SU-E-T-225: Correction Matrix for PinPoint Ionization Chamber for Dosimetric Measurements in the Newly Released Incise™ Multileaf Collimator Shaped Small Field for CyberKnife M6™ Machine

Energy Technology Data Exchange (ETDEWEB)

Zhang, Y; Li, T; Heron, D; Huq, M [University of Pittsburgh Cancer Institute and UPMC CancerCenter, Pittsburgh, PA (United States)

2015-06-15

Purpose: For small field dosimetry, such as measurements of output factors for cones or MLC-shaped irregular small fields, ion chambers often Result in an underestimation of the dose, due to both the volume averaging effect and the lack of lateral charged particle equilibrium. This work presents a mathematical model for correction matrix for a PTW PinPoint ionization chamber for dosimetric measurements made in the newly released Incise™ Multileaf collimator fields of the CyberKnife M6™ machine. Methods: A correction matrix for a PTW 0.015cc PinPoint ionization chamber was developed by modeling its 3D dose response in twelve cone-shaped circular fields created using the 5mm, 7.5mm, 10mm, 12.5mm, 15mm, 20mm, 25mm, 30mm, 35mm, 40mm, 50mm, 60mm cones in a CyberKnife M6™ machine. For each field size, hundreds of readings were recorded for every 2mm chamber shift in the horizontal plane. The contribution of each dose pixel to a measurement point depended on the radial distance and the angle to the chamber axis. These readings were then compared with the theoretical dose as obtained with Monte Carlo calculation. A penalized least-square optimization algorithm was developed to generate the correction matrix. After the parameter fitting, the mathematical model was validated for MLC-shaped irregular fields. Results: The optimization algorithm used for parameter fitting was stable and the resulted response factors were smooth in spatial domain. After correction with the mathematical model, the chamber reading matched with the calculation for all the tested fields to within 2%. Conclusion: A novel mathematical model has been developed for PinPoint chamber for dosimetric measurements in small MLC-shaped irregular fields. The correction matrix is dependent on detector, treatment unit and the geometry of setup. The model can be applied to non-standard composite fields and provides an access to IMRT point dose validation.

SU-E-T-225: Correction Matrix for PinPoint Ionization Chamber for Dosimetric Measurements in the Newly Released Incise™ Multileaf Collimator Shaped Small Field for CyberKnife M6™ Machine

International Nuclear Information System (INIS)

Zhang, Y; Li, T; Heron, D; Huq, M

2015-01-01

Purpose: For small field dosimetry, such as measurements of output factors for cones or MLC-shaped irregular small fields, ion chambers often Result in an underestimation of the dose, due to both the volume averaging effect and the lack of lateral charged particle equilibrium. This work presents a mathematical model for correction matrix for a PTW PinPoint ionization chamber for dosimetric measurements made in the newly released Incise™ Multileaf collimator fields of the CyberKnife M6™ machine. Methods: A correction matrix for a PTW 0.015cc PinPoint ionization chamber was developed by modeling its 3D dose response in twelve cone-shaped circular fields created using the 5mm, 7.5mm, 10mm, 12.5mm, 15mm, 20mm, 25mm, 30mm, 35mm, 40mm, 50mm, 60mm cones in a CyberKnife M6™ machine. For each field size, hundreds of readings were recorded for every 2mm chamber shift in the horizontal plane. The contribution of each dose pixel to a measurement point depended on the radial distance and the angle to the chamber axis. These readings were then compared with the theoretical dose as obtained with Monte Carlo calculation. A penalized least-square optimization algorithm was developed to generate the correction matrix. After the parameter fitting, the mathematical model was validated for MLC-shaped irregular fields. Results: The optimization algorithm used for parameter fitting was stable and the resulted response factors were smooth in spatial domain. After correction with the mathematical model, the chamber reading matched with the calculation for all the tested fields to within 2%. Conclusion: A novel mathematical model has been developed for PinPoint chamber for dosimetric measurements in small MLC-shaped irregular fields. The correction matrix is dependent on detector, treatment unit and the geometry of setup. The model can be applied to non-standard composite fields and provides an access to IMRT point dose validation

SENSITIVITY TEMPERATURE DEPENDENCE RESEARCH OF TV-CAMERAS BASED ON SILICON MATRIXES

Directory of Open Access Journals (Sweden)

Alexey N. Starchenko

2017-07-01

Full Text Available Subject of Research. The research is dedicated to the analysis of sensitivity change patterns of the cameras based on silicon CMOS-matrixes in various ambient temperatures. This information is necessary for the correct camera application for photometric measurements in-situ. The paper deals with studies of sensitivity variations of two digital cameras with different silicon CMOS matrixes in visible and near IR regions of the spectrum at temperature change. Method. Due to practical restrictions the temperature changes were recorded in separate spectral intervals important for practical use of the cameras. The experiments were carried out with the use of a climatic chamber, providing change and keeping the temperature range from minus 40 to plus 50 °C at a pitch of 10 о С. Two cameras were chosen for research: VAC-135-IP with OmniVision OV9121 matrix and VAC-248-IP with OnSemiconductor VITA2000 matrix. The two tested devices were placed in a climatic chamber at the same time and illuminated by one radiation source with a color temperature about 3000 K in order to eliminate a number of methodological errors. Main Results. The temperature dependence of the signals was shown to be linear and the matrixes sensitivities were determined. The results obtained are consistent with theoretical views, in general. The coefficients of thermal sensitivity were computed by these dependencies. It is shown that the greatest affect of temperature on the sensitivity occurs in the area (0.7–1.1 mkm. Temperature coefficients of sensitivity increase with the downward radiation wavelength increase. The experiments carried out have shown that it is necessary to take into account the changes in temperature sensitivity of silicon matrixes in the red and near in IR regions of the spectrum. The effect reveals itself in a clearly negative way in cameras with an amplitude resolution of 10-12 bits used for aerospace and space spectrozonal photography. Practical Relevance

Interface discontinuity factors in the modal Eigenspace of the multigroup diffusion matrix

International Nuclear Information System (INIS)

Garcia-Herranz, N.; Herrero, J.J.; Cuervo, D.; Ahnert, C.

2011-01-01

Interface discontinuity factors based on the Generalized Equivalence Theory are commonly used in nodal homogenized diffusion calculations so that diffusion average values approximate heterogeneous higher order solutions. In this paper, an additional form of interface correction factors is presented in the frame of the Analytic Coarse Mesh Finite Difference Method (ACMFD), based on a correction of the modal fluxes instead of the physical fluxes. In the ACMFD formulation, implemented in COBAYA3 code, the coupled multigroup diffusion equations inside a homogenized region are reduced to a set of uncoupled modal equations through diagonalization of the multigroup diffusion matrix. Then, physical fluxes are transformed into modal fluxes in the Eigenspace of the diffusion matrix. It is possible to introduce interface flux discontinuity jumps as the difference of heterogeneous and homogeneous modal fluxes instead of introducing interface discontinuity factors as the ratio of heterogeneous and homogeneous physical fluxes. The formulation in the modal space has been implemented in COBAYA3 code and assessed by comparison with solutions using classical interface discontinuity factors in the physical space. (author)

ARMA Cholesky Factor Models for the Covariance Matrix of Linear Models.

Science.gov (United States)

Lee, Keunbaik; Baek, Changryong; Daniels, Michael J

2017-11-01

In longitudinal studies, serial dependence of repeated outcomes must be taken into account to make correct inferences on covariate effects. As such, care must be taken in modeling the covariance matrix. However, estimation of the covariance matrix is challenging because there are many parameters in the matrix and the estimated covariance matrix should be positive definite. To overcomes these limitations, two Cholesky decomposition approaches have been proposed: modified Cholesky decomposition for autoregressive (AR) structure and moving average Cholesky decomposition for moving average (MA) structure, respectively. However, the correlations of repeated outcomes are often not captured parsimoniously using either approach separately. In this paper, we propose a class of flexible, nonstationary, heteroscedastic models that exploits the structure allowed by combining the AR and MA modeling of the covariance matrix that we denote as ARMACD. We analyze a recent lung cancer study to illustrate the power of our proposed methods.

Clonorchis sinensis excretory-secretory products regulate migration and invasion in cholangiocarcinoma cells via extracellular signal-regulated kinase 1/2/nuclear factor-κB-dependent matrix metalloproteinase-9 expression.

Science.gov (United States)

Pak, Jhang Ho; Shin, Jimin; Song, In-Sung; Shim, Sungbo; Jang, Sung-Wuk

2017-01-01

Matrix metalloproteinase-9 plays an important role in the invasion and metastasis of various types of cancer cells. We have previously reported that excretory-secretory products from Clonorchis sinensis increases matrix metalloproteinase-9 expression. However, the regulatory mechanisms through which matrix metalloproteinase-9 expression affects cholangiocarcinoma development remain unclear. In the current study, we examined the potential role of excretory-secretory products in regulating the migration and invasion of various cholangiocarcinoma cell lines. We demonstrated that excretory-secretory products significantly induced matrix metalloproteinase-9 expression and activity in a concentration-dependent manner. Reporter gene and chromatin immunoprecipitation assays showed that excretory-secretory products induced matrix metalloproteinase-9 expression by enhancing the activity of nuclear factor-kappa B. Moreover, excretory-secretory products induced the degradation and phosphorylation of IκBα and stimulated nuclear factor-kappa B p65 nuclear translocation, which was regulated by extracellular signal-regulated kinase 1/2. Taken together, our findings indicated that the excretory-secretory product-dependent enhancement of matrix metalloproteinase-9 activity and subsequent induction of IκBα and nuclear factor-kappa B activities may contribute to the progression of cholangiocarcinoma. Copyright © 2016 Australian Society for Parasitology. Published by Elsevier Ltd. All rights reserved.

Scatter factor corrections for elongated fields

International Nuclear Information System (INIS)

Higgins, P.D.; Sohn, W.H.; Sibata, C.H.; McCarthy, W.A.

1989-01-01

Measurements have been made to determine scatter factor corrections for elongated fields of Cobalt-60 and for nominal linear accelerator energies of 6 MV (Siemens Mevatron 67) and 18 MV (AECL Therac 20). It was found that for every energy the collimator scatter factor varies by 2% or more as the field length-to-width ratio increases beyond 3:1. The phantom scatter factor is independent of which collimator pair is elongated at these energies. For 18 MV photons it was found that the collimator scatter factor is complicated by field-size-dependent backscatter into the beam monitor

Matrix effects of TRU [transuranic] assays using the SWEPP PAN assay system

International Nuclear Information System (INIS)

Smith, J.R.

1990-08-01

The Drum Assay System (DAS) at the Stored Waste Experimental Pilot Plant (SWEPP) is a second-generation active-passive neutron assay system. It has been used to assay over 5000 208-liter drums of transuranic waste from the Rocky Flats Plant (RFP). Data from these assays have been examined and compared with the assays performed at Rocky Flats, mainly utilize counting of 239 Pu gamma rays. For the most part the passive assays are in very good agreement with the Rocky Flats assays. The active assays are strongly correlated with the results of the other two methods, but require matrix-dependent correction factors beyond those provided by the system itself. A set of matrix-dependent correction factors has been developed from the study of the assay results. 3 refs., 4 figs., 3 tabs

Integral transport multiregion geometrical shadowing factor for the approximate collision probability matrix calculation of infinite closely packed lattices

International Nuclear Information System (INIS)

Jowzani-Moghaddam, A.

1981-01-01

An integral transport method of calculating the geometrical shadowing factor in multiregion annular cells for infinite closely packed lattices in cylindrical geometry is developed. This analytical method has been programmed in the TPGS code. This method is based upon a consideration of the properties of the integral transport method for a nonuniform body, which together with Bonalumi's approximations allows the determination of the approximate multiregion collision probability matrix for infinite closely packed lattices with sufficient accuracy. The multiregion geometrical shadowing factors have been calculated for variations in fuel pin annular segment rings in a geometry of annular cells. These shadowing factors can then be used in the calculation of neutron transport from one annulus to another in an infinite lattice. The result of this new geometrical shadowing and collision probability matrix are compared with the Dancoff-Ginsburg correction and the probability matrix using constant shadowing on Yankee fuel elements in an infinite lattice. In these cases the Dancoff-Ginsburg correction factor and collision probability matrix using constant shadowing are in difference by at most 6.2% and 6%, respectively

Matrix completion by deep matrix factorization.

Science.gov (United States)

Fan, Jicong; Cheng, Jieyu

2018-02-01

Conventional methods of matrix completion are linear methods that are not effective in handling data of nonlinear structures. Recently a few researchers attempted to incorporate nonlinear techniques into matrix completion but there still exists considerable limitations. In this paper, a novel method called deep matrix factorization (DMF) is proposed for nonlinear matrix completion. Different from conventional matrix completion methods that are based on linear latent variable models, DMF is on the basis of a nonlinear latent variable model. DMF is formulated as a deep-structure neural network, in which the inputs are the low-dimensional unknown latent variables and the outputs are the partially observed variables. In DMF, the inputs and the parameters of the multilayer neural network are simultaneously optimized to minimize the reconstruction errors for the observed entries. Then the missing entries can be readily recovered by propagating the latent variables to the output layer. DMF is compared with state-of-the-art methods of linear and nonlinear matrix completion in the tasks of toy matrix completion, image inpainting and collaborative filtering. The experimental results verify that DMF is able to provide higher matrix completion accuracy than existing methods do and DMF is applicable to large matrices. Copyright © 2017 Elsevier Ltd. All rights reserved.

Quadrupole corrections to matrix elements of transitions in resonant reactions of muonic molecule formation

International Nuclear Information System (INIS)

Faifman, M.P.; Strizh, T.A.; Armour, E.A.G.; Harston, M.R.

1996-01-01

The calculated resonant formation rates of the muonic molecules DDμ and DTμ are presented. The approach developed earlier for calculating the transition matrix elements in the dipole approximation has been extended to include the quadrupole terms in the multipole expansion of the interaction operator. The calculated dependence of the DTμ formation rates on the energies of the incident Tμ muonic atoms shows that the effect of including the quadrupole correction is to reduce the magnitude of the peak rates by about 20-30% at the different temperatures, compared to those calculated in the dipole approximation. The dependence on temperature for the DDμ formation rates is obtained with the differences between the presented and previous calculations being less than 5%. (orig.)

Physical matrix correction for RFA of mass and special glasses

International Nuclear Information System (INIS)

Medicus, G.; Ritter, R.

1984-01-01

A theoretical matrix correction model with relatively complex mass absorption coefficients is reported, which takes into account the adsorption of the stimulating radiation and the radiation in the specimen to be measured, as well as the geometry of the spectrometer. With the realized concept of an effective primary wave length, good correction results were obtained over large regions of concentrations and elements. The computer program renders possible besides of the usual reference measurement at uniform reference wave length - the reference of several elements in the specimen to one special element of the reference specimen. The correction method was tested with 42 test glasses, which were previously analyzed. (author)

1/mQ corrections to form factors and extraction of |Vcb|

International Nuclear Information System (INIS)

Liu, J.; Chao, K.

1997-01-01

Form factors for 0 - →0 - and 0 - →1 - mesonic transitions in the heavy quark limit and the 1/m Q corrections are analyzed model independently within the Bethe-Salpeter (BS) formalism. The analysis shows that the BS formalism has spin-flavor symmetry in the heavy quark limit and respects Luke's theorem when the 1/m Q corrections are taken into account. All form factors for B→D (*) transitions beyond the zero recoil point are estimated in a relativistic constituent quark model based on the BS formalism. Using these form factors we calculate the branching ratios for the semileptonic decays B→D (*) l + ν l and extract the Cabibbo-Kobayashi-Maskawa matrix element |V cb |. We get |V cb |=0.042±0.003 which is consistent with the current world average. copyright 1997 The American Physical Society

A bias correction for covariance estimators to improve inference with generalized estimating equations that use an unstructured correlation matrix.

Science.gov (United States)

Westgate, Philip M

2013-07-20

Generalized estimating equations (GEEs) are routinely used for the marginal analysis of correlated data. The efficiency of GEE depends on how closely the working covariance structure resembles the true structure, and therefore accurate modeling of the working correlation of the data is important. A popular approach is the use of an unstructured working correlation matrix, as it is not as restrictive as simpler structures such as exchangeable and AR-1 and thus can theoretically improve efficiency. However, because of the potential for having to estimate a large number of correlation parameters, variances of regression parameter estimates can be larger than theoretically expected when utilizing the unstructured working correlation matrix. Therefore, standard error estimates can be negatively biased. To account for this additional finite-sample variability, we derive a bias correction that can be applied to typical estimators of the covariance matrix of parameter estimates. Via simulation and in application to a longitudinal study, we show that our proposed correction improves standard error estimation and statistical inference. Copyright © 2012 John Wiley & Sons, Ltd.

Non-negative Matrix Factorization for Binary Data

DEFF Research Database (Denmark)

Larsen, Jacob Søgaard; Clemmensen, Line Katrine Harder

We propose the Logistic Non-negative Matrix Factorization for decomposition of binary data. Binary data are frequently generated in e.g. text analysis, sensory data, market basket data etc. A common method for analysing non-negative data is the Non-negative Matrix Factorization, though...... this is in theory not appropriate for binary data, and thus we propose a novel Non-negative Matrix Factorization based on the logistic link function. Furthermore we generalize the method to handle missing data. The formulation of the method is compared to a previously proposed method (Tome et al., 2015). We compare...... the performance of the Logistic Non-negative Matrix Factorization to Least Squares Non-negative Matrix Factorization and Kullback-Leibler (KL) Non-negative Matrix Factorization on sets of binary data: a synthetic dataset, a set of student comments on their professors collected in a binary term-document matrix...

Perturbative corrections to B → D form factors in QCD

Science.gov (United States)

Wang, Yu-Ming; Wei, Yan-Bing; Shen, Yue-Long; Lü, Cai-Dian

2017-06-01

We compute perturbative QCD corrections to B → D form factors at leading power in Λ/ m b , at large hadronic recoil, from the light-cone sum rules (LCSR) with B-meson distribution amplitudes in HQET. QCD factorization for the vacuum-to- B-meson correlation function with an interpolating current for the D-meson is demonstrated explicitly at one loop with the power counting scheme {m}_c˜ O(√{Λ {m}_b}) . The jet functions encoding information of the hard-collinear dynamics in the above-mentioned correlation function are complicated by the appearance of an additional hard-collinear scale m c , compared to the counterparts entering the factorization formula of the vacuum-to- B-meson correction function for the construction of B → π from factors. Inspecting the next-to-leading-logarithmic sum rules for the form factors of B → Dℓν indicates that perturbative corrections to the hard-collinear functions are more profound than that for the hard functions, with the default theory inputs, in the physical kinematic region. We further compute the subleading power correction induced by the three-particle quark-gluon distribution amplitudes of the B-meson at tree level employing the background gluon field approach. The LCSR predictions for the semileptonic B → Dℓν form factors are then extrapolated to the entire kinematic region with the z-series parametrization. Phenomenological implications of our determinations for the form factors f BD +,0 ( q 2) are explored by investigating the (differential) branching fractions and the R( D) ratio of B → Dℓν and by determining the CKM matrix element |V cb | from the total decay rate of B → Dμν μ .

Next to Leading Order QCD Corrections to Polarized $\\Lambda$ Production in DIS

CERN Document Server

de Florian, D

1997-01-01

We calculate next to leading order QCD corrections to semi-inclusive polarized deep inelastic scattering and $e^+e^-$ annihilation cross sections for processes where the polarization of the identified final-state hadron can also be determined. Using dimensional regularization and the HVBM prescription for the $\\gamma_5$ matrix, we compute corrections for different spin-dependent observables, both in the $\\overline{MS}$ and $\\overline{MS_p}$ factorization schemes, and analyse their structure. In addition to the well known corrections to polarized parton distributions, we also present those for final-state polarized fracture functions and polarized fragmentation functions, in a consistent factorization scheme.

ON-LINE NONLINEAR CHROMATICITY CORRECTION USING OFF-MOMENTUM TUNE RESPONSE MATRIX

International Nuclear Information System (INIS)

LUO, Y.; FISCHER, W.; MALISKY, N.; TEPIKIAN, S.; TROBJEVIC, D.

2007-01-01

In this article, we propose a method for the online nonlinear chromaticity correction at store in the Relativistic Heavy Ion Collider (RHIC). With 8 arc sextupole families in each RHIC ring, the nonlinear chromaticities can be minimized online by matching the off-momentum tunes onto the wanted tunes given by the linear chromaticities. The Newton method is used for this multi-dimensional nonlinear optimization, where the off-momentum tune response matrix with respect to sextupole strength changes is adopted. The off-momentum tune response matrix can be calculated with the online accelerator optics model or directly measured with the real beam. In this article, the correction algorithm for the RHIC is presented. Simulations are also carried out to verify the method. The preliminary results from the beam experiments taken place in the RHIC 2007 Au run are reviewed

An Uncertainty Structure Matrix for Models and Simulations

Science.gov (United States)

Green, Lawrence L.; Blattnig, Steve R.; Hemsch, Michael J.; Luckring, James M.; Tripathi, Ram K.

2008-01-01

Software that is used for aerospace flight control and to display information to pilots and crew is expected to be correct and credible at all times. This type of software is typically developed under strict management processes, which are intended to reduce defects in the software product. However, modeling and simulation (M&S) software may exhibit varying degrees of correctness and credibility, depending on a large and complex set of factors. These factors include its intended use, the known physics and numerical approximations within the M&S, and the referent data set against which the M&S correctness is compared. The correctness and credibility of an M&S effort is closely correlated to the uncertainty management (UM) practices that are applied to the M&S effort. This paper describes an uncertainty structure matrix for M&S, which provides a set of objective descriptions for the possible states of UM practices within a given M&S effort. The columns in the uncertainty structure matrix contain UM elements or practices that are common across most M&S efforts, and the rows describe the potential levels of achievement in each of the elements. A practitioner can quickly look at the matrix to determine where an M&S effort falls based on a common set of UM practices that are described in absolute terms that can be applied to virtually any M&S effort. The matrix can also be used to plan those steps and resources that would be needed to improve the UM practices for a given M&S effort.

Spatial correction factors for YALINA Booster facility loaded with medium and low enriched fuels

International Nuclear Information System (INIS)

Talamo, A.; Gohar, Y.; Bournos, V.; Fokov, Y.; Kiyavitskaya, H.; Routkovskaya, C.

2012-01-01

The Bell and Glasstone spatial correction factor is used in analyses of subcritical assemblies to correct the experimental reactivity as function of the detector position. Besides the detector position, several other parameters affect the correction factor: the energy weighting function of the detector, the detector size, the energy-angle distribution of source neutrons, and the reactivity of the subcritical assembly. This work focuses on the dependency of the correction factor on the detector material and it investigates the YALINA Booster subcritical assembly loaded with medium (36%) and low (10%) enriched fuels. (authors)

Spatial correction factors for YALINA Booster facility loaded with medium and low enriched fuels

Energy Technology Data Exchange (ETDEWEB)

Talamo, A.; Gohar, Y. [Argonne National Laboratory, 9700 S. Cass Ave, Argonne, IL 60439 (United States); Bournos, V.; Fokov, Y.; Kiyavitskaya, H.; Routkovskaya, C. [Joint Inst. for Power and Nuclear Research-Sosny, 99 Academician A.K.Krasin Str, Minsk 220109 (Belarus)

2012-07-01

The Bell and Glasstone spatial correction factor is used in analyses of subcritical assemblies to correct the experimental reactivity as function of the detector position. Besides the detector position, several other parameters affect the correction factor: the energy weighting function of the detector, the detector size, the energy-angle distribution of source neutrons, and the reactivity of the subcritical assembly. This work focuses on the dependency of the correction factor on the detector material and it investigates the YALINA Booster subcritical assembly loaded with medium (36%) and low (10%) enriched fuels. (authors)

Multi-site Field Verification of Laboratory Derived FDOM Sensor Corrections: The Good, the Bad and the Ugly

Science.gov (United States)

Saraceno, J.; Shanley, J. B.; Aulenbach, B. T.

2014-12-01

Fluorescent dissolved organic matter (FDOM) is an excellent proxy for dissolved organic carbon (DOC) in natural waters. Through this relationship, in situ FDOM can be utilized to capture both high frequency time series and long term fluxes of DOC in small streams. However, in order to calculate accurate DOC fluxes for comparison across sites, in situ FDOM data must be compensated for matrix effects. Key matrix effects, include temperature, turbidity and the inner filter effect due to color. These interferences must be compensated for to develop a reasonable relationship between FDOM and DOC. In this study, we applied laboratory-derived correction factors to real time data from the five USGS WEBB headwater streams in order to gauge their effectiveness across a range of matrix effects. The good news is that laboratory derived correction factors improved the predicative relationship (higher r2) between DOC and FDOM when compared to uncorrected data. The relative importance of each matrix effect (i.e. temperature) varied by site and by time, implying that each and every matrix effect should be compensated for when available. In general, temperature effects were more important on longer time scales, while corrections for turbidity and DOC inner filter effects were most prevalent during hydrologic events, when the highest instantaneous flux of DOC occurred. Unfortunately, even when corrected for matrix effects, in situ FDOM is a weaker predictor of DOC than A254, a common surrogate for DOC, implying that either DOC fluoresces at varying degrees (but should average out over time), that some matrix effects (e.g. pH) are either unaccounted for or laboratory-derived correction factors do not encompass the site variability of particles and organics. The least impressive finding is that the inherent dependence on three variables in the FDOM correction algorithm increases the likelihood of record data gaps which increases the uncertainty in calculated DOC flux values.

Automatic Power Factor Correction Using Capacitive Bank

OpenAIRE

Mr.Anant Kumar Tiwari,; Mrs. Durga Sharma

2014-01-01

The power factor correction of electrical loads is a problem common to all industrial companies. Earlier the power factor correction was done by adjusting the capacitive bank manually [1]. The automated power factor corrector (APFC) using capacitive load bank is helpful in providing the power factor correction. Proposed automated project involves measuring the power factor value from the load using microcontroller. The design of this auto-adjustable power factor correction is ...

Separation of soft and collinear infrared limits of QCD squared matrix elements

CERN Document Server

Nagy, Zoltan; Trócsányi, Z L; Trocsanyi, Zoltan; Somogyi, Gabor; Trocsanyi, Zoltan

2007-01-01

We present a simple way of separating the overlap between the soft and collinear factorization formulae of QCD squared matrix elements. We check its validity explicitly for single and double unresolved emissions of tree-level processes. The new method makes possible the definition of helicity-dependent subtraction terms for regularizing the real contributions in computing radiative corrections to QCD jet cross sections. This implies application of Monte Carlo helicity summation in computing higher order corrections.

Correction factors for clinical dosemeters used in large field dosimetry

International Nuclear Information System (INIS)

Campos, L.L.; Caldas, L.

1989-08-01

The determination of the absorbed dose in high-energy photon and electron beams by the user is carried out as a two-step procedure. First the ionization chamber is calibrated at a reference quality by the user at a standard laboratory, and then the chamber is used to determine the absorbed dose with the user's beam. A number of conversion and correction factors have to be applied. Different sets of factors are needed depending on the physical quantity the calibration refers to, the calibration geometry and the chamber design. Another correction factor to be introduced for the absorbed dose determination in large fields refers to radiation effects on the stem, cable and sometimes connectors. A simple method was developed to be suggested to hospital physicists to be followed during large radiation field dosimetry, in order to evaluate the radiation effects of cables and connectors and to determine correction factors for each system or geometry. (author) [pt

The position dependent influence that sensitivity correction processing gives the signal-to-noise ratio measurement in parallel imaging

International Nuclear Information System (INIS)

Murakami, Koichi; Yoshida, Koji; Yanagimoto, Shinichi

2012-01-01

We studied the position dependent influence that sensitivity correction processing gave the signal-to-noise ratio (SNR) measurement of parallel imaging (PI). Sensitivity correction processing that referred to the sensitivity distribution of the body coil improved regional uniformity more than the sensitivity uniformity correction filter with a fixed correction factor. In addition, the position dependent influence to give the SNR measurement in PI was different from the sensitivity correction processing. Therefore, if we divide SNR of the sensitivity correction processing image by SNR of the original image in each pixel and calculate SNR ratio, we can show the position dependent influence that sensitivity correction processing gives the SNR measurement in PI. It is with an index of the sensitivity correction processing precision. (author)

An analytical X-ray CdTe detector response matrix for incomplete charge collection correction for photon energies up to 300 keV

Science.gov (United States)

Kurková, Dana; Judas, Libor

2018-05-01

Gamma and X-ray energy spectra measured with semiconductor detectors suffer from various distortions, one of them being so-called "tailing" caused by an incomplete charge collection. Using the Hecht equation, a response matrix of size 321 × 321 was constructed which was used to correct the effect of incomplete charge collection. The correction matrix was constructed analytically for an arbitrary energy bin and the size of the energy bin thus defines the width of the spectral window. The correction matrix can be applied separately from other possible spectral corrections or it can be incorporated into an already existing response matrix of the detector. The correction was tested and its adjustable parameters were optimized on the line spectra of 57Co measured with a cadmium telluride (CdTe) detector in a spectral range from 0 up to 160 keV. The best results were obtained when the values of the free path of holes were spread over a range from 0.4 to 1.0 cm and weighted by a Gauss function. The model with the optimized parameter values was then used to correct the line spectra of 152Eu in a spectral range from 0 up to 530 keV. An improvement in the energy resolution at full width at half maximum from 2.40 % ± 0.28 % to 0.96 % ± 0.28 % was achieved at 344.27 keV. Spectra of "narrow spectrum series" beams, N120, N150, N200, N250 and N300, generated with tube voltages of 120 kV, 150 kV, 200 kV, 250 kV and 300 kV respectively, and measured with the CdTe detector, were corrected in the spectral range from 0 to 160 keV (N120 and N150) and from 0 to 530 keV (N200, N250, N300). All the measured spectra correspond both qualitatively and quantitatively to the available reference data after the correction. To obtain better correspondence between N150, N200, N250 and N300 spectra and the reference data, lower values of the free paths of holes (range from 0.16 to 0.65 cm) were used for X-ray spectra correction, which suggests energy dependence of the phenomenon.

Convex nonnegative matrix factorization with manifold regularization.

Science.gov (United States)

Hu, Wenjun; Choi, Kup-Sze; Wang, Peiliang; Jiang, Yunliang; Wang, Shitong

2015-03-01

Nonnegative Matrix Factorization (NMF) has been extensively applied in many areas, including computer vision, pattern recognition, text mining, and signal processing. However, nonnegative entries are usually required for the data matrix in NMF, which limits its application. Besides, while the basis and encoding vectors obtained by NMF can represent the original data in low dimension, the representations do not always reflect the intrinsic geometric structure embedded in the data. Motivated by manifold learning and Convex NMF (CNMF), we propose a novel matrix factorization method called Graph Regularized and Convex Nonnegative Matrix Factorization (GCNMF) by introducing a graph regularized term into CNMF. The proposed matrix factorization technique not only inherits the intrinsic low-dimensional manifold structure, but also allows the processing of mixed-sign data matrix. Clustering experiments on nonnegative and mixed-sign real-world data sets are conducted to demonstrate the effectiveness of the proposed method. Copyright © 2014 Elsevier Ltd. All rights reserved.

General factorization relations and consistency conditions in the sudden approximation via infinite matrix inversion

International Nuclear Information System (INIS)

Chan, C.K.; Hoffman, D.K.; Evans, J.W.

1985-01-01

Local, i.e., multiplicative, operators satisfy well-known linear factorization relations wherein matrix elements (between states associated with a complete set of wave functions) can be obtained as a linear combination of those out of the ground state (the input data). Analytic derivation of factorization relations for general state input data results in singular integral expressions for the coefficients, which can, however, be regularized using consistency conditions between matrix elements out of a single (nonground) state. Similar results hold for suitable ''symmetry class'' averaged matrix elements where the symmetry class projection operators are ''complete.'' In several cases where the wave functions or projection operators incorporate orthogonal polynomial dependence, we show that the ground state factorization relations have a simplified structure allowing an alternative derivation of the general factorization relations via an infinite matrix inversion procedure. This form is shown to have some advantages over previous versions. In addition, this matrix inversion procedure obtains all consistency conditions (which is not always the case from regularization of singular integrals)

Fast matrix factorization algorithm for DOSY based on the eigenvalue decomposition and the difference approximation focusing on the size of observed matrix

International Nuclear Information System (INIS)

Tanaka, Yuho; Uruma, Kazunori; Furukawa, Toshihiro; Nakao, Tomoki; Izumi, Kenya; Utsumi, Hiroaki

2017-01-01

This paper deals with an analysis problem for diffusion-ordered NMR spectroscopy (DOSY). DOSY is formulated as a matrix factorization problem of a given observed matrix. In order to solve this problem, a direct exponential curve resolution algorithm (DECRA) is well known. DECRA is based on singular value decomposition; the advantage of this algorithm is that the initial value is not required. However, DECRA requires a long calculating time, depending on the size of the given observed matrix due to the singular value decomposition, and this is a serious problem in practical use. Thus, this paper proposes a new analysis algorithm for DOSY to achieve a short calculating time. In order to solve matrix factorization for DOSY without using singular value decomposition, this paper focuses on the size of the given observed matrix. The observed matrix in DOSY is also a rectangular matrix with more columns than rows, due to limitation of the measuring time; thus, the proposed algorithm transforms the given observed matrix into a small observed matrix. The proposed algorithm applies the eigenvalue decomposition and the difference approximation to the small observed matrix, and the matrix factorization problem for DOSY is solved. The simulation and a data analysis show that the proposed algorithm achieves a lower calculating time than DECRA as well as similar analysis result results to DECRA. (author)

SU-E-T-469: A Practical Approach for the Determination of Small Field Output Factors Using Published Monte Carlo Derived Correction Factors

International Nuclear Information System (INIS)

Calderon, E; Siergiej, D

2014-01-01

Purpose: Output factor determination for small fields (less than 20 mm) presents significant challenges due to ion chamber volume averaging and diode over-response. Measured output factor values between detectors are known to have large deviations as field sizes are decreased. No set standard to resolve this difference in measurement exists. We observed differences between measured output factors of up to 14% using two different detectors. Published Monte Carlo derived correction factors were used to address this challenge and decrease the output factor deviation between detectors. Methods: Output factors for Elekta's linac-based stereotactic cone system were measured using the EDGE detector (Sun Nuclear) and the A16 ion chamber (Standard Imaging). Measurements conditions were 100 cm SSD (source to surface distance) and 1.5 cm depth. Output factors were first normalized to a 10.4 cm × 10.4 cm field size using a daisy-chaining technique to minimize the dependence of field size on detector response. An equation expressing the relation between published Monte Carlo correction factors as a function of field size for each detector was derived. The measured output factors were then multiplied by the calculated correction factors. EBT3 gafchromic film dosimetry was used to independently validate the corrected output factors. Results: Without correction, the deviation in output factors between the EDGE and A16 detectors ranged from 1.3 to 14.8%, depending on cone size. After applying the calculated correction factors, this deviation fell to 0 to 3.4%. Output factors determined with film agree within 3.5% of the corrected output factors. Conclusion: We present a practical approach to applying published Monte Carlo derived correction factors to measured small field output factors for the EDGE and A16 detectors. Using this method, we were able to decrease the percent deviation between both detectors from 14.8% to 3.4% agreement

Invisible data matrix detection with smart phone using geometric correction and Hough transform

Science.gov (United States)

Sun, Halit; Uysalturk, Mahir C.; Karakaya, Mahmut

2016-04-01

Two-dimensional data matrices are used in many different areas that provide quick and automatic data entry to the computer system. Their most common usage is to automatically read labeled products (books, medicines, food, etc.) and recognize them. In Turkey, alcohol beverages and tobacco products are labeled and tracked with the invisible data matrices for public safety and tax purposes. In this application, since data matrixes are printed on a special paper with a pigmented ink, it cannot be seen under daylight. When red LEDs are utilized for illumination and reflected light is filtered, invisible data matrices become visible and decoded by special barcode readers. Owing to their physical dimensions, price and requirement of special training to use; cheap, small sized and easily carried domestic mobile invisible data matrix reader systems are required to be delivered to every inspector in the law enforcement units. In this paper, we first developed an apparatus attached to the smartphone including a red LED light and a high pass filter. Then, we promoted an algorithm to process captured images by smartphones and to decode all information stored in the invisible data matrix images. The proposed algorithm mainly involves four stages. In the first step, data matrix code is processed by Hough transform processing to find "L" shaped pattern. In the second step, borders of the data matrix are found by using the convex hull and corner detection methods. Afterwards, distortion of invisible data matrix corrected by geometric correction technique and the size of every module is fixed in rectangular shape. Finally, the invisible data matrix is scanned line by line in the horizontal axis to decode it. Based on the results obtained from the real test images of invisible data matrix captured with a smartphone, the proposed algorithm indicates high accuracy and low error rate.

Minimally invasive esthetic ridge preservation with growth-factor enhanced bone matrix.

Science.gov (United States)

Nevins, Marc L; Said, Sherif

2017-12-28

Extraction socket preservation procedures are critical to successful esthetic implant therapy. Conventional surgical approaches are technique sensitive and often result in alteration of the soft tissue architecture, which then requires additional corrective surgical procedures. This case series report presents the ability of flapless surgical techniques combined with a growth factor-enhanced bone matrix to provide esthetic ridge preservation at the time of extraction for compromised sockets. When considering esthetic dental implant therapy, preservation, or further enhancement of the available tissue support at the time of tooth extraction may provide an improved esthetic outcome with reduced postoperative sequelae and decreased treatment duration. Advances in minimally invasive surgical techniques combined with recombinant growth factor technology offer an alternative for bone reconstruction while maintaining the gingival architecture for enhanced esthetic outcome. The combination of freeze-dried bone allograft (FDBA) and rhPDGF-BB (platelet-derived growth factor-BB) provides a growth-factor enhanced matrix to induce bone and soft tissue healing. The use of a growth-factor enhanced matrix is an option for minimally invasive ridge preservation procedures for sites with advanced bone loss. Further studies including randomized clinical trials are needed to better understand the extent and limits of these procedures. The use of minimally invasive techniques with growth factors for esthetic ridge preservation reduces patient morbidity associated with more invasive approaches and increases the predictability for enhanced patient outcomes. By reducing the need for autogenous bone grafts the use of this technology is favorable for patient acceptance and ease of treatment process for esthetic dental implant therapy. © 2017 Wiley Periodicals, Inc.

NLO corrections to the photon impact factor: Combining real and virtual corrections

International Nuclear Information System (INIS)

Bartels, J.; Colferai, D.; Kyrieleis, A.; Gieseke, S.

2002-08-01

In this third part of our calculation of the QCD NLO corrections to the photon impact factor we combine our previous results for the real corrections with the singular pieces of the virtual corrections and present finite analytic expressions for the quark-antiquark-gluon intermediate state inside the photon impact factor. We begin with a list of the infrared singular pieces of the virtual correction, obtained in the first step of our program. We then list the complete results for the real corrections (longitudinal and transverse photon polarization). In the next step we defined, for the real corrections, the collinear and soft singular regions and calculate their contributions to the impact factor. We then subtract the contribution due to the central region. Finally, we combine the real corrections with the singular pieces of the virtual corrections and obtain our finite results. (orig.)

Generalised Batho correction factor

International Nuclear Information System (INIS)

Siddon, R.L.

1984-01-01

There are various approximate algorithms available to calculate the radiation dose in the presence of a heterogeneous medium. The Webb and Fox product over layers formulation of the generalised Batho correction factor requires determination of the number of layers and the layer densities for each ray path. It has been shown that the Webb and Fox expression is inefficient for the heterogeneous medium which is expressed as regions of inhomogeneity rather than layers. The inefficiency of the layer formulation is identified as the repeated problem of determining for each ray path which inhomogeneity region corresponds to a particular layer. It has been shown that the formulation of the Batho correction factor as a product over inhomogeneity regions avoids that topological problem entirely. The formulation in terms of a product over regions simplifies the computer code and reduces the time required to calculate the Batho correction factor for the general heterogeneous medium. (U.K.)

Development and application of a density dependent matrix ...

Science.gov (United States)

Ranging along the Atlantic coast from US Florida to the Maritime Provinces of Canada, the Atlantic killifish (Fundulus heteroclitus) is an important and well-studied model organism for understanding the effects of pollutants and other stressors in estuarine and marine ecosystems. Matrix population models are useful tools for ecological risk assessment because they integrate effects across the life cycle, provide a linkage between endpoints observed in the individual and ecological risk to the population as a whole, and project outcomes for many generations in the future. We developed a density dependent matrix population model for Atlantic killifish by modifying a model developed for fathead minnow (Pimephales promelas) that has proved to be extremely useful, e.g. to incorporate data from laboratory studies and project effects of endocrine disrupting chemicals. We developed a size-structured model (as opposed to one that is based upon developmental stages or age class structure) so that we could readily incorporate output from a Dynamic Energy Budget (DEB) model, currently under development. Due to a lack of sufficient data to accurately define killifish responses to density dependence, we tested a number of scenarios realistic for other fish species in order to demonstrate the outcome of including this ecologically important factor. We applied the model using published data for killifish exposed to dioxin-like compounds, and compared our results to those using

Coherent scattering and matrix correction in bone-lead measurements

International Nuclear Information System (INIS)

Todd, A.C.

2000-01-01

The technique of K-shell x-ray fluorescence of lead in bone has been used in many studies of the health effects of lead. This paper addresses one aspect of the technique, namely the coherent conversion factor (CCF) which converts between the matrix of the calibration standards and those of human bone. The CCF is conventionally considered a constant but is a function of scattering angle, energy and the elemental composition of the matrices. The aims of this study were to quantify the effect on the CCF of several assumptions which may not have been tested adequately and to compare the CCFs for plaster of Paris (the present matrix of calibration standards) and a synthetic apatite matrix. The CCF was calculated, using relativistic form factors, for published compositions of bone, both assumed and assessed compositions of plaster, and the synthetic apatite. The main findings of the study were, first, that impurities in plaster, lead in the plaster or bone matrices, coherent scatter from non-bone tissues and the individual subject's measurement geometry are all minor or negligible effects; and, second, that the synthetic apatite matrix is more representative of bone mineral than is plaster of Paris. (author)

Model Correction Factor Method

DEFF Research Database (Denmark)

Christensen, Claus; Randrup-Thomsen, Søren; Morsing Johannesen, Johannes

1997-01-01

The model correction factor method is proposed as an alternative to traditional polynomial based response surface techniques in structural reliability considering a computationally time consuming limit state procedure as a 'black box'. The class of polynomial functions is replaced by a limit...... of the model correction factor method, is that in simpler form not using gradient information on the original limit state function or only using this information once, a drastic reduction of the number of limit state evaluation is obtained together with good approximations on the reliability. Methods...

Assessment of radioactivity for 24 hours urine sample depending on correction factor by using creatinine

International Nuclear Information System (INIS)

Kharita, M. H.; Maghrabi, M.

2006-09-01

Assessment of intake and internal does requires knowing the amount of radioactivity in 24 hours urine sample, sometimes it is difficult to get 24 hour sample because this method is not comfortable and in most cases the workers refuse to collect this amount of urine. This work focuses on finding correction factor of 24 hour sample depending on knowing the amount of creatinine in the sample whatever the size of this sample. Then the 24 hours excretion of radionuclide is calculated assuming the average creatinine excretion rate is 1.7 g per 24 hours, based on the amount of activity and creatinine in the urine sample. Several urine sample were collected from occupationally exposed workers the amount and ratios of creatinine and activity in these samples were determined, then normalized to 24 excretion of radionuclide. The average chemical recovery was 77%. It should be emphasized that this method should only be used if a 24 hours sample was not possible to collect. (author)

Extraction of the CKM matrix element Vus from the hyperon semileptonic decays

International Nuclear Information System (INIS)

Sharma, N.; Dahiya, H.; Chatley, P.K.

2010-01-01

The chiral constituent quark model with configuration mixing (χCQM config ), which is successful in explaining the weak vector and axial-vector form factors for the strangeness-changing as well as strangeness-nonchanging hyperon semileptonic decays at Q 2 =0, has been extended to determine the CKM matrix element V us for the strangeness-changing decays. The implications of the effect of the SU(3) symmetry breaking, Q 2 -dependence and radiative corrections on the form factors and V us have also been investigated. It is found that the results with SU(3) symmetry breaking show considerable improvement over the SU(3) symmetric results when compared with the existing experimental data. The inclusion of the Q 2 -dependence and radiative corrections in form factors have only a small effect on the prediction of V us as is expected from the theory. (orig.)

A method for determining an effective porosity correction factor for thermal conductivity in fast reactor uranium-plutonium oxide fuel pellets

International Nuclear Information System (INIS)

Inoue, Masaki; Abe, Kazuyuki; Sato, Isamu

2000-01-01

A reliable method has been developed for determining an effective porosity correction factor for calculating a realistic thermal conductivity for fast reactor uranium-plutonium (mixed) oxide fuel pellets. By using image analysis of the ceramographs of transverse sections of mixed-oxide fuel pellets, the fuel morphology could be classified into two basic types. One is a 'two-phase' type that consists of small pores dispersed in the fuel matrix. The other is a 'three-phase' type that has large pores in addition to the small pores dispersed in the fuel matrix. The pore sizes are divided into two categories, large and small, at the 30 μm area equivalent diameter. These classifications lead to an equation for calculating an effective porosity correction factor by accounting for the small and large pore volume fractions and coefficients. This new analytical method for determining the effective porosity correction factor for calculating the realistic thermal conductivity of mixed-oxide fuel was also experimentally confirmed for high-, medium- and low-density fuel pellets

QUEUEING DISCIPLINES BASED ON PRIORITY MATRIX

Directory of Open Access Journals (Sweden)

Taufik I. Aliev

2014-11-01

Full Text Available The paper deals with queueing disciplines for demands of general type in queueing systems with multivendor load. A priority matrix is proposed to be used for the purpose of mathematical description of such disciplines, which represents the priority type (preemptive priority, not preemptive priority or no priority between any two demands classes. Having an intuitive and simple way of priority assignment, such description gives mathematical dependencies of system operation characteristics on its parameters. Requirements for priority matrix construction are formulated and the notion of canonical priority matrix is given. It is shown that not every matrix, constructed in accordance with such requirements, is correct. The notion of incorrect priority matrix is illustrated by an example, and it is shown that such matrixes do not ensure any unambiguousness and determinacy in design of algorithm, which realizes corresponding queueing discipline. Rules governing construction of correct matrixes are given for canonical priority matrixes. Residence time for demands of different classes in system, which is the sum of waiting time and service time, is considered as one of the most important characteristics. By introducing extra event method Laplace transforms for these characteristics are obtained, and mathematical dependencies are derived on their basis for calculation of two first moments for corresponding characteristics of demands queueing

Evaluation of ion chamber dependent correction factors for ionisation chamber dosimetry in proton beams using a Monte Carlo method

Energy Technology Data Exchange (ETDEWEB)

Palmans, H [Ghent Univ. (Belgium). Dept. of Biomedical Physics; Verhaegen, F

1995-12-01

In the last decade, several clinical proton beam therapy facilities have been developed. To satisfy the demand for uniformity in clinical (routine) proton beam dosimetry two dosimetry protocols (ECHED and AAPM) have been published. Both protocols neglect the influence of ion chamber dependent parameters on dose determination in proton beams because of the scatter properties of these beams, although the problem has not been studied thoroughly yet. A comparison between water calorimetry and ionisation chamber dosimetry showed a discrepancy of 2.6% between the former method and ionometry following the ECHED protocol. Possibly, a small part of this difference can be attributed to chamber dependent correction factors. Indications for this possibility are found in ionometry measurements. To allow the simulation of complex geometries with different media necessary for the study of those corrections, an existing proton Monte Carlo code (PTRAN, Berger) has been modified. The original code, that applies Mollire`s multiple scattering theory and Vavilov`s energy straggling theory, calculates depth dose profiles, energy distributions and radial distributions for pencil beams in water. Comparisons with measurements and calculations reported in the literature are done to test the program`s accuracy. Preliminary results of the influence of chamber design and chamber materials on dose to water determination are presented.

Evaluation of ion chamber dependent correction factors for ionisation chamber dosimetry in proton beams using a Monte Carlo method

International Nuclear Information System (INIS)

Palmans, H.; Verhaegen, F.

1995-01-01

In the last decade, several clinical proton beam therapy facilities have been developed. To satisfy the demand for uniformity in clinical (routine) proton beam dosimetry two dosimetry protocols (ECHED and AAPM) have been published. Both protocols neglect the influence of ion chamber dependent parameters on dose determination in proton beams because of the scatter properties of these beams, although the problem has not been studied thoroughly yet. A comparison between water calorimetry and ionisation chamber dosimetry showed a discrepancy of 2.6% between the former method and ionometry following the ECHED protocol. Possibly, a small part of this difference can be attributed to chamber dependent correction factors. Indications for this possibility are found in ionometry measurements. To allow the simulation of complex geometries with different media necessary for the study of those corrections, an existing proton Monte Carlo code (PTRAN, Berger) has been modified. The original code, that applies Mollire's multiple scattering theory and Vavilov's energy straggling theory, calculates depth dose profiles, energy distributions and radial distributions for pencil beams in water. Comparisons with measurements and calculations reported in the literature are done to test the program's accuracy. Preliminary results of the influence of chamber design and chamber materials on dose to water determination are presented

Low-Rank Matrix Factorization With Adaptive Graph Regularizer.

Science.gov (United States)

Lu, Gui-Fu; Wang, Yong; Zou, Jian

2016-05-01

In this paper, we present a novel low-rank matrix factorization algorithm with adaptive graph regularizer (LMFAGR). We extend the recently proposed low-rank matrix with manifold regularization (MMF) method with an adaptive regularizer. Different from MMF, which constructs an affinity graph in advance, LMFAGR can simultaneously seek graph weight matrix and low-dimensional representations of data. That is, graph construction and low-rank matrix factorization are incorporated into a unified framework, which results in an automatically updated graph rather than a predefined one. The experimental results on some data sets demonstrate that the proposed algorithm outperforms the state-of-the-art low-rank matrix factorization methods.

