76 FR 45308 - Self-Regulatory Organizations; The NASDAQ Stock Market LLC; Order Granting Approval of Proposed...

Science.gov (United States)

2011-07-28

...-Regulatory Organizations; The NASDAQ Stock Market LLC; Order Granting Approval of Proposed Rule Change To... change should provide NOM Participants assistance in effectively managing their quotations. \\6\\ 15 U.S.C...,\\2\\ a proposed rule change to adopt a new risk monitor mechanism. The proposed rule change was...

78 FR 62834 - Self-Regulatory Organizations; The NASDAQ Stock Market LLC; Order Granting Approval of Proposed...

Science.gov (United States)

2013-10-22

... Fund of First Trust Exchange-Traded Fund VII October 9, 2013. I. Introduction On August 16, 2013, The... for the provision of custody, transfer agency, and accounting agent services with the same or with...-Regulatory Organizations; The NASDAQ Stock Market LLC; Order Granting Approval of Proposed Rule Change...

European Marketing Authorizations Granted Based on a Single Pivotal Clinical Trial: The Rule or the Exception?

Science.gov (United States)

Morant, Anne Vinther; Vestergaard, Henrik Tang

2018-07-01

A minimum of two positive, adequate, and well-controlled clinical trials has historically been the gold standard for providing substantial evidence to support regulatory approval of a new medicine. Nevertheless, the present analysis of European Marketing Authorizations granted between 2012 and 2016 showed that 45% of new active substances were approved based on a single pivotal clinical trial. For therapeutic areas such as oncology and cardiovascular diseases, approvals based on a single pivotal trial are the rule rather than the exception, whereas new medicines within the nervous system area were generally supported by two or more pivotal trials. While overall similar trends have been observed in the US, the recent US Food and Drug Administration approvals of nervous system medicines based on a single pivotal trial suggest that a case-by-case scientific evaluation of the totality of evidence is increasingly applied to facilitate faster access of new medicines to patients suffering from serious diseases. © 2017 American Society for Clinical Pharmacology and Therapeutics.

How much market do market-based instruments create? An analysis for the case of 'white' certificates

International Nuclear Information System (INIS)

Langniss, Ole; Praetorius, Barbara

2006-01-01

Among the diverse economic instruments to foster energy efficiency (EE) and climate protection, tradable certificates have been investigated for renewable energy, and the EU directive on an emissions-trading scheme for CO 2 certificates has been approved in 2003. In contrast, tradable energy efficiency-or 'white'-certificates have only lately been considered as a market-based tool to foster EE as compared with standards and labelling, for example. Theoretically, there is little doubt about the advantages. In practice, however, some fundamental problems arise. Critical issues are the design of an efficient artificial market for white certificates, its compatibility with the European emissions-trading system, the identification of a suitable target group for an EE obligation and the measurement of energy savings as compared with a reference use of energy. We use the theoretical framework of transaction cost economics to elaborate these issues. We conclude that transaction costs and investment specificity will restrict markets for white certificates in practice. Long-term contracts rather than spot trade will be the prevailing form of governance for EE investments. (author)

Analysis of the Risks and Benefits of New Chemical Entities Approved by the US Food and Drug Administration (FDA) and Subsequently Withdrawn From the US Market.

Science.gov (United States)

Patriarca, Peter A; Van Auken, R Michael; Kebschull, Scott A

2018-01-01

Benefit-risk evaluations of drugs have been conducted since the introduction of modern regulatory systems more than 50 years ago. Such judgments are typically made on the basis of qualitative or semiquantitative approaches, often without the aid of quantitative assessment methods, the latter having often been applied asymmetrically to place emphasis on benefit more so than harm. In an effort to preliminarily evaluate the utility of lives lost or saved, or quality-adjusted life-years (QALY) lost and gained as a means of quantitatively assessing the potential benefits and risks of a new chemical entity, we focused our attention on the unique scenario in which a drug was initially approved based on one set of data, but later withdrawn from the market based on a second set of data. In this analysis, a dimensionless risk to benefit ratio was calculated in each instance, based on the risk and benefit quantified in similar units. The results indicated that FDA decisions to approve the drug corresponded to risk to benefit ratios less than or equal to 0.136, and that decisions to withdraw the drug from the US market corresponded to risk to benefit ratios greater than or equal to 0.092. The probability of FDA approval was then estimated using logistic regression analysis. The results of this analysis indicated that there was a 50% probability of FDA approval if the risk to benefit ratio was 0.121, and that the probability approaches 100% for values much less than 0.121, and the probability approaches 0% for values much greater than 0.121. The large uncertainty in these estimates due to the small sample size and overlapping data may be addressed in the future by applying the methodology to other drugs.

Accelerated approval of oncology products: the food and drug administration experience.

Science.gov (United States)

Johnson, John R; Ning, Yang-Min; Farrell, Ann; Justice, Robert; Keegan, Patricia; Pazdur, Richard

2011-04-20

We reviewed the regulatory history of the accelerated approval process and the US Food and Drug Administration (FDA) experience with accelerated approval of oncology products from its initiation in December 11, 1992, to July 1, 2010. The accelerated approval regulations allowed accelerated approval of products to treat serious or life-threatening diseases based on surrogate endpoints that are reasonably likely to predict clinical benefit. Failure to complete postapproval trials to confirm clinical benefit with due diligence could result in removal of the accelerated approval indication from the market. From December 11, 1992, to July 1, 2010, the FDA granted accelerated approval to 35 oncology products for 47 new indications. Clinical benefit was confirmed in postapproval trials for 26 of the 47 new indications, resulting in conversion to regular approval. The median time between accelerated approval and regular approval of oncology products was 3.9 years (range = 0.8-12.6 years) and the mean time was 4.7 years, representing a substantial time savings in terms of earlier availability of drugs to cancer patients. Three new indications did not show clinical benefit when confirmatory postapproval trials were completed and were subsequently removed from the market or had restricted distribution plans implemented. Confirmatory trials were not completed for 14 new indications. The five longest intervals from receipt of accelerated approval to July 1, 2010, without completion of trials to confirm clinical benefit were 10.5, 6.4, 5.5, 5.5, and 4.7 years. The five longest intervals between accelerated approval and successful conversion to regular approval were 12.6, 9.7, 8.1, 7.5, and 7.4 years. Trials to confirm clinical benefit should be part of the drug development plan and should be in progress at the time of an application seeking accelerated approval to prevent an ineffective drug from remaining on the market for an unacceptable time.

Policy plan for the early approval for irradiated meat products and the promotion of irradiated meats in market

Energy Technology Data Exchange (ETDEWEB)

Lee, Ju Woon [Team for Radiation Food Science and Biotechnology, Advanced Radiation Technology Institute, Korea Atomic Energy Research Institute, Jeongeup (Korea, Republic of); Kim, Wang Geun [Ministry of Education, Science and Technology, Seoul (Korea, Republic of); Kim, Kyong Su [Dept. of Food and Nutrition, Chosun University, Gwangju (Korea, Republic of); Yook, Hong Sun [Dept. of Food and Nutrition, Chungnam National University, Daejeon (Korea, Republic of); Kim, Cheon Jei [Division of Animal Life Science, Konkuk University, Seoul (Korea, Republic of)

2008-11-15

The consumption of meat products is gradually being increased by the development of livestock raising technology, industrialized farm management and international trade. This increased consumption also created new market for ready-to-eat and ready-to-cook meat products. However, these convenience meat products can be easily contaminated during the processing and storage by pathogens, and there have been many reported cases of food borne illness by meats. One of the most effective methods for the decontamination of meat products is the radiation technology. Food irradiation was the established, well-recognized and safe sterilization method. Many other countries researched the effect of irradiation on the meat products and approved the irradiation. In this article, the effectiveness, the international acceptance, the economics and the research trend of irradiation on meat products have been reviewed. Also, the policy plans for the early approval of the irradiated meat products in Korea and the promotion policy of irradiated meats in market were discussed.

Policy plan for the early approval for irradiated meat products and the promotion of irradiated meats in market

International Nuclear Information System (INIS)

Lee, Ju Woon; Kim, Wang Geun; Kim, Kyong Su; Yook, Hong Sun; Kim, Cheon Jei

2008-01-01

The consumption of meat products is gradually being increased by the development of livestock raising technology, industrialized farm management and international trade. This increased consumption also created new market for ready-to-eat and ready-to-cook meat products. However, these convenience meat products can be easily contaminated during the processing and storage by pathogens, and there have been many reported cases of food borne illness by meats. One of the most effective methods for the decontamination of meat products is the radiation technology. Food irradiation was the established, well-recognized and safe sterilization method. Many other countries researched the effect of irradiation on the meat products and approved the irradiation. In this article, the effectiveness, the international acceptance, the economics and the research trend of irradiation on meat products have been reviewed. Also, the policy plans for the early approval of the irradiated meat products in Korea and the promotion policy of irradiated meats in market were discussed

Post-marketing research and its outcome for novel anticancer agents approved by both the FDA and EMA between 2005 and 2010: A cross-sectional study.

Science.gov (United States)

Zeitoun, Jean-David; Baron, Gabriel; Vivot, Alexandre; Atal, Ignacio; Downing, Nicholas S; Ross, Joseph S; Ravaud, Philippe

2018-01-15

Post-marketing research in oncology has rarely been described. We aimed to characterize post-marketing trials for a consistent set of anticancer agents over a long period. We performed a cross-sectional analysis of post-marketing trials registered at ClinicalTrials.gov through September 2014 for novel anticancer agents approved by both the US Food and Drug Administration and the European Medicines Agency between 2005 and 2010. All relevant post-marketing trials were classified according to indication, primary outcome, starting date, sponsors, and planned enrollment. Supplemental indications were retrieved from regulatory documents and publication rate was assessed by two different methods. Ten novel anticancer agents were eligible: five were indicated for hematologic malignancies and the remaining five for solid cancers (three for kidney cancer). We identified 2,345 post-marketing trials; 1,362 (58.1%) targeted an indication other than the originally approved one. We observed extreme variations among drugs in both number of post-marketing trials (range 8-530) and overall population to be enrolled per trial (1-8,381). Post-marketing trials assessed almost all types of cancers, the three most frequently studied cancers being leukemia, kidney cancer and myeloma. In all, 6.6% of post-marketing trials had a clinical endpoint as a primary outcome, and 35.9% and 54.1% had a safety or surrogate endpoint, respectively, as a primary outcome. Nine drugs obtained approval for supplemental indications. The publication rate at 10 years was 12.3 to 26.1% depending on the analysis method. In conclusion, we found that post-marketing research in oncology is highly heterogeneous and the publication rate of launched trials is low. © 2017 UICC.

78 FR 55057 - Authority To Manufacture Carbon Fiber for the U.S. Market Not Approved; Foreign-Trade Subzone...

Science.gov (United States)

2013-09-09

... DEPARTMENT OF COMMERCE Foreign-Trade Zones Board [Order No. 1914] Authority To Manufacture Carbon... behalf of Toho Tenax America, Inc. (TTA), to manufacture carbon fiber under zone procedures for the U.S... approve the application requesting authority to manufacture carbon fiber for the U.S. market under zone...

Evaluation of Pre-marketing Factors to Predict Post-marketing Boxed Warnings and Safety Withdrawals.

Science.gov (United States)

Schick, Andreas; Miller, Kathleen L; Lanthier, Michael; Dal Pan, Gerald; Nardinelli, Clark

2017-06-01

An important goal in drug regulation is understanding serious safety issues with new drugs as soon as possible. Achieving this goal requires us to understand whether information provided during the Food and Drug Administration (FDA) drug review can predict serious safety issues that are usually identified after the product is approved. However, research on this topic remains understudied. In this paper, we examine whether any pre-marketing drug characteristics are associated with serious post-marketing safety actions. We study this question using an internal FDA database containing every new small molecule drug submitted to the FDA's Center for Drug Evaluation and Research (CDER) on or after November 21, 1997, and approved and commercially launched before December 31, 2009. Serious post-marketing safety actions include whether these drugs ever experienced either a post-marketing boxed warning or a withdrawal from the market due to safety concerns. A random effects logistic regression model was used to test whether any pre-marketing characteristics were associated with either post-marketing safety action. A total of 219 new molecular entities were analyzed. Among these drugs, 11 experienced a safety withdrawal and 30 received boxed warnings by July 31, 2016. Contrary to prevailing hypotheses, we find that neither clinical trial sample sizes nor review time windows are associated with the addition of a post-marketing boxed warning or safety withdrawal. However, we do find that new drugs approved with either a boxed warning or priority review are more likely to experience post-marketing boxed warnings. Furthermore, drugs approved with boxed warnings tend to receive post-marketing boxed warnings resulting from new safety information that are unrelated to the original warning. Drugs approved with a boxed warning are 3.88 times more likely to receive a post-marketing boxed warning, while drugs approved with a priority review are 3.51 times more likely to receive a post-marketing

A drug's life: the pathway to drug approval.

Science.gov (United States)

Keng, Michael K; Wenzell, Candice M; Sekeres, Mikkael A

2013-10-01

In the United States, drugs and medical devices are regulated by the US Food and Drug Administration (FDA). A drug must undergo rigorous testing prior to marketing to and medical use by the general public. The FDA grants marketing approval for drug products based on a comprehensive review of safety and efficacy data. This review article explains the history behind the establishment of the FDA and examines the historical legislation and approval processes for drugs, specifically in the fields of medical oncology and hematology. The agents imatinib (Gleevec, Novartis) and decitabine (Dacogen, Eisai) are used to illustrate both the current FDA regulatory process-specifically the orphan drug designation and accelerated approval process-and why decitabine failed to gain an indication for acute myeloid leukemia. The purpose and construct of the Oncologic Drugs Advisory Committee are also discussed, along with examples of 2 renal cell cancer drugs-axitinib (Inlyta, Pfizer) and tivozanib-that used progression-free survival as an endpoint. Regulatory approval of oncology drugs is the cornerstone of the development of new treatment agents and modalities, which lead to improvements in the standard of cancer care. The future landscape of drug development and regulatory approval will be influenced by the new breakthrough therapy designation, and choice of drug will be guided by genomic insights.

Vocations: The Link between Post-Compulsory Education and the Labour Market. What the Research Says For... Qualification & Approval Bodies

Science.gov (United States)

Wheelahan, Leesa; Buchanan, John; Yu, Serena

2015-01-01

This summary pulls together the relevant key findings for qualification and approval bodies from the research program "Vocations: The Link between Post-Compulsory Education and the Labour Market." The program was comprised of three different strands: (1) pathways from VET in Schools, (2) pathways within and between vocational education…

76 FR 77998 - Market Access Agreement

Science.gov (United States)

2011-12-15

... FARM CREDIT ADMINISTRATION Market Access Agreement AGENCY: Farm Credit Administration. ACTION: Notice of approval of the Draft Second Amended and Restated Market Access Agreement. SUMMARY: The Farm Credit Administration (FCA) announces that it has approved the Draft Second Amended and Restated Market...

30 CFR 14.7 - Approval marking and distribution records.

Science.gov (United States)

2010-07-01

..., EVALUATION, AND APPROVAL OF MINING PRODUCTS REQUIREMENTS FOR THE APPROVAL OF FLAME-RESISTANT CONVEYOR BELTS General Provisions § 14.7 Approval marking and distribution records. (a) An approved conveyor belt must be marketed only under the name specified in the approval. (b) Approved conveyor belt must be legibly and...

Pharmaceutical market access in emerging markets: concepts, components, and future.

Science.gov (United States)

Kumar, Anuj; Juluru, Karthaveerya; Thimmaraju, Phani Kishore; Reddy, Jayachandra; Patil, Anand

2014-01-01

This article intends to consolidate the concepts of pharmaceutical market access and highlight its growing importance in emerging markets. Market access has gained considerable attention worldwide as countries try to contain their escalating healthcare expenditures amidst the global economic slowdown. This has resulted in governments adopting stricter measures for new product approval. Thus, pharmaceutical companies are finding it increasingly difficult to successfully address the specific challenges posed by various government and regulatory agencies and stakeholders. There is an increasing need to establish market access functions, especially in emerging markets, where the complex, dynamic healthcare landscape confounds product approval and uptake. Moreover, emerging markets are the engines of growth today, and, thus, performing in these markets is critical for the majority of pharmaceutical companies. To address the challenges posed by regulatory agencies and diverse stakeholders, a customized market access strategy is the need of the hour. A market access framework with specific tools and tactics will help companies to plan, implement, and monitor stakeholder engagement activities.

17 CFR 1.54 - Contract market rules submitted to and approved or not disapproved by the Secretary of Agriculture.

Science.gov (United States)

2010-04-01

... submitted to and approved or not disapproved by the Secretary of Agriculture. 1.54 Section 1.54 Commodity... Secretary of Agriculture. Notwithstanding any provision of these rules, any bylaw, rule, regulation, or resolution of a contract market that was submitted to the Secretary of Agriculture pursuant or § 1.38(a) or...

7 CFR 996.22 - USDA-approved laboratory.

Science.gov (United States)

2010-01-01

..., Agricultural Marketing Service, USDA, that chemically analyze peanuts for aflatoxin content. Quality and... 7 Agriculture 8 2010-01-01 2010-01-01 false USDA-approved laboratory. 996.22 Section 996.22 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Marketing...

7 CFR 1425.4 - Approval.

Science.gov (United States)

2010-01-01

... AGRICULTURE LOANS, PURCHASES, AND OTHER OPERATIONS COOPERATIVE MARKETING ASSOCIATIONS § 1425.4 Approval. (a) For a cooperative to gain CMA status to participate in a marketing assistance loan or Loan deficiency... prepared in accordance with generally accepted accounting principles; (3) A copy of the articles of...

7 CFR 966.124 - Approved receiver.

Science.gov (United States)

2010-01-01

... limited to, the following information: (1) Name, address, contact person, telephone number, and e-mail... 7 Agriculture 8 2010-01-01 2010-01-01 false Approved receiver. 966.124 Section 966.124 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Marketing Agreements...

Heterogeneity of Clinical Trials for Antihypertensive Drugs in Japan: Exploratory Analysis of Confirmatory Phase III Trials Used for Marketing Approval.

Science.gov (United States)

Kaneko, Reina; Sano, Kota; Ono, Shunsuke

2018-07-01

The results of pivotal trials, which provide a rationale for marketing approval decisions for new drugs, are considered for various comparative purposes in postmarketing analyses. Using meta-regression analysis of 91 randomized controlled trials of 61 approved antihypertensive drugs in Japan, we show that mean baseline blood pressure (BP) of each arm was associated with predetermined entry criteria (EC), age, and trial start year (TSY). BP changes following treatment were associated with EC, subject characteristics (e.g., age, complications, baseline BP), study design (e.g., concomitant drug use), and TSY. Effect sizes were generally larger in trials for the first and second drugs in the same class than in trials for follow-on drugs. Results of pivotal trials may vary depending on many factors, suggesting possible challenges associated with the comparison of these results indirectly. Due to the heterogeneity in pivotal trials, caution should be exercised when comparing approved drugs and conducting meta-analyses retrospectively. © 2017, The American Society for Clinical Pharmacology and Therapeutics.

24 CFR 886.107 - Approval of applications.

Science.gov (United States)

2010-04-01

...) The Owner's Affirmative Fair Housing Marketing Plan is approvable. (b) The HUD-approved unit rents are... climatic or geological conditions or local codes are examples which may justify such variations. (d) A... neighborhood in a substantially adverse manner. Examples of such adverse effects are (1) substantial move-outs...

Linaclotide: first global approval.

Science.gov (United States)

McWilliams, Vanessa; Whiteside, Glenn; McKeage, Kate

2012-11-12

Linaclotide is a once-daily, orally administered, first-in-class agonist of guanylate cyclase-C that is minimally absorbed. It is being developed to treat gastrointestinal disorders by Ironwood Pharmaceuticals and its partners, Forest Laboratories (North America), Almirall (Europe) and Astellas Pharma (Asia-Pacific). Linaclotide has received its first global approval in the US for the treatment of constipation-predominant irritable bowel syndrome (IBS-C) and chronic idiopathic constipation (CIC), and a marketing submission has been filed in the EU for IBS-C. This article summarizes the milestones in the development of linaclotide leading to this first approval for IBS-C and CIC. This profile has been extracted and modified from the Adis R&D Insight drug pipeline database. Adis R&D Insight tracks drug development worldwide through the entire development process, from discovery, through pre-clinical and clinical studies to market launch.

Is It Really FDA Approved?

Science.gov (United States)

... satisfaction before companies can market them in interstate commerce. Some examples of biologics that require approval are ... it means the agency has determined that the benefits of the product outweigh the known risks for ...

24 CFR 886.321 - Marketing.

Science.gov (United States)

2010-04-01

... 24 Housing and Urban Development 4 2010-04-01 2010-04-01 false Marketing. 886.321 Section 886.321... the Disposition of HUD-Owned Projects § 886.321 Marketing. (a) Marketing in accordance with HUD-Approved Plan. Marketing of units and selection of families by the owner shall be in accordance with the...

75 FR 36058 - Notice of Request for Extension and Revision of a Currently Approved Information Collection

Science.gov (United States)

2010-06-24

... Currently Approved Information Collection AGENCY: Agricultural Marketing Service, USDA. ACTION: Notice and...: Extension and revision of a currently approved information collection. Abstract: Marketing order programs... / Thursday, June 24, 2010 / Notices#0;#0; [[Page 36058

75 FR 32355 - Notice of Request for Revision of a Currently Approved Information Collection

Science.gov (United States)

2010-06-08

.... Expiration Date of Approval: November 30, 2010. Type of Request: Revision of a currently approved information... retailers to market product. The Agricultural Marketing Act of 1946 (7 U.S.C. 1621-1627), section 203(g... ornamental trade, which includes packers, processors, brokers, retailers, producers, and associated...

Forecasting Housing Approvals in Australia: Do Forecasters Herd?

DEFF Research Database (Denmark)

Stadtmann, Georg; Pierdzioch; Rülke

2012-01-01

Price trends in housing markets may reflect herding of market participants. A natural question is whether such herding, to the extent that it occurred, reflects herding in forecasts of professional forecasters. Using more than 6,000 forecasts of housing approvals for Australia, we did not find...

Market based generation: A promising market management option

International Nuclear Information System (INIS)

Siddiqi, R.

1992-01-01

It is proposed to ease the tension between demand management and supply side management at electric utilities through the introduction of a concept called market management. Market management provides a framework for developing and evaluating the attractiveness of new products and services such as dispersed generation hardware, implementation services, and complementary pricing structures. A market management strategy is the definition of market segments, creating products for those segments, evaluation of the profitability of the product-segment combinations, commitment of resources to those segments, and development of product and marketing plans for those segments. A brief analysis of backup generation is presented as an example of market management. In this example, the customer that is backed up shares some portion of the capital and maintenance costs of the backup unit through priority service rates; the utility and customers that are not backed up can obtain the use of the generating resource but pay only a portion of its costs. Backup generation programs have been found to provide utilities with the ability to meet peak load requirements more cheaply than by investing in peaking capacity. Other benefits for utilities include protection of market share, more efficient rates, and a new source of revenues. With the advances in the technology of small-scale generation, utilities can examine bundling various pricing options with market based generation to offer alternative value-added service options to customer segments with demand characteristics that make these technologies attractive. 3 figs

Desiccant-Based Preconditioning Market Analysis

Energy Technology Data Exchange (ETDEWEB)

Fischer, J.

2001-01-11

A number of important conclusions can be drawn as a result of this broad, first-phase market evaluation. The more important conclusions include the following: (1) A very significant market opportunity will exist for specialized outdoor air-handling units (SOAHUs) as more construction and renovation projects are designed to incorporate the recommendations made by the ASHRAE 62-1989 standard. Based on this investigation, the total potential market is currently $725,000,000 annually (see Table 6, Sect. 3). Based on the market evaluations completed, it is estimated that approximately $398,000,000 (55%) of this total market could be served by DBC systems if they were made cost-effective through mass production. Approximately $306,000,000 (42%) of the total can be served by a non-regenerated, desiccant-based total recovery approach, based on the information provided by this investigation. Approximately $92,000,000 (13%) can be served by a regenerated desiccant-based cooling approach (see Table 7, Sect. 3). (2) A projection of the market selling price of various desiccant-based SOAHU systems was prepared using prices provided by Trane for central-station, air-handling modules currently manufactured. The wheel-component pricing was added to these components by SEMCO. This resulted in projected pricing for these systems that is significantly less than that currently offered by custom suppliers (see Table 4, Sect. 2). Estimated payback periods for all SOAHU approaches were quite short when compared with conventional over-cooling and reheat systems. Actual paybacks may vary significantly depending on site-specific considerations. (3) In comparing cost vs benefit of each SOAHU approach, it is critical that the total system design be evaluated. For example, the cost premium of a DBC system is very significant when compared to a conventional air handling system, yet the reduced chiller, boiler, cooling tower, and other expense often equals or exceeds this premium, resulting in a

Value-Based Marketing: A Dsicussion of Issues and Trends in the Slaughter Cattle Market

OpenAIRE

Fausti, Scott W.; Diersen, Matthew A.; Qasmi, Bashir A.; Li, Jing

2009-01-01

Pricing and technological innovation are discussed within the context of the beef industry’s value-based marketing initiative. Cash and contract marketing practices for fed cattle are addressed with respect to slaughter volume and pricing methods (live, dressed, and grid). A methodology for estimating grid market share of weekly slaughter volume, based on USDA market reports (2004–2009), is introduced. Weekly grid market shares for the cash and contract markets are derived. Summary statis...

Intervening in global markets to improve access to HIV/AIDS treatment: an analysis of international policies and the dynamics of global antiretroviral medicines markets.

Science.gov (United States)

Waning, Brenda; Kyle, Margaret; Diedrichsen, Ellen; Soucy, Lyne; Hochstadt, Jenny; Bärnighausen, Till; Moon, Suerie

2010-05-25

Universal access to antiretroviral therapy (ART) in low- and middle-income countries faces numerous challenges: increasing numbers of people needing ART, new guidelines recommending more expensive antiretroviral (ARV) medicines, limited financing, and few fixed-dose combination (FDC) products. Global initiatives aim to promote efficient global ARV markets, yet little is known about market dynamics and the impact of global policy interventions. We utilize several data sources, including 12,958 donor-funded, adult first-line ARV purchase transactions, to describe the market from 2002-2008. We examine relationships between market trends and: World Health Organization (WHO) HIV/AIDS treatment guidelines; WHO Prequalification Programme (WHO Prequal) and United States (US) Food and Drug Administration (FDA) approvals; and procurement policies of the Global Fund to Fight AIDS, Tuberculosis, and Malaria (GFATM), US President's Emergency Plan for AIDS Relief (PEPFAR) and UNITAID. WHO recommended 7, 4, 24, and 6 first-line regimens in 2002, 2003, 2006 and 2009 guidelines, respectively. 2009 guidelines replaced a stavudine-based regimen ($88/person/year) with more expensive zidovudine- ($154-260/person/year) or tenofovir-based ($244-465/person/year) regimens. Purchase volumes for ARVs newly-recommended in 2006 (emtricitabine, tenofovir) increased >15-fold from 2006 to 2008. Twenty-four generic FDCs were quality-approved for older regimens but only four for newer regimens. Generic FDCs were available to GFATM recipients in 2004 but to PEPFAR recipients only after FDA approval in 2006. Price trends for single-component generic medicines mirrored generic FDC prices. Two large-scale purchasers, PEPFAR and UNITAID, together accounted for 53%, 84%, and 77% of market volume for abacavir, emtricitabine, and tenofovir, respectively, in 2008. PEPFAR and UNITAID purchases were often split across two manufacturers. Global initiatives facilitated the creation of fairly efficient markets

18 CFR 300.10 - Application for confirmation and approval.

Science.gov (United States)

2010-04-01

... REGULATORY COMMISSION, DEPARTMENT OF ENERGY REGULATIONS FOR FEDERAL POWER MARKETING ADMINISTRATIONS CONFIRMATION AND APPROVAL OF THE RATES OF FEDERAL POWER MARKETING ADMINISTRATIONS Filing Requirements § 300.10... with applicable laws and that it is the lowest possible rate consistent with sound business principles...

Simulation of sovereign CDS market based on interaction between market participant

Science.gov (United States)

Ko, Bonggyun; Kim, Kyungwon

2017-08-01

A research for distributional property of financial asset is the subject of intense interest not only for financial theory but also for practitioner. Such respect is no exception to CDS market. The CDS market, which began to receive attention since the global financial debacle, is not well researched despite of the importance of research necessity. This research introduces creation of CDS market and use Ising system utilizing occurrence characteristics (to shift risk) as an important factor. Therefore the results of this paper would be of great assistance to both financial theory and practice. From this study, not only distributional property of the CDS market but also various statistics like multifractal characteristics could promote understanding about the market. A salient point in this study is that countries are mainly clustering into 2 groups and it might be because of market situation and geographical characteristics of each country. This paper suggested 2 simulation parameters representing this market based on understanding such CDS market situation. The estimated parameters are suitable for high and low risk event of CDS market respectively and these two parameters are complementary and can cover not only basic statistics but also multifractal properties of most countries. Therefore these estimated parameters can be used in researches preparing for a certain event (high or low risk). Finally this research will serve as a momentum double-checking indirectly the performance of Ising system based on these results.

Market-Based Fisheries Management

DEFF Research Database (Denmark)

Høst, Jeppe Engset

a timely, critical insight into the social, cultural and economic aspects and consequences of market-based fisheries management. The privatization of fish quotas in Denmark represents one of the most far-reaching and comprehensive privatization schemes of its kind and has been widely promoted as a market......-based system with innovative social safeguards. This work critically examines this privatization of fish resources, combining quantitative and qualitative material to provide new understanding of fish quotas and their social value. Scholars with an interest in privatization and the socio-economic aspects...... of fisheries, and those working with NGOs, fishers and fisheries, and concerned with political conflicts will all value the research presented here....

78 FR 49508 - Tesoro Refining & Marketing Company LLC; Supplemental Notice That Initial Market-Based Rate...

Science.gov (United States)

2013-08-14

... Refining & Marketing Company LLC; Supplemental Notice That Initial Market-Based Rate Filing Includes... proceeding of Tesoro Refining & Marketing Company LLC's application for market-based rate authority, with an... of protests and interventions in lieu of paper, using the FERC Online links at http://www.ferc.gov...

75 FR 35017 - Brookfield Energy Marketing LP; Supplemental Notice That Initial Market-Based Rate Filing...

Science.gov (United States)

2010-06-21

... Energy Marketing LP; Supplemental Notice That Initial Market-Based Rate Filing Includes Request for... proceeding of Brookfield Energy Marketing LP's application for market-based rate authority, with an... protests and interventions in lieu of paper, using the FERC Online links at http://www.ferc.gov . To...

78 FR 16262 - Tesoro Refining & Marketing Company LLC; Supplemental Notice That Initial Market-Based Rate...

Science.gov (United States)

2013-03-14

... Refining & Marketing Company LLC; Supplemental Notice That Initial Market-Based Rate Filing Includes... proceeding, of Tesoro Refining & Marketing Company LLC's application for market- based rate authority, with... submission of protests and interventions in lieu of paper, using the FERC Online links at http://www.ferc.gov...

MARKET WATCH

Institute of Scientific and Technical Information of China (English)

无

2010-01-01

TO THE POINT:The government vows to control the real estate market after a year of robust growth.To diversify financial investment tools,the regulatory authorities approved the launch of stock index futures,and short selling and margin trading to allow investors to hedge against risks.China overtakes the United States to become the world’s biggest auto market in2009.The country is also expected to become the largest consumer market in the world by2020.Google threatens to halt its China operations if it cannot reach a censorship agreement with the government.

75 FR 76729 - Market Access Agreement

Science.gov (United States)

2010-12-09

... FARM CREDIT ADMINISTRATION Market Access Agreement AGENCY: Farm Credit Administration. ACTION: Notice of approval of the draft amendment to the amended and restated market access agreement. SUMMARY... Credit Bank of Wichita and the Western Farm Credit Bank under Section 7.12 of the Market Access Agreement...

75 FR 80061 - Abbott Laboratories, Inc.; Withdrawal of Approval of a New Drug Application for MERIDIA

Science.gov (United States)

2010-12-21

... withdrawing approval of a new drug application (NDA) for MERIDIA (sibutramine hydrochloride (HCl)) oral... requested that Abbott voluntarily withdraw MERIDIA (sibutramine HCl) oral capsules from the market, based on FDA's recent analysis of clinical trial data from the Sibutramine Cardiovascular Outcomes Trial (SCOUT...

Number of patients studied prior to approval of new medicines

DEFF Research Database (Denmark)

Duijnhoven, Ruben G; Straus, Sabine M J M; Raine, June M

2013-01-01

length of time), whereas 67 (79.8%) of the medicines met the criteria for 12-mo patient exposure (at least 100 participants studied for 12 mo). CONCLUSIONS: For medicines intended for chronic use, the number of patients studied before marketing is insufficient to evaluate safety and long-term efficacy....... Both safety and efficacy require continued study after approval. New epidemiologic tools and legislative actions necessitate a review of the requirements for the number of patients studied prior to approval, particularly for chronic use, and adequate use of post-marketing studies. Please see later...

Advancement of Marketing Developing Biotechnology-Based Business

Directory of Open Access Journals (Sweden)

Vaidas Vilmantas

2014-09-01

Full Text Available The article, in a complex way, analyzes the needs of marketing improvement in developing biotechnology­based business and highlights its role in the context of modern society and globalization challenges. The article distinguishes between the existing problems of biotechnology business, the present perspectives and specific characteristics of developing the marketing of biotechnological business. The paper represents the possibility of the substantial modernization of marketing tools with regard to modelling user’s behaviour, improvement in marketing strategy for the company, the correction of the elements of the marketing complex, changes in the marketing conception inside the company, product and service differentiation and renewal, the encouragement of expansion into other markets, variations in or the expansion of the target market, alternatives to the positioning strategy for the company, an increase in competitive ability and an internal impact of marketing on the varying elements. The article has referred to the analysis of scientific literature and research on the opinions of consumers and experts in the field in the context of biotechnology­based businesses.

76 FR 58398 - Revised Guidance on Marketed Unapproved Drugs; Compliance Policy Guide Sec. 440.100; Marketed New...

Science.gov (United States)

2011-09-21

... guidance the manufacture and marketing of newly introduced unapproved drugs. This guidance represents the... United States that do not have required FDA approval for marketing. CPG 440.100 has been revised to state..., 2011. All unapproved new drugs introduced onto the market after that date are subject to immediate...

75 FR 29306 - Notice of Request for Extension of a Currently Approved Information Collection

Science.gov (United States)

2010-05-25

... Market News Branch, Livestock and Seed Program, Agricultural Marketing Service, U.S. Department of... DEPARTMENT OF AGRICULTURE Agricultural Marketing Service [Doc. No. AMS-LS-10-0035] Notice of Request for Extension of a Currently Approved Information Collection AGENCY: Agricultural Marketing...

75 FR 5782 - Noble Energy Marketing and Trade Corporation; Supplemental Notice That Initial Market-Based Rate...

Science.gov (United States)

2010-02-04

... Marketing and Trade Corporation; Supplemental Notice That Initial Market-Based Rate Filing Includes Request...-referenced proceeding of Noble Energy Marketing and Trade Corporation's application for market- based rate... electronic submission of protests and interventions in lieu of paper, using the FERC Online links at http...

Segments of marketers based on a perceived importance of marketing knowledge and skills

OpenAIRE

Vesna Žabkar; Maja Hosta

2009-01-01

The purpose of this article is to define and empirically verify a range of knowledge and skills which are necessary in order to segment marketers, based on their perceptions of the importance of such marketing knowledge and skills. To empirically verify the importance of marketing knowledge and skills, a 28-item measurement instrument was developed. Responses from 235 marketing vice-presidents, marketing directors, sales directors or company presidents/owners in Slovenia were obtained (an 11....

77 FR 30274 - Inupiat Energy Marketing, LLC; Supplemental Notice That Initial Market-Based Rate Filing Includes...

Science.gov (United States)

2012-05-22

... Energy Marketing, LLC; Supplemental Notice That Initial Market-Based Rate Filing Includes Request for... Inupiat Energy Marketing, LLC's application for market-based rate authority, with an accompanying rate... protests and interventions in lieu of paper, using the FERC Online links at http://www.ferc.gov . To...

78 FR 56691 - Sapphire Power Marketing LLC; Supplemental Notice That Initial Market-Based Rate Filing Includes...

Science.gov (United States)

2013-09-13

... Power Marketing LLC; Supplemental Notice That Initial Market-Based Rate Filing Includes Request for... Sapphire Power Marketing LLC's application for market-based rate authority, with an accompanying rate... submission of protests and interventions in lieu of paper, using the FERC Online links at http://www.ferc.gov...

75 FR 48666 - Calpine Mid-Atlantic Marketing, LLC; Supplemental Notice That Initial Market-Based Rate Filing...

Science.gov (United States)

2010-08-11

...-Atlantic Marketing, LLC; Supplemental Notice That Initial Market-Based Rate Filing Includes Request for... proceeding, of Calpine Mid-Atlantic Marketing, LLC's application for market-based rate authority, with an... of protests and interventions in lieu of paper, using the FERC Online links at http://www.ferc.gov...

75 FR 24941 - PBF Power Marketing LLC; Supplemental Notice That Initial Market-Based Rate Filing Includes...

Science.gov (United States)

2010-05-06

... Marketing LLC; Supplemental Notice That Initial Market- Based Rate Filing Includes Request for Blanket... of PBF Power Marketing LLC's application for market-based rate authority, with an accompanying rate... protests and interventions in lieu of paper, using the FERC Online links at http://www.ferc.gov . To...

78 FR 28837 - Myotis Power Marketing LLC; Supplemental Notice That Initial Market-Based Rate Filing Includes...

Science.gov (United States)

2013-05-16

... Marketing LLC; Supplemental Notice That Initial Market-Based Rate Filing Includes Request for Blanket... Marketing LLC's application for market-based rate authority, with an accompanying rate schedule, noting that... interventions in lieu of paper, using the FERC Online links at http://www.ferc.gov . To facilitate electronic...

77 FR 53197 - Raven Power Marketing LLC; Supplemental Notice That Initial Market-Based Rate Filing Includes...

Science.gov (United States)

2012-08-31

... Marketing LLC; Supplemental Notice That Initial Market-Based Rate Filing Includes Request for Blanket... Marketing LLC's application for market-based rate authority, with an accompanying rate schedule, noting that... interventions in lieu of paper, using the FERC Online links at http://www.ferc.gov . To facilitate electronic...

78 FR 20910 - Hess Energy Marketing, LLC; Supplemental Notice That Initial Market-Based Rate Filing Includes...

Science.gov (United States)

2013-04-08

... Marketing, LLC; Supplemental Notice That Initial Market-Based Rate Filing Includes Request for Blanket... Marketing, LLC's application for market-based rate authority, with an accompanying rate schedule, noting... interventions in lieu of paper, using the FERC Online links at http://www.ferc.gov . To facilitate electronic...

Utilizing national and international registries to enhance pre-market medical device regulatory evaluation.

Science.gov (United States)

Yue, Lilly Q; Campbell, Gregory; Lu, Nelson; Xu, Yunling; Zuckerman, Bram

2016-01-01

Regulatory decisions are made based on the assessment of risk and benefit of medical devices at the time of pre-market approval and subsequently, when post-market risk-benefit balance needs reevaluation. Such assessments depend on scientific evidence obtained from pre-market studies, post-approval studies, post-market surveillance studies, patient perspective information, as well as other real world data such as national and international registries. Such registries provide real world evidence and are playing a more and more important role in enhancing the safety and effectiveness evaluation of medical devices. While these registries provide large quantities of data reflecting real world practice and can potentially reduce the cost of clinical trials, challenges arise concerning (1) data quality adequate for regulatory decision-making, (2) bias introduced at every stage and aspect of study, (3) scientific validity of study designs, and (4) reliability and interpretability of study results. This article will discuss related statistical and regulatory challenges and opportunities with examples encountered in medical device regulatory reviews.

