MASER OBSERVATIONS OF WESTERLUND 1 AND COMPREHENSIVE CONSIDERATIONS ON MASER PROPERTIES OF RED SUPERGIANTS ASSOCIATED WITH MASSIVE CLUSTERS

Energy Technology Data Exchange (ETDEWEB)

Fok, Thomas K. T.; Nakashima, Jun-ichi; Yung, Bosco H. K.; Hsia, Chih-Hao [Department of Physics, University of Hong Kong, Pokfulam Road (Hong Kong); Deguchi, Shuji, E-mail: junichi@hku.hk [Nobeyama Radio Observatory, National Astronomical Observatory of Japan, Minamimaki, Minamisaku, Nagano 384-1305 (Japan)

2012-11-20

We report the results of Australia Telescope Compact Array observations of the Westerlund 1 (Wd1) region in the SiO v = 1, J = 1-0, and H{sub 2}O 6{sub 16}-5{sub 23} maser lines, and we also report the analysis of maser properties of red supergiants (RSGs) associated with six massive clusters including Wd1. The primary purpose of this research is to explore possibilities of using maser emission for investigating the nature of massive clusters and associated RSGs. The SiO v = 1, J = 1-0, and H{sub 2}O 6{sub 16}-5{sub 23} maser lines are detected toward two of four known RSGs in Wd1. The large velocity ranges of maser emission are consistent with the RSG status. RSGs with maser emission tend to exhibit redder log (F {sub 21}/F {sub 12}) and [K-12.13] colors compared to RSGs with no maser emission. The mass-loss rates derived from dust radiative transfer modeling suggest that RSGs with maser emission tend to exhibit larger mass-loss rates compared to RSGs with no maser emission. In an extended sample of 57 RSGs in six massive clusters, detections in the SiO line tend to homogeneously distribute in absolute luminosity L, whereas those in the H{sub 2}O line tend to distribute in a region with large L values.

Maser observation in VY CMa with VERA

Science.gov (United States)

Choi, Yoon Kyung

We present the results of multi-epoch VERA (VLBI Exploration of Radio Astrometry) observations of H2O masers at 22 GHz and ^28SiO masers at 43 GHz in the supergiant VY Canis Majoris (hereafter, VY CMa). We estimate the inner motion of H2O masers over 6 months and that of SiO masers over 1 month. Using the inner motion, we calculated the statistical parallax of VY CMa. The size of the emitting region for ^28SiO masers is R_SiO ~1.81-2.89 R_* and it is consistent with the previous study.

Water masers in NGC7538 region

Science.gov (United States)

Kameya, Osamu

We observed H2O masers towards NGC7538 molecular-cloud core using VERA (VLBI Experiment of Radio Astrometry). This region is in the Perseus arm at a distance of about 2.7 kpc and is famous for its multiple, massive star formation. There are three areas there, N(IRS1-3), E(IRS9), and S(IRS11), each having a strong IR source(s), ultra-compact HII region(s), bipolar outflow, high-density core, and OH/H2O/CH3OH masers. We made differential VLBI observations towards the NGC7538 H2O maser sources at N and S and a reference source, Cepheus A H2O maser, simultaneously. The Cepheus A region is separated by 2 degrees from the NGC7538 region. The positions of H2O masers in N and S regions, distributed around the ultra-compact HII regions, are basically consistent with those found by means of interferometric observations of past 29 years. The masers may come from interface regions between the ultra-compact HII regions and the environments of dense molecular gas.

Maser Emission Associated with Young High Mass Stars

Science.gov (United States)

Mahmoud, Khaled Abdalla Edris

In this work the maser emission has been used to study the very early stage evolution of the young stars. The maser emission of OH molecule was searched for towards a sample of high mass protostellar objects using the Nançay and GBT telescopes. The sample of objects searched was selected to contain very young forming high mass stars. The results of this survey have been compared with previous H2O and CH3OH masers observations. Then MERLIN has been used to map the OH as well as H2O and CH3OH masers towards one of these sources in high angular resolution. The survey detected OH maser emission towards 63 objects with 37 new detections. There are 56 star forming regions and 7 OH/IR candidates. The detection of OH masers towards 26% of a sample of 217 sources should remove any doubt about the existence of OH maser emission towards these objects of this early evolutionary stage. Nearly half of the detected sources have OH fluxes rates and velocity range support the spatial association of OH and class II CH3OH masers as suggested by Caswell et al. [1995] and modelled by Cragg et al. [2002]. IRAS20126+4104 was mapped in the OH, water and methanol masers using MERLIN. The 1665-MHz OH, 22-GHz H2O and 6.7-GHz CH3OH masers are detected and all originate very close to the central source. The OH and methanol masers appear to trace part of the circumstellar disk around the central source. The positions and velocities of the OH masers are consistent with Keplerian rotation around a central mass of ˜5Msun. The water masers are offset from the OH and CH3OH masers and have significantly changed since they were last observed, but still appear to be associated outflow from the source. All the OH masers components are circular polarized, in some cases reaching 100 percent while some OH components also have low levels of linear polarization. We identified one Zeeman pair and the splitting of this pair indicate the presence of a magnetic field of strength ˜11 mG within ˜0.5" (850 AU

Characteristics of infrared point sources associated with OH masers

International Nuclear Information System (INIS)

Mu Jimang; Esimbek, Jarken; Zhou Jianjun; Zhang Haijuan

2010-01-01

We collect 3249 OH maser sources from the literature published up to April 2007, and compile a new catalog of OH masers. We look for the exciting sources of these masers and their infrared properties from IRAS and MSX data, and make a statistical study. MSX sources associated with stellar 1612 MHz OH masers are located mainly above the blackbody line; this is caused by the dust absorption of stellar envelopes, especially in the MSX A band. The mid-IR sources associated with stellar OH masers are concentrated in a small region in an [A]-[D] vs. [A]-[E] diagram with a small fraction of contamination; this gives us a new criterion to search for new stellar OH masers and distinguish stellar masers from unknown types of OH masers. IR sources associated with 1612 MHz stellar OH masers show an expected result: the average flux of sources with F60 > F25 increases with increasing wavelength, while those with F60 F25.

New water masers in the Southern hemisphere

International Nuclear Information System (INIS)

Scalise Junior, E.; Vale, J.L.M. do

1988-01-01

A search for water vapor maser have been conducted in the direction of selected strong point sources detected by the Infrared Astronomical Satellite - IRAS. 325 points were observed and 18 water maser sources were detected. The detection rate was 5,6%. The new sources are discussed and compared with the known galactic masers. (author) [pt

Continuous-wave room-temperature diamond maser

Science.gov (United States)

Breeze, Jonathan D.; Salvadori, Enrico; Sathian, Juna; Alford, Neil Mcn.; Kay, Christopher W. M.

2018-03-01

The maser—the microwave progenitor of the optical laser—has been confined to relative obscurity owing to its reliance on cryogenic refrigeration and high-vacuum systems. Despite this, it has found application in deep-space communications and radio astronomy owing to its unparalleled performance as a low-noise amplifier and oscillator. The recent demonstration of a room-temperature solid-state maser that utilizes polarized electron populations within the triplet states of photo-excited pentacene molecules in a p-terphenyl host paves the way for a new class of maser. However, p-terphenyl has poor thermal and mechanical properties, and the decay rates of the triplet sublevel of pentacene mean that only pulsed maser operation has been observed in this system. Alternative materials are therefore required to achieve continuous emission: inorganic materials that contain spin defects, such as diamond and silicon carbide, have been proposed. Here we report a continuous-wave room-temperature maser oscillator using optically pumped nitrogen–vacancy defect centres in diamond. This demonstration highlights the potential of room-temperature solid-state masers for use in a new generation of microwave devices that could find application in medicine, security, sensing and quantum technologies.

A New 95 GHz Methanol Maser Catalog. I. Data

Energy Technology Data Exchange (ETDEWEB)

Yang, Wenjin; Xu, Ye; Lu, Dengrong; Ju, Binggang; Li, Yingjie [Purple Mountain Observatory, Chinese Academy of Science, Nanjing 210008 (China); Chen, Xi [Center for Astrophysics, GuangZhou University, Guangzhou 510006 (China); Ellingsen, Simon P., E-mail: wjyang@pmo.ac.cn, E-mail: xuye@pmo.ac.cn, E-mail: chenxi@shao.ac.cn [School of Physical Sciences, University of Tasmania, Hobart, Tasmania (Australia)

2017-08-01

The Purple Mountain Observatory 13.7 m radio telescope has been used to search for 95 GHz (8{sub 0}–7{sub 1}A{sup +}) class I methanol masers toward 1020 Bolocam Galactic Plane Survey (BGPS) sources, leading to 213 detections. We have compared the line width of the methanol and HCO{sup +} thermal emission in all of the methanol detections, and on that basis, we find that 205 of the 213 detections are very likely to be masers. This corresponds to an overall detection rate of 95 GHz methanol masers toward our BGPS sample of 20%. Of the 205 detected masers, 144 (70%) are new discoveries. Combining our results with those of previous 95 GHz methanol maser searches, a total of 481 95 GHz methanol masers are now known. We have compiled a catalog listing the locations and properties of all known 95 GHz methanol masers.

Single-cell 5hmC sequencing reveals chromosome-wide cell-to-cell variability and enables lineage reconstruction

NARCIS (Netherlands)

Mooijman, Dylan; Dey, Siddharth S; Boisset, Jean-Charles; Crosetto, Nicola; van Oudenaarden, Alexander

2016-01-01

The epigenetic DNA modification 5-hydroxymethylcytosine (5hmC) has crucial roles in development and gene regulation. Quantifying the abundance of this epigenetic mark at the single-cell level could enable us to understand its roles. We present a single-cell, genome-wide and strand-specific 5hmC

The Hybrid Monte Carlo (HMC) method and dynamic fermions

International Nuclear Information System (INIS)

Amaral, Marcia G. do

1994-01-01

Nevertheless the Monte Carlo method has been extensively used in the simulation of many types of theories, the successful application has been established only for models containing boson fields. With the present computer generation, the development of faster and efficient algorithms became necessary and urgent. This paper studies the HMC and the dynamic fermions

H2O masers in star-forming regions

International Nuclear Information System (INIS)

Downes, D.

1985-01-01

Water vapour near star forming regions was first detected by Cheung et al. (1969) and shortly thereafter was recognised to be maser emission. In spite of this 15 year history of H 2 O observations, the problem of interpreting such strong H 2 O masers as W49 and Orion is still very acute. Not one of the models now available can explain in an unconstrained fashion why a very large maser flux can emanate from clouds of such small size. Whereas some models proposed to explain OH masers have retained their plausibility under the pressure of new observations, H 2 O models have not. The author outlines the background of the H 2 O problem, stating that the strongest of the masers discovered are still not satisfactorily explained today. (Auth.)

A model for extremely powerful extragalactic water masers

Energy Technology Data Exchange (ETDEWEB)

Wu, Ying-Cheng; Alcock, C.

1988-08-01

The reasons for the differences between extremely powerful extragalatic water masers (EPEWMs) and strong Galactic H/sub 2/O masers are discussed. This model quite successfully explains many important characteristics of EPEWMs; the rapid time variations, the broad range and random velocity distribution, the extremely high luminosities, the various heights or widths of features in spectra, the strong infrared radiation from the galaxies, how an active nucleus contributes to an EPEWM, how some parts of EPEWMs producing strong features are pumped, why this pump mechanism can work, and why EPEWMs are different from strong Galactic H/sub 2/O masers. Recent observations of extragalactic water masers which have extremely high luminosities raise the possibility that the stimulated emission rate in the maser emission line in these regions is much higher than in Galactic masers. It is possible that the local stimulated emission rate exceeds the local bandwidth for the radiation. In this case the standard expression relating the photon emission rate to the profile averaged mean intensity does not apply. A new expression for the photon emission rate is derived.

A model for extremely powerful extragalactic water masers

International Nuclear Information System (INIS)

Wu, Ying-Cheng; Alcock, C.

1988-08-01

The reasons for the differences between extremely powerful extragalatic water masers (EPEWMs) and strong Galactic H 2 O masers are discussed. This model quite successfully explains many important characteristics of EPEWMs; the rapid time variations, the broad range and random velocity distribution, the extremely high luminosities, the various heights or widths of features in spectra, the strong infrared radiation from the galaxies, how an active nucleus contributes to an EPEWM, how some parts of EPEWMs producing strong features are pumped, why this pump mechanism can work, and why EPEWMs are different from strong Galactic H 2 O masers. Recent observations of extragalactic water masers which have extremely high luminosities raise the possibility that the stimulated emission rate in the maser emission line in these regions is much higher than in Galactic masers. It is possible that the local stimulated emission rate exceeds the local bandwidth for the radiation. In this case the standard expression relating the photon emission rate to the profile averaged mean intensity does not apply. A new expression for the photon emission rate is derived

NEW MASER EMISSION FROM NONMETASTABLE AMMONIA IN NGC 7538. II. GREEN BANK TELESCOPE OBSERVATIONS INCLUDING WATER MASERS

Energy Technology Data Exchange (ETDEWEB)

Hoffman, Ian M. [St. Paul' s School, Concord, NH 03301 (United States); Seojin Kim, Stella, E-mail: ihoffman@sps.edu [Current address: Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139 (United States)

2011-12-15

We present new maser emission from {sup 14}NH{sub 3} (9,6) in NGC 7538. Our observations include the known spectral features near v{sub LSR} = -60 km s{sup -1} and -57 km s{sup -1} and several more features extending to -46 km s{sup -1}. In three epochs of observation spanning two months we do not detect any variability in the ammonia masers, in contrast to the >10-fold variability observed in other {sup 14}NH{sub 3} (9,6) masers in the Galaxy over comparable timescales. We also present observations of water masers in all three epochs for which emission is observed over the velocity range -105 km s{sup -1} < v{sub LSR} < -4 km s{sup -1}, including the highest velocity water emission yet observed from NGC 7538. Of the remarkable number of maser species in IRS 1, H{sub 2}O and, now, {sup 14}NH{sub 3} are the only masers known to exhibit emission outside of the velocity range -62 km s{sup -1} < v{sub LSR} < -51 km s{sup -1}. However, we find no significant intensity or velocity correlations between the water emission and ammonia emission. We also present a non-detection in the most sensitive search to date toward any source for emission from the CC{sup 32}S and CC{sup 34}S molecules, indicating an age greater than Almost-Equal-To 10{sup 4} yr for IRS 1-3. We discuss these findings in the context of embedded stellar cores and recent models of the region.

Magnetosphere as an Alfven maser

International Nuclear Information System (INIS)

Trakhtengerts, V.Yu.

1979-01-01

The Earth magnetosphere is considered as an Alfven maser. The operation mechanism of such a maser is duscussed. The main fact of this mechanism is ''overpopulation'' of the Earth radiation belt with particles moving with cross velocities. The cross velocity particles excess results in the excitation of cyclotron instability in the radiation belt and in the self-arbitrary increase of Alfven waves. At late the theory of cyclotron instability of radiation belts has been universally developed. On the basis of ideas on magnetosphere maser on cyclotron resonance it was possible to explain many geophysical phenomena such as periodical spillings out of particles from the radiation belts, pulsing polar lights, oscillations of magnetic force tubes etc. It is proposed to carry out active cosmic experiments to understand deeper the processes occuring in radiation belts

Unbiased water and methanol maser surveys of NGC 1333

Energy Technology Data Exchange (ETDEWEB)

Lyo, A-Ran; Kim, Jongsoo; Byun, Do-Young; Lee, Ho-Gyu, E-mail: arl@kasi.re.kr [Korea Astronomy and Space Science Institute, 776, Daedeokdae-ro Yuseong-gu, Daejeon 305-348 (Korea, Republic of)

2014-11-01

We present the results of unbiased 22 GHz H{sub 2}O water and 44 GHz class I CH{sub 3}OH methanol maser surveys in the central 7' × 10' area of NGC 1333 and two additional mapping observations of a 22 GHz water maser in a ∼3' × 3' area of the IRAS4A region. In the 22 GHz water maser survey of NGC 1333 with a sensitivity of σ ∼ 0.3 Jy, we confirmed the detection of masers toward H{sub 2}O(B) in the region of HH 7-11 and IRAS4B. We also detected new water masers located ∼20'' away in the western direction of IRAS4B or ∼25'' away in the southern direction of IRAS4A. We could not, however, find young stellar objects or molecular outflows associated with them. They showed two different velocity components of ∼0 and ∼16 km s{sup –1}, which are blue- and redshifted relative to the adopted systemic velocity of ∼7 km s{sup –1} for NGC 1333. They also showed time variabilities in both intensity and velocity from multi-epoch observations and an anti-correlation between the intensities of the blue- and redshifted velocity components. We suggest that the unidentified power source of these masers might be found in the earliest evolutionary stage of star formation, before the onset of molecular outflows. Finding this kind of water maser is only possible through an unbiased blind survey. In the 44 GHz methanol maser survey with a sensitivity of σ ∼ 0.5 Jy, we confirmed masers toward IRAS4A2 and the eastern shock region of IRAS2A. Both sources are also detected in 95 and 132 GHz methanol maser lines. In addition, we had new detections of methanol masers at 95 and 132 GHz toward IRAS4B. In terms of the isotropic luminosity, we detected methanol maser sources brighter than ∼5 × 10{sup 25} erg s{sup –1} from our unbiased survey.

ACCURATE OH MASER POSITIONS FROM THE SPLASH PILOT REGION

Energy Technology Data Exchange (ETDEWEB)

Qiao, Hai-Hua; Shen, Zhi-Qiang [Shanghai Astronomical Observatory, Chinese Academy of Sciences, 80 Nandan Road, Shanghai, 200030 (China); Walsh, Andrew J.; Jordan, Christopher H. [International Centre for Radio Astronomy Research, Curtin University, GPO Box U1987, Perth WA 6845 (Australia); Green, James A. [CSIRO Astronomy and Space Science, Australia Telescope National Facility, PO Box 76, Epping, NSW 2121 (Australia); Breen, Shari L. [Sydney Institute for Astronomy (SIfA), School of Physics, University of Sydney, NSW 2006 (Australia); Dawson, J. R. [Department of Physics and Astronomy and MQ Research Centre in Astronomy, Astrophysics and Astrophotonics, Macquarie University, NSW 2109 (Australia); Ellingsen, Simon P. [School of Physical Sciences, Private Bag 37,University of Tasmania, Hobart 7001, TAS (Australia); Gómez, José F. [Instituto de Astrofísica de Andalucía, CSIC, Glorieta de la Astronomía s/n, E-18008, Granada (Spain); Lowe, Vicki; Jones, Paul A., E-mail: qiaohh@shao.ac.cn [Department of Astrophysics and Optic, School of Physics, University of New South Wales, Sydney, NSW 2052 (Australia)

2016-12-01

We report on high spatial resolution observations, using the Australia Telescope Compact Array (ATCA), of ground-state OH masers. These observations were carried out toward 196 pointing centers previously identified in the Southern Parkes Large-Area Survey in Hydroxyl (SPLASH) pilot region, between Galactic longitudes of 334° and 344° and Galactic latitudes of −2° and +2°. Supplementing our data with data from the MAGMO (Mapping the Galactic Magnetic field through OH masers) survey, we find maser emission toward 175 of the 196 target fields. We conclude that about half of the 21 nondetections were due to intrinsic variability. Due to the superior sensitivity of the followup ATCA observations, and the ability to resolve nearby sources into separate sites, we have identified 215 OH maser sites toward the 175 fields with detections. Among these 215 OH maser sites, 111 are new detections. After comparing the positions of these 215 maser sites to the literature, we identify 122 (57%) sites associated with evolved stars (one of which is a planetary nebula), 64 (30%) with star formation, two sites with supernova remnants, and 27 (13%) of unknown origin. The infrared colors of evolved star sites with symmetric maser profiles tend to be redder than those of evolved star sites with asymmetric maser profiles, which may indicate that symmetric sources are generally at an earlier evolutionary stage.

FAST Maser Surveys J. S. Zhang

Indian Academy of Sciences (India)

nese institutions and industries and the first light is expected to be in 2016. FAST ... tem, extragalactic pulsar, high redshift megamasers and radio signals from exoplan- ets (Nan et al. ... Since OH maser emission was detected in galactic molecular clouds in 1960s. (Weaver ... OH maser (other three lines are weak or absent).

FAST Maser Surveys J. S. Zhang

Indian Academy of Sciences (India)

are found to be closely associated with ultra-compact HII regions, embedded IR sources, hot molecular cores, Herbig-Haro objects, and outflows etc., which can be used to probe star formation. And OH masers in circumstellar envelopes (cir- cumstellar masers) were found to be related to outflowing and cool winds from the.

UNUSUAL SHOCK-EXCITED OH MASER EMISSION IN A YOUNG PLANETARY NEBULA

Energy Technology Data Exchange (ETDEWEB)

Qiao, Hai-Hua; Shen, Zhi-Qiang [Shanghai Astronomical Observatory, Chinese Academy of Sciences, 80 Nandan Rd, Shanghai, 200030 (China); Walsh, Andrew J. [International Centre for Radio Astronomy Research, Curtin University, GPO Box U1987, Perth WA 6845 (Australia); Gómez, José F. [Instituto de Astrofísica de Andalucía, CSIC, Glorieta de la Astronomía s/n, E-18008, Granada (Spain); Imai, Hiroshi [Department of Physics and Astronomy, Graduate School of Science and Engineering, Kagoshima University, 1-21-35 Korimoto, Kagoshima 890-0065 (Japan); Green, James A. [SKA Organisation, Jodrell Bank Observatory, Lower Withington, Macclesfield, Cheshire SK11 9DL (United Kingdom); Dawson, Joanne R. [Department of Physics and Astronomy and MQ Research Centre in Astronomy, Astrophysics and Astrophotonics, Macquarie University, NSW 2109 (Australia); Ellingsen, Simon P. [School of Physical Sciences, Private Bag 37, University of Tasmania, Hobart 7001, TAS (Australia); Breen, Shari L. [Australia Telescope National Facility, CSIRO Astronomy and Space Science, P.O. Box 76, Epping, NSW 1710 (Australia); Jones, Paul A.; Cunningham, Maria R. [School of Physics, University of New South Wales, Sydney, NSW 2052 (Australia); Gibson, Steven J., E-mail: haihua.qiao@curtin.edu.au [Department of Physics and Astronomy, Western Kentucky University, 1906 College Heights Blvd, Bowling Green, KY 42101 (United States)

2016-01-20

We report on OH maser emission toward G336.644−0.695 (IRAS 16333−4807), which is a H{sub 2}O maser-emitting Planetary Nebula (PN). We have detected 1612, 1667, and 1720 MHz OH masers at two epochs using the Australia Telescope Compact Array, hereby confirming it as the seventh known case of an OH-maser-emitting PN. This is only the second known PN showing 1720 MHz OH masers after K 3−35 and the only evolved stellar object with 1720 MHz OH masers as the strongest transition. This PN is one of a group of very young PNe. The 1612 MHz and 1667 MHz masers are at a similar velocity to the 22 GHz H{sub 2}O masers, whereas the 1720 MHz masers show a variable spectrum, with several components spread over a higher velocity range (up to 36 km s{sup −1}). We also detect Zeeman splitting in the 1720 MHz transition at two epochs (with field strengths of ∼2 to ∼10 mG), which suggests the OH emission at 1720 MHz is formed in a magnetized environment. These 1720 MHz OH masers may trace short-lived equatorial ejections during the formation of the PN.

An Improved X-Band Maser System for Deep Space Network Applications

Science.gov (United States)

Britcliffe, M.; Hanson, T.; Fernandez, J.

2000-01-01

An 8450-MHz (X-band) maser system utilizing a commercial Gifford--McMahon (GM) closed-cycle cryocooler (CCR) was designed, fabricated, and demonstrated. The CCR system was used to cool a maser operating at 8450 MHz. The prototype GM CCR system meets or exceeds all Deep Space Network requirements for maser performance. The two-stage GM CCR operates at 4.2 K; for comparison, the DSN's current three-stage cryocooler, which uses a Joule--Thompson cooling stage in addition to GM cooling, operates at 4.5 K. The new CCR withstands heat loads of 1.5 W at 4.2 K as compared to 1 W at 4.5 K for the existing DSN cryocooler used for cooling masers. The measured noise temperature, T_e, of the maser used for these tests is defined at the ambient connection to the antenna feed system. The T_e measured 5.0 K at a CCR temperature of 4.5 K, about 1.5 K higher than the noise temperature of a typical DSN Block II-A X-band traveling-wave maser (TWM). Reducing the temperature of the CCR significantly lowers the maser noise temperature and increases maser gain and bandwidth. The new GM CCR gives future maser systems significant operational advantages, including reduced maintenance time and logistics requirements. The results of a demonstration of this new system are presented. Advantages of using a GM-cooled maser and the effects of the reduced CCR temperature on maser performance are discussed.

Millimetre wavelength methanol masers survey towards massive star forming regions

Science.gov (United States)

Umemoto, T.; Mochizuki, N.; Shibata, K. M.; Roh, D.-G.; Chung, H.-S.

2007-03-01

We present the results of a mm wavelength methanol maser survey towards massive star forming regions. We have carried out Class II methanol maser observations at 86.6 GHz, 86.9 GHz and 107.0 GHz, simultaneously, using the Nobeyama 45 m telescope. We selected 108 6.7 GHz methanol maser sources with declinations above -25 degrees and fluxes above 20 Jy. The detection limit of maser observations was ~3 Jy. Of the 93 sources surveyed so far, we detected methanol emission in 25 sources (27%) and “maser” emission in nine sources (10%), of which thre “maser” sources are new detections. The detection rate for maser emission is about half that of a survey of the southern sky (Caswell et al. 2000). There is a correlation between the maser flux of 107 GHz and 6.7 GHz/12 GHz emission, but no correlation with the “thermal” (non maser) emission. From results of other molecular line observations, we found that the sources with methanol emission show higher gas temperatures and twice the detection rate of SiO emission. This may suggest that dust evaporation and destruction by shock are responsible for the high abundance of methanol molecules, one of the required physical conditions for maser emission.

A new maser effect in plasma turbulence

International Nuclear Information System (INIS)

Nambu, M.

1983-01-01

The present state of understanding of a new maser effect is reviewed. The new maser effect, the idea that the resonant electrons in a turbulent plasma can radiate amplified electromagnetic radiation, does not require population inversion of electrons. The new maser effect always coexists with Landau (or cyclotron) damping; thus it is a fundamental effect in plasma turbulence. In nuclear fusion, magnetic confinement will be at a disadvantage due to the enhanced radiation losses in the long wave length region, while inertial confinement will be improved by the laser effect in the X-ray region. (author)

Low values of 5-hydroxymethylcytosine (5hmC), the "sixth base," are associated with anaplasia in human brain tumors.

Science.gov (United States)

Kraus, Theo F J; Globisch, Daniel; Wagner, Mirko; Eigenbrod, Sabina; Widmann, David; Münzel, Martin; Müller, Markus; Pfaffeneder, Toni; Hackner, Benjamin; Feiden, Wolfgang; Schüller, Ulrich; Carell, Thomas; Kretzschmar, Hans A

2012-10-01

5-Methylcytosine (5 mC) in genomic DNA has important epigenetic functions in embryonic development and tumor biology. 5-Hydroxymethylcytosine (5 hmC) is generated from 5 mC by the action of the TET (Ten-Eleven-Translocation) enzymes and may be an intermediate to further oxidation and finally demethylation of 5 mC. We have used immunohistochemistry (IHC) and isotope-based liquid chromatography mass spectrometry (LC-MS) to investigate the presence and distribution of 5 hmC in human brain and brain tumors. In the normal adult brain, IHC identified 61.5% 5 hmC positive cells in the cortex and 32.4% 5 hmC in white matter (WM) areas. In tumors, positive staining of cells ranged from 1.1% in glioblastomas (GBMs) (WHO Grade IV) to 8.9% in Grade I gliomas (pilocytic astrocytomas). In the normal adult human brain, LC-MS also showed highest values in cortical areas (1.17% 5 hmC/dG [deoxyguanosine]), in the cerebral WM we measured around 0.70% 5 hmC/dG. levels were related to tumor differentiation, ranging from lowest values of 0.078% 5 hmC/dG in GBMs (WHO Grade IV) to 0.24% 5 hmC/dG in WHO Grade II diffuse astrocytomas. 5 hmC measurements were unrelated to 5 mC values. We find that the number of 5 hmC positive cells and the amount of 5 hmC/dG in the genome that has been proposed to be related to pluripotency and lineage commitment in embryonic stem cells is also associated with brain tumor differentiation and anaplasia. Copyright © 2012 UICC.

A strontium lattice clock with reduced blackbody radiation shift

Energy Technology Data Exchange (ETDEWEB)

Al-Masoudi, Ali Khalas Anfoos

2016-09-30

was measured to be 429 228 004 229 873.04 (11) Hz, with significant improvements of the statistical uncertainty due to longer measurements and using H-Maser os flywheel to cover any gaps in the operation of the Sr clock. Optical frequency ratio measurements between our clock and a single {sup 171}Yb{sup +} ion clock at PTB have been carried out, to measure a possible temporal drift of the fine structure constant α. From the measurements the most stringent limit on a potential linear drift of α over time of -0.67 x 10{sup -17} per year with an uncertainty of ±0.47 x 10{sup -17} has been derived (in preparation). Furthermore, comparisons between the Sr clocks at PTB (Braunschweig) and SYRTE (Paris) via a fiber link have been performed, and the fractional offset frequency between them has been measured to be (4.7±5.0) x 10{sup -17}. Such comparisons over large distances are an important step towards a redefinition of the SI second based on an optical transition.

95 GHz methanol masers near DR 21 and DR 21(OH)

International Nuclear Information System (INIS)

Plambeck, R.L.; Menten, K.M.

1990-01-01

The BIMA array is used to map the 95-GHz 8(0) to 7 1A(+) transition of methanol and the 98-GHz J = 2-1 transition of CS toward the DR 21(OH) and DR 21 star-forming regions. Several strong methanol masers were found. The positions of the two brightest masers were measured with an accuracy of about + or - 0.3 arcsec. Toward DR 21(OH), the positions, velocities, and line shapes of the 95 GHz masers are in excellent agreement with those of the 84-GHz 5(-1) to 4 () methanol masers previously mapped by Batrla and Menten (1988), demonstrating that maser emission in both transitions originates from the same clumps of gas. The methanol masers are offset from CS emission peaks and from other known infrared and maser sources; they may possibly be clustered along the interface between outflows, traced by shock-excited H2 emission, and dense ambient gas, traced by CS emission. 25 refs

Interstellar molecules and masers

International Nuclear Information System (INIS)

Nguyen-Q-Rieu; Guibert, J.

1978-01-01

The study of dense and dark clouds, in which hydrogen is mostly in molecular form, became possible since the discovery of interstellar molecules, emitting in the centimeter and millimeter wavelengths. The molecular lines are generally not in local thermal equilibrium (LTE). Their intensity can often be explained by invoking a population inversion mechanism. Maser emission lines due to OH, H 2 O and SiO molecules are among the most intense molecular lines. The H 2 CO molecule, detected in absorption in front of the cold cosmic background radiation of 2.7 K, illustrates the inverse phenomenon, the antimaser absorption. For a radio transition of frequency v, the inversion rate Δn (relative population difference between the upper and lower level) as well as the maser gain can be determined from the radio observations. In the case of the OH lines in the 2 PIsub(3/2), J=3/2 state, the inversion rates approximately 1 to 2% derived from the observations, are comparable with those obtained in the laboratory. The determination of the excitation mechanisms of the masers, through the statistical equilibrium and radiative transfer equations, implies the knowledge of collisional and radiative transition probabilities. A pumping model, which can satisfactorily explain the radio observations of some interstellar OH clouds, will be discussed [fr

On the spatial coincidence of hydroxyl and methanol masers

Science.gov (United States)

Hartquist, T. W.; Menten, K. M.; Lepp, S.; Dalgarno, A.

1995-01-01

We argue that purely gas-phase chemical models for the production of OH in hydroxyl masers around ultracompact H II regions such as W3(OH) cannot account for the CH_3OH in the methanol masers that are found to coincide with the hydroxyl masers in these sources. We suggest that the CH_3OH in the masers is injected into the gas phase by evaporation of the grain mantles, the grains being heated by the passage of weak shocks. Gas evaporation also injects H_2O into the gas. Photodissociation of H_2O, CH_3OH and OH occur at similar rates, and substantial abundances of CH_3OH and OH coexist.

Detection of water masers toward young stellar objects in the Large Magellanic Cloud

International Nuclear Information System (INIS)

Johanson, A. K.; Migenes, V.; Breen, S. L.

2014-01-01

We present results from a search for water maser emission toward N4A, N190, and N206, three regions of massive star formation in the Large Magellanic Cloud (LMC). Four water masers were detected; two toward N4A, and two toward N190. In the latter region, no previously known maser emission has been reported. Future studies of maser proper motion to determine the galactic dynamics of the LMC will benefit from the independent data points the new masers in N190 provide. Two of these masers are associated with previously identified massive young stellar objects (YSOs), which strongly supports the authenticity of the classification. We argue that the other two masers identify previously unknown YSOs. No masers were detected toward N206, but it does host a newly discovered 22 GHz continuum source, also associated with a massive YSO. We suggest that future surveys for water maser emission in the LMC be targeted toward the more luminous, massive YSOs.

The OH maser near the Herbig-Haro object GGD37

International Nuclear Information System (INIS)

Norris, R.P.

1980-01-01

H 2 O masers are often associated with Herbig-Haro (HH) objects, but OH masers have been found near only one HH object, GGD37. The position of this maser has been measured and it is found to be coincident with the compact H II region from which the HH object was probably ejected. (author)

THE ARECIBO METHANOL MASER GALACTIC PLANE SURVEY. IV. ACCURATE ASTROMETRY AND SOURCE MORPHOLOGIES

International Nuclear Information System (INIS)

Pandian, J. D.; Momjian, E.; Xu, Y.; Menten, K. M.; Goldsmith, P. F.

2011-01-01

We present accurate absolute astrometry of 6.7 GHz methanol masers detected in the Arecibo Methanol Maser Galactic Plane Survey using MERLIN and the Expanded Very Large Array (EVLA). We estimate the absolute astrometry to be accurate to better than 15 and 80 mas for the MERLIN and EVLA observations, respectively. We also derive the morphologies of the maser emission distributions for sources stronger than ∼1 Jy. The median spatial extent along the major axis of the regions showing maser emission is ∼775 AU. We find a majority of methanol maser morphologies to be complex with some sources previously determined to have regular morphologies in fact being embedded within larger structures. This suggests that some maser spots do not have a compact core, which leads to them being resolved in high angular resolution observations. This also casts doubt on interpretations of the origin of methanol maser emission solely based on source morphologies. We also investigate the association of methanol masers with mid-infrared emission and find very close correspondence between methanol masers and 24 μm point sources. This adds further credence to theoretical models that predict methanol masers to be pumped by warm dust emission and firmly reinforces the finding that Class II methanol masers are unambiguous tracers of embedded high-mass protostars.

SIMULTANEOUS OBSERVATIONS OF SiO AND H2O MASERS TOWARD SYMBIOTIC STARS

International Nuclear Information System (INIS)

Cho, Se-Hyung; Kim, Jaeheon

2010-01-01

We present the results of simultaneous observations of SiO v = 1, 2, J = 1-0, 29 SiO v = 0, J = 1-0, and H 2 O 6 16 -5 23 maser lines performed with the KVN Yonsei 21 m radio telescope from 2009 November to 2010 January. We searched for these masers in 47 symbiotic stars and detected maser emission from 21 stars, giving the first time detection from 19 stars. Both SiO and H 2 O masers were detected from seven stars of which six were D-type symbiotic stars and one was an S-type star, WRAY 15-1470. In the SiO maser emission, the 28 SiO v = 1 maser was detected from 10 stars, while the v = 2 maser was detected from 15 stars. In particular, the 28 SiO v = 2 maser emission without the v = 1 maser detection was detected from nine stars with a detection rate of 60%, which is much higher than that of isolated Miras/red giants. The 29 SiO v = 0 maser emission was also detected from two stars, H 2-38 and BF Cyg, together with the 28 SiO v = 2 maser. We conclude that these different observational results between isolated Miras/red giants and symbiotic stars may be related with the presence of hot companions in a symbiotic binary system.

A postprocessing method in the HMC framework for predicting gene function based on biological instrumental data

Science.gov (United States)

Feng, Shou; Fu, Ping; Zheng, Wenbin

2018-03-01

Predicting gene function based on biological instrumental data is a complicated and challenging hierarchical multi-label classification (HMC) problem. When using local approach methods to solve this problem, a preliminary results processing method is usually needed. This paper proposed a novel preliminary results processing method called the nodes interaction method. The nodes interaction method revises the preliminary results and guarantees that the predictions are consistent with the hierarchy constraint. This method exploits the label dependency and considers the hierarchical interaction between nodes when making decisions based on the Bayesian network in its first phase. In the second phase, this method further adjusts the results according to the hierarchy constraint. Implementing the nodes interaction method in the HMC framework also enhances the HMC performance for solving the gene function prediction problem based on the Gene Ontology (GO), the hierarchy of which is a directed acyclic graph that is more difficult to tackle. The experimental results validate the promising performance of the proposed method compared to state-of-the-art methods on eight benchmark yeast data sets annotated by the GO.

A SEARCH FOR 95 GHz CLASS I METHANOL MASERS IN MOLECULAR OUTFLOWS

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Gan, Cong-Gui; Chen, Xi; Shen, Zhi-Qiang [Key Laboratory for Research in Galaxies and Cosmology, Shanghai Astronomical Observatory, Chinese Academy of Sciences, 80 Nandan RD, Shanghai 200030 (China); Xu, Ye; Ju, Bing-Gang, E-mail: cggan@shao.ac.cn [Key Laboratory of Radio Astronomy, Chinese Academy of Sciences (China)

2013-01-20

We have observed a sample of 288 molecular outflow sources including 123 high-mass and 165 low-mass sources in order to search for class I methanol masers at the 95 GHz transition and to investigate the relationship between outflow characteristics and class I methanol maser emission with the Purple Mountain Observatory 13.7 m radio telescope. Our survey detected 62 sources with 95 GHz methanol masers above a 3{sigma} detection limit, which includes 47 high-mass sources and 15 low-mass sources. Therefore, the detection rate is 38% for high-mass outflow sources and 9% for low-mass outflow sources, suggesting that class I methanol masers are relatively easily excited in high-mass sources. There are 37 newly detected 95 GHz methanol masers (including 27 high-mass and 10 low-mass sources), 19 of which are newly identified (i.e., first identification) class I methanol masers (including 13 high-mass and 6 low-mass sources). A statistical analysis of the distributions of maser detections with the outflow parameters reveals that the maser detection efficiency increases with the outflow properties (e.g., mass, momentum, kinetic energy, mechanical luminosity of outflows, etc.). Systematic investigations of the relationships between the intrinsic luminosity of methanol masers and the outflow properties (including mass, momentum, kinetic energy, bolometric luminosity, and mass-loss rate of the central stellar sources) indicate a positive correlation. This further supports the theory that class I methanol masers are collisionally pumped and associated with shocks when outflows interact with the surrounding ambient medium.

Contributions for Repositioning a Regional Strategy for Healthy Municipalities, Cities and Communities (HM&C): Results of a Pan-American Survey

Science.gov (United States)

Rice, Marilyn; Vizzotti, Carlos; Frassia, Romina; Vizzotti, Pablo; Akerman, Marco

2010-01-01

This article presents the results of the 1st Regional Survey of Healthy Municipalities, Cities and Communities (HM&C) carried out in 2008 by the Pan American Health Organization (PAHO) and ISALUD University of Argentina. It discusses the responses obtained from 12 countries in the Americas Region. Key informants in Argentina, Brazil, Chile, Colombia, Costa Rica, Cuba, Mexico, Paraguay, Peru, and Uruguay were selected and encouraged to answer the survey, while informants from Canada and Honduras answered voluntarily and were included in this analysis. The discussion of the results of the Survey provides insight into the current status of HM&C in the Region and suggests key topics for repositioning the Regional strategy relative to: (1) the conceptual identity and tools for HM&C; (2) challenging areas in the implementation process (scale, legal framework, and development of capacities); (3) related strategies and participatory processes such as the ways citizen empowerment in governance is supported; (4) the need to monitor and assess the impact of the HM&C strategy on the health and quality of life of the populations involved; and (5) the need for developing a strategic research and training agenda. The analysis and discussion of these results aims to provide useful input for repositioning the strategy in the Region and contributing to the emergence of a second generation of concepts and tools capable of meeting the developing priorities and needs currently faced by the HM&C strategy. PMID:20532989

Quantum electronics maser amplifiers and oscillators

CERN Document Server

Fain, V M; Sanders, J H

2013-01-01

Quantum Electronics, Volume 2: Maser Amplifiers and Oscillators deals with the experimental and theoretical aspects of maser amplifiers and oscillators which are based on the principles of quantum electronics. It shows how the concepts and equations used in quantum electronics follow from the basic principles of theoretical physics.Comprised of three chapters, this volume begins with a discussion on the elements of the theory of quantum oscillators and amplifiers working in the microwave region, along with the practical achievements in this field. Attention is paid to two-level paramagnetic ma

Long-term Variability of H2CO Masers in Star-forming Regions

Science.gov (United States)

Andreev, N.; Araya, E. D.; Hoffman, I. M.; Hofner, P.; Kurtz, S.; Linz, H.; Olmi, L.; Lorran-Costa, I.

2017-10-01

We present results of a multi-epoch monitoring program on variability of 6 cm formaldehyde (H2CO) masers in the massive star-forming region NGC 7538 IRS 1 from 2008 to 2015, conducted with the Green Bank Telescope, the Westerbork Radio Telescope , and the Very Large Array. We found that the similar variability behaviors of the two formaldehyde maser velocity components in NGC 7538 IRS 1 (which was pointed out by Araya and collaborators in 2007) have continued. The possibility that the variability is caused by changes in the maser amplification path in regions with similar morphology and kinematics is discussed. We also observed 12.2 GHz methanol and 22.2 GHz water masers toward NGC 7538 IRS 1. The brightest maser components of CH3OH and H2O species show a decrease in flux density as a function of time. The brightest H2CO maser component also shows a decrease in flux density and has a similar LSR velocity to the brightest H2O and 12.2 GHz CH3OH masers. The line parameters of radio recombination lines and the 20.17 and 20.97 GHz CH3OH transitions in NGC 7538 IRS 1 are also reported. In addition, we observed five other 6 cm formaldehyde maser regions. We found no evidence of significant variability of the 6 cm masers in these regions with respect to previous observations, the only possible exception being the maser in G29.96-0.02. All six sources were also observed in the {{{H}}}213{CO} isotopologue transition of the 6 cm H2CO line; {{{H}}}213{CO} absorption was detected in five of the sources. Estimated column density ratios [{{{H}}}212{CO}]/[{{{H}}}213{CO}] are reported.

DISCOVERY OF NUCLEAR WATER MASER EMISSION IN CENTAURUS A

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Ott, Juergen; Meier, David S.; Walter, Fabian; Mao, Minnie Y., E-mail: jott@nrao.edu, E-mail: dmeier@nmt.edu, E-mail: walter@mpia.de, E-mail: mmao@nrao.edu [National Radio Astronomy Observatory, P.O. Box O, 1003 Lopezville Road, Socorro, NM 87801 (United States); and others

2013-07-10

We report the detection of a 22 GHz water maser line in the nearest (D {approx} 3.8 Mpc) radio galaxy Centaurus A (Cen A) using the Australia Telescope Compact Array (ATCA). The line is centered at a velocity of {approx}960 km s{sup -1}, which is redshifted by about 415 km s{sup -1} from the systemic velocity. Such an offset, as well as the width of {approx}120 km s{sup -1}, could be consistent with either a nuclear maser arising from an accretion disk of the central supermassive black hole (SMBH), or with a jet maser that is emitted from the material that is shocked near the base of the jet in Cen A. The best spatial resolution of our ATCA data constrains the origin of the maser feature within <3 pc of the SMBH. The maser exhibits an isotropic luminosity of {approx}1 L{sub Sun }, which classifies it as a kilomaser, and appears to be variable on timescales of months. A kilomaser can also be emitted by shocked gas in star-forming regions. Given the small projected distance from the core, the large offset from systemic velocity, and the smoothness of the line feature, we conclude that a jet maser line emitted by shocked gas around the base of the active galactic nucleus is the most likely explanation. For this scenario we can infer a minimum density of the radio jet of {approx}> 10 cm{sup -3}, which indicates substantial mass entrainment of surrounding gas into the propagating jet material.

Observations of Non Typical Masers at the RT-22 Radio Telescope in 2004-2013

Science.gov (United States)

Shulga, V. M.; Antyufeyev, O. V.; Zubrin, S. Y.; Myshenko, V. V.; Piddyachiy, V. I.; Korolev, A. M.; Patoka, O. M.

2017-06-01

Purpose: Some peculiarities of emission of Class I methanol masers on the 80-71A+ transition at 95 GHz in sources closely associated with protostar-forming regions and in supernova remnants are studied. Here belongs the investigation of SiO (J=2-1) maser variability in R Cassiopeiae, too. Design/methodology/approach: Search for Class I methanol masers is based on the idea of coincidence of regions of their emission with sources of OH masing transition in the bottom level of energy at frequency of 1720 MHz (2Π3/2 J=3/2 F=2-1). Findings: Two methanol masers on transition 80-71A+ (95 GHz) in the supernova remnants IC 443 and Kes 79 are detected. Variabilities of SiO maser emission on transition J=2-1 in R Cassiopeiae are shown for the first time. Conclusions: Variability of methanol and SiO masers is their general feature. On the example of three objects, the possibility of using the 1720 MHz OH maser as an indicator in the search for Class I methanol masers is shown. Especially it is important in the study of methanol maser emission in supernova remnants that has been proved to be true by detection of methanol masers on transition 80-71A+ (95 GHz) in IC 443 and Kes 79. Features of spectra variability of emission in R Cassiopeiae testify to formation and disappearance of SiO (J=2-1) masers.

FIRST INTERFEROMETRIC IMAGES OF THE 36 GHz METHANOL MASERS IN THE DR21 COMPLEX

International Nuclear Information System (INIS)

Fish, Vincent L.; Muehlbrad, Talitha C.; Pratap, Preethi; Sjouwerman, Lorant O.; Strelnitski, Vladimir; Pihlstroem, Ylva M.; Bourke, Tyler L.

2011-01-01

Class I methanol masers are believed to be produced in the shock-excited environment around star-forming regions. Many authors have argued that the appearance of various subsets of class I masers may be indicative of specific evolutionary stages of star formation or excitation conditions. Until recently, however, no major interferometer was capable of imaging the important 36 GHz transition. We report on Expanded Very Large Array observations of the 36 GHz methanol masers and Submillimeter Array observations of the 229 GHz methanol masers in DR21(OH), DR21N, and DR21W. The distribution of 36 GHz masers in the outflow of DR21(OH) is similar to that of the other class I methanol transitions, with numerous multitransition spatial overlaps. At the site of the main continuum source in DR21(OH), class I masers at 36 and 229 GHz are found in virtual overlap with class II 6.7 GHz masers. To the south of the outflow, the 36 GHz masers are scattered over a large region but usually do not appear coincident with 44 GHz masers. In DR21W, we detect an 'S-curve' signature in Stokes V that implies a large value of the magnetic field strength if interpreted as due to Zeeman splitting, suggesting either that class I masers may exist at higher densities than previously believed or that the direct Zeeman interpretation of S-curve Stokes V profiles in class I masers may be incorrect. We find a diverse variety of different maser phenomena in these sources, suggestive of differing physical conditions among them.

SOFIA/GREAT Discovery of Terahertz Water Masers

Science.gov (United States)

Neufeld, David A.; Melnick, Gary J.; Kaufman, Michael J.; Wiesemeyer, Helmut; Güsten, Rolf; Kraus, Alex; Menten, Karl M.; Ricken, Oliver; Faure, Alexandre

2017-07-01

We report the discovery of water maser emission at frequencies above 1 THz. Using the GREAT instrument on SOFIA, we have detected emission in the 1.296411 THz {8}27-{7}34 transition of water toward three oxygen-rich evolved stars: W Hya, U Her, and VY CMa. An upper limit on the 1.296 THz line flux was obtained toward R Aql. Near-simultaneous observations of the 22.23508 GHz {6}16-{5}23 water maser transition were carried out toward all four sources using the Effelsberg 100 m telescope. The measured line fluxes imply 22 GHz/1.296 THz photon luminosity ratios of 0.012, 0.12, and 0.83, respectively, for W Hya, U Her, and VY CMa, values that confirm the 22 GHz maser transition to be unsaturated in W Hya and U Her. We also detected the 1.884888 THz {8}45-{7}52 transition toward W Hya and VY CMa, and the 1.278266 THz {7}43-{6}52 transition toward VY CMa. Like the 22 GHz maser transition, all three of the THz emission lines detected here originate from the ortho-H2O spin isomer. Based upon a model for the circumstellar envelope of W Hya, we estimate that stimulated emission is responsible for ˜85% of the observed 1.296 THz line emission, and thus that this transition may be properly described as a terahertz-frequency maser. In the case of the 1.885 THz transition, by contrast, our W Hya model indicates that the observed emission is dominated by spontaneous radiative decay, even though a population inversion exists. GREAT is a development by the MPI für Radioastronomie and the KOSMA/Universität zu Köln, in cooperation with the MPI für Sonnensystemforschung and the DLR Institut für Planetenforschung.

Cosmic masers: protostars, protoplanets, or signals from outer space civilizations

Energy Technology Data Exchange (ETDEWEB)

Strelnitskii, V

1976-02-01

A summary of the existing knowledge of cosmic masers including the history of their discovery is presented. The mechanism of maser excitation and the probable course of this process in cosmic space is described.

Array-based assay detects genome-wide 5-mC and 5-hmC in the brains of humans, non-human primates, and mice.

Science.gov (United States)

Chopra, Pankaj; Papale, Ligia A; White, Andrew T J; Hatch, Andrea; Brown, Ryan M; Garthwaite, Mark A; Roseboom, Patrick H; Golos, Thaddeus G; Warren, Stephen T; Alisch, Reid S

2014-02-13

Methylation on the fifth position of cytosine (5-mC) is an essential epigenetic mark that is linked to both normal neurodevelopment and neurological diseases. The recent identification of another modified form of cytosine, 5-hydroxymethylcytosine (5-hmC), in both stem cells and post-mitotic neurons, raises new questions as to the role of this base in mediating epigenetic effects. Genomic studies of these marks using model systems are limited, particularly with array-based tools, because the standard method of detecting DNA methylation cannot distinguish between 5-mC and 5-hmC and most methods have been developed to only survey the human genome. We show that non-human data generated using the optimization of a widely used human DNA methylation array, designed only to detect 5-mC, reproducibly distinguishes tissue types within and between chimpanzee, rhesus, and mouse, with correlations near the human DNA level (R(2) > 0.99). Genome-wide methylation analysis, using this approach, reveals 6,102 differentially methylated loci between rhesus placental and fetal tissues with pathways analysis significantly overrepresented for developmental processes. Restricting the analysis to oncogenes and tumor suppressor genes finds 76 differentially methylated loci, suggesting that rhesus placental tissue carries a cancer epigenetic signature. Similarly, adapting the assay to detect 5-hmC finds highly reproducible 5-hmC levels within human, rhesus, and mouse brain tissue that is species-specific with a hierarchical abundance among the three species (human > rhesus > mouse). Annotation of 5-hmC with respect to gene structure reveals a significant prevalence in the 3'UTR and an association with chromatin-related ontological terms, suggesting an epigenetic feedback loop mechanism for 5-hmC. Together, these data show that this array-based methylation assay is generalizable to all mammals for the detection of both 5-mC and 5-hmC, greatly improving the utility of mammalian model systems

Water Masers and Accretion Disks in Galactic Nuclei

Science.gov (United States)

Greenhill, L. J.

2005-12-01

There are over 50 sources of H2O maser emission in type-2 active galactic nuclei, a large fraction discovered in the last two years. Interferometer maps of water masers are presently the only means by which structures ⪉ 1 pc from massive black holes can be mapped directly, which is particularly important for type-2 systems because edge-on orientation and obscuration complicate study by other means. Investigations of several sources have demonstrated convincingly that the maser emission traces warped accretion disks 0.1 to 1 pc from central engines of order 106-108 M⊙. The same may be true for almost half the known (but unmapped) sources, based on spectral characteristics consistent with emission from edge-on accretion disks. Mapping these sources is a high priority. Study of most recently discovered masers requires long baseline arrays that include 100-m class apertures and would benefit from aggregate bit rates on the order of 1 gigabit per second. The Square Kilometer Array should provide an order of magnitude boost in mapping sensitivity, but outrigger antennas will be needed to achieve necesssary angular resolutions, as may be space-borne antennas.

Circumstellar H2O maser emission associated with four late-type stars

International Nuclear Information System (INIS)

Johnston, K.J.; Spencer, J.H.; Bowers, P.F.

1985-01-01

The positions and structure of H2O maser associated with four long-period stars were measured using the VLA, and the results are discussed. The four stars observed were: RX Boo; R Aq1; RR Aq1; and NML Cyg. The spatial resolution of the VLA measurements was 0.07 arcsec. The H2O maser emission features appear as unresolved knots distributed over an area of no more than 0.4 arcsec. The velocity and spatial characteristics of the maser regions in R Aq1 and RR Aq1 were found to change considerably over time. The estimated sizes of the H2O maser emission were 8 x 10 to the 14th for RX Boo, R Aq1, and RR Aq1. The supergiant star NML Cyg had the largest maser region (10 to the 16th) which is comparable to that of VY CMa. The positional accuracy for individual maser features ranged between 0.03 and 0.09 arcsec. However, the precise location of the maser emission relative to the stellar photocenter did not fit the velocity and spatial distributions of the emission and therefore may be inappropriate as a standard for comparisons of stellar reference frames. 20 references

The relationship between Class I and Class II methanol masers at high angular resolution

Science.gov (United States)

McCarthy, T. P.; Ellingsen, S. P.; Voronkov, M. A.; Cimò, G.

2018-06-01

We have used the Australia Telescope Compact Array (ATCA) to make the first high-resolution observations of a large sample of class I methanol masers in the 95-GHz (80-71A+) transition. The target sources consist of a statistically complete sample of 6.7-GHz class II methanol masers with an associated 95-GHz class I methanol maser, enabling a detailed study of the relationship between the two methanol maser classes at arcsecond angular resolution. These sources have been previously observed at high resolution in the 36- and 44-GHz transitions, allowing comparison between all three class I maser transitions. In total, 172 95-GHz maser components were detected across the 32 target sources. We find that at high resolution, when considering matched maser components, a 3:1 flux density ratio is observed between the 95- and 44-GHz components, consistent with a number of previous lower angular resolution studies. The 95-GHz maser components appear to be preferentially located closer to the driving sources and this may indicate that this transition is more strongly inverted nearby to background continuum sources. We do not observe an elevated association rate between 95-GHz maser emission and more evolved sources, as indicated by the presence of 12.2-GHz class II masers. We find that in the majority of cases where both class I and class II methanol emission is observed, some component of the class I emission is associated with a likely outflow candidate.

Nanosecond time-resolved characterization of a pentacene-based room-temperature MASER

Science.gov (United States)

Salvadori, Enrico; Breeze, Jonathan D.; Tan, Ke-Jie; Sathian, Juna; Richards, Benjamin; Fung, Mei Wai; Wolfowicz, Gary; Oxborrow, Mark; Alford, Neil McN.; Kay, Christopher W. M.

2017-01-01

The performance of a room temperature, zero-field MASER operating at 1.45 GHz has been examined. Nanosecond laser pulses, which are essentially instantaneous on the timescale of the spin dynamics, allow the visible-to-microwave conversion efficiency and temporal response of the MASER to be measured as a function of excitation energy. It is observed that the timing and amplitude of the MASER output pulse are correlated with the laser excitation energy: at higher laser energy, the microwave pulses have larger amplitude and appear after shorter delay than those recorded at lower laser energy. Seeding experiments demonstrate that the output variation may be stabilized by an external source and establish the minimum seeding power required. The dynamics of the MASER emission may be modeled by a pair of first order, non-linear differential equations, derived from the Lotka-Volterra model (Predator-Prey), where by the microwave mode of the resonator is the predator and the spin polarization in the triplet state of pentacene is the prey. Simulations allowed the Einstein coefficient of stimulated emission, the spin-lattice relaxation and the number of triplets contributing to the MASER emission to be estimated. These are essential parameters for the rational improvement of a MASER based on a spin-polarized triplet molecule. PMID:28169331

Epigenomic Co-localization and Co-evolution Reveal a Key Role for 5hmC as a Communication Hub in the Chromatin Network of ESCs

Directory of Open Access Journals (Sweden)

David Juan

2016-02-01

Full Text Available Summary: Epigenetic communication through histone and cytosine modifications is essential for gene regulation and cell identity. Here, we propose a framework that is based on a chromatin communication model to get insight on the function of epigenetic modifications in ESCs. The epigenetic communication network was inferred from genome-wide location data plus extensive manual annotation. Notably, we found that 5-hydroxymethylcytosine (5hmC is the most-influential hub of this network, connecting DNA demethylation to nucleosome remodeling complexes and to key transcription factors of pluripotency. Moreover, an evolutionary analysis revealed a central role of 5hmC in the co-evolution of chromatin-related proteins. Further analysis of regions where 5hmC co-localizes with specific interactors shows that each interaction points to chromatin remodeling, stemness, differentiation, or metabolism. Our results highlight the importance of cytosine modifications in the epigenetic communication of ESCs. : 5-hydroxymethylcytosine (5hmC plays a key role in the epigenomic communication network of embryonic stem cells. Juan et al. build a communication network based in co-localization of epigenomic data and literature. The analysis of the network and its components reveals that proteins reading and editing 5hmC co-evolve and serve as links between diverse molecular processes.

MASER: Measuring, Analysing, Simulating low frequency Radio Emissions.

Science.gov (United States)

Cecconi, B.; Le Sidaner, P.; Savalle, R.; Bonnin, X.; Zarka, P. M.; Louis, C.; Coffre, A.; Lamy, L.; Denis, L.; Griessmeier, J. M.; Faden, J.; Piker, C.; André, N.; Genot, V. N.; Erard, S.; King, T. A.; Mafi, J. N.; Sharlow, M.; Sky, J.; Demleitner, M.

2017-12-01

The MASER (Measuring, Analysing and Simulating Radio Emissions) project provides a comprehensive infrastructure dedicated to low frequency radio emissions (typically Radioastronomie de Nançay and the CDPP deep archive. These datasets include Cassini/RPWS, STEREO/Waves, WIND/Waves, Ulysses/URAP, ISEE3/SBH, Voyager/PRA, Nançay Decameter Array (Routine, NewRoutine, JunoN), RadioJove archive, swedish Viking mission, Interball/POLRAD... MASER also includes a Python software library for reading raw data.