SU-E-T-644: Evaluation of Angular Dependence Correction for 2D Array Detector Using for Quality Assurance of Volumetric Modulated Arc Therapy

International Nuclear Information System (INIS)

Karthikeyan, N; Ganesh, K M; Vikraman, S; Shariff, MH

2014-01-01

Purpose: To evaluate the angular dependence correction for Matrix Evolution 2D array detector in quality assurance of volumetric modulated arc therapy(VMAT). Methods: Total ten patients comprising of different sites were planned for VMAT and taken for the study. Each plan was exposed on Matrix Evolution 2D array detector with Omnipro IMRT software based on the following three different methods using 6MV photon beams from Elekta Synergy linear accelerator. First method, VMAT plan was delivered on Matrix Evolution detector as it gantry mounted with dedicated holder with build-up of 2.3cm. Second, the VMAT plan was delivered with the static gantry angle on to the table mounted setup. Third, the VMAT plan was delivered with actual gantry angle on Matrix Evolution detector fixed in Multicube phantom with gantry angle sensor and angular dependence correction were applied to quantify the plan quality. For all these methods, the corresponding QA plans were generated in TPS and the dose verification was done for both point and 2D fluence analysis with pass criteria of 3% dose difference and 3mm distance to agreement. Results: The measured point dose variation for the first method was observed as 1.58±0.6% of mean and SD with TPS calculated. For second and third method, the mean and standard deviation(SD) was observed as 1.67±0.7% and 1.85±0.8% respectively. The 2D fluence analysis of measured and TPS calculated has the mean and SD of 97.9±1.1%, 97.88±1.2% and 97.55±1.3% for first, second and third methods respectively. The calculated two-tailed Pvalue for point dose and 2D fluence analysis shows the insignificance with values of 0.9316 and 0.9015 respectively, among the different methods of QA. Conclusion: The qualitative evaluation of angular dependence correction for Matrix Evolution 2D array detector shows its competency in accuracy of quality assurance measurement of composite dose distribution of volumetric modulated arc therapy

The temperature dependence of the static structure factor for liquid 4He below Tsub(lambda)

International Nuclear Information System (INIS)

Puoskari, M.; Kallio, A.; Pollari, P.

1984-01-01

The temperature dependence of the structure factor S(k,T) is studied based on an assumption that the anomalous behaviour of S(k,T) below Tsub(lambda) is due to thermally excited rotons and phonons. The calculation of S(k,T) is performed with the help of the HNC-equation from a model density matrix of Penrose which in turn is obtained from a quasiparticle Hamiltonian describing elementary excitations of liquid helium (both phonons and rotons). The results are in qualitative agreement with recent neutron and X-ray scattering experiments below Tsub(lambda). The theoretical temperature correction is used to deduce S(k,T=0) separately from the most recent X-ray and neutron scattering experiments. (Auth.)

Energy-dependency correction factors for the digital dosimeters using in NMD environment dose assessment

International Nuclear Information System (INIS)

Lai, Y.C.; Huang, Y. F.; Chen, Y.W.

2008-01-01

Full text: Short-term environment dose-rate assessments using real-time digital dosimeters within a Nuclear Medicine Department (NMD) are gaining more world-wide uses recently. In the past, conventional ion chamber-type survey-meters are used dominantly in environmental dose rates evaluation. Although it has suffered less gamma energy-dependency, but it is less sensitive in comparison with other digital dosimeters and more bulky in design that can hardly make it into a pocket size application. With modern electronic advancement and its shrinking in physical size, real-time personal dosimeter nowadays has gaining more popular to use a miniature G-M counter or a solid-state diode sensor, or even a NaI(Tl) scintillation device for ambient radiation monitoring. Radiation sensor operated in pulse-mode can never been used in doses or dose rates determination since each digital pulse has carried no energy information of the impinging gamma ray being interactive with, especially in the G-M counter or the diode sensor case. The raw count rates measured from a pulse-mode device are heavily dependent on the packaging of the sensor to make it less energy-sensitive. The doses or dose rates are then calculated by using a built-in conversion factor, based on a Cs-137 beam source calibration data conducted by various manufacturing vendors, to convert its raw counts into a so-called dose or dose-rate unit. In this study, we have focused our interests in the low energy response of the digital dosimeters from several brands currently for our in-house uses. Mainly, Tc-99m and I-131 in point sources and water phantoms detection configurations have been deployed to simulate our NMD outpatients for environment radiation monitoring purpose. The energy-dependent correction factors of the digital dosimeters will be evaluated by using calibrated Tc-99m or I-131 standard sources directly that has much lower gamma energy than the Cs-137 beam source of 661 keV. In the near future, we would

Scale dependence of the effective matrix diffusion coefficient: Evidence and preliminary interpretation

International Nuclear Information System (INIS)

Liu, Hui-Hai; Zhang, Yingqi; Molz, Fred J.

2006-01-01

The exchange of solute mass (through molecular diffusion) between fluid in fractures and fluid in the rock matrix is called matrix diffusion. Owing to the orders-of-magnitude slower flow velocity in the matrix compared to fractures, matrix diffusion can significantly retard solute transport in fractured rock, and therefore is an important process for a variety of problems, including remediation of subsurface contamination and geological disposal of nuclear waste. The effective matrix diffusion coefficient (molecular diffusion coefficient in free water multiplied by matrix tortuosity) is an important parameter for describing matrix diffusion, and in many cases largely determines overall solute transport behavior. While matrix diffusion coefficient values measured from small rock samples in the laboratory are generally used for modeling field-scale solute transport in fractured rock (Boving and Grathwohl, 2001), several research groups recently have independently found that effective matrix diffusion coefficients much larger than laboratory measurements are needed to match field-scale tracer-test data (Neretnieks, 2002; Becker and Shapiro, 2000; Shapiro, 2001; Liu et al., 2003, 2004a). In addition to the observed enhancement, Liu et al. (2004b), based on a relatively small number of field-test results, reported that the effective matrix diffusion coefficient might be scale dependent, and, like permeability and dispersivity, it seems to increases with test scale. This scale-dependence has important implications for large-scale solute transport in fractured rock. Although a number of mechanisms have been proposed to explain the enhancement of the effective matrix diffusion coefficient, the potential scale dependence and its mechanisms are not fully investigated at this stage. The major objective of this study is to again demonstrate (based on more data published in the literature than those used in Liu et al. [2004b]) the potential scale dependence of the effective

Scale Dependence of the Effective Matrix Diffusion Coefficient : Evidence and Preliminary Interpretation

International Nuclear Information System (INIS)

H.H. Liu; Y. Zhang

2006-01-01

The exchange of solute mass (through molecular diffusion) between fluid in fractures and fluid in the rock matrix is called matrix diffusion. Owing to the orders-of-magnitude slower flow velocity in the matrix compared to fractures, matrix diffusion can significantly retard solute transport in fractured rock, and therefore is an important process for a variety of problems, including remediation of subsurface contamination and geological disposal of nuclear waste. The effective matrix diffusion coefficient (molecular diffusion coefficient in free water multiplied by matrix tortuosity) is an important parameter for describing matrix diffusion, and in many cases largely determines overall solute transport behavior. While matrix diffusion coefficient values measured from small rock samples in the laboratory are generally used for modeling field-scale solute transport in fractured rock (Boving and Grathwohl, 2001), several research groups recently have independently found that effective matrix diffusion coefficients much larger than laboratory measurements are needed to match field-scale tracer-test data (Neretnieks, 2002; Becker and Shapiro, 2000; Shapiro, 2001; Liu et al., 2003,2004a). In addition to the observed enhancement, Liu et al. (2004b), based on a relatively small number of field-test results, reported that the effective matrix diffusion coefficient might be scale dependent, and, like permeability and dispersivity, it seems to increases with test scale. This scale-dependence has important implications for large-scale solute transport in fractured rock. Although a number of mechanisms have been proposed to explain the enhancement of the effective matrix diffusion coefficient, the potential scale dependence and its mechanisms are not fully investigated at this stage. The major objective of this study is to again demonstrate (based on more data published in the literature than those used in Liu et al. [2004b]) the potential scale dependence of the effective

Markov model of the loan portfolio dynamics considering influence of management and external economic factors

Science.gov (United States)

Bozhalkina, Yana; Timofeeva, Galina

2016-12-01

Mathematical model of loan portfolio in the form of a controlled Markov chain with discrete time is considered. It is assumed that coefficients of migration matrix depend on corrective actions and external factors. Corrective actions include process of receiving applications, interaction with existing solvent and insolvent clients. External factors are macroeconomic indicators, such as inflation and unemployment rates, exchange rates, consumer price indices, etc. Changes in corrective actions adjust the intensity of transitions in the migration matrix. The mathematical model for forecasting the credit portfolio structure taking into account a cumulative impact of internal and external changes is obtained.

Time-dependent phase error correction using digital waveform synthesis

Science.gov (United States)

Doerry, Armin W.; Buskirk, Stephen

2017-10-10

The various technologies presented herein relate to correcting a time-dependent phase error generated as part of the formation of a radar waveform. A waveform can be pre-distorted to facilitate correction of an error induced into the waveform by a downstream operation/component in a radar system. For example, amplifier power droop effect can engender a time-dependent phase error in a waveform as part of a radar signal generating operation. The error can be quantified and an according complimentary distortion can be applied to the waveform to facilitate negation of the error during the subsequent processing of the waveform. A time domain correction can be applied by a phase error correction look up table incorporated into a waveform phase generator.

Megavoltage photon beam attenuation by carbon fiber couch tops and its prediction using correction factors

International Nuclear Information System (INIS)

Hayashi, Naoki; Shibamoto, Yuta; Obata, Yasunori; Kimura, Takashi; Nakazawa, Hisato; Hagiwara, Masahiro; Hashizume, Chisa I.; Mori, Yoshimasa; Kobayashi, Tatsuya

2010-01-01

The purpose of this study was to evaluate the effect of megavoltage photon beam attenuation (PBA) by couch tops and to propose a method for correction of PBA. Four series of phantom measurements were carried out. First, PBA by the exact couch top (ECT, Varian) and Imaging Couch Top (ICT, BrainLAB) was evaluated using a water-equivalent phantom. Second, PBA by Type-S system (Med-Tec), ECT and ICT was compared with a spherical phantom. Third, percentage depth dose (PDD) after passing through ICT was measured to compare with control data of PDD. Forth, the gantry angle dependency of PBA by ICT was evaluated. Then, an equation for PBA correction was elaborated and correction factors for PBA at isocenter were obtained. Finally, this method was applied to a patient with hepatoma. PBA of perpendicular beams by ICT was 4.7% on average. With the increase in field size, the measured values became higher. PBA by ICT was greater than that by Type-S system and ECT. PBA increased significantly as the angle of incidence increased, ranging from 4.3% at 180 deg to 11.2% at 120 deg. Calculated doses obtained by the equation and correction factors agreed quite well with the measured doses between 120 deg and 180 deg of angles of incidence. Also in the patient, PBA by ICT was corrected quite well by the equation and correction factors. In conclusion, PBA and its gantry angle dependency by ICT were observed. This simple method using the equation and correction factors appeared useful to correct the isocenter dose when the PBA effect cannot be corrected by a treatment planning system. (author)

Time-dependent--S-matrix Hartree-Fock theory of complex reactions

International Nuclear Information System (INIS)

Griffin, J.J.; Lichtner, P.C.; Dworzecka, M.

1980-01-01

Some limitations of the conventional time-dependent Hartree-Fock method for describing complex reactions are noted, and one particular ubiquitous defect is discussed in detail: the post-breakup spurious cross channel correlations which arise whenever several asymptotic reaction channels must be simultaneously described by a single determinant. A reformulated time-dependent--S-matrix Hartree-Fock theory is proposed, which obviates this difficulty. Axiomatic requirements minimal to assure that the time-dependent--S-matrix Hartree-Fock theory represents an unambiguous and physically interpretable asymptotic reaction theory are utilized to prescribe conditions upon the definition of acceptable asymptotic channels. That definition, in turn, defines the physical range of the time-dependent--S-matrix Hartree-Fock theory to encompass the collisions of mathematically well-defined ''time-dependent Hartree-Fock droplets.'' The physical properties of these objects then circumscribe the content of the Hartree-Fock single determinantal description. If their periodic vibrations occur for continuous ranges of energy then the resulting ''classical'' time-dependent Hartree-Fock droplets are seen to be intrinsically dissipative, and the single determinantal description of their collisions reduces to a ''trajectory'' theory which can describe the masses and relative motions of the fragments but can provide no information about specific asymptotic excited states beyond their constants of motion, or the average properties of the limit, if it exists, of their equilibrization process. If, on the other hand, the periodic vibrations of the time-dependent Hartree-Fock droplets are discrete in energy, then the time-dependent--S-matrix Hartree-Fock theory can describe asymptotically the time-average properties of the whole spectrum of such periodic vibrations

Energy dependence corrections to MOSFET dosimetric sensitivity

International Nuclear Information System (INIS)

Cheung, T.; Yu, P.K.N.; Butson, M.J.; Illawarra Cancer Care Centre, Crown St, Wollongong

2009-01-01

Metal Oxide Semiconductor Field Effect Transistors (MOSFET's) are dosimeters which are now frequently utilized in radiotherapy treatment applications. An improved MOSFET, clinical semiconductor dosimetry system (CSDS) which utilizes improved packaging for the MOSFET device has been studied for energy dependence of sensitivity to x-ray radiation measurement. Energy dependence from 50 kVp to 10 MV x-rays has been studied and found to vary by up to a factor of 3.2 with 75 kVp producing the highest sensitivity response. The detectors average life span in high sensitivity mode is energy related and ranges from approximately 100 Gy for 75 kVp x-rays to approximately 300 Gy at 6MV x-ray energy. The MOSFET detector has also been studied for sensitivity variations with integrated dose history. It was found to become less sensitive to radiation with age and the magnitude of this effect is dependant on radiation energy with lower energies producing a larger sensitivity reduction with integrated dose. The reduction in sensitivity is however approximated reproducibly by a slightly non linear, second order polynomial function allowing corrections to be made to reading to account for this effect to provide more accurate dose assessments both in phantom and in-vivo.

Energy dependence corrections to MOSFET dosimetric sensitivity.

Science.gov (United States)

Cheung, T; Butson, M J; Yu, P K N

2009-03-01

Metal Oxide Semiconductor Field Effect Transistors (MOSFET's) are dosimeters which are now frequently utilized in radiotherapy treatment applications. An improved MOSFET, clinical semiconductor dosimetry system (CSDS) which utilizes improved packaging for the MOSFET device has been studied for energy dependence of sensitivity to x-ray radiation measurement. Energy dependence from 50 kVp to 10 MV x-rays has been studied and found to vary by up to a factor of 3.2 with 75 kVp producing the highest sensitivity response. The detectors average life span in high sensitivity mode is energy related and ranges from approximately 100 Gy for 75 kVp x-rays to approximately 300 Gy at 6 MV x-ray energy. The MOSFET detector has also been studied for sensitivity variations with integrated dose history. It was found to become less sensitive to radiation with age and the magnitude of this effect is dependant on radiation energy with lower energies producing a larger sensitivity reduction with integrated dose. The reduction in sensitivity is however approximated reproducibly by a slightly non linear, second order polynomial function allowing corrections to be made to readings to account for this effect to provide more accurate dose assessments both in phantom and in-vivo.

Correction factors for 13C-labelled substrate oxidation at whole-body and muscle level

DEFF Research Database (Denmark)

Van Hall, Gerrit

1999-01-01

acid cycle. Changes in metabolic rate induced, for example, by feeding, hormonal changes and physical activity, as well as infusion time, have been shown to affect both correction factors. The present paper explains the theoretical and physiological basis of these correction factors and makes...... for the proportion of labelled CO2 that is produced via oxidation but not excreted. Furthermore, depending on the substrate and position of the C label(s), there may also be a need to correct for labelled C from the metabolized substrate that does not appear as CO2, but rather becomes temporarily fixed in other...

Attenuation correction method for single photon emission CT

Energy Technology Data Exchange (ETDEWEB)

Morozumi, Tatsuru; Nakajima, Masato [Keio Univ., Yokohama (Japan). Faculty of Science and Technology; Ogawa, Koichi; Yuta, Shinichi

1983-10-01

A correction method (Modified Correction Matrix method) is proposed to implement iterative correction by exactly measuring attenuation constant distribution in a test body, calculating a correction factor for every picture element, then multiply the image by these factors. Computer simulation for the comparison of the results showed that the proposed method was specifically more effective to an application to the test body, in which the rate of attenuation constant change is large, than the conventional correction matrix method. Since the actual measurement data always contain quantum noise, the noise was taken into account in the simulation. However, the correction effect was large even under the noise. For verifying its clinical effectiveness, the experiment using an acrylic phantom was also carried out. As the result, the recovery of image quality in the parts with small attenuation constant was remarkable as compared with the conventional method.

Calculation of the Pitot tube correction factor for Newtonian and non-Newtonian fluids.

Science.gov (United States)

Etemad, S Gh; Thibault, J; Hashemabadi, S H

2003-10-01

This paper presents the numerical investigation performed to calculate the correction factor for Pitot tubes. The purely viscous non-Newtonian fluids with the power-law model constitutive equation were considered. It was shown that the power-law index, the Reynolds number, and the distance between the impact and static tubes have a major influence on the Pitot tube correction factor. The problem was solved for a wide range of these parameters. It was shown that employing Bernoulli's equation could lead to large errors, which depend on the magnitude of the kinetic energy and energy friction loss terms. A neural network model was used to correlate the correction factor of a Pitot tube as a function of these three parameters. This correlation is valid for most Newtonian, pseudoplastic, and dilatant fluids at low Reynolds number.

A general X-ray fluorescence spectrometric technique based on simple corrections for matrix effects

International Nuclear Information System (INIS)

Kruidhof, H.

1978-01-01

The method reported, which is relatively simple and generally applicable for most materials, involves a combination of borax fusion with matrix effect corrections. The latter are done with algorithms, which are derived from the intensity formulae, together with empirical coefficients. (Auth.)

Nonnegative Matrix Factorizations Performing Object Detection and Localization

Directory of Open Access Journals (Sweden)

G. Casalino

2012-01-01

Full Text Available We study the problem of detecting and localizing objects in still, gray-scale images making use of the part-based representation provided by nonnegative matrix factorizations. Nonnegative matrix factorization represents an emerging example of subspace methods, which is able to extract interpretable parts from a set of template image objects and then to additively use them for describing individual objects. In this paper, we present a prototype system based on some nonnegative factorization algorithms, which differ in the additional properties added to the nonnegative representation of data, in order to investigate if any additional constraint produces better results in general object detection via nonnegative matrix factorizations.

Syringe calibration factors and volume correction factors for the NPL secondary standard radionuclide calibrator

CERN Document Server

Tyler, D K

2002-01-01

The activity assay of a radiopharmaceutical administration to a patient is normally achieved via the use of a radionuclide calibrator. Because of the different geometries and elemental compositions between plastic syringes and glass vials, the calibration factors for syringes may well be significantly different from those for the glass containers. The magnitude of these differences depends on the energies of the emitted photons. For some radionuclides variations have been observed of 70 %, it is therefore important to recalibrate for syringes or use syringe calibration factors. Calibration factors and volume correction factors have been derived for the NPL secondary standard radionuclide calibrator, for a variety of commonly used syringes and needles, for the most commonly used medical radionuclide.

Correction of SiPM temperature dependencies

International Nuclear Information System (INIS)

Kaplan, A.

2009-01-01

The performance of a high granular analogue hadronic calorimeter (AHCAL) using scintillator tiles with built-in Silicon Photomultiplier (SiPM) readout is reported. A muon beam is used for the minimum ionizing particle (MIP) based calibration of the single cells. The calibration chain including corrections for the non-linearity of the SiPM is presented. The voltage and temperature dependencies of the SiPM signal have been investigated using the versatile LED system of the AHCAL. Monitoring and correction methods are discussed. Measurements from the operation 2006 and 2007 at the CERN SPS test beam and data provided by the Institute for Theoretical and Experimental Physics (ITEP) in Moscow are compared.

Source distribution dependent scatter correction for PVI

International Nuclear Information System (INIS)

Barney, J.S.; Harrop, R.; Dykstra, C.J.

1993-01-01

Source distribution dependent scatter correction methods which incorporate different amounts of information about the source position and material distribution have been developed and tested. The techniques use image to projection integral transformation incorporating varying degrees of information on the distribution of scattering material, or convolution subtraction methods, with some information about the scattering material included in one of the convolution methods. To test the techniques, the authors apply them to data generated by Monte Carlo simulations which use geometric shapes or a voxelized density map to model the scattering material. Source position and material distribution have been found to have some effect on scatter correction. An image to projection method which incorporates a density map produces accurate scatter correction but is computationally expensive. Simpler methods, both image to projection and convolution, can also provide effective scatter correction

Instrumental dead-time and its relationship with matrix corrections in X-ray fluorescence analysis

International Nuclear Information System (INIS)

Thomas, I.L.; Haukka, M.T.; Anderson, D.H.

1979-01-01

The relationship between instrumental dead-time and the self-absorption coefficients, αsub(ii) in x.r.f. matrix correction by means of influence coefficients, is not generally recognized but has important analytical consequences. Systematic errors of the order of 1% (relative) for any analyte result from experimental uncertainties in instrumental dead-time. Such errors are applied unevenly across a given range of concentration because the error depends on the calibration standards and on the instrumental conditions used. Refinement of the instrumental dead-time value and other calibration parameters to conform with influence coefficients determined elsewhere assumes exact knowledge of dead-time of the instrument used originally, and quite similar excitation conditions and spectrometer geometry for the two instruments. Though these qualifications may not be met, adjustment of any of the parameters (dead-time, reference concentration, background concentration, self-absorption and other influence coefficients) can be easily achieved. (Auth.)

Graph Transformation and Designing Parallel Sparse Matrix Algorithms beyond Data Dependence Analysis

Directory of Open Access Journals (Sweden)

H.X. Lin

2004-01-01

Full Text Available Algorithms are often parallelized based on data dependence analysis manually or by means of parallel compilers. Some vector/matrix computations such as the matrix-vector products with simple data dependence structures (data parallelism can be easily parallelized. For problems with more complicated data dependence structures, parallelization is less straightforward. The data dependence graph is a powerful means for designing and analyzing parallel algorithms. However, for sparse matrix computations, parallelization based on solely exploiting the existing parallelism in an algorithm does not always give satisfactory results. For example, the conventional Gaussian elimination algorithm for the solution of a tri-diagonal system is inherently sequential, so algorithms specially for parallel computation has to be designed. After briefly reviewing different parallelization approaches, a powerful graph formalism for designing parallel algorithms is introduced. This formalism will be discussed using a tri-diagonal system as an example. Its application to general matrix computations is also discussed. Its power in designing parallel algorithms beyond the ability of data dependence analysis is shown by means of a new algorithm called ACER (Alternating Cyclic Elimination and Reduction algorithm.

High performance matrix inversion based on LU factorization for multicore architectures

KAUST Repository

Dongarra, Jack

2011-01-01

The goal of this paper is to present an efficient implementation of an explicit matrix inversion of general square matrices on multicore computer architecture. The inversion procedure is split into four steps: 1) computing the LU factorization, 2) inverting the upper triangular U factor, 3) solving a linear system, whose solution yields inverse of the original matrix and 4) applying backward column pivoting on the inverted matrix. Using a tile data layout, which represents the matrix in the system memory with an optimized cache-aware format, the computation of the four steps is decomposed into computational tasks. A directed acyclic graph is generated on the fly which represents the program data flow. Its nodes represent tasks and edges the data dependencies between them. Previous implementations of matrix inversions, available in the state-of-the-art numerical libraries, are suffer from unnecessary synchronization points, which are non-existent in our implementation in order to fully exploit the parallelism of the underlying hardware. Our algorithmic approach allows to remove these bottlenecks and to execute the tasks with loose synchronization. A runtime environment system called QUARK is necessary to dynamically schedule our numerical kernels on the available processing units. The reported results from our LU-based matrix inversion implementation significantly outperform the state-of-the-art numerical libraries such as LAPACK (5x), MKL (5x) and ScaLAPACK (2.5x) on a contemporary AMD platform with four sockets and the total of 48 cores for a matrix of size 24000. A power consumption analysis shows that our high performance implementation is also energy efficient and substantially consumes less power than its competitors. © 2011 ACM.

HIV-1 matrix dependent membrane targeting is regulated by Gag mRNA trafficking.

Directory of Open Access Journals (Sweden)

Jing Jin

Full Text Available Retroviral Gag polyproteins are necessary and sufficient for virus budding. Productive HIV-1 Gag assembly takes place at the plasma membrane. However, little is known about the mechanisms by which thousands of Gag molecules are targeted to the plasma membrane. Using a bimolecular fluorescence complementation (BiFC assay, we recently reported that the cellular sites and efficiency of HIV-1 Gag assembly depend on the precise pathway of Gag mRNA export from the nucleus, known to be mediated by Rev. Here we describe an assembly deficiency in human cells for HIV Gag whose expression depends on hepatitis B virus (HBV post-transcriptional regulatory element (PRE mediated-mRNA nuclear export. PRE-dependent HIV Gag expressed well in human cells, but assembled with slower kinetics, accumulated intracellularly, and failed to associate with a lipid raft compartment where the wild-type Rev-dependent HIV-1 Gag efficiently assembles. Surprisingly, assembly and budding of PRE-dependent HIV Gag in human cells could be rescued in trans by co-expression of Rev-dependent Gag that provides correct membrane targeting signals, or in cis by replacing HIV matrix (MA with other membrane targeting domains. Taken together, our results demonstrate deficient membrane targeting of PRE-dependent HIV-1 Gag and suggest that HIV MA function is regulated by the trafficking pathway of the encoding mRNA.

Sparse-matrix factorizations for fast symmetric Fourier transforms

International Nuclear Information System (INIS)

Sequel, J.

1987-01-01

This work proposes new fast algorithms computing the discrete Fourier transform of certain families of symmetric sequences. Sequences commonly found in problems of structure determination by x-ray crystallography and in numerical solutions of boundary-value problems in partial differential equations are dealt with. In the algorithms presented, the redundancies in the input and output data, due to the presence of symmetries in the input data sequence, were eliminated. Using ring-theoretical methods a matrix representation is obtained for the remaining calculations; which factors as the product of a complex block-diagonal matrix times as integral matrix. A basic two-step algorithm scheme arises from this factorization with a first step consisting of pre-additions and a second step containing the calculations involved in computing with the blocks in the block-diagonal factor. These blocks are structured as block-Hankel matrices, and two sparse-matrix factoring formulas are developed in order to diminish their arithmetic complexity

Stiffness-dependent cellular internalization of matrix-bound BMP-2 and its relation to Smad and non-Smad signaling.

Science.gov (United States)

Gilde, Flora; Fourel, Laure; Guillot, Raphael; Pignot-Paintrand, Isabelle; Okada, Takaharu; Fitzpatrick, Vincent; Boudou, Thomas; Albiges-Rizo, Corinne; Picart, Catherine

2016-12-01

Surface coatings delivering BMP are a promising approach to render biomaterials osteoinductive. In contrast to soluble BMPs which can interact with their receptors at the dorsal side of the cell, BMPs presented as an insoluble cue physically bound to a biomimetic matrix, called here matrix-bound (bBMP-2), are presented to cells by their ventral side. To date, BMP-2 internalization and signaling studies in cell biology have always been performed by adding soluble (sBMP-2) to cells adhered on cell culture plates or glass slides, which will be considered here as a "reference" condition. However, whether and how matrix-bound BMP-2 can be internalized by cells and its relation to canonical (SMAD) and non-canonical signaling (ALP) remain open questions. In this study, we investigated the uptake and processing of BMP-2 by C2C12 myoblasts. This BMP-2 was presented either embedded in polyelectrolyte multilayer films (matrix-bound presentation) or as soluble form. Using fluorescently labeled BMP-2, we showed that the amount of matrix-bound BMP-2 internalized is dependent on the level of crosslinking of the polyelectrolyte films. Cav-1-mediated internalization is related to both SMAD and ALP signaling, while clathrin-mediated is only related to ALP signaling. BMP-2 internalization was independent of the presentation mode (sBMP-2 versus bBMP-2) for low crosslinked films (soft, EDC10) in striking contrast with high crosslinked (stiff, EDC70) films where internalization was much lower and slower for bBMP-2. As anticipated, internalization of sBMP-2 barely depended on the underlying matrix. Taken together, these results indicate that BMP-2 internalization can be tuned by the underlying matrix and activates downstream BMP-2 signaling, which is key for the effective formation of bone tissue. The presentation of growth factors from material surfaces currently presents significant challenges in academic research, clinics and industry. Being able to deliver efficiently these growth

Construction of the Dependence Matrix Based on the TRIZ Contradiction Matrix in OOD

Science.gov (United States)

Ma, Jianhong; Zhang, Quan; Wang, Yanling; Luo, Tao

In the Object-Oriented software design (OOD), design of the class and object, definition of the classes’ interface and inheritance levels and determination of dependent relations have a serious impact on the reusability and flexibility of the system. According to the concrete problems of design, how to select the right solution from the hundreds of the design schemas which has become the focus of attention of designers. After analyzing lots of software design schemas in practice and Object-Oriented design patterns, this paper constructs the dependence matrix of Object-Oriented software design filed, referring to contradiction matrix of TRIZ (Theory of Inventive Problem Solving) proposed by the former Soviet Union innovation master Altshuller. As the practice indicates, it provides a intuitive, common and standardized method for designers to choose the right design schema. Make research and communication more effectively, and also improve the software development efficiency and software quality.

Convergence Improvement of Response Matrix Method with Large Discontinuity Factors

International Nuclear Information System (INIS)

Yamamoto, Akio

2003-01-01

In the response matrix method, a numerical divergence problem has been reported when extremely small or large discontinuity factors are utilized in the calculations. In this paper, an alternative response matrix formulation to solve the divergence problem is discussed, and properties of iteration matrixes are investigated through eigenvalue analyses. In the conventional response matrix formulation, partial currents between adjacent nodes are assumed to be discontinuous, and outgoing partial currents are converted into incoming partial currents by the discontinuity factor matrix. Namely, the partial currents of the homogeneous system (i.e., homogeneous partial currents) are treated in the conventional response matrix formulation. In this approach, the spectral radius of an iteration matrix for the partial currents may exceed unity when an extremely small or large discontinuity factor is used. Contrary to this, an alternative response matrix formulation using heterogeneous partial currents is discussed in this paper. In the latter approach, partial currents are assumed to be continuous between adjacent nodes, and discontinuity factors are directly considered in the coefficients of a response matrix. From the eigenvalue analysis of the iteration matrix for the one-group, one-dimensional problem, the spectral radius for the heterogeneous partial current formulation does not exceed unity even if an extremely small or large discontinuity factor is used in the calculation; numerical stability of the alternative formulation is superior to the conventional one. The numerical stability of the heterogeneous partial current formulation is also confirmed by the two-dimensional light water reactor core analysis. Since the heterogeneous partial current formulation does not require any approximation, the converged solution exactly reproduces the reference solution when the discontinuity factors are directly derived from the reference calculation

Chronic mild stress influences nerve growth factor through a matrix metalloproteinase-dependent mechanism.

Science.gov (United States)

Kucharczyk, Mateusz; Kurek, Anna; Detka, Jan; Slusarczyk, Joanna; Papp, Mariusz; Tota, Katarzyna; Basta-Kaim, Agnieszka; Kubera, Marta; Lason, Wladyslaw; Budziszewska, Bogusława

2016-04-01

Stress is generally a beneficial experience that motivates an organism to action to overcome the stressful challenge. In particular situations, when stress becomes chronic might be harmful and devastating. The hypothalamus is a critical coordinator of stress and the metabolic response; therefore, disruptions in this structure may be a significant cause of the hormonal and metabolic disturbances observed in depression. Chronic stress induces adverse changes in the morphology of neural cells that are often associated with a deficiency of neurotrophic factors (NTFs); additionally, many studies indicate that insufficient NTF synthesis may participate in the pathogenesis of depression. The aim of the present study was to determine the expression of the nerve growth factor (NGF) in the hypothalamus of male rats subjected to chronic mild stress (CMS) or to prenatal stress (PS) and to PS in combination with an acute stress event (AS). It has been found that chronic mild stress, but not prenatal stress, acute stress or a combination of PS with AS, decreased the concentration of the mature form of NGF (m-NGF) in the rat hypothalamus. A discrepancy between an increase in the Ngf mRNA and a decrease in the m-NGF levels suggested that chronic mild stress inhibited NGF maturation or enhanced the degradation of this factor. We have shown that NGF degradation in the hypothalamus of rats subjected to chronic mild stress is matrix metalloproteinase-dependent and related to an increase in the active forms of some metalloproteinases (MMP), including MMP2, MMP3, MMP9 and MMP13, while the NGF maturation process does not seem to be changed. We suggested that activated MMP2 and MMP9 potently cleave the mature but not the pro- form of NGF into biologically inactive products, which is the reason for m-NGF decomposition. In turn, the enhanced expression of Ngf in the hypothalamus of these rats is an attempt to overcome the reduced levels of m-NGF. Additionally, the decreased level of m

Incremental Nonnegative Matrix Factorization for Face Recognition

Directory of Open Access Journals (Sweden)

Wen-Sheng Chen

2008-01-01

Full Text Available Nonnegative matrix factorization (NMF is a promising approach for local feature extraction in face recognition tasks. However, there are two major drawbacks in almost all existing NMF-based methods. One shortcoming is that the computational cost is expensive for large matrix decomposition. The other is that it must conduct repetitive learning, when the training samples or classes are updated. To overcome these two limitations, this paper proposes a novel incremental nonnegative matrix factorization (INMF for face representation and recognition. The proposed INMF approach is based on a novel constraint criterion and our previous block strategy. It thus has some good properties, such as low computational complexity, sparse coefficient matrix. Also, the coefficient column vectors between different classes are orthogonal. In particular, it can be applied to incremental learning. Two face databases, namely FERET and CMU PIE face databases, are selected for evaluation. Compared with PCA and some state-of-the-art NMF-based methods, our INMF approach gives the best performance.

Matrix effect correction with internal flux monitor in radiation waste characterization with the Differential Die-away Technique

International Nuclear Information System (INIS)

Antoni, Rodolphe; Passard, Christian; Loridon, Joel; Perot, Bertrand; Batifol, Marc; Tarnec, Stephane-le; Guillaumin, Francois; Grassi, Gabriele; Strock, Pierre

2013-06-01

Radioactive waste drums filled with compacted metallic residues (spent fuel hulls and nozzles) produced at AREVA La Hague reprocessing plant are measured by neutron interrogation with the Differential Die-away measurement Technique (DDT). The purpose is to assay fissile material quantities present in radioactive waste packages. In the future, old hulls and nozzles containing Ion-Exchange Resin (IER) will be measured. IERs provide moderating properties to the matrix, not encountered during the current measurement. In this context, the Nuclear Measurement Laboratory (NML) of the CEA Cadarache has been asked by AREVA NC to explore the possibility of implementing a matrix effect correction method, based on internal monitor ( 3 He proportional counter) signal correlated to the matrix effect. In order to validate this method, a benchmark was performed with PROMETHEE 6 R and D measurement cell at the NML, with a similar cavity configuration to that of the industrial station. An experience design on two main factors regarding the matrix effect (absorbing and moderating ratios) has been studied. Considering the variation range of both factors for old waste measurement, 5 test matrices have been defined. They have been measured in PROMETHEE 6 and simulated using the particle transport code MCNP. Tests have been carried out experimentally using 235 U platelets. Results show that the experimental internal monitor is sensitive to the matrix but not to the fissile material presence and location. In addition, differences between experiment and model are satisfactory (<10%), in terms of prompt calibration coefficient (useful signal of fissile materials) and internal monitor signal, considering the complexity of the measurement method and numerical model, and the large range of moderator and absorption ratios. The relationship between the prompt calibration coefficient and the internal monitor signal observed in PROMETHEE 6, both for experience and model, can be fitted with a

Matrix effect correction with internal flux monitor in radiation waste characterization with the differential die-away technique

International Nuclear Information System (INIS)

Antoni, R.; Passard, C.; Loridon, J.; Perot, B.; Batifol, M.; Tarnec, S. le; Guillaumin, F.; Grassi, G.; Strock, P.

2014-01-01

Radioactive waste drums filled with compacted metallic residues (spent fuel hulls and nozzles) produced at AREVA La Hague reprocessing plant are measured by neutron interrogation with the Differential Die-away measurement Technique (DDT). The purpose is to assay fissile material quantities present in radioactive waste packages. In the future, old hulls and nozzles containing Ion-Exchange Resin (IER) will be measured. IERs provide moderating properties to the matrix, not encountered during the current measurement. In this context, the Nuclear Measurement Laboratory (NML) of the CEA Cadarache has been asked by AREVA NC to explore the possibility of implementing a matrix effect correction method, based on internal monitor ( 3 He proportional counter) signal correlated to the matrix effect. In order to validate this method, a benchmark was performed with PROMETHEE 6 R and D measurement cell at the NML, with a similar cavity configuration to that of the industrial station. An experimental design on two main factors regarding the matrix effect (absorbing and moderating ratios) has been studied. Considering the variation range of both factors for old waste measurement, 5 test matrices have been defined. They have been measured in PROMETHEE 6 and simulated using the particle transport code MCNP. Tests have been carried out experimentally using platelets. Results show that the experimental internal monitor is sensitive to the matrix but not to the fissile material presence and location. In addition, differences between experiment and model are satisfactory (≤10%), in terms of prompt calibration coefficient (useful signal of fissile materials) and internal monitor signal, considering the complexity of the measurement method and numerical model, and the large range of moderator and absorption ratios. The relationship between the prompt calibration coefficient and the internal monitor signal observed in PROMETHEE 6, both for experience and model, can be fitted with a similar

Massive Asynchronous Parallelization of Sparse Matrix Factorizations

Energy Technology Data Exchange (ETDEWEB)

Chow, Edmond [Georgia Inst. of Technology, Atlanta, GA (United States)

2018-01-08

Solving sparse problems is at the core of many DOE computational science applications. We focus on the challenge of developing sparse algorithms that can fully exploit the parallelism in extreme-scale computing systems, in particular systems with massive numbers of cores per node. Our approach is to express a sparse matrix factorization as a large number of bilinear constraint equations, and then solving these equations via an asynchronous iterative method. The unknowns in these equations are the matrix entries of the factorization that is desired.

Monte Carlo study of MOSFET dosimeter dose correction factors considering energy spectrum of radiation field in a steam generator channel head

Energy Technology Data Exchange (ETDEWEB)

Cho, Sung Koo; Choi, Sang Hyoun; Kim, Chan Hyeong [Hanyang Univ., Seoul (Korea, Republic of)

2006-12-15

In Korea, a real-time effective dose measurement system is in development. The system uses 32 high-sensitivity MOSFET dosimeters to measure radiation doses at various organ locations in an anthropomorphic physical phantom. The MOSFET dosimeters are, however, mainly made of silicon and shows some degree of energy and angular dependence especially for low energy photons. This study determines the correction factors to correct for these dependences of the MOSFET dosimeters for accurate measurement of radiation doses at organ locations in the phantom. For this, first, the dose correction factors of MOSFET dosimeters were determined for the energy spectrum in the steam generator channel of the Kori Nuclear Power Plant Unit no.1 by Monte Carlo simulations. Then, the results were compared with the dose correction factors from 0.662 MeV and 1.25 MeV mono-energetic photons. The difference of the dose correction factors were found very negligible ({<=}1.5%), which in general shows that the dose corrections factors determined from 0.662 MeV and 1.25 MeV can be in a steam general channel head of a nuclear power plant. The measured effective dose was generally found to decrease by {approx}7% when we apply the dose correction factors.

49 CFR 325.73 - Microphone distance correction factors. 1

Science.gov (United States)

2010-10-01

... 49 Transportation 5 2010-10-01 2010-10-01 false Microphone distance correction factors. 1 325.73 Section 325.73 Transportation Other Regulations Relating to Transportation (Continued) FEDERAL MOTOR... MOTOR CARRIER NOISE EMISSION STANDARDS Correction Factors § 325.73 Microphone distance correction...

Correcting the effects of the matrix using capture gamma-ray spectrometry: Application to measurement by Active Neutron Interrogation

International Nuclear Information System (INIS)

Baudry, G.

2003-11-01

In the field of the measurement of low masses of fissile material ( 235 U, 239 Pu, 241 Pu) in radioactive waste drums, the Active Neutron Interrogation is a non-destructive method achieving good results. It does however remain reliant upon uncertainties related to the matrix effects on interrogation and fission neutrons. The aim of this thesis is to develop a correction method able to take into account these matrix effects by quantifying the amount of absorbent materials (chlorine and hydrogen) in a 118- liter homogeneous matrix. The main idea is to use the gamma-ray spectrometry of gamma emitted by neutron captures to identify and quantify the composition of the matrix. An indicator from its chlorine content is then deduced in order to choose the calibration coefficient which best represents the real composition of the matrix. This document firstly presents the needs of control and characterization of radioactive objects, and the means used in the field of nuclear measurement. Emphases is put in particular on the Active Neutron Interrogation method. The matrices of interest are those made of light technological waste (density ≤ 0,4 g/cm 3 ) containing hydrogenated and chlorinated materials. The advantages of gamma-rays emitted by neutron captures for the determination of a chlorine content indicator of the matrices and the principles of the correction method are then explained. Measurements have been firstly realized with an existing Neutron Interrogation device (PROMETHEE 6). Such measurements have proven its inadequacy: no signal from the matrix hydrogen was detected, due to an intense signal from the polyethylene contained in some cell elements. Moreover, the matrix chlorine content appeared difficult to be measured. A new and specific device, named REGAIN and dedicated to active gamma-rays spectrometry, was defined with the Monte-Carlo N-Particle (MCNP) code. The experiments conducted with this new device made it possible to detect the hydrogen from the

Z4-symmetric factorized S-matrix in two space-time dimensions

International Nuclear Information System (INIS)

Zamolodchikov, A.B.

1979-01-01

The factorized S-matrix with internal symmetry Z 4 is constructed in two space-time dimensions. The two-particle amplitudes are obtained by means of solving the factorization, unitarity and analyticity equations. The solution of factorization equations can be expressed in terms of elliptic functions. The S-matrix cotains the resonance poles naturally. The simple formal relation between the general factorized S-matrices and the Baxter-type lattice transfer matrices is found. In the sense of this relation the Z 4 -symmetric S-matrix corresponds to the Baxter transfer matrix itself. (orig.)

Shifted Non-negative Matrix Factorization

DEFF Research Database (Denmark)

Mørup, Morten; Madsen, Kristoffer Hougaard; Hansen, Lars Kai

2007-01-01

Non-negative matrix factorization (NMF) has become a widely used blind source separation technique due to its part based representation and ease of interpretability. We currently extend the NMF model to allow for delays between sources and sensors. This is a natural extension for spectrometry data...

Matrix Metalloproteinases Contribute to Neuronal Dysfunction in Animal Models of Drug Dependence, Alzheimer's Disease, and Epilepsy

Directory of Open Access Journals (Sweden)

Hiroyuki Mizoguchi

2011-01-01

Full Text Available Matrix metalloproteinases (MMPs and tissue inhibitors of metalloproteinases (TIMPs remodel the pericellular environment by regulating the cleavage of extracellular matrix proteins, cell surface components, neurotransmitter receptors, and growth factors that mediate cell adhesion, synaptogenesis, synaptic plasticity, and long-term potentiation. Interestingly, increased MMP activity and dysregulation of the balance between MMPs and TIMPs have also been implicated in various pathologic conditions. In this paper, we discuss various animal models that suggest that the activation of the gelatinases MMP-2 and MMP-9 is involved in pathogenesis of drug dependence, Alzheimer's disease, and epilepsy.

Multi-view clustering via multi-manifold regularized non-negative matrix factorization.

Science.gov (United States)

Zong, Linlin; Zhang, Xianchao; Zhao, Long; Yu, Hong; Zhao, Qianli

2017-04-01

Non-negative matrix factorization based multi-view clustering algorithms have shown their competitiveness among different multi-view clustering algorithms. However, non-negative matrix factorization fails to preserve the locally geometrical structure of the data space. In this paper, we propose a multi-manifold regularized non-negative matrix factorization framework (MMNMF) which can preserve the locally geometrical structure of the manifolds for multi-view clustering. MMNMF incorporates consensus manifold and consensus coefficient matrix with multi-manifold regularization to preserve the locally geometrical structure of the multi-view data space. We use two methods to construct the consensus manifold and two methods to find the consensus coefficient matrix, which leads to four instances of the framework. Experimental results show that the proposed algorithms outperform existing non-negative matrix factorization based algorithms for multi-view clustering. Copyright © 2017 Elsevier Ltd. All rights reserved.

The time-dependent density matrix renormalisation group method

Science.gov (United States)

Ma, Haibo; Luo, Zhen; Yao, Yao

2018-04-01

Substantial progress of the time-dependent density matrix renormalisation group (t-DMRG) method in the recent 15 years is reviewed in this paper. By integrating the time evolution with the sweep procedures in density matrix renormalisation group (DMRG), t-DMRG provides an efficient tool for real-time simulations of the quantum dynamics for one-dimensional (1D) or quasi-1D strongly correlated systems with a large number of degrees of freedom. In the illustrative applications, the t-DMRG approach is applied to investigate the nonadiabatic processes in realistic chemical systems, including exciton dissociation and triplet fission in polymers and molecular aggregates as well as internal conversion in pyrazine molecule.

Correction factor for the experimental prompt neutron decay constant

International Nuclear Information System (INIS)

Talamo, Alberto; Gohar, Y.; Sadovich, S.; Kiyavitskaya, H.; Bournos, V.; Fokov, Y.; Routkovskaya, C.

2013-01-01

Highlights: • Definition of a spatial correction factor for the experimental prompt neutron decay constant. • Introduction of a MCNP6 calculation methodology to simulate Rossi-alpha distribution for pulsed neutron sources. • Comparison of MCNP6 results with experimental data for count rate, Rossi-alpha, and Feynman-alpha distributions. • Improvement of the comparison between numerical and experimental results by taking into account the dead-time effect. - Abstract: This study introduces a new correction factor to obtain the experimental effective multiplication factor of subcritical assemblies by the point kinetics formulation. The correction factor is defined as the ratio between the MCNP6 prompt neutron decay constant obtained in criticality mode and the one obtained in source mode. The correction factor mainly takes into account the longer neutron lifetime in the reflector region and the effects of the external neutron source. For the YALINA Thermal facility, the comparison between the experimental and computational effective multiplication factors noticeably improves after the application of the correction factor. The accuracy of the MCNP6 computational model of the YALINA Thermal subcritical assembly has been verified by reproducing the neutron count rate, Rossi-α, and Feynman-α distributions obtained from the experimental data

Stationary solution of a time dependent density matrix formalism

International Nuclear Information System (INIS)

Tohyama, Mitsuru

1994-01-01

A stationary solution of a time-dependent density-matrix formalism, which is an extension of the time-dependent Hartree-Fock theory to include the effects of two-body correlations, is obtained for the Lipkin model hamiltonian, using an adiabatic treatment of the two-body interaction. It is found that the obtained result is a reasonable approximation for the exact solution of the model. (author)

The S-Matrix coupling dependence for a, d and e affine Toda field theory

International Nuclear Information System (INIS)

Braden, H.W.; Sasaki, R.

1990-09-01

Affine Toda field theories are solvable 1+1 dimensional quantum field theories closely related to integrable deformations of conformal field theory. The S-Matrix elements for an affine Toda field theory are known to depend on the coupling constant β through one universal function B(β) which cannot be determined by unitarity, crossing and the bootstrap. From the requirement of nonexistence of extra poles in the physical region its form is conjectured to be B(β) = (2π) -1 ·β 2 /((1+β 2 )/4π). We show that the above conjecture is correct up to one loop order (i.e., β 4 ) of perturbation for simply laced, i.e., a, d and e affine Toda field theories using a general argument which exhibits much of the richness of these theories. (author)

Matrix-dependent multigrid-homogenization for diffusion problems

Energy Technology Data Exchange (ETDEWEB)

Knapek, S. [Institut fuer Informatik tu Muenchen (Germany)

1996-12-31

We present a method to approximately determine the effective diffusion coefficient on the coarse scale level of problems with strongly varying or discontinuous diffusion coefficients. It is based on techniques used also in multigrid, like Dendy`s matrix-dependent prolongations and the construction of coarse grid operators by means of the Galerkin approximation. In numerical experiments, we compare our multigrid-homogenization method with homogenization, renormalization and averaging approaches.

Time dependent density matrix theory and effective interaction

Energy Technology Data Exchange (ETDEWEB)

Tohyama, Mitsuru [Kyorin Univ., Mitaka, Tokyo (Japan). School of Medicine

1998-07-01

A correlated ground state of {sup 16}O and an E2 giant resonance built on it are calculated using an extended version of the time-dependent Hartree-Fock theory called the time-dependent density-matrix theory (TDDM). The Skyrme force is used in the calculation of both a mean field and two-body correlations. It is found that TDDM gives reasonable ground-state correlations and a large spreading width of the E2 giant resonance when single-particle states in the continuum are treated appropriately. (author)

A Devil in the Details: Matrix-Dependent 40Ca42Ca++/42Ca+ and Its Effects on Estimates of the Initial 41Ca/40Ca in the Solar System

Science.gov (United States)

McKeegan, K. D.; Liu, M.-C.

2015-07-01

Ian Hutcheon established that the molecular ion interference 40Ca42Ca++/42Ca+ on 41K+ is strongly dependent on the mineral analyzed. Correction for this "matrix effect" led to a downward revision of the initial 41Ca/40Ca of the solar system.

Empirical method for matrix effects correction in liquid samples

International Nuclear Information System (INIS)

Vigoda de Leyt, Dora; Vazquez, Cristina

1987-01-01

A simple method for the determination of Cr, Ni and Mo in stainless steels is presented. In order to minimize the matrix effects, the conditions of liquid system to dissolve stainless steels chips has been developed. Pure element solutions were used as standards. Preparation of synthetic solutions with all the elements of steel and also mathematic corrections are avoided. It results in a simple chemical operation which simplifies the method of analysis. The variance analysis of the results obtained with steel samples show that the three elements may be determined from the comparison with the analytical curves obtained with the pure elements if the same parameters in the calibration curves are used. The accuracy and the precision were checked against other techniques using the British Chemical Standards of the Bureau of Anlysed Samples Ltd. (England). (M.E.L.) [es

Resistivity Correction Factor for the Four-Probe Method: Experiment II

Science.gov (United States)

Yamashita, Masato; Yamaguchi, Shoji; Nishii, Toshifumi; Kurihara, Hiroshi; Enjoji, Hideo

1989-05-01

Experimental verification of the theoretically derived resistivity correction factor F is presented. Factor F can be applied to a system consisting of a disk sample and a four-probe array. Measurements are made on isotropic graphite disks and crystalline ITO films. Factor F can correct the apparent variations of the data and lead to reasonable resistivities and sheet resistances. Here factor F is compared to other correction factors; i.e. FASTM and FJIS.

Max–min distance nonnegative matrix factorization

KAUST Repository

Wang, Jim Jing-Yan; Gao, Xin

2014-01-01

Nonnegative Matrix Factorization (NMF) has been a popular representation method for pattern classification problems. It tries to decompose a nonnegative matrix of data samples as the product of a nonnegative basis matrix and a nonnegative coefficient matrix. The columns of the coefficient matrix can be used as new representations of these data samples. However, traditional NMF methods ignore class labels of the data samples. In this paper, we propose a novel supervised NMF algorithm to improve the discriminative ability of the new representation by using the class labels. Using the class labels, we separate all the data sample pairs into within-class pairs and between-class pairs. To improve the discriminative ability of the new NMF representations, we propose to minimize the maximum distance of the within-class pairs in the new NMF space, and meanwhile to maximize the minimum distance of the between-class pairs. With this criterion, we construct an objective function and optimize it with regard to basis and coefficient matrices, and slack variables alternatively, resulting in an iterative algorithm. The proposed algorithm is evaluated on three pattern classification problems and experiment results show that it outperforms the state-of-the-art supervised NMF methods.

