dark matter mass can be much larger and the detection prospects are less certain. Finally, we show that this scenario can be readily extended to accommodate multiple dark matter particles

  9. DM ORI: A YOUNG STAR OCCULTED BY A DISTURBANCE IN ITS PROTOPLANETARY DISK

    Energy Technology Data Exchange (ETDEWEB)

    Rodriguez, Joseph E.; Stassun, Keivan G.; Lund, Michael B.; Weintraub, David A. [Department of Physics and Astronomy, Vanderbilt University, 6301 Stevenson Center, Nashville, TN 37235 (United States); Cargile, Phillip [Harvard-Smithsonian Center for Astrophysics, 60 Garden Street, Cambridge, MA 02138 (United States); Shappee, Benjamin J. [Carnegie Observatories, 813 Santa Barbara Street, Pasadena, CA 91101 (United States); Siverd, Robert J. [Las Cumbres Observatory Global Telescope Network, 6740 Cortona Drive, Suite 102, Santa Barbara, CA 93117 (United States); Pepper, Joshua [Department of Physics, Lehigh University, 16 Memorial Drive East, Bethlehem, PA 18015 (United States); Kochanek, Christopher S.; Gaudi, B. Scott; Stanek, Krzysztof Z.; Holoien, Thomas W.-S. [Department of Astronomy, The Ohio State University, Columbus, OH 43210 (United States); James, David [Cerro Tololo InterAmerican Observatory, Casilla 603, La Serena (Chile); Kuhn, Rudolf B. [South African Astronomical Observatory, P.O. Box 9, Observatory 7935 (South Africa); Beatty, Thomas G. [Department of Astronomy and Astrophysics, The Pennsylvania State University, 525 Davey Lab, University Park, PA 16802 (United States); Prieto, Jose L. [Nucleo de Astronoma de la Facultad de Ingeniera, Universidad Diego Portales, Av. Ejercito 441, Santiago (Chile); Feldman, Daniel M.; Espaillat, Catherine C. [Department of Astronomy, Boston University, 725 Commonwealth Avenue, Boston, MA 02215 (United States)

    2016-11-01

    In some planet formation theories, protoplanets grow gravitationally within a young star’s protoplanetary disk, a signature of which may be a localized disturbance in the disk’s radial and/or vertical structure. Using time-series photometric observations by the Kilodegree Extremely Little Telescope South project and the All-Sky Automated Survey for SuperNovae, combined with archival observations, we present the discovery of two extended dimming events of the young star, DM Ori. This young system faded by ∼1.5 mag from 2000 March to 2002 August and then again in 2013 January until 2014 September (depth ∼1.7 mag). We constrain the duration of the 2000–2002 dimming to be < 860 days, and the event in 2013–2014 to be < 585 days, separated by ∼12.5 years. A model of the spectral energy distribution indicates a large infrared excess consistent with an extensive circumstellar disk. Using basic kinematic arguments, we propose that DM Ori is likely being periodically occulted by a feature (possibly a warp or perturbation) in its circumstellar disk. In this scenario, the occulting feature is located >6 au from the host star, moving at ∼14.6 km s{sup −1} and is ∼4.9 au in width. This localized structure may indicate a disturbance such as that which may be caused by a protoplanet early in its formation.

  10. Data Clustering Menggunakan Metodologi CRISP-DM Untuk Pengenalan Pola Proporsi Pelaksanaan Tridharma

    Directory of Open Access Journals (Sweden)

    Irwan Budiman

    2014-01-01

    Full Text Available Quality of human resources faculty can be reflected from the implementation of productivity and quality Tridharma (education, research, community service  and  supporting  field  activities.  Lecturer  Workload  and Evaluation of  Higher Education  Tridharma  (BKD  and theEPT-PT  aims  to  ensure  the  implementation  of  the  faculty  task  runs  according  to  the  criteria  set  out  in  legislation.  Data  clusteringTridharma  implementation is needed to  get  some  knowledge  of the  pattern of Tridharma  implementation  at  college.  Clustering  as a  data mining  technique  should be  scalable, reliable  and  meet  an  agreed  standard.  CRISP-DM is the standardization of  data mining  is  used  in this study. The results of data clustering found the pattern of proportion of Tridharma  into 3 clusters representing patterns: professionals, managers and teachers.Keywords : Clustering, CRISP-DM, K-Means, Tridharma

  11. A New Approach to the Long-Term Activity Behavior of DM UMa

    Directory of Open Access Journals (Sweden)

    Taş G.

    2012-12-01

    Full Text Available A long-term activity character of DM UMa (K0-1 IV-III, which is one of the most active members of the RS CVn type variables, is examined using the multicolor photometric observations which spread to the time interval between 1980 and 2009. In this work, we present a new approximation for the long-term light and color variation of DM UMa using data obtained by combining our own observations obtained in the Johnson broad-band U,B,V,R filters between the years 1997 and 2008 and data published in literature. Available light and color data were examined for the long-term and seasonal variations using PERIOD04 program. The period analysis of the V-band data reveals the period estimations of 51.2±2.8 years and 15.1±0.7 years superposed on it. The U-B, B-V and V-R colors do not show correlation with the longer period, but they show variations with a period similar to the shorter one, except for B-V color. The amplitude variation also does not exhibit any correlation with the V light and color curves. It is found that the movement of the spot minima phases in years also indicates the migration period of nearly 15 years, similar to the period derived from the analysis of the long-term photometric observations in V-band.

  12. [Functional activity of the modA, gene in Methylobacterium dichloromethanicum DM4].

    Science.gov (United States)

    Firsova, Y E; Trotsenko, Y A

    2014-01-01

    The putative METDI2644 (modA2) gene of Methylobacterium dichloromethanicum DM4, present in the 126-kbp chromosomal fragment associated with dichloromethane (DCM) degradation was investigated. While this gene is presumed to encode the periplasmic substrate-binding subunit of the molybdate ABC transporter, its conceptual translation also exhibits similarity to the proteins containing the ostA conservative domain and responsible for resistance of gram-negative bacteria to organic solvents. Reverse transcription polymerase chain reaction (RT-PCR) revealed the RNA transcripts of this gene in the cells grown on either DCM or methanol. The mobilizable suicide vector pK18mob was used to obtain a knockout mutant with the METDI2644 gene inactivated by insertion of the gentamycin cassette. The mutant pregrown on methanol exhibited lower growth rate on DCM than the wild-type strain DM4. The difference was not alleviated by addition of sodium molybdate. Our results suggest that the METDI2644 gene product plays a role in cell adaptation to DCM degradation.

  13. The nongravitational interactions of dark matter in colliding galaxy clusters.

    Science.gov (United States)

    Harvey, David; Massey, Richard; Kitching, Thomas; Taylor, Andy; Tittley, Eric

    2015-03-27

    Collisions between galaxy clusters provide a test of the nongravitational forces acting on dark matter. Dark matter's lack of deceleration in the "bullet cluster" collision constrained its self-interaction cross section σ(DM)/m dark matter) for long-ranged forces. Using the Chandra and Hubble Space Telescopes, we have now observed 72 collisions, including both major and minor mergers. Combining these measurements statistically, we detect the existence of dark mass at 7.6σ significance. The position of the dark mass has remained closely aligned within 5.8 ± 8.2 kiloparsecs of associated stars, implying a self-interaction cross section σ(DM)/m < 0.47 cm(2)/g (95% CL) and disfavoring some proposed extensions to the standard model. Copyright © 2015, American Association for the Advancement of Science.

  14. Disrupted subject-specific gray matter network properties and cognitive dysfunction in type 1 diabetes patients with and without proliferative retinopathy

    NARCIS (Netherlands)

    van Duinkerken, Eelco; Ijzerman, Richard G.; Klein, Martin; Moll, Annette C.; Snoek, Frank J.; Scheltens, Philip; Pouwels, Petra J. W.; Barkhof, Frederik; Diamant, Michaela; Tijms, Betty M.

    2016-01-01

    Type 1 diabetes mellitus (T1DM) patients, especially with concomitant microvascular disease, such as proliferative retinopathy, have an increased risk of cognitive deficits. Local cortical gray matter volume reductions only partially explain these cognitive dysfunctions, possibly because volume

  15. White dwarf stars: cosmic chronometers and dark matter probes

    Science.gov (United States)

    Salaris, Maurizio; Cassisi, Santi

    2018-04-01

    White dwarfs (WD) are the endpoint of the evolution of the large majority of stars formed in our galaxy. In the last two decades observations and theory have improved to a level that makes it possible to employ WD for determining ages of the stellar populations in the disk of the Milky Way and in the nearest star clusters, and constrain the existence and properties of dark matter (DM) candidates. This review is centred on WD models, age-dating, and DM identification methods, recent results and future developments of the field.

  16. Quantum treatment of neutrino in background matter

    International Nuclear Information System (INIS)

    Studenikin, A I

    2006-01-01

    Motivated by the need of elaboration of the quantum theory of the spin light of neutrino in matter (SLν), we have studied in more detail the exact solutions of the Dirac equation for neutrinos moving in background matter. These exact neutrino wavefunctions form a basis for a rather powerful method of investigation of different neutrino processes in matter, which is similar to the Furry representation of quantum electrodynamics in external fields. Within this method we also derive the corresponding Dirac equation for an electron moving in matter and consider the electromagnetic radiation ('spin light of electron in matter' (SLe)) that can be emitted by the electron in this case

  17. Dry matter content and fruit size affect flavour and texture of novel Actinidia deliciosa genotypes.

    Science.gov (United States)

    Nardozza, Simona; Gamble, Joanna; Axten, Lauren G; Wohlers, Mark W; Clearwater, Michael J; Feng, Jinquan; Harker, F Roger

    2011-03-15

    Previous studies with commercial kiwifruit cultivars have demonstrated that the taste of fruit with higher dry matter content (DM) is more liked by consumers. A unique replicated trial of kiwifruit genotypes (10 high/low DM × small/large-fruited genotypes) has provided an opportunity to consider how the genetic propensity for a kiwifruit to accumulate DM affects fruit flavour and texture. In the present study, eating-ripe fruit from each of the genotypes were assessed using a trained sensory panel and the relationships between these sensory attributes and fresh weight, DM, flesh firmness and soluble solids content (SSC) were explored. The genotypes provided a diversity of flavour and texture attributes, each of which varied in perceived intensity of the sensory experience. High-DM genotypes had higher SSC and were perceived as sweeter than low-DM genotypes. Sweet taste was closely associated with the perception of the tropical flavour and high-DM genotypes were found to have more tropical notes. Fruit size was associated with fruit texture, and small fruit were characterised by a firmer and more fibrous core. Large high-DM fruit were perceived as juicier than those of all other genotypes. Genotypes were perceived differently from one another, and differences in fruit size and DM content were reflected in fruit sensorial properties. This study is unique in demonstrating interactions between fruit size, DM and sensory properties. These findings could be relevant not only to kiwifruit but to fruiting crop breeders in general, because of the demonstrated potential for effects of fruit size and DM content on sweetness, flavour and fruit texture. Copyright © 2010 Society of Chemical Industry.

  18. On the Sunyaev-Zel'dovich effect from dark matter annihilation or decay in galaxy clusters

    International Nuclear Information System (INIS)

    Lavalle, Julien; Boehm, Céline; Barthès, Julien

    2010-01-01

    We revisit the prospects for detecting the Sunyaev Zel'dovich (SZ) effect induced by dark matter (DM) annihilation or decay. We show that with standard (or even extreme) assumptions for DM properties, the optical depth associated with relativistic electrons injected from DM annihilation or decay is much smaller than that associated with thermal electrons, when averaged over the angular resolution of current and future experiments. For example, we find: τ DM ∼ 10 −9 −10 −5 (depending on the assumptions) for m χ = 1 GeV and a density profile ρ∝r −1 for a template cluster located at 50 Mpc and observed within an angular resolution of 10'', compared to τ th ∼ 10 −3 −10 −2 . This, together with a full spectral analysis, enables us to demonstrate that, for a template cluster with generic properties, the SZ effect due to DM annihilation or decay is far below the sensitivity of the Planck satellite. This is at variance with previous claims regarding heavier annihilating DM particles. Should DM be made of lighter particles, the current constraints from 511 keV observations on the annihilation cross section or decay rate still prevent a detectable SZ effect. Finally, we show that spatial diffusion sets a core of a few kpc in the electron distribution, even for very cuspy DM profiles, such that improving the angular resolution of the instrument, eg with ALMA, does not necessarily improve the detection potential. We provide useful analytical formulæ parameterized in terms of the DM mass, decay rate or annihilation cross section and DM halo features, that allow quick estimates of the SZ effect induced by any given candidate and any DM halo profile

  19. Constraints on the dark matter annihilation from Fermi-LAT observation of M31

    Energy Technology Data Exchange (ETDEWEB)

    Li, Zhengwei; Yuan, Qiang [Key Laboratory of Dark Matter and Space Astronomy, Purple Mountain Observatory, Chinese Academy of Sciences, 2 West Beijing Road, Nanjing, 210008 (China); Huang, Xiaoyuan [Physik-Department T30d, Technische Universität München, James-Franck-Straße, Garching, D-85748 Germany (Germany); Xu, Yupeng, E-mail: lizw@ihep.ac.cn, E-mail: huangxiaoyuan@gmail.com, E-mail: yuanq@pmo.ac.cn, E-mail: xuyp@ihep.ac.cn [Key Laboratory of Particle Astrophysics, Institute of High Energy Physics, Chinese Academy of Sciences, 19B Yuquan Road, Beijing, 100049 (China)

    2016-12-01

    Gamma-ray is a good probe of dark matter (DM) particles in the Universe. We search for the DM annihilation signals in the direction of the Andromeda galaxy (M31) using 7.5 year Fermi-LAT pass 8 data. Similar to Pshirkov et al. (2016), we find that there is residual excess emission from the direction of M31 if only the galactic disk as traced by the far infrared emission is considered. Adding a point-like source will improve the fitting effectively, although additional slight improvements can be found if an extended component such as a uniform disk or two bubbles is added instead. Taking the far infrared disk plus a point source as the background model, we search for the DM annihilation signals in the data. We find that there is strong degeneracy between the emission from the galaxy and that from 10s GeV mass DM annihilation in the main halo with quark final state. However, the required DM annihilation cross section is about 10{sup −25}–10{sup −24} cm{sup 3}s{sup −1}, orders of magnitude larger than the constraints from observations of dwarf spheroidal galaxies, indicating a non-DM origin of the emission. If DM subhalos are taken into account, the degeneracy is broken. When considering the enhancement from DM subhalos, the constraints on DM model parameters are comparable to (or slightly weaker than) those from the population of dwarf spheroidal galaxies. We also discuss the inverse Compton scattering component from DM annihilation induced electrons/positrons. For the first time we include an energy dependent template of the inverse Compton emission (i.e., a template cube) in the data analysis to take into account the effect of diffusion of charged particles. We find a significant improvement of the constraints in the high mass range of DM particles after considering the inverse Compton emission.

  20. Baryonic pinching of galactic dark matter halos

    International Nuclear Information System (INIS)

    Gustafsson, Michael; Fairbairn, Malcolm; Sommer-Larsen, Jesper

    2006-01-01

    High resolution cosmological N-body simulations of four galaxy-scale dark matter halos are compared to corresponding N-body/hydrodynamical simulations containing dark matter, stars and gas. The simulations without baryons share features with others described in the literature in that the dark matter density slope continuously decreases towards the center, with a density ρ DM ∝r -1.3±0.2 , at about 1% of the virial radius for our Milky Way sized galaxies. The central cusps in the simulations which also contain baryons steepen significantly, to ρ DM ∝r -1.9±0.2 , with an indication of the inner logarithmic slope converging. Models of adiabatic contraction of dark matter halos due to the central buildup of stellar/gaseous galaxies are examined. The simplest and most commonly used model, by Blumenthal et al., is shown to overestimate the central dark matter density considerably. A modified model proposed by Gnedin et al. is tested and it is shown that, while it is a considerable improvement, it is not perfect. Moreover, it is found that the contraction parameters in their model not only depend on the orbital structure of the dark-matter-only halos but also on the stellar feedback prescription which is most relevant for the baryonic distribution. Implications for dark matter annihilation at the galactic center are discussed and it is found that, although our simulations show a considerable reduced dark matter halo contraction as compared to the Blumenthal et al. model, the fluxes from dark matter annihilation are still expected to be enhanced by at least a factor of a hundred, as compared to dark-matter-only halos. Finally, it is shown that, while dark-matter-only halos are typically prolate, the dark matter halos containing baryons are mildly oblate with minor-to-major axis ratios of c/a=0.73±0.11, with their flattening aligned with the central baryonic disks

  1. The interaction of the antitoxin DM43 with a snake venom metalloproteinase analyzed by mass spectrometry and surface plasmon resonance

    DEFF Research Database (Denmark)

    Brand, Guilherme D; Salbo, Rune; Jørgensen, Thomas J D

    2012-01-01

    DM43 is a circulating dimeric antitoxin isolated from Didelphis aurita, a South American marsupial naturally immune to snake envenomation. This endogenous inhibitor binds non-covalently to jararhagin, the main hemorrhagic metalloproteinase from Bothrops jararaca snake venom, and efficiently...

  2. Biohydrogen production from desugared molasses (DM) using thermophilic mixed cultures immobilized on heat treated anaerobic sludge granules

    DEFF Research Database (Denmark)

    Kongjan, Prawit; O-Thong, Sompong; Angelidaki, Irini

    2011-01-01

    Hydrogen production from desugared molasses (DM) was investigated in both batch and continuous reactors using thermophilic mixed cultures enriched from digested manure by load shock (loading with DM concentration of 50.1 g-sugar/L) to suppress methanogens. H2 gas, free of methane, was produced......) and Thermoanaerobacterium thermosaccharolyticum with a relative abundance of 36%, 27%, and 10% of total microorganisms, respectively. This study shows that hydrogen production could be efficiently facilitated by using anaerobic granules as a carrier, where microbes from mixed culture enriched in the DM batch cultivation....... The enriched hydrogen producing mixed culture achieved from the 16.7 g-sugars/L DM batch cultivation was immobilized on heat treated anaerobic sludge granules in an up-flow anaerobic sludge blanket (UASB) reactor. The UASB reactor, operated at a hydraulic retention time (HRT) of 24 h fed with 16.7 g...

  3. Single Crystal Piezoelectric Stack Actuator DM with Integrated Low-Power HVA-Based Driver ASIC, Phase I

    Data.gov (United States)

    National Aeronautics and Space Administration — This SBIR Phase I project aims to develop an innovative batch fabrication technique to create single crystal PMN-PT stack actuator deformable mirrors (DM) at low...

  4. Dry matter losses of grass, lucerne and maize silages in bunker silos

    Directory of Open Access Journals (Sweden)

    Brigitte Koehler

    2013-03-01

    Full Text Available An efficient feed management is important for a sustainable and economic agricultural production. One of the main points for improving the efficiency is the reduction of feed losses. In the present investigation the dry matter (DM losses of grass, lucerne and maize silages in farm scaled bunker silos were analysed. The method of determining DM losses was the total-in versus total-out DM mass flow of the silos, including the determination of DM content and other silage parameters via manual sampling. The results taken from 48 silos showed on average for all investigated crops 9–12% of DM losses. Density and feed out rate showed a negative correlation to DM losses in maize silages. According to the applied method for determining DM losses on farm scale, a guideline of 8% can be suggested for maximum DM losses in bunker silos for grass and maize silages. The described method seems to be applicable for improving the feed management by using largely automated measurements on the harvest and feeding side.

  5. Dark Matter Search in a Beam-Dump eXperiment (BDX) at Jefferson Lab

    International Nuclear Information System (INIS)

    Battaglieri, M.

    2016-01-01

    MeV-GeV dark matter (DM) is theoretically well motivated but remarkably unexplored. This proposal presents the MeV-GeV DM discovery potential for a ∼ 1 m$^3$ segmented CsI(Tl) scintillator detector placed downstream of the Hall A beam-dump at Jefferson Lab, receiving up to 10 22 electrons-on-target (EOT) in 285 days. This experiment (Beam-Dump eXperiment or BDX) would be sensitive to elastic DM-electron and to inelastic DM scattering at the level of 10 counts per year, reaching the limit of the neutrino irreducible background. The distinct signature of a DM interaction will be an electromagnetic shower of few hundreds of MeV, together with a reduced activity in the surrounding active veto counters. A detailed description of the DM particle χ production in the dump and subsequent interaction in the detector has been performed by means of Monte Carlo simulations. Different approaches have been used to evaluate the expected backgrounds: the cosmogenic background has been extrapolated from the results obtained with a prototype detector running at INFN-LNS (Italy), while the beam-related background has been evaluated by GEANT4 Monte Carlo simulations. The proposed experiment will be sensitive to large regions of DM parameter space, exceeding the discovery potential of existing and planned experiments in the MeV-GeV DM mass range by up to two orders of magnitude.

  6. Electrophilic dark matter with dark photon: From DAMPE to direct detection

    Science.gov (United States)

    Gu, Pei-Hong; He, Xiao-Gang

    2018-03-01

    The electron-positron excess reported by the DAMPE collaboration recently may be explained by an electrophilic dark matter (DM). A standard model singlet fermion may play the role of such a DM when it is stabilized by some symmetries, such as a dark U(1)X gauge symmetry, and dominantly annihilates into the electron-positron pairs through the exchange of a scalar mediator. The model, with appropriate Yukawa couplings, can well interpret the DAMPE excess. Naively one expects that in this type of models the DM-nucleon cross section should be small since there is no tree-level DM-quark interactions. We however find that at one-loop level, a testable DM-nucleon cross section can be induced for providing ways to test the electrophilic model. We also find that a U (1) kinetic mixing can generate a sizable DM-nucleon cross section although the U(1)X dark photon only has a negligible contribution to the DM annihilation. Depending on the signs of the mixing parameter, the dark photon can enhance/reduce the one-loop induced DM-nucleon cross section.

  7. Dark Matter Search in a Beam-Dump eXperiment (BDX) at Jefferson Lab

    Energy Technology Data Exchange (ETDEWEB)

    Battaglieri, M. [Univ. of Genova (Italy). National Institute for Nuclear Physics. et al

    2016-07-05

    MeV-GeV dark matter (DM) is theoretically well motivated but remarkably unexplored. This proposal presents the MeV-GeV DM discovery potential for a $\\sim$1 m$^3$ segmented CsI(Tl) scintillator detector placed downstream of the Hall A beam-dump at Jefferson Lab, receiving up to 10$^{22}$ electrons-on-target (EOT) in 285 days. This experiment (Beam-Dump eXperiment or BDX) would be sensitive to elastic DM-electron and to inelastic DM scattering at the level of 10 counts per year, reaching the limit of the neutrino irreducible background. The distinct signature of a DM interaction will be an electromagnetic shower of few hundreds of MeV, together with a reduced activity in the surrounding active veto counters. A detailed description of the DM particle $\\chi$ production in the dump and subsequent interaction in the detector has been performed by means of Monte Carlo simulations. Different approaches have been used to evaluate the expected backgrounds: the cosmogenic background has been extrapolated from the results obtained with a prototype detector running at INFN-LNS (Italy), while the beam-related background has been evaluated by GEANT4 Monte Carlo simulations. The proposed experiment will be sensitive to large regions of DM parameter space, exceeding the discovery potential of existing and planned experiments in the MeV-GeV DM mass range by up to two orders of magnitude.

  8. Dynamical basis set

    International Nuclear Information System (INIS)

    Blanco, M.; Heller, E.J.

    1985-01-01

    A new Cartesian basis set is defined that is suitable for the representation of molecular vibration-rotation bound states. The Cartesian basis functions are superpositions of semiclassical states generated through the use of classical trajectories that conform to the intrinsic dynamics of the molecule. Although semiclassical input is employed, the method becomes ab initio through the standard matrix diagonalization variational method. Special attention is given to classical-quantum correspondences for angular momentum. In particular, it is shown that the use of semiclassical information preferentially leads to angular momentum eigenstates with magnetic quantum number Vertical BarMVertical Bar equal to the total angular momentum J. The present method offers a reliable technique for representing highly excited vibrational-rotational states where perturbation techniques are no longer applicable

  9. Design basis 2

    Energy Technology Data Exchange (ETDEWEB)

    Larsen, G.; Soerensen, P. [Risoe National Lab., Roskilde (Denmark)

    1996-09-01

    Design Basis Program 2 (DBP2) is comprehensive fully coupled code which has the capability to operate in the time domain as well as in the frequency domain. The code was developed during the period 1991-93 and succeed Design Basis 1, which is a one-blade model presuming stiff tower, transmission system and hub. The package is designed for use on a personal computer and offers a user-friendly environment based on menu-driven editing and control facilities, and with graphics used extensively for the data presentation. Moreover in-data as well as results are dumped on files in Ascii-format. The input data is organized in a in-data base with a structure that easily allows for arbitrary combinations of defined structural components and load cases. (au)

  10. Downregulation of DmMANF in Glial Cells Results in Neurodegeneration and Affects Sleep and Lifespan in Drosophila melanogaster

    Directory of Open Access Journals (Sweden)

    Lucyna Walkowicz

    2017-11-01

    Full Text Available In Drosophila melanogaster, mesencephalic astrocyte-derived neurotrophic factor (DmMANF is an evolutionarily conserved ortholog of mammalian MANF and cerebral dopamine neurotrophic factor (CDNF, which have been shown to promote the survival of dopaminergic neurons in the brain. We observed especially high levels of DmMANF in the visual system of Drosophila, particularly in the first optic neuropil (lamina. In the lamina, DmMANF was found in glial cells (surface and epithelial glia, photoreceptors and interneurons. Interestingly, silencing of DmMANF in all neurons or specifically in photoreceptors or L2 interneurons had no impact on the structure of the visual system. However, downregulation of DmMANF in glial cells induced degeneration of the lamina. Remarkably, this degeneration in the form of holes and/or tightly packed membranes was observed only in the lamina epithelial glial cells. Those membranes seem to originate from the endoplasmic reticulum, which forms autophagosome membranes. Moreover, capitate projections, the epithelial glia invaginations into photoreceptor terminals that are involved in recycling of the photoreceptor neurotransmitter histamine, were less numerous after DmMANF silencing either in neurons or glial cells. The distribution of the alpha subunit of Na+/K+-ATPase protein in the lamina cell membranes was also changed. At the behavioral level, silencing of DmMANF either in neurons or glial cells affected the daily activity/sleep pattern, and flies showed less activity during the day but higher activity during the night than did controls. In the case of silencing in glia, the lifespan of flies was also shortened. The obtained results showed that DmMANF regulates many functions in the brain, particularly those dependent on glial cells.

  11. Do Adolescents with T1DM Differ from Their Peers in Health, Eating Habits and Social Support?

    Science.gov (United States)

    Husárová, Daniela; Kostičová, Michaela; Kočišová, Denisa; Schusterová, Ingrid; Gecková, Andrea Madarasová

    2017-12-01

    The aim of this study was to analyse differences in health, eating habits and social support in adolescents with type 1 diabetes mellitus (T1DM) in comparison to peers with another long-term illness or without any medical condition. We used self-reported data from the cross-sectional Health Behaviour in School-aged Children study collected in 2014 among Slovak adolescents as well as data from adolescents with T1DM collected in outpatient settings (11 to 15 years old, N=8,910, 50.3% of boys). Logistic regression models and general linear models were used to analyse differences between adolescents with T1DM and their peers with and without long-term illness in self-rated health, life satisfaction, health complaints, regular breakfast, sweets and soft drink consumption, and perceived support from family, teachers and classmates. Adolescents with T1DM reported worse self-rated health and suffer from more health complaints, but they have lower chance of having breakfast irregularly in comparison to their peers with another long-term illness or without any medical condition. Moreover, compared with their peers, adolescents with T1DM perceived stronger support from teachers and classmates, but weaker support from their family. We did not confirm any differences in life satisfaction, sweets and soft drink consumption between adolescents with T1DM and their peers. Adolescents with T1DM reported more regular eating habits, no difference in life satisfaction and more social support outside the family in comparison to their peers. However, their worse self-rated health, more health complaints and weaker support from family should be considered in interventions targeting psychosocial adjustment of adolescents with T1DM. Copyright© by the National Institute of Public Health, Prague 2017

  12. "I Know that You Know that I Know": Neural Substrates Associated with Social Cognition Deficits in DM1 Patients.

    Directory of Open Access Journals (Sweden)

    Laura Serra

    Full Text Available Myotonic dystrophy type-1 (DM1 is a genetic multi-systemic disorder involving several organs including the brain. Despite the heterogeneity of this condition, some patients with non-congenital DM1 can present with minimal cognitive impairment on formal testing but with severe difficulties in daily-living activities including social interactions. One explanation for this paradoxical mismatch can be found in patients' dysfunctional social cognition, which can be assessed in the framework of the Theory of Mind (ToM. We hypothesize here that specific disease driven abnormalities in DM1 brains may result in ToM impairments. We recruited 20 DM1 patients who underwent the "Reading the Mind in the Eyes" and the ToM-story tests. These patients, together with 18 healthy controls, also underwent resting-state functional MRI. A composite Theory of Mind score was computed for all recruited patients and correlated with their brain functional connectivity. This analysis provided the patients' "Theory of Mind-network", which was compared, for its topological properties, with that of healthy controls. We found that DM1 patients showed deficits in both tests assessing ToM. These deficits were associated with specific patterns of abnormal connectivity between the left inferior temporal and fronto-cerebellar nodes in DM1 brains. The results confirm the previous suggestions of ToM dysfunctions in patients with DM1 and support the hypothesis that difficulties in social interactions and personal relationships are a direct consequence of brain abnormalities, and not a reaction symptom. This is relevant not only for a better pathophysiological comprehension of DM1, but also for non-pharmacological interventions to improve clinical aspects and impact on patients' success in life.

  13. Dark matter relic abundance and light sterile neutrinos

    Energy Technology Data Exchange (ETDEWEB)

    Tang, Yi-Lei [Center for High Energy Physics,Peking University, Beijing 100871 (China); Zhu, Shou-hua [Center for High Energy Physics,Peking University, Beijing 100871 (China); Institute of Theoretical Physics & State Key Laboratory of Nuclear Physics and Technology,Peking University, Beijing 100871 (China); Collaborative Innovation Center of Quantum Matter,Beijing 100871 (China)

    2017-01-09

    In this paper, we calculate the relic abundance of the dark matter particles when they can annihilate into sterile neutrinos with the mass ≲100 GeV in a simple model. Unlike the usual standard calculations, the sterile neutrino may fall out of the thermal equilibrium with the thermal bath before the dark matter freezes out. In such a case, if the Yukawa coupling y{sub N} between the Higgs and the sterile neutrino is small, this process gives rise to a larger Ω{sub DM}h{sup 2} so we need a larger coupling between the dark matter and the sterile neutrino for a correct relic abundance.

  14. Cold light dark matter in extended seesaw models

    Science.gov (United States)

    Boulebnane, Sami; Heeck, Julian; Nguyen, Anne; Teresi, Daniele

    2018-04-01

    We present a thorough discussion of light dark matter produced via freeze-in in two-body decays A→ B DM . If A and B are quasi-degenerate, the dark matter particle has a cold spectrum even for keV masses. We show this explicitly by calculating the transfer function that encodes the impact on structure formation. As examples for this setup we study extended seesaw mechanisms with a spontaneously broken global U(1) symmetry, such as the inverse seesaw. The keV-scale pseudo-Goldstone dark matter particle is then naturally produced cold by the decays of the quasi-degenerate right-handed neutrinos.

  15. A fresh look into the interacting dark matter scenario

    Science.gov (United States)

    Escudero, Miguel; Lopez-Honorez, Laura; Mena, Olga; Palomares-Ruiz, Sergio; Villanueva-Domingo, Pablo

    2018-06-01

    The elastic scattering between dark matter particles and radiation represents an attractive possibility to solve a number of discrepancies between observations and standard cold dark matter predictions, as the induced collisional damping would imply a suppression of small-scale structures. We consider this scenario and confront it with measurements of the ionization history of the Universe at several redshifts and with recent estimates of the counts of Milky Way satellite galaxies. We derive a conservative upper bound on the dark matter-photon elastic scattering cross section of σγ DM non-cold dark matter candidates, such as interacting and warm dark matter scenarios. Let us emphasize that bounds of similar magnitude to the ones obtained here could be also derived for models with dark matter-neutrino interactions and would be as constraining as the tightest limits on such scenarios.