Intervening in global markets to improve access to HIV/AIDS treatment: an analysis of international policies and the dynamics of global antiretroviral medicines markets

Directory of Open Access Journals (Sweden)

Hochstadt Jenny

2010-05-01

Full Text Available Abstract Background Universal access to antiretroviral therapy (ART in low- and middle-income countries faces numerous challenges: increasing numbers of people needing ART, new guidelines recommending more expensive antiretroviral (ARV medicines, limited financing, and few fixed-dose combination (FDC products. Global initiatives aim to promote efficient global ARV markets, yet little is known about market dynamics and the impact of global policy interventions. Methods We utilize several data sources, including 12,958 donor-funded, adult first-line ARV purchase transactions, to describe the market from 2002-2008. We examine relationships between market trends and: World Health Organization (WHO HIV/AIDS treatment guidelines; WHO Prequalification Programme (WHO Prequal and United States (US Food and Drug Administration (FDA approvals; and procurement policies of the Global Fund to Fight AIDS, Tuberculosis, and Malaria (GFATM, US President's Emergency Plan for AIDS Relief (PEPFAR and UNITAID. Results WHO recommended 7, 4, 24, and 6 first-line regimens in 2002, 2003, 2006 and 2009 guidelines, respectively. 2009 guidelines replaced a stavudine-based regimen ($88/person/year with more expensive zidovudine- ($154-260/person/year or tenofovir-based ($244-465/person/year regimens. Purchase volumes for ARVs newly-recommended in 2006 (emtricitabine, tenofovir increased >15-fold from 2006 to 2008. Twenty-four generic FDCs were quality-approved for older regimens but only four for newer regimens. Generic FDCs were available to GFATM recipients in 2004 but to PEPFAR recipients only after FDA approval in 2006. Price trends for single-component generic medicines mirrored generic FDC prices. Two large-scale purchasers, PEPFAR and UNITAID, together accounted for 53%, 84%, and 77% of market volume for abacavir, emtricitabine, and tenofovir, respectively, in 2008. PEPFAR and UNITAID purchases were often split across two manufacturers. Conclusions Global initiatives

A Tool for Predicting Regulatory Approval After Phase II Testing of New Oncology Compounds.

Science.gov (United States)

DiMasi, J A; Hermann, J C; Twyman, K; Kondru, R K; Stergiopoulos, S; Getz, K A; Rackoff, W

2015-11-01

We developed an algorithm (ANDI) for predicting regulatory marketing approval for new cancer drugs after phase II testing has been conducted, with the objective of providing a tool to improve drug portfolio decision-making. We examined 98 oncology drugs from the top 50 pharmaceutical companies (2006 sales) that first entered clinical development from 1999 to 2007, had been taken to at least phase II development, and had a known final outcome (research abandonment or regulatory marketing approval). Data on safety, efficacy, operational, market, and company characteristics were obtained from public sources. Logistic regression and machine-learning methods were used to provide an unbiased approach to assess overall predictability and to identify the most important individual predictors. We found that a simple four-factor model (activity, number of patients in the pivotal phase II trial, phase II duration, and a prevalence-related measure) had high sensitivity and specificity for predicting regulatory marketing approval. © 2015 American Society for Clinical Pharmacology and Therapeutics.

Pay-as-bid based reactive power market

International Nuclear Information System (INIS)

Amjady, N.; Rabiee, A.; Shayanfar, H.A.

2010-01-01

In energy market clearing, the offers are stacked in increasing order and the offer that intersects demand curve, determines the market clearing price (MCP). In reactive power market, the location of reactive power compensator is so important. A low cost reactive producer may not essentially be favorable if it is far from the consumer. Likewise, a high cost local reactive compensator at a heavily loaded demand center of network could be inevitably an alternative required to produce reactive power to maintain the integrity of power system. Given the background, this paper presents a day-ahead reactive power market based on pay-as-bid (PAB) mechanism. Generators expected payment function (EPF) is used to construct a bidding framework. Then, total payment function (TPF) of generators is used as the objective function of optimal power flow (OPF) problem to clear the PAB based market. The CIGRE-32 bus test system is used to examine the effectiveness of the proposed reactive power market.

Pay-as-bid based reactive power market

Energy Technology Data Exchange (ETDEWEB)

Amjady, N. [Department of Electrical Engineering, Semnan University, Semnan (Iran, Islamic Republic of); Rabiee, A., E-mail: Rabiee@iust.ac.i [Center of Excellence for Power System Automation and Operation, Department of Electrical Engineering, Iran University of Science and Technology, Tehran (Iran, Islamic Republic of); Shayanfar, H.A. [Center of Excellence for Power System Automation and Operation, Department of Electrical Engineering, Iran University of Science and Technology, Tehran (Iran, Islamic Republic of)

2010-02-15

In energy market clearing, the offers are stacked in increasing order and the offer that intersects demand curve, determines the market clearing price (MCP). In reactive power market, the location of reactive power compensator is so important. A low cost reactive producer may not essentially be favorable if it is far from the consumer. Likewise, a high cost local reactive compensator at a heavily loaded demand center of network could be inevitably an alternative required to produce reactive power to maintain the integrity of power system. Given the background, this paper presents a day-ahead reactive power market based on pay-as-bid (PAB) mechanism. Generators expected payment function (EPF) is used to construct a bidding framework. Then, total payment function (TPF) of generators is used as the objective function of optimal power flow (OPF) problem to clear the PAB based market. The CIGRE-32 bus test system is used to examine the effectiveness of the proposed reactive power market.

An approved personal dosimetry service based on an electronic dosimeter

International Nuclear Information System (INIS)

Marshall, T.O.; Bartlett, D.T.; Burgess, P.H.; Campbell, J.I.; Hill, C.E.; Pook, E.A.; Sandford, D.J.

1991-01-01

At the Second Conference on Radiation Protection and Dosimetry a paper was presented which, in part, announced the development of an electronic dosimeter to be undertaken in the UK by the National Radiological Protection Board (NRPB) and Siemens Plessey Controls Ltd. This dosimeter was to be of a standard suitable for use as the basis of an approved personal dosimetry service for photon and beta radiations. The project has progressed extremely well and dosimeters and readers are about to become commercially available. The system and the specification of the dosimeter are presented. The NRPB is in the process of applying for approval by the Health and Safety Executive (HSE) to operate as personal monitoring service based on this dosimeter. As part of the approval procedure the dosimeter is being type tested and is also undergoing an HSE performance test and wearer trials. The tests and the wearer trials are described and a summary of the results to date presented. The way in which the service will be organized and operated is described and a comparison is made between the running of the service and others based on passive dosimeters at NRPB

40 CFR 52.1605 - EPA-approved New Jersey regulations.

Science.gov (United States)

2010-07-01

... of “large zone 3 coal conversions” must be provided to EPA (40 CFR 52.1601(b)). Subchapter 11... Subchapter 16 is approved into the SIP except for Open Market Emissions Trading (OMET) provisions at 16.1A(g... into the SIP except for the following provisions: (1) Open Market Emissions Trading (OMET) provisions...

18 CFR 284.505 - Market-based rates for storage providers without a market-power determination.

Science.gov (United States)

2010-04-01

... 18 Conservation of Power and Water Resources 1 2010-04-01 2010-04-01 false Market-based rates for storage providers without a market-power determination. 284.505 Section 284.505 Conservation of Power and... UNDER THE NATURAL GAS POLICY ACT OF 1978 AND RELATED AUTHORITIES Applications for Market-Based Rates for...

MARKETING CAPABILITIES FOR INNOVATION-BASED COMPETITIVE ADVANTAGE IN THE SLOVENIAN MARKET

Directory of Open Access Journals (Sweden)

Vojko Potocan

2013-01-01

Full Text Available The primary role of marketing within the competitive advantage is innovation. The customer value-based differentiation strategies will drive the company’s market research efforts, its selection of target markets, its product development processes, its market communications programs, and its delivery processes. These processes require many specific capabilities that enable the firm to carry out activities necessary to move its products or services through the value chain. We must explore the role of distinctive marketing capabilities in competitive strategy of the company. As sources of competitive advantage, companies try to create their product or service differentiation by developing higher product or service quality, by using their knowledge to solving marketing problems, by communicating with their customers, and by satisfying customer’s needs. We also would like to confirm that superior customer service lead to company’s innovation. The paper closes with the implications of the findings and highlights promising future research avenues.

Challenges in Albania for improving Labor Market Information System and Labor Market Governance

Directory of Open Access Journals (Sweden)

Neshat Zeneli

2017-07-01

Full Text Available Labour Market Policy of the Republic of Albania in terms of design (preparation, case identification, formulation, and approval, programming and budgeting, implementation, monitoring and evaluation has a short experience (1995-ongoing. The influence and presence of hierarchy model is very high beside the support of different programs and projects through bilateral and EU programs. Still there are a lot of key issues to be addressed. The most important issues to be addressed in this paper are evidence based related to: • The Availability of Labor Market Information and its structure on national, regional and local level in Albania and how much this information is used for -policy making and –monitoring/evaluation in terms of input, output, outcome and impact. • Mode of the governance of the labor market in Albania and challenges to pass from the hierarchy to market and network governance. The main aim of this paper/article is to do a complete and deep analysis of the actual situation of labor market information system and labor market governance in Albania, and to propose conclusions and recommendations that will improve both labor market information system and the labor market governance from hierarchy to market and network governance, because good and standardized labor information system can help towards right policy decisions and good governance of LM policy means more employment, more stability, more social inclusion in the society.

7 CFR 905.54 - Marketing, research and development.

Science.gov (United States)

2010-01-01

... 7 Agriculture 8 2010-01-01 2010-01-01 false Marketing, research and development. 905.54 Section... Marketing, research and development. The committee may, with the approval of the Secretary, establish, or provide for the establishment of, projects including production research, marketing research and...

Comparison of the new Japanese legislation for expedited approval of regenerative medicine products with the existing systems in the USA and European Union.

Science.gov (United States)

Jokura, Yoji; Yano, Kazuo; Yamato, Masayuki

2018-02-01

Legislation for expedited-approval pathways and programmes for drugs, biologics or medical devices has been enacted for rapid commercialization of innovative products in the United States of America (USA) and the European Union (EU). However, less innovative products are increasingly benefitting from these expedited-approval pathways, and obligations to collect and report post-marketing data on approved products are being bypassed frequently. The Japanese government recently enacted legislation for a new conditional and time-limited approval pathway dedicated to regenerative medicine products. The current study examines this new legislation and compares it with existing US and EU regulatory frameworks, with a particular focus on how it addresses the limitations of existing systems. Regulations, guidance documents and approval information were gathered from the websites of the respective authorities in the USA, the EU and Japan, and the systems were categorized through qualitative analysis. The pathways and programmes from each region were categorized into four groups, based on the requirement of pre- or post-marketing clinical data. Expedited-approval pathways in the USA and the EU provide similar qualification criteria, such as severity of target disease; however, such criteria are not specified for the new pathway in Japan. Only the Japanese pathway stipulates a time limitation on exceptional approval, requiring post-marketing study for conditional and time-limited products. Continuous improvement is necessary to solve previously addressed issues within the expedited-approval pathways and programmes and to ensure that innovative medical products are rigourously screened, but also readily available to patients in need. The time limitation of conditional approval could be a potential solution to some of these problems. Copyright © 2017 The Authors. Tissue Engineering Regenerative Medicine published by John Wiley & Sons, Ltd. Copyright © 2017 The Authors. Tissue

Withdrawal of cerivastatin from the world market

Directory of Open Access Journals (Sweden)

Pitt Bertram

2001-09-01

Full Text Available Abstract Cerivastatin was recently withdrawn from the market because of 52 deaths attributed to drug-related rhabdomyolysis that lead to kidney failure. The risk was found to be higher among patients who received the full dose (0.8 mg/day and those who received gemfibrozil concomitantly. Rhabdomyolysis was 10 times more common with cerivastatin than the other five approved statins. We address three important questions raised by this withdrawal. Should we continue to approve drugs on surrogate efficacy? Are all statins interchangeable? Do the benefits outweigh the risks of statins? We conclude that decisions regarding the use of drugs should be based on direct evidence from long-term clinical outcome trials.

A Concept of Location-Based Social Network Marketing

DEFF Research Database (Denmark)

Tussyadiah, Iis

2012-01-01

A stimulus-response model of location-based social network marketing is conceptualized based on an exploratory investigation. Location-based social network applications are capable of generating marketing stimuli from merchant, competition-based, and connection-based rewards resulted from relevance...... and connectivity. Depending on consumption situations, consumer characteristics, and social network structure, these rewards lead to actual behavior that manifests in variety behavior (i.e., patronage to new places) and loyalty behavior (i.e., increased frequency of patronage to familiar places). This behavior...... implies changes in patterns of mobility, making this marketing approach particularly relevant for tourism and hospitality businesses. Managerial implications and recommendations for further studies are provided....

Virtual Community Based Destination Marketing with YouTube

DEFF Research Database (Denmark)

Sambhanthan, Arunasalam; Thelijjagoda, Samantha; Good, Alice

2016-01-01

YouTube has now evolved into a powerful medium for social interaction. Utilizing YouTube for enhancing marketing endeavours is a strategy practiced by marketing professionals across several industries. This paper rationalizes on the different strategies of leveraging YouTube-based platforms...... for effective destination marketing by the hospitality industry (hotels) and provides insights on the critical drivers and challenges embedded within YouTube-based community interactions for destination marketing. The comments made by YouTube users have been subjected to a content analysis and the results...... are reported under the five broad clusters of virtual communities. More broadly, the typology of virtual communities is adapted to evaluate the YouTube platform for effective destination marketing....

Market based solutions for power pricing

International Nuclear Information System (INIS)

Wangensteen, Ivar

2002-06-01

The report examines how the price for effect reserves, spot market power and regulated power is formed provided ideal market conditions rule. Primarily the price determining factors in a market for power reserves are examined and how the connection between this market and the energy market (the spot market) is. In a free market there would be a balance between what the actors may obtain by operating in the open market for power reserves/regulated power on the one hand and the market for spot power on the other. Primarily we suppose that the desired amount of power reserve is known. Secondly the problem constellation is extended to comprise the size of the effect reserves i.e. the optimising of the requirement to the power reserves. The optimal amount of power reserves is obtained when there is a balance between the cost and the benefit. This optimal balance is achieved when expected macro economical loss due to outfacing balances against the cost of maintaining larger reserves. By using a simple model it is demonstrated that a system operator regulates the maximal price in the regulated market and this equals the rationing price. The actors will offer sufficient reserves even if the reserve price is zero (provided risk neutrality). If the maximal price for regulated power is lower the price of effect reserves will rise. Based on the same simple model calculations are made for how short and long term market balance will be for increasing demands

78 FR 38912 - Notice of Request for Revision of a Currently Approved Information Collection

Science.gov (United States)

2013-06-28

... immediate production and marketing decisions and as a guide to the amount of product in the supply channel... DEPARTMENT OF AGRICULTURE Agricultural Marketing Service [Document No. AMS-FV-13-0022] Notice of Request for Revision of a Currently Approved Information Collection AGENCY: Agricultural Marketing Service...

Bringing plant-based veterinary vaccines to market: Managing regulatory and commercial hurdles.

Science.gov (United States)

MacDonald, Jacqueline; Doshi, Ketan; Dussault, Marike; Hall, J Christopher; Holbrook, Larry; Jones, Ginny; Kaldis, Angelo; Klima, Cassidy L; Macdonald, Phil; McAllister, Tim; McLean, Michael D; Potter, Andrew; Richman, Alex; Shearer, Heather; Yarosh, Oksana; Yoo, Han Sang; Topp, Edward; Menassa, Rima

2015-12-01

The production of recombinant vaccines in plants may help to reduce the burden of veterinary diseases, which cause major economic losses and in some cases can affect human health. While there is abundant research in this area, a knowledge gap exists between the ability to create and evaluate plant-based products in the laboratory, and the ability to take these products on a path to commercialization. The current report, arising from a workshop sponsored by an Organisation for Economic Co-operation and Development (OECD) Co-operative Research Programme, addresses this gap by providing guidance in planning for the commercialization of plant-made vaccines for animal use. It includes relevant information on developing business plans, assessing market opportunities, manufacturing scale-up, financing, protecting and using intellectual property, and regulatory approval with a focus on Canadian regulations. Crown Copyright © 2015. Published by Elsevier Inc. All rights reserved.

A Market-Based Virtual Power Plant

DEFF Research Database (Denmark)

You, Shi; Træholt, Chresten; Poulsen, Bjarne

2009-01-01

The fast growing penetration of Distributed Energy Resources (DER) and the continuing trend towards a more liberalized electricity market requires more efficient energy management strategies to handle both emerging technical and economic issues. In this paper, a market-based Virtual Power Plant...... (MBVPP) model is proposed which provides individual DER units the accesses to current electricity markets. General bidding scenario and price signal scenario as two optional operation scenarios are operated by one MBVPP. In the end, a use case of a MBVPP with micro Combined Heat and Power (μCHP) systems...

78 FR 23883 - Marketing Orders for Fruit Crops; Notice of Request for Extension and Revision of a Currently...

Science.gov (United States)

2013-04-23

... Extension and Revision of a Currently Approved Information Collection AGENCY: Agricultural Marketing Service... submitted through the Internet at http://www.regulations.gov . SUPPLEMENTARY INFORMATION: Title: Marketing... Request: Extension and Revision of a currently approved information collection. Abstract: Marketing orders...

Regulating deregulated energy markets

International Nuclear Information System (INIS)

Jackson, M.

2002-01-01

The North American gas and electricity markets are fast evolving, and regulators are currently faced with a host of issues such as market-based rates, unbundling, stranded costs, open access, and incentive regulation are surfacing as a result of deregulation. The regulatory environment in Ontario was reviewed by the author. Deregulated markets rule, from commodities to gas and electricity. Additionally, there is an evolution of traditional utility regulation. A look at deregulated markets revealed that there are regulations on boundary conditions on the deregulated market. Under the Ontario Energy Board (OEB), all generators, transmitters, distributors, and retailers of electricity must be licensed. The standard supply service (SSS) offered by electricity distributors and system gas which is still being sold by natural gas distributors continues to be regulated by OEB. One issue that was addressed was separation for revenues and costs of the utility's purchase and sale of gas business, at least for accounting purposes. The next issue discussed was cost of system gas and SSS, followed by timely signals and prudent incurred costs. Historical benefits were reviewed, such as historical commitments to low-cost electricity. Pooling transportation costs, transmission pricing continued, market-based rates, unbundling, stranded costs, open access, incentive regulation/ performance based regulation (PBR) were all discussed. Price cap on PBR, both partial and comprehensive were looked at. A requirement to review guidelines on cost of capital and an application to extend blanket approval provisions for gas storage were discussed, as they are amongst some of the challenges of the future. Other challenges include revised rules and practice and procedure; practice directions for cost awards, appeals, and other functions; confidentiality guidelines; and refinements to the role of and approaches to alternative dispute resolution. The future role of regulators was examined in light

Advancement of Marketing Developing Biotechnology-Based Business

OpenAIRE

Vilmantas, Vaidas; Melnikas, Borisas

2014-01-01

The article, in a complex way, analyzes the needs of marketing improvement in developing biotechnology-based business and highlights its role in the context of modern society and globalization challenges. The article distinguishes between the existing problems of biotechnology business, the present perspectives and specific characteristics of developing the marketing of biotechnological business. The paper represents the possibility of the substantial modernization of marketing tools with reg...

7 CFR 3565.353 - Affirmative fair housing marketing.

Science.gov (United States)

2010-01-01

... 7 Agriculture 15 2010-01-01 2010-01-01 false Affirmative fair housing marketing. 3565.353 Section... fair housing marketing. As a condition of the guarantee, the lender must ensure that the lender and borrower are in compliance with the approved Affirmative Fair Housing Marketing Plan. This plan must be...

Studies in market-based electric power trade and regulation

International Nuclear Information System (INIS)

Hope, Einar

2000-01-01

This is a compilation of articles written by the author during the last fifteen years. Most of the articles are related to the reform of the Norwegian electric power market. This reform led to the Energy Act of 1990 and to the subsequent development of the power markets. Some of the sections are in Norwegian, some in English. The sections discuss (1) Markets for electricity trade in Norway, (2) Economic incentives and public firm behaviour, (3) Market alternatives to the present forms of occasional power trade, (4) Socio-economic considerations about electricity pricing, (5) Scenarios for market based power trade in Norway, (6) Markets for electricity: economic reform of the Norwegian electricity industry, (7) The Norwegian power market, (8) A common Nordic energy market?, (9) Organization of supply markets for natural gas in Europe, (10) The extent of the central grid, (11) Optimum regulation of grid monopolies in the power trade, (12) Power markets and competition policy, (13) Deregulation of the Norwegian power sector, (14) designing a market based system for the Icelandic electricity industry and (15) regulation regimes for the power sector

7 CFR 1467.20 - Market-based conservation initiatives.

Science.gov (United States)

2010-01-01

... 7 Agriculture 10 2010-01-01 2010-01-01 false Market-based conservation initiatives. 1467.20....20 Market-based conservation initiatives. (a) Acceptance and use of contributions. Section 1241(e) of... for Conservation Improvements. (1) USDA recognizes that environmental benefits will be achieved by...

Post-market clinical research conducted by medical device manufacturers: a cross-sectional survey.

Science.gov (United States)

Ross, Joseph S; Blount, Katrina L; Ritchie, Jessica D; Hodshon, Beth; Krumholz, Harlan M

2015-01-01

In the US, once a medical device is made available for use, several requirements have been established by the US Food and Drug Administration (FDA) to ensure ongoing post-market surveillance of device safety and effectiveness. Our objective was to determine how commonly medical device manufacturers initiate post-market clinical studies or augment FDA post-market surveillance requirements for higher-risk devices that are most often approved via the FDA's pre-market approval (PMA) pathway. We conducted a cross-sectional survey of 47 manufacturers with operations in California, Minnesota, and Massachusetts who market devices approved via the PMA pathway. Among 22 respondents (response rate =47%), nearly all self-reported conducting post-market clinical research studies, commonly between 1 and 5; only 1 respondent reported never conducting post-market clinical research studies. While manufacturers most often engaged in these studies to satisfy FDA requirements, other reasons were reported, including performance monitoring and surveillance and market acceptance initiatives. Risks of conducting and not conducting post-market clinical research studies were described through open-ended response to questions. Medical device manufacturers commonly initiate post-market clinical studies at the request of the FDA. Clinical data from these studies should be integrated into national post-market surveillance initiatives.

Bidding strategy in pay-as-bid markets based on supplier-market interaction analysis

International Nuclear Information System (INIS)

Bigdeli, N.; Afshar, K.; Fotuhi-Firuzabad, M.

2010-01-01

In this paper, a new bidding strategy for pay-as-bid market suppliers is introduced. This method is based on a systematic analysis of interactions of market with the suppliers via several market indices as well as forecasting important indices by artificial neural networks. Besides, the proposed method considers the practical limitations in the system and deals with incomplete information handling, closely. Next, a strategic bidding approach is proposed for optimal bidding by the suppliers. In these investigations, the paper focus is on the experimental situation of Iran electricity market as a pay-as-bid market and a sample generating company with several generating units from this market is considered as the benchmark. The results of applying this approach to this generating company are representative of good performance of the proposed method.

Flow-based market coupling. Stepping stone towards nodal pricing?

International Nuclear Information System (INIS)

Van der Welle, A.J.

2012-07-01

For achieving one internal energy market for electricity by 2014, market coupling is deployed to integrate national markets into regional markets and ultimately one European electricity market. The extent to which markets can be coupled depends on the available transmission capacities between countries. Since interconnections are congested from time to time, congestion management methods are deployed to divide the scarce available transmission capacities over market participants. For further optimization of the use of available transmission capacities while maintaining current security of supply levels, flow-based market coupling (FBMC) will be implemented in the CWE region by 2013. Although this is an important step forward, important hurdles for efficient congestion management remain. Hence, flow based market coupling is compared to nodal pricing, which is often considered as the most optimal solution from theoretical perspective. In the context of decarbonised power systems it is concluded that advantages of nodal pricing are likely to exceed its disadvantages, warranting further development of FBMC in the direction of nodal pricing.

7 CFR 930.48 - Research, market development and promotion.

Science.gov (United States)

2010-01-01

... 7 Agriculture 8 2010-01-01 2010-01-01 false Research, market development and promotion. 930.48... Order Regulating Handling Research, Market Development and Promotion § 930.48 Research, market development and promotion. The Board, with the approval of the Secretary, may establish or provide for the...

A comprehensive market-based scheme for VAR management and pricing in the electricity markets

Energy Technology Data Exchange (ETDEWEB)

El-Araby, E.E. [Qassim Univ., Alqassim, Meldia (Saudi Arabia). Dept. of Electrical Engineering

2009-07-01

In order to enable a power system to operate within an acceptable degree of reliability and security, the provision of VAR ancillary services from the VAR sources in electricity markets is the most effective method. The procurement of VAR services is particularly problematic for transmission operators as it relates to pricing mechanism and various technical issues during system operation. This paper proposed an integrated market-based approach for pricing VAR service in the electricity market. The paper was an extension of the authors' proposal for the provision of the VAR service from dynamic VAR sources in a competitive market-based environment. The formulation was modified to include VAR utilization payment and possible power system transition states multiple base cases and contingencies with their associated occurrence probabilities. The paper discussed the basic terms of the proposed approach including the VAR market objective and generator VAR output and its compensation. The mathematical formulation that considered VAR capacity payment, utilization payment and operating costs under the previous transition states in a unified single problem were introduced. The overall problem formulation and solution algorithm were also presented as a large-scale mixed integer nonlinear optimization problem. It was concluded that the proposed method was suited for the simulation and analysis of the existing VAR market. 8 refs., 3 tabs., 5 figs., 2 appendices.

77 FR 60085 - Approval and Promulgation of Air Quality Implementation Plans; West Virginia; The 2002 Base Year...

Science.gov (United States)

2012-10-02

... Promulgation of Air Quality Implementation Plans; West Virginia; The 2002 Base Year Inventory for the... proposing to approve the fine particulate matter (PM 2.5 ) 2002 base year emissions inventory portion of the... Quality Standard (NAAQS) SIP. EPA is proposing to approve the 2002 base year PM 2.5 emissions inventory...

7 CFR 915.45 - Production research, marketing research and development.

Science.gov (United States)

2010-01-01

... 7 Agriculture 8 2010-01-01 2010-01-01 false Production research, marketing research and... Production research, marketing research and development. The committee may, with the approval of the Secretary, establish or provide for the establishment of production research, marketing research and...

77 FR 60094 - Approval and Promulgation of Air Quality Implementation Plans; West Virginia; The 2002 Base Year...

Science.gov (United States)

2012-10-02

... Promulgation of Air Quality Implementation Plans; West Virginia; The 2002 Base Year Inventory for the... proposing to approve the fine particulate matter (PM 2.5 ) 2002 base year emissions inventory portion of the... Standard (NAAQS) SIP. EPA is proposing to approve the 2002 base year PM 2.5 emissions inventory for the...

77 FR 60087 - Approval and Promulgation of Air Quality Implementation Plans; West Virginia; The 2002 Base Year...

Science.gov (United States)

2012-10-02

... Promulgation of Air Quality Implementation Plans; West Virginia; The 2002 Base Year Inventory for the... proposing to approve the fine particulate matter (PM 2.5 ) 2002 base year emissions inventory portion of the... National Ambient Air Quality Standard (NAAQS) SIP. EPA is proposing to approve the 2002 base year PM 2.5...

Markets for Canadian bitumen-based feedstock

International Nuclear Information System (INIS)

Marshall, R.; Lauerman, V.; Yamaguchi, N.

2001-02-01

This study was undertaken in an effort to determine the market potential for crude bitumen and derivative products from the Western Canadian Sedimentary Basin in 2007. As part of the study, CERI assessed the economic viability of a wide range of bitumen-based feedstock based on their refining values, investigated the sensitivity of refinery demand to the prices of these feedstocks, and examined the competitiveness of bitumen-based feedstocks and conventional crudes. A US$18.00 per barrel price for West Texas Intermediate at Cushing, Oklahoma, was assumed in all calculations, including other crude prices, as well as for Western Canadian and US crude oil production forecasts. Four different scenarios have been considered, but only the 'most plausible' scenario is discussed in the report. Consequently, Hydrocracked/Aromatics Saturated Synthetic Crude Oil, which is currently only a hypothetical product, is excluded from consideration. The availability of historical price differentials for the various competing crudes was another assumption used in developing the scenario. Proxy prices for the bitumen-based feedstock were based on their respective supply costs. The study concludes that the principal dilemma facing bitumen producers in Western Canada is to determine the amount of upgrading necessary to ensure an economic market for their product in the future. In general, the greater the degree of upgrading, the higher is the demand for bitumen-based feedstock. However, it must be kept in mind that the upgrading decisions of other bitumen producers, along with many other factors, will have a decisive impact on the economics of any individual project. The combination of coking capacity and asphalt demand limits the market for heavy and extra-heavy crudes. As a result, the researchers concluded that major expansion of heavy crude conversion capacity may have to wait until the end of the current decade. The economic market for bitumen-based blends in 2007 is estimated at

Foundations of Constructing a Marketing Data Base; Profitable Applications of the Computer to Marketing Management.

Science.gov (United States)

Podell, Harold J.

An introduction into the foundations of constructing a marketing data base is presented for the systems and marketing executives who are familiar with basic computer technology methods. The techniques and concepts presented are now being implemented by major organizations in the development of Management Information Systems (MIS). A marketing data…

A market-based optimization approach to sensor and resource management

Science.gov (United States)

Schrage, Dan; Farnham, Christopher; Gonsalves, Paul G.

2006-05-01

Dynamic resource allocation for sensor management is a problem that demands solutions beyond traditional approaches to optimization. Market-based optimization applies solutions from economic theory, particularly game theory, to the resource allocation problem by creating an artificial market for sensor information and computational resources. Intelligent agents are the buyers and sellers in this market, and they represent all the elements of the sensor network, from sensors to sensor platforms to computational resources. These agents interact based on a negotiation mechanism that determines their bidding strategies. This negotiation mechanism and the agents' bidding strategies are based on game theory, and they are designed so that the aggregate result of the multi-agent negotiation process is a market in competitive equilibrium, which guarantees an optimal allocation of resources throughout the sensor network. This paper makes two contributions to the field of market-based optimization: First, we develop a market protocol to handle heterogeneous goods in a dynamic setting. Second, we develop arbitrage agents to improve the efficiency in the market in light of its dynamic nature.

A Market-Based Approach to Multi-factory Scheduling

Science.gov (United States)

Vytelingum, Perukrishnen; Rogers, Alex; MacBeth, Douglas K.; Dutta, Partha; Stranjak, Armin; Jennings, Nicholas R.

In this paper, we report on the design of a novel market-based approach for decentralised scheduling across multiple factories. Specifically, because of the limitations of scheduling in a centralised manner - which requires a center to have complete and perfect information for optimality and the truthful revelation of potentially commercially private preferences to that center - we advocate an informationally decentralised approach that is both agile and dynamic. In particular, this work adopts a market-based approach for decentralised scheduling by considering the different stakeholders representing different factories as self-interested, profit-motivated economic agents that trade resources for the scheduling of jobs. The overall schedule of these jobs is then an emergent behaviour of the strategic interaction of these trading agents bidding for resources in a market based on limited information and their own preferences. Using a simple (zero-intelligence) bidding strategy, we empirically demonstrate that our market-based approach achieves a lower bound efficiency of 84%. This represents a trade-off between a reasonable level of efficiency (compared to a centralised approach) and the desirable benefits of a decentralised solution.

A Knowledge-Based Consultant for Financial Marketing

OpenAIRE

Kastner, John; Apte, Chidanand; Griesmer, James

1986-01-01

This article describes an effort to develop a knowledge-based financial marketing consultant system. Financial marketing is an excellent vehicle for both research and application in artificial intelligence (AI). This domain differs from the great majority of previous expert system domains in that there are no well-defined answers (in traditional sense); the goal here is to obtain satisfactory arguments to support the conclusions made. A large OPS5-based system was implemented as an initial pr...

Structural changes in the German pharmaceutical market: price setting mechanisms based on the early benefit evaluation.

Science.gov (United States)

Henschke, Cornelia; Sundmacher, Leonie; Busse, Reinhard

2013-03-01

In the past, free price setting mechanisms in Germany led to high prices of patented pharmaceuticals and to increasing expenditures in the pharmaceutical sector. In order to control patented pharmaceutical prices and to curb increasing pharmaceutical spending, the Act for Restructuring the Pharmaceutical Market in Statutory Health Insurance (AMNOG) came into effect on 1st January 2011. In a structured dossier, pharmaceutical manufacturers have to demonstrate the additional therapeutic benefit of the newly approved pharmaceutical compared to its appropriate comparator. According to the level of additional benefit, pharmaceuticals will be subject to price negotiations between the Federal Association of Statutory Health Insurance Funds and the pharmaceutical company concerned (or assigned to a reference price group in case of no additional benefit). Therefore, the health care reform is a first step to decision making based on "value for money". The process of price setting based on early benefit evaluation has an impact on the German as well as the European pharmaceutical markets. Therefore, these structural changes in Germany are of importance for pricing decisions in many European countries both from a political point of view and for strategic planning for pharmaceutical manufacturers, which may have an effect on insured patients' access to pharmaceuticals. Copyright © 2012 Elsevier Ireland Ltd. All rights reserved.

Markets for Canadian bitumen-based feedstock

International Nuclear Information System (INIS)

Lauerman, V.

2001-01-01

The best types of refineries for processing western Canadian bitumen-based feedstock (BBF) were identified and a potential market for these feedstock for year 2007 was calculated. In addition, this power point presentation provided an estimation of potential regional and total demand for BBF. BBF included Athabasca bitumen blend, de-asphalted blend, coked sour crude oil (SCO), coked sweet SCO, hydrocracked SCO and hydrocracked/aromatic saturated SCO (HAS). Refinery prototypes included light and mixed prototypes for primary cracking units, light and heavy prototypes for primary coking units, as well as no coking, coking severe and residuum prototypes for primary hydrocracking units. The presentation included graphs depicting the natural market for Western Canadian crudes as well as U.S. crude oil production forecasts by PADD districts. It was forecasted that the market for bitumen-based feedstock in 2007 will be tight and that the potential demand for bitumen-based blends would be similar to expected production. It was also forecasted that the potential demand for SCO is not as promising relative to the expected production, unless price discounting or HAS will be available. 11 figs

[Marketing approval and market surveillance of medical devices in Germany: Where does policy integration take place?].

Science.gov (United States)

Lang, Achim

2014-01-01

Since 2011 new regulatory measures regarding medical devices have been set up with the aim to eliminate obstacles to innovations and to find more coordinated ways to marketing authorisation and market surveillance. This essay investigates whether these new and existing coordination mechanisms build up to a Joined-up Government approach. The analysis shows that the regulatory process should be adjusted along several dimensions. First, many organisations lack awareness regarding their stakeholders and focus solely on their immediate organisational activities. Second, the regulatory process (marketing authorisation and market surveillance) is too fragmented for an effective communication to take place. Finally, the underlying strategy process is an ad-hoc approach lacking continuity and continued involvement of, in particular, the responsible federal ministries. Copyright © 2013. Published by Elsevier GmbH.

Vertical integration and market power: A model-based analysis of restructuring in the Korean electricity market

International Nuclear Information System (INIS)

Bunn, Derek W.; Martoccia, Maria; Ochoa, Patricia; Kim, Haein; Ahn, Nam-Sung; Yoon, Yong-Beom

2010-01-01

An agent-based simulation model is developed using computational learning to investigate the impact of vertical integration between electricity generators and retailers on market power in a competitive wholesale market setting. It is observed that if partial vertical integration creates some market foreclosure, whether this leads to an increase or decrease in market power is situation specific. A detailed application to the Korean market structure reveals this to be the case. We find that in various cases, whilst vertical integration generally reduces spot prices, it can increase or decrease the market power of other market generators, depending upon the market share and the technology segment of the market, which is integrated, as well as the market concentrations before and after the integration.

Vertical integration and market power. A model-based analysis of restructuring in the Korean electricity market

Energy Technology Data Exchange (ETDEWEB)

Bunn, Derek W.; Martoccia, Maria; Ochoa, Patricia [London Business School, London (United Kingdom); Kim, Haein; Ahn, Nam-Sung; Yoon, Yong-Beom [Korean Electric Power Corporation, Seoul (Korea)

2010-07-15

An agent-based simulation model is developed using computational learning to investigate the impact of vertical integration between electricity generators and retailers on market power in a competitive wholesale market setting. It is observed that if partial vertical integration creates some market foreclosure, whether this leads to an increase or decrease in market power is situation specific. A detailed application to the Korean market structure reveals this to be the case. We find that in various cases, whilst vertical integration generally reduces spot prices, it can increase or decrease the market power of other market generators, depending upon the market share and the technology segment of the market, which is integrated, as well as the market concentrations before and after the integration. (author)

Vertical integration and market power: A model-based analysis of restructuring in the Korean electricity market

Energy Technology Data Exchange (ETDEWEB)

Bunn, Derek W., E-mail: dbunn@london.ed [London Business School, London (United Kingdom); Martoccia, Maria; Ochoa, Patricia [London Business School, London (United Kingdom); Kim, Haein; Ahn, Nam-Sung; Yoon, Yong-Beom [Korean Electric Power Corporation, Seoul (Korea, Republic of)

2010-07-15

An agent-based simulation model is developed using computational learning to investigate the impact of vertical integration between electricity generators and retailers on market power in a competitive wholesale market setting. It is observed that if partial vertical integration creates some market foreclosure, whether this leads to an increase or decrease in market power is situation specific. A detailed application to the Korean market structure reveals this to be the case. We find that in various cases, whilst vertical integration generally reduces spot prices, it can increase or decrease the market power of other market generators, depending upon the market share and the technology segment of the market, which is integrated, as well as the market concentrations before and after the integration.

Challenges in the development of market-based pipeline investments

International Nuclear Information System (INIS)

Von Bassenheim, G.; Mohitpour, M.; Klaudt, D.; Jenkins, A.

2000-01-01

The challenges, risks and uncertainties that the natural gas industry faces in developing market-based pipeline projects were discussed. Market-based pipeline investments are fundamentally different from user-driven projects. Market-based projected involve finding enough energy users and linking them with a pipeline infrastructure to viable supplies of natural gas. Each unique project is developed individually and requires a strong corporate vision and support before it can be successfully implemented. The three phases of a pipeline investment include the business development phase, the project development phase, and the implementation/operations phase. Market-based companies will need a clear vision for long-term goals and the desire to succeed. The company will have to prepare a detailed strategy and policies that clearly define geographic areas of operations, risk tolerance, availability of capital and expected project performance. 3 refs., 3 tabs., 2 figs

75 FR 36059 - Notice of Request for Extension and Revision of a Currently Approved Information Collection

Science.gov (United States)

2010-06-24

... Internet at http://www.regulations.gov . SUPPLEMENTARY INFORMATION: Title: Marketing Orders for Fruit Crops... Revision of a currently approved information collection. Abstract: Marketing order programs provide an... DEPARTMENT OF AGRICULTURE Agricultural Marketing Service [Doc. No. AMS-FV-10-0033; FV10-902-1NC...