Max–min distance nonnegative matrix factorization

KAUST Repository

Wang, Jim Jing-Yan

2014-10-26

Nonnegative Matrix Factorization (NMF) has been a popular representation method for pattern classification problems. It tries to decompose a nonnegative matrix of data samples as the product of a nonnegative basis matrix and a nonnegative coefficient matrix. The columns of the coefficient matrix can be used as new representations of these data samples. However, traditional NMF methods ignore class labels of the data samples. In this paper, we propose a novel supervised NMF algorithm to improve the discriminative ability of the new representation by using the class labels. Using the class labels, we separate all the data sample pairs into within-class pairs and between-class pairs. To improve the discriminative ability of the new NMF representations, we propose to minimize the maximum distance of the within-class pairs in the new NMF space, and meanwhile to maximize the minimum distance of the between-class pairs. With this criterion, we construct an objective function and optimize it with regard to basis and coefficient matrices, and slack variables alternatively, resulting in an iterative algorithm. The proposed algorithm is evaluated on three pattern classification problems and experiment results show that it outperforms the state-of-the-art supervised NMF methods.

Determination of non-uniformity correction factors for cylindrical ionization chambers close to 192Ir brachytherapy sources

International Nuclear Information System (INIS)

Toelli, H.; Bielajew, A. F.; Mattsson, O.; Sernbo, G.

1995-01-01

When ionization chambers are used in brachytherapy dosimetry, the measurements must be corrected for the non-uniformity of the incident photon fluence. The theory for determination of non-uniformity correction factors, developed by Kondo and Randolph (Rad. Res. 1960) assumes that the electron fluence within the air cavity is isotropic and does not take into account material differences in the chamber wall. The theory was extended by Bielajew (PMB 1990) using an anisotropic electron angular fluence in the cavity. In contrast to the theory by Kondo and Randolph, the anisotropic theory predicts a wall material dependence in the non-uniformity correction factors. This work presents experimental determination of non-uniformity correction factors at distances between 10 and 140 mm from an Ir-192 source. The experimental work makes use of a PTW23331-chamber and Farmer-type chambers (NE2571 and NE2581) with different materials in the walls. The results of the experiments agree well with the anisotropic theory. Due to the geometrical shape of the NE-type chambers, it is shown that the full length of the these chambers, 24.1mm, is not an appropriate input parameter when theoretical non-uniformity correction factors are evaluated

Bias-corrected estimation of stable tail dependence function

DEFF Research Database (Denmark)

Beirlant, Jan; Escobar-Bach, Mikael; Goegebeur, Yuri

2016-01-01

We consider the estimation of the stable tail dependence function. We propose a bias-corrected estimator and we establish its asymptotic behaviour under suitable assumptions. The finite sample performance of the proposed estimator is evaluated by means of an extensive simulation study where...

HIGH DIMENSIONAL COVARIANCE MATRIX ESTIMATION IN APPROXIMATE FACTOR MODELS.

Science.gov (United States)

Fan, Jianqing; Liao, Yuan; Mincheva, Martina

2011-01-01

The variance covariance matrix plays a central role in the inferential theories of high dimensional factor models in finance and economics. Popular regularization methods of directly exploiting sparsity are not directly applicable to many financial problems. Classical methods of estimating the covariance matrices are based on the strict factor models, assuming independent idiosyncratic components. This assumption, however, is restrictive in practical applications. By assuming sparse error covariance matrix, we allow the presence of the cross-sectional correlation even after taking out common factors, and it enables us to combine the merits of both methods. We estimate the sparse covariance using the adaptive thresholding technique as in Cai and Liu (2011), taking into account the fact that direct observations of the idiosyncratic components are unavailable. The impact of high dimensionality on the covariance matrix estimation based on the factor structure is then studied.

Non-matrix corrected organic sulfur determination by energy dispersive X-ray spectroscopy for western Kentucky coals and residues

International Nuclear Information System (INIS)

Clark, C.P.; Freeman, G.B.; Hower, J.C.

1984-01-01

A method for non-matrix corrected organic sulfur analysis by energy dispersive X-ray spectroscopy has been developed using petroleum coke standards. Typically, electron beam microanalysis is a rapid, nondestructive analytical technique to quantitatively measure organic sulfur in coal. The results show good correlation to ASTM values for numerous well characterized coals with a wide range in total and pyritic sulfur content. This direct analysis is capable of reducing error commonly associated with the present ASTM method which relies on an indirect measure of organic sulfur by difference. The precision of the organic sulfur values determined in the present study is comparable to that obtained by ZAF matrix corrected microanalysis. The energy dispersive microanalysis is capable of measuring micro as well as bulk organic sulfur levels

Matrix factorization on a hypercube multiprocessor

International Nuclear Information System (INIS)

Geist, G.A.; Heath, M.T.

1985-08-01

This paper is concerned with parallel algorithms for matrix factorization on distributed-memory, message-passing multiprocessors, with special emphasis on the hypercube. Both Cholesky factorization of symmetric positive definite matrices and LU factorization of nonsymmetric matrices using partial pivoting are considered. The use of the resulting triangular factors to solve systems of linear equations by forward and back substitutions is also considered. Efficiencies of various parallel computational approaches are compared in terms of empirical results obtained on an Intel iPSC hypercube. 19 refs., 6 figs., 2 tabs

QED radiative corrections to impact factors

International Nuclear Information System (INIS)

Kuraev, E.A.; Lipatov, L.N.; Shishkina, T.V.

2001-01-01

We consider radiative corrections to the electron and photon impact factors. The generalized eikonal representation for the e + e - scattering amplitude at high energies and fixed momentum transfers is violated by nonplanar diagrams. An additional contribution to the two-loop approximation appears from the Bethe-Heitler mechanism of fermion pair production with the identity of the fermions in the final state taken into account. The violation of the generalized eikonal representation is also related to the charge parity conservation in QED. A one-loop correction to the photon impact factor for small virtualities of the exchanged photon is obtained using the known results for the cross section of the e + e - production during photon-nuclei interactions

Single-channel source separation using non-negative matrix factorization

DEFF Research Database (Denmark)

Schmidt, Mikkel Nørgaard

-determined and its solution relies on making appropriate assumptions concerning the sources. This dissertation is concerned with model-based probabilistic single-channel source separation based on non-negative matrix factorization, and consists of two parts: i) three introductory chapters and ii) five published...... papers. The first part introduces the single-channel source separation problem as well as non-negative matrix factorization and provides a comprehensive review of existing approaches, applications, and practical algorithms. This serves to provide context for the second part, the published papers......, in which a number of methods for single-channel source separation based on non-negative matrix factorization are presented. In the papers, the methods are applied to separating audio signals such as speech and musical instruments and separating different types of tissue in chemical shift imaging....

On affine non-negative matrix factorization

DEFF Research Database (Denmark)

Laurberg, Hans; Hansen, Lars Kai

2007-01-01

We generalize the non-negative matrix factorization (NMF) generative model to incorporate an explicit offset. Multiplicative estimation algorithms are provided for the resulting sparse affine NMF model. We show that the affine model has improved uniqueness properties and leads to more accurate id...

Calculation of the flux attenuation and multiple scattering correction factors in time of flight technique for double differential cross section measurements

International Nuclear Information System (INIS)

Martin, G.; Coca, M.; Capote, R.

1996-01-01

Using Monte Carlo method technique , a computer code which simulates the time of flight experiment to measure double differential cross section was developed. The correction factor for flux attenuation and multiple scattering, that make a deformation to the measured spectrum, were calculated. The energy dependence of the correction factor was determined and a comparison with other works is shown. Calculations for Fe 56 at two different scattering angles were made. We also reproduce the experiment performed at the Nuclear Analysis Laboratory for C 12 at 25 celsius degree and the calculated correction factor for the is measured is shown. We found a linear relation between the scatter size and the correction factor for flux attenuation

RSAT matrix-clustering: dynamic exploration and redundancy reduction of transcription factor binding motif collections.

Science.gov (United States)

Castro-Mondragon, Jaime Abraham; Jaeger, Sébastien; Thieffry, Denis; Thomas-Chollier, Morgane; van Helden, Jacques

2017-07-27

Transcription factor (TF) databases contain multitudes of binding motifs (TFBMs) from various sources, from which non-redundant collections are derived by manual curation. The advent of high-throughput methods stimulated the production of novel collections with increasing numbers of motifs. Meta-databases, built by merging these collections, contain redundant versions, because available tools are not suited to automatically identify and explore biologically relevant clusters among thousands of motifs. Motif discovery from genome-scale data sets (e.g. ChIP-seq) also produces redundant motifs, hampering the interpretation of results. We present matrix-clustering, a versatile tool that clusters similar TFBMs into multiple trees, and automatically creates non-redundant TFBM collections. A feature unique to matrix-clustering is its dynamic visualisation of aligned TFBMs, and its capability to simultaneously treat multiple collections from various sources. We demonstrate that matrix-clustering considerably simplifies the interpretation of combined results from multiple motif discovery tools, and highlights biologically relevant variations of similar motifs. We also ran a large-scale application to cluster ∼11 000 motifs from 24 entire databases, showing that matrix-clustering correctly groups motifs belonging to the same TF families, and drastically reduced motif redundancy. matrix-clustering is integrated within the RSAT suite (http://rsat.eu/), accessible through a user-friendly web interface or command-line for its integration in pipelines. © The Author(s) 2017. Published by Oxford University Press on behalf of Nucleic Acids Research.

Monte Carlo and experimental determination of correction factors for gamma knife perfexion small field dosimetry measurements

Science.gov (United States)

Zoros, E.; Moutsatsos, A.; Pappas, E. P.; Georgiou, E.; Kollias, G.; Karaiskos, P.; Pantelis, E.

2017-09-01

Detector-, field size- and machine-specific correction factors are required for precise dosimetry measurements in small and non-standard photon fields. In this work, Monte Carlo (MC) simulation techniques were used to calculate the k{{Qmsr},{{Q}0}}{{fmsr},{{f}ref}} and k{{Qclin},{{Q}msr}}{{fclin},{{f}msr}} correction factors for a series of ionization chambers, a synthetic microDiamond and diode dosimeters, used for reference and/or output factor (OF) measurements in the Gamma Knife Perfexion photon fields. Calculations were performed for the solid water (SW) and ABS plastic phantoms, as well as for a water phantom of the same geometry. MC calculations for the k{{Qclin},{{Q}msr}}{{fclin},{{f}msr}} correction factors in SW were compared against corresponding experimental results for a subset of ionization chambers and diode detectors. Reference experimental OF data were obtained through the weighted average of corresponding measurements using TLDs, EBT-2 films and alanine pellets. k{{Qmsr},{{Q}0}}{{fmsr},{{f}ref}} values close to unity (within 1%) were calculated for most of ionization chambers in water. Greater corrections of up to 6.0% were observed for chambers with relatively large air-cavity dimensions and steel central electrode. A phantom correction of 1.006 and 1.024 (breaking down to 1.014 from the ABS sphere and 1.010 from the accompanying ABS phantom adapter) were calculated for the SW and ABS phantoms, respectively, adding up to k{{Qmsr},{{Q}0}}{{fmsr},{{f}ref}} corrections in water. Both measurements and MC calculations for the diode and microDiamond detectors resulted in lower than unit k{{Qclin},{{Q}msr}}{{fclin},{{f}msr}} correction factors, due to their denser sensitive volume and encapsulation materials. In comparison, higher than unit k{{Qclin},{{Q}msr}}{{fclin},{{f}msr}} results for the ionization chambers suggested field size depended dose underestimations (being significant for the 4 mm field), with magnitude depending on the combination of

Determination of epithermal flux correction factor (α) for irradiation ...

African Journals Online (AJOL)

Due to resonance that occur in the epithermal energy region of a reactor, the flux spectra in that region deviates strongly from the ideal I/E law to a I/E1+α with alpha as the correction factor. The factor has to be determined if zirconium as monitor pairs to determine the correction factor for inner irradiation channel 5 and outer ...

Normalization Of Thermal-Radiation Form-Factor Matrix

Science.gov (United States)

Tsuyuki, Glenn T.

1994-01-01

Report describes algorithm that adjusts form-factor matrix in TRASYS computer program, which calculates intraspacecraft radiative interchange among various surfaces and environmental heat loading from sources such as sun.

Absorption correction factor in X-ray fluorescent quantitative analysis

International Nuclear Information System (INIS)

Pimjun, S.

1994-01-01

An experiment on absorption correction factor in X-ray fluorescent quantitative analysis were carried out. Standard samples were prepared from the mixture of Fe 2 O 3 and tapioca flour at various concentration of Fe 2 O 3 ranging from 5% to 25%. Unknown samples were kaolin containing 3.5% to-50% of Fe 2 O 3 Kaolin samples were diluted with tapioca flour in order to reduce the absorption of FeK α and make them easy to prepare. Pressed samples with 0.150 /cm 2 and 2.76 cm in diameter, were used in the experiment. Absorption correction factor is related to total mass absorption coefficient (χ) which varied with sample composition. In known sample, χ can be calculated by conveniently the formula. However in unknown sample, χ can be determined by Emission-Transmission method. It was found that the relationship between corrected FeK α intensity and contents of Fe 2 O 3 in these samples was linear. This result indicate that this correction factor can be used to adjust the accuracy of X-ray intensity. Therefore, this correction factor is essential in quantitative analysis of elements comprising in any sample by X-ray fluorescent technique

Sparse modeling of EELS and EDX spectral imaging data by nonnegative matrix factorization

Energy Technology Data Exchange (ETDEWEB)

Shiga, Motoki, E-mail: shiga_m@gifu-u.ac.jp [Department of Electrical, Electronic and Computer Engineering, Gifu University, 1-1, Yanagido, Gifu 501-1193 (Japan); Tatsumi, Kazuyoshi; Muto, Shunsuke [Advanced Measurement Technology Center, Institute of Materials and Systems for Sustainability, Nagoya University, Chikusa-ku, Nagoya 464-8603 (Japan); Tsuda, Koji [Graduate School of Frontier Sciences, University of Tokyo, 5-1-5 Kashiwanoha, Kashiwa 277-8561 (Japan); Center for Materials Research by Information Integration, National Institute for Materials Science, 1-2-1 Sengen, Tsukuba 305-0047 (Japan); Biotechnology Research Institute for Drug Discovery, National Institute of Advanced Industrial Science and Technology, 2-4-7 Aomi Koto-ku, Tokyo 135-0064 (Japan); Yamamoto, Yuta [High-Voltage Electron Microscope Laboratory, Institute of Materials and Systems for Sustainability, Nagoya University, Chikusa-ku, Nagoya 464-8603 (Japan); Mori, Toshiyuki [Environment and Energy Materials Division, National Institute for Materials Science, 1-1 Namiki, Tsukuba 305-0044 (Japan); Tanji, Takayoshi [Division of Materials Research, Institute of Materials and Systems for Sustainability, Nagoya University, Chikusa-ku, Nagoya 464-8603 (Japan)

2016-11-15

Advances in scanning transmission electron microscopy (STEM) techniques have enabled us to automatically obtain electron energy-loss (EELS)/energy-dispersive X-ray (EDX) spectral datasets from a specified region of interest (ROI) at an arbitrary step width, called spectral imaging (SI). Instead of manually identifying the potential constituent chemical components from the ROI and determining the chemical state of each spectral component from the SI data stored in a huge three-dimensional matrix, it is more effective and efficient to use a statistical approach for the automatic resolution and extraction of the underlying chemical components. Among many different statistical approaches, we adopt a non-negative matrix factorization (NMF) technique, mainly because of the natural assumption of non-negative values in the spectra and cardinalities of chemical components, which are always positive in actual data. This paper proposes a new NMF model with two penalty terms: (i) an automatic relevance determination (ARD) prior, which optimizes the number of components, and (ii) a soft orthogonal constraint, which clearly resolves each spectrum component. For the factorization, we further propose a fast optimization algorithm based on hierarchical alternating least-squares. Numerical experiments using both phantom and real STEM-EDX/EELS SI datasets demonstrate that the ARD prior successfully identifies the correct number of physically meaningful components. The soft orthogonal constraint is also shown to be effective, particularly for STEM-EELS SI data, where neither the spatial nor spectral entries in the matrices are sparse. - Highlights: • Automatic resolution of chemical components from spectral imaging is considered. • We propose a new non-negative matrix factorization with two new penalties. • The first penalty is sparseness to choose the number of components from data. • Experimental results with real data demonstrate effectiveness of our method.

Exercise identity as a risk factor for exercise dependence.

Science.gov (United States)

Murray, Aja L; McKenzie, Karen; Newman, Emily; Brown, Erin

2013-05-01

The aim of the study was to explore the relationship between exercise identity and exercise dependence. We hypothesized that stronger exercise identities would be associated with greater odds of experiencing exercise dependence symptoms. Logistic regression was used to assess the extent of association between exercise identity and the risk of experiencing exercise dependence symptoms. Participants (101) were recruited online via sports clubs and social networking sites and were asked to complete online measures of exercise identity and exercise dependence. The overall model fit was a significant improvement on the baseline model, but only the exercise beliefs factor was significantly associated with the odds of dependence symptoms, with higher scores on the belief scale predicting greater odds of experiencing dependence symptoms. Exercise role identity, in contrast, was not significantly associated with odds of experiencing dependence symptoms. Per cent correct classification was 55.9% for asymptomatic and 88.2% for symptomatic individuals and the overall per cent correct classification was 77.5%. The relation between identity and dependence could represent both a fruitful research avenue and a potential therapeutic target for those experiencing dependence symptoms; although our findings only showed a relationship between one of the two factors of the exercise identity measure and dependence. Longitudinal research is required to examine the relationship between identity and dependence in the context of other variables to better understand why some individuals become exercise dependent whereas others do not. What is already known on this subject? Exercise identity has been identified as an important determinant of exercise behaviour and studies within the exercise identity framework have proven elucidative with respect to the psychological processes that may underpin commitment to exercise. It has separately been established that some individuals may become

First Industrial Tests of a Drum Monitor Matrix Correction for the Fissile Mass Measurement in Large Volume Historic Metallic Residues with the Differential Die-away Technique

Energy Technology Data Exchange (ETDEWEB)

Antoni, R.; Passard, C.; Perot, B.; Batifol, M.; Vandamme, J.C. [CEA, DEN, Cadarache, Nuclear Measurement Laboratory, F-13108 St Paul-lez-Durance, (France); Grassi, G. [AREVA NC, 1 place Jean-Millier, 92084 Paris-La-Defense cedex (France)

2015-07-01

The fissile mass in radioactive waste drums filled with compacted metallic residues (spent fuel hulls and nozzles) produced at AREVA La Hague reprocessing plant is measured by neutron interrogation with the Differential Die-away measurement Technique (DDT. In the next years, old hulls and nozzles mixed with Ion-Exchange Resins will be measured. The ion-exchange resins increase neutron moderation in the matrix, compared to the waste measured in the current process. In this context, the Nuclear Measurement Laboratory (NML) of CEA Cadarache has studied a matrix effect correction method, based on a drum monitor ({sup 3}He proportional counter inside the measurement cavity). A previous study performed with the NML R and D measurement cell PROMETHEE 6 has shown the feasibility of method, and the capability of MCNP simulations to correctly reproduce experimental data and to assess the performances of the proposed correction. A next step of the study has focused on the performance assessment of the method on the industrial station using numerical simulation. A correlation between the prompt calibration coefficient of the {sup 239}Pu signal and the drum monitor signal was established using the MCNPX computer code and a fractional factorial experimental design composed of matrix parameters representative of the variation range of historical waste. Calculations have showed that the method allows the assay of the fissile mass with an uncertainty within a factor of 2, while the matrix effect without correction ranges on 2 decades. In this paper, we present and discuss the first experimental tests on the industrial ACC measurement system. A calculation vs. experiment benchmark has been achieved by performing dedicated calibration measurement with a representative drum and {sup 235}U samples. The preliminary comparison between calculation and experiment shows a satisfactory agreement for the drum monitor. The final objective of this work is to confirm the reliability of the

First Industrial Tests of a Drum Monitor Matrix Correction for the Fissile Mass Measurement in Large Volume Historic Metallic Residues with the Differential Die-away Technique

International Nuclear Information System (INIS)

Antoni, R.; Passard, C.; Perot, B.; Batifol, M.; Vandamme, J.C.; Grassi, G.

2015-01-01

The fissile mass in radioactive waste drums filled with compacted metallic residues (spent fuel hulls and nozzles) produced at AREVA La Hague reprocessing plant is measured by neutron interrogation with the Differential Die-away measurement Technique (DDT. In the next years, old hulls and nozzles mixed with Ion-Exchange Resins will be measured. The ion-exchange resins increase neutron moderation in the matrix, compared to the waste measured in the current process. In this context, the Nuclear Measurement Laboratory (NML) of CEA Cadarache has studied a matrix effect correction method, based on a drum monitor ( 3 He proportional counter inside the measurement cavity). A previous study performed with the NML R and D measurement cell PROMETHEE 6 has shown the feasibility of method, and the capability of MCNP simulations to correctly reproduce experimental data and to assess the performances of the proposed correction. A next step of the study has focused on the performance assessment of the method on the industrial station using numerical simulation. A correlation between the prompt calibration coefficient of the 239 Pu signal and the drum monitor signal was established using the MCNPX computer code and a fractional factorial experimental design composed of matrix parameters representative of the variation range of historical waste. Calculations have showed that the method allows the assay of the fissile mass with an uncertainty within a factor of 2, while the matrix effect without correction ranges on 2 decades. In this paper, we present and discuss the first experimental tests on the industrial ACC measurement system. A calculation vs. experiment benchmark has been achieved by performing dedicated calibration measurement with a representative drum and 235 U samples. The preliminary comparison between calculation and experiment shows a satisfactory agreement for the drum monitor. The final objective of this work is to confirm the reliability of the modeling approach

Matrix factorizations, minimal models and Massey products

International Nuclear Information System (INIS)

Knapp, Johanna; Omer, Harun

2006-01-01

We present a method to compute the full non-linear deformations of matrix factorizations for ADE minimal models. This method is based on the calculation of higher products in the cohomology, called Massey products. The algorithm yields a polynomial ring whose vanishing relations encode the obstructions of the deformations of the D-branes characterized by these matrix factorizations. This coincides with the critical locus of the effective superpotential which can be computed by integrating these relations. Our results for the effective superpotential are in agreement with those obtained from solving the A-infinity relations. We point out a relation to the superpotentials of Kazama-Suzuki models. We will illustrate our findings by various examples, putting emphasis on the E 6 minimal model

Enforced Sparse Non-Negative Matrix Factorization

Science.gov (United States)

2016-01-23

proposals quotas opec legislation revenue england ico iraq vote passenger yen producer iranian surplus Figure 4. Example NMF with and without sparsity...preprint arXiv:1007.0380, 2010. [22] A. Cichocki and P. Anh-Huy, “Fast local algorithms for large scale nonnegative matrix and tensor factorizations

Multiple graph regularized nonnegative matrix factorization

KAUST Repository

Wang, Jim Jing-Yan

2013-10-01

Non-negative matrix factorization (NMF) has been widely used as a data representation method based on components. To overcome the disadvantage of NMF in failing to consider the manifold structure of a data set, graph regularized NMF (GrNMF) has been proposed by Cai et al. by constructing an affinity graph and searching for a matrix factorization that respects graph structure. Selecting a graph model and its corresponding parameters is critical for this strategy. This process is usually carried out by cross-validation or discrete grid search, which are time consuming and prone to overfitting. In this paper, we propose a GrNMF, called MultiGrNMF, in which the intrinsic manifold is approximated by a linear combination of several graphs with different models and parameters inspired by ensemble manifold regularization. Factorization metrics and linear combination coefficients of graphs are determined simultaneously within a unified object function. They are alternately optimized in an iterative algorithm, thus resulting in a novel data representation algorithm. Extensive experiments on a protein subcellular localization task and an Alzheimer\\'s disease diagnosis task demonstrate the effectiveness of the proposed algorithm. © 2013 Elsevier Ltd. All rights reserved.

Correction factor for hair analysis by PIXE

International Nuclear Information System (INIS)

Montenegro, E.C.; Baptista, G.B.; Castro Faria, L.V. de; Paschoa, A.S.

1980-01-01

The application of the Particle Induced X-ray Emission (PIXE) technique to analyse quantitatively the elemental composition of hair specimens brings about some difficulties in the interpretation of the data. The present paper proposes a correction factor to account for the effects of the energy loss of the incident particle with penetration depth, and X-ray self-absorption when a particular geometrical distribution of elements in hair is assumed for calculational purposes. The correction factor has been applied to the analysis of hair contents Zn, Cu and Ca as a function of the energy of the incident particle. (orig.)

Correction factor for hair analysis by PIXE

International Nuclear Information System (INIS)

Montenegro, E.C.; Baptista, G.B.; Castro Faria, L.V. de; Paschoa, A.S.

1979-06-01

The application of the Particle Induced X-ray Emission (PIXE) technique to analyse quantitatively the elemental composition of hair specimens brings about some difficulties in the interpretation of the data. The present paper proposes a correction factor to account for the effects of energy loss of the incident particle with penetration depth, and x-ray self-absorption when a particular geometrical distribution of elements in hair is assumed for calculational purposes. The correction factor has been applied to the analysis of hair contents Zn, Cu and Ca as a function of the energy of the incident particle.(Author) [pt

Estimating Depolarization with the Jones Matrix Quality Factor

Science.gov (United States)

Hilfiker, James N.; Hale, Jeffrey S.; Herzinger, Craig M.; Tiwald, Tom; Hong, Nina; Schöche, Stefan; Arwin, Hans

2017-11-01

Mueller matrix (MM) measurements offer the ability to quantify the depolarization capability of a sample. Depolarization can be estimated using terms such as the depolarization index or the average degree of polarization. However, these calculations require measurement of the complete MM. We propose an alternate depolarization metric, termed the Jones matrix quality factor, QJM, which does not require the complete MM. This metric provides a measure of how close, in a least-squares sense, a Jones matrix can be found to the measured Mueller matrix. We demonstrate and compare the use of QJM to other traditional calculations of depolarization for both isotropic and anisotropic depolarizing samples; including non-uniform coatings, anisotropic crystal substrates, and beetle cuticles that exhibit both depolarization and circular diattenuation.

Correction factors for the NMi free-air ionization chamber for medium-energy x-rays calculated with the Monte Carlo method

International Nuclear Information System (INIS)

Grimbergen, T.W.M.; Dijk, E. van; Vries, W. de

1998-01-01

A new method is described for the determination of x-ray quality dependent correction factors for free-air ionization chambers. The method is based on weighting correction factors for mono-energetic photons, which are calculated using the Monte Carlo method, with measured air kerma spectra. With this method, correction factors for electron loss, scatter inside the chamber and transmission through the diaphragm and front wall have been calculated for the NMi free-air chamber for medium-energy x-rays for a wide range of x-ray qualities in use at NMi. The newly obtained correction factors were compared with the values in use at present, which are based on interpolation of experimental data for a specific set of x-ray qualities. For x-ray qualities which are similar to this specific set, the agreement between the correction factors determined with the new method and those based on the experimental data is better than 0.1%, except for heavily filtered x-rays generated at 250 kV. For x-ray qualities dissimilar to the specific set, differences up to 0.4% exist, which can be explained by uncertainties in the interpolation procedure of the experimental data. Since the new method does not depend on experimental data for a specific set of x-ray qualities, the new method allows for a more flexible use of the free-air chamber as a primary standard for air kerma for any x-ray quality in the medium-energy x-ray range. (author)

77 FR 22565 - Advisory Council on Dependents' Education; Open Meeting Notice; Correction

Science.gov (United States)

2012-04-16

... DEPARTMENT OF DEFENSE Office of the Secretary Advisory Council on Dependents' Education; Open Meeting Notice; Correction AGENCY: Department of Defense Education Activity (DoDEA), DoD. ACTION: Open meeting notice; correction. SUMMARY: On February 28, 2012 (77 FR 12039), the Advisory Council on...

Fibroblast growth factor receptor 4 regulates tumor invasion by coupling fibroblast growth factor signaling to extracellular matrix degradation

DEFF Research Database (Denmark)

Sugiyama, Nami; Varjosalo, Markku; Meller, Pipsa

2010-01-01

/stroma border and tumor invasion front. The strongest overall coexpression was found in prostate carcinoma. Studies with cultured prostate carcinoma cell lines showed that the FGFR4-R388 variant, which has previously been associated with poor cancer prognosis, increased MT1-MMP-dependent collagen invasion......Aberrant expression and polymorphism of fibroblast growth factor receptor 4 (FGFR4) has been linked to tumor progression and anticancer drug resistance. We describe here a novel mechanism of tumor progression by matrix degradation involving epithelial-to-mesenchymal transition in response...... to membrane-type 1 matrix metalloproteinase (MT1-MMP, MMP-14) induction at the edge of tumors expressing the FGFR4-R388 risk variant. Both FGFR4 and MT1-MMP were upregulated in tissue biopsies from several human cancer types including breast adenocarcinomas, where they were partially coexpressed at the tumor...

Laboratory Experiments to Evaluate Diffusion of 14C into Nevada Test Site Carbonate Aquifer Matrix

Energy Technology Data Exchange (ETDEWEB)

Ronald L. Hershey; William Howcroft; Paul W. Reimus

2003-03-01

Determination of groundwater flow velocities at the Nevada Test Site is important since groundwater is the principal transport medium of underground radionuclides. However, 14C-based groundwater velocities in the carbonate aquifers of the Nevada Test Site are several orders of magnitude slower than velocities derived from the Underground Test Area regional numerical model. This discrepancy has been attributed to the loss or retardation of 14C from groundwater into the surrounding aquifer matrix making 14C-based groundwater ages appear much older. Laboratory experiments were used to investigate the retardation of 14C in the carbonate aquifers at the Nevada Test Site. Three sets of experiments were conducted evaluating the diffusion of 14C into the carbonate aquifer matrix, adsorption and/or isotopic exchange onto the pore surfaces of the carbonate matrix, and adsorption and/or isotopic exchange onto the fracture surfaces of the carbonate aquifer. Experimental results a nd published aquifer matrix and fracture porosities from the Lower Carbonate Aquifer were applied to a 14C retardation model. The model produced an extremely wide range of retardation factors because of the wide range of published aquifer matrix and fracture porosities (over three orders of magnitude). Large retardation factors suggest that groundwater with very little measured 14C activity may actually be very young if matrix porosity is large relative to the fracture porosity. Groundwater samples collected from highly fractured aquifers with large effective fracture porosities may have relatively small correction factors, while samples from aquifers with a few widely spaced fractures may have very large correction factors. These retardation factors were then used to calculate groundwater velocities from a proposed flow path at the Nevada Test Site. The upper end of the range of 14C correction factors estimated groundwater velocities that appear to be at least an order of magnitude too high compared

Two-loop massive fermionic operator matrix elements and intial state QED corrections to e{sup +}e{sup -}{yields}{gamma}{sup *}/Z{sup *}

Energy Technology Data Exchange (ETDEWEB)

Bluemlein, J. [Deutsches Elektronen-Synchrotron (DESY), Zeuthen (Germany); Freitas, A. de [Deutsches Elektronen-Synchrotron (DESY), Zeuthen (Germany)]|[Universidad Simon Bolivar, Caracas (Venezuela). Dept. de Fisica; Neerven, W. van [Leiden Univ. (Netherlands). Lorentz Institute

2008-12-15

We describe the calculation of the two-loop massive operator matrix elements for massive external fermions. These matrix elements are needed for the calculation of the O({alpha}{sup 2}) initial state radiative corrections to e{sup +}e{sup -} annihilation into a neutral virtual gauge boson, based on the renormalization group technique. (orig.)

Economic benefits of power factor correction at a nuclear facility

International Nuclear Information System (INIS)

Boger, R.M.; Dalos, W.; Juguilon, M.E.

1986-01-01

The economic benefits of correcting poor power factor at an operating nuclear facility are shown. A project approach for achieving rapid return of investment without disrupting plant availability is described. Examples of technical problems associated with using capacitors for power factor correction are presented

Extracellular matrix organization modulates fibroblast growth and growth factor responsiveness.

Science.gov (United States)

Nakagawa, S; Pawelek, P; Grinnell, F

1989-06-01

To learn more about the relationship between extracellular matrix organization, cell shape, and cell growth control, we studied DNA synthesis by fibroblasts in collagen gels that were either attached to culture dishes or floating in culture medium during gel contraction. After 4 days of contraction, the collagen density (initially 1.5 mg/ml) reached 22 mg/ml in attached gels and 55 mg/ml in floating gels. After contraction, attached collagen gels were well organized; collagen fibrils were aligned in the plane of cell spreading; and fibroblasts had an elongated, bipolar morphology. Floating collagen gels, however, were unorganized; collagen fibrils were arranged randomly; and fibroblasts had a stellate morphology. DNA synthesis by fibroblasts in contracted collagen gels was suppressed if the gels were floating in medium but not if the gels were attached, and inhibition was independent of the extent of gel contraction. Therefore, growth of fibroblasts in contracted collagen gels could be regulated by differences in extracellular matrix organization and cell shape independently of extracellular matrix density. We also compared the responses of fibroblasts in contracted collagen gels and monolayer culture to peptide growth factors including fibroblast growth factor, platelet-derived growth factor, transforming growth factor-beta, and interleukin 1. Cells in floating collagen gels were generally unresponsive to any of the growth factors. Cells in attached collagen gels and monolayer culture were affected similarly by fibroblast growth factor but not by the others. Our results indicate that extracellular matrix organization influenced not only cell growth, but also fibroblast responsiveness to peptide growth factors.

Spectral correction factors for conventional neutron dosemeters used in high-energy neutron environments

International Nuclear Information System (INIS)

Lee, K.W.; Sheu, R.J.

2015-01-01

High-energy neutrons (>10 MeV) contribute substantially to the dose fraction but result in only a small or negligible response in most conventional moderated-type neutron detectors. Neutron dosemeters used for radiation protection purpose are commonly calibrated with 252 Cf neutron sources and are used in various workplace. A workplace-specific correction factor is suggested. In this study, the effect of the neutron spectrum on the accuracy of dose measurements was investigated. A set of neutron spectra representing various neutron environments was selected to study the dose responses of a series of Bonner spheres, including standard and extended-range spheres. By comparing 252 Cf-calibrated dose responses with reference values based on fluence-to-dose conversion coefficients, this paper presents recommendations for neutron field characterisation and appropriate correction factors for responses of conventional neutron dosemeters used in environments with high-energy neutrons. The correction depends on the estimated percentage of high-energy neutrons in the spectrum or the ratio between the measured responses of two Bonner spheres (the 4P6-8 extended-range sphere versus the 6'' standard sphere). (authors)

Effects of Velocity-Dependent Force on the Magnetic Form Factors of Odd-Z Nuclei

International Nuclear Information System (INIS)

Tie-Kuang, Dong; Zhong-Zhou, Ren

2008-01-01

We investigate the effects of the velocity-dependent force on the magnetic form factors and magnetic moments of odd-Z nuclei. The form factors are calculated with the harmonic-oscillator wavefunctions. It is found that the contributions of the velocity-dependent force manifest themselves in the very large momentum transfer region (q ≥ 4fm- 1 ). In the low and medium q region the contributions of the velocity-dependent force are very small compared with those without this force. However, in the high-q region the contributions of the velocity-dependent force are larger than the normal form factors. The diffraction structures beyond the existing experimental data are found after the contributions of the velocity-dependent force are included. The formula of the correction to the single particle magnetic moment due to the velocity-dependent force is reproduced exactly in the long-wavelength limit (q = 0) of the M1 form factor

A hierarchical model for ordinal matrix factorization

DEFF Research Database (Denmark)

Paquet, Ulrich; Thomson, Blaise; Winther, Ole

2012-01-01

This paper proposes a hierarchical probabilistic model for ordinal matrix factorization. Unlike previous approaches, we model the ordinal nature of the data and take a principled approach to incorporating priors for the hidden variables. Two algorithms are presented for inference, one based...

TRASYS form factor matrix normalization

Science.gov (United States)

Tsuyuki, Glenn T.

1992-01-01

A method has been developed for adjusting a TRASYS enclosure form factor matrix to unity. This approach is not limited to closed geometries, and in fact, it is primarily intended for use with open geometries. The purpose of this approach is to prevent optimistic form factors to space. In this method, nodal form factor sums are calculated within 0.05 of unity using TRASYS, although deviations as large as 0.10 may be acceptable, and then, a process is employed to distribute the difference amongst the nodes. A specific example has been analyzed with this method, and a comparison was performed with a standard approach for calculating radiation conductors. In this comparison, hot and cold case temperatures were determined. Exterior nodes exhibited temperature differences as large as 7 C and 3 C for the hot and cold cases, respectively when compared with the standard approach, while interior nodes demonstrated temperature differences from 0 C to 5 C. These results indicate that temperature predictions can be artificially biased if the form factor computation error is lumped into the individual form factors to space.

First determination of the quark mixing matrix element $V_{tb}$ from electroweak corrections to Z decays and implications for CKM matrix unitarity

CERN Document Server

Swain, J D

1999-01-01

We present a new method for the determination of the Cabibbo- Kobayashi-Maskawa quark mixing matrix element V/sub tb/ from electroweak loop corrections, in particular those affecting the process Z to bb. From a combined analysis of results from the LEP, SLC, Tevatron, and neutrino scattering experiments we determine V /sub tb/=0.77/sub -0.24//sup +18/. We comment briefly on the implications of this measurement for the mass of the top quark and Higgs boson, alpha /sub s/, and CKM unitarity. (19 refs).

Followee recommendation in microblog using matrix factorization model with structural regularization.

Science.gov (United States)

Yu, Yan; Qiu, Robin G

2014-01-01

Microblog that provides us a new communication and information sharing platform has been growing exponentially since it emerged just a few years ago. To microblog users, recommending followees who can serve as high quality information sources is a competitive service. To address this problem, in this paper we propose a matrix factorization model with structural regularization to improve the accuracy of followee recommendation in microblog. More specifically, we adapt the matrix factorization model in traditional item recommender systems to followee recommendation in microblog and use structural regularization to exploit structure information of social network to constrain matrix factorization model. The experimental analysis on a real-world dataset shows that our proposed model is promising.

Parallelized preconditioned model building algorithm for matrix factorization

OpenAIRE

Kaya, Kamer; Birbil, İlker; Birbil, Ilker; Öztürk, Mehmet Kaan; Ozturk, Mehmet Kaan; Gohari, Amir

2017-01-01

Matrix factorization is a common task underlying several machine learning applications such as recommender systems, topic modeling, or compressed sensing. Given a large and possibly sparse matrix A, we seek two smaller matrices W and H such that their product is as close to A as possible. The objective is minimizing the sum of square errors in the approximation. Typically such problems involve hundreds of thousands of unknowns, so an optimizer must be exceptionally efficient. In this study, a...

Depolarization artifacts in dual rotating-compensator Mueller matrix ellipsometry

International Nuclear Information System (INIS)

Li, Weiqi; Zhang, Chuanwei; Jiang, Hao; Chen, Xiuguo; Liu, Shiyuan

2016-01-01

Noticeable depolarization effects are observed in the measurement of the air using an in-house developed dual rotating-compensator Mueller matrix ellipsometer. We demonstrate that these depolarization effects are essentially artifacts and mainly induced when the compensator with wavelength-dependent optical properties is integrated with the finite bandwidth detector. We define a general formula to represent the actual Mueller matrix of the compensator by taking into account the depolarization artifacts. After incorporating this formula into the system model, a correction method is further proposed, and consequently, improved accuracy can be achieved in the Mueller matrix measurement. (paper)

Massive IIA string theory and Matrix theory compactification

International Nuclear Information System (INIS)

Lowe, David A.; Nastase, Horatiu; Ramgoolam, Sanjaye

2003-01-01

We propose a Matrix theory approach to Romans' massive Type IIA supergravity. It is obtained by applying the procedure of Matrix theory compactifications to Hull's proposal of the massive Type IIA string theory as M-theory on a twisted torus. The resulting Matrix theory is a super-Yang-Mills theory on large N three-branes with a space-dependent noncommutativity parameter, which is also independently derived by a T-duality approach. We give evidence showing that the energies of a class of physical excitations of the super-Yang-Mills theory show the correct symmetry expected from massive Type IIA string theory in a lightcone quantization

Volume correction factor in time dose relationships in brachytherapy

International Nuclear Information System (INIS)

Supe, S.J.; Sasane, J.B.

1987-01-01

Paterson's clinical data about the maximum tolerance doses for various volumes of interstitial implants with Ra-226 delivered in seven days was made use of in deriving volume correction factors for TDF and CRE concepts respectively for brachytherapy. The derived volume correction factors for TDF and for CRE differ fromthe one assumed for CRE by Kirk et al. and implied for TDF by Goitein. A normalising volume of 70 cc has been suggested for both CRE and TDF concepts for brachytherapy. A table showing the volume corrected TDF is presented for various volumes and dose rates for continuous irradiation. The use of this table is illustrated with examples. (orig.) [de

Dependence of electromagnetic form factors of hadrons on light-cone frames

International Nuclear Information System (INIS)

Weber, H.J.; Xu Xiaoming; Chinese Acad. of Sci., Shanghai

1996-01-01

A constituent quark model is developed for an arbitrary light-cone direction so that the light-front time is x LF + =ω.x with a constant lightlike four-vector ω. Form factors are obtained from free one-body electromagnetic current matrix elements. They are found to be ω-independent for spin-0 mesons, nucleons and the Λ-hyperon, while there is an ω-dependence for spin-1 systems like the deuteron. (orig.)

Wiener-Hopf factorization of piecewise meromorphic matrix-valued functions

International Nuclear Information System (INIS)

Adukov, Victor M

2009-01-01

Let D + be a multiply connected domain bounded by a contour Γ, let D - be the complement of D + union Γ in C-bar=C union {∞}, and a(t) be a continuous invertible matrix-valued function on Γ which can be meromorphically extended into the open disconnected set D - (as a piecewise meromorphic matrix-valued function). An explicit solution of the Wiener-Hopf factorization problem for a(t) is obtained and the partial factorization indices of a(t) are calculated. Here an explicit solution of a factorization problem is meant in the sense of reducing it to the investigation of finitely many systems of linear algebraic equations with matrices expressed in closed form, that is, in quadratures. Bibliography: 15 titles.

Derivation of Batho's correction factor for heterogeneities

International Nuclear Information System (INIS)

Lulu, B.A.; Bjaerngard, B.E.

1982-01-01

Batho's correction factor for dose in a heterogeneous, layered medium is derived from the tissue--air ratio method (TARM). The reason why the Batho factor is superior to the TARM factor at low energy is ascribed to the fact that it accounts for the distribution of the scatter-generating matter along the centerline. The poor behavior of the Batho factor at high energies is explained as a consequence of the lack of electron equilibrium at appreciable depth below the surface. Key words: Batho factor, heterogeneity, inhomogeneity, tissue--air ratio method

Modeling cometary photopolarimetric characteristics with Sh-matrix method

Science.gov (United States)

Kolokolova, L.; Petrov, D.

2017-12-01

Cometary dust is dominated by particles of complex shape and structure, which are often considered as fractal aggregates. Rigorous modeling of light scattering by such particles, even using parallelized codes and NASA supercomputer resources, is very computer time and memory consuming. We are presenting a new approach to modeling cometary dust that is based on the Sh-matrix technique (e.g., Petrov et al., JQSRT, 112, 2012). This method is based on the T-matrix technique (e.g., Mishchenko et al., JQSRT, 55, 1996) and was developed after it had been found that the shape-dependent factors could be separated from the size- and refractive-index-dependent factors and presented as a shape matrix, or Sh-matrix. Size and refractive index dependences are incorporated through analytical operations on the Sh-matrix to produce the elements of T-matrix. Sh-matrix method keeps all advantages of the T-matrix method, including analytical averaging over particle orientation. Moreover, the surface integrals describing the Sh-matrix elements themselves can be solvable analytically for particles of any shape. This makes Sh-matrix approach an effective technique to simulate light scattering by particles of complex shape and surface structure. In this paper, we present cometary dust as an ensemble of Gaussian random particles. The shape of these particles is described by a log-normal distribution of their radius length and direction (Muinonen, EMP, 72, 1996). Changing one of the parameters of this distribution, the correlation angle, from 0 to 90 deg., we can model a variety of particles from spheres to particles of a random complex shape. We survey the angular and spectral dependencies of intensity and polarization resulted from light scattering by such particles, studying how they depend on the particle shape, size, and composition (including porous particles to simulate aggregates) to find the best fit to the cometary observations.

Mitigation of voltage sag, swell and power factor correction using solid-state transformer b

Directory of Open Access Journals (Sweden)

M.R. Banaei

2014-09-01

Full Text Available This paper presents a novel topology of solid-state transformer (SST. In the design process, the AC/DC, DC/AC and AC/AC converters have been integrated to achieve higher efficiency. To obtain higher efficiency from other SST with DC-link topologies, the AC/DC and DC/AC converters have been integrated in one matrix converter. The proposed SST performs typical functions and has advantages such as power factor correction, voltage sag and swell elimination, voltage flicker reduction and protection capability in fault situations. In addition, it has other benefits such as light weight, low volume and elimination of hazardous liquid dielectrics because it uses medium frequency transformer. The operation and some performances of the proposed SST have been verified by the simulation results.

Power corrections to the asymptotics of the pion electromagnetic formfactor

International Nuclear Information System (INIS)

Gorsky, A.S.

1984-01-01

The first power correction to the pion electromagnetic form factor is derived. A few asymptotic wave functions corresponding to the different series of operators and matrix elements of four-particle operators in pion have been found. The large scale of the first power correction approximately 10 2 (GeV 2 )/Q 2 where Q 2 is the momentum transfer indicates that at low energies the whole series of power corrections seems to be taken into account

Multiplicative algorithms for constrained non-negative matrix factorization

KAUST Repository

Peng, Chengbin; Wong, Kachun; Rockwood, Alyn; Zhang, Xiangliang; Jiang, Jinling; Keyes, David E.

2012-01-01

Non-negative matrix factorization (NMF) provides the advantage of parts-based data representation through additive only combinations. It has been widely adopted in areas like item recommending, text mining, data clustering, speech denoising, etc

Watching excitons move: the time-dependent transition density matrix

Science.gov (United States)

Ullrich, Carsten

2012-02-01

Time-dependent density-functional theory allows one to calculate excitation energies and the associated transition densities in principle exactly. The transition density matrix (TDM) provides additional information on electron-hole localization and coherence of specific excitations of the many-body system. We have extended the TDM concept into the real-time domain in order to visualize the excited-state dynamics in conjugated molecules. The time-dependent TDM is defined as an implicit density functional, and can be approximately obtained from the time-dependent Kohn-Sham orbitals. The quality of this approximation is assessed in simple model systems. A computational scheme for real molecular systems is presented: the time-dependent Kohn-Sham equations are solved with the OCTOPUS code and the time-dependent Kohn-Sham TDM is calculated using a spatial partitioning scheme. The method is applied to show in real time how locally created electron-hole pairs spread out over neighboring conjugated molecular chains. The coupling mechanism, electron-hole coherence, and the possibility of charge separation are discussed.

Color correction optimization with hue regularization

Science.gov (United States)

Zhang, Heng; Liu, Huaping; Quan, Shuxue

2011-01-01

Previous work has suggested that observers are capable of judging the quality of an image without any knowledge of the original scene. When no reference is available, observers can extract the apparent objects in an image and compare them with the typical colors of similar objects recalled from their memories. Some generally agreed upon research results indicate that although perfect colorimetric rendering is not conspicuous and color errors can be well tolerated, the appropriate rendition of certain memory colors such as skin, grass, and sky is an important factor in the overall perceived image quality. These colors are appreciated in a fairly consistent manner and are memorized with slightly different hues and higher color saturation. The aim of color correction for a digital color pipeline is to transform the image data from a device dependent color space to a target color space, usually through a color correction matrix which in its most basic form is optimized through linear regressions between the two sets of data in two color spaces in the sense of minimized Euclidean color error. Unfortunately, this method could result in objectionable distortions if the color error biased certain colors undesirably. In this paper, we propose a color correction optimization method with preferred color reproduction in mind through hue regularization and present some experimental results.

Global unitary fixing and matrix-valued correlations in matrix models

International Nuclear Information System (INIS)

Adler, Stephen L.; Horwitz, Lawrence P.

2003-01-01

We consider the partition function for a matrix model with a global unitary invariant energy function. We show that the averages over the partition function of global unitary invariant trace polynomials of the matrix variables are the same when calculated with any choice of a global unitary fixing, while averages of such polynomials without a trace define matrix-valued correlation functions, that depend on the choice of unitary fixing. The unitary fixing is formulated within the standard Faddeev-Popov framework, in which the squared Vandermonde determinant emerges as a factor of the complete Faddeev-Popov determinant. We give the ghost representation for the FP determinant, and the corresponding BRST invariance of the unitary-fixed partition function. The formalism is relevant for deriving Ward identities obeyed by matrix-valued correlation functions

Spatially dependent burnup implementation into the nodal program based on the finite element response matrix method

International Nuclear Information System (INIS)

Yoriyaz, H.

1986-01-01

In this work a spatial burnup scheme and feedback effects has been implemented into the FERM ( 'Finite Element Response Matrix' )program. The spatially dependent neutronic parameters have been considered in three levels: zonewise calculation, assembly wise calculation and pointwise calculation. Flux and power distributions and the multiplication factor were calculated and compared with the results obtained by CITATIOn program. These comparisons showed that processing time in the Ferm code has been hundred of times shorter and no significant difference has been observed in the assembly average power distribution. (Author) [pt

Time dependent mean field approximation to the many-body S-matrix

International Nuclear Information System (INIS)

Alhassid, Y.; Koonin, S.E.

1980-01-01

Time-dependent Hartree-Fock (TDHF) calculations are a good description of some inclusive properties of deep inelastic heavy-ion collisions. The first steps toward a mean-field theory that approximates specific elements of the many-body S matrix are presented. A many-body system with pairwise interactions excited by an external, time-dependent one-body field is considered. The methods are used to solve the forced Lipkin model. The moduli of elastic and excitation amplitudes are plotted. 3 figures

Form factors in quantum integrable models with GL(3)-invariant R-matrix

Energy Technology Data Exchange (ETDEWEB)

Pakuliak, S., E-mail: pakuliak@theor.jinr.ru [Laboratory of Theoretical Physics, JINR, 141980 Dubna, Moscow Reg. (Russian Federation); Moscow Institute of Physics and Technology, 141700 Dolgoprudny, Moscow Reg. (Russian Federation); Institute of Theoretical and Experimental Physics, 117259 Moscow (Russian Federation); Ragoucy, E., E-mail: eric.ragoucy@lapth.cnrs.fr [Laboratoire de Physique Théorique LAPTH, CNRS and Université de Savoie, BP 110, 74941 Annecy-le-Vieux Cedex (France); Slavnov, N.A., E-mail: nslavnov@mi.ras.ru [Steklov Mathematical Institute, Moscow (Russian Federation)

2014-04-15

We study integrable models solvable by the nested algebraic Bethe ansatz and possessing GL(3)-invariant R-matrix. We obtain determinant representations for form factors of off-diagonal entries of the monodromy matrix. These representations can be used for the calculation of form factors and correlation functions of the XXX SU(3)-invariant Heisenberg chain.

