Full Text Available R.ox.an.e is an embedded system for search and rescue of trapped victims in the ruins of an earthquake. A rescue team coulduse such kind of digital assistants in order to have quick and safe information about the disaster. The proposed system is asmall size vehicle, with microcontroller based hardware and is wirelessly controlled. The operator has full control of thevehicle and is able to capture real time image of the accident place and various sensors measurements.
Smit, Karen V.; Shirey, Steven B.; Stern, Richard A.; Steele, Andrew; Wang, Wuyi
Mixed-habit (octahedral+ cuboid) diamonds from the Marange alluvial deposits in the eastern Zimbabwe craton have high nitrogen and hydrogen contents that provide an opportunity to evaluate diamond growth mechanisms and C-N-H-O bearing fluids in the lithospheric keel. Light grey cuboid sectors with hydrogen-containing defects trap abundant dispersed CH4 inclusions (Raman peaks at 2917 cm-1) associated with graphite (Raman peaks at 1580 cm-1). Clear octahedral sectors are richer in nitrogen and free of any such inclusions. Core to rim co-variations of δ13C-δ15N and N content can be explained by a mixing trend between earlier fluids that are CH4-rich and later fluids that are more CO3- or CO2-rich. Marange diamonds have limited overall δ13C variation, but do show fractionation during growth towards higher δ13C values. This trend can be explained by diamond precipitation from mixed CH4 and CO2 fluids, where isotopic fractionation occurs as the amount of fluid wanes. Calculated δ15N values for diamond source fluids evolving in this manner are between + 2.3 and + 6.4‰. These N isotopic compositions require CH4-rich and CO3-/CO2-rich 'end-member' fluids to have a recycled metasedimentary component perhaps introduced with subduction of eclogite.
Watt, Robert Gregory [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)
The Ranchero Magnetic Flux Compression Generator (FCG) has been used to create current pulses in the 10-100 MA range for driving both “static” low inductance (0.5 nH) loads1 for generator demonstration purposes and high inductance (10-20 nH) imploding liner loads2 for ultimate use in physics experiments at very high energy density. Simulations of the standard Ranchero generator have recently shown that it had a design issue that could lead to flux trapping in the generator, and a non- robust predictability in its use in high energy density experiments. A re-examination of the design concept for the standard Ranchero generator, prompted by the possible appearance of an aneurism at the output glide plane, has led to a new generation of Ranchero generators designated the RancheroS (for swooped). This generator has removed the problematic output glide plane and replaced it with a region of constantly increasing diameter in the output end of the FCG cavity in which the armature is driven outward under the influence of an additional HE load not present in the original Ranchero. The resultant RancheroS generator, to be tested in LA43S-L13, probably in early FY17, has a significantly increased initial inductance and may be able to drive a somewhat higher load inductance than the standard Ranchero. This report will use the Eulerian AMR code Roxane to study the ability of the new design to drive static loads, with a goal of providing a database corresponding to the load inductances for which the generator might be used and the anticipated peak currents such loads might produce in physics experiments. Such a database, combined with a simple analytic model of an ideal generator, where d(LI)/dt = 0, and supplemented by earlier estimates of losses in actual use of the standard Ranchero, scaled to estimate the increase in losses due to the longer current carrying perimeter in the RancheroS, can then be used to bound the expectations for the current drive one may
A Study of Students' Metalinguistic Competence and Its Probable Effect in the ... Poverty and Governance in Zimbabwean Popular Music · EMAIL FULL TEXT ... Staging Sacrifice: Performing History, Memory, and Ancestral Culture in Four ...
Watt, Robert Gregory [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)
The Ranchero Magnetic Flux Compression Generator (FCG) has been used to create current pulses in the 10-100 MA range for driving both “static” low inductance (0.5 nH) loads1 for generator demonstration purposes and high inductance (10-20 nH) imploding liner loads for ultimate use in physics experiments at very high energy density. This report offers a description of these efforts.
and subsequent generations of immigrants. Roxane Silberman and Richard Alba write that France’s poor record of integration is actually segmented...market compared other immigrants, mainly those who are white.10 Silberman and Alba also conclude that discrimination is rampant at the entry level...Wages, 3. 9 OECD, Jobs, 114–115. 10 Roxane Silberman and Richard Alba, "Segmented Assimilation in France?: Discrimination in the Labor Market
The discovery of diamonds coupled with undesirable characteristics of political institutions cast doubts of a natural resource-led growth in Zimbabwe. I used the discovery of diamonds in Marange to provide evidence of waste and corruption of mineral wealth by political elites. I build on Mehlum et al (2006) rent seeking model to capture the active role played by powerful agents in the domestic political economy in rent seeking activities. I introduce a new assumption into the model that restr...
