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Sample records for maltais-landry roxane maranger

  1. The orbits of satellites of (22) Kalliope and (317) Roxane

    Science.gov (United States)

    Drummond, Jack D.; Reynolds, Odell; Buckman, Miles; Eickhoff, Mark

    2017-10-01

    Between October 2016 and February 2017 we imaged asteroid (22) Kalliope (10.3RC) a=243+/-6 km; P=11.5265+/-0.0204 d; T0=2457725.137+/-0.050; Pole[RA;Dec]=[ 96.2;-68.3]; e=0Roxane S/1 (PC) a=245+/-6 km; P=11.5858+/-0.0203 d; T0=2457721.631+/-0.051; Pole[RA;Dec]=[275.7;+68.8]; e= 0Roxane S/1 (RE) a=251+/-8 km; P=11.4927+/-0.0215 d; T0=2457717.730+/-0.126; Pole[RA;Dec]=[ 95.3; -67.8]; e=0.178+/-0.061ω=124+/-4Roxane S/1 (PE) a=249+/-7 km; P=11.5594+/-0.0190 d; T0=2457717.603+/-0.162; Pole[RADec]=[276.6+69.2]e=0.133+/-0.038ω= 230+/-5Roxane’s moon’s orbital pole is less than 4 degrees from the Ecliptic pole or Roxane’s orbital pole, but more than 22 degrees from Roxane’s rotational pole. Perhaps this indicates that the moon was captured from the Ecliptic plane rather than spun into Roxanne’s equatorial plane.The Starfire Optical Range’s 3.5 m telescope is the smallest ground based telescope used to derive orbits of asteroid satellites. Kalliope and Roxane follow our study of (87) Sylvia and its Romulus (Drummond, Reynolds, and Buckman (2016), Icarus 276, 107-115).

  2. Marang: Journal of Language and Literature

    African Journals Online (AJOL)

    Marang: Journal of Language and Literature is an annual peer-reviewed journal. ... on a wide range of topics in literature, language, linguistics and theatre studies. ... the labyrinthine meanderings of periodic and cumulative English sentences ...

  3. The Influence of Tidal Activities on Hydrologic Variables of Marang River, Terengganu, Malaysia

    International Nuclear Information System (INIS)

    Mohd Ekhwan Toriman; Mohd Ekhwan Toriman; Muhammad Barzani Gasim; Nur Hidayah Ariffin; Haniff Muhamad; Norsyuhada Hairoma

    2015-01-01

    A study was conducted at Marang River, Terengganu on determination of hydrological variation of Marang River at seven sampling stations. Sampling stations were selected along Marang River started from downstream to upstream. Each station was located 2 km apart from each other. Sampling was done twice; the first sampling was in 13 November 2012 (rainy season) and was repeated for second sampling on 24 February 2013 (dry season). Hydrological measurements of river such as velocity, river width and river depth were measured by using specific equipment. River velocity was measured by using flow meter (model FP101), river width was measured by using a range finder (model Bushnell 20-0001) and river depth was measured by using depth meter. Primary data of hydrological measurements of Marang River were measured and analyzed for each sampling station. Overall, station 1 shows the highest readings for most hydrological variables at both water tides during the first and second samplings. Station 1 that was located at the Marang River estuary identified by higher hydrological variables due to seawater movement during high tide as compared to stations 7 which located at the upstream. During dry season hydrological variables were slightly decrease since low freshwater flow from the upstream due to less rainfall intensity. (author)

  4. The Influence of Tidal Activities on Water Quality of Marang River, Terengganu, Malaysia

    International Nuclear Information System (INIS)

    Muhammad Barzani Gasim; Nur Hidayah Ariffin; Haniff Muhamad; Norsyuhada Hairoma

    2015-01-01

    A study was conducted at seven sampling stations to determine water quality condition of Marang River, Terengganu. Each station was 2 km apart from each other, the first sampling was in 13 November 2012 and was repeated in 24 November 2013. The aim of the study is to determine water quality in spatial and temporal variation on different tides based on selected fourteen physicochemical parameters with regard to National Water Quality Standard. Six in-situ parameters such as pH, temperature, salinity, conductivity, DO and TDS were measured by using YSI 556 Multi parameters. Six ex-situ parameters such as sulphate, sodium, nitrate, phosphate, magnesium and turbidity also were measured. Sulphate, nitrate, phosphate and turbidity were analysed according to the standard method of analysis by Portable Data logging Spectrophotometer HACH DR/2010. Sodium and magnesium were analysed using Atomic Absorption Spectrophotometer. One way ANOVA shows that there are no significant changes between first sampling and second sampling, the data were average to give impression of water quality of Marang River in spatial and temporal perspective. Overall, water quality of Marang River was classified as class I to III according to NWQS classification, therefore Marang River needs proper water treatment for tolerant fish species and other aquatic water continuance. (author)

  5. Marang: Journal of Language and Literature - Vol 18 (2008)

    African Journals Online (AJOL)

    An Analysis of Two Setswana Colour Terms: Ntsho and Tshweu · EMAIL FULL TEXT EMAIL FULL TEXT DOWNLOAD FULL TEXT DOWNLOAD FULL TEXT. TJ Otlogetswe, M M Bagwasi, 1-14. http://dx.doi.org/10.4314/marang.v18i1.39322 ...

  6. Drums for pump organs | Setiloane | Marang: Journal of Language ...

    African Journals Online (AJOL)

    Marang: Journal of Language and Literature. Journal Home · ABOUT THIS JOURNAL · Advanced Search · Current Issue · Archives · Journal Home > Vol 2, No 1 (1978) >. Log in or Register to get access to full text downloads. Username, Password, Remember me, or Register. DOWNLOAD FULL TEXT Open Access ...

  7. "Pregnancy and Landry Gullian Barre syndrome".

    Science.gov (United States)

    Iloabachie, G C

    1994-01-01

    Landry Gullian Barre Syndrome is rare in pregnancy. The case described occurred in a 30 year old woman at a gestational age of 33 weeks. This is probably the 30th case described in the Literature. Unlike in some previous reports remarkable improvement occurred with caesarean section.

  8. Boy Masaka is no more | Mchunu | Marang: Journal of Language ...

    African Journals Online (AJOL)

    Marang: Journal of Language and Literature. Journal Home · ABOUT THIS JOURNAL · Advanced Search · Current Issue · Archives · Journal Home > Vol 2, No 1 (1978) >. Log in or Register to get access to full text downloads. Username, Password, Remember me, or Register. DOWNLOAD FULL TEXT Open Access ...

  9. Pioneering the concepts of stereognosis and polyradiculoneuritis: Octave Landry (1826-1865).

    Science.gov (United States)

    Walusinski, Olivier

    2013-01-01

    Octave Landry was one of a long list of fine 19th century clinicians who died very young and whose discoveries in physiology and descriptions of new clinical pictures helped found current-day neurology. In 1852, Landry proposed a new take on the physiology of sensation which laid the ground for the concepts of proprioception and stereognosis. He also described the clinical picture of a rapidly progressing ascending paralysis, which in 1859 prefigured Guillain-Barré syndrome. In discussing his very active life, we will mention the hydrotherapies in fashion at the time and the pleasures of Parisian society. Landry's career was also marked by terrible cholera epidemics, one of which killed him at age 39, in the prime of his working life as a devoted physician. Copyright © 2013 S. Karger AG, Basel.

  10. A new species of Eccopsis Zeller (Lepidoptera, Tortricidae from the coastal valleys of northern Chile, with the first continental record of E. galapagana Razowski & Landry

    Directory of Open Access Journals (Sweden)

    Héctor A. Vargas

    2011-06-01

    Full Text Available A new species of Eccopsis Zeller (Lepidoptera, Tortricidae from the coastal valleys of northern Chile, with the first continental record of E. galapagana Razowski & Landry. Eccopsis Zeller, 1852 is reported for the first time from Chile. Eccopsis razowskii Vargas, n. sp. is described and illustrated based on specimens reared from larvae collected on native Acacia macracantha Willd. (Fabaceae in the coastal valleys of the northern Chilean desert. Eccopsis galapagana Razowski & Landry, 2008, previously known only from the Galapagos Islands, Ecuador, is recorded for the first time from continental South America. Larvae of the latter were collected in northern Chile feeding on Prosopis alba Griseb (Fabaceae.

  11. Description of the early stages of Eccopsis galapagana Razowski & Landry (Lepidoptera: Tortricidae), a defoliator of Prosopis juliflora (Sw.) DC (Fabaceae) in Colombia

    Science.gov (United States)

    The biology and early stages of Eccopsis galapagana Razowski & Landry are described and illustrated for the first time; details of the adults also are provided. Under outbreak conditions, the species has become a serious pest of algarrobo tree (Prosopis juliflora (Sw.) DC.; Fabaceae) in Colombia. Al...

  12. Genetic relatedness of low solitary nests of Apis dorsata from Marang, Terengganu, Malaysia.

    Directory of Open Access Journals (Sweden)

    Najmeh Sahebzadeh

    Full Text Available Knowledge on the population of genetic structure and ecological behaviour of Apis dorsata from Peninsular Malaysia is needed for effective management and conservation of this species since unsustainable whole solitary low nest cutting for product harvesting is the current common practice here. The analysis of 15 single locus DNA microsatellite markers on samples from 20 solitary nests of A. dorsata showed that while these markers were polymorphic, high intracolonial relatedness existed. Furthermore, in general, slightly negative values of intercolony relatedness (R among the nests of A. dorsata were found. However, positive values of mean intercolony relatedness were observed between 54 pairs of nests out of 190 possible combinations. The R values among nest pairs 3-4 and 3-5 was higher than 0.50 showing that their queens were half siblings, whereas nest pair 19-20 showed relatedness of 0.95 indicating that the same queen was sampled. The results that we obtained could not conclusively support the hypothesis of this study that the honey hunters in Marang district of Malaysia repeatedly harvest the same nest located at a different site and at a different time during the same honey harvesting season. However, our finding of an appreciable level of intercolonial relatedness between several pairs of nests in this pioneer study indicated that a comprehensive study with a larger sample size of solitary nests found throughout the region would be necessary to provide concrete proof for this novel idea.

  13. Normand LANDRY et Anne-Sophie LETELLIER (dir.) (2016), L’éducation aux médias à l’ère numérique. Entre fondations et renouvellement

    OpenAIRE

    Kouawo, Candide Achille Ayayi

    2018-01-01

    L’ouvrage collectif dirigé par Normand Landry et Anne-Sophie Letellier porte sur la thématique de l’éducation aux médias, et ce, dans une société où les technologies numériques sont omniprésentes. Dès l’introduction, les auteurs nous immergent dans une société hautement médiatisée où, à travers les réseaux numériques, nous avons accès à de multiples services. Il est donc impératif de poser un regard critique sur ces nouveaux médias, sur l’information, sur les pratiques et sur les attitudes qu...

  14. Polymorphisms in VEGF-A are associated with COPD risk in the ...

    Indian Academy of Sciences (India)

    2016-03-04

    Mar 4, 2016 ... age and smoking status are listed in table 1 and the clas- sification of COPD ..... Gagnon P., Guenette J. A., Langer D., Laviolette L., Mainguy V.,. Maltais F. et al. ... nucleotide polymorphisms on non-small cell lung cancer tumor.

  15. D. mordor and D. galapagensis, new species, in the Spilomelinae of the Galapagos Island, Ecuador

    Science.gov (United States)

    The largest subfamily of Pyraloidea of the Galápagos fauna is reviewed. Forty-four species are recorded and illustrated, including the male and female genitalia. Eleven species are described as new: Agathodes galapagensis Landry sp. n., Desmia mordor Landry & Solis sp. n., Diaphania galapagensis Lan...

  16. 77 FR 22475 - Standard Instrument Approach Procedures, and Takeoff Minimums and Obstacle Departure Procedures...

    Science.gov (United States)

    2012-04-16

    ..., Orig, CANCELLED Fort Huachuca Sierra Vista, AZ, Sierra Vista Muni-Libby AAF, RADAR-1, Orig Fort Huachuca Sierra Vista, AZ, Sierra Vista Muni-Libby AAF, RADAR-2, Orig Lake Havasu City, AZ, Lake Havasu... Opelousas, LA, St Landry Parish-Ahart Field, NDB RWY 18, Amdt 3 Opelousas, LA, St Landry Parish-Ahart Field...

  17. Ways of Knowing Ways of Understanding and Ways of Coping: HIV ...

    African Journals Online (AJOL)

    Marang: Journal of Language and Literature. Journal Home · ABOUT THIS JOURNAL · Advanced Search · Current Issue · Archives · Journal Home > Vol 20 (2010) >. Log in or Register to get access to full text downloads.

  18. [Demographic transition or revolution? The weaknesses and implications of the demographic transition theory. Part 1: the origins].

    Science.gov (United States)

    Bourcier De Carbon, P

    1998-01-01

    The work of Adolphe Landry is reviewed in relation to development of demographic transition theory. Landry was appointed administrator in 1912 of the National Alliance Against Depopulation and remained active in it his whole life. He also helped create family allowance programs in France. As early as 1909, Landry described three different population regimes. In the "primitive" regime, which characterized all nonhuman life and human life during most of history, the population was adjusted to available subsistence by mortality. In the "intermediate" phase, restrictions on marriage and control of reproduction outside marriage maintained the population at a level below the maximum supportable. In the "contemporary" regime, the universal practice of contraception and abortion could lead to very low levels of fertility. The spread of contraception and low fertility appeared to Landry a true demographic revolution. He attributed the acceptance of contraception to a change in the common aspirations of human beings regarding their conditions, a desire for improved material well-being and social advancement, and an increased spirit of rationality and even calculation in their behavior. Landry believed that the contemporary regime, unlike the preceding two, had no mechanism implying equilibrium. The demographic revolution freed fertility from social determinants and linked it more closely to individual interests. Landry expected the contemporary regime to spread throughout the entire world, with many areas still in the primitive phase passing directly to the contemporary. He was concerned with the effects of demographic aging, and he deplored birth control propaganda that claimed it as a cure for unemployment and for overpopulation in the poor Asian countries. The birth control movements in England and the US were successful in bringing the two countries into the contemporary regime. A number of organizations such as the Population Association of America and the Office of

  19. Members of the Forum Engelberg visit CERN

    CERN Multimedia

    Patrice Loïez

    2002-01-01

    The Forum Engelberg is an annual interdisciplinary conference held in Engelberg, Switzerland intended to act as an international platform for debate and exchange of views on key issues affecting scientific research, technology, economics and philosophy. Its President is Hubert Curien - former French Minister of Research and Space Research, and President of the CERN Council from 1994 to 1996.Seated here at a presentation by Peter Jenni, spokesperson for the ATLAS collaboration, during the visit of Forum members and Geneva public figures are Bernard Ecoffey, Founder of the Forum Engelberg (left), and Jean-Claude Landry, Department of the Interior, Agriculture and Environment, state of Geneva. Photo 01: (left to right) Bernard Ecoffey, Jean-Claude Landry and Peter Jenni. Photos 02, 03: (left to right) Jean-Claude Landry, Bernard Ecoffey and Peter Jenni.

  20. Patterns of consumption and materialism among Zimbabwean ...

    African Journals Online (AJOL)

    We contend that despite their common theological heritage in the protestant ethics and its bible-centred dogma, the United Family International Church and the Johanne Marange Church have in the postcolonial context, each forged distinct theological and ecclesiastical understandings of their relation to consumption and ...

  1. Implementation of Educational Innovation: The Case of Speaking ...

    African Journals Online (AJOL)

    Implementation of Educational Innovation: The Case of Speaking Assessment in the BGCSE English Examination. ... Marang: Journal of Language and Literature ... The findings have indicated that there are two main contending categories of education officers who have a stake in what is taught and assessed in BGCSE ...