Evaluation of off-axis wedge correction factor using diode dosimeters for estimation of delivered dose in external radiotherapy

International Nuclear Information System (INIS)

Allahverdi, Mahmoud; Shirazi, Alireza; Geraily, Ghazale; Mohammadkarim, Alireza; Esfehani, Mahbod; Nedaie, Hasanali

2012-01-01

An in vivo dosimetry system, using p-type diode dosimeters, was characterized for clinical applications of treatment machines ranging in megavoltage energies. This paper investigates two different models of diodes for externally wedged beams and explains a new algorithm for the calculation of the target dose at various tissue depths in external radiotherapy. The values of off-axis wedge correction factors were determined at two different positions in the wedged (toward the thick and thin edges) and in the non-wedged directions on entrance and exit surfaces of a polystyrene phantom in 60 Co and 6 MV photon beams. Depth transmission was defined on the entrance and exit surfaces to obtain the off-axis wedge correction factor at any depth. As the sensitivity of the diodes depends on physical characteristics (field size, source-skin distance (SSD), thickness, backscatter), correction factors were applied to the diode reading when measuring conditions different from calibration situations. The results indicate that needful correction factors for 60 Co wedged photons are usually larger than those for 6 MV wedged photon beams. In vivo dosimetry performed with the proposed algorithms at externally wedged beams has negligible probable errors (less than 0.5%) and is a reliable method for patient dose control. (author)

Evaluation of off-axis wedge correction factor using diode dosimeters for estimation of delivered dose in external radiotherapy

Directory of Open Access Journals (Sweden)

Mahmoud Allahverdi

2012-01-01

Full Text Available An in vivo dosimetry system, using p-type diode dosimeters, was characterized for clinical applications of treatment machines ranging in megavoltage energies. This paper investigates two different models of diodes for externally wedged beams and explains a new algorithm for the calculation of the target dose at various tissue depths in external radiotherapy. The values of off-axis wedge correction factors were determined at two different positions in the wedged (toward the thick and thin edges and in the non-wedged directions on entrance and exit surfaces of a polystyrene phantom in 60 Co and 6 MV photon beams. Depth transmission was defined on the entrance and exit surfaces to obtain the off-axis wedge correction factor at any depth. As the sensitivity of the diodes depends on physical characteristics [field size, source-skin distance (SSD, thickness, backscatter], correction factors were applied to the diode reading when measuring conditions different from calibration situations . The results indicate that needful correction factors for 60 Co wedged photons are usually larger than those for 6 MV wedged photon beams. In vivo dosimetry performed with the proposed algorithms at externally wedged beams has negligible probable errors (less than 0.5% and is a reliable method for patient dose control.

Multiple Kernel Learning for adaptive graph regularized nonnegative matrix factorization

KAUST Repository

Wang, Jim Jing-Yan; AbdulJabbar, Mustafa Abdulmajeed

2012-01-01

Nonnegative Matrix Factorization (NMF) has been continuously evolving in several areas like pattern recognition and information retrieval methods. It factorizes a matrix into a product of 2 low-rank non-negative matrices that will define parts-based, and linear representation of non-negative data. Recently, Graph regularized NMF (GrNMF) is proposed to find a compact representation, which uncovers the hidden semantics and simultaneously respects the intrinsic geometric structure. In GNMF, an affinity graph is constructed from the original data space to encode the geometrical information. In this paper, we propose a novel idea which engages a Multiple Kernel Learning approach into refining the graph structure that reflects the factorization of the matrix and the new data space. The GrNMF is improved by utilizing the graph refined by the kernel learning, and then a novel kernel learning method is introduced under the GrNMF framework. Our approach shows encouraging results of the proposed algorithm in comparison to the state-of-the-art clustering algorithms like NMF, GrNMF, SVD etc.

The determination of beam quality correction factors: Monte Carlo simulations and measurements.

Science.gov (United States)

González-Castaño, D M; Hartmann, G H; Sánchez-Doblado, F; Gómez, F; Kapsch, R-P; Pena, J; Capote, R

2009-08-07

Modern dosimetry protocols are based on the use of ionization chambers provided with a calibration factor in terms of absorbed dose to water. The basic formula to determine the absorbed dose at a user's beam contains the well-known beam quality correction factor that is required whenever the quality of radiation used at calibration differs from that of the user's radiation. The dosimetry protocols describe the whole ionization chamber calibration procedure and include tabulated beam quality correction factors which refer to 60Co gamma radiation used as calibration quality. They have been calculated for a series of ionization chambers and radiation qualities based on formulae, which are also described in the protocols. In the case of high-energy photon beams, the relative standard uncertainty of the beam quality correction factor is estimated to amount to 1%. In the present work, two alternative methods to determine beam quality correction factors are prescribed-Monte Carlo simulation using the EGSnrc system and an experimental method based on a comparison with a reference chamber. Both Monte Carlo calculations and ratio measurements were carried out for nine chambers at several radiation beams. Four chamber types are not included in the current dosimetry protocols. Beam quality corrections for the reference chamber at two beam qualities were also measured using a calorimeter at a PTB Primary Standards Dosimetry Laboratory. Good agreement between the Monte Carlo calculated (1% uncertainty) and measured (0.5% uncertainty) beam quality correction factors was obtained. Based on these results we propose that beam quality correction factors can be generated both by measurements and by the Monte Carlo simulations with an uncertainty at least comparable to that given in current dosimetry protocols.

Implicit vs. Explicit Trust in Social Matrix Factorization

NARCIS (Netherlands)

Fazeli, Soude; Loni, Babak; Bellogin, Alejandro; Drachsler, Hendrik; Sloep, Peter

2014-01-01

Incorporating social trust in Matrix Factorization (MF) methods demonstrably improves accuracy of rating prediction. Such approaches mainly use the trust scores explicitly expressed by users. However, it is often challenging to have users provide explicit trust scores of each other. There exist

How to get the Matrix Organization to Work

DEFF Research Database (Denmark)

Burton, Richard M.; Obel, Børge; Håkonsson, Dorthe Døjbak

2015-01-01

a matrix to work, taking a multi-contingency perspective. We translate the matrix concept for designers and managers who are considering a matrix organization and argue that three factors are critical for its success: (1) Strong purpose: Only choose the matrix structure if there are strong reasons...... for doing so, (2) Alignment among contingencies: A matrix can only be successful if key contingencies are aligned with the matrix’s purpose, and (3) Management of junctions: The success of a matrix depends on how well activities at the junctions of the matrix are managed....

Scattering amplitudes and static atomic correction factors for the composition-sensitive 002 reflection in sphalerite ternary III-V and II-VI semiconductors.

Science.gov (United States)

Schowalter, M; Müller, K; Rosenauer, A

2012-01-01

Modified atomic scattering amplitudes (MASAs), taking into account the redistribution of charge due to bonds, and the respective correction factors considering the effect of static atomic displacements were computed for the chemically sensitive 002 reflection for ternary III-V and II-VI semiconductors. MASAs were derived from computations within the density functional theory formalism. Binary eight-atom unit cells were strained according to each strain state s (thin, intermediate, thick and fully relaxed electron microscopic specimen) and each concentration (x = 0, …, 1 in 0.01 steps), where the lattice parameters for composition x in strain state s were calculated using continuum elasticity theory. The concentration dependence was derived by computing MASAs for each of these binary cells. Correction factors for static atomic displacements were computed from relaxed atom positions by generating 50 × 50 × 50 supercells using the lattice parameter of the eight-atom unit cells. Atoms were randomly distributed according to the required composition. Polynomials were fitted to the composition dependence of the MASAs and the correction factors for the different strain states. Fit parameters are given in the paper.

Decay of autoionizing states in time-dependent density functional and reduced density matrix functional theory

Energy Technology Data Exchange (ETDEWEB)

Kapoor, Varun; Brics, Martins; Bauer, Dieter [Institut fuer Physik, Universitaet Rostock, 18051 Rostock (Germany)

2013-07-01

Autoionizing states are inaccessible to time-dependent density functional theory (TDDFT) using known, adiabatic Kohn-Sham (KS) potentials. We determine the exact KS potential for a numerically exactly solvable model Helium atom interacting with a laser field that is populating an autoionizing state. The exact single-particle density of the population in the autoionizing state corresponds to that of the energetically lowest quasi-stationary state in the exact KS potential. We describe how this exact potential controls the decay by a barrier whose height and width allows for the density to tunnel out and decay with the same rate as in the ab initio time-dependent Schroedinger calculation. However, devising a useful exchange-correlation potential that is capable of governing such a scenario in general and in more complex systems is hopeless. As an improvement over TDDFT, time-dependent reduced density matrix functional theory has been proposed. We are able to obtain for the above described autoionization process the exact time-dependent natural orbitals (i.e., the eigenfunctions of the exact, time-dependent one-body reduced density matrix) and study the potentials that appear in the equations of motion for the natural orbitals and the structure of the two-body density matrix expanded in them.

Personality Assessment Inventory scale characteristics and factor structure in the assessment of alcohol dependency.

Science.gov (United States)

Schinka, J A

1995-02-01

Individual scale characteristics and the inventory structure of the Personality Assessment Inventory (PAI; Morey, 1991) were examined by conducting internal consistency and factor analyses of item and scale score data from a large group (N = 301) of alcohol-dependent patients. Alpha coefficients, mean inter-item correlations, and corrected item-total scale correlations for the sample paralleled values reported by Morey for a large clinical sample. Minor differences in the scale factor structure of the inventory from Morey's clinical sample were found. Overall, the findings support the use of the PAI in the assessment of personality and psychopathology of alcohol-dependent patients.

Efficiency criterion for teleportation via channel matrix, measurement matrix and collapsed matrix

Directory of Open Access Journals (Sweden)

Xin-Wei Zha

Full Text Available In this paper, three kinds of coefficient matrixes (channel matrix, measurement matrix, collapsed matrix associated with the pure state for teleportation are presented, the general relation among channel matrix, measurement matrix and collapsed matrix is obtained. In addition, a criterion for judging whether a state can be teleported successfully is given, depending on the relation between the number of parameter of an unknown state and the rank of the collapsed matrix. Keywords: Channel matrix, Measurement matrix, Collapsed matrix, Teleportation

Higher order spin-dependent terms in D0-brane scattering from the matrix model

International Nuclear Information System (INIS)

McArthur, I.N.

1998-01-01

The potential describing long-range interactions between D0-branes contains spin-dependent terms. In the matrix model, these should be reproduced by the one-loop effective action computed in the presence of a non-trivial fermionic background ψ. The v 3 ψ 2 /r 8 term in the effective action has been computed by Kraus and shown to correspond to a spin-orbit interaction between D0-branes, and the ψ 8 /r 11 term in the static potential has been obtained by Barrio et al. In this paper, the v 2 ψ 4 /r 9 term is computing in the matrix model and compared with the corresponding results of Morales et al. obtained using string theoretic methods. The technique employed is adapted to the underlying supersymmetry of the matrix model, and should be useful in the calculation of spin-dependent effects in more general Dp-brane scatterings. (orig.)

Integrating temperature-dependent life table data into a matrix projection model for Drosophila suzukii population estimation.

Directory of Open Access Journals (Sweden)

Nik G Wiman

Full Text Available Temperature-dependent fecundity and survival data was integrated into a matrix population model to describe relative Drosophila suzukii Matsumura (Diptera: Drosophilidae population increase and age structure based on environmental conditions. This novel modification of the classic Leslie matrix population model is presented as a way to examine how insect populations interact with the environment, and has application as a predictor of population density. For D. suzukii, we examined model implications for pest pressure on crops. As case studies, we examined model predictions in three small fruit production regions in the United States (US and one in Italy. These production regions have distinctly different climates. In general, patterns of adult D. suzukii trap activity broadly mimicked seasonal population levels predicted by the model using only temperature data. Age structure of estimated populations suggest that trap and fruit infestation data are of limited value and are insufficient for model validation. Thus, we suggest alternative experiments for validation. The model is advantageous in that it provides stage-specific population estimation, which can potentially guide management strategies and provide unique opportunities to simulate stage-specific management effects such as insecticide applications or the effect of biological control on a specific life-stage. The two factors that drive initiation of the model are suitable temperatures (biofix and availability of a suitable host medium (fruit. Although there are many factors affecting population dynamics of D. suzukii in the field, temperature-dependent survival and reproduction are believed to be the main drivers for D. suzukii populations.

Strong factor in the SO(2,3) S matrix

International Nuclear Information System (INIS)

Amado, R.D.; Sparrow, D.A.

1986-01-01

The group theoretic S matrix of Alhassid, Iachello, and Wu is factorable into a product of Coulomb and strong factors. The strong factor is examined with a view to relating it to more fa- miliar potential and phase shift descriptions. We find simple approximate expressions for the phase shifts which are very accurate for heavy-ion-type applications. For peripheral scattering it is possible to obtain simple expressions relating the strong factor to an effective potential

Two-particle one-hole multiple-scattering contribution to 17O energies using an energy-dependent reaction matrix

International Nuclear Information System (INIS)

Bando, H.; Krenciglowa, E.M.

1976-01-01

The role of 2p1h correlations in 17 O is studied within a multiple-scattering formalism. An accurate, energy-dependent reaction matrix with orthogonalized plane-wave intermediate states is used to assess the relative importance of particle-particle and particle-hole correlations in the 17 O energies. The effect of energy dependence of the reaction matrix is closely examined. (Auth.)

Hamiltonian formalism, quantization and S matrix for supergravity. [S matrix, canonical constraints

Energy Technology Data Exchange (ETDEWEB)

Fradkin, E S; Vasiliev, M A [AN SSSR, Moscow. Fizicheskij Inst.

1977-12-05

The canonical formalism for supergravity is constructed. The algebra of canonical constraints is found. The correct expression for the S matrix is obtained. Usual 'covariant methods' lead to an incorrect S matrix in supergravity since a new four-particle interaction of ghostfields survives in the Lagrangian expression of the S matrix.

Membrane-type-3 matrix metalloproteinase (MT3-MMP functions as a matrix composition-dependent effector of melanoma cell invasion.

Directory of Open Access Journals (Sweden)

Olga Tatti

Full Text Available In primary human melanoma, the membrane-type matrix metalloproteinase, MT3-MMP, is overexpressed in the most aggressive nodular-type tumors. Unlike MT1-MMP and MT2-MMP, which promote cell invasion through basement membranes and collagen type I-rich tissues, the function of MT3-MMP in tumor progression remains unclear. Here, we demonstrate that MT3-MMP inhibits MT1-MMP-driven melanoma cell invasion in three-dimensional collagen, while yielding an altered, yet MT1-MMP-dependent, form of expansive growth behavior that phenocopies the formation of nodular cell colonies. In melanoma cell lines originating from advanced primary or metastatic lesions, endogenous MT3-MMP expression was associated with limited collagen-invasive potential. In the cell lines with highest MT3-MMP expression relative to MT1-MMP, collagen-invasive activity was increased following stable MT3-MMP gene silencing. Consistently, MT3-MMP overexpression in cells derived from less advanced superficially spreading melanoma lesions, or in the MT3-MMP knockdown cells, reduced MT1-MMP-dependent collagen invasion. Rather than altering MT1-MMP transcription, MT3-MMP interacted with MT1-MMP in membrane complexes and reduced its cell surface expression. By contrast, as a potent fibrinolytic enzyme, MT3-MMP induced efficient invasion of the cells in fibrin, a provisional matrix component frequently found at tumor-host tissue interfaces and perivascular spaces of melanoma. Since MT3-MMP was significantly upregulated in biopsies of human melanoma metastases, these results identify MT3-MMP as a matrix-dependent modifier of the invasive tumor cell functions during melanoma progression.

Influence factors and corrections of low-energy γ-ray penetration in ash analysis

International Nuclear Information System (INIS)

Cheng Bo; Tuo Xianguo; Zhou Jianbin; Tong Yunfu

2002-01-01

The author introduces the system of the coal ash analyzer. This system is based on the low-energy γ-ray source 241 Am emitted two kinds of energy peaks 26.4 keV and 59.6 keV to analyze the ash in coal with the penetration way. The author also offers the factors to influence the accuracy of ash analysis, such as the size of coal, the environmental temperature, the important elements in coal, and water in coal too. At the same time, depending on the cause of the factors, it offer some methods of correction such as the way of the auto-hold energy peak, the way of the auto-compensation way, and so on. The author also mentions the other influence factors of the measurement accuracy to be noticed during the experiment. All these aim at clearing off the influence factors of measurement accuracy through the experiments

A pseudospectral matrix method for time-dependent tensor fields on a spherical shell

International Nuclear Information System (INIS)

Brügmann, Bernd

2013-01-01

We construct a pseudospectral method for the solution of time-dependent, non-linear partial differential equations on a three-dimensional spherical shell. The problem we address is the treatment of tensor fields on the sphere. As a test case we consider the evolution of a single black hole in numerical general relativity. A natural strategy would be the expansion in tensor spherical harmonics in spherical coordinates. Instead, we consider the simpler and potentially more efficient possibility of a double Fourier expansion on the sphere for tensors in Cartesian coordinates. As usual for the double Fourier method, we employ a filter to address time-step limitations and certain stability issues. We find that a tensor filter based on spin-weighted spherical harmonics is successful, while two simplified, non-spin-weighted filters do not lead to stable evolutions. The derivatives and the filter are implemented by matrix multiplication for efficiency. A key technical point is the construction of a matrix multiplication method for the spin-weighted spherical harmonic filter. As example for the efficient parallelization of the double Fourier, spin-weighted filter method we discuss an implementation on a GPU, which achieves a speed-up of up to a factor of 20 compared to a single core CPU implementation

Energy-dependent applications of the transfer matrix method

International Nuclear Information System (INIS)

Oeztunali, O.I.; Aronson, R.

1975-01-01

The transfer matrix method is applied to energy-dependent neutron transport problems for multiplying and nonmultiplying media in one-dimensional plane geometry. Experimental cross sections are used for total, elastic, and inelastic scattering and fission. Numerical solutions are presented for the problem of a unit point isotropic source in an infinite medium of water and for the problem of the critical 235 U slab with finite water reflectors. No iterations were necessary in this method. Numerical results obtained are consistent with physical considerations and compare favorably with the moments method results for the problem of the unit point isotropic source in an infinite water medium. (U.S.)

Neutrophil-Derived MMP-8 Drives AMPK-Dependent Matrix Destruction in Human Pulmonary Tuberculosis

Science.gov (United States)

Ong, Catherine W. M.; Elkington, Paul T.; Brilha, Sara; Ugarte-Gil, Cesar; Tome-Esteban, Maite T.; Tezera, Liku B.; Pabisiak, Przemyslaw J.; Moores, Rachel C.; Sathyamoorthy, Tarangini; Patel, Vimal; Gilman, Robert H.; Porter, Joanna C.; Friedland, Jon S.

2015-01-01

Pulmonary cavities, the hallmark of tuberculosis (TB), are characterized by high mycobacterial load and perpetuate the spread of M. tuberculosis. The mechanism of matrix destruction resulting in cavitation is not well defined. Neutrophils are emerging as key mediators of TB immunopathology and their influx are associated with poor outcomes. We investigated neutrophil-dependent mechanisms involved in TB-associated matrix destruction using a cellular model, a cohort of 108 patients, and in separate patient lung biopsies. Neutrophil-derived NF-kB-dependent matrix metalloproteinase-8 (MMP-8) secretion was up-regulated in TB and caused matrix destruction both in vitro and in respiratory samples of TB patients. Collagen destruction induced by TB infection was abolished by doxycycline, a licensed MMP inhibitor. Neutrophil extracellular traps (NETs) contain MMP-8 and are increased in samples from TB patients. Neutrophils lined the circumference of human pulmonary TB cavities and sputum MMP-8 concentrations reflected TB radiological and clinical disease severity. AMPK, a central regulator of catabolism, drove neutrophil MMP-8 secretion and neutrophils from AMPK-deficient patients secrete lower MMP-8 concentrations. AMPK-expressing neutrophils are present in human TB lung biopsies with phospho-AMPK detected in nuclei. These data demonstrate that neutrophil-derived MMP-8 has a key role in the immunopathology of TB and is a potential target for host-directed therapy in this infectious disease. PMID:25996154

Neutrophil-Derived MMP-8 Drives AMPK-Dependent Matrix Destruction in Human Pulmonary Tuberculosis.

Science.gov (United States)

Ong, Catherine W M; Elkington, Paul T; Brilha, Sara; Ugarte-Gil, Cesar; Tome-Esteban, Maite T; Tezera, Liku B; Pabisiak, Przemyslaw J; Moores, Rachel C; Sathyamoorthy, Tarangini; Patel, Vimal; Gilman, Robert H; Porter, Joanna C; Friedland, Jon S

2015-05-01

Pulmonary cavities, the hallmark of tuberculosis (TB), are characterized by high mycobacterial load and perpetuate the spread of M. tuberculosis. The mechanism of matrix destruction resulting in cavitation is not well defined. Neutrophils are emerging as key mediators of TB immunopathology and their influx are associated with poor outcomes. We investigated neutrophil-dependent mechanisms involved in TB-associated matrix destruction using a cellular model, a cohort of 108 patients, and in separate patient lung biopsies. Neutrophil-derived NF-kB-dependent matrix metalloproteinase-8 (MMP-8) secretion was up-regulated in TB and caused matrix destruction both in vitro and in respiratory samples of TB patients. Collagen destruction induced by TB infection was abolished by doxycycline, a licensed MMP inhibitor. Neutrophil extracellular traps (NETs) contain MMP-8 and are increased in samples from TB patients. Neutrophils lined the circumference of human pulmonary TB cavities and sputum MMP-8 concentrations reflected TB radiological and clinical disease severity. AMPK, a central regulator of catabolism, drove neutrophil MMP-8 secretion and neutrophils from AMPK-deficient patients secrete lower MMP-8 concentrations. AMPK-expressing neutrophils are present in human TB lung biopsies with phospho-AMPK detected in nuclei. These data demonstrate that neutrophil-derived MMP-8 has a key role in the immunopathology of TB and is a potential target for host-directed therapy in this infectious disease.

Strange mesonic transition form factor in the chiral constituent quark model

International Nuclear Information System (INIS)

Ito, H.; Ramsey-Musolf, M.J.

1998-01-01

The form factor g ρπ (S) (Q 2 ) of the strange vector current transition matrix element left-angle ρ|bar sγ μ s|π right-angle is calculated within the chiral quark model. A strange vector current of the constituent U and D quarks is induced by kaon radiative corrections and this mechanism yields the nonvanishing values of g ρπ (S) (0). The numerical result at the photon point is consistent with the one given by the φ-meson dominance model, but the falloff in the Q 2 dependence is faster than the monopole form factor. Mesonic radiative corrections are also examined for the electromagnetic ρ-to-π and K * -to-K transition amplitudes. copyright 1998 The American Physical Society

Theoretical determination of gamma spectrometry systems efficiency based on probability functions. Application to self-attenuation correction factors

Energy Technology Data Exchange (ETDEWEB)

Barrera, Manuel, E-mail: manuel.barrera@uca.es [Escuela Superior de Ingeniería, University of Cadiz, Avda, Universidad de Cadiz 10, 11519 Puerto Real, Cadiz (Spain); Suarez-Llorens, Alfonso [Facultad de Ciencias, University of Cadiz, Avda, Rep. Saharaui s/n, 11510 Puerto Real, Cadiz (Spain); Casas-Ruiz, Melquiades; Alonso, José J.; Vidal, Juan [CEIMAR, University of Cadiz, Avda, Rep. Saharaui s/n, 11510 Puerto Real, Cádiz (Spain)

2017-05-11

A generic theoretical methodology for the calculation of the efficiency of gamma spectrometry systems is introduced in this work. The procedure is valid for any type of source and detector and can be applied to determine the full energy peak and the total efficiency of any source-detector system. The methodology is based on the idea of underlying probability of detection, which describes the physical model for the detection of the gamma radiation at the particular studied situation. This probability depends explicitly on the direction of the gamma radiation, allowing the use of this dependence the development of more realistic and complex models than the traditional models based on the point source integration. The probability function that has to be employed in practice must reproduce the relevant characteristics of the detection process occurring at the particular studied situation. Once the probability is defined, the efficiency calculations can be performed in general by using numerical methods. Monte Carlo integration procedure is especially useful to perform the calculations when complex probability functions are used. The methodology can be used for the direct determination of the efficiency and also for the calculation of corrections that require this determination of the efficiency, as it is the case of coincidence summing, geometric or self-attenuation corrections. In particular, we have applied the procedure to obtain some of the classical self-attenuation correction factors usually employed to correct for the sample attenuation of cylindrical geometry sources. The methodology clarifies the theoretical basis and approximations associated to each factor, by making explicit the probability which is generally hidden and implicit to each model. It has been shown that most of these self-attenuation correction factors can be derived by using a common underlying probability, having this probability a growing level of complexity as it reproduces more precisely

Fluence correction factors for graphite calorimetry in a low-energy clinical proton beam: I. Analytical and Monte Carlo simulations.

Science.gov (United States)

Palmans, H; Al-Sulaiti, L; Andreo, P; Shipley, D; Lühr, A; Bassler, N; Martinkovič, J; Dobrovodský, J; Rossomme, S; Thomas, R A S; Kacperek, A

2013-05-21

The conversion of absorbed dose-to-graphite in a graphite phantom to absorbed dose-to-water in a water phantom is performed by water to graphite stopping power ratios. If, however, the charged particle fluence is not equal at equivalent depths in graphite and water, a fluence correction factor, kfl, is required as well. This is particularly relevant to the derivation of absorbed dose-to-water, the quantity of interest in radiotherapy, from a measurement of absorbed dose-to-graphite obtained with a graphite calorimeter. In this work, fluence correction factors for the conversion from dose-to-graphite in a graphite phantom to dose-to-water in a water phantom for 60 MeV mono-energetic protons were calculated using an analytical model and five different Monte Carlo codes (Geant4, FLUKA, MCNPX, SHIELD-HIT and McPTRAN.MEDIA). In general the fluence correction factors are found to be close to unity and the analytical and Monte Carlo codes give consistent values when considering the differences in secondary particle transport. When considering only protons the fluence correction factors are unity at the surface and increase with depth by 0.5% to 1.5% depending on the code. When the fluence of all charged particles is considered, the fluence correction factor is about 0.5% lower than unity at shallow depths predominantly due to the contributions from alpha particles and increases to values above unity near the Bragg peak. Fluence correction factors directly derived from the fluence distributions differential in energy at equivalent depths in water and graphite can be described by kfl = 0.9964 + 0.0024·zw-eq with a relative standard uncertainty of 0.2%. Fluence correction factors derived from a ratio of calculated doses at equivalent depths in water and graphite can be described by kfl = 0.9947 + 0.0024·zw-eq with a relative standard uncertainty of 0.3%. These results are of direct relevance to graphite calorimetry in low-energy protons but given that the fluence

Investigation of electron-loss and photon scattering correction factors for FAC-IR-300 ionization chamber

Science.gov (United States)

Mohammadi, S. M.; Tavakoli-Anbaran, H.; Zeinali, H. Z.

2017-02-01

The parallel-plate free-air ionization chamber termed FAC-IR-300 was designed at the Atomic Energy Organization of Iran, AEOI. This chamber is used for low and medium X-ray dosimetry on the primary standard level. In order to evaluate the air-kerma, some correction factors such as electron-loss correction factor (ke) and photon scattering correction factor (ksc) are needed. ke factor corrects the charge loss from the collecting volume and ksc factor corrects the scattering of photons into collecting volume. In this work ke and ksc were estimated by Monte Carlo simulation. These correction factors are calculated for mono-energy photon. As a result of the simulation data, the ke and ksc values for FAC-IR-300 ionization chamber are 1.0704 and 0.9982, respectively.

Analytic representation of the backscatter correction factor at the exit of high energy photon beams

International Nuclear Information System (INIS)

Kappas, K.; Rosenwald, J.C.

1991-01-01

In high-energy X-ray beams, the dose calculated near the exit surface under electronic equilibrium conditions is generally over-estimated since it is derived from measurements performed in water with large thickness of backscattering material. The resulting error depends on a number of parameters such as beam energy, field dimension, thickness of overlying and underlying material. The authors have systematically measured for 4 different energies and for different para- meters and for different combinations of the above parameters, the reduction of dose due to backscatter. This correction is expressed as a multiplicative factor, called 'Backscatter Correction Factor' (BCF). This BCF is larger for lower energies, larger field sizes and larger depths. The BCF has been represented by an analytical expression which involves an exponential function of the backscattering thickness and linear relationships with depth field size and beam quality index. Using this expression, the BCF can be calculated within 0.5% for any conditions in the energy range investigated. (author). 14 refs.; 4 figs.; 3 tabs

Correction factors for assessing immersion suits under harsh conditions.

Science.gov (United States)

Power, Jonathan; Tikuisis, Peter; Ré, António Simões; Barwood, Martin; Tipton, Michael

2016-03-01

Many immersion suit standards require testing of thermal protective properties in calm, circulating water while these suits are typically used in harsher environments where they often underperform. Yet it can be expensive and logistically challenging to test immersion suits in realistic conditions. The goal of this work was to develop a set of correction factors that would allow suits to be tested in calm water yet ensure they will offer sufficient protection in harsher conditions. Two immersion studies, one dry and the other with 500 mL of water within the suit, were conducted in wind and waves to measure the change in suit insulation. In both studies, wind and waves resulted in a significantly lower immersed insulation value compared to calm water. The minimum required thermal insulation for maintaining heat balance can be calculated for a given mean skin temperature, metabolic heat production, and water temperature. Combining the physiological limits of sustainable cold water immersion and actual suit insulation, correction factors can be deduced for harsh conditions compared to calm. The minimum in-situ suit insulation to maintain thermal balance is 1.553-0.0624·TW + 0.00018·TW(2) for a dry calm condition. Multiplicative correction factors to the above equation are 1.37, 1.25, and 1.72 for wind + waves, 500 mL suit wetness, and both combined, respectively. Calm water certification tests of suit insulation should meet or exceed the minimum in-situ requirements to maintain thermal balance, and correction factors should be applied for a more realistic determination of minimum insulation for harsh conditions. Crown Copyright © 2015. Published by Elsevier Ltd. All rights reserved.

Leaked filters for energetic and angular dependence corrections of thermoluminescent response

International Nuclear Information System (INIS)

Manzoli, Jose Eduardo; Shammas, Gabriel Issa Jabra; Campos, Vicente de Paulo de

2007-01-01

Many thermoluminescent materials has been developed and used for photon personal dosimetry but no one has all desired characteristics alone. These characteristics include robustness, high sensitivity, energy photon independence, large range of photon energy detection, good reproducibility and small fading. The phosphors advantages begin to be more required and its disadvantages have became more apparent, in a global market more and more competitive. Calcium Sulfate Dysprosium doped (CaSO 4 :Dy) and Calcium Fluoride Manganese doped (CaF 2 :Mn) phosphor Thermoluminescent Dosimeters (TLDs) have been used by many laboratories. They are used in environmental and area monitoring, once they present more sensibility than other phosphors, like LiF:Mg. Theirs main disadvantage is the strong energetic dependence response, which must be corrected for theirs application in routine, where the kind of photon radiation is unknown a priori. An interesting way to make this correction is to interject a leaked filter between the beam and the phosphor, where the beam could strike the phosphor at any angle. In order to reduce the energetic dependence on any incidence angle, this work presents experimental and simulation studies on some filter geometries. It was made TL readings and simulations on TL responses to photon irradiations with gamma rays of 60 Co and X-rays of 33; 48 and 118 keV, on many incidence angles from zero to ninety degrees. The results pointed out the best filter thicknesses and widths, in order to optimize the correction of energetic dependence for the studied geometries. (author)

Non-negative matrix factorization in texture feature for classification of dementia with MRI data

Science.gov (United States)

Sarwinda, D.; Bustamam, A.; Ardaneswari, G.

2017-07-01

This paper investigates applications of non-negative matrix factorization as feature selection method to select the features from gray level co-occurrence matrix. The proposed approach is used to classify dementia using MRI data. In this study, texture analysis using gray level co-occurrence matrix is done to feature extraction. In the feature extraction process of MRI data, we found seven features from gray level co-occurrence matrix. Non-negative matrix factorization selected three features that influence of all features produced by feature extractions. A Naïve Bayes classifier is adapted to classify dementia, i.e. Alzheimer's disease, Mild Cognitive Impairment (MCI) and normal control. The experimental results show that non-negative factorization as feature selection method able to achieve an accuracy of 96.4% for classification of Alzheimer's and normal control. The proposed method also compared with other features selection methods i.e. Principal Component Analysis (PCA).

Attenuation correction factors for cylindrical, disc and box geometry

International Nuclear Information System (INIS)

Agarwal, Chhavi; Poi, Sanhita; Mhatre, Amol; Goswami, A.; Gathibandhe, M.

2009-01-01

In the present study, attenuation correction factors have been experimentally determined for samples having cylindrical, disc and box geometry and compared with the attenuation correction factors calculated by Hybrid Monte Carlo (HMC) method [ C. Agarwal, S. Poi, A. Goswami, M. Gathibandhe, R.A. Agrawal, Nucl. Instr. and. Meth. A 597 (2008) 198] and with the near-field and far-field formulations available in literature. It has been observed that the near-field formulae, although said to be applicable at close sample-detector geometry, does not work at very close sample-detector configuration. The advantage of the HMC method is that it is found to be valid for all sample-detector geometries.

Constructing the tree-level Yang-Mills S-matrix using complex factorization

Science.gov (United States)

Schuster, Philip C.; Toro, Natalia

2009-06-01

A remarkable connection between BCFW recursion relations and constraints on the S-matrix was made by Benincasa and Cachazo in 0705.4305, who noted that mutual consistency of different BCFW constructions of four-particle amplitudes generates non-trivial (but familiar) constraints on three-particle coupling constants — these include gauge invariance, the equivalence principle, and the lack of non-trivial couplings for spins > 2. These constraints can also be derived with weaker assumptions, by demanding the existence of four-point amplitudes that factorize properly in all unitarity limits with complex momenta. From this starting point, we show that the BCFW prescription can be interpreted as an algorithm for fully constructing a tree-level S-matrix, and that complex factorization of general BCFW amplitudes follows from the factorization of four-particle amplitudes. The allowed set of BCFW deformations is identified, formulated entirely as a statement on the three-particle sector, and using only complex factorization as a guide. Consequently, our analysis based on the physical consistency of the S-matrix is entirely independent of field theory. We analyze the case of pure Yang-Mills, and outline a proof for gravity. For Yang-Mills, we also show that the well-known scaling behavior of BCFW-deformed amplitudes at large z is a simple consequence of factorization. For gravity, factorization in certain channels requires asymptotic behavior ~ 1/z2.

Constructing the tree-level Yang-Mills S-matrix using complex factorization

International Nuclear Information System (INIS)

Schuster, Philip C.; Toro, Natalia

2009-01-01

A remarkable connection between BCFW recursion relations and constraints on the S-matrix was made by Benincasa and Cachazo in 0705.4305, who noted that mutual consistency of different BCFW constructions of four-particle amplitudes generates non-trivial (but familiar) constraints on three-particle coupling constants - these include gauge invariance, the equivalence principle, and the lack of non-trivial couplings for spins > 2. These constraints can also be derived with weaker assumptions, by demanding the existence of four-point amplitudes that factorize properly in all unitarity limits with complex momenta. From this starting point, we show that the BCFW prescription can be interpreted as an algorithm for fully constructing a tree-level S-matrix, and that complex factorization of general BCFW amplitudes follows from the factorization of four-particle amplitudes. The allowed set of BCFW deformations is identified, formulated entirely as a statement on the three-particle sector, and using only complex factorization as a guide. Consequently, our analysis based on the physical consistency of the S-matrix is entirely independent of field theory. We analyze the case of pure Yang-Mills, and outline a proof for gravity. For Yang-Mills, we also show that the well-known scaling behavior of BCFW-deformed amplitudes at large z is a simple consequence of factorization. For gravity, factorization in certain channels requires asymptotic behavior ∼ 1/z 2 .

On the ambiguities in the tri-bimaximal mixing matrix and corresponding charged lepton corrections

International Nuclear Information System (INIS)

Duarah, Chandan; Nimai Singh, N

2013-01-01

Two negative signs naturally appear in the U μ1 and U τ2 elements of the tri-bimaximal (TBM) matrix for positive values of the mixing angles θ 12 and θ 23 . Apart from this, in other TBM matrices negative signs are shifted to other elements in each case. They account for positive as well as negative values of θ 12 and θ 23 . We discuss the sign ambiguity in the TBM matrix and find that the TBM matrices, in fact, can be divided into two groups under certain circumstances. Interestingly, this classification of the TBM matrices is accompanied by two different μ − τ symmetric mass matrices which can separately be related to the groups. To accommodate the non-zero value of θ 13 and deviate θ 23 toward the first octant, we then perturb the TBM mixing ansatz with the help of charged lepton correction. The diagonalizing matrices for the charged lepton mass matrices also possess sign ambiguity and respect the grouping of the TBM matrices. They are parameterized in terms of the Wolfenstein parameter λ and satisfy the unitarity condition up to the second order in λ. (paper)

Investigation of electron-loss and photon scattering correction factors for FAC-IR-300 ionization chamber

International Nuclear Information System (INIS)

Mohammadi, S.M.; Tavakoli-Anbaran, H.; Zeinali, H.Z.

2017-01-01

The parallel-plate free-air ionization chamber termed FAC-IR-300 was designed at the Atomic Energy Organization of Iran, AEOI. This chamber is used for low and medium X-ray dosimetry on the primary standard level. In order to evaluate the air-kerma, some correction factors such as electron-loss correction factor (k e ) and photon scattering correction factor (k sc ) are needed. k e factor corrects the charge loss from the collecting volume and k sc factor corrects the scattering of photons into collecting volume. In this work k e and k sc were estimated by Monte Carlo simulation. These correction factors are calculated for mono-energy photon. As a result of the simulation data, the k e and k sc values for FAC-IR-300 ionization chamber are 1.0704 and 0.9982, respectively.

Methods of orbit correction system optimization

International Nuclear Information System (INIS)

Chao, Yu-Chiu.

1997-01-01

Extracting optimal performance out of an orbit correction system is an important component of accelerator design and evaluation. The question of effectiveness vs. economy, however, is not always easily tractable. This is especially true in cases where betatron function magnitude and phase advance do not have smooth or periodic dependencies on the physical distance. In this report a program is presented using linear algebraic techniques to address this problem. A systematic recipe is given, supported with quantitative criteria, for arriving at an orbit correction system design with the optimal balance between performance and economy. The orbit referred to in this context can be generalized to include angle, path length, orbit effects on the optical transfer matrix, and simultaneous effects on multiple pass orbits

Power factor correction (PFC) converters feeding brushless DC ...

African Journals Online (AJOL)

DR OKE

1Department of Electrical Engineering, Indian Institute of Technology Delhi, INDIA ... Hence, power factor correction (PFC) converters are used for achieving a unity ...... He is currently working as a Systems Engineer (Power IC) in AvantGarde ...

Canonical polyadic decomposition of third-order semi-nonnegative semi-symmetric tensors using LU and QR matrix factorizations

Science.gov (United States)

Wang, Lu; Albera, Laurent; Kachenoura, Amar; Shu, Huazhong; Senhadji, Lotfi

2014-12-01

Semi-symmetric three-way arrays are essential tools in blind source separation (BSS) particularly in independent component analysis (ICA). These arrays can be built by resorting to higher order statistics of the data. The canonical polyadic (CP) decomposition of such semi-symmetric three-way arrays allows us to identify the so-called mixing matrix, which contains the information about the intensities of some latent source signals present in the observation channels. In addition, in many applications, such as the magnetic resonance spectroscopy (MRS), the columns of the mixing matrix are viewed as relative concentrations of the spectra of the chemical components. Therefore, the two loading matrices of the three-way array, which are equal to the mixing matrix, are nonnegative. Most existing CP algorithms handle the symmetry and the nonnegativity separately. Up to now, very few of them consider both the semi-nonnegativity and the semi-symmetry structure of the three-way array. Nevertheless, like all the methods based on line search, trust region strategies, and alternating optimization, they appear to be dependent on initialization, requiring in practice a multi-initialization procedure. In order to overcome this drawback, we propose two new methods, called [InlineEquation not available: see fulltext.] and [InlineEquation not available: see fulltext.], to solve the problem of CP decomposition of semi-nonnegative semi-symmetric three-way arrays. Firstly, we rewrite the constrained optimization problem as an unconstrained one. In fact, the nonnegativity constraint of the two symmetric modes is ensured by means of a square change of variable. Secondly, a Jacobi-like optimization procedure is adopted because of its good convergence property. More precisely, the two new methods use LU and QR matrix factorizations, respectively, which consist in formulating high-dimensional optimization problems into several sequential polynomial and rational subproblems. By using both LU

Electron fluence correction factors for various materials in clinical electron beams

International Nuclear Information System (INIS)

Olivares, M.; Blois, F. de; Podgorsak, E.B.; Seuntjens, J.P.

2001-01-01

correction factors for open electron beams are approximately proportional to the electron density of the phantom material and only weakly dependent on electron beam energy

Data fusion in metabolomics using coupled matrix and tensor factorizations

DEFF Research Database (Denmark)

Evrim, Acar Ataman; Bro, Rasmus; Smilde, Age Klaas

2015-01-01

of heterogeneous (i.e., in the form of higher order tensors and matrices) data sets with shared/unshared factors. In order to jointly analyze such heterogeneous data sets, we formulate data fusion as a coupled matrix and tensor factorization (CMTF) problem, which has already proved useful in many data mining...

On the Interpretation of Gravitational Corrections to Gauge Couplings

CERN Document Server

Ellis, John

2012-01-01

Several recent papers discuss gravitational corrections to gauge couplings that depend quadratically on the energy. In the framework of the background-field approach, these correspond in general to adding to the effective action terms quadratic in the field strength but with higher-order space-time derivatives. We observe that such terms can be removed by appropriate local field redefinitions, and do not contribute to physical scattering-matrix elements. We illustrate this observation in the context of open string theory, where the effective action includes, among other terms, the well-known Born-Infeld form of non-linear electrodynamics. We conclude that the quadratically energy-dependent gravitational corrections are \\emph{not} physical in the sense of contributing to the running of a physically-measurable gauge coupling, or of unifying couplings as in string theory.

A simple method for correcting the neutron self-shielding effect of matrix and improving the analytical response in prompt gamma-ray neutron activation analysis

International Nuclear Information System (INIS)

Sudarshan, K.; Tripathi, R.; Nair, A.G.C.; Acharya, R.; Reddy, A.V.R.; Goswami, A.

2005-01-01

A simple method using an internal standard is proposed to correct for the self-shielding effect of B, Cd and Gd in a matrix. This would increase the linear dynamic range of PGNAA in analyzing samples containing these elements. The method is validated by analyzing synthetic samples containing large amounts of B, Cd, Hg and Gd, the elements having high neutron absorption cross-section, in aqueous solutions and solid forms. A simple Monte-Carlo simulation to find the extent of self-shielding in the matrix is presented. The method is applied to the analysis of titanium boride alloy containing large amount of boron. The satisfactory results obtained showed the efficacy of the method of correcting for the self-shielding effects in the sample

Dependence of the specific surface area of the nuclear fuel with the matrix oxidation

International Nuclear Information System (INIS)

Gomez, F.; Quinones, J.; Iglesias, E.; Rodriguez, N.

2008-01-01

This paper is focused on the study of the changes in the specific surface area measured using BET techniques. The objective is to obtain a relation between this parameter and the change in the matrix stoichiometry (i.e., oxidation increase). None of the actual models used for extrapolating the behaviour of the spent fuel matrix under repository conditions have included this dependence yet. In this work the specific surface area of different uranium oxide were measured using N 2 (g) and Kr(g). The starting material was UO 2+x (s) with a size powder distribution lower than 20 μm. The results included in this paper shown a strong dependence on specific surface area with the matrix stoichiometry, i.e., and increase of more than one order of magnitude (SUO 2 = 6 m 2 *g -1 and SU 3 O 8 = 16.07 m 2 *g -1 ). Furthermore, the particle size distribution measured as a function of the thermal treatment done shows changes on the powder size related to the changes observed in the uranium oxide stoichiometry. (authors)

Application of workplace correction factors to dosemeter results for the assessment of personal doses at nuclear facilities

International Nuclear Information System (INIS)

Lindborg, L.; Bolognese-Milsztajn, T.; Boschung, M.; Coeck, M.; Curzio, G.; D'Errico, F.; Fiechtner, A.; Hallfarth, D.; Lievens, B.; Lillhoek, J. E.; Loevefors-Daun, A.; Lacoste, V.; Luszik-Bhadra, M.; Reginatto, M.; Schuhmacher, H.; Tanner, R.; Vanhavere, F.

2007-01-01

Ratios of H p (10) and H*(10) were determined with reference instruments in a number of workplace fields within the nuclear industry and used to derive workplace-specific correction factors. When commercial survey meter results together with these factors were applied to the results of the locally used personal dosemeters their results improved and became within 0.7 and 1.7 of the reference values or better depending on the response of the survey meter. A similar result was obtained when a correction was determined with a prototype reference instrument for H p (10) after adjustment of its response. Commercially available survey instruments both for photon and neutron H*(10) measurements agreed with the reference instruments in most cases to within 0.5-1.5. Those conclusions are derived from results reported within the EC supported EVIDOS contract. (authors)

Extracellular matrix and growth factor engineering for controlled angiogenesis in regenerative medicine

Directory of Open Access Journals (Sweden)

Mikaël M Martino

2015-04-01

Full Text Available Blood vessel growth plays a key role in regenerative medicine, both to restore blood supply to ischemic tissues and to ensure rapid vascularization of clinical-size tissue-engineered grafts. For example, vascular endothelial growth factor (VEGF is the master regulator of physiological blood vessel growth and is one of the main molecular targets of therapeutic angiogenesis approaches. However, angiogenesis is a complex process and there is a need to develop rational therapeutic strategies based on a firm understanding of basic vascular biology principles, as evidenced by the disappointing results of initial clinical trials of angiogenic factor delivery. In particular, the spatial localization of angiogenic signals in the extracellular matrix is crucial to ensure the proper assembly and maturation of new vascular structures. Here we discuss the therapeutic implications of matrix interactions of angiogenic factors, with a special emphasis on VEGF, as well as provide an overview of current approaches, based on protein and biomaterial engineering that mimic the regulatory functions of extracellular matrix to optimize the signaling microenvironment of vascular growth factors.

Evaluation of matrix effect in isotope dilution mass spectrometry based on quantitative analysis of chloramphenicol residues in milk powder

International Nuclear Information System (INIS)

Li, Xiu Qin; Yang, Zong; Zhang, Qing He; Li, Hong Mei

2014-01-01

Graphical abstract: -- Highlights: •We develop a strategy to evaluate matrix effect and its impact on the IDMS results. •Matrix effect and IDMS correction factor from different conditions are evaluated. •Ion suppression effect is observed in LLE and HLB pre-treated sample solutions. •Ion enhancement effect is found in MCX pre-treated sample solution. •IDMS correction factor in HLB and MCX solutions in three instruments is close to 1 -- Abstract: In the present study, we developed a comprehensive strategy to evaluate matrix effect (ME) and its impact on the results of isotope dilution mass spectrometry (IDMS) in analysis of chloramphenicol (CAP) residues in milk powder. Stable isotope-labeled internal standards do not always compensate ME, which brings the variation of the ratio (the peak area of analyte/the peak area of isotope). In our investigation, impact factors of this variation were studied in the extraction solution of milk powder using three mass spectrometers coupled with different ion source designs, and deuterium-labeled chloramphenicol (D5-CAP) was used as the internal standard. ME from mobile phases, sample solvents, pre-treatment methods, sample origins and instruments was evaluated, and its impact on the results of IDMS was assessed using the IDMS correction factor (θ). Our data showed that the impact of ME of mobile phase on the correction factor was significantly greater than that of sample solvent. Significant ion suppression and enhancement effects were observed in different pre-treated sample solutions. The IDMS correction factor in liquid–liquid extraction (LLE) and molecular imprinted polymer (MIP) extract with different instruments was greater or less 1.0, and the IDMS correction factor in hydrophilic lipophilic balance (HLB) and mix-mode cation exchange (MCX) extract with different instruments was all close to 1.0. To the instrument coupled with different ion source design, the impact of ME on IDMS quantitative results was

75 FR 5536 - Pipeline Safety: Control Room Management/Human Factors, Correction

Science.gov (United States)

2010-02-03

... DEPARTMENT OF TRANSPORTATION Pipeline and Hazardous Materials Safety Administration 49 CFR Parts...: Control Room Management/Human Factors, Correction AGENCY: Pipeline and Hazardous Materials Safety... following correcting amendments: PART 192--TRANSPORTATION OF NATURAL AND OTHER GAS BY PIPELINE: MINIMUM...

Resistivity Correction Factor for the Four-Probe Method: Experiment I

Science.gov (United States)

Yamashita, Masato; Yamaguchi, Shoji; Enjoji, Hideo

1988-05-01

Experimental verification of the theoretically derived resistivity correction factor (RCF) is presented. Resistivity and sheet resistance measurements by the four-probe method are made on three samples: isotropic graphite, ITO film and Au film. It is indicated that the RCF can correct the apparent variations of experimental data to yield reasonable resistivities and sheet resistances.

Fibroblast Cluster Formation on 3D Collagen Matrices Requires Cell Contraction-Dependent Fibronectin Matrix Organization

Science.gov (United States)

da Rocha-Azevedo, Bruno; Ho, Chin-Han; Grinnell, Frederick

2012-01-01

Fibroblasts incubated on 3D collagen matrices in serum or lysophosphatidic acid (LPA)-containing medium self-organize into clusters through a mechanism that requires cell contraction. However, in platelet-derived growth factor (PDGF)-containing medium, cells migrate as individuals and do not form clusters even though they constantly encounter each other. Here, we present evidence that a required function of cell contraction in clustering is formation of fibronectin fibrillar matrix. We found that in serum or LPA but not in PDGF or basal medium, cells organized FN (both serum and cellular) into a fibrillar, detergent-insoluble matrix. Cell clusters developed concomitant with FN matrix formation. FN fibrils accumulated beneath cells and along the borders of cell clusters in regions of cell-matrix tension. Blocking Rho kinase or myosin II activity prevented FN matrix assembly and cell clustering. Using siRNA silencing and function-blocking antibodies and peptides, we found that cell clustering and FN matrix assembly required α5β1 integrins and fibronectin. Cells were still able to exert contractile force and compact the collagen matrix under the latter conditions, which showed that contraction was not sufficient for cell clustering to occur. Our findings provide new insights into how procontractile (serum/LPA) and promigratory (PDGF) growth factor environments can differentially regulate FN matrix assembly by fibroblasts interacting with collagen matrices and thereby influence mesenchymal cell morphogenetic behavior under physiologic circumstances such as wound repair, morphogenesis and malignancy. PMID:23117111

Fibroblast cluster formation on 3D collagen matrices requires cell contraction dependent fibronectin matrix organization.