75 FR 5940 - Notice of Request for Extension and Revision of a Currently Approved Information Collection

Science.gov (United States)

2010-02-05

... Approved Information Collection AGENCY: Agricultural Marketing Service, USDA. ACTION: Notice and request... information collection, Federal-State Marketing Improvement Program (FSMIP). DATES: Comments on this notice... INFORMATION: FSMIP is authorized under Section 204(b) of the Agricultural Marketing Act of 1946 (7 U.S.C. 1621...

76 FR 66682 - Request for an Extension to a Currently Approved Information Collection for the Regulations...

Science.gov (United States)

2011-10-27

... Marketing Service's (AMS) intention to request approval from the Office of Management and Budget, for an... DEPARTMENT OF AGRICULTURE Agricultural Marketing Service [Doc. No.: AMS-DA-11-0087; DA-11-05] RIN...) AGENCY: Agricultural Marketing Service, USDA. ACTION: Request for comments. SUMMARY: In accordance with...

Post-market clinical research conducted by medical device manufacturers: a cross-sectional survey

Directory of Open Access Journals (Sweden)

Ross JS

2015-05-01

Full Text Available Joseph S Ross, Katrina L Blount, Jessica D Ritchie, Beth Hodshon, Harlan M Krumholz Center for Outcomes Research and Evaluation, Yale-New Haven Hospital, New Haven, CT, USA Background: In the US, once a medical device is made available for use, several requirements have been established by the US Food and Drug Administration (FDA to ensure ongoing post-market surveillance of device safety and effectiveness. Our objective was to determine how commonly medical device manufacturers initiate post-market clinical studies or augment FDA post-market surveillance requirements for higher-risk devices that are most often approved via the FDA's pre-market approval (PMA pathway. Methods and results: We conducted a cross-sectional survey of 47 manufacturers with operations in California, Minnesota, and Massachusetts who market devices approved via the PMA pathway. Among 22 respondents (response rate =47%, nearly all self-reported conducting post-market clinical research studies, commonly between 1 and 5; only 1 respondent reported never conducting post-market clinical research studies. While manufacturers most often engaged in these studies to satisfy FDA requirements, other reasons were reported, including performance monitoring and surveillance and market acceptance initiatives. Risks of conducting and not conducting post-market clinical research studies were described through open-ended response to questions. Conclusion: Medical device manufacturers commonly initiate post-market clinical studies at the request of the FDA. Clinical data from these studies should be integrated into national post-market surveillance initiatives. Keywords: FDA, PMA pathway, post-market surveillance

Avelumab: First Global Approval.

Science.gov (United States)

Kim, Esther S

2017-05-01

Avelumab (Bavencio ® ) is an intravenously administered programmed cell death ligand-1-blocking human antibody initially developed by EMD Serono Inc. (the biopharmaceutical division of Merck KGaA, Darmstadt, Germany) [now jointly developed and commercialized by EMD Serono Inc. and Pfizer] for the treatment of various tumours. It has received accelerated approval in the USA for the treatment of metastatic Merkel cell carcinoma (mMCC) in adults and paediatric patients aged ≥12 years. The marketing authorization application for avelumab in the treatment of mMCC is undergoing regulatory review in the EU, the biologics license application for avelumab in the treatment of urothelial carcinoma is undergoing priority review by the FDA, and avelumab is in various stages of development internationally for a variety of cancers. This article summarizes the milestones in the development of avelumab leading to this first approval for mMCC.

A Risk Metric Assessment of Scenario-Based Market Risk Measures for Volatility and Risk Estimation: Evidence from Emerging Markets

Directory of Open Access Journals (Sweden)

Sitima Innocent

2015-03-01

Full Text Available The study evaluated the sensitivity of the Value- at- Risk (VaR and Expected Shortfalls (ES with respect to portfolio allocation in emerging markets with an index portfolio of a developed market. This study utilised different models for VaR and ES techniques using various scenario-based models such as Covariance Methods, Historical Simulation and the GARCH (1, 1 for the predictive ability of these models in both relatively stable market conditions and extreme market conditions. The results showed that Expected Shortfall has less risk tolerance than VaR based on the same scenario-based market risk measures

Exploring policy impacts for servicising in product-based markets : A generic agent-based model

NARCIS (Netherlands)

van der Veen, R.A.C.; Kisjes, K.H.; Nikolic, I.

2017-01-01

The shift to markets based on servicising, i.e. market-level transitions from product-based to service-based production and consumption patterns, may contribute to achieve absolute decoupling, i.e. the combined development of economic growth and environmental impact reduction. However, the

NETWORK BASED BUSINESS MODEL INNOVATION TARGETING THE BOP MARKET

DEFF Research Database (Denmark)

Ravn, Jacob; Kroghstrup Nielsen, Martin; Lindgren, Peter

2009-01-01

Through innovation of products, process and business models targeting the needs of 4 billion poor people living at "the base of pyramid" (BoP) (Prahalad & Hart 2002) in developing countries the private sector can actively support poverty alleviation and at the same time reach new untouched market....... - A market is estimated a value of 5.3 trillion US$ (Hammond, Kramer, Tran, Kratz 2007). A number of researchers has dealt with the BoP - market potential and not least tried to understand how to penetrate this apparent blue ocean. Two distinct lines of thought when targeting BoP markets in developing...... & Halme 2008). The market and customer line - exemplified by soap producers trying to penetrate the BoPline - exemplified by soap producers trying to penetrate the BoP market through product adaptation selling soap in smaller packages (Hart & Christensen 2002, Prahalad 2006). Based on the case study...

An Agent-Based Computational Model for China’s Stock Market and Stock Index Futures Market

Directory of Open Access Journals (Sweden)

Hai-Chuan Xu

2014-01-01

Full Text Available This study presents an agent-based computational cross market model for Chinese equity market structure, which includes both stocks and CSI 300 index futures. In this model, we design several stocks and one index future to simulate this structure. This model allows heterogeneous investors to make investment decisions with restrictions including wealth, market trading mechanism, and risk management. Investors’ demands and order submissions are endogenously determined. Our model successfully reproduces several key features of the Chinese financial markets including spot-futures basis distribution, bid-ask spread distribution, volatility clustering, and long memory in absolute returns. Our model can be applied in cross market risk control, market mechanism design, and arbitrage strategies analysis.

75 FR 44934 - Notice of Request for Extension and Revision of a Currently Approved Information Collection

Science.gov (United States)

2010-07-30

... Approved Information Collection AGENCY: Agricultural Marketing Service, USDA. ACTION: Notice and request... information collection. Abstract: Federal milk marketing order regulations authorized under the Agricultural... / Friday, July 30, 2010 / Notices#0;#0; [[Page 44934

Bringing smart pills to market: FDA regulation of ingestible drug/device combination products.

Science.gov (United States)

Avery, Matthew; Liu, Dan

2011-01-01

Imagine a pill that, after you swallow it, can track its position in your body. Or imagine a pill that can transmit a message to a doctor to tell him that you have taken your bitter medicine. Pills like this already exist. These so-called smart pills are an emerging type of medical therapy. However, this nascent technology has yet to reach the market and developers of these novel therapies face significant regulatory challenges. This article predicts how the Food and Drug Administration will regulate smart pills and shows how the current regulatory regime is inadequate. The article then proposes modifying the current regulatory regime to encourage development of smart pills and other innovative combination products by: (1) regulating combination products based on their "novel mode of action" rather than their "primary mode of action," (2) creating a marketing approval pathway specifically for combination products, and (3) eliminating regulations that require sponsors to get marketing approval from multiple centers within FDA and providing regulatory guidance specifically for ingestible drug/device combination products.

48 CFR 245.7305 - Sale approval and award.

Science.gov (United States)

2010-10-01

... that the sale price is fair and reasonable, taking into consideration— (i) Knowledge or tests of the market; (ii) Current published prices for the property; (iii) The nature, condition, quantity, and...) Approve award to the responsible bidder whose bid is most advantageous to the Government, price and other...

Online marketing improvement based on marketing psychology, case: Roomsevilla

OpenAIRE

Laakkonen, Roosa

2013-01-01

The purpose of this thesis was to study and find out the best cost-effective online marketing channels for a Spanish housing agency Roomsevilla in order to strengthen its online marketing. In addition, this thesis aims to find out how the case company can use marketing psychology in its online marketing. The theoretical part includes online marketing, marketing mix and marketing psycho- logy which were collected from various books, online journals and websites. Also Cialdini's 6 Principle...

78 FR 17962 - Self-Regulatory Organizations; The NASDAQ Stock Market LLC; Notice of Filing and Immediate...

Science.gov (United States)

2013-03-25

... volatility. Economically Equivalent Products The Exchange has considered the existence of economically... accelerated rate, which the Exchange believes is a direct result of the implementation of the Delta-Based... limits thereon are eliminated. \\26\\ See SPXPM Approval at 55972. Market on Close Volatility The Exchange...

7 CFR 1717.608 - RUS approval of contracts.

Science.gov (United States)

2010-01-01

... the contracts or arrangements, and regardless of whether or not a Federal power marketing agency is a party to any of them. (d) System management and maintenance contracts. RUS approval of contracts for the management and operation of a borrower's electric system or for the maintenance of the electric system is...

Redefining trade-based market manipulation

NARCIS (Netherlands)

Nelemans, Matthijs

2008-01-01

Trade-based market manipulation, which is usually described as trading shares to initiate a price change or to cause an artificial price, has received wide attention in policy and academic discussions, although the behavior is still poorly defined in both legal and economic literature. This Article

Dynamic market behaviour of autonomous network based power systems

NARCIS (Netherlands)

Jokic, A.; Wittebol, E.H.M.; Bosch, van den P.P.J.

2006-01-01

Dynamic models of real-time markets are important since they lead to additional insights of the behavior and stability of power system markets. The main topic of this paper is the analysis of real-time market dynamics in a novel power system structure that is based on the concept of autonomous

A Novel Marketing Strategy based on Information Technology

Institute of Scientific and Technical Information of China (English)

Zhang Xiao

2012-01-01

Marketing, electronic data interchange, internet data center, electric ordering system Abstract：Marketing is the process of performing market research, selling products and/or services to customers and promoting them via advertising to further enhance sales. It generates the strategy that underlies sales techniques, business communication, and business developments. Information technology is the acquisition, processing, storage and dissemination of vocal, pictorial, textual and numerical information by a microelectronics-based combination of computing and telecommunications.

78 FR 23884 - Seed Testing Service Program; Request for an Extension of and Revision to a Currently Approved...

Science.gov (United States)

2013-04-23

... DEPARTMENT OF AGRICULTURE Agricultural Marketing Service [Doc. No. AMS-LS-13-0007] Seed Testing... AGENCY: Agricultural Marketing Service, USDA. ACTION: Request for comments. SUMMARY: In accordance with... Marketing Service's (AMS) intention to request approval from the Office of Management and Budget (OMB), for...

77 FR 32633 - Approval of Test Marketing Exemptions for Certain New Chemicals

Science.gov (United States)

2012-06-01

... of Customers: CBI. Test Marketing Period: CBI days, commencing on first day of commercial manufacture... inorganic pigments and extenders. Production Volume: CBI. Number of Customers: CBI. Test Marketing Period... Customers: CBI. Test Marketing Period: CBI days, commencing on first day of commercial manufacture. TME-11...

E-laboratories : agent-based modeling of electricity markets

International Nuclear Information System (INIS)

North, M.; Conzelmann, G.; Koritarov, V.; Macal, C.; Thimmapuram, P.; Veselka, T.

2002-01-01

Electricity markets are complex adaptive systems that operate under a wide range of rules that span a variety of time scales. These rules are imposed both from above by society and below by physics. Many electricity markets are undergoing or are about to undergo a transition from centrally regulated systems to decentralized markets. Furthermore, several electricity markets have recently undergone this transition with extremely unsatisfactory results, most notably in California. These high stakes transitions require the introduction of largely untested regulatory structures. Suitable laboratories that can be used to test regulatory structures before they are applied to real systems are needed. Agent-based models can provide such electronic laboratories or ''e-laboratories.'' To better understand the requirements of an electricity market e-laboratory, a live electricity market simulation was created. This experience helped to shape the development of the Electricity Market Complex Adaptive Systems (EMCAS) model. To explore EMCAS' potential as an e-laboratory, several variations of the live simulation were created. These variations probed the possible effects of changing power plant outages and price setting rules on electricity market prices

Forecasting the Electricity Demand and Market Shares in Retail Electricity Market Based on System Dynamics and Markov Chain

OpenAIRE

Qingyou Yan; Chao Qin; Mingjian Nie; Le Yang

2018-01-01

Due to the deregulation of retail electricity market, consumers can choose retail electric suppliers freely, and market entities are facing fierce competition because of the increasing number of new entrants. Under these circumstances, forecasting the changes in all market entities, when market share stabilized, is important for suppliers making marketing decisions. In this paper, a market share forecasting model was established based on Markov chain, and a system dynamics model was construct...

Agent-based simulation of electricity markets : a literature review

International Nuclear Information System (INIS)

Sensfuss, F.; Genoese, M.; Genoese, M.; Most, D.

2007-01-01

The electricity sector in Europe and North America is undergoing considerable changes as a result of deregulation, issues related to climate change, and the integration of renewable resources within the electricity grid. This article reviewed agent-based simulation methods of analyzing electricity markets. The paper provided an analysis of research currently being conducted on electricity market designs and examined methods of modelling agent decisions. Methods of coupling long term and short term decisions were also reviewed. Issues related to single and multiple market analysis methods were discussed, as well as different approaches to integrating agent-based models with models of other commodities. The integration of transmission constraints within agent-based models was also discussed, and methods of measuring market efficiency were evaluated. Other topics examined in the paper included approaches to integrating investment decisions, carbon dioxide (CO 2 ) trading, and renewable support schemes. It was concluded that agent-based models serve as a test bed for the electricity sector, and will help to provide insights for future policy decisions. 74 refs., 6 figs

Market-Based Resource Allocation in a Wirelessly Integrated Naval Engineering Plant

Science.gov (United States)

2009-12-01

available wireless nodes will be developed. Using a multi-agent approach based on free market economics (termed market based control) will be explored...as battery power, data storage capacity, MPU time, wireless bandwidth, etc.) required to perform complex computational tasks are available only in a...network. One approach to this problem is to apply free-market economics to help allocate these resources. Free-market economies can be thought of as

Pharmacovigilance of biologicals : dynamics in post-approval safety learning

NARCIS (Netherlands)

Vermeer, N.S.

2015-01-01

Regulatory decisions to allow new drugs on the market by definition have to accept a certain level of uncertainty about the full benefit-risk balance. Pre-approval studies typically provide information on a limited number of patients over a relative short follow-up period, and handle strict

75 FR 77634 - Approval of Test Marketing Exemptions for Certain New Chemicals

Science.gov (United States)

2010-12-13

.... Use: (G) Coatings resin. Production Volume: CBI. Number of Customers: CBI. Test Marketing Period: CBI.... Number of Customers: CBI. Test Marketing Period: CBI. TME-09-0012. Date of Receipt: May 29, 2009. Notice... binding resin. Production Volume: CBI. Number of Customers: CBI. Test Marketing Period: CBI. TME-10-0001...

Novel indexes based on network structure to indicate financial market

Science.gov (United States)

Zhong, Tao; Peng, Qinke; Wang, Xiao; Zhang, Jing

2016-02-01

There have been various achievements to understand and to analyze the financial market by complex network model. However, current studies analyze the financial network model but seldom present quantified indexes to indicate or forecast the price action of market. In this paper, the stock market is modeled as a dynamic network, in which the vertices refer to listed companies and edges refer to their rank-based correlation based on price series. Characteristics of the network are analyzed and then novel indexes are introduced into market analysis, which are calculated from maximum and fully-connected subnets. The indexes are compared with existing ones and the results confirm that our indexes perform better to indicate the daily trend of market composite index in advance. Via investment simulation, the performance of our indexes is analyzed in detail. The results indicate that the dynamic complex network model could not only serve as a structural description of the financial market, but also work to predict the market and guide investment by indexes.

A market-driven commercialization strategy for gasification-based technologies

International Nuclear Information System (INIS)

Klara, J.M.; Tomer, B.J.; Stiegel, G.J.

1998-01-01

In the wake of deregulation of power generation in the US, market-based competition is driving electricity generators to low-cost risk system. In such an environment, gasification-based technologies will not be competitive with low capital cost, efficient, and reliable natural gas-fired facilities for baseload power generation in the foreseeable future. The lack of a near-term market application poses a serious threat to the progress of gasification technology. With a reduction in direct federal funding of large-scale demonstration plants as the trend to reduce the size of government continues, an alternate approach to commercialize gasification-based technologies has been developed at DOE/FETC. This new strategy employs gasification in near-term markets where, due to its ability to coproduce a wide variety of commodity and premium products to meet market requirements, it is an attractive alternative. By obtaining operating experience in near-term coproduction applications, gasification system modules can be refined and improved leading to commercial guarantees and acceptance of gasification technology as a cost-effective technology for baseload power generation when this market begins to open domestically, sometime after 2005

Marketing for a Web-Based Master's Degree Program in Light of Marketing Mix Model

Science.gov (United States)

Pan, Cheng-Chang

2012-01-01

The marketing mix model was applied with a focus on Web media to re-strategize a Web-based Master's program in a southern state university in U.S. The program's existing marketing strategy was examined using the four components of the model: product, price, place, and promotion, in hopes to repackage the program (product) to prospective students…

Drivers of Adoption and Implementation of Internet-Based Marketing Channels

DEFF Research Database (Denmark)

Nielsen, Jørn Flohr; Mols, Niels Peter; Høst, Viggo

2007-01-01

This chapter analyses factors influencing manufacturers= adoption and implementation of Internet-based marketing channels, using models based on marketing channel and organisational innovation theory. Survey data from 1163 Danish, Finnish, and Swedish manufacturers form the empirical basis for te...

Mergers, acquisitions, divestitures, and applications for market-based rates in a deregulating electric utility industry

International Nuclear Information System (INIS)

Cox, A.J.

1999-01-01

In this article, the author reviews FERC's current procedures for undertaking competitive analysis. The current procedure for evaluating the competitive impact of transactions in the electric utility industry is described in Order 592, in particular Appendix A. These procedures effectively revised criteria that had been laid out in Commonwealth Edison and brought its merger policy in line with the EPAct and the provisions of Order 888. Order 592 was an attempt to provide more certainty and expedition in handling mergers. It established three criteria that had to be satisfied for a merger to be approved: Post-merger market power must be within acceptable thresholds or be satisfactorily mitigated, acceptable customer protections must be in place (to ensure that rates will not go up as a result of increased costs) and any adverse effect on regulation must be addressed. FERC states that its Order 592 Merger Policy Statement is based upon the Horizontal Merger Guidelines issued jointly by the Federal Trade Commission and the Antitrust Division Department of Justice (FTC/DOJ Merger Guidelines). While it borrows much of the language and basic concepts of the Merger Guidelines, FERC's procedures have been criticized as not following the methodology closely enough, leaving open the possibility of mistakes in market definition

Mergers, acquisitions, divestitures, and applications for market-based rates in a deregulating electric utility industry

Energy Technology Data Exchange (ETDEWEB)

Cox, A.J.

1999-05-01

In this article, the author reviews FERC's current procedures for undertaking competitive analysis. The current procedure for evaluating the competitive impact of transactions in the electric utility industry is described in Order 592, in particular Appendix A. These procedures effectively revised criteria that had been laid out in Commonwealth Edison and brought its merger policy in line with the EPAct and the provisions of Order 888. Order 592 was an attempt to provide more certainty and expedition in handling mergers. It established three criteria that had to be satisfied for a merger to be approved: Post-merger market power must be within acceptable thresholds or be satisfactorily mitigated, acceptable customer protections must be in place (to ensure that rates will not go up as a result of increased costs) and any adverse effect on regulation must be addressed. FERC states that its Order 592 Merger Policy Statement is based upon the Horizontal Merger Guidelines issued jointly by the Federal Trade Commission and the Antitrust Division Department of Justice (FTC/DOJ Merger Guidelines). While it borrows much of the language and basic concepts of the Merger Guidelines, FERC's procedures have been criticized as not following the methodology closely enough, leaving open the possibility of mistakes in market definition.

Supply Network Planning for New Product Market Entry in the Pharmaceutical Industry

DEFF Research Database (Denmark)

Hansen, Klaus Reinholdt Nyhuus; Grunow, Martin

2011-01-01

uncertainty and the risk of a forced label change and includes solution robustness. While considering limited shelf life of the drug, the supply of packaging material and outsourcing, the objective of our model is to reduce supply chain cost including lost peak sales from delayed market entry....... planning before and during the market entry of the drug after the drug has been approved. Production of the active pharmaceutical ingredient [API] is characterized by long change-over times due to cleaning requirements. Production planning is long term, multiple batches of each drug are produced...... industry, reimbursement negotiations have to be carried out before a drug can be marketed. These negotiations both necessitate time phasing market entries and introduce a series of uncertainties e.g. varying allowed price and awarded subsidy. Also if the label is not approved for marketing, all packaged...

Design and analysis of post-marketing research.

Science.gov (United States)

Zhou, Xiao-Hua Andrew; Yang, Wei

2013-07-01

A post-marketing study is an integral part of research that helps to ensure a favorable risk-benefit profile for approved drugs used in the market. Because most of post-marketing studies use observational designs, which are liable to confounding, estimation of the causal effect of a drug versus a comparative one is very challenging. This article focuses on methodological issues of importance in designing and analyzing studies to evaluate the safety of marketed drugs, especially marketed traditional Chinese medicine (TCM) products. Advantages and limitations of the current designs and analytic methods for postmarketing studies are discussed, and recommendations are given for improving the validity of postmarketing studies in TCM products.

A novel model for product bundling and direct marketing in e-commerce based on market segmentation

Directory of Open Access Journals (Sweden)

Arash Beheshtian-Ardakani

2018-01-01

Full Text Available Nowadays, companies offer product bundles with special discounts in order to sell more products. However, it is important to note that customers show different levels of loyalties to companies, and each segment of the market has unique features, which influences the customers’ buying patterns. The primary purpose of this paper is to propose a novel model for product bundling in e-commerce websites by using market segmentation variables and customer loyalty analysis. RFM model is employed to calculate customer loyalty. Subsequently, the customers are grouped based on their loyalty levels. Each group is then divided into different segments based on market segmentation variables. The product bundles are determined for each market segment via clustering algorithms. Apriori algorithm is also used to determine the association rules for each product bundle. Classification models are applied in order to determine which product bundle should be recommended to each customer. The results demonstrate that the silhouette coefficient, support, confidence, and accuracy values are higher when both customer loyalty level and market segmentation variables are used in product bundling. Accordingly, the proposed model increases the chance of success in direct marketing and recommending product bundles to customers.

Toward Value-Based Pricing to Boost Cancer Research and Innovation.

Science.gov (United States)

Ocana, Alberto; Amir, Eitan; Tannock, Ian F

2016-06-01

The high market price of new anticancer agents has stimulated debate about the long-term sustainability of healthcare systems and whether these new agents can continue to be supported by public healthcare or by private insurers. In addition, some drugs have been approved with limited clinical benefit, raising concerns about setting a minimum requirement for medical benefit. Options to resolve these problems include raising the bar for approval of new drugs and/or pricing of new agents based on the medical benefit that they offer to patients. In this commentary, we suggest that new agents should be marketed in a two-step process that would include first the approval of the new drug by the regulatory agencies and second the introduction of a market price based on the medical benefit that the new intervention offers to patients. Introduction of value-based pricing would maintain the sustainability of health care systems and would improve drug development, as it would pressure pharmaceutical companies to become more innovative and avoid the development of compounds with limited benefit. Value-based pricing could also stimulate the funding of research directed to development of new anticancer drugs with novel mechanisms of action. Cancer Res; 76(11); 3127-9. ©2016 AACR. ©2016 American Association for Cancer Research.

Biodiversity and Habitat Markets—Policy, Economic, and Ecological implications of Market-Based Conservation

Science.gov (United States)

Pindilli, Emily J.; Casey, Frank

2015-10-26

This report is a primer on market-like and market-based mechanisms designed to conserve biodiversity and habitat. The types of markets and market-based approaches that were implemented or are emerging to benefit biodiversity and habitat in the United States are examined. The central approaches considered in this report include payments for ecosystem services, conservation banks, habitat exchanges, and eco-labels. Based on literature reviews and input from experts and practitioners, the report characterizes each market-based approach including policy context and structure; the theoretical basis for applying market-based approaches; the ecological effectiveness of practices and tools for measuring performance; and the future outlook for biodiversity and habitat markets. This report draws from previous research and serves as a summary of pertinent information associated with biodiversity and habitat markets while providing references to materials that go into greater detail on specific topics.

Market-based demand forecasting promotes informed strategic financial planning.

Science.gov (United States)

Beech, A J

2001-11-01

Market-based demand forecasting is a method of estimating future demand for a healthcare organization's services by using a broad range of data that describe the nature of demand within the organization's service area. Such data include the primary and secondary service areas, the service-area populations by various demographic groupings, discharge utilization rates, market size, and market share by service line and organizationwide. Based on observable market dynamics, strategic planners can make a variety of explicit assumptions about future trends regarding these data to develop scenarios describing potential future demand. Financial planners then can evaluate each scenario to determine its potential effect on selected financial and operational measures, such as operating margin, days cash on hand, and debt-service coverage, and develop a strategic financial plan that covers a range of contingencies.

STOCK Market Differences in Correlation-Based Weighted Network

Science.gov (United States)

Youn, Janghyuk; Lee, Junghoon; Chang, Woojin

We examined the sector dynamics of Korean stock market in relation to the market volatility. The daily price data of 360 stocks for 5019 trading days (from January, 1990 to August, 2008) in Korean stock market are used. We performed the weighted network analysis and employed four measures: the average, the variance, the intensity, and the coherence of network weights (absolute values of stock return correlations) to investigate the network structure of Korean stock market. We performed regression analysis using the four measures in the seven major industry sectors and the market (seven sectors combined). We found that the average, the intensity, and the coherence of sector (subnetwork) weights increase as market becomes volatile. Except for the "Financials" sector, the variance of sector weights also grows as market volatility increases. Based on the four measures, we can categorize "Financials," "Information Technology" and "Industrials" sectors into one group, and "Materials" and "Consumer Discretionary" sectors into another group. We investigated the distributions of intrasector and intersector weights for each sector and found the differences in "Financials" sector are most distinct.

A study of real-time content marketing : formulating real-time content marketing based on content, search and social media

OpenAIRE

Nguyen, Thi Kim Duyen

2015-01-01

The primary objective of this research is to understand profoundly the new concept of content marketing – real-time content marketing on the aspect of the digital marketing experts. Particularly, the research will focus on the real-time content marketing theories and how to build real-time content marketing strategy based on content, search and social media. It also finds out how marketers measure and keep track of conversion rates of their real-time content marketing plan. Practically, th...

Longitudinal evaluation of a World Wide Web-based antimicrobial stewardship program: assessing factors associated with approval patterns and trends over time.

Science.gov (United States)

Venugopal, Vidya; Lehmann, Christoph U; Diener-West, Marie; Agwu, Allison L

2014-02-01

The Johns Hopkins Children's Medical and Surgery Center developed a Web-based Antimicrobial Stewardship Program (ASP) in 2005. The present study aimed to assess longitudinal antimicrobial request and approval patterns for this ASP. We analyzed a total of 16,229 antimicrobial requests for 3,542 patients between June 1, 2005, and June 30, 2009. Antimicrobial approval was the outcome of interest. We assessed gaming by studying trends in automatically approved requests. Nonparametric tests for trend were performed to detect changes in approval patterns. Multiple logistic regression was used to identify factors associated with approval. The vast majority (91.3%) of antimicrobial requests were approved, with an increase of 6.1% over time (P Web-based ASP allows management of a large number of antimicrobial requests, without apparent gaming. Observed differences in approval patterns based on patient, requestor, and antimicrobial factors may inform the development of ASPs and evaluation of provider education and training. Copyright © 2014 Association for Professionals in Infection Control and Epidemiology, Inc. Published by Mosby, Inc. All rights reserved.

Smart spatial incentives for market-based conservation

OpenAIRE

Hartig, Florian; Drechsler, Martin

2008-01-01

Market-based instruments such as payments, auctions or tradable permits have been proposed as flexible and cost-effective instruments for biodiversity conservation on private lands. Trading the service of conservation requires one to define a metric that determines the extent to which a conserved site adds to the regional conservation objective. Yet, while markets for conservation are widely discussed and increasingly applied, little research has been conducted on explicitly accounting for sp...

Overconfident investors in the LLS agent-based artificial financial market

NARCIS (Netherlands)

Lovric, M.; Kaymak, U.; Spronk, J.

2009-01-01

Agent-based artificial financial markets are bottom-up models of financial markets which explore the mapping from the micro level of individual investor behavior into the macro level of aggregate market phenomena. It has been recently recognized in the literature that such (agentbased) models are

Compliance of agrochemical marketers with banned cocoa pesticides in southwest Nigeria

OpenAIRE

Mokwunye Idongesit U.; Babalola Folaranmi D.; Asogwa Uche E.; Idris Ndagi; Aderolu Ismail A.; Mokwunye Francis C.; Idrisu Mohammed

2014-01-01

This study investigated the compliance of marketers of agrochemicals with the approved and banned cocoa pesticides in selected cocoa producing states of southwest Nigeria. Primary data was collected through the use of structured questionnaire administered to randomly selected agrochemical marketers. All the marketers (100%) were aware of the recently banned cocoa pesticides, however, majority still have the pesticides in stock. About 70.6% of the marketers ...

Real-time versus day-ahead market power in a hydro-based electricity market

OpenAIRE

Tangerås, Thomas P.; Mauritzen, Johannes

2014-01-01

We analyse in a theoretical framework the link between real-time and day-ahead market performance in a hydro-based and imperfectly competitive wholesale electricity market. Theoretical predictions of the model are tested on data from the Nordic power exchange, Nord Pool Spot (NPS).We reject the hypothesis that prices at NPS were at their competitive levels throughout the period under examination. The empirical approach uses equilibrium prices and quantities and does not rely on bid data nor o...

Do Culture-based Segments Predict Selection of Market Strategy?

Directory of Open Access Journals (Sweden)

Veronika Jadczaková

2015-01-01

Full Text Available Academists and practitioners have already acknowledged the importance of unobservable segmentation bases (such as psychographics yet still focusing on how well these bases are capable of describing relevant segments (the identifiability criterion rather than on how precisely these segments can predict (the predictability criterion. Therefore, this paper intends to add a debate to this topic by exploring whether culture-based segments do account for a selection of market strategy. To do so, a set of market strategy variables over a sample of 251 manufacturing firms was first regressed on a set of 19 cultural variables using canonical correlation analysis. Having found significant relationship in the first canonical function, it was further examined by means of correspondence analysis which cultural segments – if any – are linked to which market strategies. However, as correspondence analysis failed to find a significant relationship, it may be concluded that business culture might relate to the adoption of market strategy but not to the cultural groupings presented in the paper.

An agent-based simulation of power generation company behavior in electricity markets under different market-clearing mechanisms

International Nuclear Information System (INIS)

Aliabadi, Danial Esmaeili; Kaya, Murat; Şahin, Güvenç

2017-01-01

Deregulated electricity markets are expected to provide affordable electricity for consumers through promoting competition. Yet, the results do not always fulfill the expectations. The regulator's market-clearing mechanism is a strategic choice that may affect the level of competition in the market. We conceive of the market-clearing mechanism as composed of two components: pricing rules and rationing policies. We investigate the strategic behavior of power generation companies under different market-clearing mechanisms using an agent-based simulation model which integrates a game-theoretical understanding of the auction mechanism in the electricity market and generation companies' learning mechanism. Results of our simulation experiments are presented using various case studies representing different market settings. The market in simulations is observed to converge to a Nash equilibrium of the stage game or to a similar state under most parameter combinations. Compared to pay-as-bid pricing, bid prices are closer to marginal costs on average under uniform pricing while GenCos' total profit is also higher. The random rationing policy of the ISO turns out to be more successful in achieving lower bid prices and lower GenCo profits. In minimizing GenCos' total profit, a combination of pay-as-bid pricing rule and random rationing policy is observed to be the most promising. - Highlights: • An agent-based simulation of generation company behavior in electricity markets is developed. • Learning dynamics of companies is modeled with an extended Q-learning algorithm. • Different market clearing mechanisms of the regulator are compared. • Convergence to Nash equilibria is analyzed under different cases. • The level of competition in the market is studied.

Use of the conditional marketing authorization pathway for oncology medicines in Europe.

Science.gov (United States)

Hoekman, J; Boon, W P C; Bouvy, J C; Ebbers, H C; de Jong, J P; De Bruin, M L

2015-11-01

Conditional marketing authorization (CMA) in the European Union (EU) is an early access pathway for medicines that show promising therapeutic effects, but for which comprehensive data are not available. Using a mixed quantitative-qualitative research design, we evaluated how CMA has been used in marketing authorization of oncology medicines in the period 2006 to 2013. We show that compared to full marketing authorization, CMA is granted based on less comprehensive data. However, this is accompanied by significantly longer assessment times and less consensus among regulators about marketing authorization. Moreover, development time from first-in-human testing to marketing authorization did not differ between full marketing authorization and CMA, but was significantly longer for CMA compared to accelerated approved products in the United States (US). Results indicate that CMA is not used by companies as a prospectively planned pathway to obtain early access, but as a "rescue option" when submitted data are not strong enough to justify full marketing authorization. © 2015, The American Society for Clinical Pharmacology and Therapeutics.

Far-Infrared Based Pedestrian Detection for Driver-Assistance Systems Based on Candidate Filters, Gradient-Based Feature and Multi-Frame Approval Matching.

Science.gov (United States)

Wang, Guohua; Liu, Qiong

2015-12-21

Far-infrared pedestrian detection approaches for advanced driver-assistance systems based on high-dimensional features fail to simultaneously achieve robust and real-time detection. We propose a robust and real-time pedestrian detection system characterized by novel candidate filters, novel pedestrian features and multi-frame approval matching in a coarse-to-fine fashion. Firstly, we design two filters based on the pedestrians' head and the road to select the candidates after applying a pedestrian segmentation algorithm to reduce false alarms. Secondly, we propose a novel feature encapsulating both the relationship of oriented gradient distribution and the code of oriented gradient to deal with the enormous variance in pedestrians' size and appearance. Thirdly, we introduce a multi-frame approval matching approach utilizing the spatiotemporal continuity of pedestrians to increase the detection rate. Large-scale experiments indicate that the system works in real time and the accuracy has improved about 9% compared with approaches based on high-dimensional features only.

Far-Infrared Based Pedestrian Detection for Driver-Assistance Systems Based on Candidate Filters, Gradient-Based Feature and Multi-Frame Approval Matching

Directory of Open Access Journals (Sweden)

Guohua Wang

2015-12-01

Full Text Available Far-infrared pedestrian detection approaches for advanced driver-assistance systems based on high-dimensional features fail to simultaneously achieve robust and real-time detection. We propose a robust and real-time pedestrian detection system characterized by novel candidate filters, novel pedestrian features and multi-frame approval matching in a coarse-to-fine fashion. Firstly, we design two filters based on the pedestrians’ head and the road to select the candidates after applying a pedestrian segmentation algorithm to reduce false alarms. Secondly, we propose a novel feature encapsulating both the relationship of oriented gradient distribution and the code of oriented gradient to deal with the enormous variance in pedestrians’ size and appearance. Thirdly, we introduce a multi-frame approval matching approach utilizing the spatiotemporal continuity of pedestrians to increase the detection rate. Large-scale experiments indicate that the system works in real time and the accuracy has improved about 9% compared with approaches based on high-dimensional features only.

Shippers and Network Capacity Booking in the Dutch Gas Market

NARCIS (Netherlands)

Bucura, C.; Lukszo, Z.

2012-01-01

The main objectives of the Third Gas Directive (2009/73EC) approved by the European Union are: unbundling, creating an independent Transport Service Operator (TSO) and ensuring free access to the market. The separation of gas trading from transportation activities required new market rules and gas

Teaching Innovations in Marketing: A Brand-Based Student-Led Inquiry of Marketing Concepts and Practices

Science.gov (United States)

Hostetter, Leonard R., Jr.

2017-01-01

This teaching innovation is a brand-based student-led inquiry of marketing concepts and practices for an introductory marketing course. During the first week of class, teams of students (or individual students) each select a brand of interest to research and analyze throughout the course. The objective is for students to understand the practical…

Creating lift versus building the base : Current trends in marketing dynamics

NARCIS (Netherlands)

Leeflang, P.S.H.; Bijmolt, T.H.A.; van Doorn, J.; Hanssens, D.M.; van Heerde, H.J.; Verhoef, P.C.; Wieringa, J.E.

Markets are dynamic by nature; and marketing-efforts can be directed to stimulate, reduce, or to utilize these dynamics. The field of marketing dynamics aims at modeling the effects of marketing actions and policies on short-term performance ("lift") and on long-term performance ("base"). One of the

A critical survey of agent-based wholesale electricity market models

International Nuclear Information System (INIS)

Weidlich, Anke; Veit, Daniel

2008-01-01

The complexity of electricity markets calls for rich and flexible modeling techniques that help to understand market dynamics and to derive advice for the design of appropriate regulatory frameworks. Agent-Based Computational Economics (ACE) is a fairly young research paradigm that offers methods for realistic electricity market modeling. A growing number of researchers have developed agent-based models for simulating electricity markets. The diversity of approaches makes it difficult to overview the field of ACE electricity research; this literature survey should guide the way through and describe the state-of-the-art of this research area. In a conclusive summary, shortcomings of existing approaches and open issues that should be addressed by ACE electricity researchers are critically discussed. (author)

Conditional approval: Japan lowers the bar for regenerative medicine products.

Science.gov (United States)

Sipp, Douglas

2015-04-02

A new system for conditional approval of regenerative medicine products will allow products of undetermined efficacy to enter the Japanese market. The potential scientific, economic, and ethical implications of this program highlight the need for further discussion and refinement. Copyright © 2015 Elsevier Inc. All rights reserved.

13 CFR 120.1716 - Required SBA approval of servicing actions.

Science.gov (United States)

2010-01-01

... 13 Business Credit and Assistance 1 2010-01-01 2010-01-01 false Required SBA approval of servicing actions. 120.1716 Section 120.1716 Business Credit and Assistance SMALL BUSINESS ADMINISTRATION BUSINESS LOANS Establishment of SBA Secondary Market Guarantee Program for First Lien Position 504 Loan Pools...

Strategy-Based Segmentation of Industrial Markets

NARCIS (Netherlands)

Verhallen, Theo M.M.; Frambach, Ruud T.; Prabhu, Jaideep

Segmentation of industrial markets is typically based on observable characteristics of firms such as their location and size. However, such variables have been found to be poor predictors of industrial buying behavior. To improve the effectiveness and power of existing approaches to industrial

77 FR 24399 - Approval and Promulgation of Implementation Plans; Georgia; Atlanta; Ozone 2002 Base Year...

Science.gov (United States)

2012-04-24

... Promulgation of Implementation Plans; Georgia; Atlanta; Ozone 2002 Base Year Emissions Inventory AGENCY... approve the ozone 2002 base year emissions inventory, portion of the state implementation plan (SIP... technology (RACT), contingency measures, a 2002 base- year emissions inventory and other planning SIP...

The liberalization of gas markets in Europe

International Nuclear Information System (INIS)

Lecarpentier, A.