  16. The Flavour Portal to Dark Matter

    CERN Document Server

    Calibbi, Lorenzo; Zaldivar, Bryan

    2015-01-01

    We present a class of models in which dark matter (DM) is a fermionic singlet under the Standard Model (SM) gauge group but is charged under a symmetry of flavour that acts as well on the SM fermions. Interactions between DM and SM particles are mediated by the scalar fields that spontaneously break the flavour symmetry, the so-called flavons. In the case of gauged flavour symmetries, the interactions are also mediated by the flavour gauge bosons. We first discuss the construction and the generic features of this class of models. Then a concrete example with an abelian flavour symmetry is considered. We compute the complementary constraints from the relic abundance, direct detection experiments and flavour observables, showing that wide portions of the parameter space are still viable. Other possibilities like non-abelian flavour symmetries can be analysed within the same framework.

  17. Characterization of a noncytotoxic bacteriocin from probiotic Lactobacillus plantarum DM5 with potential as a food preservative.

    Science.gov (United States)

    Das, Deeplina; Goyal, Arun

    2014-10-01

    The aim of this work was to purify and characterize the bacteriocin produced by probiotic Lactobacillus plantarum DM5 in order to evaluate its potential as nutraceuticals. Lb. plantarum DM5 exhibited in vitro probiotic properties such as high resistance to gastric juice and bile salt, adherence to human adenocarcinoma (HT-29) cells, bile salt hydrolase and cholesterol assimilation activity. Moreover, Lb. plantarum DM5 showed bacteriocin activity against several major food borne pathogens. Zymogram analysis of purified bacteriocin (plantaricin DM5) showed a molecular size of ∼15.2 kDa. Plantaricin DM5 was sensitive to proteolytic enzymes but stable in the pH range of 2.0-10.0, and it was heat resistant (121 °C for 15 min) and remained active upon treatment with surfactants and detergents. Cytotoxicity analysis of plantaricin DM5 on human embryonic kidney 293 (HEK 293) and human cervical cancer (HeLa) cell lines revealed its nontoxic and biocompatible nature. To the best of our knowledge, this is the first study on the isolated strain expressing probiotic properties and broad antimicrobial activity without any cytotoxic effect on mammalian cells from indigenous fermented beverage Marcha from India, and thus contributes to the food industry as a novel bio-preservant.

  18. Inhibition of HLA-DM mediated MHC class II peptide loading by HLA-DO promotes self tolerance

    Directory of Open Access Journals (Sweden)

    Lisa K. Denzin

    2013-12-01

    Full Text Available Major histocompatibility class II (MHCII molecules are loaded with peptides derived from foreign and self-proteins within the endosomes and lysosomes of antigen presenting cells (APCs. This process is mediated by interaction of MHCII with the conserved, nonpolymorphic MHCII-like molecule HLA-DM (DM. DM activity is directly opposed by HLA-DO (DO, another conserved, non-polymorphic MHCII like molecule. DO is an MHCII substrate mimic. Binding of DO to DM prevents MHCII from binding to DM, thereby inhibiting peptide loading. Inhibition of DM function enables low stability MHC complexes to survive and populate the surface of APCS. As a consequence, DO promotes the display of a broader pool of low abundance self-peptides. Broadening the peptide repertoire theoretically reduces the likelihood of inadvertently acquiring a density of self-ligands that is sufficient to activate self-reactive T cells. One function of DO, therefore, is to promote T cell tolerance by shaping the visible image of self. Recent data also shows that DO influences the adaptive immune response by controlling B cell entry into the germinal center reaction. This review explores the data supporting these concepts.

  19. The case for mixed dark matter from sterile neutrinos

    International Nuclear Information System (INIS)

    Lello, Louis; Boyanovsky, Daniel

    2016-01-01

    Sterile neutrinos are SU(2) singlets that mix with active neutrinos via a mass matrix, its diagonalization leads to mass eigenstates that couple via standard model vertices. We study the cosmological production of heavy neutrinos via standard model charged and neutral current vertices under a minimal set of assumptions: i) the mass basis contains a hierarchy of heavy neutrinos , ii) these have very small mixing angles with the active (flavor) neutrinos, iii) standard model particles, including light (active-like) neutrinos are in thermal equilibrium. If kinematically allowed, the same weak interaction processes that produce active-like neutrinos also produce the heavier species. We introduce the quantum kinetic equations that describe their production, freeze out and decay and discuss the various processes that lead to their production in a wide range of temperatures assessing their feasibility as dark matter candidates. The final distribution function at freeze-out is a mixture of the result of the various production processes. We identify processes in which finite temperature collective excitations may lead to the production of the heavy species. As a specific example, we consider the production of heavy neutrinos in the mass range M h ∼< 140 MeV from pion decay shortly after the QCD crossover including finite temperature corrections to the pion form factors and mass. We consider the different decay channels that allow for the production of heavy neutrinos showing that their frozen distribution functions exhibit effects from ''kinematic entanglement'' and argue for their viability as mixed dark matter candidates. We discuss abundance, phase space density and stability constraints and argue that heavy neutrinos with lifetime τ> 1/ H 0 freeze out of local thermal equilibrium, and conjecture that those with lifetimes τ || 1/ H 0 may undergo cascade decay into lighter DM candidates and/or inject non-LTE neutrinos into the cosmic neutrino

  20. The case for mixed dark matter from sterile neutrinos

    Energy Technology Data Exchange (ETDEWEB)

    Lello, Louis; Boyanovsky, Daniel, E-mail: lal81@pitt.edu, E-mail: boyan@pitt.edu [Department of Physics and Astronomy, University of Pittsburgh, Pittsburgh, PA 15260 (United States)

    2016-06-01

    Sterile neutrinos are SU(2) singlets that mix with active neutrinos via a mass matrix, its diagonalization leads to mass eigenstates that couple via standard model vertices. We study the cosmological production of heavy neutrinos via standard model charged and neutral current vertices under a minimal set of assumptions: i) the mass basis contains a hierarchy of heavy neutrinos , ii) these have very small mixing angles with the active (flavor) neutrinos, iii) standard model particles, including light (active-like) neutrinos are in thermal equilibrium. If kinematically allowed, the same weak interaction processes that produce active-like neutrinos also produce the heavier species. We introduce the quantum kinetic equations that describe their production, freeze out and decay and discuss the various processes that lead to their production in a wide range of temperatures assessing their feasibility as dark matter candidates. The final distribution function at freeze-out is a mixture of the result of the various production processes. We identify processes in which finite temperature collective excitations may lead to the production of the heavy species. As a specific example, we consider the production of heavy neutrinos in the mass range M {sub h} ∼< 140 MeV from pion decay shortly after the QCD crossover including finite temperature corrections to the pion form factors and mass. We consider the different decay channels that allow for the production of heavy neutrinos showing that their frozen distribution functions exhibit effects from ''kinematic entanglement'' and argue for their viability as mixed dark matter candidates. We discuss abundance, phase space density and stability constraints and argue that heavy neutrinos with lifetime τ> 1/ H {sub 0} freeze out of local thermal equilibrium, and conjecture that those with lifetimes τ || 1/ H {sub 0} may undergo cascade decay into lighter DM candidates and/or inject non-LTE neutrinos into the

  1. On the interpretation of dark matter self-interactions in Abell 3827

    International Nuclear Information System (INIS)

    Kahlhoefer, Felix; Schmidt-Hoberg, Kai; Kummer, Janis; Sarkar, Subir

    2015-04-01

    Self-interactions of dark matter particles can potentially lead to an observable separation between the dark matter halo and the stars of a galaxy moving through a region of large dark matter density. Such a separation has recently been observed in a galaxy falling into the core of the galaxy cluster Abell 3827. We estimated the DM self-interaction cross section needed to reproduce the observed effects and find that the sensitivity of Abell 3827 has been significantly overestimated in a previous study. Our corrected estimate is σ/m DM ∝3 cm 2 g -1 when self-interactions result in an effective drag force and σ/m DM ∝ 1.5 cm 2 g -1 for the case of contact interactions, in some tension with previous upper bounds.

  2. Halo-independent direct detection of momentum-dependent dark matter

    Energy Technology Data Exchange (ETDEWEB)

    Cherry, John F. [Theoretical Division, Los Alamos National Laboratory, Los Alamos, New Mexico 87545 (United States); Frandsen, Mads T.; Shoemaker, Ian M., E-mail: jcherry@lanl.gov, E-mail: frandsen@cp3-origins.net, E-mail: shoemaker@cp3-origins.net [CP3-Origins and the Danish Institute for Advanced Study, University of Southern Denmark, Campusvej 55, DK-5230 Odense M (Denmark)

    2014-10-01

    We show that the momentum dependence of dark matter interactions with nuclei can be probed in direct detection experiments without knowledge of the dark matter velocity distribution. This is one of the few properties of DM microphysics that can be determined with direct detection alone, given a signal of dark matter in multiple direct detection experiments with different targets. Long-range interactions arising from the exchange of a light mediator are one example of momentum-dependent DM. For data produced from the exchange of a massless mediator we find for example that the mediator mass can be constrained to be ∼< 10 MeV for DM in the 20-1000 GeV range in a halo-independent manner.

  3. Halo-independent direct detection of momentum-dependent dark matter

    International Nuclear Information System (INIS)

    Cherry, John F.; Frandsen, Mads T.; Shoemaker, Ian M.

    2014-01-01

    We show that the momentum dependence of dark matter interactions with nuclei can be probed in direct detection experiments without knowledge of the dark matter velocity distribution. This is one of the few properties of DM microphysics that can be determined with direct detection alone, given a signal of dark matter in multiple direct detection experiments with different targets. Long-range interactions arising from the exchange of a light mediator are one example of momentum-dependent DM. For data produced from the exchange of a massless mediator we find for example that the mediator mass can be constrained to be ∼< 10 MeV for DM in the 20-1000 GeV range in a halo-independent manner

  4. Prevalence of diabetic retinopathy and its relationship with glomerular filtration rate and other risk factors in patients with type 2 diabetes mellitus in Spain. DM2 HOPE study

    Directory of Open Access Journals (Sweden)

    Maribel López

    2017-09-01

    Conclusion: Around one in seven patients with T2DM has DR after nine years since diagnosis. Time since diagnosis, insulin therapy, cardiovascular profile, and renal dysfunction are associated with DR in patients with T2DM in Spain.

  5. DaMaSCUS: the impact of underground scatterings on direct detection of light dark matter

    Energy Technology Data Exchange (ETDEWEB)

    Emken, Timon; Kouvaris, Chris, E-mail: emken@cp3.sdu.dk, E-mail: kouvaris@cp3.sdu.dk [CP3-Origins, University of Southern Denmark, Campusvej 55, DK-5230 Odense (Denmark)

    2017-10-01

    Conventional dark matter direct detection experiments set stringent constraints on dark matter by looking for elastic scattering events between dark matter particles and nuclei in underground detectors. However these constraints weaken significantly in the sub-GeV mass region, simply because light dark matter does not have enough energy to trigger detectors regardless of the dark matter-nucleon scattering cross section. Even if future experiments lower their energy thresholds, they will still be blind to parameter space where dark matter particles interact with nuclei strongly enough that they lose enough energy and become unable to cause a signal above the experimental threshold by the time they reach the underground detector. Therefore in case dark matter is in the sub-GeV region and strongly interacting, possible underground scatterings of dark matter with terrestrial nuclei must be taken into account because they affect significantly the recoil spectra and event rates, regardless of whether the experiment probes DM via DM-nucleus or DM-electron interaction. To quantify this effect we present the publicly available Dark Matter Simulation Code for Underground Scatterings (DaMaSCUS), a Monte Carlo simulator of DM trajectories through the Earth taking underground scatterings into account. Our simulation allows the precise calculation of the density and velocity distribution of dark matter at any detector of given depth and location on Earth. The simulation can also provide the accurate recoil spectrum in underground detectors as well as the phase and amplitude of the diurnal modulation caused by this shadowing effect of the Earth, ultimately relating the modulations expected in different detectors, which is important to decisively conclude if a diurnal modulation is due to dark matter or an irrelevant background.

  6. DaMaSCUS: the impact of underground scatterings on direct detection of light dark matter

    International Nuclear Information System (INIS)

    Emken, Timon; Kouvaris, Chris

    2017-01-01

    Conventional dark matter direct detection experiments set stringent constraints on dark matter by looking for elastic scattering events between dark matter particles and nuclei in underground detectors. However these constraints weaken significantly in the sub-GeV mass region, simply because light dark matter does not have enough energy to trigger detectors regardless of the dark matter-nucleon scattering cross section. Even if future experiments lower their energy thresholds, they will still be blind to parameter space where dark matter particles interact with nuclei strongly enough that they lose enough energy and become unable to cause a signal above the experimental threshold by the time they reach the underground detector. Therefore in case dark matter is in the sub-GeV region and strongly interacting, possible underground scatterings of dark matter with terrestrial nuclei must be taken into account because they affect significantly the recoil spectra and event rates, regardless of whether the experiment probes DM via DM-nucleus or DM-electron interaction. To quantify this effect we present the publicly available Dark Matter Simulation Code for Underground Scatterings (DaMaSCUS), a Monte Carlo simulator of DM trajectories through the Earth taking underground scatterings into account. Our simulation allows the precise calculation of the density and velocity distribution of dark matter at any detector of given depth and location on Earth. The simulation can also provide the accurate recoil spectrum in underground detectors as well as the phase and amplitude of the diurnal modulation caused by this shadowing effect of the Earth, ultimately relating the modulations expected in different detectors, which is important to decisively conclude if a diurnal modulation is due to dark matter or an irrelevant background.

  7. Quark matter

    Energy Technology Data Exchange (ETDEWEB)

    Csernai, L.; Kampert, K. H.

    1994-10-15

    Precisely one decade ago the GSI (Darmstadt)/LBL (Berkeley) Collaboration at the Berkeley Bevalac reported clear evidence for collective sidewards flow in high energy heavy ion collisions. This milestone observation clearly displayed the compression and heating up of nuclear matter, providing new insights into how the behaviour of nuclear matter changes under very different conditions. This year, evidence for azimuthally asymmetric transverse flow at ten times higher projectile energy (11 GeV per nucleon gold on gold collisions) was presented by the Brookhaven E877 collaboration at the recent European Research Conference on ''Physics of High Energy Heavy Ion Collisions'', held in Helsinki from 17-22 June.

  8. Selected results on J/PSI hadronic decays from DM2 and Mark III

    International Nuclear Information System (INIS)

    Augustin, J.E.

    1985-01-01

    Results from the high statistics experiments Mark III and DM2 on J/PSI hadronic decays are reviewed. Special interest is given to SU3 violating decays into two pseudoscalars and baryon-antibaryon, especially the first observation of J/PSI → Ksub(S)sup(o)Ksub(L)sup(o). The complete measurement of the vector + pseudoscalar modes allows a new determination of the eta and eta' mixing parameters, indicating the presence of a new component in the eta' wave function. The iota(1440) and theta(1700) gluonium candidates have been searched for in hadronic decays, and the Mark III experiment observes a signal in J/PSI → ω iota (or ωE)

  9. Analysis and realization of a high resolution trigger for DM2 experiment

    International Nuclear Information System (INIS)

    Bertrand, J.L.

    1984-01-01

    The construction of a high resolution trigger has been carried out from its theoretical design to building. The term trigger is applied to an almost real-time system for track filtering in particle detection. Curved tracks are detected (with a magnetic field) and the detector is of a revolution symmetry type. The concept of a ''hybrid'' trigger with features in between those of the so-called ''CELLO R0'' and ''MARK II'' types is launched. It allows a positive versatility for the optimization of the different features. Besides a specific structure, some hardware and software implements have been designed for development and tests. The ''TRIGGER LENT'' is presently in operation in the DM2 experiment [fr

  10. Dynamics of Entanglement in Qubit-Qutrit with x-Component of DM Interaction

    International Nuclear Information System (INIS)

    Sharma, Kapil K.; Pandey, S.N.

    2016-01-01

    In this present paper, we study the entanglement dynamics in qubit A-qutrit B pair under x component of Dzyaloshinshkii–Moriya interaction (D x ) by taking an auxiliary qubit C. Here, we consider an entangled qubit-qutrit pair initially prepared in two parameter qubit-qutrit states and one auxiliary qubit prepared in pure state interacts with the qutrit of the pair through DM interaction. We trace away the auxiliary qubit and calculate the reduced dynamics in qubit A-qutrit B pair to study the influence of the state of auxiliary qubit C and D x on entanglement. We find that the state (probability amplitude) of auxiliary qubit does not influence the entanglement, only D x influences the same. The phenomenon of entanglement sudden death (ESD) induced by D x has also been observed. We also present the affected and unaffected two parameter qubit-qutrit states by D x . (paper)

  11. Radioactive Waste Management Basis

    International Nuclear Information System (INIS)

    Perkins, B.K.

    2009-01-01

    The purpose of this Radioactive Waste Management Basis is to describe the systematic approach for planning, executing, and evaluating the management of radioactive waste at LLNL. The implementation of this document will ensure that waste management activities at LLNL are conducted in compliance with the requirements of DOE Order 435.1, Radioactive Waste Management, and the Implementation Guide for DOE Manual 435.1-1, Radioactive Waste Management Manual. Technical justification is provided where methods for meeting the requirements of DOE Order 435.1 deviate from the DOE Manual 435.1-1 and Implementation Guide.

  12. Effect of some environmental parameters on fermentative hydrogen production by Enterobacter cloacae DM11

    Energy Technology Data Exchange (ETDEWEB)

    Nath, K.; Kumar, A.; Das, D. [Indian Inst. of Technology, Kharagpur (India). Dept. of Biotechnology, Fermentation Technology Laboratory

    2006-06-15

    This study addressed the issue of using biological systems for hydrogen production as an environmentally sound alternative to conventional thermochemical and electrochemical processes. In particular, it examined the potential for anaerobic fermentation for biological hydrogen production and the possibility of coupling gaseous energy generation with simultaneous treatment of biodegradable waste materials. The study focused on hydrogen production by anaerobic fermentation using Enterobacter cloacae DM11, a Gram-negative, motile facultative anaerobe. Although hydrogen production by these bacteria depends on many environmental parameters, there is very little information on the effects of these factors in the hydrogen production potential of this organism. For that reason, this study examined the effect of initial medium pH, reaction temperature, initial glucose concentration, and iron (Fe2+) concentration on the fermentative production of hydrogen. Fermentative hydrogen production was carried out by Enterobacter cloacae DM11, using glucose as the substrate. Batch cultivations were performed in a 500 ml custom-designed vertical tubular bioreactor. The maximum molar yield of hydrogen was 3.31 mol (mol glucose){sub 1}. The rate and cumulative volume of hydrogen production decreased at higher initial glucose concentration. The pH of 6.5 at a temperature of 37 degrees C was most suitable for maximum rate of production of hydrogen in batch fermentation. The addition of Fe2+ on hydrogen production had a marginal enhancing effect on total hydrogen production. A simple model developed from the modified Gompertz equation was used to fit the cumulative hydrogen production curve and to estimate the hydrogen production potential, maximum production rate, and lag time. It was concluded that these study results could be used in the development of a high rate continuous hydrogen production process. 30 refs., 4 tabs., 3 figs.

  13. The design of red-blue 3D video fusion system based on DM642

    Science.gov (United States)

    Fu, Rongguo; Luo, Hao; Lv, Jin; Feng, Shu; Wei, Yifang; Zhang, Hao

    2016-10-01

    Aiming at the uncertainty of traditional 3D video capturing including camera focal lengths, distance and angle parameters between two cameras, a red-blue 3D video fusion system based on DM642 hardware processing platform is designed with the parallel optical axis. In view of the brightness reduction of traditional 3D video, the brightness enhancement algorithm based on human visual characteristics is proposed and the luminance component processing method based on YCbCr color space is also proposed. The BIOS real-time operating system is used to improve the real-time performance. The video processing circuit with the core of DM642 enhances the brightness of the images, then converts the video signals of YCbCr to RGB and extracts the R component from one camera, so does the other video and G, B component are extracted synchronously, outputs 3D fusion images finally. The real-time adjustments such as translation and scaling of the two color components are realized through the serial communication between the VC software and BIOS. The system with the method of adding red-blue components reduces the lost of the chrominance components and makes the picture color saturation reduce to more than 95% of the original. Enhancement algorithm after optimization to reduce the amount of data fusion in the processing of video is used to reduce the fusion time and watching effect is improved. Experimental results show that the system can capture images in near distance, output red-blue 3D video and presents the nice experiences to the audience wearing red-blue glasses.

  14. Changes in endotoxin levels in T2DM subjects on anti-diabetic therapies

    Directory of Open Access Journals (Sweden)

    Kumar Sudhesh

    2009-04-01

    Full Text Available Abstract Introduction Chronic low-grade inflammation is a significant factor in the development of obesity associated diabetes. This is supported by recent studies suggesting endotoxin, derived from gut flora, may be key to the development of inflammation by stimulating the secretion of an adverse cytokine profile from adipose tissue. Aims The study investigated the relationship between endotoxin and various metabolic parameters of diabetic patients to determine if anti-diabetic therapies exerted a significant effect on endotoxin levels and adipocytokine profiles. Methods Fasting blood samples were collected from consenting Saudi Arabian patients (BMI: 30.2 ± (SD5.6 kg/m2, n = 413, consisting of non-diabetics (ND: n = 67 and T2DM subjects (n = 346. The diabetics were divided into 5 subgroups based on their 1 year treatment regimes: diet-controlled (n = 36, metformin (n = 141, rosiglitazone (RSG: n = 22, a combined fixed dose of metformin/rosiglitazone (met/RSG n = 100 and insulin (n = 47. Lipid profiles, fasting plasma glucose, insulin, adiponectin, resistin, TNF-α, leptin, C-reactive protein (CRP and endotoxin concentrations were determined. Results Regression analyses revealed significant correlations between endotoxin levels and triglycerides (R2 = 0.42; p 2 = 0.10; p 2 = 0.076; p 2 = 0.032; p 2 = 0.055; p Conclusion We conclude that sub-clinical inflammation in T2DM may, in part, be mediated by circulating endotoxin. Furthermore, that whilst the endotoxin and adipocytokine profiles of diabetic patients treated with different therapies were comparable, the RSG group demonstrated significant differences in both adiponectin and endotoxin levels. We confirm an association between endotoxin and serum insulin and triglycerides and an inverse relationship with HDL. Lower endotoxin and higher adiponectin in the groups treated with RSG may be related and indicate another mechanism for the effect of RSG on insulin sensitivity.

  15. Beam shaping by using small-aperture SLM and DM in a high power laser

    Science.gov (United States)

    Li, Sensen; Lu, Zhiwei; Du, Pengyuan; Wang, Yulei; Ding, Lei; Yan, Xiusheng

    2018-03-01

    High-power laser plays an important role in many fields, such as directed energy weapon, optoelectronic contermeasures, inertial confinement fusion, industrial processing and scientific research. The uniform nearfield and wavefront are the important part of the beam quality for high power lasers, which is conducive to maintaining the high spatial beam quality in propagation. We demonstrate experimentally that the spatial intensity and wavefront distribution at the output is well compensated in the complex high-power solid-state laser system by using the small-aperture spatial light modulator (SLM) and deformable mirror (DM) in the front stage. The experimental setup is a hundred-Joule-level Nd:glass laser system operating at three wavelengths at 1053 nm (1ω), 527 nm (2ω) and 351 nm (3ω) with 3 ns pulse duration with the final output beam aperture of 60 mm. While the clear arperture of the electrically addressable SLM is less than 20 mm and the effective diameter of the 52-actuators DM is about 15 mm. In the beam shaping system, the key point is that the two front-stage beam shaping devices needs to precompensate the gain nonuniform and wavefront distortion of the laser system. The details of the iterative algorithm for improving the beam quality are presented. Experimental results show that output nearfield and wavefont are both nearly flat-topped with the nearfield modulation of 1.26:1 and wavefront peak-to-valley value of 0.29 λ at 1053nm after beam shaping.

  16. Heavy spin-2 Dark Matter

    Energy Technology Data Exchange (ETDEWEB)

    Babichev, Eugeny [Laboratoire de Physique Théorique, CNRS, Univ. Paris-Sud, Université Paris-Saclay,91405 Orsay (France); UPMC-CNRS, UMR7095, Institut d’Astrophysique de Paris, GReCO,98bis boulevard Arago, F-75014 Paris (France); Marzola, Luca; Raidal, Martti [National Institute of Chemical Physics and Biophysics,Rävala 10, 10143 Tallinn (Estonia); Laboratory of Theoretical Physics, Institute of Physics, University of Tartu,Ravila 14c, 50411 Tartu (Estonia); Schmidt-May, Angnis [Institut für Theoretische Physik, Eidgenössische Technische Hochschule Zürich,Wolfgang-Pauli-Strasse 27, 8093 Zürich (Switzerland); Urban, Federico; Veermäe, Hardi [National Institute of Chemical Physics and Biophysics,Rävala 10, 10143 Tallinn (Estonia); Strauss, Mikael von [UPMC-CNRS, UMR7095, Institut d’Astrophysique de Paris, GReCO,98bis boulevard Arago, F-75014 Paris (France)

    2016-09-12

    We provide further details on a recent proposal addressing the nature of the dark sectors in cosmology and demonstrate that all current observations related to Dark Matter can be explained by the presence of a heavy spin-2 particle. Massive spin-2 fields and their gravitational interactions are uniquely described by ghost-free bimetric theory, which is a minimal and natural extension of General Relativity. In this setup, the largeness of the physical Planck mass is naturally related to extremely weak couplings of the heavy spin-2 field to baryonic matter and therefore explains the absence of signals in experiments dedicated to Dark Matter searches. It also ensures the phenomenological viability of our model as we confirm by comparing it with cosmological and local tests of gravity. At the same time, the spin-2 field possesses standard gravitational interactions and it decays universally into all Standard Model fields but not into massless gravitons. Matching the measured DM abundance together with the requirement of stability constrains the spin-2 mass to be in the 1 to 100 TeV range.

  17. Isotropic extragalactic flux from dark matter annihilations: lessons from interacting dark matter scenarios

    International Nuclear Information System (INIS)

    Moliné, Ángeles; Schewtschenko, Jascha A.; Boehm, Céline; Palomares-Ruiz, Sergio; Baugh, Carlton M.

    2016-01-01

    The extragalactic γ-ray and neutrino emission may have a contribution from dark matter (DM) annihilations. In the case of discrepancies between observations and standard predictions, one could infer the DM pair annihilation cross section into cosmic rays by studying the shape of the energy spectrum. So far all analyses of the extragalactic DM signal have assumed the standard cosmological model (ΛCDM) as the underlying theory. However, there are alternative DM scenarios where the number of low-mass objects is significantly suppressed. Therefore the characteristics of the γ-ray and neutrino emission in these models may differ from ΛCDM as a result. Here we show that the extragalactic isotropic signal in these alternative models has a similar energy dependence to that in ΛCDM, but the overall normalisation is reduced. The similarities between the energy spectra combined with the flux suppression could lead one to misinterpret possible evidence for models beyond ΛCDM as being due to CDM particles annihilating with a much weaker cross section than expected.

  18. Isotropic extragalactic flux from dark matter annihilations: lessons from interacting dark matter scenarios

    Energy Technology Data Exchange (ETDEWEB)

    Moliné, Ángeles [CFTP, Instituto Superior Tecnico, Universidade Tecnica de Lisboa, Av. Rovisco Pais 1, 1049-001 Lisboa (Portugal); Schewtschenko, Jascha A.; Boehm, Céline [Institute for Particle Physics Phenomenology (IPPP), Durham University, Durham DH1 3LE (United Kingdom); Palomares-Ruiz, Sergio [Instituto de Física Corpuscular (IFIC), CSIC-Universitat de València, Apartado de Correos 22085, E-46071 Valencia (Spain); Baugh, Carlton M., E-mail: maria.moline@ist.utl.pt, E-mail: jascha@schewtschenko.net, E-mail: Sergio.Palomares.Ruiz@ific.uv.es, E-mail: c.m.boehm@durham.ac.uk, E-mail: c.m.baugh@durham.ac.uk [Institute for Computational Cosmology (ICC), Durham University, Durham DH1 3LE (United Kingdom)

    2016-08-01

    The extragalactic γ-ray and neutrino emission may have a contribution from dark matter (DM) annihilations. In the case of discrepancies between observations and standard predictions, one could infer the DM pair annihilation cross section into cosmic rays by studying the shape of the energy spectrum. So far all analyses of the extragalactic DM signal have assumed the standard cosmological model (ΛCDM) as the underlying theory. However, there are alternative DM scenarios where the number of low-mass objects is significantly suppressed. Therefore the characteristics of the γ-ray and neutrino emission in these models may differ from ΛCDM as a result. Here we show that the extragalactic isotropic signal in these alternative models has a similar energy dependence to that in ΛCDM, but the overall normalisation is reduced. The similarities between the energy spectra combined with the flux suppression could lead one to misinterpret possible evidence for models beyond ΛCDM as being due to CDM particles annihilating with a much weaker cross section than expected.

  19. Super-cool Dark Matter arXiv

    CERN Document Server

    Hambye, Thomas; Teresi, Daniele

    In dimension-less theories of dynamical generation of the weak scale, the Universe can undergo a period of low-scale inflation during which all particles are massless and super-cool. This leads to a new mechanism of generation of the cosmological Dark Matter (DM) relic density: super-cooling can easily suppress the amount of DM to the desired level. This is achieved for TeV-scale DM, if super-cooling ends when quark condensates form at the QCD phase transition. Along this scenario, the baryon asymmetry can be generated either at the phase transition or through leptogenesis. We show that the above mechanism takes place in old and new dimension-less models.

  20. The Distribution and Annihilation of Dark Matter Around Black Holes

    Science.gov (United States)

    Schnittman, Jeremy D.

    2015-01-01

    We use a Monte Carlo code to calculate the geodesic orbits of test particles around Kerr black holes, generating a distribution function of both bound and unbound populations of dark matter (DM) particles. From this distribution function, we calculate annihilation rates and observable gamma-ray spectra for a few simple DM models. The features of these spectra are sensitive to the black hole spin, observer inclination, and detailed properties of the DM annihilation cross-section and density profile. Confirming earlier analytic work, we find that for rapidly spinning black holes, the collisional Penrose process can reach efficiencies exceeding 600%, leading to a high-energy tail in the annihilation spectrum. The high particle density and large proper volume of the region immediately surrounding the horizon ensures that the observed flux from these extreme events is non-negligible.

  1. Bottom quark contribution to spin-dependent dark matter detection

    Directory of Open Access Journals (Sweden)

    Jinmian Li

    2016-05-01

    Full Text Available We investigate a previously overlooked bottom quark contribution to the spin-dependent cross section for Dark Matter (DM scattering from the nucleon. While the mechanism is relevant to any supersymmetric extension of the Standard Model, for illustrative purposes we explore the consequences within the framework of the Minimal Supersymmetric Standard Model (MSSM. We study two cases, namely those where the DM is predominantly Gaugino or Higgsino. In both cases, there is a substantial, viable region in parameter space (mb˜−mχ≲O(100 GeV in which the bottom contribution becomes important. We show that a relatively large contribution from the bottom quark is consistent with constraints from spin-independent DM searches, as well as some incidental model dependent constraints.

  2. Searches for hadronically decaying Dark Matter mediator particles at ATLAS

    CERN Document Server

    Nindhito, Herjuno Rah

    2016-01-01

    Searches for hadronic resonances of the Dark Matter (DM) particles in the sub-TeV mass re- gion remain as a viable target at ATLAS. However, due to the bandwidth limitation, the events that available for performing an analysis were statistically limited. Reducing the event size by recording a fraction of the full event information overcomes this limitation. An analysis that is performed on those events is called Trigger-Level Analysis(TLA). This poster highlights the TLA strategy used to search for low-mass dijet resonances. No significant excesses are found in a region between 450 and 950 GeV. As an addition, limits are set on a simplified leptophobic Z’ model of DM mediator with axial coupling to quarks and DM particles as well as on Gaussian resonances.