Full Text Available virus (strain Philips Roxane) ... 44 6.2 1 ( M24001 ) Mink enteritis virus antigenic type 2 capsid protei...... 44 6.2 1 ( M10824 ) Feline panleukopenia virus structural protein genes... 44 6.2 1 ( D00765 ) Mink enteritis... virus strain Abashiri genes for NS a... 44 6.2 1 ( AY665657 ) Mink enteritis ...virus isolate Rodniki-Biocentr cap... 44 6.2 1 ( AY665656 ) Mink enteritis virus isolate Beregovoj-Biocentr
Hongtao Kang; Dafei Liu; Jin Tian; Xiaoliang Hu; Xiaozhan Zhang; Hang Yin; Hongxia Wu; Chunguo Liu; Dongchun Guo; Zhijie Li; Qian Jiang; Jiasen Liu; Liandong Qu
Feline panleucopenia virus (FPV) is a highly infectious pathogen that causes severe diseases in pets, economically important animals and wildlife in China. Although FPV was identified several years ago, little is known about how it overcomes the host innate immunity. In the present study, we demonstrated that infection with the FPV strain Philips-Roxane failed to activate the interferon β (IFN-β) pathway but could antagonize the induction of IFN stimulated by Sendai virus (SeV) in F81 cells. ...
Mohamad, Masitah; Razak, Shamsul Bahri Abd; Salim, Jamilah Mohd.; Ismail, Salwani
A histological and anatomical comparative analysis of Gelam, Melaleuca cajuputi Powell was conducted to determine the adaptability Gelam (Melaleuca cajuputi Powell, Family = Myrtaceae) in two different micro-ecosystems of Terengganu. The sites sampling chosen were Jambu Bongkok Amenity Forest (Formerly known as Rantau Abang Amenity Forest), a large swamp forests and prominent flooding site in the District of Marang, Terengganu and Taman Penyelidikan Alam, Bukit Kor - a hard top soil area of Marang, Terengganu. The objective of this study is to compare the anatomy and histology features of gelam in these two areas. Results show that gelam from both ecosystems exhibits morphological differences and variations in some tissues (in leaf, petiole, bark, and root anatomy such as in type of epicuticular waxes, bark anatomy, leaf anatomy, vascular bundle, bark fibre pits, vessel, phloem, xylem, cortex, epidermal cells and mesophyll cells). This initial observation may suggest that gelam can adapt well in different micro-ecosystems of Terengganu. Its ability to response well toward Terengganu's different climates and coastal environmental changes could make gelam a viable tree for conservation and landscape program.
Frick, A; Möller, H; Wirbitzki, E
From the marketed drug product Roxane(R) 75 mg C/MR capsules (roxatidine controlled/modified-release capsules), an in vitro/in vivo comparison was performed to demonstrate a 1:1 correlation between in vitro and in vivo dissolution, and, furthermore, to ensure bioequivalence of the roxatidine controlled/modified-release (C/MR) capsules exhibiting dissolution profiles within the defined acceptance criteria. This 1:1 in vitro/in vivo comparison was calculated using a model independent numerical deconvolution method. The high degree of correlation is extremely rare, nevertheless it allows to omit the testing of clinical side batches for the setting of acceptance criteria for the in vitro dissolution of roxatidine controlled/modified-release (C/MR) capsules. The 1:1 in vitro/in vivo correlation can be explained by the biopharmaceutical characteristics of the drug substance as well as the drug product, that is, pH-independent high solubility of the drug substance as well as dissolution which is independent of pH and agitation. These facts lead to a controlled/modified-release formulation. Therefore, it is important to keep in mind that in most cases in which a pH-dependent solubility/dissolution as well as permeability characteristics can be found, a 1:1 in vitro/in vivo correlation could not be expected.
Xiang, Y; Reuterskiöld-Hedlund, C; Yu, X; Yang, C; Zabel, T; Hammar, M; Akram, M N
We report on the design, fabrication and analysis of vertical-cavity surface-emitting transistor-lasers (T-VCSELs) based on the homogeneous integration of an InGaAs/GaAs VCSEL and an AlGaAs/GaAs pnp-heterojunction bipolar transistor (HBT). Epitaxial regrowth confinement, modulation doping, intracavity contacting and non-conducting mirrors are used to ensure a low-loss structure, and a variety of design variations are investigated for a proper internal biasing and current injection to ensure a wide operating range. Optimized devices show mW-range output power, mA-range base threshold current and high-temperature operation to at least 60°C with the transistor in its active mode of operation for base currents well beyond threshold. Current confinement schemes based on pnp-blocking layers or a buried tunnel junction are investigated as well as asymmetric current injection for reduced extrinsic resistances.