SiO MASERS AROUND WX PSC MAPPED WITH THE KVN AND VERA ARRAY (KaVA)

Energy Technology Data Exchange (ETDEWEB)

Yun, Youngjoo; Cho, Se-Hyung; Kim, Jaeheon; Choi, Yoon Kyung; Kim, Dong-Jin; Yoon, Dong-Hwan; Byun, Do-Young; Chung, Hyunsoo; Chung, Moon-Hee; Han, Myoung-Hee [Korea Astronomy and Space Science Institute, 776 Daedeok-daero, Yuseong, Daejeon 305-348 (Korea, Republic of); Imai, Hiroshi; Oyadomari, Miyako [Graduate School of Science and Engineering, Kagoshima University, 1-21-35 Korimoto, Kagoshima 890-0065 (Japan); Asaki, Yoshiharu [National Astronomical Observatory of Japan (NAOJ) Chile Observatory/Joint ALMA Observatory (JAO), Alonso de Cordova 3107, Vitacura 763 0355, Santiago (Chile); Chibueze, James O. [Department of Physics and Astronomy, Faculty of Physical Sciences, University of Nigeria, Carver Building, 1 University Road, Nsukka (Nigeria); Dodson, Richard; Rioja, María J. [International Centre for Radio Astronomy Research, M468, The University of Western Australia, 35 Stirling Hwy, Crawley, Western Australia 6009 (Australia); Kusuno, Kozue [Department of Space and Astronautical Science, School of Physical Sciences, The Graduate University for Advanced Studies (SOKENDAI), 3-1-1 Yoshinodai, Chuou-Ku, Sagamihara, Kanagawa 252-5210 (Japan); Matsumoto, Naoko; Hagiwara, Yoshiaki [Mizusawa VLBI Observatory, National Astronomical Observatory of Japan, 2-21-1 Osawa, Mitaka, Tokyo 181-8588 (Japan); Min, Cheulhong, E-mail: yjyun@kasi.re.kr, E-mail: cho@kasi.re.kr [Department of Astronomical Sciences, The Graduate University for Advanced Studies (SOKENDAI), 2-21-1 Osawa, Mitaka, Tokyo 181-8588 (Japan); and others

2016-05-01

We present the first images of the v = 1 and v = 2 J = 1 → 0 SiO maser lines taken with KaVA, i.e., the combined array of the Korean Very Long Baseline Interferometry (VLBI) Network and the VLBI Exploration of Radio Astrometry (VERA), toward the OH/IR star WX Psc. The combination of long and short antenna baselines enabled us to detect a large number of maser spots, which exhibit a typical ring-like structure in both the v = 1 and v = 2 J = 1 → 0 SiO masers as those that have been found in previous VLBI observational results of WX Psc. The relative alignment of the v = 1 and v = 2 SiO maser spots are precisely derived from astrometric analysis, due to the absolute coordinates of the reference maser spot that were well determined in an independent astrometric observation with VERA. The superposition of the v = 1 and v = 2 maser spot maps shows a good spatial correlation between the v = 1 and v = 2 SiO maser features. Nevertheless, it is also shown that the v = 2 SiO maser spot is distributed in an inner region compared to the v = 1 SiO maser by about 0.5 mas on average. These results provide good support for the recent theoretical studies of the SiO maser pumping, in which both the collisional and the radiative pumping predict the strong spatial correlation and the small spatial discrepancy between the v = 1 and v = 2 SiO maser.

MERLIN observations of water maser proper motions in VY Canis Majoris

Science.gov (United States)

Richards, A. M. S.; Yates, J. A.; Cohen, R. J.

1998-09-01

MERLIN observations of the 22-GHz water masers in the circumstellar envelope of the supergiant VY CMa show an ellipsoidal distribution with a maximum extent of 700 mas east-west and 400 mas north-south. Comparison with observations made nine years earlier shows that the majority of maser features have survived and show proper motions throughout the region. The mean change in position is 28 mas and the proper motions are generally directed away from the assumed stellar position, and tend to be larger for features at greater projected distances. If the H_2O maser region is modelled as a partially filled thick spherical shell, and VY CMa is at a distance of 1.5 kpc, then the proper motion velocities in the direction of expansion are between 8kms^-1 at a distance of 75 mas from the assumed stellar position and 32kms^-1 at 360 mas. These velocities are consistent with the H_2O maser spectral line velocities which correspond to a maximum expansion velocity of 36kms^-1 at 400 mas from the assumed stellar position. These observations are consistent with radiation pressure on dust providing the force to accelerate the stellar wind as it passes through the H_2O maser shell. The H_2O maser region is elongated in the same direction as the dusty nebula around VY CMa. The water masers illuminate the small-scale dynamics and clumpiness which show the role of dust in driving the outflow. The overall ellipsoidal shape may be due to properties of the dust, such as its behaviour in the stellar magnetic field, or to interaction between the wind and circumstellar material. Maser monitoring also shows the difference between changes on the time-scale of stellar variability (a few years) and possible stages in the evolution of VY CMa to its likely fate as a supernova.

Techniques for Accurate Parallax Measurements for 6.7 GHz Methanol Masers

Energy Technology Data Exchange (ETDEWEB)

Reid, M. J. [Harvard-Smithsonian Center for Astrophysics, 60 Garden Street, Cambridge, MA 02138 (United States); Brunthaler, A.; Menten, K. M.; Sanna, A. [Max-Planck-Institut für Radioastronomy, Auf dem Hügel 69, D-53121-Bonn (Germany); Xu, Y.; Sakai, N. [Mizusawa VLBI Observatory, National Astronomical Observatory of Japan, 2-21-1 Osawa, Mitaka, Tokyo 181-8588 (Japan); Li, J. J.; Wu, Y.; Hu, B. [Purple Mountain Observatory, Chinese Academy of Sciences, Nanjing 210008 (China); Zheng, X. W. [Department of Astronomy, Nanjing University, Nanjing 210093 (China); Zhang, B. [Shanghai Astrophysical Observatory, 80 Nandan Road, Shanghai 200030 (China); Immer, K. [European Southern Observatory, Karl-Schwarzschild-Strasse 2, D-85748, Garching bei München (Germany); Rygl, K. [Italian ALMA Regional Centre, INAF—Istituto di Radioastronomia, Via P. Gobetti 101, I-40129 Bologna (Italy); Moscadelli, L. [INAF-Osservatorio Astrofisico di Arcetri, Largo E. Fermi 5, I-50125, Firenze (Italy); Bartkiewicz, A. [Centre for Astronomy, Faculty of Physics, Astronomy and Informatics, Nicolaus Copernicus University, Grudziadzka 5, 87-100 Torun (Poland); Choi, Y. K. [Korea Astronomy and Space Science Institute 776, Daedeokdae-ro, Yuseong-gu, Daejeon, 34055 (Korea, Republic of)

2017-08-01

The BeSSeL Survey is mapping the spiral structure of the Milky Way by measuring trigonometric parallaxes of hundreds of maser sources associated with high-mass star formation. While parallax techniques for water masers at high frequency (22 GHz) have been well documented, recent observations of methanol masers at lower frequency (6.7 GHz) have revealed astrometric issues associated with signal propagation through the ionosphere that could significantly limit parallax accuracy. These problems displayed as a “parallax gradient” on the sky when measured against different background quasars. We present an analysis method in which we generate position data relative to an “artificial quasar” at the target maser position at each epoch. Fitting parallax to these data can significantly mitigate the problems and improve parallax accuracy.

Optical-coupling nuclear spin maser under highly stabilized low static field

Energy Technology Data Exchange (ETDEWEB)

Yoshimi, A., E-mail: yoshimi@ribf.riken.jp [RIKEN Nishina Center (Japan); Inoue, T.; Uchida, M.; Hatakeyama, N.; Asahi, K. [Tokyo Institute of Technology, Department of Physics (Japan)

2008-01-15

A nuclear spin maser of a new type, that employs a feedback scheme based on optical nuclear spin detection, has been fabricated. The spin maser is operated at a low static field of 30 mG by using the optical detection method. The frequency stability and precision of the spin maser have been improved by a highly stabilized current source for the static magnetic field. An experimental setup to search for an electric dipole moment (EDM) in {sup 129}Xe atom is being developed.

New Tests for Variations of the Fine Structure Constant

Science.gov (United States)

Prestage, John D.

1995-01-01

We describe a new test for possible variations of the fine structure constant, by comparisons of rates between clocks based on hyperfine transitions in alkali atomos with different atomic number Z. H- maser, Cs and Hg+ clocks have a different dependence on ia relativistic contributions of order (Z. Recent H-maser vs Hg+ clock comparison data improves laboratory limits on a time variation by 100-fold to giveFuture laser cooled clocks (Be+, Rb, Cs, Hg+, etc.), when compared, will yield the most senstive of all tests for.

Searches for H2O masers toward narrow-line Seyfert 1 galaxies

Science.gov (United States)

Yoshiaki, Hagiwara; Doi, Akihiro; Hachisuka, Kazuya; Horiuchi, Shinji

2018-05-01

We present searches for 22 GHz H2O masers toward 36 narrow-line Seyfert 1 galaxies (NLS1s), selected from known NLS1s with vsys ≲ 41000 km s-1. Out of the 36 NLS1s in our sample, 11 have been first surveyed in our observations, while the observations of other NLS1s were previously reported in literature. In our survey, no new water maser source from NLS1s was detected at the 3σ rms level of 8.4 mJy to 144 mJy, which depends on different observing conditions or inhomogeneous sensitivities of each observation using three different telescopes. It is likely that the non-detection of new masers in our NLS1 sample is primarily due to insufficient sensitivities of our observations. Including the five known NLS1 masers, the total detection rate of the H2O maser in NLS1s is not remarkably different from that of type 2 Seyfert galaxies or LINERs. However, more extensive and systematic searches of NLS1 would be required for a statistical discussion of the detection rate of the NLS1 maser, compared with that of type 2 Seyferts or LINERs.

LINEAR POLARIZATION OF CLASS I METHANOL MASERS IN MASSIVE STAR-FORMING REGIONS

International Nuclear Information System (INIS)

Kang, Ji-hyun; Byun, Do-Young; Kim, Kee-Tae; Kim, Jongsoo; Lyo, A-Ran; Vlemmings, W. H. T.

2016-01-01

Class I methanol masers are found to be good tracers of the interaction between outflows from massive young stellar objects with their surrounding media. Although polarization observations of Class II methanol masers have been able to provide information about magnetic fields close to the central (proto)stars, polarization observations of Class I methanol masers are rare, especially at 44 and 95 GHz. We present the results of linear polarization observations of 39 Class I methanol maser sources at 44 and 95 GHz. These two lines are observed simultaneously with one of the 21 m Korean VLBI Network telescopes in single-dish mode. Approximately 60% of the observed sources have fractional polarizations of a few percent in at least one transition. This is the first reported detection of linear polarization of the 44 GHz methanol maser. The two maser transitions show similar polarization properties, indicating that they trace similar magnetic environments, although the fraction of the linear polarization is slightly higher at 95 GHz. We discuss the association between the directions of polarization angles and outflows. We also discuss some targets having different polarization properties at both lines, including DR21(OH) and G82.58+0.20, which show the 90° polarization angle flip at 44 GHz.

DISTANCES TO DARK CLOUDS: COMPARING EXTINCTION DISTANCES TO MASER PARALLAX DISTANCES

International Nuclear Information System (INIS)

Foster, Jonathan B.; Jackson, James M.; Stead, Joseph J.; Hoare, Melvin G.; Benjamin, Robert A.

2012-01-01

We test two different methods of using near-infrared extinction to estimate distances to dark clouds in the first quadrant of the Galaxy using large near-infrared (Two Micron All Sky Survey and UKIRT Infrared Deep Sky Survey) surveys. Very long baseline interferometry parallax measurements of masers around massive young stars provide the most direct and bias-free measurement of the distance to these dark clouds. We compare the extinction distance estimates to these maser parallax distances. We also compare these distances to kinematic distances, including recent re-calibrations of the Galactic rotation curve. The extinction distance methods agree with the maser parallax distances (within the errors) between 66% and 100% of the time (depending on method and input survey) and between 85% and 100% of the time outside of the crowded Galactic center. Although the sample size is small, extinction distance methods reproduce maser parallax distances better than kinematic distances; furthermore, extinction distance methods do not suffer from the kinematic distance ambiguity. This validation gives us confidence that these extinction methods may be extended to additional dark clouds where maser parallaxes are not available.

Saturation and beaming in astrophysical masers. II. The fully saturated limit

International Nuclear Information System (INIS)

Alcock, C.; Ross, R.R.; College of the Holy Cross, Worcester, MA)

1985-01-01

Radiative transfer in fully saturated maser clouds has been investigated using the four-stream model equations of Alcock and Ross (1985). It is shown that a modest elongation of the maser cloud produces a substantial asymmetry in the maser output. The ratio of output fluxes in different directions is a strong function of the ratio of the corresponding chord lengths across the cloud. Arguments are presented that the asymmetries reported here for the four-stream models closely mimic the asymmetries that should be expected in a real master cloud. 10 references

FORMALDEHYDE MASERS: EXCLUSIVE TRACERS OF HIGH-MASS STAR FORMATION

Energy Technology Data Exchange (ETDEWEB)

Araya, E. D.; Brown, J. E. [Western Illinois University, Physics Department, 1 University Circle, Macomb, IL 61455 (United States); Olmi, L. [INAF, Osservatorio Astrofisico di Arcetri, Largo E. Fermi 5, I-50125 Firenze (Italy); Ortiz, J. Morales [University of Puerto Rico, Río Piedras Campus, Physical Sciences Department, P.O. Box 23323, San Juan, PR 00931 (United States); Hofner, P.; Creech-Eakman, M. J. [New Mexico Institute of Mining and Technology, Physics Department, 801 Leroy Place, Socorro, NM 87801 (United States); Kurtz, S. [Instituto de Radioastronomía y Astrofísica, Universidad Nacional Autónoma de México, Apdo. Postal 3-72, 58089 Morelia, Michoacán (Mexico); Linz, H. [Max-Planck-Institut für Astronomie, Königstuhl 17, D-69117 Heidelberg (Germany)

2015-11-15

The detection of four formaldehyde (H{sub 2}CO) maser regions toward young high-mass stellar objects in the last decade, in addition to the three previously known regions, calls for an investigation of whether H{sub 2}CO masers are an exclusive tracer of young high-mass stellar objects. We report the first survey specifically focused on the search for 6 cm H{sub 2}CO masers toward non high-mass star-forming regions (non HMSFRs). The observations were conducted with the 305 m Arecibo Telescope toward 25 low-mass star-forming regions, 15 planetary nebulae and post-AGB stars, and 31 late-type stars. We detected no H{sub 2}CO emission in our sample of non HMSFRs. To check for the association between high-mass star formation and H{sub 2}CO masers, we also conducted a survey toward 22 high-mass star-forming regions from a Hi-GAL (Herschel infrared Galactic Plane Survey) sample known to harbor 6.7 GHz CH{sub 3}OH masers. We detected a new 6 cm H{sub 2}CO emission line in G32.74−0.07. This work provides further evidence that supports an exclusive association between H{sub 2}CO masers and young regions of high-mass star formation. Furthermore, we detected H{sub 2}CO absorption toward all Hi-GAL sources, and toward 24 low-mass star-forming regions. We also conducted a simultaneous survey for OH (4660, 4750, 4765 MHz), H110α (4874 MHz), HCOOH (4916 MHz), CH{sub 3}OH (5005 MHz), and CH{sub 2}NH (5289 MHz) toward 68 of the sources in our sample of non HMSFRs. With the exception of the detection of a 4765 MHz OH line toward a pre-planetary nebula (IRAS 04395+3601), we detected no other spectral line to an upper limit of 15 mJy for most sources.

Study of plasma-maser instability in an inhomogeneous plasma

International Nuclear Information System (INIS)

Singh, Mahinder

2006-01-01

The plasma-maser, an interesting nonlinear process in plasmas, is an effective means of energy up-conversion in frequency from low-frequency turbulence to a high-frequency wave. A theoretical study is made of the amplification mechanism of an electrostatic Bernstein mode wave in presence of Langmuir wave turbulence in a magnetized inhomogeneous plasma on the basis of a plasma-maser interaction. It is shown that a test high-frequency electrostatic Bernstein mode wave is unstable in the presence of low-frequency Langmuir wave turbulence. The growth rate of a test high-frequency Bernstein mode wave is calculated with the involvement of a spatial density gradient parameter. A comparative study on the role of density gradient in the generation of the Bernstein mode on the basis of the plasma-maser effect is presented

Effect of gamma-ray irradiated natural herbal extracts on NF-kB activation in HMC-1 cells

International Nuclear Information System (INIS)

Kim, Yong Soo; Lim, Youn Mook; Gwon, Hui Jeong; Choi, Bo Ram; Nho, Young Chang

2009-01-01

Recently, studies have documented various health benefits of some natural herbal extracts (NHE) such as Houttuynia cordata (H), Centella asiatica (C), Plantago asiatica (P), Morus alba L. (M), and Ulmus davidiana (U). The aim of the present study was to demonstrate the radiation effect on NF-kB activation of the NHE in the human mast cell line (HMC-1). The HMC-1 cells were stimulated with phorbol 12-myristate 13-acetate (PMA) plus A23187. Both non-and irradiated NHE also significantly inhibited the PMA plus A23187-induced nuclear factor NF-kB activation and also suppressed the expression of activation of NF-kB. These results indicated that the NHE exerted a regulatory effect on inflammatory reactions mediated by mast cells

Effect of gamma-ray irradiated natural herbal extracts on NF-kB activation in HMC-1 cells

Energy Technology Data Exchange (ETDEWEB)

Kim, Yong Soo; Lim, Youn Mook; Gwon, Hui Jeong; Choi, Bo Ram; Nho, Young Chang [Korea Atomic Energy Research Institute, Jeongeup (Korea, Republic of)

2009-12-15

Recently, studies have documented various health benefits of some natural herbal extracts (NHE) such as Houttuynia cordata (H), Centella asiatica (C), Plantago asiatica (P), Morus alba L. (M), and Ulmus davidiana (U). The aim of the present study was to demonstrate the radiation effect on NF-kB activation of the NHE in the human mast cell line (HMC-1). The HMC-1 cells were stimulated with phorbol 12-myristate 13-acetate (PMA) plus A23187. Both non-and irradiated NHE also significantly inhibited the PMA plus A23187-induced nuclear factor NF-kB activation and also suppressed the expression of activation of NF-kB. These results indicated that the NHE exerted a regulatory effect on inflammatory reactions mediated by mast cells.

Low-cost electron-gun pulser for table-top maser experiments

Science.gov (United States)

Grinberg, V.; Jerby, E.; Shahadi, A.

1995-04-01

A simple 10 kV electron-gun pulser for small-scale maser experiments is presented. This low-cost pulser has operated successfully in various table-top cyclotron-resonance maser (CRM) and free-electron maser (FEM) experiments. It consists of a low-voltage capacitor bank, an SCR control circuit and a transformer bank (car ignition coils) connected directly to the e-gun. The pulser produces a current of 3 A at 10 kV voltage in a Gaussian like shape of 1 ms pulse width. The voltage sweep during the pulse provides a useful tool to locate resonances of CRM and FEM interactions. Analytical expressions for the pulser design and experimental measurements are presented.

A Masing Event in NGC 6334I: Contemporaneous Flaring of Hydroxyl, Methanol and Water Masers

Science.gov (United States)

MacLeod, G. C.; Smits, D. P.; Goedhart, S.; Hunter, T. R.; Brogan, C. L.; Chibueze, J. O.; van den Heever, S. P.; Thesner, C. J.; Banda, P. J.; Paulsen, J. D.

2018-04-01

As a product of the maser monitoring program with the 26 m telescope of the Hartebeesthoek Radio Astronomy Observatory (HartRAO), we present an unprecedented, contemporaneous flaring event of 10 maser transitions in hydroxyl, methanol, and water that began in 2015 January in the massive star-forming region NGC 6334I in the velocity range -10 to -2 km s-1. The 6.7 GHz methanol and 22.2 GHz water masers began flaring within 22 days of each other, while the 12.2 GHz methanol and 1665 MHz hydroxyl masers flared 80 and 113 days later respectively. The 1665 MHz, 6.7 GHz, and 22.2 GHz masers have all remained in their flared state for nearly 3 years. The brightest flaring components increased by factors of 66, 21, 26, and 20 in the 12.2 and 6.7 GHz methanol, 1665 MHz hydroxyl and 22.2 GHz water maser transitions respectively; some weaker components increased by up to a factor of 145. We also report new maser emission in the 1720, 6031, and 6035 MHz OH lines and the 23.1 GHz methanol line, along with the detection of only the fifth 4660 MHz OH maser. We note the correlation of this event with the extraordinary (sub)millimeter continuum outburst from the massive protostellar system NGC 6334I-MM1 and discuss the implications of the observed time lags between different maser velocity components on the nature of the outburst. Finally, we identify two earlier epoch maser flaring events likely associated with this object, which suggest a recurring accretive phenomenon that generates powerful radiative outbursts.

Special Hydron Maser Workshop held on Wednesday, December 5, 1990

Science.gov (United States)

1990-12-01

described in the paper by N.B. Koshelyacvsky of VNIIFTRI given on Dece~llber I , the drift in wall shift of their masers was about 1 x 10-’\\cr day. No data...liperatrires tend to givc rise to grcatcr frequency drifts. Thercfoce, they arc pla~lning to put a CIII-75 maser in a refrigerator at VNIIFTRI to

Very long baseline interferometric observations of the hydroxyl masers in VY Canis Majoris

Science.gov (United States)

Reid, M. J.; Muhleman, D. O.

1978-01-01

Results are presented for spectral-line VLBI observations of the OH emission from VY CMa. The main-line (1665 and 1667 MHz) emission was mapped with an angular resolution of 0.02 arcsec by analyzing interferometer phase data. The main-line emission comes from many maser components of apparent size less than 0.03 arcsec which are separated by up to 0.5 arcsec. New maser features near the center of the OH spectra were detected and found to lie within the region encompassed by the low-velocity OH emission. The 1612-MHz emission was mapped by Fourier inversion of the VLBI data from two baselines. All spatially isolated maser components appeared smaller than 0.15 arcsec; however, the maser emission is very complex at most velocities. Maser components within a velocity range of 1.3 km/s are often separated by more than 1 arcsec, while components more than 10 km/s apart in each emission complex are often coincident to 0.2 arcsec.

Phase locking of a semiconductor double-quantum-dot single-atom maser

Science.gov (United States)

Liu, Y.-Y.; Hartke, T. R.; Stehlik, J.; Petta, J. R.

2017-11-01

We experimentally study the phase stabilization of a semiconductor double-quantum-dot (DQD) single-atom maser by injection locking. A voltage-biased DQD serves as an electrically tunable microwave frequency gain medium. The statistics of the maser output field demonstrate that the maser can be phase locked to an external cavity drive, with a resulting phase noise L =-99 dBc/Hz at a frequency offset of 1.3 MHz. The injection locking range, and the phase of the maser output relative to the injection locking input tone are in good agreement with Adler's theory. Furthermore, the electrically tunable DQD energy level structure allows us to rapidly switch the gain medium on and off, resulting in an emission spectrum that resembles a frequency comb. The free running frequency comb linewidth is ≈8 kHz and can be improved to less than 1 Hz by operating the comb in the injection locked regime.

A size upper limit and position for the HCN maser in CIT 6

International Nuclear Information System (INIS)

Carlstrom, J.E.; Welch, W.J.; Goldsmith, P.F.; Lis, D.C.

1990-01-01

A size upper limit and position for the HCN maser in CIT 6 were determined from interferometric observations with the Hat Creek millimeter array. The maser is located at alpha(1950) = 10 h 13 m 10.942 + or - 0.012 s and delta(1950) = + 30 deg 49 arcmin 16.75 arcsec + or - 0.15, coincident with the optical image taken from the Palomar plates, within the 3 arcsec uncertainty of the latter. The size of the maser emission region is less than 0.45 arcsec, approximately 180 AU at the distance estimated for CIT 6. The small size and strong emission (40 Jy) set a lower limit to the brightness temperature of 44,000 K, further strengthening the maser interpretation. 14 refs

THE ARECIBO METHANOL MASER GALACTIC PLANE SURVEY. III. DISTANCES AND LUMINOSITIES

International Nuclear Information System (INIS)

Pandian, J. D.; Menten, K. M.; Goldsmith, P. F.

2009-01-01

We derive kinematic distances to the 86 6.7 GHz methanol masers discovered in the Arecibo Methanol Maser Galactic Plane Survey. The systemic velocities of the sources were derived from 13 CO (J = 2-1), CS (J = 5-4), and NH 3 observations made with the ARO Submillimeter Telescope, the APEX telescope, and the Effelsberg 100 m telescope, respectively. Kinematic distance ambiguities were resolved using H I self-absorption with H I data from the VLA Galactic Plane Survey. We observe roughly three times as many sources at the far distance compared to the near distance. The vertical distribution of the sources has a scale height of ∼ 30 pc, and is much lower than that of the Galactic thin disk. We use the distances derived in this work to determine the luminosity function of 6.7 GHz maser emission. The luminosity function has a peak at approximately 10 -6 L sun . Assuming that this luminosity function applies, the methanol maser population in the Large Magellanic Cloud and M33 is at least 4 and 14 times smaller, respectively, than in our Galaxy.

Widespread HCN maser emission in carbon-rich evolved stars

Science.gov (United States)

Menten, K. M.; Wyrowski, F.; Keller, D.; Kamiński, T.

2018-05-01

Context. HCN is a major constituent of the circumstellar envelopes of carbon-rich evolved stars, and rotational lines from within its vibrationally excited states probe parts of these regions closest to the stellar surface. A number of such lines are known to show maser action. Historically, in one of them, the 177 GHz J = 2 → 1 line in the l-doubled bending mode has been found to show relatively strong maser action, with results only published for a single object, the archetypical high-mass loss asymptotic giant branch (AGB) star IRC+10216. Aims: To examine how common 177 GHz HCN maser emission is, we conducted an exploratory survey for this line toward a select sample of carbon-rich asymptotic giant branch stars that are observable from the southern hemisphere. Methods: We used the Atacama Pathfinder Experiment 12 meter submillimeter Telescope (APEX) equipped with a new receiver to simultaneously observe three J = 2 → 1 HCN rotational transitions, the (0, 11c, 0) and (0, 11d, 0) l-doublet components, and the line from the (0,0,0) ground state. Results: The (0, 11c, 0) maser line is detected toward 11 of 13 observed sources, which all show emission in the (0,0,0) transition. In most of the sources, the peak intensity of the (0, 11c, 0) line rivals that of the (0,0,0) line; in two sources, it is even stronger. Except for the object with the highest mass-loss rate, IRC+10216, the (0, 11c, 0) line covers a smaller velocity range than the (0,0,0) line. The (0, 11d, 0) line, which is detected in four of the sources, is much weaker than the other two lines and covers a velocity range that is smaller yet, again except for IRC+10216. Compared to its first detection in 1989, the profile of the (0, 11c, 0) line observed toward IRC+10216 looks very different, and we also appear to see variability in the (0,0,0) line profile (at a much lower degree). Our limited information on temporal variabilitydisfavors a strong correlation of maser and stellar continuum flux

Genome-Wide Mapping of 5mC and 5hmC Identified Differentially Modified Genomic Regions in Late-Onset Severe Preeclampsia: A Pilot Study.

Directory of Open Access Journals (Sweden)

Lisha Zhu

Full Text Available Preeclampsia (PE is a leading cause of perinatal morbidity and mortality. However, as a common form of PE, the etiology of late-onset PE is elusive. We analyzed 5-methylcytosine (5mC and 5-hydroxymethylcytosine (5hmC levels in the placentas of late-onset severe PE patients (n = 4 and normal controls (n = 4 using a (hydroxymethylated DNA immunoprecipitation approach combined with deep sequencing ([h]MeDIP-seq, and the results were verified by (hMeDIP-qPCR. The most significant differentially methylated regions (DMRs were verified by MassARRAY EppiTYPER in an enlarged sample size (n = 20. Bioinformatics analysis identified 714 peaks of 5mC that were associated with 403 genes and 119 peaks of 5hmC that were associated with 61 genes, thus showing significant differences between the PE patients and the controls (>2-fold, p<0.05. Further, only one gene, PTPRN2, had both 5mC and 5hmC changes in patients. The ErbB signaling pathway was enriched in those 403 genes that had significantly different 5mC level between the groups. This genome-wide mapping of 5mC and 5hmC in late-onset severe PE and normal controls demonstrates that both 5mC and 5hmC play epigenetic roles in the regulation of the disease, but work independently. We reveal the genome-wide mapping of DNA methylation and DNA hydroxymethylation in late-onset PE placentas for the first time, and the identified ErbB signaling pathway and the gene PTPRN2 may be relevant to the epigenetic pathogenesis of late-onset PE.

Physico-Chemical Research on the Sounding Rocket Maser 13

Science.gov (United States)

Lockowandt, Christian; Kemi, Stig; Abrahamsson, Mattias; Florin, Gunnar

MASER is a sounding rocket platform for short-duration microgravity experiments, providing the scientific community with an excellent microgravity tool. The MASER programme has been running by SSC from 1987 and has up to 2012 provided twelve successful flights for microgravity missions with 6-7 minutes of microgravity, the g-level is normally below 1x10-5 g. The MASER 13 is planned to be launched in spring 2015 from Esrange Space Center in Northern Sweden. The rocket will carry four ESA financed experiment modules. The MASER 13 vehicle will be propelled by the 2-stage solid fuel VSB-30 rocket motor, which provided the 390 kg payload with an apogee of 260 km and 6 and a half minutes of microgravity. Swedish Space Corporation carries out the MASER missions for ESA and the program is also available for other customers. The payload comprise four different experiment modules of which three could be defined as physic-chemical research; XRMON-SOL, CDIC-3, MEDI. It also comprises the Maser Service Module and the recovery system. The Service Module provided real-time 5 Mbps down-link of compressed experiment digital video data from the on-board cameras, as well as high-speed housekeeping telemetry data. XRMON-SOL In this experiment the influence of gravity on the formation of an equiaxed microstructure will be investigated. Special attention will be put on the aspect of nucleation, segregation and impingement. The experiment scope is to melt and solidify an AlCu-alloy sample in microgravity. The solidification will be performed in an isothermal environment. The solidification process will be monitored and recorded with X-ray image during the whole flight, images will also be down-linked to ground for real-time monitoring and possible interaction. CDIC-3 The goal is to study in migrogravity the spatio-temporal dynamics of a chemical front travelling in a thin solution layer open to the air and specifically the respective role of Marangoni and density-related hydrodynamic

Lego clocks: building a clock from parts.

Science.gov (United States)

Brunner, Michael; Simons, Mirre J P; Merrow, Martha

2008-06-01

A new finding opens up speculation that the molecular mechanism of circadian clocks in Synechococcus elongatus is composed of multiple oscillator systems (Kitayama and colleagues, this issue, pp. 1513-1521), as has been described in many eukaryotic clock model systems. However, an alternative intepretation is that the pacemaker mechanism-as previously suggested-lies primarily in the rate of ATP hydrolysis by the clock protein KaiC.

VLA observations of a highly symmetric OH maser in a bipolar nebula

International Nuclear Information System (INIS)

Morris, M.; Bowers, P.F.; Turner, B.E.

1982-01-01

The Very Large Array was used to map 1667 MHz OH maser emission from the bipolar nebula OH 231.8+4.2 at 23 distinct velocities within the unusual, 100 km s -1 wide profile. The source is large (approx.10''equivalent3 x 10 17 cm) and well resolved, and displays ordered large-scale velocity gradients. At most velocities, the maser maps display an unmistakable symmetry about the bipolar axis defined by the optical and infrared reflection nebulae. Most of the data can be accounted for by an axisymmetric model in which the measuring OH is concentrated toward the system's equatorial plane and is expanding radially away from the central star. The observation of complete rings of maser emission at some velocities, however, shows that the maser is also present at high latitudes above the equatorial plane. A model which incorporates these features plus other known aspects of bipolar nebulae is presented and discussed

Historical Cost Curves for Hydrogen Masers and Cesium Beam Frequency and Timing Standards

Science.gov (United States)

Remer, D. S.; Moore, R. C.

1985-01-01

Historical cost curves were developed for hydrogen masers and cesium beam standards used for frequency and timing calibration in the Deep Space Network. These curves may be used to calculate the cost of future hydrogen masers or cesium beam standards in either future or current dollars. The cesium beam standards are decreasing in cost by about 2.3% per year since 1966, and hydrogen masers are decreasing by about 0.8% per year since 1978 relative to the National Aeronautics and Space Administration inflation index.

Regulation of circadian clock transcriptional output by CLOCK:BMAL1

Science.gov (United States)

Trott, Alexandra J.

2018-01-01

The mammalian circadian clock relies on the transcription factor CLOCK:BMAL1 to coordinate the rhythmic expression of 15% of the transcriptome and control the daily regulation of biological functions. The recent characterization of CLOCK:BMAL1 cistrome revealed that although CLOCK:BMAL1 binds synchronously to all of its target genes, its transcriptional output is highly heterogeneous. By performing a meta-analysis of several independent genome-wide datasets, we found that the binding of other transcription factors at CLOCK:BMAL1 enhancers likely contribute to the heterogeneity of CLOCK:BMAL1 transcriptional output. While CLOCK:BMAL1 rhythmic DNA binding promotes rhythmic nucleosome removal, it is not sufficient to generate transcriptionally active enhancers as assessed by H3K27ac signal, RNA Polymerase II recruitment, and eRNA expression. Instead, the transcriptional activity of CLOCK:BMAL1 enhancers appears to rely on the activity of ubiquitously expressed transcription factors, and not tissue-specific transcription factors, recruited at nearby binding sites. The contribution of other transcription factors is exemplified by how fasting, which effects several transcription factors but not CLOCK:BMAL1, either decreases or increases the amplitude of many rhythmically expressed CLOCK:BMAL1 target genes. Together, our analysis suggests that CLOCK:BMAL1 promotes a transcriptionally permissive chromatin landscape that primes its target genes for transcription activation rather than directly activating transcription, and provides a new framework to explain how environmental or pathological conditions can reprogram the rhythmic expression of clock-controlled genes. PMID:29300726

Water maser emission from exoplanetary systems

Science.gov (United States)

Cosmovici, C. B.; Pogrebenko, S.

2018-01-01

Since the first discovery of a Jupiter-mass planet in 1995 more than 2000 exo-planets have been found to exist around main sequence stars. The detection techniques are based on the radial velocity method (which involves the measurement of the star's wobbling induced by the gravitational field of the orbiting giant planets) or on transit photometry by using space telescopes (Kepler, Corot, Hubble and Spitzer) outside the absorbing Earth atmosphere. From the ground, as infrared observations are strongly limited by atmospheric absorption, radioastronomy offers almost the only possible way to search for water presence and abundance in the planetary atmospheres of terrestrial-type planets where life may evolve. Following the discovery in 1994 of the first water maser emission in the atmosphere of Jupiter induced by a cometary impact, our measurements have shown that the water maser line at 22 GHz (1.35 cm) can be used as a powerful diagnostic tool for water search outside the solar system, as comets are able to deliver considerable amounts of water to planets raising the fascinating possibility of extraterrestrial life evolution. Thus in 1999 we started the systematic search for water on 35 different targets up to 50 light years away from the Sun. Here we report the first detection of the water maser emission from the exoplanetary systems Epsilon Eridani, Lalande 21185 and Gliese 581. We have shown the peculiar feasibility of water detection and its importance in the search for exoplanetary systems especially for the Astrobiology programs, given the possibility of long period observations using powerful radiotelescopes equipped with adequate spectrometers.

On Estimating the Mass of Keplerian Accretion Disks in H2O Maser Galaxies

Science.gov (United States)

Kuo, C. Y.; Reid, M. J.; Braatz, J. A.; Gao, F.; Impellizzeri, C. M. V.; Chien, W. T.

2018-06-01

H2O maser disks with Keplerian rotation in active galactic nuclei offer a clean way to determine accurate black hole mass and the Hubble constant. An important assumption made in using a Keplerian H2O maser disk for measuring black hole mass and the Hubble constant is that the disk mass is negligible compared to the black hole mass. A simple and useful model of Huré et al. can be used to test this assumption. In that work, the authors apply a linear disk model to a position–dynamical mass diagram and re-analyze position–velocity data from H2O maser disks associated with active galactic nuclei. They claim that a maser disk with nearly perfect Keplerian rotation could have a disk mass comparable to the black hole mass. This would imply that ignoring the effects of disk self-gravity can lead to large systematic errors in the measurement of black hole mass and the Hubble constant. We examine their methods and find that their large estimated disk masses of Keplerian disks are likely the result of their use of projected instead of three-dimensional position and velocity information. To place better constraints on the disk masses of Keplerian maser systems, we incorporate disk self-gravity into a three-dimensional Bayesian modeling program for maser disks and also evaluate constraints based on the physical conditions for disks that support water maser emission. We find that there is little evidence that disk masses are dynamically important at the ≲1% level compared to the black holes.

Simulated Galactic methanol maser distribution to constrain Milky Way parameters

Science.gov (United States)

Quiroga-Nuñez, L. H.; van Langevelde, H. J.; Reid, M. J.; Green, J. A.

2017-08-01

Context. Using trigonometric parallaxes and proper motions of masers associated with massive young stars, the Bar and Spiral Structure Legacy (BeSSeL) survey has reported the most accurate values of the Galactic parameters so far. The determination of these parameters with high accuracy has a widespread impact on Galactic and extragalactic measurements. Aims: This research is aimed at establishing the confidence with which such parameters can be determined. This is relevant for the data published in the context of the BeSSeL survey collaboration, but also for future observations, in particular from the southern hemisphere. In addition, some astrophysical properties of the masers can be constrained, notably the luminosity function. Methods: We have simulated the population of maser-bearing young stars associated with Galactic spiral structure, generating several samples and comparing them with the observed samples used in the BeSSeL survey. Consequently, we checked the determination of Galactic parameters for observational biases introduced by the sample selection. Results: Galactic parameters obtained by the BeSSeL survey do not seem to be biased by the sample selection used. In fact, the published error estimates appear to be conservative for most of the parameters. We show that future BeSSeL data and future observations with southern arrays will improve the Galactic parameters estimates and smoothly reduce their mutual correlation. Moreover, by modeling future parallax data with larger distance values and, thus, greater relative uncertainties for a larger numbers of sources, we found that parallax-distance biasing is an important issue. Hence, using fractional parallax uncertainty in the weighting of the motion data is imperative. Finally, the luminosity function for 6.7 GHz methanol masers was determined, allowing us to estimate the number of Galactic methanol masers.

A geometrical model of VY Canis Majoris for SiO maser lines

International Nuclear Information System (INIS)

Zhou Zhen-Pu; Kaifu, N.

1984-01-01

A new geometrical model of VY CMa is proposed to explain the three-peaked spectra of transition upsilon=1,2 J=1-0 of SiO maser emission. In this model the circumstellar envelope of VY CMa is a rotating disk of gas and dust seen nearly edge-on. The disk consists of two regions: a decelerated steady stream near the photosphere of the star and an accelerated one further away. Other geometries are discussed and eliminated. Calculated profiles of SiO maser lines fit well the observations. It is possible to explain the three-peaked profiles of SiO maser lines emitted by NML Cyg, RR Aql, NML Tau, etc. (orig.)

A Search for Water Maser Emission from Brown Dwarfs and Low-luminosity Young Stellar Objects

Energy Technology Data Exchange (ETDEWEB)

Gómez, José F.; Manjarrez, Guillermo [Instituto de Astrofísica de Andalucía, CSIC, Glorieta de la Astronomía s/n, E-18008 Granada (Spain); Palau, Aina [Instituto de Radioastronomía y Astrofísica, UNAM, P.O. Box 3-72, 58090, Morelia, Michoacán, México (Mexico); Uscanga, Lucero [Departamento de Astronomía, Universidad de Guanajuato, A.P. 144, 36000 Guanajuato, Gto., México (Mexico); Barrado, David, E-mail: jfg@iaa.es [Centro de Astrobiología, INTA-CSIC, PO BOX 28692, ESAC Campus, E-208691 Villanueva de la Cañada, Madrid (Spain)

2017-05-01

We present a survey for water maser emission toward a sample of 44 low-luminosity young objects, comprising (proto-)brown dwarfs, first hydrostatic cores (FHCs), and other young stellar objects (YSOs) with bolometric luminosities lower than 0.4 L {sub ⊙}. Water maser emission is a good tracer of energetic processes, such as mass-loss and/or accretion, and is a useful tool to study these processes with very high angular resolution. This type of emission has been confirmed in objects with L {sub bol} ≳ 1 L {sub ⊙}. Objects with lower luminosities also undergo mass-loss and accretion, and thus, are prospective sites of maser emission. Our sensitive single-dish observations provided a single detection when pointing toward the FHC L1448 IRS 2E. However, follow-up interferometric observations showed water maser emission associated with the nearby YSO L1448 IRS 2 (a Class 0 protostar of L {sub bol} ≃ 3.6–5.3 L {sub ⊙}) and did not find any emission toward L1448 IRS 2E. The upper limits for water maser emission determined by our observations are one order of magnitude lower than expected from the correlation between water maser luminosities and bolometric luminosities found for YSOs. This suggests that this correlation does not hold at the lower end of the (sub)stellar mass spectrum. Possible reasons are that the slope of this correlation is steeper at L {sub bol} ≤ 1 L {sub ⊙} or that there is an absolute luminosity threshold below which water maser emission cannot be produced. Alternatively, if the correlation still stands at low luminosity, the detection rates of masers would be significantly lower than the values obtained in higher-luminosity Class 0 protostars.

Drifts and Environmental Disturbances in Atomic Clock Subsystems: Quantifying Local Oscillator, Control Loop, and Ion Resonance Interactions.

Science.gov (United States)

Enzer, Daphna G; Diener, William A; Murphy, David W; Rao, Shanti R; Tjoelker, Robert L

2017-03-01

Linear ion trap frequency standards are among the most stable continuously operating frequency references and clocks. Depending on the application, they have been operated with a variety of local oscillators (LOs), including quartz ultrastable oscillators, hydrogen-masers, and cryogenic sapphire oscillators. The short-, intermediate-, and long-term stability of the frequency output is a complicated function of the fundamental performances, the time dependence of environmental disturbances, the atomic interrogation algorithm, the implemented control loop, and the environmental sensitivity of the LO and the atomic system components. For applications that require moving these references out of controlled lab spaces and into less stable environments, such as fieldwork or spaceflight, a deeper understanding is needed of how disturbances at different timescales impact the various subsystems of the clock and ultimately the output stability. In this paper, we analyze which perturbations have an impact and to what degree. We also report on a computational model of a control loop, which keeps the microwave source locked to the ion resonance. This model is shown to agree with laboratory measurements of how well the feedback removes various disturbances and also with a useful analytic approach we developed for predicting these impacts.

Interferometric Observations of the SiO High J Transition Maser associated with VY Canis Majoris with the Submillimeter Array

Science.gov (United States)

Shinnaga, H.; Moran, J. M.; Young, K. H.; Ho, P. T. P.

2005-12-01

We imaged the SiO maser emission of J=5-4 in the v=1 state associated with the peculiar red supergiant VY Canis Majoris using the partially completed Submillimeter Array. We identified seven maser components and measured the relative positions at sub-arcsecond scale in the high J transition for the first time. We have also measured the polarization of these maser components. The strongest maser feature has a linear polarization of ˜ 60%, and its direction of polarization is approximately aligned with the bipolar axis. Such a high degree of polarization suggests that radiative pumping is probably responsible for the maser inversion. Five of the other maser features have significant linear polarization.

Relativistic Ideal Clock

OpenAIRE

Bratek, Łukasz

2015-01-01

Two particularly simple ideal clocks exhibiting intrinsic circular motion with the speed of light and opposite spin alignment are described. The clocks are singled out by singularities of an inverse Legendre transformation for relativistic rotators of which mass and spin are fixed parameters. Such clocks work always the same way, no matter how they move. When subject to high accelerations or falling in strong gravitational fields of black holes, the clocks could be used to test the clock hypo...

Traveling-Wave Maser for 32 GHz

Science.gov (United States)

Shell, James; Clauss, Robert

2009-01-01

The figure depicts a traveling-wave ruby maser that has been designed (though not yet implemented in hardware) to serve as a low-noise amplifier for reception of weak radio signals in the frequency band of 31.8 to 32.3 GHz. The design offers significant improvements over previous designs of 32-GHz traveling-wave masers. In addition, relative to prior designs of 32-GHz amplifiers based on high-electron-mobility transistors, this design affords higher immunity to radio-frequency interference and lower equivalent input noise temperature. In addition to the basic frequency-band and low-noise requirements, the initial design problem included a requirement for capability of operation in a closed-cycle helium refrigerator at a temperature .4 K and a requirement that the design be mechanically simplified, relative to prior designs, in order to minimize the cost of fabrication and assembly. Previous attempts to build 32- GHz traveling-wave masers involved the use of metallic slow-wave structures comprising coupled transverse electromagnetic (TEM)-mode resonators that were subject to very tight tolerances and, hence, were expensive to fabricate and assemble. Impedance matching for coupling signals into and out of these earlier masers was very difficult. A key feature of the design is a slow-wave structure, the metallic portions of which would be mechanically relatively simple in that, unlike in prior slow-wave structures, there would be no internal metal steps, irises, or posts. The metallic portions of the slow-wave structure would consist only of two rectangular metal waveguide arms. The arms would contain sections filled with the active material (ruby) alternating with evanescent-wave sections. This structure would be transparent in both the signal-frequency band (the aforementioned range of 31.8 to 32.3 GHz) and the pump-frequency band (65.75 to 66.75 GHz), and would impose large slowing factors in both frequency bands. Resonant ferrite isolators would be placed in the

Clostridium difficile toxin B inhibits the secretory response of human mast cell line-1 (HMC-1) cells stimulated with high free-Ca2+ and GTPγS

International Nuclear Information System (INIS)

Balletta, Andrea; Lorenz, Dorothea; Rummel, Andreas; Gerhard, Ralf; Bigalke, Hans; Wegner, Florian

2015-01-01

Clostridium difficile toxins A and B (TcdA and TcdB) belong to the class of large clostridial cytotoxins and inactivate by glucosylation some low molecular mass GTPases of the Rho-family (predominantly Rho, Rac and Cdc42), known as regulators of the actin cytoskeleton. TcdA and B also represent the main virulence factors of the anaerobic gram-positive bacterium that is the causal agent of pseudomembranous colitis. In our study, TcdB was chosen instead of TcdA for the well-known higher cytotoxic potency. Inactivation of Rho-family GTPases by this toxin in our experimental conditions induced morphological changes and reduction of electron-dense mast cell-specific granules in human mast cell line-1 (HMC-1) cells, but not cell death or permeabilisation of plasma-membranes. Previously reported patch-clamp dialysis experiments revealed that high intracellular free-Ca 2+ and GTPγS concentrations are capable of inducing exocytosis as indicated by significant membrane capacitance (C m ) increases in HMC-1 cells. In this study, we investigated the direct effects of TcdB upon HMC-1 cell “stimulated” C m increase, as well as on “constitutive” secretion of hexosaminidase and interleukin-16 (IL-16). Compared to untreated control cells, HMC-1 cells incubated with TcdB for 3–24 h exhibited a significant reduction of the mean absolute and relative C m increase in response to free-Ca 2+ and GTPγS suggesting an inhibition of secretory processes by TcdB. In conclusion, the HMC-1 cell line represents a suitable model for the study of direct effects of C. difficile toxins on human mast cell secretory activity

Rapid Fluctuations of Water Maser Emission in VY Canis Majoris

Science.gov (United States)

Zheng, Xing Wu; Scalise, Eugenio, Jr.; Han, Fu

1998-11-01

We report the observational results of short timescale monitoring of the 22 GHz water maser emission in VY CMa. A quasi-sinusoidal fluctuation has been detected with the relative flux intensity change of 20%-25% and a period of 10.3 day for two dominant features. This detected variability appears to be superimposed on the normal maser lines. We cannot easily explain the rapid fluctuation with the variation of the radiative input or the strong interstellar scintillation along the line of sight. The variation may be caused by the periodic shock.

Modélisation du comportement et des couplages HMC des milieux poreux

OpenAIRE

Hoang , Ha

2012-01-01

Modelling of the behavior and the couplings HMC of the porous circles; La modélisation du comportement hydromécanique chimique des milieux poreux saturés et non saturés est abordée au niveau microscopique et mésoscopique. Au niveau microscopique la modélisation des écoulements diphasiques est basée sur une représentation du réseau poral comme un ensemble de tubes dont les orientations et les rayons sont choisis sur un principe d’équivalence avec les pores. L’algorithme régissant la génération...

Radio molecular maser line study of symbiotic stars

International Nuclear Information System (INIS)

Cohen, N.L.; Ghigo, F.D.

1980-01-01

A sample of symbiotic stars has been searched for maser emission from the 1665- and 1667-MHz OH mainlines, the 22-GHz H 2 O line, and the 43-GHz SiO line. R Aqr remains the sole symbiotic for which maser emission has been detected. Its SiO spectrum reveals a pedestal of emission with a narrow superposed peak at V/sub LSR/ -26.4 +- 0.7 km/s. The line's existence and the pedestal feature are both characteristic of SiO lines found in late-type variables by Snyder et al. [Astrophys. J. 224, 512 (1978)]. For the other symbiotic stars, it is possible that conditions favorable for maser emission have been suppressed by the presence of a hot companion. Alternatively our findings may argue against the presence of late-type variables in symbiotic stars. In either case, R Aqr seems to be in a class by itself. We cannot confirm the suggestion that R Aqr is a binary, since the spectral feature has not shifted noticeably in the two years since the observations by Lepine, LeSqueren, and Scalise [Astrophys. J. 225, 869 (1978)]. However, we point out that monitoring the pedestal emission over a number of years is the least ambiguous way to discern any velocity shift that might result from orbital motion

Search for electric dipole moment in 129Xe atom using active nuclear spin maser

Directory of Open Access Journals (Sweden)

Ichikawa Y.

2014-03-01

Full Text Available An experimental search for an electric dipole moment in the diamagnetic atom 129Xe is in progress through the precision measurement of spin precession frequency using an active nuclear spin maser. A 3He comagnetometer has been incorporated into the active spin maser system in order to cancel out the long-term drifts in the external magnetic field. Also, a double-cell geometry has been adopted in order to suppress the frequency shifts due to interaction with polarized Rb atoms. The first EDM measurement with the 129Xe active spin maser and the 3He comagnetometer has been conducted.

Multi-Wavelength Studies on H2O Maser Host Galaxies J. S. Zhang ...

Indian Academy of Sciences (India)

on two projects: X-ray data analysis of individual maser source using. X-ray penetrability to explore maser host obscured AGN; multi- wavelength ... Figure 1. Adaptively smoothed three-color image in 0.3–8.0keV and spectra with fitting ... It provides a perspective to improve the accuracy of the Hubble constant H0 and to.

IDENTIFICATION OF BURSTING WATER MASER FEATURES IN ORION KL

International Nuclear Information System (INIS)

Hirota, Tomoya; Honma, Mareki; Kim, Mi Kyoung; Kobayashi, Hideyuki; Shibata, Katsunori M.; Tsuboi, Masato; Fujisawa, Kenta; Kawaguchi, Noriyuki; Imai, Hiroshi; Omodaka, Toshihiro; Shimoikura, Tomomi; Yonekura, Yoshinori

2011-01-01

In 2011 February, a burst event of the H 2 O maser in Orion KL (Kleinmann-Low object) has started after a 13 year silence. This is the third time such phenomena has been detected in Orion KL, followed by the events in 1979-1985 and 1998. We have carried out astrometric observations of the bursting H 2 O maser features in Orion KL with the VLBI Exploration of Radio Astrometry (VERA), a Japanese very long baseline interferometry network dedicated for astrometry. The total flux of the bursting feature at the local standard of rest (LSR) velocity of 7.58 km s -1 reaches 4.4 x 10 4 Jy in 2011 March. The intensity of the bursting feature is three orders of magnitude larger than that of the same velocity feature in the quiescent phase in 2006. Two months later, another new feature appears at the LSR velocity of 6.95 km s -1 in 2011 May, separated by 12 mas north of the 7.58 km s -1 feature. Thus, the current burst occurs at two spatially different features. The bursting masers are elongated along the northwest-southeast direction as reported in the previous burst in 1998. We determine the absolute positions of the bursting features for the first time ever with a submilliarcsecond (mas) accuracy. Their positions are coincident with the shocked molecular gas called the Orion Compact Ridge. We tentatively detect the absolute proper motions of the bursting features toward the southwest direction. It is most likely that the outflow from the radio source I or another young stellar object interacting with the Compact Ridge is a possible origin of the H 2 O maser burst.

Periodic Variations in the Vertical Velocities of Galactic Masers

Directory of Open Access Journals (Sweden)

Bobylev V. V.

2016-03-01

Full Text Available We compiled published data on Galactic masers with VLBI-measured trigonometric parallaxes and determined the residual tangential, ∆Vcirc, and radial, ∆VR, velocities for 120 masers. We used these data to redetermine the parameters of the Galactic spiral density wave using the method of spectral analysis. The most interesting result of this study is the detection of wavelike oscillations of vertical spatial velocities (W versus distance R from the Galactic rotation axis. Spectral analysis allowed us to determine the perturbation wavelength and the amplitude of this wave, which we found to be equal to λW = 3.4 ± 0.7 kpc and fW = 4.9 ± 1.2 km s−1, respectively.

High Precision Clock Bias Prediction Model in Clock Synchronization System

Directory of Open Access Journals (Sweden)

Zan Liu

2016-01-01

Full Text Available Time synchronization is a fundamental requirement for many services provided by a distributed system. Clock calibration through the time signal is the usual way to realize the synchronization among the clocks used in the distributed system. The interference to time signal transmission or equipment failures may bring about failure to synchronize the time. To solve this problem, a clock bias prediction module is paralleled in the clock calibration system. And for improving the precision of clock bias prediction, the first-order grey model with one variable (GM(1,1 model is proposed. In the traditional GM(1,1 model, the combination of parameters determined by least squares criterion is not optimal; therefore, the particle swarm optimization (PSO is used to optimize GM(1,1 model. At the same time, in order to avoid PSO getting stuck at local optimization and improve its efficiency, the mechanisms that double subgroups and nonlinear decreasing inertia weight are proposed. In order to test the precision of the improved model, we design clock calibration experiments, where time signal is transferred via radio and wired channel, respectively. The improved model is built on the basis of clock bias acquired in the experiments. The results show that the improved model is superior to other models both in precision and in stability. The precision of improved model increased by 66.4%~76.7%.

TESTING THE HYPOTHESIS THAT METHANOL MASER RINGS TRACE CIRCUMSTELLAR DISKS: HIGH-RESOLUTION NEAR-INFRARED AND MID-INFRARED IMAGING

International Nuclear Information System (INIS)

De Buizer, James M.; Bartkiewicz, Anna; Szymczak, Marian

2012-01-01

Milliarcsecond very long baseline interferometry maps of regions containing 6.7 GHz methanol maser emission have lead to the recent discovery of ring-like distributions of maser spots and the plausible hypothesis that they may be tracing circumstellar disks around forming high-mass stars. We aimed to test this hypothesis by imaging these regions in the near- and mid-infrared at high spatial resolution and compare the observed emission to the expected infrared morphologies as inferred from the geometries of the maser rings. In the near-infrared we used the Gemini North adaptive optics system of ALTAIR/NIRI, while in the mid-infrared we used the combination of the Gemini South instrument T-ReCS and super-resolution techniques. Resultant images had a resolution of ∼150 mas in both the near-infrared and mid-infrared. We discuss the expected distribution of circumstellar material around young and massive accreting (proto)stars and what infrared emission geometries would be expected for the different maser ring orientations under the assumption that the masers are coming from within circumstellar disks. Based upon the observed infrared emission geometries for the four targets in our sample and the results of spectral energy distribution modeling of the massive young stellar objects associated with the maser rings, we do not find compelling evidence in support of the hypothesis that methanol masers rings reside in circumstellar disks.

Interaction of HmC1q with leech microglial cells: involvement of C1qBP-related molecule in the induction of cell chemotaxis

Directory of Open Access Journals (Sweden)

Tahtouh Muriel

2012-02-01

Full Text Available Abstract Background In invertebrates, the medicinal leech is considered to be an interesting and appropriate model to study neuroimmune mechanisms. Indeed, this non-vertebrate animal can restore normal function of its central nervous system (CNS after injury. Microglia accumulation at the damage site has been shown to be required for axon sprouting and for efficient regeneration. We characterized HmC1q as a novel chemotactic factor for leech microglial cell recruitment. In mammals, a C1q-binding protein (C1qBP alias gC1qR, which interacts with the globular head of C1q, has been reported to participate in C1q-mediated chemotaxis of blood immune cells. In this study, we evaluated the chemotactic activities of a recombinant form of HmC1q and its interaction with a newly characterized leech C1qBP that acts as its potential ligand. Methods Recombinant HmC1q (rHmC1q was produced in the yeast Pichia pastoris. Chemotaxis assays were performed to investigate rHmC1q-dependent microglia migration. The involvement of a C1qBP-related molecule in this chemotaxis mechanism was assessed by flow cytometry and with affinity purification experiments. The cellular localization of C1qBP mRNA and protein in leech was investigated using immunohistochemistry and in situ hybridization techniques. Results rHmC1q-stimulated microglia migrate in a dose-dependent manner. This rHmC1q-induced chemotaxis was reduced when cells were preincubated with either anti-HmC1q or anti-human C1qBP antibodies. A C1qBP-related molecule was characterized in leech microglia. Conclusions A previous study showed that recruitment of microglia is observed after HmC1q release at the cut end of axons. Here, we demonstrate that rHmC1q-dependent chemotaxis might be driven via a HmC1q-binding protein located on the microglial cell surface. Taken together, these results highlight the importance of the interaction between C1q and C1qBP in microglial activation leading to nerve repair in the medicinal

Interaction of HmC1q with leech microglial cells: involvement of C1qBP-related molecule in the induction of cell chemotaxis.

Science.gov (United States)

Tahtouh, Muriel; Garçon-Bocquet, Annelise; Croq, Françoise; Vizioli, Jacopo; Sautière, Pierre-Eric; Van Camp, Christelle; Salzet, Michel; Nagnan-le Meillour, Patricia; Pestel, Joël; Lefebvre, Christophe

2012-02-22

In invertebrates, the medicinal leech is considered to be an interesting and appropriate model to study neuroimmune mechanisms. Indeed, this non-vertebrate animal can restore normal function of its central nervous system (CNS) after injury. Microglia accumulation at the damage site has been shown to be required for axon sprouting and for efficient regeneration. We characterized HmC1q as a novel chemotactic factor for leech microglial cell recruitment. In mammals, a C1q-binding protein (C1qBP alias gC1qR), which interacts with the globular head of C1q, has been reported to participate in C1q-mediated chemotaxis of blood immune cells. In this study, we evaluated the chemotactic activities of a recombinant form of HmC1q and its interaction with a newly characterized leech C1qBP that acts as its potential ligand. Recombinant HmC1q (rHmC1q) was produced in the yeast Pichia pastoris. Chemotaxis assays were performed to investigate rHmC1q-dependent microglia migration. The involvement of a C1qBP-related molecule in this chemotaxis mechanism was assessed by flow cytometry and with affinity purification experiments. The cellular localization of C1qBP mRNA and protein in leech was investigated using immunohistochemistry and in situ hybridization techniques. rHmC1q-stimulated microglia migrate in a dose-dependent manner. This rHmC1q-induced chemotaxis was reduced when cells were preincubated with either anti-HmC1q or anti-human C1qBP antibodies. A C1qBP-related molecule was characterized in leech microglia. A previous study showed that recruitment of microglia is observed after HmC1q release at the cut end of axons. Here, we demonstrate that rHmC1q-dependent chemotaxis might be driven via a HmC1q-binding protein located on the microglial cell surface. Taken together, these results highlight the importance of the interaction between C1q and C1qBP in microglial activation leading to nerve repair in the medicinal leech.