  3. Towards the next generation of simplified Dark Matter models

    CERN Document Server

    Albert, Andreas

    This White Paper is an input to the ongoing discussion about the extension and refinement of simplified Dark Matter (DM) models. Based on two concrete examples, we show how existing simplified DM models (SDMM) can be extended to provide a more accurate and comprehensive framework to interpret and characterise collider searches. In the first example we extend the canonical SDMM with a scalar mediator to include mixing with the Higgs boson. We show that this approach not only provides a better description of the underlying kinematic properties that a complete model would possess, but also offers the option of using this more realistic class of scalar mixing models to compare and combine consistently searches based on different experimental signatures. The second example outlines how a new physics signal observed in a visible channel can be connected to DM by extending a simplified model including effective couplings. This discovery scenario uses the recently observed excess in the high-mass diphoton searches of...

  4. Dark matter and the Higgs in natural SUSY

    Energy Technology Data Exchange (ETDEWEB)

    Basirnia, Aria; Macaluso, Sebastian; Shih, David [NHETC, Department of Physics and Astronomy, Rutgers University, Piscataway, NJ 08854 (United States)

    2017-03-14

    Null results from dark matter (DM) direct detection experiments and the 125 GeV Higgs both pose serious challenges to minimal supersymmetry. In this paper, we propose a simple extension of the MSSM that economically solves both problems: a “dark sector” consisting of a singlet and a pair of SU(2) doublets. Loops of the dark sector fields help lift the Higgs mass to 125 GeV consistent with naturalness, while the lightest fermion in the dark sector can be viable thermal relic DM, provided that it is mostly singlet. The DM relic abundance is controlled by s-wave annihilation to tops and Higgsinos, leading to a tight relation between the relic abundance and the spin-dependent direct detection cross section. As a result, the model will be fully probed by the next generation of direct detection experiments. Finally we discuss the discovery potential at LHC Run II.

  5. Dark Matter

    Indian Academy of Sciences (India)

    As if this was not enough, it turns out that if our knowledge of ... are thought to contain dark matter, although the evidences from them are the .... protons, electrons, neutrons ... ratio of protons to neutrons was close to unity then as they were in ...

  6. Quantum matter

    International Nuclear Information System (INIS)

    Buechler, Hans Peter; Calcarco, Tommaso; Dressel, Martin

    2008-01-01

    The following topics are dealt with: Artificial atoms and molecules, tailored from solids, fractional flux quanta, molecular magnets, controlled interaction in quantum gases, the theory of quantum correlations in mott matter, cold gases, and mesoscopic systems, Bose-Einstein condensates on the chip, on the route to the quantum computer, a quantum computer in diamond. (HSI)

  7. Molecule Matters

    Indian Academy of Sciences (India)

    Home; Journals; Resonance – Journal of Science Education; Volume 14; Issue 4. Molecule Matters – van der Waals Molecules - History and Some Perspectives on Intermolecular Forces. E Arunan. Feature Article Volume 14 Issue 4 April 2009 pp 346-356 ...

  8. Molecule Matters

    Indian Academy of Sciences (India)

    Home; Journals; Resonance – Journal of Science Education; Volume 16; Issue 12. Molecule Matters - Dinitrogen. A G Samuelson J Jabadurai. Volume 16 Issue 12 ... Author Affiliations. A G Samuelson1 J Jabadurai1. Department of Inroganic and Physical Chemistry, Indian Institute of Science, Bangalore 560 012, India.

  9. Interstellar matter

    International Nuclear Information System (INIS)

    Mezger, P.G.

    1978-01-01

    An overview of the formation of our galaxy is presented followed by a summary of recent work in star formation and related topics. Selected discussions are given on interstellar matter including absorption characteristics of dust, the fully ionised component of the ISM and the energy density of lyc-photons in the solar neighbourhood and the diffuse galactic IR radiation

  10. Dark Matter

    Indian Academy of Sciences (India)

    The study of gas clouds orbiting in the outer regions of spiral galaxies has revealed that their gravitational at- traction is much larger than the stars alone can provide. Over the last twenty years, astronomers have been forced to postulate the presence of large quantities of 'dark matter' to explain their observations. They are ...

  11. Molecule Matters

    Indian Academy of Sciences (India)

    Home; Journals; Resonance – Journal of Science Education; Volume 11; Issue 9. Molecule Matters - A Chromium Compound with a Quintuple Bond. K C Kumara Swamy. Feature Article Volume 11 Issue 9 September 2006 pp 72-75. Fulltext. Click here to view fulltext PDF. Permanent link:

  12. Distinct roles of the DmNav and DSC1 channels in the action of DDT and pyrethroids.

    Science.gov (United States)

    Rinkevich, Frank D; Du, Yuzhe; Tolinski, Josh; Ueda, Atsushi; Wu, Chun-Fang; Zhorov, Boris S; Dong, Ke

    2015-03-01

    Voltage-gated sodium channels (Nav channels) are critical for electrical signaling in the nervous system and are the primary targets of the insecticides DDT and pyrethroids. In Drosophila melanogaster, besides the canonical Nav channel, Para (also called DmNav), there is a sodium channel-like cation channel called DSC1 (Drosophila sodium channel 1). Temperature-sensitive paralytic mutations in DmNav (para(ts)) confer resistance to DDT and pyrethroids, whereas DSC1 knockout flies exhibit enhanced sensitivity to pyrethroids. To further define the roles and interaction of DmNav and DSC1 channels in DDT and pyrethroid neurotoxicology, we generated a DmNav/DSC1 double mutant line by introducing a para(ts1) allele (carrying the I265N mutation) into a DSC1 knockout line. We confirmed that the I265N mutation reduced the sensitivity to two pyrethroids, permethrin and deltamethrin of a DmNav variant expressed in Xenopus oocytes. Computer modeling predicts that the I265N mutation confers pyrethroid resistance by allosterically altering the second pyrethroid receptor site on the DmNav channel. Furthermore, we found that I265N-mediated pyrethroid resistance in para(ts1) mutant flies was almost completely abolished in para(ts1);DSC1(-/-) double mutant flies. Unexpectedly, however, the DSC1 knockout flies were less sensitive to DDT, compared to the control flies (w(1118A)), and the para(ts1);DSC1(-/-) double mutant flies were even more resistant to DDT compared to the DSC1 knockout or para(ts1) mutant. Our findings revealed distinct roles of the DmNav and DSC1 channels in the neurotoxicology of DDT vs. pyrethroids and implicate the exciting possibility of using DSC1 channel blockers or modifiers in the management of pyrethroid resistance. Copyright © 2015 Elsevier Inc. All rights reserved.

  13. Clinical efficacy and safety of T-DM1 for patients with HER2-positive breast cancer

    Directory of Open Access Journals (Sweden)

    Ma B

    2016-02-01

    Full Text Available Bo Ma,1 Qianqian Ma,2 Hongqiang Wang,3 Guolei Zhang,1 Huiying Zhang,1 Xiaohong Wang1 1Affiliated Central Hospital of Huzhou Teachers College, Huzhou, Zhejiang, People’s Republic of China; 2University Hospital of Tuebingen, Tuebingen, Germany; 3Department of Oncology, Hospital of Zhoushan, Zhoushan, Zhejiang, People’s Republic of China Purpose: The aim of this study was to evaluate the therapeutic efficacy and safety of trastuzumab emtansine (T-DM1 for the treatment of patients with human epidermal growth factor receptor 2-positive breast cancer.  Methods: We performed a systemic review and meta-analysis of the relevant published clinical studies. A computerized search was performed for controlled clinical trials of T-DM1 in targeted treatment. Overall survival, progression-free survival, objective response rate, symptom progression free, and adverse events (AEs were evaluated.  Results: Eight eligible trials with a total of 2,016 patients with breast cancer were included in the present meta-analysis. The treatment of patients with breast cancer with T-DM1 was associated with significantly increased overall and progression-free survival when compared with controls (P<0.0001. An analysis of the objective response rate and symptom progression free also demonstrated favorable results for T-DM1 treatment (P≤0.0001. There was no significant difference between the T-DM1 and control groups with respect to nonhematologic or hematologic AEs (P=0.99 and P=0.30, respectively.  Conclusion: Overall, T-DM1 is efficacious in the treatment of patients with human epidermal growth factor receptor 2-positive breast cancer and low rates of AEs compared with controls. Keywords: breast cancer, meta-analysis, HER2, T-DM1, efficacy

  14. Preclinical safety profile of trastuzumab emtansine (T-DM1): Mechanism of action of its cytotoxic component retained with improved tolerability

    Energy Technology Data Exchange (ETDEWEB)

    Poon, Kirsten Achilles, E-mail: achilles.kirsten@gene.com [Genentech, Inc., South San Francisco, CA (United States); Flagella, Kelly; Beyer, Joseph [Genentech, Inc., South San Francisco, CA (United States); Tibbitts, Jay [UCB, Brussels (Belgium); Kaur, Surinder; Saad, Ola; Yi, Joo-Hee; Girish, Sandhya; Dybdal, Noel; Reynolds, Theresa [Genentech, Inc., South San Francisco, CA (United States)

    2013-12-01

    Trastuzumab emtansine (T-DM1) is the first antibody-drug conjugate (ADC) approved for patients with human epidermal growth factor receptor 2 (HER2)-positive metastatic breast cancer. The therapeutic premise of ADCs is based on the hypothesis that targeted delivery of potent cytotoxic drugs to tumors will provide better tolerability and efficacy compared with non-targeted delivery, where poor tolerability can limit efficacious doses. Here, we present results from preclinical studies characterizing the toxicity profile of T-DM1, including limited assessment of unconjugated DM1. T-DM1 binds primate ErbB2 and human HER2 but not the rodent homolog c-neu. Therefore, antigen-dependent and non-antigen-dependent toxicity was evaluated in monkeys and rats, respectively, in both single- and repeat-dose studies; toxicity of DM1 was assessed in rats only. T-DM1 was well tolerated at doses up to 40 mg/kg (∼ 4400 μg DM1/m{sup 2}) and 30 mg/kg (∼ 6000 μg DM1/m{sup 2}) in rats and monkeys, respectively. In contrast, DM1 was only tolerated up to 0.2 mg/kg (1600 μg DM1/m{sup 2}). This suggests that at least two-fold higher doses of the cytotoxic agent are tolerated in T-DM1, supporting the premise of ADCs to improve the therapeutic index. In addition, T-DM1 and DM1 safety profiles were similar and consistent with the mechanism of action of DM1 (i.e., microtubule disruption). Findings included hepatic, bone marrow/hematologic (primarily platelet), lymphoid organ, and neuronal toxicities, and increased numbers of cells of epithelial and phagocytic origin in metaphase arrest. These adverse effects did not worsen with chronic dosing in monkeys and are consistent with those reported in T-DM1-treated patients to date. - Highlights: • T-DM1 was well tolerated in preclinical studies in rats and cynomolgus monkeys. • T-DM1 is associated with bone marrow/hematologic, hepatic, and neuronal toxicities. • T-DM1 toxicities are related to DM1 mechanisms of action and pharmacologic

  15. Dark Matter

    International Nuclear Information System (INIS)

    Audouze, J.; Tran Thanh Van, J.

    1988-01-01

    The book begins with the papers devoted to the experimental search of signatures of the dark matter which governs the evolution of the Universe as a whole. A series of contributions describe the presently considered experimental techniques (cryogenic detectors, supraconducting detectors...). A real dialogue concerning these techniques has been instaured between particle physicists and astrophysicists. After the progress report of the particle physicists, the book provides the reader with an updated situation concerning the research in cosmology. The second part of the book is devoted to the analysis of the backgrounds at different energies such as the possible role of the cooling flows in the constitution of massive galactic halos. Any search of dark matter implies necessarily the analysis of the spatial distributions of the large scale structures of the Universe. This report is followed by a series of statistical analyses of these distributions. These analyses concern mainly universes filled up with cold dark matter. The last paper of this third part concerns the search of clustering in the spatial distribution of QSOs. The presence of dark matter should affect the solar neighborhood and related to the existence of galactic haloes. The contributions are devoted to the search of such local dark matter. Primordial nucleosynthesis provides a very powerful tool to set up quite constraining limitations on the overall baryonic density. Even if on takes into account the inhomogeneities in density possibly induced by the Quark-Hadron transition, this baryonic density should be much lower than the overall density deduced from the dynamical models of Universe or the inflationary theories

  16. Multiwavelength analysis of dark matter annihilation and RX-DMFIT

    International Nuclear Information System (INIS)

    McDaniel, A.; Jeltema, T.; Profumo, S.; Storm, E.

    2017-01-01

    Dark matter (DM) particles are predicted by several well motivated models to yield Standard Model particles through self-annihilation that can potentially be detected by astrophysical observations. In particular, the production of charged particles from DM annihilation in astrophysical systems that contain magnetic fields yields radio emission through synchrotron radiation and X-ray emission through inverse Compton scattering of ambient photons. We introduce RX-DMFIT, a tool used for calculating the expected secondary emission from DM annihilation. RX-DMFIT includes a wide range of customizable astrophysical and particle parameters and incorporates important astrophysics including the diffusion of charged particles, relevant radiative energy losses, and magnetic field modelling. We demonstrate the use and versatility of RX-DMFIT by analyzing the potential radio and X-ray signals for a variety of DM particle models and astrophysical environments including galaxy clusters, dwarf spheroidal galaxies and normal galaxies. We then apply RX-DMFIT to a concrete example using Segue I radio data to place constraints for a range of assumed DM annihilation channels. For WIMP models with M χ ≤ 100 GeV and assuming weak diffusion, we find that the leptonic μ + μ − and τ + τ − final states provide the strongest constraints, placing limits on the DM particle cross-section well below the thermal relic cross-section, while even for the b b-bar channel we find limits close to the thermal relic cross-section. Our analysis shows that radio emission provides a highly competitive avenue for dark matter searches.

  17. Multiwavelength analysis of dark matter annihilation and RX-DMFIT

    Energy Technology Data Exchange (ETDEWEB)

    McDaniel, A.; Jeltema, T.; Profumo, S. [Department of Physics, University of California, 1156 High St. Santa Cruz, CA, 95064 (United States); Storm, E., E-mail: alexmcdaniel@ucsc.edu, E-mail: tesla@ucsc.edu, E-mail: profumo@ucsc.edu, E-mail: e.m.storm@uva.nl [GRAPPA, Institute of Physics, Universiteit van Amsterdam Science Park 904, 1098XH Amsterdam (Netherlands)

    2017-09-01

    Dark matter (DM) particles are predicted by several well motivated models to yield Standard Model particles through self-annihilation that can potentially be detected by astrophysical observations. In particular, the production of charged particles from DM annihilation in astrophysical systems that contain magnetic fields yields radio emission through synchrotron radiation and X-ray emission through inverse Compton scattering of ambient photons. We introduce RX-DMFIT, a tool used for calculating the expected secondary emission from DM annihilation. RX-DMFIT includes a wide range of customizable astrophysical and particle parameters and incorporates important astrophysics including the diffusion of charged particles, relevant radiative energy losses, and magnetic field modelling. We demonstrate the use and versatility of RX-DMFIT by analyzing the potential radio and X-ray signals for a variety of DM particle models and astrophysical environments including galaxy clusters, dwarf spheroidal galaxies and normal galaxies. We then apply RX-DMFIT to a concrete example using Segue I radio data to place constraints for a range of assumed DM annihilation channels. For WIMP models with M {sub χ} ≤ 100 GeV and assuming weak diffusion, we find that the leptonic μ{sup +}μ{sup −} and τ{sup +}τ{sup −} final states provide the strongest constraints, placing limits on the DM particle cross-section well below the thermal relic cross-section, while even for the b b-bar channel we find limits close to the thermal relic cross-section. Our analysis shows that radio emission provides a highly competitive avenue for dark matter searches.

  18. The search for decaying Dark Matter

    CERN Document Server

    Herder, J W den; Ruchayskiy, O.; Abazajian, K.; Frenk, C.; Hansen, S.; Jonker, P.; Kouveliotou, C.; Lesgourgues, J.; Neronov, A.; Ohashi, T.; Paerels, F.; Paltani, S.; Piro, L.; Pohl, M.; Shaposhnikov, M.; Silk, J.; Valle, J.W.F.

    2009-01-01

    We propose an X-ray mission called Xenia to search for decaying superweakly interacting Dark Matter particles (super-WIMP) with a mass in the keV range. The mission and its observation plan are capable of providing a major break through in our understanding of the nature of Dark Matter (DM). It will confirm, or reject, predictions of a number of particle physics models by increasing the sensitivity of the search for decaying DM by about two orders of magnitude through a wide-field imaging X-ray spectrometer in combination with a dedicated observation program. The proposed mission will provide unique limits on the mixing angle and mass of neutral leptons, right handed partners of neutrinos, which are important Dark Matter candidates. The existence of these particles is strongly motivated by observed neutrino flavor oscillations and the problem of baryon asymmetry of the Universe. In super-WIMP models, the details of the formation of the cosmic web are different from those of LambdaCDM. The proposed mission wil...

  19. Singlet fermionic dark matter with Veltman conditions

    Science.gov (United States)

    Kim, Yeong Gyun; Lee, Kang Young; Nam, Soo-hyeon

    2018-07-01

    We reexamine a renormalizable model of a fermionic dark matter with a gauge singlet Dirac fermion and a real singlet scalar which can ameliorate the scalar mass hierarchy problem of the Standard Model (SM). Our model setup is the minimal extension of the SM for which a realistic dark matter (DM) candidate is provided and the cancellation of one-loop quadratic divergence to the scalar masses can be achieved by the Veltman condition (VC) simultaneously. This model extension, although renormalizable, can be considered as an effective low-energy theory valid up to cut-off energies about 10 TeV. We calculate the one-loop quadratic divergence contributions of the new scalar and fermionic DM singlets, and constrain the model parameters using the VC and the perturbative unitarity conditions. Taking into account the invisible Higgs decay measurement, we show the allowed region of new physics parameters satisfying the recent measurement of relic abundance. With the obtained parameter set, we predict the elastic scattering cross section of the new singlet fermion into target nuclei for a direct detection of the dark matter. We also perform the full analysis with arbitrary set of parameters without the VC as a comparison, and discuss the implication of the constraints by the VC in detail.

  20. ITER technical basis

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2002-01-01

    Following on from the Final Report of the EDA(DS/21), and the summary of the ITER Final Design report(DS/22), the technical basis gives further details of the design of ITER. It is in two parts. The first, the Plant Design specification, summarises the main constraints on the plant design and operation from the viewpoint of engineering and physics assumptions, compliance with safety regulations, and siting requirements and assumptions. The second, the Plant Description Document, describes the physics performance and engineering characteristics of the plant design, illustrates the potential operational consequences foe the locality of a generic site, gives the construction, commissioning, exploitation and decommissioning schedule, and reports the estimated lifetime costing based on data from the industry of the EDA parties.

  1. ITER technical basis

    International Nuclear Information System (INIS)

    2002-01-01

    Following on from the Final Report of the EDA(DS/21), and the summary of the ITER Final Design report(DS/22), the technical basis gives further details of the design of ITER. It is in two parts. The first, the Plant Design specification, summarises the main constraints on the plant design and operation from the viewpoint of engineering and physics assumptions, compliance with safety regulations, and siting requirements and assumptions. The second, the Plant Description Document, describes the physics performance and engineering characteristics of the plant design, illustrates the potential operational consequences foe the locality of a generic site, gives the construction, commissioning, exploitation and decommissioning schedule, and reports the estimated lifetime costing based on data from the industry of the EDA parties

  2. Neurobiological basis of PTSD

    International Nuclear Information System (INIS)

    Yamasue, Hidenori; Kasai, Kiyoto

    2006-01-01

    This review describes posttraumatic stress disorder (PTSD) from the aspect that it is one of precious neurobiological models where the stress caused by an outer environmental factor affects the livings afterwards. Also described are the actual imaging investigations of PTSD in people encountered the sarin subway terrorism in Tokyo (1995). High resolution MRI has revealed the decreased volume of hippocampus in PTSD patients in recent years. In victims of the terrorism above, authors have found that the volume of anterior cingulate cortical (ACC) gray matter is reduced in voxel-based MRI morphometry and the reduction is well correlated with PTSD severity and lower P300 amplitude. PET and fMRI have shown the hyperactivity of amygdala and hypoactivity of medial prefrontal region around ACC in PTSD. Findings in conditioned animal studies have indicated the importance of ACC neuronal cell activation for fear extinction, where, in humans, fMRI has revealed the cooperation between amygdala and ACC. At present, genetic factors like serotonin transporter polymorphism, environmental ones at infantile stage and their interactive activity are subject to investigation and discussion. Imaging studies will contribute to the clinical diagnosis, treatment and intervention of PTSD. (T.I)

  3. H.E.S.S. OBSERVATIONS OF THE GLOBULAR CLUSTERS NGC 6388 AND M15 AND SEARCH FOR A DARK MATTER SIGNAL

    International Nuclear Information System (INIS)

    Abramowski, A.; Acero, F.; Aharonian, F.; Bernloehr, K.; Bochow, A.; Akhperjanian, A. G.; Anton, G.; Balzer, A.; Brucker, J.; Barnacka, A.; Barres de Almeida, U.; Bazer-Bachi, A. R.; Borrel, V.; Becherini, Y.; Becker, J.; Behera, B.; Boisson, C.; Bolmont, J.; Bordas, P.

    2011-01-01

    Observations of the globular clusters (GCs) NGC 6388 and M15 were carried out by the High Energy Stereoscopic System array of Cherenkov telescopes for a live time of 27.2 and 15.2 hr, respectively. No gamma-ray signal is found at the nominal target position of NGC 6388 and M15. In the primordial formation scenario, GCs are formed in a dark matter (DM) halo and DM could still be present in the baryon-dominated environment of GCs. This opens the possibility of observing a DM self-annihilation signal. The DM content of the GCs NGC 6388 and M15 is modeled taking into account the astrophysical processes that can be expected to influence the DM distribution during the evolution of the GC: the adiabatic contraction of DM by baryons, the adiabatic growth of a black hole in the DM halo, and the kinetic heating of DM by stars. Ninety-five percent confidence level exclusion limits on the DM particle velocity-weighted annihilation cross section are derived for these DM halos. In the TeV range, the limits on the velocity-weighted annihilation cross section are derived at the 10 -25 cm 3 s -1 level and a few 10 -24 cm 3 s -1 for NGC 6388 and M15, respectively.

  4. Sense Training as Basis for Aesthetic Experience

    DEFF Research Database (Denmark)

    Thomsen, Bente Dahl

    2016-01-01

    . It is a special problem for design engineers, who must guarantee the aesthetic, ethical and utilitarian qualities of products in a product development process. It does not matter whether they or other designers have conceived the product idea. It has been found that sense training can open up to aesthetic...... and train their specification of the basis for aesthetic experiences. The context for the study is a course and a project in interaction design about designing rehabilitation products, where undergraduate students must develop a project program with focus on theoretical scientific research and experiment...

  5. Disposal Of Waste Matter

    International Nuclear Information System (INIS)

    Kim, Jeong Hyeon; Lee, Seung Mu

    1989-02-01

    This book deals with disposal of waste matter management of soiled waste matter in city with introduction, definition of waste matter, meaning of management of waste matter, management system of waste matter, current condition in the country, collect and transportation of waste matter disposal liquid waste matter, industrial waste matter like plastic, waste gas sludge, pulp and sulfuric acid, recycling technology of waste matter such as recycling system of Black clawson, Monroe and Rome.

  6. Dark Matter characterization at the LHC in the Effective Field Theory approach

    Energy Technology Data Exchange (ETDEWEB)

    Belyaev, Alexander; Panizzi, Luca [School of Physics and Astronomy, University of Southampton,Southampton SO17 1BJ (United Kingdom); Particle Physics Department, Rutherford Appleton Laboratory,Didcot, Oxon OX11 0QX (United Kingdom); Pukhov, Alexander [Skobeltsyn Institute of Nuclear Physics, Moscow State University,Moscow 119992 (Russian Federation); Thomas, Marc [School of Physics and Astronomy, University of Southampton,Southampton SO17 1BJ (United Kingdom); Particle Physics Department, Rutherford Appleton Laboratory,Didcot, Oxon OX11 0QX (United Kingdom)

    2017-04-19

    We have studied the complete set of dimension 5 and dimension 6 effective operators involving the interaction of scalar, fermion and vector Dark Matter (DM) with SM quarks and gluons, to explore the possibility to distinguish these operators and characterise the spin of DM at the LHC. We have found that three factors — the effective dimension of the operator, the structure of the SM part of the operator and the parton densities of the SM particles connected to the operator — uniquely define the shape of the (unobservable) invariant mass distribution of the DM pair and, consequently, the shape of the (observable) E{sub T}{sup miss} distribution related to it. Using χ{sup 2} analysis, we found that at the LHC, with a luminosity of 300 fb{sup −1}, certain classes of EFT operators can be distinguished from each other. Hence, since DM spin is partly correlated with the factors defining the shape of E{sub T}{sup miss}, the LHC can potentially shed a light also on DM spin. We have also observed a drastic difference in the efficiencies (up to two orders of magnitude) for large E{sub T}{sup miss} cuts scenarios with different DM spin, thus indicating that the DM discovery potential strongly depends on it. The study we perform here can be applied more generally than within the EFT paradigm, where the DM mediator is not produced on-the-mass-shell, such as the case of t-channel mediator or mediator with mass below 2M{sub DM}, where the invariant mass of the DM pair is not fixed.

  7. Simplified dark matter models with charged mediators: prospects for direct detection

    Energy Technology Data Exchange (ETDEWEB)

    Sandick, Pearl; Sinha, Kuver; Teng, Fei [Department of Physics and Astronomy, University of Utah,Salt Lake City, UT 84112 (United States)

    2016-10-05

    We consider direct detection prospects for a class of simplified models of fermionic dark matter (DM) coupled to left and right-handed Standard Model fermions via two charged scalar mediators with arbitrary mixing angle α. DM interactions with the nucleus are mediated by higher electromagnetic moments, which, for Majorana DM, is the anapole moment. After giving a full analytic calculation of the anapole moment, including its α dependence, and matching with limits in the literature, we compute the DM-nucleon scattering cross-section and show the LUX and future LZ constraints on the parameter space of these models. We then compare these results with constraints coming from Fermi-LAT continuum and line searches. Results in the supersymmetric limit of these simplified models are provided in all cases. We find that future direct detection experiments will be able to probe most of the parameter space of these models for O(100−200) GeV DM and lightest mediator mass ≲O(5%) larger than the DM mass. The direct detection prospects dwindle for larger DM mass and larger mass gap between the DM and the lightest mediator mass, although appreciable regions are still probed for O(200) GeV DM and lightest mediator mass ≲O(20%) larger than the DM mass. The direct detection bounds are also attenuated near certain “blind spots' in the parameter space, where the anapole moment is severely suppressed due to cancellation of different terms. We carefully study these blind spots and the associated Fermi-LAT signals in these regions.

  8. Dark Matter characterization at the LHC in the Effective Field Theory approach

    Science.gov (United States)

    Belyaev, Alexander; Panizzi, Luca; Pukhov, Alexander; Thomas, Marc

    2017-04-01

    We have studied the complete set of dimension 5 and dimension 6 effective operators involving the interaction of scalar, fermion and vector Dark Matter (DM) with SM quarks and gluons, to explore the possibility to distinguish these operators and characterise the spin of DM at the LHC. We have found that three factors — the effective dimension of the operator, the structure of the SM part of the operator and the parton densities of the SM particles connected to the operator — uniquely define the shape of the (unobservable) invariant mass distribution of the DM pair and, consequently, the shape of the (observable) E T miss distribution related to it. Using χ2 analysis, we found that at the LHC, with a luminosity of 300 fb-1, certain classes of EFT operators can be distinguished from each other. Hence, since DM spin is partly correlated with the factors defining the shape of E T miss , the LHC can potentially shed a light also on DM spin. We have also observed a drastic difference in the efficiencies (up to two orders of magnitude) for large E T miss cuts scenarios with different DM spin, thus indicating that the DM discovery potential strongly depends on it. The study we perform here can be applied more generally than within the EFT paradigm, where the DM mediator is not produced on-the-mass-shell, such as the case of t-channel mediator or mediator with mass below 2 M DM, where the invariant mass of the DM pair is not fixed.

  9. A food additive with prebiotic properties of an α-d-glucan from lactobacillus plantarum DM5.

    Science.gov (United States)

    Das, Deeplina; Baruah, Rwivoo; Goyal, Arun

    2014-08-01

    An α-d-glucan produced by Lactobacillus plantarum DM5 was explored for in vitro prebiotic activities. Glucan-DM5 demonstrated 21.6% solubility, 316.9% water holding capacity, 86.2% flocculation activity, 71.4% emulsification activity and a degradation temperature (Td) of 292.2°C. Glucan-DM5 exhibited lowest digestibility of 0.54% by artificial gastric juice, 0.21% by intestinal fluid and 0.32% by α-amylase whereas the standard prebiotic inulin, showed 25.23%, 5.97% and 19.13%, hydrolysis, respectively. Prebiotic activity assay of glucan-DM5 displayed increased growth of probiotic bacteria such as Bifidobacterium infantis and Lactobacillus acidophilus, but did not support the growth of non-probiotic bacteria such as Escherichia coli and Enterobacter aerogenes. The overall findings indicated that glucan from L. plantarum DM5 can serve as a potential prebiotic additive for food products. Copyright © 2014 Elsevier B.V. All rights reserved.

  10. Dark matter that can form dark stars

    International Nuclear Information System (INIS)

    Gondolo, Paolo; Huh, Ji-Haeng; Kim, Hyung Do; Scopel, Stefano

    2010-01-01

    The first stars to form in the Universe may be powered by the annihilation of weakly interacting dark matter particles. These so-called dark stars, if observed, may give us a clue about the nature of dark matter. Here we examine which models for particle dark matter satisfy the conditions for the formation of dark stars. We find that in general models with thermal dark matter lead to the formation of dark stars, with few notable exceptions: heavy neutralinos in the presence of coannihilations, annihilations that are resonant at dark matter freeze-out but not in dark stars, some models of neutrinophilic dark matter annihilating into neutrinos only and lighter than about 50 GeV. In particular, we find that a thermal DM candidate in standard Cosmology always forms a dark star as long as its mass is heavier than ≅ 50 GeV and the thermal average of its annihilation cross section is the same at the decoupling temperature and during the dark star formation, as for instance in the case of an annihilation cross section with a non-vanishing s-wave contribution

  11. Direct detection of exothermic dark matter with light mediator

    Energy Technology Data Exchange (ETDEWEB)

    Geng, Chao-Qiang [Chongqing University of Posts & Telecommunications,Chongqing, 400065 (China); Department of Physics, National Tsing Hua University,Hsinchu, Taiwan (China); Physics Division, National Center for Theoretical Sciences,Hsinchu, Taiwan (China); Huang, Da; Lee, Chun-Hao [Department of Physics, National Tsing Hua University,Hsinchu, Taiwan (China); Wang, Qing [Department of Physics, Tsinghua University,Beijing, 100084 (China); Collaborative Innovation Center of Quantum Matter,Beijing, 100084 (China)

    2016-08-05

    We study the dark matter (DM) direct detection for the models with the effects of the isospin-violating couplings, exothermic scatterings, and/or the lightness of the mediator, proposed to relax the tension between the CDMS-Si signals and null experiments. In the light of the new updates of the LUX and CDMSlite data, we find that many of the previous proposals are now ruled out, including the Ge-phobic exothermic DM model and the Xe-phobic DM one with a light mediator. We also examine the exothermic DM models with a light mediator but without the isospin violation, and we are unable to identify any available parameter space that could simultaneously satisfy all the experiments. The only models that can partially relax the inconsistencies are the Xe-phobic exothermic DM models with or without a light mediator. But even in this case, a large portion of the CDMS-Si regions of interest has been constrained by the LUX and SuperCDMS data.