  2. ESP and ELT: an overview of the common ground | Mathangwane ...

    African Journals Online (AJOL)

    Marang: Journal of Language and Literature. Journal Home · ABOUT THIS JOURNAL · Advanced Search · Current Issue · Archives · Journal Home > Vol 8, No 1 (1990) >. Log in or Register to get access to full text downloads. Username, Password, Remember me, or Register. DOWNLOAD FULL TEXT Open Access ...

  3. Potential of sea level rise impact on South China Sea: a preliminary ...

    African Journals Online (AJOL)

    The effect of the sea level rise was involved the existence of sea water intrusion and coastal erosion phenomenon in the coastal of Terengganu. This study aim to determine fluctuation of high and low tides of the South China Sea in their relation to water quality value of Marang and Paka Rivers as well as from wells ...

  4. Setswana Oral Narrative Performance | Nhlekisana | Marang ...

    African Journals Online (AJOL)

    PROMOTING ACCESS TO AFRICAN RESEARCH. AFRICAN ... This paper argues that the Setswana storytelling session is a highly participatory event. The paper ... Keywords: performance, storytelling, narrator, audience, narrative, Setswana ...

  5. 78 FR 14149 - Louisiana Disaster #LA-00050

    Science.gov (United States)

    2013-03-04

    ..., Franklin, Jefferson, Livingston, Madison, Saint Landry, Vermilion. The Interest Rates are: Percent For... economic injury is 13503B. (Catalog of Federal Domestic Assistance Numbers 59002 and 59008) James E. Rivera...

  6. Accessing African History Through Literature | Ngongkum | Marang ...

    African Journals Online (AJOL)

    Drawing from the premise that African literature is largely functional, this paper aims at showing its validity in offering its readers fundamental aspects of African history. The paper argues that the very groundedness of cultural artefacts, literature inclusive, in history makes this possible. The paper will use sample texts from ...

  7. Littérature orale arabo-berbère,Ville juifCNRS/ E.R.S. 1723n° 27, 1999

    OpenAIRE

    Daoud, Mohamed

    2013-01-01

    La revue est d’abord l’expression du groupe de recherche "Littérature orale, dialectologie, ethnologie du domaine arabo-berbère, C.N.R.S.[U.P.R.414]. Le conte revisité par le poète. Intertextualité et création (Paulette Galand-Pemet) ; Une “randonnée” touarègue, ou l’apprentissage des tifinagh (Jeanine Drouin) ; Une vengeance intra-familiale entre cochers maltais de Tunis. Le récit d’Antoinette Schembri 1895-1988 (Carmel Sammut) ; Pour un répertoire des motifs dans les contes merveilleux magh...

  8. Optimization of yeast (Saccharomyces cerevisiae) RNA isolation ...

    African Journals Online (AJOL)

    Yomi

    2012-01-16

    Jan 16, 2012 ... isolation method for real-time quantitative PCR and microarray ... disease genes to experimental evolution and systems biology (Landry et al., .... scanning, and preliminary analyses with GeneChip Operating. Software 1.4 ...

  9. Wine and cheese: two products or one association? A new method for assessing wine-cheese pairing

    OpenAIRE

    Dufau, Lucie; Loiseau, Anne-Laure; Visalli, Michel; Schlich, Pascal

    2018-01-01

    The aim of this study was to identify which attributes impacted the dynamic liking of cheese and wine individually, as well as when consumed together. Three wines (one white, Pouilly Loché; and two red, Maranges and Beaujolais) and three cheeses (Comté, Époisses, Chaource) were individually evaluated by a group of 60 consumers using mono-intake Temporal Dominance of Sensations (TDS) with simultaneous hedonic ratings. The same data acquisition screen was used for all products showing a unique ...

  10. The pen behind the sword: power, literacy and the Roman army

    Directory of Open Access Journals (Sweden)

    John Wilkes

    2001-10-01

    Full Text Available The creation and cohesion of the Roman empire owed much to the spread of literacy through the provinces and the use of texts as an instrument of government. An important manifestation of this is the role of the written word in the Roman army, exemplified by the diplomas that granted Roman citizenship and other privileges to auxiliary soldiers on completion of their military service. Margaret Roxan, one of the Institute's honorary research fellows, has studied these diplomas for many years, and her achievement was honoured at an international conference in London in May 2002.

  11. Microwave synthesis and sintering characteristics of CaCu3 Ti4

    Indian Academy of Sciences (India)

    WINTEC

    Dielectric Materials Division, Central Power Research Institute, Bangalore 560 080, India. ††. Ceramic ..... Landry C C, Lockwood J and Barron A R 1995 Chem. Mater. 7. 699 ... Thakur O P, Chandra Prakash and Agrawal D K 2002 Mater. Lett.

  12. Planning for quality? Assessing the role of quality of place in current Dutch planning practice

    NARCIS (Netherlands)

    Kloosterman, R.C.; Trip, J.J.

    2011-01-01

    In recent years, an attractive urban environment has increasingly been recognized as a factor of local competitiveness in a globalizing world. Notably, Richard Florida and Charles Landry have stressed the importance of the concept of quality of place. The implications of their often criticized, but

  13. characterization qualitative and potentialities of utilization of ...

    African Journals Online (AJOL)

    Y. M’Sadak et A. Ben M’Barek

    1 sept. 2016 ... e is obtained from the digester and the other two from the decanter (d. ) ...... Landry Ch., Lavallée S., Paré M. et Tremblay F. Recherche et ... Gauthier F., Gagnon S. et Dansereau B. Canadian Journal of Plant Science, 1998, vol.

  14. Editorial

    African Journals Online (AJOL)

    Raoul

    2009-09-04

    Sep 4, 2009 ... Provider Initiated Testing and Counseling (PITC) for HIV in resource-limited clinical settings: important questions unanswered. Joseph Becker 1&, Landry Tsague2, Ruben Sahabo2, Peter Twyman2. 1Stanford University School of Medicine, Department of Medicine, Division of Emergency Medicine, ...

  15. Creative city development in the Lisbon strategy : Evidence from Dutch ERDF allocation

    NARCIS (Netherlands)

    Trip, J.J.

    2009-01-01

    Creativity is considered a main factor of urban competitiveness nowadays. However, while local policies increasingly reflect the ideas of Richard Florida, Charles Landry and others, the influence of the creative city concept on higher level policies is not clear. The paper takes this issue to the

  16. 40 CFR 81.319 - Louisiana.

    Science.gov (United States)

    2010-07-01

    ... Grant Parish La Salle Parish Madison Parish Morehouse Parish Ouachita Parish Richland Parish Tensas... Parish St. James Parish St. John the Baptist Parish St. Landry Parish St. Martin Parish St. Mary Parish... Attainment Pointe Coupee Area: Pointe Coupee Parish Attainment St. James Parish Area: St. James Parish...

  17. Antecedent infections and anti-ganglioside antibodies in Guillain-Barré syndrome : their role in pathogenesis and heterogeneity

    NARCIS (Netherlands)

    B.C. Jacobs (Bart)

    1997-01-01

    textabstractThe Guillain-Barre syndrome (GBS) is the most common form of acute neuromuscular paralysis in developed countries, but the pathogenesis is still largely unknown. The major clinical features of the syndrome were first united by J-B.O. Landry in 1859 (1). The syndrome was named after G.

  18. Engineering Bacterial Thiosulfate and Tetrathionate Sensors for Detecting Gut Inflammation

    Science.gov (United States)

    2017-04-03

    sulfate mouse experiments Six- to eight-week-old male C57BL/6 mice were procured from the Center for Comparative Medicine (CCM) Production Colony at the...online. Acknowledgements We thank Sebastian Winter for the kind gift of E. coli Nissle 1917, Brian Landry for help with developing the flow cytometry

  19. Using the Linguistic Landscape to Bridge Languages

    Science.gov (United States)

    Mari, Vanessa

    2018-01-01

    In this article Vanessa Mari describes how she uses the linguistic landscape to bridge two or more languages with students learning English. The linguistic landscape is defined by Landry and Bourhis (1997, 25) as "the language of public road signs, advertising billboards, street names, place names, commercial shop signs, and public signs on…

  20. Marang: Journal of Language and Literature - Vol 20 (2010)

    African Journals Online (AJOL)

    Memory Vocabulary Learning Strategies and Long-Term Retention · EMAIL FULL TEXT EMAIL FULL TEXT DOWNLOAD FULL ... Ways of Knowing Ways of Understanding and Ways of Coping: HIV/AIDS, Poverty and Governance in Zimbabwean Popular Music · EMAIL FULL TEXT EMAIL FULL TEXT DOWNLOAD FULL ...

  1. Students' Rights: A Guide to the Right of Children, Youth and Future Teachers.

    Science.gov (United States)

    Haberman, Martin

    After a preface in which Judge Robert Landry cites the importance of the Galt Decision, the paper summarizes the rights of students in elementary and secondary schools. This is presented through case histories. The decisions are grouped into the categories of freedom of expression, search and seizure, dress and grooming, invasion of privacy, and…

  2. Three Forms of the Knowledge Economy: Learning, Creativity and Openness

    Science.gov (United States)

    Peters, Michael A.

    2010-01-01

    This paper outlines and reviews three forms and associated discourses of the "knowledge economy": the "learning economy", based on the work of Bengt-Ake Lundvall; the "creative economy" based on the work of Charles Landry, John Howkins and Richard Florida; and the "open knowledge economy" based on the work of Yochai Benkler and others. Arguably,…

  3. Ritual in Unity Dow's Far And Beyon | Kgafela-Mokoka | Marang ...

    African Journals Online (AJOL)

    This reinforces the article's argument that the violation of sexual mores leads to HIV and AIDS, and to death. The article also examines Dow's prejudice against rituals and the idea that adherence to cultural and religious sexual mores, and not ritual performance, is the solution to the problem of early deaths in the novel.

  4. Soren Kierkegaard (1813-55): a bicentennial pathographical review.

    Science.gov (United States)

    Schioldann, Johan; Søgaard, Ib

    2013-12-01

    Researchers in the fields of psychology, psychiatry, medicine and theology have made exhaustive efforts to shed light on the elusive biography/pathography of the great Danish philosopher Søren Kierkegaard (1813-55). This 'bicentennial' article reviews his main pathographical diagnoses of, respectively, possible manic-depressive [bipolar] disease, epilepsy, complex partial seizure disorder, Landry-Guillain-Barré's acute ascending paralysis, acute intermittent porphyria with possible psychiatric manifestations, and syphilidophobia.

  5. Diferenciales del desarrollo humano según fase transicional demográfica en las regiones administrativas del Perú 2005 - 2007

    OpenAIRE

    Neciosup Obando, Jorge Eduardo

    2014-01-01

    This research aims to explain how the administrative regions in Peru are classified according to the components that determine the Human Development Index (HDI); also determine how regions are classified according to the transitional phase they are going through. The scientific problem solving can be explained as the differential of Human Development in the administrative regions in Peru, for their transitional phases. Have been constructed indicators as conceptual aspects of Landry and Notes...

  6. Effect of kinesitherapy on physical activity in patient with Guillain-Barré syndrome

    OpenAIRE

    Dimitrova, Antoaneta; Grigorova-Petrova, Kristin; Lubenova, Daniela; Vasileva, Dance; Nikolova, Milena

    2015-01-01

    Introduction: Guillain-Barré syndrome is an autoimmune disease characterized by sudden onset and progressive impairment of peripheral nerves. It is a rare disorder in which weakness and tingling in the extremities are usually the first symptoms. Aim: To study the influence of the applied kinesitherapy in a patient with Guillain-Barré syndrome with severe and protracted course of the disease by deterioration with Landry ascending paralysis and assisted breathing. Material and Methods: T...

  7. Two Concepts Of Place Competition And Specificity Of Targeting In Place Marketing

    OpenAIRE

    Kirill Rozhkov

    2013-01-01

    This paper demonstrates opportunities for the development of the place marketing theory given by pure model of local expenditures (Tiebout 1956) and concepts of the creative class (Florida 2004) and creative city (Bianchini and Landry 1995). Rethinking them in marketing terms, we then analyze their limitations and show why their re-examining can support competition analysis, targeting, and marketing policy of places. In the discussion section, main directions of theoretical research in place ...

  8. Apparent grazing losses of Labyrinthulomycetes protists in oceanic and coastal waters: An experimental elucidation

    Digital Repository Service at National Institute of Oceanography (India)

    Damare, V.S.; Raghukumar, S.

    et al. 1999; Calbet and Landry 2004). For instance, certain suspension-feeding zooplankton prefer protists in their diet (Stoecker and Capuzzo 1990). The no net grazing on Labyrinthulomycetes during other times might have been the result...-Ngando T, Desvilettes C, Bourdier G (2011) Food quality of anemophilous plant pollen for zooplankton. Limnol Oceanogr 56: 939-946. Munn C (2011) Marine Microbiology Ecology and Applications. 2nd Ed. Garland Science, Taylor & Francis Group, USA. Murrell...

  9. Using the Frailty Assessment for Care Planning Tool (FACT) to screen elderly chronic kidney disease patients for frailty: the nurse experience

    OpenAIRE

    Moffatt H; Moorhouse P; Mallery L; Landry D; Tennankore K

    2018-01-01

    Heather Moffatt,1 Paige Moorhouse,1,2 Laurie Mallery,1,2 David Landry,1 Karthik Tennankore2 1Nova Scotia Health Authority, Halifax, NS, Canada; 2Dalhousie University, Halifax, NS, CanadaPurpose: Recent evidence supports the prognostic significance of frailty for functional decline and poor health outcomes in patients with chronic kidney disease. Yet, despite the development of clinical tools to screen for frailty, little is known about the experiential impact of screening for frailty in this ...

  10. 7 CFR 1416.2 - Eligible counties, hurricanes, and disaster periods.

    Science.gov (United States)

    2010-01-01

    .../29/05-10/28/05 9/23/05-11/22/05 Louisiana Madison 8/29/05-10/28/05 9/23/05-11/22/05 Louisiana... Louisiana St. James 8/29/05-10/28/05 Louisiana St. John the Baptist 8/29/05-10/28/05 Louisiana St. Landry 8... Mississippi Lowndes 8/29/05-10/28/05 9/23/05-11/22/05 Mississippi Madison 8/29/05-10/28/05 9/23/05-11/22/05...

  11. Defense AT and L. Volume 42, Number 1

    Science.gov (United States)

    2013-02-01

    Mike Kotzian, Duane Mallicoat, Tim Simpson, and Robert Landry Item-unique identification marks can be used to more efficiently manage inventory in...Evaluations themselves are conducted every 6 months at Fort Bliss , Texas, and White Sands Missile Range, N.M., they rely on a constant churn of activity in...hardware and software in close proximity, the lab is a more cost-effective environment to isolate and fix a problem than Fort Bliss and White Sands. The

  12. Members of the Forum Engelberg visit CERN

    CERN Multimedia

    Patrice Loïez

    2002-01-01

    The Forum Engelberg is an annual interdisciplinary conference held in Engelberg, Switzerland intended to act as an international platform for debate and exchange of views on key issues affecting scientific research, technology, economics and philosophy. Its President is Hubert Curien - former French Minister of Research and Space Research, and President of the CERN Council from 1994 to 1996. Photo 01: Jean-Claude Landry, Department of the Interior, Agriculture and Environment, state of Geneva (right) in discussion with Peter Jenni, spokesperson for the ATLAS collaboration.

  13. Correlated fermionic densities for many harmonically trapped particles interacting with repulsive forces

    International Nuclear Information System (INIS)

    Glasser, M.L.; March, N.H.; Nieto, L.M.