Watt, Robert Gregory [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)
The Eulerian AMR rad-hydro-MHD code Roxane was used to investigate modifications to existing designs of the new RancheroS class of Magnetic Flux Compression Generators (FCGs) which might allow some members of this FCG family to exceed 100 MA driving a 10 nH static load. This report details the results of that study and proposes a specific generator modification which seems to satisfy both the peak current and desired risetime for the current pulse into the load. The details of the study and necessary modifications are presented. For details of the LA43S RancheroS FCG design and predictions for the first use of the generator refer to the relevant publications.
Full Text Available In comparison to the oceans, freshwater environments represent a more diverse community of microorganisms, exhibiting comparatively high levels of variability both temporally and spatially Maranger and Bird, Microb. Ecol. 31 (1996 141–151. This level of variability is likely to extend to the world of viruses as well, in particular bacteria-infecting viruses (bacteriophages. Phages are known to influence bacterial diversity, and therefore key processes, in environmental niches across the globe Clokie et al., Bacteriophage 1 (2011 31–45; Jacquet et al., Adv. Ocean Limn. 1 (2010 97–141; Wilhelm and Suttle, Bioscience 49 (1999 781–788; Bratback et al., Microb. Ecol. 28 (1994 209–221. Despite their prevalence and likely critical role in freshwater environments, very few viral species have been characterized. Metagenomic approaches, however, have allowed for a glimpse into phage diversity. We collected surface water samples from four Chicago area beaches – Gillson Park, Montrose Beach, 57th Street Beach, and Calumet Beach – every two weeks from May 13 through August 5, 2014. Sampling was conducted with four biological replicates for each sampling date and location, resulting in 112 samples. DNA isolated from each of the individual samples for a given collection date/location was pooled together, with one exception – Calumet Beach on August 5, 2014 – in which each biological replicate was sequenced individually. Raw sequence data is available via NCBI’s SRA database (part of BioProject PRJNA248239.
Full Text Available Bigsby, Christopher. Remembering and Imagining the Holocaust: The Chain of Memory by Roxane Riegler Bruce, Iris. Kafka and Cultural Zionism. Dates in Palestine by Bettina Matthias Haase, Christine. When Heimat Meets Hollywood: German Filmmakers and America, 1985-2005 by Maria Stehle Herzog, Dagmar. Sex after Fascism: Memory and Morality in Twentieth-Century Germany by Sabine Hake Iossel, Mikhail and Jeff Parker. Amerika. Russian Writers View the United States by Yuliya Minkova Macksey, Richard and Eugenio Donato, eds. The Structuralist Controversy: The Languages of Criticism and the Sciences of Man by Safoi Babana-Hampton Magnarelli, Sharon. Home is Where the (Heart Is: The Family Romance in Late Twentieth-Century Mexican and Argentine Theater by Margo Milleret Matthias, Bettina. The Hotel as Setting in Early Twentieth-Century German and Austrian Literature: Checking in to Tell a Story by Susanne Kelley McGlothlin, Erin. Second-Generation Holocaust Literature: Legacies of Survival and Perpetration by Jennifer Cameron Taberner, Stuart, ed. Contemporary German Fiction: Writing in the Berlin Republic by Alexandra Merley Hill Walter Frisch. German Modernism: Music and the Arts by Jill Suzanne Smith
Kang, Hongtao; Liu, Dafei; Tian, Jin; Hu, Xiaoliang; Zhang, Xiaozhan; Yin, Hang; Wu, Hongxia; Liu, Chunguo; Guo, Dongchun; Li, Zhijie; Jiang, Qian; Liu, Jiasen; Qu, Liandong
Feline panleucopenia virus (FPV) is a highly infectious pathogen that causes severe diseases in pets, economically important animals and wildlife in China. Although FPV was identified several years ago, little is known about how it overcomes the host innate immunity. In the present study, we demonstrated that infection with the FPV strain Philips-Roxane failed to activate the interferon β (IFN-β) pathway but could antagonize the induction of IFN stimulated by Sendai virus (SeV) in F81 cells. Subsequently, by screening FPV nonstructural and structural proteins, we found that only nonstructural protein 2 (NS2) significantly suppressed IFN expression. We demonstrated that the inhibition of SeV-induced IFN-β production by FPV NS2 depended on the obstruction of the IFN regulatory factor 3 (IRF3) signaling pathway. Further, we verified that NS2 was able to target the serine/threonine-protein kinase TBK1 and prevent it from being recruited by stimulator of interferon genes (STING) protein, which disrupted the phosphorylation of the downstream protein IRF3. Finally, we identified that the C-terminus plus the coiled coil domain are the key domains of NS2 that are required for inhibiting the IFN pathway. Our study has yielded strong evidence for the FPV mechanisms that counteract the host innate immunity. PMID:28125002