  12. THE EFFECTS OF DARK MATTER ANNIHILATION ON COSMIC REIONIZATION

    Energy Technology Data Exchange (ETDEWEB)

    Kaurov, Alexander A.; Hooper, Dan; Gnedin, Nickolay Y., E-mail: kaurov@uchicago.edu [Department of Astronomy and Astrophysics, The University of Chicago, Chicago, IL 60637 (United States)

    2016-12-20

    We revisit the possibility of constraining the properties of dark matter (DM) by studying the epoch of cosmic reionization. Previous studies have shown that DM annihilation was unlikely to have provided a large fraction of the photons which ionized the universe, but instead played a subdominant role relative to stars and quasars. The DM might, however, have begun to efficiently annihilate with the formation of primordial microhalos at z  ∼ 100–200, much earlier than the formation of the first stars. Therefore, if DM annihilation ionized the universe at even the percent level over the interval z  ∼ 20–100, it could leave a significant imprint on the global optical depth, τ . Moreover, we show that cosmic microwave background polarization data and future 21 cm measurements will enable us to more directly probe the DM contribution to the optical depth. In order to compute the annihilation rate throughout the epoch of reionization, we adopt the latest results from structure formation studies and explore the impact of various free parameters on our results. We show that future measurements could make it possible to place constraints on the DM’s annihilation cross-sections, which are at a level comparable to those obtained from the observations of dwarf galaxies, cosmic-ray measurements, and studies of recombination.

  13. Effects of QCD bound states on dark matter relic abundance

    Energy Technology Data Exchange (ETDEWEB)

    Liew, Seng Pei [Department of Physics, The University of Tokyo,Bunkyo-ku, Tokyo 113-0033 (Japan); Luo, Feng [Kavli IPMU (WPI), UTIAS, The University of Tokyo,Kashiwa, Chiba 277-8583 (Japan)

    2017-02-17

    We study scenarios where there exists an exotic massive particle charged under QCD in the early Universe. We calculate the formation and dissociation rates of bound states formed by pairs of these particles, and apply the results in dark matter (DM) coannihilation scenarios, including also the Sommerfeld effect. We find that on top of the Sommerfeld enhancement, bound-state effects can further significantly increase the largest possible DM masses which can give the observed DM relic abundance, by ∼30–100% with respect to values obtained by considering the Sommerfeld effect only, for the color triplet or octet exotic particles we consider. In particular, it indicates that the Bino DM mass in the right-handed stop-Bino coannihilation scenario in the Minimal Supersymmetric extension of the Standard Model (MSSM) can reach ∼2.5 TeV, even though the potential between the stop and antistop prior to forming a bound state is repulsive. We also apply the bound-state effects in the calculations of relic abundance of long-lived or metastable massive colored particles, and discuss the implications on the BBN constraints and the abundance of a super-weakly interacting DM. The corrections for the bound-state effect when the exotic massive colored particles also carry electric charges, and the collider bounds are also discussed.

  14. Using MT2 to distinguish dark matter stabilization symmetries

    International Nuclear Information System (INIS)

    Agashe, Kaustubh; Kim, Doojin; Zhu Lijun; Walker, Devin G. E.

    2011-01-01

    We examine the potential of using colliders to distinguish models with parity (Z 2 ) stabilized dark matter (DM) from models in which the DM is stabilized by other symmetries, taking the latter to be a Z 3 symmetry for illustration. The key observation is that a heavier mother particle charged under a Z 3 stabilization symmetry can decay into one or two DM particles along with standard model particles. This can be contrasted with the decay of a mother particle charged under a parity symmetry; typically, only one DM particle appears in the decay chain. The arXiv:1003.0899 studied the distributions of visible invariant mass from the decay of a single such mother particle in order to highlight the resulting distinctive signatures of Z 3 symmetry versus parity symmetry stabilized dark matter candidates. We now describe a complementary study which focuses on decay chains of the two mother particles which are necessarily present in these events. We also include in our analysis the missing energy/momentum in the event. For the Z 3 symmetry stabilized mothers, the resulting inclusive final state can have two, three or four DM particles. In contrast, models with Z 2 symmetry can have only two. We show that the shapes and edges of the distribution of M T2 -type variables, along with ratio of the visible momentum/energy on the two sides of the event, are powerful in distinguishing these different scenarios. Finally we conclude by outlining future work which focuses on reducing combinatoric ambiguities from reconstructing multijet events. Increasing the reconstruction efficiency can allow better reconstruction of events with two or three dark matter candidates in the final state.

  15. Quark matter

    International Nuclear Information System (INIS)

    Csernai, L.; Kampert, K.H.

    1994-01-01

    Precisely one decade ago the GSI (Darmstadt)/LBL (Berkeley) Collaboration at the Berkeley Bevalac reported clear evidence for collective sidewards flow in high energy heavy ion collisions. This milestone observation clearly displayed the compression and heating up of nuclear matter, providing new insights into how the behaviour of nuclear matter changes under very different conditions. This year, evidence for azimuthally asymmetric transverse flow at ten times higher projectile energy (11 GeV per nucleon gold on gold collisions) was presented by the Brookhaven E877 collaboration at the recent European Research Conference on ''Physics of High Energy Heavy Ion Collisions'', held in Helsinki from 17-22 June

  16. T2DM Self-Management via Smartphone Applications: A Systematic Review and Meta-Analysis.

    Science.gov (United States)

    Cui, Mingxuan; Wu, Xueyan; Mao, Jiangfeng; Wang, Xi; Nie, Min

    2016-01-01

    Mobile health interventions (mHealth) based on smartphone applications (apps) are promising tools to help improve diabetes care and self-management; however, more evidence on the efficacy of mHealth in diabetes care is needed. The objective of this study was to conduct a systematic review and meta-analysis of randomized controlled trials (RCTs) assessing the effect of mHealth apps on changes in hemoglobin A1c (HbA1c), blood glucose, blood pressure, serum lipids, and body weight in type 2 diabetes mellitus (T2DM) patients. Two independent reviewers searched three online databases (PubMed, the Cochrane Library, and EMBASE) to identify relevant studies published between January 2005 and June 2016. Of the 2,596 articles retrieved, 13 RCTs were included. We used random effects model to estimate the pooled results. Thirteen studies were selected for the systematic review, six of which with data available containing 1,022 patients were included for the meta-analysis. There was a moderate effect on glycemic control after the mHealth app-based interventions. The overall effect on HbA1c shown as mean difference (MD) was -0.40% (-4.37 mmol/mol) (95% confidence interval [CI] -0.69 to -0.11% [-7.54 to -1.20 mmol/mol]; p = 0.007) and standardized mean differences (SMD) was -0.40% (-4.37 mmol/mol) (95% confidence interval [CI] -0.69 to -0.10% [-7.54 to -1.09 mmol/mol]; p = 0.008). A subgroup analysis showed a similar effect with -0.33% (-3.61 mmol/mol) (95% CI -0.59 to -0.06% [-6.45 to -0.66 mmol/mol]; p = 0.02) in MD and -0.38% (-4.15 mmol/mol) (95% CI -0.71 to -0.05% [-7.76 to -0.55 mmol/mol]; p = 0.02) in SMD in studies where patients' baseline HbA1c levels were less than 8.0%. No effects of mHealth app interventions were found on blood pressure, serum lipids, or weight. Assessment of overall study quality and publication bias demonstrated a low risk of bias among the six studies. Smartphone apps offered moderate benefits for T2DM self-management. However, more research with

  17. Sharing but not caring. Dark matter and the baryon asymmetry of the universe

    Energy Technology Data Exchange (ETDEWEB)

    Bernal, Nicolas [Universidad Estadual Paulista, Sao Paulo (Brazil). Inst. de Fisica Teorica; Austrian Academy of Sciences, Vienna (Austria). Inst. of High Energy Physics; Fong, Chee Sheng [Sao Paulo Univ. (Brazil). Inst. de Fisica; Fonseca, Nayara [Sao Paulo Univ. (Brazil). Inst. de Fisica; Deutsches Elektronen-Synchrotron (DESY), Hamburg (Germany)

    2016-09-15

    We consider scenarios where Dark Matter (DM) particles carry baryon and/or lepton numbers, which can be defined if there exist operators connecting the dark to the visible sector. As a result, the DM fields become intimately linked to the Standard Model (SM) ones and can be maximally asymmetric just like the ordinary matter. In particular, we discuss minimal scenarios where the DM is a complex scalar or a Dirac fermion coupled to operators with nonzero baryon and/or lepton numbers, and that consist of only SM fields. We consider an initial asymmetry stored in either the SM or the DM sector; the main role of these operators is to properly share the asymmetry between the two sectors, in accordance with observations. After the chemical decoupling, the DM and SM sectors do not care about each other as there is only an ineffective communication between them. Once the DM mass is specified, the Wilson coefficients of these operators are fixed by the requirement of the correct transfer of the asymmetry. We study the phenomenology of this framework at colliders, direct detection and indirect detection experiments. In particular, the LHC phenomenology is very rich and can be tested in different channels such as the two same-sign leptons with two jets, monojet and monojet with a monolepton.

  18. Sharing but not caring: dark matter and the baryon asymmetry of the universe

    Energy Technology Data Exchange (ETDEWEB)

    Bernal, Nicolás [ICTP South American Institute for Fundamental Research, Instituto de Física Teórica, Universidade Estadual Paulista,R. Dr. Bento Teobaldo Ferraz 271, 01140-070 São Paulo (Brazil); Institute of High Energy Physics, Austrian Academy of Sciences,Nikolsdorfer Gasse 18, 1050 Vienna (Austria); Fong, Chee Sheng [Instituto de Física, Universidade de São Paulo,Rua do Matão 1371, 05508-090 São Paulo (Brazil); Fonseca, Nayara [Instituto de Física, Universidade de São Paulo,Rua do Matão 1371, 05508-090 São Paulo (Brazil); DESY,Notkestraße 85, 22607 Hamburg (Germany)

    2016-09-02

    We consider scenarios where Dark Matter (DM) particles carry baryon and/or lepton numbers, which can be defined if there exist operators connecting the dark to the visible sector. As a result, the DM fields become intimately linked to the Standard Model (SM) ones and can be maximally asymmetric just like the ordinary matter. In particular, we discuss minimal scenarios where the DM is a complex scalar or a Dirac fermion coupled to operators with nonzero baryon and/or lepton numbers, and that consist of only SM fields. We consider an initial asymmetry stored in either the SM or the DM sector; the main role of these operators is to properly share the asymmetry between the two sectors, in accordance with observations. After the chemical decoupling, the DM and SM sectors do not care about each other as there is only an ineffective communication between them. Once the DM mass is specified, the Wilson coefficients of these operators are fixed by the requirement of the correct transfer of the asymmetry. We study the phenomenology of this framework at colliders, direct detection and indirect detection experiments. In particular, the LHC phenomenology is very rich and can be tested in different channels such as the two same-sign leptons with two jets, monojet and monojet with a monolepton.

  19. Fermi-LAT kills dark matter interpretations of AMS-02 data. Or not?

    Energy Technology Data Exchange (ETDEWEB)

    Belotsky, Konstantin; Budaev, Ruslan; Kirillov, Alexander; Laletin, Maxim, E-mail: k-belotsky@yandex.ru, E-mail: buday48@mail.ru, E-mail: AAKirillov@mephi.ru, E-mail: maxim.laletin@ulg.ac.be [Department of Elementary Particle Physics, National Research Nuclear University MEPhI, 115409 Kashirskoe shosse 31, Moscow (Russian Federation)

    2017-01-01

    A number of papers attempt to explain the positron anomaly in cosmic rays, observed by PAMELA and AMS-02, in terms of dark matter (DM) decays or annihilations. However, the recent progress in cosmic gamma-ray studies challenges these attempts. Indeed, as we show, any rational DM model explaining the positron anomaly abundantly produces final state radiation and Inverse Compton gamma rays, which inevitably leads to a contradiction with Fermi-LAT isotropic diffuse gamma-ray background measurements. Furthermore, the Fermi-LAT observation of Milky Way dwarf satellites, supposed to be rich in DM, revealed no significant signal in gamma rays. We propose a generic approach in which the major contribution to cosmic rays comes from the dark matter disc and prove that the tension between the DM origin of the positron anomaly and the cosmic gamma-ray observations can be relieved. We consider both a simple model, in which DM decay/annihilate into charged leptons, and a model-independent minimal case of particle production, and we estimate the optimal thickness of DM disk. Possible mechanisms of formation and its properties are briefly discussed.

  20. Solar neutrinos as a probe of dark matter-neutrino interactions

    Energy Technology Data Exchange (ETDEWEB)

    Capozzi, Francesco; Vecchi, Luca [Dipartimento di Fisica e Astronomia, Università di Padova, via Marzolo 8, I-35131 Padova (Italy); Shoemaker, Ian M., E-mail: capozzi.12@osu.edu, E-mail: ian.shoemaker@usd.edu, E-mail: vecchi@infn.pd.it [Department of Physics, University of South Dakota, Vermillion, SD 57069 (United States)

    2017-07-01

    Sterile neutrinos at the eV scale have long been studied in the context of anomalies in short baseline neutrino experiments. Their cosmology can be made compatible with our understanding of the early Universe provided the sterile neutrino sector enjoys a nontrivial dynamics with exotic interactions, possibly providing a link to the Dark Matter (DM) puzzle. Interactions between DM and neutrinos have also been proposed to address the long-standing 'missing satellites' problem in the field of large scale structure formation. Motivated by these considerations, in this paper we discuss realistic scenarios with light steriles coupled to DM . We point out that within this framework active neutrinos acquire an effective coupling to DM that manifests itself as a new matter potential in the propagation within a medium of asymmetric DM . Assuming that at least a small fraction of asymmetric DM has been captured by the Sun, we show that a sizable region of the parameter space of these scenarios can be probed by solar neutrino experiments, especially in the regime of small couplings and light mediators where all other probes become inefficient. In the latter regime these scenarios behave as familiar 3+1 models in all channels except for solar data, where a Solar Dark MSW effect takes place. Solar Dark MSW is characterized by modifications of the most energetic {sup 8}B and CNO neutrinos, whereas the other fluxes remain largely unaffected.

  1. Sharing but not caring. Dark matter and the baryon asymmetry of the universe

    International Nuclear Information System (INIS)

    Bernal, Nicolas

    2016-09-01

    We consider scenarios where Dark Matter (DM) particles carry baryon and/or lepton numbers, which can be defined if there exist operators connecting the dark to the visible sector. As a result, the DM fields become intimately linked to the Standard Model (SM) ones and can be maximally asymmetric just like the ordinary matter. In particular, we discuss minimal scenarios where the DM is a complex scalar or a Dirac fermion coupled to operators with nonzero baryon and/or lepton numbers, and that consist of only SM fields. We consider an initial asymmetry stored in either the SM or the DM sector; the main role of these operators is to properly share the asymmetry between the two sectors, in accordance with observations. After the chemical decoupling, the DM and SM sectors do not care about each other as there is only an ineffective communication between them. Once the DM mass is specified, the Wilson coefficients of these operators are fixed by the requirement of the correct transfer of the asymmetry. We study the phenomenology of this framework at colliders, direct detection and indirect detection experiments. In particular, the LHC phenomenology is very rich and can be tested in different channels such as the two same-sign leptons with two jets, monojet and monojet with a monolepton.

  2. Higgs decays to dark matter: Beyond the minimal model

    International Nuclear Information System (INIS)

    Pospelov, Maxim; Ritz, Adam

    2011-01-01

    We examine the interplay between Higgs mediation of dark-matter annihilation and scattering on one hand and the invisible Higgs decay width on the other, in a generic class of models utilizing the Higgs portal. We find that, while the invisible width of the Higgs to dark matter is now constrained for a minimal singlet scalar dark matter particle by experiments such as XENON100, this conclusion is not robust within more generic examples of Higgs mediation. We present a survey of simple dark matter scenarios with m DM h /2 and Higgs portal mediation, where direct-detection signatures are suppressed, while the Higgs width is still dominated by decays to dark matter.

  3. Probing dark matter with star clusters: a dark matter core in the ultra-faint dwarf Eridanus II

    Science.gov (United States)

    Contenta, Filippo; Balbinot, Eduardo; Petts, James A.; Read, Justin I.; Gieles, Mark; Collins, Michelle L. M.; Peñarrubia, Jorge; Delorme, Maxime; Gualandris, Alessia

    2018-05-01

    We present a new technique to probe the central dark matter (DM) density profile of galaxies that harnesses both the survival and observed properties of star clusters. As a first application, we apply our method to the `ultra-faint' dwarf Eridanus II (Eri II) that has a lone star cluster ˜45 pc from its centre. Using a grid of collisional N-body simulations, incorporating the effects of stellar evolution, external tides and dynamical friction, we show that a DM core for Eri II naturally reproduces the size and the projected position of its star cluster. By contrast, a dense cusped galaxy requires the cluster to lie implausibly far from the centre of Eri II (>1 kpc), with a high inclination orbit that must be observed at a particular orbital phase. Our results, therefore, favour a DM core. This implies that either a cold DM cusp was `heated up' at the centre of Eri II by bursty star formation or we are seeing an evidence for physics beyond cold DM.

  4. [Determination of fat, protein and DM in raw milk by portable short-wave near infrared spectrometer].

    Science.gov (United States)

    Li, Xiao-yun; Wang, Jia-hua; Huang, Ya-wei; Han, Dong-hai

    2011-03-01

    Near infrared diffuse reflectance spectroscopy calibrations of fat, protein and DM in raw milk were studied with partial least-squares (PLS) regression using portable short-wave near infrared spectrometer. The results indicated that good calibrations of fat and DM were found, the correlation coefficients were all 0.98, the RMSEC were 0.187 and 0.217, RMSEP were 0.187 and 0.296, the RPDs were 5.02 and 3.20 respectively; the calibration of protein needed to be improved but can be used for practice, the correlation coefficient was 0.95, RMSEC was 0.105, RMSEP was 0.120, and RPD was 2.60. Furthermore, the measuring accuracy was improved by analyzing the correction relation of fat and DM in raw milk This study will probably provide a new on-site method for nondestructive and rapid measurement of milk.

  5. Phenomenological and Astro-particle analysis of light dark matter particles

    International Nuclear Information System (INIS)

    Albornoz Vasquez, D.

    2011-09-01

    The nature of Dark Matter (DM) is still unveiled. Experimental efforts aiming to detect the Dark Matter have shown a great progress in the last decade. This work is devoted to the phenomenological and astro-particle studies of Dark Matter candidates of supersymmetric nature - the neutralino - and beyond - scalar particles. The former, in the (1-100) GeV mass range, is currently being tested by the Large Hadron Collider, direct detection and indirect detection experiments; this work shows that the interplay between experimental techniques is a decisive tool to thoroughly search for theoretical predictions. The latter is a non-standard candidate as light as 1 MeV which could be copiously produced at the Large Hadron Collider and, at the same time, it could explain other phenomena such as neutrino masses and/or the 511 keV line from the galactic center of the Milky Way. We start by describing the DM problem in Part I, where we give a review for evidence of the existence of DM, we set the cosmological framework in which we work and describe the history of DM from the Early Universe (EU), to the formation of structure and up to the current distribution of the DM in haloes. Then, in Part II, we go through the important Cosmological, Astro-particle and Particle Physics constraints to particle DM candidates and subsequently introduce models providing relatively light DM candidates, models of standard supersymmetric nature such as the Minimal Supersymmetric Standard Model (MSSM) and the Next-to-MSSM (NMSSM) with neutralino DM, and beyond N=1 SUSY in a light scalar DM scenario inspired in N=2 SUSY. Finally, in Part III we present the findings of the investigations carried out: we describe a numerical tool developed to scan the multidimensional supersymmetric parameter space, then we present an application of this tool to the search of light neutralino configurations in the MSSM and NMSSM as well as an application to the search for neutralino DM in directional detectors, and

  6. Systematic problems with using dark matter simulations to model stellar halos

    International Nuclear Information System (INIS)

    Bailin, Jeremy; Bell, Eric F.; Valluri, Monica; Stinson, Greg S.; Debattista, Victor P.; Couchman, H. M. P.; Wadsley, James

    2014-01-01

    The limits of available computing power have forced models for the structure of stellar halos to adopt one or both of the following simplifying assumptions: (1) stellar mass can be 'painted' onto dark matter (DM) particles in progenitor satellites; (2) pure DM simulations that do not form a luminous galaxy can be used. We estimate the magnitude of the systematic errors introduced by these assumptions using a controlled set of stellar halo models where we independently vary whether we look at star particles or painted DM particles, and whether we use a simulation in which a baryonic disk galaxy forms or a matching pure DM simulation that does not form a baryonic disk. We find that the 'painting' simplification reduces the halo concentration and internal structure, predominantly because painted DM particles have different kinematics from star particles even when both are buried deep in the potential well of the satellite. The simplification of using pure DM simulations reduces the concentration further, but increases the internal structure, and results in a more prolate stellar halo. These differences can be a factor of 1.5-7 in concentration (as measured by the half-mass radius) and 2-7 in internal density structure. Given this level of systematic uncertainty, one should be wary of overinterpreting differences between observations and the current generation of stellar halo models based on DM-only simulations when such differences are less than an order of magnitude.

  7. The capture of dark matter particles through the evolution of low-mass stars

    International Nuclear Information System (INIS)

    Lopes, Ilidio; Casanellas, Jordi; Eugenio, Daniel

    2011-01-01

    We studied the rate at which stars capture dark matter (DM) particles, considering different assumptions regarding the DM characteristics and, in particular, investigating how the stellar physics influences the capture rate. Two scenarios were considered: first, we assumed the maximal values for the spin-dependent and spin-independent DM particle-nucleon scattering cross sections allowed by the limits from direct detection experiments. Second, we considered that both scattering cross sections are of the same order, with the aim of studying the dependencies of the capture rate on stellar elements other than hydrogen. We found that the characteristics of the capture rate are very different in the two scenarios. Furthermore, we quantified the uncertainties on the computed capture rate (C χ ) and on the ratio between the luminosities from DM annihilations and thermonuclear reactions (L χ /L nuc ) derived from an imprecise knowledge of the stellar structure and DM parameters. For instance, while an uncertainty of 10% on the typical DM velocity leads to similar errors on the computed C χ and L χ /L nuc , the same uncertainty on the stellar mass becomes more relevant and duplicates the errors. Our results may be used to evaluate the reliability of the computed capture rate for the hypothetical use of stars other than the Sun as DM probes.

  8. Spherical harmonics analysis of Fermi gamma-ray data and the Galactic dark matter halo

    International Nuclear Information System (INIS)

    Malyshev, Dmitry; Bovy, Jo; Cholis, Ilias

    2011-01-01

    We argue that the decomposition of gamma-ray maps in spherical harmonics is a sensitive tool to study dark matter (DM) annihilation or decay in the main Galactic halo of the Milky Way. Using the spherical harmonic decomposition in a window excluding the Galactic plane, we show for 1 yr of Fermi data that adding a spherical template (such as a line-of-sight DM annihilation profile) to an astrophysical background significantly reduces χ 2 of the fit to the data. In some energy bins the significance of this DM fraction is above three sigma. This can be viewed as a hint of a DM annihilation signal, although astrophysical sources cannot be ruled out at this moment. We use the derived DM fraction as a conservative upper limit on the DM annihilation signal. In the case of bb annihilation channel the limits are about a factor of 2 less constraining than the limits from dwarf galaxies. The uncertainty of our method is dominated by systematics related to modeling the astrophysical background. We show that with 1 yr of Fermi data the statistical sensitivity would be sufficient to detect DM annihilation with thermal freeze-out cross section for masses below 100 GeV.

  9. Study of the boxlike dark matter signals from dwarf spheroidal galaxies with Fermi-LAT data

    Science.gov (United States)

    Li, Shang; Liang, Yun-Feng; Xia, Zi-Qing; Zu, Lei; Duan, Kai-Kai; Shen, Zhao-Qiang; Feng, Lei; Yuan, Qiang; Fan, Yi-Zhong

    2018-04-01

    The observation of a special spectral feature in the gamma-ray data would be one of the best ways to identify dark matter (DM). The box-shaped gamma-ray spectra could be generated by the decay of intermediate particles produced by DM annihilation or decay. It provides another kind of signal that can be relatively easily distinguished from astrophysical backgrounds besides the linelike signals. Dwarf spheroidal galaxies are expected to be dominated by DM and may be one of the most promising targets for indirect DM searches. In this paper, we study the box-shaped DM signals with Fermi-LAT observations of dwarf spheroidal galaxies. We analyze 106 months of Fermi-LAT data to derive the upper limits on the annihilation cross section or the decay timescale of DM. In addition, we compare the results for different sample selections and DM density distributions. We expect that more dwarf spheroidal galaxies will be found and the sensitivity of box-shaped gamma-ray signal searches will be significantly improved in the future.

  10. Dark Matter and observable lepton flavour violation

    International Nuclear Information System (INIS)

    Heurtier, Lucien; Univ. Libre de Bruxelles; Teresi, Daniele

    2016-07-01

    Seesaw models with leptonic symmetries allow right-handed (RH) neutrino masses at the electroweak scale, or even lower, at the same time having large Yukawa couplings with the Standard Model leptons, thus yielding observable effects at current or near-future lepton-flavour-violation (LFV) experiments. These models have been previously considered also in connection to low-scale leptogenesis, but the combination of observable LFV and successful leptogenesis has appeared to be difficult to achieve unless the leptonic symmetry is embedded into a larger one. In this paper, instead, we follow a different route and consider a possible connection between large LFV rates and Dark Matter (DM). We present a model in which the same leptonic symmetry responsible for the large Yukawa couplings guarantees the stability of the DM candidate, identified as the lightest of the RH neutrinos. The spontaneous breaking of this symmetry, caused by a Majoron-like field, also provides a mechanism to produce the observed relic density via the decays of the latter. The phenomenological implications of the model are discussed, finding that large LFV rates, observable in the near-future μ→e conversion experiments, require the DM mass to be in the keV range. Moreover, the active-neutrino coupling to the Majoron-like scalar field could be probed in future detections of supernova neutrino bursts.

  11. Supersymmetric Dark Matter after LHC Run 1

    CERN Document Server

    Bagnaschi, E.A.; Cavanaugh, R.; Citron, M.; De Roeck, A.; Dolan, M.J.; Ellis, J.R.; Flächer, H.; Heinemeyer, S.; Isidori, G.; Malik, S.; Martínez Santos, D.; Olive, K.A.; Sakurai, K.; de Vries, K.J.; Weiglein, G.

    2015-10-23

    Different mechanisms operate in various regions of the MSSM parameter space to bring the relic density of the lightest neutralino, neutralino_1, assumed here to be the LSP and thus the Dark Matter (DM) particle, into the range allowed by astrophysics and cosmology. These mechanisms include coannihilation with some nearly-degenerate next-to-lightest supersymmetric particle (NLSP) such as the lighter stau (stau_1), stop (stop_1) or chargino (chargino_1), resonant annihilation via direct-channel heavy Higgs bosons H/A, the light Higgs boson h or the Z boson, and enhanced annihilation via a larger Higgsino component of the LSP in the focus-point region. These mechanisms typically select lower-dimensional subspaces in MSSM scenarios such as the CMSSM, NUHM1, NUHM2 and pMSSM10. We analyze how future LHC and direct DM searches can complement each other in the exploration of the different DM mechanisms within these scenarios. We find that the stau_1 coannihilation regions of the CMSSM, NUHM1, NUHM2 can largely be exp...

  12. Neutrino-Flavoured Sneutrino Dark Matter

    CERN Document Server

    March-Russell, John; McCullough, Matthew

    2010-01-01

    A simple theory of supersymmetric dark matter (DM) naturally linked to neutrino flavour physics is studied. The DM sector comprises a spectrum of mixed lhd-rhd sneutrino states where both the sneutrino flavour structure and mass splittings are determined by the associated neutrino masses and mixings. Prospects for indirect detection from solar capture are good due to a large sneutrino-nucleon cross-section afforded by the inelastic splitting (solar capture limits exclude an explanation of DAMA/LIBRA). We find parameter regions where all heavier states will have decayed, leaving only one flavour mixture of sneutrino as the candidate DM. Such regions have a unique `smoking gun' signature--sneutrino annihilation in the Sun produces a pair of neutrino mass eigenstates free from vacuum oscillations, with the potential for detection at neutrino telescopes through the observation of a hard spectrum of nu_mu and nu_tau (for a normal neutrino hierarchy). Next generation direct detection experiments can explore much of...

  13. DNA Damage Observed in Unaffected Individuals with Family History of T2DM

    Science.gov (United States)

    Ramesh, Nikhila; Abilash, V. G.

    2017-11-01

    Diabetes has been documented to cause high levels of DNA fragmentation in some cases. As diabetes is inheritable and influenced by both genetic and environmental factors, an investigation into the genomic stability of individuals who are strongly at risk of inheriting diabetes was conducted by inducing oxidative stress, as DNA damage in unaffected individuals could be a sign of onset of the disease or the presence of genetic alterations that reduce cellular defences against reactive oxygen species. In this study, alkaline comet assay was performed on isolated human leukocytes to determine whether individuals with a family history of Type 2 Diabetes Mellitus (T2DM) are more prone to DNA damage under oxidative stress. Visual scoring of comets showed that these individuals have higher degree of DNA damage compared to a control individual with no family history of Type 2 Diabetes Mellitus. Further studies with large sample could determine the presence of disabled cellular defences against oxidative stress in unaffected individuals and intervention with antioxidants could prevent or manage Type 2 Diabetes Mellitus and its complications.

  14. Crystal Structure of Allophycocyanin from Marine Cyanobacterium Phormidium sp. A09DM.

    Directory of Open Access Journals (Sweden)

    Ravi Raghav Sonani

    Full Text Available Isolated phycobilisome (PBS sub-assemblies have been widely subjected to X-ray crystallography analysis to obtain greater insights into the structure-function relationship of this light harvesting complex. Allophycocyanin (APC is the phycobiliprotein always found in the PBS core complex. Phycocyanobilin (PCB chromophores, covalently bound to conserved Cys residues of α- and β- subunits of APC, are responsible for solar energy absorption from phycocyanin and for transfer to photosynthetic apparatus. In the known APC structures, heterodimers of α- and β- subunits (known as αβ monomers assemble as trimer or hexamer. We here for the first time report the crystal structure of APC isolated from a marine cyanobacterium (Phormidium sp. A09DM. The crystal structure has been refined against all the observed data to the resolution of 2.51 Å to Rwork (Rfree of 0.158 (0.229 with good stereochemistry of the atomic model. The Phormidium protein exists as a trimer of αβ monomers in solution and in crystal lattice. The overall tertiary structures of α- and β- subunits, and trimeric quaternary fold of the Phormidium protein resemble the other known APC structures. Also, configuration and conformation of the two covalently bound PCB chromophores in the marine APC are same as those observed in fresh water cyanobacteria and marine red algae. More hydrophobic residues, however, constitute the environment of the chromophore bound to α-subunit of the Phormidium protein, owing mainly to amino acid substitutions in the marine protein.

  15. THE DISTRIBUTION AND CHEMISTRY OF H2CO IN THE DM TAU PROTOPLANETARY DISK

    International Nuclear Information System (INIS)

    Loomis, Ryan A.; Öberg, Karin I.; Guzman, Viviana V.; Cleeves, L. Ilsedore; Andrews, Sean M.

    2015-01-01

    H 2 CO ice on dust grains is an important precursor of complex organic molecules (COMs). H 2 CO gas can be readily observed in protoplanetary disks and may be used to trace COM chemistry. However, its utility as a COM probe is currently limited by a lack of constraints on the relative contributions of two different formation pathways: on icy grain surfaces and in the gas phase. We use archival Atacama Large (sub-)Millimeter Array observations of the resolved distribution of H 2 CO emission in the disk around the young low-mass star DM Tau to assess the relative importance of these formation routes. The observed H 2 CO emission has a centrally peaked and radially broad brightness profile (extending out to 500 AU). We compare these observations with disk chemistry models with and without grain-surface formation reactions and find that both gas and grain-surface chemistry are necessary to explain the spatial distribution of the emission. Gas-phase H 2 CO production is responsible for the observed central peak, while grain-surface chemistry is required to reproduce the emission exterior to the CO snow line (where H 2 CO mainly forms through the hydrogenation of CO ice before being non-thermally desorbed). These observations demonstrate that both gas and grain-surface pathways contribute to the observed H 2 CO in disks and that their relative contributions depend strongly on distance from the host star

  16. Influence of ring size on the cognition-enhancing activity of DM235 and MN19, two potent nootropic drugs.

    Science.gov (United States)

    Guandalini, L; Martini, E; Di Cesare Mannelli, L; Dei, S; Manetti, D; Scapecchi, S; Teodori, E; Ghelardini, C; Romanelli, M N

    2012-03-01

    A series of analogs of DM235 and MN19, characterized by rings with different size, have been prepared and evaluated for their nootropic activity in the mouse passive-avoidance test. It was found that the optimal ring size for the analogs of DM235, showing endocyclic both amidic groups, is 6 or 7 atoms. For the compounds structurally related to MN19, carrying an exocyclic amide group, the piperidine ring is the moiety which gives the most interesting compounds. Copyright © 2012 Elsevier Ltd. All rights reserved.