    2010-01-01

    This study is motivated by the very recent work on correlation energy as approximated by the Thomas-Fermi (TF) semiclassical limit [B.R. Landry, et al., Phys. Rev. Lett. 103 (2009) 066401]. In contrast, and motivated by the Hohenberg-Kohn theorem, our work is focussed primarily on the correlated TF ground-state density. We invoke directly the Holas et al. result that for two-fermion systems with harmonic trapping, the fermion-fermion interaction u simply adds to the trapping potential. We conclude this report with some results on correlation kinetic energy for two-fermion systems.

  14. Gordon Matta-Clark y la Anarquitectura. Documentación de su obra y análisis geométrico de sus intervenciones arquitectónicas

    OpenAIRE

    Quesada Granja, Irene Maria

    2017-01-01

    Gordon Matta-Clark formó el colectivo Anarquitectura en Nueva York (1973), junto con George Trakas, Richard Nonas, Suzanne Harris, Richard Landry, Tina Girouard, Jeffrey Lew, Bernard Kirschenbaum, Laurie Anderson, Susan Weil y Jean Dupuy. A pesar de que Matta-Clark tenía un conocimiento profundo de la construcción, su obra arquitectónica no era, en sí misma, teórica. Matta-Clark se inscribía literalmente en el edificio. Su transgresión, en este sentido, era total: desenterraba cimientos y sec...

  15. Síndrome de Guillain-Barré: patogenia, diagnóstico y cuidados críticos en pediatría

    Directory of Open Access Journals (Sweden)

    Deybis Sánchez Miranda

    2001-06-01

    Full Text Available El síndrome de Landry-Guillain-Barré-Strohl, se caracteriza por una parálisis motora ascendente o descendente bilateral con relativa simetría, hiporreflexia o arreflexia, toma bulbar, no presencia de trastornos sensitivos objetivos, síntomas disautonómicos y la parálisis respiratoria es la complicación más grave. El factor autoinmune y el fenómeno precedente tienen valor en la patogenia. El manejo de los pacientes debe ocurrir en una Unidad de Terapia Intensiva durante la fase de progresión, para el monitoreo ventilatorio y hemodinámico. Se debe garantizar nutrición, balance hidromineral neutro, control de la vía aérea y ventilación mecánica de acuerdo con los criterios clínicos, gasométricos y electrofisiológicos. La plasmaféresis, los esteroides y la gammaglobulina intravenosa parecen ser propuestas razonables de tratamiento si se utilizan en el momento adecuado.Landry-Guillain-Barré-Strohl syndrome is characterized by a bilateral ascending or descending motor paralysis with relative simmetry, hyporeflexia or areflexia, bulbar taking, no objective sensitive disorders, disautonomic symptoms and respiratory paralysis, which is the most severe complication. The autoimmune factor and the preceeding phenomenon have value in the pathogeny. Patients should be managed in an Intensive Care Unit during the progression stage for the ventilatory and hemodynamic monitoring. Nutrition, neutral hydromineral balance, control of the airways and mechanical ventilation should be guaranteed according to the clinical, gasometric and electrophysiological criteria. Plasmapheresis, steroids and intravenous gammaglobulins appear to be reasonable suggestions for treatment if they are used at the right time.

  16. Aporte de hojarasca y renovación foliar del manglar en un sistema estuarino del Sureste de México

    Directory of Open Access Journals (Sweden)

    Ma. Teresa Barreiro-Güemes

    1999-12-01

    Full Text Available Los patrones de producción de hojarasca fueron estudiados en Pom-Atasta, un sistema estuarino asociado a la Laguna de Términos Campeche, México. Se seleccionaron cuatro rodales de manglar, contrastantes por sus condiciones de influencia de marea. Se colocaron al azar diez trampas en cada sitio para la colecta de hojarasca, estas fueron revisadas a intervalos mensuales durante un ciclo anual (1995-96. El material recolectado fue clasificado, secado y pesado. La floración de Avicennia germinans se presentó desde junio hasta septiembre; Rhizophora mangle presentó flores e hipocotilos todo el año. Los bosques más productivos fueron los ribereños dominados por A. germinans en la zona de menor influencia de marea, con condiciones hipohalinas de escasa variación anual y substratos limo-arcillosos. La producción promedio de hojarasca varió entre 1.8 y 4.5 g m-2 dìa-1. y respondió a los periodos climáticos de la región. En octubre de 1995 los ciclones Roxane y Opal se presentaron en la región y causaron una extraordinaria defoliación con aportes de hojarasca de 8 a 12 g m-2día-1 cifras que exceden a las registradas para manglares de México, del Caribe y del Ecuador. La tasa de renovación de follaje fue de 129-392 días.The patterns of mangrove litter production were studied in Pom-Atasta, a estuarine system linked to Terminos Lagoon, Campeche coast, Mexico. Four sampling sites with contrasting conditions of tidal influence were selected. Ten litter baskets placed randomly in each site for litter fall evaluation, were emptied monthly during an annual cycle (1995-1996. Litter material was classified, dried and weighed. The flowering season for Avicennia germinans was from June through September; Rhizophora mangle had flowers and hypocotyls year round. The most productive site was riverine forest dominated by A. germinans in the area with least tidal influence and hypohaline conditions, low annual salinity variation and lime-clay soils

  17. Kuus turundusüksuse tüüpi / Edward Landry, Andrew Tipping, Brodie Dixon

    Index Scriptorium Estoniae

    Landry, Edward

    2005-01-01

    Konsultatsioonifirma Booz Allen Hamilton ja Association of National Advertisers välja töötatud turundusüksuste tüüpidest ja asjaoludest, mida peaks arvesse võtma firma olemasoleva turundusüksuse välja selgitamiseks

  18. Seasonal and spatial variations in settling manganese fluxes in the northern Arabian Sea

    Digital Repository Service at National Institute of Oceanography (India)

    Nair, T.M.B.; Ramaswamy, V.; Shankar, R; Ittekkot, V.

    , which is as redox sensitive as Mn, T.M. Balakrishnan Nair et al. / Deep-Sea Research I 46 (1999) 1827}1839 1831 F i g. 2 . S p at ial v a r ia ti on in s e t t l i ng M n %9 an d M n $5 # ux e s i n t h e A r a b i a n S e a . 1832 T.M. Balakrishnan Nair... and its importance to the microbial food web of the North western Indian Ocean. Deep-Sea Research II 40, 773}782. Campbell, L., Landry, M.R., Constantinou, J., Nolla, H.A., Brown, S.L., Liu, H., Caron, D.A., 1998. Response of microbial community structure...

  19. Members of the Forum Engelberg visit CERN

    CERN Multimedia

    Patrice Loïez

    2002-01-01

    The Forum Engelberg is an annual interdisciplinary conference held in Engelberg, Switzerland intended to act as an international platform for debate and exchange of views on key issues affecting scientific research, technology, economics and philosophy. Its President is Hubert Curien - former French Minister of Research and Space Research, and President of the CERN Council from 1994 to 1996. He is pictured here (centre) with (left to right) Raymond Battistella, Director-General of SIG, Geneva's utilities provider; Michel Della Negra; Marie-Anne Heimo; Jean-Claude Landry; and Bernard Ecoffey, Founder of the Forum Engelberg, in front of the CMS detector under construction. Visible are three of the five concentric rings forming the barrel yoke which returns the magnetic flux generated by the superconducting coil.

  20. Members of the Forum Engelberg visit CERN

    CERN Multimedia

    Patrive Loïez

    2002-01-01

    The Forum Engelberg is an annual interdisciplinary conference held in Engelberg, Switzerland intended to act as an international platform for debate and exchange of views on key issues affecting scientific research, technology, economics and philosophy. Its President is Hubert Curien - former French Minister of Research and Space Research, and President of the CERN Council from 1994 to 1996. Photo 01: CERN Director-General Prof. Luciano Maiani (left) speaks to Forum members and public figures from the Geneva area during the visit. In the background is Jean-Claude Landry from the Department of the Interior, Agriculture and Environment, State of Geneva. Photo 02: CERN Director-General Prof. Luciano Maiani (left) speaks to Forum members and public figures from the Geneva area during the visit. In the background is Bernard Ecoffey, Founder of the Forum Engelberg.

  1. Plutella australiana (Lepidoptera, Plutellidae), an overlooked diamondback moth revealed by DNA barcodes.

    Science.gov (United States)

    Landry, Jean-François; Hebert, Paul Dn

    2013-01-01

    The genus Plutella was thought to be represented in Australia by a single introduced species, Plutella xylostella (Linnaeus), the diamondback moth. Its status as a major pest of cruciferous crops, and the difficulty in developing control strategies has motivated broad-ranging studies on its biology. Prior genetic work has generally supported the conclusion that populations of this migratory species are connected by substantial gene flow. However, the present study reveals the presence of two genetically divergent lineages of this taxonin Australia. One shows close genetic and morphological similarity with the nearly cosmopolitan Plutella xylostella. The second lineage possesses a similar external morphology, but marked sequence divergence in the barcode region of the cytochrome c oxidase I gene, coupled with clear differences in genitalia. As a consequence, members of this lineage are described as a new species, Plutella australiana Landry & Hebert, which is broadly distributed in the eastern half of Australia.

  2. Retrospective analysis of co-occurrence of congenital aortic stenosis and pulmonary artery stenosis in dogs.

    Science.gov (United States)

    Kander, M; Pasławska, U; Staszczyk, M; Cepiel, A; Pasławski, R; Mazur, G; Noszczyk-Nowak, A

    2015-01-01

    The study has focused on the retrospective analysis of cases of coexisting congenital aortic stenosis (AS) and pulmonary artery stenosis (PS) in dogs. The research included 5463 dogs which were referred for cardiological examination (including clinical examination, ECG and echocardiography) between 2004 and 2014. Aortic stenosis and PS stenosis were detected in 31 dogs. This complex defect was the most commonly diagnosed in Boxers - 7 dogs, other breeds were represented by: 4 cross-breed dogs, 2 Bichon Maltais, 3 Miniature Pinschers, 2 Bernese Mountain Dogs, 2 French Bulldogs, and individuals of following breeds: Bichon Frise, Bull Terrier, Czech Wolfdog, German Shepherd, Hairless Chinese Crested Dog, Miniature Schnauzer, Pug, Rottweiler, Samoyed, West Highland White Terrier and Yorkshire Terrier. In all the dogs, the murmurs could be heard, graded from 2 to 5 (on a scale of 1-6). Besides, in 9 cases other congenital defects were diagnosed: patent ductus arteriosus, mitral valve dysplasia, pulmonary or aortic valve regurgitation, tricuspid valve dysplasia, ventricular or atrial septal defect. The majority of the dogs suffered from pulmonary valvular stenosis (1 dog had supravalvular pulmonary artery stenosis) and subvalvular aortic stenosis (2 dogs had valvular aortic stenosis). Conclusions and clinical relevance - co-occurrence of AS and PS is the most common complex congenital heart defect. Boxer breed was predisposed to this complex defect. It was found that coexisting AS and PS is more common in male dogs and the degree of PS and AS was mostly similar.

  3. Evaluation of the Stability of Mercaptopurine Suspension Compounded in a Commercial Vehicle and the Determination of an Appropriate Beyond-use Date.

    Science.gov (United States)

    Peacock, Gina F; Sauvageot, Jurgita; Hill, Ashley; Killian, Alyssa

    2016-01-01

    Mercaptopurine is commonly used to treat acute lymphoblastic leukemia and has historically been commercially available only in tablet form. Since tablets may be difficult for children and elderly patients to swallow, many pharmacists have compounded mercaptopurine suspensions. The U.S. Food and Drug Administration recently approved a commercial suspension, but it is not widely available at this time. Therefore, pharmacists may still need to compound mercaptopurine suspension for use in areas where it is not available or if the commercial suspension is in short supply. Stability studies must be conducted in order to assign appropriate beyond-use dates for compounded preparations. The objective of this study was to evaluate the stability of extemporaneously compounded suspensions using commercially available mercaptopurine tablets, as well as active pharmaceutical ingredient in a vehicle of Ora-Sweet and Ora-Plus (1:1) stored in plastic and glass containers at room temperature. Each mercaptopurine preparation was analyzed using a validated stability-indicating high-performance liquid chromatography method at the following time points: 0, 7, 14, 21, 30, 60, and 90 days. Suspensions were also observed for changes in appearance or odor, and pH was tested at each time point. The suspension compounded from Roxane generic tablets was extremely viscous and was therefore eliminated from the study. All other suspensions showed no observed physical changes and maintained greater than 93% of initial concentration of mercaptopurine for the entire study period.

  4. Plutella australiana (Lepidoptera, Plutellidae), an overlooked diamondback moth revealed by DNA barcodes

    Science.gov (United States)

    Landry, Jean-François; Hebert, Paul DN

    2013-01-01

    Abstract The genus Plutella was thought to be represented in Australia by a single introduced species, Plutella xylostella (Linnaeus), the diamondback moth. Its status as a major pest of cruciferous crops, and the difficulty in developing control strategies has motivated broad-ranging studies on its biology. Prior genetic work has generally supported the conclusion that populations of this migratory species are connected by substantial gene flow. However, the present study reveals the presence of two genetically divergent lineages of this taxonin Australia. One shows close genetic and morphological similarity with the nearly cosmopolitan Plutella xylostella. The second lineage possesses a similar external morphology, but marked sequence divergence in the barcode region of the cytochrome c oxidase I gene, coupled with clear differences in genitalia. As a consequence, members of this lineage are described as a new species, Plutella australiana Landry & Hebert, which is broadly distributed in the eastern half of Australia. PMID:24167421

  5. Supporting parents and parenting: An overview of data-based papers recently published in Contemporary Nurse.

    Science.gov (United States)

    Jackson, Debra; Power, Tamara; Dean, Sue; Potgieter, Ingrid; Cleary, Michelle

    2013-10-02

    Abstract Nurses have a crucial role in play in supporting parents and in delivering and referring parents to family-support services. In this editorial, we reflect on papers recently published in Contemporary Nurse. We sought to consider data-based papers on parenting published between 2008 and 2012 and elucidate the role/s and potential roles of nurses in enhancing and supporting parenting. Parenting is recognised as a crucial variable for achieving positive outcomes for children (Dawson et al 2012). Poor, inconsistent or abusive parenting is linked to poor outcomes (Griffin et al. 2000, Holt et al.2008, Patterson et al.1989), while consistent and effective parenting is associated with enhanced child outcomes (Lamb 2012, Landry et al.2001). In addition to being important to outcomes for children, perceived parenting quality is also important to parents themselves. Disrupted relationships between parents and their children have been identified as distressing and potentially damaging to both parties (Jackson 2000; East 2006, 2007; Power 2012).