2006-01-01

On June 22, 1998 all EU Member States unanimously approved Directive 98/30/EC, the so-called Gas Directive, which paved the way for far-reaching changes in the European gas sector and for the establishment of an internal gas market. Five years have elapsed since it was transposed into national law and although markets have started to open up, their rate of progress varies. The next milestone in achieving a fully competitive European market is July 1, 2007, but there are still many obstacles to overcome. (author)

The liberalization of gas market in Europe

International Nuclear Information System (INIS)

Lecarpentier, Armelle

2006-01-01

On June 22, 1998, all EU Member States unanimously approved Directive 98/30/EC, the so-called Gas Directive, which paved the way for far-reaching changes in the European gas Sector and for the establishment of an internal gas market. Five years have elapsed since it was transposed into national law and although markets have started to open up, their rate of progress varies. The next milestone in achieving a fully competitive European market is July 1, 2007, but there are still many obstacles to overcome [it

30 CFR 14.10 - Post-approval product audit.

Science.gov (United States)

2010-07-01

..., AND APPROVAL OF MINING PRODUCTS REQUIREMENTS FOR THE APPROVAL OF FLAME-RESISTANT CONVEYOR BELTS General Provisions § 14.10 Post-approval product audit. (a) Approved conveyor belts will be subject to... based. MSHA will select an approved conveyor belt to be audited; the selected belt will be...

Tribal Community-Based Social Marketing Training Guide

Science.gov (United States)

The Community-Based Social Marketing (CBSM) Training Guide and recycling toolkit provides an overview of how to increase the adoption of sustainable behaviors and recycling practices with a community.

Wildlife based business activities in Ogbe–Ijaw market of Delta state ...

African Journals Online (AJOL)

Wildlife based business activities in Ogbe–Ijaw market of Delta state, Nigeria. ... of procuring the products, channels for marketing the products, and risks involved in procuring wildlife products sold in the market. ... AJOL African Journals Online.

Robust Market Launch Planning for a Multi- Echelon Pharmaceutical Supply Chain

DEFF Research Database (Denmark)

Hansen, Klaus Reinholdt Nyhuus; Grunow, Martin; Gani, Rafiqul

2011-01-01

launching activities after the drug has been approved. In this paper, we present a recourse-based stochastic model, which allows for time phasing the market entries to balance the fluctuating demand with the fixed and periodic production of the active pharmaceutical ingredient. The two major risk elements...... during launch are forecasting inaccuracy and the risk of a required label change from local regulatory authorities. Robust solutions are found by implementing the Robust Optimization framework....

21 CFR 312.84 - Risk-benefit analysis in review of marketing applications for drugs to treat life-threatening and...

Science.gov (United States)

2010-04-01

... making the final decision on approvability. As part of this evaluation, consistent with the statement of.... (b) In making decisions on whether to grant marketing approval for products that have been the... 21 Food and Drugs 5 2010-04-01 2010-04-01 false Risk-benefit analysis in review of marketing...

A study of market efficiency in the stock market, forex market and bullion market in India

OpenAIRE

Sarker, Debnarayan; Ghosh, Bikash Kumar

2007-01-01

This study suggests that, run test, which are based on signs of indices / rates, do not reject efficient market hypothesis in the case of all the three markets, whereas VR tests, which capture the variation in permanent component of the series as a ratio to the total variation, reject the efficient market hypothesis in the case of the gold markets. Efficient market hypothesis in the case of Stock markets, Forex markets and Silver markets cannot be rejected based on VR tests. Since VR tests a...

CSC Tip Sheets: Community-Based Social Marketing

Science.gov (United States)

Use community-based social marketing (CBSM) to facilitate direct neighbor-to-neighbor communication and influence to promote behavior change. In-person communications are often complemented by electronic social media tools.

Issues in Water Quality Trading: Perspectives on the Market-Based Approach

Science.gov (United States)

Market mechanisms and incentives can play an important role in addressing environmental problems. Potential advantages of using market-based approaches include reducing the costs of meeting environmental goals and encouraging innovation. One market mechanism that has been promo...

Regional markets with agricultural workforce based on Labour offices' data

Directory of Open Access Journals (Sweden)

František Nohel

2011-01-01

Full Text Available The changes in Czech agriculture over the past twenty years have had their impact on the agricultural labour market, too. The regional differentiation of the chances of applicants on the labour market as well as the agricultural enterprises’ chances of hiring employees fitting their requirements, are, among others, influenced by the specific conditions of agricultural production. The aim of this paper pertains to two basic problem areas: first, the differentiation of respective regions based on the number of agricultural applicants and job vacancies, and second, the identification of disequilibrium on the agricultural labour market. The latter is based on a theoretical framework defined by approaches in economy dealing with labour market equilibrium. Due to the unavailability of economic data (including wages, economic performance, etc. on the regional level, authors develop their own methodological approach, based on the number of applicants per job vacancy. A database of applicants and vacancies available from the Labour Offices is used as a source for the analysis and interpretation of data, enabling us to study the agricultural labour market not only sector-wise but also region-wise.

7 CFR 1486.302 - Can changes be made to a project once it has been approved?

Science.gov (United States)

2010-01-01

... 7 Agriculture 10 2010-01-01 2010-01-01 false Can changes be made to a project once it has been... MARKETS PROGRAM Program Operations § 1486.302 Can changes be made to a project once it has been approved? (a) Approved projects may be modified if circumstances change in such a way that they would likely...

Consentaneous agent-based and stochastic model of the financial markets.

Science.gov (United States)

Gontis, Vygintas; Kononovicius, Aleksejus

2014-01-01

We are looking for the agent-based treatment of the financial markets considering necessity to build bridges between microscopic, agent based, and macroscopic, phenomenological modeling. The acknowledgment that agent-based modeling framework, which may provide qualitative and quantitative understanding of the financial markets, is very ambiguous emphasizes the exceptional value of well defined analytically tractable agent systems. Herding as one of the behavior peculiarities considered in the behavioral finance is the main property of the agent interactions we deal with in this contribution. Looking for the consentaneous agent-based and macroscopic approach we combine two origins of the noise: exogenous one, related to the information flow, and endogenous one, arising form the complex stochastic dynamics of agents. As a result we propose a three state agent-based herding model of the financial markets. From this agent-based model we derive a set of stochastic differential equations, which describes underlying macroscopic dynamics of agent population and log price in the financial markets. The obtained solution is then subjected to the exogenous noise, which shapes instantaneous return fluctuations. We test both Gaussian and q-Gaussian noise as a source of the short term fluctuations. The resulting model of the return in the financial markets with the same set of parameters reproduces empirical probability and spectral densities of absolute return observed in New York, Warsaw and NASDAQ OMX Vilnius Stock Exchanges. Our result confirms the prevalent idea in behavioral finance that herding interactions may be dominant over agent rationality and contribute towards bubble formation.

A Study on Market-based Strategic Procurement Planning in Convergent Supply Networks

Science.gov (United States)

Opadiji, Jayeola Femi; Kaihara, Toshiya

We present a market-based decentralized approach which uses a market-oriented programming algorithm to obtain Pareto-optimal allocation of resources traded among agents which represent enterprise units in a supply network. The proposed method divides the network into a series of Walrsian markets in order to obtain procurement budgets for enterprises in the network. An interaction protocol based on market value propagation is constructed to coordinate the flow of resources across the network layers. The method mitigates the effect of product complementarity in convergent network by allowing for enterprises to hold private valuations of resources in the markets.

Approval of the first biosimilar antibodies in Europe: a major landmark for the biopharmaceutical industry.

Science.gov (United States)

Beck, Alain; Reichert, Janice M

2013-01-01

In a defining moment for the European Medicines Agency (EMA) and the biopharmaceutical industry, on June 27, 2013 EMA's Committee for Medicinal Products for Human Use adopted a positive opinion for two biosimilar infliximab products (Celltrion's Remsima® and Hospira's Inflectra®), and recommended that they be approved for marketing in the European Union (EU). The European Commission's decision on an application is typically issued 67 d after an opinion is provided; thus, decisions are expected in early September 2013. If approved, the products will comprise the first biosimilar antibody made available to patients in a highly regulated market, although launch may be delayed due to an extension of the reference product's (Remicade®) patent in the EU.

Conjectural variation based learning model of strategic bidding in spot market

International Nuclear Information System (INIS)

Yiqun Song; Yixin Ni; Fushuan Wen; Wu, F.F.

2004-01-01

In actual electricity market, which operates repeatedly on the basis of one hour or half hour, each firm might learn or estimate other competitors' strategic behaviors from available historical market operation data, and rationally aims at its maximum profit in the repeated biddings. A conjectural variation based learning method is proposed in this paper for generation firm to improve its strategic bidding performance. In the method, each firm learns and dynamically regulates its conjecture upon the reactions of its rivals to its bidding according to available information published in the electricity market, and then makes its optimal generation decision based on the updated conjectural variation of its rivals. Through such learning process, the equilibrium reached in the market is proven a Nash equilibrium. Motivation of generation firm to learn in the changing market environment and consequence of learning behavior in the market are also discussed through computer tests. (author)

Simulating GenCo bidding strategies in electricity markets with an agent-based model

International Nuclear Information System (INIS)

Botterud, Audun; Thimmapuram, Prakash R.; Yamakado, Malo

2005-01-01

In this paper we use an agent-based simulation model, EMCAS, to analyze market power in electricity markets. We focus on the effect of congestion management on the ability of generating companies (GenCos) to raise prices beyond competitive levels. An 11-node test power system is used to compare a market design based on locational marginal pricing with a market design that uses system marginal pricing and congestion management by counter trading. Bidding strategies based on both physical and economic withholding are compared to a base case with production cost bidding. The results show that unilateral market power is exercised under both pricing mechanisms. However, the largest changes in consumer costs and GenCo profits due to strategic bidding occur under the locational marginal pricing scheme. The analysis also illustrates that agent-based modeling can contribute important insights into the complex interactions between the participants in transmission-constrained electricity markets. (Author)

Analysis on the inbound tourist source market in Jiangxi based on geographic concentration index and market competition status

Science.gov (United States)

Yu, Tong; Ye, Yue-li

2018-05-01

In accordance with the related data of Statistical Yearbook of Jiangxi (2007—2016), conduct analysis on the development situation of inbound tourist source market in Jiangxi based on geographic concentration index and market competition status. The result shows: when the geographic concentration index of the inbound tourism market in Jiangxi presents an increasing decline trend, the tourism-generating countries of the inbound tourism in Jiangxi are getting more and more disperse, the tourist markets present the diversified feature and the inbound tourism market tends to be stable; besides, the analysis result of the market competition status shows that the inbound tourism development in Jiangxi has transformed from the rapid development to stable development.

77 FR 26441 - Approval and Promulgation of Implementation Plans; North Carolina; Charlotte; Ozone 2002 Base...

Science.gov (United States)

2012-05-04

... Promulgation of Implementation Plans; North Carolina; Charlotte; Ozone 2002 Base Year Emissions Inventory... final action to approve the ozone 2002 base year emissions inventory portion of the state implementation... Air Act (CAA or Act). EPA will take action on the South Carolina submission for the ozone 2002 base...

pCloud: A Cloud-based Power Market Simulation Environment

Energy Technology Data Exchange (ETDEWEB)

Rudkevich, Aleksandr; Goldis, Evgeniy

2012-12-02

This research conducted by the Newton Energy Group, LLC (NEG) is dedicated to the development of pCloud: a Cloud-based Power Market Simulation Environment. pCloud is offering power industry stakeholders the capability to model electricity markets and is organized around the Software as a Service (SaaS) concept -- a software application delivery model in which software is centrally hosted and provided to many users via the internet. During the Phase I of this project NEG developed a prototype design for pCloud as a SaaS-based commercial service offering, system architecture supporting that design, ensured feasibility of key architecture's elements, formed technological partnerships and negotiated commercial agreements with partners, conducted market research and other related activities and secured funding for continue development of pCloud between the end of Phase I and beginning of Phase II, if awarded. Based on the results of Phase I activities, NEG has established that the development of a cloud-based power market simulation environment within the Windows Azure platform is technologically feasible, can be accomplished within the budget and timeframe available through the Phase II SBIR award with additional external funding. NEG believes that pCloud has the potential to become a game-changing technology for the modeling and analysis of electricity markets. This potential is due to the following critical advantages of pCloud over its competition: - Standardized access to advanced and proven power market simulators offered by third parties. - Automated parallelization of simulations and dynamic provisioning of computing resources on the cloud. This combination of automation and scalability dramatically reduces turn-around time while offering the capability to increase the number of analyzed scenarios by a factor of 10, 100 or even 1000. - Access to ready-to-use data and to cloud-based resources leading to a reduction in software, hardware, and IT costs

New drugs: evidence relating to their therapeutic value after introduction to the market.

Science.gov (United States)

Ujeyl, Mariam; Schlegel, Claudia; Walter, Siegbert; Gundert-Remy, Ursula

2012-02-01

Drug approval is based on three criteria: quality, efficacy, and safety. We investigated the types of study design and statistical methods employed to demonstrate safety and efficacy of proprietary medicinal products (PMPs) that were approved for use in the European Union through the centralized procedure. We retrospectively analyzed the European Public Assessment Reports of PMPs that the European Medicinal Agency approved, either initially or for extended indications, in 2009 and 2010. Data were analyzed for 39 PMPs: 64% of these were new active substances, and 36% were approved for extended indications. 46% of the PMPs had been studied in an active-control trial. In only 28%, superiority of the new PMPs compared to active control had been tested. 46% of the approvals included testing of a patient-relevant primary endpoint. The median size of population used to demonstrate safety was 1700 persons. The centralized procedure does not require comparative information from active-control trials. Accordingly, as our descriptive analysis revealed, this information is often not available at the time of market introduction. Pivotal studies only rarely clearly demonstrate an added therapeutic value of a new PMP compared to existing alternatives.

77 FR 38879 - Self-Regulatory Organizations; NYSE Arca, Inc.; Order Granting Approval of Proposed Rule Change...

Science.gov (United States)

2012-06-29

... marketable non-displayed interest, the Market Maker would be required to re-enter a quotation for purposes of...-Regulatory Organizations; NYSE Arca, Inc.; Order Granting Approval of Proposed Rule Change Adding New... Securities Exchange Act of 1934 (``Act'') \\1\\ and Rule 19b-4 thereunder,\\2\\ a proposed rule change to add new...

Patient-Centered Drug Approval: The Role of Patient Advocacy in the Drug Approval Process.

Science.gov (United States)

Mattingly, T Joseph; Simoni-Wastila, Linda

2017-10-01

Recent approval of eteplirsen for Duchenne muscular dystrophy (DMD), a rare disease with few treatment alternatives, has reignited the debate over the U.S. drug approval process. The evolution of legal and regulatory restrictions to the marketing and sale of pharmaceuticals has spanned more than a century, and throughout this history, patient advocacy has played a significant role. Scientific evidence from clinical trials serves as the foundation for drug approval, but the patient voice has become increasingly influential. Although the gold standard for establishing safety and efficacy through randomized controlled trials has been in place for more than 50 years, it poses several limitations for rare disorders where patient recruitment for traditional clinical trials is a major barrier. Organized efforts by patient advocacy groups to help patients with rare diseases access investigational therapy have had a legislative and regulatory effect. After approval by the FDA, patient access to therapy may still be limited by cost. A managed care organization (MCO) with the fiduciary responsibility of managing the health of a population must weigh coverage decisions for costly therapies with questionable effectiveness against alternatives within the constraint of a finite budget. Even when the FDA deems a drug safe and effective, an MCO may determine that the drug should only be made available at a tier level where out-of-pocket costs are still too high for many patients. This limitation of availability may be due to cost, other treatment alternatives, or outcomes from existing clinical evidence. However, if the MCO makes a costly new treatment for a rare disease readily available, it may temporarily satisfy a small contingency at the cost of all of its members. This article examines the risks and benefits of patient-centered drug approval and the potential economic effect of patient-centered drug approval on population health. There is no funding to disclose. Mattingly

An auction game model for pool-based electricity markets

International Nuclear Information System (INIS)

Gan, Deqiang; Wang, Jianquan; Bourcier, Donald V.

2005-01-01

A single-period auction game model for analyzing strategic behavior in pool-based electricity markets is introduced in the paper. We study the Nash equilibrium in a pure strategy sense of such games. First an equilibrium existence lemma is proved. Equilibrium characterization under tight capacity constraints is provided. Then it is demonstrated that an auction game does not possess a pure strategy Nash equilibrium under a wide range of market conditions. The paper provides a characterization of equilibrium under weak capacity constraints. We apply the introduced results to analyze market power indices presented in our earlier work and in related reports. Applications to actual market analysis, as well as limitations of the introduced model are provided. (author)

Modeling investor sentiment and overconfidence in an agent-based stock market

NARCIS (Netherlands)

Lovric, M.; Kaymak, U.; Spronk, J.

2010-01-01

Agent-based stock markets as bottom-up models of financial markets allow us to study the link between individual investor behavior and aggregate market phenomena, and as such are a useful tool for investigating the implications of behavioral finance and investor psychology. In this paper we want to

Agent-Based Modeling of Day-Ahead Real Time Pricing in a Pool-Based Electricity Market

Directory of Open Access Journals (Sweden)

Sh. Yousefi

2011-09-01

Full Text Available In this paper, an agent-based structure of the electricity retail market is presented based on which day-ahead (DA energy procurement for customers is modeled. Here, we focus on operation of only one Retail Energy Provider (REP agent who purchases energy from DA pool-based wholesale market and offers DA real time tariffs to a group of its customers. As a model of customer response to the offered real time prices, an hourly acceptance function is proposed in order to represent the hourly changes in the customer’s effective demand according to the prices. Here, Q-learning (QL approach is applied in day-ahead real time pricing for the customers enabling the REP agent to discover which price yields the most benefit through a trial-and-error search. Numerical studies are presented based on New England day-ahead market data which include comparing the results of RTP based on QL approach with that of genetic-based pricing.

Global Distribution of Businesses Marketing Stem Cell-Based Interventions.

Science.gov (United States)

Berger, Israel; Ahmad, Amina; Bansal, Akhil; Kapoor, Tanvir; Sipp, Douglas; Rasko, John E J

2016-08-04

A structured search reveals that online marketing of stem-cell-based interventions is skewed toward developed economies including the United States, Ireland, Australia, and Germany. Websites made broad, imprecise therapeutic claims and frequently failed to detail procedures. Widespread marketing poses challenges to regulators, bioethicists, and those seeking realistic hope from therapies. Copyright © 2016 Elsevier Inc. All rights reserved.

18 CFR 284.502 - Procedures for applying for market-based rates.

Science.gov (United States)

2010-04-01

... 18 Conservation of Power and Water Resources 1 2010-04-01 2010-04-01 false Procedures for applying for market-based rates. 284.502 Section 284.502 Conservation of Power and Water Resources FEDERAL... POLICY ACT OF 1978 AND RELATED AUTHORITIES Applications for Market-Based Rates for Storage § 284.502...

Space Situational Awareness using Market Based Agents

Science.gov (United States)

Sullivan, C.; Pier, E.; Gregory, S.; Bush, M.

2012-09-01

Space surveillance for the DoD is not limited to the Space Surveillance Network (SSN). Other DoD-owned assets have some existing capabilities for tasking but have no systematic way to work collaboratively with the SSN. These are run by diverse organizations including the Services, other defense and intelligence agencies and national laboratories. Beyond these organizations, academic and commercial entities have systems that possess SSA capability. Most all of these assets have some level of connectivity, security, and potential autonomy. Exploiting them in a mutually beneficial structure could provide a more comprehensive, efficient and cost effective solution for SSA. The collection of all potential assets, providers and consumers of SSA data comprises a market which is functionally illiquid. The development of a dynamic marketplace for SSA data could enable would-be providers the opportunity to sell data to SSA consumers for monetary or incentive based compensation. A well-conceived market architecture could drive down SSA data costs through increased supply and improve efficiency through increased competition. Oceanit will investigate market and market agent architectures, protocols, standards, and incentives toward producing high-volume/low-cost SSA.

Digital mammography. Why hasn't it been approved for U.S. hospitals?

Science.gov (United States)

2000-01-01

Mammography is the only major imaging technique still unavailable in the United States in digital form. This is because the Food and Drug Administration (FDA) has been unable to devise an effective method for manufacturers to demonstrate the safety and efficacy of digital mammography systems. As a result, the agency has been unable to approve any of those systems for marketing in the United States. In this Regulatory Update, we describe FDA's recent efforts to help manufacturers obtain approval and the reasons those efforts have so far proved ineffective.

77 FR 24440 - Approval and Promulgation of Implementation Plans; Georgia; Atlanta; Ozone 2002 Base Year...

Science.gov (United States)

2012-04-24

... ENVIRONMENTAL PROTECTION AGENCY 40 CFR Part 52 [EPA-R04-OAR-2010-0021(b); FRL-9661-9] Approval and Promulgation of Implementation Plans; Georgia; Atlanta; Ozone 2002 Base Year Emissions Inventory AGENCY... 2002 base year emissions inventory portion of the state implementation plan (SIP) revision submitted by...

Emerging Market Firms’ Acquisitions in Advanced Markets

DEFF Research Database (Denmark)

Stucchi, Tamara

2012-01-01

markets. These antecedents can influence emerging market firms’ capacities to absorb or exploit technological and/or marketing advantages in advanced markets. In order to be successful, emerging market firms have to undertake those upmarket acquisitions that best “fit” their antecedents. Four mutually......This study draws upon the resource-based view and the institution-based view of the firm to provide a comprehensive overview of how different resource-, institution- and industry-based antecedents affect the motivations guiding the acquisitions that emerging market firms undertake in advanced...... exclusive acquisition strategies are derived, which are then illustrated using examples of Indian firms’ acquisitions in advanced markets....

Labour market participants’ competitiveness assessment based on latent variables theory

Directory of Open Access Journals (Sweden)

T. V. Sabetova

2017-01-01

Full Text Available The article suggests innovative model for assessment of labour market subjects’ competitiveness, or successfulness. The authors state that general complex indicator for individual competitiveness within the labour market cannot be identified. Instead, precise enough assessment of such competitiveness can be based on some variables, though different for in-house and external labour market. The model of latent variables’ assessment based on Rasch’s method was selected as the base for the suggested method. The assessment model gives unbiased generalized values of subjects’ competitiveness on the linear non-dimensional scale based on the partial estimates of the selected criteria. The free choice of these criteria allows the model’s appliance for various labour market segments. The article demonstrates the mathematical grounding for the model; methodic of the assessment criteria selection; the way of assessment performance using MS Excel. It also analyses the features of the obtained estimates and shows their comparison with the estimates obtained by traditional methods. The model suggested by the authors can introduce any quantitative parameter of competitiveness as a variable after analysis of the factors affecting it. The quantitative estimates of these factors become the model’s criteria, but the assessment precision does not alter.

A Computational Agent-Based Modeling Approach for Competitive Wireless Service Market

KAUST Repository

Douglas, C C

2011-04-01

Using an agent-based modeling method, we study market dynamism with regard to wireless cellular services that are in competition for a greater market share and profit. In the proposed model, service providers and consumers are described as agents who interact with each other and actively participate in an economically well-defined marketplace. Parameters of the model are optimized using the Levenberg-Marquardt method. The quantitative prediction capabilities of the proposed model are examined through data reproducibility using past data from the U.S. and Korean wireless service markets. Finally, we investigate a disruptive market event, namely the introduction of the iPhone into the U.S. in 2007 and the resulting changes in the modeling parameters. We predict and analyze the impacts of the introduction of the iPhone into the Korean wireless service market assuming a release date of 2Q09 based on earlier data. © 2011 IEEE.

Model-based synthesis of locally contingent responses to global market signals

Science.gov (United States)

Magliocca, N. R.

2015-12-01

Rural livelihoods and the land systems on which they depend are increasingly influenced by distant markets through economic globalization. Place-based analyses of land and livelihood system sustainability must then consider both proximate and distant influences on local decision-making. Thus, advancing land change theory in the context of economic globalization calls for a systematic understanding of the general processes as well as local contingencies shaping local responses to global signals. Synthesis of insights from place-based case studies of land and livelihood change is a path forward for developing such systematic knowledge. This paper introduces a model-based synthesis approach to investigating the influence of local socio-environmental and agent-level factors in mediating land-use and livelihood responses to changing global market signals. A generalized agent-based modeling framework is applied to six case-study sites that differ in environmental conditions, market access and influence, and livelihood settings. The largest modeled land conversions and livelihood transitions to market-oriented production occurred in sties with relatively productive agricultural land and/or with limited livelihood options. Experimental shifts in the distributions of agents' risk tolerances generally acted to attenuate or amplify responses to changes in global market signals. Importantly, however, responses of agents at different points in the risk tolerance distribution varied widely, with the wealth gap growing wider between agents with higher or lower risk tolerance. These results demonstrate model-based synthesis is a promising approach to overcome many of the challenges of current synthesis methods in land change science, and to identify generalized as well as locally contingent responses to global market signals.

75 FR 53727 - Self-Regulatory Organizations; NASDAQ OMX PHLX, Inc.; Order Approving Proposed Rule Change, as...

Science.gov (United States)

2010-09-01

... underwritings; (ii) supervision of market making commitments; (iii) final approval of advertisements as these... designed to prevent fraudulent and manipulative acts and practices, to promote just and equitable...

A Study Effects Architectural Marketing Capabilities on Performance Marketing unit Based on: Morgan et al case: Past Industry in Tehran

OpenAIRE

Mohammad Reza Dalvi; Robabe Seifi

2014-01-01

Over a period of time architectural marketing capabilities combination of knowledge and skills develop in to capabilities. These architectural marketing capabilities have been identified as one of the important ways firms can achieve a competitive advantage The following research tests effects architectural marketing capabilities on performance marketing unit Based on a survey .a structural equation model was developed to test our hypotheses. the study develops a structural model linking arch...

Six-Month Market Exclusivity Extensions To Promote Research Offer Substantial Returns For Many Drug Makers.

Science.gov (United States)

Kesselheim, Aaron S; Rome, Benjamin N; Sarpatwari, Ameet; Avorn, Jerry

2017-02-01

To incentivize pharmaceutical manufacturers to invest in areas of unmet medical need, policy makers frequently propose extending the market exclusivity period of desired drugs. Some such proposals are modeled after the pediatric exclusivity patent extension program, which since 1997 has provided six additional months of market exclusivity for drugs studied in children. The most recent proposal would encourage rare disease research by providing six months of extended exclusivity for any existing drug that is granted subsequent FDA approval for a new rare disease indication. Yet the economic impact of such proposals is rarely addressed. We found that for the thirteen FDA-approved drugs that gained supplemental approval for a rare disease indication from 2005 through 2010, the median projected cost of clinical trials leading to approval was $29.8 million. If the exclusivity extension had been in place, the median discounted financial gain to manufacturers would have been $94.6 million. Median net returns would have been $82.4 million, with higher returns for drugs with higher annual sales. Extending market exclusivity would provide substantial compensation to many manufacturers, particularly for top-selling products, far in excess of the cost of conducting these trials. Alternative strategies to incentivize the study of approved drugs for rare diseases may offer similar benefits at a lower cost. Project HOPE—The People-to-People Health Foundation, Inc.

Multi-dimensional information diffusion and balancing market supply: an agent-based approach

NARCIS (Netherlands)

Osinga, S.A.; Kramer, M.R.; Hofstede, G.J.; Beulens, A.J.M.

2013-01-01

This agent-based information management model is designed to explore how multi-dimensional information, spreading through a population of agents (for example farmers) affects market supply. Farmers make quality decisions that must be aligned with available markets. Markets distinguish themselves by

78 FR 44922 - Vegetable and Specialty Crop Marketing Orders; Notice of Request for Extension and Revision of a...

Science.gov (United States)

2013-07-25

... Approved Information Collection AGENCY: Agricultural Marketing Service, USDA. ACTION: Notice and request... assured of consideration. Additional Information or Comments: Contact Andrew Hatch, Supervisory Marketing....regulations.gov . SUPPLEMENTARY INFORMATION: Title: Vegetable and Specialty Crop Marketing Orders. OMB Number...

Local labor markets and taste-based discrimination

Directory of Open Access Journals (Sweden)

Clémence Berson

2016-04-01

Full Text Available Abstract This article appeals to heterogeneity in workers’ non-wage preferences to model taste-based discrimination. Firms hire both types of workers and pay lower wages to minority workers, whatever their taste for discrimination. A single prejudiced firm in the market produces a substantial wage gap in all firms. Consequently, discrimination allows unprejudiced firms to make non-zero profits, so that they have little incentive to drive out prejudiced firms. As the market does not eliminate discrimination, state intervention is required. Indirect policies do not affect the absolute wage gap between the two groups, but may be more likely to be used than direct policies.

77 FR 42686 - Approval and Promulgation of Air Quality Implementation Plans; Maryland; the 2002 Base Year...

Science.gov (United States)

2012-07-20

... Promulgation of Air Quality Implementation Plans; Maryland; the 2002 Base Year Inventory AGENCY: Environmental... matter (PM 2.5 ) 2002 base year emissions inventory portion of the Maryland State Implementation Plan... National Ambient Air Quality Standard (NAAQS) SIP. EPA is proposing to approve the 2002 base year PM 2.5...

75 FR 38516 - Order on Intent To Revoke Market-Based Rate Authority

Science.gov (United States)

2010-07-02

..., Electric Quarterly Reports, Strategic Energy Management Corp., Solaro Energy Marketing Corporation. 1... (including market-based power sales, cost-based power sales, and transmission service) and providing transaction information (including rates) for short-term and long-term power sales during the most recent...

MARKET WATCH

Institute of Scientific and Technical Information of China (English)

2009-01-01

Pork prices in Beijing remained relatively stable despite the swine flu outbreak in Mexico. China’s job market is still in the doldrums with the registered urban jobless rising slightly in the first quarter. The government is preparing to issue the third tranche of its stimulus package. China Minmetals Corp. received approval from the Australian Treasury to buy the assets of Oz Minerals Ltd. There were signs that international hot money has started to leave China. Surveys indicate that new Chinese parents are shunning foreign baby-care products.

THE ANALYSIS OF THE ART MARKET FROM REPUBLIC OF MOLDOVA WITH INNOVATIVE MARKETING ELEMENTS (based on the author's interview

Directory of Open Access Journals (Sweden)

Olga PERCINSCHI

2015-04-01

Full Text Available The actuality of this research consists in the less developed of art market in the Republic of Moldova and lack of researches in this domain. The goal of the article is to analyze the art market of the Republic of Moldova with innovative marketing elements. The method of this article is based on interviews conducted with painters, owners of art galleries, art salons were highlighted barriers that hinder the development of the art market in Moldova. The main results are identified ways to overcome and directions for the development of effective marketing that will enhance the country's competitiveness as a whole.

76 FR 10555 - Marketing Orders for Nectarines and Peaches Grown in California; Notice of Request for New...

Science.gov (United States)

2011-02-25

... California; Notice of Request for New Information Collection AGENCY: Agricultural Marketing Service, USDA... request approval for new forms to be used to collect information related to Federal marketing orders for... to be assured of consideration. Additional Information: Contact Andrew Hatch, Supervisory Marketing...

Study of network resource allocation based on market and game theoretic mechanism

Science.gov (United States)

Liu, Yingmei; Wang, Hongwei; Wang, Gang

2004-04-01

We work on the network resource allocation issue concerning network management system function based on market-oriented mechanism. The scheme is to model the telecommunication network resources as trading goods in which the various network components could be owned by different competitive, real-world entities. This is a multidisciplinary framework concentrating on the similarity between resource allocation in network environment and the market mechanism in economic theory. By taking an economic (market-based and game theoretic) approach in routing of communication network, we study the dynamic behavior under game-theoretic framework in allocating network resources. Based on the prior work of Gibney and Jennings, we apply concepts of utility and fitness to the market mechanism with an intention to close the gap between experiment environment and real world situation.

Riverine based eco-tourism: Trinity River non-market benefits estimates

Science.gov (United States)

Douglas, A.J.; Taylor, J.G.

1998-01-01

California's Central Valley Project (CVP) was approved by voters in a statewide referendum in 1933. CVP referendum approval initiated funding for construction of important water development projects that had far reaching effects on regional water supplies. The construction of Trinity Dam in 1963 and the subsequent transbasin diversion of Trinity River flow was one of several CVP projects that had noteworthy adverse environmental and regional economic impacts. The Trinity River is the largest tributary of the Klamath River, and has its headwaters in the Trinity Alps of north-central California. After the construction of Trinity Dam in 1963, 90% of the Trinity River flow at Lewiston was moved to the Sacramento River via the Clear Creek Tunnel. Before 1963, the Trinity River was a major recreation resource of Northern California. The loss of streamflow has had a marked adverse impact on Trinity River-related recreation activities and the size and robustness of Trinity River salmon, steelhead, shad, and sturgeon runs. Trinity River water produces hydropower during its transit via Bureau of Reclamation canals and pumps to the northern San Joaquin Valley, where it is used for irrigated agriculture. The benefits provided by Trinity River instream flow-related environmental amenities were estimated with the travel cost method (TCM). Trinity River non-market benefits are about $406 million per annum, while the social cost of sending water down the Trinity River ranges from $17 to $42 million per annum, depending on the exact flow. We also discuss the relative magnitude of Trinity River survey data contingent value method (CVM) benefits estimates.

Illicit online marketing of lorcaserin before DEA scheduling.

Science.gov (United States)

Liang, Bryan A; Mackey, Tim K; Archer-Hayes, Ashley N; Shinn, Linda M

2013-05-01

Antiobesity drugs have been marketed illicitly by "no prescription" online pharmacies after approval and scheduling by the drug enforcement agency. We assess whether antiobesity drug Belviq® (lorcaserin HCl) was available from illicit online vendors before DEA-scheduling when sales are unauthorized. Online searches of "buy Belviq no prescription" examining first five result pages marketing the drug. Searches were performed from 11/5/2012-12/8/2012, prior to DEA scheduing. Belviq® is actively marketed by "no prescription" online vendors despite official unavailability and prescription requirements. Approaches included direct-to-consumer advertising using descriptive website URLs; linking to illicit marketers; and directing customers to other weight-loss websites for additional marketing. Finally, large quantities were marketed by business-to-business vendors. Illicit online "no prescription" pharmacies are marketing unauthorized, suspect antiobesity drugs before DEA scheduling and permitted marketing. Regulators must legally intercede to ensure patient safety, and providers must educate patients about online-sourcing risks. Copyright © 2013 The Obesity Society.

78 FR 52129 - Cotton Classification and Market News Service: Notice of Request for an Extension and Revision of...

Science.gov (United States)

2013-08-22

... DEPARTMENT OF AGRICULTURE Agricultural Marketing Service [AMS-CN-13-0045] Cotton Classification... Information Collection AGENCY: Agricultural Marketing Service, USDA. ACTION: Notice and request for comments... announces the Agricultural Marketing Service's (AMS) intention to request approval from the Office of...

Market Segmentation in Business Technology Base: The Case of Segmentation of Sparkling

Directory of Open Access Journals (Sweden)

Valéria Riscarolli

2014-08-01

Full Text Available A common market segmentation premise for products and services rules consumer behavior as the segmentation center piece. Would this be the logic for segmentation used by small technology based companies? In this article we target at determining the principles of market segmentation used by a vitiwinery company, as research object. This company is recognized by its products excellence, either in domestic as well as in the foreign market, among 13 distinct countries. The research method used is a case study, through information from the company’s CEOs and crossed by primary information from observation and formal registries and documents of the company. In this research we look at sparkling wines market segmentation. Main results indicate that the winery studied considers only technological elements as the basis to build a market segment. One may conclude that a market segmentation for this company is based upon technological dominion of sparkling wines production, aligned with a premium-price policy. In the company, directorship believes that as sparkling wines market is still incipient in the country, sparkling wine market segments will form and consolidate after the evolution of consumers tasting preferences, depending on technologies that boost sparkling wines quality. 

A valuation-Based Test of Market Timing

NARCIS (Netherlands)

Koeter-Kant, J.; Elliott, W.B.; Warr, R.S.

2007-01-01

We implement an earnings-based fundamental valuation model to test the impact of market timing on the firm's method of funding the financing deficit. We argue that our valuation metric provides a superior measure of equity misvaluation because it avoids multiple interpretation problems faced by the

Agent-based simulation of electricity markets. A literature review

Energy Technology Data Exchange (ETDEWEB)

Sensfuss, F.; Ragwitz, M. [Fraunhofer-Institut fuer Systemtechnik und Innovationsforschung (ISI), Karlsruhe (Germany); Genoese, M.; Moest, D. [Karlsruhe Univ. (T.H.) (Germany). Inst. fuer Industriebetriebslehre und Industrielle Produktion

2007-07-01

Liberalisation, climate policy and promotion of renewable energy are challenges to players of the electricity sector in many countries. Policy makers have to con-sider issues like market power, bounded rationality of players and the appear-ance of fluctuating energy sources in order to provide adequate legislation. Fur-thermore the interactions between markets and environmental policy instru-ments become an issue of increasing importance. A promising approach for the scientific analysis of these developments is the field of agent-based simulation. The goal of this article is to provide an overview of the current work applying this methodology to the analysis of electricity markets. (orig.)

Planning operations before market launch for balancing time-to-market and risks in pharmaceutical supply chains

DEFF Research Database (Denmark)

Hansen, Klaus Reinholdt Nyhuus; Grunow, Martin

2015-01-01

Shorter product life cycles and the resulting increase in new product introductions boost the importance of product launch operations. In the pharmaceutical sector, product launch operations are of particular importance, as companies seek to reduce time-to-market to better exploit patent protection....... Large volumes of product need to be ready to fill the downstream supply chain immediately at market launch. Building up the required inventory is, however, connected to several risks. In addition to the risk associated with the lack of demand information for a new product, there are several risks unique...... to the pharmaceutical sector. After approval by central authorities such as the FDA or EMA, a new drug still needs to receive market authorization, which is in most cases granted by some local authorities – in Europe, for example, by more than 30 national and regional bodies. The duration of these different market...

Market-based transmission expansion planning by improved differential evolution

International Nuclear Information System (INIS)

Georgilakis, Pavlos S.

2010-01-01

The restructuring and deregulation has exposed the transmission planner to new objectives and uncertainties. As a result, new criteria and approaches are needed for transmission expansion planning (TEP) in deregulated electricity markets. This paper proposes a new market-based approach for TEP. An improved differential evolution (IDE) model is proposed for the solution of this new market-based TEP problem. The modifications of IDE in comparison to the simple differential evolution method are: (1) the scaling factor F is varied randomly within some range, (2) an auxiliary set is employed to enhance the diversity of the population, (3) the newly generated trial vector is compared with the nearest parent, and (4) the simple feasibility rule is used to treat the constraints. Results from the application of the proposed method on the IEEE 30-bus test system demonstrate the feasibility and practicality of the proposed IDE for the solution of TEP problem. (author)

Mass market development strategies of software industries: Case study based research

Directory of Open Access Journals (Sweden)

Varun Gupta

2016-09-01

Full Text Available The success in competitive mass market software development depends on the quality of software development and market segments targeted. Market segments are categorized by uncertainties contributed by “Newness” and “turbulences”, making the software success stochastic in nature. Selecting good market segments, delivering high quality software versions in the lowest time than competitors, result in increasing demand in markets and ultimately revenues. Enhanced customer base is beneficial for current product as well as for future products of industry in the form of increased reputation and increased involvement of customers in future development. The case study was conducted with 13 representatives drawing experiences of 14 mass market projects. Results indicate that software solutions are delivered to few investors or in highly competitive markets, as per the survey's findings of the marketing departments. The software organizations are reluctant to deliver relatively complex solutions in new markets unless and until strongly convinced with the probable success. The method for selection of market segments belonging to new and existing markets for undertaking the software delivery is also proposed in this paper. The model will help software industry decide the market segments and high abstract level features that could increase probability of software success. Poor selection of markets or targeting markets of “improper” size affects the market share of the industry to a great extend.

Where do Electronic Markets Come From?