  17. Substituted piperazines as nootropic agents: 2- or 3-phenyl derivatives structurally related to the cognition-enhancer DM235.

    Science.gov (United States)

    Guandalini, Luca; Martino, Maria Vittoria; Di Cesare Mannelli, Lorenzo; Bartolucci, Gianluca; Melani, Fabrizio; Malik, Ruchi; Dei, Silvia; Floriddia, Elisa; Manetti, Dina; Orlandi, Francesca; Teodori, Elisabetta; Ghelardini, Carla; Romanelli, Maria Novella

    2015-04-15

    A series of 2-phenyl- or 3-phenyl piperazines, structurally related to DM235 and DM232, two potent nootropic agents, have been prepared and tested in the mouse passive-avoidance test, to assess their ability to revert scopolamine-induced amnesia. Although the newly synthesized molecules were less potent than the parent compounds, some useful information has been obtained from structure-activity relationships. A small but significant enantioselectivity has been found for the most potent compound 5a. Copyright © 2015 Elsevier Ltd. All rights reserved.

  18. MR spectroscopy of cerebral white matter in type 2 diabetes; no association with clinical variables and cognitive performance

    Energy Technology Data Exchange (ETDEWEB)

    Tiehuis, Audrey; Meer, Femke van der; Mali, Willem; Luijten, Peter [University Medical Center Utrecht, Department of Radiology (Hp E01.332), PO Box 85500, GA, Utrecht (Netherlands); Pleizier, Marc; Biessels, Geert Jan; Kappelle, Jaap [University Medical Center Utrecht, Department of Neurology, Rudolf Magnus Institute of Neuroscience, Utrecht (Netherlands)

    2010-02-15

    Type 2 diabetes (DM2) is associated with cognitive decline, but the pathogenesis of this important complication remains unclear. We investigated whether abnormalities in neuronal metabolism or membrane integrity in normal appearing cerebral white matter are associated with cognitive impairment in patients with DM2. Single voxel proton magnetic resonance spectroscopy (1.5 T), aimed at N-acetyl-aspartate (NAA), total choline (Cho), and total creatine (Cr), was performed in the cerebral white matter (centrum semiovale) of 72 patients with DM2 and 40 control subjects. All participants underwent extensive neuropsychological evaluation. Patients with DM2 performed worse with respect to global neuropsychological functioning than controls (p < 0.05), in particular on memory and information processing speed. We observed no differences in NAA/Cr, Cho/Cr, or NAA/Cho ratio's between patients with DM2 and controls. Cognitive performance in patients with DM2 was not correlated with any of these brain metabolites, neither were the clinical variables. We conclude that disturbances in neuronal viability and cellular membrane status assessed by NAA/Cr, Cho/Cr, NAA/Cho ratios cannot explain cognitive decline in patients with DM2. (orig.)

  19. MR spectroscopy of cerebral white matter in type 2 diabetes; no association with clinical variables and cognitive performance

    International Nuclear Information System (INIS)

    Tiehuis, Audrey; Meer, Femke van der; Mali, Willem; Luijten, Peter; Pleizier, Marc; Biessels, Geert Jan; Kappelle, Jaap

    2010-01-01

    Type 2 diabetes (DM2) is associated with cognitive decline, but the pathogenesis of this important complication remains unclear. We investigated whether abnormalities in neuronal metabolism or membrane integrity in normal appearing cerebral white matter are associated with cognitive impairment in patients with DM2. Single voxel proton magnetic resonance spectroscopy (1.5 T), aimed at N-acetyl-aspartate (NAA), total choline (Cho), and total creatine (Cr), was performed in the cerebral white matter (centrum semiovale) of 72 patients with DM2 and 40 control subjects. All participants underwent extensive neuropsychological evaluation. Patients with DM2 performed worse with respect to global neuropsychological functioning than controls (p < 0.05), in particular on memory and information processing speed. We observed no differences in NAA/Cr, Cho/Cr, or NAA/Cho ratio's between patients with DM2 and controls. Cognitive performance in patients with DM2 was not correlated with any of these brain metabolites, neither were the clinical variables. We conclude that disturbances in neuronal viability and cellular membrane status assessed by NAA/Cr, Cho/Cr, NAA/Cho ratios cannot explain cognitive decline in patients with DM2. (orig.)

  20. Anisotropies in the diffuse gamma-ray background from dark matter with Fermi LAT: a closer look

    DEFF Research Database (Denmark)

    Cuoco, Alessandro; Sellerholm, A.; Conrad, J.

    2011-01-01

    We perform a detailed study of the sensitivity to the anisotropies related to dark matter (DM) annihilation in the isotropic gamma-ray background (IGRB) as measured by the Fermi Large Area Telescope (Fermi LAT). For the first time, we take into account the effects of the Galactic foregrounds...... of the detector are taken into account by convolving the model maps with the Fermi LAT instrumental response. We then use the angular power spectrum to characterize the anisotropy properties of the simulated data and to study the sensitivity to DM. We consider DM anisotropies of extragalactic origin...

  1. White clover fractions as protein source for monogastrics - Dry matter digestibility and Protein Digestibility-Corrected Amino Acid Scores

    DEFF Research Database (Denmark)

    Stødkilde, Lene; Damborg, Vinni K; Jørgensen, Henry

    2018-01-01

    BACKGROUND: The aim was to evaluate white clover as an alternative protein source for monogastrics. White clover plant and leaves were processed using a screw-press resulting in a solid pulp and a juice from which protein was acid-precipitated. The chemical composition of all fractions...... was determined and digestibility of dry matter (DM) and protein was assessed in an experiment with growing rats. RESULTS: Protein concentrates were produced with crude protein (CP) content of 451 g/kg DM and 530 g/kg DM for white clover plant and leaves, respectively and a pulp with CP content of 313 and 374 g...

  2. Signals of composite electroweak-neutral Dark Matter: LHC/direct detection interplay

    International Nuclear Information System (INIS)

    Barbieri, Riccardo; Rychkov, Slava; Torre, Riccardo

    2010-01-01

    In a strong-coupling picture of ElectroWeak Symmetry Breaking, a composite electroweak-neutral state in the TeV mass range, carrying a global (quasi-)conserved charge, makes a plausible Dark Matter (DM) candidate, with the ongoing direct DM searches being precisely sensitive to the expected signals. To exploit the crucial interplay between direct DM searches and the LHC, we consider a composite iso-singlet vector V, mixed with the hypercharge gauge field, as the essential mediator of the interaction between the DM particle and the nucleus. Based on a suitable effective chiral Lagrangian, we give the expected properties and production rates of V, showing its possible discovery at the maximal LHC energy with about 100 fb -1 of integrated luminosity.

  3. Electron anisotropy: A tool to discriminate dark matter in cosmic rays

    International Nuclear Information System (INIS)

    Borriello, Enrico; Maccione, Luca; Cuoco, Alessandro

    2012-01-01

    Indirect searches of particle Dark Matter (DM) with high energy Cosmic Rays (CR) are typically affected by large uncertainties. We show that, on the contrary, the DM intrinsic degree of anisotropy in the arrival directions of high energy CR electrons and positrons (CRE) is basically model independent and offers a straightforward criterion to discriminate among CRE from DM or from local discrete sources, like e.g. pulsars. In particular, in absence of the latter, DM sets the maximum degree of total anisotropy. As a consequence, if a larger anisotropy is detected, this would constitute an unambiguous evidence for the presence of astrophysical local discrete CRE sources. The Fermi-LAT will be able to probe such scenarios in the next years.

  4. Global interpretation of direct Dark Matter searches after CDMS-II results

    International Nuclear Information System (INIS)

    Kopp, Joachim; Schwetz, Thomas; Zupan, Jure

    2010-01-01

    We perform a global fit to data from Dark Matter (DM) direct detection experiments, including the recent CDMS-II results. We discuss possible interpretations of the DAMA annual modulation signal in terms of spin-independent and spin-dependent DM-nucleus interactions, both for elastic and inelastic scattering. We find that for the spin-dependent inelastic scattering off protons a good fit to all data is obtained. We present a simple toy model realizing such a scenario. In all the remaining cases the DAMA allowed regions are disfavored by other experiments or suffer from severe fine tuning of DM parameters with respect to the galactic escape velocity. Finally, we also entertain the possibility that the two events observed in CDMS-II are an actual signal of elastic DM scattering, and we compare the resulting CDMS-II allowed regions to the exclusion limits from other experiments

  5. Exploring fermionic dark matter via Higgs boson precision measurements at the Circular Electron Positron Collider

    Science.gov (United States)

    Xiang, Qian-Fei; Bi, Xiao-Jun; Yin, Peng-Fei; Yu, Zhao-Huan

    2018-03-01

    We study the impact of fermionic dark matter (DM) on projected Higgs precision measurements at the Circular Electron Positron Collider (CEPC), including the one-loop effects on the e+e-→Z h cross section and the Higgs boson diphoton decay, as well as the tree-level effects on the Higgs boson invisible decay. As illuminating examples, we discuss two UV-complete DM models, whose dark sector contains electroweak multiplets that interact with the Higgs boson via Yukawa couplings. The CEPC sensitivity to these models and current constraints from DM detection and collider experiments are investigated. We find that there exist some parameter regions where the Higgs measurements at the CEPC will be complementary to current DM searches.

  6. Can annihilating dark matter be lighter than a few GeVs?

    International Nuclear Information System (INIS)

    Boehm, C; Ensslin, T A; Silk, J

    2004-01-01

    We estimate the gamma-ray fluxes from the residual annihilations of dark matter (DM) particles having a mass m dm from [MeV, O(10) GeV] (a possible solution to the DM issue provided they have a new kind of interactions and no significant coupling to the Z) and compare them to observations. We find that particles lighter than O(100 MeV) can be viable DM candidates provided their dominant annihilation cross section is S-wave suppressed so as to satisfy the gamma-ray constraints. A similar conclusion is obtained for particles lighter than O(10) GeV from the study of radio fluxes, assuming a NFW profile and that they mainly annihilate into electrons

  7. Beyond effective field theory for dark matter searches at the LHC

    International Nuclear Information System (INIS)

    Buchmueller, O.; Dolan, Matthew J.; McCabe, Christopher

    2014-01-01

    We study the validity of effective field theory (EFT) interpretations of monojet searches for dark matter at the LHC for vector and axial-vector interactions. We show that the EFT approach is valid when the mediator has mass m med greater than 2.5 TeV. We find that the current limits on the contact interaction scale Λ in the EFT apply to theories that are perturbative for dark matter mass m DM <800 GeV. However, for all values of m DM in these theories, the mediator width is larger than the mass, so that a particle-like interpretation of the mediator is doubtful. Furthermore, consistency with the thermal relic density occurs only for 170≲m DM ≲510 GeV. For lighter mediator masses, the EFT limit either under-estimates the true limit (because the process is resonantly enhanced) or over-estimates it (because the missing energy distribution is too soft). We give some ‘rules of thumb’ that can be used to estimate the limit on Λ (to an accuracy of ∼50%) for any m DM and m med from knowledge of the EFT limit. We also compare the relative sensitivities of monojet and dark matter direct detection searches finding that both dominate in different regions of the m DM – m med plane. Comparing only the EFT limit with direct searches is misleading and can lead to incorrect conclusions about the relative sensitivity of the two search approaches

  8. Interaction of radiation with matter

    CERN Document Server

    Nikjoo, Hooshang; Emfietzoglou, Dimitris

    2012-01-01

    Written for students approaching the subject for the first time, this text provides a solid grounding in the physics of the interactions of photons and particles with matter, which is the basis of radiological physics and radiation dosimetry. The authors first present the relevant atomic physics and then describe the interactions, emphasizing practical applications in health/medical physics and radiation biology. They cover such important topics as microdosimetry, interaction of photons with matter, electron energy loss, and dielectric response. Each chapter includes exercises and a summary.

  9. CTX Correlation to Disease Duration and Adiponectin in Egyptian Children with T1DM/ Korelacija između CTX-a i trajanja bolesti i adiponektina kod egipatske dece sa T1DM

    Directory of Open Access Journals (Sweden)

    Hashim Amel A.

    2016-01-01

    Full Text Available Uvod: U ovoj studiji istraživali smo odnos između adiponektina i markera koštanih promena kod egipatske dece i ado­lescenata sa T1DM, uticaj trajanja bolesti na ove markere, kao i potencijalne korelacije između adiponektina i ko­štanih markera kod ovih pacijenata.

  10. The biological basis of radiotherapy

    International Nuclear Information System (INIS)

    Steel, G.G.; Adams, G.E.; Horwich, A.

    1989-01-01

    The focus of this book is the biological basis of radiotherapy. The papers presented include: Temporal stages of radiation action:free radical processes; The molecular basis of radiosensitivity; and Radiation damage to early-reacting normal tissue

  11. SEARCH FOR DARK MATTER ANNIHILATION SIGNALS FROM THE FORNAX GALAXY CLUSTER WITH H.E.S.S

    Energy Technology Data Exchange (ETDEWEB)

    Abramowski, A. [Institut fuer Experimentalphysik, Universitaet Hamburg, Luruper Chaussee 149, D 22761 Hamburg (Germany); Acero, F. [Laboratoire de Physique Theorique et Astroparticules, Universite Montpellier 2, CNRS/IN2P3, CC 70, Place Eugene Bataillon, F-34095 Montpellier Cedex 5 (France); Aharonian, F.; Bernloehr, K.; Bochow, A. [Max-Planck-Institut fuer Kernphysik, P.O. Box 103980, D 69029 Heidelberg (Germany); Akhperjanian, A. G. [National Academy of Sciences of the Republic of Armenia, Yerevan (Armenia); Anton, G.; Balzer, A.; Brucker, J. [Physikalisches Institut, Universitaet Erlangen-Nuernberg, Erwin-Rommel-Str. 1, D 91058 Erlangen (Germany); Barnacka, A. [Nicolaus Copernicus Astronomical Center, ul. Bartycka 18, 00-716 Warsaw (Poland); Barres de Almeida, U. [Department of Physics, University of Durham, South Road, Durham DH1 3LE (United Kingdom); Becherini, Y. [Astroparticule et Cosmologie (APC), CNRS, Universite Paris 7 Denis Diderot, 10, rue Alice Domon et Leonie Duquet, F-75205 Paris Cedex 13 (France); Becker, J. [Institut fuer Theoretische Physik, Lehrstuhl IV: Weltraum und Astrophysik, Ruhr-Universitaet Bochum, D 44780 Bochum (Germany); Behera, B. [Landessternwarte, Universitaet Heidelberg, Koenigstuhl, D 69117 Heidelberg (Germany); Birsin, E. [Institut fuer Physik, Humboldt-Universitaet zu Berlin, Newtonstr. 15, D 12489 Berlin (Germany); Biteau, J.; Brun, F. [Laboratoire Leprince-Ringuet, Ecole Polytechnique, CNRS/IN2P3, F-91128 Palaiseau (France); Boisson, C. [LUTH, Observatoire de Paris, CNRS, Universite Paris Diderot, 5 Place Jules Janssen, 92190 Meudon (France); Bolmont, J. [LPNHE, Universite Pierre et Marie Curie Paris 6, Universite Denis Diderot Paris 7, CNRS/IN2P3, 4 Place Jussieu, F-75252, Paris Cedex 5 (France); Bordas, P., E-mail: bjoern.opitz@desy.de [Institut fuer Astronomie und Astrophysik, Universitaet Tuebingen, Sand 1, D 72076 Tuebingen (Germany); Collaboration: H.E.S.S. Collaboration; and others

    2012-05-10

    The Fornax galaxy cluster was observed with the High Energy Stereoscopic System for a total live time of 14.5 hr, searching for very high energy (VHE; E > 100GeV) {gamma}-rays from dark matter (DM) annihilation. No significant signal was found in searches for point-like and extended emissions. Using several models of the DM density distribution, upper limits on the DM velocity-weighted annihilation cross-section ({sigma}v) as a function of the DM particle mass are derived. Constraints are derived for different DM particle models, such as those arising from Kaluza-Klein and supersymmetric models. Various annihilation final states are considered. Possible enhancements of the DM annihilation {gamma}-ray flux, due to DM substructures of the DM host halo, or from the Sommerfeld effect, are studied. Additional {gamma}-ray contributions from internal bremsstrahlung and inverse Compton radiation are also discussed. For a DM particle mass of 1 TeV, the exclusion limits at 95% of confidence level reach values of ({sigma}v){sup 95%C.L.} {approx} 10{sup -23} cm{sup 3} s{sup -1}, depending on the DM particle model and halo properties. Additional contribution from DM substructures can improve the upper limits on ({sigma}v) by more than two orders of magnitude. At masses around 4.5 TeV, the enhancement by substructures and the Sommerfeld resonance effect results in a velocity-weighted annihilation cross-section upper limit at the level of ({sigma}v){sup 95%C.L.} {approx}10{sup -26} cm{sup 3} s{sup -1}.

  12. SEARCH FOR DARK MATTER ANNIHILATION SIGNALS FROM THE FORNAX GALAXY CLUSTER WITH H.E.S.S

    International Nuclear Information System (INIS)

    Abramowski, A.; Acero, F.; Aharonian, F.; Bernlöhr, K.; Bochow, A.; Akhperjanian, A. G.; Anton, G.; Balzer, A.; Brucker, J.; Barnacka, A.; Barres de Almeida, U.; Becherini, Y.; Becker, J.; Behera, B.; Birsin, E.; Biteau, J.; Brun, F.; Boisson, C.; Bolmont, J.; Bordas, P.

    2012-01-01

    The Fornax galaxy cluster was observed with the High Energy Stereoscopic System for a total live time of 14.5 hr, searching for very high energy (VHE; E > 100GeV) γ-rays from dark matter (DM) annihilation. No significant signal was found in searches for point-like and extended emissions. Using several models of the DM density distribution, upper limits on the DM velocity-weighted annihilation cross-section (σv) as a function of the DM particle mass are derived. Constraints are derived for different DM particle models, such as those arising from Kaluza-Klein and supersymmetric models. Various annihilation final states are considered. Possible enhancements of the DM annihilation γ-ray flux, due to DM substructures of the DM host halo, or from the Sommerfeld effect, are studied. Additional γ-ray contributions from internal bremsstrahlung and inverse Compton radiation are also discussed. For a DM particle mass of 1 TeV, the exclusion limits at 95% of confidence level reach values of (σv) 95%C.L. ∼ 10 –23 cm 3 s –1 , depending on the DM particle model and halo properties. Additional contribution from DM substructures can improve the upper limits on (σv) by more than two orders of magnitude. At masses around 4.5 TeV, the enhancement by substructures and the Sommerfeld resonance effect results in a velocity-weighted annihilation cross-section upper limit at the level of (σv) 95%C.L. ∼10 –26 cm 3 s –1 .

  13. Media Matter

    Directory of Open Access Journals (Sweden)

    Holger Pötzsch

    2017-02-01

    Full Text Available The present contribution maps materialist advances in media studies. Based on the assumption that matter and materiality constitute significant aspects of communication processes and practices, I introduce four fields of inquiry - technology, political economy, ecology, and the body - and argue that these perspectives enable a more comprehensive understanding of the implications of contemporary technologically afforded forms of interaction. The article shows how each perspective can balance apologetic and apocalyptic approaches to the impact of in particular digital technologies, before it demonstrates the applicability of an integrated framework with reference to the techno-politics of NSA surveillance and the counter-practices of WikiLeaks.

  14. Play Matters

    DEFF Research Database (Denmark)

    Sicart (Vila), Miguel Angel

    ? In Play Matters, Miguel Sicart argues that to play is to be in the world; playing is a form of understanding what surrounds us and a way of engaging with others. Play goes beyond games; it is a mode of being human. We play games, but we also play with toys, on playgrounds, with technologies and design......, but not necessarily fun. Play can be dangerous, addictive, and destructive. Along the way, Sicart considers playfulness, the capacity to use play outside the context of play; toys, the materialization of play--instruments but also play pals; playgrounds, play spaces that enable all kinds of play; beauty...

  15. Dark Matter's secret liaisons: phenomenology of a dark U(1) sector with bound states

    Energy Technology Data Exchange (ETDEWEB)

    Cirelli, Marco; Petraki, Kalliopi; Sala, Filippo [Laboratoire de Physique Théorique et Hautes Energies (LPTHE), UMR 7589 CNRS and UPMC, 4 Place Jussieu, F-75252, Paris (France); Panci, Paolo [CERN Theoretical Physics Department, CERN, Case C01600, CH-1211 Genève (Switzerland); Taoso, Marco, E-mail: marco.cirelli@gmail.com, E-mail: paolo.panci@cern.ch, E-mail: kpetraki@lpthe.jussieu.fr, E-mail: filo.sala@gmail.com, E-mail: m.taoso@csic.es [Instituto de Física Teórica (IFT) UAM/CSIC, calle Nicolás Cabrera 13-15, 28049 Cantoblanco, Madrid (Spain)

    2017-05-01

    Dark matter (DM) charged under a dark U(1) force appears in many extensions of the Standard Model, and has been invoked to explain anomalies in cosmic-ray data, as well as a self-interacting DM candidate. In this paper, we perform a comprehensive phenomenological analysis of such a model, assuming that the DM abundance arises from the thermal freeze-out of the dark interactions. We include, for the first time, bound-state effects both in the DM production and in the indirect detection signals, and quantify their importance for FERMI, AMS-02, and CMB experiments. We find that DM in the mass range 1 GeV to 100 TeV, annihilating into dark photons of MeV to GeV mass, is in conflict with observations. Instead, DM annihilation into heavier dark photons is viable. We point out that the late decays of multi-GeV dark photons can produce significant entropy and thus dilute the DM density. This can lower considerably the dark coupling needed to obtain the DM abundance, and in turn relax the existing constraints.

  16. Model-independent implications of the e±, p-bar cosmic ray spectra on properties of Dark Matter

    International Nuclear Information System (INIS)

    Cirelli, M.; Kadastik, M.; Raidal, M.; Strumia, A.

    2009-01-01

    Taking into account spins, we classify all two-body non-relativistic Dark Matter annihilation channels to the allowed polarization states of Standard Model particles, computing the energy spectra of the stable final-state particles relevant for indirect DM detection. We study the DM masses, annihilation channels and cross sections that can reproduce the PAMELA indications of an e + excess consistently with the PAMELA p-bar data and the ATIC/PPB-BETS e + +e - data. From the PAMELA data alone, two solutions emerge: (i) either the DM particles that annihilate into W,Z,h must be heavier than about 10 TeV or (ii) the DM must annihilate only into leptons. Thus in both cases a DM particle compatible with the PAMELA excess seems to have quite unexpected properties. The solution (ii) implies a peak in the e + +e - energy spectrum, which, indeed, seems to appear in the ATIC/PPB-BETS data around 700 GeV. If upcoming data from ATIC-4 and GLAST confirm this feature, this would point to a O(1) TeV DM annihilating only into leptons. Otherwise the solution (i) would be favored. We comment on the implications of these results for DM models, direct DM detection and colliders as well as on the possibility of an astrophysical origin of the excess

  17. Explanation of the 511 keV line. Cascade annihilating dark matter with the {sup 8}Be anomaly

    Energy Technology Data Exchange (ETDEWEB)

    Jia, Lian-Bao [Southwest University of Science and Technology, School of Science, Mianyang (China)

    2018-02-15

    A possible dark matter (DM) explanation about the long-standing issue of the Galactic 511 keV line is explored in this paper. For DM cascade annihilations of concern, a DM pair π{sub d}{sup +}π{sub d}{sup -} annihilates into unstable π{sub d}{sup 0}π{sub d}{sup 0}, and π{sub d}{sup 0} decays into e{sup +}e{sup -} with new interactions suggested by the {sup 8}Be anomaly. Considering the constraints from the effective neutrino number N{sub eff} and the 511 keV gamma-ray emission, a range of DM is obtained, 11.6 DM annihilation cross section today is about 3.3 x 10{sup -29} cm{sup 3} s{sup -1}, which can give an explanation about the 511 keV line. The MeV scale DM may be searched by the DM-electron scattering, and the upper limit set by the CMB s-wave annihilation is derived in DM direct detections. (orig.)

  18. [Dry matter intake of South American camelids and its effects on the composition of feed rations].

    Science.gov (United States)

    Stölzl, Anna Maria; Lambertz, Christian; Moors, Eva; Stiehl, Jennifer; Gauly, Matthias

    2014-01-01

    The number of South American camelids (SAC) is increasing in Germany since decades. Due to a lack of scientifically based publications the knowledge about feeding SACs is still poor. Therefore, the aim of this study was to estimate the dry matter intake (DMI) of SACs as a basis for calculations of feed rations. Previous studies proposed a DMI of up to 3% of the body weight (BW) (Vaughan und Gauly, 2011). In the present study, eight llamas (Llama glama) were allocated to two groups of four animals each. The two groups were fed with hay of different qualities over a total period often weeks, which was divided into two runs of five weeks each. During the first run, group 1 was fed with hay 1 (15.1% crude protein; 8.5% crude ash; 3.1% crude fat; 52.6% NDF per kg DM) and group 2 with hay 2 (6.6% crude protein; 6.2% crude ash; 2.1% crude fat; 64.3% NDF per kg DM). After five weeks the groups were changed and group 1 received hay 2 and group 2 received hay 1. BW was measured at the start and end of each run (week zero, five and ten). The hay quality affected the DMI, but the animals did not compensate a lower feed quality with an increased DMI. The total DMI was 1.26% and 0.89% of the BW for hay 1 and hay 2, respectively, which was lower than expected in both groups. In conclusion, calculations of feed rations for SACs should be adjusted to the present findings of a lower DMI capability.

  19. Dark matter indirect detection with charged cosmic rays

    International Nuclear Information System (INIS)

    Giesen, Gaelle

    2015-01-01

    Overwhelming evidence for the existence of Dark Matter (DM), in the form of an unknown particle filling the galactic halos, originates from many observations in astrophysics and cosmology: its gravitational effects are apparent on galactic rotations, in galaxy clusters and in shaping the large scale structure of the Universe. On the other hand, a non-gravitational manifestation of its presence is yet to be unveiled. One of the most promising techniques is the one of indirect detection, aimed at identifying excesses in cosmic ray fluxes which could possibly be produced by DM annihilations or decays in the Milky Way halo. The current experimental efforts mainly focus in the GeV to TeV energy range, which is also where signals from WIMPs (Weakly Interacting Massive Particles) are expected. Focussing on charged cosmic rays, in particular antiprotons, electrons and positrons, as well as their secondary emissions, an analysis of current and foreseen cosmic ray measurements and improvements on astrophysical models are presented. Antiproton data from PAMELA imposes constraints on annihilating and decaying DM which are similar to (or even slightly stronger than) the most stringent bounds from gamma ray experiments, even when kinetic energies below 10 GeV are discarded. However, choosing different sets of astrophysical parameters, in the form of propagation models and halo profiles, allows the constraints to span over one or two orders of magnitude. In order to exploit fully the power of antiprotons to constrain or discover DM, effects which were previously perceived as sub-leading turn out to be relevant especially for the analysis of the newly released AMS-02 data. In fact, including energy losses, diffusive re-acceleration and solar modulation can somewhat modify the current bounds, even at large DM masses. A wrong interpretation of the data may arise if they are not taken into account. Finally, using the updated proton and helium fluxes just released by the AMS-02

  20. Molecular Basis of Circadian Photoreception

    Science.gov (United States)

    2006-06-30

    267, 16237-16243. Murakami, D.M., Miller, J.D., Fuller, C.A., 1989. The retinohypothalamic tract in the cat: retinal ganglion cell morphology and...Photochem Photobiol B 13, 5-17. Pickard, G.E., 1980. Morphological characteristics of retinal ganglion cells projecting to the suprachiasmatic nucleus: a...from archaea to humans. Annu Rev Cell Dev Biol 16, 365-392. Takahashi, J.S., DeCoursey, P.J., Bauman, L., Menaker, M., 1984. Spectral sensitivity

  1. Dark matter direct detection with non-Maxwellian velocity structure

    International Nuclear Information System (INIS)

    Kuhlen, Michael; Weiner, Neal; Diemand, Jürg; Moore, Ben; Potter, Doug; Stadel, Joachim; Madau, Piero; Zemp, Marcel

    2010-01-01

    The velocity distribution function of dark matter particles is expected to show significant departures from a Maxwell-Boltzmann distribution. This can have profound effects on the predicted dark matter - nucleon scattering rates in direct detection experiments, especially for dark matter models in which the scattering is sensitive to the high velocity tail of the distribution, such as inelastic dark matter (iDM) or light (few GeV) dark matter (LDM), and for experiments that require high energy recoil events, such as many directionally sensitive experiments. Here we determine the velocity distribution functions from two of the highest resolution numerical simulations of Galactic dark matter structure (Via Lactea II and GHALO), and study the effects for these scenarios. For directional detection, we find that the observed departures from Maxwell-Boltzmann increase the contrast of the signal and change the typical direction of incoming DM particles. For iDM, the expected signals at direct detection experiments are changed dramatically: the annual modulation can be enhanced by more than a factor two, and the relative rates of DAMA compared to CDMS can change by an order of magnitude, while those compared to CRESST can change by a factor of two. The spectrum of the signal can also change dramatically, with many features arising due to substructure. For LDM the spectral effects are smaller, but changes do arise that improve the compatibility with existing experiments. We find that the phase of the modulation can depend upon energy, which would help discriminate against background should it be found

  2. Asupan vitamin C berhubungan dengan kadar glukosa darah pada pasien rawat jalan DM tipe 2

    Directory of Open Access Journals (Sweden)

    Riya Purwaningtyastuti

    2018-01-01

    Full Text Available ABSTRACKBackground: High sugar levels in people with diabetes mellitus causes changes in the body. One of its detrimental process called oxidation reaction that causes the increased formation of harmful substances called free radicals. Antioxidant vitamin A, C, and E helpful to reduce oxidative damage in people with diabetes mellitus and prevent complications. Objectives: The know relationship intake antioxidant with blood glocuse level outpatient type 2 diabetes mellitus in RSUD Panembahan Senopati Bantul Yogyakarta. Methods: This study was observasional with of cross sectional. The subjects in this study were outpatients with diabetes mellitus type 2 with sampels of 89 respondents. Purposive sampling technique. Data consumption pattern of antioxidant, used semi quantitative food frequency (SQFFQ laboratories to examination and blood glucose levels. Data analysis used Fisher’s Exact Test. Results: There is significant association between vitamin C intake with blood sugar levels in patients diabetes mellitus the value of p = 0.004. The existence of a no signifi cant association between vitamin E intake with blood sugar levels in patients diabetes mellitus the value of p = 0.073 and there is no signifi cant association between vitamin A intake with blood sugar levels in patients diabetes mellitus the value of p = 0.252. Conclusion: There is a relationship between vitamin C intake with blood sugar levels, while the intake of vitamin A and E are not related to blood sugar levels KEYWORDS: type 2 diabetes mellitus, blood glucose level, vitamin C intake, vitamin A intake, vitamin E intake. ABSTRAK Latar Belakang : Kadar glukosa yang tinggi pada penderita kencing manis/DM menyebabkan berbagai perubahan di dalam tubuh. Salah satu proses merugikan dinamakan reaksi oksidasi yang menyebabkan peningkatan pembentukan zat berbahaya yang disebut radikal bebas. Antioksidan vitamin A,C dan E bermanfaat dapat menurunkan kadar glukosa darah. Tujuan: Untuk

  3. A Widespread, Clumpy Starburst in the Isolated Ongoing Dwarf Galaxy Merger dm1647+21

    Energy Technology Data Exchange (ETDEWEB)

    Privon, G. C. [Instituto de Astrofśica, Facultad de Física, Pontificia Universidad Católica de Chile, Casilla 306, Santiago 22 (Chile); Stierwalt, S.; Johnson, K. E.; Kallivayalil, N.; Liss, S. [Department of Astronomy, University of Virginia, 530 McCormick Road, Charlottesville, VA 22904 (United States); Patton, D. R. [Department of Physics and Astronomy, Trent University, 1600 West Bank Drive, Peterborough, ON K9L 0G2 (Canada); Besla, G. [Department of Astronomy, University of Arizona, 933 North Cherry Avenue, Tucson, AZ 85721 (United States); Pearson, S.; Putman, M., E-mail: gprivon@astro.puc.cl [Department of Astronomy, Columbia University, 550 West 120th Street, New York, NY 10027 (United States); Collaboration: TiNy Titans

    2017-09-01

    Interactions between pairs of isolated dwarf galaxies provide a critical window into low-mass hierarchical, gas-dominated galaxy assembly and the build-up of stellar mass in low-metallicity systems. We present the first Very Large Telescope/Multi Unit Spectroscopic Explorer (VLT/MUSE) optical integral field unit (IFU) observations of the interacting dwarf pair dm1647+21 selected from the TiNy Titans survey. The H α emission is widespread and corresponds to a total unobscured star formation rate (SFR) of 0.44 M {sub ⊙} yr{sup −1}, which is 2.7 times higher than the SFR inferred from Sloan Digital Sky Survey (SDSS) data. The implied specific SFR (sSFR) for the system is elevated by more than an order of magnitude above non-interacting dwarfs in the same mass range. This increase is dominated by the lower-mass galaxy, which has a sSFR enhancement of >50. Examining the spatially resolved maps of classic optical line diagnostics, we find that the interstellar medium (ISM) excitation can be fully explained by star formation. The velocity field of the ionized gas is not consistent with simple rotation. Dynamical simulations indicate that the irregular velocity field and the stellar structure is consistent with the identification of this system as an ongoing interaction between two dwarf galaxies. The widespread, clumpy enhancements in the star formation in this system point to important differences in the effect of mergers on dwarf galaxies, compared to massive galaxies; rather than the funneling of gas to the nucleus and giving rise to a nuclear starburst, starbursts in low-mass galaxy mergers may be triggered by large-scale ISM compression, and thus may be more distributed.