  6. 2006 - 2007 ACADEMIC TRAINING PROGRAMME

    CERN Multimedia

    2006-01-01

    1st Term: 02.10. 2006 - 15.12.2006 LECTURE SERIES Practical statistics for particle physicists by L. Lyons, Univ. Oxford, GB 9, 10, 11, 12, 13 October 11:00 -12:00 - Main Auditorium, Bldg 500 Gravitational waves by M. Landry, LIGO Hanford Observatory, Richland, USA 16, 17, 18 October 11:00-12:00 - Main Auditorium, Bldg 500 Neutrino physics, past and future by B. Kayser, FERMILAB, Batavia, USA 27, 28, 29, 30 November, 1 December 11:00-12:00 - TH Auditorium, Bldg 4, 3rd Floor QCD: are we ready for the LHC by S. Frixione, INFN, Genoa, It 4, 5, 6, 7 December 11:00-12:00 - Auditorium, Bldg 500 The abstract of the lectures, as well as any change to the above information (title, dates, time, place etc.) will be published in the CERN bulletin, the WWW, and by Notices before each term and for each series of lectures. ENSEIGNEMENT ACADEMIQUE ACADEMIC TRAINING Françoise Benz 73127 academic.training@cern.ch

  7. LINGUISTIC LANDSCPAE OF TBILISI: A CASE STUDY OF GRAFFITI

    Directory of Open Access Journals (Sweden)

    Jūratė Radavičiūtė

    2017-10-01

    Full Text Available The article investigates graffiti of Tbilisi, Georgia, as a part of the linguistic landscape of the city. The research is carried out within the theoretical framework of linguistic landscape, based on the works by Landry and Bourhis (1997, Gorter (2006, Jaworski and Thurlow (2010, etc. The aspects of multimodality, multilingualism and sociality are focused on in the research. The graffiti analysed displays the features of multimodality where visual images are used alongside with written texts, thus, adding the element of complexity to the discourse investigated. It must be pointed out that the use of English language for graffiti making prevails. Regarding the social aspect of the linguistic landscape, Tbilisi graffiti shows the engagement of street artists in a socially-relevant discussion tackling both local and state-level problems. The display of Tbilisi graffiti demonstrates the fluidity of this type of narrative: older graffiti are covered with new ones in addition to being cleaned or covered with official or commercial signage.

  8. “Hindi Bayani/Not a Hero”: The Linguistic Landscape of Protest in Manila

    Directory of Open Access Journals (Sweden)

    Jennifer Monje

    2017-12-01

    Full Text Available This article examines the linguistic landscape of Manila during a protest march in November 2016 in response to the burial of deposed president Ferdinand Marcos at the Libingan ng mga Bayani (Heroes’ Cemetery. This article is situated among linguistic landscape of protest research (Kasanga, 2014; Seals, 2011; Shiri, 2015 where data is composed of mobile posters, placards, banners, and other ‘unfixed’ signs, including texts on bodies, t-shirts, umbrellas, and rocks. Following Sebba (2010, this article argues that both ‘fixed’ linguistic landscape and ‘mobile’ public texts are indices of the linguistic composition of cities, linguistic diversity, and ethnolinguistic vitality (Landry & Bourhis, 1997. Through a qualitative analysis of selected pictures produced during the protest march and uploaded onto social media, the multilingual nature of Manila is rendered salient and visible, albeit temporarily, and strategies of dissent are reflective of the language of the millennials who populated the protests.

  9. Academic Training: Gravitational Waves Astronomy

    CERN Multimedia

    2006-01-01

    2006-2007 ACADEMIC TRAINING PROGRAMME LECTURE SERIES 16, 17, 18 October from 11:00 to 12:00 - Main Auditorium, bldg. 500 Gravitational Waves Astronomy M. LANDRY, LIGO Hanford Observatory, Richland, USA Gravitational wave astronomy is expected to become an observational field within the next decade. First direct detection of gravitational waves is possible with existing terrestrial-based detectors, and highly probable with proposed upgrades. In this three-part lecture series, we give an overview of the field, including material on gravitional wave sources, detection methods, some details of interferometric detectors, data analysis methods, and current results from observational data-taking runs of the LIGO and GEO projects. ENSEIGNEMENT ACADEMIQUE ACADEMIC TRAINING Françoise Benz 73127 academic.training@cern.ch If you wish to participate in one of the following courses, please tell to your supervisor and apply electronically from the course description pages that can be found on the Web at: http://www...

  10. Academic Training: Gravitational Waves Astronomy

    CERN Multimedia

    2006-01-01

    2006-2007 ACADEMIC TRAINING PROGRAMME LECTURE SERIES 16, 17, 18 October from 11:00 to 12:00 - Main Auditorium, bldg. 500 Gravitational Waves Astronomy M. LANDRY, LIGO Hanford Observatory, Richland, USA Gravitational wave astronomy is expected to become an observational field within the next decade. First direct detection of gravitational waves is possible with existing terrestrial-based detectors, and highly probable with proposed upgrades. In this three-part lecture series, we give an overview of the field, including material on gravitional wave sources, detection methods, some details of interferometric detectors, data analysis methods, and current results from observational data-taking runs of the LIGO and GEO projects.ENSEIGNEMENT ACADEMIQUE ACADEMIC TRAINING Françoise Benz 73127 academic.training@cern.ch If you wish to participate in one of the following courses, please tell to your supervisor and apply electronically from the course description pages that can be found on the Web at: http://www.cern...

  11. Spatial and Temporal Assessment on Drug Addiction Using Multivariate Analysis and GIS

    International Nuclear Information System (INIS)

    Mohd Ekhwan Toriman; Mohd Ekhwan Toriman; Siti Nor Fazillah Abdullah; Izwan Arif Azizan; Mohd Khairul Amri Kamarudin; Roslan Umar; Nasir Mohamad

    2015-01-01

    There is a need for managing and displaying drug addiction phenomena and trend at both spatial and temporal scales. Spatial and temporal assessment on drug addiction in Terengganu was undertaken to understand the geographical area of district in the same cluster, in addition, identify the hot spot area of this problem and analysis the trend of drug addiction. Data used were topography map of Terengganu and number of drug addicted person in Terengganu by district within 10 years (2004-2013). Number of drug addicted person by district were mapped using Geographic Information system and analysed using a combination of multivariate analysis which is cluster analysis were applied to the database in order to validate the correlation between data in the same cluster. Result showed a cluster analysis for number of drug addiction by district generated three clusters which are Besut and Kuala Terengganu in cluster 1 named moderate drug addicted person (MDA), Dungun, Marang, Setiu and Hulu Terengganu in cluster 2 named lower drug addicted person (LDA) and Kemaman in cluster 3 named high drug addicted person(HDA). This analysis indicates that cluster 3 which is Kemaman is a hot spot area. These results were beneficial for stakeholder to monitor and manage this problem especially in the hot spot area which needs to be emphasized. (author)

  12. Potential for Osseous Regeneration of Platelet-Rich Fibrin-A Comparative Study in Mandibular Third Molar Impaction Sockets.

    Science.gov (United States)

    Varghese, Mathew P; Manuel, Suvy; Kumar L K, Surej

    2017-07-01

    This study investigated the potential of platelet-rich fibrin (PRF) for osseous regeneration and soft tissue healing in mandibular third molar impaction sockets. A prospective in vivo study was performed. Randomization was performed after extraction. On one side, the socket was sutured primarily (control site); on the other side, autologous PRF gel was placed and then the socket was sutured (test site). Postoperatively, grid periapical radiographs were obtained at periodic intervals (weeks 1, 4, and 16) and digitalized. Gray-level values were measured at 3 different regions of the socket (for regions of newly formed bone) compared with the natural bone area using HL Image++ software, and the percentage bone fill was measured. Clinical evaluation of soft tissue healing was performed using the healing index of Landry et al (J Periodontol 60:212, 1994) at the specific intervals. Thirty healthy men and women (age range, 18 to 35 yr) with bilaterally impacted mandibular third molars were enrolled in this study. In general, there was markedly greater bone formation in sockets treated with PRF (P < .05). In the PRF group, the average gray-level values at the cervical, middle, and apical regions were 61.85 (standard deviation [SD], ±25.186), 64.54 (SD, ±24.831), and 67.80 (SD, ±23.946), respectively, with a mean value of 64.73 (SD, ±24.411). In the control group, these values were 51.58 (SD, ±15.286), 54.30 (SD, ±16.274), and 57.53 (SD, ±16.187), respectively, with a mean of 53.67 (SD, ±16.528). The average percentage of bone fill in the PRF group was 57.90 (SD, ±26.789) and that of the non-PRF group was 46.74 (SD, ±17.713; P < .05). Soft tissue healing as evaluated by the healing index of Landry et al also was found to be better at the PRF test site and it was statistically significant (P < .05). There was evidence for better osseous regeneration and soft tissue healing in response to PRF. Further investigations to evaluate the application of PRF in other

  13. Social Media and Sexual Behavior Among Adolescents: Is there a link?

    Science.gov (United States)

    Landry, Megan; Turner, Monique; Vyas, Amita; Wood, Susan

    2017-05-19

    Adolescent sexual risk taking and its consequences remain a global public health concern. Empirical evidence on the impact that social media has on sexual health behaviors among youth is sparse. The study aimed to examine the relationship between social media and the change in sexual risk over time and whether parental monitoring moderates this relationship. This study comprised a sample of 555 Latino youth aged 13-19 years from Maryland, United States completing baseline and follow-up surveys. Mixed-effects linear regression was used to examine the relationship between social media and the change in sexual risk over time and whether parental monitoring moderated the relationship. Sexual risk behaviors significantly increased between baseline (T1) and follow up (T2) (mean=0.432 vs mean=0.734, PYouth sending more than 100 text messages per day had significantly higher sexual risk scores (beta=1.008, Pinfluence diminishing and peer pressure and social influences increasing during adolescence. ©Megan Landry, Monique Turner, Amita Vyas, Susan Wood. Originally published in JMIR Public Health and Surveillance (http://publichealth.jmir.org), 19.05.2017.

  14. Landry Ebang, La logique de l’enquête en science sociale. Sortir d’une méthodologie du mimétisme expérimental

    OpenAIRE

    Ogorzelec-Guinchard, Laetitia

    2014-01-01

    L’auteur présente cet ouvrage comme un « traité de méthodologie » explicitement adossé à une démarche de philosophie des sciences. Il s’agit pour lui de procéder à un examen de l’intégralité du processus de recherche en sciences sociales. La première partie du livre cherche surtout à nous expliquer à quel point la « méthode expérimentale » propre aux sciences « nomologiques » (c’est-à-dire capables de formuler des lois et d’en tirer toutes les conséquences dans leurs démarches de recherche) b...

  15. Pathogenesis of hyperinflation in chronic obstructive pulmonary disease

    Directory of Open Access Journals (Sweden)

    Gagnon P

    2014-02-01

    Full Text Available Philippe Gagnon,1,2 Jordan A Guenette,3,4 Daniel Langer,5 Louis Laviolette,2 Vincent Mainguy,1 François Maltais,1,2 Fernanda Ribeiro,1,2 Didier Saey1,2 1Faculté de Médecine, Université Laval, 2Centre de Recherche, Institut Universitaire de Cardiologie et de Pneumologie de Québec, Université Laval, Québec, QC, 3Centre for Heart Lung Innovation, University of British Columbia, St Paul's Hospital, 4Department of Physical Therapy, University of British Columbia, Vancouver, BC, Canada; 5Department of Kinesiology and Rehabilitation Sciences, KU Leuven, Leuven, Belgium Abstract: Chronic obstructive pulmonary disease (COPD is a preventable and treatable lung disease characterized by airflow limitation that is not fully reversible. In a significant proportion of patients with COPD, reduced lung elastic recoil combined with expiratory flow limitation leads to lung hyperinflation during the course of the disease. Development of hyperinflation during the course of COPD is insidious. Dynamic hyperinflation is highly prevalent in the advanced stages of COPD, and new evidence suggests that it also occurs in many patients with mild disease, independently of the presence of resting hyperinflation. Hyperinflation is clinically relevant for patients with COPD mainly because it contributes to dyspnea, exercise intolerance, skeletal muscle limitations, morbidity, and reduced physical activity levels associated with the disease. Various pharmacological and nonpharmacological interventions have been shown to reduce hyperinflation and delay the onset of ventilatory limitation in patients with COPD. The aim of this review is to address the more recent literature regarding the pathogenesis, assessment, and management of both static and dynamic lung hyperinflation in patients with COPD. We also address the influence of biological sex and obesity and new developments in our understanding of hyperinflation in patients with mild COPD and its evolution during

  16. Correlation Of Terrestrial gamma flashes, Electric fields, and Lightning strikes (COTEL) in thunderstorms using networked balloon payloads developed by university and community college students

    Science.gov (United States)

    Landry, B. J.; Blair, D.; Causey, J.; Collins, J.; Davis, A.; Fernandez-Kim, V.; Kennedy, J.; Pate, N.; Kearney, C.; Schayer, C.; Turk, E.; Cherry, M. L.; Fava, C.; Granger, D.; Stewart, M.; Guzik, T. G.

    2017-12-01

    High energy gamma ray flashes from terrestrial sources have been observed by satellites for decades, but the actual mechanism, assumed to be thunderstorm lightning, has yet to be fully characterized. The goal of COTEL, funded by NASA through the University Student Instrument Project (USIP) program, is to correlate in time TGF events, lightning strikes, and electric fields inside of thunderstorms. This will be accomplished using a small network of balloon-borne payloads suspended in and around thunderstorm environments. The payloads will detect and timestamp gamma radiation bursts, lightning strikes, and the intensity of localized electric fields. While in flight, data collected by the payloads will be transmitted to a ground station in real-time and will be analyzed post-flight to investigate potential correlations between lightning, TGFs, and electric fields. The COTEL student team is in its second year of effort having spent the first year developing the basic balloon payloads and ground tracking system. Currently the team is focusing on prototype electric field and gamma radiation detectors. Testing and development of these systems will continue into 2018, and flight operations will take place during the spring 2018 Louisiana thunderstorm season. The presentation, led by undergraduate Physics student Brad Landry, will cover the student team effort in developing the COTEL system, an overview of the system architecture, balloon flight tests conducted to date, preliminary results from prototype detectors, lessons learned for student-led science projects, and future plans.

  17. Body weight status of school adolescents in Terengganu, Malaysia: a population baseline study.

    Science.gov (United States)

    Ahmad, Aryati; Zulaily, Nurzaime; Abdul Manan, Nor Saidah; Shahril, Mohd Razif; Syed Saadun Tarek Wafa, Sharifah Wajihah Wafa; Mohd Amin, Rahmah; Syed Abdullah, Engku Fadzli Hasan; Ahmed, Amran

    2017-01-05

    Body weight is highly associated with overall health status. Being severely thin or obese may impose the risk of many health problems. Early detection of body mass index (BMI) status may help to reduce the associated comorbidities. Although many studies in the literature have investigated the BMI of school adolescents in Malaysia, the data on status of body weight among school adolescents in suburban states like Terengganu is limited. This study aimed to describe the body weight status of the whole population of school adolescents in all seven districts in Terengganu, Malaysia. Using a cross-sectional study design, body weight and height were measured, and BMI was calculated and classified using WHO BMI-for-age Z-score. Data was obtained using the National Fitness Standard (SEGAK) assessment, which was uploaded in a specific Health Monitoring System (HEMS). From a total of 62,567 school adolescents, 50.7% were boys and 49.3% were girls. Girls had significantly higher BMI than boys in age groups of 13 to 15 and 16 to 17 years old. Among boys and girls, there were significant differences in mean BMI of school adolescents between rural and urban school locations in all age groups (p < 0.001). There were also significant differences in BMI between boys and girls in all districts in Terengganu, except Kemaman and Kuala Terengganu, for all age groups (p < 0.001). Overall, the prevalence of thinness, normal, overweight and obesity were 8.4, 64.6, 15.0 and 12.0%, respectively. There were significant differences between BMI categories and genders in total participants, and within rural and urban school locations (p < 0.05). In all districts except Marang and Dungun, significant difference was also found between BMI categories and genders. The prevalence of thinness, overweight and obesity in Terengganu were substantial. In this study, BMI category was associated with gender, age, school location and district. However, the actual effects of these factors on the

  18. Wine and Cheese: Two Products or One Association? A New Method for Assessing Wine-Cheese Pairing

    Directory of Open Access Journals (Sweden)

    Mara V. Galmarini

    2018-02-01

    Full Text Available The aim of this study was to identify which attributes impacted the dynamic liking of cheese and wine individually, as well as when consumed together. Three wines (one white, Pouilly Loché; and two red, Maranges and Beaujolais and three cheeses (Comté, Époisses, Chaource were individually evaluated by a group of 60 consumers using mono-intake Temporal Dominance of Sensations (TDS with simultaneous hedonic ratings. The same data acquisition screen was used for all products showing a unique list of 14 descriptors (covering cheese and wine perception and a hedonic scale for dynamical rating of liking. The dynamic hedonic data were associated with the TDS profiles obtaining Temporal Drivers of Liking (TDL. Furthermore, the nine associations that resulted from combining each wine with each cheese were evaluated by multi-bite and multi-sip TDS. Individually, Chaource had practically no TDL; for Comté, mushroom flavor was a positive TDL, and in Époisses, salty was a negative TDL. As for wines, negative TDL were only found in the red wines: bitter, sour and astringent. Positive TDL for wines were: fruity, spicy and woody. Changes in the dynamic perception had a bigger impact on liking of wine compared to cheese. For the associations, the negative TDL were only three and mostly wine related: sour (for seven out of nine combinations, bitter (six out of nine and astringent (five out of nine. Positive TDL were more varied (a total of 10 descriptors and were related either to wine or cheese. As opposed to what was found in cheese alone, salty was a positive TDL in two of the combinations. It was observed that the dynamic sensory perception had a more important impact on liking in wine-cheese combinations than when consumed separately. TDS and TDL have a big potential in the study of food pairing, which should be further exploited.