Science.gov (United States)

da Rocha-Azevedo, Bruno; Ho, Chin-Han; Grinnell, Frederick

2013-02-15

Fibroblasts incubated on 3D collagen matrices in serum or lysophosphatidic acid (LPA)-containing medium self-organize into clusters through a mechanism that requires cell contraction. However, in platelet-derived growth factor (PDGF)-containing medium, cells migrate as individuals and do not form clusters even though they constantly encounter each other. Here, we present evidence that a required function of cell contraction in clustering is formation of fibronectin (FN) fibrillar matrix. We found that in serum or LPA but not in PDGF or basal medium, cells organized FN (both serum and cellular) into a fibrillar, detergent-insoluble matrix. Cell clusters developed concomitant with FN matrix formation. FN fibrils accumulated beneath cells and along the borders of cell clusters in regions of cell-matrix tension. Blocking Rho kinase or myosin II activity prevented FN matrix assembly and cell clustering. Using siRNA silencing and function-blocking antibodies and peptides, we found that cell clustering and FN matrix assembly required α5β1 integrins and fibronectin. Cells were still able to exert contractile force and compact the collagen matrix under the latter conditions, which showed that contraction was not sufficient for cell clustering to occur. Our findings provide new insights into how procontractile (serum/LPA) and promigratory (PDGF) growth factor environments can differentially regulate FN matrix assembly by fibroblasts interacting with collagen matrices and thereby influence mesenchymal cell morphogenetic behavior under physiologic circumstances such as wound repair, morphogenesis and malignancy. Copyright © 2012 Elsevier Inc. All rights reserved.

Multivariate correction in laser-enhanced ionization with laser sampling

International Nuclear Information System (INIS)

Popov, A.M.; Labutin, T.A.; Sychev, D.N.; Gorbatenko, A.A.; Zorov, N.B.

2007-01-01

The opportunity of normalizing laser-enhanced ionization (LEI) signals by several reference signals (RS) measured simultaneously has been examined in view of correcting variations of laser parameters and matrix interferences. Opto-acoustic, atomic emission and non-selective ionization signals and their paired combination were used as RS for Li determination in aluminum alloys (0-6% Mg, 0-5% Cu, 0-1% Sc, 0-1% Ag). The specific normalization procedure in case of RS essential multicollinearity has been proposed. LEI and RS for each definite ablation pulse energy were plotted in Cartesian co-ordinates (x and y axes - the RS values, z axis - LEI signal). It was found that in the three-dimensional space the slope of the correlation line to the plane of RS depends on the analyte content in the solid sample. The use of this slope has therefore been proposed as a multivariate corrected analytical signal. Multivariate correlative normalization provides analytical signal free of matrix interferences for Al-Mg-Cu-Li alloys. The application of this novel approach to the determination of Li allows plotting unified calibration curves for Al-alloys of different matrix composition

Multivariate correction in laser-enhanced ionization with laser sampling

Energy Technology Data Exchange (ETDEWEB)

Popov, A.M. [Department of Chemistry, M. V. Lomonosov Moscow State University, 119992 Russia Moscow GSP-2, Leninskie Gory 1 build.3 (Russian Federation); Labutin, T.A. [Department of Chemistry, M. V. Lomonosov Moscow State University, 119992 Russia Moscow GSP-2, Leninskie Gory 1 build.3 (Russian Federation)], E-mail: timurla@laser.chem.msu.ru; Sychev, D.N.; Gorbatenko, A.A.; Zorov, N.B. [Department of Chemistry, M. V. Lomonosov Moscow State University, 119992 Russia Moscow GSP-2, Leninskie Gory 1 build.3 (Russian Federation)

2007-03-15

The opportunity of normalizing laser-enhanced ionization (LEI) signals by several reference signals (RS) measured simultaneously has been examined in view of correcting variations of laser parameters and matrix interferences. Opto-acoustic, atomic emission and non-selective ionization signals and their paired combination were used as RS for Li determination in aluminum alloys (0-6% Mg, 0-5% Cu, 0-1% Sc, 0-1% Ag). The specific normalization procedure in case of RS essential multicollinearity has been proposed. LEI and RS for each definite ablation pulse energy were plotted in Cartesian co-ordinates (x and y axes - the RS values, z axis - LEI signal). It was found that in the three-dimensional space the slope of the correlation line to the plane of RS depends on the analyte content in the solid sample. The use of this slope has therefore been proposed as a multivariate corrected analytical signal. Multivariate correlative normalization provides analytical signal free of matrix interferences for Al-Mg-Cu-Li alloys. The application of this novel approach to the determination of Li allows plotting unified calibration curves for Al-alloys of different matrix composition.

Angiogenic Type I Collagen Extracellular Matrix Integrated with Recombinant Bacteriophages Displaying Vascular Endothelial Growth Factors.

Science.gov (United States)

Yoon, Junghyo; Korkmaz Zirpel, Nuriye; Park, Hyun-Ji; Han, Sewoon; Hwang, Kyung Hoon; Shin, Jisoo; Cho, Seung-Woo; Nam, Chang-Hoon; Chung, Seok

2016-01-21

Here, a growth-factor-integrated natural extracellular matrix of type I collagen is presented that induces angiogenesis. The developed matrix adapts type I collagen nanofibers integrated with synthetic colloidal particles of recombinant bacteriophages that display vascular endothelial growth factor (VEGF). The integration is achieved during or after gelation of the type I collagen and the matrix enables spatial delivery of VEGF into a desired region. Endothelial cells that contact the VEGF are found to invade into the matrix to form tube-like structures both in vitro and in vivo, proving the angiogenic potential of the matrix. © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Electromagnetic Compatibility of Matrix Converter System

Directory of Open Access Journals (Sweden)

S. Fligl

2006-12-01

Full Text Available The presented paper deals with matrix converters pulse width modulation strategies design with emphasis on the electromagnetic compatibility. Matrix converters provide an all-silicon solution to the problem of converting AC power from one frequency to another, offering almost all the features required of an ideal static frequency changer. They possess many advantages compared to the conventional voltage or current source inverters. A matrix converter does not require energy storage components as a bulky capacitor or an inductance in the DC-link, and enables the bi-directional power flow between the power supply and load. The most of the contemporary modulation strategies are able to provide practically sinusoidal waveforms of the input and output currents with negligible low order harmonics, and to control the input displacement factor. The perspective of matrix converters regarding EMC in comparison with other types of converters is brightly evident because it is no need to use any equipment for power factor correction and current and voltage harmonics reduction. Such converter with proper control is properly compatible both with the supply mains and with the supplied load. A special digital control system was developed for the realized experimental test bed which makes it possible to achieve greater throughput of the digital control system and its variability.

Technique for information retrieval using enhanced latent semantic analysis generating rank approximation matrix by factorizing the weighted morpheme-by-document matrix

Science.gov (United States)

Chew, Peter A; Bader, Brett W

2012-10-16

A technique for information retrieval includes parsing a corpus to identify a number of wordform instances within each document of the corpus. A weighted morpheme-by-document matrix is generated based at least in part on the number of wordform instances within each document of the corpus and based at least in part on a weighting function. The weighted morpheme-by-document matrix separately enumerates instances of stems and affixes. Additionally or alternatively, a term-by-term alignment matrix may be generated based at least in part on the number of wordform instances within each document of the corpus. At least one lower rank approximation matrix is generated by factorizing the weighted morpheme-by-document matrix and/or the term-by-term alignment matrix.

Volume corrections factors in the measurement of 99mTc and 123I activities in radionuclide calibrators

International Nuclear Information System (INIS)

Correia, Amanda Ribeiro; Rezende, Eduarda Alexandre; Iwahara, Akira; Oliveira, Antonio Eduardo de; Oliveira, Estela Maria de; Tauhata, Luiz; Chaves, Taina Olivieri

2012-01-01

To determine correction factors for the variation in volume of radiopharmaceuticals in containers of different geometries, comparing the influence of such factors on the determination of 99m Tc and 123 I activity with two types of calibrators - one with ionization chamber and another with Geiger-Mueller (G-M) detector -; and to evaluate calibrators performance in the measurement of 99m Tc and 1 '2 3 I activities. Materials and Methods: Eight calibrators, 10R glass vials, 3 and 5 mL plastic syringes and 99m Tc and 123 I solutions were utilized. The correction factors were determined with basis on practical measurements of the variation in the calibrators' response according to the volume of radionuclide solution in the glass vials. The performance was evaluated according to the acceptance criterion of +- 10% accuracy required by the Brazilian standard. Results: The variation of the calibrators' response according to the variation in radionuclide volume was reasonably greater in the calibrator with G-M detector. It was also greater for 123 I than for 99m Tc. Conclusion: The results confirm that the calibrators' response depends on the radionuclide volume contained in the vials. Such dependence is more critical for the calibrators equipped with G-M detector and for 123 I as compared with 99m Tc. (author)

Power factor correction (PFC) converters feeding brushless DC ...

African Journals Online (AJOL)

This paper presents a comprehensive study of power factor correction (PFC) converters for feeding brushless DC (BLDC) motor drive. This work explores various configurations of PFC converters which are classified into five different categories of non-isolated, bridgeless (BL) non-isolated, isolated, BL-isolated PFC ...

TH-AB-201-08: Ion Chamber Dose Measurements - Problems with the Temperature-Pressure Correction Factor

Energy Technology Data Exchange (ETDEWEB)

Bourgouin, A [Carleton University, Ottawa, Ontario (Canada); McEwen, M [National Research Council, Ottawa, ON (Canada)

2016-06-15

Purpose: To investigate the behavior of ionization chambers over a wide pressure range. Methods: Three cylindrical and two parallel-plate designs of ion chamber were investigated. The ion chambers were placed in vessel where the pressure was varied from atmospheric (101 kPa) down to 5 kPa. Measurements were made using 60Co and high-energy electron beams. The pressure was measured to better than 0.1% and multiple data sets were obtained for each chamber at both polarities to investigate pressure cycling and dependency on the sign of the charge collected. Results: For all types of chamber, the ionization current, corrected using the standard PTP, showed a similar behaviour. Deviations from the standard theory were generally small for Co-60 but very significant for electron beams, up to 20 % below P = 10 kPa. The effect was found to be always larger when collecting negative charge, suggesting a dependence on free-electron collection. The most likely source of such electrons is low-energy electrons emitted from the electrodes. This signal would be independent of air pressure within the chamber cavity. The data was analyzed to extract this signal and it was found to be a non-negligible component of the ionization current at atmospheric pressure. In the case of the parallel plate chambers, the effect was approximately 0.25 %. For the cylindrical chambers the effect was larger - up to 1.2 % - and dependent on the chamber type, which would be consistent with electron emission from different wall materials. For the electron beams, the correction factor was dependent on the electron energy and approximately double that observed in 60Co. Conclusion: Measurements have indicated significant deviations of the standard pressure correction that are consistent with electron emission from chamber electrodes. This has implications for both primary standard and reference ion chamber-based dosimetry.

Evaluation of the validity of job exposure matrix for psychosocial factors at work.

Directory of Open Access Journals (Sweden)

Svetlana Solovieva

Full Text Available To study the performance of a developed job exposure matrix (JEM for the assessment of psychosocial factors at work in terms of accuracy, possible misclassification bias and predictive ability to detect known associations with depression and low back pain (LBP.We utilized two large population surveys (the Health 2000 Study and the Finnish Work and Health Surveys, one to construct the JEM and another to test matrix performance. In the first study, information on job demands, job control, monotonous work and social support at work was collected via face-to-face interviews. Job strain was operationalized based on job demands and job control using quadrant approach. In the second study, the sensitivity and specificity were estimated applying a Bayesian approach. The magnitude of misclassification error was examined by calculating the biased odds ratios as a function of the sensitivity and specificity of the JEM and fixed true prevalence and odds ratios. Finally, we adjusted for misclassification error the observed associations between JEM measures and selected health outcomes.The matrix showed a good accuracy for job control and job strain, while its performance for other exposures was relatively low. Without correction for exposure misclassification, the JEM was able to detect the association between job strain and depression in men and between monotonous work and LBP in both genders.Our results suggest that JEM more accurately identifies occupations with low control and high strain than those with high demands or low social support. Overall, the present JEM is a useful source of job-level psychosocial exposures in epidemiological studies lacking individual-level exposure information. Furthermore, we showed the applicability of a Bayesian approach in the evaluation of the performance of the JEM in a situation where, in practice, no gold standard of exposure assessment exists.

Evaluation of the validity of job exposure matrix for psychosocial factors at work.

Science.gov (United States)

Solovieva, Svetlana; Pensola, Tiina; Kausto, Johanna; Shiri, Rahman; Heliövaara, Markku; Burdorf, Alex; Husgafvel-Pursiainen, Kirsti; Viikari-Juntura, Eira

2014-01-01

To study the performance of a developed job exposure matrix (JEM) for the assessment of psychosocial factors at work in terms of accuracy, possible misclassification bias and predictive ability to detect known associations with depression and low back pain (LBP). We utilized two large population surveys (the Health 2000 Study and the Finnish Work and Health Surveys), one to construct the JEM and another to test matrix performance. In the first study, information on job demands, job control, monotonous work and social support at work was collected via face-to-face interviews. Job strain was operationalized based on job demands and job control using quadrant approach. In the second study, the sensitivity and specificity were estimated applying a Bayesian approach. The magnitude of misclassification error was examined by calculating the biased odds ratios as a function of the sensitivity and specificity of the JEM and fixed true prevalence and odds ratios. Finally, we adjusted for misclassification error the observed associations between JEM measures and selected health outcomes. The matrix showed a good accuracy for job control and job strain, while its performance for other exposures was relatively low. Without correction for exposure misclassification, the JEM was able to detect the association between job strain and depression in men and between monotonous work and LBP in both genders. Our results suggest that JEM more accurately identifies occupations with low control and high strain than those with high demands or low social support. Overall, the present JEM is a useful source of job-level psychosocial exposures in epidemiological studies lacking individual-level exposure information. Furthermore, we showed the applicability of a Bayesian approach in the evaluation of the performance of the JEM in a situation where, in practice, no gold standard of exposure assessment exists.

Space Vector Modulation for an Indirect Matrix Converter with Improved Input Power Factor

Directory of Open Access Journals (Sweden)

Nguyen Dinh Tuyen

2017-04-01

Full Text Available Pulse width modulation strategies have been developed for indirect matrix converters (IMCs in order to improve their performance. In indirect matrix converters, the LC input filter is used to remove input current harmonics and electromagnetic interference problems. Unfortunately, due to the existence of the input filter, the input power factor is diminished, especially during operation at low voltage outputs. In this paper, a new space vector modulation (SVM is proposed to compensate for the input power factor of the indirect matrix converter. Both computer simulation and experimental studies through hardware implementation were performed to verify the effectiveness of the proposed modulation strategy.

Augmenting matrix factorization technique with the combination of tags and genres

Science.gov (United States)

Ma, Tinghuai; Suo, Xiafei; Zhou, Jinjuan; Tang, Meili; Guan, Donghai; Tian, Yuan; Al-Dhelaan, Abdullah; Al-Rodhaan, Mznah

2016-11-01

Recommender systems play an important role in our daily life and are becoming popular tools for users to find what they are really interested in. Matrix factorization methods, which are popular recommendation methods, have gained high attention these years. With the rapid growth of the Internet, lots of information has been created, like social network information, tags and so on. Along with these, a few matrix factorization approaches have been proposed which incorporate the personalized information of users or items. However, except for ratings, most of the matrix factorization models have utilized only one kind of information to understand users' interests. Considering the sparsity of information, in this paper, we try to investigate the combination of different information, like tags and genres, to reveal users' interests accurately. With regard to the generalization of genres, a constraint is added when genres are utilized to find users' similar ;soulmates;. In addition, item regularizer is also considered based on latent semantic indexing (LSI) method with the item tags. Our experiments are conducted on two real datasets: Movielens dataset and Douban dataset. The experimental results demonstrate that the combination of tags and genres is really helpful to reveal users' interests.

Correcting the effects of the matrix using capture gamma-ray spectrometry: Application to measurement by Active Neutron Interrogation; Correction des effets de matrice par spectrometrie des rayonnements gamma de capture: Application a la mesure par Interrogation Neutronique Active (I.N.A.)

Energy Technology Data Exchange (ETDEWEB)

Baudry, G.

2003-11-15

In the field of the measurement of low masses of fissile material ({sup 235}U, {sup 239}Pu, {sup 241}Pu) in radioactive waste drums, the Active Neutron Interrogation is a non-destructive method achieving good results. It does however remain reliant upon uncertainties related to the matrix effects on interrogation and fission neutrons. The aim of this thesis is to develop a correction method able to take into account these matrix effects by quantifying the amount of absorbent materials (chlorine and hydrogen) in a 118- liter homogeneous matrix. The main idea is to use the gamma-ray spectrometry of gamma emitted by neutron captures to identify and quantify the composition of the matrix. An indicator from its chlorine content is then deduced in order to choose the calibration coefficient which best represents the real composition of the matrix. This document firstly presents the needs of control and characterization of radioactive objects, and the means used in the field of nuclear measurement. Emphases is put in particular on the Active Neutron Interrogation method. The matrices of interest are those made of light technological waste (density {<=} 0,4 g/cm{sup 3}) containing hydrogenated and chlorinated materials. The advantages of gamma-rays emitted by neutron captures for the determination of a chlorine content indicator of the matrices and the principles of the correction method are then explained. Measurements have been firstly realized with an existing Neutron Interrogation device (PROMETHEE 6). Such measurements have proven its inadequacy: no signal from the matrix hydrogen was detected, due to an intense signal from the polyethylene contained in some cell elements. Moreover, the matrix chlorine content appeared difficult to be measured. A new and specific device, named REGAIN and dedicated to active gamma-rays spectrometry, was defined with the Monte-Carlo N-Particle (MCNP) code. The experiments conducted with this new device made it possible to detect the

Relation between the 2{nu}{beta}{beta} and 0{nu}{beta}{beta} nuclear matrix elements

Energy Technology Data Exchange (ETDEWEB)

Vogel, Petr [Kellogg Radiation Laboratory, Caltech, Pasadena, CA 91125 (United States); Simkovic, Fedor [Department of Nuclear Physics and Biophysics, Comenius University, Mlynska dolina F1, SK-84248 Bratislava (Slovakia)

2011-12-16

A formal relation between the GT part of the nuclear matrix elements M{sub GT}{sup 0{nu}} of 0{nu}{beta}{beta} decay and the closure matrix elements M{sub cl}{sup 2{nu}} of 2{nu}{beta}{beta} decay is established. This relation is based on the integral representation of these quantities in terms of their dependence on the distance r between the two nucleons undergoing transformation. We also discuss the difficulties in determining the correct values of the closure 2{nu}{beta}{beta} decay matrix elements.

Evaluating the efficacy of Regulated 12-Session Matrix Model in reducing susceptibility in methamphetamine-dependent individuals

Directory of Open Access Journals (Sweden)

Zahra Amiri

2016-02-01

Full Text Available Methamphetamine (abuse have gained popularity among youth and is increasingly become a part of mainstream culture. Methamphetamine(abuse is dangerous because of its wide range adverse outcomes and hazardous sustaining side effects. Its dependence is hardly withdrawn by routine therapeutic methods. This study is devoted to evaluate the efficacy of Regulated 12-Session Matrix Model in outpatient methamphetamine-dependent individuals. 24 individuals were chosen according to inclusion/exclusion criteria of the study and randomly assigned to equal experimental (age range 19-41; mean age: 46.9 and control groups (age range: 21-42; mean age: 27.8. Experimental group members partook Regulated 12-Session Matrix Model once a week in 12 consecutive weeks, while control group members remained at waitlist. Independent t-test in 12th week showed that experimental group had lower methamphetamine use, comparing to control group (p<.05.Phillai’s Trace, Wilk’s Lambda, HotellingLawley's trace, and Roy's largest root showed that there are significant association between experimental and control groups in reduction of methamphetamine-use lapse (p<.05.Within-subject F ratio revealed that “methamphetamine use” was significantly reduced in experimental group after clinical intervention (p<.001. Findings of the study indicate the efficacy of Regulated 12-Session Matrix Model in craving management and control as well as reduction of lapse and substance (abuse in methamphetamine-dependent patients. It appears that the Regulated 12-Session Matrix Model would be a new reliable solution to treat methamphetamine-dependence in Iran and other alike cultural and social atmospheres. Limitations and future implications are discussed.

Insulin-like growth factor I has independent effects on bone matrix formation and cell replication

International Nuclear Information System (INIS)

Hock, J.M.; Centrella, M.; Canalis, E.

1988-01-01

The effects of insulin-like growth factor-I (IGF-I) and insulin on bone matrix synthesis and bone cell replication were studied in cultured 21-day-old fetal rat calvariae. Histomorphometry techniques were developed to measure the incorporation of [2,3- 3 H]proline and [methyl- 3 H]thymidine into bone matrix and bone cell nuclei, respectively, using autoradiographs of sagittal sections of calvariae cultured with IGF-I, insulin, or vehicle for up to 96 h. To confirm an effect on bone formation, IGF-I was also studied for its effects on [ 3 H]proline incorporation into collagenase-digestible protein (CDP) and noncollagen protein and on [ 3 H]thymidine incorporation into acid-precipitable material (DNA). IGF-I at 10(-9)-10(-7) M significantly increased the rate of bone matrix apposition and CDP after 24 h by 45-50% and increased cell labeling by 8-fold in the osteoprogenitor cell zone, by 4-fold in the osteoblast cell zone, and by 2-fold in the periosteal fibroblast zone. Insulin at 10(-9)-10(-6) M also increased matrix apposition rate and CDP by 40-50%, but increased cell labeling by 2-fold only at a concentration of 10(-7) M or higher and then only in the osteoprogenitor cell zone. When hydroxyurea was added to IGF-I-treated bones, the effects of IGF-I on DNA synthesis were abolished, but the increase in bone matrix apposition induced by IGF-I was only partly diminished. In conclusion, IGF-I stimulates matrix synthesis in calvariae, an effect that is partly, although not completely, dependent on its stimulatory effect on DNA synthesis

Higgs mass dependence of electroweak radiative corrections and the triviality bound

NARCIS (Netherlands)

Cortese, S.; Pallante, E.; Petronzio, R.

1993-01-01

We discuss how the existence of a triviality bound for the Higgs sector of the standard model does influence the dependence of radiative corrections upon the Higgs mass. The lowering of the Landau pole with increasing Higgs mass implies that the sensitivity to Higgs mass values beyond ≈ 500 GeV is

Correction factors for photon beam quality for cylindrical ionization chambers: Monte Carlo calculations by using the PENELOPE code

International Nuclear Information System (INIS)

Barreras Caballero, A. A.; Hernandez Garcia, J.J.; Alfonso Laguardia, R.

2009-01-01

Were directly determined correction factors depending on the type camera beam quality, k, Q, and kQ, Qo, instead of the product (w, air p) Q, for three type cylindrical ionization chambers Pinpoint and divergent monoenergetic beams of photons in a wide range of energies (4-20 MV). The method of calculation used dispenses with the approaches taken in the classic procedure considered independent of braking power ratios and the factors disturbance of the camera. A detailed description of the geometry and materials chambers were supplied by the manufacturer and used as data input for the system 2006 of PENELOPE Monte Carlo calculation using a User code that includes correlated sampling, and forced interactions division of particles. We used a photon beam Co-60 as beam reference for calculating the correction factors for beam quality. No data exist for the cameras PTW 31014, 31015 and 31016 in the TRS-398 at they do not compare the results with data calculated or determined experimentally by other authors. (author)

Analysis of risk factors for hydrocephalus development in newborn infants with germinal matrix hemorrhage.

Science.gov (United States)

Romero, L; Ros, B; Arráez, M A; Ríus, F; González, L; Martín, A; Carrasco, A; Segura, M

2015-10-01

The aim of this study was to analyze risk factors for the development of hydrocephalus in newborn infants with germinal matrix (GM) hemorrhage. The study comprised 271 patients admitted to Carlos Haya University Hospital in Malaga with GM hemorrhage. The following data were recorded: gestational age, gender, twin birth, head circumference at birth, weight at birth, and Papile grade. Severe obstetrical (abruption, chorioamnionitis, pregnancy-induced hypertension, tocolytic treatment) and neonatal disorders (respiratory distress syndrome, neonatal infection, coagulation disorder, patent ductus arteriosus, necrotizing enterocolitis) were also recorded. Symptomatic hydrocephalus was diagnosed in the event of a progressive increase in head circumference and ventricular indices requiring shunting. Of the 271 patients, 139 (51%) developed posthemorrhagic ventriculomegaly; 47 patients (17%) developed symptomatic hydrocephalus and needed shunt implantation. We found a significant relationship between the development of symptomatic hydrocephalus and Papile grade, lower gestational age, lower birth weight, twin birth, and neonatal infection. Awareness of risk factors for the development of hydrocephalus in newborn infants with GM hemorrhage should be emphasized in order to enable an early diagnosis of ventriculomegaly and symptomatic hydrocephalus and thus make a correct therapeutic decision.

An Elementary Proof of the Polynomial Matrix Spectral Factorization Theorem

OpenAIRE

Ephremidze, Lasha

2010-01-01

A very simple and short proof of the polynomial matrix spectral factorization theorem (on the unit circle as well as on the real line) is presented, which relies on elementary complex analysis and linear algebra.

Multiplicity dependence of matrix-induced frequency shifts for atomic transitions of the group 12 metals in rare gas solids

International Nuclear Information System (INIS)

Laursen, S.L.; Cartland, H.E.

1991-01-01

Atomic resonances of the group 12 metal atoms, Hg, Cd, and Zn, undergo frequency shifts from the gas phase atomic line when trapped in rare gas matrices of Ar, Kr, and Xe at 12 K. As expected, the shifts are approximately linear in polarizability of the rare gas, but the slope of this line depends on whether the transition in question is 1 P 1 left-arrow 1 S 0 or 3 P 1 left-arrow 1 S 0 . Thus the matrix-induced frequency shift is dependent on the singlet or triplet nature of the excited state as well as on the matrix material. This dependence on multiplicity is discussed in terms of interactions between the excited-state atomic orbitals and the matrix. The results are compared to matrix studies of other metals and to related gas-phase work on diatomic van der Waals complexes of group 12 metals with rare gases

Multiple and dependent scattering by densely packed discrete spheres: Comparison of radiative transfer and Maxwell theory

International Nuclear Information System (INIS)

Ma, L.X.; Tan, J.Y.; Zhao, J.M.; Wang, F.Q.; Wang, C.A.

2017-01-01

The radiative transfer equation (RTE) has been widely used to deal with multiple scattering of light by sparsely and randomly distributed discrete particles. However, for densely packed particles, the RTE becomes questionable due to strong dependent scattering effects. This paper examines the accuracy of RTE by comparing with the exact electromagnetic theory. For an imaginary spherical volume filled with randomly distributed, densely packed spheres, the RTE is solved by the Monte Carlo method combined with the Percus–Yevick hard model to consider the dependent scattering effect, while the electromagnetic calculation is based on the multi-sphere superposition T-matrix method. The Mueller matrix elements of the system with different size parameters and volume fractions of spheres are obtained using both methods. The results verify that the RTE fails to deal with the systems with a high-volume fraction due to the dependent scattering effects. Apart from the effects of forward interference scattering and coherent backscattering, the Percus–Yevick hard sphere model shows good accuracy in accounting for the far-field interference effects for medium or smaller size parameters (up to 6.964 in this study). For densely packed discrete spheres with large size parameters (equals 13.928 in this study), the improvement of dependent scattering correction tends to deteriorate. The observations indicate that caution must be taken when using RTE in dealing with the radiative transfer in dense discrete random media even though the dependent scattering correction is applied. - Highlights: • The Muller matrix of randomly distributed, densely packed spheres are investigated. • The effects of multiple scattering and dependent scattering are analyzed. • The accuracy of radiative transfer theory for densely packed spheres is discussed. • Dependent scattering correction takes effect at medium size parameter or smaller. • Performance of dependent scattering correction

Extracellular Matrix-Regulated Gene Expression RequiresCooperation of SWI/SNF and Transcription Factors

Energy Technology Data Exchange (ETDEWEB)

Xu, Ren; Spencer, Virginia A.; Bissell, Mina J.

2006-05-25

Extracellular cues play crucial roles in the transcriptional regulation of tissue-specific genes, but whether and how these signals lead to chromatin remodeling is not understood and subject to debate. Using chromatin immunoprecipitation (ChIP) assays and mammary-specific genes as models, we show here that extracellular matrix (ECM) molecules and prolactin cooperate to induce histone acetylation and binding of transcription factors and the SWI/SNF complex to the {beta}- and ?-casein promoters. Introduction of a dominant negative Brg1, an ATPase subunit of SWI/SNF complex, significantly reduced both {beta}- and ?-casein expression, suggesting that SWI/SNF-dependent chromatin remodeling is required for transcription of mammary-specific genes. ChIP analyses demonstrated that the ATPase activity of SWI/SNF is necessary for recruitment of RNA transcriptional machinery, but not for binding of transcription factors or for histone acetylation. Coimmunoprecipitation analyses showed that the SWI/SNF complex is associated with STAT5, C/EBP{beta}, and glucocorticoid receptor (GR). Thus, ECM- and prolactin-regulated transcription of the mammary-specific casein genes requires the concerted action of chromatin remodeling enzymes and transcription factors.

Uncertainty of relative sensitivity factors in glow discharge mass spectrometry

Science.gov (United States)

Meija, Juris; Methven, Brad; Sturgeon, Ralph E.

2017-10-01

The concept of the relative sensitivity factors required for the correction of the measured ion beam ratios in pin-cell glow discharge mass spectrometry is examined in detail. We propose a data-driven model for predicting the relative response factors, which relies on a non-linear least squares adjustment and analyte/matrix interchangeability phenomena. The model provides a self-consistent set of response factors for any analyte/matrix combination of any element that appears as either an analyte or matrix in at least one known response factor.

Semi-Supervised Half-Quadratic Nonnegative Matrix Factorization for Face Recognition

KAUST Repository

Alghamdi, Masheal M.

2014-01-01

complications to the face recognition research. Many algorithms are devoted to solving the face recognition problem, among which the family of nonnegative matrix factorization (NMF) algorithms has been widely used as a compact data representation method

Topographic Correction Module at Storm (TC@Storm)

Science.gov (United States)

Zaksek, K.; Cotar, K.; Veljanovski, T.; Pehani, P.; Ostir, K.

2015-04-01

Different solar position in combination with terrain slope and aspect result in different illumination of inclined surfaces. Therefore, the retrieved satellite data cannot be accurately transformed to the spectral reflectance, which depends only on the land cover. The topographic correction should remove this effect and enable further automatic processing of higher level products. The topographic correction TC@STORM was developed as a module within the SPACE-SI automatic near-real-time image processing chain STORM. It combines physical approach with the standard Minnaert method. The total irradiance is modelled as a three-component irradiance: direct (dependent on incidence angle, sun zenith angle and slope), diffuse from the sky (dependent mainly on sky-view factor), and diffuse reflected from the terrain (dependent on sky-view factor and albedo). For computation of diffuse irradiation from the sky we assume an anisotropic brightness of the sky. We iteratively estimate a linear combination from 10 different models, to provide the best results. Dependent on the data resolution, we mask shades based on radiometric (image) or geometric properties. The method was tested on RapidEye, Landsat 8, and PROBA-V data. Final results of the correction were evaluated and statistically validated based on various topography settings and land cover classes. Images show great improvements in shaded areas.

Metal matrix composites: History, status, factors and future

Science.gov (United States)

Cyriac, Ajith James

The history, status, and future of metal matrix composites are presented by evaluating the progression of available literature through time. The trends that existed and issues that still prevail are discussed and a prediction of the future for MMCs is presented. The factors that govern the performance of metal matrix composites are also discussed. In many developed countries and in several developing countries there exists continued interest in MMCs. Researchers tried numerous combinations of matrices and reinforcements since work strictly on MMCs began in the 1950s. This led to developments for aerospace and defense applications, but resultant commercial applications were limited. The introduction of ceramic whiskers as reinforcement and the development of 'in-situ' eutectics in the 1960s aided high temperature applications in aircraft engines. In the late 1970s the automobile industries started to take MMCs seriously. In the last 20 years, MMCs evolved from laboratories to a class of materials with numerous applications and commercial markets. After the collapse of the Berlin Wall, prevailing order in the world changed drastically. This effect was evident in the progression of metal matrix composites. The internet connected the world like never before and tremendous information was available for researchers around the world. Globalization and the internet resulted in the transformation of the world to a more level playing field, and this effect is evident in the nature and source of research on metal matrix composites happening around the world.

Time-dependent occupation numbers in reduced-density-matrix-functional theory: Application to an interacting Landau-Zener model

International Nuclear Information System (INIS)

Requist, Ryan; Pankratov, Oleg

2011-01-01

We prove that if the two-body terms in the equation of motion for the one-body reduced density matrix are approximated by ground-state functionals, the eigenvalues of the one-body reduced density matrix (occupation numbers) remain constant in time. This deficiency is related to the inability of such an approximation to account for relative phases in the two-body reduced density matrix. We derive an exact differential equation giving the functional dependence of these phases in an interacting Landau-Zener model and study their behavior in short- and long-time regimes. The phases undergo resonances whenever the occupation numbers approach the boundaries of the interval [0,1]. In the long-time regime, the occupation numbers display correlation-induced oscillations and the memory dependence of the functionals assumes a simple form.

Calculation of the Cholesky factor directly from the stiffness matrix of the structural element

International Nuclear Information System (INIS)

Prates, C.L.M.; Soriano, H.L.

1978-01-01

The analysis of the structures of nuclear power plants requires the evaluation of the internal forces. This is attained by the solution of a system of equations. This solution takes most of the computing time and memory. One of the ways it can be achieved is based on the Cholesky factor. The structural matrix of the coeficients is transformed into an upper triangular matrix by the Cholesky decomposition. Cholesky factor can be obtained directly from the stiffness matrix of the structural element. The result can thus be obtained in a more precise and quick way. (Author)

Temperature Dependence of Electrical Resistance of Woven Melt-Infiltrated SiCf/SiC Ceramic Matrix Composites

Science.gov (United States)

Appleby, Matthew P.; Morscher, Gregory N.; Zhu, Dongming

2016-01-01

Recent studies have successfully shown the use of electrical resistance (ER)measurements to monitor room temperature damage accumulation in SiC fiber reinforced SiC matrix composites (SiCf/SiC) Ceramic Matrix Composites (CMCs). In order to determine the feasibility of resistance monitoring at elevated temperatures, the present work investigates the temperature dependent electrical response of various MI (Melt Infiltrated)-CVI (Chemical Vapor Infiltrated) SiC/SiC composites containing Hi-Nicalon Type S, Tyranno ZMI and SA reinforcing fibers. Test were conducted using a commercially available isothermal testing apparatus as well as a novel, laser-based heating approach developed to more accurately simulate thermomechanical testing of CMCs. Secondly, a post-test inspection technique is demonstrated to show the effect of high-temperature exposure on electrical properties. Analysis was performed to determine the respective contribution of the fiber and matrix to the overall composite conductivity at elevated temperatures. It was concluded that because the silicon-rich matrix material dominates the electrical response at high temperature, ER monitoring would continue to be a feasible method for monitoring stress dependent matrix cracking of melt-infiltrated SiC/SiC composites under high temperature mechanical testing conditions. Finally, the effect of thermal gradients generated during localized heating of tensile coupons on overall electrical response of the composite is determined.

Importance of Lorentz structure in the parton model: Target mass corrections, transverse momentum dependence, positivity bounds

International Nuclear Information System (INIS)

D'Alesio, U.; Leader, E.; Murgia, F.

2010-01-01

We show that respecting the underlying Lorentz structure in the parton model has very strong consequences. Failure to insist on the correct Lorentz covariance is responsible for the existence of contradictory results in the literature for the polarized structure function g 2 (x), whereas with the correct imposition we are able to derive the Wandzura-Wilczek relation for g 2 (x) and the target-mass corrections for polarized deep inelastic scattering without recourse to the operator product expansion. We comment briefly on the problem of threshold behavior in the presence of target-mass corrections. Careful attention to the Lorentz structure has also profound implications for the structure of the transverse momentum dependent parton densities often used in parton model treatments of hadron production, allowing the k T dependence to be derived explicitly. It also leads to stronger positivity and Soffer-type bounds than usually utilized for the collinear densities.

Non-negative matrix factorization by maximizing correntropy for cancer clustering

KAUST Repository

Wang, Jim Jing-Yan; Wang, Xiaolei; Gao, Xin

2013-01-01

Background: Non-negative matrix factorization (NMF) has been shown to be a powerful tool for clustering gene expression data, which are widely used to classify cancers. NMF aims to find two non-negative matrices whose product closely approximates the original matrix. Traditional NMF methods minimize either the l2 norm or the Kullback-Leibler distance between the product of the two matrices and the original matrix. Correntropy was recently shown to be an effective similarity measurement due to its stability to outliers or noise.Results: We propose a maximum correntropy criterion (MCC)-based NMF method (NMF-MCC) for gene expression data-based cancer clustering. Instead of minimizing the l2 norm or the Kullback-Leibler distance, NMF-MCC maximizes the correntropy between the product of the two matrices and the original matrix. The optimization problem can be solved by an expectation conditional maximization algorithm.Conclusions: Extensive experiments on six cancer benchmark sets demonstrate that the proposed method is significantly more accurate than the state-of-the-art methods in cancer clustering. 2013 Wang et al.; licensee BioMed Central Ltd.

Non-negative matrix factorization by maximizing correntropy for cancer clustering

KAUST Repository

Wang, Jim Jing-Yan

2013-03-24

Background: Non-negative matrix factorization (NMF) has been shown to be a powerful tool for clustering gene expression data, which are widely used to classify cancers. NMF aims to find two non-negative matrices whose product closely approximates the original matrix. Traditional NMF methods minimize either the l2 norm or the Kullback-Leibler distance between the product of the two matrices and the original matrix. Correntropy was recently shown to be an effective similarity measurement due to its stability to outliers or noise.Results: We propose a maximum correntropy criterion (MCC)-based NMF method (NMF-MCC) for gene expression data-based cancer clustering. Instead of minimizing the l2 norm or the Kullback-Leibler distance, NMF-MCC maximizes the correntropy between the product of the two matrices and the original matrix. The optimization problem can be solved by an expectation conditional maximization algorithm.Conclusions: Extensive experiments on six cancer benchmark sets demonstrate that the proposed method is significantly more accurate than the state-of-the-art methods in cancer clustering. 2013 Wang et al.; licensee BioMed Central Ltd.

The Effectiveness of Matrix Model in Relapse Prevention and Coping Skills Enhancement in Participants with Substance Dependency

Directory of Open Access Journals (Sweden)

Ali Farnam

2013-05-01

Full Text Available Aim: The aim of this study was to determine the effectiveness of Matrix model in relapse prevention and enhancement of coping skills in participants with opiate substance dependency. Method: In a semi-experimental study, 23 participants with diagnosis of opiate dependency who successfully detoxified, selected by cluster random sampling and they were divided into two experimental and control groups. The experimental group received 32 sessions of Matrix model training and the control group did not receive any treatment. All subjects were assessed by alcohol abuse coping response inventory (AACRI and Morphine test before treatment, randomly during treatment, after treatment, and after 3-months follow up stage. Results: The results showed that experimental and control groups had a significant differed in relapse rates. In addition, Analysis of Covariance (ANCOVA showed a significant difference between two groups in coping skills enhancement at periods of post test and follow up. Conclusion: With consideration of the results of the present study indicated that matrix model is effective in relapse prevention and coping skills enhancement in people with opiate substance dependency.

Refined shear correction factor for very thick simply supported and uniformly loaded isosceles right triangular auxetic plates

International Nuclear Information System (INIS)

Lim, Teik-Cheng

2016-01-01

For moderately thick plates, the use of First order Shear Deformation Theory (FSDT) with a constant shear correction factor of 5/6 is sufficient to take into account the plate deflection arising from transverse shear deformation. For very thick plates, the use of Third order Shear Deformation Theory (TSDT) is preferred as it allows the shear strain distribution to be varied through the plate thickness. Therefore no correction factor is required in TSDT, unlike FSDT. Due to the complexity involved in TSDT, this paper obtains a more accurate shear correction factor for use in FSDT of very thick simply supported and uniformly loaded isosceles right triangular plates based on the TSDT. By matching the maximum deflections for this plate according to FSDT and TSDT, a variable shear correction factor is obtained. Results show that the shear correction factor for the simplified TSDT, i.e. 14/17, is least accurate. The commonly adopted shear correction factor of 5/6 in FSDT is valid only for very thin or highly auxetic plates. This paper provides a variable shear correction for FSDT deflection that matches the plate deflection by TSDT. This variable shear correction factor allows designers to justify the use of a commonly adopted shear correction factor of 5/6 even for very thick plates as long as the Poisson’s ratio of the plate material is sufficiently negative. (paper)

Time-dependent reduced density matrix functional theory applied to laser-driven, correlated two-electron dynamics

Energy Technology Data Exchange (ETDEWEB)

Brics, Martins; Kapoor, Varun; Bauer, Dieter [Institut fuer Physik, Universitaet Rostock, 18051 Rostock (Germany)

2013-07-01

Time-dependent density functional theory (TDDFT) with known and practicable exchange-correlation potentials does not capture highly correlated electron dynamics such as single-photon double ionization, autoionization, or nonsequential ionization. Time-dependent reduced density matrix functional theory (TDRDMFT) may remedy these problems. The key ingredients in TDRDMFT are the natural orbitals (NOs), i.e., the eigenfunctions of the one-body reduced density matrix (1-RDM), and the occupation numbers (OCs), i.e., the respective eigenvalues. The two-body reduced density matrix (2-RDM) is then expanded in NOs, and equations of motion for the NOs can be derived. If the expansion coefficients of the 2-RDM were known exactly, the problem at hand would be solved. In practice, approximations have to be made. We study the prospects of TDRDMFT following a top-down approach. We solve the exact two-electron time-dependent Schroedinger equation for a model Helium atom in intense laser fields in order to study highly correlated phenomena such as the population of autoionizing states or single-photon double ionization. From the exact wave function we calculate the exact NOs, OCs, the exact expansion coefficients of the 2-RDM, and the exact potentials in the equations of motion. In that way we can identify how many NOs and which level of approximations are necessary to capture such phenomena.

All-at-once Optimization for Coupled Matrix and Tensor Factorizations

DEFF Research Database (Denmark)

Evrim, Acar Ataman; Kolda, Tamara G.; Dunlavy, Daniel M.

2011-01-01

.g., the person by person social network matrix or the restaurant by category matrix, and higher-order tensors, e.g., the "ratings" tensor of the form restaurant by meal by person. In this paper, we are particularly interested in fusing data sets with the goal of capturing their underlying latent structures. We...... formulate this problem as a coupled matrix and tensor factorization (CMTF) problem where heterogeneous data sets are modeled by fitting outer-product models to higher-order tensors and matrices in a coupled manner. Unlike traditional approaches solving this problem using alternating algorithms, we propose...... an all-at-once optimization approach called CMTF-OPT (CMTF-OPTimization), which is a gradient-based optimization approach for joint analysis of matrices and higher-order tensors. We also extend the algorithm to handle coupled incomplete data sets. Using numerical experiments, we demonstrate...

Journal Impact Factor: Do the Numerator and Denominator Need Correction?

Science.gov (United States)

Liu, Xue-Li; Gai, Shuang-Shuang; Zhou, Jing

2016-01-01

To correct the incongruence of document types between the numerator and denominator in the traditional impact factor (IF), we make a corresponding adjustment to its formula and present five corrective IFs: IFTotal/Total, IFTotal/AREL, IFAR/AR, IFAREL/AR, and IFAREL/AREL. Based on a survey of researchers in the fields of ophthalmology and mathematics, we obtained the real impact ranking of sample journals in the minds of peer experts. The correlations between various IFs and questionnaire score were analyzed to verify their journal evaluation effects. The results show that it is scientific and reasonable to use five corrective IFs for journal evaluation for both ophthalmology and mathematics. For ophthalmology, the journal evaluation effects of the five corrective IFs are superior than those of traditional IF: the corrective effect of IFAR/AR is the best, IFAREL/AR is better than IFTotal/Total, followed by IFTotal/AREL, and IFAREL/AREL. For mathematics, the journal evaluation effect of traditional IF is superior than those of the five corrective IFs: the corrective effect of IFTotal/Total is best, IFAREL/AR is better than IFTotal/AREL and IFAREL/AREL, and the corrective effect of IFAR/AR is the worst. In conclusion, not all disciplinary journal IF need correction. The results in the current paper show that to correct the IF of ophthalmologic journals may be valuable, but it seems to be meaningless for mathematic journals. PMID:26977697

Multithreading for synchronization tolerance in matrix factorization

International Nuclear Information System (INIS)

Buttari, Alfredo; Dongarra, Jack; Husbands, Parry; Kurzak, Jakub; Yelick, Katherine

2007-01-01

Physical constraints such as power, leakage and pin bandwidth are currently driving the HPC industry to produce systems with unprecedented levels of concurrency. In these parallel systems, synchronization and memory operations are becoming considerably more expensive than before. In this work we study parallel matrix factorization codes and conclude that they need to be re-engineered to avoid unnecessary (and expensive) synchronization. We propose the use of multithreading combined with intelligent schedulers and implement representative algorithms in this style. Our results indicate that this strategy can significantly outperform traditional codes

Nonnegative Matrix Factorization with Rank Regularization and Hard Constraint.

Science.gov (United States)

Shang, Ronghua; Liu, Chiyang; Meng, Yang; Jiao, Licheng; Stolkin, Rustam

2017-09-01

Nonnegative matrix factorization (NMF) is well known to be an effective tool for dimensionality reduction in problems involving big data. For this reason, it frequently appears in many areas of scientific and engineering literature. This letter proposes a novel semisupervised NMF algorithm for overcoming a variety of problems associated with NMF algorithms, including poor use of prior information, negative impact on manifold structure of the sparse constraint, and inaccurate graph construction. Our proposed algorithm, nonnegative matrix factorization with rank regularization and hard constraint (NMFRC), incorporates label information into data representation as a hard constraint, which makes full use of prior information. NMFRC also measures pairwise similarity according to geodesic distance rather than Euclidean distance. This results in more accurate measurement of pairwise relationships, resulting in more effective manifold information. Furthermore, NMFRC adopts rank constraint instead of norm constraints for regularization to balance the sparseness and smoothness of data. In this way, the new data representation is more representative and has better interpretability. Experiments on real data sets suggest that NMFRC outperforms four other state-of-the-art algorithms in terms of clustering accuracy.

Empirical Derivation of Correction Factors for Human Spiral Ganglion Cell Nucleus and Nucleolus Count Units.

Science.gov (United States)

Robert, Mark E; Linthicum, Fred H

2016-01-01

Profile count method for estimating cell number in sectioned tissue applies a correction factor for double count (resulting from transection during sectioning) of count units selected to represent the cell. For human spiral ganglion cell counts, we attempted to address apparent confusion between published correction factors for nucleus and nucleolus count units that are identical despite the role of count unit diameter in a commonly used correction factor formula. We examined a portion of human cochlea to empirically derive correction factors for the 2 count units, using 3-dimensional reconstruction software to identify double counts. The Neurotology and House Histological Temporal Bone Laboratory at University of California at Los Angeles. Using a fully sectioned and stained human temporal bone, we identified and generated digital images of sections of the modiolar region of the lower first turn of cochlea, identified count units with a light microscope, labeled them on corresponding digital sections, and used 3-dimensional reconstruction software to identify double-counted count units. For 25 consecutive sections, we determined that double-count correction factors for nucleus count unit (0.91) and nucleolus count unit (0.92) matched the published factors. We discovered that nuclei and, therefore, spiral ganglion cells were undercounted by 6.3% when using nucleolus count units. We determined that correction factors for count units must include an element for undercounting spiral ganglion cells as well as the double-count element. We recommend a correction factor of 0.91 for the nucleus count unit and 0.98 for the nucleolus count unit when using 20-µm sections. © American Academy of Otolaryngology—Head and Neck Surgery Foundation 2015.

Omentin-1 prevents cartilage matrix destruction by regulating matrix metalloproteinases.

Science.gov (United States)

Li, Zhigang; Liu, Baoyi; Zhao, Dewei; Wang, BenJie; Liu, Yupeng; Zhang, Yao; Li, Borui; Tian, Fengde

2017-08-01

Matrix metalloproteinases (MMPs) play a crucial role in the degradation of the extracellular matrix and pathological progression of osteoarthritis (OA). Omentin-1 is a newly identified anti-inflammatory adipokine. Little information regarding the protective effects of omentin-1 in OA has been reported before. In the current study, our results indicated that omentin-1 suppressed expression of MMP-1, MMP-3, and MMP-13 induced by the proinflammatory cytokine interleukin-1β (IL-1β) at both the mRNA and protein levels in human chondrocytes. Importantly, administration of omentin-1 abolished IL-1β-induced degradation of type II collagen (Col II) and aggrecan, the two major extracellular matrix components in articular cartilage, in a dose-dependent manner. Mechanistically, omentin-1 ameliorated the expression of interferon regulatory factor 1 (IRF-1) by blocking the JAK-2/STAT3 pathway. Our results indicate that omentin-1 may have a potential chondroprotective therapeutic capacity. Copyright © 2017 Elsevier Masson SAS. All rights reserved.

Large-Scale Distributed Bayesian Matrix Factorization using Stochastic Gradient MCMC

NARCIS (Netherlands)

Ahn, S.; Korattikara, A.; Liu, N.; Rajan, S.; Welling, M.

2015-01-01

Despite having various attractive qualities such as high prediction accuracy and the ability to quantify uncertainty and avoid ovrfitting, Bayesian Matrix Factorization has not been widely adopted because of the prohibitive cost of inference. In this paper, we propose a scalable distributed Bayesian

Quasi-stationary states of an electron with linearly dependent effective mass in an open nanostructure within transmission coefficient and S-matrix methods

Science.gov (United States)

Seti, Julia; Tkach, Mykola; Voitsekhivska, Oxana

2018-03-01

The exact solutions of the Schrödinger equation for a double-barrier open semiconductor plane nanostructure are obtained by using two different approaches, within the model of the rectangular potential profile and the continuous position-dependent effective mass of the electron. The transmission coefficient and scattering matrix are calculated for the double-barrier nanostructure. The resonance energies and resonance widths of the electron quasi-stationary states are analyzed as a function of the size of the near-interface region between wells and barriers, where the effective mass linearly depends on the coordinate. It is established that, in both methods, the increasing size affects in a qualitatively similar way the spectral characteristics of the states, shifting the resonance energies into the low- or high-energy region and increasing the resonance widths. It is shown that the relative difference of resonance energies and widths of a certain state, obtained in the model of position-dependent effective mass and in the widespread abrupt model in physically correct range of near-interface sizes, does not exceed 0.5% and 5%, respectively, independently of the other geometrical characteristics of the structure.