  4. Crystal structure analysis of C-phycoerythrin from marine cyanobacterium Phormidium sp. A09DM.

    Science.gov (United States)

    Kumar, Vinay; Sonani, Ravi R; Sharma, Mahima; Gupta, Gagan D; Madamwar, Datta

    2016-07-01

    The role of unique sequence features of C-phycoerythrin, isolated from Phormidium sp. A09DM, has been investigated by crystallographic studies. Two conserved indels (i.e. inserts or deletions) are found in the β-subunit of Phormidium phycoerythrin that are distinctive characteristics of large number of cyanobacterial sequences. The identified signatures are a two-residue deletion from position 21 and a nine-residue insertion at position 146. Crystals of Phormidium phycoerythrin were obtained at pH values of 5 and 8.5, and structures have been resolved to high precision at 1.95 and 2.1 Å resolution, respectively. In both the structures, heterodimers of α- and β- subunits assemble as hexamers. The 7-residue insertion at position 146 significantly reduces solvent exposure of π-conjugated A-C rings of a phycoerythrobilin (PEB) chromophore, and can influence energy absorption and energy transfer characteristics. The structural analyses (with 12-fold redundancy) suggest that protein micro-environment alone dictates the conformation of bound chromophores. The low- and high-energy absorbing chromophores are identified based on A-B ring coplanarity. The spatial distribution of these is found to be similar to that observed in R-phycoerythrin, suggesting the direction of energy transfer from outer-surface of hexamer to inner-hollow cavity in the Phormidium protein. The crystal structures also reveal that a commonly observed Hydrogen-bonding network in phycobiliproteins, involving chromophore bound to α-subunit and amino acid at position 73 of β-subunit, may not be essential for structural and functional integrity of C-phycoerythrin orthologs. In solution, the protein displays slight red shift and decrease in fluorescence emission at acidic pH. The mechanism for which may be static and correlates with the proximity of +ve electric field of Arg148 to the C-ring of a PEB chromophore.

  5. Characterization and biocompatibility of glucan: a safe food additive from probiotic Lactobacillus plantarum DM5.

    Science.gov (United States)

    Das, Deeplina; Goyal, Arun

    2014-03-15

    Exopolysaccharide produced by lactic acid bacteria are the subject of an increasing number of studies for their potential applications in the food industry as stabilizing, bio-thickening and immunostimulating agents. In this regard, the authors isolated an exopolysaccharide producing probiotic lactic acid bacterium from fermented beverage Marcha of north eastern Himalayas. The isolate Lactobacillus plantarum DM5 showed extracellular glucansucrase activity of 0.48 U mg⁻¹ by synthesizing natural exopolysaccharide glucan (1.87 mg mL⁻¹) from sucrose. Zymogram analysis of purified enzyme confirms the presence of glucosyltransferase of approximately 148 kDa with optimal activity of 18.7 U mg⁻¹ at 30 °C and pH 5.4. The exopolysaccharide was purified by gel permeation chromatography and had an average molecular weight of 1.11 × 10⁶ Da. Acid hydrolysis and structural characterization of exopolysaccharide revealed that it was composed of d-glucose residues, containing 86.5% of α-(1→6) and 13.5% of α-(1→3) linkages. Rheological study exhibited a shear thinning effect of glucan appropriate for food additives. A cytotoxicity test of glucan on human embryonic kidney 293 (HEK 293) and human cervical cancer (HeLa) cell lines revealed its nontoxic biocompatible nature. This is the first report on the structure and biocompatibility of homopolysaccharide α-D-glucan (dextran) from probiotic Lactobacillus plantarum strain and its unique physical and rheological properties that facilitate its application in the food industry as viscosifying and gelling agent. © 2013 Society of Chemical Industry.

  6. Frequency of retinopathy in newly diagnosed patients of type 2 diabetes mellitus (dm)

    International Nuclear Information System (INIS)

    Khan, K.A.; Kamran, S.M.; Qureshi, M.N.

    2015-01-01

    This study was to determine the frequency of retinopathy in newly diagnosed type-II Diabetics. Study Design: Cross sectional descriptive study. Place and Duration of Study: It was conducted at Department of medicine, Military Hospital (MH), Rawalpindi from 1st Jan 2012 to 30 Jun 2012. Material and Methods: We included 200 patients of type-II DM from both genders diagnosed in last 03 months from both outdoor and indoor departments in the age range of 40 to 70 years by consecutive sampling. All patients having co morbidities affecting retina were excluded. Informed written consent was taken before enrollment. Formal approval of the study was taken from hospital ethical committee. Ocular Fundoscopy was performed with WelchAllyn Ophthalmoscope (REF 11470) as per standard protocols and both eyes were examined. The grade of DR (diabetic retinopathy) awarded as per highest changes in any of the two eyes. All tests were carried by a single person to avoid inter-observer variations. Findings of ocular fundoscopy were confirmed by ophthalmologist. All data was analyzed by using SPSS version 11. Results: Out of 200 subjects 63.5% were male and 36.5% were female. Age ranged from 40 to 70 years with mean age of 51.05+ 6.910 years. 29 (14.5%) subjects had Diabetic retinopathy. Out of 29 patients, 24 (82.8%) had preproliferative and 5 (17.2%) had proliferative diabetic retinopathy. Conclusion: A significant proportion of diabetic patients have retinopathy at the time of diagnosis of their disease which is more common in males and with increasing age. It is recommended to thoroughly screen the newly diagnosed diabetics for early detection of diabetic retinopathy and its management involving early referral to eye specialist. (author)

  7. Alcohol Consumption Is a Risk Factor for Lower Extremity Arterial Disease in Chinese Patients with T2DM

    Directory of Open Access Journals (Sweden)

    Shanshan Yang

    2017-01-01

    Full Text Available Objective. To investigate the relationship between alcohol consumption and diabetic lower extremity arterial disease (LEAD in hospitalized patients with type 2 diabetes mellitus (T2DM. Methods. We evaluated 138 hospitalized patients with T2DM who consumed alcohol and 833 who did not. We used propensity score matching to reduce the confounding bias between groups. Additionally, a logistic regression analysis was performed with the matched data to evaluate the LEAD risk. Results. In total, 119 pairs of patients who did and did not consume alcohol were matched. According to the logistic regression analysis, patients who consumed >8 U of alcohol/day had a higher risk of LEAD (odds ratio (OR: 6.35, 95% confidence interval (CI: 1.78–22.65 than patients who did not consume alcohol. Additionally, after adjusting for age, gender, region, occupation, smoking status, body mass index, weight change, and duration of diabetes, the OR of peripheral artery disease after >20 years of alcohol consumption was 3.48 (95% CI: 1.09–11.15. Furthermore, we observed a significant dose-response relationship between alcohol consumption and LEAD. Conclusions. Alcohol consumption may be a risk factor of LEAD in patients with T2DM. Patients with T2DM should be advised to stop drinking, to prevent the onset of LEAD.

  8. Association of TCF7L2 gene polymorphisms with T2DM in the population of Hyderabad, India.

    Directory of Open Access Journals (Sweden)

    Kommoju Uma Jyothi

    Full Text Available We attempt to evaluate the nature of association of TCF7L2 gene variants with T2DM, for the first time in the population of Hyderabad, which is considered to be diabetic capital of India. It is a case-control study of the three SNPs of TCF7L2, rs7903146, rs12255372 and rs11196205, genotyped on Sequenom Massarray platform, in a sample of 758 patients and 621 controls. The risk allele frequency of the three SNPs was found to be significantly higher in the T2DM cases than controls, implicating susceptibility for diabetes (p<0.01. The greatest risk of developing the disease was conferred by rs7903146. Further, the logistic regression of genotypes of each SNP under log additive model, and the haplotypes constituted by at least one of the three risk alleles also show significantly greater risk of developing T2DM when compared to the wild type haplotype. Further, BMI and WHR emerge as significant covariates with confounding effects. The strong association of the TCF7L2 SNPs with T2DM is consistent with the findings among other Indian and Non-Indian populations, suggesting universal phenomena of its association across ethnic groups globally, both within and outside the Indian subcontinent, albeit the functional relevance of these SNPs needs yet to be established.

  9. Prescription Pattern of Antihypertensive Agents in T2DM Patients Visiting Tertiary Care Centre in North India

    Directory of Open Access Journals (Sweden)

    Ethiraj Dhanaraj

    2012-01-01

    Full Text Available Background. Hypertension management is of a paramount importance in diabetic patients for cardiovascular risk reduction. Aim. To evaluate prescribing pattern of antihypertensive in T2DM (type 2 diabetes patients and compare with existing recent guidelines. Methods. A cross-sectional study involving evaluation of all T2DM patients referred to endocrinology unit at tertiary care centre for hypertension, comorbid complications, and recording prescription. Utilization of 5 different antihypertensive drug classes was compared for all patients receiving 1, 2, 3, 4, or more drugs. Logistical regression was used to assess likelihood of prescription of drugs and/or therapy for specific conditions mentioned in the guidelines. Results. Out of 1358, T2DM enrolled patients 1186 (87% had hypertension (males 52%, females 48%. The median duration (IQ of hypertension diabetics was 4 (1–10 years. A total of 25% patients had controlled BP and 75% with uncontrolled blood pressure (13% isolated systolic hypertension, 6% isolated diastolic hypertension, and 55% both elevated. Overall, ACE inhibitors (ACEIs were prescribed the highest (59% followed by angiotensin receptor blockers (ARBs (52%, calcium channel blockers (CCBs (29%, diuretics (27%, and beta-blockers (14%. Overall, 55% of T2DM patients were on polytherapy, 41% on monotherapy, and 4% had no antihypertensive treatment. Polytherapy was more predominant with age, duration of diabetes, duration of hypertension, and comorbid complications. Conclusion. Although prescribing pattern of antihypertensive showed adherence to existing evidence-based guidelines, higher proportion of uncontrolled hypertensive patients was found.

  10. Plasma amino acid and metabolite signatures tracking diabetes progression in the UCD-T2DM rat model

    Science.gov (United States)

    Elevations of plasma concentrations of branched-chain amino acids (BCAAs) are observed in human insulin resistance and type 2 diabetes mellitus (T2DM); however, there has been some controversy with respect to the passive or causative nature of the BCAA phenotype. Using untargeted metabolomics, plasm...

  11. SOLAR CONSTRAINTS ON ASYMMETRIC DARK MATTER

    Energy Technology Data Exchange (ETDEWEB)

    Lopes, Ilidio [Centro Multidisciplinar de Astrofisica, Instituto Superior Tecnico, Universidade Tecnica de Lisboa, Av. Rovisco Pais, 1049-001 Lisboa (Portugal); Silk, Joseph, E-mail: ilidio.lopes@ist.utl.pt, E-mail: silk@astro.ox.ac.uk [Institut d' Astrophysique de Paris, F-75014 Paris (France)

    2012-10-01

    The dark matter content of the universe is likely to be a mixture of matter and antimatter, perhaps comparable to the measured asymmetric mixture of baryons and antibaryons. During the early stages of the universe, the dark matter particles are produced in a process similar to baryogenesis, and dark matter freezeout depends on the dark matter asymmetry and the annihilation cross section (s-wave and p-wave annihilation channels) of particles and antiparticles. In these {eta}-parameterized asymmetric dark matter ({eta}ADM) models, the dark matter particles have an annihilation cross section close to the weak interaction cross section, and a value of dark matter asymmetry {eta} close to the baryon asymmetry {eta}{sub B}. Furthermore, we assume that dark matter scattering of baryons, namely, the spin-independent scattering cross section, is of the same order as the range of values suggested by several theoretical particle physics models used to explain the current unexplained events reported in the DAMA/LIBRA, CoGeNT, and CRESST experiments. Here, we constrain {eta}ADM by investigating the impact of such a type of dark matter on the evolution of the Sun, namely, the flux of solar neutrinos and helioseismology. We find that dark matter particles with a mass smaller than 15 GeV, a spin-independent scattering cross section on baryons of the order of a picobarn, and an {eta}-asymmetry with a value in the interval 10{sup -12}-10{sup -10}, would induce a change in solar neutrino fluxes in disagreement with current neutrino flux measurements. This result is also confirmed by helioseismology data. A natural consequence of this model is suppressed annihilation, thereby reducing the tension between indirect and direct dark matter detection experiments, but the model also allows a greatly enhanced annihilation cross section. All the cosmological {eta}ADM scenarios that we discuss have a relic dark matter density {Omega}h {sup 2} and baryon asymmetry {eta}{sub B} in agreement with

  12. SOLAR CONSTRAINTS ON ASYMMETRIC DARK MATTER

    International Nuclear Information System (INIS)

    Lopes, Ilídio; Silk, Joseph

    2012-01-01

    The dark matter content of the universe is likely to be a mixture of matter and antimatter, perhaps comparable to the measured asymmetric mixture of baryons and antibaryons. During the early stages of the universe, the dark matter particles are produced in a process similar to baryogenesis, and dark matter freezeout depends on the dark matter asymmetry and the annihilation cross section (s-wave and p-wave annihilation channels) of particles and antiparticles. In these η-parameterized asymmetric dark matter (ηADM) models, the dark matter particles have an annihilation cross section close to the weak interaction cross section, and a value of dark matter asymmetry η close to the baryon asymmetry η B . Furthermore, we assume that dark matter scattering of baryons, namely, the spin-independent scattering cross section, is of the same order as the range of values suggested by several theoretical particle physics models used to explain the current unexplained events reported in the DAMA/LIBRA, CoGeNT, and CRESST experiments. Here, we constrain ηADM by investigating the impact of such a type of dark matter on the evolution of the Sun, namely, the flux of solar neutrinos and helioseismology. We find that dark matter particles with a mass smaller than 15 GeV, a spin-independent scattering cross section on baryons of the order of a picobarn, and an η-asymmetry with a value in the interval 10 –12 -10 –10 , would induce a change in solar neutrino fluxes in disagreement with current neutrino flux measurements. This result is also confirmed by helioseismology data. A natural consequence of this model is suppressed annihilation, thereby reducing the tension between indirect and direct dark matter detection experiments, but the model also allows a greatly enhanced annihilation cross section. All the cosmological ηADM scenarios that we discuss have a relic dark matter density Ωh 2 and baryon asymmetry η B in agreement with the current WMAP measured values, Ω DM h 2 = 0

  13. Constraints on decaying Dark Matter from XMM-Newton observations of M31

    CERN Document Server

    Boyarsky, Alexey; Ruchayskiy, Oleg; Savchenko, Vladimir

    2007-01-01

    We derive constraints on parameters of the radiatively decaying Dark Matter (DM) particles, using XMM-Newton EPIC spectra of the Andromeda galaxy (M31). Using the observations of the outer (5'-13') parts of M31 we improve the existing constraints. For the case of sterile neutrino DM, combining our constraints with the latest computation of abundances of sterile neutrino in the Dodelson-Widrow (DW) scenario, we obtain the lower mass limit m_s 5.6 kev), we argue that the scenario in which all the DM is produced via DW mechanism is ruled out. We discuss however other production mechanisms and note that the sterile neutrino remains a viable candidate of Dark Matter, either warm or cold.

  14. DaMaSCUS-CRUST: Dark Matter Simulation Code for Underground Scatterings - Crust Edition

    Science.gov (United States)

    Emken, Timon; Kouvaris, Chris

    2018-03-01

    DaMaSCUS-CRUST determines the critical cross-section for strongly interacting DM for various direct detection experiments systematically and precisely using Monte Carlo simulations of DM trajectories inside the Earth's crust, atmosphere, or any kind of shielding. Above a critical dark matter-nucleus scattering cross section, any terrestrial direct detection experiment loses sensitivity to dark matter, since the Earth crust, atmosphere, and potential shielding layers start to block off the dark matter particles. This critical cross section is commonly determined by describing the average energy loss of the dark matter particles analytically. However, this treatment overestimates the stopping power of the Earth crust; therefore, the obtained bounds should be considered as conservative. DaMaSCUS-CRUST is a modified version of DaMaSCUS (ascl:1706.003) that accounts for shielding effects and returns a precise exclusion band.

  15. Expansive hematoma in delayed cerebral radiation necrosis in patients treated with T-DM1: a report of two cases

    International Nuclear Information System (INIS)

    Mitsuya, Koichi; Watanabe, Junichiro; Nakasu, Yoko; Hayashi, Nakamasa; Harada, Hideyuki; Ito, Ichiro

    2016-01-01

    Multiple new targeted agents have been developed for patients with human epidermal growth factor receptor type 2 (HER2) – positive breast cancer. Patients with HER2– positive breast cancer will develop brain metastases with greater incidence than patients with non-HER2 cancers, and many of them will undergo stereotactic radiosurgery (SRS) or other CNS radiotherapy. The interaction between radiation effects and new targeted agents is not well understood. We report two cases suggesting a novel adverse effect of T-DM1 (trastuzumab emtansine) on symptomatic enlargement of radiation necrosis (RN) after SRS. Two patients with HER2-positive breast cancer had received SRS for single brain metastasis more than 5-years ago. They had been heavily treated for HER2-positive metastatic breast cancer (trastuzumab and pacritaxel, lapatinib and capecitabine). They initiated T-DM1 therapy for progressive systematic disease 5.5 years after stereotactic irradiation, when a small RN was recognized on brain MR images of each patient. The RN lesions increased in size and became symptomatic during 13 or 14 months of T-DM1 treatment. The patients underwent surgical resection of the lesion. Pathological examination revealed necrosis, hematoma, granulation tissue and telangiectasia without neoplastic cells. A potential enhancement of RN by T-DM1 in the brain may be one of important adverse events associated with the use of T-DM1 for patients after SRS. These cases highlight the need of careful follow-up when combining new systemic targeted therapies and SRS for brain metastases

  16. Efficacy and safety of insulin pump treatment in adult T1DM patients--influence of age and social environment.

    Science.gov (United States)

    Grzanka, Małgorzata; Matejko, Bartłomiej; Cyganek, Katarzyna; Kozek, Elżbieta; Małecki, Maciej T; Klupa, Tomasz

    2012-01-01

    Continuous subcutaneous insulin infusion (CSII) via personal insulin pump is a valuable therapeutic tool in T1DM patients. However, adherence to recommended CSII-related behaviours may be of concern to young adults with intensive, variable daily activities (students, young professionals). The aim of this observational study was to estimate treatment outcomes in young adult patients with T1DM, and compare them with older individuals. Overall, 140 adults with T1DM on CSII were examined, divided into 2 subgroups: 77 patients younger than 26 years of age (mean 20.6 years) and 63 older subjects (mean 39.0). We compared the glycaemic control in both groups of T1DM subjects and analyzed treatment attitudes to identify potentially modifiable behaviours influencing the efficacy of the treatment. The younger individuals were characterized by significantly worse treatment outcomes, compared to the older ones: the mean HbA1c levels were 7.6 ± 1.3% and 6.9±1.3% (p=0.00001), while the mean glucose levels based on glucometer downloads were 161±33.6 mg/dL and 136±21.8 mg/dL (p=0.00001), respectively. The frequency of self-monitoring of blood glucose (SMBG) was lower in younger individuals (5.3±2.1 vs. 7.0±2.8 daily, p=0.0005, respectively); they were also less frequently used advanced pump functions, e.g. the bolus calculator (48% vs. 67% users, p=0.0014, respectively). The efficacy of CSII treatment observed in young T1DM adults was worse than in older patients. The reason for this phenomenon remains unclear, it may be due simply to age-dependend behaviours, to social environment, or both.

  17. An Integrative Review of Self-Efficacy Measurement Instruments in Youth with Type 1 Diabetes (T1DM)

    Science.gov (United States)

    Rasbach, Lisa; Jenkins, Carolyn; Laffel, Lori

    2014-01-01

    Purpose The purpose of this study is to assess the extant literature on instruments used to measure self-efficacy in youth with type 1 diabetes (T1DM) and their caregivers and to critically evaluate these measurements. Methods An integrative review (2003–2013) was conducted searching PsycINFO, Cumulative Index to Nursing and Allied Health Literature (CINAHL), and U.S. National Library of Medicine PubMed service (PubMed) databases using key words diabetes, type 1 diabetes, and self-efficacy. The authors reviewed the resulting294 references for inclusion criteria of (a) sample of youth with T1DM or sample of caregivers of youth with T1DM, (b) description of the self-efficacy instrument as primary research, and (c) the instrument measured self-efficacy specifically related to diabetes management. Forty-five articles out of the initial 294 met criteria. Results Of the 45 articles, 10 different self-efficacy instruments were identified. The primary theoretical framework used was Bandura’s social cognitive theory and model of self-efficacy. Most participants were white middle class T1DM youth. Evaluations to assess validity often were not reported; however, a majority of studies reported high internal consistency of the instruments. Conclusions Sample homogeneity could limit the applicability of results to certain patient populations. Further psychometric analysis, including validity assessments, should be conducted in more diverse samples. Development of valid and reliable instruments for measuring self-efficacy that are sensitive to change across a wider caregiver base over time is necessary. While this review examined reliable and valid instruments used in research, future opportunities include evaluation of measuring self-efficacy in T1DM youth exposed to recent advances in diabetes management technologies. PMID:25216655

  18. The 21 cm signal and the interplay between dark matter annihilations and astrophysical processes

    Energy Technology Data Exchange (ETDEWEB)

    Lopez-Honorez, Laura [Theoretische Natuurkunde, Vrije Universiteit Brussel and The International Solvay Institutes, Pleinlaan 2, B-1050 Brussels (Belgium); Mena, Olga; Moliné, Ángeles; Palomares-Ruiz, Sergio [Instituto de Física Corpuscular (IFIC), CSIC-Universitat de València, Apartado de Correos 22085, E-46071 Valencia (Spain); Vincent, Aaron C., E-mail: llopezho@vub.ac.be, E-mail: omena@ific.uv.es, E-mail: maria.moline@ist.utl.pt, E-mail: sergio.Palomares.Ruiz@ific.uv.es, E-mail: aaron.vincent@durham.ac.uk [Institute for Particle Physics Phenomenology (IPPP), Department of Physics, Durham University, Durham DH1 3LE (United Kingdom)

    2016-08-01

    Future dedicated radio interferometers, including HERA and SKA, are very promising tools that aim to study the epoch of reionization and beyond via measurements of the 21 cm signal from neutral hydrogen. Dark matter (DM) annihilations into charged particles change the thermal history of the Universe and, as a consequence, affect the 21 cm signal. Accurately predicting the effect of DM strongly relies on the modeling of annihilations inside halos. In this work, we use up-to-date computations of the energy deposition rates by the products from DM annihilations, a proper treatment of the contribution from DM annihilations in halos, as well as values of the annihilation cross section allowed by the most recent cosmological measurements from the Planck satellite. Given current uncertainties on the description of the astrophysical processes driving the epochs of reionization, X-ray heating and Lyman-α pumping, we find that disentangling DM signatures from purely astrophysical effects, related to early-time star formation processes or late-time galaxy X-ray emissions, will be a challenging task. We conclude that only annihilations of DM particles with masses of ∼100 MeV, could leave an unambiguous imprint on the 21 cm signal and, in particular, on the 21 cm power spectrum. This is in contrast to previous, more optimistic results in the literature, which have claimed that strong signatures might also be present even for much higher DM masses. Additional measurements of the 21 cm signal at different cosmic epochs will be crucial in order to break the strong parameter degeneracies between DM annihilations and astrophysical effects and undoubtedly single out a DM imprint for masses different from ∼100 MeV.

  19. Study on the inter-relationship among the changes of serum levels of leptin, insulin and glucagon in patients with DM2 complicated with hypertension

    International Nuclear Information System (INIS)

    Zeng Zhiwei; Yan Songqin; Tan Wei

    2006-01-01

    Objective: To investigate the inter-relationship among the changes of serum leptin, insulin and glucagon levels in patients with type 2 diabetes mellitus (DM2) complicated with hypertension. Methods: Serum leptin, insulin and glucagon levels were, measured with RIA in 30 DM2 patients complicated with hypertension, 30 DM2 patients without hypertension and 30 controls. Results: Serum levels of leptin, insulin and glucagon in all the DM2 patients were significantly higher than those in controls (P<0.01). In addition, the serum levels in DM2 patients with hypertension were significantly higher than those in DM2 patients without hypertension (P<0.05). These levels were positively correlated with the severity of hypertension. Conclusion: The role played by leptin and glucagon in the pathogenesis of type 2 diabetes mellitns should be furthur studied. (authors)

  20. "Non-cold" dark matter at small scales: a general approach

    Science.gov (United States)

    Murgia, R.; Merle, A.; Viel, M.; Totzauer, M.; Schneider, A.

    2017-11-01

    Structure formation at small cosmological scales provides an important frontier for dark matter (DM) research. Scenarios with small DM particle masses, large momenta or hidden interactions tend to suppress the gravitational clustering at small scales. The details of this suppression depend on the DM particle nature, allowing for a direct link between DM models and astrophysical observations. However, most of the astrophysical constraints obtained so far refer to a very specific shape of the power suppression, corresponding to thermal warm dark matter (WDM), i.e., candidates with a Fermi-Dirac or Bose-Einstein momentum distribution. In this work we introduce a new analytical fitting formula for the power spectrum, which is simple yet flexible enough to reproduce the clustering signal of large classes of non-thermal DM models, which are not at all adequately described by the oversimplified notion of WDM . We show that the formula is able to fully cover the parameter space of sterile neutrinos (whether resonantly produced or from particle decay), mixed cold and warm models, fuzzy dark matter, as well as other models suggested by effective theory of structure formation (ETHOS). Based on this fitting formula, we perform a large suite of N-body simulations and we extract important nonlinear statistics, such as the matter power spectrum and the halo mass function. Finally, we present first preliminary astrophysical constraints, based on linear theory, from both the number of Milky Way satellites and the Lyman-α forest. This paper is a first step towards a general and comprehensive modeling of small-scale departures from the standard cold DM model.

  1. Constraints on majoron dark matter from cosmic microwave background and astrophysical observations

    Energy Technology Data Exchange (ETDEWEB)

    Lattanzi, Massimiliano, E-mail: lattanzi@fe.infn.it [Dipartimento di Fisica e Science della Terra, Università di Ferrara and INFN, sezione di Ferrara, Polo Scientifico e Tecnologico - Edificio C Via Saragat, 1, I-44122 Ferrara Italy (Italy); Riemer-Sørensen, Signe [School of Mathematics and Physics, University of Queensland, St Lucia, Brisbane 4072, Queensland (Australia); Tórtola, Mariam; Valle, J.W.F. [AHEP Group, Instituto de Física Corpuscular – C.S.I.C./Universitat de València Campus de Paterna, Apt 22085, E-46071 València (Spain)

    2014-04-01

    The origin of dark matter and the generation of neutrino masses could be related if neutrino masses arise from the spontaneous violation of ungauged lepton number. In this case the associated Nambu–Goldstone boson, the majoron, could acquire a mass from non-perturbative gravitational effects and play the role of DM. Here we report our cosmological and astrophysical constraints on majoron dark matter coming from Cosmic Microwave Background (CMB) and a variety of X- and γ-ray observations.

  2. Constraints on majoron dark matter from cosmic microwave background and astrophysical observations

    International Nuclear Information System (INIS)

    Lattanzi, Massimiliano; Riemer-Sørensen, Signe; Tórtola, Mariam; Valle, J.W.F.

    2014-01-01

    The origin of dark matter and the generation of neutrino masses could be related if neutrino masses arise from the spontaneous violation of ungauged lepton number. In this case the associated Nambu–Goldstone boson, the majoron, could acquire a mass from non-perturbative gravitational effects and play the role of DM. Here we report our cosmological and astrophysical constraints on majoron dark matter coming from Cosmic Microwave Background (CMB) and a variety of X- and γ-ray observations

  3. Marginal Matter

    Science.gov (United States)

    van Hecke, Martin

    2013-03-01

    All around us, things are falling apart. The foam on our cappuccinos appears solid, but gentle stirring irreversibly changes its shape. Skin, a biological fiber network, is firm when you pinch it, but soft under light touch. Sand mimics a solid when we walk on the beach but a liquid when we pour it out of our shoes. Crucially, a marginal point separates the rigid or jammed state from the mechanical vacuum (freely flowing) state - at their marginal points, soft materials are neither solid nor liquid. Here I will show how the marginal point gives birth to a third sector of soft matter physics: intrinsically nonlinear mechanics. I will illustrate this with shock waves in weakly compressed granular media, the nonlinear rheology of foams, and the nonlinear mechanics of weakly connected elastic networks.

  4. On the Existence of Low-Mass Dark Matter and its Direct Detection

    Science.gov (United States)

    Bateman, James; McHardy, Ian; Merle, Alexander; Morris, Tim R.; Ulbricht, Hendrik

    2015-01-01

    Dark Matter (DM) is an elusive form of matter which has been postulated to explain astronomical observations through its gravitational effects on stars and galaxies, gravitational lensing of light around these, and through its imprint on the Cosmic Microwave Background (CMB). This indirect evidence implies that DM accounts for as much as 84.5% of all matter in our Universe, yet it has so far evaded all attempts at direct detection, leaving such confirmation and the consequent discovery of its nature as one of the biggest challenges in modern physics. Here we present a novel form of low-mass DM χ that would have been missed by all experiments so far. While its large interaction strength might at first seem unlikely, neither constraints from particle physics nor cosmological/astronomical observations are sufficient to rule out this type of DM, and it motivates our proposal for direct detection by optomechanics technology which should soon be within reach, namely, through the precise position measurement of a levitated mesoscopic particle which will be perturbed by elastic collisions with χ particles. We show that a recently proposed nanoparticle matter-wave interferometer, originally conceived for tests of the quantum superposition principle, is sensitive to these collisions, too. PMID:25622565

  5. Bounds on Dark Matter annihilations from 21 cm data arXiv

    CERN Document Server

    D'Amico, Guido; Strumia, Alessandro

    The observation of an absorption feature in the 21 cm spectrum at redshift $z\\approx 17$ implies bounds on Dark Matter annihilations for a broad range of masses, given that significant heating of the intergalactic medium would have erased such feature. The resulting bounds on the DM annihilation cross sections are comparable to the strongest ones from all other observables.

  6. Accumulation and distribution of dry matter in relation to root yield of ...

    African Journals Online (AJOL)

    STORAGESEVER

    2009-10-05

    Oct 5, 2009 ... Cassava an important staple food is grown both in upland and inland valley in the tropics. A trial to ... high dry matter also produce high leaf area index and root yield ..... Proportion (%) of DM accumulated in root stock.