  19. Body weight status of school adolescents in Terengganu, Malaysia: a population baseline study

    Directory of Open Access Journals (Sweden)

    Aryati Ahmad

    2017-01-01

    Full Text Available Abstract Background Body weight is highly associated with overall health status. Being severely thin or obese may impose the risk of many health problems. Early detection of body mass index (BMI status may help to reduce the associated comorbidities. Although many studies in the literature have investigated the BMI of school adolescents in Malaysia, the data on status of body weight among school adolescents in suburban states like Terengganu is limited. This study aimed to describe the body weight status of the whole population of school adolescents in all seven districts in Terengganu, Malaysia. Methods Using a cross-sectional study design, body weight and height were measured, and BMI was calculated and classified using WHO BMI-for-age Z-score. Data was obtained using the National Fitness Standard (SEGAK assessment, which was uploaded in a specific Health Monitoring System (HEMS. Results From a total of 62,567 school adolescents, 50.7% were boys and 49.3% were girls. Girls had significantly higher BMI than boys in age groups of 13 to 15 and 16 to 17 years old. Among boys and girls, there were significant differences in mean BMI of school adolescents between rural and urban school locations in all age groups (p < 0.001. There were also significant differences in BMI between boys and girls in all districts in Terengganu, except Kemaman and Kuala Terengganu, for all age groups (p < 0.001. Overall, the prevalence of thinness, normal, overweight and obesity were 8.4, 64.6, 15.0 and 12.0%, respectively. There were significant differences between BMI categories and genders in total participants, and within rural and urban school locations (p < 0.05. In all districts except Marang and Dungun, significant difference was also found between BMI categories and genders. Conclusion The prevalence of thinness, overweight and obesity in Terengganu were substantial. In this study, BMI category was associated with gender, age, school location and

  20. Four Approaches to the Creative Economy: General Overview Keturi požiūriai į kūrybos ekonomiką: bendroji apžvalga

    Directory of Open Access Journals (Sweden)

    Rasa Levickaitė

    2011-06-01

    Full Text Available

    The article presents the concept of the creative economy as a new economic phenomenon in the globalized environment. Four approaches on the new occurrence are presented. According to John Howkins theory, the fifteen creative industries (listed by the author are the core of the creative economy. Both creativity and economy aren’t new, but brand new are its interaction and scope. A wide definition of creativity has formed Richard Florida’s theory of the developing creative class, which is a group of professionals, researchers and artists whose presence creates socioeconomic and cultural dynamism in cities especially. Richard Caves characterizes creative industries on the basis of seven economic properties and presents an idea that creative industries as such aren’t unique but the sectors of creative industries driven by creativity generate new approaches to business processes, the demand-supply chain and covers both economic and social indicators of the country development. Charles Landry has proposed a creative city concept, which states that cities are dependent on one resource only – its people. Creativity changes place, natural resources, market access, and becomes the key to dynamism of city development. A creative city defines a metropolis with variety of cultural activities glued to urban economical and social functioning. Key activities highly influencing rapid growth of the creative industries worldwide are related to both technology and economy. Digital revolutions and economic environments where revolutions took place, changes in technology and communications altogether have formed new conditions for development of creative economy as a new economic phenomenon.

    Article in English

    Straipsnyje pristatoma kūrybos ekonomikos koncepcija, kūrybos ekonomikos reiškinys analizuojamas globalioje aplinkoje. Pateikiama keturių požiūrių į kūrybos ekonomiką apžvalga: Johno Howkinso (2007 teorija remiasi paties

  1. Building Energy-Efficient Schools in New Orleans: Lessons Learned (Brochure)

    Energy Technology Data Exchange (ETDEWEB)

    2011-12-01

    This case study presents the lessons learned from incorporating energy efficiency in the rebuilding and renovating of New Orleans K-12 schools after Hurricanes Katrina and Rita. Hurricane Katrina was the largest natural disaster in the United States, striking the Gulf Coast on August 29, 2005, and flooding 80% of New Orleans; to make matters worse, the city was flooded again only three weeks later by the effects of Hurricane Rita. Many of the buildings, including schools, were heavily damaged. The devastation of schools in New Orleans from the hurricanes was exacerbated by many years of deferred school maintenance. This case study presents the lessons learned from incorporating energy efficiency in the rebuilding and renovating of New Orleans K-12 schools after Hurricanes Katrina and Rita. The experiences of four new schools-Langston Hughes Elementary School, Andrew H. Wilson Elementary School (which was 50% new construction and 50% major renovation), L.B. Landry High School, and Lake Area High School-and one major renovation, Joseph A. Craig Elementary School-are described to help other school districts and design teams with their in-progress and future school building projects in hot-humid climates. Before Hurricane Katrina, New Orleans had 128 public schools. As part of the recovery planning, New Orleans Public Schools underwent an assessment and planning process to determine how many schools were needed and in what locations. Following a series of public town hall meetings and a district-wide comprehensive facility assessment, a Master Plan was developed, which outlined the renovation or construction of 85 schools throughout the city, which are expected to be completed by 2017. New Orleans Public Schools expects to build or renovate approximately eight schools each year over a 10-year period to achieve 21st century schools district-wide. Reconstruction costs are estimated at nearly $2 billion.

  2. Holistic Healing Through Herbs: Effectiveness of Aloe Vera on Post Extraction Socket Healing.

    Science.gov (United States)

    Nimma, Vijaya Lakshmi; Talla, Harsha Vardhan; Bairi, Jaya Krishna; Gopaldas, Madhulatha; Bathula, Haritha; Vangdoth, Sandeep

    2017-03-01

    Advances in the field of alternative medicine has encouraged the use of various natural products for multiple uses in the field of dentistry for treatment of various oral diseases. A natural herbal product is Aloe vera, which has number of benefits with no reported side effects and gaining considerable importance in clinical research. The aim of this cross-sectional randomized interventional study was to evaluate the effectiveness of Aloe vera in the healing of post extraction sockets. A sample size of 40 patients undergoing atraumatic extraction was divided into two groups. Group A-patients were prescribed only analgesics and followed for seven consecutive days and socket healing assessment was done. Group B-Patients were given Aloe vera soaked gel foams, followed up to the third and seventh day by two observers and the socket healing was assessed using the standardized index by Landry, Turnbull and Howley. In addition to healing the common complaint associated with extraction wound, the pain was assessed using numerical rating scale. Data obtained was statistically analysed using Mann-whitney U test, Wilcoxon Signed ranks test and Spearman's rank correlation method. Control group on the third and the seventh day showed healing of 60% and 70% respectively and the Aloe vera group showed a better result having a healing potential of 70% on the third day and 90% on the seventh day which was statistically significant with a (p-valueAloe vera group showed a significant decrease in pain after two hours on the day of extraction followed by second, third and seventh day which was statistically significant (p-valueAloe vera has been proved to have a unique property that is implicated in better healing than other group without any side effects. Aloe vera is economical, effective, powerful nutritional supplement and antioxidant that protects and promotes wound healing.

  3. Holistic Healing Through Herbs: Effectiveness of Aloe Vera on Post Extraction Socket Healing

    Science.gov (United States)

    Talla, Harsha Vardhan; Bairi, Jaya Krishna; Gopaldas, Madhulatha; Bathula, Haritha; Vangdoth, Sandeep

    2017-01-01

    Introduction Advances in the field of alternative medicine has encouraged the use of various natural products for multiple uses in the field of dentistry for treatment of various oral diseases. A natural herbal product is Aloe vera, which has number of benefits with no reported side effects and gaining considerable importance in clinical research. Aim The aim of this cross-sectional randomized interventional study was to evaluate the effectiveness of Aloe vera in the healing of post extraction sockets. Materials and Methods A sample size of 40 patients undergoing atraumatic extraction was divided into two groups. Group A-patients were prescribed only analgesics and followed for seven consecutive days and socket healing assessment was done. Group B-Patients were given Aloe vera soaked gel foams, followed up to the third and seventh day by two observers and the socket healing was assessed using the standardized index by Landry, Turnbull and Howley. In addition to healing the common complaint associated with extraction wound, the pain was assessed using numerical rating scale. Data obtained was statistically analysed using Mann-whitney U test, Wilcoxon Signed ranks test and Spearman’s rank correlation method. Results Control group on the third and the seventh day showed healing of 60% and 70% respectively and the Aloe vera group showed a better result having a healing potential of 70% on the third day and 90% on the seventh day which was statistically significant with a (p-valueAloe vera group showed a significant decrease in pain after two hours on the day of extraction followed by second, third and seventh day which was statistically significant (p-valueAloe vera has been proved to have a unique property that is implicated in better healing than other group without any side effects. Aloe vera is economical, effective, powerful nutritional supplement and antioxidant that protects and promotes wound healing. PMID:28511517

  4. The SOFeX Group

    Science.gov (United States)

    Coale, K. H.

    2002-12-01

    The SOFeX Group is comprised of the following institutions and individuals, all of whose participation resulted in a successful experiment. Moss Landing Marine Laboratories: K. Coale, C. Hunter, M. Gordon, S. Tanner, W. Wang, N. Ladizinsky, D. Cooper, G. Smith, J. Brewster; Monterey Bay Aquarium Research Institute: K. Johnson, F. Chavez, S. Fitzwater, P. Strutton, G. Elrod, Z. Chase, E. Drake, J. Plant; Oregon State University: B. Hales, J. Barth, L.Bandstra, P. Covert, D. Hubbard, J. Jennings, S. Pierce, E. Scholz; Lamont Doherty Earth Observatory: T. Takahashi; Duke University: R. Barber, V. Lance, D. Stube, A. Hilting, M. Hiscock, A. Apprill, C. Van Hilst, ; Virginia Institute of Marine Science: W. Smith, H. Ducklow, L. Delizo, J. Oliver, E. Bailey, J. Peloquin, R. Daniels, J. Bauer; University Of Hawaii: M. Landry, R. Bidigare, S. Brown, N. Cassar, B. Twining, K. Selph, C. Sheridan; NOAA Atlantic Oceanographic and Meteorological Laboratory: R. Wanninkhof, K. Sullivan, C. Neill; University of Miami: F. Millero, X. Zhu, W. Hiscock, V. Koehler, A. Cabrera; University of Calif. Lawrence Berkeley National Laboratory: J. Bishop, T. Wood, C. Guay, P. Lam; Rutgers University: P. Falkowski, Z. Kolber, R. Nicolayson, S. Tozzi, M. Gorbunov, M. Koblizek; University of Massachusets: M. Altabet, M. McIlvan, D. Timothy; New Mexico Tech.: Oliver Wingenter; San Francisco State Univ. - Romberg Tiburon Center: W. Cochlan, J. Herndon; University of Calif. Santa Cruz: R. Kudela, A. Roberts; Univ. of Calif. Santa Barbara: M. Brezinski, J. Jones, M. Demarest; Massachusets Inst. of Technology: S. Chisolm, Z. Johnson; Woods Hole Oceanographic Institute: K. Buesseler, J. Andrews, G. Crossin, S. Pike, J. Tegeder, C. Herbold, K. Mahoney, M.Coggeshell ; University of East Anglia: L. Houghton, L. Goldson, A. Watson, J. Ledwell; Institute of Marine Research, Kiel: Peter Croot; University of Otago: R. Frew, E. Abraham, P. Boyd.

  5. HSPB8 and BAG3 cooperate to promote spatial sequestration of ubiquitinated proteins and coordinate the cellular adaptive response to proteasome insufficiency.

    Science.gov (United States)

    Guilbert, Solenn M; Lambert, Herman; Rodrigue, Marc-Antoine; Fuchs, Margit; Landry, Jacques; Lavoie, Josée N

    2018-02-05

    BCL2-associated athanogene (BAG)-3 is viewed as a platform that would physically and functionally link distinct classes of molecular chaperones of the heat shock protein (HSP) family for the stabilization and clearance of damaged proteins. In this study, we show that HSPB8, a member of the small heat shock protein subfamily, cooperates with BAG3 to coordinate the sequestration of harmful proteins and the cellular adaptive response upon proteasome inhibition. Silencing of HSPB8, like depletion of BAG3, inhibited targeting of ubiquitinated proteins to the juxtanuclear aggresome, a mammalian system of spatial quality control. However, aggresome targeting was restored in BAG3-depleted cells by a mutant BAG3 defective in HSPB8 binding, uncoupling HSPB8 function from its binding to BAG3. Depletion of HSPB8 impaired formation of ubiquitinated microaggregates in an early phase and interfered with accurate modifications of the stress sensor p62/sequestosome (SQSTM)-1. This impairment correlated with decreased coupling of BAG3 to p62/SQSTM1 in response to stress, hindering Kelch-like ECH-associated protein (KEAP)-1 sequestration and stabilization of nuclear factor E2-related factor (Nrf)-2, an important arm of the antioxidant defense. Notably, the myopathy-associated mutation of BAG3 (P209L), which lies within the HSPB8-binding motif, deregulated the association between BAG3 and p62/SQSTM1 and the KEAP1-Nrf2 signaling axis. Together, our findings support a so-far-unrecognized role for the HSPB8-BAG3 connection in mounting of an efficient stress response, which may be involved in BAG3-related human diseases.-Guilbert, S. M., Lambert, H., Rodrigue, M.-A., Fuchs, M., Landry, J., Lavoie, J. N. HSPB8 and BAG3 cooperate to promote spatial sequestration of ubiquitinated proteins and coordinate the cellular adaptive response to proteasome insufficiency.