EVOLUTION OF THE WATER MASER EXPANDING SHELL IN W75N VLA 2

Energy Technology Data Exchange (ETDEWEB)

Kim, Jeong-Sook; Kim, Sang Joon [School of Space Science, Kyunghee University, Seocheon-dong, Giheung-si, Gyeonggi-do, 446-701 (Korea, Republic of); Kim, Soon-Wook [Korea Astronomy and Space Science Institute, 776 Daedeokdaero, Yuseong, Daejeon 305-348 (Korea, Republic of); Kurayama, Tomoharu [Graduate School of Science and Engineering, Kagoshima University, 1-21-35 Korimoto, Kagoshima, Kagoshima 890-0065 (Japan); Honma, Mareki [National Astronomical Observatory of Japan, 2-21-1 Osawa, Mitaka, Tokyo 181-8588 (Japan); Sasao, Tesuo [Yaeyama Star Club, Ookawa, Ishigaki, Okinawa 904-0022 (Japan); Surcis, Gabriele [Joint Institute for VLBI in Europe, Postbus 2, 7990 AA Dwingeloo (Netherlands); Canto, Jorge [Instituto de Astronomia (UNAM), Apartado 70-264, 04510 Mexico D. F. (Mexico); Torrelles, Jose M., E-mail: evony@kasi.re.kr, E-mail: skim@kasi.re.kr [Instituto de Ciencias del Espacio (CSIC)-UB/IEEC, Universitat de Barcelona, Marti i Franques 1, E-08028 Barcelona (Spain)

2013-04-10

We present Very Long Baseline Interferometry (VLBI) observations of 22 GHz H{sub 2}O masers in the high-mass star-forming region of W75N, carried out with VLBI Exploration of Radio Astrometry (VERA) for three epochs in 2007 with an angular resolution of {approx}1 mas. We detected H{sub 2}O maser emission toward the radio jet in VLA 1 and the expanding shell-like structure in VLA 2. The spatial distribution of the H{sub 2}O masers detected with VERA and measured proper motions around VLA 1 and VLA 2 are similar to those found with previous VLBI observations in epochs 1999 and 2005, with the masers in VLA 1 mainly distributed along a linear structure parallel to the radio jet and, on the other hand, forming a shell-like structure around VLA 2. We have made elliptical fits to the VLA 2 H{sub 2}O maser shell-like structure observed in the different epochs (1999, 2005, and 2007), and found that the shell is still expanding eight years after its discovery. From the difference in the size of the semi-major axes of the fitted ellipses in epochs 1999 ({approx_equal}71 {+-} 1 mas), 2005 ({approx_equal}97 {+-} 3 mas), and 2007 ({approx_equal}111 {+-} 1 mas), we estimate an average expanding velocity of {approx}5 mas yr{sup -1}, similar to the proper motions measured in the individual H{sub 2}O maser features. A kinematic age of {approx}20 yr is derived for this structure. In addition, our VERA observations indicate an increase in the ellipticity of the expanding shell around VLA 2 from epochs 1999 to 2007. In fact, the elliptical fit of the VERA data shows a ratio of the minor and major axes of {approx}0.6, in contrast with an almost circular shape for the shell detected in 1999 and 2005 (b/a {approx} 0.9). This suggests that we are probably observing the formation of a jet-driven H{sub 2}O maser structure in VLA2, evolving from a non-collimated pulsed-outflow event during the first stages of evolution of a massive young stellar object (YSO). This may support predictions made

Tianma 65-m telescope detection of new OH maser features towards the water fountain source IRAS 18286-0959

Science.gov (United States)

Chen, Xi; Shen, Zhi-Qiang; Li, Xiao-Qiong; Yang, Kai; Nakashima, Jun-ichi; Wu, Ya-Jun; Zhao, Rong-Bin; Li, Juan; Wang, Jun-Zhi; Jiang, Dong-Rong; Wang, Jin-Qing; Li, Bin; Zhong, Wei-Ye; Yung, Bosco H. K.

2017-07-01

We report the results of the OH maser observation towards the water fountain source IRAS 18286-0959 using the newly built Shanghai Tianma 65-m Radio Telescope. We observed the three OH ground state transition lines at frequencies of 1612, 1665 and 1667 MHz. Comparing with the spectra of previous observations, we find new maser spectral components at velocity channels largely shifted from the systemic velocity: the velocity offsets of the newly found components lie in the range 20-40 km s-1 with respect to the systemic velocity. Besides maser variability, another possible interpretation for the newly detected maser features is that part of the molecular gas in the circumstellar envelope is accelerated. The acceleration is probably caused by the passage of a high-velocity molecular jet, which has been detected in previous Very Long Baseline Interferometry observations in the H2O maser line.

Polarisation observations of VY Canis Majoris H2O 532-441 620.701 GHz maser emission with HIFI

Science.gov (United States)

Harwit, M.; Houde, M.; Sonnentrucker, P.; Boogert, A. C. A.; Cernicharo, J.; De Beck, E.; Decin, L.; Henkel, C.; Higgins, R. D.; Jellema, W.; Kraus, A.; McCoey, C.; Melnick, G. J.; Menten, K. M.; Risacher, C.; Teyssier, D.; Vaillancourt, J. E.; Alcolea, J.; Bujarrabal, V.; Dominik, C.; Justtanont, K.; de Koter, A.; Marston, A. P.; Olofsson, H.; Planesas, P.; Schmidt, M.; Schöier, F. L.; Szczerba, R.; Waters, L. B. F. M.

2010-10-01

Context. Water vapour maser emission from evolved oxygen-rich stars remains poorly understood. Additional observations, including polarisation studies and simultaneous observation of different maser transitions may ultimately lead to greater insight. Aims: We have aimed to elucidate the nature and structure of the VY CMa water vapour masers in part by observationally testing a theoretical prediction of the relative strengths of the 620.701 GHz and the 22.235 GHz maser components of ortho H2O. Methods: In its high-resolution mode (HRS) the Herschel Heterodyne Instrument for the Far Infrared (HIFI) offers a frequency resolution of 0.125 MHz, corresponding to a line-of-sight velocity of 0.06 km s-1, which we employed to obtain the strength and linear polarisation of maser spikes in the spectrum of VY CMa at 620.701 GHz. Simultaneous ground based observations of the 22.235 GHz maser with the Max-Planck-Institut für Radioastronomie 100-m telescope at Effelsberg, provided a ratio of 620.701 GHz to 22.235 GHz emission. Results: We report the first astronomical detection to date of H2O maser emission at 620.701 GHz. In VY CMa both the 620.701 and the 22.235 GHz polarisation are weak. At 620.701 GHz the maser peaks are superposed on what appears to be a broad emission component, jointly ejected from the star. We observed the 620.701 GHz emission at two epochs 21 days apart, both to measure the potential direction of linearly polarised maser components and to obtain a measure of the longevity of these components. Although we do not detect significant polarisation levels in the core of the line, they rise up to approximately 6% in its wings. Herschel is an ESA space observatory with science instruments provided by European-led Principal Investigator consortia and with important participation from NASA.Appendix (page 5) is only available in electronic form at http://www.aanda.org

Dust Grains and the Luminosity of Circumnuclear Water Masers in Active Galaxies

Science.gov (United States)

Collison, Alan J.; Watson, William D.

1995-01-01

In previous calculations for the luminosities of 22 GHz water masers, the pumping is reduced and ultimately quenched with increasing depth into the gas because of trapping of the infrared (approximately equals 30-150 micrometers), spectral line radiation of the water molecule. When the absorption (and reemission) of infrared radiation by dust grains is included, we demonstrate that the pumping is no longer quenched but remains constant with increasing optical depth. A temperature difference between the grains and the gas is required. Such conditions are expected to occur, for example, in the circumnuclear masing environments created by X-rays in active galaxies. Here, the calculated 22 GHz maser luminosities are increased by more than an order of magnitude. Application to the well-studied, circumnuclear masing disk in the galaxy NGC 4258 yields a maser luminosity near that inferred from observations if the observed X-ray flux is assumed to be incident onto only the inner surface of the disk.

Clock Drawing in Spatial Neglect: A Comprehensive Analysis of Clock Perimeter, Placement, and Accuracy

Science.gov (United States)

Chen, Peii; Goedert, Kelly M.

2012-01-01

Clock drawings produced by right-brain-damaged (RBD) individuals with spatial neglect often contain an abundance of empty space on the left while numbers and hands are placed on the right. However, the clock perimeter is rarely compromised in neglect patients’ drawings. By analyzing clock drawings produced by 71 RBD and 40 healthy adults, this study investigated whether the geometric characteristics of the clock perimeter reveal novel insights to understanding spatial neglect. Neglect participants drew smaller clocks than either healthy or non-neglect RBD participants. While healthy participants’ clock perimeter was close to circular, RBD participants drew radially extended ellipses. The mechanisms for these phenomena were investigated by examining the relation between clock-drawing characteristics and performance on six subtests of the Behavioral Inattention Test (BIT). The findings indicated that the clock shape was independent of any BIT subtest or the drawing placement on the test sheet and that the clock size was significantly predicted by one BIT subtest: the poorer the figure and shape copying, the smaller the clock perimeter. Further analyses revealed that in all participants, clocks decreased in size as they were placed farther from the center of the paper. However, even when neglect participants placed their clocks towards the center of the page, they were smaller than those produced by healthy or non-neglect RBD participants. These results suggest a neglect-specific reduction in the subjectively available workspace for graphic production from memory, consistent with the hypothesis that neglect patients are impaired in the ability to enlarge the attentional aperture. PMID:22390278

An improved method for measuring the magnetic inhomogeneity shift in hydrogen masers

Science.gov (United States)

Reinhardt, V. S.; Peters, H. E.

1975-01-01

The reported method makes it possible to conduct all maser frequency measurements under conditions of low magnetic field intensity for which the hydrogen maser is most stable. Aspects concerning the origin of the magnetic inhomogeneity shift are examined and the available approaches for measuring this shift are considered, taking into account certain drawbacks of currently used methods. An approach free of these drawbacks can be based on the measurement of changes in a parameter representing the difference between the number of atoms in the involved states.

OH masers associated with IRAS point sources

NARCIS (Netherlands)

Masheder, MRW; Cohen, RJ; Martin-Hernandez, NL; Migenes,; Reid, MJ

2002-01-01

We report a search for masers from the Lambda-doublet of the ground-state of OH at 18cm, carried out with the Jodrell Bank Lovell Telescope and with the 25m Dwingeloo telescope. All objects north of delta = -20degrees which appear in the IRAS Point Source Catalog with fluxes > 1000 Jy at 60mum and

A GPS Satellite Clock Offset Prediction Method Based on Fitting Clock Offset Rates Data

Directory of Open Access Journals (Sweden)

WANG Fuhong

2016-12-01

Full Text Available It is proposed that a satellite atomic clock offset prediction method based on fitting and modeling clock offset rates data. This method builds quadratic model or linear model combined with periodic terms to fit the time series of clock offset rates, and computes the model coefficients of trend with the best estimation. The clock offset precisely estimated at the initial prediction epoch is directly adopted to calculate the model coefficient of constant. The clock offsets in the rapid ephemeris (IGR provided by IGS are used as modeling data sets to perform certain experiments for different types of GPS satellite clocks. The results show that the clock prediction accuracies of the proposed method for 3, 6, 12 and 24 h achieve 0.43, 0.58, 0.90 and 1.47 ns respectively, which outperform the traditional prediction method based on fitting original clock offsets by 69.3%, 61.8%, 50.5% and 37.2%. Compared with the IGU real-time clock products provided by IGS, the prediction accuracies of the new method have improved about 15.7%, 23.7%, 27.4% and 34.4% respectively.

Stochastic motion from a forced plasma-maser interaction

International Nuclear Information System (INIS)

Honjo, Haruo; Nambu, Mitsuhiro

1986-01-01

A model of forced plasma-maser effects is examined numerically. The model represents a conservative system and reduces to the forced type of the original Lotka-Volterra equation. A stochastic motion is found to occur when the density of a cold ion beam becomes larger. (author)

Time Variations of the Radial Velocity of H2O Masers in the Semi-Regular Variable R Crt

Science.gov (United States)

Sudou, Hiroshi; Shiga, Motoki; Omodaka, Toshihiro; Nakai, Chihiro; Ueda, Kazuki; Takaba, Hiroshi

2017-12-01

H2O maser emission {at 22 GHz} in the circumstellar envelope is one of the good tracers of detailed physics and inematics in the mass loss process of asymptotic giant branch stars. Long-term monitoring of an H2O maser spectrum with high time resolution enables us to clarify acceleration processes of the expanding shell in the stellar atmosphere. We monitored the H2O maser emission of the semi-regular variable R Crt with the Kagoshima 6-m telescope, and obtained a large data set of over 180 maser spectra over a period of 1.3 years with an observational span of a few days. Using an automatic peak detection method based on least-squares fitting, we exhaustively detected peaks as significant velocity components with the radial velocity on a 0.1 km s^{-1} scale. This analysis result shows that the radial velocity of red-shifted and blue-shifted components exhibits a change between acceleration and deceleration on the time scale of a few hundred days. These velocity variations are likely to correlate with intensity variations, in particular during flaring state of H2O masers. It seems reasonable to consider that the velocity variation of the maser source is caused by shock propagation in the envelope due to stellar pulsation.However, it is difficult to explain the relationship between the velocity variation and the intensity variation only from shock propagation effects. We found that a time delay of the integrated maser intensity with respect to the optical light curve is about 150 days.

Prediction of GNSS satellite clocks

International Nuclear Information System (INIS)

Broederbauer, V.

2010-01-01

This thesis deals with the characterisation and prediction of GNSS-satellite-clocks. A prerequisite to develop powerful algorithms for the prediction of clock-corrections is the thorough study of the behaviour of the different clock-types of the satellites. In this context the predicted part of the IGU-clock-corrections provided by the Analysis Centers (ACs) of the IGS was compared to the IGS-Rapid-clock solutions to determine reasonable estimates of the quality of already existing well performing predictions. For the shortest investigated interval (three hours) all ACs obtain almost the same accuracy of 0,1 to 0,4 ns. For longer intervals the individual predictions results start to diverge. Thus, for a 12-hours- interval the differences range from nearly 10 ns (GFZ, CODE) until up to some 'tens of ns'. Based on the estimated clock corrections provided via the IGS Rapid products a simple quadratic polynomial turns out to be sufficient to describe the time series of Rubidium-clocks. On the other hand Cesium-clocks show a periodical behaviour (revolution period) with an amplitude of up to 6 ns. A clear correlation between these amplitudes and the Sun elevation angle above the orbital planes can be demonstrated. The variability of the amplitudes is supposed to be caused by temperature-variations affecting the oscillator. To account for this periodical behaviour a quadratic polynomial with an additional sinus-term was finally chosen as prediction model both for the Cesium as well as for the Rubidium clocks. The three polynomial-parameters as well as amplitude and phase shift of the periodic term are estimated within a least-square-adjustment by means of program GNSS-VC/static. Input-data are time series of the observed part of the IGU clock corrections. With the estimated parameters clock-corrections are predicted for various durations. The mean error of the prediction of Rubidium-clock-corrections for an interval of six hours reaches up to 1,5 ns. For the 12-hours

DISCOVERY OF CANDIDATE H2O DISK MASERS IN ACTIVE GALACTIC NUCLEI AND ESTIMATIONS OF CENTRIPETAL ACCELERATIONS

International Nuclear Information System (INIS)

Greenhill, Lincoln J.; Moran, James M.; Tilak, Avanti; Kondratko, Paul T.

2009-01-01

Based on spectroscopic signatures, about one-third of known H 2 O maser sources in active galactic nuclei (AGNs) are believed to arise in highly inclined accretion disks around central engines. These 'disk maser candidates' are of interest primarily because angular structure and rotation curves can be resolved with interferometers, enabling dynamical study. We identify five new disk maser candidates in studies with the Green Bank Telescope, bringing the total number published to 30. We discovered two (NGC 1320, NGC 17) in a survey of 40 inclined active galaxies (v sys -1 ). The remaining three disk maser candidates were identified in monitoring of known sources: NGC 449, NGC 2979, and NGC 3735. We also confirm a previously marginal case in UGC 4203. For the disk maser candidates reported here, inferred rotation speeds are 130-500 km s -1 . Monitoring of three more rapidly rotating candidate disks (CG 211, NGC 6264, VV 340A) has enabled measurement of likely orbital centripetal acceleration, and estimation of central masses ((2-7) x10 7 M sun ) and mean disk radii (0.2-0.4 pc). Accelerations may ultimately permit estimation of distances when combined with interferometer data. This is notable because the three AGNs are relatively distant (10,000 km s -1 sys -1 ), and fractional error in a derived Hubble constant, due to peculiar motion of the galaxies, would be small. As signposts of highly inclined geometries at galactocentric radii of ∼0.1-1 pc, disk masers also provide robust orientation references that allow analysis of (mis)alignment between AGNs and surrounding galactic stellar disks, even without extensive interferometric mapping. We find no preference among published disk maser candidates to lie in high-inclination galaxies. This provides independent support for conclusions that in late-type galaxies, central engine accretion disks and galactic plane orientations are not correlated.

Circumstellar envelopes seen in radio (OH masers) and in the infrared observations (IRAS)

International Nuclear Information System (INIS)

David, Pedro-Correia-de-Matos

1992-01-01

Intermediate mass stars, namely from one to nine solar masses, eject mass into the surrounding interstellar medium at high rates (up to 1/10000 solar masses per year) in their late stages of evolution on the so called asymptotic giant branch (AGB). Indeed, the presence of a circumstellar envelope (CSE) composed of dust and gas is one of the principal features of the objects on the AGB. Because of the high opacity at visible wavelength of the CSE, most of these objects can only be observed at infrared and radio frequencies. This study was undertaken using infrared and radio data from a large sample of CSE sources. The infrared data was obtained from the infrared astronomical satellite (IRAS) data base. For a selection of IRAS objects, radio observations were made of the OH maser at 1612 and 1667 MHz at the Nancay radio telescope, France. This work consists in two parts, one is theoretical in nature, the other observational. The theoretical part is concerned with the modeling of IRAS low resolution spectra (LRS catalog) and IRAS photometry through the use of a radiative transfer code. Confrontation between models and data has yielded such results as a better definition of the grain optical properties and the behavior of the CSE as it evolves. A model of a shock wave (a possible lifting engine of the CSE) propagating in the atmosphere of Mira stars (AGB) is described. On the observational side, a large number of objects has been surveyed for the presence of OH masers at 1612 and 1667 MHz. A statistical analysis has established more clearly the evolutionary status of CSE and the OH maser characteristics. A compiling of detection rates for the occurrence of masers, average location of these masing CSEs in the Galaxy, and OH maser characteristics is reported for use in future work. (author) [fr

Cryogenic H maser in a strong B field

NARCIS (Netherlands)

Maan, A.C.; Tiesinga, E.; Stoof, H.T.C.; Verhaar, B.J.

1990-01-01

We study the spin-exchange frequency shift of the cryogenic hydrogen maser for B≠0. A general expression is derived in terms of populations of ground-state hyperfine levels. The coefficients in this expression are calculated in the degenerate-internal-states approximation, as well as to first order

ALMA sub-mm maser and dust distribution of VY Canis Majoris

Science.gov (United States)

Richards, A. M. S.; Impellizzeri, C. M. V.; Humphreys, E. M.; Vlahakis, C.; Vlemmings, W.; Baudry, A.; De Beck, E.; Decin, L.; Etoka, S.; Gray, M. D.; Harper, G. M.; Hunter, T. R.; Kervella, P.; Kerschbaum, F.; McDonald, I.; Melnick, G.; Muller, S.; Neufeld, D.; O'Gorman, E.; Parfenov, S. Yu.; Peck, A. B.; Shinnaga, H.; Sobolev, A. M.; Testi, L.; Uscanga, L.; Wootten, A.; Yates, J. A.; Zijlstra, A.

2014-12-01

Aims: Cool, evolved stars have copious, enriched winds. Observations have so far not fully constrained models for the shaping and acceleration of these winds. We need to understand the dynamics better, from the pulsating stellar surface to ~10 stellar radii, where radiation pressure on dust is fully effective. Asymmetric nebulae around some red supergiants imply the action of additional forces. Methods: We retrieved ALMA Science Verification data providing images of sub-mm line and continuum emission from VY CMa. This enables us to locate water masers with milli-arcsec accuracy and to resolve the dusty continuum. Results: The 658, 321, and 325 GHz masers lie in irregular, thick shells at increasing distances from the centre of expansion. For the first time this is confirmed as the stellar position, coinciding with a compact peak offset to the NW of the brightest continuum emission. The maser shells overlap but avoid each other on scales of up to 10 au. Their distribution is broadly consistent with excitation models but the conditions and kinematics are complicated by wind collisions, clumping, and asymmetries. Appendices are available in electronic form at http://www.aanda.org

Interferometric Observation of the Highly Polarized SiO Maser Emission from the v = 1, J = 5-4 Transition Associated with VY Canis Majoris

Science.gov (United States)

Shinnaga, Hiroko; Moran, James M.; Young, Ken H.; Ho, Paul T. P.

2004-11-01

We used the Submillimeter Array to image the SiO maser emission in the v=1, J=5-4 transition associated with the peculiar red supergiant VY Canis Majoris. We identified seven maser components and measured their relative positions and linear polarization properties. Five of the maser components are coincident to within about 150 mas (~200 AU at the distance of 1.5 kpc); most of them may originate in the circumstellar envelope at a radius of about 50 mas from the star along with the SiO masers in the lowest rotational transitions. Our measurements show that two of the maser components may be offset from the inner stellar envelope (at the 3 σ level of significance) and may be part of a larger bipolar outflow associated with VY CMa identified by Shinnaga et al. The strongest maser feature at a velocity of 35.9 km s-1 has a 60% linear polarization, and its polarization direction is aligned with the bipolar axis. Such a high degree of polarization suggests that maser inversion is due to radiative pumping. Five of the other maser features have significant linear polarization.

On the Relation of Silicates and SiO Maser in Evolved Stars

Energy Technology Data Exchange (ETDEWEB)

Liu, Jiaming; Jiang, Biwei, E-mail: bjiang@bnu.edu.cn [Department of Astronomy, Beijing Normal University, Beijing 100875 (China)

2017-04-01

The SiO molecule is one of the candidates for the seed of silicate dust in the circumstellar envelope of evolved stars, but this opinion is challenged. In this work we investigate the relation of the SiO maser emission power and the silicate dust emission power. With both our own observation by using the PMO/Delingha 13.7 m telescope and archive data, a sample is assembled of 21 SiO v  = 1, J  = 2 − 1 sources and 28 SiO v  = 1, J  = 1 − 0 sources that exhibit silicate emission features in the ISO /SWS spectrum as well. The analysis of their SiO maser and silicate emission power indicates a clear correlation, which is not against the hypothesis that the SiO molecules are the seed nuclei of silicate dust. On the other hand, no correlation is found between SiO maser and silicate crystallinity, which may imply that silicate crystallinity does not correlate with mass-loss rate.

Modeling of the hydrogen maser disk in MWC 349

Science.gov (United States)

Ponomarev, Victor O.; Smith, Howard A.; Strelnitski, Vladimir S.

1994-04-01

Maser amplification in a Keplerian circumstellar disk seen edge on-the idea put forward by Gordon (1992), Martin-Pintado, & Serabyn (1992), and Thum, Martin-Pintado, & Bachiller (1992) to explain the millimeter hydrogen recombination lines in MWC 349-is further justified and developed here. The double-peaked (vs. possible triple-peaked) form of the observed spectra is explained by the reduced emission from the inner portion of the disk, the portion responsible for the central ('zero velocity') component of a triple-peaked spectrum. Radial gradient of electron density and/or free-free absorption within the disk are identified as the probable causes of this central 'hole' in the disk and of its opacity. We calculate a set of synthetic maser spectra radiated by a homogeneous Keplerian ring seen edge-on and compare them to the H30-alpha observations of Thum et al., averaged over about 1000 days. We used a simple graphical procedure to solve an inverse problem and deduced the probable values of some basic disk and maser parameters. We find that the maser is essentially unsaturated, and that the most probable values of electron temperature. Doppler width of the microturbulence, and electron density, all averaged along the amplification path are, correspondingly, Te less than or equal to 11,000 K, Vmicro less than or equal to 14 km/s, ne approx. = (3 +/- 2) x 107/cu cm. The model shows that radiation at every frequency within the spectrum arises in a monochromatic 'hot spot.' The maximum optical depth within the 'hot spot' producing radiation at the spectral peak maximum is taumax approx. = 6 +/- 1; the effective width of the masing ring is approx. = 0.4-0.7 times its outer diameter; the size of the 'hot spot' responsible for the radiation at the spectral peak frequency is approx. = 0.2-0.3 times the distance between the two 'hot spots' corresponding to two peaks. An important derivation of our model is the dynamical mass of the central star, M* approx. = 26 solar masses

Physiological links of circadian clock and biological clock of aging.

Science.gov (United States)

Liu, Fang; Chang, Hung-Chun

2017-07-01

Circadian rhythms orchestrate biochemical and physiological processes in living organisms to respond the day/night cycle. In mammals, nearly all cells hold self-sustained circadian clocks meanwhile couple the intrinsic rhythms to systemic changes in a hierarchical manner. The suprachiasmatic nucleus (SCN) of the hypothalamus functions as the master pacemaker to initiate daily synchronization according to the photoperiod, in turn determines the phase of peripheral cellular clocks through a variety of signaling relays, including endocrine rhythms and metabolic cycles. With aging, circadian desynchrony occurs at the expense of peripheral metabolic pathologies and central neurodegenerative disorders with sleep symptoms, and genetic ablation of circadian genes in model organisms resembled the aging-related features. Notably, a number of studies have linked longevity nutrient sensing pathways in modulating circadian clocks. Therapeutic strategies that bridge the nutrient sensing pathways and circadian clock might be rational designs to defy aging.

Asymptotic inference in system identification for the atom maser.

Science.gov (United States)

Catana, Catalin; van Horssen, Merlijn; Guta, Madalin

2012-11-28

System identification is closely related to control theory and plays an increasing role in quantum engineering. In the quantum set-up, system identification is usually equated to process tomography, i.e. estimating a channel by probing it repeatedly with different input states. However, for quantum dynamical systems such as quantum Markov processes, it is more natural to consider the estimation based on continuous measurements of the output, with a given input that may be stationary. We address this problem using asymptotic statistics tools, for the specific example of estimating the Rabi frequency of an atom maser. We compute the Fisher information of different measurement processes as well as the quantum Fisher information of the atom maser, and establish the local asymptotic normality of these statistical models. The statistical notions can be expressed in terms of spectral properties of certain deformed Markov generators, and the connection to large deviations is briefly discussed.

A new 3D maser code applied to flaring events

Science.gov (United States)

Gray, M. D.; Mason, L.; Etoka, S.

2018-06-01

We set out the theory and discretization scheme for a new finite-element computer code, written specifically for the simulation of maser sources. The code was used to compute fractional inversions at each node of a 3D domain for a range of optical thicknesses. Saturation behaviour of the nodes with regard to location and optical depth was broadly as expected. We have demonstrated via formal solutions of the radiative transfer equation that the apparent size of the model maser cloud decreases as expected with optical depth as viewed by a distant observer. Simulations of rotation of the cloud allowed the construction of light curves for a number of observable quantities. Rotation of the model cloud may be a reasonable model for quasi-periodic variability, but cannot explain periodic flaring.

Entanglement of quantum clocks through gravity.

Science.gov (United States)

Castro Ruiz, Esteban; Giacomini, Flaminia; Brukner, Časlav

2017-03-21

In general relativity, the picture of space-time assigns an ideal clock to each world line. Being ideal, gravitational effects due to these clocks are ignored and the flow of time according to one clock is not affected by the presence of clocks along nearby world lines. However, if time is defined operationally, as a pointer position of a physical clock that obeys the principles of general relativity and quantum mechanics, such a picture is, at most, a convenient fiction. Specifically, we show that the general relativistic mass-energy equivalence implies gravitational interaction between the clocks, whereas the quantum mechanical superposition of energy eigenstates leads to a nonfixed metric background. Based only on the assumption that both principles hold in this situation, we show that the clocks necessarily get entangled through time dilation effect, which eventually leads to a loss of coherence of a single clock. Hence, the time as measured by a single clock is not well defined. However, the general relativistic notion of time is recovered in the classical limit of clocks.

The Aorta-Gonad-Mesonephros Organ Culture Recapitulates 5hmC Reorganization and Replication-Dependent and Independent Loss of DNA Methylation in the Germline.

Science.gov (United States)

Calvopina, Joseph Hargan; Cook, Helene; Vincent, John J; Nee, Kevin; Clark, Amander T

2015-07-01

Removal of cytosine methylation from the genome is critical for reprogramming and transdifferentiation and plays a central role in our understanding of the fundamental principles of embryo lineage development. One of the major models for studying cytosine demethylation is the mammalian germ line during the primordial germ cell (PGC) stage of embryo development. It is now understood that oxidation of 5-methylcytosine (5mC) to 5-hydroxymethylcytosine (5hmC) is required to remove cytosine methylation in a locus-specific manner in PGCs; however, the mechanisms downstream of 5hmC are controversial and hypothesized to involve either active demethylation or replication-coupled loss. In the current study, we used the aorta-gonad-mesonephros (AGM) organ culture model to show that this model recapitulates germ line reprogramming, including 5hmC reorganization and loss of cytosine methylation from Snrpn and H19 imprinting control centers (ICCs). To directly address the hypothesis that cell proliferation is required for cytosine demethylation, we blocked PI3-kinase-dependent PGC proliferation and show that this leads to a G1 and G2/M cell cycle arrest in PGCs, together with retained levels of cytosine methylation at the Snrpn ICC, but not at the H19 ICC. Taken together, the AGM organ culture model is an important tool to evaluate mechanisms of locus-specific demethylation and the role of PI3-kinase-dependent PGC proliferation in the locus-specific removal of cytosine methylation from the genome.

An Electrostatic Free-Electron Maser for Fusion - Design Considerations

NARCIS (Netherlands)

van Amersfoort, P. W.; Urbanus, W. H.; Verhoeven, A. G. A.; Verheul, A.; Sterk, A. B.; Vaningen, A. M.; van der Wiel, M. J.

1991-01-01

For the next generation of large tokamaks, efficient mm-wave sources at frequencies of up to 300 GHz and unit size of 1 MW cw will be required. The design of a free electron maser for this application, based on a dc electrostatic accelerator, is discussed.

A Light Clock Satisfying the Clock Hypothesis of Special Relativity

Science.gov (United States)

West, Joseph

2007-01-01

The design of the FMEL, a floor-mirrored Einstein-Langevin "light clock", is introduced. The clock provides a physically intuitive manner to calculate and visualize the time dilation effects for a spatially extended set of observers (an accelerated "frame") undergoing unidirectional acceleration or observers on a rotating cylinder of constant…

CEPHEID VARIABLES IN THE MASER-HOST GALAXY NGC 4258

Energy Technology Data Exchange (ETDEWEB)

Hoffmann, Samantha L.; Macri, Lucas M., E-mail: lmacri@tamu.edu [George P. and Cynthia Woods Mitchell Institute for Fundamental Physics and Astronomy, Department of Physics and Astronomy, Texas A and M University, College Station, TX 77843 (United States)

2015-06-15

We present results of a ground-based survey for Cepheid variables in NGC 4258. This galaxy plays a key role in the Extragalactic Distance Scale due to its very precise and accurate distance determination via very long baseline interferometry observations of water masers. We imaged two fields within this galaxy using the Gemini North telescope and the Gemini Multi-Object Spectrograph, obtaining 16 epochs of data in the Sloan Digital Sky Survey gri bands over 4 yr. We carried out point-spread function photometry and detected 94 Cepheids with periods between 7 and 127 days, as well as an additional 215 variables which may be Cepheids or Population II pulsators. We used the Cepheid sample to test the absolute calibration of theoretical gri Period–Luminosity relations and found good agreement with the maser distance to this galaxy. The expected data products from the Large Synoptic Survey Telescope should enable Cepheid searches out to at least 10 Mpc.

First microwave generation in the FOM free-electron maser

NARCIS (Netherlands)

Verhoeven, A. G. A.; Bongers, W. A.; Bratman, V. L.; Caplan, M.; Denisov, G. G.; van der Geer, C. A. J.; Manintveld, P.; Poelman, A. J.; Pluygers, J.; Shmelyov, M. Y.; Smeets, P. H. M.; Sterk, A. B.; Urbanus, W. H.

1998-01-01

A free-electron maser (FEM) has been built as a pilot experiment for a millimetre-wave source for applications on future fusion research devices such as ITER, the International Tokamak Experimental Reactor. A unique feature of the Dutch fusion FEM is the possibility to tune the frequency over the

Correlation between SiO v = 3 J = 1 → 0 maser excitation and the light curve of a long-period variable star

Science.gov (United States)

Oyadomari, Miyako; Imai, Hiroshi; Nagayama, Takumi; Oyama, Tomoaki; Matsumoto, Naoko; Nakashima, Jun-ichi; Cho, Se-Hyung

2018-03-01

In order to understand the excitation mechanisms of silicon monoxide (SiO) masers around long-period variables (LPVs), we have investigated distributions of the SiO v = 2 and v = 3 J = 1 → 0 masers around 12 LPVs by very long baseline interferometry (VLBI) observations with the VLBI Exploration of Radio Astrometry (VERA) and the Nobeyama 45 m telescopes. VLBI fringes of the v = 3 maser emission were detected for five LPVs. The composite maps of the v = 2 and v = 3 masers were made for T Cep, W Hya, WX Psc, and R Leo using the spectral line phase-referencing technique. The v = 2 maser spots were distributed in a ring-like form around the central stars, while it is difficult to recognize any specific morphology in the v = 3 maser distributions due to the small number of v = 3 spots detected. However in T Cep, we find that the distribution of the v = 3 maser spots correlates well with the v = 2 masers within a few milliarcseconds (0.2-0.3 au) in position and 1 km s-1 in line-of-sight velocity at the light curve phase of ϕ = 0.28 (ϕ = 0.0 and 1.0 correspond to the visible light maxima). This correlation implies that the mechanism of line-overlapping between the mid-infrared lines of H2O and SiO molecules works in T Cep at ϕ = 0.28. We discuss the possibility that the line-overlapping may work at the limited duration from the maximum to the minimum of the stellar light curve.

Circadian clock, cell cycle and cancer

Directory of Open Access Journals (Sweden)

Cansu Özbayer

2011-12-01

Full Text Available There are a few rhythms of our daily lives that we are under the influence. One of them is characterized by predictable changes over a 24-hour timescale called circadian clock. This cellular clock is coordinated by the suprachiasmatic nucleus in the anterior hypothalamus. The clock consist of an autoregulatory transcription-translation feedback loop compose of four genes/proteins; BMAL1, Clock, Cyrptochrome, and Period. BMAL 1 and Clock are transcriptional factors and Period and Cyrptochrome are their targets. Period and Cyrptochrome dimerize in the cytoplasm to enter the nucleus where they inhibit Clock/BMAL activity.It has been demonstrate that circadian clock plays an important role cellular proliferation, DNA damage and repair mechanisms, checkpoints, apoptosis and cancer.

Cerenkov maser operation at lower-mm wavelengths

International Nuclear Information System (INIS)

Garate, E.; Cook, R.; Heim, P.; Layman, R.; Walsh, J.

1985-01-01

The basic operating principles of Cerenkov maser oscillators are briefly reviewed and the experimental performance of a 3-mm device is discussed. A power level of approximately 100 kW was achieved at 88 GHz and voltage tuning from 84 to 128 GHz on the fundamental TM 01 mode was observed. Operation on higher-order modes at frequencies up to 300--320 GHz was demonstrated, and a two-stage buncher-amplifier configuration was investigated

Polarisation observations of VY Canis Majoris H2O 5 32-441 620.701 GHz maser emission with HIFI

NARCIS (Netherlands)

Harwit, M.; Houde, M.; Sonnentrucker, P.; Boogert, A. C. A.; Cernicharo, J.; De Beck, E.; Decin, L.; Henkel, C.; Higgins, R. D.; Jellema, W.; Kraus, A.; McCoey, C.; Melnick, G. J.; Menten, K. M.; Risacher, C.; Teyssier, D.; Vaillancourt, J. E.; Alcolea, J.; Bujarrabal, V.; Dominik, C.; Justtanont, K.; de Koter, A.; Marston, A.P.; Olofsson, H.; Planesas, P.; Schmidt, M.; Schöier, F. L.; Szczerba, R.; Waters, L.B.F.M.

2010-01-01

Water vapour maser emission from evolved oxygen-rich stars remains poorly understood. Additional observations, including polarisation studies and simultaneous observation of different maser transitions may ultimately lead to greater insight. Aims. We have aimed to elucidate the nature and structure

Developments and studies on the (T)HMC processes in a final repository for heat generating radioactive wastes. Synthesis and final report; Entwicklungen und Untersuchungen zu (T)HMC-Prozessen eines Endlagers fuer Waerme entwickelnde radioaktive Abfaelle. Synthese und Abschlussbericht

Energy Technology Data Exchange (ETDEWEB)

Weyand, Torben [Bonn Univ. (Germany); Bracke, Guido; Fischer, Heidemarie; Frieling, Gerd; Hansmeier, Christina; Hotzel, Stephan; Kock, Ingo; Seher, Holger

2014-10-15

The report on developments and studies on the (T)HMC (thermal-hydraulic-mechanical-chemical) processes in a final repository for heat generating radioactive wastes covers the following topics: description of the projects, applied codes: TOUGH2, FLAC3D, TOUGH2 and FLAC3D, TOUHREACT/PetraSim, MARNIE, PHREEQC, geochemists workbench, SUSA; safety relevant singular processes in the transition phase, uncertainties due to process interactions, coupling of mass transport and geochemical equilibria, further developments and application of numerical simulations in the transition phase.

Controllable clock circuit design in PEM system

International Nuclear Information System (INIS)

Sun Yunhua; Wang Peihua; Hu Tingting; Feng Baotong; Shuai Lei; Huang Huan; Wei Shujun; Li Ke; Zhao Jingwei; Wei Long

2011-01-01

A high-precision synchronized clock circuit design will be presented, which can supply steady, reliable and anti-jamming clock signal for the data acquirement (DAQ) system of Positron Emission Mammography (PEM). This circuit design is based on the Single-Chip Microcomputer and high-precision clock chip, and can achieve multiple controllable clock signals. The jamming between the clock signals can be reduced greatly with the differential transmission. Meanwhile, the adoption of CAN bus control in the clock circuit can prompt the clock signals to be transmitted or masked simultaneously when needed. (authors)

Controllable clock circuit design in PEM system

International Nuclear Information System (INIS)

Sun Yunhua; Wang Peilin; Hu Tingting; Feng Baotong; Shuai Lei; Huang Huan; Wei Shujun; Li Ke; Zhao Jingwei; Wei Long

2010-01-01

A high-precision synchronized clock circuit design will be presented, which can supply steady, reliable and anti-jamming clock signal for the data acquirement (DAQ) system of Positron Emission Mammography (PEM). This circuit design is based on the Single-Chip Microcomputer and high-precision clock chip, and can achieve multiple controllable clock signals. The jamming between the clock signals can be reduced greatly with the differential transmission. Meanwhile, the adoption of CAN bus control in the clock circuit can prompt the clock signals to be transmitted or masked simultaneously when needed. (authors)

OBSERVATIONAL STUDY OF THE CONTINUUM AND WATER MASER EMISSION IN THE IRAS 19217+1651 REGION

Energy Technology Data Exchange (ETDEWEB)

Rodriguez-Esnard, T.; Trinidad, M. A. [Departamento de Astronomia, Universidad de Guanajuato, Apdo Postal 144, Guanajuato, GTO, Mexico CP 36000 (Mexico); Migenes, V., E-mail: tatiana@iga.cu, E-mail: trinidad@astro.ugto.mx, E-mail: vmigenes@byu.edu [Department of Physics and Astronomy, Brigham Young University, ESC-N145, Provo, UT 84602 (United States)

2012-12-20

We report interferometric observations of the high-mass star-forming region IRAS 19217+1651. We observed the radio continuum (1.3 cm and 3.6 cm) and water maser emission using the Very Large Array (VLA-EVLA) in transition mode (configuration A). Two radio continuum sources were detected at both wavelengths, I19217-A and I19217-B. In addition, 17 maser spots were observed distributed mainly in two groups, M1 and M2, and one isolated maser. This latter could be indicating the relative position of another continuum source which we did not detect. The results indicate that I19217-A appears to be consistent with an ultracompact H II region associated with a zero-age main-sequence B0-type star. Furthermore, the 1.3 cm continuum emission of this source suggests a cometary morphology. In addition, I19217-B appears to be an H II region consisting of at least two stars, which may be contributing to its complex structure. It was also found that the H{sub 2}O masers of the group M1 are apparently associated with the continuum source I19217-A. These are tracing motions which are not gravitationally bound according to their spatial distribution and kinematics. They also seem to be describing outflows in the direction of the elongated cometary region. On the other hand, the second maser group, M2, could be tracing the base of a jet. Finally, infrared data from Spitzer, Midcourse Space Experiment, and IRIS show that IRAS 19217+1651 is embedded inside a large open bubble, like a broken ring, which possibly has affected the morphology of the cometary H II region observed at 1.3 cm.

A NEW RADIO RECOMBINATION LINE MASER OBJECT TOWARD THE MonR2 H II REGION

Energy Technology Data Exchange (ETDEWEB)

Jimenez-Serra, I.; Zhang, Q.; Dierickx, M.; Patel, N. [Harvard-Smithsonian Center for Astrophysics, 60 Garden Street, Cambridge, MA 02138 (United States); Baez-Rubio, A.; Rivilla, V. M.; Martin-Pintado, J., E-mail: ijimenez-serra@cfa.harvard.edu, E-mail: qzhang@cfa.harvard.edu, E-mail: mdierickx@cfa.harvard.edu, E-mail: npatel@cfa.harvard.edu, E-mail: ryvendel@gmail.com, E-mail: jmartin@cab.inta-csic.es, E-mail: baezra@cab.inta-csic.es [Centro de Astrobiologia (CSIC/INTA), Ctra. de Torrejon a Ajalvir km 4, E-28850 Torrejon de Ardoz, Madrid (Spain)

2013-02-10

We report the detection of a new radio recombination line (RRL) maser object toward the IRS2 source in the MonR2 ultracompact H II region. The continuum emission at 1.3 mm and 0.85 mm and the H30{alpha} and H26{alpha} lines were observed with the Submillimeter Array (SMA) at angular resolutions of {approx}0.''5-3''. The SMA observations show that the MonR2-IRS2 source is very compact and remains unresolved at spatial scales {<=}400 AU. Its continuum power spectrum at millimeter wavelengths is almost flat ({alpha} = -0.16, with S{sub {nu}}{proportional_to}{nu}{sup {alpha}}), indicating that this source is dominated by optically thin free-free emission. The H30{alpha} and H26{alpha} RRL emission is also compact and peaks toward the position of the MonR2-IRS2 source. The measured RRL profiles are double peaked with the H26{alpha} line showing a clear asymmetry in its spectrum. Since the derived line-to-continuum flux ratios ({approx}80 and 180 km s{sup -1} for H30{alpha} and H26{alpha}, respectively) exceed the LTE predictions, the RRLs toward MonR2-IRS2 are affected by maser amplification. The amplification factors are, however, smaller than those found toward the emission-line star MWC349A, indicating that MonR2-IRS2 is a weakly amplified maser. Radiative transfer modeling of the RRL emission toward this source shows that the RRL masers arise from a dense and collimated jet embedded in a cylindrical ionized wind, oriented nearly along the direction of the line of sight. High-angular resolution observations at submillimeter wavelengths are needed to unveil weakly amplified RRL masers in very young massive stars.

GPS Composite Clock Analysis

OpenAIRE

Wright, James R.

2008-01-01

The GPS composite clock defines GPS time, the timescale used today in GPS operations. GPS time is illuminated by examination of its role in the complete estimation and control problem relative to UTC/TAI. The phase of each GPS clock is unobservable from GPS pseudorange measurements, and the mean phase of the GPS clock ensemble (GPS time) is unobservable. A new and useful observability definition is presented, together with new observability theorems, to demonstrate explicitly that GPS time is...

Automatic control of clock duty cycle

Science.gov (United States)

Feng, Xiaoxin (Inventor); Roper, Weston (Inventor); Seefeldt, James D. (Inventor)

2010-01-01

In general, this disclosure is directed to a duty cycle correction (DCC) circuit that adjusts a falling edge of a clock signal to achieve a desired duty cycle. In some examples, the DCC circuit may generate a pulse in response to a falling edge of an input clock signal, delay the pulse based on a control voltage, adjust the falling edge of the input clock signal based on the delayed pulse to produce an output clock signal, and adjust the control voltage based on the difference between a duty cycle of the output clock signal and a desired duty cycle. Since the DCC circuit adjusts the falling edge of the clock cycle to achieve a desired duty cycle, the DCC may be incorporated into existing PLL control loops that adjust the rising edge of a clock signal without interfering with the operation of such PLL control loops.

Registration of H2O and SiO masers in the Calabash Nebula to confirm the planetary nebula paradigm

Science.gov (United States)

Dodson, R.; Rioja, M.; Bujarrabal, V.; Kim, J.; Cho, S. H.; Choi, Y. K.; Youngjoo, Y.

2018-05-01

We report on the astrometric registration of very long baseline interferometry images of the SiO and H2O masers in OH 231.8+4.2, the iconic proto-planetary nebula also known as the Calabash nebula, using the Korean VLBI Network and source frequency phase referencing. This, for the first time, robustly confirms the alignment of the SiO masers, close to the asymptotic giant branch star, driving the bilobe structure with the water masers in the outflow. We are able to trace the bulk motions for the H2O masers over the last few decades to be 19 km s-1 and deduce that the age of this expansion stage is 38 ± 2 yr. The combination of this result with the distance allows a full 3D reconstruction and confirms that the H2O masers lie on and expand along the known large-scale symmetry axis and that the outflow is only a few decades old, so mass loss is almost certainly ongoing. Therefore, we conclude that the SiO emission marks the stellar core of the nebular, the H2O emission traces the expansion, and there must be multiple epochs of ejection to drive the macro-scale structure.

Generation of microwaves by a slow wave electron cyclotron maser with axial injection

International Nuclear Information System (INIS)

Michie, R.B.; Vomvoridis, J.

1984-01-01

Experimental measurements of microwave generation by a new electron beam wave interaction is presented. This slow wave electron cyclotron maser (ECM) has a continuous electron beam injected axially into a slow wave structure containing a circularly polarized HE, hybrid electric (HE) mode. A longitudinal magnetic field produces microwaves by maser action. The slow wave structure allows energy to be coupled out of an electron beam with no initial transverse momentum. This is similar to klystrons, traveling wave tubes, and Cherenkov masers, but there is no axial beam bunching. Therefore, ECM designs using relativistic electron beams are allowed. This ECM is similar to a gyrotron in that the electrons are coupled through their cyclotron motion to the wave, but there is no need for initial electron velocity perpendicular to the background magnetic field. Therefore, a narrower spread of electron beam energy about the ECM resonance is possible which gives higher theoretical efficiency. A nonlinear analysis of energy coupling of electrons to the slow wave in the ECM and the design of the slow wave ECM microwave amplifier at 10 GHz using a 200 KeV axial electron beam in 3 KG magnetic field is included

CORRELATION OF SUPERNOVA REMNANT MASERS AND GAMMA-RAY SOURCES

International Nuclear Information System (INIS)

Hewitt, John W.; Yusef-Zadeh, Farhad; Wardle, Mark

2009-01-01

Supernova remnants (SNRs) interacting with molecular clouds are potentially exciting systems in which to detect evidence of cosmic ray acceleration. Prominent γ-ray emission is produced via the decay of neutral pions when cosmic rays encounter nearby dense clouds. In many of the SNRs coincident with γ-ray sources, the presence of OH (1720 MHz) masers is used to identify interaction with dense gas and to provide a kinematic distance to the system. In this Letter we use statistical tests to demonstrate that there is a correlation between these masers and a class of GeV- to TeV-energy γ-ray sources coincident with interacting remnants. For pion decay the γ-ray luminosity provides a direct estimate of the local cosmic ray density. We find the cosmic ray density is enhanced by one to two orders of magnitude over the local solar value, comparable to X-ray-induced ionization in these remnants. The inferred ionization rates are sufficient to explain non-equilibrium chemistry in the post-shock gas, where high columns of hydroxyl are observed.

Atomic and gravitational clocks

International Nuclear Information System (INIS)

Canuto, V.M.; City Coll., New York; Goldman, I.

1982-01-01

Atomic and gravitational clocks are governed by the laws of electrodynamics and gravity respectively. While the strong equivalence principle (SEP) assumes that the two clocks have been synchronous at all times, recent planetary data seem to suggest a possible violation of the SEP. Past analysis of the implications of an SEP violation on different physical phenomena revealed no disagreement. However, these studies assumed that the two different clocks can be consistently constructed within the framework. The concept of scale invariance, and the physical meaning of different systems of units, are now reviewed and the construction of two clocks that do not remain synchronous-whose rates are related by a non-constant function βsub(a)-is demonstrated. The cosmological character of βsub(a) is also discussed. (author)

Egyptian "Star Clocks"

Science.gov (United States)

Symons, Sarah

Diagonal, transit, and Ramesside star clocks are tables of astronomical information occasionally found in ancient Egyptian temples, tombs, and papyri. The tables represent the motions of selected stars (decans and hour stars) throughout the Egyptian civil year. Analysis of star clocks leads to greater understanding of ancient Egyptian constellations, ritual astronomical activities, observational practices, and pharaonic chronology.

Operation of a quasioptical electron cyclotron maser

International Nuclear Information System (INIS)

Morse, E.C.; Pyle, R.V.

1984-12-01

The electron cyclotron maser or gyrotron concept has been developed to produce sources producing 200 kW at 28 GHz continuously, and higher power outputs and frequencies in pulsed mode. These sources have been useful in electron cyclotron resonance heating (ECRH) in magnetically confined fusion devices. However, higher frequencies and higher power levels will be required in reactor-grade fusion plasmas, with likely requirements of 1.0 MW or more per source at 140 GHz. Conventional gyrotrons follow a trend of decreasing power for increasing frequency. In order to circumvent this problem, the quasioptical electron cyclotron maser was proposed. In this device, the closed resonator of the conventional gyrotron is replaced with an open, Fabry-Perot type resonator. The cavity modes are then the TEM-type modes of an optical laser. The advantage of this configuration is that the cavity size is not a function of frequency, since the length can be any half-integer number of wavelengths. Furthermore, the beam traverses across the cavity transverse to the direction of radiation output, and thus the rf window design is less complicated than in conventional tubes. The rf output, if obtained by diffraction coupling around one of the mirrors, could be in a TEM mode, which would allow for quasioptical transmission of the microwaves into the plasma in fusion devices. 4 references, 1 figure

Superconducting magnet for a Ku-band maser.

Science.gov (United States)

Berwin, R.; Wiebe, E.; Dachel, P.

1972-01-01

A superconducting magnet to provide a uniform magnetic field of up to 8000 G in a 1.14-cm gap for the 15.3-GHz (Ku-band) traveling wave maser is described. The magnet operates in a persistent mode in the vacuum environment of a closed-cycle helium refrigerator (4.5 K). The features of a superconducting switch, which has both leads connected to 4.5 K heat stations and thereby does not receive heat generated by the magnet charging leads, are described.

Polarisation observations of VY Canis Majoris H2O 5(32)-4(41) 620.701 GHz maser emission with HIFI

NARCIS (Netherlands)

Harwit, M.; Houde, M.; Sonnentrucker, P.; Boogert, A. C. A.; Cernicharo, J.; de Beck, E.; Decin, L.; Henkel, C.; Higgins, R. D.; Jellema, W.; Kraus, A.; McCoey, C.; Melnick, G. J.; Menten, K. M.; Risacher, C.; Teyssier, D.; Vaillancourt, J. E.; Alcolea, J.; Bujarrabal, V.; Dominik, C.; Justtanont, K.; de Koter, A.; Marston, A. P.; Olofsson, H.; Planesas, P.; Schmidt, M.; Schöier, F. L.; Szczerba, R.; Waters, L. B. F. M.

2010-01-01

Context. Water vapour maser emission from evolved oxygen-rich stars remains poorly understood. Additional observations, including polarisation studies and simultaneous observation of different maser transitions may ultimately lead to greater insight. Aims. We have aimed to elucidate the nature and

A VMEbus clock system for accelerator control

International Nuclear Information System (INIS)

Beechy, D.G.; McClure, C.R.

1992-01-01

Because an accelerator has many systems which must operate with a high degree of synchronization, a clock signal is typically generated which carries timing information to the various accelerator components. This paper discusses two VMEbus modules designed to generate and receive this clock signal. Together they implement a clock system which can generate timing markers with 200 nanosecond resolution and can generate timing delays of over one hour with one microsecond resolution. The Clock Generator module contains both a time line generator programmed to produce clock events at specific times and eight programmable input channels to produce clock events when externally triggered. Additional clock events are generated directly from the VMEbus. Generators can be cascaded for added capability. The Clock Timer module receives the signal from the generator. It can be programmed to recognize specific clock events which act as triggers to the eight timing channels on the module. Each timing channel is programmed with a 32-bit delay value. The channels are clocked at 1 MHz. At the end of the delay period, a timer channel produces an output pulse and optionally can generate a bus interrupt

Rotation-Infall Motion around the Protostar IRAS 16293-2422 Traced by Water Maser Emission

Science.gov (United States)

Imai, Hiroshi; Iwata, Takahiro; Miyoshi, Makoto

1999-08-01

We made VLBI observations of the water maser emission associated with a protostar, IRAS 16293-2422, using the Kashima-Nobeyama Interferometer (KNIFE) and the Japanese domestic VLBI network (J-Net).\\footnote[2]. These distributions of water maser features showed the blue-shifted and red-shifted components separated in the north-south direction among three epochs spanning three years. The direction of the separation was perpendicular to the molecular outflow and parallel to the elongation of the molecular disk. These steady distributions were successfully modeled by a rotating-infalling disk with an outer radius of 100 AU around a central object with a mass of 0.3 MO . The local specific angular momentum of the disk was calculated to be 0.2-1.0times 10-3 km s-1 pc at a radius of 20-100 AU. This value is roughly equal to that of the disk of IRAS 00338+6312 in L1287 and those of the molecular disks around the protostars in the Taurus molecular cloud. The relatively large disk radius of about 100 AU traced by water maser emission suggests that impinging clumps onto the disk should be hotter than 200 K to excite the water maser emission. Mizusawa, Nobeyama, and Kagoshima stations are operated by staff members of National Astronomical Observatory of the Ministry of Education, Science, Sports and Culture. Kashima station is operated by staff members of Communications Research Laboratory of the Ministry of Posts and Telecomunications. The recent status of J-Net is seen in the WWW home page: http://www.nro.nao.ac.jp/\\ \\ miyaji/Jnet.

An analysis of clock-shift experiments: is scatter increased and deflection reduced in clock-shifted homing pigeons?

Science.gov (United States)

Chappell

1997-01-01

Clock-shifting (altering the phase of the internal clock) in homing pigeons leads to a deflection in the vanishing bearing of the clock-shifted group relative to controls. However, two unexplained phenomena are common in clock-shift experiments: the vanishing bearings of the clock-shifted group are often more scattered (with a shorter vector length) than those of the control group, and the deflection of the mean bearing of the clock-shifted group from that of the controls is often smaller than expected theoretically. Here, an analysis of 55 clock-shift experiments performed in four countries over 21 years is reported. The bearings of the clock-shifted groups were significantly more scattered than those of controls and less deflected than expected, but these effects were not significantly different at familiar and unfamiliar sites. The possible causes of the effects are discussed and evaluated with reference to this analysis and other experiments. The most likely causes appear to be conflict between the directions indicated by the sun compass and either unshifted familiar visual landmarks (at familiar sites only) or the unshifted magnetic compass (possible at both familiar and unfamiliar sites).

Molecular cogs of the insect circadian clock.

Science.gov (United States)

Shirasu, Naoto; Shimohigashi, Yasuyuki; Tominaga, Yoshiya; Shimohigashi, Miki

2003-08-01

During the last five years, enormous progress has been made in understanding the molecular basis of circadian systems, mainly by molecular genetic studies using the mouse and fly. Extensive evidence has revealed that the core clock machinery involves "clock genes" and "clock proteins" functioning as molecular cogs. These participate in transcriptional/translational feedback loops and many homologous clock-components in the fruit fly Drosophila are also expressed in mammalian clock tissues with circadian rhythms. Thus, the mechanisms of the central clock seem to be conserved across animal kingdom. However, some recent studies imply that the present widely accepted molecular models of circadian clocks may not always be supported by the experimental evidence.

High Performance Clocks and Gravity Field Determination

Science.gov (United States)

Müller, J.; Dirkx, D.; Kopeikin, S. M.; Lion, G.; Panet, I.; Petit, G.; Visser, P. N. A. M.

2018-02-01

Time measured by an ideal clock crucially depends on the gravitational potential and velocity of the clock according to general relativity. Technological advances in manufacturing high-precision atomic clocks have rapidly improved their accuracy and stability over the last decade that approached the level of 10^{-18}. This notable achievement along with the direct sensitivity of clocks to the strength of the gravitational field make them practically important for various geodetic applications that are addressed in the present paper. Based on a fully relativistic description of the background gravitational physics, we discuss the impact of those highly-precise clocks on the realization of reference frames and time scales used in geodesy. We discuss the current definitions of basic geodetic concepts and come to the conclusion that the advances in clocks and other metrological technologies will soon require the re-definition of time scales or, at least, clarification to ensure their continuity and consistent use in practice. The relative frequency shift between two clocks is directly related to the difference in the values of the gravity potential at the points of clock's localization. According to general relativity the relative accuracy of clocks in 10^{-18} is equivalent to measuring the gravitational red shift effect between two clocks with the height difference amounting to 1 cm. This makes the clocks an indispensable tool in high-precision geodesy in addition to laser ranging and space geodetic techniques. We show how clock measurements can provide geopotential numbers for the realization of gravity-field-related height systems and can resolve discrepancies in classically-determined height systems as well as between national height systems. Another application of clocks is the direct use of observed potential differences for the improved recovery of regional gravity field solutions. Finally, clock measurements for space-borne gravimetry are analyzed along with

Stokes polarimetry of main-line OH emission from stellar masers

International Nuclear Information System (INIS)

Claussen, M.J.; Fix, J.D.