Matrix elements of vibration kinetic energy operator of tetrahedral molecules in non-orthogonal-dependent coordinates

Science.gov (United States)

Protasevich, Alexander E.; Nikitin, Andrei V.

2018-01-01

In this work, we propose an algorithm for calculating the matrix elements of the kinetic energy operator for tetrahedral molecules. This algorithm uses the dependent six-angle coordinates (6A) and takes into account the full symmetry of molecules. Unlike A.V. Nikitin, M. Rey, and Vl. G. Tyuterev who operate with the kinetic energy operator only in Radau orthogonal coordinates, we consider a general case. The matrix elements are shown to be a sum of products of one-dimensional integrals.

An integrating factor matrix method to find first integrals

International Nuclear Information System (INIS)

Saputra, K V I; Quispel, G R W; Van Veen, L

2010-01-01

In this paper we develop an integrating factor matrix method to derive conditions for the existence of first integrals. We use this novel method to obtain first integrals, along with the conditions for their existence, for two- and three-dimensional Lotka-Volterra systems with constant terms. The results are compared to previous results obtained by other methods.

Improvements to the Chebyshev expansion of attenuation correction factors for cylindrical samples

International Nuclear Information System (INIS)

Mildner, D.F.R.; Carpenter, J.M.

1990-01-01

The accuracy of the Chebyshev expansion coefficients used for the calculation of attenuation correction factors for cylinderical samples has been improved. An increased order of expansion allows the method to be useful over a greater range of attenuation. It is shown that many of these coefficients are exactly zero, others are rational numbers, and others are rational frations of π -1 . The assumptions of Sears in his asymptotic expression of the attenuation correction factor are also examined. (orig.)

The effect of correction factors on internal bremsstrahlung spectrum

International Nuclear Information System (INIS)

Elias, M.M.

1985-01-01

Correction factors affecting the experimental spectrum of internal bremsstrahlung (IB) accompanying B-decay have been studied. A wide survey of previous experimental studies, show a discrepancy between experimental results and the available theories of IB production especially for heavy nuclides and forbidden B-transitions, with some agreement in bounded regions in IB spectrum. This is due to the uncertainity in evaluating correction factors and neglecting others. The experimental distributions of IB from 147 Pm, 204 Tl and 90 Y are measured by using two different crystals of NaI(Tl) scintillators (2''x2'' and 3'''x3'') with suitable geometrical arrangements designed to minimize the effect of several factors. The present study covers overlapped ranges of energy from 0.05 to 2.2 MeV to observe the effect of these factors along this wide region of energy. The experimental probabilities are compared with theories. It agrees fairly well with Lewis and Ford theory in case of 14 '7Pm, 204 Tl, and with detour transitions theory in the intermediate region of energies of IB spectrum from 90 Y. Deviation of our results from theories is less than all previous experimental work. 20 tabs.; 43 figs.; 84 refs.; 5 apps

SU-E-T-552: Monte Carlo Calculation of Correction Factors for a Free-Air Ionization Chamber in Support of a National Air-Kerma Standard for Electronic Brachytherapy

Energy Technology Data Exchange (ETDEWEB)

Mille, M; Bergstrom, P [National Institute of Standards and Technology, Gaithersburg, MD (United States)

2015-06-15

Purpose: To use Monte Carlo radiation transport methods to calculate correction factors for a free-air ionization chamber in support of a national air-kerma standard for low-energy, miniature x-ray sources used for electronic brachytherapy (eBx). Methods: The NIST is establishing a calibration service for well-type ionization chambers used to characterize the strength of eBx sources prior to clinical use. The calibration approach involves establishing the well-chamber’s response to an eBx source whose air-kerma rate at a 50 cm distance is determined through a primary measurement performed using the Lamperti free-air ionization chamber. However, the free-air chamber measurements of charge or current can only be related to the reference air-kerma standard after applying several corrections, some of which are best determined via Monte Carlo simulation. To this end, a detailed geometric model of the Lamperti chamber was developed in the EGSnrc code based on the engineering drawings of the instrument. The egs-fac user code in EGSnrc was then used to calculate energy-dependent correction factors which account for missing or undesired ionization arising from effects such as: (1) attenuation and scatter of the x-rays in air; (2) primary electrons escaping the charge collection region; (3) lack of charged particle equilibrium; (4) atomic fluorescence and bremsstrahlung radiation. Results: Energy-dependent correction factors were calculated assuming a monoenergetic point source with the photon energy ranging from 2 keV to 60 keV in 2 keV increments. Sufficient photon histories were simulated so that the Monte Carlo statistical uncertainty of the correction factors was less than 0.01%. The correction factors for a specific eBx source will be determined by integrating these tabulated results over its measured x-ray spectrum. Conclusion: The correction factors calculated in this work are important for establishing a national standard for eBx which will help ensure that dose

Monte Carlo correction factors for a Farmer 0.6 cm3 ion chamber dose measurement in the build-up region of the 6 MV clinical beam

International Nuclear Information System (INIS)

Pena, J; Sanchez-Doblado, F; Capote, R; Terron, J A; Gomez, F

2006-01-01

Reference dosimetry of photon fields is a well-established subject and currently available protocols (such as the IAEA TRS-398 and AAPM TG-51) provide methods for converting the ionization chamber (IC) reading into dose to water, provided reference conditions of charged particle equilibrium (CPE) are fulfilled. But these protocols cannot deal with the build-up region, where the lack of CPE limits the applicability of the cavity theorems and so the chamber correction factors become depth dependent. By explicitly including the IC geometry in the Monte Carlo simulations, depth-dependent dose correction factors are calculated for a PTW 30001 0.6 cm 3 ion chamber in the build-up region of the 6 MV photon beam. The corrected percentage depth dose (PDD) agrees within 2% with that measured using the NACP 02 plane-parallel ion chamber in the build-up region at depths greater than 0.4 cm, where the Farmer chamber wall reaches the phantom surface

Nonnegative Matrix Factor 2-D Deconvolution for Blind Single Channel Source Separation

DEFF Research Database (Denmark)

Schmidt, Mikkel N.; Mørup, Morten

2006-01-01

We present a novel method for blind separation of instruments in polyphonic music based on a non-negative matrix factor 2-D deconvolution algorithm. Using a model which is convolutive in both time and frequency we factorize a spectrogram representation of music into components corresponding...

Correction of a Depth-Dependent Lateral Distortion in 3D Super-Resolution Imaging.

Directory of Open Access Journals (Sweden)

Lina Carlini

Full Text Available Three-dimensional (3D localization-based super-resolution microscopy (SR requires correction of aberrations to accurately represent 3D structure. Here we show how a depth-dependent lateral shift in the apparent position of a fluorescent point source, which we term `wobble`, results in warped 3D SR images and provide a software tool to correct this distortion. This system-specific, lateral shift is typically > 80 nm across an axial range of ~ 1 μm. A theoretical analysis based on phase retrieval data from our microscope suggests that the wobble is caused by non-rotationally symmetric phase and amplitude aberrations in the microscope's pupil function. We then apply our correction to the bacterial cytoskeletal protein FtsZ in live bacteria and demonstrate that the corrected data more accurately represent the true shape of this vertically-oriented ring-like structure. We also include this correction method in a registration procedure for dual-color, 3D SR data and show that it improves target registration error (TRE at the axial limits over an imaging depth of 1 μm, yielding TRE values of < 20 nm. This work highlights the importance of correcting aberrations in 3D SR to achieve high fidelity between the measurements and the sample.

Human aqueous humor levels of transforming growth factor-β2: Association with matrix metalloproteinases/tissue inhibitors of matrix metalloproteinases

OpenAIRE

Jia, Yan; Yue, Yu; Hu, Dan-Ning; Chen, Ji-Li; Zhou, Ji-Bo

2017-01-01

The present study aims to investigate the association of transforming growth factor-β2 (TGF-β2) and matrix metalloproteinases (MMPs), MMP-2 and MMP-3, and tissue inhibitors of matrix metalloproteinases (TIMPs), TIMP-1, TIMP-2 and TIMP-3 in the aqueous humor of patients with high myopia or cataracts. The levels of TGF-β2 and MMPs/TIMPs were measured with the Luminex xMAP Technology using commercially available Milliplex xMAP kits. The association between TGF-β2 and MMPs/TIMPs levels was analyz...

Convex Banding of the Covariance Matrix.

Science.gov (United States)

Bien, Jacob; Bunea, Florentina; Xiao, Luo

2016-01-01

We introduce a new sparse estimator of the covariance matrix for high-dimensional models in which the variables have a known ordering. Our estimator, which is the solution to a convex optimization problem, is equivalently expressed as an estimator which tapers the sample covariance matrix by a Toeplitz, sparsely-banded, data-adaptive matrix. As a result of this adaptivity, the convex banding estimator enjoys theoretical optimality properties not attained by previous banding or tapered estimators. In particular, our convex banding estimator is minimax rate adaptive in Frobenius and operator norms, up to log factors, over commonly-studied classes of covariance matrices, and over more general classes. Furthermore, it correctly recovers the bandwidth when the true covariance is exactly banded. Our convex formulation admits a simple and efficient algorithm. Empirical studies demonstrate its practical effectiveness and illustrate that our exactly-banded estimator works well even when the true covariance matrix is only close to a banded matrix, confirming our theoretical results. Our method compares favorably with all existing methods, in terms of accuracy and speed. We illustrate the practical merits of the convex banding estimator by showing that it can be used to improve the performance of discriminant analysis for classifying sound recordings.

Power Factor Correction for Thyristor Equipment in Glass Industry ...

African Journals Online (AJOL)

Thyristor power controllers are now widely used in the glass industry for controlling furnace temperature. While offering a number of operational advantages, they operate at lagging power factors which require correction for minimum power cost. Harmonic resonance with the utility feed, however, complicate the use of ...

Semi-empirical γ-ray peak efficiency determination including self-absorption correction based on numerical integration

International Nuclear Information System (INIS)

Noguchi, M.; Takeda, K.; Higuchi, H.

1981-01-01

A method of γ-ray efficiency determination for extended (plane or bulk) samples based on numerical integration of point source efficiency is studied. The proposed method is widely applicable to samples of various shapes and materials. The geometrical factor in the peak efficiency can easily be corrected for by simply changing the integration region, and γ-ray self-absorption is also corrected by the absorption coefficients for the sample matrix. (author)

Relationship between γ detection dead-time and count correction factor

International Nuclear Information System (INIS)

Wu Huailong; Zhang Jianhua; Chu Chengsheng; Hu Guangchun; Zhang Changfan; Hu Gen; Gong Jian; Tian Dongfeng

2015-01-01

The relationship between dead-time and count correction factor was investigated by using interference source for purpose of high γ activity measurement. The count rates maintain several 10 s"-"l with γ energy of 0.3-1.3 MeV for 10"4-10"5 Bq radioactive source. It is proved that the relationship between count loss and dead-time is unconcerned at various energy and various count intensities. The same correction formula can be used for any nuclide measurement. (authors)

Monte Carlo study of correction factors for the use of plastic phantoms in clinical electron dosimetry

International Nuclear Information System (INIS)

Araki, Fujio

2007-01-01

In some recent dosimetry protocols, plastic is allowed as a phantom material for the determination of an absorbed dose to water in electron beams, especially for low energy with beam qualities R 50 2 . In electron dosimetry with plastic, a depth-scaling factor, c pl , and a chamber-dependent fluence correction factor, h pl , are needed to convert the dose measured at a water-equivalent reference depth in plastic to a dose at a reference depth in water. The purpose of this study is to calculate correction factors for the use of plastic phantoms for clinical electron dosimetry using the EGSnrc Monte Carlo code system. RMI-457 and WE-211 were investigated as phantom materials. First the c pl values for plastic materials were calculated as a function of a half-value depth of maximum ionization, I 50 , in plastic. The c pl values for RMI-457 and WE-211 varied from 0.992 to 1.002 and from 0.971 to 0.979, respectively, in a range of nominal energies from 4 MeV to 18 MeV, and varied slightly as a function of I 50 in plastic. Since h pl values depend on the wall correction factor, P wall , of the chamber used, they are evaluated using a pure electron fluence correction factor, φ pl w , and P wall w and P wall pl for a combination of water or plastic phantoms and plane-parallel ionization chambers (NACP-02, Markus and Roos). The φ pl w and P wall (P wall w and P wall pl ) values were calculated as a function of the water-equivalent depth in plastic materials and at a reference depth as a function of R 50 in water, respectively. The φ pl w values varied from 1.024 at 4 MeV to 1.013 at 18 MeV for RMI-457, and from 1.025 to 1.016 for WE-211. P wall w values for plane-parallel chambers showed values in the order of 1.5% to 2% larger than unity at 4 MeV, consistent with earlier results. The P wall pl values of RMI-457 and WE-211 were close to unity for all the energy beams. Finally, calculated h pl values of RMI-457 ranged from 1.009 to 1.005, from 1.010 to 1.003 and from 1

Determination of true coincidence correction factors using Monte-Carlo simulation techniques

Directory of Open Access Journals (Sweden)

Chionis Dionysios A.

2014-01-01

Full Text Available Aim of this work is the numerical calculation of the true coincidence correction factors by means of Monte-Carlo simulation techniques. For this purpose, the Monte Carlo computer code PENELOPE was used and the main program PENMAIN was properly modified in order to include the effect of the true coincidence phenomenon. The modified main program that takes into consideration the true coincidence phenomenon was used for the full energy peak efficiency determination of an XtRa Ge detector with relative efficiency 104% and the results obtained for the 1173 keV and 1332 keV photons of 60Co were found consistent with respective experimental ones. The true coincidence correction factors were calculated as the ratio of the full energy peak efficiencies was determined from the original main program PENMAIN and the modified main program PENMAIN. The developed technique was applied for 57Co, 88Y, and 134Cs and for two source-to-detector geometries. The results obtained were compared with true coincidence correction factors calculated from the "TrueCoinc" program and the relative bias was found to be less than 2%, 4%, and 8% for 57Co, 88Y, and 134Cs, respectively.

The Exopolysaccharide Matrix

Science.gov (United States)

Koo, H.; Falsetta, M.L.; Klein, M.I.

2013-01-01

Many infectious diseases in humans are caused or exacerbated by biofilms. Dental caries is a prime example of a biofilm-dependent disease, resulting from interactions of microorganisms, host factors, and diet (sugars), which modulate the dynamic formation of biofilms on tooth surfaces. All biofilms have a microbial-derived extracellular matrix as an essential constituent. The exopolysaccharides formed through interactions between sucrose- (and starch-) and Streptococcus mutans-derived exoenzymes present in the pellicle and on microbial surfaces (including non-mutans) provide binding sites for cariogenic and other organisms. The polymers formed in situ enmesh the microorganisms while forming a matrix facilitating the assembly of three-dimensional (3D) multicellular structures that encompass a series of microenvironments and are firmly attached to teeth. The metabolic activity of microbes embedded in this exopolysaccharide-rich and diffusion-limiting matrix leads to acidification of the milieu and, eventually, acid-dissolution of enamel. Here, we discuss recent advances concerning spatio-temporal development of the exopolysaccharide matrix and its essential role in the pathogenesis of dental caries. We focus on how the matrix serves as a 3D scaffold for biofilm assembly while creating spatial heterogeneities and low-pH microenvironments/niches. Further understanding on how the matrix modulates microbial activity and virulence expression could lead to new approaches to control cariogenic biofilms. PMID:24045647

Relativistic and QED corrections to the g factor of Li-like ions

International Nuclear Information System (INIS)

Glazov, D.A.; Shabaev, V.M.; Volotka, A.V.; Tupitsyn, I.I.; Yerokhin, V.A.; Plunien, G.; Soff, G.

2004-01-01

Calculations of various corrections to the g factor of Li-like ions are presented, which result in a significant improvement of the theoretical accuracy in the region Z=6-92. The configuration-interaction Dirac-Fock method is employed for the evaluation of the interelectronic-interaction correction of order 1/Z 2 and higher. This correction is combined with the 1/Z interelectronic-interaction term derived within a rigorous QED approach. The one-electron QED correction of first order in α is obtained by employing our recent results for the self-energy term and by evaluating the vacuum-polarization contribution. The screening of QED corrections is taken into account to the leading orders in αZ and 1/Z

Age-related collagen turnover of the interstitial matrix and basement membrane: Implications of age- and sex-dependent remodeling of the extracellular matrix

DEFF Research Database (Denmark)

Kehlet, Stephanie N.; Willumsen, Nicholas; Armbrecht, Gabriele

2018-01-01

The extracellular matrix (ECM) plays a vital role in maintaining normal tissue function. Collagens are major components of the ECM and there is a tight equilibrium between degradation and formation of these proteins ensuring tissue health and homeostasis. As a consequence of tissue turnover, small...... collagen fragments are released into the circulation, which act as important biomarkers in the study of certain tissue-related remodeling factors in health and disease. The aim of this study was to establish an age-related collagen turnover profile of the main collagens of the interstitial matrix (type I...... an increased turnover. In summary, collagen turnover is affected by age and sex with the interstitial matrix and the basement membrane being differently regulated. The observed changes needs to be accounted for when measuring ECM related biomarkers in clinical studies....

Improved scatter correction with factor analysis for planar and SPECT imaging

Science.gov (United States)

Knoll, Peter; Rahmim, Arman; Gültekin, Selma; Šámal, Martin; Ljungberg, Michael; Mirzaei, Siroos; Segars, Paul; Szczupak, Boguslaw

2017-09-01

Quantitative nuclear medicine imaging is an increasingly important frontier. In order to achieve quantitative imaging, various interactions of photons with matter have to be modeled and compensated. Although correction for photon attenuation has been addressed by including x-ray CT scans (accurate), correction for Compton scatter remains an open issue. The inclusion of scattered photons within the energy window used for planar or SPECT data acquisition decreases the contrast of the image. While a number of methods for scatter correction have been proposed in the past, in this work, we propose and assess a novel, user-independent framework applying factor analysis (FA). Extensive Monte Carlo simulations for planar and tomographic imaging were performed using the SIMIND software. Furthermore, planar acquisition of two Petri dishes filled with 99mTc solutions and a Jaszczak phantom study (Data Spectrum Corporation, Durham, NC, USA) using a dual head gamma camera were performed. In order to use FA for scatter correction, we subdivided the applied energy window into a number of sub-windows, serving as input data. FA results in two factor images (photo-peak, scatter) and two corresponding factor curves (energy spectra). Planar and tomographic Jaszczak phantom gamma camera measurements were recorded. The tomographic data (simulations and measurements) were processed for each angular position resulting in a photo-peak and a scatter data set. The reconstructed transaxial slices of the Jaszczak phantom were quantified using an ImageJ plugin. The data obtained by FA showed good agreement with the energy spectra, photo-peak, and scatter images obtained in all Monte Carlo simulated data sets. For comparison, the standard dual-energy window (DEW) approach was additionally applied for scatter correction. FA in comparison with the DEW method results in significant improvements in image accuracy for both planar and tomographic data sets. FA can be used as a user

SU-F-T-67: Correction Factors for Monitor Unit Verification of Clinical Electron Beams

Energy Technology Data Exchange (ETDEWEB)

Haywood, J [Mercy Health Partners, Muskegon, MI (United States)

2016-06-15

Purpose: Monitor units calculated by electron Monte Carlo treatment planning systems are often higher than TG-71 hand calculations for a majority of patients. Here I’ve calculated tables of geometry and heterogeneity correction factors for correcting electron hand calculations. Method: A flat water phantom with spherical volumes having radii ranging from 3 to 15 cm was created. The spheres were centered with respect to the flat water phantom, and all shapes shared a surface at 100 cm SSD. D{sub max} dose at 100 cm SSD was calculated for each cone and energy on the flat phantom and for the spherical volumes in the absence of the flat phantom. The ratio of dose in the sphere to dose in the flat phantom defined the geometrical correction factor. The heterogeneity factors were then calculated from the unrestricted collisional stopping power for tissues encountered in electron beam treatments. These factors were then used in patient second check calculations. Patient curvature was estimated by the largest sphere that aligns to the patient contour, and appropriate tissue density was read from the physical properties provided by the CT. The resulting MU were compared to those calculated by the treatment planning system and TG-71 hand calculations. Results: The geometry and heterogeneity correction factors range from ∼(0.8–1.0) and ∼(0.9–1.01) respectively for the energies and cones presented. Percent differences for TG-71 hand calculations drop from ∼(3–14)% to ∼(0–2)%. Conclusion: Monitor units calculated with the correction factors typically decrease the percent difference to under actionable levels, < 5%. While these correction factors work for a majority of patients, there are some patient anatomies that do not fit the assumptions made. Using these factors in hand calculations is a first step in bringing the verification monitor units into agreement with the treatment planning system MU.

Neutron activation analysis of copper traces: a study for sodium correction factor

International Nuclear Information System (INIS)

Tripathi, A.B.R.; Bhadkambekar, C.A.; Basu, A.K.; Chattopadhyay, N.

2007-01-01

Peak ratio correction factors for accurate quantitative determination of copper by NAA via 64 Cu radioisotope in presence of high 24 Na radioactivities has been established. Copper is the principal element as a marker of bullet residues on targets in connection to forensic ballistics cases. Reliable and precise estimation of copper by NAA either via non-destructive way or by resorting to radiochemical separation is of importance in forensic analysis for arriving at definitive inferences. However, majority of samples originating from wearing apparels, paper, leather, skin, glass or any other metal exhibit matrices contain high levels of sodium. The NAA scheme for determination of copper rests on measurements of net counts at 511 KeV which is the positron annihilation peak of 64 Cu. 24 Na also contributes significantly exactly at 511 KeV of gamma energy albeit by different mechanism i.e., by pair production. Therefore, total signal at 511 KeV is contributed by both. The easiest approach for correct estimation of copper traces has been established by the peak ratio correction factor. This has significance as both 64 Cu and 24 Na have comparable half lives, hence, as such time gap measurements cannot improve the situation. The consistency of peak ratio correction factor could be established for a particular geometry. (author)

Factors influencing workplace violence risk among correctional health workers: insights from an Australian survey.

Science.gov (United States)

Cashmore, Aaron W; Indig, Devon; Hampton, Stephen E; Hegney, Desley G; Jalaludin, Bin B

2016-11-01

Little is known about the environmental and organisational determinants of workplace violence in correctional health settings. This paper describes the views of health professionals working in these settings on the factors influencing workplace violence risk. All employees of a large correctional health service in New South Wales, Australia, were invited to complete an online survey. The survey included an open-ended question seeking the views of participants about the factors influencing workplace violence in correctional health settings. Responses to this question were analysed using qualitative thematic analysis. Participants identified several factors that they felt reduced the risk of violence in their workplace, including: appropriate workplace health and safety policies and procedures; professionalism among health staff; the presence of prison guards and the quality of security provided; and physical barriers within clinics. Conversely, participants perceived workplace violence risk to be increased by: low health staff-to-patient and correctional officer-to-patient ratios; high workloads; insufficient or underperforming security staff; and poor management of violence, especially horizontal violence. The views of these participants should inform efforts to prevent workplace violence among correctional health professionals.

Matrix and position correction of shuffler assays by application of the alternating conditional expectation algorithm to shuffler data

International Nuclear Information System (INIS)

Pickrell, M.M.; Rinard, P.M.

1992-01-01

The 252 Cf shuffler assays fissile uranium and plutonium using active neutron interrogation and then counting the induced delayed neutrons. Using the shuffler, we conducted over 1700 assays of 55-gal. drums with 28 different matrices and several different fissionable materials. We measured the drums to dispose the matrix and position effects on 252 Cf shuffler assays. We used several neutron flux monitors during irradiation and kept statistics on the count rates of individual detector banks. The intent of these measurements was to gauge the effect of the matrix independently from the uranium assay. Although shufflers have previously been equipped neutron monitors, the functional relationship between the flux monitor sepals and the matrix-induced perturbation has been unknown. There are several flux monitors so the problem is multivariate, and the response is complicated. Conventional regression techniques cannot address complicated multivariate problems unless the underlying functional form and approximate parameter values are known in advance. Neither was available in this case. To address this problem, we used a new technique called alternating conditional expectations (ACE), which requires neither the functional relationship nor the initial parameters. The ACE algorithm develops the functional form and performs a numerical regression from only the empirical data. We applied the ACE algorithm to the shuffler-assay and flux-monitor data and developed an analytic function for the matrix correction. This function was optimized using conventional multivariate techniques. We were able to reduce the matrix-induced-bias error for homogeneous samples to 12.7%. The bias error for inhomogeneous samples was reduced to 13.5%. These results used only a few adjustable parameters compared to the number of available data points; the data were not ''over fit,'' but rather the results are general and robust

Genetic Algorithm and Graph Theory Based Matrix Factorization Method for Online Friend Recommendation

Directory of Open Access Journals (Sweden)

Qu Li

2014-01-01

Full Text Available Online friend recommendation is a fast developing topic in web mining. In this paper, we used SVD matrix factorization to model user and item feature vector and used stochastic gradient descent to amend parameter and improve accuracy. To tackle cold start problem and data sparsity, we used KNN model to influence user feature vector. At the same time, we used graph theory to partition communities with fairly low time and space complexity. What is more, matrix factorization can combine online and offline recommendation. Experiments showed that the hybrid recommendation algorithm is able to recommend online friends with good accuracy.

Dependence of CIT [Compact Ignition Tokamak] PF [poloidal field] coil currents on profile and shape parameters using the Control Matrix

International Nuclear Information System (INIS)

Strickler, D.J.; Peng, Y-K.M.; Jardin, S.C.; Pomphrey, N.

1990-01-01

The plasma shaping flexibility of the Compact Ignition Tokamak (CIT) poloidal field (PF) coil set is demonstrated through MHD equilibrium calculations of optimal PF coil current distributions and their variation with poloidal beta, internal inductance, plasma 95% elongation, and 95% triangularity. Calculations of the magnetic stored energy are used to compare solutions associated with various plasma parameters. The Control Matrix (CM) equilibrium code, together with the nonlinear equation and numerical optimization software packages HYBRD, and VMCON, respectively, are used to find equilibrium coil current distributions for fixed divertor geometry, volt-seconds, and plasma profiles in order to isolate the dependence on individual parameters. A reference equilibrium and coil current distribution are chosen, and correction currents dI are determined using the CM equilibrium method to obtain other specified plasma shapes. The reference equilibrium is the κ = 2 divertor at beginning of flattop (BOFT) with a minimum stored energy solution for the coil current distribution. The pressure profile function is fixed

Self-Excited Single-Stage Power Factor Correction Driving Circuit for LED Lighting

Directory of Open Access Journals (Sweden)

Yong-Nong Chang

2014-01-01

Full Text Available This pa\tper proposes a self-excited single-stage high power factor LED lighting driving circuit. Being featured with power factor correction capability without needing any control devices, the proposed circuit structure is with low cost and suitable for commercial production. The power factor correction function is accomplished by using inductor in combination with a half-bridge quasi resonant converter to achieve active switching and yield out voltage regulation according to load requirement. Furthermore, the zero-voltage switching in the half-bridge converter can be attained to promote the overall performance efficiency of the proposed circuit. Finally, the validity and production availability of the proposed circuit will be verified as well.

Regulation of proliferation of embryonic heart mesenchyme: Role of transforming growth factor-beta 1 and the interstitial matrix

International Nuclear Information System (INIS)

Choy, M.; Armstrong, M.T.; Armstrong, P.B.

1990-01-01

Proliferation of atrioventricular cushion mesenchyme of the embryonic avian heart maintained in three-dimensional aggregate culture is stimulated by interaction with the interstitial matrix. Chicken serum or transforming growth factor-beta 1, which stimulates proliferation, induces matrix deposition in regions of the aggregate showing high labeling indices with tritiated thymidine. Dispersed heart mesenchyme interstitial matrix introduced into serum-free culture is incorporated into the aggregate and stimulates cellular proliferation similar to serum or transforming growth factor-beta 1. Proliferation is reversibly inhibited by the peptide Gly-Arg-Gly-Asp-Ser-Pro. It is suggested that transforming growth factor-beta 1 stimulates the production of interstitial matrix and that a sufficient stimulus for proliferation in this system is the presence of the matrix, which acts as the adhesive support for cellular anchorage

Matrix Metalloproteinases in Non-Neoplastic Disorders

Science.gov (United States)

Tokito, Akinori; Jougasaki, Michihisa

2016-01-01

The matrix metalloproteinases (MMPs) are zinc-dependent endopeptidases belonging to the metzincin superfamily. There are at least 23 members of MMPs ever reported in human, and they and their substrates are widely expressed in many tissues. Recent growing evidence has established that MMP not only can degrade a variety of components of extracellular matrix, but also can cleave and activate various non-matrix proteins, including cytokines, chemokines and growth factors, contributing to both physiological and pathological processes. In normal conditions, MMP expression and activity are tightly regulated via interactions between their activators and inhibitors. Imbalance among these factors, however, results in dysregulated MMP activity, which causes tissue destruction and functional alteration or local inflammation, leading to the development of diverse diseases, such as cardiovascular disease, arthritis, neurodegenerative disease, as well as cancer. This article focuses on the accumulated evidence supporting a wide range of roles of MMPs in various non-neoplastic diseases and provides an outlook on the therapeutic potential of inhibiting MMP action. PMID:27455234

Analysis and correction of gradient nonlinearity bias in apparent diffusion coefficient measurements.

Science.gov (United States)

Malyarenko, Dariya I; Ross, Brian D; Chenevert, Thomas L

2014-03-01

Gradient nonlinearity of MRI systems leads to spatially dependent b-values and consequently high non-uniformity errors (10-20%) in apparent diffusion coefficient (ADC) measurements over clinically relevant field-of-views. This work seeks practical correction procedure that effectively reduces observed ADC bias for media of arbitrary anisotropy in the fewest measurements. All-inclusive bias analysis considers spatial and time-domain cross-terms for diffusion and imaging gradients. The proposed correction is based on rotation of the gradient nonlinearity tensor into the diffusion gradient frame where spatial bias of b-matrix can be approximated by its Euclidean norm. Correction efficiency of the proposed procedure is numerically evaluated for a range of model diffusion tensor anisotropies and orientations. Spatial dependence of nonlinearity correction terms accounts for the bulk (75-95%) of ADC bias for FA = 0.3-0.9. Residual ADC non-uniformity errors are amplified for anisotropic diffusion. This approximation obviates need for full diffusion tensor measurement and diagonalization to derive a corrected ADC. Practical scenarios are outlined for implementation of the correction on clinical MRI systems. The proposed simplified correction algorithm appears sufficient to control ADC non-uniformity errors in clinical studies using three orthogonal diffusion measurements. The most efficient reduction of ADC bias for anisotropic medium is achieved with non-lab-based diffusion gradients. Copyright © 2013 Wiley Periodicals, Inc.

Impact of hadronic and nuclear corrections on global analysis of spin-dependent parton distributions

Energy Technology Data Exchange (ETDEWEB)

Jimenez-Delgado, Pedro [Thomas Jefferson National Accelerator Facility, Newport News, VA (United States); Accardi, Alberto [Hampton University, Hampton, VA (United States); Thomas Jefferson National Accelerator Facility, Newport News, VA (United States); Melnitchouk, Wally [Thomas Jefferson National Accelerator Facility, Newport News, VA (United States)

2014-02-01

We present the first results of a new global next-to-leading order analysis of spin-dependent parton distribution functions from the most recent world data on inclusive polarized deep-inelastic scattering, focusing in particular on the large-x and low-Q^2 regions. By directly fitting polarization asymmetries we eliminate biases introduced by using polarized structure function data extracted under nonuniform assumptions for the unpolarized structure functions. For analysis of the large-x data we implement nuclear smearing corrections for deuterium and 3He nuclei, and systematically include target mass and higher twist corrections to the g_1 and g_2 structure functions at low Q^2. We also explore the effects of Q^2 and W^2 cuts in the data sets, and the potential impact of future data on the behavior of the spin-dependent parton distributions at large x.

A proposed parameterization of interface discontinuity factors depending on neighborhood for pin-by-pin diffusion computations for LWR

International Nuclear Information System (INIS)

Herrero, Jose Javier; Garcia-Herranz, Nuria; Ahnert, Carol

2011-01-01

There exists an interest in performing full core pin-by-pin computations for present nuclear reactors. In such type of problems the use of a transport approximation like the diffusion equation requires the introduction of correction parameters. Interface discontinuity factors can improve the diffusion solution to nearly reproduce a transport solution. Nevertheless, calculating accurate pin-by-pin IDF requires the knowledge of the heterogeneous neutron flux distribution, which depends on the boundary conditions of the pin-cell as well as the local variables along the nuclear reactor operation. As a consequence, it is impractical to compute them for each possible configuration. An alternative to generate accurate pin-by-pin interface discontinuity factors is to calculate reference values using zero-net-current boundary conditions and to synthesize afterwards their dependencies on the main neighborhood variables. In such way the factors can be accurately computed during fine-mesh diffusion calculations by correcting the reference values as a function of the actual environment of the pin-cell in the core. In this paper we propose a parameterization of the pin-by-pin interface discontinuity factors allowing the implementation of a cross sections library able to treat the neighborhood effect. First results are presented for typical PWR configurations. (author)

A proposed parameterization of interface discontinuity factors depending on neighborhood for pin-by-pin diffusion computations for LWR

Energy Technology Data Exchange (ETDEWEB)

Herrero, Jose Javier; Garcia-Herranz, Nuria; Ahnert, Carol, E-mail: herrero@din.upm.es, E-mail: nuria@din.upm.es, E-mail: carol@din.upm.es [Departamento de Ingenieria Nuclear, Universidad Politecnica de Madrid (Spain)

2011-07-01

There exists an interest in performing full core pin-by-pin computations for present nuclear reactors. In such type of problems the use of a transport approximation like the diffusion equation requires the introduction of correction parameters. Interface discontinuity factors can improve the diffusion solution to nearly reproduce a transport solution. Nevertheless, calculating accurate pin-by-pin IDF requires the knowledge of the heterogeneous neutron flux distribution, which depends on the boundary conditions of the pin-cell as well as the local variables along the nuclear reactor operation. As a consequence, it is impractical to compute them for each possible configuration. An alternative to generate accurate pin-by-pin interface discontinuity factors is to calculate reference values using zero-net-current boundary conditions and to synthesize afterwards their dependencies on the main neighborhood variables. In such way the factors can be accurately computed during fine-mesh diffusion calculations by correcting the reference values as a function of the actual environment of the pin-cell in the core. In this paper we propose a parameterization of the pin-by-pin interface discontinuity factors allowing the implementation of a cross sections library able to treat the neighborhood effect. First results are presented for typical PWR configurations. (author)

RPA correction to the optical potential

Directory of Open Access Journals (Sweden)

Bauge E.

2010-03-01

Full Text Available In studies of nucleon elastic scattering, a correction to the microscopic optical potential built from Melbourne g-matrix was found to be necessary at low nucleon incident energy [1,2]. Indeed, at energies lower than 60 MeV, the absorption generated from Melbourne g-matrix is too weak within 25%. Coupling to collective excited states of the target nucleus are not included in the g-matrix and could explain the missing absorption. We propose to calculate this correction to the optical potential using the Gogny D1S effective nucleon-nucleon interaction in the coupling to excited states of the target. We use the Random Phase Approximation (RPA description of the excited states of the target with the same interaction.

Stray light correction on array spectroradiometers for optical radiation risk assessment in the workplace

International Nuclear Information System (INIS)

Barlier-Salsi, A

2014-01-01

The European directive 2006/25/EC requires the employer to assess and, if necessary, measure the levels of exposure to optical radiation in the workplace. Array spectroradiometers can measure optical radiation from various types of sources; however poor stray light rejection affects their accuracy. A stray light correction matrix, using a tunable laser, was developed at the National Institute of Standards and Technology (NIST). As tunable lasers are very expensive, the purpose of this study was to implement this method using only nine low power lasers; other elements of the correction matrix being completed by interpolation and extrapolation. The correction efficiency was evaluated by comparing CCD spectroradiometers with and without correction and a scanning double monochromator device as reference. Similar to findings recorded by NIST, these experiments show that it is possible to reduce the spectral stray light by one or two orders of magnitude. In terms of workplace risk assessment, this spectral stray light correction method helps determine exposure levels, with an acceptable degree of uncertainty, for the majority of workplace situations. The level of uncertainty depends upon the model of spectroradiometers used; the best results are obtained with CCD detectors having an enhanced spectral sensitivity in the UV range. Thus corrected spectroradiometers require a validation against a scanning double monochromator spectroradiometer before using them for risk assessment in the workplace. (paper)

Stray light correction on array spectroradiometers for optical radiation risk assessment in the workplace.

Science.gov (United States)

Barlier-Salsi, A

2014-12-01

The European directive 2006/25/EC requires the employer to assess and, if necessary, measure the levels of exposure to optical radiation in the workplace. Array spectroradiometers can measure optical radiation from various types of sources; however poor stray light rejection affects their accuracy. A stray light correction matrix, using a tunable laser, was developed at the National Institute of Standards and Technology (NIST). As tunable lasers are very expensive, the purpose of this study was to implement this method using only nine low power lasers; other elements of the correction matrix being completed by interpolation and extrapolation. The correction efficiency was evaluated by comparing CCD spectroradiometers with and without correction and a scanning double monochromator device as reference. Similar to findings recorded by NIST, these experiments show that it is possible to reduce the spectral stray light by one or two orders of magnitude. In terms of workplace risk assessment, this spectral stray light correction method helps determine exposure levels, with an acceptable degree of uncertainty, for the majority of workplace situations. The level of uncertainty depends upon the model of spectroradiometers used; the best results are obtained with CCD detectors having an enhanced spectral sensitivity in the UV range. Thus corrected spectroradiometers require a validation against a scanning double monochromator spectroradiometer before using them for risk assessment in the workplace.

Contribution of non-negative matrix factorization to the classification of remote sensing images

Science.gov (United States)

Karoui, M. S.; Deville, Y.; Hosseini, S.; Ouamri, A.; Ducrot, D.

2008-10-01

Remote sensing has become an unavoidable tool for better managing our environment, generally by realizing maps of land cover using classification techniques. The classification process requires some pre-processing, especially for data size reduction. The most usual technique is Principal Component Analysis. Another approach consists in regarding each pixel of the multispectral image as a mixture of pure elements contained in the observed area. Using Blind Source Separation (BSS) methods, one can hope to unmix each pixel and to perform the recognition of the classes constituting the observed scene. Our contribution consists in using Non-negative Matrix Factorization (NMF) combined with sparse coding as a solution to BSS, in order to generate new images (which are at least partly separated images) using HRV SPOT images from Oran area, Algeria). These images are then used as inputs of a supervised classifier integrating textural information. The results of classifications of these "separated" images show a clear improvement (correct pixel classification rate improved by more than 20%) compared to classification of initial (i.e. non separated) images. These results show the contribution of NMF as an attractive pre-processing for classification of multispectral remote sensing imagery.

Relativistic corrections to the form factors of Bc into P-wave orbitally excited charmonium

Science.gov (United States)

Zhu, Ruilin

2018-06-01

We investigated the form factors of the Bc meson into P-wave orbitally excited charmonium using the nonrelativistic QCD effective theory. Through the analytic computation, the next-to-leading order relativistic corrections to the form factors were obtained, and the asymptotic expressions were studied in the infinite bottom quark mass limit. Employing the general form factors, we discussed the exclusive decays of the Bc meson into P-wave orbitally excited charmonium and a light meson. We found that the relativistic corrections lead to a large correction for the form factors, which makes the branching ratios of the decay channels B (Bc ± →χcJ (hc) +π± (K±)) larger. These results are useful for the phenomenological analysis of the Bc meson decays into P-wave charmonium, which shall be tested in the LHCb experiments.

Determination of correction factor of radioelement content data generated from Exploranium GR-320 Gamma spectrometer

International Nuclear Information System (INIS)

Nasrun, S; Syamsul-Hadi, M; Sumardi

2000-01-01

Gamma-ray Spectrometer Exploranium GR-320 is the instrument radiometric survey which is able to measure radioelement content directly in field based on partial gamma-ray energy of elements. Because of the instrument is new and it was granted from the lAEA, so it is necessarily to create a correction factor for the instrument due to be gaining the better data. Correction factor was generated from comparing gamma spectrometer's radioelement content to those of chemical analysed data of calibration pad. The correction factor for Potassium (K) is 1.31, uranium is 1.46, and thorium is 0.39

Sequence correction of random coil chemical shifts: correlation between neighbor correction factors and changes in the Ramachandran distribution

DEFF Research Database (Denmark)

Kjærgaard, Magnus; Poulsen, Flemming Martin

2011-01-01

Random coil chemical shifts are necessary for secondary chemical shift analysis, which is the main NMR method for identification of secondary structure in proteins. One of the largest challenges in the determination of random coil chemical shifts is accounting for the effect of neighboring residues....... The contributions from the neighboring residues are typically removed by using neighbor correction factors determined based on each residue's effect on glycine chemical shifts. Due to its unusual conformational freedom, glycine may be particularly unrepresentative for the remaining residue types. In this study, we...... in the conformational ensemble are an important source of neighbor effects in disordered proteins. Glutamine derived random coil chemical shifts and correction factors modestly improve our ability to predict (13)C chemical shifts of intrinsically disordered proteins compared to existing datasets, and may thus improve...

Google matrix and Ulam networks of intermittency maps.

Science.gov (United States)

Ermann, L; Shepelyansky, D L

2010-03-01

We study the properties of the Google matrix of an Ulam network generated by intermittency maps. This network is created by the Ulam method which gives a matrix approximant for the Perron-Frobenius operator of dynamical map. The spectral properties of eigenvalues and eigenvectors of this matrix are analyzed. We show that the PageRank of the system is characterized by a power law decay with the exponent beta dependent on map parameters and the Google damping factor alpha . Under certain conditions the PageRank is completely delocalized so that the Google search in such a situation becomes inefficient.

Deep subcritical levels measurements dependents upon kinetic distortion factors

International Nuclear Information System (INIS)

Pan Shibiao; Li Xiang; Fu Guo'en; Huang Liyuan; Mu Keliang

2013-01-01

The measurement of deep subcritical levels, with the increase of subcriticality, showed that the results impact on the kinetic distortion effect, along with neutron flux strongly deteriorated. Using the diffusion theory, calculations have been carried out to quantify the kinetic distortion correction factors in subcritical systems, and these indicate that epithermal neutron distributions are strongly affected by kinetic distortion. Subcriticality measurements in four different rod-state combination at the zero power device was carried out. The test data analysis shows that, with increasing subcriticality, kinetic distortion effect correction factor gradually increases from 1.052 to 1.065, corresponding reactive correction amount of 0.78β eff ∼ 3.01β eff . Thus, it is necessary to consider the kinetic distortion effect in the deep subcritical reactivity measurements. (authors)

An Extended-Tag-Induced Matrix Factorization Technique for Recommender Systems

Directory of Open Access Journals (Sweden)

Huirui Han

2018-06-01

Full Text Available Social tag information has been used by recommender systems to handle the problem of data sparsity. Recently, the relationships between users/items and tags are considered by most tag-induced recommendation methods. However, sparse tag information is challenging to most existing methods. In this paper, we propose an Extended-Tag-Induced Matrix Factorization technique for recommender systems, which exploits correlations among tags derived by co-occurrence of tags to improve the performance of recommender systems, even in the case of sparse tag information. The proposed method integrates coupled similarity between tags, which is calculated by the co-occurrences of tags in the same items, to extend each item’s tags. Finally, item similarity based on extended tags is utilized as an item relationship regularization term to constrain the process of matrix factorization. MovieLens dataset and Book-Crossing dataset are adopted to evaluate the performance of the proposed algorithm. The results of experiments show that the proposed method can alleviate the impact of tag sparsity and improve the performance of recommender systems.

Using Dynamic Multi-Task Non-Negative Matrix Factorization to Detect the Evolution of User Preferences in Collaborative Filtering.

Directory of Open Access Journals (Sweden)

Bin Ju

Full Text Available Predicting what items will be selected by a target user in the future is an important function for recommendation systems. Matrix factorization techniques have been shown to achieve good performance on temporal rating-type data, but little is known about temporal item selection data. In this paper, we developed a unified model that combines Multi-task Non-negative Matrix Factorization and Linear Dynamical Systems to capture the evolution of user preferences. Specifically, user and item features are projected into latent factor space by factoring co-occurrence matrices into a common basis item-factor matrix and multiple factor-user matrices. Moreover, we represented both within and between relationships of multiple factor-user matrices using a state transition matrix to capture the changes in user preferences over time. The experiments show that our proposed algorithm outperforms the other algorithms on two real datasets, which were extracted from Netflix movies and Last.fm music. Furthermore, our model provides a novel dynamic topic model for tracking the evolution of the behavior of a user over time.

Using Dynamic Multi-Task Non-Negative Matrix Factorization to Detect the Evolution of User Preferences in Collaborative Filtering.

Science.gov (United States)

Ju, Bin; Qian, Yuntao; Ye, Minchao; Ni, Rong; Zhu, Chenxi

2015-01-01

Predicting what items will be selected by a target user in the future is an important function for recommendation systems. Matrix factorization techniques have been shown to achieve good performance on temporal rating-type data, but little is known about temporal item selection data. In this paper, we developed a unified model that combines Multi-task Non-negative Matrix Factorization and Linear Dynamical Systems to capture the evolution of user preferences. Specifically, user and item features are projected into latent factor space by factoring co-occurrence matrices into a common basis item-factor matrix and multiple factor-user matrices. Moreover, we represented both within and between relationships of multiple factor-user matrices using a state transition matrix to capture the changes in user preferences over time. The experiments show that our proposed algorithm outperforms the other algorithms on two real datasets, which were extracted from Netflix movies and Last.fm music. Furthermore, our model provides a novel dynamic topic model for tracking the evolution of the behavior of a user over time.

Transfer matrix in 1D Schroedinger problems with constant and position-dependent mass

International Nuclear Information System (INIS)

Perez-Alvarez, R.; Rodriguez-Coppola, H.

1987-10-01

We consider the transfer matrix method for obtaining properties of standard wells and barriers in one-dimensional Schroedinger problems with constant and position-dependent mass. We report the formulae for the energy levels of a well and the transmission coefficient of a barrier. We demonstrate the continuity between virtual bound states and bound states in a well of position-dependent mass and the relation between the zero energy gap states of a periodic potential problem with the corresponding energies of the non-periodic ones with transmission coefficient equal to one. The calculations were carried out for a wide class of potential profiles. (author). 30 refs, 2 figs

Power correction to the asymptotics of the pion electromagnetic form factor

International Nuclear Information System (INIS)

Geshkenbein, B.V.; Terentyev, M.V.

1982-01-01

The contribution of the power correction approximately (μ 2 /Q 2 ) 2 enhanced by the factor approximately μ 2 /anti m 2 , to the pion form factor (FF) is calculated (here μ is the pion mass, anti m=1/2(msub(u)+msub(α)) is the mean value of the u- and d-quark masses, Q 2 =-(p-p') 2 > 0, where p, p' are meson momenta at initial and final state. It is shown that the only source of large corrections is due to the contribution of the local pseudoscalar current. The main (approximately 1/Q 2 ) asymptotics of FF associated with the axial current contribution, is derived. The contribution (approximately 1/Q 4 ) of the pseudoscalar current is calculated

Ionization chamber correction factors for MR-linacs.

Science.gov (United States)

Pojtinger, Stefan; Dohm, Oliver Steffen; Kapsch, Ralf-Peter; Thorwarth, Daniela

2018-06-07

Previously, readings of air-filled ionization chambers have been described as being influenced by magnetic fields. To use these chambers for dosimetry in magnetic resonance guided radiotherapy (MRgRT), this effect must be taken into account by introducing a correction factor k B . The purpose of this study is to systematically investigate k B for a typical reference setup for commercially available ionization chambers with different magnetic field strengths. The Monte Carlo simulation tool EGSnrc was used to simulate eight commercially available ionization chambers in magnetic fields whose magnetic flux density was in the range of 0-2.5 T. To validate the simulation, the influence of the magnetic field was experimentally determined for a PTW30013 Farmer-type chamber for magnetic flux densities between 0 and 1.425 T. Changes in the detector response of up to 8% depending on the magnetic flux density, on the chamber geometry and on the chamber orientation were obtained. In the experimental setup, a maximum deviation of less than 2% was observed when comparing measured values with simulated values. Dedicated values for two MR-linac systems (ViewRay MRIdian, ViewRay Inc, Cleveland, United States, 0.35 T/ 6 MV and Elekta Unity, Elekta AB, Stockholm, Sweden, 1.5 T/7 MV) were determined for future use in reference dosimetry. Simulated values for thimble-type chambers are in good agreement with experiments as well as with the results of previous publications. After further experimental validation, the results can be considered for definition of standard protocols for purposes of reference dosimetry in MRgRT.

Ionization chamber correction factors for MR-linacs

Science.gov (United States)

Pojtinger, Stefan; Steffen Dohm, Oliver; Kapsch, Ralf-Peter; Thorwarth, Daniela

2018-06-01

Previously, readings of air-filled ionization chambers have been described as being influenced by magnetic fields. To use these chambers for dosimetry in magnetic resonance guided radiotherapy (MRgRT), this effect must be taken into account by introducing a correction factor k B. The purpose of this study is to systematically investigate k B for a typical reference setup for commercially available ionization chambers with different magnetic field strengths. The Monte Carlo simulation tool EGSnrc was used to simulate eight commercially available ionization chambers in magnetic fields whose magnetic flux density was in the range of 0–2.5 T. To validate the simulation, the influence of the magnetic field was experimentally determined for a PTW30013 Farmer-type chamber for magnetic flux densities between 0 and 1.425 T. Changes in the detector response of up to 8% depending on the magnetic flux density, on the chamber geometry and on the chamber orientation were obtained. In the experimental setup, a maximum deviation of less than 2% was observed when comparing measured values with simulated values. Dedicated values for two MR-linac systems (ViewRay MRIdian, ViewRay Inc, Cleveland, United States, 0.35 T/ 6 MV and Elekta Unity, Elekta AB, Stockholm, Sweden, 1.5 T/7 MV) were determined for future use in reference dosimetry. Simulated values for thimble-type chambers are in good agreement with experiments as well as with the results of previous publications. After further experimental validation, the results can be considered for definition of standard protocols for purposes of reference dosimetry in MRgRT.

Compensation of matrix effects in gas chromatography-mass spectrometry analysis of pesticides using a combination of matrix matching and multiple isotopically labeled internal standards.

Science.gov (United States)

Tsuchiyama, Tomoyuki; Katsuhara, Miki; Nakajima, Masahiro

2017-11-17

In the multi-residue analysis of pesticides using GC-MS, the quantitative results are adversely affected by a phenomenon known as the matrix effect. Although the use of matrix-matched standards is considered to be one of the most practical solutions to this problem, complete removal of the matrix effect is difficult in complex food matrices owing to their inconsistency. As a result, residual matrix effects can introduce analytical errors. To compensate for residual matrix effects, we have developed a novel method that employs multiple isotopically labeled internal standards (ILIS). The matrix effects of ILIS and pesticides were evaluated in spiked matrix extracts of various agricultural commodities, and the obtained data were subjected to simple statistical analysis. Based on the similarities between the patterns of variation in the analytical response, a total of 32 isotopically labeled compounds were assigned to 338 pesticides as internal standards. It was found that by utilizing multiple ILIS, residual matrix effects could be effectively compensated. The developed method exhibited superior quantitative performance compared with the common single-internal-standard method. The proposed method is more feasible for regulatory purposes than that using only predetermined correction factors and is considered to be promising for practical applications. Copyright © 2017 Elsevier B.V. All rights reserved.