  6. Three-minute constant rate step test for detecting exertional dyspnea relief after bronchodilation in COPD

    Directory of Open Access Journals (Sweden)

    Borel B

    2016-11-01

    Full Text Available Benoit Borel,1,2 Courtney A Wilkinson-Maitland,3 Alan Hamilton,4 Jean Bourbeau,5 Hélène Perrault,6 Dennis Jensen,3,5,7 François Maltais2 1Laboratoire HAVAE, Université de Limoges, Limoges, France; 2Centre de Recherche, Institut Universitaire de Cardiologie et de Pneumologie de Québec, Université Laval, Québec, 3Clinical Exercise and Respiratory Physiology Laboratory, Department of Kinesiology and Physical Education, McGill University, Montréal, QC, 4Boehringer Ingelheim (Canada Limited, Burlington, ON, 5Respiratory Epidemiology and Clinical Research Unit, Montreal Chest Institute, McGill University Health Center, Montreal, QC, 6Faculty of Health Sciences, University of Ottawa, Ottawa, ON, 7Translational Research in Respiratory Diseases Program, Research Institute of the McGill University Health Centre, Montreal, QC, Canada Background: The aim of this study was to evaluate the responsiveness of the 3-minute constant rate step test (3-MST to detect the relief of exertional dyspnea (respiratory discomfort after acute bronchodilation in COPD patients. Patients and methods: A total of 40 patients with moderate-to-severe COPD (mean forced expiratory volume in 1 second: 45.7 (±14.7, % predicted performed four 3-MSTs at randomly assigned stepping rates of 14, 16, 20 and 24 steps/min after inhalation of nebulized ipratropium bromide (500 µg/salbutamol (2.5 mg and saline placebo, which were randomized to order. Patients rated their intensity of perceived dyspnea at the end of each 3-MST using Borg 0–10 category ratio scale. Results: A total of 37 (92.5%, 36 (90%, 34 (85% and 27 (67.5% patients completed all 3 minutes of exercise at 14, 16, 20 and 24 steps/min under both treatment conditions, respectively. Compared with placebo, ipratropium bromide/salbutamol significantly decreased dyspnea at the end of the third minute of exercise at 14 steps/min (by 0.6±1.0 Borg 0–10 scale units, P<0.01 and 16 steps/min (by 0.7±1.3 Borg 0–10 scale

  7. Automated oxygen titration and weaning with FreeO2 in patients with acute exacerbation of COPD: a pilot randomized trial

    Directory of Open Access Journals (Sweden)

    Lellouche F

    2016-08-01

    Full Text Available François Lellouche,1 Pierre-Alexandre Bouchard,1 Maude Roberge,1 Serge Simard,1,2 Erwan L’Her,1,3 François Maltais,1 Yves Lacasse1 1Research Centre, 2Biostatistics Department, Quebec Heart and Lung Institute, Laval University, 3Emergency Medicine, Hôtel-Dieu de Lévis, Laval University, Quebec City, QC, Canada Introduction: We developed a device (FreeO2 that automatically adjusts the oxygen flow rates based on patients’ needs, in order to limit hyperoxia and hypoxemia and to automatically wean them from oxygen. Objective: The aim of this study was to evaluate the feasibility of using FreeO2 in patients hospitalized in the respiratory ward for an acute exacerbation of COPD. Methods: We conducted a randomized controlled trial comparing FreeO2 vs manual oxygen titration in the respiratory ward of a university hospital. We measured the perception of appropriateness of oxygen titration and monitoring in both groups by nurses and attending physicians using a Likert scale. We evaluated the time in the target range of oxygen saturation (SpO2 as defined for each patient by the attending physician, the time with severe desaturation (SpO2 <85%, and the time with hyperoxia (SpO2 >5% above the target. We also recorded length of stay, intensive care unit admissions, and readmission rate. Fifty patients were randomized (25 patients in both groups; mean age: 72±8 years; mean forced expiratory volume in 1 second: 1.00±0.49 L; and mean initial O2 flow 2.0±1.0 L/min. Results: Nurses and attending physicians felt that oxygen titration and monitoring were equally appropriate with both O2 administration systems. The percentage of time within the SpO2 target was significantly higher with FreeO2, and the time with severe desaturation and hyperoxia was significantly reduced with FreeO2. Time from study inclusion to hospital discharge was 5.8±4.4 days with FreeO2 and 8.4±6.0 days with usual oxygen administration (P=0.051. Conclusion: FreeO2 was deemed as an

  8. Cryptic Plutella species show deep divergence despite the capacity to hybridize.

    Science.gov (United States)

    Perry, Kym D; Baker, Gregory J; Powis, Kevin J; Kent, Joanne K; Ward, Christopher M; Baxter, Simon W

    2018-05-29

    Understanding genomic and phenotypic diversity among cryptic pest taxa has important implications for the management of pests and diseases. The diamondback moth, Plutella xylostella L., has been intensively studied due to its ability to evolve insecticide resistance and status as the world's most destructive pest of brassicaceous crops. The surprise discovery of a cryptic species endemic to Australia, Plutella australiana Landry & Hebert, raised questions regarding the distribution, ecological traits and pest status of the two species, the capacity for gene flow and whether specific management was required. Here, we collected Plutella from wild and cultivated brassicaceous plants from 75 locations throughout Australia and screened 1447 individuals to identify mtDNA lineages and Wolbachia infections. We genotyped genome-wide SNP markers using RADseq in coexisting populations of each species. In addition, we assessed reproductive compatibility in crossing experiments and insecticide susceptibility phenotypes using bioassays. The two Plutella species coexisted on wild brassicas and canola crops, but only 10% of Plutella individuals were P. australiana. This species was not found on commercial Brassica vegetable crops, which are routinely sprayed with insecticides. Bioassays found that P. australiana was 19-306 fold more susceptible to four commonly-used insecticides than P. xylostella. Laboratory crosses revealed that reproductive isolation was incomplete but directionally asymmetric between the species. However, genome-wide nuclear SNPs revealed striking differences in genetic diversity and strong population structure between coexisting wild populations of each species. Nuclear diversity was 1.5-fold higher in P. australiana, yet both species showed limited variation in mtDNA. Infection with a single Wolbachia subgroup B strain was fixed in P. australiana, suggesting that a selective sweep contributed to low mtDNA diversity, while a subgroup A strain infected just 1

  9. Essai de reconstitution de l'histoire géologique et structurale de la Méditerranée centrale Attempt to Reconstruct the Geological Tectonics and Intraplate Deformations

    Directory of Open Access Journals (Sweden)

    Schuster J. -M.

    2006-11-01

    Full Text Available La Méditerranée centrale (mer Ionienne occupe une position charnière entre le craton africain au sud et les chaînes de l'arc alpin au nord. La zone étudiée s'étend globalement de l'escarpement maltais à l'ouest, à l'extrémité orientale de la Crête à l'est. Elle se localise à l'aplomb du secteur profond de la Méditerranée centrale. On y distingue cinq unités structurales majeures : le bassin de Syrte, la plaine abyssale ionienne, le cône de Messine, la ride méditerranéenne et le fossé hellénique. La synthèse des éléments géophysiques et géologiques et des mouvements supposés des plaques africaine et eurasienne permet d'esquisser une reconstitution de l'histoire géologique et structurale de la Méditerranée centrale que l'on peut diviser en trois périodes: Trias-Paléocène, Éocène-Miocène, Plio-Quaternaire. Deux tectoniques y prennent place. L'une, protoméditerranéenne (téthysienne, mésogéenne, créatrice des chaînes périméditerranéennes s'étend tout au long des deux premières périodes (Trias à Miocène. L'autre, méditerranéenne, édificatrice de la Mer Méditerranée couvre la deuxième et la troisième période (Éocène à Quaternaire. The central Mediterranean (lonian Sea forms the uncture between the African croton in the S and the ranges of the Alpine arc in the . The zone examined stretches from the Maltese escarpment in the W ta the eastern M of Crete in the E. It is situated directly on top of the deep sector of the central editerranean. Five major structural units can be distinguished there, i.e. the Syrtis Basin, the lonian abyssal plain, the Messina cone, the Mediterranean ridge and the Hellenic trough. A synthesis of the geophysical and geological elements and of the assumed move-mentsoftheAfrican and Eurasion plates has been used ta sketch out a reconstruction of the geological and structural history of the central Mediterranean which can be divided into three periods : Trias

  10. Biochemical and nutritional studies of lupin (Lupinus jermis) seed cultivated in the Sudan

    International Nuclear Information System (INIS)

    Elamin, Malik El Mubarak Mohamed

    1996-12-01

    Two lupin varieties (Rubatab and Dongola) purchased from the local market were used in this study. Physical properities showed that the weight and volume of cv.Dongola were higher than those of cv.Rubatab while thickness and density of cv.Rubatab were higher than those of cv.Dongola. Moisture content ranged from 4.4 to 5.7%. Fiber content ranged from 8.8 to 10.9% of whole seed and for kernels and testa it ranged from 0.9 to 1.8% and from 45 to 47% respectively. The ash content ranged from 1.3 to 1.9%. Oil content ranged from 9.9 to 10.9% in whole seed (raw, debittered) and in kernels ranged from 11.5 to 12.0% while the testa had very low oil content (0.6-1.1 %). Protein content ranged from 49.4 to 50.4 % for raw whole seed and was 47.1 to 50.4 % for debittered whole seeds. For kernels it ranged from 56 to 59%. The protien content of testa ranged from 5.6 to 9.3%. Carbohydrates content was about 23% for raw whole seed and ranged from 25 to 26% for debittered whole seed. It ranged from 21 to 24% for kernels and increased to 39% in testa. Calorific value for 100 g of whole seed ranged from 381 to 433 kcal. It decreased in testa ranging from 187 to193 kcal. In this study both varieties did not contain antinutritional factors e.g. trypsin inhibitors. The tannins content and phytate was very low presumably due to debittering. Fatty acid composition of lupin seed oil showed that it is composed of ten fatty acids presented by Oleic (52-60%), Linoleic acid (16-19%), Palmatic (10-11%)and palmitoleic, lauric, myristeic, largeric, lenolenic, arrashidic acids. The mineral content of lupin seed showed Ca 0.1%, K 0.4-0.5%. Mg 0.2-0.3%. Zn 107-135 μg/g. Pb 9-10 μg/g. In this study lupin proteins were fractionated by two methods: Mendel-osborne method and landry and moureaux. Protein fractions obtained by the first method were allbumin which ranged from 3.1 to 24.8%, globulin ranged 1.9 to 3%, gluelin raanged from 13.2 to 62% The landry and moureaux method gave globulins in the

  11. Biochemical and nutritional studies of lupin (Lupinus jermis) seed cultivated in the Sudan

    Energy Technology Data Exchange (ETDEWEB)

    Elamin, Malik El Mubarak Mohamed [Department of Biochemistry and Soil Science, Faculty of Agriculture, University of Khartoum, Khartoum (Sudan)

    1996-12-01

    Two lupin varieties (Rubatab and Dongola) purchased from the local market were used in this study. Physical properities showed that the weight and volume of cv.Dongola were higher than those of cv.Rubatab while thickness and density of cv.Rubatab were higher than those of cv.Dongola. Moisture content ranged from 4.4 to 5.7%. Fiber content ranged from 8.8 to 10.9% of whole seed and for kernels and testa it ranged from 0.9 to 1.8% and from 45 to 47% respectively. The ash content ranged from 1.3 to 1.9%. Oil content ranged from 9.9 to 10.9% in whole seed (raw, debittered) and in kernels ranged from 11.5 to 12.0% while the testa had very low oil content (0.6-1.1 %). Protein content ranged from 49.4 to 50.4 % for raw whole seed and was 47.1 to 50.4 % for debittered whole seeds. For kernels it ranged from 56 to 59%. The protien content of testa ranged from 5.6 to 9.3%. Carbohydrates content was about 23% for raw whole seed and ranged from 25 to 26% for debittered whole seed. It ranged from 21 to 24% for kernels and increased to 39% in testa. Calorific value for 100 g of whole seed ranged from 381 to 433 kcal. It decreased in testa ranging from 187 to193 kcal. In this study both varieties did not contain antinutritional factors e.g. trypsin inhibitors. The tannins content and phytate was very low presumably due to debittering. Fatty acid composition of lupin seed oil showed that it is composed of ten fatty acids presented by Oleic (52-60%), Linoleic acid (16-19%), Palmatic (10-11%)and palmitoleic, lauric, myristeic, largeric, lenolenic, arrashidic acids. The mineral content of lupin seed showed Ca 0.1%, K 0.4-0.5%. Mg 0.2-0.3%. Zn 107-135 {mu}g/g. Pb 9-10 {mu}g/g. In this study lupin proteins were fractionated by two methods: Mendel-osborne method and landry and moureaux. Protein fractions obtained by the first method were allbumin which ranged from 3.1 to 24.8%, globulin ranged 1.9 to 3%, gluelin raanged from 13.2 to 62% The landry and moureaux method gave globulins in

  12. Mechanism-based fluorescent labeling of beta-galactosidases. An efficient method in proteomics for glycoside hydrolases.

    Science.gov (United States)

    Kurogochi, Masaki; Nishimura, Shin-Ichiro; Lee, Yuan Chuan

    2004-10-22

    (4-N-5-Dimethylaminonaphthalene-1-sulfonyl-2-difluoromethylphenyl)-beta-d-galactopyranoside was synthesized and successfully tested on beta-galactosidases from Xanthomonas manihotis (Wong-Madden, S. T., and Landry, D. Glycobiology (1995) 5, 19-28 and Taron, C. H., Benner, J. S., Hornstra, L. J., and Guthrie, E. P. (1995) Glycobiology 5, 603-610), Escherichia coli (Jacobson, R. H., Zhang, X. J., DuBose, R. F., and Matthews, B. W. (1994) Nature 369, 761-766), and Bacillus circulans (Fujimoto, H., Miyasato, M., Ito, Y., Sasaki, T., and Ajisaka, K. (1988) Glycoconj. J. 15, 155-160) for the rapid identification of the catalytic site. Reaction of the irreversible inhibitor with enzymes proceeded to afford a fluorescence-labeled protein suitable for further high throughput characterization by using antidansyl antibody and matrix-assisted laser desorption ionization time-of-flight/time-of-flight (MALDI-TOF/TOF). Specific probing by a fluorescent aglycon greatly facilitated identification of the labeled peptide fragments from beta-galactosidases. It was demonstrated by using X. manihotis beta-galactosidase that the Arg-58 residue, which is located within a sequence of 56IPRAYWKD63, was labeled by nucleophilic attack of the guanidinyl group. This sequence including Arg-58 (Leu-46 to Tyr-194) was similar to that (Met-1 to Tyr-151) of Thermus thermophilus A4, which is the first known structure of glycoside hydrolases family 42 (Hidaka, M., Fushinobu, S., Ohtsu, N., Motoshima, H., Matsuzawa, H., Shoun, H., and Wakagi, T. (2002) J. Mol. Biol. 322, 79-91). A catalytic glutamic acid (Glu-537) of E. coli beta-galactosidase was proved to be labeled by the same procedure, suggesting that the modification site with this irreversible substrate might depend both on the nucleophilicity of the amino acids and their spatial arrangement in the individual catalytic cavity. Similarly, a Glu-259 in 257TLEE260 was selectively labeled using B. circulans beta-galactosidase, indicating that Glu

  13. Using the Frailty Assessment for Care Planning Tool (FACT to screen elderly chronic kidney disease patients for frailty: the nurse experience

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    Moffatt H

    2018-05-01

    Full Text Available Heather Moffatt,1 Paige Moorhouse,1,2 Laurie Mallery,1,2 David Landry,1 Karthik Tennankore2 1Nova Scotia Health Authority, Halifax, NS, Canada; 2Dalhousie University, Halifax, NS, CanadaPurpose: Recent evidence supports the prognostic significance of frailty for functional decline and poor health outcomes in patients with chronic kidney disease. Yet, despite the development of clinical tools to screen for frailty, little is known about the experiential impact of screening for frailty in this setting. The Frailty Assessment for Care Planning Tool (FACT evaluates frailty across 4 domains: mobility, function, social circumstances, and cognition. The purpose of this qualitative study was as follows: 1 explore the nurse experience of screening for frailty using the FACT tool in a specialized outpatient renal clinic; 2 determine how, if at all, provider perceptions of frailty changed after implementation of the frailty screening tool; and 3 determine the perceived factors that influence uptake and administration of the FACT screening tool in a specialized clinical setting.Methods: A semi-structured interview of 5 nurses from the Nova Scotia Health Authority, Central Zone Renal Clinic was conducted. A grounded theory approach was used to generate thematic categories and analysis models.Results: Four primary themes emerged in the data analysis: “we were skeptical”, “we made it work”, “we learned how”, and “we understand”. As the renal nurses gained a sense of confidence in their ability to implement the FACT tool, initial barriers to implementation were attenuated. Implementation factors – such as realistic goals, clear guidelines, and ongoing training – were important factors for successful uptake of the frailty screening initiative.Conclusion: Nurse participants reported an overall positive experience using the FACT method to screen for frailty and indicated that their understanding of the multiple dimensions and subtleties of