1982-01-01

Main-line OH emission has been measured in all four Stokes parameters from seven late-type variable stars and the F8 supergiant IRC+10420. Linearly polarized features were detected in UX Cyg, U Ori, and IRC+10420 at 1665 MHz. The linearly polarized features in UX Cyg and IRC +10420, when combined with adjacent circularly polarized features suggest Zeeman patterns. A polarization pattern in IRC+10420 is probably the best example of a complete Zeeman pattern yet observed in stellar masers, although it appears to lack the shifted linear (sigma) components. This study, combined with other recent work, shows that linearly polarized features in stellar sources are uncommon. Only about 10% of the stellar OH sources show linearly polarized features. As an aid in accounting for the observed polarization properties of stellar OH masers, model mass flows were calculated using magnetic field structures similar to that of the solar wind. Conclusions drawn from this model were: (1) unpolarized or weakly circularly polarized emission from sources can arise from the entire circumstellar shell; (2) circular polarization without linear polarization can be produced either by emission from the entire shell or by enhanced OH densities in small regions of the shell provided there are sufficient free electrons present to depolarize the linear components; and (3) Zeeman patterns which include both circular and linear polarizations can be produced in OH density enhancements if electron densities are low. The electron densities required for effective Faraday depolarization yield emission measures of the order of 10 9 pc cm -6 . Given the large distances of stellar OH masers, the thermal continuum emission from such depolarizing electrons would probably be undetectable

The importance of plasma effects on electron-cyclotron maser-emission from flaring loops

Science.gov (United States)

Sharma, R. R.; Vlahos, L.; Papadopoulos, K.

1982-01-01

Electron cyclotron maser instability has been suggested as the cause of the observed short (10-20 msec), intense (an approximate brightness temperature of 10 to the 15th K) and up to 100% polarized microwave solar emission. It is shown that plasma effects and thermal cyclotron damping, ignored in previous theories, play an important role in controlling the frequency range of the emission. The radio emission is suppressed for ratios of the plasma frequency to the cyclotron frequency smaller than 0.4. An examination of the cyclotron damping, reveals that the maser action is suppressed unless a large fraction (i.e., over 10%) of the accelerated electrons participates in the emission process.

JY1 time scale: a new Kalman-filter time scale designed at NIST

International Nuclear Information System (INIS)

Yao, Jian; Parker, Thomas E; Levine, Judah

2017-01-01

We report on a new Kalman-filter hydrogen-maser time scale (i.e. JY1 time scale) designed at the National Institute of Standards and Technology (NIST). The JY1 time scale is composed of a few hydrogen masers and a commercial Cs clock. The Cs clock is used as a reference clock to ease operations with existing data. Unlike other time scales, the JY1 time scale uses three basic time-scale equations, instead of only one equation. Also, this time scale can detect a clock error (i.e. time error, frequency error, or frequency drift error) automatically. These features make the JY1 time scale stiff and less likely to be affected by an abnormal clock. Tests show that the JY1 time scale deviates from the UTC by less than  ±5 ns for ∼100 d, when the time scale is initially aligned to the UTC and then is completely free running. Once the time scale is steered to a Cs fountain, it can maintain the time with little error even if the Cs fountain stops working for tens of days. This can be helpful when we do not have a continuously operated fountain or when the continuously operated fountain accidentally stops, or when optical clocks run occasionally. (paper)

Atomic clocks for geodesy

Science.gov (United States)

Mehlstäubler, Tanja E.; Grosche, Gesine; Lisdat, Christian; Schmidt, Piet O.; Denker, Heiner

2018-06-01

We review experimental progress on optical atomic clocks and frequency transfer, and consider the prospects of using these technologies for geodetic measurements. Today, optical atomic frequency standards have reached relative frequency inaccuracies below 10‑17, opening new fields of fundamental and applied research. The dependence of atomic frequencies on the gravitational potential makes atomic clocks ideal candidates for the search for deviations in the predictions of Einstein’s general relativity, tests of modern unifying theories and the development of new gravity field sensors. In this review, we introduce the concepts of optical atomic clocks and present the status of international clock development and comparison. Besides further improvement in stability and accuracy of today’s best clocks, a large effort is put into increasing the reliability and technological readiness for applications outside of specialized laboratories with compact, portable devices. With relative frequency uncertainties of 10‑18, comparisons of optical frequency standards are foreseen to contribute together with satellite and terrestrial data to the precise determination of fundamental height reference systems in geodesy with a resolution at the cm-level. The long-term stability of atomic standards will deliver excellent long-term height references for geodetic measurements and for the modelling and understanding of our Earth.

Design and analysis of optically pumped submillimeter waveguide maser amplifiers and oscillators

Science.gov (United States)

Galantowicz, T. A.

1975-01-01

The design and experimental measurements are described of an optically pumped far-infrared (FIR) waveguide maser; preliminary measurements on a FIR waveguide amplifier are presented. The FIR maser was found to operate satisfactorily in a chopped CW mode using either methanol (CH3OH) or acetonitrile (CH3CN) as the active molecule. Two other gases, difluoroethane and difluoroethylene, produced an unstable output with high threshold and low output power when operated in the chopped CW mode. Experimental measurements include FIR output versus cavity length, output beam pattern, output power versus pressure, and input power. The FIR output was the input to an amplifier which was constructed similar to the oscillator. An increase of 10% in output power was noted on the 118.8 microns line of methanol.

Circadian rhythms and light responsiveness of mammalian clock gene, Clock and BMAL1, transcripts in the rat retina.

Science.gov (United States)

Namihira, M; Honma, S; Abe, H; Tanahashi, Y; Ikeda, M; Honma, K

1999-08-13

Circadian expression and light-responsiveness of the mammalian clock genes, Clock and BMAL1, in the rat retina were examined by in situ hydbribization under constant darkness. A small but significant daily variation was detected in the Clock transcript level, but not in BMAL1. Light increased the Clock and BMAL1 expressions significantly when examined 60 min after exposure. The light-induced gene expression was phase-dependent for Clock and peaked at ZT2, while rather constant throughout the day for BMAL1. These findings suggest that Clock and BMAL1 play different roles in the generation of circadian rhytm in the retina from those in the suprachiasmatic nucleus. Different roles are also suggested between the two genes in the photic signal transduction in the retina.

First mm-wave generation in the FOM free electron maser

NARCIS (Netherlands)

Verhoeven, A. G. A.; Bongers, W. A.; Bratman, V. L.; Caplan, M.; Denisov, G. G.; van der Geer, C. A. J.; Manintveld, P.; Poelman, A. J.; Plomp, J.; Savilov, A. V.; Smeets, P. H. M.; Sterk, A. B.; Urbanus, W. H.

1999-01-01

A free electron maser (FEM) has been built as a pilot mm-wave source for applications on future fusion research devices such as international tokamak experimental reactor (ITER), A unique feature of the Dutch FEM is the possibility to tune the frequency over the entire range from 130 to 260 GHz at

Light and the human circadian clock

NARCIS (Netherlands)

Roenneberg, Till; Kantermann, Thomas; Juda, Myriam; Vetter, Céline; Allebrandt, Karla V

2013-01-01

The circadian clock can only reliably fulfil its function if it is stably entrained. Most clocks use the light-dark cycle as environmental signal (zeitgeber) for this active synchronisation. How we think about clock function and entrainment has been strongly influenced by the early concepts of the

A network of (autonomic) clock outputs

NARCIS (Netherlands)

Kalsbeek, A.; Perreau-Lenz, S.; Buijs, R. M.

2006-01-01

The circadian clock in the suprachiasmatic nuclei (SCN) is composed of thousands of oscillator neurons, each dependent on the cell-autonomous action of a defined set of circadian clock genes. A major question is still how these individual oscillators are organized into a biological clock that

FROM STABLE LASERS TO OPTICAL-FREQUENCY CLOCKS:. Merging the UltraFast and the UltraStable, for a New Epoch of Optical Frequency Measurements, Standards, & Applications

Science.gov (United States)

Hall, J. L.; Ye, J.; Ma, L.-S.; Peng, J.-L.; Notcutt, M.; Jost, J. D.; Marian, A.

2002-04-01

This is a report on behalf of the World Team of Stable Laser and Optical Frequency Measurement Enthusiasts, even if most detailed illustrations draw mainly from our work at JILA. Specifically we trace some of the key ideas that have led from the first stabilized lasers, to frequency measurement up to 88 THz using frequency chains, revision of the Definition of the Metre, extension of coherent frequency chain technology into the visible, development of a vast array of stabilized lasers, and finally the recent explosive growth of direct frequency measurement capability in the visible using fs comb techniques. We present our recent work showing a Molecular Iodine-based Optical Clock which delivers, over a range of time scales, rf output at a stability level basically equivalent to the RF stability prototype, the Hydrogen Maser. We note the bifurcation between single-ion-based clocks - likely to be the stability/reproducibility ultimate winners in the next generation - and simpler systems based on gas cells, which can have impressive stabilities but may suffer from a variety of reproducibility-limiting processes. Active Phase-Lock synchronization of independent fs lasers allows sub-fs timing control. Copies of related works in our labs may be found/obtained at our website .

Towards Self-Clocked Gated OCDMA Receiver

Science.gov (United States)

Idris, S.; Osadola, T.; Glesk, I.

2013-02-01

A novel incoherent OCDMA receiver with incorporated all-optical clock recovery for self-synchronization of a time gate for the multi access interferences (MAI) suppression and minimizing the effect of data time jitter in incoherent OCDMA system was successfully developed and demonstrated. The solution was implemented and tested in a multiuser environment in an out of the laboratory OCDMA testbed with two-dimensional wavelength-hopping time-spreading coding scheme and OC-48 (2.5 Gbp/s) data rate. The self-clocked all-optical time gate uses SOA-based fibre ring laser optical clock, recovered all-optically from the received OCDMA traffic to control its switching window for cleaning the autocorrelation peak from the surrounding MAI. A wider eye opening was achieved when the all-optically recovered clock from received data was used for synchronization if compared to a static approach with the RF clock being generated by a RF synthesizer. Clean eye diagram was also achieved when recovered clock is used to drive time gating.

Could Atomic clocks be affected by neutrinos?

CERN Document Server

Hanafi, Hanaa

2016-01-01

An atomic clock is a clock device that uses an electronic transition frequency of the electromagnetic spectrum of atoms as a frequency standard in order to derive a time standard since time is the reciprocal of frequency. If the electronic transition frequencies are in an "optical region", we are talking in this case about optical atomic clocks. If they are in an "microwave region" these atomic clocks are made of the metallic element cesium so they are called Cesium atomic clocks. Atomic clocks are the most accurate time and frequency standards known despite the different perturbations that can affect them, a lot of researches were made in this domain to show how the transitions can be different for different type of perturbations..Since atomic clocks are very sensitive devices, based on coherent states (A coherent state tends to loose coherence after interacting). One question can arise (from a lot of questions) which is why cosmic neutrinos are not affecting these clocks? The answer to this question requir...

A network of (autonomic) clock outputs

NARCIS (Netherlands)

Kalsbeek, A.; Perreau-Lenz, S.; Buijs, R. M.

2006-01-01

The circadian clock in the suprachiasmatic nuclei (SCN) is composed of thousands of oscillator neurons, each of which is dependent on the cell-autonomous action of a defined set of circadian clock genes. A major question is still how these individual oscillators are organized into a biological clock

Biological Clocks & Circadian Rhythms

Science.gov (United States)

Robertson, Laura; Jones, M. Gail

2009-01-01

The study of biological clocks and circadian rhythms is an excellent way to address the inquiry strand in the National Science Education Standards (NSES) (NRC 1996). Students can study these everyday phenomena by designing experiments, gathering and analyzing data, and generating new experiments. As students explore biological clocks and circadian…

Interpretation of the H2O maser outbursts in Orion

International Nuclear Information System (INIS)

Strel'nitskij, V.S.

1982-01-01

It is shown, that the H 2 O maser that flared up in Orion (+8 km/s) was partly unsaturated. The anti-correlation between the line width and intensity, the asymmetry of the profile and the changes of the visibility function within it are explained by blending of two componenets, one of which has experienced a flare. From the observed polarization properties the upper limit to the electron density (nsub(e) 5 cm -3 ), the strength of the magnetic field (B approximately 10 -2 G) and its direction (position angle phi approximately -15 deg) within the source are deduced. According to the proposed physical model the source is a gas condensation, pressed, heated and accelerated by the strong stellar wind from a young star (possibly IRc4). The maser is pumped by the CCr-process at sup(n)H approximately 10 11 -10 12 cm -3 . If the condensation is a remnant of a circumstellar gas-dust disk, the magnetic field within the disk must be essentially azimuthal [ru

Electron cyclotron maser instability in the solar corona: The role of superthermal tails

International Nuclear Information System (INIS)

Vlahos, L.; Sharma, R.R.

1985-01-01

The effect of a superthermal component of electrons on the loss-cone--driven electron cyclotron maser instability is analyzed. We found that for a supertheral tail with temperature approx.10 keV (i) the first harmonic (X- and O-mode) is suppressed for n/sub t//n/sub r/roughly-equal1 (n/sub t/ and n/sub r/ are the densities of superthermal tail and loss-cone electrons) and (ii) the second harmonic (X- and O-modes) is suppressed for n/sub t//n/sub r/ -1 . We present a qualitative discussion on the formation of superthermal taisl and suggest that superthermal tails play an important role on the observed or available power, at microwave frequencies, from the electron cyclotron maser instability in the solar corona

Electron cyclotron maser instability in the solar corona - The role of superthermal tails

Science.gov (United States)

Vlahos, L.; Sharma, R. R.

1985-01-01

The effect of a superthermal component of electrons on the loss-cone-driven electron cyclotron maser instability is analyzed. It is found that for a superthermal tail with temperature about 10 KeV, the first harmonic (X- and O-mode) is suppressed for n(t)/n(r) of about 1 (n/t/ and n/r/ are the densities of superthermal tail and loss-cone electrons) and the second harmonic (X- and O-modes) is suppressed for n(t)/n(r) less than about 0.1. A qualitative discussion on the formation of superthermal tails is presented and it is suggested that superthermal tails play an important role on the observed or available power, at microwave frequencies, from the electron cyclotron maser instability in the solar corona.

Preliminary experiments on a planar electron beam for an intense free electron maser

International Nuclear Information System (INIS)

Kato, Katsumasa; Iwata, Kazuma; Kitamura, Taro; Yamada, Naohisa; Soga, Yukihiro; Kamada, Keiichi; Yoshida, Mitsuhiro; Ginzburg, Naum S.

2013-01-01

A planar wiggler magnetic field was used to increase the output power of an intense free electron maser. As a preliminary experiment, a cylindrical electron beam was injected into a planar wiggler field with an axial magnetic field. Without the axial magnetic field, the cylindrical beam could not propagate through the wiggler field with length of 1 m. The microwave with frequency of 40 GHz was observed only when the beam propagates through the wiggler field. The frequency was nearly equal to the expected frequency of the free electron maser interaction. Though a sheet electron beam with nearly the same energy propagated through the planar wiggler field with deformation of its cross section, the microwave with frequency of 40 GHz was not observed. (author)

Circadian clocks, epigenetics, and cancer

KAUST Repository

Masri, Selma; Kinouchi, Kenichiro; Sassone-Corsi, Paolo

2015-01-01

The interplay between circadian rhythm and cancer has been suggested for more than a decade based on the observations that shift work and cancer incidence are linked. Accumulating evidence implicates the circadian clock in cancer survival and proliferation pathways. At the molecular level, multiple control mechanisms have been proposed to link circadian transcription and cell-cycle control to tumorigenesis.The circadian gating of the cell cycle and subsequent control of cell proliferation is an area of active investigation. Moreover, the circadian clock is a transcriptional system that is intricately regulated at the epigenetic level. Interestingly, the epigenetic landscape at the level of histone modifications, DNA methylation, and small regulatory RNAs are differentially controlled in cancer cells. This concept raises the possibility that epigenetic control is a common thread linking the clock with cancer, though little scientific evidence is known to date.This review focuses on the link between circadian clock and cancer, and speculates on the possible connections at the epigenetic level that could further link the circadian clock to tumor initiation or progression.

First mm-VLBI Observations between the TRAO 14-m and the NRO 45-m Telescopes: Observations of 86 GHz SiO Masers in VY Canis Majoris

Science.gov (United States)

Shibata, Katsunori M.; Chung, Hyung-Soo; Kameno, Seiji; Roh, Duk-Gyoo; Umemoto, Tomofumi; Kim, Kwang-Dong; Asada, Keiichi; Han, Seog-Tae; Mochizuki, Nanako; Cho, Se-Hyung; Sawada-Satoh, Satoko; Kim, Hyun-Goo; Bushimata, Takeshi; Minh, Young Chol; Miyaji, Takeshi; Kuno, Nario; Mikoshiba, Hiroshi; Sunada, Kazuyoshi; Inoue, Makoto; Kobayashi, Hideyuki

2004-06-01

We have made VLBI observations at 86GHz using a 1000-km baseline between Korea and Japan with successful detections of SiO v = 1, J = 2 - 1 maser emissions from VY CMa and Orion KL in 2001 June. This was the first VLBI result for this baseline and the first astronomical VLBI observation for the Korean telescope. Since then, we observed SiO v = 1, J = 2 - 1 maser emission in VY CMa in 2002 January and 2003 February and derived the distributions of the maser emissions. Our results show that the maser emissions extend over 2-4 stellar radii, and were within the inner radius of the dust shell. We observed other SiO maser sources and continuum sources, and 86-GHz continuum emissions were detected from three continuum sources. It was verified that this baseline has a performance comparable to the most sensitive baseline in the VLBA and the CMVA, and is capable of investigating the proper motions of maser features in circumstellar envelopes using monitoring observations.

THE ZEEMAN EFFECT IN THE 44 GHZ CLASS I METHANOL MASER LINE TOWARD DR21(OH)

Energy Technology Data Exchange (ETDEWEB)

Momjian, E. [National Radio Astronomy Observatory, P.O. Box O, Socorro, NM 87801 (United States); Sarma, A. P., E-mail: emomjian@nrao.edu, E-mail: asarma@depaul.edu [Physics Department, DePaul University, 2219 N. Kenmore Avenue, Byrne Hall 211, Chicago, IL 60614 (United States)

2017-01-10

We report detection of the Zeeman effect in the 44 GHz Class I methanol maser line, toward the star-forming region DR21(OH). In a 219 Jy beam{sup −1} maser centered at an LSR velocity of 0.83 km s{sup −1}, we find a 20- σ detection of zB {sub los} = 53.5 ± 2.7 Hz. If 44 GHz methanol masers are excited at n ∼ 10{sup 7–8} cm{sup −3}, then the B versus n {sup 1/2} relation would imply, from comparison with Zeeman effect detections in the CN(1 − 0) line toward DR21(OH), that magnetic fields traced by 44 GHz methanol masers in DR21(OH) should be ∼10 mG. Combined with our detected zB {sub los} = 53.5 Hz, this would imply that the value of the 44 GHz methanol Zeeman splitting factor z is ∼5 Hz mG{sup −1}. Such small values of z would not be a surprise, as the methanol molecule is non-paramagnetic, like H{sub 2}O. Empirical attempts to determine z , as demonstrated, are important because there currently are no laboratory measurements or theoretically calculated values of z for the 44 GHz CH{sub 3}OH transition. Data from observations of a larger number of sources are needed to make such empirical determinations robust.

Pitfalls of Insulin Pump Clocks

Science.gov (United States)

Reed, Amy J.

2014-01-01

The objective was to raise awareness about the importance of ensuring that insulin pumps internal clocks are set up correctly at all times. This is a very important safety issue because all commercially available insulin pumps are not GPS-enabled (though this is controversial), nor equipped with automatically adjusting internal clocks. Special attention is paid to how basal and bolus dose errors can be introduced by daylight savings time changes, travel across time zones, and am-pm clock errors. Correct setting of insulin pump internal clock is crucial for appropriate insulin delivery. A comprehensive literature review is provided, as are illustrative cases. Incorrect setting can potentially result in incorrect insulin delivery, with potential harmful consequences, if too much or too little insulin is delivered. Daylight saving time changes may not significantly affect basal insulin delivery, given the triviality of the time difference. However, bolus insulin doses can be dramatically affected. Such problems may occur when pump wearers have large variations in their insulin to carb ratio, especially if they forget to change their pump clock in the spring. More worrisome than daylight saving time change is the am-pm clock setting. If this setting is set up incorrectly, both basal rates and bolus doses will be affected. Appropriate insulin delivery through insulin pumps requires correct correlation between dose settings and internal clock time settings. Because insulin pumps are not GPS-enabled or automatically time-adjusting, extra caution should be practiced by patients to ensure correct time settings at all times. Clinicians and diabetes educators should verify the date/time of insulin pumps during patients’ visits, and should remind their patients to always verify these settings. PMID:25355713

GPS satellite clock determination in case of inter-frequency clock biases for triple-frequency precise point positioning

Science.gov (United States)

Guo, Jiang; Geng, Jianghui

2017-12-01

Significant time-varying inter-frequency clock biases (IFCBs) within GPS observations prevent the application of the legacy L1/L2 ionosphere-free clock products on L5 signals. Conventional approaches overcoming this problem are to estimate L1/L5 ionosphere-free clocks in addition to their L1/L2 counterparts or to compute IFCBs between the L1/L2 and L1/L5 clocks which are later modeled through a harmonic analysis. In contrast, we start from the undifferenced uncombined GNSS model and propose an alternative approach where a second satellite clock parameter dedicated to the L5 signals is estimated along with the legacy L1/L2 clock. In this manner, we do not need to rely on the correlated L1/L2 and L1/L5 ionosphere-free observables which complicates triple-frequency GPS stochastic models, or account for the unfavorable time-varying hardware biases in undifferenced GPS functional models since they can be absorbed by the L5 clocks. An extra advantage over the ionosphere-free model is that external ionosphere constraints can potentially be introduced to improve PPP. With 27 days of triple-frequency GPS data from globally distributed stations, we find that the RMS of the positioning differences between our GPS model and all conventional models is below 1 mm for all east, north and up components, demonstrating the effectiveness of our model in addressing triple-frequency observations and time-varying IFCBs. Moreover, we can combine the L1/L2 and L5 clocks derived from our model to calculate precisely the L1/L5 clocks which in practice only depart from their legacy counterparts by less than 0.006 ns in RMS. Our triple-frequency GPS model proves convenient and efficient in combating time-varying IFCBs and can be generalized to more than three frequency signals for satellite clock determination.

Decamp Clock Board Firmware

Energy Technology Data Exchange (ETDEWEB)

Vicente, J. de; Castilla, J.; Martinez, G.

2007-09-27

Decamp (Dark Energy Survey Camera) is a new instrument designed to explore the universe aiming to reveal the nature of Dark Energy. The camera consists of 72 CCDs and 520 Mpixels. The readout electronics of DECam is based on the Monsoon system. Monsoon is a new image acquisition system developed by the NOAO (National Optical Astronomical Observatory) for the new generation of astronomical cameras. The Monsoon system uses three types of boards inserted in a Eurocard format based crate: master control board, acquisition board and clock board. The direct use of the Monsoon system for DECam readout electronics requires nine crates mainly due to the high number of clock boards needed. Unfortunately, the available space for DECam electronics is constrained to four crates at maximum. The major drawback to achieve such desired compaction degree resides in the clock board signal density. This document describes the changes performed at CIEMAT on the programmable logic of the Monsoon clock board aiming to meet such restricted space constraints. (Author) 5 refs.

Decamp Clock Board Firmware

International Nuclear Information System (INIS)

Vicente, J. de; Castilla, J.; Martinez, G.

2007-01-01

Decamp (Dark Energy Survey Camera) is a new instrument designed to explore the universe aiming to reveal the nature of Dark Energy. The camera consists of 72 CCDs and 520 Mpixels. The readout electronics of DECam is based on the Monsoon system. Monsoon is a new image acquisition system developed by the NOAO (National Optical Astronomical Observatory) for the new generation of astronomical cameras. The Monsoon system uses three types of boards inserted in a Eurocard format based crate: master control board, acquisition board and clock board. The direct use of the Monsoon system for DECam readout electronics requires nine crates mainly due to the high number of clock boards needed. Unfortunately, the available space for DECam electronics is constrained to four crates at maximum. The major drawback to achieve such desired compaction degree resides in the clock board signal density. This document describes the changes performed at CIEMAT on the programmable logic of the Monsoon clock board aiming to meet such restricted space constraints. (Author) 5 refs

The nonlinear theory of slow-wave electron cyclotron masers with inclusion of the beam velocity spread

International Nuclear Information System (INIS)

Kong, Ling-Bao; Wang, Hong-Yu; Hou, Zhi-Ling; Jin, Hai-Bo; Du, Chao-Hai

2013-01-01

The nonlinear theory of slow-wave electron cyclotron masers (ECM) with an initially straight electron beam is developed. The evolution equation of the nonlinear beam electron energy is derived. The numerical studies of the slow-wave ECM efficiency with inclusion of Gaussian beam velocity spread are presented. It is shown that the velocity spread reduces the interaction efficiency. -- Highlights: •The theory of slow-wave electron cyclotron masers is considered. •The calculation of efficiency under the resonance condition is presented. •The efficiency under Gaussian velocity spreads has been obtained

The nonlinear theory of slow-wave electron cyclotron masers with inclusion of the beam velocity spread

Energy Technology Data Exchange (ETDEWEB)

Kong, Ling-Bao, E-mail: konglingbao@gmail.com [School of Science, Beijing University of Chemical Technology, Beijing 100029 (China); Beijing Key Laboratory of Environmentally Harmful Chemicals Assessment, Beijing University of Chemical Technology, Beijing 100029 (China); Wang, Hong-Yu [School of Physics, Anshan Normal University, Anshan 114005 (China); Hou, Zhi-Ling, E-mail: houzl@mail.buct.edu.cn [School of Science, Beijing University of Chemical Technology, Beijing 100029 (China); Beijing Key Laboratory of Environmentally Harmful Chemicals Assessment, Beijing University of Chemical Technology, Beijing 100029 (China); Jin, Hai-Bo [School of Materials Science and Engineering, Beijing Institute of Technology, Beijing 100081 (China); Du, Chao-Hai [Institute of Electronics, Chinese Academy of Sciences, Beijing 100190 (China)

2013-12-15

The nonlinear theory of slow-wave electron cyclotron masers (ECM) with an initially straight electron beam is developed. The evolution equation of the nonlinear beam electron energy is derived. The numerical studies of the slow-wave ECM efficiency with inclusion of Gaussian beam velocity spread are presented. It is shown that the velocity spread reduces the interaction efficiency. -- Highlights: •The theory of slow-wave electron cyclotron masers is considered. •The calculation of efficiency under the resonance condition is presented. •The efficiency under Gaussian velocity spreads has been obtained.

Cyclotron-Resonance-Maser Arrays

International Nuclear Information System (INIS)

Kesar, A.; Lei, L.; Dikhtyar, V.; Korol, M.; Jerby, E.

1999-01-01

The cyclotron-resonance-maser (CRM) array [1] is a radiation source which consists of CRM elements coupled together under a common magnetic field. Each CRM-element employs a low-energy electron-beam which performs a cyclotron interaction with the local electromagnetic wave. These waves can be coupled together among the CRM elements, hence the interaction is coherently synchronized in the entire array. The implementation of the CRM-array approach may alleviate several technological difficulties which impede the development of single-beam gyro-devices. Furthermore, it proposes new features, such as the phased-array antenna incorporated in the CRM-array itself. The CRM-array studies may lead to the development of compact, high-power radiation sources operating at low-voltages. This paper introduces new conceptual schemes of CRM-arrays, and presents the progress in related theoretical and experimental studies in our laboratory. These include a multi-mode analysis of a CRM-array, and a first operation of this device with five carbon-fiber cathodes

Toward A Neutral Mercury Optical Lattice Clock: Determination of the Magic Wavelength for the Ultraviolet clock Transition

International Nuclear Information System (INIS)

Mejri, Sinda

2012-01-01

A lattice clock combines the advantages of ion and neutral atom based clocks, namely the recoil and first order Doppler free spectroscopy allowed by the Lamb-Dicke regime. This lattice light field shifts the energy levels of the clock transition. However a wavelength can be found where the light-shift of the clock states cancelled to first order. In this thesis, we present the latest advances in optical lattice clock with mercury atoms developed at LNE-SYRTE. After a review of the current performances of different optical clock are currently under development, we focus on the concept of optical lattice clock and the features of the mercury that make him an excellent candidate for the realization of an optical lattice clock achievement the uncertainty of the level of 10 -17 . The second part is devoted to the characterization of the mercury MOT, using a sensitive detection system, which allowed us to evaluate the temperature of different isotopes present in the MOT and have a good evidence of sub-Doppler cooling for the fermionic isotopes. The third part of this these, present the experimental aspects of the implementation and the development of the laser source required for trapping mercury atoms operating near the predicted magic wavelength. Finally, we report on the Lamb-Dicke spectroscopy of the 1S0 →3 P0 clock transition in the 199 Hg atoms confined in lattice trap. With use of the ultra-stable laser system, linked to LNE-SYRTE primary frequency reference, we have determined the center frequency of the transition for a range of lattice wavelengths and different lattice depths. Analyzing these measurement, we have carried out the first experimental determination of the magic wavelength, which is the crucial step towards achieving a highly accurate frequency standard using mercury. (author)

Detection of new southern SiO maser sources associated with Mira and symbiotic stars

International Nuclear Information System (INIS)

Allen, D.A.; Hall, P.J.; Norris, R.P.; Troup, E.R.; Wark, R.M.; Wright, A.E.

1989-01-01

In 1987 July the Parkes radio telescope was used to search for 43.12 GHz SiO maser emission from southern late-type stars. We report the discovery of such emission from 12 Mira-like systems, including the symbiotic star H1-36, and discuss the implications of our data for the symbiotic stars. We identify several M-type Mira variables with unusually low SiO/infrared flux ratios, but with present data are not able to discredit the correlation between the two parameters. In addition, we present line profiles for the only other known symbiotic maser, R Aqr, at unprecedented signal-to-noise ratio; these profiles show linearly polarized emission from several components of the source. (author)

Interferometric Observation of the Highly Polarized SiO Maser Emission from the v = 1, J = 5-4 Transition Associated with VY Canis Majoris

OpenAIRE

Shinnaga, Hiroko; Moran, James M.; Young, Ken Harbour; Ho, Paul T. P.

2004-01-01

We used the Submillimeter Array to image the SiO maser emission in the $v=1$, \\$J=5-4$ transition associated with the peculiar red supergiant VY Canis Majoris. We identified seven maser components and measured their relative positions and linear polarization properties. Five of the maser components are coincident to within about 150 mas ($\\sim$ 200 AU at the distance of 1.5 kpc); most of them may originate in the circumstellar envelope at a radius of about 50 mas from the star along with the ...

Internal Clock Drift Estimation in Computer Clusters

Directory of Open Access Journals (Sweden)

Hicham Marouani

2008-01-01

Full Text Available Most computers have several high-resolution timing sources, from the programmable interrupt timer to the cycle counter. Yet, even at a precision of one cycle in ten millions, clocks may drift significantly in a single second at a clock frequency of several GHz. When tracing the low-level system events in computer clusters, such as packet sending or reception, each computer system records its own events using an internal clock. In order to properly understand the global system behavior and performance, as reported by the events recorded on each computer, it is important to estimate precisely the clock differences and drift between the different computers in the system. This article studies the clock precision and stability of several computer systems, with different architectures. It also studies the typical network delay characteristics, since time synchronization algorithms rely on the exchange of network packets and are dependent on the symmetry of the delays. A very precise clock, based on the atomic time provided by the GPS satellite network, was used as a reference to measure clock drifts and network delays. The results obtained are of immediate use to all applications which depend on computer clocks or network time synchronization accuracy.

Photoperiodic plasticity in circadian clock neurons in insects

Directory of Open Access Journals (Sweden)

Sakiko eShiga

2013-08-01

Full Text Available Since Bünning’s observation of circadian rhythms and photoperiodism in the runner bean Phaseolus multiflorus in 1936, many studies have shown that photoperiodism is based on the circadian clock system. In insects, involvement of circadian clock genes or neurons has been recently shown in the photoperiodic control of developmental arrests, diapause. Based on molecular and neuronal studies in Drosophila melanogaster, photoperiodic changes have been reported for expression patterns of the circadian clock genes, subcellular distribution of clock proteins, fiber distribution, or the number of plausible clock neurons in different species. Photoperiod sets peaks of per or tim mRNA abundance at lights-off in Sarcophaga crassipalpis, Chymomyza costata and Protophormia terraenovae. Abundance of per and Clock mRNA changes by photoperiod in Pyrrhocoris apterus. Subcellular Per distribution in circadian clock neurons changes with photoperiod in P. terraenovae. Although photoperiodism is not known in Leucophaea maderae, under longer day length, more stomata and longer commissural fibers of circadian clock neurons have been found. These plastic changes in the circadian clock neurons could be an important constituent for photoperiodic clock mechanisms to integrate repetitive photoperiodic information and produce different outputs based on day length.

Sleep Loss Reduces the DNA-Binding of BMAL1, CLOCK, and NPAS2 to Specific Clock Genes in the Mouse Cerebral Cortex

OpenAIRE

Mongrain, Valerie; La Spada, Francesco; Curie, Thomas; Franken, Paul

2011-01-01

We have previously demonstrated that clock genes contribute to the homeostatic aspect of sleep regulation. Indeed, mutations in some clock genes modify the markers of sleep homeostasis and an increase in homeostatic sleep drive alters clock gene expression in the forebrain. Here, we investigate a possible mechanism by which sleep deprivation (SD) could alter clock gene expression by quantifying DNA-binding of the core-clock transcription factors CLOCK, NPAS2, and BMAL1 to the cis-regulatory s...

Clock gene variation in Tachycineta swallows.

Science.gov (United States)

Dor, Roi; Cooper, Caren B; Lovette, Irby J; Massoni, Viviana; Bulit, Flor; Liljesthrom, Marcela; Winkler, David W

2012-01-01

Many animals use photoperiod cues to synchronize reproduction with environmental conditions and thereby improve their reproductive success. The circadian clock, which creates endogenous behavioral and physiological rhythms typically entrained to photoperiod, is well characterized at the molecular level. Recent work provided evidence for an association between Clock poly-Q length polymorphism and latitude and, within a population, an association with the date of laying and the length of the incubation period. Despite relatively high overall breeding synchrony, the timing of clutch initiation has a large impact on the fitness of swallows in the genus Tachycineta. We compared length polymorphism in the Clock poly-Q region among five populations from five different Tachycineta species that breed across a hemisphere-wide latitudinal gradient (Fig. 1). Clock poly-Q variation was not associated with latitude; however, there was an association between Clock poly-Q allele diversity and the degree of clutch size decline within breeding seasons. We did not find evidence for an association between Clock poly-Q variation and date of clutch initiation in for any of the five Tachycineta species, nor did we found a relationship between incubation duration and Clock genotype. Thus, there is no general association between latitude, breeding phenology, and Clock polymorphism in this clade of closely related birds.Figure 1Photos of Tachycineta swallows that were used in this study: A) T. bicolor from Ithaca, New York, B) T. leucorrhoa from Chascomús, Argentina, C) T. albilinea from Hill Bank, Belize, D) T. meyeni from Puerto Varas, Chile, and E) T. thalassina from Mono Lake, California, Photographers: B: Valentina Ferretti; A, C-E: David Winkler.

A new interpretation of the feature of SiO maser spectra associated with M-type star

International Nuclear Information System (INIS)

Liu Hanping; Sun Jin

1989-09-01

There exists a systematic redshift of spectra (ν=1,2; J=1-0) of SiO masers associated with a number of late-type M stars. On the contrary, the redshift is rather small for the spectra (ν=1; J=2-1). The latter is approximately symmetrical with respect to the star. For the above, no good interpretation has been given up to now. A new redshift mechanism of SiO spectra, the mechanism of radiation frequency shift, has been derived here from the interaction between the radiation field of the star and the energy levels of the maser. Detailed calculations show that, under the influence of the radiation field of the star, the redshift of the SiO spectra (J=1-0) is more substantial than that of the spectra (J=2-1). This is consistent with the result of the observation, and shows that the non-kinematic effect of the spectra is non negligible for the SiO maser of the star. (author). 10 refs, 1 fig., 1 tab

A study of oscillation amplitude settling transients in a molecular beam maser

International Nuclear Information System (INIS)

Lefrere, P.R.; Laine, D.C.

1977-01-01

The dynamic behaviour of oscillation amplitude build-up from noise has been studied in a molecular beam maser (MBM). The three forms of growth curve, predicted theoretically, namely exponential, aperiodic and damped periodic have been observed with their associated 'times of silence'. (Auth.)

Ultradian feeding in mice not only affects the peripheral clock in the liver, but also the master clock in the brain

NARCIS (Netherlands)

Sen, Satish; Raingard, Hélène; Dumont, Stéphanie; Kalsbeek, A.; Vuillez, Patrick; Challet, Etienne

2017-01-01

Restricted feeding during the resting period causes pronounced shifts in a number of peripheral clocks, but not the central clock in the suprachiasmatic nucleus (SCN). By contrast, daily caloric restriction impacts also the light-entrained SCN clock, as indicated by shifted oscillations of clock

The Water Maser in II Zw 96: Scientific Justification

Energy Technology Data Exchange (ETDEWEB)

Wiggins, Brandon Kerry [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

2015-08-06

We propose a VLBI search to image and locate the water emission in II Zw 96. We propose 3 sites within II Zw 96 for VLBI followup (see the proposed target listing below). We request 2.5 hours of on-source integration time with the VLBA per source. The array will achieve ~ 65µJy sensitivity in K band in this time which will be sufficient to detect luminous water maser features.

Results of Using the Global Positioning System to Maintain the Time and Frequency Synchronization in the Jet Propulsion Laboratory's Deep Space Network

National Research Council Canada - National Science Library

Clements, P. A; Kirk, A; Unglaub, R

1986-01-01

The Jet Propulsion Laboratory's Deep Space Network (DSN) consists of three tracking stations located in California, Australia, and Spain, each with two hydrogen maser clocks as the time and frequency standard...

An optical clock to go

Science.gov (United States)

Ludlow, Andrew D.

2018-05-01

Bringing next-generation atomic clocks out of the lab is not an easy task, but doing so will unlock many new possibilities. As a crucial first step, a portable atomic clock has now been deployed for relativistic geodesy measurements in the Alps.

Results of using the global positioning system to maintain the time and frequency synchronization in the Deep Space Network

Science.gov (United States)

Clements, P. A.; Kirk, A.; Unglaub, R.

1987-01-01

There are two hydrogen maser clocks located at each signal processing center (SPC) in the DSN. Close coordination of the time and frequency of the SPC clocks is needed to navigate spacecraft to the outer planets. A recent example was the Voyager spacecraft's encounter with Uranus in January 1986. The clocks were adjusted with the goal of minimizing time and frequency offsets between the SPCs at encounter. How time and frequency at each SPC is estimated using data acquired from the Global Positioning System Timing Receivers operating on the NBS-BIH (National Bureau of Standards-Bureau International de l'Heure) tracking schedule is described. These data are combined with other available timing receiver data to calculate the time offset estimates. The adjustment of the clocks is described. It was determined that long range hydrogen maser drift is quite predictable and adjustable within limits. This enables one to minimize time and frequency differences between the three SPCs for many months by matching the drift rates of the three standards. Data acquisition and processing techniques using a Kalman filter to make estimates of time and frequency offsets between the clocks at the SPCs and UTC(NBS) (Coordinated Universal Time realized at NBS) are described.

Processing of visually presented clock times.

Science.gov (United States)

Goolkasian, P; Park, D C

1980-11-01

The encoding and representation of visually presented clock times was investigated in three experiments utilizing a comparative judgment task. Experiment 1 explored the effects of comparing times presented in different formats (clock face, digit, or word), and Experiment 2 examined angular distance effects created by varying positions of the hands on clock faces. In Experiment 3, encoding and processing differences between clock faces and digitally presented times were directly measured. Same/different reactions to digitally presented times were faster than to times presented on a clock face, and this format effect was found to be a result of differences in processing that occurred after encoding. Angular separation also had a limited effect on processing. The findings are interpreted within the framework of theories that refer to the importance of representational codes. The applicability to the data of Bank's semantic-coding theory, Paivio's dual-coding theory, and the levels-of-processing view of memory are discussed.

Circadian Clock genes Per2 and clock regulate steroid production, cell proliferation, and luteinizing hormone receptor transcription in ovarian granulosa cells

International Nuclear Information System (INIS)

Shimizu, Takashi; Hirai, Yuko; Murayama, Chiaki; Miyamoto, Akio; Miyazaki, Hitoshi; Miyazaki, Koyomi

2011-01-01

Highlights: → Treatment with Per2 and Clock siRNAs decreased the number of granulosa cells and LHr expression. →Per2 siRNA treatment did not stimulate the production of estradiol and expression of P450arom. → Clock siRNA treatment inhibited the production of estradiol and expression of P450arom mRNA. →Per2 and Clock siRNA treatment increased and unchanged, respectively, progesterone production in FSH-treated granulosa cells. → The expression of StAR mRNA was increased by Per2 siRNA and unchanged by Clock siRNA. -- Abstract: Circadian Clock genes are associated with the estrous cycle in female animals. Treatment with Per2 and Clock siRNAs decreased the number of granulosa cells and LHr expression in follicle-stimulating hormone FSH-treated granulosa cells. Per2 siRNA treatment did not stimulate the production of estradiol and expression of P450arom, whereas Clock siRNA treatment inhibited the production of estradiol and expression of P450arom mRNA. Per2 and Clock siRNA treatment increased and unchanged, respectively, progesterone production in FSH-treated granulosa cells. Similarly, expression of StAR mRNA was increased by Per2 siRNA and unchanged by Clock siRNA. Our data provide a new insight that Per2 and Clock have different action on ovarian granulosa cell functions.

Circadian Clock genes Per2 and clock regulate steroid production, cell proliferation, and luteinizing hormone receptor transcription in ovarian granulosa cells

Energy Technology Data Exchange (ETDEWEB)

Shimizu, Takashi, E-mail: shimizut@obihiro.ac.jp [Graduate School of Animal and Food Hygiene, Obihiro University of Agriculture and Veterinary Medicine, Obihiro, Hokkaido 080-8555 (Japan); Hirai, Yuko; Murayama, Chiaki; Miyamoto, Akio [Graduate School of Animal and Food Hygiene, Obihiro University of Agriculture and Veterinary Medicine, Obihiro, Hokkaido 080-8555 (Japan); Miyazaki, Hitoshi [Gene Research Center, University of Tsukuba, Tsukuba, Ibaraki 305-8572 (Japan); Miyazaki, Koyomi [Biomedical Research Institute, National Institute of Advanced Industrial Science and Technology (AIST) Central 6, 1-1-1, Higashi, Tsukuba, Ibaraki 305-8566 (Japan)

2011-08-19

Highlights: {yields} Treatment with Per2 and Clock siRNAs decreased the number of granulosa cells and LHr expression. {yields}Per2 siRNA treatment did not stimulate the production of estradiol and expression of P450arom. {yields} Clock siRNA treatment inhibited the production of estradiol and expression of P450arom mRNA. {yields}Per2 and Clock siRNA treatment increased and unchanged, respectively, progesterone production in FSH-treated granulosa cells. {yields} The expression of StAR mRNA was increased by Per2 siRNA and unchanged by Clock siRNA. -- Abstract: Circadian Clock genes are associated with the estrous cycle in female animals. Treatment with Per2 and Clock siRNAs decreased the number of granulosa cells and LHr expression in follicle-stimulating hormone FSH-treated granulosa cells. Per2 siRNA treatment did not stimulate the production of estradiol and expression of P450arom, whereas Clock siRNA treatment inhibited the production of estradiol and expression of P450arom mRNA. Per2 and Clock siRNA treatment increased and unchanged, respectively, progesterone production in FSH-treated granulosa cells. Similarly, expression of StAR mRNA was increased by Per2 siRNA and unchanged by Clock siRNA. Our data provide a new insight that Per2 and Clock have different action on ovarian granulosa cell functions.

NRL GPS Bibliography - An Annotated Bibliography of the Origin and Development of the Global Position System at the Naval Research Laboratory

Science.gov (United States)

2009-06-03

hardness, and control requirements on clock performance. The requirements to survive launch and operate in space produce design challenges that go...carriers set to occur at the center of the FSK transitions 143 A nn ot at ed B ib lio gr ap hy synchronization requirements to challenge crystal...for space and military programs. Most of the published data on masers has related to their short-term stability. The VLC -11 maser, one of two

The Implementation of E1 Clock Recovery

Directory of Open Access Journals (Sweden)

Wang Ziyu

2016-01-01

Full Text Available Clock transform and recovery is of significant importance in microwave TDM service, and it is always extracted from the E1 line data stream in most cases. However, intrinsically uncertain delay and jitter caused by packet transmission of E1 data information, may lead to the indexes of the data recovery clock exceed the clock performance template. Through analysis of the E1 clock indexes and measuring methods, this paper proposes a new clock recovery method. The method employs two buffers, the first RAM is used as a buffer to deduct excess information, and the second FIFO is used as a buffer to recovery the clock and data. The first buffer has a feedback from the second one, and is able to actively respond to changes in the data link and requests from the second one. The test results validate the effectiveness of the method, and the corresponding scheme is also valuable for the other communication systems.

A model of guarded recursion with clock synchronisation

DEFF Research Database (Denmark)

Bizjak, Aleš; Møgelberg, Rasmus Ejlers

2015-01-01

productivity to be captured in types. The calculus uses clocks representing time streams and clock quantifiers which allow limited and controlled elimination of modalities. The calculus has since been extended to dependent types by Møgelberg. Both works give denotational semantics but no rewrite semantics....... In previous versions of this calculus, different clocks represented separate time streams and clock synchronisation was prohibited. In this paper we show that allowing clock synchronisation is safe by constructing a new model of guarded recursion and clocks. This result will greatly simplify the type theory...... by removing freshness restrictions from typing rules, and is a necessary step towards defining rewrite semantics, and ultimately implementing the calculus....

Global synchronization of parallel processors using clock pulse width modulation

Science.gov (United States)

Chen, Dong; Ellavsky, Matthew R.; Franke, Ross L.; Gara, Alan; Gooding, Thomas M.; Haring, Rudolf A.; Jeanson, Mark J.; Kopcsay, Gerard V.; Liebsch, Thomas A.; Littrell, Daniel; Ohmacht, Martin; Reed, Don D.; Schenck, Brandon E.; Swetz, Richard A.

2013-04-02

A circuit generates a global clock signal with a pulse width modification to synchronize processors in a parallel computing system. The circuit may include a hardware module and a clock splitter. The hardware module may generate a clock signal and performs a pulse width modification on the clock signal. The pulse width modification changes a pulse width within a clock period in the clock signal. The clock splitter may distribute the pulse width modified clock signal to a plurality of processors in the parallel computing system.

Induction linac driven relativistic klystron and cyclotron autoresonance maser experiments

International Nuclear Information System (INIS)

Goodman, D.L.; Birx, D.L.; Danly, B.G.

1991-01-01

In this paper design and experimental results are presented from two high power microwave generation experiments utilizing a high repetition rate induction linac generated electron beam. A relativistic klystron has generated more than 100 MW microwave pulses in X-band for 50 ns without pulse shortening or breakdown. design studies for the first cyclotron autoresonance maser (CARM) amplifier using an induction linac electron beam are also presented

Space experiments with high stability clocks

International Nuclear Information System (INIS)

Vessot, R.F.C.

1993-01-01

Modern metrology depends increasingly on the accuracy and frequency stability of atomic clocks. Applications of such high-stability oscillators (or clocks) to experiments performed in space are described and estimates of the precision of these experiments are made in terms of clock performance. Methods using time-correlation to cancel localized disturbances in very long signal paths and a proposed space borne four station VLBI system are described. (TEC). 30 refs., 14 figs., 1 tab

Unusual H2O maser source near Herbig-Haro object number 11

International Nuclear Information System (INIS)

Lo, K.Y.; Morris, M.; Moran, J.M.; Haschick, A.D.

1976-01-01

Water emission spectra of an unusual source near Herbig-Haro (HH) 11 have been monitored over a 14-month period. Variations in the intensity and the radial velocity of the emission are noticeable on time scales as short as one day. At any given time, only one or two velocity components are present in the spectrum. The variations are such that each component appears and disappears at a fixed radial velocity, and new components appear at seemingly random velocities within a 40 km s -1 range. It is suggested that the exciting source is losing mass via a stellar wind, and that the H 2 O emission arises in the transition region between the cavity created by the stellar wind and the surrounding molecular medium. The proposed model can be tested by VLBI observations; an accurate position for the H 2 O maser source is required to determine the physical relationship between the maser source and the infrared or HH objects

Geodesy and metrology with a transportable optical clock

Science.gov (United States)

Grotti, Jacopo; Koller, Silvio; Vogt, Stefan; Häfner, Sebastian; Sterr, Uwe; Lisdat, Christian; Denker, Heiner; Voigt, Christian; Timmen, Ludger; Rolland, Antoine; Baynes, Fred N.; Margolis, Helen S.; Zampaolo, Michel; Thoumany, Pierre; Pizzocaro, Marco; Rauf, Benjamin; Bregolin, Filippo; Tampellini, Anna; Barbieri, Piero; Zucco, Massimo; Costanzo, Giovanni A.; Clivati, Cecilia; Levi, Filippo; Calonico, Davide

2018-05-01

Optical atomic clocks, due to their unprecedented stability1-3 and uncertainty3-6, are already being used to test physical theories7,8 and herald a revision of the International System of Units9,10. However, to unlock their potential for cross-disciplinary applications such as relativistic geodesy11, a major challenge remains: their transformation from highly specialized instruments restricted to national metrology laboratories into flexible devices deployable in different locations12-14. Here, we report the first field measurement campaign with a transportable 87Sr optical lattice clock12. We use it to determine the gravity potential difference between the middle of a mountain and a location 90 km away, exploiting both local and remote clock comparisons to eliminate potential clock errors. A local comparison with a 171Yb lattice clock15 also serves as an important check on the international consistency of independently developed optical clocks. This campaign demonstrates the exciting prospects for transportable optical clocks.

Long-Term Clock Behavior of GPS IIR Satellites

National Research Council Canada - National Science Library

Epstein, Marvin; Dass, Todd; Rajan, John; Gilmour, Paul

2007-01-01

.... Rubidium clocks, as opposed to cesium clocks, have significant long-term drift. The current literature describes an initial model of drift aging for rubidium atomic clocks followed by a long-term characteristic...

Rubidium-Fountain Characterization Using the USNO Clock Ensemble

National Research Council Canada - National Science Library

Peil, Steven; Crane, Scott; Swanson, Thomas B; Ekstrom, Christopher R

2007-01-01

.... Long, continuous runs of the prototype system allow us to demonstrate fractional frequency-stability comparisons to the Maser Mean that integrate as white frequency noise, with a stability of 5 10(exp -16) at one day...

Geometry of VY Canis Majoris derived from SiO maser lines

International Nuclear Information System (INIS)

Van Blerkom, D.; Auer, L.

1976-01-01

A radiation reveals transfer calculation reveals that the SiO maser lines observed in the spectrum of VY CMa are formed in a rotating equatorial disk seen nearly edge-on. Other geometries are considered and eliminated. It is suggested that the SiO lines of NML Cyg also show evidence that they are formed in a disk

Dense Molecular Gas and H2O Maser Emission in Galaxies F ...

Indian Academy of Sciences (India)

2School of Physics and Telecommunication Engineering, South China Normal University,. Guangzhou 510006, China. ∗ e-mail: jszhang@gzhu.edu.cn. Abstract. Extragalactic H2O masers have been found in dense gas cir- cumstance in off-nuclear star formation regions or within parsecs of. Active Galactic Nuclei (AGNs).

Sound Clocks and Sonic Relativity

Science.gov (United States)

Todd, Scott L.; Menicucci, Nicolas C.

2017-10-01

Sound propagation within certain non-relativistic condensed matter models obeys a relativistic wave equation despite such systems admitting entirely non-relativistic descriptions. A natural question that arises upon consideration of this is, "do devices exist that will experience the relativity in these systems?" We describe a thought experiment in which `acoustic observers' possess devices called sound clocks that can be connected to form chains. Careful investigation shows that appropriately constructed chains of stationary and moving sound clocks are perceived by observers on the other chain as undergoing the relativistic phenomena of length contraction and time dilation by the Lorentz factor, γ , with c the speed of sound. Sound clocks within moving chains actually tick less frequently than stationary ones and must be separated by a shorter distance than when stationary to satisfy simultaneity conditions. Stationary sound clocks appear to be length contracted and time dilated to moving observers due to their misunderstanding of their own state of motion with respect to the laboratory. Observers restricted to using sound clocks describe a universe kinematically consistent with the theory of special relativity, despite the preferred frame of their universe in the laboratory. Such devices show promise in further probing analogue relativity models, for example in investigating phenomena that require careful consideration of the proper time elapsed for observers.

Astrometrically registered simultaneous observations of the 22 GHz H{sub 2}O and 43 GHz SiO masers toward R Leonis Minoris using KVN and source/frequency phase referencing

Energy Technology Data Exchange (ETDEWEB)

Dodson, Richard; Rioja, María J.; Jung, Tae-Hyun; Sohn, Bong-Won; Byun, Do-Young; Cho, Se-Hyung; Lee, Sang-Sung; Kim, Jongsoo; Kim, Kee-Tae; Oh, Chung-Sik; Han, Seog-Tae; Je, Do-Heung; Chung, Moon-Hee; Wi, Seog-Oh; Kang, Jiman; Lee, Jung-Won; Chung, Hyunsoo; Kim, Hyo-Ryoung; Kim, Hyun-Goo; Lee, Chang-Hoon, E-mail: rdodson@kasi.re.kr [Korea Astronomy and Space Science Institute, Daedeokdae-ro 776, Yuseong-gu, Daejeon 305-348 (Korea, Republic of); and others

2014-11-01

Oxygen-rich asymptotic giant branch (AGB) stars can be intense emitters of SiO (v = 1 and 2, J = 1 → 0) and H{sub 2}O maser lines at 43 and 22 GHz, respectively. Very long baseline interferometry (VLBI) observations of the maser emission provide a unique tool to probe the innermost layers of the circumstellar envelopes in AGB stars. Nevertheless, the difficulties in achieving astrometrically aligned H{sub 2}O and v = 1 and v = 2 SiO maser maps have traditionally limited the physical constraints that can be placed on the SiO maser pumping mechanism. We present phase-referenced simultaneous spectral-line VLBI images for the SiO v = 1 and v = 2, J = 1 → 0, and H{sub 2}O maser emission around the AGB star R LMi, obtained from the Korean VLBI Network (KVN). The simultaneous multi-channel receivers of the KVN offer great possibilities for astrometry in the frequency domain. With this facility, we have produced images with bona fide absolute astrometric registration between high-frequency maser transitions of different species to provide the positions of the H{sub 2}O maser emission and the center of the SiO maser emission, hence reducing the uncertainty in the proper motions for R LMi by an order of magnitude over that from Hipparcos. This is the first successful demonstration of source frequency phase referencing for millimeter VLBI spectral-line observations and also where the ratio between the frequencies is not an integer.

Sleep loss reduces the DNA-binding of BMAL1, CLOCK, and NPAS2 to specific clock genes in the mouse cerebral cortex.

Directory of Open Access Journals (Sweden)

Valérie Mongrain

Full Text Available We have previously demonstrated that clock genes contribute to the homeostatic aspect of sleep regulation. Indeed, mutations in some clock genes modify the markers of sleep homeostasis and an increase in homeostatic sleep drive alters clock gene expression in the forebrain. Here, we investigate a possible mechanism by which sleep deprivation (SD could alter clock gene expression by quantifying DNA-binding of the core-clock transcription factors CLOCK, NPAS2, and BMAL1 to the cis-regulatory sequences of target clock genes in mice. Using chromatin immunoprecipitation (ChIP, we first showed that, as reported for the liver, DNA-binding of CLOCK and BMAL1 to target clock genes changes in function of time-of-day in the cerebral cortex. Tissue extracts were collected at ZT0 (light onset, -6, -12, and -18, and DNA enrichment of E-box or E'-box containing sequences was measured by qPCR. CLOCK and BMAL1 binding to Cry1, Dbp, Per1, and Per2 depended on time-of-day, with maximum values reached at around ZT6. We then observed that SD, performed between ZT0 and -6, significantly decreased DNA-binding of CLOCK and BMAL1 to Dbp, consistent with the observed decrease in Dbp mRNA levels after SD. The DNA-binding of NPAS2 and BMAL1 to Per2 was also decreased by SD, although SD is known to increase Per2 expression in the cortex. DNA-binding to Per1 and Cry1 was not affected by SD. Our results show that the sleep-wake history can affect the clock molecular machinery directly at the level of chromatin binding thereby altering the cortical expression of Dbp and Per2 and likely other targets. Although the precise dynamics of the relationship between DNA-binding and mRNA expression, especially for Per2, remains elusive, the results also suggest that part of the reported circadian changes in DNA-binding of core clock components in tissues peripheral to the suprachiasmatic nuclei could, in fact, be sleep-wake driven.

Sleep loss reduces the DNA-binding of BMAL1, CLOCK, and NPAS2 to specific clock genes in the mouse cerebral cortex.

Science.gov (United States)

Mongrain, Valérie; La Spada, Francesco; Curie, Thomas; Franken, Paul

2011-01-01

We have previously demonstrated that clock genes contribute to the homeostatic aspect of sleep regulation. Indeed, mutations in some clock genes modify the markers of sleep homeostasis and an increase in homeostatic sleep drive alters clock gene expression in the forebrain. Here, we investigate a possible mechanism by which sleep deprivation (SD) could alter clock gene expression by quantifying DNA-binding of the core-clock transcription factors CLOCK, NPAS2, and BMAL1 to the cis-regulatory sequences of target clock genes in mice. Using chromatin immunoprecipitation (ChIP), we first showed that, as reported for the liver, DNA-binding of CLOCK and BMAL1 to target clock genes changes in function of time-of-day in the cerebral cortex. Tissue extracts were collected at ZT0 (light onset), -6, -12, and -18, and DNA enrichment of E-box or E'-box containing sequences was measured by qPCR. CLOCK and BMAL1 binding to Cry1, Dbp, Per1, and Per2 depended on time-of-day, with maximum values reached at around ZT6. We then observed that SD, performed between ZT0 and -6, significantly decreased DNA-binding of CLOCK and BMAL1 to Dbp, consistent with the observed decrease in Dbp mRNA levels after SD. The DNA-binding of NPAS2 and BMAL1 to Per2 was also decreased by SD, although SD is known to increase Per2 expression in the cortex. DNA-binding to Per1 and Cry1 was not affected by SD. Our results show that the sleep-wake history can affect the clock molecular machinery directly at the level of chromatin binding thereby altering the cortical expression of Dbp and Per2 and likely other targets. Although the precise dynamics of the relationship between DNA-binding and mRNA expression, especially for Per2, remains elusive, the results also suggest that part of the reported circadian changes in DNA-binding of core clock components in tissues peripheral to the suprachiasmatic nuclei could, in fact, be sleep-wake driven.

Novel transcriptional networks regulated by CLOCK in human neurons.