  7. Sensitivity for detection of decay of dark matter particle using ICAL at ...

    Indian Academy of Sciences (India)

    India-based neutrino observatory; iron calorimeter; kolar event; dark matter particle; lifetime. PACS No. ... certain DM energy density in a limited volume of the ICAL cavern. The ICAL ..... of light. This time difference will generally be a positive quantity. ... (a) The lower limit in the lifetime of DMP vs. its mass for μ+μ− decay.

  8. Comparison between in situ dry matter degradation and in vitro gas ...

    African Journals Online (AJOL)

    Dry matter (DM) degradation of Glycrrhiza glabra L, Arbutus andrachne, Juniperus communis, and Pistica lentiscus was determined using two different techniques: (i) the in vitro gas production and (ii) the in situ nylon bag degradability technique. Samples were incubated in situ and in vitro for 3, 6, 12, 24, 48, 72 and 96 h.

  9. On the Existence of Low-Mass Dark Matter and its Direct Detection

    Science.gov (United States)

    Bateman, James; McHardy, Ian; Merle, Alexander; Morris, Tim R.; Ulbricht, Hendrik

    2015-01-01

    Dark Matter (DM) is an elusive form of matter which has been postulated to explain astronomical observations through its gravitational effects on stars and galaxies, gravitational lensing of light around these, and through its imprint on the Cosmic Microwave Background (CMB). This indirect evidence implies that DM accounts for as much as 84.5% of all matter in our Universe, yet it has so far evaded all attempts at direct detection, leaving such confirmation and the consequent discovery of its nature as one of the biggest challenges in modern physics. Here we present a novel form of low-mass DM χ that would have been missed by all experiments so far. While its large interaction strength might at first seem unlikely, neither constraints from particle physics nor cosmological/astronomical observations are sufficient to rule out this type of DM, and it motivates our proposal for direct detection by optomechanics technology which should soon be within reach, namely, through the precise position measurement of a levitated mesoscopic particle which will be perturbed by elastic collisions with χ particles. We show that a recently proposed nanoparticle matter-wave interferometer, originally conceived for tests of the quantum superposition principle, is sensitive to these collisions, too.

  10. Comparison of in situ dry matter degradation parameters with in vitro ...

    African Journals Online (AJOL)

    Adem Kamalak

    The rate and extent of fermentation of dry matter (DM) in the rumen are very important determinants ... kinetics of forages obtained by the in situ nylon bag technique and the in vitro gas production technique. (Blummel & Ørskov ..... not find any correlation between these parameters in barley and wheat straw. Beuvinik et al.

  11. Solar Extreme UV radiation and quark nugget dark matter model

    Energy Technology Data Exchange (ETDEWEB)

    Zhitnitsky, Ariel, E-mail: arz@phas.ubc.ca [Department of Physics and Astronomy, University of British Columbia, Vancouver, B.C. V6T 1Z1 (Canada)

    2017-10-01

    We advocate the idea that the surprising emission of extreme ultra violet (EUV) radiation and soft x-rays from the Sun are powered externally by incident dark matter (DM) particles. The energy and the spectral shape of this otherwise unexpected solar irradiation is estimated within the quark nugget dark matter model. This model was originally invented as a natural explanation of the observed ratio Ω{sub dark} ∼ Ω{sub visible} when the DM and visible matter densities assume the same order of magnitude values. This generic consequence of the model is a result of the common origin of both types of matter which are formed during the same QCD transition and both proportional to the same fundamental dimensional parameter Λ{sub QCD}. We also present arguments suggesting that the transient brightening-like 'nanoflares' in the Sun may be related to the annihilation events which inevitably occur in the solar atmosphere within this dark matter scenario.

  12. Correlation between dark matter and dark radiation in string compactifications

    International Nuclear Information System (INIS)

    Allahverdi, Rouzbeh; Cicoli, Michele; Dutta, Bhaskar; Sinha, Kuver

    2014-01-01

    Reheating in string compactifications is generically driven by the decay of the lightest modulus which produces Standard Model particles, dark matter and light hidden sector degrees of freedom that behave as dark radiation. This common origin allows us to find an interesting correlation between dark matter and dark radiation. By combining present upper bounds on the effective number of neutrino species N eff with lower bounds on the reheating temperature as a function of the dark matter mass m DM from Fermi data, we obtain strong constraints on the (N eff , m DM )-plane. Most of the allowed region in this plane corresponds to non-thermal scenarios with Higgsino-like dark matter. Thermal dark matter can be allowed only if N eff tends to its Standard Model value. We show that the above situation is realised in models with perturbative moduli stabilisation where the production of dark radiation is unavoidable since bulk closed string axions remain light and do not get eaten up by anomalous U(1)s

  13. Galaxy Formation in Sterile Neutrino Dark Matter Models

    Science.gov (United States)

    Menci, N.; Grazian, A.; Lamastra, A.; Calura, F.; Castellano, M.; Santini, P.

    2018-02-01

    We investigate galaxy formation in models with dark matter (DM) constituted by sterile neutrinos. Given their large parameter space, defined by the combinations of sterile neutrino mass {m}ν and mixing parameter {\\sin }2(2θ ) with active neutrinos, we focus on models with {m}ν =7 {keV}, consistent with the tentative 3.5 keV line detected in several X-ray spectra of clusters and galaxies. We consider (1) two resonant production models with {\\sin }2(2θ )=5 × {10}-11 and {\\sin }2(2θ )=2 × {10}-10, to cover the range of mixing parameters consistent with the 3.5 keV line; (2) two scalar-decay models, representative of the two possible cases characterizing such a scenario: a freeze-in and a freeze-out case. We also consider thermal warm DM with particle mass {m}X=3 {keV}. Using a semianalytic model, we compare the predictions for the different DM scenarios with a wide set of observables. We find that comparing the predicted evolution of the stellar mass function, the abundance of satellites of Milky Way–like galaxies, and the global star formation history of galaxies with observations does not allow us to disentangle the effects of the baryonic physics from those related to the different DM models. On the other hand, the distribution of the stellar-to-halo mass ratios, the abundance of faint galaxies in the UV luminosity function at z≳ 6, and the specific star formation and age distribution of local, low-mass galaxies constitute potential probes for the DM scenarios considered. We discuss how future observations with upcoming facilities will enable us to rule out or to strongly support DM models based on sterile neutrinos.

  14. Effect of defoliation frequency and height of cutting on growth, dry matter yield and nutritive value of Napier grass (Pennisetum purpureum (L.) Schumach)

    NARCIS (Netherlands)

    Tessema, Z.K.; Mihret, J.; Solomon, M.

    2010-01-01

    Growth characteristics, dry-matter (DM) yield, chemical components and in vitro dry-matter digestibility (IVDMD) of Napier grass were studied in a randomized complete block design with three replications at Haramaya University, Ethiopia. The treatments were three defoliation frequencies (60, 90 and

  15. Baryon-to-dark matter ratio from random angular fields

    International Nuclear Information System (INIS)

    McDonald, John

    2013-01-01

    We consider the baryon-to-dark matter ratio in models where the dark matter and baryon densities depend on angular fields θ d and θ b according to ρ d ∝θ d α and ρ b ∝θ b β , with all values of θ d and θ b being equally probable in a given randomly-selected domain. Under the assumption that anthropic selection depends primarily on the baryon density in galaxies at spherical collapse, we show that the probability density function for the baryon-to-dark matter ratio r = Ω B /Ω DM is purely statistical in nature and is independent of anthropic selection. We compute the probability density function for r as a function of α and β and show that the observed value of the baryon-to-dark matter ratio, r ≈ 1/5, is natural in this framework

  16. Cortical and Subcortical Grey and White Matter Atrophy in Myotonic Dystrophies Type 1 and 2 Is Associated with Cognitive Impairment, Depression and Daytime Sleepiness.

    Directory of Open Access Journals (Sweden)

    Christiane Schneider-Gold

    Full Text Available Central nervous system involvement is one important clinical aspect of myotonic dystrophy type 1 and 2 (DM1 and DM2. We assessed CNS involvement DM1 and DM2 by 3T MRI and correlated clinical and neuocognitive symptoms with brain volumetry and voxel-based morphometry (VBM.12 patients with juvenile or classical DM1 and 16 adult DM2 patients underwent 3T MRI, a thorough neurological and neuropsychological examination and scoring of depression and daytime sleepiness. Volumes of brain, ventricles, cerebellum, brainstem, cervical cord, lesion load and VBM results of the patient groups were compared to 33 matched healthy subjects.Clinical symptoms were depression (more pronounced in DM2, excessive daytime sleepiness (more pronounced in DM1, reduced attention and flexibility of thinking, and deficits of short-term memory and visuo-spatial abilities in both patient groups. Both groups showed ventricular enlargement and supratentorial GM and WM atrophy, with prevalence for more GM atrophy and involvement of the motor system in DM1 and more WM reduction and affection of limbic structures in DM2. White matter was reduced in DM1 in the splenium of the corpus callosum and in left-hemispheric WM adjacent to the pre- and post-central gyrus. In DM2, the bilateral cingulate gyrus and subgyral medio-frontal and primary somato-sensory WM was affected. Significant structural-functional correlations of morphological MRI findings (global volumetry and VBM with clinical findings were found for reduced flexibility of thinking and atrophy of the left secondary visual cortex in DM1 and of distinct subcortical brain structures in DM2. In DM2, depression was associated with brainstem atrophy, Daytime sleepiness correlated with volume decrease in the middle cerebellar peduncles, pons/midbrain and the right medio-frontal cortex.GM and WM atrophy was significant in DM1 and DM2. Specific functional-structural associations related morphological changes to cognitive impairment

  17. Dark Matter Equation of State through Cosmic History

    Science.gov (United States)

    Kopp, Michael; Skordis, Constantinos; Thomas, Daniel B.; Ilić, Stéphane

    2018-06-01

    Cold dark matter is a crucial constituent of the current concordance cosmological model. Having a vanishing equation of state (EOS), its energy density scales with the inverse cosmic volume and is thus uniquely described by a single number, its present abundance. We test the inverse cosmic volume law for dark matter (DM) by allowing its EOS to vary independently in eight redshift bins in the range z =105 and z =0 . We use the latest measurements of the cosmic microwave background radiation from the Planck satellite and supplement them with baryon acoustic oscillation (BAO) data from the 6dF and SDSS-III BOSS surveys and with the Hubble Space Telescope (HST) key project data. We find no evidence for nonzero EOS in any of the eight redshift bins. With Planck data alone, the DM abundance is most strongly constrained around matter-radiation equality ωgeq=0.119 3-0.0035+0.0036 (95% C.L.), whereas its present-day value is more weakly constrained: ωg(0 )=0.1 6-0.10+0.12 (95% C.L.). Adding BAO or HST data does not significantly change the ωgeq constraint, while ωg(0 ) tightens to 0.16 0-0.065+0.069 (95% C.L.) and 0.12 4-0.067+0.081 (95% C.L.), respectively. Our results constrain for the first time the level of "coldness" required of the DM across various cosmological epochs and show that the DM abundance is strictly positive at all times.

  18. Practical Matters

    DEFF Research Database (Denmark)

    Elle, Birgitte

    Denmark has recently on a small scale tried new initiatives and ways of thinking teacher education out, which implied the students simultaneous trainee employment at a school, and their maintaining of the study activities at the teacher university college. This Danish initiative differs from other...... in western countries well known ways of organising teacher education as school-based, with a strong workplace focus, as well as from the use of the teacher assistant as support staff in schools. This paper discusses key findings and some theoretical implications from the simultaneous follow-up research......-up research made use of notions of decentredness in the ‘situated learning theory’ (Lave & Wenger) and of ‘communities of practice’ (Wenger), and this theoretical basis was further expanded with the notions of power relations and de-naturalised perspectives, (Foucault), and neo-liberalism (Rose). The follow...

  19. Pioglitazone improves the ability of learning and memory via activating ERK1/2 signaling pathway in the hippocampus of T2DM rats.

    Science.gov (United States)

    Gao, F; Zang, L; Wu, D Y; Li, Y J; Zhang, Q; Wang, H B; Tian, G L; Mu, Y M

    2017-06-09

    To explore the correlation between effect of PIO (pioglitazone, PIO) on learning as well as memory and ERK1/2 (extracellular signal regulated kinase 1/2, ERK1/2) pathway in T2DM (type 2 diabetes mellitus, T2DM) rats, further to elucidate the potential mechanism of PIO in improvement of learning and memory. 12-week-old male SD rats (number of 10 per group) were randomly divided into control group (CON), T2DM group (DM) and T2DM +PIO group (DM+PG). Rats in DM and DM+PG groups were given high fat diet for 20 weeks, then treated with Streptozotocin (27mg/kg) by intraperitoneal injection at 21week. After 72h, the FBG (fasting blood glucose, FBG) was greater than 7.0mmol/L can considered T2DM rats. DM+PG group was treated with PIO (10 mg·kg -1 ·d -1 ) by gavage daily. After Hyperinsulinemic-Euglycemic Clamp Study and Morris water maze test at 30-week, all of animals were sacrificed. The expressions of RKIP (Raf-1 kinase inhibitor protein, RKIP) and ERK1/2 in hippocampus were detected using Western Blot and real-time PCR. The FBG level: DM group (7.68±0.54mmol/L) was higher than CON group (5.35±0.63mmol/L) and DM+PG group (6.07±0.84mmol/L), the differences were considered statistically significant (P 0.05); The relative content of p-ERK1/2 protein in CON group and DM+PG group rats dorsal were higher than those in group DM, the difference was considered statistically significant (P0.05). Activation of ERK1/2 signal transduction pathway via reducing RKIP in the hippocampus may be one of the mechanisms of PIO to improve the learning and memory of the T2DM rats. Copyright © 2017 Elsevier B.V. All rights reserved.

  20. Living with a Red Dwarf: A Chandra Archival Study of dM Star Activity and Habitability

    Science.gov (United States)

    Engle, Scott

    2017-09-01

    We propose to analyze 6 archival Chandra visits, not pointed at, but serendipitously including 3 dM stars of known age. GJ 669 AB are a common proper motion pair, each are resolved and detected in 3 exposures, and LHS 373 is a much older dM star also detected on 3 exposures. Photometry (by us) of GJ 669 AB began 5 years ago, is ongoing, and has precisely determined rotation rates for both stars and evidence of frequent flaring from GJ 669 B. We will analyze the multiple exposures, derive an accurate mean level of X-ray activity from the targets, and also separate out and individually analyze and model any observed X-ray flares. This proposal will provide highly accurate coronal properties for the targets, but also very useful data for stellar evolution and planetary habitability studies.

  1. REFORMASI SISTEM AKUNTANSI CASH BASIS MENUJU SISTEM AKUNTANSI ACCRUAL BASIS

    Directory of Open Access Journals (Sweden)

    Yuri Rahayu

    2016-03-01

    Full Text Available Abstract –  Accounting reform movement was born with the aim of structuring the direction of improvement . This movement is characterized by the enactment of the Act of 2003 and Act 1 of 2004, which became the basis of the birth of Government Regulation No.24 of 2005 on Government Accounting Standards ( SAP . The general,  accounting is based on two systems,  the cash basis  and the accrual basis. The facts speak far students still at problem with differences to the two methods that result in a lack of understanding on the treatment system for recording. The purpose method of research is particularly relevant to student references who are learning basic accounting so that it can provide information and more meaningful understanding of the accounting method cash basis and Accrual basis. This research was conducted through a normative approach, by tracing the document that references a study/library that combines source of reference that can be believed either from books and the internet are processed with a foundation of knowledge and experience of the author. The conclusion can be drawn that basically to be able to understand the difference of the system and the Cash Basis accrual student base treatment requires an understanding of both methods. To be able to have the ability and understanding of both systems required reading exercises and reference sources.   Keywords : Reform, cash basis, accrual basis   Abstrak - Gerakan reformasi akuntansi dilahirkan dengan tujuan penataan ke arah perbaikan. Gerakan ini  ditandai dengan dikeluarkannya  Undang-Undang tahun 2003 dan Undang-Undang No.1 Tahun 2004  yang menjadi dasar lahirnya Peraturan Pemerintah No.24 Tahun 2005 tentang Standar Akuntansi Pemerintah (SAP . Pada umumnya pencatatan akuntansi di dasarkan pada dua sistem yaitu basis kas (Cash Basis dan basis akrual  (Accrual Basis. Fakta berbicara Selama ini mahasiswa masih dibinggungkan dengan perbedaan ke dua metode itu sehingga

  2. Directly Detecting MeV-Scale Dark Matter Via Solar Reflection.

    Science.gov (United States)

    An, Haipeng; Pospelov, Maxim; Pradler, Josef; Ritz, Adam

    2018-04-06

    If dark matter (DM) particles are lighter than a few   MeV/c^{2} and can scatter off electrons, their interaction within the solar interior results in a considerable hardening of the spectrum of galactic dark matter received on Earth. For a large range of the mass versus cross section parameter space, {m_{e},σ_{e}}, the "reflected" component of the DM flux is far more energetic than the end point of the ambient galactic DM energy distribution, making it detectable with existing DM detectors sensitive to an energy deposition of 10-10^{3}  eV. After numerically simulating the small reflected component of the DM flux, we calculate its subsequent signal due to scattering on detector electrons, deriving new constraints on σ_{e} in the MeV and sub-MeV range using existing data from the XENON10/100, LUX, PandaX-II, and XENON1T experiments, as well as making projections for future low threshold direct detection experiments.

  3. Directly Detecting MeV-Scale Dark Matter Via Solar Reflection

    Science.gov (United States)

    An, Haipeng; Pospelov, Maxim; Pradler, Josef; Ritz, Adam

    2018-04-01

    If dark matter (DM) particles are lighter than a few MeV /c2 and can scatter off electrons, their interaction within the solar interior results in a considerable hardening of the spectrum of galactic dark matter received on Earth. For a large range of the mass versus cross section parameter space, {me,σe}, the "reflected" component of the DM flux is far more energetic than the end point of the ambient galactic DM energy distribution, making it detectable with existing DM detectors sensitive to an energy deposition of 10 -103 eV . After numerically simulating the small reflected component of the DM flux, we calculate its subsequent signal due to scattering on detector electrons, deriving new constraints on σe in the MeV and sub-MeV range using existing data from the XENON10/100, LUX, PandaX-II, and XENON1T experiments, as well as making projections for future low threshold direct detection experiments.

  4. On dark matter interactions with the Standard Model through an anomalous Z'

    Science.gov (United States)

    Ismail, Ahmed; Katz, Andrey; Racco, Davide

    2017-10-01

    We study electroweak scale Dark Matter (DM) whose interactions with baryonic matter are mediated by a heavy anomalous Z'. We emphasize that when the DM is a Majorana particle, its low-velocity annihilations are dominated by loop suppressed annihilations into the gauge bosons, rather than by p-wave or chirally suppressed annihilations into the SM fermions. Because the Z ' is anomalous, these kinds of DM models can be realized only as effective field theories (EFTs) with a well-defined cutoff, where heavy spectator fermions restore gauge invariance at high energies. We formulate these EFTs, estimate their cutoff and properly take into account the effect of the Chern-Simons terms one obtains after the spectator fermions are integrated out. We find that, while for light DM collider and direct detection experiments usually provide the strongest bounds, the bounds at higher masses are heavily dominated by indirect detection experiments, due to strong annihilation into W + W -, ZZ, Zγ and possibly into gg and γγ. We emphasize that these annihilation channels are generically significant because of the structure of the EFT, and therefore these models are prone to strong indirect detection constraints. Even though we focus on selected Z' models for illustrative purposes, our setup is completely generic and can be used for analyzing the predictions of any anomalous Z'-mediated DM model with arbitrary charges.

  5. Acceptable risk as a basis for design

    International Nuclear Information System (INIS)

    Vrijling, J.K.; Hengel, W. van; Houben, R.J.

    1998-01-01

    Historically, human civilisations have striven to protect themselves against natural and man-made hazards. The degree of protection is a matter of political choice. Today this choice should be expressed in terms of risk and acceptable probability of failure to form the basis of the probabilistic design of the protection. It is additionally argued that the choice for a certain technology and the connected risk is made in a cost-benefit framework. The benefits and the costs including risk are weighed in the decision process. A set of rules for the evaluation of risk is proposed and tested in cases. The set of rules leads to technical advice in a question that has to be decided politically

  6. DM2 results on e+e- annihilation into multihadrons in the 1350-2400 MeV energy range

    International Nuclear Information System (INIS)

    Bisello, D.; Busetto, G.; Castro, A.; Nigro, M.; Pescara, L.; Sartori, P.; Stanco, L.; Antonelli, A.; Baldini, R.; Biagini, M.E.; Calcaterra, A.; Schioppa, M.; Augustin, J.E.; Cosme, G.; Couchot, F.; Fulda, F.; Grosdidier, G.; Jean-Marie, B.; Lepeltier, V.; Szklarz, G.

    1990-06-01

    We present preliminary results on the study of e + e - annihilation into π + π - π + π - , π + π - π 0 π 0 , π + π - π 0 , π + π - π + π - π 0 , K + K - π + π - and K s 0 K ± π -+ in the 1350-2400 MeV energy range. Data have been collected with the DM2 detector at DCI, the Orsay colliding ring, and refer to about 2 pb -1 integrated luminosity

  7. Baryonic matter and beyond

    OpenAIRE

    Fukushima, Kenji

    2014-01-01

    We summarize recent developments in identifying the ground state of dense baryonic matter and beyond. The topics include deconfinement from baryonic matter to quark matter, a diquark mixture, topological effect coupled with chirality and density, and inhomogeneous chiral condensates.

  8. Weak annihilation cusp inside the dark matter spike about a black hole.

    Science.gov (United States)

    Shapiro, Stuart L; Shelton, Jessie

    2016-06-15

    We reinvestigate the effect of annihilations on the distribution of collisionless dark matter (DM) in a spherical density spike around a massive black hole. We first construct a very simple, pedagogic, analytic model for an isotropic phase space distribution function that accounts for annihilation and reproduces the "weak cusp" found by Vasiliev for DM deep within the spike and away from its boundaries. The DM density in the cusp varies as r -1/2 for s -wave annihilation, where r is the distance from the central black hole, and is not a flat "plateau" profile. We then extend this model by incorporating a loss cone that accounts for the capture of DM particles by the hole. The loss cone is implemented by a boundary condition that removes capture orbits, resulting in an anisotropic distribution function. Finally, we evolve an initial spike distribution function by integrating the Boltzmann equation to show how the weak cusp grows and its density decreases with time. We treat two cases, one for s -wave and the other for p -wave DM annihilation, adopting parameters characteristic of the Milky Way nuclear core and typical WIMP models for DM. The cusp density profile for p -wave annihilation is weaker, varying like ~ r -0.34 , but is still not a flat plateau.

  9. Explaining the DAMPE data with scalar dark matter and gauged U(1)Le-Lμ interaction

    International Nuclear Information System (INIS)

    Cao, Junjie; Feng, Lei; Guo, Xiaofei; Shang, Liangliang; Wang, Fei; Wu, Peiwen; Zu, Lei

    2018-01-01

    Inspired by the peak structure observed by recent DAMPE experiment in e + e - cosmic-ray spectrum, we consider a scalar dark matter (DM) model with gauged U(1) L e -L μ symmetry, which is the most economical anomaly-free theory to potentially explain the peak by DM annihilation in nearby subhalo. We utilize the process χχ → Z ' Z ' → l anti ll ' anti l ' , where χ, Z ' , l (') denote the scalar DM, the new gauge boson and l (') = e, μ, respectively, to generate the e + e - spectrum. By fitting the predicted spectrum to the experimental data, we obtain the favored DM mass range m χ ≅ 3060 +80 -100 GeV and Δm ≡ m χ - m Z' DM relic abundance, DM direct detection and the collider bounds. We conclude that the model we consider can account for the peak, although there exists a tension with the constraints from the LEP-II bound on m Z' arising from the cross section measurement of e + e - → Z '* → e + e - . (orig.)

  10. Astrophysics-independent bounds on the annual modulation of dark matter signals.

    Science.gov (United States)

    Herrero-Garcia, Juan; Schwetz, Thomas; Zupan, Jure

    2012-10-05

    We show how constraints on the time integrated event rate from a given dark matter (DM) direct detection experiment can be used to bound the amplitude of the annual modulation signal in another experiment. The method requires only mild assumptions about the properties of the local DM distribution: that it is temporally stable on the scale of months and spatially homogeneous on the ecliptic. We apply the method to the annual modulation signal in DAMA/LIBRA, which we compare to the bounds derived from XENON10, XENON100, cryogenic DM search, and SIMPLE data. Assuming a DM mass of 10 GeV, we show that under the above assumptions about the DM halo, a DM interpretation of the DAMA/LIBRA signal is excluded for several classes of models: at 6.3σ (4.6σ) for elastic isospin conserving (violating) spin-independent interactions, and at 4.9σ for elastic spin-dependent interactions on protons.

  11. MENGUKUR KESUKSESAN SISTEM AKUNTANSI INSTANSI BASIS AKRUAL (SAIBA MENGGUNAKAN MODEL DeLONE & McLEAN

    Directory of Open Access Journals (Sweden)

    Noviyanti Noviyanti

    2017-01-01

    Full Text Available ABSTRACT The aim of this study is to determine the user’s perception of Accrual Basis Institution Accounting System  (SAIBA in the ministry/agency in the first year of implementation of accrual-based government’s financial statements. Updated D & M IS Success Model is used to assess the success of SAIBA as a mandatory system in Indonesian Government Accounting. Respondents are operators of Institution Accounting System (SAI in the ministries/agencies, who are joining the Workshop on Preparation and Study of Financial Statements at Pusdiklat Anggaran dan Perbendaharaan  Bogor in November 2015  and selected using purposive sampling method. The Primary data were obtained through questionnaires that were collected from 204 respondents, which were then analyzed using structural equation modeling. This study found that SAIBA can be categorized as a successful information for each dimension of success in the Updated D&M IS Success Model. Respondents assessed the system quality, the information quality and service quality of SAIBA tend to be good. However, respondents indicated the use of SAIBA has no significant effect on user satisfaction, in contrast to the others constructs relationships, the system quality, the information quality and service quality of SAIBA with net benefit and its reciprocal proved to be significant impact. Keywords:  SAIBA, updated D&M IS Success Model, accrual basis, government accounting, institution accounting system ABSTRAK Penelitian ini bertujuan untuk mengetahui persepsi pengguna terhadap Sistem Akuntansi Instansi Basis Akrual (SAIBA pada Kementerian/Lembaga di tahun pertama penggunaanya pada pembuatan laporan keuangan pemerintah basis akrual. Model Kesuksesan Sistem Informasi yang diperbaharui (Updated D&M IS Success Model digunakan untuk menilai kesuksesan SAIBA yang penggunaannya bersifat wajib pada Akuntansi Pemerintahan Indonesia yang berbasis akrual. Responden adalah operator Sistem Akuntansi Instansi (SAI

  12. Relationship between serum leptin levels, ATPase activity of erythrocyte membrance and development of diabetic nephropathy in patients with DM2

    International Nuclear Information System (INIS)

    Wang Yuming

    2009-01-01

    Objective: To study the possible mechanism of development of nephrosis affected by changes of serum leptin levels and alteration of activities of Na + K + -ATPase and Ca 2+ Mg 2+ -ATPase of erythrocyte membrane in patients with type 2 diabetes(DM2). Methods: Serum leptin levels (with RIA) and erythrocyte membrane Na + K + -ATPase and Ca 2+ Mg 2+ -ATPase activitities (with Reinila method) were determined in 40 DM2 patients without nephropathy, 32 DM2 patients with nephropathy and 35 controls. Results Serum leptin levels were significantly higher in the diabetics as a whole than those in controls (P + K + -ATPase and Ca 2+ Mg 2+ -ATPase activities were significantly lower (P<0.01). Among the diabetic patients, the serum leptin levels in patients without nephrosis (P<0.05), but the RBC membrance ATPase activities were significantly lower(P<0.05). Conclusion: Development of type 2 diabetes nephrosis might be correlated with the high serum leptin level and decreased ATPase activities of erythrocite membrane. (authors)

  13. The Drosophila melanogaster DmCK2beta transcription unit encodes for functionally non-redundant protein isoforms.

    Science.gov (United States)

    Jauch, Eike; Wecklein, Heike; Stark, Felix; Jauch, Mandy; Raabe, Thomas

    2006-06-07

    Genes encoding for the two evolutionary highly conserved subunits of a heterotetrameric protein kinase CK2 holoenzyme are present in all examined eukaryotic genomes. Depending on the organism, multiple transcription units encoding for a catalytically active CK2alpha subunit and/or a regulatory CK2beta subunit may exist. The phosphotransferase activity of members of the protein kinase CK2alpha family is thought to be independent of second messengers but is modulated by interaction with CK2beta-like proteins. In the genome of Drosophila melanogaster, one gene encoding for a CK2alpha subunit and three genes encoding for CK2beta-like proteins are present. The X-linked DmCK2beta transcription unit encodes for several CK2beta protein isoforms due to alternative splicing of its primary transcript. We addressed the question whether CK2beta-like proteins are redundant in function. Our in vivo experiments show that variations of the very C-terminal tail of CK2beta isoforms encoded by the X-linked DmCK2beta transcription unit influence their functional properties. In addition, we find that CK2beta-like proteins encoded by the autosomal D. melanogaster genes CK2betates and CK2beta' cannot fully substitute for a loss of CK2beta isoforms encoded by DmCK2beta.

  14. Mitigation of Membrane Biofouling in MBR Using a Cellulolytic Bacterium, Undibacterium sp. DM-1, Isolated from Activated Sludge.

    Science.gov (United States)

    Nahm, Chang Hyun; Lee, Seonki; Lee, Sang Hyun; Lee, Kibaek; Lee, Jaewoo; Kwon, Hyeokpil; Choo, Kwang-Ho; Lee, Jung-Kee; Jang, Jae Young; Lee, Chung-Hak; Park, Pyung-Kyu

    2017-03-28

    Biofilm formation on the membrane surface results in the loss of permeability in membrane bioreactors (MBRs) for wastewater treatment. Studies have revealed that cellulose is not only produced by a number of bacterial species but also plays a key role during formation of their biofilm. Hence, in this study, cellulase was introduced to a MBR as a cellulose-induced biofilm control strategy. For practical application of cellulase to MBR, a cellulolytic ( i.e ., cellulase-producing) bacterium, Undibacterium sp. DM-1, was isolated from a lab-scale MBR for wastewater treatment. Prior to its application to MBR, it was confirmed that the cell-free supernatant of DM-1 was capable of inhibiting biofilm formation and of detaching the mature biofilm of activated sludge and cellulose-producing bacteria. This suggested that cellulase could be an effective anti-biofouling agent for MBRs used in wastewater treatment. Undibacterium sp. DM-1-entrapping beads ( i.e ., cellulolytic-beads) were applied to a continuous MBR to mitigate membrane biofouling 2.2-fold, compared with an MBR with vacant-beads as a control. Subsequent analysis of the cellulose content in the biofilm formed on the membrane surface revealed that this mitigation was associated with an approximately 30% reduction in cellulose by cellulolytic-beads in MBR.

  15. Under the sword of Damocles: plausible regeneration of dark matter cusps at the smallest galactic scales

    Science.gov (United States)

    Laporte, Chervin F. P.; Peñarrubia, Jorge

    2015-04-01

    We study the evolution of the dark matter (DM) halo profiles of dwarf galaxies driven by the accretion of DM substructures through controlled N-body experiments. Our initial conditions assume that early supernova feedback erases the primordial DM cusps of haloes with z = 0 masses of 109 - 1010 M⊙. The orbits and masses of the infalling substructures are borrowed from the Aquarius cosmological simulations. Our experiments show that a fraction of haloes that undergo 1:3 down to 1:30 mergers are susceptible to reform a DM cusp by z ≈ 0. Cusp regrowth is driven by the accretion of DM substructures that are dense enough to reach the central regions of the main halo before being tidally disrupted. The infall of substructures on the mean of the reported mass-concentration relation and a mass ratio above 1:6 systematically leads to cusp regrowth. Substructures with 1:6-1:8, and 1:8-1:30 only reform DM cusps if their densities are 1σ and 2σ above the mean, respectively. The merging time-scales of these dense, low-mass substructures is relatively long (5 - 11 Gyr), which may pose a time-scale problem for the longevity of DM cores in dwarfs galaxies and possibly explain the existence of dense dwarfs-like Draco. These results suggest that within cold dark matter a non-negligible level of scatter in the mass profiles of galactic haloes acted on by feedback is to be expected given the stochastic mass accretion histories of low-mass haloes and the diverse star formation histories observed in the Local Group dwarfs.