  14. Ectopic fat accumulation in patients with COPD: an ECLIPSE substudy

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    Martin M

    2017-01-01

    Full Text Available Mickaël Martin,1 Natalie Almeras,1 Jean-Pierre Després,1 Harvey O Coxson,2 George R Washko,3 Isabelle Vivodtzev,4 Emiel FM Wouters,5 Erica Rutten,6 Michelle C Williams,7 John T Murchison,8 William MacNee,7 Don D Sin,2 François Maltais1 On behalf of the Evaluation of COPD Longitudinally to Identify Predictive Surrogate Endpoints (ECLIPSE Study Group 1Research Centre, Institut universitaire de cardiologie et de pneumologie de Québec, Université Laval, Québec, QC, 2Department of Radiology, University of British Columbia, Vancouver, BC, Canada; 3Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USA; 4Hypoxia Pathophysiology Laboratory, Grenoble University Hospital, Grenoble, France; 5Department of Respiratory Medicine, Maastricht University Medical Center, Maastricht, 6Research and Development, CIRO, Horn, the Netherlands; 7Department of Respiratory Medicine, University of Edinburgh, 8Department of Radiology, Royal Infirmary of Edinburgh, Edinburgh, UK Background: Obesity is increasingly associated with COPD, but little is known about the prevalence of ectopic fat accumulation in COPD and whether this can possibly be associated with poor clinical outcomes and comorbidities. The Evaluation of COPD Longitudinally to Identify Predictive Surrogate Endpoints (ECLIPSE substudy tested the hypothesis that COPD is associated with increased ectopic fat accumulation and that this would be associated with COPD-related outcomes and comorbidities.Methods: Computed tomography (CT images of the thorax obtained in ECLIPSE were used to quantify ectopic fat accumulation at L2–L3 (eg, cross-sectional area [CSA] of visceral adipose tissue [VAT] and muscle tissue [MT] attenuation, a reflection of muscle fat infiltration and CSA of MT. A dose–response relationship between CSA of VAT, MT attenuation and CSA of MT and COPD-related outcomes (6-minute walking distance [6MWD], exacerbation rate, quality of life, and forced

  15. A study of the safety and efficacy of travoprost 0.004%/timolol 0.5% ophthalmic solution compared to latanoprost 0.005% and timolol 0.5% dosed concomitantly in patients with open-angle glaucoma or ocular hypertension

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    Douglas J Rhee

    2008-06-01

    Full Text Available Douglas J Rhee1, James H Peace2, Sushanta Mallick3, Theresa A Landry3, Michael VW Bergamini3, and the Study Group*1Massachusetts Eye and Ear Infirmary, Harvard University, Boston, MA, USA; 2Diabetic Eye Medical Clinic, Inglewood, CA, USA; 3Alcon Laboratories, Inc., Ft. Worth, TX, USA; *Study Group members listed in AppendixBackground/Aims: To compare the intraocular pressure (IOP-lowering efficacy of travoprost 0.004%/timolol 0.5% in fixed combination with the unfixed combination of latanoprost 0.005% and timolol 0.5% in open-angle glaucoma or ocular hypertension patients with IOP levels below 18 mmHg on the unfixed combination of latanoprost 0.005% and timolol 0.5%.Methods: Following a 30-day open-label run-in with latanoprost QD PM and timolol QD AM, subjects with intraocular pressure below 18 mmHg were randomized to continue concomitant latanoprost QD PM and timolol QD AM or switch to travoprost 0.004%/timolol 0.5% QD AM and vehicle QD PM in masked fashion and were followed for 3 months. The primary efficacy endpoint was mean IOP reduction from baseline.Results: There were no clinically relevant or statistically significant differences in mean IOP, mean IOP change from baseline, or percentage IOP change from baseline between the two treatment groups. Between-group differences in mean IOP were within ±0.3 mmHg at all time points (p ≥ 0.384, and between-group differences in mean IOP change from baseline were within ±0.4 mmHg at all time points. Overall, 88% of patients whose IOP was less than 18 mmHg on the unfixed combination of latanoprost and timolol remained well controlled on the same regimen in the masked portion of the study, compared with 92% who remained well controlled after switching to travoprost/timolol.Conclusion: Travoprost 0.004%/timolol 0.5% administered once daily and concomitant administration of timolol 0.5% and latanoprost 0.005% produce similar maintenance of IOP-lowering effect in patients who were previously well

  16. Carbon isotope fractionation during diamond growth in depleted peridotite: Counterintuitive insights from modelling water-maximum CHO fluids as multi-component systems

    Science.gov (United States)

    Stachel, T.; Chacko, T.; Luth, R. W.

    2017-09-01

    relatively reduced and had methane as the dominant carbon species (XCO2 = 0.1-0.5). Application of our model to a recently published set of in-situ carbon isotope analyses for peridotitic diamonds from Marange, Zimbabwe (Smit et al., 2016), which contain CH4 fluid inclusions, allows us to perfectly match the observed co-variations in δ13 C, δ15 N and N content and at the same time explain the previously counter-intuitive observation of progressive 13C enrichment in diamonds that appear to have grown from a fluid with methane as the dominant carbon species. Similarly, the almost complete absence in the published record of progressive 13C depletion trends within diamonds likely reflects ubiquitous precipitation from CH4- and CO2-bearing water-rich fluids, rather than diamond formation exclusively by carbonate-bearing and CH4-free oxidized fluids or melts.

  17. Diagnosis, Prevalence, Awareness, Treatment, Prevention, and Control of Hypertension in Cameroon: Protocol for a Systematic Review and Meta-Analysis of Clinic-Based and Community-Based Studies.

    Science.gov (United States)

    Kuate Defo, Barthelemy; Mbanya, Jean Claude; Tardif, Jean-Claude; Ekundayo, Olugbemiga; Perreault, Sylvie; Potvin, Louise; Cote, Robert; Kengne, Andre Pascal; Choukem, Simeon Pierre; Assah, Felix; Kingue, Samuel; Richard, Lucie; Pongou, Roland; Frohlich, Katherine; Saji, Jude; Fournier, Pierre; Sobngwi, Eugene; Ridde, Valery; Dubé, Marie-Pierre; De Denus, Simon; Mbacham, Wilfred; Lafrance, Jean-Philippe; Nsagha, Dickson Shey; Mampuya, Warner; Dzudie, Anastase; Cloutier, Lyne; Zarowsky, Christina; Tanya, Agatha; Ndom, Paul; Hatem, Marie; Rey, Evelyne; Roy, Louise; Borgès Da Silva, Roxane; Dagenais, Christian; Todem, David; Weladji, Robert; Mbanya, Dora; Emami, Elham; Njoumemi, Zakariaou; Monnais, Laurence; Dubois, Carl-Ardy

    2017-05-29

    independently search, screen, extract data, and assess the quality of selected studies using suitable tools. Selected studies will be analyzed by narrative synthesis, meta-analysis, or both, depending on the nature of the data retrieved in line with the review objectives. This review is part of an ongoing research program on disease prevention and control in the context of the dual burden of communicable and noncommunicable diseases in Africa. The first results are expected in 2017. This review will provide a comprehensive assessment of the burden of hypertension and control measures that have been designed and implemented in Cameroon. Findings will form the knowledge base relevant to stakeholders across the health system and researchers who are involved in hypertension prevention and control in the community and clinic settings in Cameroon, as a yardstick for similar African countries. PROSPERO registration number: CRD42017054950; http://www.crd.york.ac.uk/PROSPERO/ display_record.asp?ID=CRD42017054950 (Archived by WebCite at http://www.webcitation.org/6qYSjt9Jc). ©Barthelemy Kuate Defo, Jean Claude Mbanya, Jean-Claude Tardif, Olugbemiga Ekundayo, Sylvie Perreault, Louise Potvin, Robert Cote, Andre Pascal Kengne, Simeon Pierre Choukem, Felix Assah, Samuel Kingue, Lucie Richard, Roland Pongou, Katherine Frohlich, Jude Saji, Pierre Fournier, Eugene Sobngwi, Valery Ridde, Marie-Pierre Dubé, Simon De Denus, Wilfred Mbacham, Jean-Philippe Lafrance, Dickson Shey Nsagha, Warner Mampuya, Anastase Dzudie, Lyne Cloutier, Christina Zarowsky, Agatha Tanya, Paul Ndom, Marie Hatem, Evelyne Rey, Louise Roy, Roxane Borgès Da Silva, Christian Dagenais, David Todem, Robert Weladji, Dora Mbanya, Elham Emami, Zakariaou Njoumemi, Laurence Monnais, Carl-Ardy Dubois. Originally published in JMIR Research Protocols (http://www.researchprotocols.org), 29.05.2017.

  18. Clinical outcomes with olanzapine long-acting injection: impact of the 3-hour observation period on patient satisfaction and well-being

    Directory of Open Access Journals (Sweden)

    Anand E

    2016-10-01

    Full Text Available Ernie Anand,1 Lovisa Berggren,2 John Landry,3 Ágoston Tóth,4 Holland C Detke5 1Neuroscience Medical Affairs, Eli Lilly & Company Ltd, Windlesham, UK; 2Global Statistical Sciences, Lilly Deutschland GmbH, Bad Homburg, Germany; 3Global Statistical Sciences, Eli Lilly Canada Inc., Toronto, ON, Canada; 4Neuroscience, Lilly Hungary, Budapest, Hungary; 5Psychiatry and Pain Disorders, Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN, USA Background: The objective of the present analysis is to determine the impact of the 3-hour observation period for olanzapine long-acting injection (LAI on patient satisfaction and well-being by comparing data collected before and after its implementation. Methods: This is a post hoc analysis of patients treated with olanzapine LAI in 1 a 6-month fixed-dose randomized controlled trial and/or 2 a 6-year open-label safety study. This analysis was limited to patients with schizophrenia who were treated with olanzapine LAI consistent with the approved indication and dosing recommendations of the European Union Summary of Product Characteristics (N=966. Of the 966 patients, the analysis further focused only on those patients who received both 1 at least one injection before the implementation of the 3-hour observation period and 2 at least one injection after implementation of the 3-hour observation period (N=487. Patient satisfaction was assessed with the three-item Patient Satisfaction with Medication Questionnaire-Modified. Responses were averaged across all postbaseline visits occurring before (ie, without the implementation of the 3-hour observation period and across all postbaseline visits occurring after (ie, with the implementation of the 3-hour observation period. In addition, the rate of postinjection delirium/sedation syndrome events was calculated. Results: There was no meaningful change after implementation of the 3-hour observation period in satisfaction (before: mean [SD] =4.0 [1.02] and

  19. Large scale atomistic approaches to thermal transport and phonon scattering in nanostructured materials

    Science.gov (United States)

    Savic, Ivana

    2012-02-01

    ] [3] R. Venkatasubramanian, E. Siivola, T. Colpitts, and B. O'Quinn, Nature 413, 597 (2001).[0pt] [4] B. Poudel et al, Science 320, 634 (2008).[0pt] [5] See e.g. Y. He, D. Donadio, and G. Galli, Nano Lett. 11, 3608 (2011).[0pt] [6] See e.g. A. Ward and D. A. Broido, Phys. Rev. B 81, 085205 (2010).[0pt] [7] See e.g. I. Savic, N. Mingo, and D. A. Stewart, Phys. Rev. Lett. 101, 165502 (2008).[0pt] [8] I. Savic, D.Donadio, F.Gygi, and G.Galli (in preparation).[0pt] [9] See e.g. J. E. Turney, E. S. Landry, A. J. H. McGaughey, and C. H. Amon, Phys. Rev. B, 79, 064301 (2009).

  20. LC-MSdetermination of L-DOPA concentration in the leaf and flower tissues of six faba bean (Vicia fabaL. lines with common and rare flowercolors

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    Jinguo Hu

    2015-07-01

    as a natural source of this medicinally important molecule. When developing faba bean as a functional food crop for PD patients, a careful selection of genotype seems necessary for exploiting the full potential of this natural remedy. Conclusion: Consumption of young pods and leaves is the most practical means for direct intake or processing of L-DOPA. Lastly, favorable environmental conditions for growth will optimize L-DOPA yield (Landry, et al., 2015. Further analysis of the genetic control of L-DOPA synthesis and metabolism will be valuable, with the possibility of developing environmentally resilient cultivars that can produce desirable amounts of L-DOPA for pharmaceutical use.

  1. Benchmarking the Sandbox: Quantitative Comparisons of Numerical and Analogue Models of Brittle Wedge Dynamics (Invited)

    Science.gov (United States)

    Buiter, S.; Schreurs, G.; Geomod2008 Team

    2010-12-01

    , we find differences in shear zone dip angle and surface slope between numerical and analogue models and, in 3D experiments, along-strike variations of structures in map view. Our experiments point out that we need careful treatment of material properties, discontinuities in boundary conditions, model building techniques, and boundary friction for sandbox-like setups. We show that to first order we successfully simulate sandbox-style brittle behavior using different numerical modeling techniques and that we can obtain similar styles of deformation behavior in numerical and laboratory experiments at similar levels of variability. * The GeoMod2008 Team: M. Albertz, C. Beaumont, C. Burberry, J.-P. Callot, C. Cavozzi, M. Cerca, J.-H. Chen, E. Cristallini, A. Cruden, L. Cruz, M. Cooke, T. Crook, J.-M. Daniel, D. Egholm, S. Ellis, T. Gerya, L. Hodkinson, F. Hofmann, V Garcia, C. Gomes, C. Grall, Y. Guillot, C. Guzmán, T. Nur Hidayah, G. Hilley, B. Kaus, M. Klinkmüller, H. Koyi, W. Landry, C.-Y. Lu, J. Macauley, B. Maillot, C. Meriaux, Y. Mishin, F. Nilfouroushan, C.-C. Pan, C. Pascal, D. Pillot, R. Portillo, M.Rosenau, W. Schellart, R. Schlische, P. Souloumiac, A. Take, B. Vendeville, M. Vettori, M. Vergnaud, S.-H. Wang, M. Withjack, D. Yagupsky, Y. Yamada

  2. Conceptualizing Interprofessional Teams as Multi-Team Systems-Implications for Assessment and Training.

    Science.gov (United States)

    West, Courtney; Landry, Karen; Graham, Anna; Graham, Lori; Cianciolo, Anna T; Kalet, Adina; Rosen, Michael; Sherman, Deborah Witt