Development of the Heated Length Correction Factor

International Nuclear Information System (INIS)

Park, Ho-Young; Kim, Kang-Hoon; Nahm, Kee-Yil; Jung, Yil-Sup; Park, Eung-Jun

2008-01-01

The Critical Heat Flux (CHF) on a nuclear fuel is defined by the function of flow channel geometry and flow condition. According to the selection of the explanatory variable, there are three hypotheses to explain CHF at uniformly heated vertical rod (inlet condition hypothesis, exit condition hypothesis, local condition hypothesis). For inlet condition hypothesis, CHF is characterized by function of system pressure, rod diameter, rod length, mass flow and inlet subcooling. For exit condition hypothesis, exit quality substitutes for inlet subcooling. Generally the heated length effect on CHF in exit condition hypothesis is smaller than that of other variables. Heated length is usually excluded in local condition hypothesis to describe the CHF with only local fluid conditions. Most of commercial plants currently use the empirical CHF correlation based on local condition hypothesis. Empirical CHF correlation is developed by the method of fitting the selected sensitive local variables to CHF test data using the multiple non-linear regression. Because this kind of method can not explain physical meaning, it is difficult to reflect the proper effect of complex geometry. So the recent CHF correlation development strategy of nuclear fuel vendor is making the basic CHF correlation which consists of basic flow variables (local fluid conditions) at first, and then the geometrical correction factors are compensated additionally. Because the functional forms of correction factors are determined from the independent test data which represent the corresponding geometry separately, it can be applied to other CHF correlation directly only with minor coefficient modification

Standard model treatment of the radiative corrections to the neutron β-decay

International Nuclear Information System (INIS)

Bunatyan, G.G.

2003-01-01

Starting with the basic Lagrangian of the Standard Model, the radiative corrections to the neutron β-decay are acquired. The electroweak interactions are consistently taken into consideration amenably to the Weinberg-Salam theory. The effect of the strong quark-quark interactions on the neutron β-decay is parametrized by introducing the nucleon electromagnetic form factors and the weak nucleon transition current specified by the form factors g V , g A , ... The radiative corrections to the total decay probability W and to the asymmetry coefficient of the momentum distribution A are obtained to constitute δW ∼ 8.7 %, δA ∼ -2 %. The contribution to the radiative corrections due to allowance for the nucleon form factors and the nucleon excited states amounts up to a few per cent of the whole value of the radiative corrections. The ambiguity in description of the nucleon compositeness is surely what causes the uncertainties ∼ 0.1 % in evaluation of the neutron β-decay characteristics. For now, this puts bounds to the precision attainable in obtaining the element V ud of the CKM matrix and the g V , g A , ... values from experimental data processing

Role of humidity and other correction factors in the AAPM TG-21 dosimetry protocol

International Nuclear Information System (INIS)

Rogers, D.W.; Ross, C.K.

1988-01-01

A detailed derivation is presented of the formulas required to determine Ngas and Dmed in the AAPM TG-21 dosimetry protocol. This protocol specifies how to determine the absorbed dose in an electron or photon beam when using exposure or absorbed dose calibrated ion chambers. It is shown that the expression given in TG-21's recent letter of clarification is incorrect. Accounting for humidity correctly increases, by 0.4%, all absorbed dose determinations using an exposure calibrated ion chamber. Taking into account other correction factors in the equation for exposure could also have varying, but significant effects (possibly over 1%). These are the stem scatter correction, the axial nonuniformity correction and the electrode correction for electrodes made of different materials from the wall. Attention is drawn to differences in the definitions of the exposure and absorbed dose calibration factors, Nx and ND, respectively, as supplied by the NBS and the NRCC

Position Error Covariance Matrix Validation and Correction

Science.gov (United States)

Frisbee, Joe, Jr.

2016-01-01

In order to calculate operationally accurate collision probabilities, the position error covariance matrices predicted at times of closest approach must be sufficiently accurate representations of the position uncertainties. This presentation will discuss why the Gaussian distribution is a reasonable expectation for the position uncertainty and how this assumed distribution type is used in the validation and correction of position error covariance matrices.

Robust Image Regression Based on the Extended Matrix Variate Power Exponential Distribution of Dependent Noise.

Science.gov (United States)

Luo, Lei; Yang, Jian; Qian, Jianjun; Tai, Ying; Lu, Gui-Fu

2017-09-01

Dealing with partial occlusion or illumination is one of the most challenging problems in image representation and classification. In this problem, the characterization of the representation error plays a crucial role. In most current approaches, the error matrix needs to be stretched into a vector and each element is assumed to be independently corrupted. This ignores the dependence between the elements of error. In this paper, it is assumed that the error image caused by partial occlusion or illumination changes is a random matrix variate and follows the extended matrix variate power exponential distribution. This has the heavy tailed regions and can be used to describe a matrix pattern of l×m dimensional observations that are not independent. This paper reveals the essence of the proposed distribution: it actually alleviates the correlations between pixels in an error matrix E and makes E approximately Gaussian. On the basis of this distribution, we derive a Schatten p -norm-based matrix regression model with L q regularization. Alternating direction method of multipliers is applied to solve this model. To get a closed-form solution in each step of the algorithm, two singular value function thresholding operators are introduced. In addition, the extended Schatten p -norm is utilized to characterize the distance between the test samples and classes in the design of the classifier. Extensive experimental results for image reconstruction and classification with structural noise demonstrate that the proposed algorithm works much more robustly than some existing regression-based methods.

Impact of the neutron detector choice on Bell and Glasstone spatial correction factor for subcriticality measurement

Energy Technology Data Exchange (ETDEWEB)

Talamo, Alberto, E-mail: alby@anl.gov [Argonne National Laboratory, 9700S. Cass Avenue, Argonne, IL 60439 (United States); Gohar, Y.; Cao, Y.; Zhong, Z. [Argonne National Laboratory, 9700S. Cass Avenue, Argonne, IL 60439 (United States); Kiyavitskaya, H.; Bournos, V.; Fokov, Y.; Routkovskaya, C. [Joint Institute for Power and Nuclear Research-Sosny, National Academy of Sciences of Belarus, 99 acad. Krasin str., Minsk 220109 (Belarus)

2012-03-11

In subcritical assemblies, the Bell and Glasstone spatial correction factor is used to correct the measured reactivity from different detector positions. In addition to the measuring position, several other parameters affect the correction factor: the detector material, the detector size, and the energy-angle distribution of source neutrons. The effective multiplication factor calculated by computer codes in criticality mode slightly differs from the average value obtained from the measurements in the different experimental channels of the subcritical assembly, which are corrected by the Bell and Glasstone spatial correction factor. Generally, this difference is due to (1) neutron counting errors; (2) geometrical imperfections, which are not simulated in the calculational model, and (3) quantities and distributions of material impurities, which are missing from the material definitions. This work examines these issues and it focuses on the detector choice and the calculation methodologies. The work investigated the YALINA Booster subcritical assembly of Belarus, which has been operated with three different fuel enrichments in the fast zone either: high (90%) and medium (36%), medium (36%), or low (21%) enriched uranium fuel.

Impact of the neutron detector choice on Bell and Glasstone spatial correction factor for subcriticality measurement

International Nuclear Information System (INIS)

Talamo, Alberto; Gohar, Y.; Cao, Y.; Zhong, Z.; Kiyavitskaya, H.; Bournos, V.; Fokov, Y.; Routkovskaya, C.

2012-01-01

In subcritical assemblies, the Bell and Glasstone spatial correction factor is used to correct the measured reactivity from different detector positions. In addition to the measuring position, several other parameters affect the correction factor: the detector material, the detector size, and the energy-angle distribution of source neutrons. The effective multiplication factor calculated by computer codes in criticality mode slightly differs from the average value obtained from the measurements in the different experimental channels of the subcritical assembly, which are corrected by the Bell and Glasstone spatial correction factor. Generally, this difference is due to (1) neutron counting errors; (2) geometrical imperfections, which are not simulated in the calculational model, and (3) quantities and distributions of material impurities, which are missing from the material definitions. This work examines these issues and it focuses on the detector choice and the calculation methodologies. The work investigated the YALINA Booster subcritical assembly of Belarus, which has been operated with three different fuel enrichments in the fast zone either: high (90%) and medium (36%), medium (36%), or low (21%) enriched uranium fuel.

Application of R-Matrix with Time-dependence Theory to Double Ionisation Using a 2-electron Outer Region

International Nuclear Information System (INIS)

Wragg, Jack; Parker, J S; Van der Hart, H W

2015-01-01

R-Matrix with Time-dependence (RMT) theory has been extended to cover double-ionisation processes. An application to photoionisation of He is demonstrated, with an emphasis on double-ionisation cross sections. (paper)

NNLO QCD corrections to the $B\\to X_s \\gamma$ matrix elements using interpolation in $m_c$

CERN Document Server

Misiak, M; Misiak, Mikolaj; Steinhauser, Matthias

2007-01-01

One of the most troublesome contributions to the NNLO QCD corrections to B -> X_s gamma originates from three-loop matrix elements of four-quark operators. A part of this contribution that is proportional to the QCD beta-function coefficient beta_0 was found in 2003 as an expansion in m_c/m_b. In the present paper, we evaluate the asymptotic behaviour of the complete contribution for m_c >> m_b/2. The asymptotic form of the beta_0-part matches the small-m_c expansion very well at the threshold m_c = m_b/2. For the remaining part, we perform an interpolation down to the measured value of m_c, assuming that the beta_0-part is a good approximation at m_c=0. Combining our results with other contributions to the NNLO QCD corrections, we find BR(B -> X_s gamma) = (3.15 +_ 0.23) x 10^-4 for E_gamma > 1.6 GeV in the B-meson rest frame. The indicated error has been obtained by adding in quadrature the following uncertainties: non-perturbative (5%), parametric (3%), higher-order perturbative (3%), and the interpolation...

Advances in orbit drift correction in the advanced photon source storage ring

International Nuclear Information System (INIS)

Emery, L.; Borland, M.

1997-01-01

The Advanced Photon Source storage ring is required to provide X-ray beams of high positional stability, specified as 17 μm rms in the horizontal plane and 4.4 μm rms in the vertical plane. The author reports on the difficult task of stabilizing the slow drift component of the orbit motion down to a few microns rms using workstation-based orbit correction. There are two aspects to consider separately the correction algorithm and the configuration of the beam position monitors (BPMs) and correctors. Three notable features of the correction algorithm are: low-pass digital filtering of BPM readbacks; open-quotes despikingclose quotes of the filtered orbit to desensitize the orbit correction to spurious BPM readbacks without having to change the correction matrix; and BPM intensity-dependent offset compensation. The BPM/corrector configuration includes all of the working BPMs but only a small set of correctors distributed around the ring. Thus only those orbit modes that are most likely to be representative of real beam drift are handled by the correction algorithm

Matching of singly- and doubly-unresolved limits of tree-level QCD squared matrix elements

Energy Technology Data Exchange (ETDEWEB)

Somogyi, Gabor [University of Debrecen and Institute of Nuclear Research of the Hungarian Academy of Sciences, H-4001 Debrecen, PO Box 51 (Hungary); Trocsanyi, Zoltan [University of Debrecen and Institute of Nuclear Research of the Hungarian Academy of Sciences, H-4001 Debrecen, PO Box 51 (Hungary); Duca, Vittorio Del [Istituto Nazionale di Fisica Nucleare, Sez. di Torino, via P. Giuria, 1 - 10125 Torino (Italy)

2005-06-01

We describe how to disentangle the singly- and doubly-unresolved (soft and/or collinear) limits of tree-level QCD squared matrix elements. Using the factorization formulae presented in this paper, we outline a viable general subtraction scheme for computing next-to-next-to-leading order corrections for electron-positron annihilation into jets.

A flexible R package for nonnegative matrix factorization

Directory of Open Access Journals (Sweden)

Seoighe Cathal

2010-07-01

Full Text Available Abstract Background Nonnegative Matrix Factorization (NMF is an unsupervised learning technique that has been applied successfully in several fields, including signal processing, face recognition and text mining. Recent applications of NMF in bioinformatics have demonstrated its ability to extract meaningful information from high-dimensional data such as gene expression microarrays. Developments in NMF theory and applications have resulted in a variety of algorithms and methods. However, most NMF implementations have been on commercial platforms, while those that are freely available typically require programming skills. This limits their use by the wider research community. Results Our objective is to provide the bioinformatics community with an open-source, easy-to-use and unified interface to standard NMF algorithms, as well as with a simple framework to help implement and test new NMF methods. For that purpose, we have developed a package for the R/BioConductor platform. The package ports public code to R, and is structured to enable users to easily modify and/or add algorithms. It includes a number of published NMF algorithms and initialization methods and facilitates the combination of these to produce new NMF strategies. Commonly used benchmark data and visualization methods are provided to help in the comparison and interpretation of the results. Conclusions The NMF package helps realize the potential of Nonnegative Matrix Factorization, especially in bioinformatics, providing easy access to methods that have already yielded new insights in many applications. Documentation, source code and sample data are available from CRAN.

Simulation study of the photon quality correction factors of ionization chambers for FiR 1 epithermal neutron beam

International Nuclear Information System (INIS)

Koivunoro, H.; Uusi-Simola, J.; Savolainen, S.; Kotiluoto, P.; Auterinen, I.; Kosunen, A.

2006-01-01

At FiR 1 BNCT facility in Finland, neutron-insensitive Mg(Ar) ionization chambers are used for photon dose measurements in an epithermal neutron beam. Previously, photon sensitivity factors for the chamber for the measurements in a water phantom in FiR 1 beam have been determined experimentally from measurements in 60 Co gamma and in a 6 MV clinical accelerator photon beams. However, the response of the ionization chamber in a water phantom depends on energy spectrum and angle of the photons and the secondary electrons created inside the phantom and may differ depending on type of the irradiation source (accelerator vs. an epithermal neutron beam). Also, the experimental sensitivity factor does not take into account the possible perturbations in the photon production in phantom caused by the ionization chamber materials. Therefore, it is necessary to determine the photon quality correction factors (k Qγ ) for the Mg(Ar) chamber at the FiR 1 beam through computer simulations. In this study, the k Qγ factors have been determined for Mg(Ar) chamber from Monte Carlo calculations of absorbed photon dose at two depths in a water phantom using MCNP code. The k qγ factors obtained with this method are compared to the sensitivity factors determined with measurements in an accelerator photon beam and to the k Qγ factors published previously. (author)

Determination of the air attenuation correction factor for a free air ionization chamber

International Nuclear Information System (INIS)

Silva, Natalia F.; Cintra, Felipe B.; Castro, Maysa C. de; Caldas, Linda V.E.

2016-01-01

The objective of this work is to present the experimental and simulation results for the air attenuation correction factor for a free air ionization chamber with concentric cylinders of Victoreen, model 481-5. This correction factor was obtained for the standard mammography qualities established in the Instrument Calibration Laboratory (LCI) of IPEN. The values were compared with the results from the German primary standard laboratory Physikalisch- Technische Bundesanstalt (PTB), and maximum differences of 0.40% in relation to the experimental value and 0.31% in relation to the simulated value were obtained. (author)

Evaluation of the uniformity of wide circular reference source and application of correction factors

International Nuclear Information System (INIS)

Silva Junior, I.A.; Xavier, M.; Siqueira, P.T.D.; Sordi, G.A.A.; Potiens, M.P.A.

2017-01-01

In this work the uniformity of wide circular reference sources is evaluated. This kind of reference source is still widely used in Brazil. In previous works wide rectangular reference sources were analyzed and it was shown the importance of the application of correction factors in calibration procedures of radiation monitors. Now a transposition of the methods used formerly is performed, evaluating the uniformities of circular reference sources and calculating the associated correction factors. (author)

Corrective Jaw Surgery

Medline Plus

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Status of the NLO Corrections to the Photon Impact Factor

OpenAIRE

Gieseke, Stefan

2002-01-01

We present the status of the programme of calculating the next-to-leading order corrections to the virtual photon impact factor. In particular, we discuss new results for the transversely polarized photon. We briefly outline the definition of infrared finite terms and the subtraction of the leading logarithmic parts.

Efficiency and attenuation correction factors determination in gamma spectrometric assay of bulk samples using self radiation

International Nuclear Information System (INIS)

Haddad, Kh.

2009-02-01

Gamma spectrometry forms the most important and capable tool for measuring radioactive materials. Determination of the efficiency and attenuation correction factors is the most tedious problem in the gamma spectrometric assay of bulk samples. A new experimental and easy method for these correction factors determination using self radiation was proposed in this work. An experimental study of the correlation between self attenuation correction factor and sample thickness and its practical application was also introduced. The work was performed on NORM and uranyl nitrate bulk sample. The results of proposed methods agreed with those of traditional ones.(author)

Non-linear corrections to the cosmological matter power spectrum and scale-dependent galaxy bias: implications for parameter estimation

International Nuclear Information System (INIS)

Hamann, Jan; Hannestad, Steen; Melchiorri, Alessandro; Wong, Yvonne Y Y

2008-01-01

We explore and compare the performances of two non-linear correction and scale-dependent biasing models for the extraction of cosmological information from galaxy power spectrum data, especially in the context of beyond-ΛCDM (CDM: cold dark matter) cosmologies. The first model is the well known Q model, first applied in the analysis of Two-degree Field Galaxy Redshift Survey data. The second, the P model, is inspired by the halo model, in which non-linear evolution and scale-dependent biasing are encapsulated in a single non-Poisson shot noise term. We find that while the two models perform equally well in providing adequate correction for a range of galaxy clustering data in standard ΛCDM cosmology and in extensions with massive neutrinos, the Q model can give unphysical results in cosmologies containing a subdominant free-streaming dark matter whose temperature depends on the particle mass, e.g., relic thermal axions, unless a suitable prior is imposed on the correction parameter. This last case also exposes the danger of analytic marginalization, a technique sometimes used in the marginalization of nuisance parameters. In contrast, the P model suffers no undesirable effects, and is the recommended non-linear correction model also because of its physical transparency

Non-linear corrections to the cosmological matter power spectrum and scale-dependent galaxy bias: implications for parameter estimation

Science.gov (United States)

Hamann, Jan; Hannestad, Steen; Melchiorri, Alessandro; Wong, Yvonne Y. Y.

2008-07-01

We explore and compare the performances of two non-linear correction and scale-dependent biasing models for the extraction of cosmological information from galaxy power spectrum data, especially in the context of beyond-ΛCDM (CDM: cold dark matter) cosmologies. The first model is the well known Q model, first applied in the analysis of Two-degree Field Galaxy Redshift Survey data. The second, the P model, is inspired by the halo model, in which non-linear evolution and scale-dependent biasing are encapsulated in a single non-Poisson shot noise term. We find that while the two models perform equally well in providing adequate correction for a range of galaxy clustering data in standard ΛCDM cosmology and in extensions with massive neutrinos, the Q model can give unphysical results in cosmologies containing a subdominant free-streaming dark matter whose temperature depends on the particle mass, e.g., relic thermal axions, unless a suitable prior is imposed on the correction parameter. This last case also exposes the danger of analytic marginalization, a technique sometimes used in the marginalization of nuisance parameters. In contrast, the P model suffers no undesirable effects, and is the recommended non-linear correction model also because of its physical transparency.

ℓ2,1 Norm and Hessian Regularized Non-Negative Matrix Factorization with Discriminability for Data Representation

Directory of Open Access Journals (Sweden)

Peng Luo

2017-09-01

Full Text Available Matrix factorization based methods have widely been used in data representation. Among them, Non-negative Matrix Factorization (NMF is a promising technique owing to its psychological and physiological interpretation of spontaneously occurring data. On one hand, although traditional Laplacian regularization can enhance the performance of NMF, it still suffers from the problem of its weak extrapolating ability. On the other hand, standard NMF disregards the discriminative information hidden in the data and cannot guarantee the sparsity of the factor matrices. In this paper, a novel algorithm called ℓ 2 , 1 norm and Hessian Regularized Non-negative Matrix Factorization with Discriminability (ℓ 2 , 1 HNMFD, is developed to overcome the aforementioned problems. In ℓ 2 , 1 HNMFD, Hessian regularization is introduced in the framework of NMF to capture the intrinsic manifold structure of the data. ℓ 2 , 1 norm constraints and approximation orthogonal constraints are added to assure the group sparsity of encoding matrix and characterize the discriminative information of the data simultaneously. To solve the objective function, an efficient optimization scheme is developed to settle it. Our experimental results on five benchmark data sets have demonstrated that ℓ 2 , 1 HNMFD can learn better data representation and provide better clustering results.

Hessian regularization based symmetric nonnegative matrix factorization for clustering gene expression and microbiome data.

Science.gov (United States)

Ma, Yuanyuan; Hu, Xiaohua; He, Tingting; Jiang, Xingpeng

2016-12-01

Nonnegative matrix factorization (NMF) has received considerable attention due to its interpretation of observed samples as combinations of different components, and has been successfully used as a clustering method. As an extension of NMF, Symmetric NMF (SNMF) inherits the advantages of NMF. Unlike NMF, however, SNMF takes a nonnegative similarity matrix as an input, and two lower rank nonnegative matrices (H, H T ) are computed as an output to approximate the original similarity matrix. Laplacian regularization has improved the clustering performance of NMF and SNMF. However, Laplacian regularization (LR), as a classic manifold regularization method, suffers some problems because of its weak extrapolating ability. In this paper, we propose a novel variant of SNMF, called Hessian regularization based symmetric nonnegative matrix factorization (HSNMF), for this purpose. In contrast to Laplacian regularization, Hessian regularization fits the data perfectly and extrapolates nicely to unseen data. We conduct extensive experiments on several datasets including text data, gene expression data and HMP (Human Microbiome Project) data. The results show that the proposed method outperforms other methods, which suggests the potential application of HSNMF in biological data clustering. Copyright © 2016. Published by Elsevier Inc.

Fatigue Crack Growth Rate and Stress-Intensity Factor Corrections for Out-of-Plane Crack Growth

Science.gov (United States)

Forth, Scott C.; Herman, Dave J.; James, Mark A.

2003-01-01

Fatigue crack growth rate testing is performed by automated data collection systems that assume straight crack growth in the plane of symmetry and use standard polynomial solutions to compute crack length and stress-intensity factors from compliance or potential drop measurements. Visual measurements used to correct the collected data typically include only the horizontal crack length, which for cracks that propagate out-of-plane, under-estimates the crack growth rates and over-estimates the stress-intensity factors. The authors have devised an approach for correcting both the crack growth rates and stress-intensity factors based on two-dimensional mixed mode-I/II finite element analysis (FEA). The approach is used to correct out-of-plane data for 7050-T7451 and 2025-T6 aluminum alloys. Results indicate the correction process works well for high DeltaK levels but fails to capture the mixed-mode effects at DeltaK levels approaching threshold (da/dN approximately 10(exp -10) meter/cycle).

Fretting fatigue life estimation using fatigue damage gradient correction factor in various contact configurations

Energy Technology Data Exchange (ETDEWEB)

Hwang, Dong Hyeon; Cho, Sung-San [Hongik University, Seoul (Korea, Republic of)

2017-03-15

A fretting fatigue life estimation method that takes into account the stress gradient effect was developed by the authors [Journal of Mechanical Science and Technology, 28 (2014) 2153-2159]. In the developed method, fatigue damage value at the cracking location is corrected with fatigue damage gradient and the corrected value is compared directly with the plain fatigue data for life estimation. In other words, the correction factor is the ratio of plain fatigue damage to fretting fatigue damage at the same life and a function of fatigue damage gradient. Since reliability of the method was verified only for cylinder-on-flat contact configuration in the previous study, the present study extends application of the method to flat-on-flat contact configurations by developing the correction factor for both the contact configuration. Fretting fatigue experiments were conducted to obtain fatigue life data for various fretting pads. Finite element analyses were conducted to evaluate the Smith-Watson-Topper (SWT) fatigue damage parameter in the cracking region. It is revealed that the SWT parameter in fat-on-flat contact configuration decreases exponentially away from the surface as in cylinder-on-flat contact configuration, and thus the SWT gradient at the surface can be evaluated reliably. Moreover, it is found that decrease in the SWT parameter around the cracking location can be expressed by piecewise exponential curves. If the gradient of SWT at the surface is used as a representative value of SWT gradient, it is impossible to establish functional relationship between the SWT gradient and the correction factor for both the contact configurations although it was possible for cylinder-on-flat contact configuration. However, if weighted average of the SWT gradient values obtained from each exponential curve in the piecewise exponential curve is used as a representative value, the correction factor for both the contact configurations becomes a function of the SWT gradient

Seasonal correction factors in radon exposure assessment: are they help or hindrance?

International Nuclear Information System (INIS)

Denman, A.R.; Groves-Kirkby, C.J.; Phillips, P.S.; Woolridge, A.C.; Crockett, R.G.M.

2008-01-01

Northern Hemisphere radon levels are generally higher in Winter than in Summer, primarily due to the increased interior/exterior temperature difference during the heating season, which results in greater atmospheric pressure differential and enhanced radon ingress. Following a survey of domestic radon levels in the United Kingdom (UK), the former National Radiological Protection Board (NRPB) established measurement protocols and promulgated nationally-applicable Seasonal Correction Factors (SCF). These factors convert a one-month or three-month radon concentration measurement, commencing in any month of the year, to an annual mean radon concentration. Subsequent study suggests that this approach may not be sufficiently sensitive to local conditions, and a major independent investigation reported seasonal correction factors specific to nine geographic regions, together with a composite set applicable to all regions. Similar geographical variability has been observed in other countries. In a recent evaluation of the applicability of short-term exposures in quantifying long-term domestic radon levels, radon levels in 34 houses were monitored over a 12-month period with 1-week, 1-month and 3-month exposures. Radon concentration variation departed significantly from that expected on the basis of the recommended SCFs, with year-end discontinuities at all exposure durations. Weekly monitoring with electrets was continued in three of these locations for four years. Short-term variations in radon levels were observed, particularly during the shorter exposures, and this dataset has also shown year-on-year variations. Overall, SCFs derived from this dataset are significantly lower than those recommended, but are comparable with other results from the UK and elsewhere, particularly those that recognise geological diversity and are consequently prepared on a regional rather than a national basis. These findings call into question the validity of using nationally

Learning time-dependent noise to reduce logical errors: real time error rate estimation in quantum error correction

Science.gov (United States)

Huo, Ming-Xia; Li, Ying

2017-12-01

Quantum error correction is important to quantum information processing, which allows us to reliably process information encoded in quantum error correction codes. Efficient quantum error correction benefits from the knowledge of error rates. We propose a protocol for monitoring error rates in real time without interrupting the quantum error correction. Any adaptation of the quantum error correction code or its implementation circuit is not required. The protocol can be directly applied to the most advanced quantum error correction techniques, e.g. surface code. A Gaussian processes algorithm is used to estimate and predict error rates based on error correction data in the past. We find that using these estimated error rates, the probability of error correction failures can be significantly reduced by a factor increasing with the code distance.

An algorithm for mass matrix calculation of internally constrained molecular geometries

International Nuclear Information System (INIS)

Aryanpour, Masoud; Dhanda, Abhishek; Pitsch, Heinz

2008-01-01

Dynamic models for molecular systems require the determination of corresponding mass matrix. For constrained geometries, these computations are often not trivial but need special considerations. Here, assembling the mass matrix of internally constrained molecular structures is formulated as an optimization problem. Analytical expressions are derived for the solution of the different possible cases depending on the rank of the constraint matrix. Geometrical interpretations are further used to enhance the solution concept. As an application, we evaluate the mass matrix for a constrained molecule undergoing an electron-transfer reaction. The preexponential factor for this reaction is computed based on the harmonic model

An algorithm for mass matrix calculation of internally constrained molecular geometries.

Science.gov (United States)

Aryanpour, Masoud; Dhanda, Abhishek; Pitsch, Heinz

2008-01-28

Dynamic models for molecular systems require the determination of corresponding mass matrix. For constrained geometries, these computations are often not trivial but need special considerations. Here, assembling the mass matrix of internally constrained molecular structures is formulated as an optimization problem. Analytical expressions are derived for the solution of the different possible cases depending on the rank of the constraint matrix. Geometrical interpretations are further used to enhance the solution concept. As an application, we evaluate the mass matrix for a constrained molecule undergoing an electron-transfer reaction. The preexponential factor for this reaction is computed based on the harmonic model.

Twisted finite-volume corrections to K{sub l3} decays with partially-quenched and rooted-staggered quarks

Energy Technology Data Exchange (ETDEWEB)

Bernard, Claude [Department of Physics, Washington University,One Brookings Drive, Saint Louis (United States); Bijnens, Johan [Department of Astronomy and Theoretical Physics, Lund University,Sölvegatan 14A, SE 223-62 Lund (Sweden); Gámiz, Elvira [CAFPE and Departamento de Física Teórica y del Cosmos, Universidad de Granada,Campus de Fuente Nueva, E-18002 Granada (Spain); Relefors, Johan [Department of Astronomy and Theoretical Physics, Lund University,Sölvegatan 14A, SE 223-62 Lund (Sweden)

2017-03-23

The determination of |V{sub us}| from kaon semileptonic decays requires the value of the form factor f{sub +}(q{sup 2}=0) which can be calculated precisely on the lattice. We provide the one-loop partially quenched chiral perturbation theory expressions both with and without including the effects of staggered quarks for all form factors at finite volume and with partially twisted boundary conditions for both the vector current and scalar density matrix elements at all q{sup 2}. We point out that at finite volume there are more form factors than just f{sub +} and f{sub −} for the vector current matrix element but that the Ward identity is fully satisfied. The size of the finite-volume corrections at present lattice sizes is small. This will help improve the lattice determination of f{sub +}(q{sup 2}=0) since the finite-volume error is the dominant error source for some calculations. The size of the finite-volume corrections may be estimated on a single lattice ensemble by comparing results for various twist choices.

Continuous correction of differential path length factor in near-infrared spectroscopy.

Science.gov (United States)

Talukdar, Tanveer; Moore, Jason H; Diamond, Solomon G

2013-05-01

In continuous-wave near-infrared spectroscopy (CW-NIRS), changes in the concentration of oxyhemoglobin and deoxyhemoglobin can be calculated by solving a set of linear equations from the modified Beer-Lambert Law. Cross-talk error in the calculated hemodynamics can arise from inaccurate knowledge of the wavelength-dependent differential path length factor (DPF). We apply the extended Kalman filter (EKF) with a dynamical systems model to calculate relative concentration changes in oxy- and deoxyhemoglobin while simultaneously estimating relative changes in DPF. Results from simulated and experimental CW-NIRS data are compared with results from a weighted least squares (WLSQ) method. The EKF method was found to effectively correct for artificially introduced errors in DPF and to reduce the cross-talk error in simulation. With experimental CW-NIRS data, the hemodynamic estimates from EKF differ significantly from the WLSQ (p EKF method compared to WLSQ in three physiologically relevant spectral bands 0.04 to 0.15 Hz, 0.15 to 0.4 Hz and 0.4 to 2.0 Hz (p EKF method.

PET/CT detectability and classification of simulated pulmonary lesions using an SUV correction scheme

Science.gov (United States)

Morrow, Andrew N.; Matthews, Kenneth L., II; Bujenovic, Steven

2008-03-01

Positron emission tomography (PET) and computed tomography (CT) together are a powerful diagnostic tool, but imperfect image quality allows false positive and false negative diagnoses to be made by any observer despite experience and training. This work investigates PET acquisition mode, reconstruction method and a standard uptake value (SUV) correction scheme on the classification of lesions as benign or malignant in PET/CT images, in an anthropomorphic phantom. The scheme accounts for partial volume effect (PVE) and PET resolution. The observer draws a region of interest (ROI) around the lesion using the CT dataset. A simulated homogenous PET lesion of the same shape as the drawn ROI is blurred with the point spread function (PSF) of the PET scanner to estimate the PVE, providing a scaling factor to produce a corrected SUV. Computer simulations showed that the accuracy of the corrected PET values depends on variations in the CT-drawn boundary and the position of the lesion with respect to the PET image matrix, especially for smaller lesions. Correction accuracy was affected slightly by mismatch of the simulation PSF and the actual scanner PSF. The receiver operating characteristic (ROC) study resulted in several observations. Using observer drawn ROIs, scaled tumor-background ratios (TBRs) more accurately represented actual TBRs than unscaled TBRs. For the PET images, 3D OSEM outperformed 2D OSEM, 3D OSEM outperformed 3D FBP, and 2D OSEM outperformed 2D FBP. The correction scheme significantly increased sensitivity and slightly increased accuracy for all acquisition and reconstruction modes at the cost of a small decrease in specificity.

Dielectric matrix, dynamical matrix and phonon dispersion in hcp transition metal scandium

International Nuclear Information System (INIS)

Singh, Joginder; Singh, Natthi; Prakash, S.

1976-01-01

Complete dielectric matrix is evaluated for hcp transition metal scandium using the non-interacting s- and d-band model. The local field corrections which are consequence of the non-diagonal part of the dielectric matrix are calculated explicitly. The free electron approximation is used for the s-electrons and the simple tight-binding approximation is used for the d-electrons. The theory developed by Singh and others is used to invert the dielectric matrix and the explicit expressions for the dynamical matrix are obtained. The phonon dispersion relations are investigated by using the renormalized Animalu transition metal model potential (TMMP) for bare ion potential. The contribution due to non-central forces which arise due to local fields is found to be 20%. The results are found in resonably good agreement with the experimental values. (author)

Compound nucleus in Livsic open-system theory: Factorization of the S matrix

International Nuclear Information System (INIS)

Avishai, Y.

1988-01-01

The compound-nucleus system fits into a mathematical theory of open systems in physics developed by the mathematician M. Livsic [Translations of Mathematical Monographs (American Mathematical Society, Providence, Rhode Island, 1973), Vol. 34]. In this article we review some basic concepts of the above theory and apply it to study the structure of the compound-nucleus S matrix. One of the results is a factorization of the S matrix in the form S(ω) = S +iA/sub k//(tau/sub k/-ω)], where A/sub k/ are known matrices and tau/sub k/ are the complex resonance energies

Matrix-Dependent Regulation of AKT in Hepsin-Overexpressing PC3 Prostate Cancer Cells

Directory of Open Access Journals (Sweden)

Stephanie M Wittig-Blaich

2011-07-01

Full Text Available The serine-protease hepsin is one of the most prominently overexpressed genes in human prostate carcinoma. Forced expression of the enzyme in mice prostates is associated with matrix degradation, invasive growth, and prostate cancer progression. Conversely, hepsin overexpression in metastatic prostate cancer cell lines was reported to induce cell cycle arrest and reduction of invasive growth in vitro. We used a system for doxycycline (dox-inducible target gene expression in metastasis-derived PC3 cells to analyze the effects of hepsin in a quantitative manner. Loss of viability and adhesion correlated with hepsin expression levels during anchorage-dependent but not anchorage-independent growth. Full expression of hepsin led to cell death and detachment and was specifically associated with reduced phosphorylation of AKT at Ser473, which was restored by growth on matrix derived from RWPE1 normal prostatic epithelial cells. In the chorioallantoic membrane xenograft model, hepsin overexpression in PC3 cells reduced the viability of tumors but did not suppress invasive growth. The data presented here provide evidence that elevated levels of hepsin interfere with cell adhesion and viability in the background of prostate cancer as well as other tissue types, the details of which depend on the microenvironment provided. Our findings suggest that overexpression of the enzyme in prostate carcinogenesis must be spatially and temporally restricted for the efficient development of tumors and metastases.

Calibration and correction of LA-ICP-MS and LA-MC-ICP-MS analyses for element contents and isotopic ratios

Directory of Open Access Journals (Sweden)

Jie Lin

2016-06-01

Full Text Available LA-ICP-MS and LA-MC-ICP-MS have been the techniques of choice for achieving accurate and precise element content and isotopic ratio, the state-of-the-art technique combines the advantages of low detection limits with high spatial resolution, however, the analysis accuracy and precision are restricted by many factors, such as sensitivity drift, elemental/isotopic fractionation, matrix effects, interferences and the lack of sufficiently matrix-matched reference materials. Thus, rigorous and suitable calibration and correction methods are needed to obtain quantitative data. This review systematically summarized and evaluated the interference correction, quantitative calculation and sensitivity correction strategies in order to provide the analysts with suitable calibration and correction strategies according to the sample types and the analyzed elements. The functions and features of data reduction software ICPMSDataCal were also outlined, which can provide real-time and on-line data reduction of element content and isotopic ratios analyzed by LA-ICP-MS and LA-MC-ICP-MS.

Self-consistent RPA and the time-dependent density matrix approach

Energy Technology Data Exchange (ETDEWEB)

Schuck, P. [Institut de Physique Nucleaire, Orsay (France); CNRS et Universite Joseph Fourier, Laboratoire de Physique et Modelisation des Milieux Condenses, Grenoble (France); Tohyama, M. [Kyorin University School of Medicine, Mitaka, Tokyo (Japan)

2016-10-15

The time-dependent density matrix (TDDM) or BBGKY (Bogoliubov, Born, Green, Kirkwood, Yvon) approach is decoupled and closed at the three-body level in finding a natural representation of the latter in terms of a quadratic form of two-body correlation functions. In the small amplitude limit an extended RPA coupled to an also extended second RPA is obtained. Since including two-body correlations means that the ground state cannot be a Hartree-Fock state, naturally the corresponding RPA is upgraded to Self-Consistent RPA (SCRPA) which was introduced independently earlier and which is built on a correlated ground state. SCRPA conserves all the properties of standard RPA. Applications to the exactly solvable Lipkin and the 1D Hubbard models show good performances of SCRPA and TDDM. (orig.)

Calculations of electron fluence correction factors using the Monte Carlo code PENELOPE

International Nuclear Information System (INIS)

Siegbahn, E A; Nilsson, B; Fernandez-Varea, J M; Andreo, P

2003-01-01

In electron-beam dosimetry, plastic phantom materials may be used instead of water for the determination of absorbed dose to water. A correction factor φ water plastic is then needed for converting the electron fluence in the plastic phantom to the fluence at an equivalent depth in water. The recommended values for this factor given by AAPM TG-25 (1991 Med. Phys. 18 73-109) and the IAEA protocols TRS-381 (1997) and TRS-398 (2000) disagree, in particular at large depths. Calculations of the electron fluence have been done, using the Monte Carlo code PENELOPE, in semi-infinite phantoms of water and common plastic materials (PMMA, clear polystyrene, A-150, polyethylene, Plastic water TM and Solid water TM (WT1)). The simulations have been carried out for monoenergetic electron beams of 6, 10 and 20 MeV, as well as for a realistic clinical beam. The simulated fluence correction factors differ from the values in the AAPM and IAEA recommendations by up to 2%, and are in better agreement with factors obtained by Ding et al (1997 Med. Phys. 24 161-76) using EGS4. Our Monte Carlo calculations are also in good accordance with φ water plastic values measured by using an almost perturbation-free ion chamber. The important interdependence between depth- and fluence-scaling corrections for plastic phantoms is discussed. Discrepancies between the measured and the recommended values of φ water plastic may then be explained considering the different depth-scaling rules used

Dynamic SPECT reconstruction from few projections: a sparsity enforced matrix factorization approach

Science.gov (United States)

Ding, Qiaoqiao; Zan, Yunlong; Huang, Qiu; Zhang, Xiaoqun

2015-02-01

The reconstruction of dynamic images from few projection data is a challenging problem, especially when noise is present and when the dynamic images are vary fast. In this paper, we propose a variational model, sparsity enforced matrix factorization (SEMF), based on low rank matrix factorization of unknown images and enforced sparsity constraints for representing both coefficients and bases. The proposed model is solved via an alternating iterative scheme for which each subproblem is convex and involves the efficient alternating direction method of multipliers (ADMM). The convergence of the overall alternating scheme for the nonconvex problem relies upon the Kurdyka-Łojasiewicz property, recently studied by Attouch et al (2010 Math. Oper. Res. 35 438) and Attouch et al (2013 Math. Program. 137 91). Finally our proof-of-concept simulation on 2D dynamic images shows the advantage of the proposed method compared to conventional methods.

Nonnegative matrix factorization with the Itakura-Saito divergence: with application to music analysis.

Science.gov (United States)

Févotte, Cédric; Bertin, Nancy; Durrieu, Jean-Louis

2009-03-01

This letter presents theoretical, algorithmic, and experimental results about nonnegative matrix factorization (NMF) with the Itakura-Saito (IS) divergence. We describe how IS-NMF is underlaid by a well-defined statistical model of superimposed gaussian components and is equivalent to maximum likelihood estimation of variance parameters. This setting can accommodate regularization constraints on the factors through Bayesian priors. In particular, inverse-gamma and gamma Markov chain priors are considered in this work. Estimation can be carried out using a space-alternating generalized expectation-maximization (SAGE) algorithm; this leads to a novel type of NMF algorithm, whose convergence to a stationary point of the IS cost function is guaranteed. We also discuss the links between the IS divergence and other cost functions used in NMF, in particular, the Euclidean distance and the generalized Kullback-Leibler (KL) divergence. As such, we describe how IS-NMF can also be performed using a gradient multiplicative algorithm (a standard algorithm structure in NMF) whose convergence is observed in practice, though not proven. Finally, we report a furnished experimental comparative study of Euclidean-NMF, KL-NMF, and IS-NMF algorithms applied to the power spectrogram of a short piano sequence recorded in real conditions, with various initializations and model orders. Then we show how IS-NMF can successfully be employed for denoising and upmix (mono to stereo conversion) of an original piece of early jazz music. These experiments indicate that IS-NMF correctly captures the semantics of audio and is better suited to the representation of music signals than NMF with the usual Euclidean and KL costs.

Matrix Effects in XRF Measurements

International Nuclear Information System (INIS)

Kandil, A.T.; Gabr, N.A.; El-Aryan, S.M.

2015-01-01

This research treats the matrix effect on XRF measurements. The problem is treated by preparing general oxide program, which contains many samples that represent all materials in cement factories, then by using T rail Lachance m ethod to correct errors of matrix effect. This work compares the effect of using lithium tetraborate or sodium tetraborate as a fluxing agent in terms of accuracy and economic cost

Design of The High Efficiency Power Factor Correction Circuit for Power Supply

Directory of Open Access Journals (Sweden)

Atiye Hülya OBDAN

2017-12-01

Full Text Available Designing power factor correction circuits for switched power supplies has become important in recent years in terms of efficient use of energy. Power factor correction techniques play a significant role in high power density and energy efficiency. For these purposes, bridgeless PFC topologies and control strategies have been developed alongside basic boost PFC circuits. The power density can be increased using bridgeless structures by means of reducing losses in the circuit. This article examines bridgeless PFC structures and compares their performances in terms of losses and power factor. A semi-bridgeless PFC, which is widely used at high power levels, was analyzed and simulated. The designed circuit simulation using the current mode control method was performed in the PSIM program. A prototype of a 900 W semi-bridgeless PFC circuit was implemented and the results obtained from the circuit are presented

Correction factors for photon spectrometry in nuclear parameters study

International Nuclear Information System (INIS)

Patrao, Karla Cristina de Souza

2004-10-01

The goal of this work was the determination, using metrologic severity, the factors of correction for coincidences XX, Xγ and γγ and the factors of transference of efficiency for use in gamma spectrometry. On this way, it was carried through by determination of nuclear parameters of a nuclide used in medicine diagnostic ( 201 Tl) and the standardization of two environmental samples, of regular and irregular geometry, proceeding from the residual (ashes and slag) from the nuclear industry. The results shows that this adopted methodology is valid, and it allows its application for many different nuclides, including complex decay schema nuclides, using only photons spectrometry techniques on semiconductor detectors. (author)

On some features of the effective behaviour of porous solids with J2- and J3-dependent yielding matrix behaviour

Science.gov (United States)

Benallal, Ahmed

2018-02-01

Some features od the constitutive behaviour of voided materials taking into account possible effects of the Lode angle in the yielding behaviour of the matrix are discussed. The Gurson approach is used to this end. After providing a parametric representation of the effective behaviour of such materials, some closed-form results are given for pure shear stress states and also at very high stress triaxialities. In the former case corresponding to a zero macroscopic mean stress, the contour of the yield domain in the π-plane has exactly the shape of the yield surface of the matrix in the deviatoric plane, but a size reduced by a factor 1 - f, with f the porosity of the voided material. In the latter, effective yield stresses for the voided material are slightly different from the Gurson result and found to be set by the yield stress at a microscopic stress Lode angle π/3 for very high positive triaxiality and by the yield stress at a microscopic stress Lode angle 0 for very high negative triaxiality. This last result is extended for porous materials with yielding depending further on the hydrostatic stress, fully exhibiting the interaction between volumetric and shear interactions on the yielding behaviour of isotropic porous materials. Applications to many usual yielding criteria for the matrix are also provided. xml:lang="fr"

Gauge dependence and new kind of two-dimensional gravity theory with trivial quantum corrections

International Nuclear Information System (INIS)

Banin, A.T.; Shapiro, I.L.

1993-12-01

We search for the new kinds of classical potentials in two-dimensional induced gravity, which provide the triviality of the one-loop quantum corrections. First of all the gauge dependence of the effective potential is studied. The unique effective potential, introduced by Vilkovisly in 1984 is found to manifest the gauge dependence due to some unusual properties of the theory under consideration. Then we take the gauge of harmonical type, which provides the one-loop finiteness off shell, and then the solution for the required classical potential is found. (author). 35 refs

Matrix Intensification Affects Body and Physiological Condition of Tropical Forest-Dependent Passerines.

Science.gov (United States)

Deikumah, Justus P; McAlpine, Clive A; Maron, Martine

2015-01-01

Matrix land-use intensification is a relatively recent and novel landscape change that can have important influences on the biota within adjacent habitat patches. While there are immediate local changes that it brings about, the influences on individual animals occupying adjacent habitats may be less evident initially. High-intensity land use could induce chronic stress in individuals in nearby remnants, leading ultimately to population declines. We investigated how physiological indicators and body condition measures of tropical forest-dependent birds differ between forest adjacent to surface mining sites and that near farmlands at two distances from remnant edge in southwest Ghana. We used mixed effects models of several condition indices including residual body mass and heterophil to lymphocyte (H/L) ratios (an indicator of elevated chronic stress) to explore the effect of matrix intensity on forest-dependent passerines classed as either sedentary area-sensitive habitat specialists or nomadic generalists. Individual birds occupying tropical forest remnants near surface mining sites were in poorer condition, as indicated by lower residual body mass and elevated chronic stress, compared to those in remnants near agricultural lands. The condition of the sedentary forest habitat specialists white-tailed alethe, Alethe diademata and western olive sunbird, Cyanomitra obscura was most negatively affected by high-intensity surface mining land-use adjacent to remnants, whereas generalist species were not affected. Land use intensification may set in train a new trajectory of faunal relaxation beyond that expected based on habitat loss alone. Patterns of individual condition may be useful in identifying habitats where species population declines may occur before faunal relaxation has concluded.

Determination of temperature dependence of full matrix material constants of PZT-8 piezoceramics using only one sample.

Science.gov (United States)

Zhang, Yang; Tang, Liguo; Tian, Hua; Wang, Jiyang; Cao, Wenwu; Zhang, Zhongwu

2017-08-15

Resonant ultrasound spectroscopy (RUS) was used to determine the temperature dependence of full matrix material constants of PZT-8 piezoceramics from room temperature to 100 °C. Property variations from sample to samples can be eliminated by using only one sample, so that data self-consistency can be guaranteed. The RUS measurement system error was estimated to be lower than 2.35%. The obtained full matrix material constants at different temperatures all have excellent self-consistency, which can help accurately predict device performance at high temperatures using finite element simulations.

Determination of velocity correction factors for real-time air velocity monitoring in underground mines.

Science.gov (United States)

Zhou, Lihong; Yuan, Liming; Thomas, Rick; Iannacchione, Anthony

2017-12-01

When there are installations of air velocity sensors in the mining industry for real-time airflow monitoring, a problem exists with how the monitored air velocity at a fixed location corresponds to the average air velocity, which is used to determine the volume flow rate of air in an entry with the cross-sectional area. Correction factors have been practically employed to convert a measured centerline air velocity to the average air velocity. However, studies on the recommended correction factors of the sensor-measured air velocity to the average air velocity at cross sections are still lacking. A comprehensive airflow measurement was made at the Safety Research Coal Mine, Bruceton, PA, using three measuring methods including single-point reading, moving traverse, and fixed-point traverse. The air velocity distribution at each measuring station was analyzed using an air velocity contour map generated with Surfer ® . The correction factors at each measuring station for both the centerline and the sensor location were calculated and are discussed.

A study of coarse mesh collision probability correction factors in slab lattices

International Nuclear Information System (INIS)

Buckler, A.N.

1975-07-01

Calculations of collision probability leakage estimates are performed in one dimensional slab geometry with one neutron group to gain some insight into methods of correction for the coarseness of the mesh H. The chief result is that the correction factor, beta, can be written as CD/H where C → 4 for the diffusion limit. An explicit expression for C is derived in terms of the E 3 function, for a linear flux variation across the slabs. (author)

Matrix effect and correction by standard addition in quantitative liquid chromatographic-mass spectrometric analysis of diarrhetic shellfish poisoning toxins.

Science.gov (United States)

Ito, Shinya; Tsukada, Katsuo

2002-01-11

An evaluation of the feasibility of liquid chromatography-mass spectrometry (LC-MS) with atmospheric pressure ionization was made for quantitation of four diarrhetic shellfish poisoning toxins, okadaic acid, dinophysistoxin-1, pectenotoxin-6 and yessotoxin in scallops. When LC-MS was applied to the analysis of scallop extracts, large signal suppressions were observed due to coeluting substances from the column. To compensate for these matrix signal suppressions, the standard addition method was applied. First, the sample was analyzed and then the sample involving the addition of calibration standards is analyzed. Although this method requires two LC-MS runs per analysis, effective correction of quantitative errors was found.

The non-uniformity correction factor for the cylindrical ionization chambers in dosimetry of an HDR 192Ir brachytherapy source

International Nuclear Information System (INIS)

Majumdar, Bishnu; Patel, Narayan Prasad; Vijayan, V.

2006-01-01

The aim of this study is to derive the non-uniformity correction factor for the two therapy ionization chambers for the dose measurement near the brachytherapy source. The two ionization chambers of 0.6 cc and 0.1 cc volume were used. The measurement in air was performed for distances between 0.8 cm and 20 cm from the source in specially designed measurement jig. The non-uniformity correction factors were derived from the measured values. The experimentally derived factors were compared with the theoretically calculated non-uniformity correction factors and a close agreement was found between these two studies. The experimentally derived non-uniformity correction factor supports the anisotropic theory. (author)

Neighborhood Regularized Logistic Matrix Factorization for Drug-Target Interaction Prediction.