Science.gov (United States)

Fontenot, Miles R; Berto, Stefano; Liu, Yuxiang; Werthmann, Gordon; Douglas, Connor; Usui, Noriyoshi; Gleason, Kelly; Tamminga, Carol A; Takahashi, Joseph S; Konopka, Genevieve

2017-11-01

The molecular mechanisms underlying human brain evolution are not fully understood; however, previous work suggested that expression of the transcription factor CLOCK in the human cortex might be relevant to human cognition and disease. In this study, we investigated this novel transcriptional role for CLOCK in human neurons by performing chromatin immunoprecipitation sequencing for endogenous CLOCK in adult neocortices and RNA sequencing following CLOCK knockdown in differentiated human neurons in vitro. These data suggested that CLOCK regulates the expression of genes involved in neuronal migration, and a functional assay showed that CLOCK knockdown increased neuronal migratory distance. Furthermore, dysregulation of CLOCK disrupts coexpressed networks of genes implicated in neuropsychiatric disorders, and the expression of these networks is driven by hub genes with human-specific patterns of expression. These data support a role for CLOCK-regulated transcriptional cascades involved in human brain evolution and function. © 2017 Fontenot et al.; Published by Cold Spring Harbor Laboratory Press.

NEW MASER EMISSION FROM NONMETASTABLE AMMONIA IN NGC 7538. III. DETECTION OF THE (10,6) TRANSITION AND A VELOCITY GRADIENT

Energy Technology Data Exchange (ETDEWEB)

Hoffman, Ian M., E-mail: ihoffman@wittenberg.edu [Physics Department Wittenberg University, Springfield, OH 45501 (United States)

2012-11-01

We present the first astronomical detection of the {sup 14}NH{sub 3} (J, K) = (10, 6) line: nonthermal emission at several velocities in the Galactic star-forming region NGC 7538. Using the Very Large Array we have imaged the (10,6) and (9,6) ammonia masers at several positions within NGC 7538 IRS 1. The individual sources have angular sizes {approx}< 0.1 arcsec corresponding to brightness temperatures T{sub B} {approx}> 10{sup 6} K. We apply the pumping model of Brown and Cragg, confirming the conjecture that multiple ortho-ammonia masers can occur with the same value of K. The positions and velocities of the (10,6) and (9,6) masers are modeled as motion in a possible disk or torus and are discussed in the context of recent models of the region.

Naming analog clocks conceptually facilitates naming digital clocks

NARCIS (Netherlands)

Meeuwissen, M.H.W.; Roelofs, A.P.A.; Levelt, W.J.M.

2004-01-01

Naming digital clocks (e.g., 2:45, say "quarter to three") requires conceptual operations on the minute and hour information displayed in the input for producing the correct relative time expression. The interplay of these conceptual operations was investigated using a repetition priming paradigm.

Optical lattice clock with Strontium atoms

International Nuclear Information System (INIS)

Baillard, X.

2008-01-01

This thesis presents the latest achievements regarding the optical lattice clock with Strontium atoms developed at LNE-SYRTE. After a review of the different types of optical clocks that are currently under development, we stress on the concept of optical lattice clock which was first imagined for Sr 87 using the 1 S 0 → 3 P 0 transition. We exhibit the features of this atom, in particular the concept of magic wavelength for the trap, and the achievable performances for this kind of clock. The second part presents the experimental aspects, insisting particularly on the ultra-stable laser used for the interrogation of the atoms which is a central part of the experiment. Among the latest improvements, an optical pumping phase and an interrogation phase using a magnetic field have been added in order to refine the evaluation of the Zeeman effect. Finally, the last part presents the experimental results. The last evaluation of the clock using Sr 87 atoms allowed us to reach a frequency accuracy of 2.6*10 -15 and a measurement in agreement with the one made at JILA (Tokyo university) at the 10 -15 level. On another hand, thanks to recent theoretical proposals, we made a measurement using the bosonic isotope Sr 88 by adapting the experimental setup. This measurement represents the first evaluation for this type of clock, with a frequency accuracy of 7*10 -14 . (author)

The general particle tracer code applied to the fusion free-electron maser

NARCIS (Netherlands)

de Loos, M. J.; van der Geer, S. B.; van der Geer, C. A. J.; Verhoeven, A. G. A.; Urbanus, W. H.

1998-01-01

The fusion Free-Electron Maser (FEM) is the prototype of a high power, electrostatic mm-wave source, tunable in the range 130-260 GHz. In order to achieve a high overall efficiency, the charge and energy of the spent electron beam, i.e. the beam which leaves the undulator after interaction with the

Magnetically aligned dust and SiO maser polarisation in the envelope of the red supergiant VY Canis Majoris

Science.gov (United States)

Vlemmings, W. H. T.; Khouri, T.; Martí-Vidal, I.; Tafoya, D.; Baudry, A.; Etoka, S.; Humphreys, E. M. L.; Jones, T. J.; Kemball, A.; O'Gorman, E.; Pérez-Sánchez, A. F.; Richards, A. M. S.

2017-07-01

Aims: Polarisation observations of circumstellar dust and molecular (thermal and maser) lines provide unique information about dust properties and magnetic fields in circumstellar envelopes of evolved stars. Methods: We use Atacama Large Millimeter/submillimeter Array (ALMA) Band 5 science verification observations of the red supergiant VY CMa to study the polarisation of SiO thermal/maser lines and dust continuum at 1.7 mm wavelength. We analyse both linear and circular polarisation and derive the magnetic field strength and structure, assuming the polarisation of the lines originates from the Zeeman effect, and that of the dust originates from aligned dust grains. We also discuss other effects that could give rise to the observed polarisation. Results: We detect, for the first time, significant polarisation ( 3%) of the circumstellar dust emission at millimeter wavelengths. The polarisation is uniform with an electric vector position angle of 8°. Varying levels of linear polarisation are detected for the J = 4 - 328SiO v = 0, 1, 2, and 29SiO v = 0, 1 lines, with the strongest polarisation fraction of 30% found for the 29SiO v = 1 maser. The linear polarisation vectors rotate with velocity, consistent with earlier observations. We also find significant (up to 1%) circular polarisation in several lines, consistent with previous measurements. We conclude that the detection is robust against calibration and regular instrumental errors, although we cannot yet fully rule out non-standard instrumental effects. Conclusions: Emission from magnetically aligned grains is the most likely origin of the observed continuum polarisation. This implies that the dust is embedded in a magnetic field >13 mG. The maser line polarisation traces the magnetic field structure. The magnetic field in the gas and dust is consistent with an approximately toroidal field configuration, but only higher angular resolution observations will be able to reveal more detailed field structure. If the

Transcripts from the Circadian Clock: Telling Time and Season

NARCIS (Netherlands)

K. Brand (Karl)

2011-01-01

textabstractWe all know it when we wake mere moments before an alarm clock is scheduled to wake us: our body clock made the alarm clock redundant. This phenomenon is driven by an endogenous timer known as the biological, or circadian clock. Each revolution of the Earth about its own axis produces

H2O maser flare in Orion A

International Nuclear Information System (INIS)

Matveenko, L.I.; Moran, J.M.; Genzel, R.

1982-01-01

The flare of H 2 O maser emission in Orion A was observed with the Crimea--Effelsberg and Haystack--Green Bank interferometers in November 1979. Its position is α = 5/sup h/32/sup m/46/sup s/.6 +- 0/sup s/.06, delta = -5 0 24'.28''.7 +- 1'' (1950.0); its radial velocity, 8 km/sec. The asymmetric line profile has a 28-kHz halfwidth. The flare source comprises a 0''.0005 core (T/sub b/ = 5 x 10 16 0 K) embedded in a 0''.005 halo (T/sub b/ = 3 x 10 14 0 K)

Biological timing and the clock metaphor: oscillatory and hourglass mechanisms.

Science.gov (United States)

Rensing, L; Meyer-Grahle, U; Ruoff, P

2001-05-01

Living organisms have developed a multitude of timing mechanisms--"biological clocks." Their mechanisms are based on either oscillations (oscillatory clocks) or unidirectional processes (hourglass clocks). Oscillatory clocks comprise circatidal, circalunidian, circadian, circalunar, and circannual oscillations--which keep time with environmental periodicities--as well as ultradian oscillations, ovarian cycles, and oscillations in development and in the brain, which keep time with biological timescales. These clocks mainly determine time points at specific phases of their oscillations. Hourglass clocks are predominantly found in development and aging and also in the brain. They determine time intervals (duration). More complex timing systems combine oscillatory and hourglass mechanisms, such as the case for cell cycle, sleep initiation, or brain clocks, whereas others combine external and internal periodicities (photoperiodism, seasonal reproduction). A definition of a biological clock may be derived from its control of functions external to its own processes and its use in determining temporal order (sequences of events) or durations. Biological and chemical oscillators are characterized by positive and negative feedback (or feedforward) mechanisms. During evolution, living organisms made use of the many existing oscillations for signal transmission, movement, and pump mechanisms, as well as for clocks. Some clocks, such as the circadian clock, that time with environmental periodicities are usually compensated (stabilized) against temperature, whereas other clocks, such as the cell cycle, that keep time with an organismic timescale are not compensated. This difference may be related to the predominance of negative feedback in the first class of clocks and a predominance of positive feedback (autocatalytic amplification) in the second class. The present knowledge of a compensated clock (the circadian oscillator) and an uncompensated clock (the cell cycle), as well

The Square Light Clock and Special Relativity

Science.gov (United States)

Galli, J. Ronald; Amiri, Farhang

2012-01-01

A thought experiment that includes a square light clock is similar to the traditional vertical light beam and mirror clock, except it is made up of four mirrors placed at a 45[degree] angle at each corner of a square of length L[subscript 0], shown in Fig. 1. Here we have shown the events as measured in the rest frame of the square light clock. By…

A precise clock distribution network for MRPC-based experiments

International Nuclear Information System (INIS)

Wang, S.; Cao, P.; Shang, L.; An, Q.

2016-01-01

In high energy physics experiments, the MRPC (Multi-Gap Resistive Plate Chamber) detectors are widely used recently which can provide higher-resolution measurement for particle identification. However, the application of MRPC detectors leads to a series of challenges in electronics design with large number of front-end electronic channels, especially for distributing clock precisely. To deal with these challenges, this paper presents a universal scheme of clock transmission network for MRPC-based experiments with advantages of both precise clock distribution and global command synchronization. For precise clock distributing, the clock network is designed into a tree architecture with two stages: the first one has a point-to-multipoint long range bidirectional distribution with optical channels and the second one has a fan-out structure with copper link inside readout crates. To guarantee the precision of clock frequency or phase, the r-PTP (reduced Precision Time Protocol) and the DDMTD (digital Dual Mixer Time Difference) methods are used for frequency synthesis, phase measurement and adjustment, which is implemented by FPGA (Field Programmable Gate Array) in real-time. In addition, to synchronize global command execution, based upon this clock distribution network, synchronous signals are coded with clock for transmission. With technique of encoding/decoding and clock data recovery, signals such as global triggers or system control commands, can be distributed to all front-end channels synchronously, which greatly simplifies the system design. The experimental results show that both the clock jitter (RMS) and the clock skew can be less than 100 ps.

Relativity theory and time perception: single or multiple clocks?

Science.gov (United States)

Buhusi, Catalin V; Meck, Warren H

2009-07-22

Current theories of interval timing assume that humans and other animals time as if using a single, absolute stopwatch that can be stopped or reset on command. Here we evaluate the alternative view that psychological time is represented by multiple clocks, and that these clocks create separate temporal contexts by which duration is judged in a relative manner. Two predictions of the multiple-clock hypothesis were tested. First, that the multiple clocks can be manipulated (stopped and/or reset) independently. Second, that an event of a given physical duration would be perceived as having different durations in different temporal contexts, i.e., would be judged differently by each clock. Rats were trained to time three durations (e.g., 10, 30, and 90 s). When timing was interrupted by an unexpected gap in the signal, rats reset the clock used to time the "short" duration, stopped the "medium" duration clock, and continued to run the "long" duration clock. When the duration of the gap was manipulated, the rats reset these clocks in a hierarchical order, first the "short", then the "medium", and finally the "long" clock. Quantitative modeling assuming re-allocation of cognitive resources in proportion to the relative duration of the gap to the multiple, simultaneously timed event durations was used to account for the results. These results indicate that the three event durations were effectively timed by separate clocks operated independently, and that the same gap duration was judged relative to these three temporal contexts. Results suggest that the brain processes the duration of an event in a manner similar to Einstein's special relativity theory: A given time interval is registered differently by independent clocks dependent upon the context.

Relativity theory and time perception: single or multiple clocks?

Directory of Open Access Journals (Sweden)

Catalin V Buhusi

2009-07-01

Full Text Available Current theories of interval timing assume that humans and other animals time as if using a single, absolute stopwatch that can be stopped or reset on command. Here we evaluate the alternative view that psychological time is represented by multiple clocks, and that these clocks create separate temporal contexts by which duration is judged in a relative manner. Two predictions of the multiple-clock hypothesis were tested. First, that the multiple clocks can be manipulated (stopped and/or reset independently. Second, that an event of a given physical duration would be perceived as having different durations in different temporal contexts, i.e., would be judged differently by each clock.Rats were trained to time three durations (e.g., 10, 30, and 90 s. When timing was interrupted by an unexpected gap in the signal, rats reset the clock used to time the "short" duration, stopped the "medium" duration clock, and continued to run the "long" duration clock. When the duration of the gap was manipulated, the rats reset these clocks in a hierarchical order, first the "short", then the "medium", and finally the "long" clock. Quantitative modeling assuming re-allocation of cognitive resources in proportion to the relative duration of the gap to the multiple, simultaneously timed event durations was used to account for the results.These results indicate that the three event durations were effectively timed by separate clocks operated independently, and that the same gap duration was judged relative to these three temporal contexts. Results suggest that the brain processes the duration of an event in a manner similar to Einstein's special relativity theory: A given time interval is registered differently by independent clocks dependent upon the context.

A Novel Method of Clock Synchronization in Distributed Systems

Science.gov (United States)

Li, Gun; Niu, Meng-jie; Chai, Yang-shun; Chen, Xin; Ren, Yan-qiu

2017-04-01

Time synchronization plays an important role in the spacecraft formation flight and constellation autonomous navigation, etc. For the application of clock synchronization in a network system, it is not always true that all the observed nodes in the network are interconnected, therefore, it is difficult to achieve the high-precision time synchronization of a network system in the condition that a certain node can only obtain the measurement information of clock from a single neighboring node, but cannot obtain it from other nodes. Aiming at this problem, a novel method of high-precision time synchronization in a network system is proposed. In this paper, each clock is regarded as a node in the network system, and based on the definition of different topological structures of a distributed system, the three control algorithms of time synchronization under the following three cases are designed: without a master clock (reference clock), with a master clock (reference clock), and with a fixed communication delay in the network system. And the validity of the designed clock synchronization protocol is proved by both stability analysis and numerical simulation.

Physical Layer Ethernet Clock Synchronization

Science.gov (United States)

2010-11-01

42 nd Annual Precise Time and Time Interval (PTTI) Meeting 77 PHYSICAL LAYER ETHERNET CLOCK SYNCHRONIZATION Reinhard Exel, Georg...oeaw.ac.at Nikolaus Kerö Oregano Systems, Mohsgasse 1, 1030 Wien, Austria E-mail: nikolaus.keroe@oregano.at Abstract Clock synchronization ...is a service widely used in distributed networks to coordinate data acquisition and actions. As the requirement to achieve tighter synchronization

A clock network for geodesy and fundamental science.

Science.gov (United States)

Lisdat, C; Grosche, G; Quintin, N; Shi, C; Raupach, S M F; Grebing, C; Nicolodi, D; Stefani, F; Al-Masoudi, A; Dörscher, S; Häfner, S; Robyr, J-L; Chiodo, N; Bilicki, S; Bookjans, E; Koczwara, A; Koke, S; Kuhl, A; Wiotte, F; Meynadier, F; Camisard, E; Abgrall, M; Lours, M; Legero, T; Schnatz, H; Sterr, U; Denker, H; Chardonnet, C; Le Coq, Y; Santarelli, G; Amy-Klein, A; Le Targat, R; Lodewyck, J; Lopez, O; Pottie, P-E

2016-08-09

Leveraging the unrivalled performance of optical clocks as key tools for geo-science, for astronomy and for fundamental physics beyond the standard model requires comparing the frequency of distant optical clocks faithfully. Here, we report on the comparison and agreement of two strontium optical clocks at an uncertainty of 5 × 10(-17) via a newly established phase-coherent frequency link connecting Paris and Braunschweig using 1,415 km of telecom fibre. The remote comparison is limited only by the instability and uncertainty of the strontium lattice clocks themselves, with negligible contributions from the optical frequency transfer. A fractional precision of 3 × 10(-17) is reached after only 1,000 s averaging time, which is already 10 times better and more than four orders of magnitude faster than any previous long-distance clock comparison. The capability of performing high resolution international clock comparisons paves the way for a redefinition of the unit of time and an all-optical dissemination of the SI-second.

Electron-cyclotron maser emission during flares: emission in various modes and temporal variations

International Nuclear Information System (INIS)

Winglee, R.M.; Dulk, G.A.

1986-01-01

Absorption of radiation at the electron-cyclotron frequency, OMEGA sub e, generated by the electron-cyclotron maser instability was proposed as a possible mechanism for transporting energy and heating of the corona during flares. Radiation from the same instability but at harmonics of OMEGA sub e is believed to be the source of solar microwave spike bursts. The actual mode and frequency of the dominant emission from the maser instability is shown to be dependent on: (1) the plasma temperature, (2) the form of the energetic electron distribution, and (3) on the ratio of the plasma frequency omega sub p to OMEGA sub e. As a result, the emission along a flux tube can vary, with emission at harmonics being favored in regions where omega sub p/OMEGA sub e approx. equal to or greater than 1. Changes in the plasma density and temperature in the source region associated with the flare can also cause the characteristics of the emission to change in time

Programmable Clock Waveform Generation for CCD Readout

Energy Technology Data Exchange (ETDEWEB)

Vicente, J. de; Castilla, J.; Martinez, G.; Marin, J.

2006-07-01

Charge transfer efficiency in CCDs is closely related to the clock waveform. In this paper, an experimental framework to explore different FPGA based clock waveform generator designs is described. Two alternative design approaches for controlling the rise/fall edge times and pulse width of the CCD clock signal have been implemented: level-control and time-control. Both approaches provide similar characteristics regarding the edge linearity and noise. Nevertheless, dissimilarities have been found with respect to the area and frequency range of application. Thus, while the time-control approach consumes less area, the level control approach provides a wider range of clock frequencies since it does not suffer capacitor discharge effect. (Author) 8 refs.

Using Integer Clocks to Verify the Timing-Sync Sensor Network Protocol

Science.gov (United States)

Huang, Xiaowan; Singh, Anu; Smolka, Scott A.

2010-01-01

We use the UPPAAL model checker for Timed Automata to verify the Timing-Sync time-synchronization protocol for sensor networks (TPSN). The TPSN protocol seeks to provide network-wide synchronization of the distributed clocks in a sensor network. Clock-synchronization algorithms for sensor networks such as TPSN must be able to perform arithmetic on clock values to calculate clock drift and network propagation delays. They must be able to read the value of a local clock and assign it to another local clock. Such operations are not directly supported by the theory of Timed Automata. To overcome this formal-modeling obstacle, we augment the UPPAAL specification language with the integer clock derived type. Integer clocks, which are essentially integer variables that are periodically incremented by a global pulse generator, greatly facilitate the encoding of the operations required to synchronize clocks as in the TPSN protocol. With this integer-clock-based model of TPSN in hand, we use UPPAAL to verify that the protocol achieves network-wide time synchronization and is devoid of deadlock. We also use the UPPAAL Tracer tool to illustrate how integer clocks can be used to capture clock drift and resynchronization during protocol execution

Cryptochrome mediates light-dependent magnetosensitivity of Drosophila's circadian clock.

Directory of Open Access Journals (Sweden)

Taishi Yoshii

2009-04-01

Full Text Available Since 1960, magnetic fields have been discussed as Zeitgebers for circadian clocks, but the mechanism by which clocks perceive and process magnetic information has remained unknown. Recently, the radical-pair model involving light-activated photoreceptors as magnetic field sensors has gained considerable support, and the blue-light photoreceptor cryptochrome (CRY has been proposed as a suitable molecule to mediate such magnetosensitivity. Since CRY is expressed in the circadian clock neurons and acts as a critical photoreceptor of Drosophila's clock, we aimed to test the role of CRY in magnetosensitivity of the circadian clock. In response to light, CRY causes slowing of the clock, ultimately leading to arrhythmic behavior. We expected that in the presence of applied magnetic fields, the impact of CRY on clock rhythmicity should be altered. Furthermore, according to the radical-pair hypothesis this response should be dependent on wavelength and on the field strength applied. We tested the effect of applied static magnetic fields on the circadian clock and found that flies exposed to these fields indeed showed enhanced slowing of clock rhythms. This effect was maximal at 300 muT, and reduced at both higher and lower field strengths. Clock response to magnetic fields was present in blue light, but absent under red-light illumination, which does not activate CRY. Furthermore, cry(b and cry(OUT mutants did not show any response, and flies overexpressing CRY in the clock neurons exhibited an enhanced response to the field. We conclude that Drosophila's circadian clock is sensitive to magnetic fields and that this sensitivity depends on light activation of CRY and on the applied field strength, consistent with the radical pair mechanism. CRY is widespread throughout biological systems and has been suggested as receptor for magnetic compass orientation in migratory birds. The present data establish the circadian clock of Drosophila as a model system

NPAS2 Compensates for Loss of CLOCK in Peripheral Circadian Oscillators.

Directory of Open Access Journals (Sweden)

Dominic Landgraf

2016-02-01

Full Text Available Heterodimers of CLOCK and BMAL1 are the major transcriptional activators of the mammalian circadian clock. Because the paralog NPAS2 can substitute for CLOCK in the suprachiasmatic nucleus (SCN, the master circadian pacemaker, CLOCK-deficient mice maintain circadian rhythms in behavior and in tissues in vivo. However, when isolated from the SCN, CLOCK-deficient peripheral tissues are reportedly arrhythmic, suggesting a fundamental difference in circadian clock function between SCN and peripheral tissues. Surprisingly, however, using luminometry and single-cell bioluminescence imaging of PER2 expression, we now find that CLOCK-deficient dispersed SCN neurons and peripheral cells exhibit similarly stable, autonomous circadian rhythms in vitro. In CLOCK-deficient fibroblasts, knockdown of Npas2 leads to arrhythmicity, suggesting that NPAS2 can compensate for loss of CLOCK in peripheral cells as well as in SCN. Our data overturn the notion of an SCN-specific role for NPAS2 in the molecular circadian clock, and instead indicate that, at the cellular level, the core loops of SCN neuron and peripheral cell circadian clocks are fundamentally similar.

FUNCTIONAL IMPLICATIONS OF THE CLOCK 3111T/C SINGLE-NUCLEOTIDE POLYMORPHISM

Directory of Open Access Journals (Sweden)

Angela Renee Ozburn

2016-04-01

Full Text Available Circadian rhythm disruptions are prominently associated with Bipolar Disorder (BD. Circadian rhythms are regulated by the molecular clock, a family of proteins that function together in a transcriptional-translational feedback loop. The CLOCK protein is a key transcription factor of this feedback loop, and previous studies have found that manipulations of the Clock gene are sufficient to produce manic-like behavior in mice (Roybal et al., 2007. The Clock 3111T/C single-nucleotide polymorphism (SNP; rs1801260 is a genetic variation of the human Clock gene that is significantly associated with increased frequency of manic episodes in BD patients (Benedetti et al., 2003. The 3111T/C SNP is located in the 3’ untranslated region of the Clock gene. In this study, we sought to examine the functional implications of the human Clock 3111T/C SNP by transfecting a mammalian cell line (mouse embryonic fibroblasts isolated from Clock -/- knockout mice with pcDNA plasmids containing the human Clock gene with either the T or C SNP at position 3111. We then measured circadian gene expression over a 24 hour time period. We found that the Clock3111C SNP resulted in higher mRNA levels than the Clock 3111T SNP. Further, we found that Per2, a transcriptional target of CLOCK, was also more highly expressed with Clock 3111C expression, indicating the 3’UTR SNP affects the expression, function and stability of Clock mRNA.

Fast Clock Recovery for Digital Communications

Science.gov (United States)

Tell, R. G.

1985-01-01

Circuit extracts clock signal from random non-return-to-zero data stream, locking onto clock within one bit period at 1-gigabitper-second data rate. Circuit used for synchronization in opticalfiber communications. Derives speed from very short response time of gallium arsenide metal/semiconductor field-effect transistors (MESFET's).

The transcriptome of the human mast cell leukemia cells HMC-1.2: an approach to identify specific changes in the gene expression profile in KitD816V systemic mastocytosis.

Science.gov (United States)

Haenisch, B; Herms, S; Molderings, G J

2013-05-01

To circumvent the costly isolation procedure associated with tissue mast cells, human mast cell lines such as HMC-1 are employed in mastocytosis research, but their relation to mutated mast cells in systemic mastocytosis has not been investigated systematically. In the present study, we determined the transcriptome of HMC-1.2 cells and compared the expression data with those reported in the literature for normal human resting lung and tonsillar mast cells as well as leukocytes from peripheral blood and mononuclear cells from bone marrow aspirates of patients with D816 V-positive systemic mastocytosis. Our results suggest that HMC-1.2 cells are an appropriate model for the investigation of this variant of systemic mast cell activation disease. The data confirm previous suggestions that the pathologically increased activity of mast cells in patients with D816 V-positive systemic mastocytosis can be deduced from the detection of mutation-related changes in the gene expression profile in leukocytes from peripheral blood and in mononuclear cells from bone marrow aspirates. Thus, mutation-related changes of the expression profile can serve as surrogates (besides clustering of mast cells, expression of CD25, and increased release of tryptase) for the presence of the mutation D816 V in tyrosine kinase Kit in patients with systemic mastocytosis according to the WHO criteria. Whether this also holds true for systemic mast cell activation disease caused by other mutations in Kit or other mast cell activity-related genes is a subject for future studies.

Do Caucasian and Asian clocks tick differently?

Directory of Open Access Journals (Sweden)

A.A. Barbosa

Full Text Available The Period 3 and Clock genes are important components of the mammalian molecular circadian system. Studies have shown association between polymorphisms in these clock genes and circadian phenotypes in different populations. Nevertheless, differences in the pattern of allele frequency and genotyping distribution are systematically observed in studies with different ethnic groups. To investigate and compare the pattern of distribution in a sample of Asian and Caucasian populations living in Brazil, we evaluated two well-studied polymorphisms in the clock genes: a variable number of tandem repeats (VNTR in PER3 and a single nucleotide polymorphism (SNP in CLOCK. The aim of this investigation was to search for clues about human evolutionary processes related to circadian rhythms. We selected 109 Asian and 135 Caucasian descendants. The frequencies of the shorter allele (4 repeats in the PER3 gene and the T allele in the CLOCK gene among Asians (0.86 and 0.84, respectively were significantly higher than among Caucasians (0.69 and 0.71, respectively. Our results directly confirmed the different distribution of these polymorphisms between the Asian and Caucasian ethnic groups. Given the genetic differences found between groups, two points became evident: first, ethnic variations may have implications for the interpretation of results in circadian rhythm association studies, and second, the question may be raised about which evolutionary conditions shaped these genetic clock variations.

Transmission delays in hardware clock synchronization

Science.gov (United States)

Shin, Kang G.; Ramanathan, P.

1988-01-01

Various methods, both with software and hardware, have been proposed to synchronize a set of physical clocks in a system. Software methods are very flexible and economical but suffer an excessive time overhead, whereas hardware methods require no time overhead but are unable to handle transmission delays in clock signals. The effects of nonzero transmission delays in synchronization have been studied extensively in the communication area in the absence of malicious or Byzantine faults. The authors show that it is easy to incorporate the ideas from the communication area into the existing hardware clock synchronization algorithms to take into account the presence of both malicious faults and nonzero transmission delays.

Comparisons of mental clocks.

Science.gov (United States)

Paivio, A

1978-02-01

Subjects in three experiments were presented with pairs of clock times and were required to choose the one in which the hour and minute hand formed the smaller angle. In Experiments 1 and 2, the times were presented digitally, necessitating a transformation into symbolic representations from which the angular size difference could be inferred. The results revealed orderly symbolic distance effects so that comparison reaction time increased as the angular size difference decreased. Moreover, subjects generally reported using imagery to make the judgment, and subjects scoring high on test of imagery ability were faster than those scoring low on such tests. Experiment 3 added a direct perceptual condition in which subjects compared angles between pairs of hands on two drawn (analog) clocks, as well as a mixed condition involving one digital and one analog clock time. The results showed comparable distance effects for all conditions. In addition, reaction time increased from the perceptual, to the mixed, to the pure-digital condition. These results are consistent with predictions from an image-based dual-coding theory.

A New Trapped Ion Clock Based on Hg-201(+)

Science.gov (United States)

Taghavi-Larigani, S.; Burt, E. A.; Lea, S. N.; Prestage, J. D.; Tjoelker, R. L.

2009-01-01

There are two stable odd isotopes of mercury with singly ionized hyperfine structure suitable for a microwave clock: Hg-199(+) and Hg-201(+). Virtually all trapped mercury ion clocks to date have used the 199 isotope. We have begun to investigate the viability of a trapped ion clock based on Hg-201(+). We have measured the unperturbed frequency of the (S-2)(sub 1/2) F = 1, m(sub F) = 0 to (S-2)(sub 1/2) F = 2, m(sub F) = 0 clock transition to be 29.9543658211(2) GHz. In this paper we describe initial measurements with Hg-201(+) and new applications to clocks and fundamental physics.

Physics 1963-1970

CERN Document Server

Zhou, Yong

2013-01-01

Physics: 1963-1970 focuses on the history, developments, and trends in physics, including the applications of lasers, semiconductors, and electrodynamics. The book first offers information on events, laws of nature, and invariance principles and the shell model. Topics include magic numbers, atomic analogue, individual orbits in the nucleus, and the use of invariance principles and approximate invariances. The text also ponders on the production of coherent radiation by atoms and molecules, including basic maser principles, maser clocks and amplifiers, and application of lasers. The

Evidence for widespread dysregulation of circadian clock progression in human cancer

Directory of Open Access Journals (Sweden)

Jarrod Shilts

2018-01-01

Full Text Available The ubiquitous daily rhythms in mammalian physiology are guided by progression of the circadian clock. In mice, systemic disruption of the clock can promote tumor growth. In vitro, multiple oncogenes can disrupt the clock. However, due to the difficulties of studying circadian rhythms in solid tissues in humans, whether the clock is disrupted within human tumors has remained unknown. We sought to determine the state of the circadian clock in human cancer using publicly available transcriptome data. We developed a method, called the clock correlation distance (CCD, to infer circadian clock progression in a group of samples based on the co-expression of 12 clock genes. Our method can be applied to modestly sized datasets in which samples are not labeled with time of day and coverage of the circadian cycle is incomplete. We used the method to define a signature of clock gene co-expression in healthy mouse organs, then validated the signature in healthy human tissues. By then comparing human tumor and non-tumor samples from twenty datasets of a range of cancer types, we discovered that clock gene co-expression in tumors is consistently perturbed. Subsequent analysis of data from clock gene knockouts in mice suggested that perturbed clock gene co-expression in human cancer is not caused solely by the inactivation of clock genes. Furthermore, focusing on lung cancer, we found that human lung tumors showed systematic changes in expression in a large set of genes previously inferred to be rhythmic in healthy lung. Our findings suggest that clock progression is dysregulated in many solid human cancers and that this dysregulation could have broad effects on circadian physiology within tumors. In addition, our approach opens the door to using publicly available data to infer circadian clock progression in a multitude of human phenotypes.

Vane clocking effects in an embedded compressor stage

Science.gov (United States)

Key, Nicole Leanne

The objective of this research was to experimentally investigate the effects of vane clocking, the circumferential indexing of adjacent vane rows with similar vane counts, in an embedded compressor stage. Experiments were performed in the Purdue 3-Stage Compressor, which consists of an IGV followed by three stages. The IGV, Stator 1, and Stator 2 have identical vane counts of 44, and the effects of clocking were studied on Stage 2. The clocking configuration that located the upstream vane wake on the Stator 2 leading edge was identified with total pressure measurements at the inlet to Stator 2 and confirmed with measurements at the exit of Stator 2. For both loading conditions, the total temperature results showed that there was no measurable change associated with vane clocking in the amount of work done on the flow. At design loading, the change in stage efficiency with vane clocking was 0.27 points between the maximum and minimum efficiency clocking configurations. The maximum efficiency configuration was the case where the Stator 1 wake impinged on the Stator 2 leading edge. This condition produced a shallower and thinner Stator 2 wake compared to the clocking configuration that located the wake in the middle of the Stator 2 passage. By locating the Stator 1 wake at the leading edge, it dampened the Stator 2 boundary layer response to inlet fluctuations associated with the Rotor 2 wakes. At high loading, the change in Stage 2 efficiency increased to 1.07 points; however, the maximum efficiency clocking configuration was the case where the Stator 1 wake passed through the middle of the downstream vane passage. At high loading, the flow physics associated with vane clocking were different than at design loading because the location of the Stator 1 wake fluid on the Stator 2 leading edge triggered a boundary layer separation on the suction side of Stator 2 producing a wider and deeper wake. Vane clocking essentially affects the amount of interaction between the

Math Clock: Perangkat Penunjuk Waktu Kreatif untuk Olahraga Otak

Directory of Open Access Journals (Sweden)

Galuh Boy Hertantyo

2014-11-01

Full Text Available Brain is one of the most vital parts for humans, with the number of brain function that is needed for the body, the brain becomes a very important part of the human body. If there is damage to the brain will certainly cause the performance of the human body will not run properly. Because of that, it’s very important to maintain brain health. There is a way to maintain brain health, for example is by doing brain exercise. Examples of brain exercise is to do simple math calculations or doing brain games like sudoku. Because of that, created a tool that can help the brain to maintain brain exercise. The tool is called math clock. Making math clock tool consists of hardware and software. The hardware consists of RTC as real time data input, ATmega328 as microcontroller and dot matrix 32x16 as a tool to display the output that has been processed by the microcontroller. The software is built using C with Arduino IDE. Math clock will process the data from RTC then processed it, in microcontroller so when output displayed on dot matrix, output will be simple mathematical operation with real time clock data on it. Test results show that, math clock is capable of displaying a simple mathematical calculation operations such as addition, subtraction, multiplication and division. The mathematical operation that display on math clock, appears to be random, so it’s not triggered by same mathematical operation. In math clock the display will change every 20 second, so in 1 minute there are 3 different kinds of mathematical operations. The results of questionnaires of 10 different students, showed 9 out of 10 students said math clock is a tool that easy to use as a clock. Math clock will be alternative for doing brain exercise every day.

Electromagnetic synchronisation of clocks with finite separation in a rotating system

International Nuclear Information System (INIS)

Cohen, J.M.; Moses, H.E.; Rosenblum, A.; Temple Univ., Philadelphia, PA

1984-01-01

For clocks on the vertices of a triangle, it is shown that clock synchronisation using electromagnetic signals between finitely spaced clocks in a rotating frame leads to the same synchronisation error as a closely spaced band of clocks along the same light path. In addition, the above result is generalised to n equally spaced clocks. (author)

Synthesizing genetic sequential logic circuit with clock pulse generator.

Science.gov (United States)

Chuang, Chia-Hua; Lin, Chun-Liang

2014-05-28

Rhythmic clock widely occurs in biological systems which controls several aspects of cell physiology. For the different cell types, it is supplied with various rhythmic frequencies. How to synthesize a specific clock signal is a preliminary but a necessary step to further development of a biological computer in the future. This paper presents a genetic sequential logic circuit with a clock pulse generator based on a synthesized genetic oscillator, which generates a consecutive clock signal whose frequency is an inverse integer multiple to that of the genetic oscillator. An analogous electronic waveform-shaping circuit is constructed by a series of genetic buffers to shape logic high/low levels of an oscillation input in a basic sinusoidal cycle and generate a pulse-width-modulated (PWM) output with various duty cycles. By controlling the threshold level of the genetic buffer, a genetic clock pulse signal with its frequency consistent to the genetic oscillator is synthesized. A synchronous genetic counter circuit based on the topology of the digital sequential logic circuit is triggered by the clock pulse to synthesize the clock signal with an inverse multiple frequency to the genetic oscillator. The function acts like a frequency divider in electronic circuits which plays a key role in the sequential logic circuit with specific operational frequency. A cascaded genetic logic circuit generating clock pulse signals is proposed. Based on analogous implement of digital sequential logic circuits, genetic sequential logic circuits can be constructed by the proposed approach to generate various clock signals from an oscillation signal.

Lattice-induced nonadiabatic frequency shifts in optical lattice clocks

International Nuclear Information System (INIS)

Beloy, K.

2010-01-01

We consider the frequency shift in optical lattice clocks which arises from the coupling of the electronic motion to the atomic motion within the lattice. For the simplest of three-dimensional lattice geometries this coupling is shown to affect only clocks based on blue-detuned lattices. We have estimated the size of this shift for the prospective strontium lattice clock operating at the 390-nm blue-detuned magic wavelength. The resulting fractional frequency shift is found to be on the order of 10 -18 and is largely overshadowed by the electric quadrupole shift. For lattice clocks based on more complex geometries or other atomic systems, this shift could potentially be a limiting factor in clock accuracy.

Improvement of an Atomic Clock using Squeezed Vacuum

DEFF Research Database (Denmark)

Kruse, I.; Lange, K; Peise, Jan

2016-01-01

, the vacuum noise restricts the precision of the interferometer to the standard quantum limit (SQL). Here, we propose and experimentally demonstrate a novel clock configuration that surpasses the SQL by squeezing the vacuum in the empty input state. We create a squeezed vacuum state containing an average of 0.......75 atoms to improve the clock sensitivity of 10000 atoms by 2.05+0.34−0.37  dB. The SQL poses a significant limitation for today’s microwave fountain clocks, which serve as the main time reference. We evaluate the major technical limitations and challenges for devising a next generation of fountain clocks...

The mammalian retina as a clock

Science.gov (United States)

Tosini, Gianluca; Fukuhara, Chiaki

2002-01-01

Many physiological, cellular, and biochemical parameters in the retina of vertebrates show daily rhythms that, in many cases, also persist under constant conditions. This demonstrates that they are driven by a circadian pacemaker. The presence of an autonomous circadian clock in the retina of vertebrates was first demonstrated in Xenopus laevis and then, several years later, in mammals. In X. laevis and in chicken, the retinal circadian pacemaker has been localized in the photoreceptor layer, whereas in mammals, such information is not yet available. Recent advances in molecular techniques have led to the identification of a group of genes that are believed to constitute the molecular core of the circadian clock. These genes are expressed in the retina, although with a slightly different 24-h profile from that observed in the central circadian pacemaker. This result suggests that some difference (at the molecular level) may exist between the retinal clock and the clock located in the suprachiasmatic nuclei of hypothalamus. The present review will focus on the current knowledge of the retinal rhythmicity and the mechanisms responsible for its control.

Ferrite-guided cyclotron-resonance maser

International Nuclear Information System (INIS)

Jerby, Eli; Kesar, A.; Aharony, A.; Breitmeier, G.

2002-01-01

The concept of a cyclotron-resonance maser (CRM) with a ferrite loading incorporated in its waveguide is proposed. The CRM interaction occurs between the rotating electron beam and the em wave propagating along a longitudinally magnetized ferrite medium. The ferrite anisotropic permeability resembles the CRM susceptibility in many aspects, and particularly in their similar response to the axial magnetic field (the ferrite susceptibility can be regarded as a passive analog of the active CRM interaction). The ferrite loading slows down the phase velocity of the em wave and thus the axial (Weibel) mechanism of the CRM interaction dominates. The ferrite loading enables also a mechanism of spectral tunability for CRM's. The ferrite loading is proposed, therefore, as a useful ingredient for high-power CRM devices. A linear model of the combined ferrite-guided CRM interaction reveals its useful features. Future schemes may also incorporate ferrite sections functioning as isolators, gyrators, or phase shifters within the CRM device itself for selective suppression of backward waves and spurious oscillations, and for gain and efficiency enhancement

Explaining recurring maser flares in the ISM through large-scale entangled quantum mechanical states.

Science.gov (United States)

Rajabi, Fereshteh; Houde, Martin

2017-03-01

We apply Dicke's theory of superradiance (introduced in 1954) to the 6.7-GHz methanol and 22-GHz water spectral lines, often detected in molecular clouds as signposts for the early stages of the star formation process. We suggest that superradiance, characterized by burst-like features taking place over a wide range of time scales, may provide a natural explanation for the recent observations of periodic and seemingly alternating methanol and water maser flares in G107.298+5.639. Although these observations would be very difficult to explain within the context of maser theory, we show that these flares may result from simultaneously initiated 6.7-GHz methanol and 22-GHz water superradiant bursts operating on different time scales, thus providing a natural mechanism for their observed durations and time ordering. The evidence of superradiance in this source further suggests the existence of entangled quantum mechanical states, involving a very large number of molecules, over distances of up to a few kilometers in the interstellar medium.

A high-precision synchronization circuit for clock distribution

International Nuclear Information System (INIS)

Lu Chong; Tan Hongzhou; Duan Zhikui; Ding Yi

2015-01-01

In this paper, a novel structure of a high-precision synchronization circuit, HPSC, using interleaved delay units and a dynamic compensation circuit is proposed. HPSCs are designed for synchronization of clock distribution networks in large-scale integrated circuits, where high-quality clocks are required. The application of a hybrid structure of a coarse delay line and dynamic compensation circuit performs roughly the alignment of the clock signal in two clock cycles, and finishes the fine tuning in the next three clock cycles with the phase error suppressed under 3.8 ps. The proposed circuit is implemented and fabricated using a SMIC 0.13 μm 1P6M process with a supply voltage at 1.2 V. The allowed operation frequency ranges from 200 to 800 MHz, and the duty cycle ranges between [20%, 80%]. The active area of the core circuits is 245 × 134 μm 2 , and the power consumption is 1.64 mW at 500 MHz. (paper)

[Elevated expression of CLOCK is associated with poor prognosis in hepatocellular carcinoma].

Science.gov (United States)

Li, Bo; Yang, Xiliang; Li, Jiaqi; Yang, Yi; Yan, Zhaoyong; Zhang, Hongxin; Mu, Jiao

2018-02-01

Objective To evaluate the expression of circadian locomotor output cycles kaput (CLOCK) and its effects on cell growth in hepatocellular carcinoma (HCC). Methods The expression of CLOCK in 158 pairs of human HCC tissues and matched noncancerous samples was detected by immunohistochemical (IHC) staining. The expression of CLOCK in HCC patients was also verified using the data from GEO and TCGA (a total of 356 cases). The relationship between CLOCK expression and clinicopathological features of HCC patients was analyzed by single factor statistical analysis. Kaplan-Meier survival curves of HCC patients were drawn to study the relationship between the expression level of CLOCK and the survival state. The effect of CLOCK on the growth of HepG2 cells was detected by MTS assay. Results The expression of CLOCK in HCC tissues was significantly higher than that in the adjacent tissues, and the up-regulation of CLOCK expression in HCC tissue was also confirmed in the public data of HCC (356 cases). HCC patients were divided into low CLOCK expression group and high CLOCK expression group. Univariate analysis showed that the expression of CLOCK was related to tumor size, TNM stage, and portal vein invasion in HCC patients. HCC patients with low CLOCK expression had longer overall survival time and relapse-free survival time than those with high CLOCK expression. The proliferation of cells significantly decreased after the expression of CLOCK was knocked down in HepG2 cells. Conclusion The expression of CLOCK in HCC tissues was much higher than that in normal liver tissues, and the high expression of CLOCK indicated the poor prognosis. The knockdown of CLOCK in HCC cells could inhibit the proliferation of HepG2 cells.

A clock synchronization skeleton based on RTAI

NARCIS (Netherlands)

Huang, Y.; Visser, P.M.; Broenink, Johannes F.

2006-01-01

This paper presents a clock synchronization skeleton based on RTAI (Real Time Application Interface). The skeleton is a thin layer that provides unified but extendible interfaces to the underlying operating system, the synchronization algorithms and the upper level applications in need of clock

Shining a light on the Arabidopsis circadian clock.

Science.gov (United States)

Oakenfull, Rachael J; Davis, Seth J

2017-11-01

The circadian clock provides essential timing information to ensure optimal growth to prevailing external environmental conditions. A major time-setting mechanism (zeitgeber) in clock synchronization is light. Differing light wavelengths, intensities, and photoperiodic duration are processed for the clock-setting mechanism. Many studies on light-input pathways to the clock have focused on Arabidopsis thaliana. Photoreceptors are specific chromic proteins that detect light signals and transmit this information to the central circadian oscillator through a number of different signalling mechanisms. The most well-characterized clock-mediating photoreceptors are cryptochromes and phytochromes, detecting blue, red, and far-red wavelengths of light. Ultraviolet and shaded light are also processed signals to the oscillator. Notably, the clock reciprocally generates rhythms of photoreceptor action leading to so-called gating of light responses. Intermediate proteins, such as Phytochrome interacting factors (PIFs), constitutive photomorphogenic 1 (COP1) and EARLY FLOWERING 3 (ELF3), have been established in signalling pathways downstream of photoreceptor activation. However, the precise details for these signalling mechanisms are not fully established. This review highlights both historical and recent efforts made to understand overall light input to the oscillator, first looking at how each wavelength of light is detected, this is then related to known input mechanisms and their interactions. © 2017 John Wiley & Sons Ltd.

Time without clocks - an attempt

International Nuclear Information System (INIS)

Karpman, G.

1978-01-01

A definition of time intervals separating two states of systems of elementary particles and observers is attempted. The definition is founded on the notion of instant state of the system and uses no information connected with the use of a clock. Applying the definition to a classical clock and to a sample of unstable particles, results are obtained in agreement with experiment. However, if the system contains 'few' elementary particles, the properties of the time interval present some different features. (author)

The Mechanics of Mechanical Watches and Clocks

CERN Document Server

Du, Ruxu

2013-01-01

"The Mechanics of Mechanical Watches and Clocks" presents historical views and mathematical models of mechanical watches and clocks. Although now over six hundred years old, mechanical watches and clocks are still popular luxury items that fascinate many people around the world. However few have examined the theory of how they work as presented in this book. The illustrations and computer animations are unique and have never been published before. It will be of significant interest to researchers in mechanical engineering, watchmakers and clockmakers, as well as people who have an engineering background and are interested in mechanical watches and clocks. It will also inspire people in other fields of science and technology, such as mechanical engineering and electronics engineering, to advance their designs. Professor Ruxu Du works at the Chinese University of Hong Kong, China. Assistant Professor Longhan Xie works at the South China University of Technology, China.

The mammalian circadian clock and its entrainment by stress and exercise.

Science.gov (United States)

Tahara, Yu; Aoyama, Shinya; Shibata, Shigenobu

2017-01-01

The mammalian circadian clock regulates day-night fluctuations in various physiological processes. The circadian clock consists of the central clock in the suprachiasmatic nucleus of the hypothalamus and peripheral clocks in peripheral tissues. External environmental cues, including light/dark cycles, food intake, stress, and exercise, provide important information for adjusting clock phases. This review focuses on stress and exercise as potent entrainment signals for both central and peripheral clocks, especially in regard to the timing of stimuli, types of stressors/exercises, and differences in the responses of rodents and humans. We suggest that the common signaling pathways of clock entrainment by stress and exercise involve sympathetic nervous activation and glucocorticoid release. Furthermore, we demonstrate that physiological responses to stress and exercise depend on time of day. Therefore, using exercise to maintain the circadian clock at an appropriate phase and amplitude might be effective for preventing obesity, diabetes, and cardiovascular disease.

A quantum mechanical approach to establishing the magnetic field orientation from a maser Zeeman profile

Science.gov (United States)

Green, J. A.; Gray, M. D.; Robishaw, T.; Caswell, J. L.; McClure-Griffiths, N. M.

2014-06-01

Recent comparisons of magnetic field directions derived from maser Zeeman splitting with those derived from continuum source rotation measures have prompted new analysis of the propagation of the Zeeman split components, and the inferred field orientation. In order to do this, we first review differing electric field polarization conventions used in past studies. With these clearly and consistently defined, we then show that for a given Zeeman splitting spectrum, the magnetic field direction is fully determined and predictable on theoretical grounds: when a magnetic field is oriented away from the observer, the left-hand circular polarization is observed at higher frequency and the right-hand polarization at lower frequency. This is consistent with classical Lorentzian derivations. The consequent interpretation of recent measurements then raises the possibility of a reversal between the large-scale field (traced by rotation measures) and the small-scale field (traced by maser Zeeman splitting).

Precision Clock Evaluation Facility

Data.gov (United States)

Federal Laboratory Consortium — FUNCTION: Tests and evaluates high-precision atomic clocks for spacecraft, ground, and mobile applications. Supports performance evaluation, environmental testing,...

The clock paradox as a cosmological problem

International Nuclear Information System (INIS)

Fu, K.Y.

1975-01-01

In this paper the clock paradox is discussed within the framework of the general theory of relativity. It is shown that in general the aging asymmetry exists. It is also argued that the clock paradox, according to Mach's principle, is essentially a cosmological problem. (author)

Molecular Mechanisms Regulating Temperature Compensation of the Circadian Clock.

Science.gov (United States)

Narasimamurthy, Rajesh; Virshup, David M

2017-01-01

An approximately 24-h biological timekeeping mechanism called the circadian clock is present in virtually all light-sensitive organisms from cyanobacteria to humans. The clock system regulates our sleep-wake cycle, feeding-fasting, hormonal secretion, body temperature, and many other physiological functions. Signals from the master circadian oscillator entrain peripheral clocks using a variety of neural and hormonal signals. Even centrally controlled internal temperature fluctuations can entrain the peripheral circadian clocks. But, unlike other chemical reactions, the output of the clock system remains nearly constant with fluctuations in ambient temperature, a phenomenon known as temperature compensation. In this brief review, we focus on recent advances in our understanding of the posttranslational modifications, especially a phosphoswitch mechanism controlling the stability of PER2 and its implications for the regulation of temperature compensation.

Molecular Mechanisms Regulating Temperature Compensation of the Circadian Clock

Directory of Open Access Journals (Sweden)

David M. Virshup

2017-04-01

Full Text Available An approximately 24-h biological timekeeping mechanism called the circadian clock is present in virtually all light-sensitive organisms from cyanobacteria to humans. The clock system regulates our sleep–wake cycle, feeding–fasting, hormonal secretion, body temperature, and many other physiological functions. Signals from the master circadian oscillator entrain peripheral clocks using a variety of neural and hormonal signals. Even centrally controlled internal temperature fluctuations can entrain the peripheral circadian clocks. But, unlike other chemical reactions, the output of the clock system remains nearly constant with fluctuations in ambient temperature, a phenomenon known as temperature compensation. In this brief review, we focus on recent advances in our understanding of the posttranslational modifications, especially a phosphoswitch mechanism controlling the stability of PER2 and its implications for the regulation of temperature compensation.

Time variations of stellar water masers

International Nuclear Information System (INIS)

Cox, G.G.; Parker, E.A.

1979-01-01

The 22-GHz H 2 O spectra of the stars RS Vir, RT Vir, R Aql, W Hya, U Her, S Cr B, Rx Boo, R Crt and VY CMa have been observed at intervals during the period 1974 September -1977 May. Optical and infrared measurements have also been made. New components have been observed in the H 2 O spectra of most of the stars, and the flux density of W Hya reached 2000 Jy near Jd 2442700. The intensities of the three main groups of components in VY CMa varied in phase consistent with a central pump source. In several stars the intensities were very different from those found by earlier observers, showing that stellar H 2 O masers are often not stable for more than a few cycles of the stellar luminosity. For part of the time the H 2 O and infrared intensities of R Aql and RS Vir were anticorrelated. (author)

The Molecular Circadian Clock and Alcohol-Induced Liver Injury

Directory of Open Access Journals (Sweden)

Uduak S. Udoh

2015-10-01

Full Text Available Emerging evidence from both experimental animal studies and clinical human investigations demonstrates strong connections among circadian processes, alcohol use, and alcohol-induced tissue injury. Components of the circadian clock have been shown to influence the pathophysiological effects of alcohol. Conversely, alcohol may alter the expression of circadian clock genes and the rhythmic behavioral and metabolic processes they regulate. Therefore, we propose that alcohol-mediated disruption in circadian rhythms likely underpins many adverse health effects of alcohol that cut across multiple organ systems. In this review, we provide an overview of the circadian clock mechanism and showcase results from new studies in the alcohol field implicating the circadian clock as a key target of alcohol action and toxicity in the liver. We discuss various molecular events through which alcohol may work to negatively impact circadian clock-mediated processes in the liver, and contribute to tissue pathology. Illuminating the mechanistic connections between the circadian clock and alcohol will be critical to the development of new preventative and pharmacological treatments for alcohol use disorders and alcohol-mediated organ diseases.

Clocks do not tick in unison: isolation of Clock and vrille shed new light on the clockwork model of the sand fly Lutzomyia longipalpis.

Science.gov (United States)

Gesto, João Silveira Moledo; Rivas, Gustavo Bueno da Silva; Pavan, Marcio Galvão; Meireles-Filho, Antonio Carlos Alves; Amoretty, Paulo Roberto de; Souza, Nataly Araújo de; Bruno, Rafaela Vieira; Peixoto, Alexandre Afranio

2015-10-06

Behavior rhythms of insect vectors directly interfere with the dynamics of pathogen transmission to humans. The sand fly Lutzomyia longipalpis is the main vector of visceral leishmaniasis in America and concentrates its activity around dusk. Despite the accumulation of behavioral data, very little is known about the molecular bases of the clock mechanism in this species. This study aims to characterize, within an evolutionary perspective, two important circadian clock genes, Clock and vrille. We have cloned and isolated the coding sequence of L. longipalpis' genes Clock and vrille. The former is structured in eight exons and encodes a protein of 696 amino acids, and the latter comprises three exons and translates to a protein of 469 amino acids. When compared to other insects' orthologues, L. longipalpis CLOCK shows a high degree of conservation in the functional domains bHLH and PAS, but a much shorter glutamine-rich (poly-Q) C-terminal region. As for L. longipalpis VRILLE, a high degree of conservation was found in the bZIP domain. To support these observations and provide an elegant view of the evolution of both genes in insects, phylogenetic analyses based on maximum-likelihood and Bayesian inferences were performed, corroborating the previously known insect systematics. The isolation and phylogenetic analyses of Clock and vrille orthologues in L. longipalpis bring novel and important data to characterize this species' circadian clock. Interestingly, the poly-Q shortening observed in CLOCK suggests that its transcription activity might be impaired and we speculate if this effect could be compensated by other clock factors such as CYCLE.

Reduced Kalman Filters for Clock Ensembles

Science.gov (United States)

Greenhall, Charles A.

2011-01-01

This paper summarizes the author's work ontimescales based on Kalman filters that act upon the clock comparisons. The natural Kalman timescale algorithm tends to optimize long-term timescale stability at the expense of short-term stability. By subjecting each post-measurement error covariance matrix to a non-transparent reduction operation, one obtains corrected clocks with improved short-term stability and little sacrifice of long-term stability.

The role of biological clock in glucose homeostasis 

Directory of Open Access Journals (Sweden)

Piotr Chrościcki

2013-06-01

Full Text Available The mechanism of the biological clock is based on a rhythmic expression of clock genes and clock-controlled genes. As a result of their transcripto-translational associations, endogenous rhythms in the synthesis of key proteins of various physiological and metabolic processes are created. The major timekeeping mechanism for these rhythms exists in the central nervous system. The master circadian clock, localized in suprachiasmatic nucleus (SCN, regulates multiple metabolic pathways, while feeding behavior and metabolite availability can in turn regulate the circadian clock. It is also suggested that in the brain there is a food entrainable oscillator (FEO or oscillators, resulting in activation of both food anticipatory activity and hormone secretion that control digestion processes. Moreover, most cells and tissues express autonomous clocks. Maintenance of the glucose homeostasis is particularly important for the proper function of the body, as this sugar is the main source of energy for the brain, retina, erythrocytes and skeletal muscles. Thus, glucose production and utilization are synchronized in time. The hypothalamic excited orexin neurons control energy balance of organism and modulate the glucose production and utilization. Deficiency of orexin action results in narcolepsy and weight gain, whereas glucose and amino acids can affect activity of the orexin cells. Large-scale genetic studies in rodents and humans provide evidence for the involvement of disrupted clock gene expression rhythms in the pathogenesis of obesity and type 2 diabetes. In general, the current lifestyle of the developed modern societies disturbs the action of biological clock. 

Clock face drawing test performance in children with ADHD.

Science.gov (United States)

Ghanizadeh, Ahmad; Safavi, Salar; Berk, Michael

2013-01-01

The utility and discriminatory pattern of the clock face drawing test in ADHD is unclear. This study therefore compared Clock Face Drawing test performance in children with ADHD and controls. 95 school children with ADHD and 191 other children were matched for gender ratio and age. ADHD symptoms severities were assessed using DSM-IV ADHD checklist and their intellectual functioning was assessed. The participants completed three clock-drawing tasks, and the following four functions were assessed: Contour score, Numbers score, Hands setting score, and Center score. All the subscales scores of the three clock drawing tests of the ADHD group were lower than that of the control group. In ADHD children, inattention and hyperactivity/ impulsivity scores were not related to free drawn clock test scores. When pre-drawn contour test was performed, inattentiveness score was statistically associated with Number score while none of the other variables of age, gender, intellectual functioning, and hand use preference were associated with that kind of score. In pre-drawn clock, no association of ADHD symptoms with any CDT subscales found significant. In addition, more errors are observed with free drawn clock and Pre-drawn contour than pre-drawn clock. Putting Numbers and Hands setting are more sensitive measures to screen ADHD than Contour and Center drawing. Test performance, except Hands setting, may have already reached a developmental plateau. It is probable that Hand setting deficit in children with ADHD may not decrease from age 8 to 14 years. Performance of children with ADHD is associated with complexity of CDT.

EXTREMELY BROAD RADIO RECOMBINATION MASER LINES TOWARD THE HIGH-VELOCITY IONIZED JET IN CEPHEUS A HW2

International Nuclear Information System (INIS)

Jimenez-Serra, I.; Patel, N.; Martin-Pintado, J.; Baez-Rubio, A.; Thum, C.

2011-01-01

We present the first detection of the H40α, H34α, and H31α radio recombination lines (RRLs) at millimeter wavelengths toward the high-velocity ionized jet in the Cepheus A HW2 star-forming region. From our single-dish and interferometric observations, we find that the measured RRLs show extremely broad asymmetric line profiles with zero-intensity line widths of ∼1100 km s -1 . From the line widths, we estimate a terminal velocity for the ionized gas in the jet of ≥500 km s -1 , consistent with that obtained from the proper motions of the HW2 radio jet. The total integrated line-to-continuum flux ratios of the H40α, H34α, and H31α lines are 43, 229, and 280 km s -1 , clearly deviating from LTE predictions. These ratios are very similar to those observed for the RRL masers toward MWC349A, suggesting that the intensities of the RRLs toward HW2 are affected by maser emission. Our radiative transfer modeling of the RRLs shows that their asymmetric profiles could be explained by maser emission arising from a bi-conical radio jet with a semi-opening angle of 18 deg., electron density distribution varying as r -2.11 , and turbulent and expanding wind velocities of 60 and 500 km s -1 .

Neurogenetics of Drosophila circadian clock: expect the unexpected.