Peacock, Gina F; Sauvageot, Jurgita; Hill, Ashley; Killian, Alyssa
Mercaptopurine is commonly used to treat acute lymphoblastic leukemia and has historically been commercially available only in tablet form. Since tablets may be difficult for children and elderly patients to swallow, many pharmacists have compounded mercaptopurine suspensions. The U.S. Food and Drug Administration recently approved a commercial suspension, but it is not widely available at this time. Therefore, pharmacists may still need to compound mercaptopurine suspension for use in areas where it is not available or if the commercial suspension is in short supply. Stability studies must be conducted in order to assign appropriate beyond-use dates for compounded preparations. The objective of this study was to evaluate the stability of extemporaneously compounded suspensions using commercially available mercaptopurine tablets, as well as active pharmaceutical ingredient in a vehicle of Ora-Sweet and Ora-Plus (1:1) stored in plastic and glass containers at room temperature. Each mercaptopurine preparation was analyzed using a validated stability-indicating high-performance liquid chromatography method at the following time points: 0, 7, 14, 21, 30, 60, and 90 days. Suspensions were also observed for changes in appearance or odor, and pH was tested at each time point. The suspension compounded from Roxane generic tablets was extremely viscous and was therefore eliminated from the study. All other suspensions showed no observed physical changes and maintained greater than 93% of initial concentration of mercaptopurine for the entire study period.
Full Text Available Feline panleucopenia virus (FPV is a highly infectious pathogen that causes severe diseases in pets, economically important animals and wildlife in China. Although FPV was identified several years ago, little is known about how it overcomes the host innate immunity. In the present study, we demonstrated that infection with the FPV strain Philips-Roxane failed to activate the interferon β (IFN-β pathway but could antagonize the induction of IFN stimulated by Sendai virus (SeV in F81 cells. Subsequently, by screening FPV nonstructural and structural proteins, we found that only nonstructural protein 2 (NS2 significantly suppressed IFN expression. We demonstrated that the inhibition of SeV-induced IFN-β production by FPV NS2 depended on the obstruction of the IFN regulatory factor 3 (IRF3 signaling pathway. Further, we verified that NS2 was able to target the serine/threonine-protein kinase TBK1 and prevent it from being recruited by stimulator of interferon genes (STING protein, which disrupted the phosphorylation of the downstream protein IRF3. Finally, we identified that the C-terminus plus the coiled coil domain are the key domains of NS2 that are required for inhibiting the IFN pathway. Our study has yielded strong evidence for the FPV mechanisms that counteract the host innate immunity.
Polishook, D.; Brosch, N.; Prialnik, D.
Durda et al. (Durda, D.D., Bottke, W.F., Enke, B.L., Merline, W.J., Asphaug, E., Richardson, D.C., Leinhardt, Z.M. . Icarus 170, 243-257), using numerical models, suggested that binary asteroids with large separation, called Escaping Ejecta Binaries (EEBs), can be created by fragments ejected from a disruptive impact event. It is thought that six binary asteroids recently discovered might be EEBs because of the high separation between their components (∼100 > a/Rp > ∼20). However, the rotation periods of four out of the six objects measured by our group and others and presented here show that these suspected EEBs have fast rotation rates of 2.5-4 h. Because of the small size of the components of these binary asteroids, linked with this fast spinning, we conclude that the rotational-fission mechanism, which is a result of the thermal YORP effect, is the most likely formation scenario. Moreover, scaling the YORP effect for these objects shows that its timescale is shorter than the estimated ages of the three relevant Hirayama families hosting these binary asteroids. Therefore, only the largest (D ∼ 19 km) suspected asteroid, (317) Roxane, could be, in fact, the only known EEB. In addition, our results confirm the triple nature of (3749) Balam by measuring mutual events on its lightcurve that match the orbital period of a nearby satellite in addition to its distant companion. Measurements of (1509) Esclangona at different apparitions show a unique shape of the lightcurve that might be explained by color variations.