Science.gov (United States)

Liu, Yong; Wu, Min; Miao, Chunyan; Zhao, Peilin; Li, Xiao-Li

2016-02-01

In pharmaceutical sciences, a crucial step of the drug discovery process is the identification of drug-target interactions. However, only a small portion of the drug-target interactions have been experimentally validated, as the experimental validation is laborious and costly. To improve the drug discovery efficiency, there is a great need for the development of accurate computational approaches that can predict potential drug-target interactions to direct the experimental verification. In this paper, we propose a novel drug-target interaction prediction algorithm, namely neighborhood regularized logistic matrix factorization (NRLMF). Specifically, the proposed NRLMF method focuses on modeling the probability that a drug would interact with a target by logistic matrix factorization, where the properties of drugs and targets are represented by drug-specific and target-specific latent vectors, respectively. Moreover, NRLMF assigns higher importance levels to positive observations (i.e., the observed interacting drug-target pairs) than negative observations (i.e., the unknown pairs). Because the positive observations are already experimentally verified, they are usually more trustworthy. Furthermore, the local structure of the drug-target interaction data has also been exploited via neighborhood regularization to achieve better prediction accuracy. We conducted extensive experiments over four benchmark datasets, and NRLMF demonstrated its effectiveness compared with five state-of-the-art approaches.

Regression dilution bias: tools for correction methods and sample size calculation.

Science.gov (United States)

Berglund, Lars

2012-08-01

Random errors in measurement of a risk factor will introduce downward bias of an estimated association to a disease or a disease marker. This phenomenon is called regression dilution bias. A bias correction may be made with data from a validity study or a reliability study. In this article we give a non-technical description of designs of reliability studies with emphasis on selection of individuals for a repeated measurement, assumptions of measurement error models, and correction methods for the slope in a simple linear regression model where the dependent variable is a continuous variable. Also, we describe situations where correction for regression dilution bias is not appropriate. The methods are illustrated with the association between insulin sensitivity measured with the euglycaemic insulin clamp technique and fasting insulin, where measurement of the latter variable carries noticeable random error. We provide software tools for estimation of a corrected slope in a simple linear regression model assuming data for a continuous dependent variable and a continuous risk factor from a main study and an additional measurement of the risk factor in a reliability study. Also, we supply programs for estimation of the number of individuals needed in the reliability study and for choice of its design. Our conclusion is that correction for regression dilution bias is seldom applied in epidemiological studies. This may cause important effects of risk factors with large measurement errors to be neglected.

Leading quantum gravitational corrections to scalar QED

International Nuclear Information System (INIS)

Bjerrum-Bohr, N.E.J.

2002-01-01

We consider the leading post-Newtonian and quantum corrections to the non-relativistic scattering amplitude of charged scalars in the combined theory of general relativity and scalar QED. The combined theory is treated as an effective field theory. This allows for a consistent quantization of the gravitational field. The appropriate vertex rules are extracted from the action, and the non-analytic contributions to the 1-loop scattering matrix are calculated in the non-relativistic limit. The non-analytical parts of the scattering amplitude, which are known to give the long range, low energy, leading quantum corrections, are used to construct the leading post-Newtonian and quantum corrections to the two-particle non-relativistic scattering matrix potential for two charged scalars. The result is discussed in relation to experimental verifications

Self-attenuation correction factors for bioindicators measured by γ spectrometry for energies <100keV

International Nuclear Information System (INIS)

Manduci, L.; Tenailleau, L.; Trolet, J.L.; De Vismes, A.; Lopez, G.; Piccione, M.

2010-01-01

The mass attenuation coefficients for a number of marine and terrestrial bioindicators were measured using γ spectrometry for energies between 22 and 80 keV. These values were then used to find the correction factor k for the apparent radioactivity. The experimental results were compared with a Monte Carlo simulation performed using PENELOPE in order to evaluate the reliability of the simplified calculation and to determine the correction factors.

The interplay of matrix metalloproteinases, morphogens and growth factors is necessary for branching of mammary epithelial cells

International Nuclear Information System (INIS)

Simian, Marina; Hirai, Yohei; Navre, Marc; Werb, Zena; Lochter, Andre; Bissell, Mina J.

2002-01-01

The mammary gland develops its adult form by a process referred to as branching morphogenesis. Many factors have been reported to affect this process. We have used cultured primary mammary epithelial organoids and mammary epithelial cell lines in three-dimensional collagen gels to elucidate which growth factors, matrix metalloproteinases (MMPs) and mammary morphogens interact in branching morphogenesis. Branching stimulated by stromal fibroblasts, epidermal growth factor, fibroblast growth factor 7, fibroblast growth factor 2 and hepatocyte growth factor was strongly reduced by inhibitors of MMPs, indicating the requirement of MMPs for three-dimensional growth involved in morphogenesis. Recombinant stromelysin 1/MMP-3 alone was sufficient to drive branching in the absence of growth factors in the organoids. Plasmin also stimulated branching; however, plasmin-dependent branching was abolished by both inhibitors of plasmin and MMPs, suggesting that plasmin activates MMPs. To differentiate between signals for proliferation and morphogenesis, we used a cloned mammary epithelial cell line that lacks epimorphin, an essential mammary morphogen. Both epimorphin and MMPs were required for morphogenesis, but neither was required for epithelial cell proliferation. These results provide direct evidence for a critical role of MMPs in branching in mammary epithelium and suggest that, in addition to epimorphin, MMP activity is a minimum requirement for branching morphogenesis in the mammary gland

The interplay of matrix metalloproteinases, morphogens and growth factors is necessary for branching of mammary epithelial cells

Energy Technology Data Exchange (ETDEWEB)

Simian, M.; Harail, Y.; Navre, M.; Werb, Z.; Lochter, A.; Bissell, M.J.

2002-03-06

The mammary gland develops its adult form by a process referred to as branching morphogenesis. Many factors have been reported to affect this process. We have used cultured primary mammary epithelial organoids and mammary epithelial cell lines in three-dimensional collagen gels to elucidate which growth factors, matrix metalloproteinases (MMPs) and mammary morphogens interact in branching morphogenesis. Branching stimulated by stromal fibroblasts, epidermal growth factor, fibroblast growth factor 7, fibroblast growth factor 2 and hepatocyte growth factor was strongly reduced by inhibitors of MMPs, indicating the requirement of MMPs for three-dimensional growth involved in morphogenesis. Recombinant stromelysin 1/MMP-3 alone was sufficient to drive branching in the absence of growth factors in the organoids. Plasmin also stimulated branching; however, plasmin-dependent branching was abolished by both inhibitors of plasmin and MMPs, suggesting that plasmin activates MMPs. To differentiate between signals for proliferation and morphogenesis, we used a cloned mammary epithelial cell line that lacks epimorphin, an essential mammary morphogen. Both epimorphin and MMPs were required for morphogenesis, but neither was required for epithelial cell proliferation. These results provide direct evidence for a critical role of MMPs in branching in mammary epithelium and suggest that, in addition to epimorphin, MMP activity is a minimum requirement for branching morphogenesis in the mammary gland.

Novel scatter compensation with energy and spatial dependent corrections in positron emission tomography

International Nuclear Information System (INIS)

Guerin, Bastien

2010-01-01

We developed and validated a fast Monte Carlo simulation of PET acquisitions based on the SimSET program modeling accurately the propagation of gamma photons in the patient as well as the block-based PET detector. Comparison of our simulation with another well validated code, GATE, and measurements on two GE Discovery ST PET scanners showed that it models accurately energy spectra (errors smaller than 4.6%), the spatial resolution of block-based PET scanners (6.1%), scatter fraction (3.5%), sensitivity (2.3%) and count rates (12.7%). Next, we developed a novel scatter correction incorporating the energy and position of photons detected in list-mode. Our approach is based on the reformulation of the list-mode likelihood function containing the energy distribution of detected coincidences in addition to their spatial distribution, yielding an EM reconstruction algorithm containing spatial and energy dependent correction terms. We also proposed using the energy in addition to the position of gamma photons in the normalization of the scatter sinogram. Finally, we developed a method for estimating primary and scatter photons energy spectra from total spectra detected in different sectors of the PET scanner. We evaluated the accuracy and precision of our new spatio-spectral scatter correction and that of the standard spatial correction using realistic Monte Carlo simulations. These results showed that incorporating the energy in the scatter correction reduces bias in the estimation of the absolute activity level by ∼ 60% in the cold regions of the largest patients and yields quantification errors less than 13% in all regions. (author)

Determination of several trace elements in silicate rocks by an XRF method with background and matrix corrections

International Nuclear Information System (INIS)

Pascual, J.

1987-01-01

An X-ray fluorescence method for determining trace elements in silicate rock samples was studied. The procedure focused on the application of the pertinent matrix corrections. Either the Compton peak or the reciprocal of the mass absorption coefficient of the sample was used as internal standard for this purpose. X-ray tubes with W or Cr anodes were employed, and the W Lβ and Cr Kα Compton intensities scattered by the sample were measured. The mass absorption coefficients at both sides of the absorption edge for Fe (1.658 and 1.936 A) were calculated. The elements Zr, Y, Rb, Zn, Ni, Cr and V were determined in 15 international reference rocks covering wide ranges of concentration. Relative mean errors were in many cases less than 10%. (author)

Beyond cross-domain learning: Multiple-domain nonnegative matrix factorization

KAUST Repository

Wang, Jim Jing-Yan; Gao, Xin

2014-01-01

Traditional cross-domain learning methods transfer learning from a source domain to a target domain. In this paper, we propose the multiple-domain learning problem for several equally treated domains. The multiple-domain learning problem assumes that samples from different domains have different distributions, but share the same feature and class label spaces. Each domain could be a target domain, while also be a source domain for other domains. A novel multiple-domain representation method is proposed for the multiple-domain learning problem. This method is based on nonnegative matrix factorization (NMF), and tries to learn a basis matrix and coding vectors for samples, so that the domain distribution mismatch among different domains will be reduced under an extended variation of the maximum mean discrepancy (MMD) criterion. The novel algorithm - multiple-domain NMF (MDNMF) - was evaluated on two challenging multiple-domain learning problems - multiple user spam email detection and multiple-domain glioma diagnosis. The effectiveness of the proposed algorithm is experimentally verified. © 2013 Elsevier Ltd. All rights reserved.

Beyond cross-domain learning: Multiple-domain nonnegative matrix factorization

KAUST Repository

Wang, Jim Jing-Yan

2014-02-01

Traditional cross-domain learning methods transfer learning from a source domain to a target domain. In this paper, we propose the multiple-domain learning problem for several equally treated domains. The multiple-domain learning problem assumes that samples from different domains have different distributions, but share the same feature and class label spaces. Each domain could be a target domain, while also be a source domain for other domains. A novel multiple-domain representation method is proposed for the multiple-domain learning problem. This method is based on nonnegative matrix factorization (NMF), and tries to learn a basis matrix and coding vectors for samples, so that the domain distribution mismatch among different domains will be reduced under an extended variation of the maximum mean discrepancy (MMD) criterion. The novel algorithm - multiple-domain NMF (MDNMF) - was evaluated on two challenging multiple-domain learning problems - multiple user spam email detection and multiple-domain glioma diagnosis. The effectiveness of the proposed algorithm is experimentally verified. © 2013 Elsevier Ltd. All rights reserved.

Dependent data in social sciences research forms, issues, and methods of analysis

CERN Document Server

Eye, Alexander; Wiedermann, Wolfgang

2015-01-01

This volume presents contributions on handling data in which the postulate of independence in the data matrix is violated. When this postulate is violated and when the methods assuming independence are still applied, the estimated parameters are likely to be biased, and statistical decisions are very likely to be incorrect. Problems associated with dependence in data have been known for a long time, and led to the development of tailored methods for the analysis of dependent data in various areas of statistical analysis. These methods include, for example, methods for the analysis of longitudinal data, corrections for dependency, and corrections for degrees of freedom. This volume contains the following five sections: growth curve modeling, directional dependence, dyadic data modeling, item response modeling (IRT), and other methods for the analysis of dependent data (e.g., approaches for modeling cross-section dependence, multidimensional scaling techniques, and mixed models). Researchers and graduate stud...

Experimental determination of the weighting factor for the energy window subtraction-based downscatter correction for I-123 in brain SPECT studies

DEFF Research Database (Denmark)

de Nijs, Robin; Holm, Søren; Thomsen, Gerda

2010-01-01

Correction for downscatter in I-123 SPECT can be performed by the subtraction of a secondary energy window from the main window, as in the triple-energy window method. This is potentially noise sensitive. For studies with limited amount of counts (e.g. dynamic studies), a broad subtraction window...... were investigated in this study. Energy windows with a width of 32 keV were centered at 159 keV and 200 keV. The weighting factor was measured both with an I-123 point source and in a dopamine transporter brain SPECT study in 10 human subjects (5 healthy subjects and 5 patients) by minimizing...... the background outside the head. Weighting factors ranged from 1.11 to 1.13 for the point source and from 1.16 to 1.18 for human subjects. Point source measurements revealed no position dependence. After correction, the measured specific binding ratio (image contrast) increased significantly for healthy subjects...

A practical method for determining γ-ray full-energy peak efficiency considering coincidence-summing and self-absorption corrections for the measurement of environmental samples after the Fukushima reactor accident

Energy Technology Data Exchange (ETDEWEB)

Shizuma, Kiyoshi, E-mail: shizuma@hiroshima-u.ac.jp [Graduate School of Engineering, Hiroshima University, Higashi-Hiroshima 739-8527 (Japan); Oba, Yurika; Takada, Momo [Graduate School of Integrated Arts and Sciences, Hiroshima University, Higashi-Hiroshima 739-8521 (Japan)

2016-09-15

A method for determining the γ-ray full-energy peak efficiency at positions close to three Ge detectors and at the well port of a well-type detector was developed for measuring environmental volume samples containing {sup 137}Cs, {sup 134}Cs and {sup 40}K. The efficiency was estimated by considering two correction factors: coincidence-summing and self-absorption corrections. The coincidence-summing correction for a cascade transition nuclide was estimated by an experimental method involving measuring a sample at the far and close positions of a detector. The derived coincidence-summing correction factors were compared with those of analytical and Monte Carlo simulation methods and good agreements were obtained. Differences in the matrix of the calibration source and the environmental sample resulted in an increase or decrease of the full-energy peak counts due to the self-absorption of γ-rays in the sample. The correction factor was derived as a function of the densities of several matrix materials. The present method was applied to the measurement of environmental samples and also low-level radioactivity measurements of water samples using the well-type detector.

Integrals of random fields treated by the model correction factor method

DEFF Research Database (Denmark)

Franchin, P.; Ditlevsen, Ove Dalager; Kiureghian, Armen Der

2002-01-01

The model correction factor method (MCFM) is used in conjunction with the first-order reliability method (FORM) to solve structural reliability problems involving integrals of non-Gaussian random fields. The approach replaces the limit-state function with an idealized one, in which the integrals ...

Iterative CT reconstruction with correction for known rigid motion

Energy Technology Data Exchange (ETDEWEB)

Nuyts, Johan [Katholieke Univ. Leuven (Belgium). Dept. of Nuclear Medicine; Kim, Jung-Ha; Fulton, Roger [Sydney Univ., NSW (Australia). School of Physics; Westmead Hospital, Sydney (Australia). Medical Physics

2011-07-01

In PET/CT brain imaging, correction for motion may be needed, in particular for children and psychiatric patients. Motion is more likely to occur in the lengthy PET measurement, but also during the short CT acquisition patient motion is possible. Rigid motion of the head can be measured independently from the PET/CT system with optical devices. In this paper, we propose a method and some preliminary simulation results for iterative CT reconstruction with correction for known rigid motion. We implemented an iterative algorithm for fully 3D reconstruction from helical CT scans. The motion of the head is incorporated in the system matrix as a view-dependent motion of the CT-system. The first simulation results indicate that some motion patterns may produce loss of essential data. This loss precludes exact reconstruction and results in artifacts in the reconstruction, even when motion is taken into account. However, by reducing the pitch during acquisition, the same motion pattern no longer caused artifacts in the motion corrected image. (orig.)

A transient, Hex-Z nodal code corrected by discontinuity factors

International Nuclear Information System (INIS)

Shatilla, Y.A.M.; Henry, A.F.

1993-01-01

This document constitutes Volume 1 of the Final Report of a three-year study supported by the special Research Grant Program for Nuclear Energy Research set up by the US Department of Energy. The original motivation for the work was to provide a fast and accurate computer program for the analysis of transients in heavy water or graphite-moderated reactors being considered as candidates for the New Production Reactor. Thus, part of the funding was by way of pass-through money from the Savannah River Laboratory. With this intent in mind, a three-dimensional (Hex-Z), general-energy-group transient, nodal code was created, programmed, and tested. In order to improve accuracy, correction terms, called open-quotes discontinuity factors,close quotes were incorporated into the nodal equations. Ideal values of these factors force the nodal equations to provide node-integrated reaction rates and leakage rates across nodal surfaces that match exactly those edited from a more exact reference calculation. Since the exact reference solution is needed to compute the ideal discontinuity factors, the fact that they result in exact nodal equations would be of little practical interest were it not that approximate discontinuity factors, found at a greatly reduced cost, often yield very accurate results. For example, for light-water reactors, discontinuity factors found from two-dimensional, fine-mesh, multigroup transport solutions for two-dimensional cuts of a fuel assembly provide very accurate predictions of three-dimensional, full-core power distributions. The present document (volume 1) deals primarily with the specification, programming and testing of the three-dimensional, Hex-Z computer program. The program solves both the static (eigenvalue) and transient, general-energy-group, nodal equations corrected by user-supplied discontinuity factors

Multiplicative algorithms for constrained non-negative matrix factorization

KAUST Repository

Peng, Chengbin

2012-12-01

Non-negative matrix factorization (NMF) provides the advantage of parts-based data representation through additive only combinations. It has been widely adopted in areas like item recommending, text mining, data clustering, speech denoising, etc. In this paper, we provide an algorithm that allows the factorization to have linear or approximatly linear constraints with respect to each factor. We prove that if the constraint function is linear, algorithms within our multiplicative framework will converge. This theory supports a large variety of equality and inequality constraints, and can facilitate application of NMF to a much larger domain. Taking the recommender system as an example, we demonstrate how a specialized weighted and constrained NMF algorithm can be developed to fit exactly for the problem, and the tests justify that our constraints improve the performance for both weighted and unweighted NMF algorithms under several different metrics. In particular, on the Movielens data with 94% of items, the Constrained NMF improves recall rate 3% compared to SVD50 and 45% compared to SVD150, which were reported as the best two in the top-N metric. © 2012 IEEE.

Constraints on parity-mixing matrix elements from hard-pion exchange corrections to first-forbidden beta decays

International Nuclear Information System (INIS)

Kirchbach, M.

1986-01-01

In this paper the experience in extracting the value of the weak pion-nucleon coupling constant f/sub π//sup l/ from the parity-mixing matrix element + , T = 1; 1.042 MeV | V/sub PNC/ | O - , T = 0; 1.081 MeV> in 18 F is summarized with the aim to reveal some sources of uncertainties of the models exploited. We show that beyond of the long wavelenth approximation and in treating non-soft pion corrections to the two-body nuclear chiral charge density an upper bound for f/sub π//sup l/ is obtained which is about two times smaller as compared to results of previous analyses of similar character. Finally, we accentuate on the importance of the heavy-meson exchanges in the weak NN-potential for understanding recent measurement results of f/sub π//sup l/ which strongly deviate from earlier data. (author)

Blood oxygen level-dependent magnetic resonance imaging for detecting pathological patterns in patients with lupus nephritis: a preliminary study using gray-level co-occurrence matrix analysis.

Science.gov (United States)

Shi, Huilan; Jia, Junya; Li, Dong; Wei, Li; Shang, Wenya; Zheng, Zhenfeng

2018-01-01

Objective Blood oxygen level-dependent magnetic resonance imaging (BOLD MRI) is a noninvasive technique useful in patients with renal disease. The current study was performed to determine whether BOLD MRI can contribute to the diagnosis of renal pathological patterns. Methods BOLD MRI was used to obtain functional magnetic resonance parameter R2* values. Gray-level co-occurrence matrixes (GLCMs) were generated for gray-scale maps. Several GLCM parameters were calculated and used to construct algorithmic models for renal pathological patterns. Results Histopathology and BOLD MRI were used to examine 12 patients. Two GLCM parameters, including correlation and energy, revealed differences among four groups of renal pathological patterns. Four Fisher's linear discriminant formulas were constructed using two variables, including the correlation at 45° and correlation at 90°. A cross-validation test showed that the formulas correctly predicted 28 of 36 samples, and the rate of correct prediction was 77.8%. Conclusions Differences in the texture characteristics of BOLD MRI in patients with lupus nephritis may be detected by GLCM analysis. Discriminant formulas constructed using GLCM parameters may facilitate prediction of renal pathological patterns.

Time dependent deadtime and pile-up corrections for gamma-ray spectroscopy

Energy Technology Data Exchange (ETDEWEB)

Roscoe, B A; Furr, A K [Virginia Polytechnic Inst. and State Univ., Blacksburg (USA)

1977-01-15

The losses of pulses in gamma spectroscopy due to the analog-to-digital (ADC) conversion process and due to pulse pile-up is a major problem in quantitative gamma ray spectroscopy. It is especially serious if the count rate varies significantly during the counting interval and if the nuclear events of interest are associated with an isotope with a half-life shorter than or comparable to the counting interval as is often the case for isotopes with half-lives of the order of 10 min or less. The count rates at which dead time losses become a problem depend upon the available equipment but, in the present work, the problem became acute at count rates in excess of 25000 cps. A technique developed at VPI and SU is discussed in the present work which very satisfactorily corrects for both ADC and pile-up losses and is dependent upon the half-life of the decaying radioisotope.

New look at displacement factor and point of measurement corrections in ionization chamber dosimetry

International Nuclear Information System (INIS)

Awschalom, M.; Rosenberg, I.; Ten Haken, R.K.

1983-01-01

A new technique is presented for determination of the effective point of measurement when cavity ionization chambers are used to measure the absorbed dose due to ionizing radiation in a dense medium. An algorithm is derived relating the effective point of measurement to the displacement correction factor. This algorithm relates variations of the displacement factor to the radiation field gradient. The technique is applied to derive the magnitudes of the corrections for several chambers in a p(66)Be(49) neutron therapy beam. 30 references, 4 figures, 1 table

Determination of correction and conversion factor of exposure rate generated Gamma spectrometer GR-320 to Victoreen data

International Nuclear Information System (INIS)

Supardjo-AS; Mappa, Djody-Rachim; Nasrun-Syamsul; Syamsul-Hadi

2000-01-01

Exposure rate data of Muria Peninsula were generated from Victoreen-491 measurement and calculation of radioelement content in soil which were measured by Exploranium GR-320, using IAEA formula. However those data are not be comparable so the exposure rate calculated from Gamma Spectrometer data necessarily to be corrected. The correction factor was determinate by measuring the exposure rate of at the NMDC's back yard selected location using Victoreen-491 and Gamma Spectrometer Exploranium GR-320 . Correction factor was created by comparing mean exposure rate data that calculated from 30 data measured by Gamma Spectrometer instrument and to those Victoreen's exposure rate. Conversion factor was gained from comparing of total count data of Gamma Spectrometer Exploranium GR-320 to Victoreen's exposure rate data. The correction factor of Exploranium GR-320's exposure rate is 0.34 μR/hours, and the conversion factor of total count is 0.0092 μR/hours per c/m. Deviation Victoreen 491 = 4.7 % and Gamma Spectrometer Exploranium GR-320 8.6 %

Validity and factor structure of the bodybuilding dependence scale.

Science.gov (United States)

Smith, D; Hale, B

2004-04-01

To investigate the factor structure, validity, and reliability of the bodybuilding dependence scale and to investigate differences in bodybuilding dependence between men and women and competitive and non-competitive bodybuilders. Seventy two male competitive bodybuilders, 63 female competitive bodybuilders, 87 male non-competitive bodybuilders, and 63 non-competitive female bodybuilders completed the bodybuilding dependence scale (BDS), the exercise dependence questionnaire (EDQ), and the muscle dysmorphia inventory (MDI). Confirmatory factor analysis of the BDS supported a three factor model of bodybuilding dependence, consisting of social dependence, training dependence, and mastery dependence (Q = 3.16, CFI = 0.98, SRMR = 0.04). Internal reliability of all three subscales was high (Cronbach's alpha = 0.92, 0.92, and 0.93 respectively). Significant (pbodybuilders scored significantly (pbodybuilders. However, there were no significant sex differences on any of the BDS subscales (p>0.05). The three factor BDS appears to be a reliable and valid measure of bodybuilding dependence. Symptoms of bodybuilding dependence are more prevalent in competitive bodybuilders than non-competitive ones, but there are no significant sex differences in bodybuilding dependence.

Use of eigenvectors in understanding and correcting storage ring orbits

International Nuclear Information System (INIS)

Friedman, A.; Bozoki, E.

1994-01-01

The response matrix A is defined by the equation X=AΘ, where Θ is the kick vector and X is the resulting orbit vector. Since A is not necessarily a symmetric or even a square matrix we symmetrize it by using A T A. Then we find the eigenvalues and eigenvectors of this A T A matrix. The physical interpretation of the eigenvectors for circular machines is discussed. The task of the orbit correction is to find the kick vector Θ for a given measured orbit vector X. We are presenting a method, in which the kick vector is expressed as linear combination of the eigenvectors. An additional advantage of this method is that it yields the smallest possible kick vector to correct the orbit. We will illustrate the application of the method to the NSLS X-ray and UV storage rings and the resulting measurements. It will be evident, that the accuracy of this method allows the combination of the global orbit correction and local optimization of the orbit for beam lines and insertion devices. The eigenvector decomposition can also be used for optimizing kick vectors, taking advantage of the fact that eigenvectors with corresponding small eigenvalue generate negligible orbit changes. Thus, one can reduce a kick vector calculated by any other correction method and still stay within the tolerance for orbit correction. The use of eigenvectors in accurately measuring the response matrix and the use of the eigenvalue decomposition orbit correction algorithm in digital feedback is discussed. (orig.)

Use of gradient dilution to flag and overcome matrix interferences in axial-viewing inductively coupled plasma-atomic emission spectrometry

International Nuclear Information System (INIS)

Cheung, Yan; Schwartz, Andrew J.; Hieftje, Gary M.

2014-01-01

Despite the undisputed power of inductively coupled plasma-atomic emission spectrometry (ICP-AES), its users still face serious challenges in obtaining accurate analytical results. Matrix interference is perhaps the most important challenge. Dilution of a matrix-containing sample is a common practice to reduce matrix interference. However, determining the optimal dilution factor requires tedious and time-consuming offline sample preparation, since emission lines and the effect of matrix interferences are affected differently by the dilution. The current study exploits this difference by employing a high-performance liquid chromatography gradient pump prior to the nebulizer to perform on-line mixing of a sample solution and diluent. Linear gradient dilution is performed on both the calibration standard and the matrix-containing sample. By ratioing the signals from two emission lines (from the same or different elements) as a function of dilution factor, the analyst can not only identify the presence of a matrix interference, but also determine the optimal dilution factor needed to overcome the interference. A ratio that does not change with dilution signals the absence of a matrix interference, whereas a changing ratio indicates the presence of an interference. The point on the dilution profile where the ratio stabilizes indicates the optimal dilution factor to correct the interference. The current study was performed on axial-viewing ICP-AES with o-xylene as the solvent

Applicability of perturbative QCD and NLO power corrections for the pion form factor

International Nuclear Information System (INIS)

Yeh Tsungwen

2002-01-01

As is well recognized, the asymptotic of the perturbative QCD prediction for the pion form factor is much smaller than the upper end of the data. We investigate this problem. We first evaluate the next-to-leading-order (NLO) power correction for the pion form factor. The corrected form factor contains nonperturbative parameters which are determined from a χ 2 fit to the data. Interpreting these parameters leads to the fact that the involved strong interaction coupling constant should be identified as an effective coupling constant under a nonperturbative QCD vacuum. If the scale associated with the effective coupling constant is identified as 2 Q 2 , then Q 2 , the momentum transfer square for the pion form factor to be measured, can have a value about 1 GeV 2 , and , the averaged momentum fraction variable, can locate around 0.5. This circumstance is consistent with the asymptotic model for the pion wave function

Sci—Fri AM: Mountain — 01: Validation of a new formulism and the related correction factors on output factor determination for small photon fields

Energy Technology Data Exchange (ETDEWEB)

Wang, Yizhen; Younge, Kelly; Nielsen, Michelle; Mutanga, Theodore [Peel Regional Cancer Center, Trillium Health Partners, Mississauga, ON (Canada); Cui, Congwu [Peel Regional Cancer Center, Trillium Health Partners, Mississauga, ON (Canada); Department of Radiation Oncology, University of Toronto, Toronto, ON (Canada); Das, Indra J. [Radiation Oncology Dept., Indiana University- School of Medicine, Indianapolis, IN (United States)

2014-08-15

Small field dosimetry measurements including output factors are difficult due to lack of charged-particle equilibrium, occlusion of the radiation source, the finite size of detectors, and non-water equivalence of detector components. With available detectors significant variations could be measured that will lead to incorrect delivered dose to patients. IAEA/AAPM have provided a framework and formulation to correct the detector response in small photon fields. Monte Carlo derived correction factors for some commonly used small field detectors are now available, however validation has not been performed prior to this study. An Exradin A16 chamber, EDGE detector and SFD detector were used to perform the output factor measurement for a series of conical fields (5–30mm) on a Varian iX linear accelerator. Discrepancies up to 20%, 10% and 6% were observed for 5, 7.5 and 10 mm cones between the initial output factors measured by the EDGE detector and the A16 ion chamber, while the discrepancies for the conical fields larger than 10 mm were less than 4%. After the application of the correction, the output factors agree well with each other to within 1%. Caution is needed when determining the output factors for small photon fields, especially for fields 10 mm in diameter or smaller. More than one type of detector should be used, each with proper corrections applied to the measurement results. It is concluded that with the application of correction factors to appropriately chosen detectors, output can be measured accurately for small fields.

A regularized matrix factorization approach to induce structured sparse-low-rank solutions in the EEG inverse problem

DEFF Research Database (Denmark)

Montoya-Martinez, Jair; Artes-Rodriguez, Antonio; Pontil, Massimiliano

2014-01-01

We consider the estimation of the Brain Electrical Sources (BES) matrix from noisy electroencephalographic (EEG) measurements, commonly named as the EEG inverse problem. We propose a new method to induce neurophysiological meaningful solutions, which takes into account the smoothness, structured...... sparsity, and low rank of the BES matrix. The method is based on the factorization of the BES matrix as a product of a sparse coding matrix and a dense latent source matrix. The structured sparse-low-rank structure is enforced by minimizing a regularized functional that includes the ℓ21-norm of the coding...... matrix and the squared Frobenius norm of the latent source matrix. We develop an alternating optimization algorithm to solve the resulting nonsmooth-nonconvex minimization problem. We analyze the convergence of the optimization procedure, and we compare, under different synthetic scenarios...

Polychoric/Tetrachoric Matrix or Pearson Matrix? A methodological study

Directory of Open Access Journals (Sweden)

Dominguez Lara, Sergio Alexis

2014-04-01

Full Text Available The use of product-moment correlation of Pearson is common in most studies in factor analysis in psychology, but it is known that this statistic is only applicable when the variables related are in interval scale and normally distributed, and when are used in ordinal data may to produce a distorted correlation matrix . Thus is a suitable option using polychoric/tetrachoric matrices in item-level factor analysis when the items are in level measurement nominal or ordinal. The aim of this study was to show the differences in the KMO, Bartlett`s Test and Determinant of the Matrix, percentage of variance explained and factor loadings in depression trait scale of Depression Inventory Trait - State and the Neuroticism dimension of the short form of the Eysenck Personality Questionnaire -Revised, regarding the use of matrices polychoric/tetrachoric matrices and Pearson. These instruments was analyzed with different extraction methods (Maximum Likelihood, Minimum Rank Factor Analysis, Unweighted Least Squares and Principal Components, keeping constant the rotation method Promin were analyzed. Were observed differences regarding sample adequacy measures, as well as with respect to the explained variance and the factor loadings, for solutions having as polychoric/tetrachoric matrix. So it can be concluded that the polychoric / tetrachoric matrix give better results than Pearson matrices when it comes to item-level factor analysis using different methods.

Radiative corrections for the leptonic pair production

Energy Technology Data Exchange (ETDEWEB)

Elend, H H

1971-01-01

The one-photon bremsstrahlung correction for symmetrical lepton pair production is newly calculated. For this, from all the Feynman diagrams, the subset is picked out for this process which essentially contributes to the symmetrical case. The matrix element square value for the chosen sub-set is expressed by the Bethe-Heitler matrix element square value provided with certain kinematic factors (Huld relationship), where a) a development after the energy of the Bremsquantum, assumed to be small, is carried out and the series is cut off after the second term beyond the infrared section, b) a high-energy approximation is made. Furthermore, c) the structure of the target nucleus and of the recoil transfered to it is neglected, d) the integration on the phase space of the bremsquantitum is carried out with a peaking approximation. All these approximations are individually discussed, and the validity limits which they set for the bremsstrahlung in the result are accurately given.

An improved correlated sampling method for calculating correction factor of detector

International Nuclear Information System (INIS)

Wu Zhen; Li Junli; Cheng Jianping

2006-01-01

In the case of a small size detector lying inside a bulk of medium, there are two problems in the correction factors calculation of the detectors. One is that the detector is too small for the particles to arrive at and collide in; the other is that the ratio of two quantities is not accurate enough. The method discussed in this paper, which combines correlated sampling with modified particle collision auto-importance sampling, and has been realized on the MCNP-4C platform, can solve these two problems. Besides, other 3 variance reduction techniques are also combined with correlated sampling respectively to calculate a simple calculating model of the correction factors of detectors. The results prove that, although all the variance reduction techniques combined with correlated sampling can improve the calculating efficiency, the method combining the modified particle collision auto-importance sampling with the correlated sampling is the most efficient one. (authors)

Matrix Intensification Affects Body and Physiological Condition of Tropical Forest-Dependent Passerines.

Directory of Open Access Journals (Sweden)

Justus P Deikumah

Full Text Available Matrix land-use intensification is a relatively recent and novel landscape change that can have important influences on the biota within adjacent habitat patches. While there are immediate local changes that it brings about, the influences on individual animals occupying adjacent habitats may be less evident initially. High-intensity land use could induce chronic stress in individuals in nearby remnants, leading ultimately to population declines. We investigated how physiological indicators and body condition measures of tropical forest-dependent birds differ between forest adjacent to surface mining sites and that near farmlands at two distances from remnant edge in southwest Ghana. We used mixed effects models of several condition indices including residual body mass and heterophil to lymphocyte (H/L ratios (an indicator of elevated chronic stress to explore the effect of matrix intensity on forest-dependent passerines classed as either sedentary area-sensitive habitat specialists or nomadic generalists. Individual birds occupying tropical forest remnants near surface mining sites were in poorer condition, as indicated by lower residual body mass and elevated chronic stress, compared to those in remnants near agricultural lands. The condition of the sedentary forest habitat specialists white-tailed alethe, Alethe diademata and western olive sunbird, Cyanomitra obscura was most negatively affected by high-intensity surface mining land-use adjacent to remnants, whereas generalist species were not affected. Land use intensification may set in train a new trajectory of faunal relaxation beyond that expected based on habitat loss alone. Patterns of individual condition may be useful in identifying habitats where species population declines may occur before faunal relaxation has concluded.

The S-matrix of superstring field theory

International Nuclear Information System (INIS)

Konopka, Sebastian

2015-01-01

We show that the classical S-matrix calculated from the recently proposed superstring field theories give the correct perturbative S-matrix. In the proof we exploit the fact that the vertices are obtained by a field redefinition in the large Hilbert space. The result extends to include the NS-NS subsector of type II superstring field theory and the recently found equations of motions for the Ramond fields. In addition, our proof implies that the S-matrix obtained from Berkovits’ WZW-like string field theory then agrees with the perturbative S-matrix to all orders.

First Industrial Tests of a Matrix Monitor Correction for the Differential Die-away Technique of Historical Waste Drums

International Nuclear Information System (INIS)

Antoni, Rodolphe; Passard, Christian; Perot, Bertrand; Batifol, Marc; Vandamme, Jean-Christophe; Grassi, Gabriele

2015-01-01

The fissile mass in radioactive waste drums filled with compacted metallic residues (spent fuel hulls and nozzles) produced at AREVA NC La Hague reprocessing plant is measured by neutron interrogation with the Differential Die-away measurement Technique (DDT). In the next years, old hulls and nozzles mixed with Ion-Exchange Resins will be measured. The ion-exchange resins increase neutron moderation in the matrix, compared to the waste measured in the current process. In this context, the Nuclear Measurement Laboratory (LMN) of CEA Cadarache has studied a matrix effect correction method, based on a drum monitor, namely a 3He proportional counter located inside the measurement cavity. After feasibility studies performed with LMN's PROMETHEE 6 laboratory measurement cell and with MCNPX simulations, this paper presents first experimental tests performed on the industrial ACC (hulls and nozzles compaction facility) measurement system. A calculation vs. experiment benchmark has been carried out by performing dedicated calibration measurements with a representative drum and 235 U samples. The comparison between calculation and experiment shows a satisfactory agreement for the drum monitor. The final objective of this work is to confirm the reliability of the modeling approach and the industrial feasibility of the method, which will be implemented on the industrial station for the measurement of historical wastes. (authors)

Convexity, gauge-dependence and tunneling rates

Energy Technology Data Exchange (ETDEWEB)

Plascencia, Alexis D.; Tamarit, Carlos [Institute for Particle Physics Phenomenology, Durham University,South Road, DH1 3LE (United Kingdom)

2016-10-19

We clarify issues of convexity, gauge-dependence and radiative corrections in relation to tunneling rates. Despite the gauge dependence of the effective action at zero and finite temperature, it is shown that tunneling and nucleation rates remain independent of the choice of gauge-fixing. Taking as a starting point the functional that defines the transition amplitude from a false vacuum onto itself, it is shown that decay rates are exactly determined by a non-convex, false vacuum effective action evaluated at an extremum. The latter can be viewed as a generalized bounce configuration, and gauge-independence follows from the appropriate Nielsen identities. This holds for any election of gauge-fixing that leads to an invertible Faddeev-Popov matrix.

Convexity, gauge-dependence and tunneling rates

International Nuclear Information System (INIS)

Plascencia, Alexis D.; Tamarit, Carlos

2016-01-01

We clarify issues of convexity, gauge-dependence and radiative corrections in relation to tunneling rates. Despite the gauge dependence of the effective action at zero and finite temperature, it is shown that tunneling and nucleation rates remain independent of the choice of gauge-fixing. Taking as a starting point the functional that defines the transition amplitude from a false vacuum onto itself, it is shown that decay rates are exactly determined by a non-convex, false vacuum effective action evaluated at an extremum. The latter can be viewed as a generalized bounce configuration, and gauge-independence follows from the appropriate Nielsen identities. This holds for any election of gauge-fixing that leads to an invertible Faddeev-Popov matrix.

Color correction pipeline optimization for digital cameras

Science.gov (United States)

Bianco, Simone; Bruna, Arcangelo R.; Naccari, Filippo; Schettini, Raimondo

2013-04-01

The processing pipeline of a digital camera converts the RAW image acquired by the sensor to a representation of the original scene that should be as faithful as possible. There are mainly two modules responsible for the color-rendering accuracy of a digital camera: the former is the illuminant estimation and correction module, and the latter is the color matrix transformation aimed to adapt the color response of the sensor to a standard color space. These two modules together form what may be called the color correction pipeline. We design and test new color correction pipelines that exploit different illuminant estimation and correction algorithms that are tuned and automatically selected on the basis of the image content. Since the illuminant estimation is an ill-posed problem, illuminant correction is not error-free. An adaptive color matrix transformation module is optimized, taking into account the behavior of the first module in order to alleviate the amplification of color errors. The proposed pipelines are tested on a publicly available dataset of RAW images. Experimental results show that exploiting the cross-talks between the modules of the pipeline can lead to a higher color-rendition accuracy.

A Transfer Learning Approach for Applying Matrix Factorization to Small ITS Datasets

Science.gov (United States)

Voß, Lydia; Schatten, Carlotta; Mazziotti, Claudia; Schmidt-Thieme, Lars

2015-01-01

Machine Learning methods for Performance Prediction in Intelligent Tutoring Systems (ITS) have proven their efficacy; specific methods, e.g. Matrix Factorization (MF), however suffer from the lack of available information about new tasks or new students. In this paper we show how this problem could be solved by applying Transfer Learning (TL),…

Path integral density matrix dynamics: a method for calculating time-dependent properties in thermal adiabatic and non-adiabatic systems.

Science.gov (United States)

Habershon, Scott

2013-09-14

We introduce a new approach for calculating quantum time-correlation functions and time-dependent expectation values in many-body thermal systems; both electronically adiabatic and non-adiabatic cases can be treated. Our approach uses a path integral simulation to sample an initial thermal density matrix; subsequent evolution of this density matrix is equivalent to solution of the time-dependent Schrödinger equation, which we perform using a linear expansion of Gaussian wavepacket basis functions which evolve according to simple classical-like trajectories. Overall, this methodology represents a formally exact approach for calculating time-dependent quantum properties; by introducing approximations into both the imaginary-time and real-time propagations, this approach can be adapted for complex many-particle systems interacting through arbitrary potentials. We demonstrate this method for the spin Boson model, where we find good agreement with numerically exact calculations. We also discuss future directions of improvement for our approach with a view to improving accuracy and efficiency.

Path integral density matrix dynamics: A method for calculating time-dependent properties in thermal adiabatic and non-adiabatic systems

International Nuclear Information System (INIS)

Habershon, Scott

2013-01-01

We introduce a new approach for calculating quantum time-correlation functions and time-dependent expectation values in many-body thermal systems; both electronically adiabatic and non-adiabatic cases can be treated. Our approach uses a path integral simulation to sample an initial thermal density matrix; subsequent evolution of this density matrix is equivalent to solution of the time-dependent Schrödinger equation, which we perform using a linear expansion of Gaussian wavepacket basis functions which evolve according to simple classical-like trajectories. Overall, this methodology represents a formally exact approach for calculating time-dependent quantum properties; by introducing approximations into both the imaginary-time and real-time propagations, this approach can be adapted for complex many-particle systems interacting through arbitrary potentials. We demonstrate this method for the spin Boson model, where we find good agreement with numerically exact calculations. We also discuss future directions of improvement for our approach with a view to improving accuracy and efficiency

Self-consistency corrections in effective-interaction calculations

International Nuclear Information System (INIS)

Starkand, Y.; Kirson, M.W.

1975-01-01

Large-matrix extended-shell-model calculations are used to compute self-consistency corrections to the effective interaction and to the linked-cluster effective interaction. The corrections are found to be numerically significant and to affect the rate of convergence of the corresponding perturbation series. The influence of various partial corrections is tested. It is concluded that self-consistency is an important effect in determining the effective interaction and improving the rate of convergence. (author)

Efficient fully 3D list-mode TOF PET image reconstruction using a factorized system matrix with an image domain resolution model

International Nuclear Information System (INIS)

Zhou, Jian; Qi, Jinyi

2014-01-01

A factorized system matrix utilizing an image domain resolution model is attractive in fully 3D time-of-flight PET image reconstruction using list-mode data. In this paper, we study a factored model based on sparse matrix factorization that is comprised primarily of a simplified geometrical projection matrix and an image blurring matrix. Beside the commonly-used Siddon’s ray-tracer, we propose another more simplified geometrical projector based on the Bresenham’s ray-tracer which further reduces the computational cost. We discuss in general how to obtain an image blurring matrix associated with a geometrical projector, and provide theoretical analysis that can be used to inspect the efficiency in model factorization. In simulation studies, we investigate the performance of the proposed sparse factorization model in terms of spatial resolution, noise properties and computational cost. The quantitative results reveal that the factorization model can be as efficient as a non-factored model, while its computational cost can be much lower. In addition we conduct Monte Carlo simulations to identify the conditions under which the image resolution model can become more efficient in terms of image contrast recovery. We verify our observations using the provided theoretical analysis. The result offers a general guide to achieve the optimal reconstruction performance based on a sparse factorization model with an image domain resolution model. (paper)

Long-term correction of canine hemophilia B by gene transfer of blood coagulation factor IX mediated by adeno-associated viral vector.

Science.gov (United States)

Herzog, R W; Yang, E Y; Couto, L B; Hagstrom, J N; Elwell, D; Fields, P A; Burton, M; Bellinger, D A; Read, M S; Brinkhous, K M; Podsakoff, G M; Nichols, T C; Kurtzman, G J; High, K A

1999-01-01

Hemophilia B is a severe X-linked bleeding diathesis caused by the absence of functional blood coagulation factor IX, and is an excellent candidate for treatment of a genetic disease by gene therapy. Using an adeno-associated viral vector, we demonstrate sustained expression (>17 months) of factor IX in a large-animal model at levels that would have a therapeutic effect in humans (up to 70 ng/ml, adequate to achieve phenotypic correction, in an animal injected with 8.5x10(12) vector particles/kg). The five hemophilia B dogs treated showed stable, vector dose-dependent partial correction of the whole blood clotting time and, at higher doses, of the activated partial thromboplastin time. In contrast to other viral gene delivery systems, this minimally invasive procedure, consisting of a series of percutaneous intramuscular injections at a single timepoint, was not associated with local or systemic toxicity. Efficient gene transfer to muscle was shown by immunofluorescence staining and DNA analysis of biopsied tissue. Immune responses against factor IX were either absent or transient. These data provide strong support for the feasibility of the approach for therapy of human subjects.

Matrix-Dependent Regulation of AKT in Hepsin-Overexpressing PC3 Prostate Cancer Cells12

Science.gov (United States)

Wittig-Blaich, Stephanie M; Kacprzyk, Lukasz A; Eismann, Thorsten; Bewerunge-Hudler, Melanie; Kruse, Petra; Winkler, Eva; Strauss, Wolfgang S L; Hibst, Raimund; Steiner, Rudolf; Schrader, Mark; Mertens, Daniel; Sültmann, Holger; Wittig, Rainer

2011-01-01

The serine-protease hepsin is one of the most prominently overexpressed genes in human prostate carcinoma. Forced expression of the enzyme in mice prostates is associated with matrix degradation, invasive growth, and prostate cancer progression. Conversely, hepsin overexpression in metastatic prostate cancer cell lines was reported to induce cell cycle arrest and reduction of invasive growth in vitro. We used a system for doxycycline (dox)-inducible target gene expression in metastasis-derived PC3 cells to analyze the effects of hepsin in a quantitative manner. Loss of viability and adhesion correlated with hepsin expression levels during anchorage-dependent but not anchorage-independent growth. Full expression of hepsin led to cell death and detachment and was specifically associated with reduced phosphorylation of AKT at Ser473, which was restored by growth on matrix derived from RWPE1 normal prostatic epithelial cells. In the chorioallantoic membrane xenograft model, hepsin overexpression in PC3 cells reduced the viability of tumors but did not suppress invasive growth. The data presented here provide evidence that elevated levels of hepsin interfere with cell adhesion and viability in the background of prostate cancer as well as other tissue types, the details of which depend on the microenvironment provided. Our findings suggest that overexpression of the enzyme in prostate carcinogenesis must be spatially and temporally restricted for the efficient development of tumors and metastases. PMID:21750652

How important is self-consistency for the dDsC density dependent dispersion correction?

Energy Technology Data Exchange (ETDEWEB)

Brémond, Éric; Corminboeuf, Clémence, E-mail: clemence.corminboeuf@epfl.ch [Laboratory for Computational Molecular Design, Institut des Sciences et Ingénierie Chimiques, Ecole Polytechnique Fédérale de Lausanne, CH-1015 Lausanne (Switzerland); Golubev, Nikolay [Laboratory for Computational Molecular Design, Institut des Sciences et Ingénierie Chimiques, Ecole Polytechnique Fédérale de Lausanne, CH-1015 Lausanne (Switzerland); Department of Chemistry, M. V. Lomonosov Moscow State University, Moscow 119991 (Russian Federation); Steinmann, Stephan N., E-mail: sns25@duke.edu [Laboratory for Computational Molecular Design, Institut des Sciences et Ingénierie Chimiques, Ecole Polytechnique Fédérale de Lausanne, CH-1015 Lausanne (Switzerland); Department of Chemistry, Duke University, Durham, North Carolina 27708 (United States)

2014-05-14

The treatment of dispersion interactions is ubiquitous but computationally demanding for seamless ab initio approaches. A highly popular and simple remedy consists in correcting for the missing interactions a posteriori by adding an attractive energy term summed over all atom pairs to standard density functional approximations. These corrections were originally based on atom pairwise parameters and, hence, had a strong touch of empiricism. To overcome such limitations, we recently proposed a robust system-dependent dispersion correction, dDsC, that is computed from the electron density and that provides a balanced description of both weak inter- and intramolecular interactions. From the theoretical point of view and for the sake of increasing reliability, we here verify if the self-consistent implementation of dDsC impacts ground-state properties such as interaction energies, electron density, dipole moments, geometries, and harmonic frequencies. In addition, we investigate the suitability of the a posteriori scheme for molecular dynamics simulations, for which the analysis of the energy conservation constitutes a challenging tests. Our study demonstrates that the post-SCF approach in an excellent approximation.

Gauge dependence of world lines and invariance of the S-matrix in relativistic classical mechanics

International Nuclear Information System (INIS)

Molotkov, V.V.; Todorov, I.T.

1980-07-01

The notion of world lines is studied in the constraint Hamiltonian formulation of relativistic point particle dynamics. The particle world lines are shown to depend in general (in the presence of interaction) on the choice of the equal-time hyperplane (the only exception being the elastic scattering of rigid balls). However, the relative motion of a two-particle system and the (classical) S-matrix are indepent of this choice. (author)

Positive semidefinite tensor factorizations of the two-electron integral matrix for low-scaling ab initio electronic structure.

Science.gov (United States)

Hoy, Erik P; Mazziotti, David A

2015-08-14

Tensor factorization of the 2-electron integral matrix is a well-known technique for reducing the computational scaling of ab initio electronic structure methods toward that of Hartree-Fock and density functional theories. The simplest factorization that maintains the positive semidefinite character of the 2-electron integral matrix is the Cholesky factorization. In this paper, we introduce a family of positive semidefinite factorizations that generalize the Cholesky factorization. Using an implementation of the factorization within the parametric 2-RDM method [D. A. Mazziotti, Phys. Rev. Lett. 101, 253002 (2008)], we study several inorganic molecules, alkane chains, and potential energy curves and find that this generalized factorization retains the accuracy and size extensivity of the Cholesky factorization, even in the presence of multi-reference correlation. The generalized family of positive semidefinite factorizations has potential applications to low-scaling ab initio electronic structure methods that treat electron correlation with a computational cost approaching that of the Hartree-Fock method or density functional theory.