Science.gov (United States)

Jarabo, Patricia; Martin, Francisco A

2017-12-01

Daily biological rhythms (i.e. circadian) are a fundamental part of animal behavior. Numerous reports have shown disruptions of the biological clock in neurodegenerative disorders and cancer. In the latter case, only recently we have gained insight into the molecular mechanisms. After 45 years of intense study of the circadian rhtythms, we find surprising similarities among species on the molecular clock that governs biological rhythms. Indeed, Drosophila is one of the most widely used models in the study of chronobiology. Recent studies in the fruit fly have revealed unpredicted roles for the clock machinery in different aspects of behavior and physiology. Not only the central pacemaker cells do have non-classical circadian functions but also circadian genes work in other cells and tissues different from central clock neurons. In this review, we summarize these new evidences. We also recapitulate the most basic features of Drosophila circadian clock, including recent data about the inputs and outputs that connect the central pacemaker with other regions of the brain. Finally, we discuss the advantages and drawbacks of using natural versus laboratory conditions.

Circadian clock components in the rat neocortex

DEFF Research Database (Denmark)

Rath, Martin Fredensborg; Rohde, Kristian; Fahrenkrug, Jan

2013-01-01

in the rat neocortex. Among these, Per1, Per2, Per3, Cry1, Bmal1, Nr1d1 and Dbp were found to exhibit daily rhythms. The amplitude of circadian oscillation in neocortical clock gene expression was damped and the peak delayed as compared with the SCN. Lesions of the SCN revealed that rhythmic clock gene...... expression in the neocortex is dependent on the SCN. In situ hybridization and immunohistochemistry showed that products of the canonical clock gene Per2 are located in perikarya throughout all areas of the neocortex. These findings show that local circadian oscillators driven by the SCN reside within...... neurons of the neocortex....

Initial atomic coherences and Ramsey frequency pulling in fountain clocks

Science.gov (United States)

Gerginov, Vladislav; Nemitz, Nils; Weyers, Stefan

2014-09-01

In the uncertainty budget of primary atomic cesium fountain clocks, evaluations of frequency-pulling shifts of the hyperfine clock transition caused by unintentional excitation of its nearby transitions (Rabi and Ramsey pulling) have been based so far on an approach developed for cesium beam clocks. We re-evaluate this type of frequency pulling in fountain clocks and pay particular attention to the effect of initial coherent atomic states. We find significantly enhanced frequency shifts caused by Ramsey pulling due to sublevel population imbalance and corresponding coherences within the state-selected hyperfine component of the initial atom ground state. Such shifts are experimentally investigated in an atomic fountain clock and quantitative agreement with the predictions of the model is demonstrated.

Clock Face Drawing Test Performance in Children with ADHD

Directory of Open Access Journals (Sweden)

Ahmad Ghanizadeh

2013-01-01

Full Text Available  Introduction: The utility and discriminatory pattern of the clock face drawing test in ADHD is unclear. This study therefore compared Clock Face Drawing test performance in children with ADHD and controls.   Material & methods: 95 children with ADHD and 191 school children were matched for gender ratio and age. ADHD symptoms severities were assessed using DSM-IV ADHD checklist and their intellectual functioning was assessed. The participants completed three clock-drawing tasks, and the following four functions were assessed: Contour score, Numbers score, Hands setting score, and Center score    Results: All the subscales scores of the three clock drawing tests of the ADHD group were lower than that of the control group. In ADHD children, inattention and hyperactivity/impulsivity scores were not related with free drawn clock test scores. When pre-drawn contour test was performed, inattentiveness score was statistically associated with Number score. None of the other variables of age, gender, intellectual functioning, and hand use preference were associated with Numbers score. In pre-drawn clock, no association of ADHD symptoms with any CDT subscales was significant. In addition, more errors are observed with free drawn clock and Pre-drawn contour than pre-drawn clock.    Conclusion: Putting Numbers and Hands setting are more sensitive measures to screen ADHD than Contour and Center drawing. Test performance, except Hands setting, may have already reached a developmental plateau. It is probable that Hand setting deficit in children with ADHD may not decrease from age 8 to 14 years. Performance of children with ADHD is associated with the complexity of CDT.

VLBA imaging of the 3 mm SiO maser emission in the disk-wind from the massive protostellar system Orion Source I

Science.gov (United States)

Issaoun, S.; Goddi, C.; Matthews, L. D.; Greenhill, L. J.; Gray, M. D.; Humphreys, E. M. L.; Chandler, C. J.; Krumholz, M.; Falcke, H.

2017-10-01

Context. High-mass star formation remains poorly understood due to observational difficulties (e.g. high dust extinction and large distances) hindering the resolution of disk-accretion and outflow-launching regions. Aims: Orion Source I is the closest known massive young stellar object (YSO) and exceptionally powers vibrationally-excited SiO masers at radii within 100 AU, providing a unique probe of gas dynamics and energetics. We seek to observe and image these masers with Very Long Baseline Interferometry (VLBI). Methods: We present the first images of the 28SiO v = 1, J = 2-1 maser emission around Orion Source I observed at 86 GHz (λ3 mm) with the Very Long Baseline Array (VLBA). These images have high spatial ( 0.3 mas) and spectral ( 0.054 km s-1) resolutions. Results: We find that the λ3 mm masers lie in an X-shaped locus consisting of four arms, with blue-shifted emission in the south and east arms and red-shifted emission in the north and west arms. Comparisons with previous images of the 28SiO v = 1,2, J = 1-0 transitions at λ7 mm (observed in 2001-2002) show that the bulk of the J = 2-1 transition emission follows the streamlines of the J = 1-0 emission and exhibits an overall velocity gradient consistent with the gradient at λ7 mm. While there is spatial overlap between the λ3 mm and λ7 mm transitions, the λ3 mm emission, on average, lies at larger projected distances from Source I ( 44 AU compared with 35 AU for λ7 mm). The spatial overlap between the v = 1, J = 1-0 and J = 2-1 transitions is suggestive of a range of temperatures and densities where physical conditions are favorable for both transitions of a same vibrational state. However, the observed spatial offset between the bulk of emission at λ3 mm and λ7 mm possibly indicates different ranges of temperatures and densities for optimal excitation of the masers. We discuss different maser pumping models that may explain the observed offset. Conclusions: We interpret the λ3 mm and λ7 mm

A central role for ubiquitination within a circadian clock protein modification code

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Katarina eStojkovic

2014-08-01

Full Text Available Circadian rhythms, endogenous cycles of about 24 h in physiology, are generated by a master clock located in the suprachiasmatic nucleus of the hypothalamus and other clocks located in the brain and peripheral tissues. Circadian disruption is known to increase the incidence of various illnesses, such as mental disorders, metabolic syndrome and cancer. At the molecular level, periodicity is established by a set of clock genes via autoregulatory translation-transcription feedback loops. This clock mechanism is regulated by post-translational modifications such as phosphorylation and ubiquitination, which set the pace of the clock. Ubiquitination in particular has been found to regulate the stability of core clock components, but also other clock protein functions. Mutation of genes encoding ubiquitin ligases can cause either elongation or shortening of the endogenous circadian period. Recent research has also started to uncover roles for deubiquitination in the molecular clockwork. Here we review the role of the ubiquitin pathway in regulating the circadian clock and we propose that ubiquitination is a key element in a clock protein modification code that orchestrates clock mechanisms and circadian behavior over the daily cycle.

Redox rhythm reinforces the circadian clock to gate immune response.

Science.gov (United States)

Zhou, Mian; Wang, Wei; Karapetyan, Sargis; Mwimba, Musoki; Marqués, Jorge; Buchler, Nicolas E; Dong, Xinnian

2015-07-23

Recent studies have shown that in addition to the transcriptional circadian clock, many organisms, including Arabidopsis, have a circadian redox rhythm driven by the organism's metabolic activities. It has been hypothesized that the redox rhythm is linked to the circadian clock, but the mechanism and the biological significance of this link have only begun to be investigated. Here we report that the master immune regulator NPR1 (non-expressor of pathogenesis-related gene 1) of Arabidopsis is a sensor of the plant's redox state and regulates transcription of core circadian clock genes even in the absence of pathogen challenge. Surprisingly, acute perturbation in the redox status triggered by the immune signal salicylic acid does not compromise the circadian clock but rather leads to its reinforcement. Mathematical modelling and subsequent experiments show that NPR1 reinforces the circadian clock without changing the period by regulating both the morning and the evening clock genes. This balanced network architecture helps plants gate their immune responses towards the morning and minimize costs on growth at night. Our study demonstrates how a sensitive redox rhythm interacts with a robust circadian clock to ensure proper responsiveness to environmental stimuli without compromising fitness of the organism.

Molecular Mechanisms Regulating Temperature Compensation of the Circadian Clock

OpenAIRE

David M. Virshup; Rajesh Narasimamurthy

2017-01-01

An approximately 24-h biological timekeeping mechanism called the circadian clock is present in virtually all light-sensitive organisms from cyanobacteria to humans. The clock system regulates our sleep–wake cycle, feeding–fasting, hormonal secretion, body temperature, and many other physiological functions. Signals from the master circadian oscillator entrain peripheral clocks using a variety of neural and hormonal signals. Even centrally controlled internal temperature fluctuations can entr...

Hanle Detection for Optical Clocks

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Xiaogang Zhang

2015-01-01

Full Text Available Considering the strong inhomogeneous spatial polarization and intensity distribution of spontaneous decay fluorescence due to the Hanle effect, we propose and demonstrate a universe Hanle detection configuration of electron-shelving method for optical clocks. Experimental results from Ca atomic beam optical frequency standard with electron-shelving method show that a designed Hanle detection geometry with optimized magnetic field direction, detection laser beam propagation and polarization direction, and detector position can improve the fluorescence collection rate by more than one order of magnitude comparing with that of inefficient geometry. With the fixed 423 nm fluorescence, the improved 657 nm optical frequency standard signal intensity is presented. The potential application of the Hanle detection geometry designed for facilitating the fluorescence collection for optical lattice clock with a limited solid angle of the fluorescence collection has been discussed. The Hanle detection geometry is also effective for ion detection in ion optical clock and quantum information experiments. Besides, a cylinder fluorescence collection structure is designed to increase the solid angle of the fluorescence collection in Ca atomic beam optical frequency standard.

Minimal tool set for a prokaryotic circadian clock.

Science.gov (United States)

Schmelling, Nicolas M; Lehmann, Robert; Chaudhury, Paushali; Beck, Christian; Albers, Sonja-Verena; Axmann, Ilka M; Wiegard, Anika

2017-07-21

Circadian clocks are found in organisms of almost all domains including photosynthetic Cyanobacteria, whereby large diversity exists within the protein components involved. In the model cyanobacterium Synechococcus elongatus PCC 7942 circadian rhythms are driven by a unique KaiABC protein clock, which is embedded in a network of input and output factors. Homologous proteins to the KaiABC clock have been observed in Bacteria and Archaea, where evidence for circadian behavior in these domains is accumulating. However, interaction and function of non-cyanobacterial Kai-proteins as well as homologous input and output components remain mainly unclear. Using a universal BLAST analyses, we identified putative KaiC-based timing systems in organisms outside as well as variations within Cyanobacteria. A systematic analyses of publicly available microarray data elucidated interesting variations in circadian gene expression between different cyanobacterial strains, which might be correlated to the diversity of genome encoded clock components. Based on statistical analyses of co-occurrences of the clock components homologous to Synechococcus elongatus PCC 7942, we propose putative networks of reduced and fully functional clock systems. Further, we studied KaiC sequence conservation to determine functionally important regions of diverged KaiC homologs. Biochemical characterization of exemplary cyanobacterial KaiC proteins as well as homologs from two thermophilic Archaea demonstrated that kinase activity is always present. However, a KaiA-mediated phosphorylation is only detectable in KaiC1 orthologs. Our analysis of 11,264 genomes clearly demonstrates that components of the Synechococcus elongatus PCC 7942 circadian clock are present in Bacteria and Archaea. However, all components are less abundant in other organisms than Cyanobacteria and KaiA, Pex, LdpA, and CdpA are only present in the latter. Thus, only reduced KaiBC-based or even simpler, solely KaiC-based timing systems

Research Investigation Directed Toward Extending the Useful Range of the Electromagnetic Spectrum [Special Technical Report]: Further Aspects of the Theory of the Maser.

Science.gov (United States)

Shimoda, K.; Wang, T. C.; Townes, C. H.

1956-03-01

The theory of the molecular transitions which are induced by the microwave field in a maser and the effects of various design parameters are examined in detail. It is shown that the theoretical minimum detectable beam intensity when the maser is used as a spectrometer for the 3-3 line of ammonia is about 10{sup 9} molecules/sec under typical experimental conditions. Various systematic frequency shifts and random frequency fluctuations of the maser oscillator are discussed and evaluated. The most prominent of the former are the "frequency-pulling" effect which arises from detuning of the cavity and the Doppler shift due to the asymmetrical coupling of the beam with the two travelling wave components of the standing waves which are set up in the cavity. These two effects may produce fractional shifts as large as one part in 10{sup 9}. If adequate precautions are taken, however, they can be reduced to one part in 10{sup 10} or possibly less. The random fluctuations are shown to be of the order of one part in 10{sup 13} under typical operating conditions. For molecular beams in which the electric-dipole transition is used the TM{sub 010} mode is usually the most suitable for the maser which atomic beams in which magnetic transitions are utilized, the TE{sub 011} mode is to be preferred.

Time measurement - technical importance of most exact clocks

International Nuclear Information System (INIS)

Goebel, E.O.; Riehle, F.

2004-01-01

The exactness of the best atomic clocks currently shows a temporal variation of 1 second in 30 million years. This means that we have reached the point of the most exact frequency and time measurement ever. In the past, there was a trend towards increasing the exactness in an increasingly fast sequence. Will this trend continue? And who will profit from it? This article is meant to give answers to these questions. This is done by presenting first the level reached currently with the best atomic clocks and describing the research activities running worldwide with the aim of achieving even more exact clocks. In the second part, we present examples of various areas of technical subjects and research in which the most exact clocks are being applied presently and even more exact ones will be needed in the future [de

Fault-Tolerant Self-Stabilizing Distributed Clock Synchronization Protocol for Arbitrary Digraphs

Science.gov (United States)

Malekpour, Mahyar R. (Inventor)

2014-01-01

A self-stabilizing network in the form of an arbitrary, non-partitioned digraph includes K nodes having a synchronizer executing a protocol. K-1 monitors of each node may receive a Sync message transmitted from a directly connected node. When the Sync message is received, the logical clock value for the receiving node is set to between 0 and a communication latency value (gamma) if the clock value is less than a minimum event-response delay (D). A new Sync message is also transmitted to any directly connected nodes if the clock value is greater than or equal to both D and a graph threshold (T(sub S)). When the Sync message is not received the synchronizer increments the clock value if the clock value is less than a resynchronization period (P), and resets the clock value and transmits a new Sync message to all directly connected nodes when the clock value equals or exceeds P.

The Clock gene clone and its circadian rhythms in Pelteobagrus vachelli

Science.gov (United States)

Qin, Chuanjie; Shao, Ting

2015-05-01

The Clock gene, a key molecule in circadian systems, is widely distributed in the animal kingdom. We isolated a 936-bp partial cDNA sequence of the Clock gene ( Pva-clock) from the darkbarbel catfish Pelteobagrus vachelli that exhibited high identity with Clock genes of other species of fish and animals (65%-88%). The putative domains included a basic helix-loop-helix (bHLH) domain and two period-ARNT-single-minded (PAS) domains, which were also similar to those in other species of fish and animals. Pva-Clock was primarily expressed in the brain, and was detected in all of the peripheral tissues sampled. Additionally, the pattern of Pva-Clock expression over a 24-h period exhibited a circadian rhythm in the brain, liver and intestine, with the acrophase at zeitgeber time 21:35, 23:00, and 23:23, respectively. Our results provide insight into the function of the molecular Clock of P. vachelli.

A Method for Estimating BeiDou Inter-frequency Satellite Clock Bias

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LI Haojun

2016-02-01

Full Text Available A new method for estimating the BeiDou inter-frequency satellite clock bias is proposed, considering the shortage of the current methods. The constant and variable parts of the inter-frequency satellite clock bias are considered in the new method. The data from 10 observation stations are processed to validate the new method. The characterizations of the BeiDou inter-frequency satellite clock bias are also analyzed using the computed results. The results of the BeiDou inter-frequency satellite clock bias indicate that it is stable in the short term. The estimated BeiDou inter-frequency satellite clock bias results are molded. The model results show that the 10 parameters of model for each satellite can express the BeiDou inter-frequency satellite clock bias well and the accuracy reaches cm level. When the model parameters of the first day are used to compute the BeiDou inter-frequency satellite clock bias of the second day, the accuracy also reaches cm level. Based on the stability and modeling, a strategy for the BeiDou satellite clock service is presented to provide the reference of our BeiDou.

Intact interval timing in circadian CLOCK mutants.

Science.gov (United States)

Cordes, Sara; Gallistel, C R

2008-08-28

While progress has been made in determining the molecular basis for the circadian clock, the mechanism by which mammalian brains time intervals measured in seconds to minutes remains a mystery. An obvious question is whether the interval-timing mechanism shares molecular machinery with the circadian timing mechanism. In the current study, we trained circadian CLOCK +/- and -/- mutant male mice in a peak-interval procedure with 10 and 20-s criteria. The mutant mice were more active than their wild-type littermates, but there were no reliable deficits in the accuracy or precision of their timing as compared with wild-type littermates. This suggests that expression of the CLOCK protein is not necessary for normal interval timing.

A self-interfering clock as a "which path" witness.

Science.gov (United States)

Margalit, Yair; Zhou, Zhifan; Machluf, Shimon; Rohrlich, Daniel; Japha, Yonathan; Folman, Ron

2015-09-11

In Einstein's general theory of relativity, time depends locally on gravity; in standard quantum theory, time is global-all clocks "tick" uniformly. We demonstrate a new tool for investigating time in the overlap of these two theories: a self-interfering clock, comprising two atomic spin states. We prepare the clock in a spatial superposition of quantum wave packets, which evolve coherently along two paths into a stable interference pattern. If we make the clock wave packets "tick" at different rates, to simulate a gravitational time lag, the clock time along each path yields "which path" information, degrading the pattern's visibility. In contrast, in standard interferometry, time cannot yield "which path" information. This proof-of-principle experiment may have implications for the study of time and general relativity and their impact on fundamental effects such as decoherence and the emergence of a classical world. Copyright © 2015, American Association for the Advancement of Science.

Byzantine-fault tolerant self-stabilizing protocol for distributed clock synchronization systems

Science.gov (United States)

Malekpour, Mahyar R. (Inventor)

2010-01-01

A rapid Byzantine self-stabilizing clock synchronization protocol that self-stabilizes from any state, tolerates bursts of transient failures, and deterministically converges within a linear convergence time with respect to the self-stabilization period. Upon self-stabilization, all good clocks proceed synchronously. The Byzantine self-stabilizing clock synchronization protocol does not rely on any assumptions about the initial state of the clocks. Furthermore, there is neither a central clock nor an externally generated pulse system. The protocol converges deterministically, is scalable, and self-stabilizes in a short amount of time. The convergence time is linear with respect to the self-stabilization period.

The role of the mechanical clock in medieval science.

Science.gov (United States)

Álvarez, Víctor Pérez

2015-03-01

The invention and spread of the mechanical clock is a complex and multifaceted historical phenomenon. Some of these facets, such as its social impact, have been widely studied, but their scientific dimensions have often been dismissed. The mechanical clock was probably born as a scientific instrument for driving a model of the universe, and not only natural philosophers but also kings, nobles and other members of the social elites showed an interest in clocks as scientific instruments. Public clocks later spread a new way of telling time based on equal hours, laying the foundations for changes in time consciousness that would accelerate scientific thinking. Copyright © 2015 Elsevier Ltd. All rights reserved.

The endogenous circadian clock programs animals to eat at certain times of the 24-hour day: What if we ignore the clock?

Science.gov (United States)

Jiang, Peng; Turek, Fred W

2018-04-16

The discovery of the molecular mechanisms underlying the circadian clock, which functions in virtually every cell throughout the body to coordinate biological processes to anticipate and better adapt to daily rhythmic changes in the environment, is one of the major biomedical breakthroughs in the 20th century. Twenty years after this breakthrough, the biomedical community is now at a new frontier to incorporate the circadian clock mechanisms into many areas of biomedical research, as studies continue to reveal an important role of the circadian clock in a wide range of biological functions and diseases. A forefront of this exciting area is the research of interactions between the clock and energy metabolism. In this review, we summarize animal and human studies linking disruptions of the circadian clock, either environmental or genetic, to metabolic dysfunctions associated with obesity, diabetes, and other metabolic disorders. We also discuss how these advances in circadian biology may pave the way to revolutionize clinical practice in the era of precision medicine. Copyright © 2018 Elsevier Inc. All rights reserved.

Maintenance of time and frequency in the Jet Propulsion Laboratory's Deep Space Network using the Global Positioning System

Science.gov (United States)

Clements, P. A.; Borutzki, S. E.; Kirk, A.

1984-01-01

The Deep Space Network (DSN), managed by the Jet Propulsion Laboratory for NASA, must maintain time and frequency within specified limits in order to accurately track the spacecraft engaged in deep space exploration. Various methods are used to coordinate the clocks among the three tracking complexes. These methods include Loran-C, TV Line 10, Very Long Baseline Interferometry (VLBI), and the Global Positioning System (GPS). Calculations are made to obtain frequency offsets and Allan variances. These data are analyzed and used to monitor the performance of the hydrogen masers that provide the reference frequencies for the DSN Frequency and Timing System (DFT). Areas of discussion are: (1) a brief history of the GPS timing receivers in the DSN, (2) a description of the data and information flow, (3) data on the performance of the DSN master clocks and GPS measurement system, and (4) a description of hydrogen maser frequency steering using these data.

Linear theory of plasma Čerenkov masers

Science.gov (United States)

Birau, M.

1996-11-01

A different theoretical model of Čerenkov instability in the linear amplification regime of plasma Čerenkov masers is developed. The model assumes a cold relativistic annular electron beam propagating through a column of cold dense plasma, the two bodies being immersed in an infinite magnetic guiding field inside a perfect cylindrical waveguide. In order to simplify the calculations, a radial rectangular distribution of plasma and beam density is assumed and only azimuthal symmetric modes are under investigation. The model's difference consists of taking into account the whole plasma and beam electromagnetic structures in the interpretation of the Čerenkov instability. This model leads to alternative results such as the possibility of emission at several frequencies. In addition, the electric field is calculated taking into account its radial phase dependence, so that a map of the field in the interaction region can be presented.

The retinal clock in mammals: role in health and disease

Directory of Open Access Journals (Sweden)

Felder-Schmittbuhl MP

2017-05-01

Full Text Available Marie-Paule Felder-Schmittbuhl,1,* Hugo Calligaro,2 Ouria Dkhissi-Benyahya2,* 1Institute of Cellular and Integratives Neurosciences, UPR3212, CNRS, Université de Strasbourg, Strasbourg, 2University of Lyon, Stem Cell and Brain Research Institute, INSERM U1208, Bron, France *These authors contributed equally to this work Abstract: The mammalian retina contains an extraordinary diversity of cell types that are highly organized into precise circuits to perceive and process visual information in a dynamic manner and transmit it to the brain. Above this builds up another level of complex dynamic, orchestrated by a circadian clock located within the retina, which allows retinal physiology, and hence visual function, to adapt to daily changes in light intensity. The mammalian retina is a remarkable model of circadian clock because it harbors photoreception, self-sustained oscillator function, and physiological outputs within the same tissue. However, the location of the retinal clock in mammals has been a matter of long debate. Current data have shown that clock properties are widely distributed among retinal cells and that the retina is composed of a network of circadian clocks located within distinct cellular layers. Nevertheless, the identity of the major pacemaker, if any, still warrants identification. In addition, the retina coordinates rhythmic behavior by providing visual input to the master hypothalamic circadian clock in the suprachiasmatic nuclei (SCN. This light entrainment of the SCN to the light/dark cycle involves a network of retinal photoreceptor cells: rods, cones, and intrinsically photosensitive retinal ganglion cells (ipRGCs. Although it was considered that these photoreceptors synchronized both retinal and SCN clocks, new data challenge this view, suggesting that none of these photoreceptors is involved in photic entrainment of the retinal clock. Because circadian organization is a ubiquitous feature of the retina and controls

Expression conservation within the circadian clock of a monocot: natural variation at barley Ppd-H1 affects circadian expression of flowering time genes, but not clock orthologs.

Science.gov (United States)

Campoli, Chiara; Shtaya, Munqez; Davis, Seth J; von Korff, Maria

2012-06-21

The circadian clock is an endogenous mechanism that coordinates biological processes with daily changes in the environment. In plants, circadian rhythms contribute to both agricultural productivity and evolutionary fitness. In barley, the photoperiod response regulator and flowering-time gene Ppd-H1 is orthologous to the Arabidopsis core-clock gene PRR7. However, relatively little is known about the role of Ppd-H1 and other components of the circadian clock in temperate crop species. In this study, we identified barley clock orthologs and tested the effects of natural genetic variation at Ppd-H1 on diurnal and circadian expression of clock and output genes from the photoperiod-response pathway. Barley clock orthologs HvCCA1, HvGI, HvPRR1, HvPRR37 (Ppd-H1), HvPRR73, HvPRR59 and HvPRR95 showed a high level of sequence similarity and conservation of diurnal and circadian expression patterns, when compared to Arabidopsis. The natural mutation at Ppd-H1 did not affect diurnal or circadian cycling of barley clock genes. However, the Ppd-H1 mutant was found to be arrhythmic under free-running conditions for the photoperiod-response genes HvCO1, HvCO2, and the MADS-box transcription factor and vernalization responsive gene Vrn-H1. We suggest that the described eudicot clock is largely conserved in the monocot barley. However, genetic differentiation within gene families and differences in the function of Ppd-H1 suggest evolutionary modification in the angiosperm clock. Our data indicates that natural variation at Ppd-H1 does not affect the expression level of clock genes, but controls photoperiodic output genes. Circadian control of Vrn-H1 in barley suggests that this vernalization responsive gene is also controlled by the photoperiod-response pathway. Structural and functional characterization of the barley circadian clock will set the basis for future studies of the adaptive significance of the circadian clock in Triticeae species.

The Chip-Scale Atomic Clock - Recent Development Progress

Science.gov (United States)

2004-09-01

35th Annual Precise Time and Time Interval (PTTI) Meeting 467 THE CHIP-SCALE ATOMIC CLOCK – RECENT DEVELOPMENT PROGRESS R. Lutwak ...1] R. Lutwak , et al., 2003, “The Chip-Scale Atomic Clock – Coherent Population Trapping vs. Conventional Interrogation,” in

SiO maser emission as a density tracer of circumstellar envelopes

Science.gov (United States)

Stroh, Michael; Pihlstrom, Ylva; Sjouwerman, Lorant

2018-06-01

The circumstellar envelopes (CSEs) of evolved stars offer a method to construct a sample of point-masses along the full Galactic plane, which can be used to test models of the gravitational potential. In the CSEs of red giants, SiO maser emission is frequently observed at 43 and 86 GHz, providing line-of-sight velocities. The Bulge Asymmetries and Dynamical Evolution (BAaDE) project aims to explore the complex structure of the inner Galaxy and Galactic Bulge, by observing 43 GHz SiO at the Very Large Array and 86 GHz SiO at the Atacama Large Millimeter/submillimeter Array, with an expected final sample of about 20,000 line-of-sight velocities and positions. We observed the 43 GHz and 86 GHz transitions near-simultaneously in a subsample of the sources using the Australia Telescope Compact Array and found that on average the 43 GHz v=1 line is 1.3 times stronger than the 86 GHz v=1 line. The presence of a detectable 43 GHz v=3 line alters the statistics, consistent with the SiO masers displaying 43 GHz v=3 emission arising in a denser regime in the circumstellar shell compared to those without. Comparing our results with radiative models implies that the 43 GHz v=3 line is a tracer of density variations caused by stellar pulsations. We will discuss these results in the context of the BAaDE project.

Clock synchronization and dispersion

International Nuclear Information System (INIS)

Giovannetti, Vittorio; Lloyd, Seth; Maccone, Lorenzo; Wong, Franco N C

2002-01-01

We present a method to defeat effects of dispersion of timing signals when synchronizing clocks. It is based on the recently proposed 'conveyor belt synchronization' scheme and on the quantum dispersion cancellation effect

MM-wave cyclotron auto-resonance maser for plasma heating

Science.gov (United States)

Ceccuzzi, S.; Dattoli, G.; Di Palma, E.; Doria, A.; Gallerano, G. P.; Giovenale, E.; Mirizzi, F.; Spassovsky, I.; Ravera, G. L.; Surrenti, V.; Tuccillo, A. A.

2014-02-01

Heating and Current Drive systems are of outstanding relevance in fusion plasmas, magnetically confined in tokamak devices, as they provide the tools to reach, sustain and control burning conditions. Heating systems based on the electron cyclotron resonance (ECRH) have been extensively exploited on past and present machines DEMO, and the future reactor will require high frequencies. Therefore, high power (≥1MW) RF sources with output frequency in the 200 - 300 GHz range would be necessary. A promising source is the so called Cyclotron Auto-Resonance Maser (CARM). Preliminary results of the conceptual design of a CARM device for plasma heating, carried out at ENEA-Frascati will be presented together with the planned R&D development.

Association between circadian clock genes and diapause incidence in Drosophila triauraria.

Directory of Open Access Journals (Sweden)

Hirokazu Yamada

Full Text Available Diapause is an adaptive response triggered by seasonal photoperiodicity to overcome unfavorable seasons. The photoperiodic clock is a system that controls seasonal physiological processes, but our knowledge about its physiological mechanisms and genetic architecture remains incomplete. The circadian clock is another system that controls daily rhythmic physiological phenomena. It has been argued that there is a connection between the two clocks. To examine the genetic connection between them, we analyzed the associations of five circadian clock genes (period, timeless, Clock, cycle and cryptochrome with the occurrence of diapause in Drosophila triauraria, which shows a robust reproductive diapause with clear photoperiodicity. Non-diapause strains found in low latitudes were compared in genetic crosses with the diapause strain, in which the diapause trait is clearly dominant. Single nucleotide polymorphism and deletion analyses of the five circadian clock genes in backcross progeny revealed that allelic differences in timeless and cryptochrome between the strains were additively associated with the differences in the incidence of diapause. This suggests that there is a molecular link between certain circadian clock genes and the occurrence of diapause.

Transverse particle acceleration techniques using lasers and masers

International Nuclear Information System (INIS)

Schoen, N.C.

1983-01-01

The concept discussed herein uses an intense traveling electromagnetic wave, produced by a laser or maser source, to accelerate electrons in the Rayleigh region of a focused beam. Although the possibility of non-synchronous acceleration has been considered, very little analysis of potential device configurations has been reported. Computer simulations of the acceleration process indicate practical figure of merit values in the range of 100 MeV/m for achievable electric field strengths with current technology. The development of compact, high energy electron accelerators will provide an essential component for many new technologies. Such as high power free electron lasers, X-ray and VUV sources, and high power millimeter and microwave devices. Considerable effort has been directed toward studies of new concepts for electron acceleration, including inverse free electron lasers, GYRACS, and modified betatrons

MTL-Model Checking of One-Clock Parametric Timed Automata is Undecidable

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Karin Quaas

2014-03-01

Full Text Available Parametric timed automata extend timed automata (Alur and Dill, 1991 in that they allow the specification of parametric bounds on the clock values. Since their introduction in 1993 by Alur, Henzinger, and Vardi, it is known that the emptiness problem for parametric timed automata with one clock is decidable, whereas it is undecidable if the automaton uses three or more parametric clocks. The problem is open for parametric timed automata with two parametric clocks. Metric temporal logic, MTL for short, is a widely used specification language for real-time systems. MTL-model checking of timed automata is decidable, no matter how many clocks are used in the timed automaton. In this paper, we prove that MTL-model checking for parametric timed automata is undecidable, even if the automaton uses only one clock and one parameter and is deterministic.

Application of radioisotope for radio-luminous watch and clock industry in Japan

International Nuclear Information System (INIS)

Murayama, Yoshihiko

1981-01-01

In 1979, Japan became No. 1 watch and clock production country in the world, and has produced 88 million watches and 59 million clocks in 1980. About 65% of them were exported. The production of radio-luminous watches and clocks in 1980 was estimated as 13 million and 11 million, respectively, and has increased by 40% as compared with the previous year. In Japan, the law concerning the prevention of radiation injuries due to radioisotopes and others is applied to radio-luminous watches and clocks, because radioactive substances are contained in luminous paint, and the production is regulated by the law as unsealed RI-using establishments. The permitted establishments engaging in radio-luminous watches and clocks are 3 luminous paint makers, 9 painting works and 35 watch and clock assembling plants. The RI utilized for radio-luminous watches and clocks is limited to Pm-147 at present, and 3788 Ci was used in 1980. About 70 years have elapsed since luminous paint was used for watches and clocks for the first time. The ISO instituted the international standard on radio-luminous paint for watches and clocks in 1975. The beta-ray emitted by Pm-147 is shielded perfectly by glasses and cases, and only the dose of brems-strahlung X-ray is the problem. The radiation control in radio-luminous watch and clock plants is described. (Kako, I.)

Design of a tunable 4-MW Free Electron Maser for heating fusion plasmas

International Nuclear Information System (INIS)

Caplan, M.; Kamin, G.; Shang, C.C.; Lindquist, W.

1993-09-01

There is an ongoing program at the FOM institute, The Netherlands, to develop a 1-MW, long-pulse, 200-Ghz Free Electron Maser (FEM) using a DC accelerator system with depressed collector. We present an extrapolation of this design to more than 4MW of output microwave power in order to reduce the cost per kW and increase the power per module in a plasma heating system

Design of a tunable 4-MW free electron maser for heating fusion plasmas

International Nuclear Information System (INIS)

Caplan, M.; Kamin, G.; Shang, C.C.; Lindquist, W.

1993-01-01

There is an ongoing program at the FOM institute, The Netherlands, to develop a 1 -MW, long-pulse, 200-GHz Free Electron Maser (FEM) using a DC accelerator system with depressed collector. The authors present an extrapolation of this design to more than 4 MW of output microwave power in order to reduce the cost per kW and increase the power per module in a plasma heating system

Protecting Clock Synchronization: Adversary Detection through Network Monitoring

Directory of Open Access Journals (Sweden)

Elena Lisova

2016-01-01

Full Text Available Nowadays, industrial networks are often used for safety-critical applications with real-time requirements. Such applications usually have a time-triggered nature with message scheduling as a core property. Scheduling requires nodes to share the same notion of time, that is, to be synchronized. Therefore, clock synchronization is a fundamental asset in real-time networks. However, since typical standards for clock synchronization, for example, IEEE 1588, do not provide the required level of security, it raises the question of clock synchronization protection. In this paper, we identify a way to break synchronization based on the IEEE 1588 standard, by conducting a man-in-the-middle (MIM attack followed by a delay attack. A MIM attack can be accomplished through, for example, Address Resolution Protocol (ARP poisoning. Using the AVISPA tool, we evaluate the potential to perform a delay attack using ARP poisoning and analyze its consequences showing both that the attack can, indeed, break clock synchronization and that some design choices, such as a relaxed synchronization condition mode, delay bounding, and using knowledge of environmental conditions, can make the network more robust/resilient against these kinds of attacks. Lastly, a Configuration Agent is proposed to monitor and detect anomalies introduced by an adversary performing attacks targeting clock synchronization.

Mining for novel candidate clock genes in the circadian regulatory network

OpenAIRE

Bhargava, Anuprabha; Herzel, Hanspeter; Ananthasubramaniam, Bharath

2015-01-01

Background Most physiological processes in mammals are temporally regulated by means of a master circadian clock in the brain and peripheral oscillators in most other tissues. A transcriptional-translation feedback network of clock genes produces near 24 h oscillations in clock gene and protein expression. Here, we aim to identify novel additions to the clock network using a meta-analysis of public chromatin immunoprecipitation sequencing (ChIP-seq), proteomics and protein-protein interaction...

Clock Technology Development in the Laser Cooling and Atomic Physics (LCAP) Program

Science.gov (United States)

Seidel, Dave; Thompson, R. J.; Klipstein, W. M.; Kohel, J.; Maleki, L.

2000-01-01

This paper presents the Laser Cooling and Atomic Physics (LCAP) program. It focuses on clock technology development. The topics include: 1) Overview of LCAP Flight Projects; 2) Space Clock 101; 3) Physics with Clocks in microgravity; 4) Space Clock Challenges; 5) LCAP Timeline; 6) International Space Station (ISS) Science Platforms; 7) ISS Express Rack; 8) Space Qualification of Components; 9) Laser Configuration; 10) Clock Rate Comparisons: GPS Carrier Phase Frequency Transfer; and 11) ISS Model Views. This paper is presented in viewgraph form.

Clocking Scheme for Switched-Capacitor Circuits

DEFF Research Database (Denmark)

Steensgaard-Madsen, Jesper

1998-01-01

A novel clocking scheme for switched-capacitor (SC) circuits is presented. It can enhance the understanding of SC circuits and the errors caused by MOSFET (MOS) switches. Charge errors, and techniques to make SC circuits less sensitive to them are discussed.......A novel clocking scheme for switched-capacitor (SC) circuits is presented. It can enhance the understanding of SC circuits and the errors caused by MOSFET (MOS) switches. Charge errors, and techniques to make SC circuits less sensitive to them are discussed....

A (201)Hg+ Comagnetometer for (199)Hg+ Trapped Ion Space Atomic Clocks

Science.gov (United States)

Burt, Eric A.; Taghavi, Shervin; Tjoelker, Robert L.

2011-01-01

A method has been developed for unambiguously measuring the exact magnetic field experienced by trapped mercury ions contained within an atomic clock intended for space applications. In general, atomic clocks are insensitive to external perturbations that would change the frequency at which the clocks operate. On a space platform, these perturbative effects can be much larger than they would be on the ground, especially in dealing with the magnetic field environment. The solution is to use a different isotope of mercury held within the same trap as the clock isotope. The magnetic field can be very accurately measured with a magnetic-field-sensitive atomic transition in the added isotope. Further, this measurement can be made simultaneously with normal clock operation, thereby not degrading clock performance. Instead of using a conventional magnetometer to measure ambient fields, which would necessarily be placed some distance away from the clock atoms, first order field-sensitive atomic transition frequency changes in the atoms themselves determine the variations in the magnetic field. As a result, all ambiguity over the exact field value experienced by the atoms is removed. Atoms used in atomic clocks always have an atomic transition (often referred to as the clock transition) that is sensitive to magnetic fields only in second order, and usually have one or more transitions that are first-order field sensitive. For operating parameters used in the (199)Hg(+) clock, the latter can be five orders of magnitude or more sensitive to field fluctuations than the clock transition, thereby providing an unambiguous probe of the magnetic field strength.

British domestic synchronous clocks 1930-1980 the rise and fall of a technology

CERN Document Server

Pook, Leslie Philip

2015-01-01

This book complements available one-make books on domestic synchronous clocks. It is also a history of science book that sets British domestic synchronous clocks, their manufacturers and technology in their social context. Part I covers the historical background, British domestic synchronous clock manufacturers and brands, how synchronous clocks work, domestic synchronous clock cases, practical advice on the servicing of domestic synchronous clocks, and analysis of the marketing and reliability of British domestic synchronous clocks. This analysis provides an explanation of the rise and eventual fall of their technology. Part II contains galleries of a selection of British domestic synchronous clocks, and of the movements with which they are fitted. There is a front and back view of each clock, together with a brief description. Views of each movement include views with the movement partly dismantled, together with a brief technical description of the movement. This profusely illustrated book is primarily fo...

Dual-Mode Operation of an Optical Lattice Clock Using Strontium and Ytterbium Atoms.

Science.gov (United States)

Akamatsu, Daisuke; Kobayashi, Takumi; Hisai, Yusuke; Tanabe, Takehiko; Hosaka, Kazumoto; Yasuda, Masami; Hong, Feng-Lei

2018-06-01

We have developed an optical lattice clock that can operate in dual modes: a strontium (Sr) clock mode and an ytterbium (Yb) clock mode. Dual-mode operation of the Sr-Yb optical lattice clock is achieved by alternately cooling and trapping 87 Sr and 171 Yb atoms inside the vacuum chamber of the clock. Optical lattices for Sr and Yb atoms were arranged with horizontal and vertical configurations, respectively, resulting in a small distance of the order of between the trapped Sr and Yb atoms. The 1 S 0 - 3 P 0 clock transitions in the trapped atoms were interrogated in turn and the clock lasers were stabilized to the transitions. We demonstrated the frequency ratio measurement of the Sr and Yb clock transitions by using the dual-mode operation of the Sr-Yb optical lattice clock. The dual-mode operation can reduce the uncertainty of the blackbody radiation shift in the frequency ratio measurement, because both Sr and Yb atoms share the same blackbody radiation.

A bunch clock for the Advanced Photon Source

International Nuclear Information System (INIS)

Lenkszus, F.R.; Laird, R.J.

1997-01-01

A bunch clock timing module has been developed for use by Advanced Photon Source beamlines. The module provides bunch pattern and timing information that can be used to trigger beamline data collection equipment. The module is fully integrated into the control system software (EPICS) which automatically loads it with the storage ring fill pattern at injection time. Fast timing outputs (1 ns FWHM) for each stored bunch are generated using the storage ring low-level rf and revolution clock as input references. Fiber-optic-based transmitters and receivers are used to transmit a 352-MHz low-level rf reference to distributed bunch clock modules. The bunch clock module is a single-width VME module and may be installed in a VME crate located near beamline instrumentation. A prototype has been in use on the SRI CAT beamline for over a year. The design and integration into the control system timing software along with measured performance results are presented

Relativistic theory for syntonization of clocks in the vicinity of the Earth

Science.gov (United States)

Wolf, Peter; Petit, G.

1995-01-01

A well known prediction of Einstein's general theory of relativity states that two ideal clocks that move with a relative velocity, and are submitted to different gravitational fields will, in general, be observed to run at different rates. Similarly the rate of a clock with respect to the coordinate time of some spacetime reference system is dependent on the velocity of the clock in that reference system and on the gravitational fields it is submitted to. For the syntonization of clocks and the realization of coordinate times (like TAI) this rate shift has to be taken into account at an accuracy level which should be below the frequency stability of the clocks in question, i.e. all terms that are larger than the instability of the clocks should be corrected for. We present a theory for the calculation of the relativistic rate shift for clocks in the vicinity of the Earth, including all terms larger than one part in 10(exp 18). This, together with previous work on clock synchronization (Petit & Wolf 1993, 1994), amounts to a complete relativistic theory for the realization of coordinate time scales at picosecond synchronization and 10(exp -18) syntonization accuracy, which should be sufficient to accommodate future developments in time transfer and clock technology.

A new stochastic model considering satellite clock interpolation errors in precise point positioning

Science.gov (United States)

Wang, Shengli; Yang, Fanlin; Gao, Wang; Yan, Lizi; Ge, Yulong

2018-03-01

Precise clock products are typically interpolated based on the sampling interval of the observational data when they are used for in precise point positioning. However, due to the occurrence of white noise in atomic clocks, a residual component of such noise will inevitable reside within the observations when clock errors are interpolated, and such noise will affect the resolution of the positioning results. In this paper, which is based on a twenty-one-week analysis of the atomic clock noise characteristics of numerous satellites, a new stochastic observation model that considers satellite clock interpolation errors is proposed. First, the systematic error of each satellite in the IGR clock product was extracted using a wavelet de-noising method to obtain the empirical characteristics of atomic clock noise within each clock product. Then, based on those empirical characteristics, a stochastic observation model was structured that considered the satellite clock interpolation errors. Subsequently, the IGR and IGS clock products at different time intervals were used for experimental validation. A verification using 179 stations worldwide from the IGS showed that, compared with the conventional model, the convergence times using the stochastic model proposed in this study were respectively shortened by 4.8% and 4.0% when the IGR and IGS 300-s-interval clock products were used and by 19.1% and 19.4% when the 900-s-interval clock products were used. Furthermore, the disturbances during the initial phase of the calculation were also effectively improved.

Master Clock and Time-Signal-Distribution System

Science.gov (United States)

Tjoelker, Robert; Calhoun, Malcolm; Kuhnle, Paul; Sydnor, Richard; Lauf, John

2007-01-01

A timing system comprising an electronic master clock and a subsystem for distributing time signals from the master clock to end users is undergoing development to satisfy anticipated timing requirements of NASA s Deep Space Network (DSN) for the next 20 to 30 years. This system has a modular, flexible, expandable architecture that is easier to operate and maintain than the present frequency and timing subsystem (FTS).

Estudio de Maseres Circunestelares de Monoxido de Silicio con muy alta Resolucion Espacial

Science.gov (United States)

Soria-Ruiz, Rebeca

2006-03-01

We present high-spatial and high-spectral resolution studies of SiO masers in the circumstellar envelopes of late-type stars. These masers occur in the inner layers of the CSEs, in a region dominated by the stellar pulsation, thus being good (if not the only) probes available to understand the physics in these regions. Using the NRAO Very Long Baseline Array, we have produced maps of the 28SiO v=1 and v=2 J=1-0 and J=2-1 transitions towards several AGB stars: two Mira-type (TXCam and RLeo), one OH/IR (IRC+10011) and one S-type (xCyg) stars. The 29SiO v=0 J=1-0 and J=2-1 emission has also been studied. The spatial distributions retrieved, some of them for the first time, are in clear contradiction with the predictions of the models developed to date. We suggest that spectral line overlap may explain the results obtained. This work has been conducted by Dr. Javier Alcolea Jimenez and Dr. Francisco Colomer Sanmartin, at Observatorio Astronomico Nacional (Spain). The PhD thesis manuscript, in spanish, is available at ftp://ftp.oan.es/pub/users/r.soria/TESIS-RSoria.pdf .

Clock synchronization by remote detection of correlated photon pairs

Energy Technology Data Exchange (ETDEWEB)

Ho, Caleb; Lamas-Linares, AntIa; Kurtsiefer, Christian [Centre for Quantum Technologies, National University of Singapore, 3 Science Drive 2, 117543 (Singapore)], E-mail: christian.kurtsiefer@gmail.com

2009-04-15

In this study, we present an algorithm to detect the time and frequency differences of independent clocks based on observation of time-correlated photon pairs. This enables remote coincidence identification in entanglement-based quantum key distribution schemes without dedicated coincidence hardware, pulsed sources with a timing structure or very stable reference clocks. We discuss the method for typical operating conditions and show that the requirement for reference clock accuracy can be relaxed by about five orders of magnitude in comparison with previous schemes.

System-wide power management control via clock distribution network

Science.gov (United States)

Coteus, Paul W.; Gara, Alan; Gooding, Thomas M.; Haring, Rudolf A.; Kopcsay, Gerard V.; Liebsch, Thomas A.; Reed, Don D.

2015-05-19

An apparatus, method and computer program product for automatically controlling power dissipation of a parallel computing system that includes a plurality of processors. A computing device issues a command to the parallel computing system. A clock pulse-width modulator encodes the command in a system clock signal to be distributed to the plurality of processors. The plurality of processors in the parallel computing system receive the system clock signal including the encoded command, and adjusts power dissipation according to the encoded command.

Complementary approaches to understanding the plant circadian clock

Directory of Open Access Journals (Sweden)

Ozgur E. Akman

2010-02-01

Full Text Available Circadian clocks are oscillatory genetic networks that help organisms adapt to the 24-hour day/night cycle. The clock of the green alga Ostreococcus tauri is the simplest plant clock discovered so far. Its many advantages as an experimental system facilitate the testing of computational predictions. We present a model of the Ostreococcus clock in the stochastic process algebra Bio-PEPA and exploit its mapping to different analysis techniques, such as ordinary differential equations, stochastic simulation algorithms and model-checking. The small number of molecules reported for this system tests the limits of the continuous approximation underlying differential equations. We investigate the difference between continuous-deterministic and discrete-stochastic approaches. Stochastic simulation and model-checking allow us to formulate new hypotheses on the system behaviour, such as the presence of self-sustained oscillations in single cells under constant light conditions. We investigate how to model the timing of dawn and dusk in the context of model-checking, which we use to compute how the probability distributions of key biochemical species change over time. These show that the relative variation in expression level is smallest at the time of peak expression, making peak time an optimal experimental phase marker. Building on these analyses, we use approaches from evolutionary systems biology to investigate how changes in the rate of mRNA degradation impacts the phase of a key protein likely to affect fitness. We explore how robust this circadian clock is towards such potential mutational changes in its underlying biochemistry. Our work shows that multiple approaches lead to a more complete understanding of the clock.

A simple electromagnetic model for the light clock of special relativity

International Nuclear Information System (INIS)

Smith, Glenn S

2011-01-01

Thought experiments involving a light clock are common in introductory treatments of special relativity, because they provide a simple way of demonstrating the non-intuitive phenomenon of time dilation. The properties of the ray or pulse of light that is continuously reflected between the parallel mirrors of the clock are often stated vaguely and sometimes involve implicitly other relativistic effects, such as aberration. While this approach is adequate for an introduction, it should be supplemented by a more accurate analysis of the light clock once the formulae for the Lorentz transformation and the transformation of the electromagnetic field have been developed. A simple yet accurate electromagnetic model for the light clock is presented for this purpose. In this model, the ray of light in the qualitative treatment is replaced by a guided wave in a parallel-plate waveguide. Expressions for the electromagnetic field and energy density within the waveguide are determined in the inertial frame in which the clock is at rest and the laboratory frame in which the clock is moving with constant velocity. The analytical expressions and graphical results obtained clearly demonstrate the operation of the clock and time dilation, as well as other interesting relativistic effects.

Small-signal analysis and particle-in-cell simulations of planar dielectric Cherenkov masers for use as high-frequency, moderate-power broadband amplifiers

International Nuclear Information System (INIS)

Carlsten, Bruce E.

2002-01-01

A small-signal gain analysis of the planar dielectric Cherenkov maser is presented. The analysis results in a Pierce gain solution, with three traveling-wave modes. The analysis shows that the dielectric Cherenkov maser has a remarkable broadband tuning ability near cutoff, while maintaining reasonable gain rates. Numerical simulations verifying the small-signal gain results are presented, using a particle-in-cell code adapted specifically for planar traveling-wave tubes. An instantaneous bandwidth is numerically shown to be very large, and saturated efficiency for a nominal high-power design is shown to be in the range of standard untapered traveling-wave tubes

ClockWork: a Real-Time Feasibility Analysis Tool

NARCIS (Netherlands)

Jansen, P.G.; Hanssen, F.T.Y.; Mullender, Sape J.

ClockWork shows that we can improve the flexibility and efficiency of real-time kernels. We do this by proposing methods for scheduling based on so-called Real-Time Transactions. ClockWork uses Real-Time Transactions which allow scheduling decisions to be taken by the system. A programmer does not

Design and Construction of an Atomic Clock on an Atom Chip

International Nuclear Information System (INIS)

Reinhard, Friedemann

2009-01-01

We describe the design and construction of an atomic clock on an atom chip, intended as a secondary standard, with a stability in the range of few 10 -13 at 1 s. This clock is based on a two-photon transition between the hyperfine states |F = 1; m F = -1> and |2; 1> of the electronic ground state of the 87 Rb atom. This transition is interrogated using a Ramsey scheme, operating on either a cloud of thermal atoms or a Bose-Einstein condensate. In contrast to atomic fountain clocks, this clock is magnetically trapped on an atom chip. We describe a theoretical model of the clock stability and the design and construction of a dedicated apparatus. It is able to control the magnetic field at the relative 10 -5 level and features a hybrid atom chip, containing DC conductors as well as a microwave transmission line for the clock interrogation. (author)

One-liter Hg ion clock for space and ground applications

Science.gov (United States)

Prestage, John D.; Chung, Sang; Le, Thanh; Beach, Maggie; Maleki, Lute; Tjoelker, Robert L.

2003-01-01

We describe the development of a small Hg ion clock suitable for space use. A small clock occupying 1-2 liters volume and producing stability of 10 to the power negative twelve, divided by square root pi would significantly advance the state of space-qualified atomic clocks. Based on recent measurements, this technology should produce long-term stability as good as 10 to the power negative fifteen.

Telling time from analog and digital clocks: A multiple-route account

NARCIS (Netherlands)

Korvorst, M.H.W.; Roelofs, A.P.A.; Levelt, W.J.M.

2007-01-01

Does the naming of clocks always require conceptual preparation? To examine this question, speakers were presented with analog and digital clocks that had to be named in Dutch using either a relative (e.g., "quarter to four") or an absolute (e.g., "three forty-five") clock time expression format.

Diurnal oscillations of soybean circadian clock and drought responsive genes.

Directory of Open Access Journals (Sweden)

Juliana Marcolino-Gomes

Full Text Available Rhythms produced by the endogenous circadian clock play a critical role in allowing plants to respond and adapt to the environment. While there is a well-established regulatory link between the circadian clock and responses to abiotic stress in model plants, little is known of the circadian system in crop species like soybean. This study examines how drought impacts diurnal oscillation of both drought responsive and circadian clock genes in soybean. Drought stress induced marked changes in gene expression of several circadian clock-like components, such as LCL1-, GmELF4- and PRR-like genes, which had reduced expression in stressed plants. The same conditions produced a phase advance of expression for the GmTOC1-like, GmLUX-like and GmPRR7-like genes. Similarly, the rhythmic expression pattern of the soybean drought-responsive genes DREB-, bZIP-, GOLS-, RAB18- and Remorin-like changed significantly after plant exposure to drought. In silico analysis of promoter regions of these genes revealed the presence of cis-elements associated both with stress and circadian clock regulation. Furthermore, some soybean genes with upstream ABRE elements were responsive to abscisic acid treatment. Our results indicate that some connection between the drought response and the circadian clock may exist in soybean since (i drought stress affects gene expression of circadian clock components and (ii several stress responsive genes display diurnal oscillation in soybeans.

Inversion mechanisms for OH main lines astrophysical masers

International Nuclear Information System (INIS)

Elitzur, M.

1977-01-01

Excitation processes that can lead to inversion of the main lines of the OH ground state are discussed. Due to the frequency dependence of the emission coefficient of dust, far-IR emitted by warm enough dust can excite the upper halves of the Λ-doublets of rotational levels more strongly than the lower halves. The cascade back to the ground state will then invert the main lines and it is shown that this mechanism can explain rather well the main lines emission from OH-IR stars. The main lines masers associated with compact HII regions are discussed extensively. It is argued that the most plausible explanation for them is a model based on the mechanism suggested some time ago by Johnston where the inversion is due to collisional excitation by streams of uni-directional electrons. (author)

Optical lattice clock with strontium atoms: a second generation of cold atom clocks

International Nuclear Information System (INIS)

Le Targat, R.

2007-07-01

Atomic fountains, based on a microwave transition of Cesium or Rubidium, constitute the state of the art atomic clocks, with a relative accuracy close to 10 -16 . It nevertheless appears today that it will be difficult to go significantly beyond this level with this kind of device. The use of an optical transition, the other parameters being unchanged, gives hope for a 4 or 5 orders of magnitude improvement of the stability and of the relative uncertainty on most systematic effects. As for motional effects on the atoms, they can be controlled on a very different manner if they are trapped in an optical lattice instead of experiencing a free ballistic flight stage, characteristic of fountains. The key point of this approach lies in the fact that the trap can be operated in such a way that a well chosen, weakly allowed, J=0 → J=0 clock transition can be free from light shift effects. In this respect, the strontium atom is one of the most promising candidate, the 1S 0 → 3P 0 transition has a natural width of 1 mHz, and several other easily accessible transitions can be used to efficiently laser cool atoms down to 10 μK. This thesis demonstrates the experimental feasibility of an optical lattice clock based on the strontium atom, and reports on a preliminary evaluation of the relative accuracy with the fermionic isotope 87 Sr, at a level of a few 10 -15 . (author)

Standard Clock in primordial density perturbations and cosmic microwave background

International Nuclear Information System (INIS)

Chen, Xingang; Namjoo, Mohammad Hossein

2014-01-01

Standard Clocks in the primordial epoch leave a special type of features in the primordial perturbations, which can be used to directly measure the scale factor of the primordial universe as a function of time a(t), thus discriminating between inflation and alternatives. We have started to search for such signals in the Planck 2013 data using the key predictions of the Standard Clock. In this Letter, we summarize the key predictions of the Standard Clock and present an interesting candidate example in Planck 2013 data. Motivated by this candidate, we construct and compute full Standard Clock models and use the more complete prediction to make more extensive comparison with data. Although this candidate is not yet statistically significant, we use it to illustrate how Standard Clocks appear in Cosmic Microwave Background (CMB) and how they can be further tested by future data. We also use it to motivate more detailed theoretical model building

The Clock mutant mouse is a novel experimental model for nocturia and nocturnal polyuria.

Science.gov (United States)

Ihara, Tatsuya; Mitsui, Takahiko; Nakamura, Yuki; Kira, Satoru; Miyamoto, Tatsuya; Nakagomi, Hiroshi; Sawada, Norifumi; Hirayama, Yuri; Shibata, Keisuke; Shigetomi, Eiji; Shinozaki, Yoichi; Yoshiyama, Mitsuharu; Andersson, Karl-Erik; Nakao, Atsuhito; Takeda, Masayuki; Koizumi, Schuichi

2017-04-01

The pathophysiologies of nocturia (NOC) and nocturnal polyuria (NP) are multifactorial and their etiologies remain unclear in a large number of patients. Clock genes exist in most cells and organs, and the products of Clock regulate circadian rhythms as representative clock genes. Clock genes regulate lower urinary tract function, and a newly suggested concept is that abnormalities in clock genes cause lower urinary tract symptoms. In the present study, we investigated the voiding behavior of Clock mutant (Clock Δ19/Δ19 ) mice in order to determine the effects of clock genes on NOC/NP. Male C57BL/6 mice aged 8-12 weeks (WT) and male C57BL/6 Clock Δ19/Δ19 mice aged 8 weeks were used. They were bred under 12 hr light/dark conditions for 2 weeks and voiding behavior was investigated by measuring water intake volume, urine volume, urine volume/void, and voiding frequency in metabolic cages in the dark and light periods. No significant differences were observed in behavior patterns between Clock Δ19/Δ19 and WT mice. Clock Δ19/Δ19 mice showed greater voiding frequencies and urine volumes during the sleep phase than WT mice. The diurnal change in urine volume/void between the dark and light periods in WT mice was absent in Clock Δ19/Δ19 mice. Additionally, functional bladder capacity was significantly lower in Clock Δ19/Δ19 mice than in WT mice. We demonstrated that Clock Δ19/Δ19 mice showed the phenotype of NOC/NP. The Clock Δ19/Δ19 mouse may be used as an animal model of NOC and NP. Neurourol. Urodynam. 36:1034-1038, 2017. © 2016 Wiley Periodicals, Inc. © 2016 Wiley Periodicals, Inc.

Clock synchronisation experiment in India using symphonie satellite

Science.gov (United States)

Somayajulu, Y. V.; Mathur, B. S.; Banerjee, P.; Garg, S. C.; Singh, L.; Sood, P. C.; Tyagi, T. R.; Jain, C. L.; Kumar, K.