DEFF Research Database (Denmark)

Castelle, Michael; Millo, Yuval; Beunza, Daniel

2016-01-01

of automated markets was produced through an interweaving of both technological and political change. This processual redefinition of the ‘exchange’, in addition, may provide a suggestive precedent for understanding contemporary regulatory crises generated by other digital marketplace platforms.......The practices of high-frequency trading (HFT) are dependent on automated financial markets, especially those produced by securities exchanges electronically interconnected with competing exchanges. How did this infrastructural and organizational state of affairs come to be? Employing the conceptual...... distinction between fixed-role and switch-role markets, we analyse the discourse surrounding the design and eventual approval of the Securities and Exchange Commission’s Regulation of Exchanges and Alternative Trading Systems (Reg ATS). We find that the disruption of the exchange industry at the hands...

Marketing Need-Based Financial Aid Programs: An Institutional Case Study

Science.gov (United States)

Knight, Mary Beth

2010-01-01

Colleges and universities represent one of the most utilized sources of need-based financial aid information for students and families, and yet most research in access marketing is focused at the national and state levels. There is sparse published information about the effects of financial aid marketing observed through quantitative analysis, in…

Promoting physical activity among youth through community-based prevention marketing.

Science.gov (United States)

Bryant, Carol A; Courtney, Anita H; McDermott, Robert J; Alfonso, Moya L; Baldwin, Julie A; Nickelson, Jen; McCormack Brown, Kelli R; Debate, Rita D; Phillips, Leah M; Thompson, Zachary; Zhu, Yiliang

2010-05-01

Community-based prevention marketing (CBPM) is a program planning framework that blends community-organizing principles with a social marketing mind-set to design, implement, and evaluate public health interventions. A community coalition used CBPM to create a physical activity promotion program for tweens (youth 9-13 years of age) called VERB Summer Scorecard. Based on the national VERB media campaign, the program offered opportunities for tweens to try new types of physical activity during the summer months. The VERB Summer Scorecard was implemented and monitored between 2004 and 2007 using the 9-step CBPM framework. Program performance was assessed through in-depth interviews and a school-based survey of youth. The CBPM process and principles used by school and community personnel to promote physical activity among tweens are presented. Observed declines may become less steep if school officials adopt a marketing mind-set to encourage youth physical activity: deemphasizing health benefits but promoting activity as something fun that fosters spending time with friends while trying and mastering new skills. Community-based programs can augment and provide continuity to school-based prevention programs to increase physical activity among tweens.

From physical marketing to web marketing

NARCIS (Netherlands)

Constantinides, Efthymios

2002-01-01

Reviews the criticism of the 4P marketing mix framework as the basis of traditional and virtual marketing planning. Argues that the customary marketing management approach, based on the popular marketing mix 4Ps paradigm, is inadequate in the case of virtual marketing. Identifies two main

Marketing wholesale electricity in British Columbia

Energy Technology Data Exchange (ETDEWEB)

Moghadam, B. [Powerex, Vancouver, BC (Canada)

2002-03-14

An open access wholesale transmission tariff (WTS) has been in place in British Columbia since 1997, and wholesale electricity can be sold to wholesale purchasers by independent producers located within the province. Customers range from municipalities to British Columbia Hydro (BC Hydro), to Powerex, to UtiliCorp Networks Corporation (UNC). Provided that the necessary approvals and transmission services have been acquired, the energy may be transmitted anywhere in Canada or the United States. The generation and sale of electricity within British Columbia and the United States is subject to government and regulatory approvals. Several buyers and sellers that come together to trade a product are part of a hub. The largest such hub in the Pacific Northwest is called the Mid-Columbia (Mid-C) hub in Washington. The commodity is traded in 25 MW standard blocks. The credit requirements of the purchaser must be satisfied by the generating party. BC Hydro wholesale transmission service can be purchased by any wholesale power marketer or generator to transmit the power to market. It is imperative that scheduling personnel be available at all times. The Western System Coordinating Council (WSCC) insists that an operating reserve of 5 per cent hydro generation and 7 per cent thermal generation to support the electrical system in the face of an emergency be available for the electricity marketed through the hub. Powerex has been successful since 1988 in the marketing of electricity throughout the WSCC. An example was provided to help make the rules a bit easier to comprehend. refs.

Marketing wholesale electricity in British Columbia

International Nuclear Information System (INIS)

Moghadam, B.

2002-01-01

An open access wholesale transmission tariff (WTS) has been in place in British Columbia since 1997, and wholesale electricity can be sold to wholesale purchasers by independent producers located within the province. Customers range from municipalities to British Columbia Hydro (BC Hydro), to Powerex, to UtiliCorp Networks Corporation (UNC). Provided that the necessary approvals and transmission services have been acquired, the energy may be transmitted anywhere in Canada or the United States. The generation and sale of electricity within British Columbia and the United States is subject to government and regulatory approvals. Several buyers and sellers that come together to trade a product are part of a hub. The largest such hub in the Pacific Northwest is called the Mid-Columbia (Mid-C) hub in Washington. The commodity is traded in 25 MW standard blocks. The credit requirements of the purchaser must be satisfied by the generating party. BC Hydro wholesale transmission service can be purchased by any wholesale power marketer or generator to transmit the power to market. It is imperative that scheduling personnel be available at all times. The Western System Coordinating Council (WSCC) insists that an operating reserve of 5 per cent hydro generation and 7 per cent thermal generation to support the electrical system in the face of an emergency be available for the electricity marketed through the hub. Powerex has been successful since 1988 in the marketing of electricity throughout the WSCC. An example was provided to help make the rules a bit easier to comprehend. refs

A Computational Agent-Based Modeling Approach for Competitive Wireless Service Market

KAUST Repository

Douglas, C C; Hyoseop Lee,; Wonsuck Lee,

2011-01-01

Using an agent-based modeling method, we study market dynamism with regard to wireless cellular services that are in competition for a greater market share and profit. In the proposed model, service providers and consumers are described as agents

Agent-based models of financial markets

Energy Technology Data Exchange (ETDEWEB)

Samanidou, E [Department of Economics, University of Kiel, Olshausenstrasse 40, D-24118 Kiel (Germany); Zschischang, E [HSH Nord Bank, Portfolio Mngmt. and Inv., Martensdamm 6, D-24103 Kiel (Germany); Stauffer, D [Institute for Theoretical Physics, Cologne University, D-50923 Koeln (Germany); Lux, T [Department of Economics, University of Kiel, Olshausenstrasse 40, D-24118 Kiel (Germany)

2007-03-15

This review deals with several microscopic ('agent-based') models of financial markets which have been studied by economists and physicists over the last decade: Kim-Markowitz, Levy-Levy-Solomon, Cont-Bouchaud, Solomon-Weisbuch, Lux-Marchesi, Donangelo-Sneppen and Solomon-Levy-Huang. After an overview of simulation approaches in financial economics, we first give a summary of the Donangelo-Sneppen model of monetary exchange and compare it with related models in economics literature. Our selective review then outlines the main ingredients of some influential early models of multi-agent dynamics in financial markets (Kim-Markowitz, Levy-Levy-Solomon). As will be seen, these contributions draw their inspiration from the complex appearance of investors' interactions in real-life markets. Their main aim is to reproduce (and, thereby, provide possible explanations) for the spectacular bubbles and crashes seen in certain historical episodes, but they lack (like almost all the work before 1998 or so) a perspective in terms of the universal statistical features of financial time series. In fact, awareness of a set of such regularities (power-law tails of the distribution of returns, temporal scaling of volatility) only gradually appeared over the nineties. With the more precise description of the formerly relatively vague characteristics (e.g. moving from the notion of fat tails to the more concrete one of a power law with index around three), it became clear that financial market dynamics give rise to some kind of universal scaling law. Showing similarities with scaling laws for other systems with many interacting sub-units, an exploration of financial markets as multi-agent systems appeared to be a natural consequence. This topic has been pursued by quite a number of contributions appearing in both the physics and economics literature since the late nineties. From the wealth of different flavours of multi-agent models that have appeared up to now, we

Agent-based models of financial markets

Science.gov (United States)

Samanidou, E.; Zschischang, E.; Stauffer, D.; Lux, T.

2007-03-01

This review deals with several microscopic ('agent-based') models of financial markets which have been studied by economists and physicists over the last decade: Kim-Markowitz, Levy-Levy-Solomon, Cont-Bouchaud, Solomon-Weisbuch, Lux-Marchesi, Donangelo-Sneppen and Solomon-Levy-Huang. After an overview of simulation approaches in financial economics, we first give a summary of the Donangelo-Sneppen model of monetary exchange and compare it with related models in economics literature. Our selective review then outlines the main ingredients of some influential early models of multi-agent dynamics in financial markets (Kim-Markowitz, Levy-Levy-Solomon). As will be seen, these contributions draw their inspiration from the complex appearance of investors' interactions in real-life markets. Their main aim is to reproduce (and, thereby, provide possible explanations) for the spectacular bubbles and crashes seen in certain historical episodes, but they lack (like almost all the work before 1998 or so) a perspective in terms of the universal statistical features of financial time series. In fact, awareness of a set of such regularities (power-law tails of the distribution of returns, temporal scaling of volatility) only gradually appeared over the nineties. With the more precise description of the formerly relatively vague characteristics (e.g. moving from the notion of fat tails to the more concrete one of a power law with index around three), it became clear that financial market dynamics give rise to some kind of universal scaling law. Showing similarities with scaling laws for other systems with many interacting sub-units, an exploration of financial markets as multi-agent systems appeared to be a natural consequence. This topic has been pursued by quite a number of contributions appearing in both the physics and economics literature since the late nineties. From the wealth of different flavours of multi-agent models that have appeared up to now, we discuss the Cont

Agent-based models of financial markets

International Nuclear Information System (INIS)

Samanidou, E; Zschischang, E; Stauffer, D; Lux, T

2007-01-01

This review deals with several microscopic ('agent-based') models of financial markets which have been studied by economists and physicists over the last decade: Kim-Markowitz, Levy-Levy-Solomon, Cont-Bouchaud, Solomon-Weisbuch, Lux-Marchesi, Donangelo-Sneppen and Solomon-Levy-Huang. After an overview of simulation approaches in financial economics, we first give a summary of the Donangelo-Sneppen model of monetary exchange and compare it with related models in economics literature. Our selective review then outlines the main ingredients of some influential early models of multi-agent dynamics in financial markets (Kim-Markowitz, Levy-Levy-Solomon). As will be seen, these contributions draw their inspiration from the complex appearance of investors' interactions in real-life markets. Their main aim is to reproduce (and, thereby, provide possible explanations) for the spectacular bubbles and crashes seen in certain historical episodes, but they lack (like almost all the work before 1998 or so) a perspective in terms of the universal statistical features of financial time series. In fact, awareness of a set of such regularities (power-law tails of the distribution of returns, temporal scaling of volatility) only gradually appeared over the nineties. With the more precise description of the formerly relatively vague characteristics (e.g. moving from the notion of fat tails to the more concrete one of a power law with index around three), it became clear that financial market dynamics give rise to some kind of universal scaling law. Showing similarities with scaling laws for other systems with many interacting sub-units, an exploration of financial markets as multi-agent systems appeared to be a natural consequence. This topic has been pursued by quite a number of contributions appearing in both the physics and economics literature since the late nineties. From the wealth of different flavours of multi-agent models that have appeared up to now, we discuss the Cont

The possibility of obtaining marketing authorization of orphan pharmaceutical compounding preparations: 3,4-DAP for Lambert-Eaton Myasthenic Syndrome.

Science.gov (United States)

de Wilde, Sofieke; de Jong, Maria G H; Lipka, Alexander F; Guchelaar, Henk-Jan; Schimmel, Kirsten J M

2018-03-01

Pharmaceutical compounding preparations, produced by (hospital) pharmacies, usually do not have marketing authorization. As a consequence, some of these pharmaceutical compounding preparations can be picked-up by a pharmaceutical company to obtain marketing authorization, often leading to price increases. An example is the 3,4-diaminopyridine slow release (3,4-DAP SR) tablets for Lambert-Eaton Myasthenic Syndrome (LEMS). In 2009 marketing authorization was given for the commercial immediate release phosphate salt of the drug, including a fifty-fold price increase compared to the pharmaceutical compounding preparation. Obtaining marketing authorization for 3,4-DAP SR by academia might have been a solution to prevent this price increase. To determine whether the available data of a pharmaceutical compounding preparation with long-term experience in regular care are adequate to obtain marketing authorization, 3,4-DAP SR is used as a case study. A retrospective qualitative case-study was performed. Initially, document analysis was executed by collecting the required data for marketing authorization in general and whether data of Firdapse® and 3,4-DAP SR met these requirements. Secondly, the (non-) available data of the two formulations were compared with each other to determine the differences in availability. At the time of approval, almost all data were available for both Firdapse® and 3,4-DAP SR. Conversely, much of the data used for the approval of Firdapse® originated from the 3,4-DAP immediate release (3,4-DAP IR) formulation. Only two bioequivalence studies and one pharmacology safety study was performed with Firdapse® before marketing authorization application. In conclusion, at time Firdapse® obtained approval, the data available did not differ substantially from 3,4-DAP SR, indicating that approval with 3,4-DAP SR would have been possible. We make a plea for approval of orphan medicinal products developed and manufactured by academic institutions as to

Development of educational Web-based simulator for the electricity spot market in Korea

International Nuclear Information System (INIS)

Lee, J.W.; Yang, K.M.; Jeong, Y.W.; Park, J.B.; Shin, J.R.

2006-01-01

Market simulation approaches are used frequently by electric utilities to resolve the spot market-related problems that are often encountered in competitive electricity markets. A well constructed market simulator offers the possibility to foresee the effect of new market structures or rules before they are actually implemented. This paper presented a newly developed educational market simulator that simulates the power exchange methods and market rules of the Two Way Bidding Pool (TWBP) in Korea. It allows users to set information related with market and market entities. In particular, it is an educational tool that enables interaction between lecturers and students via Web-based programs. Students can learn the effectiveness of an electricity spot market by bidding and examining the market with lecturers. Measures have been taken to address the problem of multi-users trying to manage the complex data sets. The developed application program is composed of 3 tiers where the middle tier is logically divided into 2 kinds of application programs. The divided application programs are interconnected by using the Web-service based on Extended Markup Technology and Hyper Text Transfer Protocol which make the distributed computing technology possible. Unlike most existing educational simulators, this one has the advantage of allowing students to make bids just like in a real market, thus showing them how the real electricity market runs and how market participants make their revenues. 10 refs., 4 tabs., 13 figs

Development of educational Web-based simulator for the electricity spot market in Korea

Energy Technology Data Exchange (ETDEWEB)

Lee, J.W.; Yang, K.M.; Jeong, Y.W.; Park, J.B.; Shin, J.R. [Konkuk Univ., Seoul (Korea, Republic of). Dept. of Electrical Engineering

2006-07-01

Market simulation approaches are used frequently by electric utilities to resolve the spot market-related problems that are often encountered in competitive electricity markets. A well constructed market simulator offers the possibility to foresee the effect of new market structures or rules before they are actually implemented. This paper presented a newly developed educational market simulator that simulates the power exchange methods and market rules of the Two Way Bidding Pool (TWBP) in Korea. It allows users to set information related with market and market entities. In particular, it is an educational tool that enables interaction between lecturers and students via Web-based programs. Students can learn the effectiveness of an electricity spot market by bidding and examining the market with lecturers. Measures have been taken to address the problem of multi-users trying to manage the complex data sets. The developed application program is composed of 3 tiers where the middle tier is logically divided into 2 kinds of application programs. The divided application programs are interconnected by using the Web-service based on Extended Markup Technology and Hyper Text Transfer Protocol which make the distributed computing technology possible. Unlike most existing educational simulators, this one has the advantage of allowing students to make bids just like in a real market, thus showing them how the real electricity market runs and how market participants make their revenues. 10 refs., 4 tabs., 13 figs.

An integrated ant colony optimization approach to compare strategies of clearing market in electricity markets. Agent-based simulation

International Nuclear Information System (INIS)

Azadeh, A.; Maleki-Shoja, B.; Skandari, M.R.

2010-01-01

In this paper, an innovative model of agent based simulation, based on Ant Colony Optimization (ACO) algorithm is proposed in order to compare three available strategies of clearing wholesale electricity markets, i.e. uniform, pay-as-bid, and generalized Vickrey rules. The supply side actors of the power market are modeled as adaptive agents who learn how to bid strategically to optimize their profit through indirect interaction with other actors of the market. The proposed model is proper for bidding functions with high number of dimensions and enables modelers to avoid curse of dimensionality as dimension grows. Test systems are then used to study the behavior of each pricing rule under different degrees of competition and heterogeneity. Finally, the pricing rules are comprehensively compared using different economic criteria such as average cleared price, efficiency of allocation, and price volatility. Also, principle component analysis (PCA) is used to rank and select the best price rule. To the knowledge of the authors, this is the first study that uses ACO for assessing strategies of wholesale electricity market. (author)

An agent-based analysis of the German electricity market with transmission capacity constraints

International Nuclear Information System (INIS)

Veit, Daniel J.; Weidlich, Anke; Krafft, Jacob A.

2009-01-01

While some agent-based models have been developed for analyzing the German electricity market, there has been little research done on the emerging issue of intra-German congestion and its effects on the bidding behavior of generator agents. Yet, studies of other markets have shown that transmission grid constraints considerably affect strategic behavior in electricity markets. In this paper, the implications of transmission constraints on power markets are analyzed for the case of Germany. Market splitting is applied in the case of congestion in the grid. For this purpose, the agent-based modeling of electricity systems (AMES) market package developed by Sun and Tesfatsion is modified to fit the German context, including a detailed representation of the German high-voltage grid and its interconnections. Implications of transmission constraints on prices and social welfare are analyzed for scenarios that include strategic behavior of market participants and high wind power generation. It can be shown that strategic behavior and transmission constraints are inter-related and may pose severe problems in the future German electricity market.

An agent-based analysis of the German electricity market with transmission capacity constraints

Energy Technology Data Exchange (ETDEWEB)

Veit, Daniel J.; Weidlich, Anke; Krafft, Jacob A. [University of Mannheim, Dieter Schwarz Chair of Business Administration, E-Business and E-Government, 68131 Mannheim (Germany)

2009-10-15

While some agent-based models have been developed for analyzing the German electricity market, there has been little research done on the emerging issue of intra-German congestion and its effects on the bidding behavior of generator agents. Yet, studies of other markets have shown that transmission grid constraints considerably affect strategic behavior in electricity markets. In this paper, the implications of transmission constraints on power markets are analyzed for the case of Germany. Market splitting is applied in the case of congestion in the grid. For this purpose, the agent-based modeling of electricity systems (AMES) market package developed by Sun and Tesfatsion is modified to fit the German context, including a detailed representation of the German high-voltage grid and its interconnections. Implications of transmission constraints on prices and social welfare are analyzed for scenarios that include strategic behavior of market participants and high wind power generation. It can be shown that strategic behavior and transmission constraints are inter-related and may pose severe problems in the future German electricity market. (author)

76 FR 51075 - Self-Regulatory Organizations; International Securities Exchange, LLC; Order Granting Approval to...

Science.gov (United States)

2011-08-17

... Organizations; International Securities Exchange, LLC; Order Granting Approval to a Proposed Rule Change Relating to Appointments to Competitive Market Makers August 11, 2011. I. Introduction On June 10, 2011, the International Securities Exchange, LLC (the ``Exchange'' or the ``ISE'') filed with the Securities...

75 FR 2915 - Self-Regulatory Organizations; International Securities Exchange, LLC; Order Approving a Proposed...

Science.gov (United States)

2010-01-19

... SECURITIES AND EXCHANGE COMMISSION [Release No. 34-61317; File No. SR-ISE-2009-103] Self-Regulatory Organizations; International Securities Exchange, LLC; Order Approving a Proposed Rule Change Relating to Market Data Fees January 8, 2010. I. Introduction On November 25, 2009, the International...

75 FR 1437 - Self-Regulatory Organizations; Chicago Board Options Exchange, Incorporated; Order Approving a...

Science.gov (United States)

2010-01-11

... SECURITIES AND EXCHANGE COMMISSION [Release No. 34-61274; File No. SR-CBOE-2009-089] Self-Regulatory Organizations; Chicago Board Options Exchange, Incorporated; Order Approving a Proposed Rule... announce to members via Regulatory Circular any determination regarding the routing of market stock-option...

Worldwide, 3-Year, Post-Marketing Surveillance Experience with Tofacitinib in Rheumatoid Arthritis.

Science.gov (United States)

Cohen, Stanley; Curtis, Jeffrey R; DeMasi, Ryan; Chen, Yan; Fan, Haiyun; Soonasra, Arif; Fleischmann, Roy

2018-06-01

Post-marketing surveillance (PMS) is an integral part of monitoring adverse events (AEs) following approval of new drugs. Tofacitinib is an oral Janus kinase inhibitor for the treatment of rheumatoid arthritis (RA). An analysis of PMS reports was conducted to evaluate the safety of tofacitinib in a post-marketing setting. Worldwide tofacitinib PMS data received in the Pfizer safety database from November 6, 2012 (first marketing authorization of tofacitinib) to November 5, 2015 were analyzed. Serious AEs (SAEs) of interest were reviewed and reporting rates (RRs) were calculated by dividing the number of SAEs by the estimated 100 patient-years of exposure. Patient exposure was calculated based on estimated worldwide sales and an estimated daily regimen of tofacitinib 5 mg twice daily. During the 3-year reporting period, worldwide post-marketing exposure to tofacitinib since approval was estimated to be 34,223 patient-years. In total, 9291 case reports (82.9% non-serious) were received and 25,417 AEs, 102 fatal cases, and 4352 SAEs were reported. The RRs (per 100 patient-years) for SAEs of interest by Medical Dictionary for Regulatory Activities System Organ Class were 2.57 for infections, 0.91 for gastrointestinal disorders, 0.60 for respiratory disorders, 0.45 for neoplasms, 0.43 for cardiac disorders, and 0.12 for hepatobiliary disorders. Although there are limitations to these data, no new safety risks were revealed in this real-world setting compared with the safety profile identified in the tofacitinib RA clinical development program. Any risks identified through the tofacitinib development program and PMS will continue to be monitored through pharmacovigilance surveillance. Pfizer Inc.

Implications for Utilizing YouTube based Community Interactions for Destination Marketing

OpenAIRE

Sambhanthan, Arunasalam; Thelijjagoda, Samantha; Tan, Joseph

2013-01-01

In recent time, YouTube has evolved into a powerful medium for social interaction. Utilizing YouTube for enhancing marketing endeavors is a strategy practiced by marketing professionals across several industries. This paper rationalizes on the different ways and means of leveraging YouTube-based platforms for effective destination marketing by the hospitality industry (hotels). More specifically, the typology of virtual communities is adapted to evaluate the YouTube platform for effective des...

Agent-based land markets: Heterogeneous agents, land proces and urban land use change

NARCIS (Netherlands)

Filatova, Tatiana; Parker, Dawn C.; van der Veen, A.; Amblard, F.

2007-01-01

We construct a spatially explicit agent-based model of a bilateral land market. Heterogeneous agents form their bid and ask prices for land based on the utility that they obtain from a certain location (houte/land) and base on the state of the market (an excess of demand or supply). We underline the

Distributed, price-based control approach to market-based operation of future power systems

NARCIS (Netherlands)

Jokic, A.; Bosch, van den P.P.J.; Hermans, R.M.

2009-01-01

In this paper we present, discuss and illustrate on examples the price-based control paradigm as a suitable approach to solve some of the challenging problems facing future, market-based power systems. It is illustrated how global objectives and constraints are optimally translated into time-varying

International market segmentation based on consumer-product relations

NARCIS (Netherlands)

ter Hofstede, F; Steenkamp, JBEM; Wedel, M

With increasing competition in the global marketplace, international segmentation has become an ever more important issue in developing, positioning, and selling products across national borders. The authors propose a methodology to identify cross-national market segments, based on means-end chain

Marketing Analysis and Strategy for a Small Business in the Beekeeping Industry.

Science.gov (United States)

1980-08-18

segment has opportunities associated with it that may be profitably 2Philip Kotler , " Marketing Management: Analysis, Planning, and Control," Prentice...I I I162 I I BIBLIOGRAPHY IB Abel, Derek and John Hammond. Strategic Market Planning. Englewood Cliffs, N.J.: Prentice- Hall, Inc., 1979. Kotler ...11I’ISTATIOY I I I I MARKETING ANALYSIS AND STRATEGY FOR A SMALL IBUSINESS IN THE BEEKEEPING INDUSTRY I III APPROVED: Acoession For DDC TABUn mounced or

Hospital Value-Based Purchasing Performance: Do Organizational and Market Characteristics Matter?

Science.gov (United States)

Spaulding, Aaron; Edwardson, Nick; Zhao, Mei

The hospital value-based purchasing (HVBP) program of the Centers for Medicare & Medicaid Services challenges hospitals to deliver high-quality care or face a reduction in Medicare payments. How do different organizational structures and market characteristics enable or inhibit successful transition to this new model of value-based care? To address that question, this study employs an institutional theory lens to test whether certain organizational structures and market characteristics mediate hospitals' ability to perform across HVBP domains.Data from the 2014 American Hospital Association Annual Survey Database, Area Health Resource File, the Medicare Hospital Compare Database, and the association between external environment and hospital performance are assessed through multiple regression analysis. Results indicate that hospitals that belong to a system are more likely than independent hospitals to score highly on the domains associated with the HVBP incentive arrangement. However, varying and sometimes counterintuitive market influences bring different dimensions to the HVBP program. A hospital's ability to score well in this new value arrangement may be heavily based on the organization's ability to learn from others, implement change, and apply the appropriate amount of control in various markets.

77 FR 53059 - Risk-Based Capital Guidelines: Market Risk

Science.gov (United States)

2012-08-30

...'' framework that includes (1) Risk-based capital requirements for credit risk, market risk, and operational... default and credit quality migration risk for non-securitization credit products. With respect to... securitization positions, the revisions assign a specific risk- weighting factor based on the credit rating of a...

13 CFR 108.470 - SBA approval of merger, consolidation, or reorganization of NMVC Company.

Science.gov (United States)

2010-01-01

... BUSINESS ADMINISTRATION NEW MARKETS VENTURE CAPITAL (âNMVCâ) PROGRAM Changes in Ownership, Structure, or Control Change in Structure of Nmvc Company § 108.470 SBA approval of merger, consolidation, or reorganization of NMVC Company. You may not merge, consolidate, change form of organization (corporation or...

78 FR 38070 - 30-Day Notice of Proposed Information Collection: Affirmative Fair Housing Marketing (AFHM) Plan

Science.gov (United States)

2013-06-25

... Information Collection: Affirmative Fair Housing Marketing (AFHM) Plan AGENCY: Office of the Chief Information Officer, HUD. ACTION: Notice. SUMMARY: HUD has submitted the proposed information collection requirement... Title of Information Collection: Affirmative Fair Housing Marketing (AFHM) Plan. OMB Approval Number...

MARKET SIGNALS IN VALUE-BASED PRICING PREMIUMS AND DISCOUNTS

OpenAIRE

Feuz, Dillon M.

1999-01-01

There is concern in the beef industry that present marketing practices may be impending the transmission of economic signals from consumers to producers. Presently, fed cattle may be sold on a show list, pen-by-pen, or on an individual head basis, and may be priced using live weight, dressed weight, or grid or formula pricing. Market signals are more likely to reach producers if cattle are priced individually. Current value-based pricing are discussed. Three grid pricing systems are evaluated...

Marketing evidence-based practice: what a CROC™!

Science.gov (United States)

Boyington, Alice R; Ferrall, Sheila M; Sylvanus, Terry

2010-10-01

Nurses should be engaged in evidence-based practice (EBP) to ensure that nursing care is efficient and effective. This article describes one cancer center's use of the Marketing Mix framework to educate staff nurses with the CROC™: Clinging Rigidly to Outdated Care campaign. As a result of the campaign, five EBP projects have been initiated in the cancer center.

Android Based Binus Profile Applications as the Marketing Tools of Bina Nusantara University

Science.gov (United States)

Iskandar, Karto

2014-03-01

Smart phones with apps in it is not a new phenomenon. Both of technologies have been fused with the lifestyle today. The ease and speed of access to information makes a lot of companies use it in the process of marketing a product to the public. Objective of this action is to win the competition that more competitive. The purpose of this research is to create mobile application android based to assist in the marketing and introduction Bina Nusantara University profile to prospective students. This research method using software engineering waterfall model to produce Android-based mobile applications. The results in the form of Android-based mobile application that can be used as a viral marketing tool for Bina Nusantara University. At the end of this study can be generated that mobile technology can be used as a media for effective marketing and branding, especially for Bina Nusantara University. Android technology based for marketing applications suited to the Bina Nusantara University applicant segment which are generally young people. The future along with the improvement of network quality and affordable cost, then the application can be made online, so features such as chat, maps, and other can be used optimally.

GUERRILLA MARKETING : A creative marketing method for start-ups

OpenAIRE

Zujewska, Barbara

2014-01-01

The objective of this thesis work was to introduce guerrilla marketing as a valuable marketing method for small and medium size startup companies. The thesis presents the theoretical studies on the subject based on literature and case studies. The practical use of the theory is demonstrated in the marketing plan based on guerrilla marketing approach. The marketing plan was written based on the example of an existing startup company, mCASH. The company is located in Oslo, Norway. The thesis...

[Industry regulation and its relationship to the rapid marketing of medical devices].

Science.gov (United States)

Matsuoka, Atsuko

2012-01-01

In the market of medical devices, non-Japanese products hold a large part even in Japan. To overcome this situation, the Japanese government has been announcing policies to encourage the medical devices industry, such as the 5-year strategy for medical innovation (June 6, 2012). The Division of Medical Devices has been contributing to rapid marketing of medical devices by working out the standards for approval review and accreditation of medical devices, guidances on evaluation of medical devices with emerging technology, and test methods for biological safety evaluation of medical devices, as a part of practice in the field of regulatory science. The recent outcomes are 822 standards of accreditation for Class II medical devices, 14 guidances on safety evaluation of medical devices with emerging technology, and the revised test methods for biological safety evaluation (MHLW Notification by Director, OMDE, Yakushokuki-hatsu 0301 No. 20 "Basic Principles of Biological Safety Evaluation Required for Application for Approval to Market Medical Devices").

The measurement of China's consumer market development based on CPI data

Science.gov (United States)

Xiao, Jiang; Wang, Minggang; Tian, Lixin; Zhen, Zaili

2018-01-01

Consumer Price Index (CPI) is a comprehensive index which contains a large amount of market information. In order to effectively measure the running status of China's consumer market and analyze the dynamic evolution characteristics of regional economic consumption in China, the eigenvalues and eigenvectors of random matrix are proposed to quantitatively describe the evolution relationship of provincial and regional CPI in China. Based on the provincial data of China's CPI, system risk entropy, synchronicity ratio, stability and market induction are introduced to characterize the market evolution characteristics, and analyze the regional differences and synchronicity of the consumer price index of China and evaluate the development of China's consumer market. The results show that the average system risk entropy of China's consumer market for the period 2000-2015 is 0.1646, fluctuating in the range of 0.0512-0.3288, indicating a higher system risk of China's consumer market. The system risk of China's consumer market is still higher than the average in nearly 15 years. Fluctuating in the range of 0.3871-0.9355, the market synchronicity ratio has a mean of 0.7225, which reveals a higher market consistency level, a rising trend in fluctuation but an increasing tendency in the degree of unbalanced regional development. Evolution results of market induction demonstrate that the evolution of China's consumer market has experienced four stages. The market induction has possessed a sustained growth trend since August 2010. Scenario analysis indicates that the key to effectively improve China's consumer market system is to solve the lagging issue of China's western region market on the basis of controlling and resolving of the existing risk.

Market Segmentation Using Bayesian Model Based Clustering

NARCIS (Netherlands)

Van Hattum, P.

2009-01-01

This dissertation deals with two basic problems in marketing, that are market segmentation, which is the grouping of persons who share common aspects, and market targeting, which is focusing your marketing efforts on one or more attractive market segments. For the grouping of persons who share

Benefiting from Customer and Competitor Knowledge: A Market-Based Approach to Organizational Learning

Science.gov (United States)

Hoe, Siu Loon

2008-01-01

Purpose: The purpose of this paper is to review the organizational learning, market orientation and learning orientation concepts, highlight the importance of market knowledge to organizational learning and recommend ways in adopting a market-based approach to organizational learning. Design/methodology/approach: The extant organizational learning…

The Simulation of Financial Markets by Agent-Based Mix-Game Models

OpenAIRE

Chengling Gou

2006-01-01

This paper studies the simulation of financial markets using an agent-based mix-game model which is a variant of the minority game (MG). It specifies the spectra of parameters of mix-game models that fit financial markets by investigating the dynamic behaviors of mix-game models under a wide range of parameters. The main findings are (a) in order to approach efficiency, agents in a real financial market must be heterogeneous, boundedly rational and subject to asymmetric information; (b) an ac...

Evidence-Based Theory of Market Manipulation And Application: The Malaysian Case

OpenAIRE

Heong, Yin Yun

2010-01-01

According to Part IX Division 1 in Securities Industry Act 1983 of Malaysia Law, stock market manipulation is defined as unlawful action taken either direct or indirectly by any person, to affect the price of securities of the corporation on a stock market in Malaysia for the purpose which may include the purpose of inducing other persons. Extending the framework of Allen and Gale (1992), the Author presents a theory based on the empirical evidence from prosecuted stock market manipulation ca...

77 FR 50191 - Self-Regulatory Organizations; The NASDAQ Stock Market LLC; Order Instituting Proceedings To...

Science.gov (United States)

2012-08-20

...-Regulatory Organizations; The NASDAQ Stock Market LLC; Order Instituting Proceedings To Determine Whether To Approve or Disapprove Proposed Rule Change To Establish ``Benchmark Orders'' Under NASDAQ Rule 4751(f) August 14, 2012. I. Introduction On May 1, 2012, The NASDAQ Stock Market LLC (``NASDAQ'' or ``Exchange...

77 FR 2265 - Request for Extension and Revision of a Currently Approved Information Collection

Science.gov (United States)

2012-01-17

... extension of and revision to a currently approved information collection of a voluntary customer survey... States Grain Standards Act and the Agricultural Marketing Act of 1946. This voluntary survey gives customers that are primarily in the grain, oilseed, rice, lentil, dry pea, edible bean, and related...

7 CFR 1484.30 - How does FAS formalize its working relationship with approved Cooperators?

Science.gov (United States)

2010-01-01

... 7 Agriculture 10 2010-01-01 2010-01-01 false How does FAS formalize its working relationship with... FAS formalize its working relationship with approved Cooperators? FAS will notify each applicant in... sign the program agreement and submit the signed agreement to the Director, Marketing Operations Staff...

Buying on margin, selling short in an agent-based market model

Science.gov (United States)

Zhang, Ting; Li, Honggang

2013-09-01

Credit trading, or leverage trading, which includes buying on margin and selling short, plays an important role in financial markets, where agents tend to increase their leverages for increased profits. This paper presents an agent-based asset market model to study the effect of the permissive leverage level on traders’ wealth and overall market indicators. In this model, heterogeneous agents can assume fundamental value-converging expectations or trend-persistence expectations, and their effective demands of assets depend both on demand willingness and wealth constraints, where leverage can relieve the wealth constraints to some extent. The asset market price is determined by a market maker, who watches the market excess demand, and is influenced by noise factors. By simulations, we examine market results for different leverage ratios. At the individual level, we focus on how the leverage ratio influences agents’ wealth accumulation. At the market level, we focus on how the leverage ratio influences changes in the asset price, volatility, and trading volume. Qualitatively, our model provides some meaningful results supported by empirical facts. More importantly, we find a continuous phase transition as we increase the leverage threshold, which may provide a further prospective of credit trading.

Some design lessons from market-based greenhouse gas regulation in the restructured Australian electricity industry

International Nuclear Information System (INIS)

MacGill, Iain; Outhred, Hugh; Nolles, Karel

2006-01-01

There is growing worldwide interest in the use of market-based policy instruments for climate change regulation in the electricity sector. These mechanisms would seem to offer some efficiency and flexibility advantages over more traditional regulatory approaches, while being highly compatible with competitive market-based electricity industries. Australia has been an early and enthusiastic adopter of both electricity industry restructuring and market-based environmental instruments. This paper first outlines some of these recent policy developments. In particular, we describe the objectives, design and outcomes to date of electricity industry restructuring, the Mandatory Renewable Energy Target, the NSW Greenhouse Benchmarks, the Queensland 13% Gas scheme and Government accredited Green Power. From this, we draw some key design lessons for such market-based instruments. These include the perils of abstraction in scheme design, the vital importance of setting appropriate baselines in 'baseline and credit' schemes, the possibility that such measures may interact in ways that reduce their environmental effectiveness, 'market for lemon' risks with tradable instruments that have measurement, verification or 'additionality' difficulties, and the challenges of creating transparent liquid markets for these mechanisms. The mixed performance of these Australian schemes to date illustrates the need for great care in designing such market-based approaches

Some design lessons from market-based greenhouse gas regulation in the restructured Australian electricity industry

Energy Technology Data Exchange (ETDEWEB)

MacGill, Iain [School of Electrical Engineering and Telecommunications, University of New South Wales, Sydney NSW 2052 (Australia)] e-mail: i.macgill@unsw.edu.au; Outhred, Hugh [School of Electrical Engineering and Telecommunications, University of New South Wales, Sydney NSW 2052 (Australia); Nolles, Karel [School of Electrical Engineering and Telecommunications, University of New South Wales, Sydney NSW 2052 (Australia)

2006-01-01

There is growing worldwide interest in the use of market-based policy instruments for climate change regulation in the electricity sector. These mechanisms would seem to offer some efficiency and flexibility advantages over more traditional regulatory approaches, while being highly compatible with competitive market-based electricity industries. Australia has been an early and enthusiastic adopter of both electricity industry restructuring and market-based environmental instruments. This paper first outlines some of these recent policy developments. In particular, we describe the objectives, design and outcomes to date of electricity industry restructuring, the Mandatory Renewable Energy Target, the NSW Greenhouse Benchmarks, the Queensland 13% Gas scheme and Government accredited Green Power. From this, we draw some key design lessons for such market-based instruments. These include the perils of abstraction in scheme design, the vital importance of setting appropriate baselines in 'baseline and credit' schemes, the possibility that such measures may interact in ways that reduce their environmental effectiveness, 'market for lemon' risks with tradable instruments that have measurement, verification or 'additionality' difficulties, and the challenges of creating transparent liquid markets for these mechanisms. The mixed performance of these Australian schemes to date illustrates the need for great care in designing such market-based approaches.

Some design lessons from market-based greenhouse gas regulation in the restructured Australian electricity industry

Energy Technology Data Exchange (ETDEWEB)

Iain MacGill; Hugh Outhred; Karel Nolles [University of New South Wales, Sydney, NSW (Australia). School of Electrical Engineering & Telecommunications

2006-01-01

There is growing worldwide interest in the use of market-based policy instruments for climate change regulation in the electricity sector. These mechanisms would seem to offer some efficiency and flexibility advantages over more traditional regulatory approaches, while being highly compatible with competitive market-based electricity industries. Australia has been an early and enthusiastic adopter of both electricity industry restructuring and market-based environmental instruments. This paper first outlines some of these recent policy developments. It then describes the objectives, design and outcomes to date of electricity industry restructuring, the Mandatory Renewable Energy Target, the NSW Greenhouse Benchmarks, the Queensland 13% Gas scheme and Government accredited Green Power. From this, some key design lessons are drawn for such market-based instruments. These include the perils of abstraction in scheme design, the vital importance of setting appropriate baselines in 'baseline and credit' schemes, the possibility that such measures may interact in ways that reduce their environmental effectiveness, 'market for lemon' risks with tradable instruments that have measurement, verification or 'additionality' difficulties, and the challenges of creating transparent liquid markets for these mechanisms. The mixed performance of these Australian schemes to date illustrates the need for great care in designing such market-based approaches. 36 refs., 2 figs.