    2015-01-01

    SGEA 2015 CONFERENCE ABSTRACT (EDITED). Evaluating Interprofessional Teamwork During a Large-Scale Simulation. Courtney West, Karen Landry, Anna Graham, and Lori Graham. CONSTRUCT: This study investigated the multidimensional measurement of interprofessional (IPE) teamwork as part of large-scale simulation training. Healthcare team function has a direct impact on patient safety and quality of care. However, IPE team training has not been the norm. Recognizing the importance of developing team-based collaborative care, our College of Nursing implemented an IPE simulation activity called Disaster Day and invited other professions to participate. The exercise consists of two sessions: one in the morning and another in the afternoon. The disaster scenario is announced just prior to each session, which consists of team building, a 90-minute simulation, and debriefing. Approximately 300 Nursing, Medicine, Pharmacy, Emergency Medical Technicians, and Radiology students and over 500 standardized and volunteer patients participated in the Disaster Day event. To improve student learning outcomes, we created 3 competency-based instruments to evaluate collaborative practice in multidimensional fashion during this exercise. A 20-item IPE Team Observation Instrument designed to assess interprofessional team's attainment of Interprofessional Education Collaborative (IPEC) competencies was completed by 20 faculty and staff observing the Disaster Day simulation. One hundred sixty-six standardized patients completed a 10-item Standardized Patient IPE Team Evaluation Instrument developed from the IPEC competencies and adapted items from the 2014 Henry et al. PIVOT Questionnaire. This instrument assessed the standardized or volunteer patient's perception of the team's collaborative performance. A 29-item IPE Team's Perception of Collaborative Care Questionnaire, also created from the IPEC competencies and divided into 5 categories of Values/Ethics, Roles and Responsibilities

  3. L'Escarpement de Malte, le mont Alfeo et les monts de Médine: marges anciennes du bassin Ionien (synthèse des données des campagnes a la mer Escarmed Malta Escarpment, Alfeo and Medina Seamounts: Former Margins of the Ionian Basin

    Directory of Open Access Journals (Sweden)

    Groupe Escarmed

    2006-11-01

    Full Text Available Le Comité d'Etudes Pétrolières Marines (CEPM et le Centre National pour l'Exploitation des Océans (CNEXO ont mené une série d'études sous-marines des escarpements ioniens pour en définir l'origine, l'âge et l'évolution. Les résultats présentés ici concernent l'escarpement de Malte, le mont Alfeo et les monts de Médine à l'ouest et au sud-ouest du bassin Ionien profond. Ils comprennent les données bathymétriques sous forme d'une carte à 1/100 000 hors texte, l'analyse morphologique des reliefs, les déterminations stratigraphiques effectuées sur les échantillons récoltés en dragages, carottages ou en plongées, l'analyse structurale à partir de profils de sismique réflexion et des plongées, et l'étude de la subsidence depuis le Trias supérieur à partir des forages réels du plateau maltais et des forages fictifs du rebord de l'escarpement de Malte. Les conclusions font ressortir : - l'existence de séries carbonatées de plate-forme d'âge Jurassique inférieur pour l'escarpement de Malte et le mont Alfeo, et Crétacé inférieur pour les monts de Médine; - un changement paléogéographique majeur : à partir du Jurassique supérieur pour l'escarpement de Malte et à partir de l'Albien pour ceux de Médine; - l'existence de séries condensées à dater de ce changement paléogéographique et d'une érosion constante jusqu'à l'Actuel, érosion dont les processus variés ont de nombreuses conséquences sur la sédimentation de tels reliefs; - quatre phases de subsidence essentielles : Jurassique moyen, limite Crétacé inférieur-Crétacé supérieur, Miocène inférieur et moyen, Plio-Quaternaire. La parenté du mont Alfeo avec l'escarpement de Malte a été bien reconnue, par contre, les monts de Médine ne semblent se rattacher à leur histoire qu'à partir du Crétacé supérieur et ont sans doute une évolution comparable au plateau cyrénien. Ces escarpements, comme les autres escarpements ioniens, doivent leurs

  4. A case of Guillain — Barre syndrome associated with ixodes tick borreliosis and listeriosis

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    O.N. Domashenko

    2017-03-01

    , colorless, contains protein 0.71g/l, cytosis makes 1 cell per mcl (lymphocyte, red cell count was 1–3 per mcl, positive Pandy’s test, and glucose ratio of 3.9 mmol/l. IIFT (IgM, liquor as of 07.11.2016 indentified: negative Rubella virus; measles, mumps, Varicella zoster virus, adenovirus type 3; EBV, capsid antigen; Treponema pallidum; Toxoplasma gondii; HSV type I; negative HSV type II; Coxsackie virus type B1; Coxsackie virus type А7; Echo virus type 7; positive Borrelia afzelii; Borrelia burgdorferi sensu stricto; Borrelia garinii; Listeria monocytogenes 1/2а; Listeria monocytogenes 4b; СМV; negative Hemophilus influenza. PCR (liquor as of 07.11.2016 showed: no Toxoplasma gondii, Human herpes virus type 6, СМV. IgM antibodies profile to Borrelia antigens in the immunoblotting reaction (blood as of 09.11.2016 revealed specific antibodies of IgM class to Borrelia garinii (Flagellin, OspC; OspC to Borrelia afzelii — negative; OspC to Borrelia burgdorferi — negative. There was diagnosed Guillain — Barre acute inflammatory-allergic polyneuropathy (Landry type with pronounced quadriparesis, bulbar syndrome, oculomotor dysfunctions, associated with ixodes tick borreliosis and listeriosis, which were confirmed by IgM revealed to Borrelia garinii (IIFT in the liquor and Western blot reaction in the blood, IgM to Listeria monocytogenes 1/2а, 4b (IIFT in the liquor. The therapy included immunovenin, 5 sessions of plasmapheresis, cefepime, retarpen, cytoflavinum, cycloferonum, ceraxon, actovegin, neuromidin, proserinum, combilipen, diclophenacum, nucleo CMP, mexidol, fluconazole, probiotics, glucose solution, panangin, insulin, L-lysine aescinat, berlithion, suprastin, lasix, berlipril, bisoprololum, tube feeding, APV, microclysters. Since the 48th day of the disease the state of the patient started improving and the rapid recovery of neurological status was observed. Independent breathing restored. The laryngeal-pharyngeal reflexes, sensitive and motor activity

  5. Book Review: Backhaus, Peter (2007: Linguistic Landscapes: A Comparative Study of Urban Multilingualism in Tokyo. Clevedon: Multilingual Matters; 158 Pages ISBN 9781853599460

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    Omar Alomoush

    2015-12-01

    , arguing that the examination of multilingualism on signs in the public space differs from other modes of communication in written and spoken contexts. In addition, the writer discusses different definitions and interpretations of the term linguistic landscape and senses and types of the term ‘sign’.  After Itagi and Singh (2002, the author (p.10 draws a distinction between the noun ‘linguistic landscape’ and the gerund ‘linguistic landscaping’. While the former refers to ‘the planning and implementation of actions pertaining to language on signs’, the latter relates to ‘the result of these actions’. Throughout his monograph, Backhaus maintains a distinction between these two terms as cited above. As maintained by Backhaus (p.12, only the paper introduced by Landry and Bourhis (1997 established this field of study as a coherent discipline, even though several previous studies employed linguistic landscape research. This is mainly apparent in Backhaus’s expansion upon the definition of survey items suggested by Landry and Bourhis (1997.   In chapter three, Previous Approaches to the Linguistic Landscape: An Overview, Backhaus gives a comprehensive overview of previous linguistic landscape studies conducted in different urban settings, including Brussels (Tulp, 1978, Montreal (Monnier, 1989, Paris and Dakar (Calvet, 1990,1994, and Lira, a town in Uganda  (Reh, 2004. In light of these studies, the author notices that the language policy of the state does not indicate which code(s prevail(s in the public space, whose language(s is /are mainly manifested in language practices on nonofficial signs.. The author also discusses the methodological issues followed in the above studies to arrive at a congruent methodological framework aiming at examining multilingualism from a sociolinguistic point of view. In the light of the methodology followed in the abovementioned studies, Chapter four outlines the main concerns that envelope the sociolinguistics of the

  6. Level II scour analysis for Bridge 24 (MANCUS00070024) on U.S. Route 7, crossing Lye Brook, Manchester, Vermont

    Science.gov (United States)

    Olson, Scott A.

    1997-01-01

    28, 1995). The bridge is supported by vertical, concrete abutments with wingwalls. The channel is skewed approximately 45 degrees to the opening while the opening-skew-to-roadway is 55 degrees. At the time of construction, the downstream channel was relocated (written communication, Dan Landry, VTAOT, January 2, 1997). A levee on the downstream right bank was also constructed and is protected by type-4 stone-fill (less than 60 inches diameter) extending from the bridge to more than 300 feet downstream. Type-2 stone fill (less than 36 inches diameter) covers the downstream right bank from the bridge to more than 300 feet downstream. Type-2 stone-fill also extends from the bridge to 220 feet upstream on both upstream banks. Additional details describing conditions at the site are included in the Level II Summary and Appendices D and E. Scour depths and recommended rock rip-rap sizes were computed using the general guidelines described in Hydraulic Engineering Circular 18 (Richardson and others, 1995) for the 100- and 500-year discharges. In addition, the incipient roadway-overtopping discharge is analyzed since it has the potential of being the worst-case scour scenario. Total scour at a highway crossing is comprised of three components: 1) long-term streambed degradation; 2) contraction scour (due to accelerated flow caused by a reduction in flow area at a bridge) and; 3) local scour (caused by accelerated flow around piers and abutments). Total scour is the sum of the three components. Equations are available to compute depths for contraction and local scour and a summary of the results of these computations follows. Contraction scour for all modelled flows ranged from 1.0 to 1.6 ft. The worst-case contraction scour occurred at the 500-year discharge. Abutment scour computations for the left abutment ranged from 14.5 to 16.1 ft. with the worst-case occurring at the 100-year discharge. Abutment scour computations for the right abutment ranged from 6.9 to 10.4 ft. with

  7. Declarative memory in abused and neglected infants.

    Science.gov (United States)

    Cheatham, Carol L; Larkina, Marina; Bauer, Patricia J; Toth, Sheree L; Cicchetti, Dante

    2010-01-01

    's imitative behaviors. Thus, it would appear that maternal negative feedback to child-initiated behaviors is related to an increase in imitative behaviors that are most likely met with positive reinforcement. The continued pursuit of this positivity may impede the development of self-initiated behaviors; delayed development of self-initiated behavior has been linked to disorders of social competence (Landry, Smith, Miller-Loncar, & Swank, 1998). However, imitation has long been known to be a mechanism of learning (Piaget, 1962) and has become an accepted tool for assessment of declarative memory (Bauer, 2004). Whereas the adaptation to abuse posited by Valentino et al. (2006) may be detrimental to social development, our data for this same sample indicate that the reliance on imitative behavior exhibited by the abused children may afford them an advantage at 21 months of age in imitation paradigms. The neglected children are thus at a disadvantage relative to the abused children in the study reported here in that they were not reinforced by mothers for imitative behavior. It is important to note that all children in this sample were from low-income homes. Scores on these events for both target actions and ordered pairs are higher in samples of higher SES children (e.g., Bauer et al., 2000). Thus, the low SES of the families affected performance across the groups. It is possible that the factor responsible for the difference between the abused group and the neglected group is resilience in the face of poverty. Resilience is the ability to recover following a traumatic event or adversity (Masten, 2001), and has been related to child characteristics, such as general intelligence (Masten et al., 1988). It has been proposed that neural plasticity may be responsible for this recovery (Cicchetti & Curtis, 2006). Alternatively, as has been detailed earlier in this chapter, the advantage afforded abused children could arise from the strengthening of neural pathways. It would be

  8. Présentation

    Directory of Open Access Journals (Sweden)

    Gregor Perko

    2011-12-01

    Full Text Available Au cours des dernières décennies où l’on assiste à une refondation de la morphologie, la discipline s’intéresse de plus en plus à des phénomènes « périphériques », « marginaux », « irréguliers » ou « extragrammaticaux », à des phénomènes n’appartenant pas aux « régions nodales » de la morphologie. Le présent numéro de Linguistica, premier numéro thématique de notre revue, réunit des études qui s’intéres- sent aux frontières internes et externes de la morphologie. La diversité et la richesse des thèmes abordés et des approches proposées témoignent d’un intérêt croissant que les linguistes, non pas uniquement les morphologues, portent à cette thématique. Les articles proposés s’articulent autour de cinq axes majeurs. Un premier axe rassemble les articles qui étudient les frontières entre différentes composantes de la morphologie. L’étude de Michel Roché examine les contraintes lexicales et morphophonologiques sur le paradigme des dérivés en –aie. Les résultats de son analyse remettent en question la notion de « règle de construction des lexèmes ». Irena Stramljič Breznik et Ines Voršič se penchent sur les néologismes de sport en slovène et essaient d’évaluer la productivité ou la créativité des procédés morphologiques en jeu. Dans une étude d’inspiration cognitiviste, Alexandra Bagasheva aborde l’hétérogénéité des verbes composés en anglais. En s’appuyant sur les données fournies par les para- digmes verbaux du maltais, Maris Camilleri examine la complexité du phénomène de classes flexionnelles basées sur les radicaux. Trois travaux concernent des procédés typiquement « extragrammaticaux » servant à former le plus souvent des occasionnalismes: Arnaud Léturgie tente de dégager des propriétés prototypiques de l’amalgamation lexicale en français, notamment celles de la création des mots-valises; Silvia Cacchiani analyse, à l

  9. Exploring the learning context in shifts between online and offline learning

    Directory of Open Access Journals (Sweden)

    Karen Borgnakke

    2015-11-01

    Together: Designing Participatory Research in Online Ethnography Paolo Landri, Andrea Maccarini, Rosanna De Rosa (EdsCNR-IRPPS e-publishing http://www.irpps.cnr.it/e-pub/ojs/index.php/mono/article/view/978-88-98822-02-7.Copenhagen 2014:Rethinking Educational Ethnography: Researching on-line communities and interactionshttp://pur.mef.ku.dk/itaka/konferencer/ree/Karen Borgnakke professor, Department of Media, Cognition and Communication, karenb@hum.ku.dkFaculty of HumanitiesUniversity of CopenhagenKaren Blixens Vej 4DK-2300 København S

  10. Corticotrofina e cortiomdes em neurologia: avaliação critica dos resultados em 518 pacientes hospitalizados Corticotropin and corticosteroids in Neurology: critical evaluation of the results in 518 patients

    Directory of Open Access Journals (Sweden)

    J. Lamartine de Assis

    1968-12-01

    emprego. Em certos casos de evolução dramática o uso do ACTH e/ou corticóides torna-se quase imperativo.Based on the treatment with corticotrofin and corticosteroids of 518 patients admited at the "Clínica Neurológica do Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo", in the period of 1952 to 1967, the authors performed a critical evaluation of the results obtained in several diseases of the nervous system: demyelinating diseases, polyradiculitis (Landry-Guillain-Barré syndrome, Sydenham's chorea, sabacute combined degeneration, hypsarrhytmia, myasthenia gravis, polymiositis, tuberculous meningitis and neurocysticercosis. ACTH or corticotrofin were employed intravenously or intramuscularly and the steroids were given orally or parenterally. The results with adrenal steroids or ACTH treatment were analysed under the treatment and preventive aspects. Concerning this aspect the analysis hás been limited, to tuberculous meningitis and neurocistycercosis cases. The evaluation of the therapeutic effects was based on clinical criterion and, when necessary, has been subordinated to an evolutive study concerning complementary examinations. Only immediate results based on general conditions of the patients at hospitalar discharge were reported. The authors conclude: 1. The corticotrofin and/or corticosteroids are used with favorable results in the treatment of several nervous system diseases as a therapeutic method as well as prophylactically. 2. Generally the results are difficult to evaluate and some times they depend on the nature and evolution of the disease and also on the period in which the treatment was established. 3. Regarding the therapeutic methods, the acute immunoallergic diseases or neuropathies with cyclical evolution those with a tendency to a progressive worsening and those with paroxystic manifestations responded in a better way to hormonal therapy. Some diseases which use to have an evolution with exacerbations and whose