1979-01-01

A recent clock synchronization experiment between the National Physical Laboratory (NPL), New Delhi and Space Applications Center (SAC), Ahemedabad, in India via geostationary satellite symphonie 2, stationed at 49 E longitude, is reported. A two-way transmission using a microwave transponder considered to provide the greatest precision in synchronization of two remote clocks is described.

Sugars, the clock and transition to flowering

Directory of Open Access Journals (Sweden)

Mohammad Reza eBolouri Moghaddam

2013-02-01

Full Text Available Sugars do not only act as source of energy, but they also act as signals in plants. This mini review summarizes the emerging links between sucrose-mediated signaling and the cellular networks involved in flowering time control and defense. Cross-talks with gibberellin (GA and jasmonate (JA signaling pathways are highlighted. The circadian clock fulfills a crucial role at the heart of cellular networks and the bilateral relation between sugar signaling and the clock is discussed. It is proposed that important factors controlling plant growth (DELLAs, PIFs, invertases and trehalose- 6-phosphate or T6P might fulfill central roles in the transition to flowering as well. The emerging concept of ‘sweet immunity’, modulated by the clock, might at least partly rely on a sucrose-specific signaling pathway that needs further exploration.

A Faster Algorithm for Solving One-Clock Priced Timed Games

DEFF Research Database (Denmark)

Hansen, Thomas Dueholm; Ibsen-Jensen, Rasmus; Miltersen, Peter Bro

2013-01-01

previously known time bound for solving one-clock priced timed games was 2O(n2+m) , due to Rutkowski. For our improvement, we introduce and study a new algorithm for solving one-clock priced timed games, based on the sweep-line technique from computational geometry and the strategy iteration paradigm from......One-clock priced timed games is a class of two-player, zero-sum, continuous-time games that was defined and thoroughly studied in previous works. We show that one-clock priced timed games can be solved in time m 12 n n O(1), where n is the number of states and m is the number of actions. The best...

A Faster Algorithm for Solving One-Clock Priced Timed Games

DEFF Research Database (Denmark)

Hansen, Thomas Dueholm; Ibsen-Jensen, Rasmus; Miltersen, Peter Bro

2012-01-01

previously known time bound for solving one-clock priced timed games was 2^(O(n^2+m)), due to Rutkowski. For our improvement, we introduce and study a new algorithm for solving one-clock priced timed games, based on the sweep-line technique from computational geometry and the strategy iteration paradigm from......One-clock priced timed games is a class of two-player, zero-sum, continuous-time games that was defined and thoroughly studied in previous works. We show that one-clock priced timed games can be solved in time m 12^n n^(O(1)), where n is the number of states and m is the number of actions. The best...

Clock transport synchronisation and the dragging of inertial frames

International Nuclear Information System (INIS)

Rosenblum, Arnold

1987-01-01

It is shown that it is possible, by using the lack of synchronisation of clocks by clock transport synchronisation in circular orbits, to test for the dragging of inertial frames in Einstein's theory of general relativity. Possible experiments are discussed. (author)

Extrapolation of the FOM 1 MW free-electron maser to a multi-megawatt millimeter microwave source

NARCIS (Netherlands)

Caplan, M.; Valentini, M.; Verhoeven, A.; Urbanus, W.; Tulupov, A.

1997-01-01

A Free-Electron Maser is now under test at the FOM Institute (Rijnhuizen, Netherlands) with the goal of producing 1 MW long pulse to CW microwave output in the range 130-250 GHz with wall plug efficiencies of 60%. An extrapolated version of this device is proposed, which by scaling up beam current

Non-Metastatic Cutaneous Melanoma Induces Chronodisruption in Central and Peripheral Circadian Clocks.

Science.gov (United States)

de Assis, Leonardo Vinícius Monteiro; Moraes, Maria Nathália; Magalhães-Marques, Keila Karoline; Kinker, Gabriela Sarti; da Silveira Cruz-Machado, Sanseray; Castrucci, Ana Maria de Lauro

2018-04-03

The biological clock has received increasing interest due to its key role in regulating body homeostasis in a time-dependent manner. Cancer development and progression has been linked to a disrupted molecular clock; however, in melanoma, the role of the biological clock is largely unknown. We investigated the effects of the tumor on its micro- (TME) and macro-environments (TMaE) in a non-metastatic melanoma model. C57BL/6J mice were inoculated with murine B16-F10 melanoma cells and 2 weeks later the animals were euthanized every 6 h during 24 h. The presence of a localized tumor significantly impaired the biological clock of tumor-adjacent skin and affected the oscillatory expression of genes involved in light- and thermo-reception, proliferation, melanogenesis, and DNA repair. The expression of tumor molecular clock was significantly reduced compared to healthy skin but still displayed an oscillatory profile. We were able to cluster the affected genes using a human database and distinguish between primary melanoma and healthy skin. The molecular clocks of lungs and liver (common sites of metastasis), and the suprachiasmatic nucleus (SCN) were significantly affected by tumor presence, leading to chronodisruption in each organ. Taken altogether, the presence of non-metastatic melanoma significantly impairs the organism's biological clocks. We suggest that the clock alterations found in TME and TMaE could impact development, progression, and metastasis of melanoma; thus, making the molecular clock an interesting pharmacological target.

Non-Metastatic Cutaneous Melanoma Induces Chronodisruption in Central and Peripheral Circadian Clocks

Directory of Open Access Journals (Sweden)

Leonardo Vinícius Monteiro de Assis

2018-04-01

Full Text Available The biological clock has received increasing interest due to its key role in regulating body homeostasis in a time-dependent manner. Cancer development and progression has been linked to a disrupted molecular clock; however, in melanoma, the role of the biological clock is largely unknown. We investigated the effects of the tumor on its micro- (TME and macro-environments (TMaE in a non-metastatic melanoma model. C57BL/6J mice were inoculated with murine B16-F10 melanoma cells and 2 weeks later the animals were euthanized every 6 h during 24 h. The presence of a localized tumor significantly impaired the biological clock of tumor-adjacent skin and affected the oscillatory expression of genes involved in light- and thermo-reception, proliferation, melanogenesis, and DNA repair. The expression of tumor molecular clock was significantly reduced compared to healthy skin but still displayed an oscillatory profile. We were able to cluster the affected genes using a human database and distinguish between primary melanoma and healthy skin. The molecular clocks of lungs and liver (common sites of metastasis, and the suprachiasmatic nucleus (SCN were significantly affected by tumor presence, leading to chronodisruption in each organ. Taken altogether, the presence of non-metastatic melanoma significantly impairs the organism’s biological clocks. We suggest that the clock alterations found in TME and TMaE could impact development, progression, and metastasis of melanoma; thus, making the molecular clock an interesting pharmacological target.

Determination of global positioning system (GPS) receiver clock errors: impact on positioning accuracy

International Nuclear Information System (INIS)

Yeh, Ta-Kang; Hwang, Cheinway; Xu, Guochang; Wang, Chuan-Sheng; Lee, Chien-Chih

2009-01-01

Enhancing the positioning precision is the primary pursuit of global positioning system (GPS) users. To achieve this goal, most studies have focused on the relationship between GPS receiver clock errors and GPS positioning precision. This study utilizes undifferentiated phase data to calculate GPS clock errors and to compare with the frequency of cesium clock directly, to verify estimated clock errors by the method used in this paper. The frequency stability calculated from this paper (the indirect method) and measured from the National Standard Time and Frequency Laboratory (NSTFL) of Taiwan (the direct method) match to 1.5 × 10 −12 (the value from this study was smaller than that from NSTFL), suggesting that the proposed technique has reached a certain level of quality. The built-in quartz clocks in the GPS receivers yield relative frequency offsets that are 3–4 orders higher than those of rubidium clocks. The frequency stability of the quartz clocks is on average two orders worse than that of the rubidium clock. Using the rubidium clock instead of the quartz clock, the horizontal and vertical positioning accuracies were improved by 26–78% (0.6–3.6 mm) and 20–34% (1.3–3.0 mm), respectively, for a short baseline. These improvements are 7–25% (0.3–1.7 mm) and 11% (1.7 mm) for a long baseline. Our experiments show that the frequency stability of the clock, rather than relative frequency offset, is the governing factor of positioning accuracy

Strontium Optical Lattice Clock: In Quest of the Ultimate Performance

International Nuclear Information System (INIS)

Westergaard, Ph.G.

2010-10-01

This thesis presents the latest achievements regarding the Sr optical lattice clock experiment at LNESYRTE, Observatoire de Paris. After having described the general principles for optical lattice clocks and the operation of the clock in question, the emphasis is put on the features that have been added to the experiment since 2007. The most important new elements are an ultra-stable reference cavity for the clock laser, the development of a non-destructive detection technique, and the construction of a second Sr lattice clock. The ultra-stable cavity is constructed from a ULE spacer and fused silica mirrors and has shown a thermal noise floor at 6.5 * 10 -16 , placing it among the best in the world. The non-destructive detection is effectuated by a phase measurement of a weak probe beam that traverses the atoms placed in one arm of a Mach-Zender interferometer. The non-destructive aspect enables a recycling of the atoms from cycle to cycle which consequently increases the duty cycle, allowing for an increase of the stability of the clock. With these new tools the frequency stability is expected to be 2.2 * 10 -16 /√τ for an optimized sequence. The most recent comparisons between the two Sr clocks reach an accuracy level of 10 -16 after about 1000 s, and this way we have been able to characterize lattice related frequency shifts with an unprecedented accuracy. The measurements ensure a control of lattice related effects at the 10 -18 level even for trap depths as large as 50E r . (authors)

Light and the human circadian clock.

Science.gov (United States)

Roenneberg, Till; Kantermann, Thomas; Juda, Myriam; Vetter, Céline; Allebrandt, Karla V

2013-01-01

The circadian clock can only reliably fulfil its function if it is stably entrained. Most clocks use the light-dark cycle as environmental signal (zeitgeber) for this active synchronisation. How we think about clock function and entrainment has been strongly influenced by the early concepts of the field's pioneers, and the astonishing finding that circadian rhythms continue a self-sustained oscillation in constant conditions has become central to our understanding of entrainment.Here, we argue that we have to rethink these initial circadian dogmas to fully understand the circadian programme and how it entrains. Light is also the prominent zeitgeber for the human clock, as has been shown experimentally in the laboratory and in large-scale epidemiological studies in real life, and we hypothesise that social zeitgebers act through light entrainment via behavioural feedback loops (zeitnehmer). We show that human entrainment can be investigated in detail outside of the laboratory, by using the many 'experimental' conditions provided by the real world, such as daylight savings time, the 'forced synchrony' imposed by the introduction of time zones, or the fact that humans increasingly create their own light environment. The conditions of human entrainment have changed drastically over the past 100 years and have led to an increasing discrepancy between biological and social time (social jetlag). The increasing evidence that social jetlag has detrimental consequences for health suggests that shift-work is only an extreme form of circadian misalignment, and that the majority of the population in the industrialised world suffers from a similarly 'forced synchrony'.

Susceptibility of Redundant Versus Singular Clock Domains Implemented in SRAM-Based FPGA TMR Designs

Science.gov (United States)

Berg, Melanie D.; LaBel, Kenneth A.; Pellish, Jonathan

2016-01-01

We present the challenges that arise when using redundant clock domains due to their clock-skew. Radiation data show that a singular clock domain (DTMR) provides an improved TMR methodology for SRAM-based FPGAs over redundant clocks.

South African Journal of Geomatics - Vol 5, No 3 (2016)

African Journals Online (AJOL)

Analysis of the performance of hydrogen maser clocks at the Hartebeesthoek Radio Astronomy Observatory · EMAIL FREE FULL TEXT EMAIL FREE FULL TEXT DOWNLOAD FULL TEXT DOWNLOAD FULL TEXT. C Munghemezulu, L Combrinck, O.J. Botai, J Quick, 325-339. http://dx.doi.org/10.4314/sajg.v5i3.5 ...

Crime clocks and target performance maps

CSIR Research Space (South Africa)

Cooper, Antony K

1999-12-01

Full Text Available the period of analysis. Each segment of a pie chart represents a selected part of the day (eg: a two- or three-hour period) or a day of the week. The first and last segments in the day or week are then adjacent, ensuring that there is no artificial break... clocks We have also used crime clocks to map the proportion of crimes that occur during normal police working hours (07:00 to 16:00, Monday to Friday, in the case of the Johannesburg Area), against those that occur outside these hours. 3. Target...

A Group Neighborhood Average Clock Synchronization Protocol for Wireless Sensor Networks

Science.gov (United States)

Lin, Lin; Ma, Shiwei; Ma, Maode

2014-01-01

Clock synchronization is a very important issue for the applications of wireless sensor networks. The sensors need to keep a strict clock so that users can know exactly what happens in the monitoring area at the same time. This paper proposes a novel internal distributed clock synchronization solution using group neighborhood average. Each sensor node collects the offset and skew rate of the neighbors. Group averaging of offset and skew rate value are calculated instead of conventional point-to-point averaging method. The sensor node then returns compensated value back to the neighbors. The propagation delay is considered and compensated. The analytical analysis of offset and skew compensation is presented. Simulation results validate the effectiveness of the protocol and reveal that the protocol allows sensor networks to quickly establish a consensus clock and maintain a small deviation from the consensus clock. PMID:25120163

Daily rhythmicity of clock gene transcripts in atlantic cod fast skeletal muscle.

Directory of Open Access Journals (Sweden)

Carlo C Lazado

Full Text Available The classical notion of a centralized clock that governs circadian rhythmicity has been challenged with the discovery of peripheral oscillators that enable organisms to cope with daily changes in their environment. The present study aimed to identify the molecular clock components in Atlantic cod (Gadus morhua and to investigate their daily gene expression in fast skeletal muscle. Atlantic cod clock genes were closely related to their orthologs in teleosts and tetrapods. Synteny was conserved to varying degrees in the majority of the 18 clock genes examined. In particular, aryl hydrocarbon receptor nuclear translocator-like 2 (arntl2, RAR-related orphan receptor A (rora and timeless (tim displayed high degrees of conservation. Expression profiling during the early ontogenesis revealed that some transcripts were maternally transferred, namely arntl2, cryptochrome 1b and 2 (cry1b and cry2, and period 2a and 2b (per2a and per2b. Most clock genes were ubiquitously expressed in various tissues, suggesting the possible existence of multiple peripheral clock systems in Atlantic cod. In particular, they were all detected in fast skeletal muscle, with the exception of neuronal PAS (Per-Arnt-Single-minded domain-containing protein (npas1 and rora. Rhythmicity analysis revealed 8 clock genes with daily rhythmic expression, namely arntl2, circadian locomotor output cycles kaput (clock, npas2, cry2, cry3 per2a, nuclear receptor subfamily 1, group D, member 1 (nr1d1, and nr1d2a. Transcript levels of the myogenic genes myogenic factor 5 (myf5 and muscleblind-like 1 (mbnl1 strongly correlated with clock gene expression. This is the first study to unravel the molecular components of peripheral clocks in Atlantic cod. Taken together, our data suggest that the putative clock system in fast skeletal muscle of Atlantic cod has regulatory implications on muscle physiology, particularly in the expression of genes related to myogenesis.

A quantum analogy to the classical gravitomagnetic clock effect

Science.gov (United States)

Faruque, S. B.

2018-06-01

We present an approximation to the solution of Dirac equation in Schwarzschild field found through the use of Foldy-Wouthuysen Hamiltonian. We solve the equation for the positive energy states and found the frequencies by which the states oscillate. Difference of the periods of oscillation of the two states with two different total angular momentum quantum number j has an analogical form of the classical clock effect found in general relativity. But unlike the term that appears as clock effect in classical physics, here the term is quantized. Thus, we find a quantum analogue of the classical gravitomagnetic clock effect.

Clock-transport synchronisation for neutrino time-of-flight measurements

International Nuclear Information System (INIS)

Field, J.H.

2012-01-01

A method to synchronise, at the sub-nanosecond level, clocks used for neutrino time-of-flight measurements is proposed. Clocks situated near the neutrino source and target are compared with a moveable clock that is transported between them. The general-relativistic theory of the procedure was tested and verified in an experiment performed by Hafele and Keating in 1972. It is suggested that use of such a synchronisation method may contribute to a precise test of the Sagnac effect - a measured velocity greater than c - for neutrinos of the proposed LBNE beam between Fermilab and the Homestake mine. (orig.)

A method of high accuracy clock synchronization by frequency following with VCXO

International Nuclear Information System (INIS)

Ma Yichao; Wu Jie; Zhang Jie; Song Hongzhi; Kong Yang

2011-01-01

In this paper, the principle of the synchronous protocol of the IEEE1588 is analyzed, and the factors that affect the accuracy of synchronization is summarized. Through the hardware timer in a microcontroller, we give the exactly the time when a package is sent or received. So synchronization of the distributed clocks can reach 1 μs in this way. Another method to improve precision of the synchronization is to replace the traditional fixed frequency crystal of the slave device, which needs to follow up the master clock, by an adjustable VCXO. So it is possible to fine tune the frequency of the distributed clocks, and reduce the drift of clock, which shows great benefit for the clock synchronization. A test measurement shows the synchronization of distribute clocks can be better than 10 ns using this method, which is more accurate than the method realized by software. (authors)

Measurement of atomic-hydrogen spin-exchange parameters at 0.5 K using a cryogenic hydrogen maser

International Nuclear Information System (INIS)

Hayden, M.E.; Huerlimann, M.D.; Hardy, W.N.

1996-01-01

Using a cryogenic hydrogen maser, suitably modified to have electronic control of both the resonance frequency and the quality factor of the external cavity, we have measured a number of spin-exchange parameters for an atomic-hydrogen (H) gas at a temperature of 0.5 K. These results are relevant to the ultimate achievable frequency stability for cryogenic H masers and, when coupled with accurate calculations of the spin-exchange parameters, serve as a sensitive test of the H-H interatomic potentials. We find evidence for a frequency shift not predicted by semiclassical theories of spin exchange. In the context of a fully quantum mechanical hydrogen-atom spin-exchange theory [B. J. Verhaar et al., Phys. Rev. A 35, 3825 (1987) and J. M. V. A. Koelman et al., Phys. Rev. A 38, 3535 (1988)], this frequency shift is attributed to the influence of hyperfine interactions during spin-exchange collisions. Our findings are generally in agreement with these predictions; however, the sign of the hyperfine-induced frequency shift appears to differ from theory. copyright 1996 The American Physical Society

The Circadian Clock-controlled Transcriptome of Developing Soybean Seeds

Directory of Open Access Journals (Sweden)

Karen A. Hudson

2010-07-01

Full Text Available A number of metabolic and physiological processes in plants are controlled by the circadian clock, which enables a plant to anticipate daily changes in the environment. Relatively little is known about circadian rhythms in developing seeds, which may be important for determining the extent and timing of nutrient storage in grain. Microarray expression profiling was used to identify genes expressed in developing soybean ( seeds that are controlled by the circadian clock. Genes with predicted functions in protein synthesis, fatty acid metabolism, and photosynthesis totaling 1.8% of the mRNAs detected in seed were found to be expressed in a circadian rhythm. Known circadian and light-controlled promoter elements were identified as over-represented in the promoters of clock-controlled seed genes, with the over-represented elements varying according to the phase of circadian expression. A subset of circadian-regulated genes were found to be expressed in different phases in developing seeds with respect to leaves from the same plants, many of which have roles in photosynthesis and carbon metabolism. These results help to characterize the genes and processes in seeds that may be regulated by the circadian clock, and provide some insight into organ-specific phasing of clock controlled gene expression.

State-of-the-art of high power gyro-devices and free electron masers

International Nuclear Information System (INIS)

Thumm, M.

1993-10-01

At present, gyrotron oscillators are mainly used as high power millimeter wave sources for electron cyclotron resonance heating (ECRH) and diagnostics of magnetically confined plasmas for generation of energy by controlled thermonuclear fusion. 140 GHz gyrotrons with output power P out = 0.58 MW, pulse length τ = 2.0 s and efficiency η = 34% are commercially available. Diagnostic gyrotrons deliver P out = 40 kW with τ = 40 μs at frequencies up to 650 GHz (η ≥ 4%). Recently, gyrotron oscillators have also been successfully used in material processing and plasma chemistry. Such technological applications require gyrotrons with the following parameters: f ≥ 28 GHz, P out = 10-30 kW, CW, η ≥ 30%. This paper reports on achievements and problems related to the development of very high power mm-wave gyrotrons for long pulse or CW operation and describes the microwave technological pecularities of the different development steps. In addition, this work gives a short overview of the present development of gyrotrons for technological applications, quasi-optical gyrotrons, cyclotron autoresonance masers (CARMs), gyro-klystrons, gyro-TWT amplifiers, gyro-BWO's and free electron masers (FEMs). The most impressive FEM output parameters are: P out = 2 GW, τ = 20 ns, η = 13% at 140 GHz (LLNL) and P out = 15 kW, τ = 20 μs, η = 5% in the range from 120 to 900 GHz (UCSB). (orig.) [de

A ferroelectric electron gun in a free-electron maser experiment

International Nuclear Information System (INIS)

Einat, M.; Jerby, E.; Rosenman, G.

2002-01-01

An electron-gun based on a ferroelectric cathode is studied in a free-electron maser (FEM) experiment. In this gun, the electrons are separated from the cathode surface plasma, and are accelerated in two stages. The electron energy-spread is reduced sufficiently for an FEM operation in the microwave regime. A 14 keV, 1-2 A e-beam is obtained in a 0.1-2.1 μs pulse width. The pulse repetition frequency attains 3.1 MHz in ∼50% duty-cycle. This gun is implemented in an FEM oscillator experiment operating around 3 GHz. The paper presents experimental results and discusses the applicability of ferroelectric guns in free-electron laser devices

A ferroelectric electron gun in a free-electron maser experiment

CERN Document Server

Einat, M; Rosenman, G

2002-01-01

An electron-gun based on a ferroelectric cathode is studied in a free-electron maser (FEM) experiment. In this gun, the electrons are separated from the cathode surface plasma, and are accelerated in two stages. The electron energy-spread is reduced sufficiently for an FEM operation in the microwave regime. A 14 keV, 1-2 A e-beam is obtained in a 0.1-2.1 mu s pulse width. The pulse repetition frequency attains 3.1 MHz in approx 50% duty-cycle. This gun is implemented in an FEM oscillator experiment operating around 3 GHz. The paper presents experimental results and discusses the applicability of ferroelectric guns in free-electron laser devices.

Transportable Optical Lattice Clock with 7×10^{-17} Uncertainty.

Science.gov (United States)

Koller, S B; Grotti, J; Vogt, St; Al-Masoudi, A; Dörscher, S; Häfner, S; Sterr, U; Lisdat, Ch

2017-02-17

We present a transportable optical clock (TOC) with ^{87}Sr. Its complete characterization against a stationary lattice clock resulted in a systematic uncertainty of 7.4×10^{-17}, which is currently limited by the statistics of the determination of the residual lattice light shift, and an instability of 1.3×10^{-15}/sqrt[τ] with an averaging time τ in seconds. Measurements confirm that the systematic uncertainty can be reduced to below the design goal of 1×10^{-17}. To our knowledge, these are the best uncertainties and instabilities reported for any transportable clock to date. For autonomous operation, the TOC has been installed in an air-conditioned car trailer. It is suitable for chronometric leveling with submeter resolution as well as for intercontinental cross-linking of optical clocks, which is essential for a redefinition of the International System of Units (SI) second. In addition, the TOC will be used for high precision experiments for fundamental science that are commonly tied to precise frequency measurements and its development is an important step to space-borne optical clocks.

Transportable Optical Lattice Clock with 7 ×10-17 Uncertainty

Science.gov (United States)

Koller, S. B.; Grotti, J.; Vogt, St.; Al-Masoudi, A.; Dörscher, S.; Häfner, S.; Sterr, U.; Lisdat, Ch.

2017-02-01

We present a transportable optical clock (TOC) with Sr 87 . Its complete characterization against a stationary lattice clock resulted in a systematic uncertainty of 7.4 ×10-17, which is currently limited by the statistics of the determination of the residual lattice light shift, and an instability of 1.3 ×10-15/√{τ } with an averaging time τ in seconds. Measurements confirm that the systematic uncertainty can be reduced to below the design goal of 1 ×10-17. To our knowledge, these are the best uncertainties and instabilities reported for any transportable clock to date. For autonomous operation, the TOC has been installed in an air-conditioned car trailer. It is suitable for chronometric leveling with submeter resolution as well as for intercontinental cross-linking of optical clocks, which is essential for a redefinition of the International System of Units (SI) second. In addition, the TOC will be used for high precision experiments for fundamental science that are commonly tied to precise frequency measurements and its development is an important step to space-borne optical clocks.

Differential maturation of rhythmic clock gene expression during early development in medaka (Oryzias latipes).

Science.gov (United States)

Cuesta, Ines H; Lahiri, Kajori; Lopez-Olmeda, Jose Fernando; Loosli, Felix; Foulkes, Nicholas S; Vallone, Daniela

2014-05-01

One key challenge for the field of chronobiology is to identify how circadian clock function emerges during early embryonic development. Teleosts such as the zebrafish are ideal models for studying circadian clock ontogeny since the entire process of development occurs ex utero in an optically transparent chorion. Medaka (Oryzias latipes) represents another powerful fish model for exploring early clock function with, like the zebrafish, many tools available for detailed genetic analysis. However, to date there have been no reports documenting circadian clock gene expression during medaka development. Here we have characterized the expression of key clock genes in various developmental stages and in adult tissues of medaka. As previously reported for other fish, light dark cycles are required for the emergence of clock gene expression rhythms in this species. While rhythmic expression of per and cry genes is detected very early during development and seems to be light driven, rhythmic clock and bmal expression appears much later around hatching time. Furthermore, the maturation of clock function seems to correlate with the appearance of rhythmic expression of these positive elements of the clock feedback loop. By accelerating development through elevated temperatures or by artificially removing the chorion, we show an earlier onset of rhythmicity in clock and bmal expression. Thus, differential maturation of key elements of the medaka clock mechanism depends on the developmental stage and the presence of the chorion.

A parametric investigation on the cyclotron maser instability driven by ring-beam electrons with intrinsic Alfvén waves

Science.gov (United States)

Tong, Zi-Jin; Wang, Chuan-Bing; Zhang, Pei-Jin; Liu, Jin

2017-05-01

The electron-cyclotron maser is a process that generates the intense and coherent radio emission in the plasma. In this paper, we present a comprehensive parametric investigation on the electron-cyclotron-maser instability driven by non-thermal ring-beam electrons with intrinsic Alfvén waves, which pervade the solar atmosphere and interplanetary space. It is found that both forward propagating and backward propagating waves can be excited in the fast ordinary (O) and extraordinary (X) electromagnetic modes. The growth rates of X1 mode are almost always weakened by Alfvén waves. The average pitch-angle ϕ 0 of electrons is a key parameter for the effect of Alfvén waves on the growth rate of modes O1, O2, and X2. For a beam-dominated electron distribution ( ϕ 0 ≲ 30 ° ), the growth rates of the maser instability for O1, O2, and X2 modes are enhanced with the increase of the Alfvén wave energy density. In other conditions, the growth rates of O1, O2, and X2 modes weakened with the increasing Alfvén wave intensity, except that the growth of the O1 mode may also be enhanced by Alfvén waves for a ring distribution. The results may be important for us in analyzing the mechanism of radio bursts with various fine structures observed in space and astrophysical plasmas.

A Group Neighborhood Average Clock Synchronization Protocol for Wireless Sensor Networks

Directory of Open Access Journals (Sweden)

Lin Lin

2014-08-01

Full Text Available Clock synchronization is a very important issue for the applications of wireless sensor networks. The sensors need to keep a strict clock so that users can know exactly what happens in the monitoring area at the same time. This paper proposes a novel internal distributed clock synchronization solution using group neighborhood average. Each sensor node collects the offset and skew rate of the neighbors. Group averaging of offset and skew rate value are calculated instead of conventional point-to-point averaging method. The sensor node then returns compensated value back to the neighbors. The propagation delay is considered and compensated. The analytical analysis of offset and skew compensation is presented. Simulation results validate the effectiveness of the protocol and reveal that the protocol allows sensor networks to quickly establish a consensus clock and maintain a small deviation from the consensus clock.

Research on the Method of Noise Error Estimation of Atomic Clocks

Science.gov (United States)

Song, H. J.; Dong, S. W.; Li, W.; Zhang, J. H.; Jing, Y. J.

2017-05-01

The simulation methods of different noises of atomic clocks are given. The frequency flicker noise of atomic clock is studied by using the Markov process theory. The method for estimating the maximum interval error of the frequency white noise is studied by using the Wiener process theory. Based on the operation of 9 cesium atomic clocks in the time frequency reference laboratory of NTSC (National Time Service Center), the noise coefficients of the power-law spectrum model are estimated, and the simulations are carried out according to the noise models. Finally, the maximum interval error estimates of the frequency white noises generated by the 9 cesium atomic clocks have been acquired.

Micro Mercury Ion Clock (MMIC)

Data.gov (United States)

National Aeronautics and Space Administration — Demonstrate micro clock based on trapped Hg ions with more than 10x size reduction and power; Fractional frequency stability at parts per 1014 level, adequate for...

Molecular clock in neutral protein evolution

Directory of Open Access Journals (Sweden)

Wilke Claus O

2004-08-01

Full Text Available Abstract Background A frequent observation in molecular evolution is that amino-acid substitution rates show an index of dispersion (that is, ratio of variance to mean substantially larger than one. This observation has been termed the overdispersed molecular clock. On the basis of in silico protein-evolution experiments, Bastolla and coworkers recently proposed an explanation for this observation: Proteins drift in neutral space, and can temporarily get trapped in regions of substantially reduced neutrality. In these regions, substitution rates are suppressed, which results in an overall substitution process that is not Poissonian. However, the simulation method of Bastolla et al. is representative only for cases in which the product of mutation rate μ and population size Ne is small. How the substitution process behaves when μNe is large is not known. Results Here, I study the behavior of the molecular clock in in silico protein evolution as a function of mutation rate and population size. I find that the index of dispersion decays with increasing μNe, and approaches 1 for large μNe . This observation can be explained with the selective pressure for mutational robustness, which is effective when μNe is large. This pressure keeps the population out of low-neutrality traps, and thus steadies the ticking of the molecular clock. Conclusions The molecular clock in neutral protein evolution can fall into two distinct regimes, a strongly overdispersed one for small μNe, and a mostly Poissonian one for large μNe. The former is relevant for the majority of organisms in the plant and animal kingdom, and the latter may be relevant for RNA viruses.

A proportional integral estimator-based clock synchronization protocol for wireless sensor networks.

Science.gov (United States)

Yang, Wenlun; Fu, Minyue

2017-11-01

Clock synchronization is an issue of vital importance in applications of WSNs. This paper proposes a proportional integral estimator-based protocol (EBP) to achieve clock synchronization for wireless sensor networks. As each local clock skew gradually drifts, synchronization accuracy will decline over time. Compared with existing consensus-based approaches, the proposed synchronization protocol improves synchronization accuracy under time-varying clock skews. Moreover, by restricting synchronization error of clock skew into a relative small quantity, it could reduce periodic re-synchronization frequencies. At last, a pseudo-synchronous implementation for skew compensation is introduced as synchronous protocol is unrealistic in practice. Numerical simulations are shown to illustrate the performance of the proposed protocol. Copyright © 2017 ISA. Published by Elsevier Ltd. All rights reserved.

Author Details

African Journals Online (AJOL)

Botai, O.J.. Vol 5, No 3 (2016) - Articles Analysis of the performance of hydrogen maser clocks at the Hartebeesthoek Radio Astronomy Observatory Abstract PDF. ISSN: 2225-8531. AJOL African Journals Online. HOW TO USE AJOL... for Researchers · for Librarians · for Authors · FAQ's · More about AJOL · AJOL's Partners ...

Direct Repression of Evening Genes by CIRCADIAN CLOCK-ASSOCIATED1 in the Arabidopsis Circadian Clock.

Science.gov (United States)

Kamioka, Mari; Takao, Saori; Suzuki, Takamasa; Taki, Kyomi; Higashiyama, Tetsuya; Kinoshita, Toshinori; Nakamichi, Norihito

2016-03-01

The circadian clock is a biological timekeeping system that provides organisms with the ability to adapt to day-night cycles. Timing of the expression of four members of the Arabidopsis thaliana PSEUDO-RESPONSE REGULATOR(PRR) family is crucial for proper clock function, and transcriptional control of PRRs remains incompletely defined. Here, we demonstrate that direct regulation of PRR5 by CIRCADIAN CLOCK-ASSOCIATED1 (CCA1) determines the repression state of PRR5 in the morning. Chromatin immunoprecipitation followed by deep sequencing (ChIP-seq) analyses indicated that CCA1 associates with three separate regions upstream of PRR5 CCA1 and its homolog LATE ELONGATED HYPOCOTYL (LHY) suppressed PRR5 promoter activity in a transient assay. The regions bound by CCA1 in the PRR5 promoter gave rhythmic patterns with troughs in the morning, when CCA1 and LHY are at high levels. Furthermore,ChIP-seq revealed that CCA1 associates with at least 449 loci with 863 adjacent genes. Importantly, this gene set contains genes that are repressed but upregulated incca1 lhy double mutants in the morning. This study shows that direct binding by CCA1 in the morning provides strong repression of PRR5, and repression by CCA1 also temporally regulates an evening-expressed gene set that includes PRR5. © 2016 American Society of Plant Biologists. All rights reserved.

Fault-tolerant clock synchronization in distributed systems

Science.gov (United States)

Ramanathan, Parameswaran; Shin, Kang G.; Butler, Ricky W.

1990-01-01

Existing fault-tolerant clock synchronization algorithms are compared and contrasted. These include the following: software synchronization algorithms, such as convergence-averaging, convergence-nonaveraging, and consistency algorithms, as well as probabilistic synchronization; hardware synchronization algorithms; and hybrid synchronization. The worst-case clock skews guaranteed by representative algorithms are compared, along with other important aspects such as time, message, and cost overhead imposed by the algorithms. More recent developments such as hardware-assisted software synchronization and algorithms for synchronizing large, partially connected distributed systems are especially emphasized.

Test of Special Relativity Using a Fiber Network of Optical Clocks.

Science.gov (United States)

Delva, P; Lodewyck, J; Bilicki, S; Bookjans, E; Vallet, G; Le Targat, R; Pottie, P-E; Guerlin, C; Meynadier, F; Le Poncin-Lafitte, C; Lopez, O; Amy-Klein, A; Lee, W-K; Quintin, N; Lisdat, C; Al-Masoudi, A; Dörscher, S; Grebing, C; Grosche, G; Kuhl, A; Raupach, S; Sterr, U; Hill, I R; Hobson, R; Bowden, W; Kronjäger, J; Marra, G; Rolland, A; Baynes, F N; Margolis, H S; Gill, P

2017-06-02

Phase compensated optical fiber links enable high accuracy atomic clocks separated by thousands of kilometers to be compared with unprecedented statistical resolution. By searching for a daily variation of the frequency difference between four strontium optical lattice clocks in different locations throughout Europe connected by such links, we improve upon previous tests of time dilation predicted by special relativity. We obtain a constraint on the Robertson-Mansouri-Sexl parameter |α|≲1.1×10^{-8}, quantifying a violation of time dilation, thus improving by a factor of around 2 the best known constraint obtained with Ives-Stilwell type experiments, and by 2 orders of magnitude the best constraint obtained by comparing atomic clocks. This work is the first of a new generation of tests of fundamental physics using optical clocks and fiber links. As clocks improve, and as fiber links are routinely operated, we expect that the tests initiated in this Letter will improve by orders of magnitude in the near future.

Cell-permeable Circadian Clock Proteins

National Research Council Canada - National Science Library

Johnson, Carl

2002-01-01

.... These 'biological clocks' are important to human physiology. For example, psychiatric and medical studies have shown that circadian rhythmicity is involved in some forms of depressive illness, 'jet lag', drug tolerance/efficacy, memory, and insomnia...

Pittendrigh: The Darwinian Clock-Watcher

Indian Academy of Sciences (India)

to our current understanding of how timing systems work in living organisms. .... to periodic factors in the geophysical environment. He postulated .... clocks against temperature, nutrition and light, while the latter needs maintenance of a stable.

The Eddington Ratio of H2O Maser Host AGN Q. Guo1, J. S. Zhang2 ...

Indian Academy of Sciences (India)

tion rate and on the efficiency for converting gravitational energy into radiation. The. Eddington ratio, i.e., ratio of the bolometric luminosity and Eddington luminosity, is very important to constrain predictions of theoretical models. Observations demon- strate that most of the H2O maser spots are located in the nuclear region ...

Correction of clock errors in seismic data using noise cross-correlations

Science.gov (United States)

Hable, Sarah; Sigloch, Karin; Barruol, Guilhem; Hadziioannou, Céline

2017-04-01

Correct and verifiable timing of seismic records is crucial for most seismological applications. For seismic land stations, frequent synchronization of the internal station clock with a GPS signal should ensure accurate timing, but loss of GPS synchronization is a common occurrence, especially for remote, temporary stations. In such cases, retrieval of clock timing has been a long-standing problem. The same timing problem applies to Ocean Bottom Seismometers (OBS), where no GPS signal can be received during deployment and only two GPS synchronizations can be attempted upon deployment and recovery. If successful, a skew correction is usually applied, where the final timing deviation is interpolated linearly across the entire operation period. If GPS synchronization upon recovery fails, then even this simple and unverified, first-order correction is not possible. In recent years, the usage of cross-correlation functions (CCFs) of ambient seismic noise has been demonstrated as a clock-correction method for certain network geometries. We demonstrate the great potential of this technique for island stations and OBS that were installed in the course of the Réunion Hotspot and Upper Mantle - Réunions Unterer Mantel (RHUM-RUM) project in the western Indian Ocean. Four stations on the island La Réunion were affected by clock errors of up to several minutes due to a missing GPS signal. CCFs are calculated for each day and compared with a reference cross-correlation function (RCF), which is usually the average of all CCFs. The clock error of each day is then determined from the measured shift between the daily CCFs and the RCF. To improve the accuracy of the method, CCFs are computed for several land stations and all three seismic components. Averaging over these station pairs and their 9 component pairs reduces the standard deviation of the clock errors by a factor of 4 (from 80 ms to 20 ms). This procedure permits a continuous monitoring of clock errors where small clock

Clock domain crossing modules for OCP-style read/write interfaces

DEFF Research Database (Denmark)

Herlev, Mathias; Sparsø, Jens

The open core protocol (OCP) is an openly licensed, configurable, and scalable interface protocol for on-chip subsystem communications. The protocol defines read and write transactions from a master towards a slave across a point-to-point connection and the protocol assumes a single common clock....... This paper presents the design of two OCP clock domain crossing interface modules, that can be used to construct systems with multiple clock domains. One module (called OCPio) supports a single word read-write interface and the other module (called OCPburst) supports a four word burst read-write interface......-style read-write transaction interfaces. An OCP interface typically has control signals related to both the master issuing a read or write request and the slave producing a response. If all these control signals are passed across the clock domain boundary and synchronized it may add significant latency...

Circadian expression of clock genes and clock-controlled genes in the rat retina

NARCIS (Netherlands)

Kamphuis, Willem; Cailotto, Cathy; Dijk, Frederike; Bergen, Arthur; Buijs, Ruud M.

2005-01-01

The circadian expression patterns of genes encoding for proteins that make up the core of the circadian clock were measured in rat retina using real-time quantitative PCR (qPCR). Transcript levels of several genes previously used for normalization of qPCR assays were determined and the effect of

Highly Accurate Timestamping for Ethernet-Based Clock Synchronization

OpenAIRE

Loschmidt, Patrick; Exel, Reinhard; Gaderer, Georg

2012-01-01

It is not only for test and measurement of great importance to synchronize clocks of networked devices to timely coordinate data acquisition. In this context the seek for high accuracy in Ethernet-based clock synchronization has been significantly supported by enhancements to the Network Time Protocol (NTP) and the introduction of the Precision Time Protocol (PTP). The latter was even applied to instrumentation and measurement applications through the introduction of LXI....

Tracing major structures of the inner Galaxy with 6.7-GHz methanol masers

Directory of Open Access Journals (Sweden)

Pestalozzi M.

2012-02-01

Full Text Available Through analysis of correlations within the longitude-velocity distribution of 6.7-GHz methanol masers, we identify density enhancements indicative of large-scale regions of enhanced star formation. In the context of the inner structure of our Galaxy these are interpreted as the starting points of the spiral arms and the interaction of the long Galactic bar with the 3–kpc arms. Signatures of a continuous 3–kpc arm structure are seen including a prominent tangent at –22° Galactic longitude.

Evaluating the Autonomy of the Drosophila Circadian Clock in Dissociated Neuronal Culture.

Science.gov (United States)

Sabado, Virginie; Vienne, Ludovic; Nagoshi, Emi

2017-01-01

Circadian behavioral rhythms offer an excellent model to study intricate interactions between the molecular and neuronal mechanisms of behavior. In mammals, pacemaker neurons in the suprachiasmatic nucleus (SCN) generate rhythms cell-autonomously, which are synchronized by the network interactions within the circadian circuit to drive behavioral rhythms. However, whether this principle is universal to circadian systems in animals remains unanswered. Here, we examined the autonomy of the Drosophila circadian clock by monitoring transcriptional and post-transcriptional rhythms of individual clock neurons in dispersed culture with time-lapse microscopy. Expression patterns of the transcriptional reporter show that CLOCK/CYCLE (CLK/CYC)-mediated transcription is constantly active in dissociated clock neurons. In contrast, the expression profile of the post-transcriptional reporter indicates that PERIOD (PER) protein levels fluctuate and ~10% of cells display rhythms in PER levels with periods in the circadian range. Nevertheless, PER and TIM are enriched in the cytoplasm and no periodic PER nuclear accumulation was observed. These results suggest that repression of CLK/CYC-mediated transcription by nuclear PER is impaired, and thus the negative feedback loop of the molecular clock is incomplete in isolated clock neurons. We further demonstrate that, by pharmacological assays using the non-amidated form of neuropeptide pigment-dispersing factor (PDF), which could be specifically secreted from larval LNvs and adult s-LNvs, downstream events of the PDF signaling are partly impaired in dissociated larval clock neurons. Although non-amidated PDF is likely to be less active than the amidated one, these results point out the possibility that alteration in PDF downstream signaling may play a role in dampening of molecular rhythms in isolated clock neurons. Taken together, our results suggest that Drosophila clocks are weak oscillators that need to be in the intact circadian

Evaluating the Autonomy of the Drosophila Circadian Clock in Dissociated Neuronal Culture

Directory of Open Access Journals (Sweden)

Virginie Sabado

2017-10-01

Full Text Available Circadian behavioral rhythms offer an excellent model to study intricate interactions between the molecular and neuronal mechanisms of behavior. In mammals, pacemaker neurons in the suprachiasmatic nucleus (SCN generate rhythms cell-autonomously, which are synchronized by the network interactions within the circadian circuit to drive behavioral rhythms. However, whether this principle is universal to circadian systems in animals remains unanswered. Here, we examined the autonomy of the Drosophila circadian clock by monitoring transcriptional and post-transcriptional rhythms of individual clock neurons in dispersed culture with time-lapse microscopy. Expression patterns of the transcriptional reporter show that CLOCK/CYCLE (CLK/CYC-mediated transcription is constantly active in dissociated clock neurons. In contrast, the expression profile of the post-transcriptional reporter indicates that PERIOD (PER protein levels fluctuate and ~10% of cells display rhythms in PER levels with periods in the circadian range. Nevertheless, PER and TIM are enriched in the cytoplasm and no periodic PER nuclear accumulation was observed. These results suggest that repression of CLK/CYC-mediated transcription by nuclear PER is impaired, and thus the negative feedback loop of the molecular clock is incomplete in isolated clock neurons. We further demonstrate that, by pharmacological assays using the non-amidated form of neuropeptide pigment-dispersing factor (PDF, which could be specifically secreted from larval LNvs and adult s-LNvs, downstream events of the PDF signaling are partly impaired in dissociated larval clock neurons. Although non-amidated PDF is likely to be less active than the amidated one, these results point out the possibility that alteration in PDF downstream signaling may play a role in dampening of molecular rhythms in isolated clock neurons. Taken together, our results suggest that Drosophila clocks are weak oscillators that need to be in the

Circadian Clock Dysfunction and Psychiatric Disease: Could Fruit Flies have a Say?

Science.gov (United States)

Zordan, Mauro Agostino; Sandrelli, Federica

2015-01-01

There is evidence of a link between the circadian system and psychiatric diseases. Studies in humans and mammals suggest that environmental and/or genetic disruption of the circadian system leads to an increased liability to psychiatric disease. Disruption of clock genes and/or the clock network might be related to the etiology of these pathologies; also, some genes, known for their circadian clock functions, might be associated to mental illnesses through clock-independent pleiotropy. Here, we examine the features which we believe make Drosophila melanogaster a model apt to study the role of the circadian clock in psychiatric disease. Despite differences in the organization of the clock system, the molecular architecture of the Drosophila and mammalian circadian oscillators are comparable and many components are evolutionarily related. In addition, Drosophila has a rather complex nervous system, which shares much at the cell and neurobiological level with humans, i.e., a tripartite brain, the main neurotransmitter systems, and behavioral traits: circadian behavior, learning and memory, motivation, addiction, social behavior. There is evidence that the Drosophila brain shares some homologies with the vertebrate cerebellum, basal ganglia, and hypothalamus-pituitary-adrenal axis, the dysfunctions of which have been tied to mental illness. We discuss Drosophila in comparison to mammals with reference to the: organization of the brain and neurotransmitter systems; architecture of the circadian clock; clock-controlled behaviors. We sum up current knowledge on behavioral endophenotypes, which are amenable to modeling in flies, such as defects involving sleep, cognition, or social interactions, and discuss the relationship of the circadian system to these traits. Finally, we consider if Drosophila could be a valuable asset to understand the relationship between circadian clock malfunction and psychiatric disease.

Circadian clock dysfunction and psychiatric disease: could fruit flies have a say?

Directory of Open Access Journals (Sweden)

Mauro Agostino Zordan

2015-04-01

Full Text Available There is evidence of a link between the circadian system and psychiatric diseases. Studies in humans and mammals suggest that environmental and/or genetic disruption of the circadian system lead to an increased liability to psychiatric disease. Disruption of clock genes and/or the clock network might be related to the etiology of these pathologies; also, some genes, known for their circadian clock functions, might be associated to mental illnesses through clock-independent pleiotropy. Here we examine the features which we believe make Drosophila melanogaster a model apt to study the role of the circadian clock in psychiatric disease. Despite differences in the organization of the clock system, the molecular architecture of the Drosophila and mammalian circadian oscillators are comparable and many components are evolutionarily related. In addition, Drosophila has a rather complex nervous system, which shares much at the cell and neurobiological level with humans, i.e. a tripartite brain, the main neurotransmitter systems, and behavioral traits: circadian behavior, learning and memory, motivation, addiction, social behavior. There is evidence that the Drosophila brain shares some homologies with the vertebrate cerebellum, basal ganglia and hypothalamus-pituitary-adrenal axis, the dysfunctions of which have been tied to mental illness. We discuss Drosophila in comparison to mammals with reference to the: organization of the brain and neurotransmitter systems; architecture of the circadian clock; clock-controlled behaviors. We sum up current knowledge on behavioral endophenotypes which are amenable to modeling in flies, such as defects involving sleep, cognition, or social interactions and discuss the relationship of the circadian system to these traits. Finally, we consider if Drosophila could be a valuable asset to understand the relationship between circadian clock malfunction and psychiatric disease.

Central and peripheral circadian clocks and their role in Alzheimer's disease

Directory of Open Access Journals (Sweden)

Ruchi Chauhan

2017-10-01

Full Text Available Molecular and cellular oscillations constitute an internal clock that tracks the time of day and permits organisms to optimize their behaviour and metabolism to suit the daily demands they face. The workings of this internal clock become impaired with age. In this review, we discuss whether such age-related impairments in the circadian clock interact with age-related neurodegenerative disorders, such as Alzheimer's disease. Findings from mouse and fly models of Alzheimer's disease have accelerated our understanding of the interaction between neurodegeneration and circadian biology. These models show that neurodegeneration likely impairs circadian rhythms either by damaging the central clock or by blocking its communication with other brain areas and with peripheral tissues. The consequent sleep and metabolic deficits could enhance the susceptibility of the brain to further degenerative processes. Thus, circadian dysfunction might be both a cause and an effect of neurodegeneration. We also discuss the primary role of light in the entrainment of the central clock and describe important, alternative time signals, such as food, that play a role in entraining central and peripheral circadian clocks. Finally, we propose how these recent insights could inform efforts to develop novel therapeutic approaches to re-entrain arrhythmic individuals with neurodegenerative disease.

System and method for clock synchronization and position determination using entangled photon pairs

Science.gov (United States)

Shih, Yanhua (Inventor)

2010-01-01

A system and method for clock synchronization and position determination using entangled photon pairs is provided. The present invention relies on the measurement of the second order correlation function of entangled states. Photons from an entangled photon source travel one-way to the clocks to be synchronized. By analyzing photon registration time histories generated at each clock location, the entangled states allow for high accuracy clock synchronization as well as high accuracy position determination.

Chaotic map based key agreement with/out clock synchronization

International Nuclear Information System (INIS)

Han, S.; Chang, E.

2009-01-01

In order to address Bergamo et al.'s attack, Xiao et al. proposed a key agreement protocol using chaotic maps. Han then presented three attacks on Xiao et al.'s protocol. To enhance the security of key agreement based on chaotic maps, Chang et al. proposed a new key agreement using passphrase, which works in clock synchronization environment. However, their protocol still has some issues: one is its passphrase is not easy to remember and much longer than password; the second one is it cannot resist guessing attack if the constructed passphrase is easy to remember and also has already existed in some rational dictionaries; the third one is it cannot work without clock synchronization. In this paper, we will present two different key agreement protocols, which can resist guessing attack. The first one works in clock synchronization environment. The second one can work without clock synchronization. They both use authenticated password for secure communications. The protocols are secure against replaying attacks and a shared session key can be established.

All-optical clock recovery of NRZ-DPSK signals using optical resonator-type filters

DEFF Research Database (Denmark)

Peucheret, Christophe; Seoane, Jorge; Ji, Hua

2009-01-01

It is shown how introducing a limited rise time to the driving signal enables all-optical clock recovery of NRZ-DPSK signals generated using a phase modulator. A Fabry-Perot filter is used to generate the optical clock.......It is shown how introducing a limited rise time to the driving signal enables all-optical clock recovery of NRZ-DPSK signals generated using a phase modulator. A Fabry-Perot filter is used to generate the optical clock....

29 CFR 778.204 - “Clock pattern” premium pay.

Science.gov (United States)

2010-07-01

... 29 Labor 3 2010-07-01 2010-07-01 false âClock patternâ premium pay. 778.204 Section 778.204 Labor... Excluded From the âRegular Rateâ Extra Compensation Paid for Overtime § 778.204 “Clock pattern” premium pay... pursuance of an applicable employment contract or collective bargaining agreement,” and the rates of pay and...

Regulation of behavioral circadian rhythms and clock protein PER1 by the deubiquitinating enzyme USP2

Directory of Open Access Journals (Sweden)

Yaoming Yang

2012-06-01

Endogenous 24-hour rhythms are generated by circadian clocks located in most tissues. The molecular clock mechanism is based on feedback loops involving clock genes and their protein products. Post-translational modifications, including ubiquitination, are important for regulating the clock feedback mechanism. Previous work has focused on the role of ubiquitin ligases in the clock mechanism. Here we show a role for the rhythmically-expressed deubiquitinating enzyme ubiquitin specific peptidase 2 (USP2 in clock function. Mice with a deletion of the Usp2 gene (Usp2 KO display a longer free-running period of locomotor activity rhythms and altered responses of the clock to light. This was associated with altered expression of clock genes in synchronized Usp2 KO mouse embryonic fibroblasts and increased levels of clock protein PERIOD1 (PER1. USP2 can be coimmunoprecipitated with several clock proteins but directly interacts specifically with PER1 and deubiquitinates it. Interestingly, this deubiquitination does not alter PER1 stability. Taken together, our results identify USP2 as a new core component of the clock machinery and demonstrate a role for deubiquitination in the regulation of the circadian clock, both at the level of the core pacemaker and its response to external cues.

Clock gene modulates roles of OXTR and AVPR1b genes in prosociality.

Directory of Open Access Journals (Sweden)

Haipeng Ci

Full Text Available BACKGROUND: The arginine vasopressin receptor (AVPR and oxytocin receptor (OXTR genes have been demonstrated to contribute to prosocial behavior. Recent research has focused on the manner by which these simple receptor genes influence prosociality, particularly with regard to the AVP system, which is modulated by the clock gene. The clock gene is responsible for regulating the human biological clock, affecting sleep, emotion and behavior. The current study examined in detail whether the influences of the OXTR and AVPR1b genes on prosociality are dependent on the clock gene. METHODOLOGY/PRINCIPAL FINDINGS: This study assessed interactions between the clock gene (rs1801260, rs6832769 and the OXTR (rs1042778, rs237887 and AVPR1b (rs28373064 genes in association with individual differences in prosociality in healthy male Chinese subjects (n = 436. The Prosocial Tendencies Measure (PTM-R was used to assess prosociality. Participants carrying both the GG/GA variant of AVPR1b rs28373064 and the AA variant of clock rs6832769 showed the highest scores on the Emotional PTM. Carriers of both the T allele of OXTR rs1042778 and the C allele of clock rs1801260 showed the lowest total PTM scores compared with the other groups. CONCLUSIONS: The observed interaction effects provide converging evidence that the clock gene and OXT/AVP systems are intertwined and contribute to human prosociality.

Clock gene modulates roles of OXTR and AVPR1b genes in prosociality.

Science.gov (United States)

Ci, Haipeng; Wu, Nan; Su, Yanjie

2014-01-01

The arginine vasopressin receptor (AVPR) and oxytocin receptor (OXTR) genes have been demonstrated to contribute to prosocial behavior. Recent research has focused on the manner by which these simple receptor genes influence prosociality, particularly with regard to the AVP system, which is modulated by the clock gene. The clock gene is responsible for regulating the human biological clock, affecting sleep, emotion and behavior. The current study examined in detail whether the influences of the OXTR and AVPR1b genes on prosociality are dependent on the clock gene. This study assessed interactions between the clock gene (rs1801260, rs6832769) and the OXTR (rs1042778, rs237887) and AVPR1b (rs28373064) genes in association with individual differences in prosociality in healthy male Chinese subjects (n = 436). The Prosocial Tendencies Measure (PTM-R) was used to assess prosociality. Participants carrying both the GG/GA variant of AVPR1b rs28373064 and the AA variant of clock rs6832769 showed the highest scores on the Emotional PTM. Carriers of both the T allele of OXTR rs1042778 and the C allele of clock rs1801260 showed the lowest total PTM scores compared with the other groups. The observed interaction effects provide converging evidence that the clock gene and OXT/AVP systems are intertwined and contribute to human prosociality.

Noise-Induced Synchronization among Sub-RF CMOS Analog Oscillators for Skew-Free Clock Distribution

Science.gov (United States)

Utagawa, Akira; Asai, Tetsuya; Hirose, Tetsuya; Amemiya, Yoshihito

We present on-chip oscillator arrays synchronized by random noises, aiming at skew-free clock distribution on synchronous digital systems. Nakao et al. recently reported that independent neural oscillators can be synchronized by applying temporal random impulses to the oscillators [1], [2]. We regard neural oscillators as independent clock sources on LSIs; i. e., clock sources are distributed on LSIs, and they are forced to synchronize through the use of random noises. We designed neuron-based clock generators operating at sub-RF region (CMOS implementation with 0.25-μm CMOS parameters. Through circuit simulations, we demonstrate that i) the clock generators are certainly synchronized by pseudo-random noises and ii) clock generators exhibited phase-locked oscillations even if they had small device mismatches.

Clock distribution system for digital computers

International Nuclear Information System (INIS)

Loomis, H.H.; Wyman, R.H.

1981-01-01

An apparatus is disclosed for eliminating, in each clock distribution amplifier of a clock distribution system, sequential pulse catch-up error due to one pulse ''overtaking'' a prior clock pulse. The apparatus includes timing means to produce a periodic electromagnetic signal with a fundamental frequency having a fundamental frequency component v'01(T); an array of N signal characteristic detector means, with detector means no. 1 receiving the timing means signal and producing a change-of-state signal v1(T) in response to receipt of a signal above a predetermined threshold; N substantially identical filter means, one filter means being operatively associated with each detector means, for receiving the change-of-state signal vn(T) and producing a modified change-of-state signal v'n(T) (N 1, . . . , n) having a fundamental frequency component that is substantially proportional to v'01(T- theta n(T) with a cumulative phase shift theta n(T) having a time derivative that may be made uniformly and arbitrarily small; and with the detector means n+1 (1 < or = n< n) receiving a modified change-of-state signal vn(T) from filter means no. N and, in response to receipt of such a signal above a predetermined threshold, producing a change-of-state signal vn+1

Association between genetic variants of the clock gene and obesity and sleep duration.

Science.gov (United States)

Valladares, Macarena; Obregón, Ana María; Chaput, Jean-Philippe

2015-12-01

Obesity is a multifactorial disease caused by the interaction of genetic and environmental factors related to lifestyle aspects. It has been shown that reduced sleep is associated with increased body mass index (BMI). Circadian Locomotor Output Cycles Kaput (CLOCK) gene variants have also been associated with obesity. The objective of this mini-review was to discuss the available literature related to CLOCK gene variants associated with adiposity and sleep duration in humans. In total, 16 articles complied with the terms of the search that reported CLOCK variants associated with sleep duration, energy intake, and BMI. Overall, six CLOCK single nucleotide polymorphisms (SNPs) have been associated with sleep duration, and three variants have been associated with energy intake variables. Overall, the most studied area has been the association of CLOCK gene with obesity; close to eight common variants have been associated with obesity. The most studied CLOCK SNP in different populations is rs1801260, and most of these populations correspond to European populations. Collectively, identifying at risk CLOCK genotypes is a new area of research that may help identify individuals who are more susceptible to overeating and gaining weight when exposed to short sleep durations.

Plant circadian clocks increase photosynthesis, growth, survival, and competitive advantage.

Science.gov (United States)

Dodd, Antony N; Salathia, Neeraj; Hall, Anthony; Kévei, Eva; Tóth, Réka; Nagy, Ferenc; Hibberd, Julian M; Millar, Andrew J; Webb, Alex A R

2005-07-22

Circadian clocks are believed to confer an advantage to plants, but the nature of that advantage has been unknown. We show that a substantial photosynthetic advantage is conferred by correct matching of the circadian clock period with that of the external light-dark cycle. In wild type and in long- and short-circadian period mutants of Arabidopsis thaliana, plants with a clock period matched to the environment contain more chlorophyll, fix more carbon, grow faster, and survive better than plants with circadian periods differing from their environment. This explains why plants gain advantage from circadian control.

Data and clock transmission interface for the WCDA in LHAASO

International Nuclear Information System (INIS)

Chu, S.P.; Zhao, L.; Jiang, Z.Y.; Ma, C.; Gao, X.S.; Yang, Y.F.; Liu, S.B.; An, Q.