A study of the spreading scheme for viral marketing based on a complex network model

Science.gov (United States)

Yang, Jianmei; Yao, Canzhong; Ma, Weicheng; Chen, Guanrong

2010-02-01

Buzzword-based viral marketing, known also as digital word-of-mouth marketing, is a marketing mode attached to some carriers on the Internet, which can rapidly copy marketing information at a low cost. Viral marketing actually uses a pre-existing social network where, however, the scale of the pre-existing network is believed to be so large and so random, so that its theoretical analysis is intractable and unmanageable. There are very few reports in the literature on how to design a spreading scheme for viral marketing on real social networks according to the traditional marketing theory or the relatively new network marketing theory. Complex network theory provides a new model for the study of large-scale complex systems, using the latest developments of graph theory and computing techniques. From this perspective, the present paper extends the complex network theory and modeling into the research of general viral marketing and develops a specific spreading scheme for viral marking and an approach to design the scheme based on a real complex network on the QQ instant messaging system. This approach is shown to be rather universal and can be further extended to the design of various spreading schemes for viral marketing based on different instant messaging systems.

[The Second Health Care Market: Market Mapping Based upon Consumer Perception].

Science.gov (United States)

Teichert, T; Mühlbach, C

2018-03-01

The aim of the study was to present a picture of consumers' views on the specific market of health and health products, the second German health market. Market analysis of the product categories was carried out. A large-scale representative survey (N=1 033) determined with an innovative adaptation of the repertory grid method the consumer's perspective on the specific market. Basic questions concerning attitudes to health as well as healthy behaviors completed the telephone survey. In the saturated markets, market for health is growing, especially in the context of aging societies, and this is not limited to primary medical products. In this study, product categories such as "dental care", "fruit and vegetables" or "nuts" were classified as healthy products. The relevance of health also in the macroeconomic context has been long underestimated. Health has still a high priority for consumers. A disclosure of individual perceptions in the health context provides a significantly more relevant product design. The identification of healthy product dimensions from the consumer's perspective sheds light on the actually desired product properties and the available potential to meet these desires. © Georg Thieme Verlag KG Stuttgart · New York.

E-Based Market Intelligence. A management information system for the market for energy-efficient buildings; E-Based Market Intelligence. Ein Managementinformationssystem zum Markt fuer energieeffizientes Bauen

Energy Technology Data Exchange (ETDEWEB)

Kaiser, Iris

2012-11-01

The dynamics of market trends is ever-increasing; in consequence, it is getting increasingly difficult to recognize market structures and forecast trends in the markets. Misinterpretations will often lead to wrong strategic decisions, and business chances will be lost if market potentials are not recognized. The publication uses the example of the market for energy-efficient buildings to show how market intellegence, i.e. relevant knowledge about markets, can be developed with free data obtained in the internet and used intelligently.

Research on Marketing Channel of Mobile Manufacturer Based on Analytic Hierarchy Process

Institute of Scientific and Technical Information of China (English)

XIONG Hui; LI Shi-ming; LAN Yong

2006-01-01

Research on "marketing channel" of mobile attracts much attention in these years,but there're only few articles referring to how to optimize the disposition of channel resources for mobile manufacturers. Based on a typically multiplex marketing channel system of mobile manufacturer, the analytic hierarchy process (AHP) structure model is established. Through the judgment matrix, simple and total hierarchy arrangement, consistent test, this paper gets the weight of each kind of marketing channel of mobile manufacturer. It provides the practical reference value for mobile manufacturers to distribute resources of marketing channels.

Prediction Markets and Beliefs about Climate: Results from Agent-Based Simulations

Science.gov (United States)

Gilligan, J. M.; John, N. J.; van der Linden, M.

2015-12-01

Climate scientists have long been frustrated by persistent doubts a large portion of the public expresses toward the scientific consensus about anthropogenic global warming. The political and ideological polarization of this doubt led Vandenbergh, Raimi, and Gilligan [1] to propose that prediction markets for climate change might influence the opinions of those who mistrust the scientific community but do trust the power of markets.We have developed an agent-based simulation of a climate prediction market in which traders buy and sell future contracts that will pay off at some future year with a value that depends on the global average temperature at that time. The traders form a heterogeneous population with different ideological positions, different beliefs about anthropogenic global warming, and different degrees of risk aversion. We also vary characteristics of the market, including the topology of social networks among the traders, the number of traders, and the completeness of the market. Traders adjust their beliefs about climate according to the gains and losses they and other traders in their social network experience. This model predicts that if global temperature is predominantly driven by greenhouse gas concentrations, prediction markets will cause traders' beliefs to converge toward correctly accepting anthropogenic warming as real. This convergence is largely independent of the structure of the market and the characteristics of the population of traders. However, it may take considerable time for beliefs to converge. Conversely, if temperature does not depend on greenhouse gases, the model predicts that traders' beliefs will not converge. We will discuss the policy-relevance of these results and more generally, the use of agent-based market simulations for policy analysis regarding climate change, seasonal agricultural weather forecasts, and other applications.[1] MP Vandenbergh, KT Raimi, & JM Gilligan. UCLA Law Rev. 61, 1962 (2014).

From physical marketing to web marketing

OpenAIRE

Constantinides, Efthymios

2002-01-01

Reviews the criticism of the 4P marketing mix framework as the basis of traditional and virtual marketing planning. Argues that the customary marketing management approach, based on the popular marketing mix 4Ps paradigm, is inadequate in the case of virtual marketing. Identifies two main limitations of the marketing mix when applied in online environments namely the role of the Ps in a virtual commercial setting and the lack of any strategic elements in the model. Identifies the critical fac...

U.S. Food and Drug Administration drug approval: slow advances in obstetric care in the United States.

Science.gov (United States)

Wing, Deborah A; Powers, Barbara; Hickok, Durlin

2010-04-01

The process for drug approval in the United States is complex and time-consuming. There are comparatively few drugs with U.S. Food and Drug Administration (FDA)-approved indications for obstetric use in this country at this time; however, several are under development. We review the process for drug approval and recount the approval histories of obstetric drugs reviewed in the recent past. We also outline the current status of two progestational agents that are under development. For a variety of reasons, including a small market compared with others such as cardiology or oncology, and the potential of being drawn into medical-legal litigation, sponsors are disinclined to pursue drug development for obstetric purposes in this country. We compare the procedures for review and approval of drugs in the United States with those in Europe, and note that recent changes within the FDA may result in not only more drugs being approved but also changes in labeling of already approved drugs. Special programs to facilitate drug development and reforms to modernize the process and improve safety are discussed. These may result in changes in labeling of already approved drugs. Obstacles such as funding and liability are also discussed.

Integration of new technology into clinical practice after FDA approval.

Science.gov (United States)

Govil, Ashul; Hao, Steven C

2016-10-01

Development of new medical technology is a crucial part of the advancement of medicine and our ability to better treat patients and their diseases. This process of development is long and arduous and requires a significant investment of human, financial and material capital. However, technology development can be rewarded richly by its impact on patient outcomes and successful sale of the product. One of the major regulatory hurdles to technology development is the Food and Drug Administration (FDA) approval process, which is necessary before a technology can be marketed and sold in the USA. Many businesses, medical providers and consumers believe that the FDA approval process is the only hurdle prior to use of the technology in day-to-day care. In order for the technology to be adopted into clinical use, reimbursement for both the device as well as the associated work performed by physicians and medical staff must be in place. Work and coverage decisions require Current Procedural Terminology (CPT) code development and Relative Value Scale Update Committee (RUC) valuation determination. Understanding these processes is crucial to the timely availability of new technology to patients and providers. Continued and better partnerships between physicians, industry, regulatory bodies and payers will facilitate bringing technology to market sooner and ensure appropriate utilization.

Green maritime transportation: Market based measures

DEFF Research Database (Denmark)

Psaraftis, Harilaos N.

2016-01-01

The purpose of this chapter is to introduce the concept of Market Based Measures (MBMs) to reduce Green House Gas (GHG) emissions from ships, and review several distinct MBM proposals that have been under consideration by the International Maritime Organization (IMO). The chapter discusses the me...... the mechanisms used by MBMs, and explores how the concept of the Marginal Abatement Cost (MAC) can be linked to MBMs. It also attempts to discuss the pros and cons of the submitted proposals....

Inbound Marketing - the most important digital marketing strategy

Directory of Open Access Journals (Sweden)

PATRUTIU-BALTES Loredana

2017-01-01

Full Text Available Digital marketing has a major importance in the marketing strategy of any company regardless of sector, size or country of origin. Thus, more than ever, in order to remain competitive, companies are forced to exploit this form of marketing, which essentially can bring huge benefits at low costs. The main form of digital marketing is the inbound marketing, which represents an organic marketing form, based on the close relationship between the company and its prospects or customers, who have expressed their interest in the company’s products voluntarily (based on subscription to newsletters, blog, social networks, etc. and who have been attracted and involved by a high quality of the content marketing.

Value Based International Relationship Marketing

NARCIS (Netherlands)

Dr. Ulrich Scholz

2009-01-01

The developement of a "general theory" of relationship marketing must be considered as distant vision rather than as imminent reality.We now use the existing stock of knowledge to identify some largely unexplored,yet relevant, aspects of relationship marketing and call for these issues to be

Android Based Binus Profile Applications as the Marketing Tools of Bina Nusantara University

Directory of Open Access Journals (Sweden)

Iskandar Karto

2014-03-01

Full Text Available Smart phones with apps in it is not a new phenomenon. Both of technologies have been fused with the lifestyle today. The ease and speed of access to information makes a lot of companies use it in the process of marketing a product to the public. Objective of this action is to win the competition that more competitive. The purpose of this research is to create mobile application android based to assist in the marketing and introduction Bina Nusantara University profile to prospective students. This research method using software engineering waterfall model to produce Android-based mobile applications. The results in the form of Android-based mobile application that can be used as a viral marketing tool for Bina Nusantara University. At the end of this study can be generated that mobile technology can be used as a media for effective marketing and branding, especially for Bina Nusantara University. Android technology based for marketing applications suited to the Bina Nusantara University applicant segment which are generally young people. The future along with the improvement of network quality and affordable cost, then the application can be made online, so features such as chat, maps, and other can be used optimally.

Understanding agent-based models of financial markets: A bottom-up approach based on order parameters and phase diagrams

Science.gov (United States)

Lye, Ribin; Tan, James Peng Lung; Cheong, Siew Ann

2012-11-01

We describe a bottom-up framework, based on the identification of appropriate order parameters and determination of phase diagrams, for understanding progressively refined agent-based models and simulations of financial markets. We illustrate this framework by starting with a deterministic toy model, whereby N independent traders buy and sell M stocks through an order book that acts as a clearing house. The price of a stock increases whenever it is bought and decreases whenever it is sold. Price changes are updated by the order book before the next transaction takes place. In this deterministic model, all traders based their buy decisions on a call utility function, and all their sell decisions on a put utility function. We then make the agent-based model more realistic, by either having a fraction fb of traders buy a random stock on offer, or a fraction fs of traders sell a random stock in their portfolio. Based on our simulations, we find that it is possible to identify useful order parameters from the steady-state price distributions of all three models. Using these order parameters as a guide, we find three phases: (i) the dead market; (ii) the boom market; and (iii) the jammed market in the phase diagram of the deterministic model. Comparing the phase diagrams of the stochastic models against that of the deterministic model, we realize that the primary effect of stochasticity is to eliminate the dead market phase.

78 FR 26258 - Approval and Promulgation of Air Quality Implementation Plans; Illinois; Consumer Products and...

Science.gov (United States)

2013-05-06

... adopt these VOC limits to create more consistency in regional and national markets for consumer products... organic compound (VOC) content limits and associated provisions for additional consumer products categories into the state's SIP. Finally, EPA is approving language to clarify VOC limit applicability for...

77 FR 55451 - Notice of Intent To Request an Extension of a Currently Approved Information Collection

Science.gov (United States)

2012-09-10

..., marketing, technical, and financial resources to carry out the submitted plan. Estimate of Burden: Public... DEPARTMENT OF AGRICULTURE Agricultural Research Service Notice of Intent To Request an Extension of a Currently Approved Information Collection AGENCY: Agricultural Research Service, USDA. [[Page...

75 FR 16224 - Self-Regulatory Organizations; the NASDAQ Stock Market LLC; Notice of Filing and Immediate...

Science.gov (United States)

2010-03-31

... Proposed Rule Change To Delay the Application of NASDAQ Rule 4611(d) March 24, 2010. Pursuant to Section 19... rule change to delay the application of NASDAQ Rule 4611(d) until 180 days following its approval. The... Market Access Rule. Accordingly, NASDAQ is proposing to delay for 180 days from approval the...

Cell-Based Veterinary Pharmaceuticals - Basic Legal Parameters Set by the Veterinary Pharmaceutical Law and the Genetic Engineering Law of the European Union.

Science.gov (United States)

Faltus, Timo; Brehm, Walter

2016-01-01

Cell-based therapies have been in use in veterinary medicine for years. However, the legal requirement of manufacturing, placing on the market and use of cell-based veterinary pharmaceuticals are not as well developed as the respective requirements of chemical pharmaceuticals. Cell-based veterinary pharmaceuticals are medicinal products in the sense of the pharmaceutical law of the European Union (EU). For that reason, such medicinal products principally require official approval for their manufacture and an official marketing authorization for their placement on the market before being used by the veterinarian. The manufacture, placing on the market, and use of cell-based veterinary pharmaceuticals without manufacturing approval and marketing authorization is permitted only in certain exceptional cases determined by EU and individual Member State law. Violations of this requirement may have consequences for the respective veterinarian under criminal law and under the code of professional conduct in the respective Member State. The regular use of cell-based veterinary pharmaceuticals within the scope of a therapeutic emergency as well as the import of such veterinary pharmaceuticals from non-European countries for use in the EU are currently out of the question in the EU because of a lack of legal bases. Here, we review the general legal requirement of manufacturing, placing on the market, and use of cell-based veterinary pharmaceuticals within the EU and point out different implementations of EU law within the different Member States.

Contract-based electricity markets in developing countries: Overcoming inefficiency constraints

Science.gov (United States)

Perera, M. N. Susantha

The electric utility sector throughout the world has been undergoing significant changes. It is changing from its traditional, central-station generation model managed under a vertically integrated monopoly to a more market-dependent business. In the rich industrialized countries, this change has progressed rapidly with the emergence of competitive markets---not only in the area of electricity generation, but also in the extension of such markets down to the level of retail domestic consumer. Developing countries, on the other hand, are trying to attract much-needed investment capital for their power sector expansion activities, particularly for the expansion of generating capacity, through the involvement of the private sector. Unlike their industrialized counterparts, they are facing many limitations in transforming the mostly government-owned monopolies into market-driven businesses, thereby creating an environment that is conducive to private sector participation. Amongst these limitations are the lack of a well-developed, local private sector or domestic financial market that can handle the sophisticated power sector financing; inadequate legal and regulatory frameworks that can address the many complexities of private power development; and numerous risk factors including political risks. This dissertation research addresses an important inefficiency faced by developing countries in the new contract-based market structure that has emerged within these countries. It examines the inefficiencies brought on by restrictions in the contracts, specifically those arising from the guaranteed purchase conditions that are typically included in contracts between the purchasing utility and independent power producers in this new market. The research attempts to provide a solution for this problem and proposes a methodology that enables the parties to conduct their businesses in a cost-efficient manner within a cooperative environment. The situation described above is

77 FR 75933 - Approval and Promulgation of Air Quality Implementation Plans; West Virginia; The 2002 Base Year...

Science.gov (United States)

2012-12-26

... email. The www.regulations.gov Web site is an ``anonymous access'' system, which means EPA will not know... Promulgation of Air Quality Implementation Plans; West Virginia; The 2002 Base Year Emissions Inventory for the...: Proposed rule. SUMMARY: EPA is proposing to approve the 2002 base year emissions inventory portion of the...

How much market do market-based instruments create? An analysis for the case of 'white' certificates

International Nuclear Information System (INIS)

Langniss, Ole

2003-01-01

Discussions about 'green' certificates for renewable energy forms are under way for some time now. In contrast, tradable 'white' certificates have only lately been celebrated as a market-based tool to foster energy efficiency. Theoretically, there is little doubt about this. In practice, however, some fundamental problems and doubts about the usefulness of certificates arise: How 'competitive' are markets for certificates in reality? Is a 'white' certificate scheme only a new name for an old hat rooted in control and command regulation? With this suspicion, a number of questions and aspects arise: - Market mechanism: Which criteria guarantee that an - artificial - market for certificates really becomes competitive? Will trading be characterized by spot markets or by rather anti-competitive long-term over-the-counter contracts? Which minimum market size is needed, and which are the conditions regarding the tradability of the certificate that have to be met? - Target group: Who should be obliged to purchase certificates? Are electricity suppliers the right target group, or should fuel and heat suppliers be addressed, or the consumer himself? - Additionality and measurability: Which efficiency technologies should be eligible for certificates? What exactly is an efficient technology? A narrow definition might ease measuring problems but at the same time reduce innovation incentives. We use the theoretical framework of Transaction Cost Economics to discuss these issues. A brief review of the design of tradable certificate schemes in Italy and the UK is given. Lessons can also be learned from renewable portfolio standards recently implemented in a number of countries

A History of the Sonocare CST-100: The First FDA-approved HIFU Device

Science.gov (United States)

Muratore, Robert

2006-05-01

The Sonocare CST-100 Therapeutic Ultrasound System, designed for the treatment of glaucoma, was developed in the 1980s and became the first high intensity focused ultrasound (HIFU) device to receive Food and Drug Administration approval. The system arose from studies done by F.L. Lizzi, Eng.Sc.D., of Riverside Research Institute and D.J. Coleman, M.D., of Cornell Medical Center/New York Hospital on the safety of ultrasound diagnosis of the eye. As safety limits were probed, therapeutic regimes were discovered. Optimization of operational parameters, clinical experience, and engineering design came together through a spin-off company, Sonocare, Inc., formed to produce and market the ophthalmic device. Various precedents were set during the approval process, including the acceptance by the FDA of radiation momentum imparted to an absorber as a measure of acoustic power. Many devices were sold, but the laser industry, grandfathered into the therapeutic field, eventually out-marketed Sonocare. The CST-100 remains as a model of elegant industrial design, and existing units are used daily in HIFU laboratory experiments.

48 CFR 52.222-16 - Approval of Wage Rates.

Science.gov (United States)

2010-10-01

... 48 Federal Acquisition Regulations System 2 2010-10-01 2010-10-01 false Approval of Wage Rates. 52....222-16 Approval of Wage Rates. As prescribed in 22.407(b), insert the following clause: Approval of Wage Rates (FEB 1988) All straight time wage rates, and overtime rates based thereon, for laborers and...

British Columbia natural gas: Core market policy

International Nuclear Information System (INIS)

1988-06-01

The core market for natural gas in British Columbia is defined as all natural gas consumers in the residential, institutional, commercial, and industrial sectors not currently purchasing natural gas directly and not exempted from the core market by the British Columbia Utilities Commission (BCUC). The intent of the definition is to include all customers who must be protected by contracts which ensure long-term security of supply and stable prices. Core market customers are excluded from direct natural gas purchase and will be served by distribution utilities. A customer may apply to BCUC to leave the core market; such an application may be approved if it is demonstrated that the customer has adequate long-term natural gas supplies or alternative fuel supplies to protect him from supply interruptions. The non-core market is defined as all large industrial customers who elect to make their own natural gas supply arrangements and who can demonstrate to the BCUC sufficient long-term natural gas supply protection or alternative fuel capability to ensure security of the industry. Non-core market customers have full and open access to the competitive natural gas market. The British Columbia government will not apply its core market policy to other jurisdictions through Energy Removal Certificates

Use of Fixed Dose Combination (FDC) Drugs in India: Central Regulatory Approval and Sales of FDCs Containing Non-Steroidal Anti-Inflammatory Drugs (NSAIDs), Metformin, or Psychotropic Drugs

Science.gov (United States)

McGettigan, Patricia; Roderick, Peter; Mahajan, Rushikesh; Kadam, Abhay; Pollock, Allyson M.

2015-01-01

Background In 2012, an Indian parliamentary committee reported that manufacturing licenses for large numbers of fixed dose combination (FDC) drugs had been issued by state authorities without prior approval of the Central Drugs Standard Control Organization (CDSCO) in violation of rules, and considered that some ambiguity until 1 May 2002 about states’ powers might have contributed. To our knowledge, no systematic enquiry has been undertaken to determine if evidence existed to support these findings. We investigated CDSCO approvals for and availability of oral FDC drugs in four therapeutic areas: analgesia (non-steroidal anti-inflammatory drugs [NSAIDs]), diabetes (metformin), depression/anxiety (anti-depressants/benzodiazepines), and psychosis (anti-psychotics). Methods and Findings This was an ecologic study with a time-trend analysis of FDC sales volumes (2007–2012) and a cross-sectional examination of 2011–2012 data to establish the numbers of formulations on the market with and without a record of CDSCO approval (“approved” and “unapproved”), their branded products, and sales volumes. Data from the CDSCO on approved FDC formulations were compared with sales data from PharmaTrac, a database of national drug sales. We determined the proportions of FDC sales volumes (2011–2012) arising from centrally approved and unapproved formulations and from formulations including drugs banned/restricted internationally. We also determined the proportions of centrally approved and unapproved formulations marketed before and after 1 May 2002, when amendments were made to the drug rules. FDC approvals in India, the United Kingdom (UK), and United States of America (US) were compared. For NSAID FDCs, 124 formulations were marketed, of which 34 (27%) were centrally approved and 90 (73%) were unapproved; metformin: 25 formulations, 20 (80%) approved, five (20%) unapproved; anti-depressants/benzodiazepines: 16 formulations, three (19%) approved, 13 (81%) unapproved

Value at risk estimation with entropy-based wavelet analysis in exchange markets

Science.gov (United States)

He, Kaijian; Wang, Lijun; Zou, Yingchao; Lai, Kin Keung

2014-08-01

In recent years, exchange markets are increasingly integrated together. Fluctuations and risks across different exchange markets exhibit co-moving and complex dynamics. In this paper we propose the entropy-based multivariate wavelet based approaches to analyze the multiscale characteristic in the multidimensional domain and improve further the Value at Risk estimation reliability. Wavelet analysis has been introduced to construct the entropy-based Multiscale Portfolio Value at Risk estimation algorithm to account for the multiscale dynamic correlation. The entropy measure has been proposed as the more effective measure with the error minimization principle to select the best basis when determining the wavelet families and the decomposition level to use. The empirical studies conducted in this paper have provided positive evidence as to the superior performance of the proposed approach, using the closely related Chinese Renminbi and European Euro exchange market.

Profitability and Market Value of Orphan Drug Companies: A Retrospective, Propensity-Matched Case-Control Study.

Science.gov (United States)

Hughes, Dyfrig A; Poletti-Hughes, Jannine

2016-01-01

Concerns about the high cost of orphan drugs has led to questions being asked about the generosity of the incentives for development, and associated company profits. We conducted a retrospective, propensity score matched study of publicly-listed orphan companies. Cases were defined as holders of orphan drug market authorisation in Europe or the USA between 2000-12. Control companies were selected based on their propensity for being orphan drug market authorisation holders. We applied system General Method of Moments to test whether companies with orphan drug market authorization are valued higher, as measured by the Tobin's Q and market to book value ratios, and are more profitable based on return on assets, than non-orphan drug companies. 86 companies with orphan drug approvals in European (4), USA (61) or both (21) markets were matched with 258 controls. Following adjustment, orphan drug market authorization holders have a 9.6% (95% confidence interval, 0.6% to 18.7%) higher return on assets than non-orphan drug companies; Tobin's Q was higher by 9.9% (1.0% to 19.7%); market to book value by 15.7% (3.1% to 30.0%) and operating profit by 516% (CI 19.8% to 1011%). For each additional orphan drug sold, return on assets increased by 11.1% (0.6% to 21.3%), Tobin's Q by 2.7% (0.2% to 5.2%), and market to book value ratio by 5.8% (0.7% to 10.9%). Publicly listed pharmaceutical companies that are orphan drug market authorization holders are associated with higher market value and greater profits than companies not producing treatments for rare diseases.

Bidding strategy for pumped-storage plant in pool-based electricity market

International Nuclear Information System (INIS)

Kanakasabapathy, P.; Shanti Swarup, K.

2010-01-01

This paper develops optimal bidding strategies for a pumped-storage plant in a pool-based electricity market. In the competitive regime, when compared to simple hydroelectric generator, profit of the pumped-storage plant is maximized by operating it as a generator when market clearing price is high and as a pump when the price is low. Based on forecasted hourly market clearing price, a multistage looping algorithm to maximize the profit of a pumped-storage plant is developed, considering both the spinning and non-spinning reserve bids and meeting the technical operating constraints of the plant. The proposed model is adaptive for the nonlinear three-dimensional relationship between the power produced, the energy stored, and the head of the associated reservoir. Different operating cycles for a realistic pumped-storage plant are considered and simulation results are reported and compared. (author)

Cell-Based Veterinary Pharmaceuticals – Basic Legal Parameters Set by the Veterinary Pharmaceutical Law and the Genetic Engineering Law of the European Union

Science.gov (United States)

Faltus, Timo; Brehm, Walter

2016-01-01

Cell-based therapies have been in use in veterinary medicine for years. However, the legal requirement of manufacturing, placing on the market and use of cell-based veterinary pharmaceuticals are not as well developed as the respective requirements of chemical pharmaceuticals. Cell-based veterinary pharmaceuticals are medicinal products in the sense of the pharmaceutical law of the European Union (EU). For that reason, such medicinal products principally require official approval for their manufacture and an official marketing authorization for their placement on the market before being used by the veterinarian. The manufacture, placing on the market, and use of cell-based veterinary pharmaceuticals without manufacturing approval and marketing authorization is permitted only in certain exceptional cases determined by EU and individual Member State law. Violations of this requirement may have consequences for the respective veterinarian under criminal law and under the code of professional conduct in the respective Member State. The regular use of cell-based veterinary pharmaceuticals within the scope of a therapeutic emergency as well as the import of such veterinary pharmaceuticals from non-European countries for use in the EU are currently out of the question in the EU because of a lack of legal bases. Here, we review the general legal requirement of manufacturing, placing on the market, and use of cell-based veterinary pharmaceuticals within the EU and point out different implementations of EU law within the different Member States. PMID:27965965

The European Medicines Agency's approval of new medicines for type 2 diabetes.

Science.gov (United States)

Blind, Eberhard; Janssen, Heidi; Dunder, Kristina; de Graeff, Pieter A

2018-05-08

Since 2005, more than 40 new medicines for the treatment of type 2 diabetes have been introduced on the market. These consist of 15 new active substances establishing three new classes of non-insulin products, and several new or modified insulin products and combinations. The approval of these products in Europe is regulated via the centralized procedure at the European Medicines Agency. Demonstration of benefit with regard to improved glucose control remains the principal outcome required from confirmatory studies to demonstrate efficacy. For the majority of these new medicines approved since 2005, cardiovascular outcome trials have now been completed, and have invariably supported the cardiovascular safety of these products. In some of these trials additional important benefits have been observed, for instance, a reduction in major adverse cardiovascular events and improvement of renal outcome. The existing regulatory framework and the continuous adaption of regulatory requirements to emerging developments will continue to guide the approval of new products in the future. © 2018 John Wiley & Sons Ltd.

77 FR 52096 - Self-Regulatory Organizations; EDGX Exchange, Inc.; Order Approving a Proposed Rule Change, as...

Science.gov (United States)

2012-08-28

...'s rules, the financial and regulatory risk management controls and supervisory procedures required...-Regulatory Organizations; EDGX Exchange, Inc.; Order Approving a Proposed Rule Change, as Modified by... that broker-dealers appropriately control the risks associated with market access, so as not to...

Market interdependence among commodity prices based on information transmission on the Internet

Science.gov (United States)

Ji, Qiang; Guo, Jian-Feng

2015-05-01

Human behaviour on the Internet has become a synchro-projection of real society. In this paper, we introduce the public concern derived from query volumes on the Web to empirically analyse the influence of information on commodity markets (e.g., crude oil, heating oil, corn and gold) using multivariate GARCH models based on dynamic conditional correlations. The analysis found that the changes of public concern on the Internet can well depict the changes of market prices, as the former has significant Granger causality effects on market prices. The findings indicate that the information of external shocks to commodity markets could be transmitted quickly, and commodity markets easily absorb the public concern of the information-sensitive traders. Finally, the conditional correlation among commodity prices varies dramatically over time.

40 CFR 52.2479 - Contents of the federally approved, State submitted implementation plan.

Science.gov (United States)

2010-07-01

... [09/17/90] 173-430-040 Mobile field burners [09/17/90] 173-430-050 Other approvals [09/17/90] 173-430... General Definitions [12/11/80] Section 1.05 Special Definitions [9/9/99] Article 2—Gasoline Marketing...] Section 3.03 Can and Paper Coating Operations [2/10/94] Section 3.04 Motor Vehicle and Mobile Equipment...

75 FR 14342 - Market-Based Rates for Wholesale Sales of Electric Energy, Capacity and Ancillary Services by...

Science.gov (United States)

2010-03-25

...; Order No. 697-D] Market-Based Rates for Wholesale Sales of Electric Energy, Capacity and Ancillary... affiliates.\\3\\ \\1\\ Market-Based Rates for Wholesale Sales of Electric Energy, Capacity and Ancillary Services...\\ Market-Based Rates for Wholesale Sales of Electric Energy, Capacity and Ancillary Services by Public...

Competition and equilibria in electricity markets based on two-settlement system: A conjectural variation approach

Science.gov (United States)

Watts, David

This dissertation studies electricity markets based on two-settlement systems and applies the concept of conjectural variation (CV) as a tool for representing different levels of competitiveness in the market. Some recent theoretical works are addressed to support the use of CV as a solution concept. A notion of consistency is introduced to make the level of competitiveness of the market endogenous, and allows finding consistent CV equilibria and the corresponding conditions for existence of equilibria. First, a case is studied in which firms hold exogenous levels of forward commitments. Then, backward induction and sub-game perfection are used to solve sequentially for the spot and forward market equilibrium. This allows analyzing how firms take positions in the forward market, based on considering their later impact on the spot market. It is concluded that positions taken in the forward market depend largely on firms expectations about the competitiveness of both the spot and the forward market. Forward markets are welfare enhancing even if they are not as competitive as the associated spot market as long as they are not too oligopolistie. The above formulation is used to model a dynamic scenario to analyze market stability, linking this research to Dr. Alvarado's earlier research on market stability. This brings about interesting trade offs between market power and market stability.

Evolution and perspectives of gas market

International Nuclear Information System (INIS)

Russo, S.

1998-01-01

The gas market in Europe, and thus in Italy, will see great changes as regards the market, the deployment of forces on the ground, the structure of the demand and, in the longer term, that of the offer. It is important to look at the future after having gone through, although in brief, the stages of the development of the gas market in Europe and in Italy, from the origins, in the years 1950-60, up today. It is not difficult to see how the organization of the market, up to now, has been oriented prevailingly at the development and at the security of supplies to the consumer. The future will focus on the improvement of the global efficiency of the gas system with the aim of reducing costs, yet for the final users. The realization of this transition has already begun and it is demonstrated by the evolution of both the institutional and regulatory framework already under way, in Europe with the just approved gas directive, and in Italy with the appointment of the market regulation Authority. It is difficult challenge to which the gas industry will answer adequately [it

75 FR 63229 - Self-Regulatory Organizations; The NASDAQ Stock Market LLC; Notice of Filing and Immediate...

Science.gov (United States)

2010-10-14

...-Regulatory Organizations; The NASDAQ Stock Market LLC; Notice of Filing and Immediate Effectiveness of... hereby given that on October 1, 2010, The NASDAQ Stock Market LLC (``NASDAQ'' or the ``Exchange'') filed... has received approval to launch NASDAQ OMX PSX (``PSX'') \\3\\ as a new platform for trading NMS stocks...

76 FR 2732 - Self-Regulatory Organizations; The NASDAQ Stock Market LLC; Notice of Designation of Longer...

Science.gov (United States)

2011-01-14

...-Regulatory Organizations; The NASDAQ Stock Market LLC; Notice of Designation of Longer Period for Commission.... Introduction On June 18, 2010, The NASDAQ Stock Market LLC (``Nasdaq'' or the ``Exchange'') filed with the... change. The Commission may extend the period for issuing an order approving or disapproving the proposed...

Security cost analysis in electricity markets based on voltage security criteria and Web-based implementation

International Nuclear Information System (INIS)

Chen, H.

2003-01-01

This paper presents an efficient and transparent method for electricity market operators to analyze transaction security costs and to quantify the correlation between market operation and power system operation. Rescheduling and take-risk strategies were proposed and discussed with reference to transaction impact computations, thermal and voltage limits and voltage stability criteria. The rescheduling method is associated with an iterative generation dispatch or load curtailment approach to minimize the amount of rescheduling. The take-risk method considered operating risks to facilitate transactions. The SATC concept was also proposed to accurately evaluate transmission congestion. The impact of transaction was calculated using a new sensitivity formula to find the most effective rescheduling direction and the most effective cost distribution. A new pricing method called Nodal Congestion Price was also proposed to determine proper price signals. The paper also presents an Artificial Neural Network (ANN) based short term load forecasting method that considers the effect of price on the load. A web-based prototype was implemented to allow all market participants access to the proposed analysis and pricing techniques. Several case studies have validated the effectiveness of the proposed method which would help independent system operators in determining congestion prices, coordinate transactions and make profitable market decisions

Constructing and Contesting Markets through the Market Object

OpenAIRE

Finch, John; Geiger, Susi

2011-01-01

This paper focuses on the work that market actors undertake in order to stabilize and de-stabilize market objects. We briefly revisit Igor Ansoff's classic product–market strategy matrix to show how marketing management literature typically equates stability in markets with commodification and inertia. To escape this inertia, marketers often ‘warm up’ or destabilize existing market objects by changing the material bases of the object, for instance in incremental product development. But this ...

The Evolution of ICT Markets: An Agent-Based Model on Complex Networks

Science.gov (United States)

Zhao, Liangjie; Wu, Bangtao; Chen, Zhong; Li, Li

Information and communication technology (ICT) products exhibit positive network effects.The dynamic process of ICT markets evolution has two intrinsic characteristics: (1) customers are influenced by each others’ purchasing decision; (2) customers are intelligent agents with bounded rationality.Guided by complex systems theory, we construct an agent-based model and simulate on complex networks to examine how the evolution can arise from the interaction of customers, which occur when they make expectations about the future installed base of a product by the fraction of neighbors who are using the same product in his personal network.We demonstrate that network effects play an important role in the evolution of markets share, which make even an inferior product can dominate the whole market.We also find that the intensity of customers’ communication can influence whether the best initial strategy for firms is to improve product quality or expand their installed base.

Evidence-Based Marketing for Academic Librarians

OpenAIRE

Yoo-Seong Song

2006-01-01

Objective - In developing marketing strategies for the Business & Economics Library (BEL) at the University of Illinois at Urbana-Champaign (UIUC), a survey was designed to answer the following questions: - Should BEL develop marketing strategies differently for East Asian business students? - What services do graduate business students want to receive from BEL? - With whom should BEL partner to increase visibility at the College of Business? Marketing research techniques were used to g...

Impact of Germany's energy transition on the Nordic power market – A market-based multi-region energy system model

International Nuclear Information System (INIS)

Zakeri, Behnam; Virasjoki, Vilma; Syri, Sanna; Connolly, David; Mathiesen, Brian V.; Welsch, Manuel

2016-01-01

The EU energy policy aims at creating a single European electricity market through market couplings and grid expansions. To analyse the implications of such power market couplings, we propose a market-based multi-region energy system model. The model simulates a multi-region power market (by applying market optimization and network theory), with detailed representation of each region as an energy system (by simulation of both heat and power sectors). We examine the impact of further integration of variable renewable energy (VRE) in Germany on the Nordic power market. The results indicate that the average electricity price slightly grows in the Nordic power market after Germany's Energy Transition (Energiewende). Hence, the economic surplus of Nordic consumers diminishes while Nordic producers improve their gain under new market conditions. Considering the gird congestion income, the overall system-level benefits (social welfare) will improve in the Nordic region after Germany's Energiewende. However, this gain is not equally distributed among different Nordic countries and across different stakeholders. Furthermore, the Energiewende slightly increases carbon emissions from power and district heating (DH) sectors, and reduces the flexibility in integration of VRE in some Nordic countries like Denmark. The direct interconnection of Norway and Germany through NordLink will contribute to the flexibility in wind integration in other Nordic countries, such as Denmark and Finland. - Highlights: • By an integrated hourly analysis, we model the energy systems of several networked countries and their common electricity market. • The proposed model can inform energy policy on implications of renewable energy integration in an international power market. • Among Nordic countries, Norway gains the highest economic benefits from Germany's energy transition. • Germany's energy transition constrains the flexibility of the Nordic countries in wind integration. • Nord

Analysis of Marketing and Customer Satisfaction in Base Housing Communities of the Monterey Bay Area

Science.gov (United States)

2011-06-01

in Seattle, Washington. The company claims to be based on four basic principles : “exceptional people, strong customer service, market knowledge, and...FtOrd.html Keller, K., & Kotler , P. (2009). A framework for marketing management. Upper Saddle River, NJ: Pearson Education, Inc. Office of...SUBTITLE Analysis of Marketing and Customer Satisfaction in Base Housing Communities of the Monterey Bay Area 5. FUNDING NUMBERS 6. AUTHOR(S

Establishment approval in international trade of animal products

NARCIS (Netherlands)

Rau, M.L.; Ge, L.; Valeeva, N.I.; Wagenberg, van C.P.A.

2012-01-01

This report provides an overview of different approaches of establishment approval as well as its implementation and organisation in international agrifood trade. The focus is on animal products as establishment approval is particularly used for exporting these products. Based on trade data, 8

Web-Based Implementation of E-Marketing to Support Product Marketing of Chemical Manufacturing Company

Directory of Open Access Journals (Sweden)

Riswan Efendi Tarigan

2015-10-01

Full Text Available Currently, many company’s marketing strategies are limited only to face-to-face communication, telephone, facsimile, company portfolio, and product brochures. However, those marketing strategies are well- known to have limited impacts. Therefore, the presence of e-marketing as one of the marketing strategies would be appropriate to cover the weaknesses and to solve a number of the marketing problems. The purpose of this study is to discuss matters related to marketing, such    as, proposing a marketing plan using website, expanding marketing segment, and introducing existing  products for a chemical manufacturing company. The adopted research method is a descriptive method where the study is directly performed on the research object to acquire necessary data. The collected data are further analyzed using the Porter’s Five Force and SWOT analysis. Fi- nally, the work provides a number of recommendations for implementing e-marketing strategies to support the company business.

The Simulation of Financial Markets by an Agent-Based Mix-Game Model

OpenAIRE

Chengling Gou

2006-01-01

This paper studies the simulation of financial markets using an agent-based mix-game model which is a variant of the minority game (MG). It specifies the spectra of parameters of mix-game models that fit financial markets by investigating the dynamic behaviors of mix-game models under a wide range of parameters. The main findings are (a) in order to approach efficiency, agents in a real financial market must be heterogeneous, boundedly rational and subject to asymmetric information; (b) an ac...

Market drivers and challenges for gasification-based power plants in Europe

Energy Technology Data Exchange (ETDEWEB)

Juergen Karg; Frank Hannemann [Siemens Power Generation (PG) (Germany)

2006-07-01

The paper begins by examining the present situation and future trends in the power generation market, before discussing existing IGCC plants and present market activities. IGCC plants in which Siemens are involved are given and coal-based IGCC applications are described. Finally improvement potential of IGCC, and technologies towards zero emission plants (including CO{sub 2} capture and sequestration) are discussed. 19 refs., 7 figs., 3 tabs.