Full Text Available Tropical peatlands are one of the most important terrestrial ecosystems in terms of impact on the atmospheric greenhouse gas composition. Currently, greenhouse gas emissions from tropical peatlands following disturbances due to deforestation, drainage or wildfire are substantial. We quantified in situ nitrous oxide (N2O fluxes during both dry and wet seasons using a closed chamber method at sites that represented differing land uses and land use change intensities in Central Kalimantan, Indonesia. Cumulative N2O fluxes were compared with carbon dioxide (CO2 and methane (CH4 fluxes.
The mean N2O flux rates (N2O-N ±: SD, mg m−2 h−1 varied as follows: drained forest (0.112 ± 0.293 > agricultural peat at the Kalampangan site (0.012 ± 0.026 > drained burned peat (0.011 ± 0.018 > agricultural peat at the Marang site (0.0072 ± 0.028 > undrained forest (0.0025 ± 0.053 > clear-felled, drained, recovering forest (0.0022 ± 0.021. The widest N2O flux range was detected in the drained forest (max. 2.312 and min. −0.043 mg N2O-N m−2 h−1. At the other flux monitoring sites the flux ranges remained at about one tenth that of the drained forest site. The highest N2O emission rates were observed at water tables close to the peat surface where also the flux range was widest. Annual cumulative peat surface N2O emissions (expressed in CO2 equivalents as a percentage of the total greenhouse gas (N2O, CO2 and CH4 emissions were 9.2 % at highest, but typically ~1 %. Average N2O fluxes and also the total of monitored GHG emissions were highest in drainage-affected forest which is characterized by continuous labile nitrogen availability from vegetation, and water tables typically below the surface.
Stachel, T.; Chacko, T.; Luth, R. W.
Because of the inability of depleted cratonic peridotites to effectively buffer oxygen fugacities when infiltrated by CHO or carbonatitic fluids, it has been proposed recently (Luth and Stachel, 2014) that diamond formation in peridotites typically does not occur by rock-buffered redox reactions as previously thought but by an oxygen-conserving reaction in which minor coexisting CH4 and CO2 components in a water-rich fluid react to form diamond (CO2 + CH4 = 2C + 2H2O). In such fluid-buffered systems, carbon isotope fractionation during diamond precipitation occurs in the presence of two dominant fluid carbon species. Carbon isotope modelling of diamond precipitation from mixed CH4- and CO2-bearing fluids reveals unexpected fundamental differences relative to diamond crystallization from a single carbon fluid species: (1) irrespective of which carbon fluid species (CH4 or CO2) is dominant in the initial fluid, diamond formation is invariably associated with progressive minor (water-rich fluids responsible for diamond formation. Specifically, precipitation of diamonds with δ13C values in the range -4 to -6‰ from mantle-derived fluids with an average δ13C value of -5‰ (derived from evidence not related to diamonds) requires that diamond-forming fluids were relatively reduced and had methane as the dominant carbon species (XCO2 = 0.1-0.5). Application of our model to a recently published set of in-situ carbon isotope analyses for peridotitic diamonds from Marange, Zimbabwe (Smit et al., 2016), which contain CH4 fluid inclusions, allows us to perfectly match the observed co-variations in δ13 C, δ15 N and N content and at the same time explain the previously counter-intuitive observation of progressive 13C enrichment in diamonds that appear to have grown from a fluid with methane as the dominant carbon species. Similarly, the almost complete absence in the published record of progressive 13C depletion trends within diamonds likely reflects ubiquitous
@@ 动物衣原体病(Chlamydiosis)是由各类衣原体(Chlamydia)感染哺乳动物、禽类、节肢昆虫所发生的一类十分重要的自然疫源性传染病.该病属人畜共患,呈地方流行,常造成很大危害及经济损失.目前已发现18个目、29个科的190余种鸟类(包括70余种观赏鸟和家禽)以及绵羊、山羊、牦牛、马属动物、猪、犬、猫、猴、兔、豚鼠及小鼠等许多哺乳动物、野生动物受到过感染.衣原体可分为沙眼衣原体(Chlamydia trachomatis)和鹦鹉热衣原体(Chlamydia psittaci).近年来的研究发现,原列入鹦鹉热衣原体的独特的TWAR株(台湾株),在原体形态结构、核酸组成、天然宿主及致病性等方面与鹦鹉热衣原体有所不同,因此,将其从鹦鹉热衣原体中独立出来,定名为肺炎衣原体(Chlamydia pneumoniae).动物衣原体病的研究始于19世纪末,Marange(1892)在阿根廷首都布宜诺斯艾利斯发现,与鹦鹉鸟接触的人会突然发病,从而最终肯定了鹦鹉鸟在人类感染和罹病中的重要作用,并提出了鹦鹉热(Psittacosis)这一新病名.