  16. Front Matter

    Directory of Open Access Journals (Sweden)

    HLRC Editor

    2016-08-01

    Full Text Available Higher Learning Research Communications (HLRC, ISSN: 2157-6254 [Online] is published collaboratively by Walden University (USA, Universidad Andrés Bello (Chile, Universidad Europea de Madrid (Spain and Istanbul Bilgi University (Turkey. Written communication to HLRC should be addressed to the office of the Executive Director at Laureate Education, Inc. 701 Brickell Ave Ste. 1700, Miami, FL 33131, USA. HLRC is designed for open access and online distribution through www.hlrcjournal.com. The views and statements expressed in this journal do not necessarily reflect the views of Laureate Education, Inc. or any of its affiliates (collectively “Laureate”. Laureate does not warrant the accuracy, reliability, currency or completeness of those views or statements and does not accept any legal liability arising from any reliance on the views, statements and subject matter of the journal. Acknowledgements The Guest Editors gratefully acknowledge the substantial contribution of the readers for the blind peer review of essays submitted for this special issue as exemplars of individuals from around the world who have come together in a collective endeavor for the common good: Robert Bringle (Indiana University Purdue University Indianapolis, US, Linda Buckley (University of the Pacific, US, Guillermo Calleja (Universidad Rey Juan Carlos, Spain, Eva Egron-Polak (International Association of Universities, France, Heather Friesen (Abu Dhabi University, UAE, Saran Gill (National University of Malaysia, Malaysia, Chester Haskell (higher education consultant, US, Kanokkarn Kaewnuch (National Institute for Development Administration, Thailand, Gil Latz (Indiana University Purdue University Indianapolis, US, Molly Lee (higher education consultant, Malaysia, Deane Neubauer (East-West Center at University of Hawaii, US, Susan Sutton (Bryn Mawr College, US, Francis Wambalaba (United States International University, Kenya, and Richard Winn (higher education

  17. Making the most of the relic density for dark matter searches at the LHC 14 TeV Run

    International Nuclear Information System (INIS)

    Busoni, Giorgio; Simone, Andrea De; Jacques, Thomas; Morgante, Enrico; Riotto, Antonio

    2015-01-01

    As the LHC continues to search for new weakly interacting particles, it is important to remember that the search is strongly motivated by the existence of dark matter. In view of a possible positive signal, it is essential to ask whether the newly discovered weakly interacting particle can be be assigned the label 'dark matter'. Within a given set of simplified models and modest working assumptions, we reinterpret the relic abundance bound as a relic abundance range, and compare the parameter space yielding the correct relic abundance with projections of the Run II exclusion regions. Assuming that dark matter is within the reach of the LHC, we also make the comparison with the potential 5σ discovery regions. Reversing the logic, relic density calculations can be used to optimize dark matter searches by motivating choices of parameters where the LHC can probe most deeply into the dark matter parameter space. In the event that DM is seen outside of the region giving the correct relic abundance, we will learn that either thermal relic DM is ruled out in that model, or the DM-quark coupling is suppressed relative to the DM coupling strength to other SM particles

  18. X- rays and matter- the basic interactions

    DEFF Research Database (Denmark)

    Als-Nielsen, Jens

    2008-01-01

    In this introductory article we attempt to provide the theoretical basis for developing the interaction between X-rays and matter, so that one can unravel properties of matter by interpretation of X-ray experiments on samples. We emphasize that we are dealing with the basics, which means that we...... shall limit ourselves to a discussion of the interaction of an X-ray photon with an isolated atom, or rather with a single electron in a Hartree-Fock atom. Subsequent articles in this issue deal with more complicated - and interesting - forms of matter encompassing many atoms or molecules. To cite...

  19. Poor glycemic control impacts linear and non-linear dynamics of heart rate in DM type 2

    Directory of Open Access Journals (Sweden)

    Daniela Bassi

    2015-08-01

    Full Text Available INTRODUCTION: It is well known that type 2 diabetes mellitus (T2DM produces cardiovascular autonomic neuropathy (CAN, which may affect the cardiac autonomic modulation. However, it is unclear whether the lack of glycemic control in T2DM without CAN could impact negatively on cardiac autonomic modulation. Objective: To evaluate the relationship between glycemic control and cardiac autonomic modulation in individuals with T2DM without CAN. Descriptive, prospective and cross sectional study.METHODS: Forty-nine patients with T2DM (51±7 years were divided into two groups according to glycosylated hemoglobin (HbA1c: G1≤7% and G2>7.0%. Resting heart rate (HR and RR interval (RRi were obtained and calculated by linear (Mean iRR; Mean HR; rMSSD; STD RR; LF; HF; LF/HF, TINN and RR Tri, and non-linear (SD1; SD2; DFα1; DFα2, Shannon entropy; ApEn; SampEn and CD methods of heart rate variability (HRV. Insulin, HOMA-IR, fasting glucose and HbA1c were obtained by blood tests.RESULTS: G2 (HbA1c≤7% showed lower values for the mean of iRR; STD RR; RR Tri, TINN, SD2, CD and higher mean HR when compared with G1 (HbA1c > 7%. Additionally, HbA1c correlated negatively with mean RRi (r=0.28, p=0.044; STD RR (r=0.33, p=0.017; RR Tri (r=-0.35, p=0.013, SD2 (r=-0.39, p=0.004 and positively with mean HR (r=0.28, p=0.045. Finally, fasting glucose correlated negatively with STD RR (r=-0.36, p=0.010; RR Tri (r=-0.36, p=0.010; TINN (r=-0.33, p=0.019 and SD2 (r=-0.42, p=0.002.CONCLUSION: We concluded that poor glycemic control is related to cardiac autonomic modulation indices in individuals with T2DM even if they do not present cardiovascular autonomic neuropathy.

  20. Uncontrolled Hypertension and Its Determinants in Patients with Concomitant Type 2 Diabetes Mellitus (T2DM in Rural South Africa.

    Directory of Open Access Journals (Sweden)

    Oladele Vincent Adeniyi

    Full Text Available Paucity of data on the prevalence, treatment and control of hypertension in individuals living with type 2 diabetes mellitus (T2DM in the rural communities of South Africa may undermine efforts to reduce the morbidity and mortality associated with cardiovascular diseases. This study examines the socio-demographic and clinical determinants of uncontrolled hypertension among individuals living with T2DM in the rural communities of Mthatha, South Africa.This cross-sectional study involved a serially selected sample of 265 individuals living with T2DM and hypertension at Mthatha General Hospital, Mthatha. Uncontrolled hypertension was defined as systolic blood pressure greater than or equal to 140 mmHg and diastolic blood pressure greater than or equal to 90mmHg in accordance with the Eight Joint National Committee Report (JNC 8 (2014. We performed univariate and multivariate logistic regression analyses to identify the significant determinants of uncontrolled hypertension.Of the total participants (n = 265, the prevalence of uncontrolled hypertension was 75.5% (n = 200. In univariate analysis of all participants, male gender (p = 0.029, age≥65 years (p = 0.016, unemployed status (p<0.0001, excessive alcohol intake (p = 0.005 and consumption of western-type diet (p<0.0001 were positively associated with uncontrolled hypertension. In multivariate logistic regression (LR method analysis, unemployed status (p<0.0001, excessive alcohol intake (p = 0.007 and consumption of western-type diet (p<0.0001 were independently and significantly associated with uncontrolled hypertension. There is significant association between increasing number and classes of anti-hypertensive drugs and uncontrolled hypertension (p = 0.05 and 0.02, respectively.Prevalence of uncontrolled hypertension was high in individuals with concomitant hypertension and T2DM in the study population. Male sex, aging, clinic inertia, unemployed status and nutritional transitions are the most

  1. The effective field theory of dark matter direct detection

    Energy Technology Data Exchange (ETDEWEB)

    Fitzpatrick, A. Liam; Haxton, Wick; Katz, Emanuel; Lubbers, Nicholas; Xu, Yiming

    2013-02-01

    We extend and explore the general non-relativistic effective theory of dark matter (DM) direct detection. We describe the basic non-relativistic building blocks of operators and discuss their symmetry properties, writing down all Galilean-invariant operators up to quadratic order in momentum transfer arising from exchange of particles of spin 1 or less. Any DM particle theory can be translated into the coefficients of an effective operator and any effective operator can be simply related to most general description of the nuclear response. We find several operators which lead to novel nuclear responses. These responses differ significantly from the standard minimal WIMP cases in their relative coupling strengths to various elements, changing how the results from different experiments should be compared against each other. Response functions are evaluated for common DM targets — F, Na, Ge, I, and Xe — using standard shell model techniques. We point out that each of the nuclear responses is familiar from past studies of semi-leptonic electroweak interactions, and thus potentially testable in weak interaction studies. We provide tables of the full set of required matrix elements at finite momentum transfer for a range of common elements, making a careful and fully model-independent analysis possible. Finally, we discuss embedding non-relativistic effective theory operators into UV models of dark matter.

  2. Common origin of neutrino mass, dark matter and Dirac leptogenesis

    Energy Technology Data Exchange (ETDEWEB)

    Borah, Debasish [Department of Physics, Indian Institute of Technology Guwahati, Assam 781039 (India); Dasgupta, Arnab, E-mail: dborah@iitg.ernet.in, E-mail: arnab.d@iopb.res.in [Institute of Physics, HBNI, Sachivalaya Marg, Bhubaneshwar 751005 (India)

    2016-12-01

    We study the possibility of generating tiny Dirac neutrino masses at one loop level through the scotogenic mechanism such that one of the particles going inside the loop can be a stable cold dark matter (DM) candidate. Majorana mass terms of singlet fermions as well as tree level Dirac neutrino masses are prevented by incorporating the presence of additional discrete symmetries in a minimal fashion, which also guarantee the stability of the dark matter candidate. Due to the absence of total lepton number violation, the observed baryon asymmetry of the Universe is generated through the mechanism of Dirac leptogenesis where an equal and opposite amount of leptonic asymmetry is generated in the left and right handed sectors which are prevented from equilibration due to tiny Dirac Yukawa couplings. Dark matter relic abundance is generated through its usual freeze-out at a temperature much below the scale of leptogenesis. We constrain the relevant parameter space from neutrino mass, baryon asymmetry, Planck bound on dark matter relic abundance, and latest LUX bound on spin independent DM-nucleon scattering cross section. We also discuss the charged lepton flavour violation (μ → e γ) and electric dipole moment of electron in this model in the light of the latest experimental data and constrain the parameter space of the model.

  3. Galactic center gamma-ray excess from dark matter annihilation: is there a black hole spike?

    Science.gov (United States)

    Fields, Brian D; Shapiro, Stuart L; Shelton, Jessie

    2014-10-10

    If the supermassive black hole Sgr A* at the center of the Milky Way grew adiabatically from an initial seed embedded in a Navarro-Frenk-White dark matter (DM) halo, then the DM profile near the hole has steepened into a spike. We calculate the dramatic enhancement to the gamma-ray flux from the Galactic center (GC) from such a spike if the 1-3 GeV excess observed in Fermi data is due to DM annihilations. We find that for the parameter values favored in recent fits, the point-source-like flux from the spike is 35 times greater than the flux from the inner 1° of the halo, far exceeding all Fermi point source detections near the GC. We consider the dependence of the spike signal on astrophysical and particle parameters and conclude that if the GC excess is due to DM, then a canonical adiabatic spike is disfavored by the data. We discuss alternative Galactic histories that predict different spike signals, including (i) the nonadiabatic growth of the black hole, possibly associated with halo and/or black hole mergers, (ii) gravitational interaction of DM with baryons in the dense core, such as heating by stars, or (iii) DM self-interactions. We emphasize that the spike signal is sensitive to a different combination of particle parameters than the halo signal and that the inclusion of a spike component to any DM signal in future analyses would provide novel information about both the history of the GC and the particle physics of DM annihilations.

  4. Real-time dry matter content of corn silage by a microwave sensor

    Directory of Open Access Journals (Sweden)

    Vera Perricone

    2017-05-01

    Full Text Available Daily dry matter (DM intake in dairy cow is a central point to meet nutritional requirements and optimal performance, reducing the incidence of metabolic diseases. DM content of some forages, such as silages, can undergo huge variations during storing, affecting the total daily DM consumed. Reference laboratory method is time consuming and cannot be applied to daily changes in diet composition. Currently, new promising real-time technologies are available to monitor the DM content of feeds. The aim of the study was to test and calibrate a portable microwave sensor (MS for DM content in corn silage samples. Twenty-two samples were collected from a corn silage front; sampling procedure was optimized to collect as much as DM content variability as possible within the samples. MS readings were performed with 3 different methods for each samples: 1 directly on the silage front, 2 with the MS over the collected sample and 3 with MS placed under the sample. After the first MS reading, a correspondent silage sample was obtained by a silage corer for readings 2 and 3 and the laboratory DM content assay. A simple regression analysis was performed (JMP, SAS Institute, Cary, NC, 2015 over obtained data. Results evidences as the best MS reading method is represented by the probe burdening on the sample (R2=0.75 with respect to the other methods. The obtained results outlined as, with a correct reading method, MS can be valuable tool to determine DM content of corn silage directly at farm level.

  5. White matter hyperintensities in middle-aged adults with childhood-onset type 1 diabetes

    Science.gov (United States)

    Nunley, Karen A.; Ryan, Christopher M.; Orchard, Trevor J.; Aizenstein, Howard J.; Jennings, J. Richard; Ryan, John; Zgibor, Janice C.; Boudreau, Robert M.; Costacou, Tina; Maynard, John D.; Miller, Rachel G.

    2015-01-01

    Objective: Although microvascular complications are common in type 1 diabetes mellitus (T1DM), few studies have quantified the severity, risk factors, and implications of cerebral microvascular damage in these patients. As life expectancy in patients with T1DM increases, patients are exposed to age- and disease-related factors that may contribute to cerebral microvascular disease. Methods: Severity and volume of white matter hyperintensities (WMH) and infarcts were quantified in 97 middle-aged patients with childhood-onset T1DM (mean age and duration: 50 and 41 years, respectively) and 81 non-T1DM adults (mean age: 48 years), concurrent with cognitive and health-related measures. Results: Compared with non-T1DM participants, patients had more severe WMH (Fazekas scores 2 and 3 compared with Fazekas score 1, p the group differences in processing speed (13% for digit symbol, 11% for pegboard, both p ≤ 0.05). Among patients, prevalent neuropathies and smoking tripled the odds of high WMH burden, independent of age or disease duration. Associations between measures of blood pressure or hyperglycemia and WMH were not significant. Conclusions: Clinically relevant WMH are evident earlier among middle-aged patients with childhood-onset T1DM and are related to the slower information processing frequently observed in T1DM. Brain imaging in patients with T1DM who have cognitive difficulties, especially those with neuropathies, may help uncover cerebral microvascular damage. Longitudinal studies are warranted to fully characterize WMH development, risk factors, and long-term effects on cognition. PMID:25904692

  6. The development and application of the AstroFit program for complementary dark matter studies

    International Nuclear Information System (INIS)

    Nguyen, Ngoc-Lan Nelly

    2013-02-01

    This doctoral thesis describes the development and application of the AstroFit program. Many studies have shown the existence of dark matter (DM), a mass component that constitutes over eighty percent of the entire matter in the Universe. From historical astrophysical evidence to latest reconstructions with sophisticated methods, the gravitational effect of DM can be shown, but its nature remains unknown. Many theoretical explanations aim at describing DM, for example as weakly interacting massive particles (WIMPs), within particular frameworks. The majority of these frameworks extend the existing standard model of particle physics (SM), so that new particles are added to the known set of elementary particles. One of these frameworks is the constrained supersymmetric standard model (CMSSM) that naturally introduces a DM candidate in form of the lightest supersymmetric particle(LSP). Searches for DM particles are undertaken in three different ways. First, directly with fixed-target experiments that measure WIMPs coming towards the Earth with nuclei of the target material. Second, indirectly by reconstructing DM signatures in particle spectra of known particles observed with ground-based telescopes, spaceborne satellites or balloon-borne experiments. And third, indirectly via direct production of DM at particle colliders such as the Large Hadron Collider (LHC) and energy reconstructions where missing transverse energy is presumably carried away by the DM particles. Global fit programs used in particle physics, such as Fittino, are designed to fit parameters of theories beyond the SM simultaneously that are in accordance with the experimental and observed data in order to probe models and constrain the parameter space. To explore complementarity in DM research, the AstroFit interface program has been developed to combine all available information from direct and indirect searches for DM as well as collider searches for new physics in such global fits. To demonstrate

  7. The development and application of the AstroFit program for complementary dark matter studies

    Energy Technology Data Exchange (ETDEWEB)

    Nguyen, Ngoc-Lan Nelly

    2013-02-15

    This doctoral thesis describes the development and application of the AstroFit program. Many studies have shown the existence of dark matter (DM), a mass component that constitutes over eighty percent of the entire matter in the Universe. From historical astrophysical evidence to latest reconstructions with sophisticated methods, the gravitational effect of DM can be shown, but its nature remains unknown. Many theoretical explanations aim at describing DM, for example as weakly interacting massive particles (WIMPs), within particular frameworks. The majority of these frameworks extend the existing standard model of particle physics (SM), so that new particles are added to the known set of elementary particles. One of these frameworks is the constrained supersymmetric standard model (CMSSM) that naturally introduces a DM candidate in form of the lightest supersymmetric particle(LSP). Searches for DM particles are undertaken in three different ways. First, directly with fixed-target experiments that measure WIMPs coming towards the Earth with nuclei of the target material. Second, indirectly by reconstructing DM signatures in particle spectra of known particles observed with ground-based telescopes, spaceborne satellites or balloon-borne experiments. And third, indirectly via direct production of DM at particle colliders such as the Large Hadron Collider (LHC) and energy reconstructions where missing transverse energy is presumably carried away by the DM particles. Global fit programs used in particle physics, such as Fittino, are designed to fit parameters of theories beyond the SM simultaneously that are in accordance with the experimental and observed data in order to probe models and constrain the parameter space. To explore complementarity in DM research, the AstroFit interface program has been developed to combine all available information from direct and indirect searches for DM as well as collider searches for new physics in such global fits. To demonstrate

  8. Phenomenology of Dark Matter from radio to gamma ray frequencies

    International Nuclear Information System (INIS)

    Vollmann, Martin

    2015-07-01

    Multiwavelength astronomical observations have been proven to be of crucial relevance in understanding the most fundamental questions in physics. One of the biggest mysteries of nature is the existence of a (still) unidentified type of matter that makes up most of the material universe. Although little is known about its nature, it is very likely that this exotic Dark Matter (DM) is made of so-called Weakly Interacting Massive Particles (WIMPs). In this thesis we investigate which strategies can best address the fundamental question: What is Dark Matter? Specifically, by following the ''WIMP'' paradigm as our guiding principle, we comprehensively discuss the phenomenology of prospective ''indirect'' detection scenarios of such WIMPs. Special consideration is given to extraterrestrial gamma rays and radio waves produced around the center of the Milky Way. In light of two recently highly debated claims of WIMP Dark Matter discovery, namely the 130 GeV gamma-ray line and the GeV gamma-ray excess, we invoke our methods to confront those hypotheses. In addition our study contains antiparticle cosmic-ray (antiproton and positron) data analyses. The phenomenology for indirect DM detection with these ''messengers'' is briefly discussed as well. By exploiting the high degree of symmetry of typical annihilating 2-WIMP initial states, we are able to employ a very powerful tool in theoretical particle physics: the generalized optical theorem. This theorem relates the amplitude of loop-suppressed processes, such as the 130 GeV line if interpreted as product of WIMP annihilations, with tree-level process which are constrained in the same way as with the GeV excess. Unprecedentedly reported analytical computations of partial-wave (and helicity) cross sections with general applicability are calculated and applied. The possibility that a non-trivial effect in the particle model for DM might enhance the strength of a gamma

  9. On the Possible Links Between Electroweak Symmetry Breaking and Dark Matter

    International Nuclear Information System (INIS)

    Hambye, Thomas; Tytgat, Michel H. G.

    2009-01-01

    The mechanism behind electroweak symmetry breaking (EWSB) and the nature of dark matter (DM) are currently very important issues in particle physics. Usually, in most models, these two issues are not or poorly connected. However, since a natural dark matter candidate is a weakly interacting massive particle or WIMP, with mass around the electroweak scale, it is clearly of interest to investigate the possibility that DM and EWSB are closely related. In the context of a very simple extension of the Standard Model, the Inert Doublet Model, we show that dark matter could play a crucial role in the breaking of the electroweak symmetry. In this model, dark matter is the lightest component of an inert scalar doublet which can induce dynamically electroweak symmetry breaking at one loop level. Moreover, in a large fraction of the parameter space of this model, the mass of the dark matter particle is essentially determined by the electroweak scale, so that the fact that the WIMP DM mass is around the electroweak scale is not a coincidence.

  10. Searches for Dark Matter in events with long-lived particles at the LHC

    CERN Document Server

    Schioppa, Marco; The ATLAS collaboration

    2017-01-01

    The ATLAS, CMS and LHCb collaborations searched for Dark Matter (DM) in events with long-lived particles. Many theories of physics beyond the Standard Model predict the existence of stable, neutral, weakly-interacting and massive particles that are putative Dark Matter candidates. The observation of such matter at a collider could only establish that it is neutral, weakly-interactive, massive and stable on the distance-scales of tens of meters. The searches are performed using the LHC Run-I and Run-II datasets recorded with the ATLAS, CMS and LHCb detectors in proton-proton collisions at a center-of-mass energy of 7, 8 and 13 TeV. Signatures include both long-lived particles produced in association with DM and long-lived DM particles (e.g. dark photons decay in lepton-jets). This presentation covers only some of the many researches carried out with the LHC experiments in recent years. No deviation from SM background expectation was found up to now and exclusion limits on DM production cross section were set.

  11. Remobilization of Dry Matter, Nitrogen and Phosphorus in Durum Wheat as Affected by Genotype and Environment

    Directory of Open Access Journals (Sweden)

    Silvia Pampana

    2007-09-01

    Full Text Available Field studies were carried out to determine dry matter (DM, nitrogen (N and phosphorus (P assimilation until anthesis and DM, N and P remobilization during grain filling in wheat. Twentyfive durum wheat (Triticum durum L. varieties were grown in Tuscany at Grosseto and at Arezzo. At Grosseto 76% of DM was assimilated during pre-anthesis while at Arezzo the amount was 81%. At Grosseto 44% and at Arezzo 35% of N was accumulated until anthesis, while 33% of P was stored until anthesis in both localities. Cultivar differences in DM and N remobilization were positively related to pre-anthesis dry matter and N content at anthesis (r > 0.74. Environmental contraints on carbon, N and P availability in the plant are crucial factors in determining grain yield and N and P content in grain, affecting both accumulation and remobilization. In the low rainfall site of Grosseto, most of the grain yield originated from dry matter accumulation, while in the wetter environment of Arezzo remobilization and accumulation contributed equally to grain yield. Conversely, at Grosseto grain N content relied most on remobilization and at Arezzo remobilization and accumulation contributed equally. Finally, at Grosseto and at Arezzo accumulation of P was the main source of grain P content.

  12. MACHe3: A new generation detector for non-baryonic dark matter direct detection

    International Nuclear Information System (INIS)

    Santos, D.; Mayet, F.; Perrin, G.; Moulin, E.; Bunkov, Yu. M.; Godfrin, H.; Krusius, M.

    2002-01-01

    MACHe3 (MAtrix of Cells of superfluid 3 H e) is a project of a new detector for direct Dark Matter (DM) search, using superfluid 3 He as a sensitive medium. An experiment on a prototype cell has been performed and the st results reported here are encouraging to develop of a multicell prototype. In order to investigate the discovery potential of MACHe3, and its complementarity with other DM detectors, a phenomenological study done with the DarkSUSY code is shown. (authors)

  13. Production of extra quarks decaying to dark matter beyond the narrow width approximation at the LHC

    Science.gov (United States)

    Moretti, Stefano; O'Brien, Dermot; Panizzi, Luca; Prager, Hugo

    2017-08-01

    This paper explores the effects of finite width in processes of pair production of an extra heavy quark with charge 2 /3 (top partner) and its subsequent decay into a bosonic dark matter (DM) candidate—either scalar or vector—and SM up-type quarks at the Large Hadron Collider (LHC). This dynamics has been ignored so far in standard experimental searches of heavy quarks decaying to DM and we assess herein the regions of validity of current approaches, based on the assumption that the extra quarks have a narrow width. Further, we discuss the configurations of masses, widths and couplings where the latter breaks down.

  14. Matter power spectrum in hidden neutrino interacting dark matter models: a closer look at the collision term

    Energy Technology Data Exchange (ETDEWEB)

    Binder, Tobias; Covi, Laura [Institute for Theoretical Physics, Georg-August University Göttingen,Friedrich-Hund-Platz 1, Göttingen, D-37077 (Germany); Kamada, Ayuki [Department of Physics and Astronomy, University of California,Riverside, California 92521 (United States); Murayama, Hitoshi [Kavli Institute for the Physics and Mathematics of the Universe (WPI),University of Tokyo Institutes for Advanced Study, University of Tokyo,Kashiwa 277-8583 (Japan); Department of Physics, University of California, Berkeley,Berkeley, California 94720 (United States); Theoretical Physics Group, Lawrence Berkeley National Laboratory,Berkeley, California 94720 (United States); Takahashi, Tomo [Department of Physics, Saga University,Saga 840-8502 (Japan); Yoshida, Naoki [Kavli Institute for the Physics and Mathematics of the Universe (WPI),University of Tokyo Institutes for Advanced Study, University of Tokyo,Kashiwa 277-8583 (Japan); Department of Physics, University of Tokyo,Tokyo 113-0033 (Japan); CREST, Japan Science and Technology Agency,4-1-8 Honcho, Kawaguchi, Saitama, 332-0012 (Japan)

    2016-11-21

    Dark Matter (DM) models providing possible alternative solutions to the small-scale crisis of the standard cosmology are nowadays of growing interest. We consider DM interacting with light hidden fermions via well-motivated fundamental operators showing the resultant matter power spectrum is suppressed on subgalactic scales within a plausible parameter region. Our basic description of the evolution of cosmological perturbations relies on a fully consistent first principles derivation of a perturbed Fokker-Planck type equation, generalizing existing literature. The cosmological perturbation of the Fokker-Planck equation is presented for the first time in two different gauges, where the results transform into each other according to the rules of gauge transformation. Furthermore, our focus lies on a derivation of a broadly applicable and easily computable collision term showing important phenomenological differences to other existing approximations. As one of the main results and concerning the small-scale crisis, we show the equal importance of vector and scalar boson mediated interactions between the DM and the light fermions.

  15. An argument that the dark matter is axions

    International Nuclear Information System (INIS)

    Sikivie, P.

    2014-01-01

    An argument is presented that the dark matter is axions, at least in part. It has 3 steps. First, axions behave differently from the other forms of cold dark matter because they form a re-thermalizing Bose-Einstein condensate (BEC)). Second, there is a tool to distinguish axion BEC from the other dark matter candidates on the basis of observation, namely the study of the inner caustics of galactic halos. Third, the observational evidence for caustic rings of dark matter is consistent in every aspect with axion BEC, but not with the other proposed forms of dark matter. (author)

  16. Nurbayev D.M. Public and dispositive segments of abuse of the subjective right: interdisciplinary look.

    Directory of Open Access Journals (Sweden)

    Vladimir Azarov

    2017-01-01

    Full Text Available УДК 343.12The subject. The article is devoted to the analysis of a phenomenon "abuse of the right" from a position of the public and dispositive beginnings of his manifestation.The purpose of this article is to consider public and dispositive principles of abuse of the right in the scope of legal theory to qualify this phenomenon in criminal proceedings properly.Methodology. The author use methods of theoretical analysis and interdisciplinary approach as well as legal methods, including formal legal method and comparative law.Results, scope of it’s application. The authors note that the use of the advantages offered by abuse of the right is initially inherent only for the defending party in criminal proceedings.Abuse of the right in the procedural segment of disposition appears in the implementation of the right to protection in the criminal procedure as well as in the implementation of almost any rights in the civil proceedings.The main resource of publicity is realized exclusively by the courts in the civil procedure as well as by all government entities and officials in the criminal process. That’s why abuse of the right is interdicted by the activity of the court in civil procedure.The imperative method of legal regulation of public relations, that is the basis of publicity, is in fact one of the ways of prevention and suppression of abuse of rights. The disposition method, that is the basis of competition in legal relations, is a catalyst for the creation of situations of possible abuse of rights.Abuse of rights is manifested first and foremost in terms of the disposition, moreover – the higher the level of disposition in the particular branch of law provokes the greater likelihood of abuse of the right. Publicity limits disposition and, therefore, the possibility of abuse of the right.Conclusions. Legal institute of abuse of right requires early normative entrenchment in the criminal process. It should contain specific grounds for

  17. Conducting compositions of matter

    Science.gov (United States)

    Viswanathan, Tito (Inventor)

    2000-01-01

    The invention provides conductive compositions of matter, as well as methods for the preparation of the conductive compositions of matter, solutions comprising the conductive compositions of matter, and methods of preparing fibers or fabrics having improved anti-static properties employing the conductive compositions of matter.

  18. Asymmetric dark matter and CP violating scatterings in a UV complete model

    Energy Technology Data Exchange (ETDEWEB)

    Baldes, Iason; Bell, Nicole F.; Millar, Alexander J.; Volkas, Raymond R. [ARC Centre of Excellence for Particle Physics at the Terascale,School of Physics, The University of Melbourne, Victoria, 3010 (Australia)

    2015-10-21

    We explore possible asymmetric dark matter models using CP violating scatterings to generate an asymmetry. In particular, we introduce a new model, based on DM fields coupling to the SM Higgs and lepton doublets, a neutrino portal, and explore its UV completions. We study the CP violation and asymmetry formation of this model, to demonstrate that it is capable of producing the correct abundance of dark matter and the observed matter-antimatter asymmetry. Crucial to achieving this is the introduction of interactions which violate CP with a T{sup 2} dependence.

  19. Asymmetric dark matter and CP violating scatterings in a UV complete model

    Energy Technology Data Exchange (ETDEWEB)

    Baldes, Iason; Bell, Nicole F.; Millar, Alexander J.; Volkas, Raymond R., E-mail: i.baldes@student.unimelb.edu.au, E-mail: n.bell@unimelb.edu.au, E-mail: amillar@student.unimelb.edu.au, E-mail: raymondv@unimelb.edu.au [ARC Centre of Excellence for Particle Physics at the Terascale, School of Physics, The University of Melbourne, Victoria, 3010 Australia (Australia)

    2015-10-01

    We explore possible asymmetric dark matter models using CP violating scatterings to generate an asymmetry. In particular, we introduce a new model, based on DM fields coupling to the SM Higgs and lepton doublets, a neutrino portal, and explore its UV completions. We study the CP violation and asymmetry formation of this model, to demonstrate that it is capable of producing the correct abundance of dark matter and the observed matter-antimatter asymmetry. Crucial to achieving this is the introduction of interactions which violate CP with a T{sup 2} dependence.

  20. On thermal gravitational contribution to particle production and dark matter

    Directory of Open Access Journals (Sweden)

    Yong Tang

    2017-11-01

    Full Text Available We investigate the particle production from thermal gravitational annihilation in the very early universe, which is an important contribution for particles that might not be in thermal equilibrium or/and might only have gravitational interaction, such as dark matter (DM. For particles with spin 0,1/2 and 1 we calculate the relevant cross sections through gravitational annihilation and give the analytic formulas with full mass-dependent terms. We find that DM with mass between TeV and 1016 GeV could have the relic abundance that fits the observation, with small dependence on its spin. We also discuss the effects of gravitational annihilation from inflatons. Interestingly, contributions from inflatons could be dominant and have the same power dependence on Hubble parameter of inflation as that from vacuum fluctuation. Also, fermion production from inflaton, in comparison to boson, is suppressed by its mass due to helicity selection.