77 FR 11531 - Electric Quarterly Reports, Acacia Energy, Inc., et al.; Notice of Revocation of Market-Based...

Science.gov (United States)

2012-02-27

...-000 Nordic Marketing of Illinois, Docket No. ER03-888-000 L.L.C. Nordic Marketing of Michigan, Docket No. ER04-264-000 L.L.C. Nordic Marketing, L.L.C Docket No. ER00-774-000 Pirin Solutions, Inc Docket... (including market-based power sales, cost-based power sales, and transmission service) and providing...

Marketing Sustainable Retail Development

Directory of Open Access Journals (Sweden)

Dragan Ilić

2013-06-01

Full Text Available One of the primary benefits of sustainable retail over the long run has to be the marketing gain from having something other competitors do not: lower operating costs, a more socially responsible public profile, ease of gaining planning approval for new projects, better access to certain investment pools, higher rents (in the case of developers, ease of recruiting and retaining key people. Each of these benefits needs marketing and public relations support; each benefits from a clear and consistent corporate message that promotes sustainable retail. To date, there are very few retailers or developers who have championed sustainability long enough, consistently enough and with enough actual demonstration of changes in standard operations to gain the benefits of green marketing, but the very paucity of examples serves to underscore the point: the green marketing space is wide open for large retailers and developers. What would be the marketing steps that a company could take to benefit from its “sustainability focus?” The key to any marketing program is to differentiate a company’s actions from those of competitors and to do it along lines that its various stakeholders care about. This practice of differentiation is often expressed as “finding a difference that makes a difference, to someone who makes difference to you.” For retail developers, the first differentiator should be to attract more and better tenants to all of their centers, tenants who value lower operating costs and the developer’s program of sustainable development and corporate social responsibility.

The NOx Budget. Market-based control of tropospheric ozone in the northeastern United States

International Nuclear Information System (INIS)

Farrell, Alex; Carter, Robert; Raufer, Roger

1999-01-01

The NOx Budget is a marketable emissions allowance system currently being adopted by states in the Northeastern US to reduce tropospheric ozone concentrations to healthful levels in a cost-effective manner. Oxides of nitrogen (NOx) are currently regulated within the existing Command and Control (CAC) framework. The introduction of a market-based approach will further reduce emissions, but will not resolve all regulatory uncertainties. These implementation concerns are identified and discussed. Cost savings and emissions reductions patterns which will arise under several different scenarios are determined through the use of a dynamic, relaxed mixed-integer linear programming model of the NOx allowance market. Like other market-based pollution control programs, the NOx Budget is found to be more efficient than CAC options. Restrictions on the market designed to address perceived flaws are found to be expensive but ineffectual

Excipients and their role in approved injectable products: current usage and future directions.

Science.gov (United States)

Nema, Sandeep; Brendel, Ronald J

2011-01-01

This review article is a current survey of excipients used in approved injectable products. Information provided includes concentration ranges, function, frequency of use, and role in dosage form. This article is an update of a paper published more than a decade ago (reference 11). Since then many new products have been approved. Safety concerning excipients has evolved as the scientific community continues to learn about their usage. New excipients are being used in early phases of clinical trials to support novel therapeutic entities like RNAi, aptamers, anti-sense, fusion proteins, monoclonal antibodies, and variant scaffolds. Because these excipients are not inert, various pharmacopoeias are responding with monographs or informational chapters addressing excipient functionality. The final sections of this article discuss new excipients, serving specific needs that traditional excipients are unable to provide and for which safety studies are necessary to support a novel excipient for marketing applications. Excipients are added to parenteral dosage forms to serve a variety of functions including stabilization and as vehicles. This review article is a survey of excipients used in approved injectable products. Information provided includes excipient concentrations, functional roles, and frequency of use. This article is an update of an article originally published over a decade ago. Since then new products have been approved and safety concerns have evolved as the scientific community has learned about the usage of excipients. In addition, new excipients are being used in early phases of clinical trials to support novel therapeutic entities such as RNAi, aptamers, anti-sense, fusion proteins, monoclonal antibodies, and variant scaffolds. Because these excipients are not inert, various pharmacopoeias are responding with monographs or informational chapters addressing excipient functionality. The final sections of this article discuss new excipients, serving

Inbound Marketing - the most important digital marketing strategy

OpenAIRE

PATRUTIU-BALTES Loredana

2017-01-01

Digital marketing has a major importance in the marketing strategy of any company regardless of sector, size or country of origin. Thus, more than ever, in order to remain competitive, companies are forced to exploit this form of marketing, which essentially can bring huge benefits at low costs. The main form of digital marketing is the inbound marketing, which represents an organic marketing form, based on the close relationship ...

Biometrics-based service marketing issues: exploring acceptability and risk factors of iris scans associated with registered travel programmes.

Science.gov (United States)

Smith, Alan D

2008-01-01

The marketability and viability of biometric technologies by companies marketing their own versions of pre-approved registered travel programmes have generated a number of controversies. Data were collected and analysed to formulate graphs, run regression and correlation analyses, and use Chi-square to formally test basic research propositions on a sample of 241 professionals in the Pittsburgh area. It was found that there was a significant relationship between the respondents' familiarity with new technology (namely web-enabled and internet sophistication) and knowledge of biometrics, in particular iris scans. Participants who frequently use the internet are more comfortable with innovative technology; although individuals with higher income levels have less trust in the government, it appeared that virtually everyone is concerned about trusting the government with their personal information. Healthcare professionals need to document the safety, CRM-related factors, and provide leadership in the international collaboration of biometric-related personal identification technologies, since they will be one of the main beneficiaries of the implementation of such technologies.

Analýza učebnice pro odborný předmět Marketing SOŠ

OpenAIRE

Dufek, Ondřej

2015-01-01

This bachelor thesis is focused on evaluation of complexity of a marketing textbook for high school with business focus as a didactic text. In the part Present state of knowledge, the work deals with the importance of performance rating of textbooks and different methodological approaches. In the practical part the market with marketing textbooks for secondary schools with business focus is analysed and an analysis of textbook Marketing by Moudrý, M., which hasn't an approval clause from the ...

Test marketing for value-added root and tuber based products in ...

African Journals Online (AJOL)

Test marketing for value-added root and tuber based products in Ikwuano local government area ... JE Ewuziem, C Aniedu, E Oti, VO Onyenobi ... root and tuber based products, developed at National Root Crops Research Institute, Umudike.

What to Know About Medicines With New Active Ingredients Approved in FY 2016 / 2016 in Japan and EU: A Brief Comparison of New Medicines Approved in Japan and the EU in 2016.

Science.gov (United States)

Kondo, Hideyuki; Saint-Raymond, Agnès; Yasuda, Naoyuki

2018-03-01

The Pharmaceuticals and Medical Devices Agency (PMDA) in Japan and the European Medicines Agency (EMA) have a long-standing experience of reviews of new medicines, and they meet their target pre-market review periods. In FY 2016 / 2016, 112 and 83 new medicines were approved in Japan and EU, respectively. Out of these medicines, 41 and 27 medicines containing new active ingredients were approved with total pre-market review periods of 209 days and 428 days in Japan and EU, respectively. Approximately one-third of these medicines were reviewed by the Agencies in close timing, within 1 year between pre-market review applications in Japan and in EU. Taking into account the increasing number of global clinical trials and constant number of consultations or scientific advice related to global clinical trials in Japan, it is clear that the importance of the continuous, collaborative relationship between EMA and PMDA is more and more crucial, as it does facilitate close and timely exchange of information and opinions on products and technologies under development. There already are effective collaborative frameworks between PMDA and EMA in addition to daily communication, and our findings support the development and best use of regulatory tools such as consultation services and scientific advice/protocol assistance for the benefit of the pharmaceutical industry but mostly of patients.

Mobil/Badger to market zeolite-based cumene technology

International Nuclear Information System (INIS)

Rotman, D.

1993-01-01

Badger (Cambridge, MA) and Mobil (Fairfax, VA) are ready to jointly license a new cumene technology that they say achieves higher yields and product purity than existing processes. The zeolite-based technology is scheduled to be introduced at next month's DeWitt Petrochemical Review in Houston. The Mobil/Badger technology aims to challenge the dominant position of UOP's (Des Plaines, IL) solid phosphoric acid (SPA) catalyst process - which accounts for 80%-90% of the world's cumene production. In addition, Monsanto/Kellogg's aluminum chloride-based technology has gained significant momentum since its introduction in the 1980s. And late last year, ABB Lummus Crest (Bloomfield, NJ) also began marketing a zeolite-based cumene technology. While all the technologies make cumene via the alkylation of benzene with propylene, the Mobil/Badger process uses a zeolite-containing catalyst designed by Mobil to selectively catalyze the benzene/propylene reaction, avoiding unwanted propylene oligomerization. Because the olefin reactions are so fast, says Frank A. Demers, Badger's v.p./technology development and marketing, other zeolite technologies are forced to use complex reactor arrangements to stop the propylene-propylene reactions. However, he says, 'Mobil has designed a catalyst that wants to react benzene with propylene to make cumene.'

Marketing Strategy of Rural Supermarket Chain in Ningxia Based on the Long Tail

Institute of Scientific and Technical Information of China (English)

2011-01-01

Based on the introduction of the Long Tail,the political,economical,social and technological environment for the development of rural supermarket chain in Ningxia is analyzed.The problems in the marketing strategy of Ningxia rural supermarket chain are pointed out,including single products and uneven level of quality,the products,which can not satisfy farmers’ needs;low quality of the personnel and imperfect information system,thus the traditional way of marketing is challenged.In the end,from the perspective of products,position,price,and personnel,the marketing strategies for the development of Ningxia rural supermarket chain based on the Long Tail Theory are put forward.

Analyzing power pools and understanding the spot market based approach to electricity trading

Energy Technology Data Exchange (ETDEWEB)

Goulding, D. [Ontario Hydro, Toronto, ON (Canada)

1997-12-31

Highlights of the evolution of the electricity industry from franchised monopoly to commoditized markets were presented. Trends in commoditized markets include increased competition, a decline in profit margins and increases in price volatility. Examples of highly regulated industries that have commoditized include long distance telephone, airline and the trucking industries. Models of possible market structures for electricity were reviewed, among them: (1) mandatory one-sided spot market, (2) mandatory spot market, less central control, (3) optional two-sided spot market, and (4) physical bilateral based market. Management of the marketplace regardless of the model used, must assure system security and system reliability and meet real-time demand on the system. Possible roles for the Independent System Operator were discussed. The principal role was predicted to be the operation of an electronic exchange for forward contracts, operation of the spot market, and acting as a clearinghouse for buyers and sellers of forward contracts. 1 tab., 4 figs.

First emergency contraceptive product hits U.S. market shelves.

Science.gov (United States)

1998-11-01

The Preven Emergency Contraceptive Kit, a product approved by the US Food and Drug Administration (USFDA) for emergency contraception, is now on the market for sale. Produced by Gynetics of Somerville, NJ, the kit consists of an easy-to-use pregnancy test, patient information guide, and 4 blue pills, each containing 0.05 mg ethinyl estradiol and 0.25 mg levonorgestrel. After a woman determines that she is not pregnant by using the kit's test, she takes 2 pills as soon as possible within 72 hours after having unprotected sexual intercourse. The remaining 2 pills are taken 12 hours later. Although Preven is available now only by prescription, Gynetics will cooperate with the USFDA in assessing whether it should be sold over the counter. One course of Preven costs about $20 at a pharmacy, less than any oral contraceptive pills currently used as emergency contraceptives. The Preven Kit carries Health Care Financing Administration approval for Medicaid reimbursement, and most health maintenance organizations have agreed to cover its costs. Two more progestin-only emergency contraceptive products may enter the US market in 1999. Gynetics is in the advanced stages of developing a levonorgestrel-only emergency contraceptive, while Women's Capital Corp. of Seattle, WA, and Washington, DC, plans to submit its application for product approval to the USFDA for a similar progestin-only product by the end of October.

Competition effects of mergers: An event study of the German electricity market

International Nuclear Information System (INIS)

Keller, Andreas

2010-01-01

This paper investigates the competition effects of the entry of Vattenfall into the German electricity market. While the competition authorities supported the entry by approving Vattenfall's acquisition of three regional utilities, other market participants raised concerns over the emergence of an upcoming oligopoly in the German market for power generation. We contrast the efficiency hypothesis postulating pro-competitive effects of mergers with the market power hypothesis postulating anti-competitive effects. For the analysis of the two opposing hypotheses, we use an event study approach to the stock prices of Vattenfall's competitors in the German market. While we find no empirical evidence for increased market power in the German electricity market due to Vattenfall's mergers, there is some indication for efficiency increases. We therefore cannot oppose the view of the competition authorities predicting an overall positive effect for consumers as a result of Vattenfall's entry into the German electricity market.

76 FR 67004 - Order Approving Filing Fees for Exempt Reporting Advisers and Private Fund Advisers

Science.gov (United States)

2011-10-28

... billion or more in hedge fund assets, combined liquidity fund and registered money market fund assets or...] Order Approving Filing Fees for Exempt Reporting Advisers and Private Fund Advisers Section 204(c) of... funds (a ``private fund adviser'') to file proposed Form PF on a periodic basis.\\2\\ On September 30...

Strategic market segmentation

Directory of Open Access Journals (Sweden)

Maričić Branko R.

2015-01-01

Full Text Available Strategic planning of marketing activities is the basis of business success in modern business environment. Customers are not homogenous in their preferences and expectations. Formulating an adequate marketing strategy, focused on realization of company's strategic objectives, requires segmented approach to the market that appreciates differences in expectations and preferences of customers. One of significant activities in strategic planning of marketing activities is market segmentation. Strategic planning imposes a need to plan marketing activities according to strategically important segments on the long term basis. At the same time, there is a need to revise and adapt marketing activities on the short term basis. There are number of criteria based on which market segmentation is performed. The paper will consider effectiveness and efficiency of different market segmentation criteria based on empirical research of customer expectations and preferences. The analysis will include traditional criteria and criteria based on behavioral model. The research implications will be analyzed from the perspective of selection of the most adequate market segmentation criteria in strategic planning of marketing activities.

77 FR 52097 - Self-Regulatory Organizations; EDGA Exchange, Inc.; Order Approving a Proposed Rule Change, as...

Science.gov (United States)

2012-08-28

... financial and regulatory risk management controls and supervisory procedures required by Rule 15c3-5 under...-Regulatory Organizations; EDGA Exchange, Inc.; Order Approving a Proposed Rule Change, as Modified by... that broker-dealers appropriately control the risks associated with market access, so as not to...

Market-based implementation of Kyoto commitments: how the financial/insurance sector can support industry

International Nuclear Information System (INIS)

Knoepfel, Ivo

1999-01-01

The implementation of the Kyoto Protocol in the context of the Framework Convention on Climate Change will probably lead to economic winners and losers in various sectors of the economy. Especially carbon intensive industries will need to develop hedging strategies to prevent potential negative effects and to optimise market opportunities. Such strategies can be based on technological innovation, market and product diversification, and on financial/legal offsets. The Kyoto Protocol has introduced new market-based instruments, which can, in a near future provide such hedging opportunities. These include joint implementation, the so-called clean development mechanism, and international emissions trading. The financial services and insurance sector are the natural partners of industry in designing tailored hedging strategies. It is recommended that industry, financial services and insurance companies take a more proactive role in further developing the market-based instruments established by the Kyoto Protocol. (Author)

77 FR 48148 - Energy Alternatives Wholesale, LLC; Supplemental Notice That Initial Market-Based Rate Filing...

Science.gov (United States)

2012-08-13

... Energy Alternatives Wholesale, LLC's application for market-based rate authority, with an accompanying... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. ER12-2413-000] Energy Alternatives Wholesale, LLC; Supplemental Notice That Initial Market-Based Rate Filing Includes Request for...

76 FR 6128 - Energy Exchange International, LLC; Supplemental Notice That Initial Market-Based Rate Filing...

Science.gov (United States)

2011-02-03

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. ER11-2730-000] Energy Exchange International, LLC; Supplemental Notice That Initial Market-Based Rate Filing Includes Request for... proceeding Energy Exchange International, LLC's application for market-based rate authority, with an...

77 FR 52016 - Brookfield Smoky Mountain Hydropower LLC; Supplemental Notice That Initial Market-Based Rate...

Science.gov (United States)

2012-08-28

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. ER12-2447-001] Brookfield Smoky Mountain Hydropower LLC; Supplemental Notice That Initial Market-Based Rate Filing Includes... proceeding, of Brookfield Smoky Mountain Hydropower LLC's application for market- based rate authority, with...

Market-based process and product innovation in the food sector: A Danish research programme

DEFF Research Database (Denmark)

Grunert, Klaus G.; Baadsgaard, Allan

1992-01-01

This note informs about the Danish MAPP research programme, a collection of 15 research projects aimed at making product and process innovation in the food sector more market-based. The programme, which has an interdisciplinary base, but is geared towards marketing applications, is concerned...... with the organization of the innovation process, the interaction of consumer and producer criteria in product development, the assessment of long-term developments in the market environment and the role distribution system in product innovation. Innovation in both primary production and processing are considered....

Does Increased Spending on Pharmaceutical Marketing Inhibit Pioneering Innovation?

Science.gov (United States)

Arnold, Denis G; Troyer, Jennifer L

2016-04-01

The pharmaceutical industry has been criticized for developing and aggressively marketing drugs that do not provide significant health benefits relative to existing drugs but retain the benefits of patent protection. Critics argue that drug marketing increases health care expenditures and provides a disincentive for pioneering drug innovation. However, evidence that marketing expenditures have any relationship to new drug approvals has been anecdotal. We hypothesized that, at publicly traded pharmaceutical firms, increased marketing expenditures will result in a reduced volume of pioneering new drugs in comparison to less innovative new drugs. We also hypothesized that additional research and development spending will result in an increased volume of pioneering new drugs in comparison to less innovative drugs. Results confirm our hypotheses. Specific policy recommendations for altering firms' incentives for the development of pioneering drugs are provided. Copyright © 2016 by Duke University Press.

76 FR 1889 - Risk-Based Capital Guidelines: Market Risk

Science.gov (United States)

2011-01-11

... ``three-pillar'' framework that includes (i) risk-based capital requirements for credit risk, market risk... incremental risk capital requirement to capture default and credit quality migration risk for non... (advanced approaches rules) (collectively, the credit risk capital rules) \\8\\ by requiring any bank subject...

Micro Mobility Marketing

DEFF Research Database (Denmark)

Hosbond, Jens Henrik; Skov, Mikael B.

2008-01-01

, in our case a medium-sized retail supermarket. Two prototypes based on push and pull marketing strategies are implemented and evaluated. Taking outset in a synthesis of central issues in contemporary research on mobile marketing, we discuss their role in micro mobility marketing to point to similarities......Mobile marketing refers to marketing of services or goods using mobile technology and mobile marketing holds potentially great economical opportunities. Traditionally, mobile marketing has been viewed as mobility in the large taking place virtually anywhere, anytime. Further, research shows...... considerable number of studies on push-based SMS mobile marketing campaigns. This paper explores a related yet different form of mobile marketing namely micro mobility marketing. Micro mobility marketing denotes mobility in the small, meaning that promotion of goods takes place within a circumscribed location...

Do Internet Credit Markets Improve Access to Credit for Female Business Owners?

OpenAIRE

Barasinska, Nataliya; Schäfer, Dorothea

2010-01-01

Business owners and founders are a minority of any bank's business clients. Scientific studies of traditional credit markets often show a lower probability of loan approval or higher loan costs for female business owners compared to male business owners. With this background the question arises whether female business owners have to struggle with this problem less on Internet credit markets. In this current study, DIW Berlin investigated business loans on the largest German Internet platform,...

Research on energy stock market associated network structure based on financial indicators

Science.gov (United States)

Xi, Xian; An, Haizhong

2018-01-01

A financial market is a complex system consisting of many interacting units. In general, due to the various types of information exchange within the industry, there is a relationship between the stocks that can reveal their clear structural characteristics. Complex network methods are powerful tools for studying the internal structure and function of the stock market, which allows us to better understand the stock market. Applying complex network methodology, a stock associated network model based on financial indicators is created. Accordingly, we set threshold value and use modularity to detect the community network, and we analyze the network structure and community cluster characteristics of different threshold situations. The study finds that the threshold value of 0.7 is the abrupt change point of the network. At the same time, as the threshold value increases, the independence of the community strengthens. This study provides a method of researching stock market based on the financial indicators, exploring the structural similarity of financial indicators of stocks. Also, it provides guidance for investment and corporate financial management.

PERCEPTION OF TOURISTS TOWARD COMMUNITY-BASED FESTIVAL OF KUTA MAJELANGU MARKET

Directory of Open Access Journals (Sweden)

Made Ruki

2017-12-01

Full Text Available The aim of this research was to identify foreign tourist perception toward service of KutaMajelangu Market as an Attraction of community-based tourism. Foreign tourist’s perception was analyzed by Likert scale. This research used various approaches such as: social and culture, community based tourism, sustainable tourism, and perception theory. Respondents were taken from foreign tourist come from many  countries such as Japan, Australia, China, America, Germany, Austria, Holland, and British, while the informants were taken from districts officers, around Kuta Village: such as the head of traditional village known as bendesa, head od subvillage/kelihan banjar,  and Kuta community leaders. Data were taken from observation, Interview, questionnaire, and some documents. The results of this study revealed that perception of tourists toward the festival Market Majelangu Kuta as community-based tourist attraction for a variety of requirements had been fulfillment where starting from the land use, planning, management, preservation, benefit economically performed independently by local community. While the perception of tourists toward the activities and services of the Market Majelangu Kuta were well perceived by 79% percent of tourists

76 FR 29680 - Approval and Disapproval and Promulgation of State Implementation Plan Revisions; Infrastructure...

Science.gov (United States)

2011-05-23

..., marketable permits, and auctions of emissions rights), as well as schedules and timetables for compliance as...) program as required by part C of the Act, and the State's minor NSR program as required by 110(a)(2)(C...), respectively. Minor NSR Finally, with regards to minor NSR, in this action EPA is proposing to approve Wyoming...

Time delay and profit accumulation effect on a mine-based uranium market clearing model

International Nuclear Information System (INIS)

Auzans, Aris; Teder, Allan; Tkaczyk, Alan H.

2016-01-01

Highlights: • Improved version of a mine-based uranium market clearing model for the front-end uranium market and enrichment industries is proposed. • A profit accumulation algorithm and time delay function provides more realistic uranium mine decision making process. • Operational decision delay increased uranium market price volatility. - Abstract: The mining industry faces a number of challenges such as market volatility, investment safety, issues surrounding employment and productivity. Therefore, computer simulations are highly relevant in order to reduce financial risks associated with these challenges. In the mining industry, each firm must compete with other mines and the basic target is profit maximization. The aim of this paper is to evaluate the world uranium (U) supply by simulating financial management challenges faced by an individual U mine that are caused by a variety of regulation issues. In this paper front-end nuclear fuel cycle tool is used to simulate market conditions and the effects they have on the stability of U supply. An individual U mine’s exit or entry in the market might cause changes in the U supply side which can increase or decrease the market price. In this paper we offer a more advanced version of a mine-based U market clearing model. The existing U market model incorporates the market of primary U from uranium mines with secondary uranium (depleted uranium DU), enriched uranium (HEU) and enrichment services. In the model each uranium mine acts as an independent agent that is able to make operational decisions based on the market price. This paper introduces a more realistic decision making algorithm of individual U mine that adds constraints to production decisions. The authors added an accumulated profit model, which allows for the profits accumulated to cover any possible future economic losses and the time-delay algorithm to simulate delayed process of reopening a U mine. The U market simulation covers time period 2010

Time delay and profit accumulation effect on a mine-based uranium market clearing model

Energy Technology Data Exchange (ETDEWEB)

Auzans, Aris [Institute of Physics, University of Tartu, Ostwaldi 1, EE-50411 Tartu (Estonia); Teder, Allan [School of Economics and Business Administration, University of Tartu, Narva mnt 4, EE-51009 Tartu (Estonia); Tkaczyk, Alan H., E-mail: alan@ut.ee [Institute of Physics, University of Tartu, Ostwaldi 1, EE-50411 Tartu (Estonia)

2016-12-15

Highlights: • Improved version of a mine-based uranium market clearing model for the front-end uranium market and enrichment industries is proposed. • A profit accumulation algorithm and time delay function provides more realistic uranium mine decision making process. • Operational decision delay increased uranium market price volatility. - Abstract: The mining industry faces a number of challenges such as market volatility, investment safety, issues surrounding employment and productivity. Therefore, computer simulations are highly relevant in order to reduce financial risks associated with these challenges. In the mining industry, each firm must compete with other mines and the basic target is profit maximization. The aim of this paper is to evaluate the world uranium (U) supply by simulating financial management challenges faced by an individual U mine that are caused by a variety of regulation issues. In this paper front-end nuclear fuel cycle tool is used to simulate market conditions and the effects they have on the stability of U supply. An individual U mine’s exit or entry in the market might cause changes in the U supply side which can increase or decrease the market price. In this paper we offer a more advanced version of a mine-based U market clearing model. The existing U market model incorporates the market of primary U from uranium mines with secondary uranium (depleted uranium DU), enriched uranium (HEU) and enrichment services. In the model each uranium mine acts as an independent agent that is able to make operational decisions based on the market price. This paper introduces a more realistic decision making algorithm of individual U mine that adds constraints to production decisions. The authors added an accumulated profit model, which allows for the profits accumulated to cover any possible future economic losses and the time-delay algorithm to simulate delayed process of reopening a U mine. The U market simulation covers time period 2010

Institutional bases of the advertising market

Directory of Open Access Journals (Sweden)

К.В. Кузьменко

2005-03-01

Full Text Available  The article grounds a necessity of  organizational power of a “contract state” for the introduction and functioning of the norms of market constitution, it consists findings of the investigations of Ukrainian state’s typology. The institutional analysis of budget items has been used for the purpose of estimation the digree of approximation to the model of “contract state”. “Contract” state and the norms of market constitution are the indispensable conditions for the development of advertising market.

A Reappraisal on Marketing Definition and Marketing Theory

OpenAIRE

Ran Liu

2017-01-01

This study examines the definition of marketing and different marketing theories for academic research based on historical literature review. After a comprehensive review on different approaches on marketing definition, the paper gives its own description of marketing, with a highlight on value creation and exchange. The paper also attempts to discuss the possibility that a potential new paradigm of marketing as a science by a value creation theory, which focus on the new role of marketing in...

78 FR 28214 - Gainesville Renewable Energy Center, LLC; Supplemental Notice That Initial Market-Based Rate...

Science.gov (United States)

2013-05-14

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. ER13-1348-000] Gainesville Renewable Energy Center, LLC; Supplemental Notice That Initial Market-Based Rate Filing Includes Request for... Gainesville Renewable Energy Center, LLC's application for market- based rate authority, with an accompanying...

78 FR 40473 - Plainfield Renewable Energy, LLC; Supplemental Notice That Initial Market-Based Rate Filing...

Science.gov (United States)

2013-07-05

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. ER13-1734-000] Plainfield Renewable Energy, LLC; Supplemental Notice That Initial Market-Based Rate Filing Includes Request for... Plainfield Renewable Energy, LLC's application for market-based rate authority, with an accompanying rate...

77 FR 64980 - Chesapeake Renewable Energy LLC; Supplemental Notice That Initial Market-Based Rate Filing...

Science.gov (United States)

2012-10-24

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. ER13-28-000] Chesapeake Renewable Energy LLC; Supplemental Notice That Initial Market-Based Rate Filing Includes Request for Blanket... proceeding of Chesapeake Renewable Energy LLC's application for market-based rate authority, with an...

77 FR 9226 - Physical Systems Integration, LLC; Supplemental Notice That Initial Market-Based Rate Filing...

Science.gov (United States)

2012-02-16

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. ER12-1013-000] Physical Systems Integration, LLC; Supplemental Notice That Initial Market-Based Rate Filing Includes Request for... Physical Systems Integration, LLC's application for market-based rate authority, with an accompanying rate...

75 FR 41855 - Stream Energy Pennsylvania, LLC; Supplemental Notice That Initial Market-Based Rate Filing...

Science.gov (United States)

2010-07-19

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. ER10-1750-000] Stream Energy Pennsylvania, LLC; Supplemental Notice That Initial Market-Based Rate Filing Includes Request for Blanket... of Stream Energy Pennsylvania, LLC's application for market-based rate authority, with an...

75 FR 61747 - Union Leader Corporation; Supplemental Notice That Initial Market-Based Rate Filing Includes...

Science.gov (United States)

2010-10-06

... of Union Leader Corporation's application for market-based rate authority, with an accompanying rate... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. ER10-2780-000] Union Leader Corporation; Supplemental Notice That Initial Market-Based Rate Filing Includes Request for Blanket Section...

77 FR 42722 - Berry Petroleum Company; Supplemental Notice That Initial Market-Based Rate Filing Includes...

Science.gov (United States)

2012-07-20

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. ER12-2233-000] Berry Petroleum Company; Supplemental Notice That Initial Market-Based Rate Filing Includes Request for Blanket... Petroleum Company's application for market-based rate authority, with an accompanying rate schedule, noting...

SIMULATING AN EVOLUTIONARY MULTI-AGENT BASED MODEL OF THE STOCK MARKET

Directory of Open Access Journals (Sweden)

Diana MARICA

2015-08-01

Full Text Available The paper focuses on artificial stock market simulations using a multi-agent model incorporating 2,000 heterogeneous agents interacting on the artificial market. The agents interaction is due to trading activity on the market through a call auction trading mechanism. The multi-agent model uses evolutionary techniques such as genetic programming in order to generate an adaptive and evolving population of agents. Each artificial agent is endowed with wealth and a genetic programming induced trading strategy. The trading strategy evolves and adapts to the new market conditions through a process called breeding, which implies that at each simulation step, new agents with better trading strategies are generated by the model, from recombining the best performing trading strategies and replacing the agents which have the worst performing trading strategies. The simulation model was build with the help of the simulation software Altreva Adaptive Modeler which offers a suitable platform for financial market simulations of evolutionary agent based models, the S&P500 composite index being used as a benchmark for the simulation results.

75 FR 38072 - Notice of a Request for Extension of a Currently Approved Information Collection

Science.gov (United States)

2010-07-01

... sales transactions, the type and class of commodity, the marketing year of shipment, and the destination... destination or 200,000 tons or more of one commodity during the weekly reporting period. Large sales for... destinations. The estimated total annual burden of 42,947 hours in the OMB inventory for the currently approved...

The influence of relationship marketing drivers on marketing and business performance

OpenAIRE

Cristian DUTU

2012-01-01

In the last few decades, both marketing theory and practice have gone through a transformation process, from the approach based on the marketing mix concept (the traditional/transactional approach in marketing) to a relationship-based approach. As a strategic orientation, relationship marketing requires a focus on maintaining and developing profitable long-term relationships with customers. As a as a result of the organization's focus on relationship marketing customer satisfaction has receiv...

First Approval of Improved Medical Device Conditional on Use-Result Survey in Japan　- Regulatory Review of Polymer-Free Drug-Coated BioFreedom Coronary Stent.

Science.gov (United States)

Konishi, Akihide; Ho, Mami; Shirai, Yuko; Shirato, Haruki

2018-05-25

A prospective randomized clinical trial showed that the BioFreedom stent (Biosensors International), which is a polymer-free and carrier-free drug-coated stent, was significantly superior to a bare-metal stent (BMS) in patients at high bleeding risk who were receiving a 1-month course of dual antiplatelet therapy (DAPT). However, the stent thrombosis rate (2.01% for BioFreedom vs. 2.20% for BMS) was 4-6-fold higher than that of approved drug-eluting stents based on real-world data in Japan. Furthermore, the frequency of stent thrombosis at more than 1 month with the BioFreedom stent was slightly higher than that at less than 1 month. This result suggested that it would not be acceptable to stop DAPT universally at 1 month. Thus, the target patients for the BioFreedom stent are unspecified patients at high bleeding risk needing to continue DAPT for as long as necessary in Japan. Therefore, based on the pre- and post-marketing balance of medical devices regulations, regulatory approval was given for unspecified patients conditionally upon real-world data collection of 2,000 patients with a Use-Results Survey, instead of conducting additional pre-marketing clinical trial(s). The Use-Results Survey System is part of a strategy to expedite patients' access to innovative medical devices and to accelerate the development of medical devices.

77 FR 66432 - Request for Extension and Revision of a Currently Approved Information Collection for the...

Science.gov (United States)

2012-11-05

... opportunity to develop a personal relationship with their customers; and cultivate consumer loyalty with the... Management and Budget, for an extension of and revision to the currently approved information collection for... affiliated with a farm where transactions between a farm market operator and customers take place. A farm...

76 FR 38601 - Notice of Request for Extension of Approval of an Information Collection; Self-Certification...

Science.gov (United States)

2011-07-01

... approval of an information collection. Abstract: The Marketing and Regulatory Programs (MRP) agencies of.... agricultural products and protect the health of domestic animal and plant resources. The MRP agencies are the... human resource management, for the three MRP agencies are provided by the MRP Business Services unit of...

75 FR 74711 - Planet Energy (Pennsylvania) Corp.; Supplemental Notice That Initial Market-Based Rate Filing...

Science.gov (United States)

2010-12-01

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. ER11-2167-000] Planet Energy (Pennsylvania) Corp.; Supplemental Notice That Initial Market-Based Rate Filing Includes Request for Blanket... proceeding, of Planet Energy (Pennsylvania) Corp.'s application for market-based rate authority, with an...

75 FR 74712 - Planet Energy (Maryland) Corp.; Supplemental Notice That Initial Market-Based Rate Filing...

Science.gov (United States)

2010-12-01

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. ER11-2168-000] Planet Energy (Maryland) Corp.; Supplemental Notice That Initial Market-Based Rate Filing Includes Request for Blanket... proceeding, of Planet Energy (Maryland) Corp.'s application for market-based rate authority, with an...

76 FR 12726 - Tropicana Manufacturing Company, Inc.; Supplemental Notice That Initial Market-Based Rate Filing...

Science.gov (United States)

2011-03-08

... . To facilitate electronic service, persons with Internet access who will eFile a document and/or be... Manufacturing Company, Inc.; Supplemental Notice That Initial Market-Based Rate Filing Includes Request for... Tropicana Manufacturing Company, Inc.'s application for market-based rate authority, with an accompanying...

Market-based approach to financial architecture

NARCIS (Netherlands)

Underhill, G.R.D.; Caprio, G.; Beck, T.; Claessens, S.; Schmukler, S.L.

2013-01-01

The institutions of financial governance are central to the prospects for financial stability. Without sound regulatory and supervisory institutions, herd behavior and market failure looms large in a liberal financial system. Cross-border and cross-sectoral financial market integration exacerbates

77 FR 7166 - Draft Guidance for Industry on Determining the Extent of Safety Data Collection Needed in Late...

Science.gov (United States)

2012-02-10

... late in the development of a drug for marketing approval or after approval based on what is already... investigational drugs to support marketing approval (premarket) and trials conducted after approval (postmarket... assessment without compromising the integrity of the trial results. DATES: Although you can comment on any...

Combined hydro-wind generation bids in a pool-based electricity market

International Nuclear Information System (INIS)

Angarita, Jorge L.; Usaola, Julio; Martinez-Crespo, Jorge

2009-01-01

Present regulatory trends are promoting the direct participation of wind energy in electricity markets. The final result of these markets sets the production scheduling for the operation time, including a power commitment from the wind generators. However, wind resources are uncertain, and the final power delivered usually differs from the initial power committed. This imbalance produces an overcost in the system, which must be paid by those who produce it, e.g., wind generators among others. As a result, wind farm revenue decreases, but it could increase by allowing wind farms to submit their bids to the markets together with a hydro generating unit, which may easily modify its production according to the expected imbalance. This paper presents a stochastic optimization technique that maximizes the joint profit of hydro and wind generators in a pool-based electricity market, taking into account the uncertainty of wind power prediction. (author)

Behavioral Finance and Agent-Based Artificial Markets

NARCIS (Netherlands)

M. Lovric (Milan)

2011-01-01

textabstractStudying the behavior of market participants is important due to its potential impact on asset prices and the dynamics of financial markets. The idea of individual investors who are prone to biases in judgment and who use various heuristics, which might lead to anomalies on the market

Impact of the market premium on direct marketers. An agency-based model approach; Auswirkungen der Marktpraemie auf die Akteure der Direktvermarktung. Ein agentenbasierter Modellansatz

Energy Technology Data Exchange (ETDEWEB)

Wassermann, Sandra; Hauser, Wolfgang [ZIRIUS Univ. Stuttgart (Germany); Reeg, Matthias [Deutsche Forschungsanstalt fuer Luft- und Raumfahrt e.V. (DLR), Stuttgart (Germany). Inst. fuer Technische Thermodynamik

2012-09-15

By introducing a market premium and tightening the eligibility requirements for the green electricity privilege, the latest amendment to the Renewable Energy Law (EEG) has brought about major changes to the market for direct marketing of electricity from EEG-eligible plants. Has the new EEG made direct marketing based on the green electricity privilege unprofitable altogether, or only for individual market participants? What are the experiences and perspectives of electricity traders in regard to the new EEG and what strategies and business models have they turned to as a result? This article presents first results from a project funded by the Ministry for Environment, Nature Conservation and Reactor Safety (BMU) on the impact of the new regulatory framework for direct marketing on businesses in the renewable electricity market.

Multiscale sample entropy and cross-sample entropy based on symbolic representation and similarity of stock markets

Science.gov (United States)

Wu, Yue; Shang, Pengjian; Li, Yilong

2018-03-01

A modified multiscale sample entropy measure based on symbolic representation and similarity (MSEBSS) is proposed in this paper to research the complexity of stock markets. The modified algorithm reduces the probability of inducing undefined entropies and is confirmed to be robust to strong noise. Considering the validity and accuracy, MSEBSS is more reliable than Multiscale entropy (MSE) for time series mingled with much noise like financial time series. We apply MSEBSS to financial markets and results show American stock markets have the lowest complexity compared with European and Asian markets. There are exceptions to the regularity that stock markets show a decreasing complexity over the time scale, indicating a periodicity at certain scales. Based on MSEBSS, we introduce the modified multiscale cross-sample entropy measure based on symbolic representation and similarity (MCSEBSS) to consider the degree of the asynchrony between distinct time series. Stock markets from the same area have higher synchrony than those from different areas. And for stock markets having relative high synchrony, the entropy values will decrease with the increasing scale factor. While for stock markets having high asynchrony, the entropy values will not decrease with the increasing scale factor sometimes they tend to increase. So both MSEBSS and MCSEBSS are able to distinguish stock markets of different areas, and they are more helpful if used together for studying other features of financial time series.

Trends in global approvals of biotech crops (1992-2014).

Science.gov (United States)

Aldemita, Rhodora R; Reaño, Ian Mari E; Solis, Renando O; Hautea, Randy A

2015-01-01

With the increasing number of genetically modified (GM) events, traits, and crops that are developed to benefit the global population, approval of these technologies for food, feed, cultivation and import in each country may vary depending on needs, demand and trade interest. ISAAA established a GMO Approval Database to document global approvals of biotech crops. GM event name, crops, traits, developer, year of approval for cultivation, food/feed, import, and relevant dossiers were sourced from credible government regulatory websites and biosafety clearinghouses. This paper investigates the trends in GM approvals for food, feed and cultivation based on the number of approving countries, GM crops, events, and traits in the last 23 y (1992-2014), rationale for approval, factors influencing approvals, and their implications in GM crop adoption. Results show that in 2014, there was an accumulative increase in the number of countries granting approvals at 29 (79% developing countries) for commercial cultivation and 31 (70% developing countries) for food and 19 (80% developing developing) for feed; 2012 had the highest number of approving countries and cultivation approvals; 2011 had the highest number of country approvals for feed, and 2014 for food approvals. Herbicide tolerance trait had the highest events approved, followed by insect tolerance traits. Approvals for food product quality increased in the second decade. Maize had the highest number of events approved (single and stacked traits), and stacked traits product gradually increased which is already 30% of the total trait approvals. These results may indicate understanding and acceptance of countries to enhance regulatory capability to be able to benefit from GM crop commercialization. Hence, the paper provided information on the trends on the growth of the GM crop industry in the last 23 y which may be vital in predicting future GM crops and traits.