2016-01-01

The Water Cherenkov Detector Array (WCDA) is one of the major components of the Large High Altitude Air Shower Observatory (LHAASO). In the WCDA, 3600 Photomultiplier Tubes (PMTs) and the Front End Electronics (FEEs) are scattered over a 90000 m 2 area, while high precision time measurements (0.5 ns RMS) are required in the readout electronics. To meet this requirement, the clock has to be distributed to the FEEs with high precision. Due to the ''triggerless'' architecture, high speed data transfer is required based on the TCP/IP protocol. To simplify the readout electronics architecture and be consistent with the whole LHAASO readout electronics, the White Rabbit (WR) switches are used to transfer clock, data, and commands via a single fiber of about 400 meters. In this paper, a prototype of data and clock transmission interface for LHAASO WCDA is developed. The performance tests are conducted and the results indicate that the clock synchronization precision of the data and clock transmission is better than 50 ps. The data transmission throughput can reach 400 Mbps for one FEE board and 180 Mbps for 4 FEE boards sharing one up link port in WR switch, which is better than the requirement of the LHAASO WCDA.

Combined orbits and clocks from IGS second reprocessing

Science.gov (United States)

Griffiths, Jake

2018-05-01

The Analysis Centers (ACs) of the International GNSS Service (IGS) have reprocessed a large global network of GPS tracking data from 1994.0 until 2014.0 or later. Each AC product time series was extended uniformly till early 2015 using their weekly operational IGS contributions so that the complete combined product set covers GPS weeks 730 through 1831. Three ACs also included GLONASS data from as early as 2002 but that was insufficient to permit combined GLONASS products. The reprocessed terrestrial frame combination procedures and results have been reported already, and those were incorporated into the ITRF2014 multi-technique global frame released in 2016. This paper describes the orbit and clock submissions and their multi-AC combinations and assessments. These were released to users in early 2017 in time for the adoption of IGS14 for generating the operational IGS products. While the reprocessing goal was to enable homogeneous modeling, consistent with the current operational procedures, to be applied retrospectively to the full history of observation data in order to achieve a more suitable reference for geophysical studies, that objective has only been partially achieved. Ongoing AC analysis changes and a lack of full participation limit the consistency and precision of the finished IG2 products. Quantitative internal measures indicate that the reprocessed orbits are somewhat less precise than current operational orbits or even the later orbits from the first IGS reprocessing campaign. That is even more apparent for the clocks where a lack of robust AC participation means that it was only possible to form combined 5-min clocks but not the 30-s satellite clocks published operationally. Therefore, retrospective precise point positioning solutions by users are not recommended using the orbits and clocks. Nevertheless, the orbits do support long-term stable user solutions when used with network processing with either double differencing or explicit clock

Excitation of a magnetospheric maser through modification of the Earth’s ionosphere by high-power HF radio emission from a ground-based transmitter

International Nuclear Information System (INIS)

Markov, G. A.; Belov, A. S.; Frolov, V. L.; Rapoport, V. O.; Parrot, M.

2010-01-01

A method for controlled excitation of a magnetospheric maser through the production of artificial density ducts by high-power HF radio emission from the Earth’s surface has been proposed and implemented in an in-situ experiment. Artificial density ducts allow one to affect the maser resonator system and the excitation and propagation of low-frequency electromagnetic waves in a disturbed magnetic flux tube. The experimental data presented here were obtained at the mid-latitude Sura heating facility. The characteristics of electromagnetic and plasma disturbances at outer-ionosphere altitudes were measured using the onboard equipment of the DEMETER satellite as it passed through the magnetic flux tube rested on the region of intense generation of artificial ionospheric turbulence.

DNA Replication Is Required for Circadian Clock Function by Regulating Rhythmic Nucleosome Composition.

Science.gov (United States)

Liu, Xiao; Dang, Yunkun; Matsu-Ura, Toru; He, Yubo; He, Qun; Hong, Christian I; Liu, Yi

2017-07-20

Although the coupling between circadian and cell cycles allows circadian clocks to gate cell division and DNA replication in many organisms, circadian clocks were thought to function independently of cell cycle. Here, we show that DNA replication is required for circadian clock function in Neurospora. Genetic and pharmacological inhibition of DNA replication abolished both overt and molecular rhythmicities by repressing frequency (frq) gene transcription. DNA replication is essential for the rhythmic changes of nucleosome composition at the frq promoter. The FACT complex, known to be involved in histone disassembly/reassembly, is required for clock function and is recruited to the frq promoter in a replication-dependent manner to promote replacement of histone H2A.Z by H2A. Finally, deletion of H2A.Z uncoupled the dependence of the circadian clock on DNA replication. Together, these results establish circadian clock and cell cycle as interdependent coupled oscillators and identify DNA replication as a critical process in the circadian mechanism. Published by Elsevier Inc.

General anesthesia alters time perception by phase shifting the circadian clock.

Science.gov (United States)

Cheeseman, James F; Winnebeck, Eva C; Millar, Craig D; Kirkland, Lisa S; Sleigh, James; Goodwin, Mark; Pawley, Matt D M; Bloch, Guy; Lehmann, Konstantin; Menzel, Randolf; Warman, Guy R

2012-05-01

Following general anesthesia, people are often confused about the time of day and experience sleep disruption and fatigue. It has been hypothesized that these symptoms may be caused by general anesthesia affecting the circadian clock. The circadian clock is fundamental to our well-being because it regulates almost all aspects of our daily biochemistry, physiology, and behavior. Here, we investigated the effects of the most common general anesthetic, isoflurane, on time perception and the circadian clock using the honeybee (Apis mellifera) as a model. A 6-h daytime anesthetic systematically altered the time-compensated sun compass orientation of the bees, with a mean anticlockwise shift in vanishing bearing of 87° in the Southern Hemisphere and a clockwise shift in flight direction of 58° in the Northern Hemisphere. Using the same 6-h anesthetic treatment, time-trained bees showed a delay in the start of foraging of 3.3 h, and whole-hive locomotor-activity rhythms were delayed by an average of 4.3 h. We show that these effects are all attributable to a phase delay in the core molecular clockwork. mRNA oscillations of the central clock genes cryptochrome-m and period were delayed by 4.9 and 4.3 h, respectively. However, this effect is dependent on the time of day of administration, as is common for clock effects, and nighttime anesthesia did not shift the clock. Taken together, our results suggest that general anesthesia during the day causes a persistent and marked shift of the clock effectively inducing "jet lag" and causing impaired time perception. Managing this effect in humans is likely to help expedite postoperative recovery.

Verge and Foliot Clock Escapement: A Simple Dynamical System

Science.gov (United States)

Denny, Mark

2010-01-01

The earliest mechanical clocks appeared in Europe in the 13th century. From about 1250 CE to 1670 CE, these simple clocks consisted of a weight suspended from a rope or chain that was wrapped around a horizontal axle. To tell time, the weight must fall with a slow uniform speed, but, under the action of gravity alone, such a suspended weight would…

Development and entrainment of the colonic circadian clock during ontogenesis

Czech Academy of Sciences Publication Activity Database

Polidarová, Lenka; Olejníková, Lucie; Paušlyová, Lucia; Sládek, Martin; Soták, Matúš; Pácha, Jiří; Sumová, Alena

2014-01-01

Roč. 306, č. 4 (2014), G346-G356 ISSN 0193-1857 R&D Projects: GA ČR(CZ) GAP303/12/1108 Institutional support: RVO:67985823 Keywords : circadian clock * clock gene * ontogenesis * circadian entrainment Subject RIV: ED - Physiology Impact factor: 3.798, year: 2014

Interdependence of nutrient metabolism and the circadian clock system: Importance for metabolic health

Science.gov (United States)

Ribas-Latre, Aleix; Eckel-Mahan, Kristin

2016-01-01

Background While additional research is needed, a number of large epidemiological studies show an association between circadian disruption and metabolic disorders. Specifically, obesity, insulin resistance, cardiovascular disease, and other signs of metabolic syndrome all have been linked to circadian disruption in humans. Studies in other species support this association and generally reveal that feeding that is not in phase with the external light/dark cycle, as often occurs with night or rotating shift workers, is disadvantageous in terms of energy balance. As food is a strong driver of circadian rhythms in the periphery, understanding how nutrient metabolism drives clocks across the body is important for dissecting out why circadian misalignment may produce such metabolic effects. A number of circadian clock proteins as well as their accessory proteins (such as nuclear receptors) are highly sensitive to nutrient metabolism. Macronutrients and micronutrients can function as zeitgebers for the clock in a tissue-specific way and can thus impair synchrony between clocks across the body, or potentially restore synchrony in the case of circadian misalignment. Circadian nuclear receptors are particularly sensitive to nutrient metabolism and can alter tissue-specific rhythms in response to changes in the diet. Finally, SNPs in human clock genes appear to be correlated with diet-specific responses and along with chronotype eventually may provide valuable information from a clinical perspective on how to use diet and nutrition to treat metabolic disorders. Scope of review This article presents a background of the circadian clock components and their interrelated metabolic and transcriptional feedback loops, followed by a review of some recent studies in humans and rodents that address the effects of nutrient metabolism on the circadian clock and vice versa. We focus on studies in which results suggest that nutrients provide an opportunity to restore or, alternatively

The rhythm of feeding : Effect of nutrients on metabolism and the molecular clock

NARCIS (Netherlands)

Oosterman, J.E.

2017-01-01

This thesis describes studies we performed to assess the relationship between nutrients and the circadian clock. We assessed the effects of sugar and fatty acids on the daily rhythmicity of hepatic clock genes and whole-body metabolism in vivo, and on circadian rhythmicity of clock genes in vitro.

PHARAO space atomic clock: new developments on the laser source

Science.gov (United States)

Saccoccio, Muriel; Loesel, Jacques; Coatantiec, Claude; Simon, Eric; Laurent, Philippe; Lemonde, Pierre; Maksimovic, I.; Abgrall, M.

2017-11-01

The PHARAO project purpose is to open the way for a new atomic clock generation in space, where laser cooling techniques and microgravity allow high frequency stability and accuracy. The French space agency, CNES is funding and managing the clock construction. The French SYRTE and LKB laboratories are scientific and technical advisers for the clock requirements and the follow-up of subsystem development in industrial companies. EADS SODERN is developing two main subsystems of the PHARAO clock: the Laser Source and the Cesium Tube where atoms are cooled, launched, selected and detected by laser beams. The Laser Source includes an optical bench and electronic devices to generate the laser beams required. This paper describes PHARAO and the role laser beams play in its principle of operation. Then we present the Laser Source design, the technologies involved, and the status of development. Lastly, we focus of a key equipment to reach the performances expected, which is the Extended Cavity Laser Diode.

Practical security analysis of continuous-variable quantum key distribution with jitter in clock synchronization

Science.gov (United States)

Xie, Cailang; Guo, Ying; Liao, Qin; Zhao, Wei; Huang, Duan; Zhang, Ling; Zeng, Guihua

2018-03-01

How to narrow the gap of security between theory and practice has been a notoriously urgent problem in quantum cryptography. Here, we analyze and provide experimental evidence of the clock jitter effect on the practical continuous-variable quantum key distribution (CV-QKD) system. The clock jitter is a random noise which exists permanently in the clock synchronization in the practical CV-QKD system, it may compromise the system security because of its impact on data sampling and parameters estimation. In particular, the practical security of CV-QKD with different clock jitter against collective attack is analyzed theoretically based on different repetition frequencies, the numerical simulations indicate that the clock jitter has more impact on a high-speed scenario. Furthermore, a simplified experiment is designed to investigate the influence of the clock jitter.

Glucocorticoids affect 24 h clock genes expression in human adipose tissue explant cultures.

Directory of Open Access Journals (Sweden)

Purificación Gómez-Abellán

Full Text Available to examine firstly whether CLOCK exhibits a circadian expression in human visceral (V and subcutaneous (S adipose tissue (AT in vitro as compared with BMAL1 and PER2, and secondly to investigate the possible effect of the glucocorticoid analogue dexamethasone (DEX on positive and negative clock genes expression.VAT and SAT biopsies were obtained from morbid obese women (body mass index ≥ 40 kg/m(2 (n = 6. In order to investigate rhythmic expression pattern of clock genes and the effect of DEX on CLOCK, PER2 and BMAL1 expression, control AT (without DEX and AT explants treated with DEX (2 hours were cultured during 24 h and gene expression was analyzed at the following times: 10:00 h, 14:00 h, 18:00 h, 22:00 h, 02:00 h and 06:00 h, using qRT-PCR.CLOCK, BMAL1 and PER2 expression exhibited circadian patterns in both VAT and SAT explants that were adjusted to a typical 24 h sinusoidal curve. PER2 expression (negative element was in antiphase with respect to CLOCK and in phase with BMAL1 expression (both positive elements in the SAT (situation not present in VAT. A marked effect of DEX exposure on both positive and negative clock genes expression patterns was observed. Indeed, DEX treatment modified the rhythmicity pattern towards altered patterns with a period lower than 24 hours in all genes and in both tissues.24 h patterns in CLOCK and BMAL1 (positive clock elements and PER2 (negative element mRNA levels were observed in human adipose explants. These patterns were altered by dexamethasone exposure.

Clock ambiguity and the emergence of physical laws

International Nuclear Information System (INIS)

Albrecht, Andreas; Iglesias, Alberto

2008-01-01

The process of identifying a time variable in time-reparameterization invariant theories results in great ambiguities about the actual laws of physics described by a given theory. A theory set up to describe one set of physical laws can equally well be interpreted as describing any other laws of physics by making a different choice of time variable or clock. In this article we demonstrate how this 'clock ambiguity' arises and then discuss how one might still hope to extract specific predictions about the laws of physics even when the clock ambiguity is present. We argue that a requirement of quasiseparability should play a critical role in such an analysis. As a step in this direction, we compare the Hamiltonian of a local quantum field theory with a completely random Hamiltonian. We find that any random Hamiltonian (constructed in a sufficiently large space) can yield a 'good enough' approximation to a local field theory. Based on this result we argue that theories that suffer from the clock ambiguity may in the end provide a viable fundamental framework for physics in which locality can be seen as a strongly favored (or predicted) emergent behavior. We also speculate on how other key aspects of known physics such as gauge symmetries and Poincare invariance might be predicted to emerge in this framework.

An experiment designed to verify the general theory of relativity; Une experience destinee a verifier la theorie de la relativite generalisee

Energy Technology Data Exchange (ETDEWEB)

Surdin, Maurice [Commissariat a l' energie atomique et aux energies alternatives - CEA (France)

1960-07-01

The project for an experiment which uses the effect of gravitation on Maser-type clocks placed on the ground at two different heights and which is designed to verify the general theory of relativity. Reprint of a paper published in Comptes rendus des seances de l'Academie des Sciences, t. 250, p. 299-301, sitting of 11 January 1960 [French] Projet d'une experience, utilisant l'effet de gravitation sur des horloges du type Maser placees sur la terre a deux altitudes differentes, et destinee a verifier la theorie de la relativite generalisee. Reproduction d'un article publie dans les Comptes rendus des seances de l'Academie des Sciences, t. 250, p. 299-301, seance du 11 janvier 1960.

Molecular clock on a neutral network.

Science.gov (United States)

Raval, Alpan

2007-09-28

The number of fixed mutations accumulated in an evolving population often displays a variance that is significantly larger than the mean (the overdispersed molecular clock). By examining a generic evolutionary process on a neutral network of high-fitness genotypes, we establish a formalism for computing all cumulants of the full probability distribution of accumulated mutations in terms of graph properties of the neutral network, and use the formalism to prove overdispersion of the molecular clock. We further show that significant overdispersion arises naturally in evolution when the neutral network is highly sparse, exhibits large global fluctuations in neutrality, and small local fluctuations in neutrality. The results are also relevant for elucidating aspects of neutral network topology from empirical measurements of the substitution process.

Alternative splicing and nonsense-mediated decay of circadian clock genes under environmental stress conditions in Arabidopsis.

Science.gov (United States)

Kwon, Young-Ju; Park, Mi-Jeong; Kim, Sang-Gyu; Baldwin, Ian T; Park, Chung-Mo

2014-05-19

The circadian clock enables living organisms to anticipate recurring daily and seasonal fluctuations in their growth habitats and synchronize their biology to the environmental cycle. The plant circadian clock consists of multiple transcription-translation feedback loops that are entrained by environmental signals, such as light and temperature. In recent years, alternative splicing emerges as an important molecular mechanism that modulates the clock function in plants. Several clock genes are known to undergo alternative splicing in response to changes in environmental conditions, suggesting that the clock function is intimately associated with environmental responses via the alternative splicing of the clock genes. However, the alternative splicing events of the clock genes have not been studied at the molecular level. We systematically examined whether major clock genes undergo alternative splicing under various environmental conditions in Arabidopsis. We also investigated the fates of the RNA splice variants of the clock genes. It was found that the clock genes, including EARLY FLOWERING 3 (ELF3) and ZEITLUPE (ZTL) that have not been studied in terms of alternative splicing, undergo extensive alternative splicing through diverse modes of splicing events, such as intron retention, exon skipping, and selection of alternative 5' splice site. Their alternative splicing patterns were differentially influenced by changes in photoperiod, temperature extremes, and salt stress. Notably, the RNA splice variants of TIMING OF CAB EXPRESSION 1 (TOC1) and ELF3 were degraded through the nonsense-mediated decay (NMD) pathway, whereas those of other clock genes were insensitive to NMD. Taken together, our observations demonstrate that the major clock genes examined undergo extensive alternative splicing under various environmental conditions, suggesting that alternative splicing is a molecular scheme that underlies the linkage between the clock and environmental stress

Alternative splicing and nonsense-mediated decay of circadian clock genes under environmental stress conditions in Arabidopsis

Science.gov (United States)

2014-01-01

Background The circadian clock enables living organisms to anticipate recurring daily and seasonal fluctuations in their growth habitats and synchronize their biology to the environmental cycle. The plant circadian clock consists of multiple transcription-translation feedback loops that are entrained by environmental signals, such as light and temperature. In recent years, alternative splicing emerges as an important molecular mechanism that modulates the clock function in plants. Several clock genes are known to undergo alternative splicing in response to changes in environmental conditions, suggesting that the clock function is intimately associated with environmental responses via the alternative splicing of the clock genes. However, the alternative splicing events of the clock genes have not been studied at the molecular level. Results We systematically examined whether major clock genes undergo alternative splicing under various environmental conditions in Arabidopsis. We also investigated the fates of the RNA splice variants of the clock genes. It was found that the clock genes, including EARLY FLOWERING 3 (ELF3) and ZEITLUPE (ZTL) that have not been studied in terms of alternative splicing, undergo extensive alternative splicing through diverse modes of splicing events, such as intron retention, exon skipping, and selection of alternative 5′ splice site. Their alternative splicing patterns were differentially influenced by changes in photoperiod, temperature extremes, and salt stress. Notably, the RNA splice variants of TIMING OF CAB EXPRESSION 1 (TOC1) and ELF3 were degraded through the nonsense-mediated decay (NMD) pathway, whereas those of other clock genes were insensitive to NMD. Conclusion Taken together, our observations demonstrate that the major clock genes examined undergo extensive alternative splicing under various environmental conditions, suggesting that alternative splicing is a molecular scheme that underlies the linkage between the clock

Detecting a Multi-Homed Device Using Clock Skew

Science.gov (United States)

2016-09-01

15]. The TCP timestamp value is determined by a virtual “timestamp clock” that is based on the frequency of operation of the device’s system clock...received [16]. Figure 8. TCP Timestamp Options Field. Source: [16]. The value of the timestamp comes from a virtual internal clock that is known as...Testing 18 One of the Raspberry Pis had an added USB 2.0 Gigabit LAN adapter that was used as its second connection to the network. The connections for

Discrete gene replication events drive coupling between the cell cycle and circadian clocks.

Science.gov (United States)

Paijmans, Joris; Bosman, Mark; Ten Wolde, Pieter Rein; Lubensky, David K

2016-04-12

Many organisms possess both a cell cycle to control DNA replication and a circadian clock to anticipate changes between day and night. In some cases, these two rhythmic systems are known to be coupled by specific, cross-regulatory interactions. Here, we use mathematical modeling to show that, additionally, the cell cycle generically influences circadian clocks in a nonspecific fashion: The regular, discrete jumps in gene-copy number arising from DNA replication during the cell cycle cause a periodic driving of the circadian clock, which can dramatically alter its behavior and impair its function. A clock built on negative transcriptional feedback either phase-locks to the cell cycle, so that the clock period tracks the cell division time, or exhibits erratic behavior. We argue that the cyanobacterium Synechococcus elongatus has evolved two features that protect its clock from such disturbances, both of which are needed to fully insulate it from the cell cycle and give it its observed robustness: a phosphorylation-based protein modification oscillator, together with its accompanying push-pull read-out circuit that responds primarily to the ratios of different phosphoform concentrations, makes the clock less susceptible to perturbations in protein synthesis; the presence of multiple, asynchronously replicating copies of the same chromosome diminishes the effect of replicating any single copy of a gene.

Discovery of pulsed OH maser emission stimulated by a pulsar.

Science.gov (United States)

Weisberg, Joel M; Johnston, Simon; Koribalski, Bärbel; Stanimirovic, Snezana

2005-07-01

Stimulated emission of radiation has not been directly observed in astrophysical situations up to this time. Here we demonstrate that photons from pulsar B1641-45 stimulate pulses of excess 1720-megahertz line emission in an interstellar hydroxyl (OH) cloud. As this stimulated emission is driven by the pulsar, it varies on a few-millisecond time scale, which is orders of magnitude shorter than the quickest OH maser variations previously detected. Our 1612-megahertz spectra are inverted copies of the 1720-megahertz spectra. This "conjugate line" phenomenon enables us to constrain the properties of the interstellar OH line-producing gas. We also show that pulsar signals undergo significantly deeper OH absorption than do other background sources, which confirms earlier tentative findings that OH clouds are clumpier on small scales than are neutral hydrogen clouds.

High-power, high-frequency, annular-beam free-electron maser

International Nuclear Information System (INIS)

Fazio, M.V.; Carlsten, B.E.; Earley, L.M.; Fortgang, C.M.; Haynes, W.B.; Haddock, P.C.

1998-01-01

The authors have developed a 15--17 GHz free electron maser (FEM) capable of producing high power pulses with a phase stability appropriate for linear collider applications. The electron beam source is a 1 micros, 800 kV, 5 kA, 6-cm-dia annular electron beam machine called BANSHEE. The beam interacts with the TM 02 mode Raman FEM amplifier in a corrugated cylindrical waveguide where the beam runs close to the interaction device walls to reduce the power density in the fields. They studied the phase stability by analyzing the dispersion relation for an axial FEL, in which the rf field was transversely wiggled and the electron trajectories were purely longitudinal. Detailed particle-in-cell simulations demonstrated the transverse wiggling of the rf mode and the axial FEL interaction and explicit calculations of the growing root of the dispersion relation are included to verify the phase stability

Oscillating perceptions: the ups and downs of the CLOCK protein in ...

Indian Academy of Sciences (India)

2008-12-31

Dec 31, 2008 ... A functional mouse CLOCK protein has long been thought to be essential for mammalian circadian ... ordinated actions of the Ror families of transcriptional acti- ..... CLOCK-deficient mice expressing the mPER2::LUC fusion.

Performance Evaluation of Clock Recovery for Coherent Mode Division Multiplexed Systems

DEFF Research Database (Denmark)

Medeiros Diniz, Júlio César; Piels, Molly; Zibar, Darko

2017-01-01

The impact of mode mixing and group delay spread on clock tone quality of a 6-mode 32 GBd NRZ-QPSK MDM system is investigated. Even for low group delay spread, strong coupling causes clock tone disappearance....

Regulation of behavioral circadian rhythms and clock protein PER1 by the deubiquitinating enzyme USP2

DEFF Research Database (Denmark)

Yang, Yaoming; Duguay, David; Bédard, Nathalie

2012-01-01

Endogenous 24-hour rhythms are generated by circadian clocks located in most tissues. The molecular clock mechanism is based on feedback loops involving clock genes and their protein products. Post-translational modifications, including ubiquitination, are important for regulating the clock...

Does the combination of the MMSE and clock drawing test (mini-clock) improve the detection of mild Alzheimer's disease and mild cognitive impairment?

Science.gov (United States)

Cacho, Jesús; Benito-León, Julián; García-García, Ricardo; Fernández-Calvo, Bernardino; Vicente-Villardón, José Luis; Mitchell, Alex J

2010-01-01

There is currently a need to develop tools to identify patients with mild AD and mild cognitive impairment (MCI). We determined the validity and reliability of a brief, easily administered cognitive screening battery consisting of fusion of two well-known brief tests (Mini-Mental Status Examination [MMSE] and Clock Drawing Test [CDT]) (Mini-clock) to differentiate between patients with mild AD, MCI, and healthy control subjects. 66 consecutive patients with mild AD, 21 with MCI, and 66 healthy controls seen in a memory clinic setting were compared. Receiver operating characteristic (ROC) curve analysis was used to calculate the cut-off value permitting discrimination between mild AD, MCI, and healthy control subjects. Interrater and test-retest reliability were also assessed. Mean cognitive scores for patients with AD, MCI, and control subjects on all two individual tests were significantly different (for each, p Mini-clock was higher than that obtained with MMSE or CDT in differentiating mild AD from controls (0.973 vs. 0.952 and 0.881, respectively) and MCI from controls (0.855 vs. 0.821 and 0.779, respectively). Test-retest reliability for the Mini-clock was 0.99, meanwhile interrater reliability was 0.87. The mean time to complete the test for all subjects was 8 min and 50 s. The Mini-clock is highly sensitive and specific in the detection of mild AD and reasonably accurate when attempting to separate MCI from health controls. It has a high interrater and test-retest reliability, can be quickly administered, and does not require major training.

Rapid resetting of human peripheral clocks by phototherapy during simulated night shift work.

Science.gov (United States)

Cuesta, Marc; Boudreau, Philippe; Cermakian, Nicolas; Boivin, Diane B

2017-11-24

A majority of night shift workers have their circadian rhythms misaligned to their atypical schedule. While bright light exposure at night is known to reset the human central circadian clock, the behavior of peripheral clocks under conditions of shift work is more elusive. The aim of the present study was to quantify the resetting effects of bright light exposure on both central (plasma cortisol and melatonin) and peripheral clocks markers (clock gene expression in peripheral blood mononuclear cells, PBMCs) in subjects living at night. Eighteen healthy subjects were enrolled to either a control (dim light) or a bright light group. Blood was sampled at baseline and on the 4 th day of simulated night shift. In response to a night-oriented schedule, the phase of PER1 and BMAL1 rhythms in PBMCs was delayed by ~2.5-3 h (P shift was observed for the other clock genes and the central markers. Three cycles of 8-h bright light induced significant phase delays (P night-oriented schedule and a rapid resetting effect of nocturnal bright light exposure on peripheral clocks.

A Pseudo Fractional-N Clock Generator with 50% Duty Cycle Output

Science.gov (United States)

Yang, Wei-Bin; Lo, Yu-Lung; Chao, Ting-Sheng

A proposed pseudo fractional-N clock generator with 50% duty cycle output is presented by using the pseudo fractional-N controller for SoC chips and the dynamic frequency scaling applications. The different clock frequencies can be generated with the particular phase combinations of a four-stage voltage-controlled oscillator (VCO). It has been fabricated in a 0.13µm CMOS technology, and work with a supply voltage of 1.2V. According to measured results, the frequency range of the proposed pseudo fractional-N clock generator is from 71.4MHz to 1GHz and the peak-to-peak jitter is less than 5% of the output period. Duty cycle error rates of the output clock frequencies are from 0.8% to 2% and the measured power dissipation of the pseudo fractional-N controller is 146µW at 304MHz.

Technology development for laser-cooled clocks on the International Space Station

Science.gov (United States)

Klipstein, W. M.

2003-01-01

The PARCS experiment will use a laser-cooled cesium atomic clock operating in the microgravity environment aboard the International Space Station to provide both advanced tests of gravitational theory to demonstrate a new cold-atom clock technology for space.

User-Defined Clocks in the Real-Time Specification for Java

DEFF Research Database (Denmark)

Wellings, Andy; Schoeberl, Martin

2011-01-01

This paper analyses the new user-defined clock model that is to be supported in Version 1.1 of the Real-Time Specification for Java (RTSJ). The model is a compromise between the current position, where there is no support for user-defined clocks, and a fully integrated model. The paper investigat...

Observation of Poincaré-Andronov-Hopf Bifurcation in Cyclotron Maser Emission from a Magnetic Plasma Trap

Science.gov (United States)

Shalashov, A. G.; Gospodchikov, E. D.; Izotov, I. V.; Mansfeld, D. A.; Skalyga, V. A.; Tarvainen, O.

2018-04-01

We report the first experimental evidence of a controlled transition from the generation of periodic bursts of electromagnetic radiation into the continuous-wave regime of a cyclotron maser formed in magnetically confined nonequilibrium plasma. The kinetic cyclotron instability of the extraordinary wave of weakly inhomogeneous magnetized plasma is driven by the anisotropic electron population resulting from electron cyclotron plasma heating in a MHD-stable minimum-B open magnetic trap.

Reference clock parameters for digital communications systems applications

Science.gov (United States)

Kartaschoff, P.

1981-01-01

The basic parameters relevant to the design of network timing systems describe the random and systematic time departures of the system elements, i.e., master (or reference) clocks, transmission links, and other clocks controlled over the links. The quantitative relations between these parameters were established and illustrated by means of numerical examples based on available measured data. The examples were limited to a simple PLL control system but the analysis can eventually be applied to more sophisticated systems at the cost of increased computational effort.

An experiment designed to verify the general theory of relativity

International Nuclear Information System (INIS)

Surdin, Maurice

1960-01-01

The project for an experiment which uses the effect of gravitation on Maser-type clocks placed on the ground at two different heights and which is designed to verify the general theory of relativity. Reprint of a paper published in Comptes rendus des seances de l'Academie des Sciences, t. 250, p. 299-301, sitting of 11 January 1960 [fr

Norman Ramsey. Nobel Prize Winner in Physics (1989)

International Nuclear Information System (INIS)

2003-01-01

Norman Ramsey (Washington 1915) received the Nobel Prize in Physics (shared with con H. G. Dehmelt and W. Paul) for the development of study techniques for Atomic Physics. This tireless researcher participated in the discovery of the Magnetic Resonance Method for Molecular Emission. He invented the hydrogen maser and the hydrogen atomic clock, in addition to being a profile author. (Author)

Norman Ramsey. Nobel Prize Winner in Physics (1989); Norman Ramsey. Premio Nobel de fisica (1989)

Energy Technology Data Exchange (ETDEWEB)

NONE

2003-07-01

Norman Ramsey (Washington 1915) received the Nobel Prize in Physics (shared with con H. G. Dehmelt and W. Paul) for the development of study techniques for Atomic Physics. This tireless researcher participated in the discovery of the Magnetic Resonance Method for Molecular Emission. He invented the hydrogen maser and the hydrogen atomic clock, in addition to being a profile author. (Author)

The Fermilab D0 Master Clock System

International Nuclear Information System (INIS)

Rotolo, C.; Fachin, M.; Chappa, S.; Rauch, M.; Needles, C.; Dyer, A.

1991-11-01

The Clock System provides bunch crossing related timing signals to various detector subsystems. Accelerator synchronization and monitoring as well as timing signal generation and distribution are discussed. The system is built using three module types implemented in Eurostandard hardware with a VME communications interface. The first two types of modules are used to facilitate synchronization with the accelerator and to generate 23 timing signals that are programmable with one RF bucket (18.8 ns) resolution and 1 ns accuracy. Fifty-four of the third module type are used to distribute the timing signals and two synchronous 53 MHz and 106 MHz clocks to various detector subsystems. 6 refs., 5 figs

Expression of core clock genes in colorectal tumour cells compared with normal mucosa

DEFF Research Database (Denmark)

Fonnes, S; Donatsky, A M; Gögenur, I

2015-01-01

AIM: Experimental studies have shown that some circadian core clock genes may act as tumour suppressors and have an important role in the response to oncological treatment. This study investigated the evidence regarding modified expression of core clock genes in colorectal cancer and its...... expression of colorectal cancer cells compared with healthy mucosa cells from specimens analysed by real-time or quantitative real-time polymer chain reaction. The expression of the core clock genes Period, Cryptochrome, Bmal1 and Clock in colorectal tumours were compared with healthy mucosa and correlated...... with clinicopathological features and survival. RESULTS: Seventy-four articles were identified and 11 studies were included. Overall, gene expression of Period was significantly decreased in colorectal cancer cells compared with healthy mucosa cells. This tendency was also seen in the gene expression of Clock. Other core...

Method and apparatus to debug an integrated circuit chip via synchronous clock stop and scan

Science.gov (United States)

Bellofatto, Ralph E [Ridgefield, CT; Ellavsky, Matthew R [Rochester, MN; Gara, Alan G [Mount Kisco, NY; Giampapa, Mark E [Irvington, NY; Gooding, Thomas M [Rochester, MN; Haring, Rudolf A [Cortlandt Manor, NY; Hehenberger, Lance G [Leander, TX; Ohmacht, Martin [Yorktown Heights, NY

2012-03-20

An apparatus and method for evaluating a state of an electronic or integrated circuit (IC), each IC including one or more processor elements for controlling operations of IC sub-units, and each the IC supporting multiple frequency clock domains. The method comprises: generating a synchronized set of enable signals in correspondence with one or more IC sub-units for starting operation of one or more IC sub-units according to a determined timing configuration; counting, in response to one signal of the synchronized set of enable signals, a number of main processor IC clock cycles; and, upon attaining a desired clock cycle number, generating a stop signal for each unique frequency clock domain to synchronously stop a functional clock for each respective frequency clock domain; and, upon synchronously stopping all on-chip functional clocks on all frequency clock domains in a deterministic fashion, scanning out data values at a desired IC chip state. The apparatus and methodology enables construction of a cycle-by-cycle view of any part of the state of a running IC chip, using a combination of on-chip circuitry and software.

Direct regulation of myocardial triglyceride metabolism by the cardiomyocyte circadian clock

Science.gov (United States)

Maintenance of circadian alignment between an organism and its environment is essential to ensure metabolic homeostasis. Synchrony is achieved by cell autonomous circadian clocks. Despite a growing appreciation of the integral relation between clocks and metabolism, little is known regarding the dir...

State-of-the-art of high power gyro-devices and free electron masers 1994

International Nuclear Information System (INIS)

Thumm, M.

1995-04-01

At present, gyrotron oscillators are mainly used as high power millimeter wave sources for electron cyclotron resonance heating (ECRH) and diagnostics of magnetically confined plasmas for generation of energy by controlled thermonuclear fusion. 140 GHz gyrotrons with output power P out =0.54 MW, pulse length τ=3.0 s and efficiency η=42% are commercially available. Total efficiencies around 50% have been achieved using single-stage depressed collectors. Diagnostic gyrotrons deliver P out =40 kW with τ=40 μs at frequencies up to 650 GHz (η≥4%). Recently, gyrotron oscillators have also been successfully used in material processing and plasma chemistry. Such technological applications require gyrotrons with the following parameters: f≥24 GHz, P out =10-50 kW, CW, η≥30%. This paper reports on achievements and problems related to the development of very high power mm-wave gyrotrons for long pulse or CW operation and describes the microwave technological pecularities of the different development steps. In addition, this work gives a short overview of the present development of gyrotrons for technological applications, relativistic gyrotrons, quasi-optical gyrotrons, cyclotron autoresonance masers (CARMs), gyro klystrons, gyro-TWT amplifiers, gyrotwystron amplifiers, gyro-BWO's, peniotrons and free electron masers (FEMs). The most impressive FEM output parameters are: P out =2 GW, τ=20 ns, η=13% at 140 GHz (LLNL) and P out =15 kW, τ=20 μs, η=5% in the range from 120 to 900 GHz (UCSB). (orig.) [de

Noise in state of the art clocks and their impact for fundamental physics

Science.gov (United States)

Maleki, L.

2001-01-01

In this paper a review of the use of advanced atomic clocks in testing the fundamental physical laws will be presented. Noise sources of clocks will be discussed, together with an outline their characterization based on current models. The paper will conclude with a discussion of recent attempts to reduce the fundamental, as well as technical noise in atomic clocks.

How do you manage early or late clock-ins? .

Science.gov (United States)

Marlowe, Cathy L

2013-08-01

My current practice has historically been very strict with hourly employees. The workday is 8:30 a.m. to 5 p.m. for most employees. They are to clock in and out at exactly those times unless overtime has been approved. (Staff working with late patients are exempt.) My business manager is constantly fighting over clock-ins 15 to 20 minutes early or late, with similar clock-outs. Staff may have a stop to make and would like to make up those 15 minutes. We do grant paid time off in an initial minimum block of 30 minutes to assist with some of this. ... The issue is not overtime, as we're well aware that we have to pay for it when appropriate. It's simply to streamline our policy and make it fair. ... I'm looking for practice policies that deal with employee variances from the 8 a.m. to 4:30 p.m. clock-ins. For example, someone wants to come in 30 minutes early in order to leave 30 minutes early for an appointment. Or someone comes in 22 minutes late due to traffic and wants either to make it up or to take the minimal half-hour paid-time-off time.

Factors reducing the expected deflection in initial orientation in clock-shifted homing pigeons.

Science.gov (United States)

Gagliardo, Anna; Odetti, Francesca; Ioalè, Paolo

2005-02-01

To orient from familiar sites, homing pigeons can rely on both an olfactory map and visual familiar landmarks. The latter can in principle be used in two different ways: either within a topographical map exploited for piloting or in a so-called mosaic map associated with a compass bearing. One way to investigate the matter is to put the compass and the topographical information in conflict by releasing clock-shifted pigeons from familiar locations. Although the compass orientation is in general dominant over a piloting strategy, a stronger or weaker tendency to correct towards the home direction by clock-shifted pigeons released from very familiar sites has often been observed. To investigate which factors are involved in the reduction of the deviation due to clock-shift, we performed a series of releases with intact and anosmic pigeons from familiar sites in unshifted and clock-shifted conditions and a series of releases from the same sites with naive clock-shifted birds. Our data suggest that the following factors have a role in reducing deviation due to the clock-shift: familiarity with the release site, the lack of olfactory information and some unknown site-dependent features.

Frequency comparison of lattice clocks toward the redefinition of the second

International Nuclear Information System (INIS)

Ido, T

2014-01-01

Strontium is the most popular species for optical lattice clocks. Recent reports of the accuracies from Boulder, U.S. and Tokyo reach 10 −18 level, which is better than state-of-the-art caesium clocks more than one order of magnitude. While this achievement accelerates the discussion to redefine the second, the agreement of frequencies in separate laboratories is of critical importance. For this context, intercontinental comparison of Sr lattice clocks were demonstrated between Japan and Germany using a satellite-based technique. The frequency difference was consistent with zero with an uncertainty of 1.6 × 10 −15

Phase noise analysis of clock recovery based on an optoelectronic phase-locked loop

DEFF Research Database (Denmark)

Zibar, Darko; Mørk, Jesper; Oxenløwe, Leif Katsuo

2007-01-01

A detailed theoretical analysis of a clock-recovery (CR) scheme based on an optoelectronic phase-locked loop is presented. The analysis emphasizes the phase noise performance, taking into account the noise of the input data signal, the local voltage-controlled oscillator (VCO), and the laser....... It is shown that a large loop length results in a higher timing jitter of the recovered clock signal. The impact of the loop length on the clock signal jitter can be reduced by using a low-noise VCO and a low loop filter bandwidth. Using the model, the timing jitter of the recovered optical and electrical...... clock signal can be evaluated. We numerically investigate the timing jitter requirements for combined electrical/optical local oscillators, in order for the recovered clock signal to have less jitter than that of the input signal. The timing jitter requirements for the free-running laser and the VCO...

Timing Jitter Analysis for Clock recovery Circuits Based on an Optoelectronic Phase-Locked Loop (OPLL)

DEFF Research Database (Denmark)

Zibar, Darko; Mørk, Jesper; Oxenløwe, Leif Katsuo

2005-01-01

Timing jitter of an OPLL based clock recovery is investigated. We demonstrate how loop gain, input and VCO signal jitter, loop filter bandwidth and a loop time delay influence jitter of the extracted clock signal......Timing jitter of an OPLL based clock recovery is investigated. We demonstrate how loop gain, input and VCO signal jitter, loop filter bandwidth and a loop time delay influence jitter of the extracted clock signal...

An association between clock genes and clock-controlled cell cycle genes in murine colorectal tumors

Czech Academy of Sciences Publication Activity Database

Soták, Matúš; Polidarová, Lenka; Ergang, Peter; Sumová, Alena; Pácha, Jiří

2013-01-01

Roč. 132, č. 5 (2013), s. 1032-1041 ISSN 0020-7136 R&D Projects: GA MZd(CZ) NS9982 Institutional research plan: CEZ:AV0Z50110509 Keywords : cancer * circadian rhythm * peripheral circadian clock Subject RIV: FE - Other Internal Medicine Disciplines Impact factor: 5.007, year: 2013

The expression of melanopsin and clock genes in Xenopus laevis melanophores and their modulation by melatonin

Energy Technology Data Exchange (ETDEWEB)

Bluhm, A.P.C.; Obeid, N.N.; Castrucci, A.M.L.; Visconti, M.A. [Departamento de Fisiologia, Instituto de Biociências, Universidade de São Paulo, São Paulo, SP (Brazil)

2012-05-25

Vertebrates have a central clock and also several peripheral clocks. Light responses might result from the integration of light signals by these clocks. The dermal melanophores of Xenopus laevis have a photoreceptor molecule denominated melanopsin (OPN4x). The mechanisms of the circadian clock involve positive and negative feedback. We hypothesize that these dermal melanophores also present peripheral clock characteristics. Using quantitative PCR, we analyzed the pattern of temporal expression of Opn4x and the clock genes Per1, Per2, Bmal1, and Clock in these cells subjected to a 14-h light:10-h dark (14L:10D) regime or constant darkness (DD). Also, in view of the physiological role of melatonin in the dermal melanophores of X. laevis, we determined whether melatonin modulates the expression of these clock genes. These genes show a time-dependent expression pattern when these cells are exposed to 14L:10D, which differs from the pattern observed under DD. Cells kept in DD for 5 days exhibited overall increased mRNA expression for Opn4x and Clock, and a lower expression for Per1, Per2, and Bmal1. When the cells were kept in DD for 5 days and treated with melatonin for 1 h, 24 h before extraction, the mRNA levels tended to decrease for Opn4x and Clock, did not change for Bmal1, and increased for Per1 and Per2 at different Zeitgeber times (ZT). Although these data are limited to one-day data collection, and therefore preliminary, we suggest that the dermal melanophores of X. laevis might have some characteristics of a peripheral clock, and that melatonin modulates, to a certain extent, melanopsin and clock gene expression.

The expression of melanopsin and clock genes in Xenopus laevis melanophores and their modulation by melatonin

International Nuclear Information System (INIS)

Bluhm, A.P.C.; Obeid, N.N.; Castrucci, A.M.L.; Visconti, M.A.

2012-01-01

Vertebrates have a central clock and also several peripheral clocks. Light responses might result from the integration of light signals by these clocks. The dermal melanophores of Xenopus laevis have a photoreceptor molecule denominated melanopsin (OPN4x). The mechanisms of the circadian clock involve positive and negative feedback. We hypothesize that these dermal melanophores also present peripheral clock characteristics. Using quantitative PCR, we analyzed the pattern of temporal expression of Opn4x and the clock genes Per1, Per2, Bmal1, and Clock in these cells subjected to a 14-h light:10-h dark (14L:10D) regime or constant darkness (DD). Also, in view of the physiological role of melatonin in the dermal melanophores of X. laevis, we determined whether melatonin modulates the expression of these clock genes. These genes show a time-dependent expression pattern when these cells are exposed to 14L:10D, which differs from the pattern observed under DD. Cells kept in DD for 5 days exhibited overall increased mRNA expression for Opn4x and Clock, and a lower expression for Per1, Per2, and Bmal1. When the cells were kept in DD for 5 days and treated with melatonin for 1 h, 24 h before extraction, the mRNA levels tended to decrease for Opn4x and Clock, did not change for Bmal1, and increased for Per1 and Per2 at different Zeitgeber times (ZT). Although these data are limited to one-day data collection, and therefore preliminary, we suggest that the dermal melanophores of X. laevis might have some characteristics of a peripheral clock, and that melatonin modulates, to a certain extent, melanopsin and clock gene expression

Bayesian view of single-qubit clocks, and an energy versus accuracy tradeoff

Science.gov (United States)

Gopalkrishnan, Manoj; Kandula, Varshith; Sriram, Praveen; Deshpande, Abhishek; Muralidharan, Bhaskaran

2017-09-01

We bring a Bayesian approach to the analysis of clocks. Using exponential distributions as priors for clocks, we analyze how well one can keep time with a single qubit freely precessing under a magnetic field. We find that, at least with a single qubit, quantum mechanics does not allow exact timekeeping, in contrast to classical mechanics, which does. We find the design of the single-qubit clock that leads to maximum accuracy. Further, we find an energy versus accuracy tradeoff—the energy cost is at least kBT times the improvement in accuracy as measured by the entropy reduction in going from the prior distribution to the posterior distribution. We propose a physical realization of the single-qubit clock using charge transport across a capacitively coupled quantum dot.

Age-associated disruption of molecular clock expression in skeletal muscle of the spontaneously hypertensive rat.

Directory of Open Access Journals (Sweden)

Mitsunori Miyazaki

Full Text Available It is well known that spontaneously hypertensive rats (SHR develop muscle pathologies with hypertension and heart failure, though the mechanism remains poorly understood. Woon et al. (2007 linked the circadian clock gene Bmal1 to hypertension and metabolic dysfunction in the SHR. Building on these findings, we compared the expression pattern of several core-clock genes in the gastrocnemius muscle of aged SHR (80 weeks; overt heart failure compared to aged-matched control WKY strain. Heart failure was associated with marked effects on the expression of Bmal1, Clock and Rora in addition to several non-circadian genes important in regulating skeletal muscle phenotype including Mck, Ttn and Mef2c. We next performed circadian time-course collections at a young age (8 weeks; pre-hypertensive and adult age (22 weeks; hypertensive to determine if clock gene expression was disrupted in gastrocnemius, heart and liver tissues prior to or after the rats became hypertensive. We found that hypertensive/hypertrophic SHR showed a dampening of peak Bmal1 and Rev-erb expression in the liver, and the clock-controlled gene Pgc1α in the gastrocnemius. In addition, the core-clock gene Clock and the muscle-specific, clock-controlled gene Myod1, no longer maintained a circadian pattern of expression in gastrocnemius from the hypertensive SHR. These findings provide a framework to suggest a mechanism whereby chronic heart failure leads to skeletal muscle pathologies; prolonged dysregulation of the molecular clock in skeletal muscle results in altered Clock, Pgc1α and Myod1 expression which in turn leads to the mis-regulation of target genes important for mechanical and metabolic function of skeletal muscle.

Circadian Clocks and the Interaction between Stress Axis and Adipose Function

Directory of Open Access Journals (Sweden)

Isa Kolbe

2015-01-01

Full Text Available Many physiological processes and most endocrine functions show fluctuations over the course of the day. These so-called circadian rhythms are governed by an endogenous network of cellular clocks and serve as an adaptation to daily and, thus, predictable changes in the organism’s environment. Circadian clocks have been described in several tissues of the stress axis and in adipose cells where they regulate the rhythmic and stimulated release of stress hormones, such as glucocorticoids, and various adipokine factors. Recent work suggests that both adipose and stress axis clock systems reciprocally influence each other and adrenal-adipose rhythms may be key players in the development and therapy of metabolic disorders. In this review, we summarize our current understanding of adrenal and adipose tissue rhythms and clocks and how they might interact to regulate energy homoeostasis and stress responses under physiological conditions. Potential chronotherapeutic strategies for the treatment of metabolic and stress disorders are discussed.

Supporting Family Awareness with the Whereabouts Clock

Science.gov (United States)

Sellen, Abigail; Taylor, Alex S.; Kaye, Joseph ‘Jofish'; Brown, Barry; Izadi, Shahram

We report the results of a field trial of a situated awareness device for families called the “Whereabouts Clock”. The Clock displays the location of family members using cellphone data as one of four privacy-preserving, deliberately coarse-grained categories ( HOME, WORK, SCHOOL or ELSEWHERE). The results show that awareness of others through the Clock supports not only family communication and coordination but also more emotive aspects of family life such as reassurance, connectedness, identity and social touch. We discuss how the term “awareness” means many things in practice and highlight the importance of designing not just for family activities, but in order to support the emotional, social and even moral aspects of family life.

The Chip-Scale Atomic Clock - Low-Power Physics Package

Science.gov (United States)

2004-12-01

36th Annual Precise Time and Time Interval (PTTI) Meeting 339 THE CHIP-SCALE ATOMIC CLOCK – LOW-POWER PHYSICS PACKAGE R. Lutwak ...pdf/documents/ds-x72.pdf [2] R. Lutwak , D. Emmons, W. Riley, and R. M. Garvey, 2003, “The Chip-Scale Atomic Clock – Coherent Population Trapping vs...2002, Reston, Virginia, USA (U.S. Naval Observatory, Washington, D.C.), pp. 539-550. [3] R. Lutwak , D. Emmons, T. English, and W. Riley, 2004

Remote atomic clock synchronization via satellites and optical fibers

OpenAIRE

Piester, D.; Rost, M.; Fujieda, M.; Feldmann, T.; Bauch, A.

2011-01-01

In the global network of institutions engaged with the realization of International Atomic Time (TAI), atomic clocks and time scales are compared by means of the Global Positioning System (GPS) and by employing telecommunication satellites for two-way satellite time and frequency transfer (TWSTFT). The frequencies of the state-of-the-art primary caesium fountain clocks can be compared at the level of 10−15 (relative, 1 day averaging) and time scales can be synchronized...

Performance of a 229Thorium solid-state nuclear clock

International Nuclear Information System (INIS)

Kazakov, G A; Schreitl, M; Winkler, G; Schumm, T; Litvinov, A N; Romanenko, V I; Yatsenko, L P; Romanenko, A V

2012-01-01

The 7.8 eV nuclear isomer transition in 229 thorium has been suggested as a clock transition in a new type of optical frequency standard. Here we discuss the construction of a ‘solid-state nuclear clock’ from thorium nuclei implanted into single crystals transparent in the vacuum ultraviolet range. We investigate crystal-induced line shifts and broadening effects for the specific system of calcium fluoride. At liquid nitrogen temperatures, the clock performance will be limited by decoherence due to magnetic coupling of the thorium nuclei to neighboring nuclear moments, ruling out the commonly used Rabi or Ramsey interrogation schemes. We propose clock stabilization based on a fluorescence spectroscopy method and present optimized operation parameters. Taking advantage of the large number of quantum oscillators under continuous interrogation, a fractional instability level of 10 −19 might be reached within the solid-state approach. (paper)

CIRCADIAN CLOCK-ASSOCIATED 1 Inhibits Leaf Senescence in Arabidopsis

Directory of Open Access Journals (Sweden)

Yi Song

2018-03-01

Full Text Available Leaf senescence is an integral part of plant development, and the timing and progressing rate of senescence could substantially affect the yield and quality of crops. It has been known that a circadian rhythm synchronized with external environmental cues is critical for the optimal coordination of various physiological and metabolic processes. However, the reciprocal interactions between the circadian clock and leaf senescence in plants remain unknown. Here, through measuring the physiological and molecular senescence related markers of several circadian components mutants, we found that CIRCADIAN CLOCK-ASSOCIATED 1 inhibits leaf senescence. Further molecular and genetic studies revealed that CCA1 directly activates GLK2 and suppresses ORE1 expression to counteract leaf senescence. As plants age, the expression and periodic amplitude of CCA1 declines and thus weakens the inhibition of senescence. Our findings reveal an age-dependent circadian clock component of the process of leaf senescence.

Faraday-Shielded dc Stark-Shift-Free Optical Lattice Clock

Science.gov (United States)

Beloy, K.; Zhang, X.; McGrew, W. F.; Hinkley, N.; Yoon, T. H.; Nicolodi, D.; Fasano, R. J.; Schäffer, S. A.; Brown, R. C.; Ludlow, A. D.

2018-05-01

We demonstrate the absence of a dc Stark shift in an ytterbium optical lattice clock. Stray electric fields are suppressed through the introduction of an in-vacuum Faraday shield. Still, the effectiveness of the shielding must be experimentally assessed. Such diagnostics are accomplished by applying high voltage to six electrodes, which are grounded in normal operation to form part of the Faraday shield. Our measurements place a constraint on the dc Stark shift at the 10-20 level, in units of the clock frequency. Moreover, we discuss a potential source of error in strategies to precisely measure or cancel nonzero dc Stark shifts, attributed to field gradients coupled with the finite spatial extent of the lattice-trapped atoms. With this consideration, we find that Faraday shielding, complemented with experimental validation, provides both a practically appealing and effective solution to the problem of dc Stark shifts in optical lattice clocks.

PDF and cAMP enhance PER stability in Drosophila clock neurons

Science.gov (United States)

Li, Yue; Guo, Fang; Shen, James; Rosbash, Michael

2014-01-01

The neuropeptide PDF is important for Drosophila circadian rhythms: pdf01 (pdf-null) animals are mostly arrhythmic or short period in constant darkness and have an advanced activity peak in light–dark conditions. PDF contributes to the amplitude, synchrony, as well as the pace of circadian rhythms within clock neurons. PDF is known to increase cAMP levels in PDR receptor (PDFR)-containing neurons. However, there is no known connection of PDF or of cAMP with the Drosophila molecular clockworks. We discovered that the mutant period gene perS ameliorates the phenotypes of pdf-null flies. The period protein (PER) is a well-studied repressor of clock gene transcription, and the perS protein (PERS) has a markedly short half-life. The result therefore suggests that the PDF-mediated increase in cAMP might lengthen circadian period by directly enhancing PER stability. Indeed, increasing cAMP levels and cAMP-mediated protein kinase A (PKA) activity stabilizes PER, in S2 tissue culture cells and in fly circadian neurons. Adding PDF to fly brains in vitro has a similar effect. Consistent with these relationships, a light pulse causes more prominent PER degradation in pdf01 circadian neurons than in wild-type neurons. The results indicate that PDF contributes to clock neuron synchrony by increasing cAMP and PKA, which enhance PER stability and decrease clock speed in intrinsically fast-paced PDFR-containing clock neurons. We further suggest that the more rapid degradation of PERS bypasses PKA regulation and makes the pace of clock neurons more uniform, allowing them to avoid much of the asynchrony caused by the absence of PDF. PMID:24707054

Cellular Reprogramming–Turning the Clock Back

Indian Academy of Sciences (India)

Home; Journals; Resonance – Journal of Science Education; Volume 18; Issue 6. Cellular Reprogramming - Turning the Clock Back - Nobel Prize in Physiology or Medicine, 2012. Deepa Subramanyam. General Article Volume 18 Issue 6 June 2013 pp 514-521 ...

Peripheral Skin Temperature and Circadian Biological Clock in Shift Nurses after a Day off

Directory of Open Access Journals (Sweden)

Massimo Bracci

2016-04-01

Full Text Available The circadian biological clock is essentially based on the light/dark cycle. Some people working with shift schedules cannot adjust their sleep/wake cycle to the light/dark cycle, and this may result in alterations of the circadian biological clock. This study explored the circadian biological clock of shift and daytime nurses using non-invasive methods. Peripheral skin temperature, cortisol and melatonin levels in saliva, and Per2 expression in pubic hair follicle cells were investigated for 24 h after a day off. Significant differences were observed in peripheral skin temperature and cortisol levels between shift and daytime nurses. No differences in melatonin levels were obtained. Per2 maximum values were significantly different between the two groups. Shift nurses exhibited lower circadian variations compared to daytime nurses, and this may indicate an adjustment of the circadian biological clock to continuous shift schedules. Non-invasive procedures, such as peripheral skin temperature measurement, determination of cortisol and melatonin in saliva, and analysis of clock genes in hair follicle cells, may be effective approaches to extensively study the circadian clock in shift workers.

0.75 atoms improve the clock signal of 10,000 atoms

DEFF Research Database (Denmark)

Kruse, I.; Lange, K.; Peise, Jan

2017-01-01

Since the pioneering work of Ramsey, atom interferometers are employed for precision metrology, in particular to measure time and to realize the second. In a classical interferometer, an ensemble of atoms is prepared in one of the two input states, whereas the second one is left empty. In this case.......75 atoms to improve the clock sensitivity of 10,000 atoms by 2.05 dB. The SQL poses a significant limitation for today's microwave fountain clocks, which serve as the main time reference. We evaluate the major technical limitations and challenges for devising a next generation of fountain clocks based...... on atomic squeezed vacuum....

The AGS Ggamma Meter and Calibrating the Gauss Clock

Energy Technology Data Exchange (ETDEWEB)

Ahrens, Leif [Brookhaven National Laboratory (BNL), Upton, NY (United States). Collider-Accelerator Dept.

2014-03-31

During AGS Polarized Proton acceleration periods, one output from the AGS Ggamma Meter, namely the energy (or Ggamma) calculated from the magnetic field in the AGS main magnets and the beam radius- both measured in particular instant, is used to figure out the times in the AGS magnet acceleration cycle when the beam passes through a particular set of depolarizing resonances. The resonance set occur whenever a particle’s Ggamma (energy*(G/m) becomes nearly equal to n*Qx (i.e. any integer multiplied by the horizontal betatron tune). This deliverable is why the machinery is referred to as the ''Ggamma Meter'' rather than the AGS energy meter. The Ggamma Meter takes as inputs a set of measurements of frequency (F(t)), radius (r(t)), and gauss clock counts (GCC(t)). The other energy (GgammaBr) assumes the field when the gauss clock starts counting is known. The change in field to time t is given by the measured accumulated gauss clock counts multiplied by the gauss clock calibration (gauss/GCC). In order to deal with experimental data, this calibration factor gets an added ad hoc complication, namely a correction dependent on the rate of change the counting rate. The Ggamma meter takes GCC(t) and together with the past history for this cycle calculates B(t).

The AGS Ggamma Meter and Calibrating the Gauss Clock

International Nuclear Information System (INIS)

Ahrens, Leif

2014-01-01

During AGS Polarized Proton acceleration periods, one output from the AGS Ggamma Meter, namely the energy (or Ggamma) calculated from the magnetic field in the AGS main magnets and the beam radius- both measured in particular instant, is used to figure out the times in the AGS magnet acceleration cycle when the beam passes through a particular set of depolarizing resonances. The resonance set occur whenever a particle's Ggamma (energy*(G/m) becomes nearly equal to n*Qx (i.e. any integer multiplied by the horizontal betatron tune). This deliverable is why the machinery is referred to as the ''Ggamma Meter'' rather than the AGS energy meter. The Ggamma Meter takes as inputs a set of measurements of frequency (F(t)), radius (r(t)), and gauss clock counts (GCC(t)). The other energy (GgammaBr) assumes the field when the gauss clock starts counting is known. The change in field to time t is given by the measured accumulated gauss clock counts multiplied by the gauss clock calibration (gauss/GCC). In order to deal with experimental data, this calibration factor gets an added ad hoc complication, namely a correction dependent on the rate of change the counting rate. The Ggamma meter takes GCC(t) and together with the past history for this cycle calculates B(t).

Screening for cognitive dysfunction in Huntington's disease with the clock drawing test.