Project W-314 phase I environmental permits and approvals plan

International Nuclear Information System (INIS)

TOLLEFSON, K.S.

1999-01-01

This document describes the range of environmental actions, including required permits and other agency approvals, for Project W-314 activities in the Hanford Site's Tank Waste Remediation System. This document outlines alternative approaches to satisfying applicable environmental standards, and describes selected strategies for acquiring permits and other approvals needed for waste feed delivery to proceed. This document also includes estimated costs and schedule to obtain the required permits and approvals based on the selected strategy. It also provides estimated costs for environmental support during design and construction based on the preliminary project schedule provided

75 FR 28231 - Cotton Classification and Market News Service: Notice of Request for an Extension and Revision of...

Science.gov (United States)

2010-05-20

... DEPARTMENT OF AGRICULTURE Agricultural Marketing Service [AMS-CN-10-0037; CN-10-003] Cotton....regulations.gov. All comments should reference the docket number and page number of this issue of the Federal... and Market News Service. OMB Number: 0581-0009. Expiration Date of Approval: December 30, 2010. Type...

E-mail marketing

OpenAIRE

TŮMOVÁ, Kateřina

2012-01-01

The aim of this work is to specify the e-mail marketing and in the practical application to evaluate the pros and cons of e-mail marketing as a tool of targeted marketing communication.Based on personal interviews with representatives of the company was described their existing e-mail marketing.Through the survey it was found, how customers perceive the company's e-mail marketing.Based on the survey, changes were proposed at the end of the thesis.

Using Web-Based Foreign Advertisements in International Marketing Classes

Science.gov (United States)

Ryan, Jason

2011-01-01

The author examines the use of the Web-based foreign advertisements for enhancing the international awareness of undergraduate marketing students. An analysis compares the adaptation of advertisements for identical products to the cultural perceptions and values of consumers in different countries. In a sample of 110 international marketing…

How Feedback Can Improve Managerial Evaluations of Model-based Marketing Decision Support Systems

NARCIS (Netherlands)

U. Kayande (Ujwal); A. de Bruyn (Arnoud); G.L. Lilien (Gary); A. Rangaswamy (Arvind); G.H. van Bruggen (Gerrit)

2006-01-01

textabstractMarketing managers often provide much poorer evaluations of model-based marketing decision support systems (MDSSs) than are warranted by the objective performance of those systems. We show that a reason for this discrepant evaluation may be that MDSSs are often not designed to help users

The approval process for biosimilar erythropoiesis-stimulating agents.

Science.gov (United States)

Wish, Jay B

2014-09-05

A biosimilar drug or follow-on biologic drug is defined by the Public Health Service Act as a product that is "highly similar to the reference product notwithstanding minor differences in clinically active components and there are no clinically meaningful differences between the biologic product and the reference product in terms of the safety, purity and potency of the product." The advantage of biosimilar drugs is that they are significantly less expensive than the reference products, allowing for increased accessibility and cost savings. Recognizing these advantages, the US Congress passed the Biologics Price Competition and Innovation Act in 2009 as part of health care reform. The Biologics Price Competition and Innovation Act allows sponsors of biosimilar agents to seek approval by showing structural and functional similarity to the reference agent, with the extent of required clinical studies to be determined on the basis of the degree of biosimilarity with the reference product. The goal is to bring biosimilar agents to the market more efficiently while still protecting the safety of the public. The European Union has had such a process in place for a number of years. Two biosimilar epoetin agents have been approved in the European Union since 2007, and their companies are conducting trials to seek approval in the United States, because Amgen's patent protection for epoetin alfa expires in 2014. Trials completed for European Union approval of both agents showed similar efficacy and safety to the reference epoetin alfa. As with all biologics, immunogenicity concerns may persist because of the fragility of the manufacturing process and the worldwide experience with pure red cell aplasia as a result of epoetin therapy. The uptake of biosimilar epoetins after approval in the United States will depend on the balance of cost advantage against safety concerns. Competition in the marketplace will likely decrease the cost of the reference agent as well. Copyright �

New Brunswick Market Design Committee : market design issues paper : choice of market model

International Nuclear Information System (INIS)

2001-01-01

A model for the competitive electricity market in New Brunswick was not specified by the White Paper: New Brunswick Energy Policy, published in March 2001. One of the tasks of the Market Design Committee (MDC) is to select a market model for the province. This report was prepared with this objective in mind. It begins by providing a description of the basic functions that must be performed by any electricity system. Different market models will function differently, and a descriptions of how the functions would be performed under each model is presented. Considering the specific size and geographic location of New Brunswick, a number of actual markets that could be of interest are presented. The various electricity markets normally use one of four market models: vertically integrated monopoly utility, a competitive pool market, a bilateral contract market, and a single-buyer market. The first model was not explained as it represents the existing, non-competitive model whereby the government owns and/or regulates price and investment decision. The case where a market operator receives bids and offers from buyers and sellers and matches them to derive a price and schedule for the spot market is what is called the competitive pool market. When electricity trade takes place through a series of contracts between individual buyers and sellers, it is referred to as a bilateral contract market. Finally, the single-buyer market is defined as a monopoly where the buyer purchases from multiple sellers based on competition amongst them. Different examples are provided of applications of the three markets described in the paper. Both New England and New Zealand were chosen to better illustrate the concepts of a fully competitive pool-based market, as they either have close ties to New Brunswick, or share physical similarities. The single-buyer model is illustrated by the case of Northern Ireland where size is similar. The choices made in Quebec were described in the final

One Size (Never) Fits All: Segment Differences Observed Following a School-Based Alcohol Social Marketing Program

Science.gov (United States)

Dietrich, Timo; Rundle-Thiele, Sharyn; Leo, Cheryl; Connor, Jason

2015-01-01

Background: According to commercial marketing theory, a market orientation leads to improved performance. Drawing on the social marketing principles of segmentation and audience research, the current study seeks to identify segments to examine responses to a school-based alcohol social marketing program. Methods: A sample of 371 year 10 students…

The legal and economic forces that will shape the international market for cybersurgery.

Science.gov (United States)

McLean, Thomas R

2006-12-01

Despite the common use of medical devices most health care providers have little understanding how a device alters medical malpractice litigation. Such knowledge will be increasingly valuable as cybersurgery (i.e. remote robotic surgery) becomes routine. Review of the laws governing products and telecommunication liability. Litigation after cybersurgery will be complex. In addition to being able to sue physicians and hospitals, patients who sustain an adverse outcome after cybersurgery will have the potential to sue the robotic manufacturer and telecommunication company. Robotics manufacturers can obtain virtual immunity from liability if they elected to place their devices on the market after obtaining [see text]360 per-market approval from the FDA. However, because [see text]360 pre-market approval is expensive and time consuming most medical devices on the market (including the robotic surgical instruments) do not have immunity to products liability. Consequently, after an adverse cybersurgical outcome a manufacturer of a robotic surgical instrument faces liability for failure to warn, design defects, and failure to properly manufacture. As for telecommunication providers, existing law provides them with immunity from liability. Litigation following cybersurgery will involve multiple defendants who are likely to use "finger pointing" defenses. Accordingly, there will be liability traps associated with providing cybersurgery. Copyright 2006 John Wiley & Sons, Ltd.

77 FR 35455 - Self-Regulatory Organizations; New York Stock Exchange LLC; Order Granting Approval of Proposed...

Science.gov (United States)

2012-06-13

...-Regulatory Organizations; New York Stock Exchange LLC; Order Granting Approval of Proposed Rule Change Amending NYSE Rule 107B To Add a Class of Supplemental Liquidity Providers That Are Registered as Market... proposed rule change to amend NYSE Rule 107B to add a class of Supplemental Liquidity Providers (``SLP...

An Examination of Market Entry Perspectives in Emerging Markets

Directory of Open Access Journals (Sweden)

Marvin O. Bates

2017-11-01

Full Text Available Purpose – The purpose of this article is to describe the marketing-oriented market entry approaches that businesses are currently using across the three levels of the world economic pyramid (i.e., WEP. These levels are the Top-tier, the Middle-tier, and the Base of the Pyramid-tier (i.e., BoP-tier. Methodology – The literature of the BoP was reviewed, and market entry approaches were itemized across the three WEP levels. Secondly, BoP strategic theorists including Prahalad identified the need for a BoP marketing focus replacing the traditional 4Ps marketing approach (i.e., Product, Price, Place and Promotion with the BoP-specific 4As marketing approach (i.e., Awareness, Affordability, Access and Availability. This 4As marketing approach is discussed. Findings – New marketing-oriented market-entry approaches are proposed for each of the three WEP levels. These approaches are based on where in the WEP the firm currently exists, and where in the WEP the firm desires to refocus market-entry activities; identified approaches include: inter-country expansion, intra-country entry, adjacent market entry, and extended market entry. Secondly, the absence of a clearly articulated marketing strategy for middle-tier markets was observed. Practical implications – This article has two specific applications. First, it summarizes the evolving market entry perspectives to provide a context for future market research in both emerging markets and the pre-emerging BoP markets. Second, the future requirement for an articulated marketing strategy for middle-tier markets is suggested. Originality – This article examined existing market entry approaches across all three levels of the WEP, inclusive of the BoP economic level. The language used to clarify market entry movements was extended, providing a specificity of description not previously found in either the existing market entry or BoP literature.

System of marketing deciding support based on game theory

Directory of Open Access Journals (Sweden)

Gordana Dukić

2008-12-01

Full Text Available Quantitative methods and models can be applied in numerous spheres of marketing deciding. The choice of optimal strategy in product advertising is one of the problems that the marketing-management often meets. The use of models developed within the framework of game theory makes significantly easier to find out the solutions of conflict situations that appear herewith. The system of deciding support presented in this work is based on the supposition that two opposed sides take part in the game. With the aim of deciding process promotion, the starting model incorporates computer simulation of percentile changes in the market share that represent elements of payment matrix. The supposition is that the random variables that represent them follow the normal division. It is necessary to carry out the evaluation of their parameters because of relevant data. Information techniques, computer and the adequate program applications take the special position in solving and analysis of the suggested model. This kind of their application represents the basic characteristic of the deciding support system.

Identity-based marketing : A new balanced marketing paradigm

NARCIS (Netherlands)

Alsem, K.J.; Kostelijk, E.J.

2008-01-01

Purpose - The purpose of this paper is to propose a fundamentally new extension of the marketing paradigm. This is theoretically and practically necessary since in the authors' view there is an insufficient balance between customer and brand thinking. Design/methodology/approach - While the

Medicare covers the majority of FDA-approved devices and Part B drugs, but restrictions and discrepancies remain.

Science.gov (United States)

Chambers, James D; May, Katherine E; Neumann, Peter J

2013-06-01

The Food and Drug Administration (FDA) and Medicare use different standards to determine, first, whether a new drug or medical device can be marketed to the public and, second, if the federal health insurance program will pay for use of the drug or device. This discrepancy creates hurdles and uncertainty for drug and device manufacturers. We analyzed discrepancies between FDA approval and Medicare national coverage determinations for sixty-nine devices and Part B drugs approved during 1999-2011. We found that Medicare covered FDA-approved drugs or devices 80 percent of the time. However, Medicare often added conditions beyond FDA approval, particularly for devices and most often restricting coverage to patients with the most severe disease. In some instances, Medicare was less restrictive than the FDA. Our findings highlight the importance for drug and device makers of anticipating Medicare's needs when conducting clinical studies to support their products. Our findings also provide important insights for the FDA's and Medicare's pilot parallel review program.

Reaching rural customers: the challenge of market-based rural electrification

Energy Technology Data Exchange (ETDEWEB)

Reinmueller, Dorothee [International Solar Energy Society (ISES), Freiburg (Germany); Adib, Rana [Fraunhofer Inst. for Solar Energy Systems ISE, Freiburg (Germany)

2002-06-01

The large number of households that need catering for in market based approaches to rural energy supply in developing countries makes different demands on all involved players: an extensive infrastructure for reaching the rural customer needs to be established, extensive investments have to be realised, financial sustainability must be assured, and the business must even show profit. Thus, for successful market and infrastructure development it is a major necessity to understand the mechanisms involved. The authors describe a new guide to assist governments, business, and financing organisations in providing energy to rural areas using renewables. (Author)

Reaching rural customers: the challenge of market-based rural electrification

International Nuclear Information System (INIS)

Reinmueller, Dorothee; Adib, Rana

2002-01-01

The large number of households that need catering for in market based approaches to rural energy supply in developing countries makes different demands on all involved players: an extensive infrastructure for reaching the rural customer needs to be established, extensive investments have to be realised, financial sustainability must be assured, and the business must even show profit. Thus, for successful market and infrastructure development it is a major necessity to understand the mechanisms involved. The authors describe a new guide to assist governments, business, and financing organisations in providing energy to rural areas using renewables. (Author)

Evolution of Web-based International Marketing

DEFF Research Database (Denmark)

Rask, Morten

2002-01-01

Companies that have been doing international business do not usually make the transition from traditional marketers to full-blown Web marketers in one sharp step. In our study of Danish firms, we found that in terms of the evolution of their Web strategies, these Danish companies went through three...

Understanding Financial Market States Using an Artificial Double Auction Market.

Science.gov (United States)

Yim, Kyubin; Oh, Gabjin; Kim, Seunghwan

2016-01-01

The ultimate value of theories describing the fundamental mechanisms behind asset prices in financial systems is reflected in the capacity of such theories to understand these systems. Although the models that explain the various states of financial markets offer substantial evidence from the fields of finance, mathematics, and even physics, previous theories that attempt to address the complexities of financial markets in full have been inadequate. We propose an artificial double auction market as an agent-based model to study the origin of complex states in financial markets by characterizing important parameters with an investment strategy that can cover the dynamics of the financial market. The investment strategies of chartist traders in response to new market information should reduce market stability based on the price fluctuations of risky assets. However, fundamentalist traders strategically submit orders based on fundamental value and, thereby stabilize the market. We construct a continuous double auction market and find that the market is controlled by the proportion of chartists, Pc. We show that mimicking the real state of financial markets, which emerges in real financial systems, is given within the range Pc = 0.40 to Pc = 0.85; however, we show that mimicking the efficient market hypothesis state can be generated with values less than Pc = 0.40. In particular, we observe that mimicking a market collapse state is created with values greater than Pc = 0.85, at which point a liquidity shortage occurs, and the phase transition behavior is described at Pc = 0.85.

Understanding Financial Market States Using an Artificial Double Auction Market.

Directory of Open Access Journals (Sweden)

Kyubin Yim

Full Text Available The ultimate value of theories describing the fundamental mechanisms behind asset prices in financial systems is reflected in the capacity of such theories to understand these systems. Although the models that explain the various states of financial markets offer substantial evidence from the fields of finance, mathematics, and even physics, previous theories that attempt to address the complexities of financial markets in full have been inadequate. We propose an artificial double auction market as an agent-based model to study the origin of complex states in financial markets by characterizing important parameters with an investment strategy that can cover the dynamics of the financial market. The investment strategies of chartist traders in response to new market information should reduce market stability based on the price fluctuations of risky assets. However, fundamentalist traders strategically submit orders based on fundamental value and, thereby stabilize the market. We construct a continuous double auction market and find that the market is controlled by the proportion of chartists, Pc. We show that mimicking the real state of financial markets, which emerges in real financial systems, is given within the range Pc = 0.40 to Pc = 0.85; however, we show that mimicking the efficient market hypothesis state can be generated with values less than Pc = 0.40. In particular, we observe that mimicking a market collapse state is created with values greater than Pc = 0.85, at which point a liquidity shortage occurs, and the phase transition behavior is described at Pc = 0.85.

The limits of evidence in drug approval and availability: a case study of cilostazol and naftidrofuryl for the treatment of intermittent claudication.

Science.gov (United States)

Hong, Haeyeon; Mackey, William C

2014-08-01

Despite numerous efforts to develop effective medications for the treatment of intermittent claudication (IC) over the past 4 decades, a gold standard medical management option has yet to be defined. Although not life-threatening, IC interferes with mobility and activities of daily living, significantly impairing quality of life and potentially causing depression. Cilostazol, the leading pharmacologic agent for IC in the United States, was approved by the US Food and Drug Administration (FDA) in 1999 based on controversial data. Meanwhile, naftidrofuryl, the first-line pharmacologic agent for IC in the United Kingdom and Europe, has never been approved by the FDA and therefore is not available in the United States. The clinical data for cilostazol and naftidrofuryl are plagued by flaws related to lack of protocol standardization, objective endpoints, and strict eligibility criteria in study subjects, making identification of a true treatment effect impossible. Furthermore, no prospective randomized trial comparing the efficacy of cilostazol and naftidrofuryl has been conducted, because the manufacturers of these agents have much to lose and little to gain from such a study. This article provides an overview of the pharmacology of cilostazol and naftidrofuryl, and the clinical studies leading to their approval and clinical acceptance. It further explores the possible sources of bias in analyzing these clinical trials, some of which have been brought to light by the National Institute for Health and Clinical Excellence (NICE) of the United Kingdom in its technology appraisal guidance. It also speculates the ways in which economic incentives may affect drug-marketing decisions. A literature review of pharmacology and clinical trials for cilostazol and naftidrofuryl was performed in PubMed. The majority of included clinical trials were initially identified through the most recent Cochrane review articles as well as the FDA's approval packet for cilostazol. The

Evaluation of wholesale electric power market rules and financial risk management by agent-based simulations

Science.gov (United States)

Yu, Nanpeng

As U.S. regional electricity markets continue to refine their market structures, designs and rules of operation in various ways, two critical issues are emerging. First, although much experience has been gained and costly and valuable lessons have been learned, there is still a lack of a systematic platform for evaluation of the impact of a new market design from both engineering and economic points of view. Second, the transition from a monopoly paradigm characterized by a guaranteed rate of return to a competitive market created various unfamiliar financial risks for various market participants, especially for the Investor Owned Utilities (IOUs) and Independent Power Producers (IPPs). This dissertation uses agent-based simulation methods to tackle the market rules evaluation and financial risk management problems. The California energy crisis in 2000-01 showed what could happen to an electricity market if it did not go through a comprehensive and rigorous testing before its implementation. Due to the complexity of the market structure, strategic interaction between the participants, and the underlying physics, it is difficult to fully evaluate the implications of potential changes to market rules. This dissertation presents a flexible and integrative method to assess market designs through agent-based simulations. Realistic simulation scenarios on a 225-bus system are constructed for evaluation of the proposed PJM-like market power mitigation rules of the California electricity market. Simulation results show that in the absence of market power mitigation, generation company (GenCo) agents facilitated by Q-learning are able to exploit the market flaws and make significantly higher profits relative to the competitive benchmark. The incorporation of PJM-like local market power mitigation rules is shown to be effective in suppressing the exercise of market power. The importance of financial risk management is exemplified by the recent financial crisis. In this

LULUCF-based CDM. Too much ado for a small carbon market

International Nuclear Information System (INIS)

Bernoux, M.; Feller, C.; Eschenbrenner, V.; Cerri, C.C.; Melillo, J.M.

2002-01-01

The Bonn agreement reached in July at the sixth conference of the parties (COP) to the FCCC states 'that for the first commitment period, the total of additions to and subtractions from the assigned amount of a party resulting from eligible LULUCF activities under Article 12 (i.e. CDM), shall not exceed 1% of base-year emissions of that party, times five'. The most probable size of this LULUCF-CDM (land use, land-use change and forestry - clean development mechanism) market is analyzed in light of each Annex I party's actual and projected emissions and policies. Results show that the market size would be only about 110 Mt CO2 eq. for 2000-2012, representing a maximum global market value of about US$ 876 million

REVIEW OF NRC APPROVED DIGITAL CONTROL SYSTEMS ANALYSIS

International Nuclear Information System (INIS)

Markman, D.W.

1999-01-01

Preliminary design concepts for the proposed Subsurface Repository at Yucca Mountain indicate extensive reliance on modern, computer-based, digital control technologies. The purpose of this analysis is to investigate the degree to which the U. S. Nuclear Regulatory Commission (NRC) has accepted and approved the use of digital control technology for safety-related applications within the nuclear power industry. This analysis reviews cases of existing digitally-based control systems that have been approved by the NRC. These cases can serve as precedence for using similar types of digitally-based control technologies within the Subsurface Repository. While it is anticipated that the Yucca Mountain Project (YMP) will not contain control systems as complex as those required for a nuclear power plant, the review of these existing NRC approved applications will provide the YMP with valuable insight into the NRCs review process and design expectations for safety-related digital control systems. According to the YMP Compliance Program Guidance, portions of various NUREGS, Regulatory Guidelines, and nuclear IEEE standards the nuclear power plant safety related concept would be applied to some of the designs on a case-by-case basis. This analysis will consider key design methods, capabilities, successes, and important limitations or problems of selected control systems that have been approved for use in the Nuclear Power industry. An additional purpose of this analysis is to provide background information in support of further development of design criteria for the YMP. The scope and primary objectives of this analysis are to: (1) Identify and research the extent and precedence of digital control and remotely operated systems approved by the NRC for the nuclear power industry. Help provide a basis for using and relying on digital technologies for nuclear related safety critical applications. (2) Identify the basic control architecture and methods of key digital control

Constructing target product profiles (TPPs) to help vaccines overcome post-approval obstacles

OpenAIRE

Lee, Bruce Y.; Burke, Donald S.

2009-01-01

As history has demonstrated, post-approval obstacles can impede a vaccine’s use and potentially lead to its withdrawal. Addressing these potential obstacles when changes in a vaccine’s technology can still be easily made may improve a vaccine’s chances of success. Augmented vaccine target product profiles (TPPs) can help vaccine scientists better understand and anticipate these obstacles and galvanize conversations among various vaccine stakeholders (e.g., scientists, marketers, business deve...

MARKETING AND INNOVATION IN ENVIRONMENT BANKING FINANCIAL - REQUIREMENTS IN A KNOWLEDGE-BASED SOCIETY AND TECHNOLOGY

Directory of Open Access Journals (Sweden)

MIRCEA VALERIA ARINA

2015-04-01

Full Text Available In the context of knowledge-based economy and society has acquired a connotation marketing role vital for all fields. Evolution of social, cultural, political and economic, information, design and conduct of marketing activities contribute to increasing the efficiency of any institution. Evolution of marketing over time provoked the great researchers who have tried to define the concept of their views, but only surprising aspects of this vast and important field. The definitions are different as shown in the article approach, the essence is the same. In the banking and financial role of marketing is to continually improve the quality of customer services and products offered by formulating appropriate marketing strategies so as to be able to influence The consumer buying behavior. Customer focus, his loyalty and not least an innovative marketing that starts at the client key aspects FEATURES today. The emphasis on innovation and ingenuity in order to: create new banking services and products, ways to attract customers; loyalty of existing ones, defining marketing and communication strategies lead to appropriate strategies to maximize the results of innovative marketing campaigns. Referring to work in the banking environment we can say that innovation is the key to success BANK and are based on: product and service innovations, process innovations, organizational innovations, and not least of marketing innovations.

Utility-Marketer Partnerships. An Effective Strategy for Marketing Green Power?

Energy Technology Data Exchange (ETDEWEB)

Bird, L. A. [National Renewable Energy Lab. (NREL), Golden, CO (United States); Brown, E. S. [National Renewable Energy Lab. (NREL), Golden, CO (United States)

2006-04-01

This paper explores whether partnerships between utilities and independent marketers are an effective strategy for marketing green power. We present case studies of voluntary and mandatory partnerships covering green power program design and implementation in both regulated and restructured electricity markets. We also include perspectives (based on interviews) from utilities, marketers, and regulators involved in developing and implementing these partnerships. From these case studies and interviews, we describe lessons learned about developing effective partnerships, including such issues as respective roles in marketing and administration, product branding, and contract and incentive structures. Based on experience to date, strategic partnerships between utilities and marketers can be an effective approach to marketing green power. Partnerships leverage the sales and resource procurement experience of marketers and the utility’s reputation and access to customers. Further, partnerships can create greater incentives for success because marketers have a vested financial interest in maximizing customer participation and green power sales.

Utility-Marketing Partnerships: An Effective Strategy for Marketing Green Power?

Energy Technology Data Exchange (ETDEWEB)

Bird, L. A.; Brown, E. S.

2006-04-01

This paper explores whether partnerships between utilities and independent marketers are an effective strategy for marketing green power. We present case studies of voluntary and mandatory partnerships covering green power program design and implementation in both regulated and restructured electricity markets. We also include perspectives (based on interviews) from utilities, marketers, and regulators involved in developing and implementing these partnerships. From these case studies and interviews, we describe lessons learned about developing effective partnerships, including such issues as respective roles in marketing and administration, product branding, and contract and incentive structures. Based on experience to date, strategic partnerships between utilities and marketers can be an effective approach to marketing green power. Partnerships leverage the sales and resource procurement experience of marketers and the utility?s reputation and access to customers. Further, partnerships can create greater incentives for success because marketers have a vested financial interest in maximizing customer participation and green power sales.

Identity based marketing: a new balanced marketing paradigm

NARCIS (Netherlands)

Alsem, K.J.; Kostelijk, Erik Jan

2008-01-01

Purpose – The purpose of this paper is to propose a fundamentally new extension of the marketing paradigm. This is theoretically and practically necessary since in the authors' view there is an insufficient balance between customer and brand thinking. Design/methodology/approach – While the

Evaluation on Core Competitiveness of Wholesale Market of Agricultural Products Based on CWAA Operator

Institute of Scientific and Technical Information of China (English)

2011-01-01

According to relevant data,we select five indices,namely management ability,organization and management capability,enterprise culture,development ability and technical equipment ability,to establish the index system of core competitiveness of wholesale market of agricultural products.Based on combination weight arithmetic average(CWAA) operator,we advance an evaluation model of core competitiveness of wholesale market of agricultural products which involves participation of many people.By inviting five exerts,we conduct evaluation in terms of management ability of wholesale market of agricultural products,organization and management capability of leadership,enterprise culture of wholesale market of agricultural products,future development ability of wholesale market of agricultural products,and exiting technical equipment ability of wholesale market of agricultural products.We adopt hundred-mark system to grade and evaluate core competitiveness of wholesale market of agricultural products.The results show that the experts’ evaluation score of core competitiveness of wholesale market of agricultural products is high.The evaluation result is reasonable and authentic and this model is feasible.

75 FR 500 - Self-Regulatory Organizations; New York Stock Exchange LLC; Order Approving a Proposed Rule...

Science.gov (United States)

2010-01-05

.... 61043 (November 20, 2009), 74 FR 62612. On January 22, 2009, the Commission approved the formation of... wholly-owned subsidiary, NYSE Market, Inc., owns less than 9% of the aggregate limited partnership... proposed rule's impact on efficiency, competition, and capital formation. See 15 U.S.C. 78c(f). \\12\\ 15 U.S...

Transforming Markets, Increasing Access : Early Lessons on Base-of-the-Pyramid Market Development in Sanitation

OpenAIRE

Danielle Pedi; Will Davies

2013-01-01

The four billion global consumers at the base of the pyramid (BOP) - those earning less than two dollars a day - are increasingly recognized by the private sector as a major untapped market segment. The sanitation industry is no exception. Across sub-Saharan Africa, more than half of the population lives without access to minimum levels of improved sanitation. Beyond the reach of urban sew...

Fatal adverse drug reactions of anticancer drugs detected by all-case post-marketing surveillance in Japan.

Science.gov (United States)

Mori, Jinichi; Tanimoto, Tetsuya; Miura, Yuji; Kami, Masahiro

2015-06-01

All-case post-marketing surveillance of newly approved anticancer drugs is usually conducted on all patients in Japan. The present study investigates whether all-case post-marketing surveillance identifies fatal adverse drug reactions undetected before market entry. We examined fatal adverse drug reactions identified via all-case post-marketing surveillance by reviewing the disclosed post-marketing surveillance results, and determined the time points in which the fatal adverse drug reactions were initially reported by reviewing drug labels. We additionally scanned emergency alerts on the Japanese regulatory authority website to assess the relationship between all-case post-marketing surveillance and regulatory action. Twenty-five all-case post-marketing surveillances were performed between January 1999 and December 2009. Eight all-case post-marketing surveillances with final results included information on all fatal cases. Of these, the median number of patients was 1287 (range: 106-4998), the median number of fatal adverse drug reactions was 14.5 (range: 4-23). Of the 111 fatal adverse drug reactions detected in the eight post-marketing surveillances, only 28 (25.0%) and 22 (19.6%) were described on the initial global and the initial Japanese drug label, respectively, and 58 (52.3%) fatal adverse drug reactions were first described in the all-case post-marketing surveillance reports. Despite this, the regulatory authority issued only four warning letters, and two of these were prompted by case reports from the all-case post-marketing surveillance. All-case post-marketing surveillance of newly approved anticancer drugs in Japan was useful for the rigorous compilation of non-specific adverse drug reactions, but it rarely detected clinically significant fatal adverse drug reactions. © The Author 2015. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com.

78 FR 26771 - Mesa Wind Power Corporation; Supplemental Notice That Initial Market-Based Rate Filing Includes...

Science.gov (United States)

2013-05-08

... Wind Power Corporation's application for market-based rate authority, with an accompanying rate... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. ER13-1346-000] Mesa Wind Power Corporation; Supplemental Notice That Initial Market-Based Rate Filing Includes Request for...

Asymmetry Effects in Volatility on the Major European Stock Markets: the EGARCH Based Approach

Directory of Open Access Journals (Sweden)

Joanna Olbrys

2017-12-01

Full Text Available The main goal of this paper is to investigate the asymmetric impact of innovations on volatility in the case of the largest European stock markets in the United Kingdom, France and Germany by using the EGARCH based approach. The sample period begins in January 2003 and ends in December 2016, and it includes the 2007 U.S. subprime crisis. The robustness analysis of empirical results is provided with respect to the whole sample and three adjacent subsamples, each of equal size: 1 the pre-crisis, 2 the Global Financial Crisis (GFC and 3 the post-crisis periods. The GFC periods are formally detected by using a statistical method of dividing market states into bullish and bearish markets. Moreover, the common trading window procedure is employed to avoid the nonsynchronous trading problem in the group of investigated markets and to get the overlapping information set. We estimate univariate EGARCH models based on daily percentage logarithmic returns of major stock market indexes: FTSE100 (London, CAC40 (Paris, and DAX (Frankfurt. Pronounced negative asymmetry effects in volatility are presented in the case of all markets and are rather robust to the choice of the period. Our findings are consistent with the literature and suggest that the major European stock markets are more sensitive to ’bad’ than ‘good’ news.

38 CFR 17.65 - Approvals and provisional approvals of community residential care facilities.

Science.gov (United States)

2010-07-01

... approvals of community residential care facilities. 17.65 Section 17.65 Pensions, Bonuses, and Veterans' Relief DEPARTMENT OF VETERANS AFFAIRS MEDICAL Community Residential Care § 17.65 Approvals and provisional approvals of community residential care facilities. (a) An approval of a facility meeting all of...

Firm-Specific Marketing Capital and Job Satisfaction of Marketers: Evidence from Vietnam

Science.gov (United States)

Nguyen, Tho D.; Nguyen, Trang T. M.

2011-01-01

Purpose: Based on the resource-based view of the firm, this study aims to examine antecedents and outcomes of firm-specific marketing capital pool invested by marketers in a transition market, Vietnam. Design/methodology/approach: A sample of 528 marketers in Ho Chi Minh City was surveyed to test the theoretical model. Structural equation…

An empirical study of marketing communications effectiveness in Slovenian market

OpenAIRE

Jerman, Damjana; Završnik, Bruno

2017-01-01

This paper deals with the value or more specifically, the contribution of marketing communications strategy to effectiveness of marketing communications and hypothesizes that marketing communications strategy correlate with the effectiveness of marketing communications. The paper consists of two parts: the theoretical framework for the role of marketing communications strategy for the effectiveness of the marketing communications and the empirical analysis, based on the primary data collected...

Consequences of Market-Based Measures CO2-emission Reduction Maritime Transport for the Netherlands; Gevolgen Market Based Measures CO2-emissiereductie zeevaart voor Nederland

Energy Technology Data Exchange (ETDEWEB)

Wortelboer-van Donselaar, P.; Kansen, M.; Moorman, S. [Kennisinstituut voor Mobiliteitsbeleid KiM, Den Haag (Netherlands); Faber, J.; Koopman, M.; Smit, M. [CE Delft, Delft (Netherlands)

2013-11-15

The introduction of Market Based Measures (MBMs) to reduce the CO2 emissions of international sea shipping will have relatively limited economic effects for the Netherlands. Moreover, these effects are largely in line with those in other countries. For the Netherlands, however, the manner in which MBMS are organised and enforced is likely to be particularly important, given the importance of ports to the Dutch economy, the country's relatively large bunker sector, and the fact that Dutch shipowners operate relatively small vessels and on a relatively small scale. MBMs include pricing measures in the form of tax or trade systems, as well as other market-related proposals. In this research study, the consequences are analysed of four international MBM proposals for the Netherlands [Dutch] Om de CO2-uitstoot van de internationale zeevaartsector terug te dringen worden momenteel zogeheten Market Based Measures (MBMs), zoals bijvoorbeeld het veilen van emissierechten of het invoeren van een heffing, overwogen. De invoering van de MBMs zal voor Nederland relatief beperkte economische effecten hebben. Deze effecten wijken bovendien niet bijzonder af van die voor andere landen. De wijze waarop de MBMs worden georganiseerd en gehandhaafd, is voor Nederland mogelijk wel van onderscheidend belang. Dit gezien het belang van de havens voor de Nederlandse economie, de relatief grote bunkersector, en de relatief kleine schepen en kleinschaligheid van de Nederlandse reders.

ETHICS AND MARKETING IN THE KNOWLEDGE BASED SOCIETY

Directory of Open Access Journals (Sweden)

Liliana HÎNCU

2015-07-01

Full Text Available This paper aims to highlight the relationship between marketing and ethics. Today we face great challenges given the so-called knowledge society, as through the internet and social networks we can learn anything about anyone, including large corporations and about. The work that we realized is composed of two parts, namely: the ethics part and marketing, and later to stress that ethical marketing concept means and how it can be achieved in our country. Marketing appeared a long time ago, at first in the USA during the first part of the twentieth century. The modern concept of the term marketing refers to the main purpose of the economic activity, which is consumer satisfaction. During the last five decades, along with the development of tourism, marketing interferes with this area and gradually expands to other areas as well. Many authors try to define tourism marketing in certain ways, but eventually tourism marketing is presented as a process of identifying and ensuring the formula by which both consumer satisfaction and the achievement of the entrepreneurial goals become possible. During their daily activity, marketers face various moral issues, but most often the activities they undertake are not clear in terms of ethics.

77 FR 62510 - Niagara Wind Power, LLC; Supplemental Notice That Initial Market-Based Rate Filing Includes...

Science.gov (United States)

2012-10-15

... Wind Power, LLC's application for market-based rate authority, with an accompanying rate schedule... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. ER13-17-000] Niagara Wind Power, LLC; Supplemental Notice That Initial Market- Based Rate Filing Includes Request for Blanket...

75 FR 42745 - Hardscrabble Wind Power LLC; Supplemental Notice That Initial Market-Based Rate Filing Includes...

Science.gov (United States)

2010-07-22

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. ER10-1725-000] Hardscrabble Wind Power LLC; Supplemental Notice That Initial Market-Based Rate Filing Includes Request for Blanket... of Hardscrabble Wind Power LLC's application for market-based rate authority, with an accompanying...

78 FR 62615 - Healthy Planet Partners Energy Company, LLC; Supplemental Notice that Initial Market-Based Rate...

Science.gov (United States)

2013-10-22

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. ER14-96-000] Healthy Planet Partners Energy Company, LLC; Supplemental Notice that Initial Market-Based Rate Filing Includes Request... of Healthy Planet Partners Energy Company, LLC's application for market- based rate authority, with...

76 FR 77815 - Ethical Electric Benefit Co.; Supplemental Notice That Initial Market-Based Rate Filing Includes...

Science.gov (United States)

2011-12-14

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. ER12-543-000] Ethical Electric Benefit Co.; Supplemental Notice That Initial Market-Based Rate Filing Includes Request for... Ethical Electric Benefit Co.'s application for market-based rate authority, with an accompanying rate...

78 FR 34371 - Centinela Solar Energy, LLC; Supplemental Notice That Initial Market-Based Rate Filing Includes...

Science.gov (United States)

2013-06-07

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. ER13-1561-000] Centinela Solar Energy, LLC; Supplemental Notice That Initial Market-Based Rate Filing Includes Request for... Centinela Solar Energy, LLC's application for market-based rate authority, with an accompanying rate...

75 FR 80486 - Sustainable Star, LLC; Supplemental Notice That Initial Market-Based Rate Filing Includes Request...

Science.gov (United States)

2010-12-22

... proceeding of Sustainable Star, LLC's application for market-based rate authority, with an accompanying rate... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. ER11-2354-000] Sustainable Star, LLC; Supplemental Notice That Initial Market- Based Rate Filing Includes Request for Blanket...

77 FR 57082 - Prairie Rose Wind, LLC; Supplemental Notice That Initial Market-Based Rate Filing Includes...

Science.gov (United States)

2012-09-17

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. ER12-2542-000] Prairie Rose Wind, LLC; Supplemental Notice That Initial Market- Based Rate Filing Includes Request for Blanket... Rose Wind, LLC's application for market-based rate authority, with an accompanying rate schedule...

77 FR 64980 - Collegiate Clean Energy, LLC; Supplemental Notice That Initial Market-Based Rate Filing Includes...

Science.gov (United States)

2012-10-24

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. ER13-33-000] Collegiate Clean Energy, LLC; Supplemental Notice That Initial Market-Based Rate Filing Includes Request for... Collegiate Clean Energy, LLC's application for market-based rate authority, with an accompanying rate tariff...

75 FR 16453 - Nasdaq OMX Commodities Clearing-Finance, LLC; Supplemental Notice That Initial Market-Based Rate...

Science.gov (United States)

2010-04-01

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. ER10-914-000] Nasdaq OMX Commodities Clearing--Finance, LLC; Supplemental Notice That Initial Market-Based Rate Filing Includes Request...-referenced proceeding of Nasdaq OMX Commodities Clearing--Finance, LLC's application for market- based rate...

75 FR 71426 - North Community Turbines, LLC; Supplemental Notice That Initial Market-Based Rate Filing Includes...

Science.gov (United States)

2010-11-23

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. ER11-2107-000] North Community Turbines, LLC; Supplemental Notice That Initial Market-Based Rate Filing Includes Request for... proceeding, of North Community Turbines, LLC's application for market-based rate authority, with an...

77 FR 47625 - Beebe Renewable Energy, LLC; Supplemental Notice That Initial Market-Based Rate Filing Includes...

Science.gov (United States)

2012-08-09

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. ER12-2311-000] Beebe Renewable Energy, LLC; Supplemental Notice That Initial Market-Based Rate Filing Includes Request for... Beebe Renewable Energy, LLC's application for market-based rate authority, with an accompanying rate...

78 FR 50410 - Black Bear Development Holdings, LLC; Supplemental Notice that Initial Market-Based Rate Filing...